PROPERTIES OF VARIOUS ANTI-GAMMA-GLOBULIN FACTORS IN HUMAN SERA. The serological and physicochemical properties of the following three forms of human anti-gamma-globulin factors were compared: (a) rheumatoid factors; (b) Milgrom type anti-gamma-globulin factors; and (c) factors directed against an antigen in human gammaG-globulin that is hidden in the intact molecule and revealed by enzymatic digestion at low pH. The property common to these factors is ability to interact with human gammaG-globulin; they are distinguishable because they react with different antigenic groups on this molecule. In all of five sera, the Milgrom type anti-gamma-globulin factors were gammaM-globulins. They reacted with various human gammaG-globulin antibodies but failed to interact with gammaM-globulin type antibodies in agglutination and absorption experiments. When isolated from other anti-gamma-globulin factors, they agglutinated red cells coated with intact anti-Rh antibodies, but failed to react with cells cells coated with pepsin-digested anti-Rh antibody. These observations indicate that the agglutinator reacts with the crystallizable, inert fragment of gammaG-globulin. Anti-gamma-globulin activity directed against an antigen in human gammaG-globulin revealed by pepsin digestion was demonstrated in gammaG-, gammaA-, and gammaM-globulins. This anti-gamma-globulin factor could be absorbed by antigen-antibody precipitates containing human antibody, which shows that the hidden antigen in human gammaG-globulin is revealed not only by enzymatic digestion at low pH, but also when gammaG-globulin is present as antibody in an antigen-antibody precipitate. Rheumatoid factors and Milgrom type anti-gamma-globulin factors were also absorbed by antigen-antibody precipitates containing human antibody. The results indicate that the three distinct forms of antigamma-globulin factors may all be produced as a result of antigenic stimulation by autologous antigen-antibody complexes.


THE EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS ON CELLULAR AND SUBCELLULAR MEMBRANES. The mouse isoantigens determined at the major histocompatibility locus known as H-2 have been found to be closely associated with the cellular surface membranes, with the membranes of the endoplasmic reticulum, and probably with those of the lysosomes as well. Mitochondrial membranes, on the other hand, show little or no H-2 antigen activity. Membrane material prepared from certain tissues, including brain and muscle, have no detectable H-2 antigenic activity. Evidence is presented which indicates that all of the H-2 antigens of the genome are expressed as a unit, supporting the hypothesis that the complex H-2 genetic locus consists of a single cistron. It is postulated that these histocompatibility antigens form some structural or functional unit in the membranes of cells.


THE EFFECT OF ANTISERUM, ALONE AND WITH HYDROCORTISONE, ON FOETAL MOUSE BONES IN CULTURE. 1. The effects of normal rabbit serum and of rabbit antiserum to whole foetal mouse tissues, on the isolated limb bones of late foetal mice were studied in organ culture, and the influence of hydrocortisone on these effects was investigated. 2. Unheated normal serum caused slight loss of metachromatic material from the cartilage matrix, and some resorption of both cartilage and bone. 3. In unheated antiserum to foetal mouse tissues, the terminal cartilage was smaller and less metachromatic than in paired controls in normal serum, while osteoclasis was so intense that in many explants the bone had almost disappeared. The amount of necrosis varied with different batches of antiserum. 4. The changes produced by normal serum and antiserum could be largely prevented by heating the sera to 57 degrees C for 45 minutes. 5. The effects could also be inhibited by the addition of hydrocortisone to the unheated sera; as little as 0.1 microg hydrocortisone per ml of medium had a well marked protective action. 6. It is suggested that (a) unheated antiserum causes a release of lysosomal enzymes with consequent breakdown of intercellular material, (b) this release is due to an indirect action on the lysosome via an increased permeability of the cell membrane, (c) hydrocortisone does not affect the antigen-antibody reaction, but inhibits the autolytic changes that normally follow this reaction, possibly by stabilising both the lysosomal and cell membranes.


INDIVIDUAL ANTIGENIC SPECIFICITY OF MYELOMA PROTEINS. CHARACTERISTICS AND LOCALIZATION TO SUBUNITS. The specific antigenic structure of individual myeloma proteins was investigated for the presence of similar antigenic determinants in pooled gamma-globulin and for the localization of these determinants on the gamma-globulin molecules. Quantitative precipitin analyses demonstrated that in most instances absorption of antisera specific for an individual myeloma protein with large amounts of gamma-globulin markedly reduced or completely removed the reactivity of the antiserum for the homologous myeloma protein. In only one instance did strong specificity remain after absorption with 100 mg of Fr II per cc of antiserum. The antigenic determinants responsible for the individual specificity were localized in all cases studied solely to the Fab fragment produced by papain digestion. After reductive cleavage, three patterns of localization were observed. Individual specificity could be localized either to; (a) isolated heavy chains, (b) isolated light chains, (c) antigenic determinants present only when light and heavy chains were recombined. After immunization with whole myeloma proteins, individual specificity was localized in part at least to the isolated heavy chain in four of six proteins studied. It was localized to the light chains in three of five type L proteins but in none of six type K proteins. In the instances where individual specificity of the myeloma protein was present on the light chains, it was shown that the Bence Jones protein from the same patient also contained the individual specificity. Immunization with isolated heavy or light chains furnished further evidence for the individual specificity of both types of chains. These studies on myeloma proteins furnished evidence concerning the portions of the gamma-globulin molecule subject to individual antigenic variation. The light chains, particularly the L type and the Fd portion of the heavy chains were primarily involved. Evidence for the importance of the quaternary structure was also obtained from the necessity in some instances for light and heavy chains to be associated in order for individual specificity to be observed. The Fc fragment of the heavy chains on the other hand showed very limited variation which was related to subgroup specificity.


CELLULAR SITES OF SYNTHESIS OF RABBIT IMMUNOGLOBULINS DURING PRIMARY RESPONSE TO DIPTHERIA TOXOID-FREUND'S ADJUVANT. The present studies are based on previous observations that the intravenous injection of diphtheria toxoid and complete Freund's adjuvant into rabbits resulted in an increased proliferation of cells associated with antibody synthesis; an accelerated, enhanced, and prolonged synthesis of antibody; and a lengthened interval between the appearance of gammaM- and gammaG-hemagglutinating antibodies in the circulation. The molecular species of antibodies that were synthesized by fragments of the spleens were determined by the incorporation of labeled amino acid into antibody and by binding of radioactive antigen by antibody. These studies were paralleled by determination of the presence and type of antibody within the cell by immunofluorescence. Evidence was obtained that non-phagocytic mononuclear cells in the walls of the sinusoids of the red pulp of the spleen are a major source of 19S gammaM-antibody and plasma cells in the non-follicular white pulp are a major source of gammaG-antibody. The data did not exclude the synthesis of gammaG-antibodies by the mononuclear cells, the synthesis of gammaM-antibodies by the plasma cells, or the synthesis of both antibodies by an occasional cell of either morphology. It was hypothesized that the 19S and 7S antibody responses evolved independently with the development of at least two different cell types, a mononuclear cell with capacity for 19S immunoglobulin synthesis and a plasma cell with capacity for 7S immunoglobulin synthesis.


INDUCED UNRESPONSIVENESS TO SIMPLE ALLERGENIC CHEMICALS. II. INDEPENDENCE OF DELAYED-TYPE HYPERSENSITIVITY AND FORMATION OF CIRCULATING ANTIBODY. Normal guinea pigs fed chemical haptens develop a specific state of unresponsiveness, inhibiting subsequent development of dermal sensitization with the same hapten and modifying profoundly the synthesis of anaphylactic antibody in response to hapten conjugated to guinea pig proteins. The degree of unresponsiveness has been tested by exposing hapten-fed animals to intense haptenic stimulation. Animals of groups that were demonstrably unresponsive to picryl chloride could be made to form hapten-specific antibody by injecting picrylated bovine gamma globulin. Specific anaphylactic-type antibodies, presumably 7S gamma(1), were synthesized, and in animals given PBGG adsorbed to alumina there arose a measurable concentration of precipitating antibody, presumably 7S gamma(2), perhaps slightly earlier than in similarly treated control animals. Attempts to impose contact-type reactivity on such unresponsive animals met with limited success. Injection of picrylated guinea pig erythrocyte stromata in a complete Freund's adjuvant, with subsequent applications of picryl chloride to the dermis, led to definite contact sensitivity to 0.3 per cent picryl chloride, whereas parallel treatment of normal control animals induced sensitivity to 0.006 or 0.002 per cent. By this double method of stimulation, hapten-fed animals did not advance in sensitivity by reason of the secondary dermal applications of the simple chemical, whereas control animals developed increasingly higher sensitivity by these contacts in what appeared to be a stepwise manner. Picryl chloride-fed guinea pigs injected intradermally with picryl chloride either after or before forming picryl-specific circulating antibody still remained unable to develop picryl-specific contact hypersensitivity. Control animals synthesizing picryl-specific antibody subsequently responded to intradermal injection of picryl chloride with contact-type sensitivity. Interpretations of these results are discussed and the view is presented that delayed-type hypersensitivity and circulating antibodies of the varieties measured here are formed independently of each other.


STUDIES ON IMMUNOLOGIC RECONSTITUTION OF THYMECTOMIZED MICE. 1. Immunologic function, growth, and longevity of neonatally thymectomized mice was restored by intraperitoneal administration of 100 to 400 million syngeneic, hemiallogeneic, or ailogeneic thymus cells from newborn or adult donors. Assays of the graft versus host capabilities of spleen cells from the animals restored with allogeneic cells showed that their immunologically competent cells are of donor histocompatibility characteristics. Such animals accepted skin grafts from mice of the cell donor strain, but rejected skin from a third strain. 2. Similar results were obtained when the neonatally thymectomized animals were treated with 10 to 100 million syngeneic, hemiallogeneic, or allogeneic cells from adult spleen. 3. In one strain combination, C(3)H recipients and A donors, injected thymus or spleen cells apparently attacked host tissues, since the animals died very early of wasting disease. When this combination was reversed, A strain recipients treated with C(3)H cells were reconstituted immunologically and physiologically. 4. Syngeneic or allogeneic adult spleen, grafted in the newborn period, reconstituted neonatally thymectomized mice, but all experiments involving grafting of newborn spleen failed. Immunogenetic analysis of the host spleen cells from two allogeneic spleen-grafted animals previously thymectomized showed that the reconstitution was entirely of donor histocompatibility characteristics. 5. Postthymectomy wasting disease was reversed by administration of 200 million adult syngeneic spleen or thymus cells. Immunologic recovery was confirmed by graft versus host assays of the spleens of the recovered animals and by application of allogeneic skin grafts. Some of the animals have been under observation for 42 weeks and appear to be normal. 6. The wasting syndrome in neonatally thymectomized mice was also reversed by injection of 200 million hemiallogeneic or allogeneic spleen cells. 7. Thymus grafts did not reverse wasting disease, whether the donors were adult or newborn, of the same strain or a different one. 8. Spleen, lymph node, and Peyer's patches from representative animals of the reconstituted groups were examined and compared with the tissues of untreated neonatally thymectomized mice and intact animals of the same strain. Tissues of normal cellularity and follicular organization were found in some of the reconstituted animals and also in mice with reversed wasting disease. Extreme deficit of the lymphoid tissues was rare in either group.


OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCCI. IV. STUDIES  ON THE MECHANISM OF LYSIS BY CELL-BOUND HEMOLYSIN OF RED BLOOD CELLS AND EHRLICH ASCITES TUMOR CELLS. In studies of the mechanism of lysis of red blood cells by washed streptococci with hemolytic activity (cell-bound hemolysin, CBH) no components released spontaneously by RBC or streptococci, or by interaction between these cells, could be found to induce the formation of soluble hemolysin by the streptococci. It was also found that separation of RBC from streptococci even by Millipore filter or a very thin layer of agar could prevent their hemolysis. By means of cellulose columns it was possible to separate RBC from streptococci after a short incubation. RBC thus separated from streptococci with which they had been incubated underwent hemolysis on subsequent incubation at 37 degrees C. By varying the period of incubation prior to separation it was possible to demonstrate the transfer of increasing amounts of hemolysin from streptococci to RBC with increasing periods of incubation. A considerable part of this appeared to be at a constant rate. A theory is presented on the relationship between the streptococcal cell-bound hemolysin and the group of oxygen-stable streptococcal hemolysins, in terms of a transferable hemolytic moiety and binding sites for this moiety on the streptococcal cell, on various molecular species which can act as inducers of the oxygen-stable hemolysins, and on the RBC, with the affinity of the respective binding sites for the hemolytic moiety increasing in that order.


CYTODYNAMICS IN THE RESPIRATORY TRACT.

CYTODYNAMICS IN THE RESPIRATORY TRACT.


PULMONARY EMBOLISM AND INFARCTION.

PULMONARY EMBOLISM AND INFARCTION.


LUNG TRANSPLANTATION: A RESUME.

LUNG TRANSPLANTATION: A RESUME.


SARCOIDOSIS.

SARCOIDOSIS.


MILIARY TUBERCULOSIS IN CHILDREN.

MILIARY TUBERCULOSIS IN CHILDREN.


RADIOGRAM OF THE VAS DEFERENS DURING CYSTOGRAPHY.


BENIGN HODGKIN'S DISEASE (PARAGRANULOMA).


CARBOPOL 934P, A VERSATILE UNIQUE DRUG RELEASE AGENT.


CHOLEDOCHOTOMY AND USES OF T-TUBE DRAIN.


PANCREATIC FISTULA FOLLOWING BIOPSY.

PANCREATIC FISTULA FOLLOWING BIOPSY.


DUODENAL STASIS AND DILATATION; REPORT OF FOUR CASES.


REPAIR OF INCISIONAL MIDLINE HERNIA AND DIASTASIS OF RECTI MUSCLES.


THE PROBLEM IN THE MANAGEMENT OF BLEEDING PEPTIC ULCER.


EYE DISEASE FROM NATURAL AND MAN-MADE RADIATION.


CONSERVATIVE TREATMENT IN FRACTURE-SEPARATION OF THE PROXIMAL HUMERAL EPIPHYSIS: REVIEW OF THE LITERATURE AND REPORT OF TWO CASES.


POLLICINIZATION OF THE MIDDLE FINGER; REPORT OF A CASE.


CYSTIC LEIOMYOMA OF THE RECTUM; REPORT OF A CASE AND REVIEW OF THE LITERATURE.


MEDICAL CARE OF THE AGED.

MEDICAL CARE OF THE AGED.


PEDIATRIC PROBLEMS OF TEEN-AGE PARENTS.

PEDIATRIC PROBLEMS OF TEEN-AGE PARENTS.


TREATING DIFFICULT-TO-MANAGE EDEMATOUS HYPERTENSIVE PATIENTS WITH HYDROCHLOROTHIAZIDE.


PERSISTENT EOSINOPHILIA FOLLOWING ACCIDENTAL INGESTION OF CHLORAMBUCIL.


THE EPIDEMIOLOGY OF LEPTOSPIROSIS IN LOUISIANA.


PROBLEMS IN DIAGNOSIS AND TREATMENT OF ATHLETIC INJURIES.


MUSIC THERAPY FOR THE PSYCHIATRIC PATIENT.


LOUISIANA STATE MEDICAL SOCIETY: OFFICERS; COMPONENT SOCIETIES, 1965.


PSYCHODYNAMICS AS REFLECTED IN THE LOWENFELD MOSAIC TEST.


A FACTOR ANALYSIS OF THE F AND REVERSED F SCALES IN THREE REGIONAL SAMPLES.


SOCIAL DISTANCE WITHIN AND BETWEEN CASTES AND RELIGIOUS GROUPS OF COLLEGE GIRLS.


ATTITUDE CHANGE AND COMMUNICATION-ATTITUDE DISCREPANCY.


SITUATIONAL VARIABLES IN SOCIALLY DEVIANT BEHAVIOR.


