REDUCTION OF SERUM TRIGLYCERIDES AND CHOLESTEROL BY ETHYL P-CHLOROPHENOXY-ISOBUTYRATE (CPIB).


CONFIRMATION OF CLOSURE OF VENTRICULAR SEPTAL DEFECTS: VALUE OF VASOPRESSOR AGENTS.


PAROXYSMAL FLUTTER OF THE DIAPHRAGM: A REPORT OF FIVE CASES.


SPONTANEOUS CLOSURE OF TRAUMATIC VENTRICULAR SEPTAL DEFECT.


SURGERY FOR VENTRICULAR SEPTAL DEFECT IN DEXTROVERSION THROUGH A LEFT VENTRICULOTOMY.


ALDOSTERONE AND THE EDEMA OF CONGESTIVE HEART FAILURE.


TRANSFUSION OF ERYTHROCYTE-GLYCEROL MIXTURES AFTER PROLONGED STORAGE AT LOW TEMPERATURES.


LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION.


INTRAPERITONEAL ANTIBIOTIC ADMINISTRATION: RATE OF ABSORPTION ACROSS NORMAL PERITONEUM.


ACUTE RENAL FAILURE FOLLOWING ORAL CHOLECYSTOGRAPHY: A UNIQUE NEPHROGRAPHIC EFFECT.


HEMOCHROMATOSIS AND CIRRHOSIS IN DIFFERENT GEOGRAPHIC AREAS.


UPPER RESPIRATORY ILLNESSES IN NAVAL PERSONNEL.


A METHOD OF EVALUATION IN MULTIPLE SCLEROSIS USING ADENOSINE-5-MONOPHOSPHATE.


SICKLE-CELL TRAIT IN BLOOD DONORS.

SICKLE-CELL TRAIT IN BLOOD DONORS.


EFFECTIVENESS AND TOXICITY OF PROLONGED INFUSIONS OF 5-FLUOROURACIL IN THE TREATMENT OF CANCER.


ENHANCING BLOOD FIBRINOLYTIC ACTIVITY BY A NIACIN COMPOUND. II. ACTIVATION AND NONACTIVATION.


A CASE OF NEUTROPHILIC LEUKEMIA.

A CASE OF NEUTROPHILIC LEUKEMIA.


THE HEMODYNAMIC EFFECTS OF INFUSIONS OF LONG CHAIN SATURATED FATTY ACIDS INTO DOGS.


VANILLYMANDELIC ACID EXCRETION IN LABILE HYPERTENSIVE SUBJECTS: ITS VARIATION AND RESPONSE TO NOREPINEPHRINE AND ANGIOTENSIN INFUSION.


SUDDEN, UNEXPECTED, NATURAL DEATH.

SUDDEN, UNEXPECTED, NATURAL DEATH.


DISTINCTIONS ARE NECESSARY.

DISTINCTIONS ARE NECESSARY.


MUSCULAR SUBAORTIC STENOSIS MASQUERADING AS MYOCARIDAL INFARCTION.


EPIDEMIC NEUROMYASTHENIA: THE SPORADIC FORM.


DIPLOMA PROGRAMS NEED SCRUTINY.

DIPLOMA PROGRAMS NEED SCRUTINY.


MOTHERS' PERCEPTIONS OF CARE GIVEN THEIR DYING CHILDREN.


REFRESHER PRACTICE.

REFRESHER PRACTICE.


OAT-CELL LUNG CANCER.

OAT-CELL LUNG CANCER.


HEMOSTASIS AND BLOOD COAGULATION.

HEMOSTASIS AND BLOOD COAGULATION.


WHO AID TO MIDWIFERY IN CHILE.

WHO AID TO MIDWIFERY IN CHILE.


ANOTHER APPROACH TO PROFESSIONALISM.

ANOTHER APPROACH TO PROFESSIONALISM.


AN INSULIN INJECTION TECHNIQUE FOR PREVENTING SKIN REACTIONS.


ON THE PATIENTS' TERMS.

ON THE PATIENTS' TERMS.


ELECTRONIC MONITORING OF VITAL SIGNS.

ELECTRONIC MONITORING OF VITAL SIGNS.


THE CORONARY CARE AREA.

THE CORONARY CARE AREA.


NURSING IN A CORONARY CARE UNIT.

NURSING IN A CORONARY CARE UNIT.


HEMODIALYSIS FOR ACUTE RENAL FAILURE.

HEMODIALYSIS FOR ACUTE RENAL FAILURE.


GOOD NUTRITION FROM FOOD NOT PILLS.

GOOD NUTRITION FROM FOOD NOT PILLS.


THE NURSE AND URBAN RENEWAL.

THE NURSE AND URBAN RENEWAL.


PARTICIPANTS--NOT PATIENTS.

PARTICIPANTS--NOT PATIENTS.


FACIAL FRACTURES.

FACIAL FRACTURES.


FACIAL FRACTURES: NURSING CARE.

FACIAL FRACTURES: NURSING CARE.


AGGRAVATION OF CHRONIC DISEASE IN INDUSTRY.


EVOLUTION OF OUR CONCEPTS OF STANDARDS.

EVOLUTION OF OUR CONCEPTS OF STANDARDS.


SOVIET AND AMERICAN STANDARDS FOR INDUSTRIAL HEALTH.


LABORATORY WASTE DISPOSAL.

LABORATORY WASTE DISPOSAL.


BERYLLIUM, 1964--TOXICITY AND HANDLING.

BERYLLIUM, 1964--TOXICITY AND HANDLING.


ECONOMIC GROWTH: KEY TO AIR CONSERVATION PROGRESS.


WORKMEN'S COMPENSATION LEGISLATION, 1964.


COMPENSATION CLAIMS FOR LOSS OF HEARING: IMPACT OF STANDARDS.


WALSH-HEALEY PUBLIC CONTRACTS ACT.

WALSH-HEALEY PUBLIC CONTRACTS ACT.


RECENT ADVANCES IN PHYSICAL METHODS OF ANALYSIS.


COMMENTS ON HEAT AS A PROBLEM IN INDUSTRIAL HYGIENE.


FEDERAL HAZARDOUS SUBSTANCES LABELING ACT.


PESTICIDE PROBLEMS.

PESTICIDE PROBLEMS.


THE PROBLEM OF INTERPRETING BIOSPECIMEN ANALYSES.


INDUSTRIAL CONTRIBUTION TO THRESHOLD LIMIT VALUES.


EAR PROTECTORS; THEIR USEFULNESS AND LIMITATIONS.


USE OF A VORTEX TUBE IN SAFETY CLOTHING.


ENGINEERING INDUSTRIAL ENVIRONMENTS.

ENGINEERING INDUSTRIAL ENVIRONMENTS.


THE LASER HAZARD.

THE LASER HAZARD.


EVAPORATIVE COOLERS. THEIR PLACE IN MODERN INDUSTRY.


THE PLANT ENGINEER AND AIR POLLUTION CONTROL.


APPLICATION OF GOOD SAMARITAN ACTS TO THE INDUSTRIAL HEALTH FACILITY.


POWER OF THE STATE TO IMPOSE MEDICAL TREATMENT: TRANSFUSIONS, IMMUNIZATIONS, AND GENERAL MEDICAL CARE.


MEDICAL PROBLEMS IN OVERSEAS OPERATIONS.


SKIN HYGIENE AND DERMATITIS IN INDUSTRY.


PERSONAL PROTECTIVE EQUIPMENT FOR EMPLOYEES IN INDUSTRY: A GUIDE FOR OCCUPATIONAL HEALTH PHYSICIANS.


THE PRESENT STATUS OF PATHOLOGY IN ENVIRONMENTAL HEALTH.


MONOCROTALINE-INDUCED ATHEROMATOUS LESIONS: CORONARY ARTERY OF THE RAT.


BASEMENT MEMBRANE ANTIGENS UNDER PATHOLOGICAL CONDITIONS: ALTERATIONS IN THE IMMUNOHISTOLOGIC APPEARANCE OF MEMBRANE ANTIGENS IN THE PLACENTA OF THE D2-HYPERVITAMINOTIC RAT.


AORTIC ATHEROSCLEROSIS INTENSIFICATION IN RABBITS BY PRIOR ENDOTHELIAL DENUDATION.


SPONGY DEGENERATION OF THE CENTRAL NERVOUS SYSTEM: CASE OF HOMOCYSTINURIA.


CHOLINE DEFICIENCY IN BABOON AND RAT COMPARED.


FLUOROCHROME STAINING OF JUXTAGLOMERULAR CELL GRANULES.


DIRECT ARTERIOVENOUS ANASTOMOSES IN THE KIDNEY.


THE ARTHROGRYPOSIS SYNDROME IN CHICKENS: CLINICAL, PATHOLOGIC, AND ROENTGENOGRAPHIC STUDY.


ARTERIOSCLEROSIS IN THE OSTRICH, RHEA, AND EMU: NATURALLY OCCURRING LESIONS OF THE AORTAS AND CORONARY ARTERIES.


HEPATIC PORPHYRIA. BIOCHEMICAL AND HISTOENZYMATIC STUDIES.


PATHOLOGY OF THE NEVOID BASAL CELL CARCINOMA SYNDROME.


EXPERIMENTAL COR PULMONALE IN THE RAT.

EXPERIMENTAL COR PULMONALE IN THE RAT.


DISABILITY EVALUATION: THE PORTAGE TICKET TO REHABILITATION.


LOCALIZATION OF SPECIFIC ANTIGEN IN HUMAN WARTS.


DISABILITY EVALUATION.

DISABILITY EVALUATION.


PANEL ON FORENSIC MEDICINE.

PANEL ON FORENSIC MEDICINE.


A THESAURUS OF RHEUMATOLOGY.

A THESAURUS OF RHEUMATOLOGY.


SYMPOSIUM ON MUSCLE DISEASE.

SYMPOSIUM ON MUSCLE DISEASE.


CHANGES IN THE REDOX QUOTIENT OF UBIQUINONE, SUBSTRATE LEVELS, AND ENERGY-RICH PHOSPHATES INDUCED BY METABOLIC INHIBITORS IN ISOLATED GUINEA PIG ATRIA.


THE DETERMINATION OF THE LEVEL AND REDOX  QUOTIENT OF UBIQUINONE50 (COENZYME Q10) IN GUINEA PIG HEART IN VIVO.


THE BIOLOGY OF CORAL ATOLLS.

THE BIOLOGY OF CORAL ATOLLS.


SLIME MOLDS AND RESEARCH.

SLIME MOLDS AND RESEARCH.


CELL DIVISION.

CELL DIVISION.


HOMEOSTATIC REGULATION.

HOMEOSTATIC REGULATION.


PHOTOPERIODISM IN ANIMALS.

PHOTOPERIODISM IN ANIMALS.


POPULATION GENETICS.

POPULATION GENETICS.


THE BATTERED CHILD SYNDROME. RESPONSIBILITIES OF THE PATHOLOGIST. A pathologist working in a medical examiner's or coroner's office dealing with the syndrome of the battered child is responsible for performing a complete external examination of the body with careful detailed description of all injuries, supplemented by roentgenograms of the entire skeleton, taken before the autopsy, to determine the existence of old or recent bone injury. The complete autopsy with microscopic studies must include the dissection and microscopic study of the osseous lesions.All findings possibly related to trauma are recorded in diagrams and photographs in color. The pathologist's findings and police reports dealing with the circumstances of the injuries and death must be evaluated with utmost care to determine whether inconsistencies exist in their statements as to the time and the nature of the events associated with the injuries. When confronted with the findings, suspects frequently confess.


DYSPHONIA DUE TO UNILATERAL NERVE PARALYSIS. TREATMENT BY THE INTRACORDAL INJECTION OF SYNTHETICS--A PRELIMINARY REPORT. The injection treatment of unilateral recurrent vocal cord nerve paralysis, successfully performed 40 years ago with paraffin, has recently been reintroduced with non-reactive synthetics. Improvement in the voice far and above that which can be achieved by voice therapy or any practicable surgical procedure has been demonstrated by several investigators. The technique is relatively simple, and there are no significant untoward reactions. Judging from experimental and clinical studies with these inert materials when introduced into other parts of the body, adverse long range effects are not likely to occur in the larynx. Eleven of 12 patients treated by injection of silicone or Teflon paste had substantial improvement in vocal quality and strength. Silicone was absorbed slowly from the injection site and the improvement was not enduring; when Teflon was used, it stayed at the site and the improvement was sustained.


PANCREATIC DISEASE IN INFANCY AND CHILDHOOD. SURGICAL IMPLICATIONS. Surgeons whose practice involves many infants and children should be acquainted with all abnormalities of pancreatic malformation and function. Conditions amenable to surgical treatment are few, but serious. Trauma to the pancreas in childhood is most commonly diagnosed by fever, leukocytosis, rectus spasm and elevated serum amylase. Drainage of the lesser sac and debridement of devitalized tissue may prevent the sequelae of pseudocyst formation which seems to follow the untreated injury. True congenital cysts are characterized by an epithelial lining.Mucoviscidosis complicated by meconium ileus remains a challenging disease of the newborn that requires early operation. Ten per cent of infants with cystic fibrosis may be threatened by intestinal obstruction from this cause. Some children surviving the newborn period go on to develop obstruction later. Annular malformation of pancreas may produce upper intestinal (duodenal) obstructive symptoms immediately after birth. Surgical correction by duodenojejunostomy should be postponed only long enough to correct severe fluid or electrolyte imbalances. Idiopathic spontaneous hypoglycemia has the most serious prognosis if convulsions are allowed to recur. Increased metabolic rates in infants increase the need for control of blood sugar levels by either administration of cortisone or pancreatic resection. If adenoma is the cause, a conservative resection of the tumor suffices. If serial frozen section fails to reveal either tumor or hypertophy of insulin-producing cells, blind pancreatectomy may be indicated, for irreversible brain damage develops early in uncontrolled hypoglycemia.


THE ANXIOUS PATIENT.

THE ANXIOUS PATIENT. Anxiety appears in many disguises and mimics most other afflictions. Once the anxious patient has been recognized as such and a proper diagnosis is made, management of him is easily carried out within the framework of the medical transaction. Lack of awareness of underlying anxiety in a patient who presents with somatic complaints can lead to poor results for the patient and frustration for the physician. It is not the physician's role to remove all anxiety. Rather, it is his mission to manage the anxious patient so as to mediate the anxiety allowing for integrated adaptive function.


INJURY TO THE THROWING ARM. A STUDY OF TRAUMATIC CHANGES IN THE ELBOW JOINTS OF BOY BASEBALL PLAYERS. X-ray studies were made of both elbows of 162 boys in the 9 to 14 year age group, divided into three categories: Pitchers, non-pitchers, and a control group who had never played organized baseball. Changes involving the medial epicondylar epiphysis and opposing articular surfaces of the capitulum and head of radius in the throwing arm appeared to be in direct proportion to the amount and type of throwing. The most striking changes were in the arms of pitchers. Some degree of accelerated growth, separation and fragmentation of the medial epicondylar epiphyses was noted in the throwing arm of all 80 pitchers in the study. Five cases of traumatic osteochondritis of the capitulum and head of radius, and one case of juvenile osteochondritis of the head of the radius were also found among the pitchers. Better medical supervision and stress on prevention are needed, especially in the Southern California area where climatic conditions favor prolonged seasons and throwing practice the year around.


