MYCOTIC FALSE ANEURYSM OF THE AORTA FOLLOWING AORTIC VALVULAR PROSTHESIS; A CASE REPORT.


PARTIAL ANOMALOUS PULMONARY VENOUS DRAINAGE WITH INTACT INTERATRIAL SEPTUM ASSOCIATED WITH CONGENITAL MITRAL STENOSIS.


PATHOLOGY OF LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION.


RECOGNITION OF LEFT VENTRICULAR OUTFLOW OBSTRUCTION.


OBSTRUCTIVE LESIONS OF THE LEFT VENTRICULAR OUTFLOW TRACT; SURGICAL TREATMENT.


EVALUATION OF TOLAZAMIDE IN THE TREATMENT OF DIABETES MELLITUS.


ABSORPTION AND EXCRETION OF A NEW SEMISYNTHETIC PENICILLIN (BETACIN) IN MAN.


THE TREATMENT OF HEARTBURN OF PREGNANCY WITH A NEW ANTACID.


ABSORPTION OF ORAL NEOMYCIN IN INFANT WITH GASTROENTERITIS.


A TRIAL OF SLOW-RELEASE TABLETS OF FERROUS SULPHATE.


CLINICAL TRIAL OF ISOCARBOXAZID.

CLINICAL TRIAL OF ISOCARBOXAZID.


DIAGNOSIS NEEDED IN APPLYING FIXED PARTIAL DENTURE PROSTHESES.


PRACTICE ADMINISTRATION AND RESTORATIVE DENTISTRY.


COMMENTS ON THE INNERVATION OF THE TEETH.


BIOLOGIC CONSIDERATIONS IN THE SELECTION AND USE OF RESTORATIVE MATERIALS.


THE ROLE OF THE POSTERIOR FIXED BRIDGE IN OCCLUSION.


RELATIONSHIP OF CAVITY DESIGN TO RESTORATIVE MATERIALS.


DENTAL CEMENTS AND RESTORATIVE RESINS.

DENTAL CEMENTS AND RESTORATIVE RESINS.


DENTAL AMALGAM.

DENTAL AMALGAM.


EVALUATION OF MATERIALS USED FOR INDIRECT TECHNICS.


CASTING TECHNICS FOR SMALL CASTINGS.

CASTING TECHNICS FOR SMALL CASTINGS.


THE PORCELAIN FUSED TO METAL RESTORATION.


RESINS AND TECHNICS USED IN CONSTRUCTING DENTURES.


THE TILTED MOLAR ABUTMENT.

THE TILTED MOLAR ABUTMENT.


A RESTORATIVE APPROACH TO THE PERIODONTALLY TREATED MOUTH.


THE ANTERIOR THREE-QUARTER CROWN ABUTMENT PREPARATION AND RETAINER.


THE CEMENTATION OF CROWNS AND FIXED PARTIAL DENTURES.


THE FULL SHOULDER PREPARATION FOR PERIODONTAL HEALTH.


PHASE OF ALPHA BRAIN WAVES, REACTION TIME AND VISUALLY EVOKED POTENTIALS.


AVERAGED EVOKED ELECTROENCEPHALOGRAPHIC RESPONSES TO CLICKS IN THE HUMAN NEWBORN.


AUDITORY EVOKED RESPONSE COMPARISON DURING COUNTING CLICKS AND READING.


BEHAVIORAL AND ELECTROPHYSIOLOGICAL CHANGES DURING AVOIDANCE CONDITIONING TO LIGHT FLASHES IN THE RAT.


THE FAST COMPONENT IN THE ELECTRICAL ACTIVITY OF RABBIT'S HIPPOCAMPUS.


H-REFLEX AND EMG OF THE MENTAL AND HYOID MUSCLES DURING SLEEP, WITH SPECIAL REFERENCE TO NARCOLEPSY.


EVOKED RESPONSE FROM EXTRACRANIAL SITES IN THE CAT.


SERIAL EEG STUDY FOLLOWING THALAMOTOMY.

SERIAL EEG STUDY FOLLOWING THALAMOTOMY.


PYRIBENZAMINE ACTIVATION OF THE ELECTROENCEPHALOGRAM.


A MODULATOR FOR DISCRETE TRAINS OF PULSES.


ON THE EFFECT OF ANABOLISING ANDROGENS ON OSSEOUS SCAR FORMATION IN OLD, ADULT AND YOUNG RATS.


