Powassan and Silverwater viruses: ecology of two Ontario arboviruses. Powassan virus was isolated from a pool of Ixodes marxi ticks collected during late August 1962, from a red squirrel, Tamiasciurus hudsonicus, and from blood obtained from a red squirrel during early October 1962 near Powassan, Ontario, where a child contracted fatal encephalitis due to this virus in September 1958. The frequent detection of Powassan virus neutralizing antibody in sera of squirrels captured during autumn, but rarely at other seasons, and the frequent I. marxi infestation of squirrels, some of which contain antibody, but the lack of occurrence of I. marxi on other forest rodents, suggest that I. marxi ticks are vectors and squirrels are reservoirs of Powassan virus infection. Isolation of Silverwater virus from Haemaphysalis leporis-palustris ticks which infested a snowshoe hare Lepus americanus near Powassan demonstrates the presence of this agent in the Powassan area also.


Leucosarcoma of the bone marrow.

Leucosarcoma of the bone marrow.


Measurement of cutaneous moisture vaporization from cattle by ventilated capsules.


The partition of insensible losses of body weight and heat from cattle under various climatic conditions.


Direct blood-transfusion in severe haemorrhage after heart surgery.


Effect of adrenalectomy and of growth hormone on enzymes concerned with urea synthesis in rat liver.


Synergistic renal effects of DCI and cortisone in mice poisoned with bacterial endotoxin.


The role of adrenocorticortirophic and adrenocortico-steroid hormones in the treatment of tuberculosis.


Clinical intution: a tutorial discussion.


Boredom.

Boredom.


The acid phosphatase of yeast. Localization and secretion by protoplasts.


The immune response to tissue transplants.


Phocomelia. A case report without thalidomide ingestion.


Oculomycosis.

Oculomycosis.


The social class position of one visiting nurse association.


Three sequential experiments in radiation treatment of cervical cancer.


Vaginal smears. A plea for more critical evaluation. To determine whether a conscious effort to reduce the incidence of equivocal (Class III) vaginal cytologic smear readings might have demonstrable clinical value, we have compared a previous study of our predictive efforts with a recent experience in screening a similar number of patients. It was possible to achieve an appreciable reduction in the incidence of Class III smears-from 2.4 per cent to 0.6 per cent. There was a modest increase in the reliability of the Class III smear as an indicator of cancer and a very notable increase in the reliability of the Class IV and V interpretations. While only 66 per cent of the earlier group with Class IV and V smears were shown to have cancer, 86 per cent of the present series with IV and V readings had malignant disease (97 per cent of the Class V group). The ultimate yield of malignancies was similar in the two series, but theoretically the overloading of Classes III, IV and V with women who do not actually have cancer necessarily leads to large numbers of diagnostic surgical procedures that might be avoided. Class III should be used to denote merely a temporary state of inconclusiveness rather than a real suspicion of cancer. With proper collaboration between physician and cytologist, most of the initially confusing situations can be either upgraded or downgraded to the proper rating, and eventually the bulk of patients standing to profit from conization will fall into Classes IV or V.


Triple fixation suture in operative gynecology. A secure three-point fixation suture for large tissue pedicles is described. It is particularly applicable to vaginal hysterectomy but is also useful during abdominal hysterectomy.


The release of epinephrine from rabbit adrenal medulla chromaffin granules.


Thermostable staphylococcal toxin.

Thermostable staphylococcal toxin.


Synthesis of plasma antihaemophilic factor.


Post-mortem changes in the colour of pig longissimus dorsi muscle.


Pericarditis.

Pericarditis.


Demineralization of whey. Use of its protein in infant feeding.


The competitive inhibition of the N-demethylation of butynamine 9y 2,4-dichloro-6-phenylphenoxy-ethylamine (DPEA).


Congenital nonhemolytic jaundice (Crigler-Najjar syndrome): report of a case.


Foreign body in the lung.

Foreign body in the lung.


Bottled sterile water for operating-theatres.


Daily visits to the launching pads.

Daily visits to the launching pads.


"Neuron" or "neurone"?

"Neuron" or "neurone"?


Pathological aspects.

Pathological aspects.


Dangerous marine molluscs.

Dangerous marine molluscs.


Measuring purchasing performance.

Measuring purchasing performance.


The heart and digitalis.

The heart and digitalis.


Some effects of the catecholamines on spinal cord reflexes.


Hemorrhage in the newborn.

Hemorrhage in the newborn.


The effect of various solvents and other conditions on periodate oxidation of carbohydrates in the PAS reaction.


An apparatus for programming and recording differentiated timing responses.


The developmental history of the plasmacyte.


Neurilemmoma. Report of three cases.

Neurilemmoma. Report of three cases.


Elaidinized olive oil and cholesterol atherosclerosis.


Retinoblastoma.

Retinoblastoma.


Pseudomonas pyocyanea infection treated with colistin methane sulphonate.


The metabolism of brain pyruvate and acetate in the tricarboxylic acid cycle.


Specific precipitin bands in the serology of histoplasmosis.


The problem of the ageing population.

The problem of the ageing population.


Particulate ribonucleoprotein components of Hevea brasiliensis latex.


Detection of the small left-to-right intracardiac shunt with methyl iodide I-131.


The surgical treatment of cerebral arterial insufficiency.


Therapist "type" and patient response to psychotherapy.


Patient and therapist influences on quitting psychotherapy.


Induction of resistance to sarcoma 180 tumor in mice. Differential effects of rabbit and guinea pig sera.


Antitumor action of several new piperazine derivatives compared to certain standard anticancer agents.


Emergency room treatment of myasthenia gravis.


Angiosarcoma of the heart. Report of a case and review of the literature.


Joseph WOLPE: his theories and method of dirctive psychotherapy.


A modified technique of intravenous anaesthesia with meperidine and succinylcholine.


Blood volume measurements in patients receiving cardiovascular surgical treatment.


The ideal director of an otolaryngological department in a teaching hospital.


Prevention of infant deaths from congenital heart disease.


Influence of experience upon form constancy.


Patterns of adenovirus infection in the respiratory diseases of naval recruits. A longitudinal study of two companies of naval recruits.


Energy requirements for nitrogen fixation by cell-free preparations from Clostridium pasteurianum.


Histochemical investigation of the tubular glands of the pars nervosa of the human hypophysis.


Diagnosis of headache.

Diagnosis of headache.


Political aspects of fluoridation.

Political aspects of fluoridation.


The Far East and Canada.

The Far East and Canada.


Health on a "hot line".

Health on a "hot line".


Maturation rate and body build in women.


Stinging coral and so-called stinging seaweed.


Comparison of the bacteria found in the ear and nasopharynx in acute otitis media.


Lingual thyroid.

Lingual thyroid.


Good training leads to good food service.


Richard J. BLOCK as scientist and individual: May 4, 1906-February 4, 1962.


A preliminary investigation into automatic blood grouping.


Cardiac arrest following EST (successful management of a case).


Patterns of aggression.

Patterns of aggression.


Adventure in community psychiatry (theoretical and management a spects).


Whipworms in rural worms.

Whipworms in rural worms.


Exchange transfusion in severe toxaemia.


Thrombolytic therapy.

Thrombolytic therapy.


Experience with streptokinase infusions.


Treatment of peripheral arterial occlusion by streptokinase perfusion.


In-vitro and in-vivo studies of a preparation of urokinase.


Nikethamide for severe CO2 retention in exacerbations of chronic bronchitis.


The ABC's of static in the operating room.


Malignant pleural mesothelioma in an asbestos worker.


Inherited vascular pattern of the femoral head and neck as a predisposing factor to Legg-Calve-Perthes disease.


A mutation in the mouse with variable expression causing chorea and tail abnormalities.


The metabolism of isoxanthopterin by Alcaligenes faecalis.


Effect of intraductal or intravascular norepinephrine infusion on the development of acute hemorrhagic pancreatitis.


Podiatry and rehabilitation.

Podiatry and rehabilitation.


Bloch-Sulzbeger syndrome (incontinentia pigmenti). Report of a case with prominent neurological features.


Photocoagulation.

Photocoagulation.


Congenital anorectal anomalies.

Congenital anorectal anomalies.


Preparation of the patient for colon surgery.


Experiment at City Point.

Experiment at City Point.


More aspirin poisoning.

More aspirin poisoning.


Epidermoid carcinoma of cervix, vagina, and vulva: a regional disease.


An acute malabsorption syndrome with reversible mucosal atrophy.


The surgical treatment of orbital tumors.


The effect of digitalization in irreversible hemorrhagic shock.


Science and serendipity: the fluoride saga.


Inservice nursing education. One hospital developed a continuing program.


Coping with feelings of helplesness.

Coping with feelings of helplesness.


Morphogenesis and nutrition in the Memnionella-Stachybotrys group of fungi.


Benign catarrhal lymph-adenitis.

Benign catarrhal lymph-adenitis.


The problem of the noninbred animal in tissue transplantation.


Pyelonephritis.

Pyelonephritis.


Experimental influenza in sheep.

Experimental influenza in sheep.


Chlorpromazine-induced weakness in myasthenia gravis.


Asthenic syndrome. Anticholinesterase tolerance in nonmyasthenic patients.


The etiology and management of the cerebral capillary pathological reactions.


An experience with electric heat.

An experience with electric heat.


Clinical comparison of halothane (Fluothane) and chloroform.


Reactions to novel and familiar stimuli as a function of schizophrenic withdrawal.


Presentation of the Manson Medal, 1962 (E. SERGENT).


Sigmoidovesical fistulae complicating diverticulitis.


Tumors of the breast. Ratio of benign to malignant tumors; decrease in percentage of axillary metastases.


Abortion anticipated by simplified smears.


Disseminated bone tuberculosis. Review of the literature and presentation of an unusual case.


Surgery in the rural midwest. The need, the problem, and the opportunity.


Medical authors and professional writers. Medical writing is a legitimate field for specialization. The specialist literary consultant should be part of the research team. He could smooth the way for both researcher and reader, and could increase the researcher's productivity and his audience.


Developmental biology of Myxococcus.

Developmental biology of Myxococcus. McVittie, Anne (Cornell University, Ithaca, N.Y.), Frances Messik, and Stanley A. Zahler. Developmental biology of Myxococcus. J. Bacteriol. 84:546-551. 1962.-Methods for the growth and enumeration of strain FB of Myxococcus xanthus were investigated. Several mutants unable to form fruiting bodies were isolated. These fell into at least two classes. Members of each class acted synergistically with members of other classes to form fruiting bodies; intraclass synergism did not occur. Mechanisms for the loss of ability to form fruiting bodies, and for synergistic interaction, were studied.


Sulphites and carbonylamino chromophore development.


A thousand outpatients.

A thousand outpatients.


Adequate cytology examination.

Adequate cytology examination.