OSTEOTOMY OF CERVICAL PART OF THE SPINE FOR ANKYLOSING SPONDYLITIS WITH SEVERE DEFORMITY.


CARCINOMA OF THE COLON COMPLICATING ULCERATIVE COLITIS WITH FIVE-YEAR SURVIVAL.


PRACTICAL ASPECTS OF GENETICS FOR PHYSICIANS.


CONTINUING MEDICAL EDUCATION. AMA INTERESTS IN COORDINATION.


CONTINUING MEDICAL EDUCATION. ATTITUDES AND ACTIVITIES IN SCHOOLS OF MEDICINE.


MENINGOCOCCAL INFECTIONS. FORT ORD AND CALIFORNIA. Meningococcal meningitis began to occur in outbreak proportions during 1962 at Fort Ord, Monterey County. This increase in incidence continued until basic training was stopped at that post late in 1964. Most of the cases were among basic trainees in the first eight weeks of training, although other personnel had close contacts with trainees. All of the meningococci isolated were serotype B and about 50 per cent of the military patients with meningitis had sulfadiazine resistant strains. At this time, approximately 20 per cent of the civilian male population of military age are carriers of the organism before going into service. By eight weeks of training nearly 90 per cent of the men in some barracks carried the organism. Yet there was no correlation between the carrier rate and the occurrence of cases between barracks.A feature of this outbreak was that a high proportion of healthy males (20 per cent) were carriers of type B meningococci. This finding reflects the carrier rate in the general civilian population of the same age. The organism is apparently so widely disseminated throughout the population that it is impossible to decide with certainty the source of the organism infecting any particular person. It is unlikely that military groups pose extraordinary hazard to civilians. During 1964, only one case of meningococcal meningitis was found among the civilians of Monterey County while there were 89 in military personnel and 10 among the civilian dependents of military personnel. At present there is an increasing rate of meningococcal meningitis among the total population of California, suggesting that this area is on the upward swing in the cyclical occurrence of the disease.


FOUR HUNDRED AND FIFTY CONSECUTIVE OPEN HEART OPERATIONS. Four hundred and fifty consecutive open heart operations on 437 patients, using cardiopulmonary by-pass, were done at the Stanford Medical Center from January 8, 1960, to July 15, 1964. The in-hospital mortality was 6.4 per cent. Of the patients who survived, 18.4 per cent had a major complication. In 57 per cent of the cases the lesions were congenital, in 42 per cent acquired, and in 1 per cent both congenital and acquired.The correction of nearly all intracardiac and serious vascular defects is now possible with the use of extracorporeal circulation. The mortality and morbidity rates are low enough so that every person with a cardiovascular defect should be seriously considered for surgical correction.


PARADOXES OF TAKAYASU'S DISEASE.

PARADOXES OF TAKAYASU'S DISEASE. Takayasu's disease (or arteritis) has been defined as an "idiopathic aortitis usually affecting young women." It can come to light from very spectacular and often quite puzzling clinical manifestations. Six cases of Takayasu's disease were investigated at the UCLA Hospital in the years 1961-1962, and signs and symptoms of central nervous system involvement were found in five of the patients. This relatively high incidence of neurological deficit prompted a review of case reports in the literature and this in turn led to a series of "unexpected" findings in the historical evolution of the illness as well as in its anatomopathological aspects. The study indicated that Takayasu's disease is frequently associated with neurological manifestations, at times very severe. In addition, the disease appears to be far more extensive than its classical description suggests. New criteria for the diagnosis of Takayasu's disease must include, among other things, special emphasis on the disseminated nature of the disease.


THYROID OPERATIONS. A REVIEW OF 364 CONSECUTIVE CASES. Three hundred sixty-four operations on the thyroid gland done in a five year period (1956-1961) in two private suburban Los Angeles Hospitals were reviewed. Two hundred twenty-three of the operations were done for the treatment of solitary nodular goiter (clinical diagnosis). Twenty-three cancers were found, an incidence of 10.5 per cent. Only one cancer was definitely diagnosed preoperatively. Multinodular non-toxic goiters were diagnosed clinically in 39 cases and two cancers were present. Cancer was not found in the 23 cases of nodular toxic goiter.Graves' disease was treated surgically in 35 cases, or almost 10 per cent of the total series. In four the microscopic appearance of Hashimoto's thyroiditis was present. Thyroiditis was diagnosed by the pathologist in 51 instances, or about 14 per cent of the series. It was Hashimoto's thyroiditis in 40 cases. Three cancers were found associated with Hashimoto's thyroiditis. There was nothing definitely diagnostic about the protein-bound iodine test or the I(131) uptake test or scan in nodular goiter, thyroiditis or cancer. Cancer was found in six "cold" nodules, in one hypofunctioning nodule and in one "warm" nodule. Cancer was not found in any cases clinically diagnosed as toxic nodular goiter. The clinical accuracy of the preoperative diagnosis was 70 per cent for solitary nodular goiter and 90 per cent for multinodular goiter. Only three cases of Hashimoto's thyroiditis were definitely diagnosed preoperatively. Needle biopsy was not done.Eighty-six per cent of the cancers were papillary, mixed or follicular; 14 per cent were anaplastic. In 24 per cent of the cases of cancer there was local invasion or metastasis to lymph nodes, lung or bone by the time operation was done.


USE OF ILEAC SEGMENT CONDUITS IN UROLOGICAL OPERATIONS. The cases of 50 patients in whom ileac segments were utilized in urological operations were reviewed. The complications were more prevalent in patients with malignant disease. The results were particularly gratifying in children with neurogenic vesical dysfunction. Evisceration was the most common of the serious immediate complications. The results were as good in cases in which the ureters were not "splinted" as they were when splinting catheters were used. Four deaths were recorded during the hospital stay. Overall, the procedure was thought to be satisfactory in the management of otherwise serious, and often hopeless, urologic problems.


EMULSION THERAPY FOR ALLERGIC DISEASE. CLINICAL RESULTS WITH USE OF SMALL VOLUMES. In a series of cases in which emulsion repository desensitization therapy for allergic disease was carried out, the amount of emulsion injected was, for a time, one milliliter. Then, for a second period, the volume was reduced to 0.5 milliliter, and minor refinements of technique were introduced. Many of the patients treated in the first period were also treated in the second. The incidence of untoward reaction, ranging from mild soreness to the development of draining cysts at the site of injection into the arm, was greatly reduced between the first and second periods.


EDWARD ROBESON TAYLOR, M.D.

EDWARD ROBESON TAYLOR, M.D.


A NEW PHYSICAL SIGN FOR THE DETECTION OF SMALL PLEURAL EFFUSIONS.


EFFECTIVE PSYCHOPHARMACOLOGY.

EFFECTIVE PSYCHOPHARMACOLOGY.


MANAGEMENT OF ATOPIC DERMATITIS.

MANAGEMENT OF ATOPIC DERMATITIS. Fourteen patients with severe atopic dermatitis of long duration, requiring long term systemic corticosteroid therapy were managed with a treatment program designed to preserve the natural lipid surface film, avoid controllable stimuli to sweating, control skin infection, modify existing keratoderma and utilize active topical corticosteroid therapy in non-lipid vehicles. Substantial healing of the skin occurred in all cases even with discontinuance of systemic administration of steroids.


RUPTURE OF THE NORMAL SPLEEN AND CANCER OF THE PANCREAS.


THROMBOTIC THROMBOCYTOPENIC PURPURA ASSOCIATION WITH METASTATIC GASTRIC CARCINOMA AND A POSSIBLE AUTO-IMMUNE DISORDER.


STAFFING EMERGENCY UNITS IN HOSPITALS.

STAFFING EMERGENCY UNITS IN HOSPITALS.


ENDOTOXIN SHOCK WITH MASSIVE ADRENAL HEMORRHAGE.


WORKMEN'S COMPENSATION LAW . ADMINISTRATION AND PROVISIONS IN CALIFORNIA, 1964.


HISTOPATHOLOGY OF URINARY BLADDER TUMORS INDUCED BY BOVINE CUTANEOUS PAPILLOMA AGENT.


FURTHER OBSERVATIONS ON LATE SOMATIC EFFECTS OF RADIOMIMETIC CHEMICALS AND X-RAYS IN MICE.


IMMUNOLOGICAL STUDIES WITH THE USE OF NUTRITIONAL VARIANTS OF SARCOMA 180.


MECHANISM OF LIVER CATALASE DEPRESSION IN TUMOR-BEARING ANIMALS: A REVIEW.


THE INCIDENCE OF PATHOLOGIC ABNORMALITIES, INCLUDING SPONTANEOUS LYMPHOSARCOMAS, IN A LABORATORY STOCK OF XENOPUS (THE SOUTH AFRICAN CLAWED TOAD).


METABOLISM OF PURINE NUCLEOSIDE ANALOGS.


THE RELATIONSHIP OF CHRONIC ULCERATION OF THE ILEOCECAL JUNCTION TO THE DEVELOPMENT OF RETICULOENDOTHELIAL TUMORS IN C3H MICE.


RAT LIVER PARENCHYMAL CELL FUNCTION DURING AZO DYE CARCINOGENESIS.


FURTHER ASPECTS OF LYMPHOSARCOMA IN XENOPUS (THE SOUTH AFRICAN CLAWED TOAD).


BIBLIOGRAPHY OF DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. BOOKS AND ARTICLES RECEIVED IN 1964.


UTILIZATION OF THE SARAFOFF OPERATION FOR PROCIDENTIA AND PROLAPSE.


MANAGEMENT OF GASTROINTESTINAL FISTULAS.


INTESTINAL ANTISEPSIS.

INTESTINAL ANTISEPSIS.


VOLVULUS OF THE SIGMOID FLEXURE.

VOLVULUS OF THE SIGMOID FLEXURE.


REGIONAL ENTEROCOLITIS.

REGIONAL ENTEROCOLITIS.


RESTORATION AND MAINTENANCE OF METABOLIC BALANCE DURING THE PREOPERATIVE AND POSTOPERATIVE PHASES BY ARTIFICIAL FEEDING IN THE DEBILITATED PATIENT.


SURGICAL CARE OF MASSIVE RECTAL PROLAPSE.


EFFECT OF MORPHINE ON DIVERTICULA OF THE COLON.


PROLONGED EFFECTS OF LSD ON EEG RECORDS DURING DISCRIMINATIVE PERFORMANCE IN CAT; EVALUATION BY COMPUTER ANALYSIS.


THE TONIC CONTROL OF CORTICAL RESPONSIVENESS BY INHIBITORY AND FACILITATORY DIFFUSE INFLUENCES.


SIGMOIDAL MYOTOMY FOR ACUTE DIVERTICULITIS.


AN ELECTROGRAPHIC STUDY OF THE HIPPOCAMPUS AND NEOCORTEX IN UNRESTRAINED RATS FOLLOWING SEPTAL LESIONS.


SIGMOIDOVAGINAL FISTULA COMPLICATING SIGMOIDAL DIVERTICULITIS: REPORT OF TWO CASES.


INTESTINAL NEOPLASIA IN DOMESTIC PETS.

INTESTINAL NEOPLASIA IN DOMESTIC PETS.


FREQUENCY SPECIFIC MECHANISMS IN LEARNING. I. OCCIPITAL ACTIVITY DURING SENSORY PRECONDITIONING.


THE EEG EFFECTS OF COMBINED HYPERVENTILATION AND HYPOXIA IN NORMAL SUBJECTS.


AUDITORY EVOKED RESPONSES DURING DIFFERENT STAGES OF SLEEP IN MAN.


COLOSTOMY PERFORATIONS BY THE IRRIGATING TIP.


ANAL FASCIITIS.

ANAL FASCIITIS.


INFECTIOUS SYPHILIS OF THE RECTUM: REPORT OF A CASE.


CONSTRUCTION OF AN ARTIFICIAL VAGINA, UTILIZING THE SIGMOID FLEXURE, IN CONGENITAL APLASIA VAGINAE.


A SPIKE INTENSIFIER AND SINGLE TRIGGER GENERATOR FOR IDENTIFICATION OF VENTRAL ROOT AXONS.


THE RECTORESECTOR: A NEW INSTRUMENT FOR RESECTION OF THE RECTUM AND COLORECTAL ANASTOMOSIS WITHOUT SUTURES.


VERTIGO AND THE ELECTROENCEPHALOGRAM.

VERTIGO AND THE ELECTROENCEPHALOGRAM.


PERIANAL RHABDOMYOSARCOMA IN  AN INFANT.

PERIANAL RHABDOMYOSARCOMA IN  AN INFANT.


SPECTRUM ANALYZER FOR EEG.

SPECTRUM ANALYZER FOR EEG.


PATHOGNOMONIC TRIAD OF RETRORECTAL ABSCESS: THE SURGICAL APPROACH.


REMOVAL OF GLASS FOREIGN BODIES FROM THE RECTUM BY WIRE SNARE.


ELECTRO-CLINICAL CORRELATIONS IN THE SIX PER SECOND SPIKE AND WAVE COMPLEX.


PERIANAL CYSTS RELATED TO ANAL DUCTS.

PERIANAL CYSTS RELATED TO ANAL DUCTS.


DIFFERENTIAL DIAGNOSIS OF HEMORRHOIDS.

DIFFERENTIAL DIAGNOSIS OF HEMORRHOIDS.


SMALL POLYPOID LESIONS ASSOCIATED WITH SPASTIC DIVERTICULOSIS.


PROGRESS OF A MARKER IN THE LARGE INTESTINE.


RHYTHMIC FIRING IN THE SPONTANEOUS ACTIVITY OF CENTRALLY LOCATED NEURONS. A METHOD OF ANALYSIS.


CRYOGENIC PROBE FOR SMALL SUBCORTICAL LESIONS.


EXCITABILITY CYCLES OF DIFFERENT GYRI OF CAT CORTEX.


EFFECTS OF STIMULUS COMPLEXITY AND INCONGRUITY ON DURATION OF EEG DESYNCHRONIZATION.


EXCITABILITY CYCLE OF THE DIRECT CORTICAL RESPONSE STUDIED WITH MINIMAL STIMULI AND RESPONSE AVERAGING.


PATTERNS OF EXCITABILITY IN THE CAT CEREBRAL CORTEX.


CORTICAL AND SUBCORTICAL EVOKED RESPONSES TO CENTRAL STIMULI DURING WAKEFULNESS AND SLEEP.


A NEW CONCEPT OF MECHANISM AND TREATMENT OF RECTAL PROCIDENTIA.


AVERAGED EVOKED POTENTIALS AND CHOLINERGIC SYNAPSES IN THE SOMATOSENSORY CORTEX OF THE CAT.


ELECTROENCEPHALOGRAPHIC MONITORING DURING RECONSTRUCTIVE SURGERY OF THE NECK VESSELS.


EEG PATTERNS INDUCED BY INTRACAROTID INJECTION OF SODIUM AMYTAL.


ELECTROENCEPHALOGRAPHIC CHANGES INDUCED BY STIMULATION OF THE CEREBELLUM OF MAN.


A ROLLING DIAPHRAGM HYDRAULIC MICRO-MANIPULATOR.