FACTORS WHICH INFLUENCE THE AGE-REACTION OF COLLAGEN IN THE SKIN.


RELATIONSHIP BETWEEN CANCER AND SENILE CHANGES IN THE LUNG, ELECTRON MICROSCOPY STUDY.


BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; CHANGE OF BLOOD CATALASE ACTIVITY UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC.


BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; CHANGE OF LIVER CATALASE ACTIVITY UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC.


BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; CHANGE OF SERUM MUCOPROTEIN LEVEL UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC.


BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; CHANGE OF SERUM CHOLINESTERASE ACTIVITY UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC.


BACTERIOSTATIC CHEMOTHERAPEUTIC AND MALIGNANT TUMOR GROWTH; HISTOCHEMICAL CHANGE OF HEPATIC SUCCINIC DEHYDROGENASE ACTIVITY UNDER PROLONGED ADMINISTRATION OF BACTERIOSTATIC CHEMOTHERAPEUTIC ON THE RATS.


EXPERIMENTAL STUDIES OF GROWTH-PROMOTING AND GROWTH-INHIBITING SUBSTANCES OF MALIGNANT TUMOR II. MITOSIS PROMOTING AND INHIBITING EFFECTS OF EXTRACTS FROM SUBCUTANEOUS EHRLICH ASCITES TUMOR AND VISCERAL ORGANS IN MICE.


ON THE INFLUENCES OF VARIOUS BACTERIA AND ENZYMES UPON COLD HEMAGGLUTININS (II) ON THE INFLUENCES OF VARIOUS BACTERIA AND THEIR ENZYMES.


URINARY ALDOSTERONE EXCRETION IN CIRRHOSIS OF LIVER WITH ASCITES AND ITS RELATIONSHIP WITH PLASMA VOLUME AND ELECTROLYTES.


CLINICO-PATHOLOGICAL STUDY OF PEPTIC ULCER IN HYDERABAD-DECCAN (A.P.): PATHOGENESIS AND PATHOLOGY.


RED CELL, PLASMA AND BLOOD VOLUME MEASURED BY RADIOCHROMIUM LABELLED CELLS AND HAEMATOCRIT IN INDIANS BELONGING TO LOW AND HIGH SOCIO-ECONOMIC GROUPS.


EXPERIMENTAL PANCREATITIS IN THE RHESUS MONKEY.


CERTAIN EPIDEMIOLOGICAL FEATURES OF PLAGUE IN UTTAR PRADESH: A STUDY IN RETROSPECT.


THE NATURAL HISTORY OF SCHIZOPHRENIA.

THE NATURAL HISTORY OF SCHIZOPHRENIA.


PSYCHODYNAMICS IN SCHIZOPHRENIA.

PSYCHODYNAMICS IN SCHIZOPHRENIA.


DIAGNOSIS OF SCHIZOPHRENIA: PSEUDONEUROTIC AND OTHER TYPES.


PSEUDONEUROTIC SCHIZOPHRENIA: CLINICAL COURSE AND SOCIAL OUTCOME.


PSYCHOLOGICAL DEFECT AND PSYCHOLOGICAL TESTING.


THE GENETIC APPROACH TO SCHIZOPHRENIA: CLINICAL, DEMOGRAPHIC, AND FAMILY GUIDANCE PROBLEMS.


CHILDHOOD SCHIZOPHRENIA.

CHILDHOOD SCHIZOPHRENIA.


THE MOTHERING PROCESS IN SCHIZOPHRENIA.

THE MOTHERING PROCESS IN SCHIZOPHRENIA.


PSYCHOTHERAPY WITH SCHIZOPHRENICS.

PSYCHOTHERAPY WITH SCHIZOPHRENICS.


THERAPEUTIC MILIEU FOR THE SERIOUSLY DISTURBED.


GROUP THERAPY IN SCHIZOPHRENIA.

GROUP THERAPY IN SCHIZOPHRENIA.


FAMILY THERAPY IN SCHIZOPHRENIA: THEORY AND PRACTICE.


PHARMACOLOGIC TREATMENT.

PHARMACOLOGIC TREATMENT.


NEUROPATHOLOGIC ASPECTS OF SCHIZOPHRENIA.