Resistance of salmonellae isolated in 1962 to chloretetracycline. Among 652 salmonellae examined, Salmonella typhimurium displayed a much higher incidence of resistance to chlortetracycline than did other serotypes. Among S. typhimurium cultures from man, the incidence of resistance (38%) increased markedly over that of cultures isolated 3 years previously (13.9%), whereas a similar increase was not noted among cultures from fowls. Resistance among cultures from animals other than fowls (72.5%) was due largely to the high incidence of resistance among cultures from bovine sources (93.7%).


Cytology and biopsy in carcinoma of the uterine cervix.


Speech clinic joins child guidance center: a study in interdisciplinary collaboration.


Thrombophlebitis following the use of norethynodren (Enovid).


Rupture of the biceps brachii at the lower musculo tendinous junction.


Fracture of the fibular aspect of the lower tibial epiphysis.


Traumatic paraplegia.

Traumatic paraplegia.


The prevalence of pulmonary tuberculosis in a rural population in Jamaica.


Gastrolith growth and calcium shifts in the freshwater crayfish, Orconectes virilis.


Comparative studies on some ammonia-producing enzymes in the excretory organs of vertebrates.


An immunologic unitarian concept of cancer.


Analysis of some sex ratio data.

Analysis of some sex ratio data.


Staphylococcus aureus in a maternity hospital. III. Sources and patterns of staphylococcal infections.


HFR males in Salmonella abony.

HFR males in Salmonella abony.


Patterns of sexual recombination in enteric bacteria.


Cerebral arteriovenous aneurysms. A review of 50 cases.


Fluid space measurements in burned children.


Diagnosis and treatment of acute ruptures of the various components of the lateral ligaments of the ankle.


Lacerations of the lateral ligament of the ankle. An experimental appraisal.


Pathophysiology of plasmin system I. Routine measuring method of plasmin system in this clinic.


Pathophysiology of plasmin system. II. Fibrinolysis and plasmin (activator)--inhibitor ratio.


Pathophysiology of plasmin system. III. A contribution to the mechanism of incoagulability of menstrual and intraperitoneal blood.


Pathophysiology of plasmin system. IV. Correlation of plasma protein bound polysaccharides and plasmin system.


Recurrence due to intraluminally exfoliated gastric cancer cells.


Cancer cell dissemination during surgical manipulation.


Effect of the preoperative irradiation and subcutaneously cancer tissue implantation of the antitumor antibody levels. I.


Study about radiological and immunological treatment for cancer. (How did we establish our plan of the cancer therapy).


The role of androgens in inducing experimental electrolyte-steroid-cardiopathy.


Some notes on the coenzyme-activity of phosphopyridoxal derivatives for the brain glutamic decarboxylase.


The cytological effect of chemicals on tumors. XV. Inhibitory effects of podophyllin (or podophyllotoxin) and triethylene melamine, alone and in combination, on ascites tumors of rats.


A long Y chromosome in man.

A long Y chromosome in man.


A further survey of the chromosomes in the Japanese.


Studies on alkylated furan derivatives. I. Syntheses and antimicrobial activity of N-heterocyclyl-5-nitro-2-furamide. I.


The application of the ballistocardiograph to the study of cardio-vascular arteriosclerosis.


Quantitative analysis of fecal bile acids by gas-liquid chromatography.


Retinoblastoma in a 52-year-old man.

Retinoblastoma in a 52-year-old man.


Patient and physician delay in cancer diagnosis: medical aspects.


The results of irradiation therapy of carcinoma of the cervix.


Zollinger-Ellison syndrome. Report of a case.


Secondary localized cutaneous amyloidosis.


Bound ascorbic acid in liver.

Bound ascorbic acid in liver.


Increase of ascorbic acid in cauliflower during blancing.


The iron uptake by reticulocytes in normal subjects, in subjects with thalassaemia minor and in patients with thalassaemia major. In vitro studies.


The role of potassium ion in the genesis of hypertension.


Fat metabolism in patients with myocardial infarction. Study with I-131 raolein.


Effect of ionizing radiation on lipid metabolism in blood cells in vitro.


C.H. Hardin BRANCH, M.D., eighty-ninth president 1962-1963. A biographical sketch.


Physio- and anatomo-pathology of acute ischemia of the extremities.


Occupational health in Eastern Europe.

Occupational health in Eastern Europe.


Toxicity of Evans blue dye in the monkey and tracing of it in the tooth pulp.


Studies on metabolism of vitamin A. 1. The biological activity of vitamin A acid in rats.


Colorimetric phosphate analysis in fluoride-containing solutions.


Operative and post-operative eye complications in retina detachment.


Association of radioactive chromium with various components of hemoglobin.


The surgical management of massive epistaxis.


Electron microscopy of the lupus erythematosus cell.


Characteristics of the daily rhythm of menstruation and labor.


Continuous cultivation of microorganisms. A review.


Daily rhythm of leukocytes, blood pressure, pulse rate, and temperature during pregnancy.


Episodic abducens paralysis during transient decerebrate rigidity associated with a colloid cyst of the third ventricle. A case report.


The proposed use of tetacycline antibiotics for the evaluation of the degree of burns.


New aspects of tetracycline analogues distribution and fixing in pathologically changed tissue.


Distribution and retention of tetracycline analogues in kidney tissue in some pathological conditions.


Fluorescence of tetracycline analogues fixed in myocardial infarction.


Comparison of amino acid activation in cell-free extract of aerobically and anaerobically cultered yeast cells.


On the nature of a sparing effect by thymidine on the utilization of deoxycytidine.


Nucleotide interconversions. VIII. Thymidine-sparing effect on the utilization of de-cytidine by chick-embryo mince.


Nucleotide interconversions. X. Deoxyribo- and ribonucleoside 5'-phosphate synthesis via a phosphotransferase reaction in chick embryo extracts.


Nucleotide interconversions. IX. The regulatory influence of deoxycytidine 5'-triphosphate and deoxythymidine 5'-triphosphate on deoxycytidylate deaminase.


Use of a neuroleptic-antidepressant combination in office practice.


Attitudes and safety in recreation.

Attitudes and safety in recreation.


The impaired driver.

The impaired driver.


Intraarterial chemotherapy and x-ray therapy in cancer of the head and neck. Technique, methods, results and complications.


The cytopathic effects of vervet monkey viruses.


Sindbis virus infection in man. Report of a case with recovery of virus from skin lesions.


Some observations on anaplasmosis.

Some observations on anaplasmosis.


Investigations on the mechanism of potentiation of barbiturate hypnosis by hersaponin, acorus oil, reserpine and chlorpromazine.


Yoga and mental hygiene.

Yoga and mental hygiene.


Effects of rat strain, stilbestrol and testosterone on the occurrence of hemorrhagic diathesis in rats fed a ration containing irradiated beef.


Effect of methionine and age of rat on the occurrence of hemorrhagic diathesis in rats fed a ration containing irradiated beef.


Family planning knowledge and practices among women attending some New Delhi M.C.W. centers. (A pilot study).


Treatment of severe hypertension with guanethidine.


Inturnings of the outer limiting mitochondrial membrane.


Fixation for electron microscopy.

Fixation for electron microscopy.


'Accidentally-discovered' carcinoma of the cervix.


Effect of carbon tetrachloride on hepatic synthesis and release of triglycerides.


Electron spin resonance in ATP and RNA.

Electron spin resonance in ATP and RNA. Cu(++), Mn(++), and Fe(+++) account for the electron spin resonances observed in certain samples of ATP and RNA. The copper ion seems more loosely bound to these substances than either iron or manganese. A striking similarity is observed between the manganese spectra in manganese RNA, ATP, and ADP suggesting that the binding sites are similar in the three compounds. The similarity of the e.s.r. spectra of iron ATP and of iron and manganese RNA, except for hyperfine spectrum (hfs) in the latter, suggests that the two ions bind similarly in the two compounds. A detailed interpretation of the spectra is lacking however and these conclusions can only be tentative. When manganese TPP and ATP are heated or pH changed the e.s.r. alters indicating a change in the environment of the ion. The sharp 6 line manganese spectrum in both TPP and ATP at pH 1 suggests an almost "free" ion at this pH in the sense of an almost isotropic average environment.


Contribution to the anatomy of the vegetative nervous system in the neck and thorax of the domestic pigeon.


The nerve supply of the stomach in the domestic pigeon (Columba domestica).


Vascular and extravascular radioactivity after the injection of estradiol 6, 7H in the human being.


Effect of stilbene derivatives on cholesterol-fed chickens.


The significance of metabolic competitors in the treatment of virus diseases.


Primary leiomyosarcoma of the vagina. Report of 8 cases.


Primary ovarian pregnancy: report of two cases.


Correlation between clinical and electroencephalographic findings during the first stage of nitrous oxide anesthesia.


Cysteamine protection of x-ray-induced dysplasia in mouse hair.


The ultrastructure of isolated and in situ human cardiac age pigment.


Some contributions to the psychoendocrinology of premenopausal oestrogen deficiency.


The performance of a gamma camera for the visualization of radioactive isotope in vivo.


Clinical applications of a gamma camera.


Serological reactions of mouse plasma fractions.


Investigation of cerebral blood-flow in hypertension, using radioactive-xenon inhalation and extracranial recording.


A special consideration of temporomandibular joint disturbances, with particular emphasis on myositis and x-ray determination of changes in the head of the condyle.


Validity of the concept of energy of maintenance.


Phencyclidine analgesia in multiple rib fractures.


The technical aspects of the vascular stapler.


A study of infectious bronchitis virus before and after resin treatment for separation from a cell-attachment-and-growth factor.


Cocci test for detecting mouth and nose pollution of swimming pool water.


Safeness and servability of meringued pie.


Cold effects in rat: plasma and adipose tissue free fatty acids and adipose lipase.


Observations on coarctation of the aorta in infants.


Left atrial myxoma associated with an atrial septal defect.


The use of ACD blood titrated with THAM in extracorporeal circulation.


Airways obstruction and uneven gas distribution in the lung.


A clinical and pathological study of interatrial myxomas.


Evidence of adrenergic neurons with synaptic terminals in the retina of rats demonstrated with fluorescence and electron microscopy.


Failure of inoculation with polyoma virus to influence chemical carcinogenesis in mice.


The personality of 5- to 7-year-old enuretics in the light of the Sceno and Rorschach tests.


On central and autonomic nervous system mechanisms in conditioning, learning, and performance.


Chid psychiatry in Minnesota.

Chid psychiatry in Minnesota.


The development of psychiatry at the University of Minnesota Medical School.


Serologic and immunologic studies with African swine fever virus.


Serum ornithine carbamoyl transferase and transaminase activity in rheumatic disease.


Neurosurgical possibilities in the treatment of spasticity. A survey.


Specific enzymatic determination of glucose in blood serum or plasma by an automatic potentiometric reaction-rate method.


Metal-ion activation, metal binding, and sulfhydryl groups in native and denatured enolase from rabbit muscle.


Scale-symmetry and the semantic differential.


The vacuum extractor.

The vacuum extractor.


Ethnocentrism and the acceptance of Negro support in a group pressure situation.


Some observations on children of disorganized families and problems of acting our.


Magnetic isotropy of the red blood cell.


A histochemical study of the formation of deutoplasmic components in developing oocytes of the zebrafish, Brachydanio rerio.