A METHOD OF RECORDING SINGLE CELL DISCHARGES IN THE CEREBRAL CORTEX OF MAN.


APPLICATION OF THE EXPONENTIAL TIME-BASE IN RECORDING OF EVOKED RESPONSES IN MAN.


THE REAL-TIME SORTING OF NEURO-ELECTRIC ACTION POTENTIALS IN MULTIPLE UNIT STUDIES.


DIGITAL COVERTER SYSTEM FOR ELECTROENCEPHALOGRAPHIC RECORDS MADE UP FROM LABORATORY INSTRUMENTS.


EXPERIMENTAL ENHANCEMENT OF ALPHA ACTIVITY.


COMPARISON OF SUBCORTICAL, CORTICAL AND SCALP ACTIVITY USING CHRONICALLY INDWELLING ELECTRODES IN MAN.


BEHAVIORAL, UNIT AND SLOW POTENTIAL CHANGES IN METHIONINE SULFOXIMINE SEIZURES.


COMPARATIVE THRESHOLDS OF CORTEX, VESTIBULAR SYSTEM AND RETICULAR FORMATION IN WAKEFULNESS, SLEEP AND RAPID EYE MOVEMENT PERIODS.


ELECTROENCEPHALOGRAPHIC STUDY ON NARCOLEPSY.


SOME OBSERVATIONS ON THE HUMAN RHINENCEPHALON. A STEREO-ELECTROENCEPHALOGRAPHIC STUDY.


CONTINGENT ALPHA BLOCKING: CONDITIONING OR SENSITIZATION?


THE ELECTROENCEPHALOGRAM IN CEREBRAL FAT EMBOLISM.


ELECTROENCEPHALOGRAPHIC STUDIES ON A NEW LONG LASTING CONVULSANT DRUG: TROPYL-CHROMONE-2-CARBOXYLATE HYDROCHLORIDE.


A NEUROPHYSIOLOGICAL COMPARISON OF GAMMA-HYDROXYBUTYRATE WITH PENTOBARBITAL IN CATS.


COMPUTER-BASED METHODOLOGY FOR SYSTEM DEVELOPMENT: SITE PRODUCTION AND REDUCTION SYSTEM.


MEASUREMENT OF ANALOG SEQUENTIAL DEPENDENCIES.


OUTLINE OF A PROPOSED PROGRAM FOR DEVELOPMENT OF A MEDICAL CENTER FOR KAPIOLANI MATERNITY & GYNECOLOGICAL HOSPITAL, KAUIKEOLANI CHILDREN'S HOSPITAL, AND THE QUEEN'S HOSPITAL, HONOLULU.


SUBJECTIVE INFORMATION AS A FUNCTION OF SOURCE INFORMATION.


TROUBLESHOOTING PERFORMANCE AS A FUNCTION OF PRESENTATION TECHNIQUE AND EQUIPMENT CHARACTERISTICS.


EFFECTS OF INSTRUCTIONS ON WIRING TASK ACCOMPLISHMENT.


CRITERIA FOR HUMAN PERFORMANCE RESEARCH.


THE DEI TECHNIQUE FOR EVALUATING EQUIPMENT SYSTEMS FROM THE INFORMATION TRANSFER POINT OF VIEW.


BINARY CHOICE IN A DYNAMIC ENVIRONMENT.

BINARY CHOICE IN A DYNAMIC ENVIRONMENT.


PLANNING FOR HOSPITAL AND RELATED HEALTH FACILITIES AND SERVICES.


LEVELS OF PRACTICE, LEARNING CURVES, AND SYSTEM VALUES FOR HUMAN PERFORMANCE ON COMPLEX TASKS.


PROBLEMS IN EVALUATING SYSTEM MANNING REQUIREMENTS ESTIMATES AND ESTIMATION TECHNIQUES.


INFANT DEATH STUDY.

INFANT DEATH STUDY.


INSTITUTE ON THE CARE OF PREMATURE INFANTS. INTRODUCTION TO THE INSTITUTE.


THE EFFECT OF FLASH DISTRIBUTION AND ILLUMINATION LEVEL UPON THE DETECTION OF LOW INTENSITY LIGHT STIMULI.


NUTRITION OF THE PREMATURE INFANT.

NUTRITION OF THE PREMATURE INFANT.


INFECTIONS IN THE NEWBORN.

INFECTIONS IN THE NEWBORN.


PROGRESS IN ALLERGY. 3.

PROGRESS IN ALLERGY. 3.


ADENOCARCINOMA OF THE APPENDIX. REPORT OF TWO CASES.


SPONTANEOUS RUPTURE OF THE SPLEEN WITH SUBACUTE BACTERIAL ENDOCARDITIS.


TRENDS TOWARD GOVERNMENT MEDICINE IN CANADA.


RESPIRATORY DISTRESS SYNDROME OF THE NEWBORN. A RETROSPECTIVE STUDY OF 100 CASES.


ENFORCEMENT OF THE MEDICAL PRACTICE ACT.


PERSONAL EXPERIENCE WITH STAPEDECTOMIES.


CARCINOMA OF THE LIP.

CARCINOMA OF THE LIP.


ECTOPIC PREGNANCY--SYMPTOMS AND DIAGNOSIS.


FUNDAMENTALS OF BACTERIAL ALLERGY AND IMMUNOLOGICAL EVIDENCE OF ITS ROLE IN THE ETIOLOGY OF ASTHMA.


A STUDY OF BLASTOMYCOSIS IN ARKANSAS.

A STUDY OF BLASTOMYCOSIS IN ARKANSAS.


THE IMPORTANCE OF SULFUR IN BIOLOGICAL SYSTEMS AS DETERMINED BY ESR STUDIES.


CYTOGENETICS IN CLINICAL PRACTICE.

CYTOGENETICS IN CLINICAL PRACTICE.


A COMPARATIVE STUDY OF LIDOCAINE AND MEPIVACAINE FOR SPINAL ANESTHESIA.


CASE REPORT XI OF MATERNAL MORTALITY STUDY: RUPTURED ECTOPIC PREGNANCY.


UNCLASSIFIED MYCOBACTERIA IN MISSISSIPPI.


ESOPHAGEAL HIATAL HERNIA.

ESOPHAGEAL HIATAL HERNIA.


RADIOLOGIC SEMINAR XXXV: REDUCTION OF ILEO-COLIC INTUSSUSCEPTION.


THE REPLICATION OF BACTERIOPHAGE MS2. 3. ASYMMETRIC COMPLEMENTATION BETWEEN TEMPERATURE-SENSITIVE MUTANTS.


RNA NUCLEOTIDE SEQUENCE CLUSTERS OF NORMAL AND ROUS SARCOMA VIRUS-INFECTED TISSUES.


SELECTIVE IN VITRO INHIBITION BY RNA OF DNA-DEPENDENT AMINO ACID INCORPORATION INTO PROTEIN.


TEMPLATE AND RIBOSOMAL RIBONUCLEIC ACIDS ASSOCIATED WITH THE CHLOROPLASTS AND THE CYTOPLASM OF EUGLENA GRACILIS.


AMINO GROUP REACTIVITY IN DNA--AMINOACRIDINE COMPLEXES.


A MUTANT ENZYME IN NEUROSPORA CRASSA INTERCONVERTIBLE BETWEEN ELECTROPHORETICALLY DISTINCT ACTIVE AND INACTIVE FORMS.


INFECTIVITY OF DNA ISOLATED FROM BACILLUS SUBTILIS BACTERIOPHAGE, SP82.


THE REPLICATION AND COATING OF VACCINIA DNA.


THE EFFECT OF RADIOPHOSPHORUS DECAY ON CISTRON FUNCTION IN BACTERIOPHAGE T4. I. LONG-RANGE AND SHORT-RANGE HITS.


REPLICATION OF BACTERIOPHAGE RNA: STUDIES ON THE FATE OF PARENTAL RNA.


DETERMINATION OF THE KAPPA-HELIX CONFIGURATION OF POLY-GAMMA-BENZYL-L-GLUTAMATE BY ELECTRON DIFFRACTION.


SOME ABNORMAL PROPERTIES OF CHLORAMPHENICOL RNA.


LATE RESULTS OF THROMBENDARTERECTOMY IN OBLITERATIVE ATHEROSCLEROSIS.


ELECTRON SPIN RESONANCE SPECTROSCOPY.

ELECTRON SPIN RESONANCE SPECTROSCOPY.


INTER- AND INTRASUBJECT VARIATIONS IN DRUG ABSORPTION KINETICS.


METAL-ACID COMPLEXES WITH MEMBERS OF THE TETRACYCLINE FAMILY. I. INTRODUCTION.


ANALOGS OF TETRAHYDROFOLIC ACID. XV. MODE OF BINDING OF 2,4-DIAMINOPYRIMIDINES TO FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE.


OXIDATION OF ALDEHYDES SOLUBILIZED IN NONIONIC SURFACTANTS. I. SOLUBILITY OF BENZALDEHYDE AND METHYLBENZALDEHYDE IN AQUEOUS SOLUTIONS OF POLYOXYETHYLENE GLYCOL ETHERS.


EFFECT OF COMPLEX FORMATION ON DRUG ABSORPTION. I. COMPLEXES OF SALICYLIC ACID WITH ABSORBABLE AND NONABSORBABLE COMPOUNDS.


EFFECT OF CERTAIN DRUGS ON PERFUSED HUMAN PLACENTA. IV. DETECTION OF SPECIFIC RECEPTOR SITES.


CARDIAC EFFECTS OF ANGIOTENSIN. II.

CARDIAC EFFECTS OF ANGIOTENSIN. II.


ASPIRIN FORMULATION AND ABSORPTION RATE. I. CRITERIA FOR SERUM MEASUREMENTS WITH HUMAN PANELS.


ASPIRIN FORMULATION AND ABSORPTION RATE. II. INFLUENCE ON SERUM LEVELS OF TABLETS, ANTACIDS, AND SOLUTIONS.


ISOLATION OF COUMESTROL AND OTHER PHENOLICS FROM ALFALFA BY COUNTERCURRENT DISTRIBUTION.


SYNTHESIS OF SOME HEXAMINE DERIVATIVES AS POTENTIAL ANTISPASMODICS.


CHROMATOGRAPHIC INVESTIGATION OF THE ESSENTIAL OIL OF ACHILLEA FRAGRANTISSIMA.


CONSTITUTION OF MAMEY WAX.

CONSTITUTION OF MAMEY WAX.


ENZYME INHIBITORS. 3. SYNTHESES OF CIS-(6-SUBSTITUTED-9-PURINYL)CYCLOALKYLCARBINOLS AS ADENOSINE DEAMINASE INHIBITORS.


STEROL METABOLISM IN LARVAE OF THE CONFUSED FLOUR BEETLE, TRIBOLIUM CONFUSUM.


SYNTHETIC POLYMERS AS POTENTIAL SUSTAINED-RELEASE COATINGS.


QUALITATIVE AND QUANTITATIVE TESTS FOR METAXALONE.


NEW PREPARATIVE TECHNIQUE FOR EFFERVESCENT PRODUCTS.


TABLET ACCEPTANCE BY A DOUBLE SAMPLING PLAN.


INFLUENCE OF PHYSOSTIGMINE AND NEOSTIGMINE ON THE RESPONSES OF GOLDFISH INTESTINE TO ACETYLCHOLINE.


METAL-ACID COMPLEXES WITH MEMBERS OF THE TETRACYCLINE FAMILY. II. DEVELOPMENT OF STABLE PRECONSTITUTED PARENTERAL FORMULATIONS.


CONVENIENT SYNTHESIS OF N,N,N'-TRISUBSTITUTED FORMAMIDINES.


COUMARINS. 3. IDENTIFICATION OF THE LACTONE OF LEPTOTAENIA MULTIFIDA.


SOME PHARMACOLOGICAL PROPERTIES OF POLYMYXIN B SULFATE.


REDUCTION OF BARBITURATES UNDER HYDROBORATION CONDITIONS.


METHOD FOR STERILITY TESTING OF OILS.

METHOD FOR STERILITY TESTING OF OILS.


POTENTIAL ANTIRADIATION COMPOUNDS. II. EXTENSION OF THE NITRO-THIOLACETATE ROUTE.


OPIUM ALKALOIDS--SEPARATION AND IDENTIFICATION BY GAS, THIN-LAYER, AND PAPER CHROMATOGRAPHY.


USE OF HAMMETT GRAPHS IN STABILITY PROGRAMS.


IDENTIFICATION OF 3',4',7-TRIHYDROXYFLAVONE IN LADINO CLOVER.


DETERMINATION OF ANHYDROTETRACYCLINE AND 4-EPIANHYDROTETRACYCLINE IN A TETRACYCLINE MIXTURE.


INFRARED ABSORPTION RATIO METHOD FOR DETERMINATION OF TRIETHANOLAMINE SALICYLATE IN OINTMENT.


MANNICH BASES AND ALCOHOLS FROM HEXAMETHYLENIMINE.


PERICYCLIVINE, A NEW CATHARANTHUS ALKALOID.


A CORRELATION OF THE EFFECTS OF CERVICAL CORDOTOMY, HYPOTHERMIA AND CATECHOLAMINES ON CARBON TETRACHLORIDE-INDUCED HEPATIC NECROSIS.


THE DISTRIBUTION AND FATE OF D-TUBOCURARINE.


MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.


VITAMIN K-LIKE AND ANTIVITAMINE K ACTIVITY OF SUBSTITUTED PARA-BENZOQUINONES.


IN VIVO GENERATION OF H2O2 IN MOUSE ERYTHROCYTES BY HEMOLYTIC AGENTS.


EFFECTS OF LOCAL ANESTHETICS ON SODIUM AND POTASSIUM IN HUMAN RED CELLS.


RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID: A PHENOXYACETIC SALURETIC-DIURETIC AGENT.


MECHANISM OF EPINEPHRINE INHIBITION OF THE MILK EJECTING RESPONSE TO OXYTOCIN.


THE CARDIOVASCULAR EFFECTS OF N-(GAMMA-METHYLAMINOPROPYL-IMINO-DIBENZYL)-HCL (DESMETHYLIMIPRAMINE) AND GUANETHIDINE.


CONTRACTILITY, HEART RATE, AND RESPONSE TO NOREPINEPHRINE OF ISOLATED RAT MYOCARDIUM FOLLOWING I-131-INDUCED HYPOTHYROIDISM.


INOTROPIC AND CHRONOTROPIC EFFECTS OF DICHLOROISOPROTERENOL ON RAT ATRIA.


COMPARISON OF EFFECTS OF AROMATIC SYMPATHOMIMETIC AMINES ON RABBIT AORTIC STRIP AND RABBIT BLOOD PRESSURE.


BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS  BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.


THE SURGERY OF TRAUMA--THEN AND NOW.

THE SURGERY OF TRAUMA--THEN AND NOW.


EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE.


AIR BLAST INJURIES. REPORT OF A CASE.

AIR BLAST INJURIES. REPORT OF A CASE.


COMMUNITY DISASTER PLANNING.

COMMUNITY DISASTER PLANNING.


THE USE OF DRUGS IN THE TREATMENT OF IRREVERSIBLE VASOCONSTRICTOR SHOCK.