THE USE OF A HOSPITAL VOLUNTEER PROGRAM IN THE TEACHING OF ABNORMAL PSYCHOLOGY.


THE DIFFUSION OF INFORMATION WITHIN SECONDARY SCHOOL STAFFS.


EXPRESSED VALUES OF BURMESE AND AMERICAN UNIVERSITY STUDENTS.


THE EFFECT OF COMPETITION ON THE SPEED AND ACCURACY OF SYLLOGISTIC REASONING.


DISPLACEMENT AND ORALITY IN TIV WITCHCRAFT.


TEMPORAL OPINION ORIENTATION: AN ADAPTIVE PROCESS.


CREATIVITY IN THE CRIMINAL.

CREATIVITY IN THE CRIMINAL.


A SPECIFICATION EQUATION FOR PREDICTING TREATMENT RESPONSE.


PERSONALITY IMPRESSIONS OF SELF-PUNITIVE AND EXTRAPUNITIVE STIMULUS PERSONS.


BIRTH ORDER AND SUBJECT RECRUITMENT.

BIRTH ORDER AND SUBJECT RECRUITMENT.


MENTAL DISORDER AND STATUS: A RESEARCH NOTE.


SOCIAL REFERENTS AND SELF-EVALUATION IN EXAMINATIONS.


TRANSFUSIONAL HEMOSIDEROSIS RESEMBLING HEMOCHROMATOSIS: REPORT OF A CASE FOLLOWING 406 TRANSFUSIONS.


PHYSIOLOGIC CONSIDERATIONS IN THE DIAGNOSIS AND MANAGEMENT OF SHOCK.


THE NOTION OF REALITY IN FREUD'S ANALYSIS OF RELIGION.


INTRINSIC FACTOR AND B12 ABSORPTION--A PROBLEM IN CELL PHYSIOLOGY.


THE EFFECTS OF A BALANCED LUNCH PROGRAM ON THE GROWTH AND NUTRITIONAL STATUS OF SCHOOL CHILDREN.


PLASMA TURBIDITY AND DISEASE.

PLASMA TURBIDITY AND DISEASE.


A POSSIBLE INDIRECT MEASURE OF DIETARY INTAKE.


CANCER METASTASES AND BLOOD COAGULATION.


SALT SUPPLEMENTATION DURING FASTING IN THE COLD.


ALCOHOLIC HYPOGLYCEMIA.

ALCOHOLIC HYPOGLYCEMIA.


THE EFFECT OF DIET ON RAT LIVER ENZYMES.


CHOLESTEROL ESTERS EXCLUDED FROM INTESTINAL ABSORPTION.


FATTY ACID COMPOSITION OF FISH OILS.

FATTY ACID COMPOSITION OF FISH OILS.


"TRANSFORMATION" OF LYMPHOCYTES BY BEAN EXTRACTS.


THE EFFECT OF FAT SOLUBLE VITAMINS ON THE ERYTHROCYTE MEMBRANE.


FETAL DEATH FROM NICOTINAMIDE DEFICIENCY.


THE EFFECT OF CHANGES IN THE DIETARY LEVEL OF LINOLEATE AND LINOLENATE ON THE COMPOSITION OF RAT LIVER FATTY ACIDS.


FATIGUE AND THE PHYSICAL ENVIRONMENT.

FATIGUE AND THE PHYSICAL ENVIRONMENT.


PHYSIOLOGICAL ASPECTS OF WORK MEASUREMENT.


OCULOMOTOR DYSFUNCTION AS THE ORIGIN OF SOME DISORDERS OF EQUILIBRIUM;  THERAPY BY MEANS OF PRISMATIC CORRECTION.


INDICATIONS FOR MYRINGOTOMY.

INDICATIONS FOR MYRINGOTOMY.


SCHOLASTIC UNDERACHIEVEMENT IN CHILDHOOD.


PREMATURE INFANT FEEDING. I. THE CLINICAL USEFULNESS OF CALORIC CONCENTRATION OF FORMULAS, OF EARLY VERSUS LATE FEEDINGS AND OF LOW STEARIC ACID CONTENT FORMULAS.


PREMATURE INFANT FEEDING. II. THE IN-UTERO GRID METHOD FOR EVALUATING WEIGHT GAIN IN PREMATURE INFANTS.


PREMATURE INFANT FEEDING. IV. THE LIFE-DEATH SCORE: A METHOD FOR EVALUATING NEWBORN INFANT SURVIVAL.


ROENTGENOLOGIC MANIFESTATIONS OF GASTRIC AND DUODENAL ULCERS IN CHILDREN.


HYPOGLYCEMIC CONVULSIONS IN CHILDREN AFTER ALCOHOL INGESTION.


THE AVAILABILITY OF THE CALCIUM AND PHOSPHORUS OF PLANT MATERIALS FOR ANIMALS.


BREAD AND OTHER FOODS OF PLANT ORIGIN AS A SOURCE OF IRON.


RELATIVE AVAILABILITY OF STRONTIUM IN FLOUR AND MILK.


THE IMPORTANCE OF HYPOCALCAEMIA IN THE DEVELOPMENT OF HYPOMAGNESAEMIC TETANY.


RENAL MECHANISMS OF POTASSIUM DEPLETION.


THE ROLE OF THE KIDNEY IN SODIUM AND POTASSIUM BALANCE IN THE COW.


MINERAL AVAILABILITY AND TECHNIQUES FOR ITS MEASUREMENT.


FACTORS WHICH AFFECT THE AVAILABILITY OF MAGNESIUM.


THE INSTITUTIONALIZED, THE INSTITUTION-PRONE AND THE INSTITUTION.


YUROK SHAMANISM.

YUROK SHAMANISM.


FOREIGN MARRIAGES IN THE MILITARY.

FOREIGN MARRIAGES IN THE MILITARY.


SYMBOLICAL SELF-STRANGULATION IN A TRANSVESTITE SCHIZOPHRENIC.


GROUP METHODS IN THE PHARMACOTHERAPY OF CHRONIC PSYCHOTIC PATIENTS.


PATIENT VARIABILITY AS A FACTOR IN GROUP ACTIVITIES ON A MAXIMUM SECURITY WARD.


A CRITIQUE OF TWO RECENT THEORIES OF HYPNOSIS: THE PSYCHOANALYTIC THEORY OF GILL AND BRENMAN CONTRASTED WITH THE BEHAVIORAL THEORY OF BARBER.


THERAPEUTIC APPROACHES TO PROJECTION; SOME LIMITATIONS OF THE CLASSICAL VIEW.


MOTIVATIONAL COMPONENTS IN THE INTERPERSONAL TRANSACTIONS OF MARRIED COUPLES.


THERAPEUTIC ELEMENTS IN OUT-PATIENT MUSIC THERAPY.


SUBJECTIVE COMPLAINTS, PSYCHIATRIC TESTIMONY, AND ATTORNEY'S TACTICS IN HANDLING AN ADVERSE WITNESS.


SICK STRIP.

SICK STRIP.


MEDICAL SELF-HELP TRAINING PROGRAM.

MEDICAL SELF-HELP TRAINING PROGRAM.


PSYCHOLOGIC COMPARISONS BETWEEN WOMEN WITH RHEUMATOID ARTHRITIS AND THEIR NONARTHRITIC SISTERS. I. PERSONALITY TEST AND INTERVIEW RATING DATA.


MEDICAL SELF-HELP DEMONSTRATION PROJECT IN DAVIS COUNTY, UTAH.


DIFFERENTIAL CHARACTERISTICS OF MEDICAL IN-PATIENTS REFERRED FOR PSYCHIATRIC CONSULTATION: A CONTROLLED STUDY.


COMPARISON OF HEAF AND MANTOUX TESTS IN THE CALI AREA OF COLOMBIA.


ENVIRONMENT IS EVERYBODY'S BUSINESS.

ENVIRONMENT IS EVERYBODY'S BUSINESS.


APPLICATION OF FA TECHNIQUES TO DETECTION OF CLOSTRIDIUM PERFRINGENS.


A COMPARISON OF BEHAVIORAL RATINGS AND HEART RATE MEASUREMENTS IN HUMAN NEONATES.


SOCIAL FACTORS AFFECTING EMOTIONALITY AND RESISTANCE TO DISEASE IN ANIMALS. V. EARLY SEPARATION FROM THE MOTHER AND RESPONSE TO A TRANSPLANTED TUMOR IN  THE RAT.


PSYCHOLOGIC COMPARISONS BETWEEN WOMEN WITH RHEUMATOID ARTHRITIS AND THEIR NONARTHRITIC SISTERS.  II. CONTENT ANALYSIS  OF INTERVIEWS.


EFFECT OF RESTRAINT ON FREE FATTY ACID MOBILIZATION IN  RATS.


NATIONAL SURVEY OF BLOOD PRESSURE AND HEART DISEASES IN JAPAN.


BODY PERCEPTION AND SYMPTOM LOCALIZATION.


KEEPING PUNCHCARD RECORDS IN A MASS IMMUNIZATION.


SCINTILLATION SCANNING OF BONE TUMOURS AND METASTASES BY THE USE OF SR 85.


DRUG-SET INTERACTION: PSYCHOLOGICAL AND PHYSIOLOGICAL EFFECTS OF EPINEPHRINE UNDER DIFFERENTIAL EXPECTATIONS.


MECHANISMS OF PSYCHOSOCIAL ADJUSTMENT IN PATIENTS SEEKING " FACE-LIFT" OPERATION.


CALORIMETRIC MEASUREMENTS OF RADIATION ABSORPTION.


AN ESTIMATION OF THE NECESSITY FOR PHYSICS IN THE TRAINING OF THE RADIOGRAPHER.


"THIS WON'T HURT". HANDLING THE PEDIATRIC PATIENT.


A PRACTICAL VISUAL AID X-RAY TEACHING UNIT.


ISOTOPIC METHODS FOR THE DETERMINATION OF BLOOD VOLUME.


A REVIEW OF TECHNIQUE DEVELOPMENT: MAMMOGRAPHY, XEROMAMMORADIOGRAPHY, AND THERMOMAMMOGRAPHY.


CELL TRANSFORMATION IN XENOPLASTIC TRANSPLANTATION OF AN AMPHIBIAN LYMPHOID TUMOUR.


CONGENITAL HEART DISEASE AND LIFE INSURANCE.


PRESSURES AND PULSES.

PRESSURES AND PULSES.


DETECTION OF ORAL HYPOGLYCEMIC AGENTS IN URINE.


DETECTION OF ORAL HYPOGLYCEMIC AGENTS IN UINE.


DETECTION OF ANTIHYPERTENSIVE AGENTS IN URINE.


THE CHANGING SCENE IN MEDICAL AND INSURANCE RELATIONS.


THE URINARY FINDINGS OF INSURANCE APPLICANTS.


HETEROGENEOUS CRITICISM AND PRAISE.

HETEROGENEOUS CRITICISM AND PRAISE.


ATRIO-VENTRICULAR HEART BLOCK: UNIVERSITY OF MANITOBA FOLLOW-UP STUDY REPORTS--SERIES 1963.


THE PROGNOSTIC SIGNIFICANCE OF NON-SPECIFIC T-WAVE CHANGES IN THE CHEST LEADS IN AN INSURED POPULATION.


MEDICAL INFORMATION BUREAU.

MEDICAL INFORMATION BUREAU.


SURGICAL TREATMENT OF ARTERIOSCLEROSIS: LATE RESULTS.


"MEDICINE AND INSURANCE".

"MEDICINE AND INSURANCE".


LIFE INSURANCE MEDICAL RESEARCH FUND.

LIFE INSURANCE MEDICAL RESEARCH FUND.


VIRUSES AND CANCER--A REVIEW.

VIRUSES AND CANCER--A REVIEW.


THE PHYSICAL AND MENTAL CONDITIONS OF ASTRONAUTS DURING AND IMMEDIATELY FOLLOWING SPACE FLIGHT.


HE TRANSMISSION OF ELECTROCARDIOGRAMS BY TELEPHONE.


SCREENING CARDIOGRAMS BY ELECTRONIC MEANS.


COMBINED PROPERATIVE IRRADIATION AND SURGERY FOR CANCER OF THE HEAD AND NECK.


PRESENT STATUS OF THE DECOMPRESSION OPERATION FOR MALIGNANT EXOPHTHALMOS.


THE SMALL BLOOD VESSELS OF THE CONJUNCTIVA AND NAILFOLD IN VASOMOTOR RHINOPATHY.


THE VIENNA CLINIC.

THE VIENNA CLINIC.


THERAPEUTIC PROBLEMS IN KERATITIS.

THERAPEUTIC PROBLEMS IN KERATITIS.


II. YELLOW FEVER.

II. YELLOW FEVER.


REPRESSION OF THE C2 AND C3 CISTRONS OF PHAGE LAMBDA IN A LYSOGENIC BACTERIUM.


CHARACTERISTICS OF ANTIGENS AND ANTIBODIES ASSOCIATED WITH THE PRUNUS NECROTIC RINGSPOT VIRUS IMMUNE SYSTEM.


IMMUNOFLUORESCENCE STUDIES ON SYNTHESIS AND DISTRIBUTION OF TOBACCO MOSAIC VIRUS ANTIGEN IN TOBACCO.


THE STRUCTURE OF VISNA VIRUS STUDIED BY THE NEGATIVE STAINING TECHNIQUE.


DEMONSTRATION OF A PORCINE ADENOVIRUS BY ELECTRON MICROSCOPY.


STIMULATION OF THE INCORPORATION OF CHOLINE IN POLIOVIRUS-INFECTED CELLS.


THE FATE OF THE INOCULUM IN HELA CELLS INFECTED WITH POLIOVIRUS.


REARRANGEMENT OF TOBACCO MOSAIC VIRUS SUBUNITS DURING DRYING.


THE FINE STRUCTURE OF FOAMY VIRUS.

THE FINE STRUCTURE OF FOAMY VIRUS.


THE ULTRACYTOCHEMISTRY OF ESCHERICHIA COLI B CELLS INFECTED BY BACTERIOPHAGE T2.


THE FINE STRUCTURE OF GLADIOLUS VIRUS.

THE FINE STRUCTURE OF GLADIOLUS VIRUS.


THE ROLE OF THE RETICULOENDOTHELIAL SYSTEM IN INTERFERON FORMATION IN THE RABBIT.


DETERMINATION OF RIBONUCLEIC ACID CONTENT OF SPHERICAL VIRUSES FROM SEDIMENTATION COEFFICIENTS OF FULL AND EMPTY PARTICLES.


INACTIVATION OF SOUTHERN BEAN MOSAIC VIRUS BY ULTRAVIOLET LIGHT.


MECHANISM OF INHIBITION OF CELLULAR DNA SYNTHESIS BY PSEUDORABIES VIRUS.


OBSERVATIONS ON THE GROWTH OF MOUSE HEPATITIS VIRUS (MHV-3) IN MOUSE MACROPHAGES.


THE INTERACTION OF NEWCASTLE DISEASE VIRUS AND NEUTRALIZING ANTIBODY.


EVIDENCE OF GENETIC RECOMBINATION IN FOOT-AND-MOUTH DISEASE VIRUS.


THE LATENT PERIOD OF PEA-ENATION MOSAIC VIRUS IN THE PEA APHID, ACYRTHOSIPHON PISUM (HARRIS)--AN APPROACH TO ITS ESTIMATION.


SPECIFIC COMPLEMENT-FIXING ANTIGENS IN POLYOMA TUMORS AND TRANSFORMED CELLS.


BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION. 8. ANALYSIS OF PROTEIN SYNTHESIS.


SUPPRESSION OF VIRUS INFECTIVITY IN DISEASED PLANT TISSUE FOLLOWING TREATMENT WITH AN ANTIVIRAL FACTOR FROM VIRUS-INFECTED PLANTS.


THE USE OF ANTIVIRAL CHEMICALS TO PROTECT PLANTS AGAINST SOME VIRUSES TRANSMITTED BY APHIDS.