Antagonism and toxicity of IDU by its degradation products.


Treatment of blunt trauma to the thorax.


Analysis of chemical constituents of blood by digital computer.


Myelocyte-metamyelocyte transition in the bone marrow of the dog.


Intermediary metabolism of thyroid tissue and the action of drugs.


Office treatment of common nasal conditions.


A digest of essential proctologic procedures.


The effects of beta-mercaptoethanol on the morphogenetic movements of amphibian embryos.


Knife wound of the neck, with transection of the esophagus and contralateral hemopneumothorax.


[3'-phenyl-propyl-(2')]-1, 1-diphenyl-propyl-(3)-amine (Segontin).


Ontogenetic change in the meaning of concepts as measured by the semantic differential.


Fluency and originality in written themes.


Motivation and the direction of thinking.


Hydatidiform mole complicated by apoplexie uteroplacentaire (Couvelaire).


The frequency of mental disease: a study of trends in New York state.


Mental disease among Polish-born and native whites of Polish-born parentage in New York State, 1949-1951.


Mental disease among Irish-born and native whites of Irish parentage in New York State, 1949-1951.


Mental disease among Italian-born and native whites of Italian parentage in New York State, 1949-1951.


The distribution of mental disease according to religious affiliation in New York State, 1949-1951.


Mental disease among Swedish-born and native-born of Swedish parentage in New York State, 1949-1951.


Treatment of pollen-sensitive patients with a slowly absorbed alum precipitated pyridine-pollen suspension in aqueous solution.


Investigations on the nature of hemophilia A.


Activation of bovine prothrombin to autoprothrombrin II.


Clinical experiences with halothane.

Clinical experiences with halothane.


Acute ascending necrotizing myelopathy associated with visceral carcinoma.


Cerebral palsy. A review of 275 cases.

Cerebral palsy. A review of 275 cases.


Effect of nialamide on the electroencephalographically recorded activity of the brain.


Hirschsprung's disease. Clinical analysis of 11 cases.


Morbidity and mortality in children in Northern India. (Punjab). Based on an analysis of 10,990 admissions.


Severe anaemias in children. (An analysis of 105 cases).


Muscular subaortic stenosis.

Muscular subaortic stenosis.


An unusual contact lens complication.

An unusual contact lens complication.


Concerning the mechanism of the increased RNAse activity in lymphatic cells following whole-body irradiation.


An electric analogue for uptake and exchange of inert gases and other agents.


Assessment of condenser-humidifiers with special reference to a multiplegauze model.


Physical methods of gas analysis.

Physical methods of gas analysis.


Glutathione reductase from germinated peas.


Photo-oxidation of ascorbic acid in leaves.


Scope of radioisotope research in biological sciences in the CENTO region countries.


Comparison of the endometrial activity of 3 svnthetic progestins used in fertility control.


Bilateral transfixion injury of the thorax.


The use of rapidly polymerizing adhesives in massive liver resection.


Psychopharmacology. II. Tranquilizers and antipsychotic drugs.


A human case of Trichophyton equinum infection.


Human decidual spiral arterial studies. V. Pathogenetic patterns of intraplacental lesions.


Human decidual spiral arterial studies. VIII. The aetiological relationship between toxaemia-hypertension of pregnancy and spiral arterial placental pathology.


Falling drop method for urine specific gravity.


Arthropod transmission of plant viruses.


Tired woman syndrome.

Tired woman syndrome.


Elliott Proctor JOSLIN, 1869-1962.

Elliott Proctor JOSLIN, 1869-1962.


Ethyl chloride.

Ethyl chloride.


Vitamin A and cholesterol absorption in the chicken.


Hyperglycemia and chlorothiazide.

Hyperglycemia and chlorothiazide.


Appendicitis in a one-year-old child.

Appendicitis in a one-year-old child.


Cyanotic syndrome of portal hypertension in hepatosplenic schistosomiasis and portal cirrhosis. Report of four cases.


Total body perfusion and hypothermia.

Total body perfusion and hypothermia.


Stress responses of pilots flying 6-hour overwater missions in F-100 and F-104 aircraft.


The influence of pseudopregnancy on breast tumour induction in C57BI mice by various chemical carcinogens.


From head nurse to supervisor.

From head nurse to supervisor.


The demonstration of enzymatic activity in pinocytic vesicles of blood capillaries with the electron microscope. In aldehyde-fixed myocardium, enzymatic activity to nucleotide substrates was localized to the pinocytic vesicles of blood capillaries with the electron microscope. No other structures of the endothelial cell showed activity under the conditions employed. These findings are discussed in relation to recent concepts of transport across the capillary wall.


Interpretation of scintigrams obtained after thyroidectomy.


Studies on infectious diseases in wild animals in Utah. III. Experimental Q fever in wild vertebrates.


Studies on infectious diseases in wild animals in Utah. IV. A wild rodent (Peromyscus spp.) plague focus in Utah.


Pasteurella pestis of low virulence for mice and guinea pigs isolated from a Peromyscus plague focus in Utah.


Studies on infectious diseases in wild animals in Utah. II. Susceptibility of wild mammals to experimental plague.


Suprapubic vesicourethral suspension and urinary stress incontinence.


Relationships between vitamin B6 and B12.


Liver acid-soluble nucleotides in orotic acid-fed rats.


Primary septic bursitis.

Primary septic bursitis.


Epithelial papilloma of nose and accessory sinuses.


Our cancer problem.

Our cancer problem.


Irradiation injury to elastic arteries in the course of treatment for neoplastic disease.


Functional alteration in the prothrombin molecule.


Physicians, hospitals, and the Negro patient.


Paper chromatography and chemical structure. IV. Intramolecular hydrogen bonding.


Paper chromatography and chemical structure. VII. The separation of meta- and para-derivatives of benzene.


Paper chromatography and chemical structure. VI. Tautomerism and intramolecular hydrogen bonding in the same molecule. o-Nitrosophenols.


Chondrosarcoma and altered carbohydrate metabolism.


A new apparatus for thin-layer chromatography.


Nucleic acid changes in the germinating peanut.


Preparation and properties of gamma-methyleneglutamic acid.


gamma-Methyl-gamma-hydroxy-alpha-ketoglutaric aldolase. II. Studies with pyruvate-C14.


Method for isolation and determination of alpha-methyl DOPA ethyl ester in aqueous solution.


Platelet phosphatides. Their fatty acid and aldehyde composition and activity in different clotting systems.


Ovarian cortical stromal hyperplasia and carcinoma of the endometrium.


Cytology of the pelvic peritoneal cavity in benign and malignant disease.


Relationship of ovarian hilus cells to benign and malignant endometrium.


Studies on the mechanism of decidualization. II. Histamine-releasing action of pyrathiazine.


A randomized study of the effects of corticosteroid therapy on healing of pulmonary tuberculosis as judged by clinical, roentgenographic, and physiologic measurements.


Malignant lymphoma of the uveal tract.

Malignant lymphoma of the uveal tract.


Dynamics of surface modification in myxovirus-infected cells.


Ototoxic medication in premature children.


The material basis of psychoanalytic conceptualization. Its relation to cybernetics.


Primary adenocarcinoma of the cervix uteri.


The effect of common antacids on intragastric pH. With special reference to dihydroxy aluminium sodium carbonate (Minicid).


Primary irritant patch-test reactions in children.


Eczematous allergy to metals.

Eczematous allergy to metals.


The interrelations of myasthenia gravis and psychic stress: presentation of a case.


Comparison of intradermal test and patch test using nickel sulfate and formaldehyde. A quantitative approach.


Specificity of epicutaneous tests in children. Preliminary report.


Cobalt dermatitis. Clinical picture.

Cobalt dermatitis. Clinical picture.


The practice of otolaryngology.

The practice of otolaryngology.


Clinico-pathologic conference from the School of Veterinary Medicine, University of Pennsylvania.


Treatment of chronic emphysematous bronchitis.


The metabolism of phosphocreatine during an isometric tetanus in the frog sartorius muscle.


Carbonic anhydrase kinetics and inhibition at 37 degrees: an approach to reaction rates in vivo.


The relation between enzyme inhibition and physiological response in the carbonic anhydrase system.


Ionic composition of cerebrospinal fluid and aqueous humor of the dogfish, Squalus acanthias--II. Carbonic anhydrase activity and inhibition.


The binding of inhibitors to carbonic anhydrase in vivo: drugs as markers for enzyme.


Ionic composition of cerebrospinal fluid and aqueous humor of the dogfish, Squalus acanthias--I. Normal values.


Pharmacology: its nature in a medical school.


Results of the survey on professional education of cancer made in different medicine schools of the world.


The use of hyperimmune antivaccinia gamma-globulin for the prevention and treatment of smallpox. Smallpox prophylaxis studies having shown that the classical Jennerian type of vaccination may in some instances prove inadequate to prevent the development of the disease or may be contra-indicated for certain persons, attempts were made to evolve a method which could supplement or replace such vaccination. Investigations reported in this paper have demonstrated that the administration of gamma-globulin obtained from the sera of various animals hyperimmunized with vaccinia virus gives highly effective results in the prevention of different forms of experimental vaccinial infection. Encouraging results were also obtained with this gamma-globulin given prophylactically to 13 persons who had been in close contact with smallpox patients during an outbreak of this disease in Moscow in 1960. The author suggests that hyperimmune antivaccinia gamma-globulin of animal origin may also prove effective in the treatment of postvaccinal complications.


Effect of exogenous oxytocin on the progestogen content of the bovine corpus luteum.


Investigation of pyrexias of unknown origin in Ceylon. A preliminary report.


Clinical problems in Aviation Medicine. Disposition of the flyer who faints.


Activity of a human oculorotary muscle unit.


Fair time on hospital time.

Fair time on hospital time.


Septicemic adrenal hemorrhage.

Septicemic adrenal hemorrhage.


The regulation of pulmonary ventilation in acclimatization to altitude.


Energy cost of running.

Energy cost of running.


Kinetics and mechanism of oxygen debt contraction in man.


The relationship between sodium metabolism, verbal output and the EEG in 21 depressives.


Acrodermatitis enteropathica. Case report and review of literature.


Reiter's syndrome in children: case report and review of literature.


Sudoriferous glands of sheep and goats.

Sudoriferous glands of sheep and goats.


Ziehl-Neelsen's stain for skin sections to show wool and hair follicles.


Balloon tamponade for massive pulmonary hemorrhage.


Observations on the incidence of gallstone disease. In an attempt to ascertain whether a real increase in the incidence of gallstone disease existed at the Jewish General Hospital, Montreal, it was determined that, from 1935-1960 inclusive, 1846 gallbladder operations were performed. The operative mortality was 0.9%. The yearly trend in the number of gallbladder operations performed was generally found to be upward. Significant statistical increases were noted in 1959 and 1960. During the same years significant increases were noted in the proportion of males treated, particularly in the eighth decade of life. As a percentage of total surgical discharges, during 1960, the incidence of gallbladder operations exceeded that of appendectomies, which are being performed less frequently than previously. The peak incidence for gallbladder operations, for both sexes, occurred during the fifth decade of life. These observations suggest that in this hospital population a real increase in the incidence of gallbladder operations has probably occurred. It was not possible to form an opinion regarding possible changes in the clinical aspects of gallbladder disease.