SURGICAL CORRECTION OF INJURIES OF THE VENA CAVA: AN ANALYSIS OF SIXTY-ONE CASES.


NEUROPLEGICS IN THE TREATMENT OF BURNS: EXPERIMENTAL AND CLINICAL RESULTS.


A FIVE-YEAR SURVEY OF 152 ACUTE ABDOMINAL INJURIES.


AN OBJECTIVE EVALUATION OF THE SPREADING ENZYMES IN THE TREATMENT OF EXPERIMENTALLY PRODUCED LYMPHEDEMA.


VASCULAR DESTRUCTIVE EFFECTS OF THERMAL INJURY AND ITS RELATIONSHIP TO BURN WOUND SEPSIS.


SURGICAL EXPERIENCE WITH 103 TRUNCAL SHOTGUN WOUNDS.


THE ROLE OF THE RED CELL IN SUBCUTANEOUS INFECTION.


THE POSSIBLE RELATIONSHIP OF CERTAIN CHROMATOGRAPHIC CHANGES TO COAGULATION ABERRATIONS IN HYPOTENSIVE PATIENTS: A PRELIMINARY REPORT.


CHANGES OF CATECHOLAMINES AFTER COMPLETE CARDIAC SYMPATHECTOMY.


DISTRIBUTION OF CARDIAC SYMPATHETIC NERVES.


THE RATE OF RESPIRATION AND INCORPORATION OF P32 INTO ADENOSINE TRIPHOSPHATE BY RAT AORTA TISSUE.


CHEMICAL EVALUATION OF THE DISTRIBUTION OF CATECHOLAMINES IN THE HEART.


PROSPECT AND PRACTICE IN CHILD HEALTH.

PROSPECT AND PRACTICE IN CHILD HEALTH.


AORTOGRAPHY IN THE INVESTIGATION OF HYPERTENSION.


HOMOGRAFT SENSITIVITY REACTIONS IN IRRADIATED HAMSTERS.


DIFFERENTIAL URETHROVESICAL URINARY CELL-COUNT. A METHOD OF ACCURATE DIAGNOSIS OF LOWER-URINARY-TRACT INFECTIONS IN WOMEN.


BIOCHEMICAL AND FLUORESCENCE-MICROSCOPY SCREENING-TESTS FOR ERYTHROPOIETIC PROTOPORPHYRIA.


DEVICE FOR THE STABILISATION OF ANTERIOR CHEST-WALL INJURIES.


THE VACUUM EXTRACTOR: A POSSIBLE DANGER.


AN UNUSUAL COMPLICATION OF VACUUM EXTRACTION.


CEREBRAL COLLAPSE ASSOCIATED WITH CHRONIC SUBDURAL HAEMATOMA IN ADULTS: A COMPARISON OF TWO METHODS OF TREATMENT.


POSTOPERATIVE WOUND INFECTION.

POSTOPERATIVE WOUND INFECTION.


TESTING OF SENSITIVITY TO ANTIBIOTICS.

TESTING OF SENSITIVITY TO ANTIBIOTICS.


CONTROL OF HYPOGLYCAEMIA WITH DIAZOXIDE AND HUMAN GROWTH HORMONE.


HYPOTHYROIDISM AFTER TREATMENT OF THYROTOXICOSIS WITH RADIOIODINE.


PERSISTENT ORAL DYSKINESIA IN TREATMENT WITH PHENOTHIAZINE DERIVATIVES.


ARTERITIS OF THE AORTA AND ITS BRANCHES.


REHABILITATION IN SCHIZOPHRENIA.

REHABILITATION IN SCHIZOPHRENIA.


THE MENTAL HOSPITAL EFFECTS OF AN ALTERNATIVE PSYCHIATRIC SERVICE.


RELATION OF ONSET OF RESPIRATION TO PLACENTAL TRANSFUSION.


FRUSEMIDE.

FRUSEMIDE.


CHROMOSOMAL ENDOREDUPLICATION IN A CASE OF TURNER'S SYNDROME WITH 44/XX KARYOTYPE.


DIETARY FAT AND DIETARY SUGAR.

DIETARY FAT AND DIETARY SUGAR.


CONGENITAL CARDIAC ARRHYTHMIA.

CONGENITAL CARDIAC ARRHYTHMIA.


ELECTROCARDIOGRAPHIC CHANGES ASSOCIATED WITH CEREBROVASCULAR ACCIDENTS.


PULMONARY STENOSIS AND CONGENITAL DEAFNESS.


POSTMORTEM ISOLATION OF RUBELLA VIRUS FROM THREE CHILDREN WITH RUBELLA-SYNDROME DEFECTS.


HYPOGLYCAEMIA INDUCED BY LACTOSE OR GALACTOSE.


LACTASE DEFICIENCY IN ADULTS. A CAUSE OF "FUNCTIONAL" DIARRHOEA.


CLINICAL EVALUATION OF FLUID REQUIREMENTS IN ASIATIC CHOLERA.


EFFECT OF ANTICOAGULANT DRUGS ON PLATELET AGGREGATION IN THE CHANDLER'S TUBE.


EFFECT OF POSTURE ON BLOOD- PRESSURE IN ELDERLY PATIENTS.


BODY COMPOSITION, RESTING OXYGEN CONSUMPTION, AND URINARY CREATININE IN EDINBURGH STUDENTS.


EVALUATION OF SIMULTANEOUS SPLIT-COIL HAEMODIALYSIS WITH THE KOLFF TWIN-COIL ARTIFICIAL KIDNEY.


POLYRADICULONEUROPATHY (GUILLAIN-BARR'E SYNDROME) TREATED WITH 6-MERCAPTOPURINE.


EFFECT OF GASTRIN I AND II ON SECRETION OF INTRINSIC FACTOR.


THE EFFECT OF THAM ON THE OXYGEN TENSION OF ARTERIAL BLOOD IN NEONATAL RESPIRATORY-DISTRESS SYNDROME.


AN AID IN CONTROL OF INTRAVENOUS THERAPY.


A SUGGESTED GENETIC MAP OF INFLUENZA VIRUS.


ILLUMINATED TELESCOPE BIOPSY FORCEPS FOR SIGMOIDOSCOPY OR OESOPHAGOSCOPY.


HEAVY-CHAIN DISEASE.

HEAVY-CHAIN DISEASE.


HEALTH AND SOCIAL CLASS.

HEALTH AND SOCIAL CLASS.


USE AND ABUSE OF DRUGS.

USE AND ABUSE OF DRUGS.


A PLAGUEY PIPER.

A PLAGUEY PIPER.


RUBELLA VIRUS IN PLACENTA AND FOETUS.

RUBELLA VIRUS IN PLACENTA AND FOETUS.


SPECIALISATION IN ELECTIVE HERNIORRHAPHY.


MISUSE OF SECTION 29--FACT OR FICTION?

MISUSE OF SECTION 29--FACT OR FICTION?


THERAPEUTIC TRIAL OF DIAZEPAM IN TETANUS.


LIVER DYSFUNCTION AND SCHIZOPHRENIA.

LIVER DYSFUNCTION AND SCHIZOPHRENIA.


TREATMENT OF HEPATIC ENCEPHALOPATHY BY ALTERATION OF INTESTINAL FLORA WITH LACTOBACILLUS ACIDOPHILUS.


USE OF MONOAMINE-OXIDASE INHIBITORS.

USE OF MONOAMINE-OXIDASE INHIBITORS.


PULMONARY OEDEMA FOLLOWING DIRECT-CURRENT DEFIBRILLATION.


DRIVER FOR FEMORAL INTRAMEDULLARY NAILS.


ACID-PHOSPHATASE ACTIVITY IN PARTIAL TRANSLOCATION-TRISOMY.


GLUTEN-SENSITIVE ENTEROPATHY AND ECZEMA.


TREATMENT OF PARATYPHOID CARRIER WITH THE SODIUM SALT OF FUSIDIC ACID.


"CRI DU CHAT".

"CRI DU CHAT".


DELETION ON SHORT ARMS OF A B-CHROMOSOME WITHOUT "CRI DU CHAT" SYNDROME.


HAEMODIALYSIS IN THE HAEMOLYTIC-URAEMIC SYNDROME.


REACTION TO CHLORHEXIDINE AND CETRIMIDE.


ANTIBODY-LIKE ACTIVITY IN DIABETIC AND NORMAL SERUM.


PREMALIGNANT LESIONS OF THE COLON AND RECTUM.


NONUNION OF THE SURGICAL NECK OF THE HUMERUS. METHOD OF INTERNAL FIXATION.


THE NATURAL HISTORY OF CHOLELITHIASIS. A 15 TO 30-YEAR FOLLOW-UP OF 116 PATIENTS.


THE LIMPING YOUNG TEENAGER--SLIPPED UPPER FEMORAL EPIPHYSIS.


ACUTE EMPHYSEMATOUS CHOLECYSTITIS.

ACUTE EMPHYSEMATOUS CHOLECYSTITIS.


RESULTS OF CHOLECYSTOSTOMY IN THE TREATMENT OF ACUTE CHOLECYSTITIS.


PAINFUL STUMP NEUROMA--TREATMENT OF.

PAINFUL STUMP NEUROMA--TREATMENT OF.


THE PLACE OF JESUS IN THE HISTORY OF MEDICINE.


THE PARNATE-SPECIFIC PATIENT.

THE PARNATE-SPECIFIC PATIENT.


EATON AGENT PNEUMONIA: CURRENT STATUS.

EATON AGENT PNEUMONIA: CURRENT STATUS.


MENTAL RETARDATION AND HEARING LOSS.

MENTAL RETARDATION AND HEARING LOSS.


INFECTIONS OF THE URINARY TRACT. 3. SYMPTOMATOLOGY.


DIAGNOSTIC RADIOLOGY IN THE COMMUNITY HOSPITAL. DEPARTMENTAL PROBLEMS AND PROCEDURES.


RETROPERITONEAL FIBROSIS SIMULATING CARCINOMA OF THE PANCREAS. REPORT OF A SURGICALLY TREATED CASE COMPLICATED BY FATAL POSTOPERATIVE HEMORRHAGE.


RENOVASCULAR HYPERTENSION.

RENOVASCULAR HYPERTENSION.


TWO HUNDREDTH ANNIVERSARY OF THE UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE.


PROGRESS IN THE MANAGEMENT OF ACUTE CHOLECYSTITIS.


ORAL AGENTS IN CASES OF DIABETES MELLITUS PREVIOUSLY CONTROLLED BY LOW DOSES OF INSULIN.


ACQUIRED CYTOMEGALOVIRUS INFECTION: ASSOCIATION WITH HEPATOMEGALY AND ABNORMAL LIVER-FUNCTION TESTS.


THE POSTPERICARDIOTOMY SYNDROME: A SIX-YEAR EPIDEMIOLOGIC STUDY.


EFFECT OF PROLONGED ETHANOL INGESTION ON THE TRANSPORT AND METABOLISM OF LIPIDS IN MAN.


AN OUTBREAK OF STREPTOCOCCAL PUERPERAL SEPSIS.


PYLOROPLASTY AND VAGOTOMY FOR DUODENAL ULCER: A REVIEW OF A HUNDRED AND TEN CASES.


RECENT ADVANCES IN COMMUNITY PSYCHIATRY.


TREATMENT OF CEREBRAL SWELLING.

TREATMENT OF CEREBRAL SWELLING.


LACTIC ACIDOSIS AND DEATH AFTER THE TREATMENT OF OBESITY BY FASTING.


MUSHROOMS AND A TOXIC REACTION TO ALCOHOL: REPORT OF FOUR CASES.


CRISIS IN GENERAL PRACTICE.

CRISIS IN GENERAL PRACTICE.


THE PLACE OF GEORGE CHEYNE (1673-1743) IN MEDICAL HISTORY.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: CASE 15-1965.


A CENTURY OF SANITARY FAIRS AND HEALTH EXPOSITIONS IN OHIO 1864-1964.


POLYPOID LESIONS OF THE COLON AND RECTUM. A DISCUSSION OF RECOGNITION AND MANAGEMENT.


SMOKING HABITS AND DISEASE IN OHIO.

SMOKING HABITS AND DISEASE IN OHIO.


ACUTE PLASMACYTIC LEUKEMIA WITH HYPERCALCEMIA. REPORT OF A CASE WITHOUT BONE LESIONS.


LATE RESULT OF RENAL INJURY. REPORT OF A CASE.


PULMONARY HYPERTENSION. REPORT OF A CASE IN ASSOCIATION WITH RHEUMATOID ARTHRITIS.


CORRECTABLE RENAL HYPERTENSION. XI. SURGICAL TREATMENT.


A CLINICOPATHOLOGICAL CONFERENCE FROM THE OHIO STATE UNIVERSITY HOSPITAL, COLUMBUS, OHIO.


WHAT IS THE JOB OF THE INDIVIDUAL IN A MASS MEDICAL EMERGENCY.


SPECIAL SESSION ROUNDUP. IMPORTANT ACTIONS TAKEN BY OHIO GENERAL ASSEMBLY DURING MID-WINTER SESSION CALLED BY THE GOVERNOR.


ARTHUR STANLEY HOUSE.

ARTHUR STANLEY HOUSE.


THE UNITED SHEFFIELD HOSPITALS SCHOOL OF PHYSIOTHERAPY.


PLANNING A SCHOOL OF PHYSIOTHERAPY.

PLANNING A SCHOOL OF PHYSIOTHERAPY.


PLANNING A NEW PHYSIOTHERAPY DEPARTMENT: THE WESTMINSTER HOSPITAL.


MIDDLESBROUGH GENERAL HOSPITAL.

MIDDLESBROUGH GENERAL HOSPITAL.


ADDENBROOKE'S HOSPITAL, CAMBRIDGE.

ADDENBROOKE'S HOSPITAL, CAMBRIDGE.


WESTERN GENERAL HOSPITAL, EDINBURGH.

WESTERN GENERAL HOSPITAL, EDINBURGH.


PLANNING A HYDROTHERAPY POOL.

PLANNING A HYDROTHERAPY POOL.


MENSTRUAL DISORDERS OF ADOLESCENCE.

MENSTRUAL DISORDERS OF ADOLESCENCE.


APPENDICITIS SURVEY, USAREUR, 1959 TO 1961.


CHOICE OF OPERATION FOR DUODENAL ULCER.

CHOICE OF OPERATION FOR DUODENAL ULCER.


TREATMENT OF DEPRESSION.

TREATMENT OF DEPRESSION.


PALATAL ABNORMALITIES IN HEREDITARY DISEASES.


OFFICE CARDIOLOGY IN GENERAL PRACTICE.

OFFICE CARDIOLOGY IN GENERAL PRACTICE.


THE VALUE OF COUGH REMEDIES.

THE VALUE OF COUGH REMEDIES.


ATYPICAL ANGINA PECTORIS: DIAGNOSTIC ADVANCES.


ULTRAVIOLET LIGHT IN OFFICE PRACTICE.

ULTRAVIOLET LIGHT IN OFFICE PRACTICE.


THE ICHTHYOSIFORM GENODERMATOSES.

THE ICHTHYOSIFORM GENODERMATOSES.


CONTACT DERMATITIS: DIAGNOSIS AND TREATMENT.