STUDIES ON THE LYSIS OF ESCHERICHIA COLI C BY BACTERIOPHAGE PHI-X174.


DOUBLE HETEROGENOTES FORMED BY P1-MEDIATED TRANSDUCTION OF LAC GENES IN ESCHERICHIA COLI.


DECLINE OF SPECIFIC INFECTIVITY OF COWPEA CHLOROTIC MOTTLE VIRUS IN VIVO.


STUDIES OF THE LIVER FUNCTION IN EXPERIMENTAL BURNS. V. THE RADIOIODINE ROSE BENGAL (RIRB) TEST IN NORMAL AND BURNED RABBITS, RESULTS OF EXTERNAL AND INTERNAL MEASUREMENTS.


THE CORPUS LUTEUM-HYPOPHYSIS RELATIONSHIP. THE LUTEOLYTIC EFFECT OF LUTEINIZING HORMONE (LH) IN THE RAT.


THE CORPUS LUTEUM-HYPOPHYSIS RELATIONSHIP. THE EFFECTS OF PROGESTERONE AND OESTROGEN ON THE SECRETION OF LUTEOTROPHIN AND LUTEINIZING HORMONE IN THE RAT.


THE EFFECT OF A SINGLE LARGE DOSE OF 9-ALPHA-FLUOROPREDNISOLONE ON NUCLEODEPOLYMERASE ACTIVITY AND NUCLEIC ACID CONTENT OF THE RAT THYMUS.


INFLUENCE OF VARIOUS STEROIDS ON TESTES AND ACCESSORY SEX ORGANS IN THE RAT.


A SIMPLE BLOOD TRANSFUSION TECHNIQUE IN THE UNANAESTHETIZED MOUSE. PRELIMINARY RESULTS ON BLOOD CORTICOTROPHIN AND THYROTROPHIN MEASUREMENTS.


QUANTITATIVE RELATIONS IN THE AQUEOUS FLARE RESPONSE INDUCED BY ALPHA-MELANOCYTE STIMULATING HORMONE IN THE RABBIT EYES.


STUDIES ON GROWTH HORMONE SECRETION IN RATS WITH THE HYPOPHYSIS AUTOTRANSPLANTED TO THE KIDNEY CAPSULE.


THE EXTRACTION OF PROLACTIN FROM HUMAN PITUITARY GLANDS.


SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION.


STUDIES WITH GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM HUMAN PLACENTA.


INFLUENCE OF GONADOTROPHIC HORMONES ON THE DECIDUAL CELL REACTION IN INTACT AND IN HYPOPHYSECTOMIZED RATS.


TPNH GENERATION IN THE HUMAN OVARY.

TPNH GENERATION IN THE HUMAN OVARY.


METABOLISM OF OESTRONE AND OESTRADIOL IN THE HUMAN FOETO-PLACENTAL UNIT AT MIDPREGNANCY.


THE OESTROGENIC AND ANTIFERTILITY ACTIVITIES OF DIETHYLSTILBOESTROL AND DIMETHYLSTILBOESTROL IN RODENTS.


ANTIOESTROGENIC ACTIVITY IN FAHLI CLOVER HAY AND OAT HAY.


A PRACTICAL METHOD FOR ESTIMATION OF URINARY PREGNANEDIOL AND ALLOPREGNANEDIOL USING THIN LAYER CHROMATOGRAPHY.


SMALLPOX VACCINATION AND SERUM ANTI-A LEVELS.


GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY IN A DUTCH FAMILY.


DISTRIBUTION OF THE GC TYPES IN NORWAY.

DISTRIBUTION OF THE GC TYPES IN NORWAY.


DERMAL CONFIGURATIONS IN THE DIAGNOSIS OF THE DOWN SYNDROME: AN ATTEMPT AT A SIMPLIFIED SCORING METHOD.


STUDIES ON THE GC SYSTEM IN FINNS AND LAPPS.


A DEVIATING GC TYPE.

A DEVIATING GC TYPE.


THE DISTRIBUTION OF TRANSFERRIN VARIANTS IN SOUTH-WESTERN FINLAND AND IN FINNISH LAPPLAND.


THE INHERITANCE OF THE RADIALLY CURVED LITTLE FINGER.


FURTHER OBSERVATIONS ON EAR LOBE ATTACHMENT.


HOMOSEXUALITY AND VENEREAL DISEASES.

HOMOSEXUALITY AND VENEREAL DISEASES.


THE RELATION BETWEEN THE LUCIO PHENOMENON AND CUTANEOUS  ALLERGIC VASCULITIS (RUITER). REPORT OF TWO IMPORTED CASES OF NECROTIZING VASCULITIS IN LEPROMATOUS PATIENTS SEEN IN THE NETHERLANDS.


REPORT OF A SYSTEMATIC SURVEY OF ANIMAL RINGWORM IN HUMANS AND CATTLE.


THE PLASTICITY OF RESPONSE PATTERNS IN HOST-SEEKING MOSQUITOES.


TREATMENT OF ACUTE TOXOPLASMOSIS IN WHITE MICE WITH SPIRAMYCIN.


THE SPECIFICITY OF SABIN AND FELDMAN'S DYE TEST IN THE DIAGNOSIS OF TOXOPLASMOSIS.


MALARIA PROBLEMS ARISING FROM THE CONSTRUCTION OF A RESERVIOR IN THE INTERIOR OF SURINAM.


ON INTESTINAL PROTOZOA IN THE URBAN AND BUSHLAND POPULATION IN SURINAM.


"WITKOP" OR "WHITEHEAD" IN NIGERIA.

"WITKOP" OR "WHITEHEAD" IN NIGERIA.


THE DETECTION UNDER FIELD CONDITIONS OF HELMINTHIC INFECTIONS BY THE SCHUEFFNER-LAARMAN METHOD.


THE TITRATION OF TOXOPLASMA-ANTIBODY.

THE TITRATION OF TOXOPLASMA-ANTIBODY.


VALIDATION OF 2 SPECIES OF COELOMOMYCES.


ANISAKIASIS.

ANISAKIASIS.


SOME REMARKS IN THE DEVELOPMENT AND THE TRANSMISSION OF RESISTANCE TO ANTIBIOTICS IN ENTEROBACTERIACEAE.


ON THE DISTRIBUTION OF INTESTINAL HELMINTHS IN THE URBAN AND BUSHLAND POPULATION IN SURINAM.


LEPTOSPIROSIS IN THE HIGHLANDS OF WEST NEW GUINEA. A SURVEY WITH PAPER-DRIED BLOOD SAMPLES.


EPIDEMIOLOGICAL EXPERIMENTS WITH SALMONELLA INFECTIONS IN MOUSE COLONIES.


THE DISINFECTION OF RAW VEGETABLES.

THE DISINFECTION OF RAW VEGETABLES.


BONE RESORPTION IN CASES WITH COMPLETE UPPER DENTURE. A QUANTITATIVE ROENTGENOGRAPHIC-PHOTOGRAMMETRIC STUDY.


IRRADIATION OF LYMPH NODES AND VESSELS. EXPERIMENTS IN RATS, WITH REFERENCE TO CANCER THERAPY.


CORONARY ANGIOGRAPHY. A TECHNICAL, ANATOMIC AND CLINICAL STUDY.


FOLLOW UP OF PATIENTS WITH CHRONIC DISCOID LUPUS ERYTHEMATOSUS.


THE HYDRODYNAMICS OF MICTURITION. EXAMINATION BY MEANS OF MICRO-MANOMETER AND UROFLOWMETER OF THE HYDRODYNAMIC CONDITIONS IN NORMAL SUBJECTS AND IN PATIENTS SUFFERING FROM OBSTRUCTION IN THE POSTERIOR PART OF THE URETHRA.


CLINICAL APPLICATION OF WHOLE BODY COUNTING OF 85SR AND 47CA IN PATIENTS WITH AND WITHOUT WIDESPREAD MALIGNANT SKELETAL DISEASE.


DERMANYSSUS GALLINAE (D. AVIUM) . STROPHULUS OR "INSECT" BITES. DIET OR D.D.T.


A FIFTH PHACOMATOSIS NAEVUS EPITHELIOMATODES MULTIPLEX.


OESOPHAGOSTOMIASIS IN MAN IN NORTH GHANA.


TINEA CAPITIS IN UGANDA.

TINEA CAPITIS IN UGANDA.


LYMPHATIC LEUKOSIS IN DOGS. AN EPIZOOTOLOGICAL, CLINICAL AND HAEMATOLOGICAL STUDY.


THE APPARENT SKIN COLOUR OF UNCONSCIOUS PATIENTS IN RELATION TO THE SOURCE OF ILLUMINATION.


A DEVICE FOR THE MEASUREMENT OF VENTILATION IN YOUNG CHILDREN UNDER GENERAL ANAESTHESIA.


ARTIFICIAL RESPIRATION AFTER CARDIAC SURGERY; SOME PHYSIOLOGICAL CONSIDERATIONS.


MECHANISMS OF ANAESTHETIC SLEEP.

MECHANISMS OF ANAESTHETIC SLEEP.


ANAESTHESIA WITH OBSTRUCTED AIRWAY; REMOVAL OF AN UNUSUAL FOREIGN BODY FROM THE LARYNGO-PHARYNX.


PHYSIOLOGICAL RESPONSES PRODUCED BY CHANGES IN ACID-BASE EQUILIBRIUM FOLLOWING PROFOUND HYPOTHERMIA.


CHLORPROPAMIDE OVERDOSE; AN EXERCISE IN INTENSIVE CARE.


SIMPLE UNITS FOR TESTING DEFIBRILLATORS.


ANAESTHESIA FOR CAROTID ENDARTERECTOMY USING LOCAL BRAIN PERFUSION AND COOLING.


POST-OPERATIVE VOMITING AFTER ETHER--AIR ANAESTHESIA.


THE MINISTRY OF HEALTH--THE NURSING DIVISION, ITS FUNCTION AND PERSONNEL.


THE NATIONAL HEALTH SERVICE.

THE NATIONAL HEALTH SERVICE.


PROFESSIONAL ORGANISATION--ITS PLACE IN THE LIFE OF A NURSE.


THE HOSPITAL--THE MATRON'S ROLE AND THE PATTERNS OF STAFFING.


NURSING EDUCATION.

NURSING EDUCATION.


THE NURSE--HER LEGAL POSITION AND PROTECTION.


PRESENT TRENDS IN BRITISH ACCIDENT SURGERY.


THE HISTORICAL DEVELOPMENT OF MODERN PSYCHIATRY IN BRITAIN AND GERMANY.


A CONTRIBUTION TO CANCER STATISTICS.

A CONTRIBUTION TO CANCER STATISTICS.


CARCINOMA-IN-SITU OF THE UTERINE CERVIX.


A CONTRIBUTION TO CLINICAL CANCER STATISTICS.


THE CURED GROUP IN SERIES OF PATIENTS TREATED FOR CANCER.


ENDOCRINE SURGERY FOR ADVANCED BREAST CANCER.


ENDOCRINE TREATMENT OF METASTASING BREAST CANCER.


A GENERAL REVIEW OF CHEMOTHERAPY OF CANCER.


RADIOTHERAPY OF CANCER.

RADIOTHERAPY OF CANCER.


CONTRIBUTION OF LOCAL ACTIVITY AND ELECTRIC SPREAD TO SOMATICALLY EVOKED POTENTIALS IN DIFFERENT AREAS OF THE HYPOTHALAMUS.


RELATIONSHIPS BETWEEN CEREBRAL AND MESODIENCEPHALIC NYSTAGMOGENIC CENTERS IN THE RABBIT.


RESEARCH ON THE STRUCTURE AND PHYSIOLOGY OF THE  EYES OF A LYCOSID SPIDER. 3. ELECTRORETINOGRAPHIC RESPONSES TO POLARIZED LIGHT.


INTERVAL ANALYSIS OF CELL DISCHARGE IN SPONTANEOUS AND OPTICALLY MODULATED ACTIVITY IN THE VISUAL SYSTEM.


BEHAVIOR AND REFLEXES OF CHRONIC THALAMIC CATS.


MODULATION OF THE RECURRENT DISCHARGE OF ALPHA MOTONEURONS IN DECEREBRATE AND SPINAL CATS.


ON THE ORIGIN OF THE DARK DISCHARGE OF RETINAL GANGLION CELLS.


AN ANALYSIS OF THE SUPRASPINAL INFLUENCES ACTING ON MOTONEURONS DURING SLEEP IN THE UNRESTRAINED CAT. MODIFICATION OF THE RECURRENT DISCHARGE OF THE ALPHA MOTONEURONS DURING SLEEP.


DISTRIBUTION OF ELECTRICAL RESPONSES TO SOMATIC STIMULI IN THE DIENCEPHALON OF THE CAT, WITH SPECIAL REFERENCE TO THE  HYPOTHALAMUS.


HEALTHY TEETH FOR HUDDERSFIELD.

HEALTHY TEETH FOR HUDDERSFIELD.


MICROELECTRODE RECORDING OF SLOW WAVE AND UNIT RESPONSES TO AFFERENT STIMULI IN THE HYPOTHALAMUS OF THE CAT.


INDUCTION MELTING OF COBALT-CHROMIUM ALLOYS; A COMPARISON WITH FLAME MELTING.


METAL SPRAYED MODELS FROM ELASTIC IMPRESSION MATERIALS; A PRELIMINARY STUDY.


SPONTANEOUS EXTRUSION OF A LARGE SUBMANDIBULAR CALCULUS.


AN INVESTIGATION INTO DENTAL UNDERGRADUATE EXAMINING TECHNIQUES.


INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES. Before their establishment as International Reference Preparations of Typhoid Vaccine, an acetone-inactivated vaccine (vaccine K) and a heat-phenol-inactivated vaccine (vaccine L) were tested on man in large-scale controlled field trials and simultaneously subjected to extensive collaborative laboratory studies on their relative potencies. Some 20 laboratories in 12 countries took part in these collaborative studies. This paper describes in detail the results of the investigation of 14 different assay procedures.One of the main objects of these studies was to determine whether one or more of the laboratory methods showed a correlation with the protective effectiveness of the vaccines against typhoid fever in man. It is clear from the results reported that none of the potency tests in animals reliably reflected the evidence obtained in human beings in the controlled field trials. Some of the assays, however, seem to offer promise of ability to distinguish between the potencies of typhoid vaccines in a manner reflecting their efficacy in man. Further research is needed before the value of these procedures can be definitely assessed.


STUDIES ON THE INFLUENCE OF THE ROUTE OF IMMUNIZATION IN THE ACTIVE MOUSE PROTECTION TEST WITH INTRAPERITONEAL CHALLENGE FOR POTENCY ASSAY OF TYPHOID VACCINES. In order to determine the reasons for the differences found in the potencies of typhoid vaccines in the course of active mouse protection tests when immunization was done subcutaneously or intraperitoneally and followed by intraperitoneal challenge, a series of experiments were conducted which have suggested that intraperitoneal immunization and challenge may be adversely or favourably influenced by the presence of undetermined substances in certain types of vaccine.Vaccines that prove least effective when administered intraperitoneally may affect the experimental animals in such a way that they do not respond optimally to the antigenic components of the vaccine, or some components of those vaccines may damage the peritoneum so that the animals are rendered more susceptible to the subsequent intraperitoneal challenge. On the other hand, it is possible that, where other vaccines show their greatest efficacy when administered intraperitoneally, this may be due to the presence of substances that enhance the vaccine's activity by inducing a non-specific local resistance in the peritoneum.The author suggests lines along which these questions may be investigated.