Some structural aspects of cytochrome c function.


Interconversion of horse heart cytochrome C monomer and polymers.


Genetic fine structure of the leucine operon in Salmonella.


The mental patient who wants to fail.

The mental patient who wants to fail.


Centrally mediated inhibition of gastrointestinal propulsive motility by morphine over a non-neural pathway.


Selective inhibition of dog spinal vasoconstrictor tracts by mebutamate.


Instant ipecac.

Instant ipecac.


Activation of Hagemen Factor by saturated fatty acids.


The interrelationship of coagulation of plasma and release of peptides.


The patient-staff meeting--a technique for encouraging communication in the psychiatric hospital.


The failure syndrome and its prevention.


Hypertensive heart disease.

Hypertensive heart disease.


Parkinsonism produced by brain tumors.

Parkinsonism produced by brain tumors.


Future of neurology.

Future of neurology.


Familial schizophrenia as defined by nailfold capillary pattern and selected psychiatric traits.


Accumulation of skeletal fluoride and its implications.


Linearity and the Mach phenomenon.

Linearity and the Mach phenomenon.


Diffuse fatty degeneration of the myocardium. Report of 2 cases.


Clinical application of nerve conduction velocity (motor and sensory) and the H-reflex.


The medicolegal application of electromyography in peripheral nerve injuries.


Changes in the electro-encephalogram produced by cerebral anoxia.


Electrocardiographic evaluation of the results achieved by surgical treatment in congenital heart disease. II. Pulmonary stenosis.


Electrocardiographic evalution of the results achieved with cardiac surgery: atrial septal and endocardial cushion defects.


Clinical studies of vectorcardiography in children. II. Normal quantitative values.


Clinical studies of vectorcardiography in children. II. Quantitative values in left ventricular hypertrophy.


Protective drugs in emetine poisoning.

Protective drugs in emetine poisoning.


John Baptist D'ALBORA, 1890-1962.

John Baptist D'ALBORA, 1890-1962.


Plastic correction of double chin. Importance of the position of the hyoid bone.


Topical therapy for common hyperkeratotic lesions.


Alternative inductothermia in cancer. A confirmation with therapeutic applications of Warburg's theory.


Functional activity of the anterior pituitary after prolonged cultivation in vitro and transplantation into pituitary-deprived female rats.


Nitrogen, lipid, glycogen and deoxyribonucleic acid content of human liver. The effect of brief starvation and intravenous administration of glucose.


Profile: Dr. Clifford Grosselle GRULEE, January 3, 1880-October 24, 1962.


Silicone oil in the anterior chamber of the eye. Effect on corneal hydration.


Effect of cold on rats chronically exposed to malathion.


A new approach to haemorrhoids and allied conditions.


Spontaneous rupture of the superior mesenteric artery.


Cybernetics.

Cybernetics.


Non-insulin-producing islet cell tumours of the pancreas. A review of five cases including four with Zollinger-Ellison syndrome.


Isoniazid and wound healing.

Isoniazid and wound healing. In non-tuberculous patients with lesions exhibiting a delayed healing process oral isoniazid in doses of 3 mg./kg. was found to be rapidly effective in stimulating the wounded area to produce healthy granulation tissue. The prompt healing of these defects was accomplished by the formation of scar tissue which resisted stress in a superior manner. A topical ointment of 2% isoniazid in eucerin had a similar beneficial effect in patients with indolent skin ulcers who had failed to respond to routine treatment. Epithelialization rapidly ensued once the granulating base was established. A further series of patients with delayed wound healing and failure to respond to antibiotics or isoniazid alone showed satisfactory response when both measures were used simultaneously. It is postulated that isoniazid provides a stimulus to the growth of normal granulation tissue, may promote greater tensile strength in scars, and may be of benefit in antibiotic-resistant infections because of its ability to boost the host's normal repair mechanisms.


Injectable steroids in joint disease.

Injectable steroids in joint disease.


Purification and properties of phosphoenolpyruvate carboxylase from the germinating peanut cotyledon.


Investigation of the mechanism of enzymatic carboxylation of phosphoenolpyruvate.


A case of leukemia with myositis ossificans progressva.


The role of magnesium in the superprecipitation of myosin B.


Some observations on the neuronal mechanism of opto-kinetic nystagmus.


An evaluation of angiocardiography in pulmonary carcinoma with particular emphasis on prognosis.


Roentgen manifestations of traumatic pulmonary fat embolism.


The effect of AET (beta-aminoethylisothiuronium) on thyroid function in the rat.


An isotopic method for determination of cell generation time.


The human endothelial cell in tissue culture.


Anti-tumor effects of essential oils on crocker sarcoma 180 in mice.


Antifungal properties of perfume oils.

Antifungal properties of perfume oils.


Some metabolic and nutritional factors affecting the survival time of erythrocytes.


A combined bacteriology-pathology teaching laboratory.


The highly ingrown nail.

The highly ingrown nail.


Retrograde collateral perfusion of the abdominal viscera during excision of thoracoabdominal aneurysm.


Histochemical and manometric studies of cholinesterases in mammalian kidney tissue.


Effects of incentive magnitude on running speeds without competing responses in acquisition and extinction.


Long-term development of reinforcing properties of a stimulus as a function of temporal relationship to food reinforcement.


Effects of the chronic administration of synthetic angiotensin in rats.


Hidden waste in laundry service.

Hidden waste in laundry service.


Weaknesses in schools of x-ray technology.


Complications associated with transurethral surgery.


Cerebrospinal fluid cells and proteins following spinal anesthesia.


The medical record librarian.

The medical record librarian.


A critical look at inservice training for nursing aides.


Patterns of metastatic cancer in the spleen.


From manual to machine in medical records.


Analyses performed with heat-coagulated blood and serum. II. The determination of urea nitrogen.


Barriers to skin penetration.

Barriers to skin penetration.


Effect of pyrogallol on the catecholamine content of the rabbit brain.


Epidemiological survey of cholesterolaemia and its significance.


Recommended nutrient allowances.

Recommended nutrient allowances.


Radiological findings in choledochal cysts, with report of two cases.


The denaturation and renaturation of earthworm-cuticle collagen.


Biophysical and biochemical properties of earthworm-cuticle collagen.


Epidemiological assessment of malaria in Sheikhupura and Sialkot districts, West Pakistan during 1961-62.


Results of assessment of malaria eradication measures in West Pakistan localities adjacent to Indo-Pakistan border 1961-62.


Nutrition of animal cells in tissue culture. Studies on a synthetic medium. III.


Studies of the cardiovascular system in the hypotension of liver failure.


Pharmacological action of tyramine on the cardiovascular system in man.


A study on anoxia test.

A study on anoxia test.


Roles of external ions in the excitation-contraction coupling of frog skeletal muscle.


Studies on the relationship between the infection therapy and the reticuloendothelial system.


The impact of the training program of the National Institute of Neurological Diseases and Blindness on the specialty of neurology.


Office management of the disturbed teenager.


Abolition of ventilatory response to inhaled CO2 by neurological lesions.


The effect of inhalatory adaptation to histamine on histamine shock and the anaphylactic shock.


The need to know and the fear of knowing.


Development of serum protein spectrum during childhood.


Propionic acid as a precursor in the biosynthesis of animal fatty acids.


A new view of the failure in lipogenesis induced by fasting.


Intracranial arterial spasm related to supraclinoid ruptured aneurysms.


Reaction of I-131 anti-Rh-o(D) with enzyme treated red cells.


Role of lipogenesis in nonshivering thermogenesis.


Relation of cathartic activity to structural modifications of ricinoleic acid of castor oil.


Clinical evaluation of 1-aminocyclopentanecarboxylic acid (NSC-1026) in plasmocytic myeloma.


Waldenstrom's macroglobulinaemia observed in two brothers.


Skeletal maturation of the hand and wrist in West African children.


Humanitarian psychiatry.

Humanitarian psychiatry.


Psychiatric residency training for public institutional service.


Progress towards clean air.

Progress towards clean air.


Dose distribution problems in megavoltage therapy. I. The problem of air spaces.


The relation of function and structure in lipoyl dehydrogenase.


Medical aspects of therapy of complete heart block and cardiac arrest.


Important factors in the prevention of coronary disease.


Free amino acids in brain of mice treated with L-glutamic acid-gamma-hydrazide.


The effectiveness of a comprehensive, vocationally oriented psychotherapeutic program for adolescent delinquent boys.


Case report: dysgerminoma of left testicle, with metastasis to aortic and left inguinal nodes.


Natural history of warts. A two-year study.


Clinical assessment of analgesic drugs. (2). Observer trial.


Lipectomy: the surgical removal of excess fat.


Surveys show need for intensive care.

Surveys show need for intensive care.


Auditory organization of the inferior colliculi in the cat.


Trachoma.

Trachoma.


The syndrome of cervical aorta. Report of a case and review of the previous cases.


The state of potassium in muscle investigated by high frequency.


Interposition of the uterus between the bladder and the anterior vaginal wall. A reappraisal.


The Lown cardiovertor.

The Lown cardiovertor.


Treatment of the complications of acute coronary artery occlusion.


The treatment of "impending infarction" (premonitory phase of coronary occlusion).


Fads, public opinion, and heart diseases.


The emergency treatment of the complications of acute coronary artery occlusion.


Electrophoretic separation of biologically active constituents of scorpion venoms.


Starch-gel electrophoresis of venoms of Indian krait and saw-scaled viper and identification of enzymes and toxins.


Anti-N in a ten-week-old infant.

Anti-N in a ten-week-old infant.


Epidermoid carcinoma of the vagina.

Epidermoid carcinoma of the vagina.


A simple technic for biopsy of skin for cytogenetic investigations.


Empiric risk, genetic counseling and preventive measures in anencephaly.


Acute monilial infarction as a cause of death.


The sexual response of the human male. I. Gross anatomic considerations.


The sexual response cycle of the human female. III. The clitoris: anatomic and clinical consideration.


Collection of monkey semen by electroejaculation.


Involuntary muscle involvement (cardiac and esophageal in myotonia dystrophica. Report of case with congestive failure and atonic esophagus and a sibling with congestive failure.


Vitamin D and the intestinal absorption of iron and cobalt.


Formation of catecholamines by various areas of cat brain.


The quest for better hospital care.

The quest for better hospital care.


Separation of catecholamines and their metabolites.