INSECT STINGS AND BITES: DIAGNOSIS, TREATMENT AND PREVENTION.


THERAPY OF MELANIN HYPERPIGMENTATION.

THERAPY OF MELANIN HYPERPIGMENTATION.


STAPHYLOCOCCAL SKIN INFECTIONS: TREATMENT OF IMPETIGO AND OF ACUTE AND CHRONIC FURUNCULOSIS.


PROGRESSIVE EVALUATION OF THE NEWBORN INFANT.


GYNECOLOGIC PROBLEMS OF AGING.

GYNECOLOGIC PROBLEMS OF AGING.


PRACTICAL TESTS OF PLACENTAL FUNCTION.

PRACTICAL TESTS OF PLACENTAL FUNCTION.


PERITONEAL DIALYSIS: INDWELLING CANNULA PERMITS INTERMITTENT DIALYSIS WITHOUT REPEATED PARACENTESIS.


ELECTROCARDIOGRAPHIC MANIFESTATIONS OF HYPERCALCEMIA.


THE CLINICAL APPLICATION OF PERITONEAL DIALYSIS.


NUTRITIONAL PROBLEMS WITH MALIGNANT DISEASES. 1. SYSTEMIC AND LOCALIZED EFFECTS OF MALIGNANCIES.


HODGKIN'S DISEASE AND PULMONARY INFLITRATIONS.


STROKES. 1. SOME LITERARY DESCRIPTIONS.

STROKES. 1. SOME LITERARY DESCRIPTIONS.


VENEREAL DISEASE EXHIBIT AT TEENAGE FAIR.


MORTALITY AND GEOGRAPHIC DISTRIBUTION OF ARTERIOSCLEROTIC HEART DISEASE.


FLUORIDATION OF WATER SUPPLIES IN SMALL RURAL COMMUNITIES.


THE APPLICATION OF COMPUTER GRAPHICS TO PATIENT ORIGIN STUDY TECHNIQUES.


EXPERIENCES OF PUBLIC HEALTH NURSES IN OBTAINING FAMILY PEDIGREES.


SCREENING FOR VISUAL IMPAIRMENT.

SCREENING FOR VISUAL IMPAIRMENT.


THE AREA ADJUSTED MAP. AN EPIDEMIOLOGIC DEVICE.


INACTIVATED MEASLES-VIRUS VACCINE.

INACTIVATED MEASLES-VIRUS VACCINE.


MEASLES-NEUTRALIZING AND HI ANTIBODY TITERS OF HUMAN GAMMA GLOBULIN PREPARATIONS.


DEMOGRAPHIC ASPECTS IN SELECTING A SITE FOR A COMMUNITY EPIDEMIOLOGIC STUDY.


TRAINING IN CARDIOPULMONARY RESUSCITATION.


SURVEY OF RADIUM SOURCES IN OFFICES OF PRIVATE PHYSICIANS.


NEED OF A CLASSIFICATION SCHEME FOR THE PSYCHOSOCIAL DISORDERS.


SURVEY OF TUBERCULOSIS INFORMATION AMONG MADISON ADULTS.


SHORT-TERM MEMORY FOR REPEATED AND NON-REPEATED ITEMS.


ADAPTATION AND REPULSION IN THE FIGURAL AFTER-EFFECT.


AUTOMATIC PITCH DISCRIMINATION TESTING AND RECORDING DEVICE.


OVERTRAINING, TRANSFER TO PROPRIOCEPTIVE CONTROL AND POSITION REVERSAL.


STUDY OF THE SINGLE CHANNEL HYPOTHESIS AND INPUT REGULATION WITHIN A CONTINUOUS, SIMULTANEOUS TASK SITUATION.


VOCALIZATION-AT-PRESENTATION AND IMMEDIATE RECALL, WITH VARYING PRESENTATION-RATES.


SECONDARY REINFORCEMENT VALUE OF STIMULI ASSOCIATED WITH SHOCK REDUCTION.


EFFECT OF EFFORT ON RESISTANCE TO EXTINCTION OF THE BAR-PRESSING RESPONSE.


THE INFLUENCE OF STIMULUS SCALE-INTERVAL UPON THE ASSESSMENT OF PAIN THRESHOLD.


COUNTER DISPLACEMENT IN THE VISUAL FIGURAL AFTER-EFFECT.


EXPECTANCY AND INTERMITTENCY.

EXPECTANCY AND INTERMITTENCY.


A DISPLAY UNIT FOR COMPUTER GENERATED PATTERNS.


PROBLEMS IN TEACHING PHYSICS TO RADIOGRAPHERS.


PHYSICS IN THE TRAINING OF RADIOGRAPHERS--EXAMINATION STANDARDS.


INTESTINAL OBSTRUCTION AND CARDIAC ARREST IN A LION.


RADIOGRAPHY OF PNEUMATOSIS INTESTINALIS.


NEW JOINTS FOR OLD.

NEW JOINTS FOR OLD.


WESTMINISTER HOSPITAL EXTENSION.

WESTMINISTER HOSPITAL EXTENSION.


PRIMARY LEIOMYOSARCOMATA OF THE LUNG.

PRIMARY LEIOMYOSARCOMATA OF THE LUNG.


CONTROLLED TRIAL OF PROPHYLACTIC PENICILLIN IN THORACIC SURGERY.


NEONATES AND CHEST SURGERY.

NEONATES AND CHEST SURGERY.


PRECIPITIN (F.L.H.) TEST IN FARMER'S LUNG.


DIRECT LEFT VENTRICULOFEMORAL BYPASS DURING RESECTION OF COARCTATION OF THE AORTA WITH AOMALOUS SUBCLAVIAN ARTERIES.


MITRAL INCOMPETENCE AFTER REPAIR OF OSTIUM PRIMUM SEPTAL DEFECTS.


AN UNUSUAL COMPLICATION OF THE TREATMENT OF SPONTANEOUS PNEUMOTHORAX.


INHALED FOREIGN BODIES: SOME COMPLICATIONS AND ERRORS.


LOWER OESOPHAGUS LINED WITH INTESTINAL AND GASTRIC EPITHELIA.


UNEXPLAINED UNDERVENTILATION OF THE LUNGS.


HYPOXAEMIA AFTER PARTIAL GASTRECTOMY.

HYPOXAEMIA AFTER PARTIAL GASTRECTOMY.


AN X-RAY MICROSCOPIC STUDY OF THE VASA VASORUM OF THE NORMAL HUMAN AORTIC ARCH.


THORACIC, THORACO-ABDOMINAL, AND ABDOMINAL DUPLICATION.


TRACHEOSTOMY IN A THORACIC SURGICAL UNIT.


BRONCHIAL CLOSURE.

BRONCHIAL CLOSURE.


STUDIES OF ADRENOCORTICAL FUNCTION IN CONTINUOUS ASTHMA.


THE USE OF A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS (PROTEASE G) IN BLOOD BANKING: A PRELIMINARY ACCOUNT.


THE BLEEDING COMPLICATIONS OF BLOOD TRANSFUSION.


SOMATIC MUTATION AFFECTING THE RHESUS AND DUFFY BLOOD GROUP SYSTEMS.


EFFECT OF PH ON PRESERVATION OF RED CELL ATP.


PRODUCTION OF CHIMPANZEE ISOHEMAGGLUTININS BY IMMUNIZATION WITH HUMAN ERYTHROCYTES.


EFFECT OF RESUSPENSION MEDIUM ON IN VIVO SURVIVAL AND SUPERNATANT HEMOGLOBIN OF ERYTHROCYTES PRESERVED WITH GLYCEROL.


RESPONSE TO TRANSFUSION OF PLATELETS POOLED FROM MULTIPLE DONORS AND THE EFFECTS OF VARIOUS TECHNICS OF CONCENTRATING PLATELETS.


OBSERVATIONS ON RECIPIENT PLASMA HEMOGLOBIN CONCENTRATION AFTER TRANSFUSION WITH GLYCEROLIZED FROZEN BLOOD.


THE V-A-B BLOOD GROUP SYSTEM OF CHIMPANZEES: A PARADOX IN THE APPLICATION OF THE 2 X 2 CONTIGENCY TEST.


IDENTIFICATION OF BLOOD STAINS IN THE IMMUNOHEMATOLOGY LABORATORY: A CASE STUDY.


BLOOD TRANSFUSION IN THE CIVIL WAR.

BLOOD TRANSFUSION IN THE CIVIL WAR.


A FURTHER EXAMPLE OF ANTI-KPA.

A FURTHER EXAMPLE OF ANTI-KPA.


EVALUATION OF BLOOD TRANSFUSION THERAPY.


WORLD SHORTAGE OF MEDICAL MANPOWER.

WORLD SHORTAGE OF MEDICAL MANPOWER.


NOTIFIABLE DISEASES IN THE AMERICAS, 1962.


THE CONTROL OF TUBERCULOSIS.

THE CONTROL OF TUBERCULOSIS.


HEALTH PROBLEMS OF MONGOLIA.

HEALTH PROBLEMS OF MONGOLIA.


PUBLIC HEALTH TRAINING AND RESEARCH.

PUBLIC HEALTH TRAINING AND RESEARCH.


STUDIES ON HYPERURICEMIA. II. A RECONSIDERATION OF THE DISTRIBUTION OF SERUM URIC ACID VALUES IN THE FAMILIES OF SMYTH, COTTERMAN, AND FREYBERG.


PYRUVATE KINASE DEFICIENT HEMOLYTIC ANEMIA IN AN AMISH ISOLATE.


ESTIMATION OF THE FREQUENCIES OF LINKED GENE PAIRS IN RANDOM MATING POPULATIONS.


ALBINISM AMONG INDIANS IN ARIZONA AND NEW MEXICO.


TRANSMISSION OF THE BLOOD GROUP GENOTYPE PP (TJA-NEGATIVE) IN A KINSHIP WITH MULTIPLE CONSANGUINEOUS MARRIAGES.


A FAMILIAL 4/5 RECIPROCAL TRANSLOCATION RESULTING IN PARTIAL TRISOMY B.


GENETIC STUDIES OF BLOOD GROUP-ASSOCIATED VARIATIONS IN A HUMAN SERUM ALKALINE PHOSPHATASE.


HARDY-WEINBERG EQUILIBRIUM AND PRIMITIVE POPULATIONS.


PTC TASTE SENSITIVITY AND ENDEMIC GOITER IN BRAZIL.


GENETIC LOAD AND UNDETECTED ABORTIONS.

GENETIC LOAD AND UNDETECTED ABORTIONS.


A SEARCH FOR NATURAL SELECTION. MAGNITUDE OF NONBINOMIAL VARIATION IN FAMILY DATA.


RISKS IN ABO AND RH INCOMPATIBILITY.

RISKS IN ABO AND RH INCOMPATIBILITY.


AN ANOMALY OF INHERITANCE IN THE MNSS BLOOD GROUPS.


SEMANTIC POWER MEASURED THROUGH THE INTERFERENCE OF WORDS WITH COLOR-NAMING.


ON THE PRESENTATION OF STIMULUS-OBJECTS IN THE METHOD OF PAIRED COMPARISONS.


DE GUSTIBUS.

DE GUSTIBUS.


COMMITTEE ON THE SCIENTIFIC AND PROFESSIONAL AIMS OF PSYCHOLOGY: PRELIMINARY REPORT.


INSECT STING REACTIONS IN CHILDREN.

INSECT STING REACTIONS IN CHILDREN.


CLINICAL EXPERIENCE AND IMPLICATIONS OF HYPERBARIC OXYGENATION. THE HISTORICAL PERSPECTIVE OF HYPERBARIC THERAPY.


HYPERBARIC OXYGENATION. STANDARD DECOMPRESSION PROCEDURES AND THEIR MODIFICATION IN PREVENTING THE BENDS.


CONTROL OF ACIDOSIS IN HYPERBARIC OXYGENATION.


THE EFFECT OF HEAVY METAL SALTS AND CALCIUM DISODIUM AND MAGNESIUM DISODIUM VERSENATE ON THE ACTIVITY OF SERUM PHOSPHOMONOESTERASE I. IN VITRO STUDIES.


THE EFFECT OF THE VEGETATIVE NERVOUS SYSTEM ON THE BEHAVIOR OF MICROPHONIC POTENTIALS IN THE ORGAN OF CORTI.


COMPLETE MEDICAL CARE INCLUDES REHABILITATION.


A STUDY OF INTRAGLUTEAL INJECTION.

A STUDY OF INTRAGLUTEAL INJECTION.


HEREDITY OF OSTEOARTHRITIS.

HEREDITY OF OSTEOARTHRITIS.


PAIN RESPONSE TO DIFFERENT TETANIZING CURRENTS.


THE ROLE OF PNEUMATIC PUMPING DEVICES IN THE TREATMENT OF POSTMASTECTOMY LYMPHEDEMA.


USE OF SPLINTS IN CONSERVATIVE MANAGEMENT OF ACUTELY INFLAMED JOINTS IN RHEUMATOID ARTHRITIS.


IN MEMORIAN (OTTO GLASSER).

IN MEMORIAN (OTTO GLASSER).


IDIOPATHIC LIPAEMIA RETINALIS.

IDIOPATHIC LIPAEMIA RETINALIS.


TISSUE REPAIR AFTER THE OPERATIONS OF RECESSION AND RESECTION.


ORBITAL INVOLVEMENT IN RIEDEL'S THYROIDITIS.


SEROLOGICAL STUDIES IN SYMPATHETIC OPHTHALMITIS.


TWENTY YEARS OF PSYCHOTHERAPY BY THE NON-PSYCHIATRIST.


ACUTE ANTERIOR UVEITIS IN A PATIENT WITH SARCOIDOSIS AND HIGH TOXOPLASMA DYE TEST TITRE.


SOME NEWER IDEAS AND CONCEPTS OF ALCOHOLISM AND THE USE OF HYPNOSIS. I.


CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS.


RING-LIKE CORNEAL DEPOSITS IN A CASE OF CONGENITAL SPHEROCYTOSIS.


METASTASES IN THE ORBIT.

METASTASES IN THE ORBIT.


HYPNOTIC INDUCTION BY STIMULATION OF EMOTIONAL REACTIONS OF THE STABILIZING TYPE. 2.


BILATERAL OPTIC ATROPHY AFTER VACCINATION AGAINST THE COMMON COLD.


HYPNOSIS AND THE LAW.

HYPNOSIS AND THE LAW.


INCIDENCE OF CILIO-RETINAL ARTERY IN INDIANS.


PRELIMINARY TRIAL OF A NEW HAEMOSTATIC OCTAPRESSIN-SANDOZ.


HYPNOSIS AND SYMPTOM SUBSTITUTION.

HYPNOSIS AND SYMPTOM SUBSTITUTION.


UNUSUAL PENETRATING INJURY OF THE ORBIT.


CIRCULATION IN THE IRIS AND CILIARY PROCESSES, POSSIBLE RECIPROCAL RELATIONSHIP.


HEMODYNAMIC DETERMINANTS OF THE AMPLITUDE OF THE FIRST HEART SOUND.


FURTHER GYNECOLOGICAL CONDITIONS TREATED BY HYPNOTHERAPY.


OBSERVATIONS ON THE USE OF HYPNOSIS WITH BURNED CHILDREN ON A PEDIATRIC WARD.