RESISTANCE OF COAGULASE-POSITIVE STAPHYLOCOCCI TO METHICILLIN AND OXACILLIN. Gravenkemper, Charles F. (University of Washington School of Medicine, Seattle), Jean L. Brodie, and William M. M. Kirby. Resistance of coagulase-positive staphylococci to methicillin and oxacillin. J. Bacteriol. 89:1005-1010. 1965.-Two strains resistant to methicillin were discovered among 541 strains of Staphylococcus aureus isolated in a clinical laboratory during a 1-yr period, and their properties were compared with those of strains isolated in Europe. The two strains were very active producers of penicillinase, and exhibited cross-resistance with other antistaphylococcal antibiotics. Like the European strains, our resistant cultures showed resistance to methicillin only with large inocula, and consisted of a mixture of cells. The great majority were sensitive and underwent early swelling and lysis, and only a small minority of the bacteria were able to grow in the presence of methicillin. The methicillin-resistant strains caused destruction of methicillin and oxacillin in vitro, but the rate of hydrolysis was slow. Antibiotic destruction was probably due to high concentrations of staphylococcal penicillinase, and not to another specific enzyme. These observations are helpful in explaining why resistance of staphylococci to the synthetic penicillins has not become a significant clinical problem.


UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS. Bodmer, Walter F. (Stanford University School of Medicine, Palo Alto, Calif.), and Susan Grether. Uptake and incorporation of thymine, thymidine, uracil, uridine, and 5-fluorouracil into the nucleic acids of Bacillus subtilis. J. Bacteriol. 89:1011-1014. 1965.-From 55 to 95% of uracil, uridine, or 5-fluorouracil (FU) added to the culture medium is incorporated into the acid-insoluble fraction of cells of Bacillus subtilis strains SB 19 (prototroph) and SB 503 (FU-resistant). Thymine is poorly incorporated (less than 1%); thus, the incorporation of thymidine is limited (less than 12%) by the rapid degradation of the nucleoside to thymine, probably by the enzyme thymidine phosphorylase. Uracil, uridine, and FU were not incorporated into the deoxyribonucleic acid (DNA) of either strain, whereas all the incorporated thymidine was found in the DNA.


NICKEL-DEPENDENT CHEMOLITHOTROPHIC GROWTH OF TWO HYDROGENOMONAS STRAINS. Bartha, R. (University of Washington, Seattle), and E. J. Ordal. Nickel-dependent chemolithotrophic growth of two Hydrogenomonas strains. J. Bacteriol. 89:1015-1019. 1965.-The trace element requirements for growth of facultative chemolithotrophic Hydrogenomonas strains H1 and H16 were investigated under both autotrophic and heterotrophic conditions. The organisms were grown in a mineral medium, rendered deficient in trace elements by extraction with 8-hydroxyquinoline and chloroform, and, in some cases, by coprecipitation with copper. The organic substrates, succinate and fumarate, used for heterotrophic growth were treated in a similar fashion. Acetate and butyrate were purified by redistillation. It was found that iron alone was required for heterotrophic growth (optimal concentration, 1.5 x 10(-6)m Fe(+++)), but cells grown chemolithotrophically on molecular hydrogen required the addition of nickel. The yield of protein was proportional to the nickel added, reaching a maximum at 3 x 10(-7)m Ni(++). Manganese, cobalt, copper, and zinc, alone or in combination, failed to substitute for nickel in the experiments with Hydrogenomonas. Although nickel is required specifically for the chemolithotrophic growth of Hydrogenomonas, nickel deficiency did not affect: (i) the synthesis or activation of hydrogenase, (ii) the Knallgas reaction, (iii) the assimilation of CO(2) by resting cells, or the synthesis of the storage material poly-beta-hydroxybutyric acid. It is suggested that nickel participates in some reaction involved in CO(2) fixation by growing cells.


COMPARISON OF LIPIDS AND LIPOPOLYSACCHARIDE FROM THE BACILLARY AND L FORMS OF PROTEUS P18. Nesbitt, J. A., III (The Johns Hopkins University School of Medicine, Baltimore, Md.), and W. J. Lennarz. Comparison of lipids and lipopolysaccharides from the bacillary and L forms of Proteus P18. J. Bacteriol. 89:1020-1025. 1965.-Comparative studies on the L form of Proteus P18 and the parent bacterium grown in a defined medium showed that the L form contained 1.5 times as much extractable lipid (dry weight) as the bacillary form. The composition of the lipids extractable by chloroform-methanol was quite similar in the two bacterial forms. The occurrence of myristate and beta-hydroxymyristate in the bound, nonextractable lipid was found to be a reflection of the presence of lipopolysaccharide (LPS) in each organism. The bacillary organism contains three to four times as much LPS as the L form. The LPS isolated from both organisms contains heptose, hexosamine, phosphorus, 3-deoxyoctulosonate, glucose, galactose, and fatty acids.