Effects of substerilization doses of Co-60 gamma radiation on the cold-storage life extension of shucked soft-shelled clams and haddock fillets. Total aerobic-facultative and anaerobic (clostridia) macrocolony count data are presented, with analysis and interpretation, for both haddock fillets and shucked soft-shelled clams which received doses of from 50,000 to 800,000 rad of Co(60) gamma rays. These data indicated that haddock fillets may be maintained in good condition at refrigeration temperatures above freezing for about 1 week at 6 C, and approximately 2 weeks at 0 C, when treated with from 50,000 to 150,000 rad of ionizing radiation. In the dose range from 200,000 to 350,000 rad, the storage life may be extended up to some 2 weeks at 6 C, and 3 weeks at 0 C. Treatments in the dose range from 400,000 to 500,000 rad may defer spoilage for about 1 month, and doses of 550,000 to 650,000 rad afford protection against bacterial spoilage up to approximately 1.5 months. At the high substerilization doses of 700,000 to 800,000 rad, haddock fillets may be held for from 2 to 3 months in refrigerated storage before becoming unfit for marketing and consumption. Shucked soft-shelled clams can be held for about 2.5 weeks at 0 C and close to 12 days at 6 C, when given low substerilization doses of from 50,000 to 150,000 rad of ionizing radiation. At doses of from 200,000 to 350,000 rad, the clams may be preserved effectively for periods up to 3 weeks at 0 or 6 C, and some 6 weeks at these temperatures with doses of about 450,000 rad. With treatments of 500,000 to 600,000 rad, the storage life may be extended for some 2 months, and at doses of 650,000 to 800,000 rad the shucked clams remain in a good state of preservation for up to 3 months at temperatures of 0 to 6 C. Thus, it would appear that shucked soft-shelled clams may be maintained for significantly longer periods in refrigerated storage than haddock fillets when the same radiation treatments are applied to each product. Clostridia levels in both products were relatively low initially, and were reduced significantly by the gamma rays at the doses studied. Moreover, those clostridia that survived the radiation treatments were found to remain at safe, low levels during the various periods in refrigerated storage employed for these products, a very encouraging result from the public health, as well as commercial, standpoint.


Changes in the microflora of haddock fillets and shucked soft-shelled clams after irradiation with Co-60 gamma rays and storage at 0 C and 6 C. Frequency distribution patterns of aerobic-facultative microflora, obtained by random selection of macrocolonies from samples of haddock fillets and shucked soft-shelled clams before and after treatment with doses of from 50,000 to 800,000 rad of Co(60) gamma rays, are presented, with analyses and interpretation. The data showed that a decided change occurred in the constitution of the microbial populations of both products: from a mixed gram-negative-gram-positive flora to a predominantly gram-positive flora immediately after irradiation. The great majority of these surviving microorganisms were micrococci, sporeforming bacilli, and certain yeasts, molds, and actinomyces. During storage at refrigeration temperatures above freezing, the microflora changed from the descendants of the more radioresistant gram-positive species to the more prolific gram-negative psychrophilic species that flourish at these low temperatures. Micrococci and gram-positive rods declined somewhat during the rise of the actively proteolytic-lipolytic pseudomonads and related species, but still remained at high enough levels to contribute significantly to the spoilage observed at different times in storage. The eventual spoilage of haddock fillets was characterized by discoloration of the cream-white tissue with water-soluble yellow, green, and red bacterial pigments; degradation of the tissue, by proteolytic and other microbial enzymes, to a watery, flaccid mass; and formation of volatile compounds that smelled putrid, rancid, and generally foul and pungent. Shucked soft-shelled clams displayed a different spoilage pattern, changing to a variegated brown-gray and forming a matted or loose gelatinous mass from which arose stale, acrid, putrid, sulfurous odors. These differences are believed to be attributable to the varied biochemical nature of the tissues involved, the Eh potential within the tissues, the time sequence of microfloral change, and the species and types of microorganisms associated with each product. Staphylococci were present in small numbers in some of the samples tested, but did not appear to be species of public health significance. Gram-negative enteric rods were also encountered, but were considered to be of doubtful public health importance. More detailed investigations, designed to study the effects of Co(60) gamma radiations on such microbes in sea foods, would be useful in assessing the problem further.


A comparative neurological study on the axon reactions of amphibian motoneurons.


An experiment in teaching group psychotherapy.


A classification scheme for materials on blindness and the blind.


A classification scheme for ophthalmology.


Direct evidence for a trytophan-anthranilic acid cycle in Neurospora.


Physical culture and the intellectual worker.


Uremia in pregnancy. Emphasis on acute tubular and renal cortical necrosis.


The epithelial changes of the human cervix from the viewpoint of embryology.


A history of anesthesia.

A history of anesthesia.


Tunnelling of the distal palmar crease in the operative treatment of Dupuytren's contracture.


Pains of shanks in sportsmen.

Pains of shanks in sportsmen.


Examination howlers and English as she is writ.


Attainment of optimum health.

Attainment of optimum health. The history of the worker in public health is reviewed, his present activities are assessed, and predictions are made concerning his future role. It is emphasized that the public health specialist is but one member of the total health team in the community. His interdependence with other disciplines must be accepted if optimal health care is to be provided.Although prepared specifically for public health workers, this article has direct relevance to the future of the medical profession as a whole. In view of the present intense interest in the future pattern of health care in Canada, the viewpoint of a physician with a dual background in public health and medical school administration and teaching is considered to be particularly pertinent.


Angioma of eyelid.

Angioma of eyelid.


Correlations between relatives arising from sex-linked genes.


Non-suture closure of nephrotomy.

Non-suture closure of nephrotomy.


Antimicrobial substances from aspen tissue grown in vitro. Isolated aspen tissue, when grown in vitro for 3 weeks on agar medium, yielded antimicrobial substances which produced inhibitory zones when the culture plates were inoculated with Fusarium roseum, Saccharomyces cervisiae, Bacillus subtilis, Bacillus cereus, Penicillium, roqueforti, Torula utilis, Sarcina lutea, Flavobacterium aquatile, Pullularia pullulans, and Staphylococcus aureus.


The localization and properties of anaminopeptidase in Escherichia coli B.


An improved method of separating amino acids as N-2,4-dinitrophenyl derivatives.


The quantitative isolation of valine from amino acid mixtures as its dinitrophenyl derivative.


Enterotomy and decompression for intestinal distension.


Contrast radiography: an aid to postoperative management.


Emotional aspects of a hospitalised patient.


Virus-induced acquisition of metabolic function. VI. Dihydrofolate reductase, a new phage-induced enzyme.


Closed-chest cardiac massage in the newborn infant.


Computing economical ordering quantities.


Vitamin A and carotene utilization in protein-deprived rats.


Acid mucopolysaccharides of frog cartilage in thyroxine-induced metamorphosis.


Comparative study of lethal photosensitization of Sarcina lutea by 8-methoxypsoralen and by toluidine blue. Mathews, Micheline M. (Department of Bacteriology, University of California, Berkeley). Comparative study of lethal photosensitization of Sarcina lutea by 8-methoxypsoralen and by toluidine blue. J. Bacteriol. 85:322-328. 1963.-A comparative study has been made of the photo-killing of Sarcina lutea by 8-methoxypsoralen (8-MOP) and by toluidine blue. It has been found that photosensitization by 8-MOP differs from photosensitization by toluidine blue, in that it has a temperature coefficient of less than one, and that the presence of oxygen is not necessary for, and even is deleterious to, the photosensitization, the psoralen being destroyed by its presence. It has previously been shown that the presence of carotenoid pigments protects the cells of S. lutea from lethal photosensitization by toluidine blue; it was found that the presence of these pigments has no protective effect in photosensitization with 8-MOP. Studies on the lethal photosensitization of S. lutea with toluidine blue suggested that the primary sensitive site of the photokilling was the protein of the cell membrane, as manifested by the destruction of membrane enzyme activity and the regulation of permeability. It has been found that photokilling by 8-MOP has no effect on these functions. A study was made on the effect of photokilling by 8-MOP on the production of penicillin-resistant mutants as an indication of an alteration in the cellular deoxyribonucleic acid (DNA) by the psoralen. Psoralen photosensitization resulted in the development of many penicillin-resistant mutants. On the basis of the findings reported in this paper, it is suggested that photosensitization of S. lutea by 8-MOP does not reflect damage to cellular protein, as does toluidine blue, but rather damage to cellular DNA.


Failure of activated trypsin to cause experimental acute hemorrhagic pancreatitis.


The pharmacology of pain control.

The pharmacology of pain control.


Science for the citizen: an educational problem.


Polyostotic fibrous dysplasia.

Polyostotic fibrous dysplasia.


Traumatic arterial injuries.

Traumatic arterial injuries.


The Billroth-I recurrent ulcer.

The Billroth-I recurrent ulcer.


An approach to elderly patients for general physicians.


Adenomyosis uteri. A pathologic study of 290 cases.


Laryngeal involvement in pulmonary tuberculosis.


Studies on the histopathological changes induced by DDT in the liver, kidney, and intestine of certain fishes.


Blood pressure studies in the adult population of Agra, India.


A case of carcinoma of both upper lids.

A case of carcinoma of both upper lids.


A case of proptosis.

A case of proptosis.


Effect of prednisolone in the experimentally induced nephropathy in male albino rats.


Immuno-allergic concept of nephritis.

Immuno-allergic concept of nephritis.


Peptic ulcer and asymptomatic spontaneous pneumothorax in a case of chronic bronchial asthma on prolonged steroid therapy.


Studies on the serum glutamic oxalecetic and serum glutamic pyruvic transaminases, and cardiac muscle transaminases in experimental myocardial infarction in dogs.


Natural history of aortic atherosclerosis.


Correlation of the extent and severity of coronary atherosclerosis to serum cholesterol.


Validity of serum lipid determinations on post-mortem blood.


Correlation of the extent and severity of atherosclerosis in the coronary and cerebral arteries.


Variety, developmental stage and dose rate in irradiation of the potato.


Intra-epithelial melanoma of cornea.

Intra-epithelial melanoma of cornea.


An outbreak of brucellosis in Bhiwani. The danger of infection with Brucella melitensis.


Binocular summation at the absolute threshold of peripheral vision.


Kinetics of the alkali denaturation of hemoglobin in the single erythrocyte.


Denaturation of ferritin and its relationship with hemosiderin.


New uses for membrane filters II. Isolation of auxotrophic mutants.


A comment on the fertility of F2 donor types of Escherichia coli K12.


New uses for membrane filters III. Bacterial mating procedure.


Outbreak of epidemic typhus in the northern region of Saudi Arabia.


On rationalization of family formation in Israel.


Lactic-dehydrogenase isoenzymes.

Lactic-dehydrogenase isoenzymes.


Pain in orofacial region associated with coronary insufficiency. Report of a case.


Distribution of hereditary blood antigens among Indians in Middle America. II. Tzotzil and other Maya.


The amino acid sequence of human heart cytochrome c.


The replication process of single stranded DNA of bacteriophage phi X174. II. The non-intermediation of the double stranded DNA as a material precursor.


Comparative biochemical studies. II. Amino acid composition and some properties of human cytochrome c.


X-ray examination with an improved x-ray television unit.


Studies on riboflavin in cerebrospinal fluid. 2. On riboflavin contents in cerebrospinal fluid of tuberculous meningitis, purulent meningitis and Japanese encephalitis.