ACCEPTABILITY OF IRRADIATED FISH AND SHELLFISH.


EVALUATION OF PROTEIN IN SELECTED AMERICAN DIETS.


THE EVOLUTION OF NUTRITION CONCEPTS--PERSPECTIVES AND NEW HORIZONS.


BIOGRAPHICAL NOTES FROM THE HISTORY OF NUTRITION. ELLIOTT PROCTOR JOSLIN--JUNE 6, 1869-JANUARY 28, 1962.


THE CHANGING NATURE OF PUBLIC HEALTH.

THE CHANGING NATURE OF PUBLIC HEALTH.


NUTRITIVE VALUE OF DIETS IN INDIAN BOARDING SCHOOLS IN THE DAKOTAS.


OBLIGATIONS OF THE PRACTICING PHYSICIAN IN TOTAL HEALTH CARE OF THE AGED.


PANEL DISCUSSION--PSYCHIATRIC ASPECTS OF GERIATRIC PATIENTS. SOCIAL AND RELATED FACTORS LEADING TO PSYCHIATRIC HOSPITALIZATION OF THE AGED.


PANEL DISCUSSION--PSYCHIATRIC ASPECTS OF GERIATRIC PATIENTS. A COMPARATIVE STUDY OF THE NEUROPATHOLOGIC FINDINGS IN SENILE PSYCHOSES AND IN "NORMAL" SENILITY.


PROBLEMS IN DRUG MANAGEMENT OF CARDIOVASCULAR DISORDERS IN GERIATRIC PATIENTS.


CONSTANTS OF SENILE DECAY.

CONSTANTS OF SENILE DECAY.


SELECTION OF GEOGRAPHICALLY STABLE SUBJECTS IN LONGITUDINAL STUDIES OF AGING.


PHARMACOLOGIC EFFECTS OF DOXAPRAM IN THE AWAKE HUMAN.


OBSERVATIONS ON THE TREATMENT OF POSTHERPETIC NEURALGIA WITH NANDROLONE.


PHYSICAL, EMOTIONAL AND SOCIAL REHABILITATION IN A NURSING-HOME POPULATION.


CESIUM-131 UPTAKE AND DISTRIBUTION IN THE HUMAN HEART: AN ANALYSIS OF CARDIAC SCANS IN 104 PATIENTS.


CHEMICAL COMPOSITION OF ENZYME-FRACTIONATED AGED HEART TISSUE.


ADDICTION TO DRUGS BY MEDICAL AND PARAMEDICAL PERSONNEL.


ROENTGEN STUDY OF THE SOFT TISSUES OF PREGNANCY.


BASIC PRINCIPLES OF FRACTURE TREATMENT.

BASIC PRINCIPLES OF FRACTURE TREATMENT.


PRIMARY PULMONARY EOSINOPHILIC GRANULOMA (HISTIOCYTOSIS X).


THE NULLIPARA BREECH: AN EVALUATION OF METHODS OF DELIVERY.


THE PHYSICIAN'S RESPONSIBILITY IN "HOPELESS CASES".


FAMILIAL EXOGENOUS OBESITY COMPLICATED BY NONFILARIAL SCROTAL ELEPHANTIASIS: CASE HISTORY.


PIONEERING IN A NEW WORLD.

PIONEERING IN A NEW WORLD.


ECONOMICS AND THE PRACTICING PHYSICIAN.

ECONOMICS AND THE PRACTICING PHYSICIAN.


PLASMA COAGULATION BY ORGANISMS OTHER THAN STAPHYLOCOCCUS AUREUS. Bayliss, Berenice G. (Washington State University, Pullman), and Elizabeth R. Hall. Plasma coagulation by organisms other than Staphylococcus aureus. J. Bacteriol. 89:101-105. 1965.-Approximately 200 organisms were investigated for their ability to clot human and rabbit plasma. Various anticoagulants were used in preparing the plasma: acid-citrate-dextrose, ethylenediaminetetraacetate, balanced oxalate, potassium and sodium oxalates, and heparin. Twelve organisms were found which coagulated citrated plasma in less than 8 hr: four strains of Streptococcus faecalis; two strains of S. faecalis var. zymogenes; three strains of S. faecalis var. liquefaciens; and one strain each of S. pyogenes, Escherichia coli, and Serratia marcescens. Six strains of coagulase-positive Staphylococcus were selected for use as controls. Experiments were performed to determine the mechanism by which these microorganisms coagulated citrated plasma. As this was the only plasma clotted, it was presumed that the citrate was utilized by the microorganisms, thereby releasing the calcium which was then made available so that normal physiological clotting could occur. To test this hypothesis, a chromatographic method was employed to determine the presence or absence of citrate. Coagulation tests, by use of increasing amounts of citrate, showed a linear relationship between the amount of citrate in the plasma and the coagulation time. It was demonstrated that the organisms must be actively metabolizing to clot citrated plasma. Proof for this was obtained by using a cell-free filtrate, to which thimerosal had been added to inhibit growth, instead of whole cultures for the coagulation test. Only the coagulase-positive staphylococci coagulated the citrated plasma under these conditions. From the results obtained, it was concluded that plasma coagulation by these organisms was by citrate utilization.


CYANIDE FORMATION BY CHROMOBACTERIUM VIOLACEUM. Michaels, Ruth (Columbia University, New York, N.Y.), and W. A. Corpe. Cyanide formation by Chromobacterium violaceum. J. Bacteriol. 89:106-112. 1965.-The formation of cyanide by a Chromobacterium violaceum strain was studied with growing cultures and with nonproliferating cells grown in complex and chemically defined media. Most of the cyanide was produced during the log-phase growth of the organism, and accumulated in the culture supernatant fluid. A synergistic effect of glycine and methionine on cyanide formation in a chemically defined medium was observed, and the amount of cyanide formed was found to be dependent on the concentrations of the two substances. Cyanide formation by nonproliferating cells was stimulated by preincubation with glycine and methionine. Cyanide formation by adapted cells in the presence of glycine and methionine was stimulated by succinate, malate, or fumarate, and depressed by azide and 2,4-dinitrophenol. Methionine could be replaced by betaine, dimethylglycine, and choline.


VARIATIONS IN THE ABILITIES OF SEVERAL LINES OF L CELLS TO PRODUCE AND TO BE AFFECTED BY INTERFERON. Lockart, Royce Z., Jr. (The University of Texas, Austin). Variations in the abilities of several lines of L cells to produce and to be affected by interferon. J. Bacteriol. 89:117-122. 1965.-The amounts of interferon produced by three different lines of L cells and mouse embryonic cells when inoculated with two strains of Western equine encephalomyelitis (WEE) virus and Newcastle disease virus (NDV) were determined. One cell line consistently produced more interferon than the others. NDV stimulated more interferon than did WEE virus in all the cell lines tested. The interferons failed to show homologous specificity in their ability to inhibit virus production in the three cell lines. The cell line that produced the most interferon also was most sensitive to viral inhibition. This cell line was also most sensitive to the viral inhibitory ability of an interferon prepared in mouse embryonic cells.


UTILIZATION OF CELLULOSE OLIGOSACCHARIDES BY CELLVIBRIO GILVUS. Schafer, Marion L. (Virginia Polytechnic Institute, Blacksburg), and Kendall W. King. Utilization of cellulose oligosaccharides by Cellvibrio gilvus. J. Bacteriol. 89:113-116. 1965.-The hypothesis that oligosaccharides of the cellulose polymer series can be absorbed by cellulolytic bacteria, prior to hydrolysis to the level of glucose or cellobiose, has been tested. Resting-cell suspensions of Cellvibrio gilvus removed oligosaccharides of one to six monomer units from solution at a rate providing the cells with 37 x 10(6) to 42 x 10(6) molecules of glucose per cell per minute. There was no concurrent extracellular hydrolysis of the oligosaccharides. The fact that the rate of uptake was constant indicates that an active absorption system is involved. Filtrates from washed-cell suspensions before or after exposure to the oligosaccharides were incapable of hydrolyzing the sugars. In media where the carbohydrate concentration was growth-limiting, the larger members of the oligosaccharide series supported greater final cell densities than the smaller sugars, but there were no recognizable differences in the growth rates during the logarithmic-growth phase.


MOLYBDENUM AS A MICRONUTRIENT FOR NITROBACTER. Finstein, M. S. (University of California, Davis), and C. C. Delwiche. Molybdenum as a micronutrient for Nitrobacter. J. Bacteriol. 89:123-128. 1965.-The requirement of Nitrobacter for molybdenum was investigated by use of a medium purified by chemical means, as well as by depletion by the prior growth of this autotrophic bacterium. During 5 days of growth, added molybdenum induced an approximately 11-fold increase in both nitrite utilization and cell-mass development. In short-term studies, maximal response was obtained with concentrations as low as 10(-9)m. No other metal tested substituted for molybdenum. It is estimated that a minimum of 2,000 atoms of molybdenum is required for the synthesis of one Nitrobacter cell. Molybdenum did not directly influence the thermodynamic efficiency of Nitrobacter. The efficiency of molybdenum-deficient cultures and of cultures supplied with the micronutrient declined equally during the early stage of development, despite large differences in the amount of nitrite consumed. After the utilization of about 100 mumoles of nitrite per ml, cultures supplied with molybdenum became relatively less efficient. A procedure is described whereby large masses of Nitrobacter cells can be obtained with relative ease.


METABOLISM OF PENTOSES AND PENTITOLS BY AEROBACTER AEROGENES. 3. PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF PENITOL DEHYDROGENASES AND PENTULOKINASES. Mortlock, R. P. (Michigan State University, East Lansing), D. D. Fossitt, D. H. Petering, and W. A. Wood. Metabolism of pentoses and pentitols by Aerobacter aerogenes. III. Physical and immunological properties of pentitol dehydrogenases and pentulokinases. J. Bacteriol. 89:129-135. 1965.-Four pentulokinases and three pentitol dehydrogenases were purified from Aerobacter aerogenes PRL-R3, and the properties of the enzymes within each family were compared. d-Ribulokinase was purified from cells grown on ribitol, d-arabitol, and xylitol, and from a mutant constitutive for ribitol dehydrogenase; d-xylulokinase, from cells grown on d-xylose and xylitol; l-ribulokinase, from cells grown on l-arabinose; and l-xylulokinase, after growth on l-xylose. Similarly, ribitol dehydrogenase was purified after growth on ribitol, d-arabinose, and xylitol, and from the ribitol dehydrogenase-constitutive mutant. d-Arabitol dehydrogenase was obtained after growth on d-arabitol or d-xylose, and xylitol dehydrogenase was obtained after growth on xylitol. Except for l-xylulokinase, which also had a different S(20) value, the pentulokinases had identical pH optima, K(m) for the ketopentose, and sedimentation constants, and fractionated identically by a number of procedures. These kinases could be distinguished only by their substrate and immunological specificity. Ribitol dehydrogenase and d-arabitol dehydrogenase could be distinguished by several properties, but the properties of xylitol dehydrogenase were always similar to ribitol dehydrogenase. In all cases, individual kinases or dehydrogenases produced by different inducers had identical properties. These data constitute evidence against multiple forms of the same enzyme being produced by different inducers and against the dehydrogenase family containing essentially identical proteins differing only at the active site. For the kinases, three of the four appear to differ only at the active site.


NEW METHOD OF PREPARING IMMUNIZING ANTIGENS FOR THE PRODUCTION OF ANTI-M SERA AGAINST CERTAIN SEROTYPES OF GROUP A STREPTOCOCCI. Ashworth, Helen (Communicable Disease Center, Atlanta, Ga.), and William K. Harrell. New method of preparing immunizing antigens for the production of anti-M sera against certain serotypes of group A streptococci. J. Bacteriol. 89:141-145. 1965.-Antisera against types 4, 29, 41, and 46 streptococci have been prepared by use of a vaccine killed by adjusting the pH to 11.7 and heating for 1 hr at 56 C. Heating at the high pH destroyed the antigenic material responsible for the major reciprocal crosses present in cells of types 4, 29, and 46 without affecting the M protein. Antisera prepared with the "alkaline-treated" vaccine did not contain the major reciprocal crosses. Antibodies against the M protein were shown to be present by the bactericidal test, failure to react in the precipitin test with acid extracts of homologous trypsinized cells, and retention of the precipitin reaction after absorption with homologous trypsinized cells. The antisera did not react with the "B" antigen of the provisional type B 3264. Type 11 antisera prepared with alkaline-treated vaccine did not contain antibodies against the M protein. The usefulness of this type vaccine, particularly for the preparation of type 4 antiserum, is discussed, as well as its limitations.


INCORPORATION OF HYDROXYLYSINE INTO THE CELL WALL AND A CELL-WALL PRECURSOR IN STAPHYLOCOCCUS AUREUS. Smith, W. Grady (University of Minnesota, St. Paul), Daniel P. Gilboe, and L. M. Henderson. Incorporation of hydroxylysine into the cell wall and a cell-wall precursor in Staphylococcus aureus. J. Bacteriol. 89:136-140. 1965.-Recent work has shown that hydroxylysine can substitute for lysine in cell-wall synthesis of Streptococcus faecalis, apparently becoming incorporated into cell-wall mucopeptide. This paper extends these observations to investigate the metabolism of hydroxylysine in Staphylococcus aureus, an organism from which sufficiently large quantities of cell-wall precursors. uridine diphosphate-N-acetylmuramyl peptides, could be obtained. Hydroxylysine has been shown to be incorporated into the cell-wall precursor uridine diphosphate-N-acetylmuramyl l-ala.d-glu. l-lys.d-ala.d-ala from S. aureus (Copenhagen) apparently in lieu of lysine. Hydroxylysine was also incorporated into the cell-wall mucopeptides of S. aureus in resting cultures. This incorporation was inhibited by penicillin or lysine, but not by chloramphenicol. Hydroxylysine had little effect on the incorporation of lysine into S. aureus. Hydroxylysine acted as a growth inhibitor in this organism; the inhibition was reversed by lysine.


HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. 3. DEPRESSION OF RETICULOENDOTHELIAL FUNCTION BY STREPTOCOCCAL PYROGENIC EXOTOXINS. Hanna, Edgar E. (University of Minnesota, Minneapolis), and Dennis W. Watson. Host-parasite relationships among group A streptococci. III. Depression of reticuloendothelial function by streptococcal pyrogenic exotoxins. J. Bacteriol. 89:154-158. 1965.-Measurement of the rate of clearance of colloidal carbon from the circulating blood is an effective and simple technique for assessing the functional state of the reticuloendothelial system (RES) of experimental animals. This paper concerns a study of the RES function in rabbits after treatment with streptococcal pyrogenic exotoxins. Intravenous injection of 1.0 ml of the toxin produced by a strain of type 18, group A streptococcus caused a prolonged (at least 24 hr) depression of RES function. The activity at 48 hr after toxin injection was about equal to that in control animals. Repeated intravenous injections of the toxin abolished the initial depressing effect on RES function, but did not cause stimulation. In comparison, intravenous injection of equivalent doses of endotoxin prepared from Escherichia coli COO8 also caused an initial depression of RES function; however, in contrast with the effect of exotoxin, stimulation occurred as early as 24 hr and was about twice as active at 48 hr. The prolonged depression by streptococcal pyrogenic exotoxin is suggested as one means by which this toxin potentiates lethality and tissue damage by other toxins such as streptolysin O and endotoxins from gram-negative bacteria.