OBSERVATIONS ON THE TRANSMISSION OF SCHISTOSOMA HAEMATOBIUM AND SCHISTOSOMA BOVIS IN THE LAKE REGION OF TANGANYIKA. Previous investigations have shown that in the Lake Region of Sukumaland, Tanganyika, where Schistosoma haematobium is highly endemic, Bulinus (Physopsis) nasutus is responsible for the transmission of that schistosome in small, temporary rain pools. This area is one of low rainfall, and large artificial reservoirs are the chief source of water in the dry season. The role of these reservoirs in S. haematobium transmission was studied over a period of about a year.Previous work in South Africa had indicated the potential danger of bovine schistosomes to man. S. bovis is a very common parasite in cattle in the Lake Region, and a search for its intermediate host or hosts, previously unidentified, was therefore also made.The results of this double investigation suggest that large bodies of water are relatively unimportant in the transmission of both S. haematobium and S. bovis. Bulinus (Physopsis) africanus is shown to be a second intermediate of S. haematobium and a vector of S. bovis as well. Transmission of these parasites by this snail takes place principally in streams.


SOME MODIFICATIONS OF THE FLUORESCENT ANTIBODY TEST IN HUMAN BILHARZIASIS. Although the fluorescent antibody (FA) test for human bilharziasis described by Sadun and colleagues has proved of great value, its use involves certain difficulties which the author of the present paper has attempted to obviate. The first part of the paper describes a cheap and reproducible method for producing a cercarial antigen conjugated with rhodamine B 200 for use in the indirect FA test. The second part deals with a new modification in which the conjugated cercarial antigen is employed with a bentonite-absorbed FITC antihuman globulin serum and discusses the advantages of this test over the normal FA test.Experience has shown that the use of rhodamine-albumin-coated cercariae, conjugated cercariae or normal fixed cercariae as antigens does not always give valid results when compared with those obtained with the FA test or the ordinary complement-fixation test in bilharziasis. In the third part of this paper, however, the author describes a modification of the complement-fixation test involving the use of a bentonite-absorbed fluorescent antiguinea-pig serum and the RB 200 conjugated cercariae described earlier. This test has given reproducible results in known positive control human sera which have been valid when compared with the Sadun FA test, the conjugated cercarial FA test and the bentonite fluorescent antibody test described in the second part of this paper. In some instances the test results have also been supported by evidence from standard skin tests.


COMPARISON OF IMMUNE MECHANISMS IN VARIOUS EXPERIMENTAL MODELS OF CHOLERA. Two of the main features of human cholera-induction of diarrhoea and confinement of the infection to the lumen of the intestinal tract-may be reproduced in three experimental models: (a) the streptomycin-treated, starved guinea-pig; (b) the intestinal loop in the adult rabbit; and (c) the suckling rabbit. In this paper the author compares the two last-mentioned models with his earlier work in guinea-pigs.Intestinal antibody (coproantibody) was highly protective, while circulating antibody had little or no effect, in all three models. The protective coproantibody was specific for the heat-stable vibrio antigens. It did not affect the growth of vibrios in the intestine, and its function may possibly be regarded as antitoxic rather than antibacterial. Oral vaccination protected adult rabbits against challenge by the loop technique. Heat-killed vaccine was as effective in this respect as live vaccine.The author feels that the present uncertainty concerning the protective value of cholera vaccination may be due to the fact that conventional vaccine is designed to induce high serum titres only. He considers that since oral vaccine has been shown to induce and maintain the production of coproantibody in human volunteers, a field trial should be carried out to determine whether coproantibody is as protective in man as it has proved to be in the experimental models.


THE MAINTENANCE OF A LABORATORY COLONY OF GLOSSINA MORSITANS SINCE 1959. The authors present the results of the first successful attempt to rear a single-line colony of Glossina in the laboratory. Starting with 43 adults (21 males and 22 females) which emerged in the laboratory from G. morsitans pupae from Mozambique, this colony has been maintained under controlled environmental conditions at the Lisbon Institute of Tropical Medicine since 1959.Guinea-pigs are used as the sole food source, and are offered to the tsetse flies daily for six days each week.The colony kept developing (although not in constant progression) without the introduction of any new elements from September 1959 to September 1963. From that time, the pupae were kept in damp sand throughout the 24 hours during which they are formed. This technique led to highly encouraging progress in the growth of the population, the evolution curve of which coincides perfectly with that of an ideal population.


MERMITHID PARASITES OF BLACKFLIES.

MERMITHID PARASITES OF BLACKFLIES. Mermithid nematodes parasitize invertebrates only. A general account is given of their parasitism and the consequent mortality of blackflies. The author begins with a review of records of mermithid and blackfly association from different parts of the world and comments on the global distribution of the parasite. He discusses the life-histories of the parasites, stressing their adaptations to the moving environment of the aquatic stages of the blackfly and to the aerial environment of the adult. It is noted that the parasite usually kills its host upon emergence and has a restricted host range. Mermithids must be considered as selective mortality factors against blackfly populations. A survey of European and North American literature leads to conclusions concerning the role of the parasite in the natural regulation of blackflies. The possibility of utilizing these nematodes as biological control agents is discussed.


CRESYL BLUE AND CRESYL BLUE PLUS SUDAN 3 AS STAINS FOR USE IN EXFOLIATIVE AND OTHER CYTOLOGY. Investigating the value of a number of supravital strains for use in exfoliative cytology, the authors found cresyl blue (1% solution in distilled water), with and without Sudan III (0.3% in 70% alcohol), to be reliable and relatively long-lasting. Specimens stained with cresyl blue and Sudan III can be kept for one or two days, or for longer periods (up to 3 weeks or more) if a moist chamber is used containing filter-paper moistened with 10% formol to prevent fungal contamination. These stains are less toxic than Janus green and simpler to use than neutral red. The minimum of simple laboratory apparatus is needed.During 1960-62, 1955 specimens from 460 hospitalized patients in Beer-Yaacov, Israel, were stained with these two preparations. Cytological examination led to a diagnosis of cancer in 16% of the patients, with only 9 false diagnoses.


NOMENCLATURE OF HAEMOGLOBINS.

NOMENCLATURE OF HAEMOGLOBINS.


IRVING HEWARD CAMERON (1855-1933), PROFESSOR OF SURGERY, UNIVERSITY OF TORONTO, 1897-1920.


PERCUTANEOUS TRANSHEPATIC CHOLANGIOGRAPHY.


TIBIAL PLATEAU FRACTURES.

TIBIAL PLATEAU FRACTURES.


GASTRIC COOLING AND HEPATIC FUNCTION.

GASTRIC COOLING AND HEPATIC FUNCTION.


THE OBSTRUCTIVE FACTOR IN URETHRAL DIVERTICULUM IN THE PARAPLEGIC PATIENT.


THERMAL BURN ENCEPHALOPATHY.

THERMAL BURN ENCEPHALOPATHY.


SURGERY OF INTRACRANIAL BERRY ANEURYSMS: A REVIEW.


STOMACH DUPLICATION.

STOMACH DUPLICATION.


ACUTE ALCOHOLIC POISONING: A COMPLICATION OF GASTRIC HYPOTHERMIA.


RUPTURE OF THE INTERVENTRICULAR SEPTUM DUE TO BLUNT TRAUMA.


FAT EMBOLISM: ITS PRODUCTION AND SOURCE OF FAT.


EXPERIMENTAL STUDIES ON FIBROSIS OF THE SPHINCTER OF ODDI AND ON SPHINCTEROTOMY.


EXPERIMENTAL RECONSTRUCTION OF THE CERVICAL ESOPHAGUS WITH A FREE ENTERIC GRAFT.


ROBERT MEREDITH JANES: SCHOLAR, TEACHER, EDITOR AND SURGEON.


MICRODETERMINATION OF PROLINE IN SERUM.

MICRODETERMINATION OF PROLINE IN SERUM.


ESTIMATION OF URINARY 5-HYDROXYINDOLEACETIC ACID BY PAPER CHROMATOGRAPHY--A SENSITIVE METHOD.


POLAROGRAPHIC DETERMINATION OF TRACES OF GOLD IN BLOOD AND SERUM.


DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ALBUMIN IN HUMAN SERUM.


SEPARATION AND DETERMINATION OF THE TOTAL GLOBULINS OF HUMAN SERUM.


EVALUATION OF A MODIFICATION OF THE ZAK-KILIANI REACTION FOR DETERMINATION OF SERUM CHOLESTEROL.


CLOSED-SYSTEM APPARATUS FOR AERATION-DIFFUSION: APPLICATION TO DETERMINATION OF BLOOD AMMONIA.


A NEW INDICATOR FOR THE CHELOMETRIC MEASUREMENT OF CALCIUM IN SERUM AND URINE.


IMMUNOGLOBULIN COMPONENTS OF "GAMMA" GLOBULIN IN HUMAN SERUM.


AN IMPROVED COLORIMETRIC TRANSAMINASE ASSAY.


ALTERATIONS OF AMMONIA METABOLISM IN THE CEREBRAL CORTEX OF RATS WITH HEPATIC DAMAGE INDUCED BY CARBON TETRACHLORIDE.


CHANGES IN ENZYME ACTIVITY, RELATED TO D-GLUCARIC ACID SYNTHESIS, WITH AGE, PREGNANCY AND MALIGNANCY.


INTRACELLULAR HYDROGEN ION CONCENTRATION IN RENAL ACIDOSIS.


THE VENTILATORY RESPONSE TO CARBON DIOXIDE AND  HYDROGEN ION IN RENAL FAILURE.


THE UTILIZATION OF INTRAVENOUSLY ADMINISTERED GLUCOSE IN TROPICAL SPRUE.


THE CIRCULATORY EFFECTS OF PHENTOLAMINE IN MAN WITH PARTICULAR RESPECT TO CHANGES IN FOREARM BLOOD FLOW.


URINARY EXCRETION OF HYDROGEN ION IN PATIENTS WITH URIC ACID CALCULI.


IN VIVO DIALYSIS OF FAECES AS A METHOD OF STOOL ANALYSIS. I. TECHNIQUE AND RESULTS IN NORMAL SUBJECTS.


THE METABOLISM OF GLYCEROL AND FREE FATTY ACIDS DURING EXERCISE IN PATIENTS WITH RHEUMATIC HEART DISEASE.


STUDIES ON HISTIDINE AND UROCANATE METABOLISM IN PREGNANCY.


THE MINIMUM CRITICAL CLOSING PRESSURE OF DIGITAL BLOOD VESSELS IN HYPERTENSION.


CROWN AND BRIDGEWORK OR "I BELIEVE". 3.

CROWN AND BRIDGEWORK OR "I BELIEVE". 3.


BROOKLANDS  COUNTY TECHNICAL COLLEGE DENTAL LABORATORIES..


HISTOLOGIC STUDY OF THE TATTOO MARK.

HISTOLOGIC STUDY OF THE TATTOO MARK.


CHROMOBLASTOMYCOSIS.

CHROMOBLASTOMYCOSIS.


ORAL AMPHOTERICIN B IN THE MANAGEMENT OF CUTANEOUS AND MUCOSAL CANDIDIASIS.


TOLNAFTATE IN DERMATOLOGY: A NEW, POTENT TOPICAL FUNGICIDE.


FORMATION OF HISTIOCYTES BY THE OMENTUM IN VITRO.


X-IRRADIATION-INDUCED POLYPLOIDY IN HUMAN LEUCOCYTE CULTURES.


SEXUAL DIFFERENCE IN RAT LIVER MICROSOMAL CYTOCHROME B5.


PATTERNS OF CUTANEOUS PIGMENTATION FOLLOWING SUNLIGHT IRRADIATION.


LACTOSURIA AND LACTASE DEFICIENCY IN ADULT CELIAC DISEASE.


AN ULTRASTRUCTURAL STUDY OF THE "EXTRANEOUS COAT" OF HUMAN COLONIC MUCOSA.


PRESSURE AND POTENTIAL DIFFERENCE CHARACTERISTICS OF SURGICALLY CREATED CANINE HIATAL HERNIA.


CHRONIC DUODENAL ULCERS IN PANTOTHENATE DEFICIENT MICE.


CELL REPLICATION IN THE GASTROINTESTINAL TRACT OF MAN.


AGANGLIONOSIS OF THE ENTIRE COLON IN AN ADOLESCENT.


ULCERATION OF THE COMMON BILE DUCT AS A CAUSE OF HEMOBILIA.


ISOENZYMES OF SERUM AMYLASE IN MAN.

ISOENZYMES OF SERUM AMYLASE IN MAN.


THE RADIOLOGY OF MASTOID DISEASE IN INFANTS AND CHILDREN,.


EFFECT OF FILTRATION IN DIAGNOSTIC RADIOLOGY.


RESPONSE TO METHOPYRAPONE (SU-4885) AND PYROGEN TEST IN IDIOPATHIC HYPOPITUITARY DWARFISM.


URINARY EXCRETION OF PARATHYROID HORMONE IN MAN: EFFECTS OF CALCIUM LOADS, PROTEIN-FREE DIETS, ADRENAL CORTICAL STEROIDS AND NEOPLASTIC DISEASE.


EFFECT OF EPINEPHRINE ON RADIOIODIDE UPTAKE BY THE NORMAL HUMAN THYROID.


ANTAGONISM BETWEEN PARATHYROID EXTRACT AND ADRENAL CORTICAL STEROIDS IN MAN.


SUPPRESSION OF TESTOSTERONE PRODUCTION BY PHYSIOLOGIC DOSES OF 2-ALPHA-METHYLDIHYDROTESTOSTERONE PROPIONATE.


ANTAGONISM BY CORTISONE OF THE LINEAR GROWTH INDUCED IN HYPOPITUITARY PATIENTS AND HYPOPHYSECTOMIZED RATS BY HUMAN GROWTH HORMONE.


FLUORIMETRIC DETERMINATION OF TOTAL ESTROGENS AFTER GEL FILTRATION OF ENZYMATICALLY HYDROLYZED URINE.


HYPERTHYROIDISM IN A PATIENT WITH A PITUITARY CHROMOPHOBE ADENOMA.


PLASMA LEVEL OF CORTEXOLONE AS A FUNCTION OF THE ADRENAL CORTEXOLONE PRODUCTION RATE.


LIPOLYTIC EFFECTS OF HUMAN GROWTH HORMONE IN RESISTANT OBESITY.


ANDROGEN SYNTHESIS BY TESTICULAR TISSUE FROM A PATIENT WITH GONADAL INSUFFICIENCY.


THYROID RESPONSE TO HUMAN THYROTROPIN IN MAN.


PLASMA CONCENTRATION AND BIOSYNTHESIS OF TESTOSTERONE IN THE SYNDROME OF FEMINIZING TESTES.


STUDIES OF THE DISTRIBUTION OF IODINE AND PROTEIN IN A STRUMA OVARII.


EVALUATION OF IODINE/CREATININE RATIOS OF CASUAL SAMPLES AS INDICES OF DAILY URINARY IODINE OUTPUT DURING FIELD STUDIES.


USE OF METHOPYRAPONE (SU-4885) IN THE STUDY OF PITUITARY-ADRENAL RESPONSE IN PATIENTS UNDER CORTICOSTEROID TREATMENT.


LACK OF CORRELATION BETWEEN URINARY IODINE AND DIETARY IODINE IN GOITROUS CHILDREN.


HUMAN GROWTH HORMONE CONTENT OF PITUITARIES FROM EMBALMED BODIES.


EFFECTS OF THE THERAPIST AND THE PATIENT ON EACH OTHER'S THERAPEUTIC BEHAVIOR.


EFFECT OF BRIEF PUPPET THERAPY UPON THE EMOTIONAL RESPONSES OF CHILDREN UNDERGOING CARDIAC CATHETERIZATION.


A CHILDREN'S SOCIAL DESIRABILITY QUESTIONNAIRE.


METHODOLOGICAL CONSIDERATIONS IN THE ASSESSMENT OF  ACQUIESCENCE IN THE MA AND SD SCALE.


PROJECTION OF HOSTILITY ON THE TAT AS A FUNCTION OF STIMULUS, BACKGROUND, AND PERSONALITY VARIABLES.


VALUES AND THE USE OF TESTS.

VALUES AND THE USE OF TESTS.


PERSONALITY CONFLICT, ORIGINALITY OF RESPONSE, AND RECALL.