Effect of bilateral ablation of the habenular nucleus on thyroid function in the albino rat.


Neural control of ACTH secretion: effect of acute decerebration in the rat.


b-Nucleic acid, and the initial step of deoxyribonucleic acid-degradation by deoxyribonuclease I.


Electron microscopy of tobacco mosaic virus particles from aphid stylets.


Chemical constituents of the alkaloid-free fraction from opium.


Pathology of lymphatic leukemia.

Pathology of lymphatic leukemia.


Investigation on a test of histocompatibility for allogeneic grafts. II. A study on rabbits.


Effects of vitamin A supplement in infancy.


Metabolism of the heart muscle. Effects of epinephrine, insulin and hydrocortisone on the C14-labeled glucose and palmitate-1-C14 metabolism of the normal rat heart muscle.


Immunological studies of tumors. VI. Some cytochemical studies on the effect of antisera upon human cells in tissue culture.


Mourn the death of Dr. Naomi ARAKI, President of Chiba University (1897-1962).


The preparation of hyaluronic acid from bovine synovial fluid.


Dynamic visco-elastic properties of glycerol-extracted muscle fibers.


Studies on the cyclopentadienide anion.

Studies on the cyclopentadienide anion.


Studies on agglutination and haemolysis of sheep erythrocytes by Lactobacillus antiserum.


Inheritance of haptoglobin types in 51 Japanese families.


Statistical observations on 115 autopsied cases of traffic accidents.


Endocrinological studies on acute intestinal obstruction (clinical and experimental studies).


Biosynthesis of sinigrin.

Biosynthesis of sinigrin.


The depletion of catecholamine of the rabbit's atria by reserpine in vitro.


The uptake of noradrenaline by the isolated rabbit's atrium treated with reserpine.


Biological effect of high and low oxygen tension--a morphological study.


Designated comment on the action and the use of anticoagulant.


The effect of x-irradiation on 5-hydroxytryptamine (serotonin) contents in the small intestines of experimental animals.


Studies on the life history of the hookworms. V. The morphological studies on the development of the 2d and 3d stage larvae of Ancylostoma duodenale and Necator americanus.


Influence of low temperature, sunshine, desiccation and human excreta upon the eggs of Ancylostoma duodenale and Nacator americanus. I. Low temperature.


The regulatory mechanism of enzyme synthesis in the tryptophan biosynthetic pathway of Escherichia coli K-12.


Specialized transduction of tryptophan markers in Escherichia coli K12 by bacteriophage phi-80.


Multiplicity of carcinoma and sarcoma of rat liver.


Lingual cancer with myocardial metastasis.


The incorporation of C14-glycine into the soluble RNA of the posterior silkgland.


Sodium bicarbonate: increase in survival rate of rats inhaling oxygen. The injection daily of 50 milliters of 0.15M sodium bicarbonate per kilogram of body weight significantly decreased the mortality rate of rats inhaling 95-to 98-percent oxygen. This treatment did not prevent the occurrence of degenerative changes in the germinal epithelium of the tests.


Evaluation of oliguria and edema in acute experimental burns with the use of urea.


Experiments with skin transplantation, runt disease, and parabiosis in a new inbred rat strain.


Relationship between survival time and size of homografts in rats.


Studies on the sites and kinetics of Coxsackie A9 virus multiplication in the monkey kidney cell.


Experimental studies with reference to antigen-antibody phenomena following severe extensive burns.


Postural assistance for oedema and varicosities.


Acute epiglottitis.

Acute epiglottitis.


The injection of epinephrine during general anesthesia with halogenated hydrocarbons and cyclopropane in man.


Combination therapy for relief of anxiety and depression.


Studies on the physiology of Rickettsiae. IV. Folic acids of Coxiella burnetii. Mattheis, Martha S. (University of Kansas, Lawrence), M. Silverman, and D. Paretsky. Studies on the physiology of rickettsiae. IV. Folic acids of Coxiella burnetii. J. Bacteriol. 85:37-41. 1963.-Yolk, yolk sac, and embryo tissues of uninfected eggs, and those infected with Coxiella burnetii, were analyzed for folic acid derivatives by employing diethylaminoethyl (DEAE)-cellulose column chromatography. Infected tissues contained quantitatively less folate, but the elution profiles of both infected and uninfected tissues were identical. Purified C. burnetii contained some types of folate apparently unique to these rickettsiae, and not found in infected tissue. The major folate fraction of C. burnetii was partially characterized by (i) elution position from DEAE columns; (ii) treatment with conjugase; (iii) growth response by Lactobacillus casei, Streptococcus faecalis R, and Pediococcus cerevisiae; and (iv) response to oxidation, reduction, and formylation.


Hydrogen transfer in fatty acid synthesis by rat liver and mammarygland cell-free preparations studied with tritum-labeled pyridine nucleotides and glucose.


Influence of enzymic activities on substrate oxidations in normal and diabetic rat liver and in mammary gland homogenate fractions.


Bibliotherapy gives a new lease on life.


Aminomalonate as an enzyme inhibitor.

Aminomalonate as an enzyme inhibitor.


Effects of hormones, placental extracts and hypophysectomy on inulin and para-aminohippurate clearances in the anaesthetized rat.


Double-blind trials of promazine in labour.


Purification and properties of a dihydrolipoic dehydrogenase from Spinacia oleracea.


Serum vitamin B12 in renal failure.

Serum vitamin B12 in renal failure. The serum vitamin B(12) level was abnormally high in 14 out of 32 cases of renal failure. This was probably due to impaired excretion of the vitamin, but the results of measurements of the rate of excretion of radioactive vitamin B(12) did not provide unequivocal evidence on this point; other possible explanations are discussed. Renal failure must be added to the causes of high serum B(12) levels.


Hospital supplies in disaster.

Hospital supplies in disaster.


Emergency health supplies: present status of procurement and control. Until recently there was no substantial reserve of health supplies in Canada capable of supporting major peacetime or wartime disasters. In 1952, an $18,000,000 stockpile was authorized by the Federal Government of Canada. Purchases were made to a total of $15,500,000 with deliveries to exceed $13,000,000. Over $6,000000 worth of supplies was distributed to eight regional depots across Canada in safe and strategic locations. Plans were made for release and control of supplies to provincial governments for use at all levels of control, and a Resources Planning Unit has been organized. In Canada, undergraduate students in pharmacy receive special civil defence instruction in emergency health supplies service.


Steroids. 223. Color reagent for steroids in thin-layer chromatography.


Steroids. CCXV. The quantitative analysis of steroids by thin-layer chromatography.


Steroids, CCXI. Centrifugally accelerated paper partition chromatography of steroids.


The management of the cardiac arrhythmias.


The differentiation of two types of fusimotor fibre by their effects on the dynamic response of muscle spindle primary endings.


Kinetics of labelling of turnip yellow mosaic virus with P32 and S35.


A possible role for minor bases in ribonucleic acid.


Further studies on the neuropharmacological effects of etryptamine acetate.


A theory concerning imprinting.

A theory concerning imprinting.


The pharmacology of chlorphenesin carbamate, a centrally active muscle relaxant.


Change that searching to a "finding system".


The lethaldose, pressor effect and intestinal activity of some pyrrolidine N-substituted Nornicotine derivatives.


Nuclear protein synthesis in Vicia faba.


Nomenclature and the malaria entomologist.


Workshop on graduate education.

Workshop on graduate education.


Population increases in Culex pipiens fatigans Wiedemann. A review of present knowledge. The author reviews the growing body of evidence that urban populations of Culex pipiens fatigans have increased extensively during recent years in both Africa and Asia. Two main factors seem to be responsible-the spread of urbanization, providing favourable habitats for this essentially urban mosquito; and the increasing use of residual insecticides, leading to disregard of conventional sanitary measures and a consequent proliferation of suitable culicine breeding-places. In addition, it is possible that the use of insecticides may be bringing about a selective destruction of less resistant competitors of C. fatigans.Present knowledge of this species is too exiguous to allow of a full understanding of the reasons for its increase, to assess its significance in relation to disease transmission, or definitively to adopt economical and practicable control methods. However, a number of possible lines of approach to this problem are suggested.


Some considerations relating to the role of Culex pipiens fatigans Wiedemann in the transmission of human filariasis. This paper is concerned mainly with the relationship between microfilarial periodicity and vector periodicity. The so-called "non-periodic" Pacific form of Wuchereria bancrofti in fact shows a well-marked and relatively constant periodicity. The amplitude of this periodicity is low, which may account for the difficulty of detecting it in small clinical samples. The periodicity is well adapted to the biting cycle of Aëdes polynesiensis, though less so than that of the "semi-periodic" Brugia malayi to forest Mansonioides. Microfilarial periodicity is discussed in the light of recent work on circadian rhythms in other animals and it is suggested that certain possibilities have been given insufficient weight. The use of the term "migration" to describe microfilarial translocation within the host may have given rise to misunderstanding but it is in good agreement with current concepts of migration. Recent work suggests some behavioural heterogeneity in Culex fatigans which could render it a useful mosquito for elucidating certain important but little-understood problems.


Some aspects of medical rehabilitation including an account of Garston Manor Rehabilitation Centre.


The fetal electrocardiogram. A new research tool.


Reduction of adrenochrome by ascorbic acid.


The surgical treatment of rhinophyma. An analysis of fifty-seven cases.


Glutaric acid accumulation by a lysine-requiring yeast mutant.


Betamethasone enemata in ulcerative colitis. In this series a very large therapeutic dose of corticosteroid was administered by retention enemata. For the first week the author gave the equivalent of between 300 and 750 mg. of cortisone daily and for the next three weeks 150 to 375 mg. daily. The results were excellent but systemic effects were noted in all who received more than the smallest dose used.


Small intestine transit time studied in patients with the dumping syndrome.


Adrenal cortical and pituitary function after intrarectal steroid therapy.


Permeability and respiration effects of thyroidal hormones on the isolated bladder of the toad Bufo bufo.


Live measles-virus vaccine: clinical trial of vaccine prepared from a variant of the Sugiyama strain adapted to bovine kidney cells.


Active sodium transport in response to thyroxine.


Contemporary idea of Schoenlein Henoch disease hyperergic vasculitis in children.


Collagen diseases in children.

Collagen diseases in children.


Indirect massage of the heart.

Indirect massage of the heart.


The clinical characteristics and treatment of the acute leucoses in children.


Evidence against presence of chromaffin cells in human skin.


Coexistent carcinoma and scleroderma of esophagus.


Zollinger-Ellison syndrome.

Zollinger-Ellison syndrome.


A functional outpatient desk.

A functional outpatient desk.


In vivo study of cell kinetics in acute leukaemia.


Comparison of potency estimates for glucocorticoids using two thymolytic assay procedures.


'The road to recovery': the patient's point of view.


Further observations on the pathogenesis of congenital glaucoma.


Alan Churchill WOODS (1889-1963).

Alan Churchill WOODS (1889-1963).


Graduated supination-pronation. Attachments for table and floor looms.


Immunity in the tortoise Testudo ibera.