COMPARATIVE BIOSYNTHESIS OF MEVALONIC ACID BY MYCOPLASMA. Smith, Paul F. (University of South Dakota, Vermillion), and C. V. Henrikson. Comparative biosynthesis of mevalonic acid by Mycoplasma. J. Bacteriol. 89:146-153. 1965.-Three representative Mycoplasma, M. laidlawii strain B, M. gallisepticum strain J, and M. hominis strain 07, were examined for the presence or absence of enzymes associated with the biosynthetic pathway to mevalonic acid. M. laidlawii served as a control, because it synthesizes carotenoids from acetate. M. laidlawii was shown to contain a specific acetokinase and phosphotransacetylase for the synthesis of acetyl coenzyme A, and a beta-ketothiolase and coenzyme A transferase for the synthesis of acetoacetyl coenzyme A. M. gallisepticum contained a specific acetokinase, phosphotransacetylase, and possibly an aceto coenzyme A kinase forming acetyl coenzyme A; it also contained a beta-ketothiolase, a coenzyme A transferase, and a coenzyme A transphorase forming acetoacetyl coenzyme A directly or indirectly. The beta-ketothiolase of M. gallisepticum was not affected by iodoacetamide, in contrast to the other two strains. M. laidlawii exhibited beta-hydroxy-beta-methylglutaryl coenzyme A condensing enzyme, and M. hominis did not. This activity of M. gallisepticum was masked by thiolase activity. M. laidlawii and M. gallisepticum contained a nicotinamide adenine dinucleotide phosphate-linked beta-hydroxy-beta-methylglutaryl coenzyme A reductase, and M. hominis did not. C(14)-labeled acetate was incorporated into mevalonic acid only by M. laidlawii and M. gallisepticum. The lack of beta-hydroxy-beta-methylglutaryl coenzyme A condensing enzyme and reductase activities in M. hominis explains its growth requirement for sterol. The enzymatic block in M. gallisepticum must occur after mevalonic acid in the biosynthetic pathway to terpenoids.


COLORIMETRIC DETERMINATION OF COLOR OF AERIAL MYCELIUM OF STREPTOMYCETES. Lyons, Allister J., Jr. (Northern Regional Research Laboratory, Peoria, Ill.) and Thomas G. Pridham. Colorimetric determination of color of aerial mycelium of streptomycetes. J. Bacteriol. 89:159-169. 1965.-For some time, streptomycete taxonomists have been seeking to describe more accurately the colors of aerial mycelium. Some of the descriptive systems involve many different color names and groups. Others combine many colors into a few groups. All the systems and methods leave much to be desired. To obtain an accurate description, a colorimeter with a reflectance attachment was used to examine streptomycete aerial mycelium of 37 strains, representing all of the major aerial mycelium color groups. Each color was characterized by three values: dominant wavelength in millimicrons, and purity and brightness in percentages. All colors of aerial mycelium were of low purity (< 25%). Most of the dominant wavelengths were in the yellow to yellow-green bands of the spectrum. Most of the color tabs matched visually with the streptomycete strains had purities of a higher value than those of the cultures. The reflectance instrument seems to allow an objective description, and its use may help to clarify the color problem with streptomycetes. It is concluded that present color descriptions are inadequate and that the significance of color in speciation requires critical examination.


INDUCTION OF PARTIAL SPECIFIC HETEROTYPIC IMMUNITY IN MICE BY A SINGLE INFECTION WITH INFLUENZA A VIRUS. Schulman, Jerome L. (Cornell University Medical College, New York, N.Y.), and Edwin D. Kilbourne. Induction of partial specific heterotypic immunity in mice by a single infection with influenza A virus. J. Bacteriol. 89:170-174. 1965.-Mice infected 4 weeks previously with influenza A virus were found to be partially immune when challenged with influenza A2 virus. This partial immunity was demonstrated by reduced titers of pulmonary virus, decreased mortality, and less extensive lung lesions. A specific immunological basis for this protection was suggested by the absence of any protection in animals previously infected with influenza B virus when challenged with A2 virus, or in animals previously infected with influenza A virus when challenged with influenza B virus. Parenteral inoculation with inactivated influenza A virus did not induce partial immunity to A2 virus challenge. An accelerated rise of hemagglutinating-inhibiting antibody after A2 virus challenge was demonstrated in animals previously infected with influenza A virus.


INDUCTION AND PROPERTIES OF A TEMPERATURE  BACTERIOPHAGE FROM BACILLUS STEAROTHERMOPHILUS. Welker, N. E. (University of Illinois, Urbana), and L. Leon Campbell. Induction and properties of a temperate bacteriophage from Bacillus stearothermophilus. J. Bacteriol. 89:175-184. 1965.-Bacillus stearothermophilus 1503-4R growing at 55 C was induced to lyse either when 0.05 mug/ml of mitomycin C was added or when it was exposed to ultraviolet light for 30 sec. Lysis of the induced cultures occurred 45 to 60 min after induction. Phage were assayed on B. stearothermophilus 4S giving turbid plaques 0.05 to 0.3 cm in diameter. Noninduced cultures of 1503-4R spontaneously produced one phage per 2.8 x 10(6) bacterial cells. The optimal temperature for phage production and assay was found to be 55 C. B. stearothermophilus 1503-4R was immune to the isolated temperate phage (TP-1) and to a clear-plaque mutant phage (TP-1C), even when tested at phage mutliplicities of 100. TP-1 and TP-1C phage were identical morphologically having a head 65 mmu in diameter and a tail 240 mmu long and 12 mmu wide. TP-1C phage deoxyribonucleic acid (DNA) had an S(20,w) value of 24.1 and a calculated molecular weight of 1.21 x 10(7). DNA base compositions of TP-1 and TP-1C phage were identical (42% guanine + cytosine), but differed significantly from those of the lysogenic or indicator strains of B. stearothermophilus (50% guanine + cytosine). No unusual bases were detected in either the bacterial or phage DNA.


CHANGES IN MOUSE PNEUMONITIS AGENT ASSOCIATED WITH DEVELOPMENT OF RESISTANCE TO CHLORTETRACYCLINE. Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Novosel, and Ilse I. E. Tribby. Changes in mouse pneumonitis agent associated with development of resistance to chlortetracycline. J. Bacteriol. 89:17-22. 1965.-A chlortetracycline-resistant mutant of mouse pneumonitis agent, a member of the psittacosis group of microorganisms, differed in several ways from the susceptible stock from which it had been derived by serial chick-embryo passage in the presence of the antibiotic. It was almost completely resistant to chlortetracycline, had a longer growth cycle, produced many more very large particles, was not neutralized by parent antiserum and vice versa, was 10 times as resistant to d-cycloserine, and was highly lethal to mice when inoculated intracerebrally. These changes probably do not occur independently of one another but are the reflection of some genetically controlled change in the surface structure of the mouse pneumonitis particle which enables the resistant mutant to multiply in the presence of chlortetracycline.


CORRELATION OF SUCCINATE METABOLISM AND VIRULENCE IN SALMONELLA TYPHIMURIUM. Herzberg, Mendel (University of Florida, Gainesville), and Mudhaffer J. Jawad, and Darrell Pratt. Succinate metabolism and virulence in Salmonella typhimurium. J. Bacteriol. 89:185-192. 1965.-A virulent, smooth strain of Salmonella typhimurium (Wild-7) grew slowly with succinate as sole carbon source (Suc-L). Old stock cultures yielded a smooth variant which grew rapidly (Suc-E). Visible colonies of Suc-E appeared in 24 hr, whereas Suc-L required 48 hr. Differences other than the response to succinate were not demonstrable between the two strains; ld(50) values of both strains were similar, but equivalent numbers of Suc-E required longer periods of time to kill mice. Recovery of bacteria from liver and spleen homogenates revealed that Suc-L remains as such in vivo, but Suc-E populations change to Suc-L. By the eighth day of infection, the organisms were 93 to 100% Suc-L; thus, mortality was due to the Suc-L population developed in vivo and not the Suc-E of the original inoculum. Animal passage of a number of stock cultures of S. typhimurium of diverse origin, all Suc-E type, invariably yielded Suc-L. Slow utilization of succinate appears to be correlated with virulence.


CLINICAL APPLICATION OF IMMUNOFLUORESCENCE. I. GROUPING BETA-HEMOLYTIC STREPTOCOCCI. Smith, Thomas B. (Armed Forces Institute of Pathology, Washington, D.C.). Clinical application of immunofluorescence. I. Grouping beta-hemolytic streptococci. J. Bacteriol. 89:198-204. 1965.-Procedures are described for the production of antistreptococcal serum in rabbits and for the preparation of group-specific conjugates for Lancefield groups A, C, and G. A modification of the conventional technique of absorption and inhibition to prevent cross-reactions with common antigens was used with excellent results. In addition, a promising new approach to eliminating cross-reactions of group A conjugate with antigens of groups C and G by dilution with group A-variant antiserum was tested. A complete method is introduced that enables the clinical laboratory to report whether group A streptococci are present in a given throat culture well within 24 hr after the physician collects the sample.


EXPERIMENTAL SALMONELLOSIS. IV. LIPID CONTENT OF TOXIN L OBTAINED FROM SALMONELLA ENTERITIDIS. Kawakami, Masaya (Gunma University, Maebashi, Japan), and Susumu Mitsuhashi. Experimental salmonellosis. IV. Lipid content of toxin L obtained from Salmonella enteritidis. J. Bacteriol. 89:193-197. 1965.-An improved method is described for the chromatographic purification of toxin L from virulent Salmonella enteritidis. Toxin L is heat-labile, and its toxicity is reduced by trypsin and by phospholipase A treatment. Chemical studies of chromatographically and ultracentrifugally homogeneous toxin preparations show that toxin L is a phosphorus-containing protein. The infrared-absorption spectrum of a petroleum ether extract of toxin L hydrolysate indicates that this material possesses a lipid component.


COLIFORM ENTERITIS OF COTTONTAIL RABBITS. Yuill, Thomas M. (University of Wisconsin, Madison), and Robert P. Hanson. Coliform enteritis of cottontail rabbits. J. Bacteriol. 89:1-8. 1965.-Mortality from enteritis occurred among 78 penned adult cottontail rabbits (Sylvilagus floridanus) during severe winter weather, and in 9 juvenile rabbits held in captivity during the summer. This mortality was associated with high numbers of Escherichia coli throughout the intestinal tract. Grossly normal cottontails from the laboratory, from the outdoor penned colony, and from the wild had few E. coli, and these were usually restricted to the lower gut. It was possible to induce mortality of adult rabbits by holding them at -20 C for 2 to 14 days. The animals that died during exposure to low temperatures had signs of enteritis and high numbers of E. coli throughout the intestinal tract. It was possible to prolong the life of cottontails held at -20 C by antibiotic suppression of their intestinal E. coli. A marked slowing in the rate of passage of materials through the intestine ensued after exposure at -20 C. This phenomenon may have been important in the alteration of the distribution of the intestinal microflora. Limited infection by E. coli occurs in rabbits in the wild. Of 47 serum samples from grossly normal cottontails collected in the wild, 42 contained E. coli agglutinins. The rabbit's defenses are apparently sufficient to control this organism under all but extremely unfavorable circumstances. The age of the rabbit appeared to influence its susceptibility to enteritis. Juvenile rabbits experienced enteritis, tissue invasion, and death under conditions which did not produce any enteric changes in adults.


CYTOTOXIC EFFECT OF MYCOBACTERIA ON EHRLICH ASCITES CELLS. Bekierkunst, Adam (Bryn Mawr College, Bryn Mawr, Pa.), and L. Joe Berry. Cytotoxic effect of mycobacteria on Ehrlich ascites cells. J. Bacteriol. 89:205-211. 1965.-Mycobacterium tuberculosis, strains H(37)Rv, H(37)Ra, and BCG, release into a medium within 3 to 5 hr a substance that is toxic to Ehrlich ascites cells as evidenced by a diminished packed cell volume after 5 to 7 days of growth in the peritoneal cavity of mice. Cell-free extracts of the above strains of mycobacteria display the same type of cytotoxic effect, the strongest action being that of the virulent strain, H(37)Rv. The nicotinamide adenine dinucleotidase activity of surviving tumor cells was three to four times greater after treatment with the mycobacterial extracts than that of control cells. The cycotoxicity is probably due to cord factor, because 10 mug of this substance injected intraperitoneally into mice bearing Ehrlich ascites cells inhibited the growth of the cells to 50% of that of control cells. An increase in nicotinamide adenine dinucleotidase activity was found in surviving tumor cells after cord factor treatment.


TIME-LAPSE PHOTOMICROGRAPHY OF CELL GROWTH AND DIVISION IN ESCHERICHIA COLI. Hoffman, Heiner (New York University, New York, N.Y.), and Michael E. Frank. Time-lapse photomicrography of cell growth and division in Escherichia coli. J. Bacteriol. 89:212-216. 1965.-Photomicrographs at 15-sec intervals of cells growing at 37 C disclosed that in a cell with a generation time of 21.0 min the processes of furrowing, cross-wall formation, and cell separation are completed within 2.5 min after the division furrow first becomes clearly visible. Among a large number of cultivations examined, only a few cells late in one microculture at 43.5 C failed to separate once the cross wall was completed. Measurements of cell lengths during a 5-min period, extending from just before to just after division, showed that elongation of the cell is a discontinuous process, although the growth rate over the 5-min period is exponential. At the time of cell division, it appears that the synthesis of cell-wall material is diverted entirely into formation of the cross wall.


ELECTRON MICROSCOPIC OBSERVATION OF THE SPORANGIAL STRUCTURE OF A STRAIN OF ACTINOPLANES. Lechevalier, Hubert (Rutgers, The State University, New Brunswick, N.J.), and Pauline E. Holbert. Electron microscopic observation of the sporangial structure of a strain of Actinoplanes. J. Bacteriol. 89:217-222. 1965.-Actinoplanes sp. P 128 has polarly flagellated sporangiospores. The numerous flagella, formed by the helical winding of subfibrils, were seen clearly only in shadowed preparations. Flagella were never seen in sections of spores. Sporangial formation was followed by examining sections of sporangia at various stages of maturity. The sporangial envelope was the continuation of the outer sheath of the sporangiophore. The sporangiospores were formed by the division of hyphae enclosed within the sporangial wall. The spores were probably formed by simultaneous division of these hyphae. An intersporal substance, which seemed to originate from the outer sheaths of the intrasporangial hyphae, could be seen.