STRUCTURE OF CLIENT ATTITUDES TOWARD COUNSELING AND THEIR RELATION TO CLIENT-COUNSELOR SIMILARITY.


FURTHER DATA CONCERNING THE DIMENSIONALITY OF RATINGS OF THE THERAPIST'S VERBAL EXPLORATORY BEHAVIOR.


VISUAL IMAGERY CORRELATED TO A MEASURE OF CREATIVITY.


DYNAMIC AND BEHAVIORAL PREDICTORS OF HYPNOTIZABILITY.


ANXIETY AND INTELLECTUAL PERFORMANCE: A PARTIAL FAILURE TO REPLICATE.


CONFORMITY AND BRAIN DAMAGE.

CONFORMITY AND BRAIN DAMAGE.


THE BENDER-GESTALT AS A PREDICTIVE AND DIAGNOSTIC TEST OF READING PERFORMANCE.


THE REPRESSION-SENSITIZATION DIMENSION IN RELATION TO ANXIETY RESPONSES.


PREVALENCES OF RELIGIOUS GROUPS IN CHILD-GUIDANCE CLINICS: SUPPLEMENTARY DATA.


A FACTOR-ANALYTIC APPROACH TO OBJECT-SORTING BEHAVIOR.


RELATIONSHIP BETWEEN MMPI VARIABLES AND  PERCENTAGE AND AMPLITUDE OF EEG ALPHA ACTIVITY.


MMPI PROFILES OF THREE OBESITY SUBGROUPS.


AN ABBREVIATED FORM OF THE WECHSLER INTELLIGENCE SCALE FOR CHILDREN.


PREDICTING THE POSTHOSPITAL WORK ADJUSTMENT OF MARRIED, MALE SCHIZOPHRENICS.


NOMENCLATURE OF THE PROTEINS OF COW'S MILK--SECOND REVISION. REPORT OF THE COMMITTEE ON MILK PROTEIN NOMENCLATURE, CLASSIFICATION, AND METHODOLOGY OF THE MANUFACTURING SECTION OF ADSA FOR 1963-64.


OVERINCLUSION AND CONCRETENESS AMONG PATHOLOGICAL GROUPS.


NEW METHOD FOR EXTRACTION OF MILK PHOSPHOLIPIDS.


SOME OF THE FORCED CONVECTION HEAT TRANSFER CHARACTERISTICS OF CONDENSED MILKS.


GELATION OF MILK SOLIDS BY ORTHOPHOSPHATE.


EFFECT OF DENATURING AGENTS OF STABILITY OF CASEIN, MILK, AND STERILE CONCENTRATED MILK.


COMPARISON OF METHODS FOR ESTIMATING MILK SOMATIC CELLS.


FACTORS AFFECTING IODINE CONCENTRATION IN BOVINE MILK.


FEEDING VALUE OF DWARF CORN SILAGE COMPARED WITH CORN AND HYBRID SORGHUM SILAGES.


COMPARISON OF FEEDING VALUE OF ALFALFA HAY, SILAGE, AND LOW-MOISTURE SILAGE.


NITRATE TOXICITY IN DAIRY HEIFERS. 3. ENDOCRINE RESPONSES TO NITRATE INGESTION DURING PREGNANCY.


REPRODUCTIVE AND PHYSIOLOGICAL RESPONSES OF HOLSTEIN HEIFERS TO CONTROLLED AND NATURAL CLIMATIC CONDITIONS.


INFLUENCE OF CALCIUM CONCENTRATION IN MILK UPON COOKED FLAVOR DEVELOPMENT.


RESPONSE OF YOUNG HOLSTEIN-FRIESIAN HEIFERS TO PHENOTHIAZINE AND DIETHYLSTILBESTROL.


QUANTITATIVE ANALYSIS OF THE MAJOR FREE FATTY ACIDS IN BLUE CHEESE.


METHOD FOR DETERMINING TOTAL VOLATILE BASES IN RUMEN FLUID BY STEAM DISTILLATION.


METHOHEXITAL SODIUM, BREVANCE, ANESTHESIA FOR CALVES AND SHEEP.


RHYTHMIC CONTRACTIONS OF THE TEAT SPHINCTER IN THE BOVINE.


SOME PROPERTIES OF INSTANTIZED DRY MILKS.


EXISTENTIAL ANALYSIS AND PASTORAL COUNSELING.


WILLIAM JAMES AND EXISTENTIAL AUTHENTICITY.


A COMMENTARY ON THE PROBLEM OF HUMAN IDENTITY.


THE SARTREAN TYPOLOGY: THOSE WHO DENY FREEDOM AND THOSE WHO IGNORE IT.


SOCIAL ACTION: AN EXISTENTIAL APPROACH.

SOCIAL ACTION: AN EXISTENTIAL APPROACH.


DIRECTION FOR PSYCHOTHERAPY.

DIRECTION FOR PSYCHOTHERAPY.


EXISTENTIAL AND PHENOMENOLOGICAL FRONTIERS: EMERGENT CHARACTERISTICS OF MASS SOCIETY AND MASS CULTURE.


CORRECTION OF MANDIBULAR PROGNATHISM BY OPEN, OBLIQUE SLIDING OSTEOTOMIES OF THE RAMI.


SPINAL PREPARATIONS AND SPINAL SHOCK.

SPINAL PREPARATIONS AND SPINAL SHOCK.


CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF "BRAHMI".


EXTRAORAL TRACTION WITH HALO HEAD FRAME FOR COMPLEX FACIAL FRACTURES.


PAPILLARY CYSTADENOMA LYMPHOMATOSUM, A DEVELOPMENTAL MALFORMATION: HISTOCHEMICAL EVIDENCE.


BONE-TOOTH AUTOGRAFTS.

BONE-TOOTH AUTOGRAFTS.


EFFECTS OF PREMEDICATION ON VENTILATION AS MEASURED BY CLOSED-CIRCUIT SPIROMETRY.


BILATERAL SUBCONDYLAR OSTEOTOMY: REPORT OF CASE.


TRAUMATIC MYOSITIS OSSIFICANS OF THE MASSETER MUSCLE: REPORT OF CASE.


RELATIONSHIP OF THE DENTIGEROUS CYST AND THE AMELOBLASTOMA: REPORT OF CASE.


EFFECT OF URARIA PICTA ON FRACTURE HEALING: TENSILE STRENGTH AND STRONTIUM 85 UPTAKE STUDIES.


OSTEOGENIC SARCOMA INVOLVING THE MANDIBLE: REPORT OF CASE.


UNILATERAL HYPERPLASIA OF ANGLE OF MANDIBLE: REPORT OF CASE.


STUDY OF INTESTINAL JUICE WITH REFERENCE TO GONADS.


AUTOGENOUS BONE TO REPAIR MANDIBULAR CYST DEFECTS: REPORT OF TWO CASES.


ROLE OF GONADAL HORMONES IN ATROPHY OF SUPRARENAL GLANDS INDUCED BY CORTICOIDS.


A STUDY OF KIDNEY TRANSPLANTATION IN DOGS.


UNUSUAL ZYGOMATIC CYST: REPORT OF CASE.

UNUSUAL ZYGOMATIC CYST: REPORT OF CASE.


LUDWIG'S ANGINA: REPORT OF TWO CASES.

LUDWIG'S ANGINA: REPORT OF TWO CASES.


ERYTHROCYTIC CHANGES AFTER SPLENECTOMY IN DOGS.


EFFECT OF SOME ANTIHISTAMINIC AGENTS ON INTESTINAL SECRETION OF DOGS.


A COMPARISON OF BONE RESORPTION FOLLOWING INTRASEPTAL ALVEOLOTOMY AND LABIAL ALVEOLECTOMY.


THE DYNAMIC NATURE OF THE LOWER DENTURE SPACE.


A HISTOLOGIC COMPARISON OF THE EDENTULOUS DENTURE AND NON-DENTURE BEARING TISSUES.


THE INFLUENCE OF OCCLUSAL CONTACT AREA ON CHEWING PERFORMANCE.


THE EFFECT OF DENTURE FACTORS ON MASTICATORY PERFORMANCE. 3. THE LOCATION OF THE FOOD PLATFORMS.


INFLUENCE OF IMPRESSION PROCEDURES AND OCCLUSAL LOADING ON PARTIAL DENTURE MOVEMENT.


THE QUALITY OF UNION FORMED IN CASTING GOLD TO EMBEDDED ATTACHMENT METALS.


REPRODUCTION OF FUNCTIONAL TOOTH FORM IN FULL CAST CROWNS.


REPLACEMENT OF THE AORTIC VALVE WITH INDIVIDUAL TEFLON LEAFLETS.


COMPLICATIONS OF STARR-EDWARDS MITRAL VALVE REPLACEMENT.


TWO ONE-STAGE IMPRESSION TECHNIQUES FOR FIXED PROSTHESES.


THE USE OF PINS IN RESTORATIVE DENTISTRY. I. PARALLEL PIN RETENTION OBTAINED WITHOUT USING PARALLELING DEVICES.


INTERCHANGEABLE FACINGS AND PORCELAIN DENTURE BASES FOR ANTERIOR FIXED PARTIAL DENTURES.


SUBCOSTAL, TRANSDIAPHRAGMATIC INSERTION OF A CARDIAC PACEMAKER.


AN APPRAISAL OF THE SURGICAL MANAGEMENT OF HEART BLOCK. CLINICAL EXPERIENCES WITH 33 PATIENTS.


OBSERVATION OF ELECTROMAGNETIC SIGNALS FROM IMPLANTABLE PACEMAKERS.


REHABILITATION RATIONALE FOR PULPLESS TEETH.


MAXILLOFACIAL PROSTHETICS: EVOLUTION AND PRACTICAL APPLICATION IN PATIENT REHABILITATION.


ASYMMETRIC EXAGGERATED MITRAL ANNULOPLASTY: REPAIR OF MITRAL INSUFFICIENCY WITH HEMODYNAMIC PREDICTABILITY.


IMPORTANCE OF AXIAL INCLINATIONS OF TEETH IN ATTAINMENT OF PARALLELISM.


FAILURE OF GLUCOSE-INSULIN-POTASSIUM INFUSION TO MODIFY THE CONSEQUENCES OF ACUTE CORONARY ARTERY LIGATION.


MAXILLOFACIAL PROSTHETICS DEPARTMENTS IN DENTAL SCHOOLS AND MEDICAL CENTERS.


CONCERNING THE GLOSSARY OF THE AMERICAN EQUILIBRATION SOCIETY.


CORONARY ARTERY DISSECTION: A COMPLICATION OF CANNULATION.


THE EUSTACHIAN TUBE, THE JAW JOINT, AND HEARING.


MORE EFFECTIVE PALLIATION OF TRANSPOSITION OF THE GREAT VESSELS.


THE PATHOGENESIS OF ANGIOGRAPHIC NONVISUALIZATION OR ATTENUATION OF A PATENT PULMONARY ARTERY AND THE ROLE OF BRONCHIAL ARTERY-PULMONARY ARTERY ANASTOMOSIS.


DENTISTS CAN WRITE PRESCRIPTIONS.

DENTISTS CAN WRITE PRESCRIPTIONS.


SURGICAL TREATMENT OF PULMONIC STENOSIS WITH INTACT VENTRICULAR SEPTUM WITH THE USE OF CARDIOPULMONARY BYPASS. REPORT OF 26 CASES AND A REVIEW OF THE LITERATURE.


A DISPOSABLE DENTAL FACE MASK WITH A PLASTIC EYE SHIELD FOR OPERATING WITH THE AIR TURBINE DRILL.


FLOW CHARACTERISTICS OF THE MENISCUS PROSTHETIC HEART VALVE.


EXPERIMENTAL GRAFTS OF THE SUPERIOR VENA CAVA WITH TEMPORARY ARTERIOVENOUS SHUNTS.


THE CHALLENGE OF SUPERIOR VENA CAVAL OBSTRUCTION.


REVERSAL OF PULMONARY BLOOD FLOW IN THE DOG.


MASSIVE PULMONARY COLLAPSE DURING OPEN-HEART SURGERY.


THE EFFECT OF INTRALOBAR PULMONARY SEQUESTRATION ON CARDIAC OUTPUT.


HYDATID CYST OF THE LEFT VENTRICLE OF THE HEART: MITRAL INSUFFICIENCY AFTER SURGICAL TREATMENT.


SOLITARY AMYLOID TUMOR OF THE LUNG. A CASE REPORT.


SUCCESSFUL SURGICAL MANAGEMENT OF THROUGH-AND-THROUGH GUNSHOT WOUND OF THE HEART. A CASE REPORT.


SUCCESSFUL TREATMENT OF POSTOPERATIVE ATELECTASIS BY INTRAVENOUS INJECTION OF AMINOPHYLLINE. REPORT OF 4 CASES.


A SIMPLE OPERATION FOR THE PALLIATIVE TREATMENT OF TRACHEOESOPHAGEAL FISTULA DUE TO CANCER.


METASTATIC CARCINOMA TO THE TRACHEA: REPORT OF A CASE OF PALLIATION BY RESECTION AND MARLEX GRAFT.


THE VALUE OF PREOPERATIVE BRONCHOGRAPHY IN RESECTION OF THE LEFT UPPER LOBE OF THE LUNG.


AN EXPERIMENTAL CYANOTIC CARDIOVASCULAR DISEASE MODEL.


PROBLEMS IN THE DIAGNOSIS OF INTESTINAL AMOEBIASIS.


PLEURISY AS A PRESENTING FEATURE OF HEPATIC AMOEBIASIS.


ENTAMIDE FUROATE IN THE TREATMENT OF INTESTINAL AMOEBIASIS.


EXPERIMENTAL ANCYLOSTOMA DUODENALE INFECTION IN DOGS.


CORONARY ATHEROSCLEROSIS AND CORONARY HEART DISEASE IN CEYLON.


CONSIDERATIONS ON THE HAEMATOLOGICAL PICTURE OF MALNOURISHED CHILDREN.


THE NUTRITIVE VALUE OF THE DIETS OF HONG KONG CHILDREN.


CHILDHOOD ANAEMIA IN THE TROPICS.

CHILDHOOD ANAEMIA IN THE TROPICS.


A PATTERN OF WEIGHT GAIN IN GAMBIAN BABIES DURING THE FIRST 18 MONTHS OF LIFE.


PERSPECTIVES IN DERMATOPATHOLOGY.

PERSPECTIVES IN DERMATOPATHOLOGY.


PHOTOSENSITIVITY ASSOCIATED WITH DISORDERS OF PORPHYRIN METABOLISM.


DISEASES CAUSED OR AGGRAVATED BY SUNLIGHT.


DYSFUNCTION OF HAIR GROWTH.

DYSFUNCTION OF HAIR GROWTH.


DIABETES AND DISEASES OF THE SKIN.

DIABETES AND DISEASES OF THE SKIN.


DYSLIPIDOSES.

DYSLIPIDOSES.


CUTANEOUS REACTIONS TO INTERNAL MALIGNANCY.


GENODERMATOSES.

GENODERMATOSES.


CUTANEOUS REACTIONS TO DRUGS: WITH PARTICULAR REFERENCE TO PENICILLIN SENSITIVITY.


PRESENT STATUS OF SUPERFICIAL FUNGUS INFECTIONS OF THE SKIN, HAIR AND NAILS.


ACNE VULGARIS.

ACNE VULGARIS.


PSORIASIS.

PSORIASIS.


CUTANEOUS VASCULITIS.

CUTANEOUS VASCULITIS.


AUTOIMMUNITY AND CUTANEOUS DISEASE.

AUTOIMMUNITY AND CUTANEOUS DISEASE.


SARCOIDOSIS.

SARCOIDOSIS.


DIAGNOSIS AND TREATMENT OF LEPROSY IN THE UNITED STATES.


TRENDS IN THE DIAGNOSIS AND TREATMENT OF SYPHILIS.