ENVIRONMENTAL CONTROL OF CELL COMPOSITION IN ESCHERICHIA COLI. Wright, D. N. (Iowa State University, Ames), and W. R. Lockhart. Environmental control of cell composition in Escherichia coli. J. Bacteriol. 89:1026-1031. 1965.-Escherichia coli was grown in continuous culture at various rates in a defined medium with either the carbon or the nitrogen source as rate-limiting substrate. Average cell size and the cellular content of ribonucleic acid, protein, and free amino acids varied both with growth rate and with the identity of the limiting nutrient, being greatest at high growth rates, and greater for nitrogen-limited than for carbon-limited populations. Immunoelectrophoresis of cell extracts revealed antigenic components associated uniquely with growth rate, and others associated with the identity of the limiting nutrient on which cells had been grown. Cell composition thus appears to reflect the physiological adjustment of a microbial population to its total environment.


X IRRADIATION OF A SENSITIVE AND A RESISTANT STRAIN OF ESCHERICHIA COLI UNDER CONTROLLED OXYGEN CONCENTRATIONS. van Soestbergen, A. A. (Brookhaven National Laboratory, Upton, N.Y.). X irradiation of a sensitive and a resistant strain of Escherichia coli under controlled oxygen concentrations. J. Bacteriol. 89:1032-1034. 1965.-Radiosensitive and radioresistant strains of Escherichia coli were given an X-ray dose of 4,544 rad at various controlled O(2) concentrations, and the results were subjected to probit analysis. A varkappa(2) test gave no evidence of heterogeneity of departure from fitted parallel probit lines obtained after plotting the probit of the surviving fractions of each of the two strains on the logarithm of the O(2) concentration. Under the conditions of the experiment, the ratio of the oxygen concentrations at which equal fractions of populations of E. coli B/r and E. coli B-s were killed by X irradiation was estimated to be about 4.4.


COUPLING OF PHOSPHORYLATION AND CARBON DIOXIDE FIXATION IN EXTRACTS OF THIOBACILLUS THIOPARUS. Johnson, Emmett J. (University of Mississippi Medical Center, Jackson), and Harry D. Peck, Jr. Coupling of phosphorylation and carbon dioxide fixation in extracts of Thiobacillus thioparus. J. Bacteriol. 89:1041-1050. 1965.-A cell-free system from Thiobacillus thioparus which fixes large quantities of C(14)O(2) in the presence of ribose-5-phosphate, adenosine triphosphate (ATP), and Mg(++) has been described. The specific activity (0.041 mumole of ribulose-1,5-diphosphate min(-1) mg(-1) protein) of the CO(2)-fixing system approaches that of green plants, and is further evidence for the importance of the role of carboxydismutase in the thiobacilli. In addition to ATP, adenosine diphosphate (ADP) and other nucleoside triphosphates served with varying degrees of effectiveness for the fixation of C(14)O(2). The ATP requirement for CO(2) fixation was partially replaced under aerobic conditions by a combination of SO(3) (=), PO(4) ( identical with), and adenosine monophosphate (AMP). Phosphorylation and CO(2) fixation were separated in time by first incubating SO(3) (=) and AMP aerobically, and then anaerobically introducing C(14)O(3) (=) and ribose-5-phosphate into the reaction mixture. During the first incubation, P(32)O(4) ( identical with) was esterified into nucleotides, mainly ADP, and in the second incubation C(14)O(2) was fixed, with the concomitant utilization of almost equal amounts of the esterified phosphate. These data provide the first in vitro evidence for the mechanism of the coupling of CO(2) fixation and phosphorylation in T. thioparus. The fixation of C(14)O(2) was shown to be almost completely inhibited by AMP. This inhibition was not due to the conversion of ATP to ADP by adenylic kinase, or to the binding of magnesium by the nucleotide. The inhibition was specific for AMP, since other mononucleotides, adenosine, and adenine did not inhibit. The AMP regulation of CO(2) fixation may represent a basic control mechanism in autotrophic metabolism.