Immunity in the tortoise Testudo ibera.


Gastro-intestinal haemorrhage: surgical management.


Respirator spore trap.

Respirator spore trap.


The benefits of bargaining.

The benefits of bargaining.


Antigenicity of polypeptides (poly alpha amino acids). X. Studies with polymers of D amino acids.


Antigenicity of polypeptides: immunological unresponsiveness to copolymers of gamma-amino acids. Immunological tolerance toward three synthetic random copolymers of the alpha-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.


Antigenicity of polypeptides (poly alpha amino acids). VII. Studies in humans. It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis. The immediate skin reactivity appeared not to be related to the P-K antibody. The delayed reaction was histologically distinct from the immediate reaction and consisted of perivascular lymphocytic infiltration in contrast to the predominantly polymorphonuclear cells in the latter reaction. The antigenic response against the polymers resembled that observed with proteins. From cross-reactions it appears that the response is heterogeneous in the sense that not all individuals react against the same groupings in the complex polymers.


Nature of antigenic determinants in proteins and synthetic polypeptides.


DNA synthesis and mitotic rate in leukaemic cells.


A new objective fluorophotometer.

A new objective fluorophotometer.


Clinical physiology of the cornea.

Clinical physiology of the cornea.


Disulphide-sulphydryl exchange in dough.


Metabolic evidence for suppression of Paget's disease of bone by aspirin.


Synthesis of D1-alpha-(dihexanoyl-,dioctanoyl-, and didecanoyl)-phosphatidyl D-1-serines.


Glomerular structure in proteinuria.

Glomerular structure in proteinuria.


The utility of the angle atd in dermatoglyphics.


Correlations between ridge-counts on all digits of the Parsis of India.


Quantitative analysis of finger ridge counts of the Parsi community in India.


Superior mesenteric-artery stenosis treated by iliac-mesenteric arterial bypass.


Observations on experimental occlusion of the superior mesenteric artery.


Problems in mesenteric infarction.

Problems in mesenteric infarction.


Motor nerve conduction velocity measurement as a diagnostic tool.


The effect of 4-methyltropolone on the metabolism of adrenaline.


Short-chain fatty acid (C6,C8,C10) phosphatidyl ethanolamines.


The uptake of some sulphur-containing amino acids by a brewer's yeast.


Selection of unbalanced and unusual designs by children high in curiosity.


Fate of transplanted bone.

Fate of transplanted bone.


Pressor effects of adrenaline, noradrenaline and reflex vasoconstriction sensitised by low concentrations of ganglion blocking drugs.


Studies of carotid blood flow in unilateral occlusion.


Fine structure of the urinary mucoprotein of Tamm and Horsfall as revealed by systematic depolymerization.


Urinary mucopolysaccharides and calculi.


Lipid mobilization following carbon tetrachloride administration.


Treatment of corneal disease with 5-iodo-2'-deoxyuridine (IDU). A clinical evaluation of 500 cases.


Stabilities of some alkaline earth chelates of tetracycline.


Observations concerning the effects of a thioxanthine upon the heart of the intact animal.


Further observations on the pharmacology of 1,1-dimethyl-4-phenyl piperazinium iodide as studied in the intact dog.


Phonocardiography as a foetal heart monitor.


Hemodynamic studies of a monoamine oxidase inhibitor, DL-serine-N2-isopropylhydrazide (RO 4-1038). Mechanism of hypotensive action.


Observations pertinent to antihypertensive mechanisms of MAO inhibitors using DL-serine isopropylhydrazine.


Clinical and experimental pharmacology of sympathetic blocking agents.


Observations on the mechanism of fibrinolysis in a two phase system.


Modified fibrinolytic technique for analysis of the plasmin system.


Clinical nursing content in the graduate program.


Hemodynamic effects of arterial stenosis.


Critical arterial stenosis.

Critical arterial stenosis.


The mental nurse in the community.

The mental nurse in the community.


Future of district psychiatry.

Future of district psychiatry.


Planning for increasing leisure. Problems of town and country.


Restoring the psychiatrically disabled to the community.


A follow-up study of hermaphrodites after their reconstruction and rehabilitation.


The bibliography of Erich LEXER's scientific work.


Pulmonary operations in emphysematous patients. Although emphysema itself is a disease of the entire lungs and so is not amenable to surgical therapy, there are many conditions in emphysematous patients in which surgical operation can be quite helpful-for example, some complications of emphysema and some conditions not etiologically related to emphysema but affecting the lungs. Among these conditions are infectious diseases (pneumonia, bronchiectasis, tuberculosis and infected bullae) and other conditions such as spontaneous pneumothorax, the presence of space-occupying bullae and carcinoma. The surgical treatment required may range from suction or drainage to wide resection.


Diverticulitis.

Diverticulitis.


Bacteriology of sputum in chronic bronchitis.


A new admission procedure.

A new admission procedure.


Admitting a patient is therapy.

Admitting a patient is therapy.


Stimulus selection in preschool children under conditions of free choice.


Positive interracial grafts of embryonic thyroids implanted into the eye of adult mice.


Intra-articular hip fusion with the intramedullary nail.


Review of use of radioisotopes in Australia in research on growth regulators and herbicides.


The management of ocular emergencies in general practice. II. Emergencies not due to injury.


Therapeutic abortion in North Carolina.

Therapeutic abortion in North Carolina.


Proteolytic mechanism in recurrence of Arthus-type inflammation by thiol compounds.


Patient, hospital, and family doctor: a survey in one practice.


Lymphography of deep trunks of the legs.


Declining severity of first attack of rheumatic fever.


Enzymatic oxalate determination in urine.


Medical education and the organization of medical care in the USSR.


Nutrition and lactation.

Nutrition and lactation.


Obesity.

Obesity.


Nutrition in the aged.

Nutrition in the aged.


Nutrition and celiac disease.

Nutrition and celiac disease.


Old intrapleural hematoma with recent superior vena caval obstruction. A case report.


The spatial vectorcardiogram in peri-infarction block.


Action of epinephrine on glucose uptake and glucose-6-phosphate in the dog heart in situ.


Two variants of tick-borne encephalitis virus showing different plaque morphology.


Dissociation of the augmentation of cardiac contractile force from the activation of myocardial phosphorylase by catecholamines.


Early man in the Andes.

Early man in the Andes.


Evaluation of glycolytic and citric acid cycles in homogenates of dystrophic mouse muscle.


Who speaks for physiology?

Who speaks for physiology?


The lymphatic system with particular reference to the kidney.


Postpartum hemorrhage.

Postpartum hemorrhage.


The lymphatic system.

The lymphatic system.


Blood glucose and plasma unesterified fatty acid changes induced by the stress of an emergency situation.


Studies on bovine gastrointestinal parasites. XXV. Duration of egg production of Cooperia punctata, Trichostrongylus axei, and Oesophagostomum radiatum.


The effect of thyroid administration on the pancreatic amylase activity of hypophysectomized and intact rats.


The estimation of hemorrhagic tendency in the blood vessels of the hamster cheek pouch.


Lymph and lymphatics.

Lymph and lymphatics.


Infectious hepatitis at Fort Yukon, Alaska-report of an outbreak, 1960-1961.


Trichinosis in Alaska. A review and report of two outbreaks due to bear meat with observations on serodiagnosis and skin testing.


Monoamine oxidase inhibition by ethanol in vitro.


Resection of colon or rectum for malignant disease in elderly patients.


Lipoma of the alimentary tract.

Lipoma of the alimentary tract.


Malignancy of colon and rectum in patients under 30 years of age.


Postcolectomy enteritis: survival after extensive small bowel resection complicated by magnesium deficiency--case report.


The hazy horizon: a critical evaluation of current practices in psychosocial rehabilitation.


Intrathoracic neuroblastoma in a newborn infant.


Report of the President's Panel on Mental Retardation.


Biophysical studies on the nature of the simian papova virus particle (vacuolating SV40 virus).


Acrolein--a fine structure fixative for viral cytochemistry.


Immunofluorescent, cytochemical, and microcytological studies on the growth of the simian vacuolating virus (SV-40) in tissue culture.


The virus of Teschen disease.

The virus of Teschen disease.


Radium and radon retention in mice.

Radium and radon retention in mice.


Simulataneous hypoprothrombinemia, indirect hyperbilirubinemia, and diabetes mellitus. Report of a case.


Infantile diarrhea due to enteropathogenic Escherichia coli.


Principles of personnel management. I. The question of status the problem of responsibility.


The five year hospital service development program of the Department of Health.


A modern concept in medical care.

A modern concept in medical care.


Anagram solution times: a function of word length and letter position variables.


Indications and contraindications for prosthetic speech appliances in cleft palate.


On the submicroscopical changes of the segmenting ovum in the albino rat.


Coronary arterial and other intravascular thromboses treated with fibrinolysin. Experimental and clinical results.


The volunteer in relation to activity programs for the institutionalized aged.


Cardiovascular effects of the synthetic oxytocin Syntocinon.


Enzymes of DNA synthesis in nuclei of sea urchin embryos.


Studies of thiaminase action: Hammett's rho-sigma treatment.


Metabolism of propionic acid in animal tissues. IX. Methylmalonyl coenzyme A racemase.


Relation of ferritin iron to heme synthesis in marrow and reticulocytes.


Metabolism of propionic acid in animal tissues. X. Methylmalonyl co-enzyme A mutase holoenzyme.


The importance of biopsy of non-palpable scalene nodes in bronchogenic carcinoma.


Studies on rapidly frozen suspensions of yeast cells by differential thermal analysis and conductometry. Few, if any, yeast cells survived rapid cooling to -196 degrees C and subsequent slow warming. After rapid freezing, the suspensions absorbed latent heat of fusion between -15 degrees and 0 degrees C during warming, and the relation between the amount of heat absorbed and the concentration of cells was the same as that in equivalent KCl solutions, indicating that frozen suspensions behave thermally like frozen solutions. The amount of heat absorbed was such that more than 80 per cent of the intracellular solution had to be frozen. The conductometric behavior of frozen suspensions showed that cell solutes were still inside the cells and surrounded by an intact cell membrane at the time heat was being absorbed. Two models are consistent with these findings. The first assumes that intracellular freezing has taken place; the second that all freezable water has left the cells and frozen externally. The latter model is ruled out because rapidly cooled cells do not shrink by an amount equal to the volume of water that would have to be withdrawn to prevent internal freezing.


On the tentative role of infectious viruses in tumour etiology.


Further study of haemocytoblastosis-reticulosis virus of mice.


Effects of intense or prolonged stimulation on systole.


Effects of the application of norephinephrine upon the common carotid.


The cardiac catheterization laboratory in the private hospital.


Gross and chromosomal cytology of virus infected Chinese hamster cells.


Long-term support of intact skin in organ cultures, with application to study of virus infection.


Triethylene thiophosphoramide in the prevention of pterygium recurrence.


Effect of gamma irradiation on pigs fed low vitamin A rations.


A different project in postgraduate psychiatric education.