THE TREATMENT OF TRIGEMINAL NEURALGIA: A CLINICAL TRIAL OF CARBAMAZEPINE ("TEGRETOL").


THE SPREAD OF NEOMYCIN-RESISTANT STAPHYLOCOCCI IN A HOSPITAL.


THE RELATIONSHIP BETWEEN RESPONSE TO TREATMENT AND THE CLASSIFICATION OF MENTAL ILLNESS.


SMALLPOX: AN ANACHRONISM.

SMALLPOX: AN ANACHRONISM.


CARDIAC ARREST IN BRONCHIAL ASTHMA.

CARDIAC ARREST IN BRONCHIAL ASTHMA.


A GREATLY IMPROVED WAY OF DISTRICT NURSING.


THE SURGEON'S CHANGING ROLE IN MEDICAL EDUCATION.


NATIONAL POISONS INFORMATION SERVICE.

NATIONAL POISONS INFORMATION SERVICE.


THE BIOLOGICAL TESTING OF MILK. A REPORT BY THE STAFF COMMITTEE OF THE PUBLIC HEALTH LABORATORY SERVICE.


HAND, FOOT AND MOUTH DISEASE, 1963-64. A STUDY OF CASES AND FAMILY CONTACTS.


STUDIES ON INFLUENZA IN SOFIA, 1962.

STUDIES ON INFLUENZA IN SOFIA, 1962.


OUR EXPERIENCE WITH SCHEIE'S FILTERING BASAL IRIDECTOMY IN VARIOUS FORMS AND STAGES OF GLAUCOMA.


STUDIES ON THE INCIDENCE AND FORMS OF TUBERCULOSIS IN THE AGE GROUP ABOVE 22 YEARS, ACCORDING TO POST-MORTEM MATERIAL FOR THE PERIOD 1940-1959.


CANCER OF THE LARYNX (CLINICAL AND PATHOLOGIC SURVEY).


DYNAMIC FOLLOW UP STUDY OF SOME ALLERGIC AND IMMUNOLOGIC INDICES IN THE PATHOGENETIC TREATMENT OF EXPERIMENTAL MYOCARDITIS AND ARTHRITIS.


ELECTROPHORETIC STUDIES ON PROTEIN FRACTIONS IN SERA OF DOGS, INFECTED WITH ECHINOCOCCUS.


ABOUT THE UNSOLVED PROBLEMS OF THE SUBPERIOSTEAL IMPLANTATIONS.


ABOUT THE TRAUMATIC INJURIES OF THE TEETH AND THE PERIDENTAL TISSUES.


A DIFFERENTIAL DIAGNOSTIC TEST FOR THE CENTRAL TUMOURS OF THE JAWS.


THE GLUCOCORTICOID INFLUENCE UPON THE CONDITION OF THE PERIDENTAL MEMBRANE.


GUARANTEE STERILITY.

GUARANTEE STERILITY.


PROSPECTS IN PRENATAL PHYSIOLOGY, DIAGNOSIS, AND TREATMENT.


THE BI-DIRECTIONAL PLACENTAL TRANSFER OF I131 3:5:3' TRIIODOTHYRONINE IN THE RHESUS MONKEY.


MATERNAL, CORD, AND SERIAL VENOUS BLOOD: PROTEIN-BOUND IODINE, THYROID-BINDING GLOBULIN, THYROID-BINDING ALBUMIN, AND PREALBUMIN VALUES IN PREMATURE INFANTS.


SYMPTOMATIC HYPOGLYCEMIA, VISCERAL FATTY METAMORPHOSIS, AND AGLYCOGENOSIS IN AN INFANT LACKING GLYCOGEN SYNTHETASE AND PHOSPHORYLAS.


THE PROGNOSTIC VALUE OF THE ELECTROENCEPHALOGRAM IN NEONATAL CONVULSIONS.


HEMOPHILUS INFLUENZAE MENINGITIS IN A PREMATURE INFANT.


PILONIDAL SINUS IN INFANCY.

PILONIDAL SINUS IN INFANCY.


IATROGENIC HYPOPHOSPHAEMIA IN INFANTS WITH RENAL INSUFFICIENCY.


AMNIOTIC FLUID SPECTROPHOTOMETRY AND EARLY DELIVERY IN THE MANAGEMENT OF ERYTHROBLASTOSIS FETALIS.


THE USE OF AMNIOCENTESIS AND FETAL TRANSFUSION IN ERYTHROBLASTOSIS FETALIS.


PRENATAL TREATMENT OF ERYTHROBLASTOSIS FETALIS FOLLOWING HYSTEROTOMY.


FAMILY EPIDEMIOLOGY. REPORT OF A SYMPOSIUM.


LETTER TO THE EDITOR. HEMANGIOMAS, HEPATIC INVOLVEMENT, CONGESTIVE FAILURE.


HISTORY OF CANCER QUACKERY.

HISTORY OF CANCER QUACKERY.


SOME FACTS AND FANCIES ABOUT CANCER.

SOME FACTS AND FANCIES ABOUT CANCER.


SIGNIFICANT SEGMENTS OF THE HERRICK-YERKES CORRESPONDENCE RELATIVE TO PSYCHOBIOLOGY AND THEIR PERSONAL PHILOSOPHIES.


MECHANISMS OF OXIDATIVE PHOSPHORYLATION--OBSERVATIONS AND SPECULATION.


AESTHETICS AND THE BIOLOGY OF THE FLEETING MOMENT.


HASH.

HASH.


WHY IS THE MEDICAL PROGESSION ESTIMABLE IN THE INDIVIDUAL BUT NOT IN THE GENERALITY?


THE USE OF THE FISH IN NEUROPSYCHOLOGY.

THE USE OF THE FISH IN NEUROPSYCHOLOGY.


PURIFICATION AND PARTIAL CHARACTERIZATION OF MOUSE HEMOPEXIN (BETA 2-3 GLOBULIN).


SENSITIVITY OF BLUETONGUE VIRUS TO ETHER AND SODIUM DEOXYCHOLATE.


PROTECTION AGAINST CARDIOVASCULAR COLLAPSE IN ACUTE ADRENALECTOMY BY AUTONOMIC BLOCKING AGENTS.


EFFECTS OF ENDOTOXINS ON CULTURED LEUKOCYTES.


EFFECT OF FUDR ON INTERFERON PRODUCTION.


ISOGENEIC MARROW INFUSION FOLLOWING NITROGEN MUSTARD IN THE DOG.


EFFECT OF SODIUM TAUROCHOLATE ON FAT MALABSORPTION INDUCED BY FEEDING UNHEATED SOYBEAN PROTEINS.


PHOSPHORUS IN CELL FRACTIONS OF SKELETAL MUSCLE FROM MICE WITH HEREDITARY MUSCULAR DYSTROPHY.


ALKALINE PHOSPHATASE ACTIVITY OF L-M MOUSE CELLS AND VARIANTS.


TIME RELATIONSHIP OF INJECTION OF ACTINOMYCIN D AND ANTIGEN TO THE IMMUNE RESPONSE.


LONG TERM CULTURE OF THYMIC CELLS FROM NEWBORN MOUSE THYMUS FRAGMENTS.


EFFECT OF SIALIDASE ANTISERUM ON TOXICITY OF INFLUENZA VIRUS.


EFFECTS OF TRYPSIN ON ULTRAVIOLET IRRADIATED-MYOSIN A.


PLASMA LIPID VARIATIONS AND FATTY ACID COMPOSITION IN NORMAL MALE AND FEMALE ADULT RABBITS.


RADIOACTIVE DISTRIBUTION OF TRITIUM LABELED ACETOPHENONE DERIVATIVE OF 16-ALPHA, 17-ALPHA-DIHYDROXYPROGESTERONE.


DEVELOPMENT AND CHARACTERISTICS OF THE RABBIT KIDNEY CELL STRAIN, LLC-RK.


TRANSAMINASES IN BLOOD, URINE AND CEREBROSPINAL FLUID OF NORMAL AND UNILATERALLY NEPHRECTOMIZED DOGS.


PROTECTION INDUCED BY BACTERIAL ENDOTOXIN AGAINST WHOLE-BODY X-IRRADIATION IN GERMFREE AND CONVENTIONAL MICE.


PLAQUE STUDIES WITH CERTAIN GROUP B ARBOVIRUSES. 3. ST. LOUIS VIRUS ON CHICK EMBRYO TISSUE CULTURE.


SIGNIFICANCE OF ANTIBODY TO MYCOPLASMA HOMINIS TYPE 1 AS MEASURED BY INDIRECT HEMAGGLUTINATION.


SOLUBILIZATION BY BUTANOL OF RABBIT CELL-ANTIGENS ASSOCIATED WITH THE REJECTION OF TRANSFERRED LYMPH NODE CELLS.


BETA-HYDROXYACYL DEHYDROGENASE IN HUMAN ARTERIAL TISSUE.


A COMPARISON OF FATTY ACID SYNTHESIS BY LIVER AND KIDNEY.


SEQUESTRATION OF SERUM LOW-DENSITY LIPOPROTEINS IN THE ARTERIAL INTIMA BY COMPLEX FORMATION.


ENHANCEMENT BY PARATHYROIDECTOMY OF GLYCOPROTEIN MOBILIZING PROPERTY OF PARATHYROID EXTRACT.


GROWTH AND GLYCOLYSIS IN THE HUMAN DIPLOID CELL STRAIN WI-38.


ESTROGENS AND CORTICOIDS IN RELATION TO MAMMARY GLAND GROWTH IN MALE RATS.


ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XIV. STUDIES ON IMMUNOLOGICAL TOLERANCE WITH STRUCTURALLY RELATED SYNTHETIC POLYMERS.


INHIBITION OF POLIOVIRUS MINUTE-PLAQUE MUTANTS AND ECHOVIRUSES BY SULFATED POLYSACCHARIDES.


INTERCELLULAR FORCES AND SEPARATION ENERGY OF RED CELLS SLUDGED BY CONTRAST MEDIUM.


IN VIVO EFFECTS OF OUABAIN ON CALCIUM METABOLISM IN RABBIT HEARTS AND PLASMA.


FURTHER PURIFICATION OF TSH-RELEASING FACTOR (TRF) FROM SHEEP HYPOTHALAMIC TISSUES, WITH OBSERVATIONS ON THE AMINO ACID COMPOSITION.


EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS.


ANTIGENICITY OF THE PEPTIDE CHAINS ISOLATED FROM HUMAN HEMOGLOBINS A AND F.


STUDIES IN VALINE BIOSYNTHESIS. VII. AN ENZYMATIC CLUE IN PENICILLIUM CHRYSOGENUM AND OTHER ORGANISMS.


EFFECT OF CHRONIC HYPOXIA ON THE PULMONARY CIRCULATION OF CATS.


DISTRIBUTION AND GRADIENT OF LACTATE BETWEEN BLOOD AND HEART MUSCLE.


RESTORATION OF ANTIBODY PRODUCING CAPACITY IN BURSECTOMIZED CHICKENS BY BURSAL GRAFTS IN MILLIPORE CHAMBERS.


POLYVALENT GROUP B ARBOVIRUS ANTISERUM PRODUCED IN MONKEYS.


ABSENCE OF ANTIBODY PLAQUE FORMING CELLS IN SPLEENS OF THYMECTOMIZED MICE IMMUNIZED WITH SHEEP ERYTHROCYTES.


EFFECT OF BILIRUBIN ON BINDING OF THYROXINE BY HUMAN SERUM ALBUMIN.


HEMATOCRIT CHANGES IN ENDOTOXIN SHOCK.

HEMATOCRIT CHANGES IN ENDOTOXIN SHOCK.


ISOLATION OF MUCOPOLYSACCHARIDE FROM THE PRECARTILAGINOUS EMBRYONIC CHICK LIMB BUD.


EFFECT OF ENDOTOXIN ON THE TRANSFER OF FIBRINOGEN FROM PLASMA TO LYMPH.


GROWTH REPRESSION IN RATS BY THIOURACIL-IODIDE MIXTURES.


EFFECT OF FEEDING DIFFERENT AMINO ACID DIETS ON GROWTH RATE AND NITROGEN RETENTION OF WEANLING RATS.


SERTOLI CELL STIMULATION FOLLOWING INTRATESTICULAR INJECTIONS OF FSH IN THE HYPOPHYSECTOMIZED RAT.


TERATOGENIC ACTION IN RATS OF RESERPINE ALONE AND IN COMBINATION WITH SALICYLATE AND IMMOBILIZATION.


SOME BIOLOGICAL PROPERTIES OF A URINARY NORETHYNODREL METABOLITE.


ALTERATION OF RES PHAGOCYTIC FUNCTION BY PYROGEN CONTAMINATED COLLOIDAL CARBON.


RENAL EFFECTS OF HYPERCALCIURIA IN IMMOBILIZED CHILDREN.


DIFFERENCES IN HEPATIC DRUG METABOLISM IN VARIOUS RABBIT STRAINS BEFORE AND AFTER PRETREATMENT WITH PHENOBARBITAL.


EFFECT OF NOREPINEPHRINE ON MYOCARDIAL FREE FATTY ACID UPTAKE AND OXIDATION.


SOME CRITERIA FOR REMOVAL OF SKELETALLY BOUND RADIOACTIVE STRONTIUM.


HISTAMINE METABOLISM IN THE PREGNANT AND NON-PREGNANT HAMSTER.


THE ACTIVATING EFFECT OF LEAD ON THE PRECIPITATION OF CALCIUM PHOSPHATE.


INCORPORATION OF TRITIUM FROM SUCCINATE-2,3-H3 INTO LONG CHAIN FATTY ACIDS BY AORTIC MITOCHONDRIA.


STUDIES ON IMMUNE RESPONSES OF RABBITS TO RABBIT SUBMAXILLARY ANTIGENS.


PAROTID SALIVA-SERUM RATIOS OF CA-47 IN MAN FOLLOWING INTRAVENOUS ADMINISTRATION OF THE ISOTOPE.


ALTERATIONS IN THE HEMODYNAMIC RESPONSE TO E. COLI ENDOTOXIN WITH CHANGES IN THE ACID-BASE STATE.


METABOLISM OF FREE FATTY ACIDS IN OBESE HUMANS.


METABOLIC AND BIOCHEMICAL CHANGES IN TESTIS OF COTTON RAT (SIGMODON HISPIDUS) DURING BREEDING CYCLE.


RESPONSE OF INTRAOCULAR OVARIAN ISOGRAFTS TO LH IN MALE MICE.


ADRENOCORTICAL SECRETION IN ANESTHETIZED DOGS DURING HYPEROXIA, HYPOXIA AND POSITIVE PRESSURE BREATHING.


RESISTANCE TO EXPERIMENTAL TUBERCULOSIS STIMULATED BY FRACTIONS FROM ATTENUATED TUBERCLE BACILLI.


INTESTINAL TRANSPORT OF AMINO ACIDS AND GLUCOSE IN FLOUNDER FISH.


EFFECT OF CHLOROTHIAZIDE ON RAT LIVER GLUCOKINASE, HEXOKINASE AND DIHYDROXYACETONE-KINASE ACTIVITIES.


SPECIES SPECIFIC BLOOD GROUPS IN CYNOPITHECUS NIGER (CELEBES APE).


EXPERIMENTAL ENTERIC INFECTION OF CHICKENS WITH AN AVIAN ADENO-VIRUS (STRAIN 93).


TIME STUDY OF INCORPORATION IN VIVO OF INORGANIC PHOSPHATE (P32) INTO PHOSPHOLIPIDS OF MITOCHONDRIA.


A SELECTIVE MEDIUM AND COLOR TEST FOR MYCOPLASMA PNEUMONIAE.


FATTY ACID SYNTHESIS IN VITRO IN A SYSTEM FROM RAT LIVER.


PHYSICAL AND CHEMICAL PROPERTIES OF H-1 VIRUS. I. PH AND HEAT STABILITY OF THE HEMAGGLUTINATING PROPERTY.