CONVERSION OF D-BIOTIN TO BIOTIN VITAMERS BY LACTOBACILLUS ARABINOSUS. Birnbaum, Jerome (University of Cincinnati College of Medicine, Cincinnati, Ohio), and Herman C. Lichstein. Conversion of d-biotin to biotin vitamers by Lactobacillus arabinosus. J. Bacteriol. 89:1035-1040. 1965.-Saccharomyces cerevisiae utilizes d-biotin, biotin sulfoxide, and several vitamers of biotin, whereas Lactobacillus arabinosus responds to biotin and biotin sulfoxide of the naturally occurring forms of the vitamin. The use of these organisms for differential assay permitted investigation into possible conversion of d-biotin to vitamers of biotin by cells of L. arabinosus. Cells were grown in modified Wright-Skeggs medium containing several levels of biotin. No differences were detected between the assays for free intracellular or bound biotin up to 48 hr of growth. However, at 15 to 16 hr, in media containing an excess of biotin, the lactobacillus assay value for menstruum biotin dropped markedly, whereas the yeast assay showed no change. This suggested that biotin was converted to vitamers not active for L. arabinosus. The biotin-converting system appears to have characteristics of an enzyme system, i.e., a temperature optimum at 37 C, a broad pH optimum of 4.3 to 6.5, and requirements for Mg and Mn ions. Experiments suggest that increasing hydrogen ion concentration is a major physiological mechanism controlling the formation of this system. The vitamers were separated chromatographically and were found to have R(F) values of 0.44 and 0.94, and are combinable and uncombinable with avidin, respectively. The physiological role of biotin conversion is discussed in relation to control of cell populations in cultures of L. arabinosus.


PRELIMINARY ENZYMATIC EVENTS IN ASPARAGINE-DEPENDENT DENITRIFICATION BY PSEUDOMONAS PERFECTOMARINUS. Best, Audrey N. (University of Georgia, Athens), and W. J. Payne. Preliminary enzymatic events in asparagine-dependent denitrification by Pseudomonas perfectomarinus. J. Bacteriol. 89:1051-1054. 1965.-The initial events leading to denitrification by Pseudomonas perfectomarinus grown anaerobically in the presence of NO(3) (-) were investigated. Conversion of asparagine to malic acid was demonstrated. The nicotinamide adenine dinucleotide phosphate-linked malic acid dehydrogenase in this bacterium was shown to have a dependence for a divalent cation. A transhydrogenase was demonstrated. Oxaloacetic acid, a likely intermediate in conversion of malic to pyruvic acid, was rapidly decarboxylated by enzymes in cell-free extracts. We were not able to show reversible formation of malic acid with oxaloacetic acid and reduced nicotinamide adenine dinucleotide phosphate, nor of oxaloacetic acid with pyruvic acid and CO(2).


INCORPORATION OF C14 FROM CARBON DIOXIDE INTO SUGAR PHOSPHATES, CARBOXYLIC ACIDS, AND AMINO ACIDS BY CLOSTRIDIUM THERMOACETICUM. Ljungdahl, Lars (Western Reserve University, Cleveland, Ohio), and Harland G. Wood. Incorporation of C(14) from carbon dioxide into sugar phosphates, carboxylic acids, and amino acids by Clostridium thermoaceticum. J. Bacteriol. 89:1055-1064. 1965.-The mechanism of synthesis of acetate from carbon dioxide by Clostridium thermoaceticum was investigated by incubating cells with glucose or xylose in the presence of C(14)O(2). Sugar phosphates, amino acids, and carboxylic acids were isolated and the specific radioactivities were determined; the distributions of C(14) were also determined in some of the compounds. Only fructose-1,6-diphosphate, formate, and lactate had higher specific activities than the acetate. The specific activities and distribution of C(14) in the fructose-6-phosphate and ribose-5-phosphate were such that we conclude that the synthesis of acetate does not occur via a pathway involving the sugar phosphates as direct intermediates. Likewise, it is shown that pathways including lactate, aspartate, serine, glycine, malate, and succinate are not of importance in the synthesis of acetate from CO(2). The methyl group of free methionine was unlabeled and is not a precursor of the methyl group of acetate.


LOCALIZATION OF SPORE MARKERS ON THE CHROMOSOME OF BACILLUS SUBTILIS. Takahashi, I. (McMaster University, Hamilton, Ontario, Canada). Localization of spore markers on the chromosome of Bacillus subtilis. J. Bacteriol. 89:1065-1067. 1965.-Attempts were made to locate spore markers on the chromosome by determining the mapping distance of ery(r), str(r), phe, tyr, and ser markers to which the spore markers are closely linked. The results obtained indicated that locus sp N2-2 is located near the terminus and loci sp 170-2, sp H12-4, and sp 1 are distributed between the middle and the origin of the chromosome. These spore markers are not linked to each other. The above observation confirms our previous finding that in Bacillus subtilis spore markers are distributed randomly along the chromosome.


MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS. Goss, William A. (Sterling-Winthrop Research Institute, Rensselaer, N.Y.), William H. Deitz, and Thomas M. Cook. Mechanism of action of nalidixic acid on Escherichia coli. II. Inhibition of deoxyribonucleic acid synthesis. J. Bacteriol. 89:1068-1074. 1965.-Nalidixic acid was shown to inhibit specifically the synthesis of deoxyribonucleic acid (DNA) in Escherichia coli. Slight effects on protein and ribonucleic acid (RNA) synthesis were observed only at higher levels of drug or after prolonged incubation. The inhibition of DNA synthesis in E. coli 15TAU, as measured by incorporation of C(14)-labeled thymine, was observed after exposure to nalidixic acid for 10 min. Inhibition of the incorporation of C(14)-labeled uracil into RNA and C(14)-labeled l-arginine into protein (21 and 28% inhibition, respectively) was observed only after 60 min of exposure. When cultures of E. coli 15TAU were exposed to 3.0 mug/ml of nalidixic acid (slightly greater than the minimal growth inhibitory concentration), the incorporation of C(14)-labeled thymidine was inhibited 30 to 40% after 90 min. Nalidixic acid at 10 mug/ml, a lethal concentration, inhibited thymidine incorporation 72% during this period. Nalidixic acid at 1.0 mug/ml had no apparent effect on the incorporation of C(14)-labeled adenine or C(14)-labeled uracil into RNA of cultures of E. coli 198, a wild-type strain. However, incorporation of both bases into DNA was strongly inhibited after 60 min of exposure (66 and 69%, respectively). Nalidixic acid inhibited DNA replication during a single round of synthesis. In contrast with "thymineless death," nalidixic acid was not lethal to E. coli 15TAU during restricted RNA and protein synthesis (i.e., in a medium containing thymine but lacking arginine and uracil). We have shown also that this chemotherapeutic agent has little effect on the synthesis of protein or RNA required to initiate DNA replication. After 75 min of inhibition, the capacity of E. coli 15TAU to synthesize DNA in a medium containing thymine, arginine, and uracil may be restored by a simple filtration and washing process, indicating that the drug is not firmly bound. These studies leave little doubt that a primary action of nalidixic acid is the inhibition of the synthesis of DNA in E. coli.


DISTRIBUTION OF GRISEOFULVIN TAKEN UP BY MICROSPORUM GYPSEUM: COMPLEXES OF THE ANTIBIOTIC WITH CELL CONSTITUENTS. El-Nakeeb, Moustafa A. (Rutgers, The State University, New Brunswick, N.J.), and J. O. Lampen. Distribution of griseofulvin taken up by Microsporum gypseum: complexes of the antibiotic with cell constituents. J. Bacteriol. 89:1075-1081. 1965.-The griseofulvin-(4-methoxy-H(3)) accumulated by Microsporum gypseum was bound to fungal constituents. Mild procedures (hot-water or acetone extraction) removed between 40 and 60% of the total concentration of antibiotic. The remainder was recovered only after treatment with hot trichloroacetic acid followed by hot NaOH. The ratio of griseofulvin-H(3) in the water-soluble pool to that in the nucleic acid (soluble in hot trichloroacetic acid) and protein (soluble in NaOH) fractions was about 2:1:1, respectively. Only small amounts of radioactivity could be detected subsequent to hot-water extraction in the cold trichloroacetic acid extracts and in the cell-wall residues. Essentially all the activity in the soluble pool and in the nucleic acid extracts was chemically unchanged griseofulvin, much of which was present in various complexes, especially after long periods of incubation. One cannot be certain of the original form of all the radioactivity which was extracted in the protein fraction, because some degradation of the antibiotic occurred during the hot NaOH treatment. Nevertheless, a considerable amount of griseofulvin-H(3) was still present, and there had been no significant incorporation of radioactivity into the amino acid residues. It is probable, therefore, that the radioactivity in both protein and nucleic acid fractions represents complexes of the antibiotic with macromolecular components which were formed in vivo by the sensitive organisms.