ELECTRON MICROSCOPY OF LEPTOSPIRES. I. ANATOMICAL FEATURES OF LEPTOSPIRA POMONA. Ritchie, A. E. (National Animal Disease Laboratory, Ames, Iowa), and Herman C. Ellinghausen. Electron microscopy of leptospires. I. Anatomical features of Leptospira pomona. J. Bacteriol. 89:223-233. 1965.-Anatomical features of Leptospira pomona are described. Most cells in the logarithmic phase of growth, when examined in whole cell "negative-stained" preparations, display a homogeneous finely granular protoplasmic cylinder. Some cells contain discrete or complex lamellar structures. The cell termini are attached to the protoplasmic cylinder by a membrane system. Each organism appears to have two independent axial filaments originating from opposite ends of the cell. The axial filaments are composed of a closely knit bundle of some 12 to 15 individual strands. A simple model suggesting a locomotory function for the axial filaments is presented. A superficial callouslike mass is occasionally observed in the cell's terminal region. The enveloping sheath is similar to the cytoplasmic membrane; both are triple-layered and ca. 50 A thick. The sheath preferentially forms blebs at the cell termini and midway along the protoplasmic cylinder. Septal-wall formation occurs at the mid region of the cell, and it is concluded that simple transverse binary fission is the predominant mode of reproduction.


MULTIPLE CELLULASE SYSTEM FROM STREPTOMYCES ANTIBIOTICUS. Enger, M. D. (North Dakota State University, Fargo), and B. P. Sleeper. Multiple cellulase system from Streptomyces antibioticus. J. Bacteriol. 89:23-27. 1965.-Starch-block zone electrophoresis was used to isolate five electrophoretically distinct, active cellulolytic components (I to V) from the crude extracellular cellulase system of Streptomyces antibioticus (strain C2A). Agar diffusion precipitin analyses demonstrated the immunological identity of components I, II, and III, and the nonidentity of IV and V with each other and with I to III. Kinetic studies of the purified enzymes showed a sharp decrease in the viscosity of the substrate, carboxymethylcellulose, with only a small increase in reducing sugars. These results indicated that all five enzymes are endocellulases.


MORPHOLOGICAL CHANGES IN POLY-BETA-HYDROXYBUTYRATE GRANULES ASSOCIATED WITH DECREASED SUSCEPTIBILITY TO ENZYMATIC HYDROLYSIS. Merrick, J. M. (State University of New York, Buffalo), D. G. Lundgren, and R. M. Pfister. Morphological changes in poly-beta-hydroxybutyrate granules associated with decreased susceptibility to enzymatic hydrolysis. J. Bacteriol. 89:234-239. 1965.-A complex enzyme system obtained from extracts of Rhodospirillum rubrum cells hydrolyzes poly-beta-hydroxybutyric acid (PHB) contained in native PHB granules isolated from Bacillus megaterium. A labile factor associated with the granules and necessary for depolymerization is easily destroyed by various chemical and physical treatments. Granules inactivated by these treatments were examined in an electron microscope. In all cases, the distinct morphological appearance of native granules was altered. Morphological changes were mainly characterized by membrane fragmentation, loss of coalescence, and surface alterations. These observations suggest that native PHB granules possess definite structural features, disruption of which results in decreased susceptibility of the polymer to enzymatic hydrolysis.


ELECTRON MICROSCOPIC OBSERVATIONS ON ACTINOPHAGES FOR STREPTOMYCES VENEZUELAE. Painter, B. G. (University of Minnesota, Minneapolis), and S. G. Bradley. Electron microscopic observations on actinophages for Streptomyces venezuelae. J. Bacteriol. 89:240-244. 1965.-Actinophages MSP2 and MSP8 were treated with various chemical agents to determine the phages' substructure. Normal MSP2 and MSP8, shadowed with uranium, or negatively stained with uranyl acetate or phosphotungstic acid, were tadpole-shaped. The average overall length of MSP2 was 245 mmu, and of MSP8, 206 mmu. The head width of both phages was approximately 58 mmu; the tail of MSP2 was 161 mmu long, and of MSP8, 137 mmu. Treatment of MSP2 and MSP8 with 7.5 m ammonium hydroxide at 56 C or 8 m urea at room temperature released some of the head contents, and revealed substructures in both the heads and the tails. The tails of phages treated with 7.5 m mercaptoethanol were destroyed.


CHARACTERIZATION OF POLY-BETA-HYDROXYBUTYRATE EXTRACTED FROM DIFFERENT BACTERIA. Lundgren, D. G. (Syracuse University, Syracuse, N.Y.), R. Alper, C. Schnaitman and R. H. Marchessault. Characterization of poly-beta-hydroxybutyrate extracted from different bacteria. J. Bacteriol. 89:245-251. 1965.-Poly-beta-hydroxybutyrate (PHB) from different bacterial genera was studied with regard to its crystal structure, infrared absorption, intrinsic viscosity, and electron microscopy. All PHB samples precipitated from dilute chloroform solution gave identical X-ray diffractograms confirming uniformity of crystal structure, and uniformity of molecular structure, based on the similarity of the recorded infrared spectra, was also established. Crystal morphology was also similar, showing the reported "lath" shape structure for purified polymer from Bacillus cereus. Intrinsic viscosity ranged from 0.04 to 11.5 depending upon the polymer treatment; polymer molecular weights, based upon viscometry, could be estimated to range from 1,000 to 250,000. It is concluded that the same basic molecule is involved in all PHB present in the bacterial kindgom.


EVIDENCE FOR A PERSISTENT VIRAL INFECTION IN A CELL LINE DERIVED FROM BURKITT'S LYMPHOMA. Henle, Gertrude (Children's Hospital of Philadelphia, Philadelphia, Pa.), and Werner Henle. Evidence for a persistent viral infection in a cell line derived from Burkitt's lymphoma. J. Bacteriol. 89:252-258. 1965.-Exposure of a cell line (EB2) derived from Burkitt's lymphoma to vesicular stomatitis (VSV) and certain other viruses revealed a marked resistance of the cultures to infection. Intact, but not disintegrated lymphoma cells induced resistance to VSV in human embryonic kidney, amnion and diploid, as well as in green monkey kidney cells employed as feeder layers. A line of rabbit kidney or Earle's strain L cells was not protected under similar conditions. Depending upon the number of EB2 cells initially transferred, resistance developed within 1 day or in more than 2 weeks. Cell-free media collected from cultures of EB2 cells in the presence or absence of feeder layers of human cells were capable of conferring rapid protection against VSV to human-cell cultures but not to L cells. The protective principle complies with present criteria for an interferon. The results are compatible with the suggestion that EB2 cultures are latently infected with an as yet unidentified virus.


LACTOSE AND SULFIDE REACTIONS OF AN ABERRANT SALMONELLA STRAIN.


TRANSFORMABLE THYMINE-REQUIRING MUTANT OF BACILLUS SUBTILS.


PHOSPHATIDYL GLYCEROL IN THIOBACILLUS THIOOXIDANS.


IDENTITY OF PSEUDOMONAS SACCHAROPHILA.

IDENTITY OF PSEUDOMONAS SACCHAROPHILA.


CHROMOSOMAL ABERRATIONS ASSOCIATED WITH MUTATIONS TO BACTERIOPHAGE RESISTANCE IN ESCHERICHIA COLI. Curtiss, Roy, III (University of Chicago, Chicago, Ill., and Oak Ridge National Laboratory, Oak Ridge, Tenn.). Chromosomal aberrations associated with mutations to bacteriophage resistance in Escherichia coli. J. Bacteriol. 89:28-40. 1965.-Ten types of mutants of Escherichia coli K-12 resistant to bacteriophage T(3) have been isolated, and several of these types have been studied genetically. Many of the /3,4,7, /3,4,7,lambda, and /3,4,7,lambda,pro(-) (1,2) mutants were unstable, changing to complete sensitivity to T(4). The results with strains having /3,4,7,lambda,pro(-) (1,2) mutations were compatible with the hypothesis that this mutation caused a single break in the circular chromosome which prevented the normal association in the inheritance of the outside markers leu(+) and lac(+). When sensitivity to T(4) was regained, association in the inheritance of outside markers was restored, and the resulting /3,7,lambda,pro(-) (1,2) mutation behaved genetically as a deletion. The /3,7,lambda,pro(-) (1,2) and /3,4,7,lambda,pro(-) (1,2) mutations caused positive interference, inhibition of genetic recombination in regions adjacent to them, and the formation of unstable partial diploid recombinants. One group of /3,4,7,lambda mutations did not occur in the leu to try region of the bacterial genome. Other /3,4,7,lambda mutations in F(-) bacteria prevented the joint inheritance of the outside markers lac(+) and gal(+), presumably by breakage of the circular chromosome. Hfr and F(+) strains with /3,4,7,lambda mutations at this locus were unable to conjugate; therefore, a complete genetic analysis of the effects of this /3,4,7,lambda mutation could not be done.


PHOTODYNAMIC INACTIVATION OF ENTEROVIRUSES. Wallis, Craig (Baylor University College of Medicine, Houston, Tex.), and Joseph L. Melnick. Photodynamic inactivation of enteroviruses. J. Bacteriol. 89:41-46. 1965.-Enteroviruses are usually resistant to photodynamic inactivation, but they can be rendered completely photosensitive to proflavine at pH 9 to 10, if they are first purified by filtration through an anion resin. In addition, if enteroviruses are grown in cells maintained in a salt-glucose medium, they can be photosensitized. Of 38 enteroviruses tested, 10 were rendered completely photosensitive to proflavine, or toluidine blue, or both, and the remaining 28 viruses were sensitized, but to a lesser degree. The binding of dye to the virus can be reversed by lowering the pH.


INFECTIVITY OF POLIOVIRUS AND ITS NUCLEIC ACID FOR DEHYDRATED HELA CELL MONOLAYERS. Smull, Christine E. (The Geisinger Medical Center, Danville, Pa.), and E. H. Ludwig. Infectivity of poliovirus and its nucleic acid for dehydrated HeLa cell monolayers. J. Bacteriol. 89:52-57. 1965.-A study was made of the infectivity of poliovirus ribonucleic acid (RNA), applied in various diluents, and of poliovirus, on cell monolayers which were washed free from their nutrient medium and allowed to dehydrate for periods up to 3 days prior to inoculation. The plaque formation of poliovirus RNA, applied in isotonic diluent, was greatly increased when assayed on cell monolayers dehydrated for certain periods of time. Conditions are described for bringing about optimal plaque formation by this means, and evidence is presented which strongly indicates that dehydration of the cell is an important factor in the increase in plaque formation of the poliovirus RNA. The plaque formation of poliovirus RNA in certain hypertonic diluents and in a basic protein-containing diluent was also improved with the use of dehydrated cell monolayers, whereas the plaque formation of poliovirus varied very little when assayed on cell monolayers dehydrated for periods up to 2 days. Under certain conditions, the size of the plaques increased as the dehydration time of the cell monolayers was increased. This was true with plaques initiated either by poliovirus or the nucleic acid. Further investigation in these cases revealed that virus production at given times was considerably greater in the dehydrated than in the undried cell monolayers.


EFFECT OF HIGH FAT DIETS ON INTESTINAL MICROFLORA AND SERUM CHOLESTEROL IN RATS. Graber, C. D. (Baylor University College of Medicine, Houston, Tex.), R. M. O'Neal, and E. R. Rabin. Effect of high fat diets on intestinal microflora and serum cholesterol in rats. J. Bacteriol. 89:47-51. 1965.-Differential bacterial counts of feces and total plasma cholesterol determinations were performed on 60 Wistar rats fed several high lipid diets for a period of approximately 6 months. Fecal flora remained relatively stable irrespective of diet, but cholesterol levels rose in animals fed butter and sodium cholate. The six most commonly cultured organisms in all diets were enterococci, Proteus, lactobacilli, Escherichia coli, Staphylococcus aureus, and other micrococci. No enteric pathogens which did not ferment lactose or fermented it slowly were grown. Fungi and yeasts were rare. Aerobes generally outnumbered anaerobes in proportions which were sometimes as high as 300:1. Clostridium perfringens isolations were consistently high in animals given the butter diets, particularly when sodium cholate was added. Evidence is reviewed which indicates that this organism may play a role in bile salt and cholesterol metabolism. This experiment would seem to demonstrate that differences in plasma-cholesterol levels among the various dietary groups of rats were the result of dietary factors rather than alteration in intestinal flora.


BIOCHEMICAL AND GENETIC GROUPING OF ISOLEUCINE-VALINE MUTANTS OF PSEUDOMONAS AERUGINOSA. Pearce, L. E. (University of Otago, Dunedin, New Zealand), and J. S. Loutit. Biochemical and genetic grouping of isoleucine-valine mutants of Pseudomonas aeruginosa. J. Bacteriol. 89:58-63. 1965.-Isoleucine- and valine-requiring mutants of Pseudomonas aeruginosa, induced with ultraviolet and ethyl-methane-sulfonate, were isolated. The feeding properties and growth requirements of 56 of these mutants were examined, and evidence was found for at least four phenotypic groups, A, B, C, and D, controlling the biosynthesis of isoleucine and valine. Preliminary genetic mapping by use of bacteriophage-mediated transduction showed linkage between the mutant loci within groups A, B, and C. There was also evidence of linkage between the genes controlling groups A and B and some slight evidence of linkage between the other groups. There was insufficient evidence to suggest the arrangement of the genes.


QUANTITATIVE ASSAY FOR CRUDE ANTHRAX TOXINS. Haines, Bertram W. (U.S. Army Biological Laboratories, Frederick, Md.), Frederick Klein, and Ralph E. Lincoln. Quantitative assay for crude anthrax toxins. J. Bacteriol. 89:74-83. 1965.-The whole crude toxins of Bacillus anthracis, although apparently responsible for the death of animals with anthrax, had never been quantitated. A total of 14 lots of the toxic culture filtrate of B. anthracis were pooled into one large lot of crude anthrax toxins. An extensive assay of this reference material was conducted in four laboratories by use of the time-to-death of the intravenously challenged Fischer 344 rat as the response variable. Doses of the material were varied factorially by concentration, dilution, and volume. The data from this study were used to define a potency unit of the crude anthrax toxins. Procedures were developed and illustrated for the assay of unknown lots of the toxins by comparing the rat time-to-death response to the unknown with either (i) the responses reported in this study, or (ii) directly with the rat responses to a new sample of the reference toxins. The possibilities and limitations of this standardization and of the statistical procedure through which it was developed are discussed.


INTRACELLULAR FATE OF MENGO VIRUS RIBONUCLEIC ACID. Homma, M. (The Wistar Institute, Philadelphia, Pa.), and A. F. Graham. Intracellular fate of Mengo virus ribonucleic acid. J. Bacteriol. 89:64-73. 1965.-P(32)-labeled, purified preparations of Mengo virus adsorbed rapidly and irreversibly to L cells maintained in suspension cultures. At intervals after adsorption of labeled virus, the total ribonucleic acid (RNA) of infected cells was extracted by a phenol technique. Infectivity titrations on this RNA showed that it retained its full biological activity during the early part of the eclipse period. Sucrose gradient sedimentation analyses showed also that this RNA lost none of its structural integrity throughout the eclipse period. No evidence was found for a double-stranded structure involving parental RNA. When cells infected with P(32)-labeled virus were broken open during the first 7 hr after infection, no more than 20% of the parental RNA could be digested with ribonuclease. Electron microscopy indicated that only one particle in five of the purified viral populations was infectious. It is suggested that only one of five adsorbed virus particles was uncoated and that its RNA remained in the cell in an undegraded form during the eclipse period. The other adsorbed particles were not uncoated and took no part in the process of infection. The maximal transfer of parental RNA to progeny virus was 4.5%.