GEL-FILTERED MEDIA FOR PURIFICATION OF EXTRACELLULAR TOXINS.


ENHANCEMENT OF ETHANOL TOXICITY BY ETHACRYNIC ACID.


STUDIES ON ETHIONINE. VII. FATTY ACID SYNTHESIS IN LIVERS OF ETHIONINE-TREATED RATS.


USE OF CELL-BANKED MONKEY KIDNEY CELLS FOR THE ISOLATION OF RESPIRATORY VIRUSES.


VENOUS-ARTERIOLAR RESPONSE IN THE CANINE LIVER.


THE METABOLISM OF A BASIC AMIDE ANALGESIC, SQ 10,269.


EFFECT OF TRITON INGESTION ON FAT ABSORPTION.


MOUSE LEUKOCYTES IN CULTURE.

MOUSE LEUKOCYTES IN CULTURE.


RESTORATION OF TYRAMINE PRESSOR RESPONSES IN RESERPINE-TREATED ANIMALS BY METHYLDOPA AND ITS AMINE METABOLITES.


PURIFICATION OF OVINE LUTEINIZING HORMONE-RELEASING FACTOR BY GEL FILTRATION AND ION EXCHANGE CHROMATOGRAPHY.


IN VITRO SYNTHESIS OF STEROIDS BY EXPERIMENTALLY INDUCED CYSTIC OVARIES.


TWO CASES OF HAIR LOSS: ONE WITH AND ONE WITHOUT HYPERTRICHOSIS.


LIVER CIRRHOSIS AND SCHISTOSOMIASIS INFECTION.


NEW CONCEPTS IN TRAUMATIC SURGERY.

NEW CONCEPTS IN TRAUMATIC SURGERY.


PAROXYSMAL BLINDNESS.

PAROXYSMAL BLINDNESS.


THE PROBLEM OF UNEXPECTED DEATH.

THE PROBLEM OF UNEXPECTED DEATH.


IN MEMORIAM: SIEGFRIED J. THANNHAUSER--1885-1962.


HUMAN CHROMOSOMES IN MEDICAL DIAGNOSIS.

HUMAN CHROMOSOMES IN MEDICAL DIAGNOSIS.


THE SURGICAL APPROACH TO THE TREATMENT OF CORONARY DISEASE. HISTORICAL REVIEW AND A NEW METHOD.


FACTS AND FALLACIES OF IONIZING RADIATION.


NEWER CONCEPTS IN DIABETES MELLITUS.

NEWER CONCEPTS IN DIABETES MELLITUS.


EARLY DIAGNOSIS IN ACUTE UPPER GASTRO-INTESTINAL BLEEDING.


THE DIAGNOSIS OF PHEOCHROMOCYTOMA.

THE DIAGNOSIS OF PHEOCHROMOCYTOMA.


IN MEMORIAM: RUDOLF A. STERN.

IN MEMORIAM: RUDOLF A. STERN.


IN MEMORIAM: GUSTAV BUCKY.

IN MEMORIAM: GUSTAV BUCKY.


MEDIASTINITIS IN A NEWBORN.

MEDIASTINITIS IN A NEWBORN.


TWENTIETH CENTURY THERAPEUTICS AND RIP VAN WINKLE.


DETECTION OF INBORN METABOLIC DISEASE IN THE YOUNG CHILD.


MALIGNANT MELANOMA (MELANOSARCOMA, MELANOCARCINOMA, NEVOCARCINOMA) WITH LATE METASTASES.


"INOPERABLE" CARCINOMA OF THE RIGHT COLON WITH INVASION OF THE URETER.


GUSTATORY SWEATING, THE AURICULO-TEMPORAL SYNDROME (FREY'S).


CHOLELITHIASIS AND PRIMARY CARCINOMA OF THE GALLBLADDER.


ULTRASONICS IN ARTHRITIS.

ULTRASONICS IN ARTHRITIS.


PHYSICAL MEDICINE AND REHABILITATION IN RHEUMATOID ARTHRITIS.


SOME ASPECTS OF DRUG THERAPY IN CERVICAL DERANGEMENTS.


RELATIONS BETWEEN THE NERVOUS SYSTEM AND REGENERATION IN THE PLANARIANS. FIRST OBSERVATIONS ON THE REGENERATIVE CAPACITY OF SPECIMENS OF DUGESIA LUGUBRIS BEFORE AND AFTER THE OPENING OF THE COCOONS.


CHANGES OF THE PERMEABILITY OF THE ISOLATED FROG HEART IRRADIATED WITH X RAYS. PROTECTIVE ACTION OF GLUCOSE, OF CYSTEAMINE AND OF SODIUM THIOSULPHATE.


DOCTORAL FEEDBACK INTO HIGHER EDUCATION.


SEROLOGIC CODES: INTERPRETATION OF IMMUNOGENETIC SYSTEMS. Transformations of serologic reaction patterns into verbal codes are analyzed. Two equally consistent and complementary models are compared. A model based on the assumption that antibodies are complex (cross-reacting) permits simpler, more uniform, and less prejudicing interpretations of immunogenetic systems than when antibodies are regarded as simple (specific).


RADIOACTIVE STRONTIUM: ESTIMATION OF THE AMOUNT ACCIDENTALLY INGESTED. If radioactive strontium is accidentally ingested or inhaled, the amount absorbed may be calculated with reasonable accuracy from the amount of calcium and strontium excreted in the urine in a single day. The amount retained by the body initially may be calculated from the amount of radiostrontium excreted in the feces in the first few days.


CONDITIONAL-LETHAL MUTANTS OF AN ANIMAL VIRUS: IDENTIFICATION OF TWO CISTRONS. Two different temperature-sensitive conditional-lethal mutants of Sindbis virus, an animal virus that contains RNA, have been isolated. When cultured in chick fibroblast monolayers at 42 degrees C, these mutants yield less than 0.05 percent as much virus as does the wild type, whereas at 27 degrees C they grow normally. One mutant appears to be altered in the synthesis of a protein that is produced early in the infection and is required for viral RNA synthesis. The other mutant produces as much infectious RNA as the wild type at 42 degrees C and appears to be altered in the synthesis of a protein produced late in the infection.


HEREDITARY ANGIONEUROTIC EDEMA: TWO GENETIC VARIANTS. Serums of patients with hereditary angioneurotic edema lack inhibitory activity against the esterase derived from the first component of complement. In one group of patients this lack appears to result from failure to synthesize the esterase inhibitor of the first component of complement, whereas in another group of patients an abnormal, nonfunctional protein is synthesized.


MUSCLE VOLUME CHANGES: RELATION TO THE ACTIVE STATE. The volume of a frog sartorius muscle increases during a single twitch and subsequently decreases. The magnitude of volume change is 10(-5) cm(3) per gram of muscle. The time courses of change in volume and of onset of tension vary with temperature in a similar way, which implies a relation between the volume changes and the contraction mechanism. The character of the change depends upon the initial length of the muscle: the greatest decrease accompanies an isometric twitch at reference length. Treatment of the muscle with an iodide Ringer solution prolongs the active state and the volume change. These results suggest a correlation between the volume changes and the active state.


DROSOPHILA PHENOL OXIDASES.

DROSOPHILA PHENOL OXIDASES. The phenol oxidase systems of Drosophila melanogaster arise from at least four protein components. One A component plus the P preparation yields tyrosinase, while the other two (A(2) and A(3)) yield primarily 3,4-dihydroxyphenylalanine oxidases. Probably the four components represent specialized subunits of the oxidases produced.


PYRAMIDAL AND NON-PYRAMIDAL PATHWAYS IN MONKEYS: ANATOMICAL AND FUNCTIONAL CORRELATION. In monkeys, corticospinal fibers terminate on motoneurons and interneurons. Brainstem fibers, which may be grouped into medial and lateral pathways, terminate on the same interneurons. Observations following bilateral pyramidotomy indicate that motility can be adequately directed by the brainstem systems while cortical connections add speed and the capacity for further fractionating movements. Further experiments suggest that the medial and lateral brainstem pathways primarily direct proximal and distal movements, respectively.


EATOMETER: A DEVICE FOR CONTINUOUS RECORDING OF FREE-FEEDING BEHAVIOR. Minor modifications of a commercially available food cup permit automatic recording of a rat's contacts with common dry food. It is thus possible to measure the frequency and duration of the "meals" that rats take over extended periods of time, and, in conjunction with existing devices for measuring drinking, to record contingencies between eating and drinking.


SOMNAMBULISM: ALL-NIGHT ELECTROENCEPHALOGRAPHIC STUDIES. Using special techniques allowing for subject mobility, we obtained continuous electroencephalographic recordings of known sleepwalkers. Somnambulistic incidents occurred during periods of slow-wave sleep. The incidents were not related temporally to dream periods, nor did they affect the total time or the percentage of time spent dreaming during the nights on which the subjects were studied.


PARODOXICAL SLEEP: DEPRIVATION IN THE CAT. In cats, the paradoxical phase of sleep occupies about 33 percent of the total sleeping time. Cats which were deprived of paradoxical sleep, by being awakened at its onset, required an increased number of awakenings on successive days of deprivation in order to prevent paradoxical sleep. On the first day of recovery after deprivation, when sleep was not experimentally interrupted, the paradoxical phase occupied 53 percent of the total sleeping time.


EVOKED POTENTIALS AND CORRELATED JUDGEMENTS OF BRIGHTNESS AS FUNCTIONS OF INTERFLASH INTERVALS. Computer-averaged evoked potentials were recorded from subjects presented with pairs of flashes having equal light energy but differing in duration of the brief interval separating the flashes. For the experimental conditions studied, the pair was always subjectively fused. Although the brightness did not change noticeably as the interval was varied, the use of the forced-choice psychophysical technique showed that apparent brightness declined with increase in the interval. Analysis of the evoked potentials revealed a correlated change in amplitude and wave form previously demonstrated for changes in flash flux alone.


SOME KINETIC PROPERTIES OF A DETERMINISTIC EPIDEMIC CONFIRMED BY COMPUTER SIMULATION. Representative epidemic transients were generated by computer by a known, plausible mechanism. Accurate retrieval of the individual rate constants and confirmation of their predictive value resulted from a manual test of the mechanism by which the computer outputs were generated. The method is applicable in principle to any regenerative process opposed by exponential decay.


INHIBITION OF SPERMATOGENESIS AND ATROPHY OF THE TESTIS CAUSED BY NITROFURAN COMPOUNDS.


THE NATURE OF MASUGI NEPHRITIS; HISTO- AND IMMUNOPATHOLOGICAL STUDIES.


EXPERIMENTAL STUDIES ON BRAIN TUMORS.

EXPERIMENTAL STUDIES ON BRAIN TUMORS.


INDUCTION OF A DISEASE RESEMBLING SYSTEMIC LUPUS ERYTHEMATOSUS IN LATER STAGE OF PROLONGED SENSITIZATION IN RABBITS.


CYTOTOXIC EFFECTS OF THE MYCOTOXINS OF PENICILLIUM ISLANDICUM SOPP, LUTEOSKYRIN AND CHLORINE-CONTAINING PEPTIDE ON CHANG'S LIVER CELLS AND HELA CELLS.


HISTOPLASMOSIS OF THE KIDNEY. A CASE REPORT FROM JAPAN.


PACEMAKER TREATMENT IN THE ADAMS-STOKES SYNDROMA.


THE EFFECT OF BIS(P-ACETOXYPHENYL)CYCLOHEXYLIDENE-METHANE (COMPOUND F 6066) ON HORMONE EXCRETION IN POSTMENOPAUSAL WOMEN.


TRANSFER OF ROUS SARCOMA BY CELLS TO CHICKENS IMMUNIZED AGAINST ROUS SARCOMA VIRUS.


THE D-XYLOSE TEST IN HEALTHY INFANTS AND CHILDREN.


THE EFFECT OF CIGARETTE SMOKING ON THE BLOOD FLOW OF THE SKIN, MUSCLE AND NASAL MUCOSA.


LACK OF EFFECT OF PREDNISOLONE TREATMENT ON THE SURVIVAL OF SULFHYDRYL INHIBITED ERYTHROCYTES IN THE DOG.


AGE-DEPENDANT IN VITRO AND IN VIVO DESTRUCTION OF HUMAN AND DOG RED BLOOD CELLS INDUCED BY P-HYDROXYMERCURIBENZOATE.


EUROPEAN CONFERENCE ON AIR POLLUTION STRASBOURG, 24 JUNE-1 JULY, 1964.


CLINICAL EFFECTS OF BIS(P-ACETOXYPHENYL)-CYCLOHEXYLIDENEMETHANE (COMPOUND F 6066) ON MENSTRUAL DISORDERS.


NYLON CONSTRICTION MICROPIPETTES.

NYLON CONSTRICTION MICROPIPETTES.


RESPIROMETER ASSEMBLY FOR BOD MEASUREMENT OF RIVER WATERS AND BIOLOGICALLY TREATED EFFLUENTS.


LIGATION OF THE PANCREATIC DUCT IN RATS.


A LABORATORY STUDY OF THE EFFECT OF SHORT-CIRCUITING UPON THE COMPLETELY-MIXED ACTIVATED SLUDGE PROCESS.


THE STATISTICAL EVALUATION OF ROUND-ROBIN DATA.


COMPARISON OF LIPID EXTRACTION METHODS.

COMPARISON OF LIPID EXTRACTION METHODS.


GALLBLADDER DISEASE IN NUNS.

GALLBLADDER DISEASE IN NUNS.


RECOVERY OF ORGANICS FROM A EUTROPHIC LAKE BY THE CARBON ADSORPTION TECHNIQUE.


THE SUSCEPTIBILITY OF SALMONID FISH TO POISONS UNDER ESTUARINE CONDITIONS. II. AMMONIUM CHLORIDE.


THE IMPORTANCE OF RECTAL BIOPSY IN THE DIAGNOSIS OF AMEBIASIS.


DUODENAL AND GASTRIC ULCERS IN SYSTEMIC SCLERODERMA.


COMPLICATIONS FOLLOWING REPAIR OF ESOPHAGEAL HIATUS HERNIA.


PROCTOSCOPIC FINDINGS IN 1,000 CLINIC PATIENTS.


FAN FLAPS IN CHEILOPASTY.

FAN FLAPS IN CHEILOPASTY.


RUPTURE OF THE AXILLARY ARTERY AS A COMPLICATION OF DISLOCATION OF THE SHOULDER.


A CASE OF GASTROMALACIA WITHOUT CEREBRAL LESIONS.


SPLENECTOMY.

SPLENECTOMY.


CAVERNOUS HAEMANGIOMAS OF THE MEDIASTINUM.


PERFORATION OF THE COLON CAUSED BY INFECTION WITH ENDAMOEBA HISTOLYTICA.


USE OF THE ILO CLASSIFICATION IN THE STUDY OF SILICOSIS. THE INTERNATIONAL CLASSIFICATION OF ROENTGENOGRAMS (1958) WITH SLIGHT MODIFICATIONS.


FINE STRUCTURE OF FUNGI AS REVEALED BY ELECTRON MICROSCOPY.


THE ENZYMIC BASIS OF SPECIFIC ANTIBACTERIAL ACTION BY STRUCTURAL ANALOGUES.


ADAPTATION OF MICE TO COLD.

ADAPTATION OF MICE TO COLD.


EARLY MEDICAL PRACTICE IN BATH.

EARLY MEDICAL PRACTICE IN BATH.


A STUDY OF THE ARTERIAL CLEARANCE OF XENON 133 IN MAN.


DURATION OF THE NEUROMUSCULAR BLOCKING ACTION OF STREPTOMYCIN.


PROLONGED NASOTRACHEAL INTUBATION. A REVIEW OF ITS DEVELOPMENT IN A PAEDIATRIC HOSPITAL.


THE IMMEDIATE POSTOPERATIVE CARE OF THE MYASTHENIC PATIENT FOLLOWING THYMECTOMY.