EFFECTS OF GROWTH RATE AND LIMITING SUBSTRATE ON GLUCOSE METABOLISM IN ESCHERICHIA COLI. Wright, D. N. (Iowa State University, Ames), and W. R. Lockhart. Effects of growth rate and limiting substrate on glucose metabolism in Escherichia coli. J. Bacteriol. 89:1082-1085. 1965.-Escherichia coli was grown in continuous culture at various rates in a defined medium with either glucose of (NH(4))(2)SO(4) as the rate-limiting substrate. Cellular content of polysaccharide ("glycogen") is greater in cells grown under nitrogen limitation with glucose available in excess, and is greater in rapidly grown than in slowly grown cells. The ability of cells to carry on endogenous respiration, as measured by tetrazolium reduction, can be correlated with their glycogen content. In carbon-limited cultures, the proportion of substrate glucose diverted to glycogen production is least for cells grown slowly, which may reflect greater energy requirements for cell maintenance in such cultures. The activity of glucose-6-phosphate dehydrogenase (indicating function of a C-1 preferential pathway for glucose degradation) is greater in rapidly grown cells, confirming earlier observations in batch cultures. Activity of this enzyme is also greater in nitrogen-limited than in carbon-limited cells, suggesting that there may be catabolic repression of the Embden-Meyerhoff pathway when glucose is available in excess.


REVERSIBLE EFFECT OF BICARBONATE ON THE INHIBITION OF MYCOBACTERIAL AND YEAST TRANSGLUCOSYLASES BY MYCORIBNIN. Lornitzo, Frank A. (Veterans Administration Hospital, Madison, Wis.), and Dexter S. Goldman. Reversible effect of bicarbonate on the inhibition of mycobacterial and yeast transglucosylases by mycoribnin. J. Bacteriol. 89:1086-1091. 1965.-The transglucosylase which catalyzes the formation of trehalose-6-phosphate from uridine diphosphate (UDP)-glucose and glucose-6-phosphate was purified from cell-free extracts of Mycobacterium tuberculosis H37Ra. During the purification procedure, the transglucosylase loses its sensitivity to mycoribnin, an inhibitor also found in these extracts. Sensitivity of the transglucosylase to mycoribnin is regained when the bicarbonate concentration of either enzyme or mycoribnin preparations is reduced to about 0.01 mm; sensitivity to mycoribnin is lost when low concentrations (< 1 mm) of bicarbonate are present in the reaction mixture. Transglucosylase preparations retain their bicarbonate-induced insensitivity to mycoribnin after dilution to a bicarbonate concentration which is ineffective for the initial conversion to insensitivity. The transglucosylases of brewer's yeast and of physiologically young (9-day) H37Ra cells, previously reported as insensitive to mycoribnin, have been partially purified. If bicarbonate is excluded from these preparations, the transglucosylases become sensitive to mycoribnin; bicarbonate abolishes this sensitivity. The H37Ra transglucosylase is specific for UDP-glucose and glucose-6-phosphate as substrates. UDP-galactose does not serve as a glycosyl donor; galactose-6-phosphate, ribose-5-phosphate, and glucose-1-phosphate do not act as glucosyl acceptors. Oligoribonucleotide analogues of mycoribnin do not inhibit substantially the H37Ra transglucosylase.


SEROLOGICAL ANALYSES OF CELLULAR SLIME MOLD DEVELOPMENT. II. PREFERENTIAL LOSS, DURING MORPHOGENESIS, OF ANTIGENIC ACTIVITY ASSOCIATED WITH THE VEGETATIVE MYXAMOEBAE. Sonneborn, D. R. (Brandeis University, Waltham, Mass.), L. Levine, and M. Sussman. Serological analyses of cellular slime mold development. II. Preferential loss, during morphogenesis, of antigenic activity associated with the vegetative myxamoebae. J. Bacteriol. 89:1092-1096. 1965.-A major antigenic component of Dictyostelium discoideum (vegetative myxamoebae) is retained during morphogenesis up to the final stages of fruiting-body construction. It is found in the cells constituting the stalk of the mature fruit but is undetectable in the spores. The nature of the preferential loss of antigen from this cell contingent is unknown. Antiserum prepared against the vegetative myxamoebae is cytotoxic and reduces cell viability by several orders of magnitude at dilutions of about 1:100.