De Quervain's subacute granulomatous thyroiditis: histological identification and incidence. The histological features of de Quervain's subacute granulomatous thyroiditis are described, on the basis of a study of six specimens. This condition, unlike Hashimoto's disease, rarely causes permanent hypothyroidism; its histological identification is thus of practical importance. Areas of thyroid affected by the disease show intrafollicular cellular infiltration, with partial or complete loss of colloid from infiltrated follicles, partial or complete disruption of their lining epithelium, and abnormalities of the basement membrane. These changes tend eventually to lead to replacement of the damaged follicle by a granuloma-like structure devoid of colloid content and without a recognizable epithelial lining. The disease also causes interfollicular fibrosis and an interstitial inflammatory cell reaction. The histological pattern is typically multiform. Formative follicle lesions present a striking appearance, aiding recognition of the disease. Some follicles contain numerous giant cells, often grouped around a central pool of residual colloid; others may contain a considerable proportion of neutrophil polymorphs or show radially aligned spindle-shaped cells.A study has also been made of the incidence of de Quervain's thyroiditis in surgical material in Sheffield during the seven year period 1955-61. Only two examples were found in a total of 1,282 cases of primary thyroid disease, an incidence of 1.6 per 1,000 (0.16%); there is, however, reason to believe that the overall clinical incidence is higher than that indicated by the surgical figures.


Sexual problems.

Sexual problems.


Factors limiting depth of a maximal inspiration in human subjects.


The control of respiratory frequency.

The control of respiratory frequency.


Diabetic acidosis with pancreatic artery thrombosis: unusual complication of carcinoma of the pancreas.


Alpha oxidation of the brain fatty acids.


Enzymatic decarboxylation of the alphahydroxy acids by brain microsomes.


A 1 carbon degradation of the long chain fatty acids of brain sphingolipids.


Totem and Taboo reconsidered with respect.


A century of the abuse of rest.

A century of the abuse of rest.


Surgery or radiotherapy for tonsil cancer?


Adenomata of the adrenal gland.

Adenomata of the adrenal gland.


Some thoughts on hospital administration.


A simplified method for immuno-assay of human serum insulin.


Effect of motivation and progress on the estimation of longer time intervals.


Terminal retardation in activity gradients.


Treatment of nutritional cirrhosis in rats with choline and methionine; with special reference to fibrogenesis and fibroclasia.


Orthopedic surgeons on tour.

Orthopedic surgeons on tour.


Age and marital status--and their relationship to success in practical nursing.


Family occupational background and previous work experience and their relationship to success in practical nursing.


Function of a community psychiatric clinic.


Problems of the novice interviewer.

Problems of the novice interviewer.


Community mental health and mental hospital collaboration.


Clinical comparison of cast gold crowns with acrylic and with fused porcelain veneer facings.


The myeloproliferative disorders.

The myeloproliferative disorders.


Hand problems: avoiding the pitfalls in an office practice.


Postoperative rupture of the esophagus.

Postoperative rupture of the esophagus.


Football head injuries.

Football head injuries.


Anesthesia for otologic surgery.

Anesthesia for otologic surgery.


Presentation of the Kober medal for 1962 to William Bosworth CASTLE.


Horace MANN-pioneer in health education.


Monilial granuloma treated with amphotericin B.


A new type of oral contraceptive.

A new type of oral contraceptive.


Orthoptics in the ordinary practice.

Orthoptics in the ordinary practice.


Chemical contraceptive trial. II.

Chemical contraceptive trial. II.


Heat stable human plasma protein fractions electrophoretically rich in albumin.


A Surgical Peace Corps.

A Surgical Peace Corps.


Alteration of bone metabolism in tissue culture in response to parathyroid extract.


Factors associated with attitudes favorable to rehabilitation among committed alcoholic patients.


Some implications of illness behavior for medical sampling.


The localization of the thalamo-cortical and cortico-thalamic fibres in the internal capsule and thalamus of the cat.


Effects of deprivation upon counting and timing in rats. Two procedures were used in an investigation of the effects of deprivation upon counting and timing. Under the first procedure, fixed minimum interval (FMI), the rat received liquid reinforcement every time it pressed bar B after having waited a minimum of 5 sec following a press on bar A. Under the second procedure, fixed consecutive number (FCN), reinforcement was delivered every time the rat pressed bar B following a run of at least four consecutive responses on bar A. Water deprivation was varied over a set of values ranging from 4 to 56 hr. Deprivation had almost no effect on the waiting time in the FMI procedure, or on the number of responses per run in the FCN procedure. With both procedures, increasing deprivation shortened the pause between reinforcement and the next response. In the FCN procedure, the speed with which the runs were executed increased with increasing deprivation, although the number of responses in these runs was relatively unaffected.


A fixed interval schedule in which the interval is initiated by a response. The fixed interval schedule described requires the animal to initiate every time interval by making a response on a bar other than the one on which it is reinforced. This response, R(A), demarcates the postreinforcement pause (S(R)-R(A) interval) from the fixed interval pause (R(A)-R(B) interval) so that these pauses may be measured separately. Twelve rats and three monkeys, working in two-bar Skinner boxes, were trained and stabilized on this schedule. The resulting performances, presented for individual animals, are analyzed in terms of (1) the relative frequencies with which the animal waits various lengths of time between consecutive responses, (2) the relative frequencies with which various rates of responding appear, (3) the change in response rate throughout the fixed interval, (4) the average length of the postreinforcement pause, (5) the relative frequencies with which the animal waits different lengths of time between the R(A) and the first R(B), and (6) the average inter-response time as a function of the rank order in the fixed interval of the inter-response time. The joint interpretation of the several measures taken leads to the following conclusions: 1. The probability of an R(B) increases throughout the fixed interval. 2. The increase is discontinuous at the first R(B), at which point the probability increases sharply. 3. The frequency distributions of R(A)-R(B) pauses exhibit three discrete types of behavior with no intermediate cases. 4. The (main) mode of R(A)-R(B) interval length usually occurs just below the fixed interval requirement.


Behavioral effects of caffeine, methamphetamine, and methylphenidate in the rat. It was possible to distinguish three closely-related psychomotor stimulants, caffeine, methamphetamine, and methylphenidate, by means of two operant behavior procedures, fixed interval and fixed number. Under the fixed interval procedure, the percentage change in the number of R(B)s per reinforcement was significantly smaller with caffeine than with methamphetamine or methylphenidate (p < .001). Under the fixed number procedure, the percentage change was significantly smaller with methamphetamine than with caffeine or methylphenidate (p < .001). Thus, methylphenidate had a methamphetamine-like effect under fixed interval and a caffeine-like effect under fixed number.


Practical aspects of levoangiography; review of three hundred and twenty-three examinations.


Infective hepatitis. Individual, familial, and neighbourhood aspects.


The use of antigenic tissue extracts to weaken the immunological reaction against skin homografts in mice.


Persistence of tin-113 in slightly decalcified mouth enamel.


Influenza and cardiopulmonary disease. II.


Influenza and cardiopulmonary disease. I.


Patient waiting-time as an index of medical care.


Photoelastic stress analysis of forces opposing withdrawal of impressions.


Dr. Paul Christian SWENSON (1901-1962).

Dr. Paul Christian SWENSON (1901-1962).


Clinical applications of chromosome analysis.


Biperiden in the treatment of phenothiazine-induced extrapyramidal reactions.


The in vivo effects of hydrazines and vitamin B6 on the metabolism of gamma-aminobutyric acid.


The relation between parental prescriptions for child and parent roles.


The relation between inter-parent agreement and several child measures.


The consistency of inter-parent agreement on several measures.


An examination of several correlates of sociometric status in a first grade group.


Objective responsibility in children: a comparison with the Plaget data.


Chorea and bacterial endocarditis.

Chorea and bacterial endocarditis.


Research creativity in psychology graduate students.


Ease of concept attainment as a function of associative rank.


Mothers' retrospective reports in child-rearing research.


Intracranial disorders of the newborn infant.


Electric countershock for ventricular tachycardia and fibrillation in the depressed heart.


Wick systems in circular paper chromatography.


Studies on the influence of spleen tissue on the growth of some experimental tumours. I. Experiments with the "portalization of the splenic vein" in rats inoculated with MR-leukaemia.


Investigations on the influence of spleen tissue on the growth of some experimental tumours. II. The effect of spleen homotransplants on the transplantability of MR-leukaemia.


Changes in cellular deoxyribonucleic acid in mouse skin following application of a tumor-promoting agent.


Extensive severe burn treated with enzymatic debridement and microdermagrafting: case report.


A review of long-stay psychiatric patients.


Nucleolar size and total ribonucleic acid in ascites tumour cells.


Localization of thiamine pyrophosphatase activity in the golgi apparatus of a mollusc, Helix aspersa. Spermatids of the snail Helix aspersa were studied after fixation in buffered osmium tetroxide and after applying Novikoff and Goldfischer's method (15) for demonstrating thiamine pyrophosphatase (TPPase) activity both with the light and the electron microscope. The appearance of cells in the light microscope after localizing the enzyme is very similar to the appearance after the application of classical Golgi techniques. The electron microscope shows the "dictyosomes" to consist of non-granular membranes, vesicles, and vacuoles typical of the ultrastructure of the Golgi apparatus. Sites of TPPase activity are localized by deposits of lead phosphate, and are found between the membranes of the Golgi apparatus, in the small vesicles, in multivesicular bodies often found associated with it, but not within the large Golgi vacuoles. Heavy deposits are found on the caudal part of the nuclear envelope, but not in the acrosomal granule. It is suggested that TPPase may act as an intermediary in acrosome formation by the Golgi apparatus or "acroblast" of this cell. The finding of diphosphatase activity in the Golgi apparatus of an invertebrate is suggested as additional evidence for the existence of a homology between the Golgi apparatus of all animal cells.


Cortical bone atrophy and osteoporosis as a manifestation of aging.


The skin as an organ of diagnosis.

The skin as an organ of diagnosis.


The treatment of infantile eczema with fluocinolone acetonide cream.


Aerial disinfection with hexyl resorcinol in a monkey house.


Photos preference test (PPT) as a measure of mental status for hospitalized psychiatric patients.


Experiments on the radioprotective action of dimethyl sulphoxide.


Reading block and television apathy: an alarm for parents.


The concept of psychopathy.

The concept of psychopathy.


Delayed mourning in victims of extermination camps.


Neurologism and denial of psychic trauma in extermination camp survivors.


Four hundred years of "witchcraft," "projection" and "delusion".


The reflex of surrender and capitulation.


Intestinal parasites among food handlers in Montreal, Quebec, and vicinity.


Energy transformation in the heart.

Energy transformation in the heart.


Acute retention following abdominoperineal resection for carcinoma of the rectum.


A simple method for concentrating phototactic flagellates and separating them from debris.


Effect of altitude upon tolerance of rats to vibration stress.


Thiamine-sparing action of mustard and role of coprophagy.


Storage of tissue thiamine and its intestinal synthesis in hypo- and hyper-thyroid rats.


The uptake of As74-labeled arsonoazoproteins in tissues of tumor-bearing mice.