ANAESTHESIA IN PATIENTS WITH SICKLE-CELL ANAEMIA.


THE RELATIONSHIP BETWEEN MOLECULAR CLASSES OF GAMMA GLOBULINS AND ANTIBODIES TO SULFANILAZO HAPTEN.


EFFECT OF TRIMETAPHAN ON HAEMODYNAMICS AND OXYGEN CONSUMPTION DURING HALOTHANE ANAESTHESIA IN MAN.


THE ANAESTHETIST AND THE EARLY MANAGEMENT OF ACUTE HEAD INJURIES.


GAS-HOLDING APPARATUS FOR USE IN GAS CHROMATOGRAPHY.


REPEATED CARDIAC ARREST WITH HALOTHANE: A CASE REPORT.


THE CLINICAL EVALUATION OF NARCOTIC AND SEDATIVE DRUGS. II. A RE-EVALUATION OF PETHIDINE AND PETHILORFAN.


FAMILIAL CUTANEOUS PORPHYRIA.

FAMILIAL CUTANEOUS PORPHYRIA.


ICHTHYOSIFORM CONDITIONS OCCURRING IN LEPROSY.


KWASHIORKOR IN THE UNITED ARAB REPUBLIC.


EXPERIENCES OF INFECTIOUS SYNOVITIS IN BROILER BREEDING STOCK AND BROILER CHICKENS, WITH PARTICULAR REFERENCE TO THE NATURAL SPREAD OF THE DISEASE.


BIOCHEMICAL, SEROLOGICAL AND HAEMATOLOGICAL CHANGES ASSOCIATED WITH INFECTIONS OF CALVES WITH THE NEMATODE PARASITE, OSTERTAGIA OSTERTAGI.


SOME CHEMICAL INFLUENCES ON HAIR GROWTH AND PIGMENTATION.


TESTS FOR ACTIVITY AGAINST HISTOMONAS MELEAGRIDIS: USE OF THE INFECTION IN CHICKENS AND A COMPARISON OF THE RESULTS OBTAINED IN CHICKENS AND TURKEYS.


A METHOD OF MEASURING FOOD PASSAGE RATE IN PIGS BY MEANS OF POLYSTYRENE MARKERS.


STUDIES ON CHRONIC COPPER POISONING. IV. BIOCHEMISTRY OF THE TOXIC SYNDROME IN THE CALF.


POST-GRADUATE PROGRAM.

POST-GRADUATE PROGRAM.


ANOPHELES GAMBIAE, A COMPLEX OF SPECIES. The author reports on some 200 laboratory crossings of 36 strains of Anopheles gambiae from many different parts of Africa which show the existence of five mating-types in what was until recently considered a single species. Three of these mating-types are freshwater forms and have been provisionally called A, B and C. Two are saltwater forms: A. melas, confined to West Africa, and the East African A. merus. Hybrid male sterility is universal when any two of these five forms are crossed, and from some of the crosses grossly abnormal sex-ratios result. From an evolutionary standpoint these five mating-types are probably species or semi-species in view of the fact that they can be found to co-exist sympatrically and still retain their identities. From a practical point of view it may be necessary for the field worker to be able to identify the exact species with which he is dealing before the most efficient means of controlling it can be found.


"SALTWATER ANOPHELES GAMBIAE" ON MAURITIUS. In this paper the author reports the results of three months' study of the saltwater-breeding member of the Anopheles gambiae complex of sibling species on Mauritius.There is evidence for the views that this form's distribution on the island is limited by the availability of suitable breeding areas, that it does not usually disperse far from the breeding grounds or coast, and that it is probably not an important vector except, perhaps, in the near vicinity of its breeding places.Some new evidence is presented in support of the view that this form (and forms A and B) are distinct species. This turns on the observed close coexistence of these three forms on Mauritius, supported by a theoretical consideration of what would be expected to happen in such circumstances if a system of random mating prevailed.Evidence is given that the Mauritian saltwater-breeding form of the A. gambiae complex is conspecific with the form occurring on the east coast of Africa.The practical importance of reaching general agreement on the evolutionary status of the members of the A. gambiae complex is emphasized.


STUDIES ON THE KINETIC RESPONSE OF MOSQUITOS TO CHEMICALS. An apparatus is described for study of the activity of mosquitos either with or without stimulation by exposure to insecticides or other chemicals such as repellents. Batches of up to 30 mosquitos can be used and they can be studied for a longer time than is possible with, for instance, the method put forward in 1960 by the WHO Expert Committee on Insecticides. Random activity by the test insects, in the absence of directional stimuli due to light or chemicals, is converted to progress through baffles in the partitions separating a series of four boxes and is expressed as a percentage of the total possible activity that would be shown if all the insects passed all the baffles. Exposure to chemicals, by exposure to impregnated papers, can take place before the mosquitos are put in the apparatus, or in the first box. In the experiments described, the activity of recently fed female Anopheles was studied over periods of up to 20 hours.Comparison of the method described with other methods shows that it shares the high variance characteristic of all current procedures for studying mosquito behaviour, although the use of large numbers of insects over long periods has some advantages. The method does, however, give information on mortality under conditions of facultative contact that may be a valuable supplement to the results of conventional susceptibility tests.


THE MONOFACTORIAL INHERITANCE OF RESISTANCE TO DIELDRIN IN LARVAL AND ADULT CULEX QUINQUEFASCIATUS SAY. A susceptible and a resistant strain were isolated from an originally heterogeneous laboratory colony of Culex quinquefasciatus Say (= Culex pipiens fatigans Wiedemann) by use of discriminating concentrations of dieldrin on fourth-instar larvae. By cross-breeding, hybrids of intermediate susceptibility were obtained. By repeated cross-breeding and elimination of susceptibles the authors have shown that resistance to dieldrin is controlled by a single inheritable factor which is neither fully recessive nor dominant in the hybrid genotype, since the ratios of the LC(50) values were 1:19:196. Cross-resistance was shown to lindane but not to malathion or to any of three carbamates.Similar tests were made with adult females exposed to papers impregnated with n-dioctyl phthalate as solvent to secure high concentrations of dieldrin. Resistance in this stage also was neither fully recessive nor dominant, but it can be calculated quantitatively only for the hydrid (approximately 15-fold) since longer exposure was required with the resistant genotype. Determination of dieldrin pick-up showed that this cannot account for the differences in susceptibility of the genotypes. Analysis of resistant females surviving exposure to dieldrin papers showed slow loss of dieldrin and thus added confirmation to the hypothesis that metabolism is not the controlling process in dieldrin-resistance.


POTENTIATION OF ACTIVITY OF DIAPHENYLSULFONE AND PYRIMETHAMINE AGAINST PLASMODIUM GALLINACEUM AND PLASMODIUM CYNOMOLGI BASTIANELLII. In view of the fact that diaphenylsulfone has been shown to have low schizontocidal activity against Plasmodium gallinaceum and to lead to resistance in strains of P. cynomolgi, investigations were undertaken into the joint action of diaphenylsulfone and pyrimethamine against P. gallinaceum in chicks and P. cynomolgi bastianellii in monkeys. These drugs were assayed separately and in various combinations. It was found that at certain dose levels combination of the two drugs led to potentiation of their plasmocidal activity. On the other hand, this synergistic effect was not noted with combinations containing lower dosages of either drug; with these, a simple additive effect occurred. The authors suggest that the two drugs probably act on the same metabolic pathway but that their points of attack may be different. They note also that there was a difference in the response of P. gallinaceum in chicks and of P. cynomolgi bastianellii in monkeys to the combined use of the two drugs.


EPIDEMIOLOGICAL DATA CONCERNING ONE YEAR OF A MALARIA SURVEILLANCE PILOT PROJECT IN SOUTHERN RHODESIA. Few factual data have been published on the problem of disappearing malaria due to Plasmodium falciparum in Africa. In Southern Rhodesia a surveillance project has been under way since January 1961. The author describes malaria surveillance procedures, methods, organization and costs for the year 1962-63 and presents data relevant to a sparsely populated part of rural Africa where a surveillance visitor can cover a population of only some 3500 by monthly house-to-house visits. Through such visits, and through special surveys, an annual blood examination rate of 25% was achieved in the area at fairly low cost.It was found in the area studied, where 98% of infections are due to P. falciparum, that even Africans who have previously attained a high level of immunity will produce typical fever and associated malaria symptoms on reinfection after several years. Methods of case detection have proved adequately sensitive, despite the problem of asymptomatic carriers and despite the difficulty of obtaining true medical histories. Evidence is produced that much residual low-level transmission occurs indoors, although Anopheles gambiae are found in low density in human dwellings. Drug dosages and preventive treatment are described in detail; to reduce the number of asymptomatic carriers, single-dose presumptive treatment is advocated, at least in the last year of the attack phase. Many of the findings presented will be applicable to other African countries where malaria has been reduced to a low incidence.


PARTIAL SUPPRESSION OF MALARIA PARASITES, AND OF THE TRANSMISSION OF MALARIA, IN AEDES AEGYPTI (L.) DOUBLY-INFECTED WITH SEMLIKI FOREST VIRUS AND PLASMODIUM GALLINACEUM BRUMPT. Laboratory experiments were undertaken with Aedes aegypti infected with both Semliki Forest virus (SFV) from infant mice and Plasmodium gallinaceum from fowls to determine if such double infection of mosquitos suppressed their ability to transmit the malaria parasite, a possibility suggested to explain reduction in malaria transmission in Uganda in 1960 when Anopheles funestus and Anopheles gambiae were transmitting both malaria and o'nyongnyong virus to the African population. In general, transmission of fowl malaria was not prevented by SFV infection in Aedes, although some malariometric indices, and consistently the mean oocyst count, were slightly lower in doubly-infected mosquitos than in controls. In one experiment, however, 60% of the Aedes infected 8 days previously with SFV died within 48 hours of ingesting a malarious meal. Mortality was selectively in favour of the survival of SFV-infected mosquitos negative for, or least heavily infected with, malaria; depression in the presence of the virus of the intensity of malaria infection in the individual Aedes also occurred. Some physiological factor-a stress in adult life or, possibly more important, suboptimal larval nutrition-appears to have been crucial to eliciting the adverse effect on the mosquitos themselves and on their malaria infections. Suppression of the development of a malaria parasite in a mosquito, and of malaria transmission, by concurrent infection of the vector with an arbovirus can happen, but is by no means inevitable.It is shown that a doubly-infected Aedes can transmit both Semliki Forest virus and P. gallinaceum simultaneously.


TOXICITY OF METEPA TO RATS WITH NOTES ON TWO OTHER CHEMOSTERILANTS. Although tepa, metepa, and apholate are only moderately toxic to rats by the oral route, the dermal toxicity of the first two is relatively high as compared with that of conventional insecticides. In the experiments reported, metepa caused no damage to the intestinal epithelium of rats, except following single doses in the fatal range. The organ primarily affected by repeated small doses of metepa is the testis; the ovaries and bone marrow are damaged only by higher dosage levels. Metepa at an oral dosage of 5 mg/kg/day (about 4% of the acute oral LD(50) level daily) produced severe reduction of fertility of male rats within 22 days, sterility within 70 days, and testicular atrophy within 77 days. Half that dosage produced a smaller reduction in fertility and only partial testicular atrophy in some rats within 197 days. Dosages of 1.25 mg/kg/day or less produced no detectable effect on fertility and no histological change in the testis in 197 days. The survival of newborn rats was not affected by any dosage given to their sires.


OBSERVATIONS ON THE LONGEVITY OF PLASMODIUM FALCIPARUM: WITH SPECIAL REFERENCE TO FINDINGS IN MAURITIUS.


A SIMPLIFIED LEUKOCYTE TECHNIQUE FOR THE STUDY OF HUMAN CHROMOSOMES.


ORGANIZING A CYTOLOGY SERVICE TO ACCOMMODATE A POPULATION SCREENING PROGRAMME.


THE TOXICOLOGY OF CHEMOSTERILANTS.

THE TOXICOLOGY OF CHEMOSTERILANTS. Sterilization of males can in certain circumstances be more efficient than killing as a method for control of insects and perhaps other pests. A number of chemicals (chemosterilants) show promise of producing sexual sterility in insects without some of the practical limitations of radiation. The most important compounds are alkylating agents. These have little immediate pharmacological action, but are notable for their selective action against haematopoietic and some other proliferating tissues. A number of alkylating agents have been shown to be mutagens in insects, bacteria, fungi, and higher plants; carcinogens in mammals; and teratogens in insects, birds, and mammals. Some produce sexual sterility, possibly in mammals as well as in insects, at doses too low to produce the other effects. Some have an established reputation as drugs for palliative treatment of leukaemia and other neoplasms.The development of insect sterilization as a vector control technique has been handicapped in part by lack of scientific information on the acute and long-term hazards that might be associated with the use of chemosterilants. In this paper the author brings together the available knowledge on the toxicology of the alkylating agents.


STUDIES ON SIMIAN MALARIA IN BRAZIL.

STUDIES ON SIMIAN MALARIA IN BRAZIL.


THE USE OF PROTEOLYTIC ENZYMES WITH SPECIAL REFERENCE TO TRYPSIN AND PAPAIN, AS EXEMPLIFIED BY THREE CASE HISTORIES.


PROBLEMS IN THE ASSAY OF COAGULATION FACTORS.


A PILOT STUDY OF APPLICATIONS TO THE FOUR ONTARIO MEDICAL SCHOOLS FOR ADMISSION TO THE FIRST PROFESSIONAL YEAR. In the fall of 1964, newspaper accounts of the medical school applicant situation in Canada reported that hundreds of fully qualified applicants were being turned away because of shortage of places. Such reports precipitated a pilot study of the applications received by the four Ontario medical schools for the first professional year of medicine and it was found, first of all, that the total of 1352 applications represented only 880 individuals. Nearly 32% of these applicants were American and 18% were citizens of Commonwealth or other countries. While a majority of the applicants met the minimal requirements of the schools, very few of the rejected applicants had academic records that justified admission when the informal standards of the schools were applied. It was concluded that it is erroneous to speak of a surplus of well-qualified applicants at the present time and that the need for recruiting programs still remains.


ON TRAINING MEDICAL TEACHERS.

ON TRAINING MEDICAL TEACHERS. Neither clinical competence nor research skill can any longer be regarded as sufficient qualification for the role of teacher in medicine. If he is to be judged well prepared, the contemporary medical educator should be not only sufficiently familiar with educational science to plan wise educational strategy but sufficiently skilled in the use of instructional techniques to select and use sound educational tactics. His preparation for this role should be a matter of plan rather than accident. The six-week program described here is intended to provide an introductory opportunity for such training.


A RESEARCH PROGRAM IN MEDICAL EDUCATION IN CANADA. The current interest in medical education and the proposed expansion of medical education facilities have stimulated the development of a research program by the secretariat of the Association of Canadian Medical Colleges. The projects planned and now in progress include: (1) studies of the cost of medical education in Canadian teaching hospitals and medical schools; (2) a study of the basic medical science departments in Canada with special reference to the occupational careers of scientists who have received M.Sc. and Ph.D. degrees in those departments; (3) establishment of a student registry to facilitate prospective studies of Canadian medical students; (4) a survey of the residents in training in Canadian hospitals to obtain their evaluation of their training experience.


PROGRAMMED INSTRUCTION: NEW BOTTLE FOR REDISCOVERED WINE. Programmed instruction is attracting attention at all educational levels. While this approach is new, the educational principles it incorporates are well established: instructional goals are defined in advance, the content is meticulously organized, active student participation is demanded, immediate feedback is provided to students, and each instructional unit is subjected to testing and revision. With its established effectiveness as a vehicle for introducing new topics, and for providing remedial and supplementary instruction, it can free the medical teacher to devote his time to matters which are more deserving of his attention, such as identifying and responding to individual student needs, exploring complex concepts, and working directly with students to provide a model and critical supervision. A more important potential contribution of programming may be that it has reminded us of sound educational precepts which deserve our attention in all forms of instruction.