LIPID INCLUSIONS IN L CELLS ASSOCIATED WITH VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS INFECTION. Hardy, Frank M. (Fort Detrick, Frederick, Md.), and David Arbiter. Lipid inclusions in L cells associated with Venezuelan equine encephalomyelitis virus infection. J. Bacteriol. 89:1101-1103. 1965.-Venezuelan equine encephalomyelitis (VEE) virus has been shown to induce changes of lipid components within the L cell. Lipid inclusions in the form of dark granular bodies were observed in the L cell after aqueous osmium tetroxide fixation and Sudan black staining. Microscopic examination of cells as early as 8 hr after infection with VEE virus showed an increase in the concentration of these inclusions within the cytoplasm. According to various lipid solubility criteria, the inclusions were considered a combination of heterogeneous phospholipids.


DENITRIFICATION BY CORYNEBACTERIUM NEPHRIDII. Hart, Lewis T. (Louisiana State University, Baton Rouge), A. D. Larson, and C. S. McCleskey. Denitrification by Cornyebacterium nephridii. J. Bacteriol. 89:1104-1108. 1965.-Corynebacterium nephridii was found to reduce nitrate (contrary to the original description) at a rapid rate. In the conventional 0.1% nitrate broth, neither nitrite nor nitrate was detected after 24 hr. There was no assimilation of nitrate nitrogen, and the final product of nitrate reduction was nitrous oxide. Manometric studies and growth experiments indicated that the organism is incapable of reducing nitrous oxide. C. nephridii is gram-negative, grows on bile salts (5%) agar, EMB Agar, and MacConkey Agar. It was proposed that this species be transferrrd to the genus Achromobacter and designated Achromobacter nephridii (Büsing, Döll, and Freytag) comb. nov.


BIOCHEMICAL CHARACTERISTICS OF VIBRIO SPUTORUM AND RELATIONSHIP TO VIBRIO BUBULUS AND VIBRIO FETUS. Loesche, Walter J. (Forsyth Dental Center and Harvard School of Dental Medicine, Boston, Mass.), Ronald J. Gibbons, and Sigmund S. Socransky. Biochemical characteristics of Vibrio sputorum and relationship to Vibrio bubulus and Vibrio fetus. J. Bacteriol. 89:1109-1116. 1965.-Twenty-seven strains of Vibrio sputorum were isolated from human gingival debris. All strains reduced nitrate beyond nitrite, and all produced H(2)S. None produced catalase, indole, or acetylmethylcarbinol. Carbohydrates were not fermented, and acid end products or volatile neutral products could not be detected. Motility was observed infrequently, although 14-hr cultures usually had a few cells which displayed darting motility. Shadowed electron microscopic preparations demonstrated that most cells in a given culture were nonflagellated, although some cells with a single terminal or subterminal flagellum were always observed. V. sputorum was demonstrated not to be a strict anaerobe as previously described, but rather a microaerophile. Addition of nitrate to culture media markedly enhanced growth. V. sputorum was found to be closely related to the animal microaerophilic vibrios, V. bubulus and V. fetus. V. sputorum differed from V. fetus by being capable of anaerobic growth, producing H(2)S, and failing to produce catalase or to grow in 10% O(2). Antigens of V. sputorum cross-reacted in low titer with antisera to V. fetus serotypes I, II, III, and V. V. sputorum differed from V. bubulus by being inhibited by 3.5% NaCl and by qualitative differences in growth in the presence of 1% glycine and 10% O(2). These differences do not appear sufficient to recognize two distinct species, and it is proposed that both species be recognized as V. sputorum, which has priority. Strains unable to grow in 3.5% NaCl would be considered V. sputorum var. sputorum, whereas strains capable of growth in 3.5% NaCl would be V. sputorum var. bubulum.


BIOCHEMICAL EFFECTS OF NOVOBIOCIN ON STAPHYLOCOCCUS AUREUS. Wishnow, Rodney M. (Washington University School of Medicine, St. Louis, Mo.), Jack L. Strominger, Claire H. Birge, and Robert H. Threnn. Biochemical effects of novobiocin on Staphylococcus aureus. J. Bacteriol. 89:1117-1123. 1965.-Novobiocin induced accumulation in Staphylococcus aureus of uridine nucleotide precursors of the cell-wall glycopeptide, of a cytidine nucleotide precursor of the teichoic acid in the cell wall, and of a large number of other ultraviolet-absorbing materials. These substances accumulated promptly on addition of the antibiotic at levels near the growth-inhibitory concentration. Isotopic experiments showed that, in addition to inhibiting cell-wall synthesis, novobiocin also inhibited both protein and nucleic acid synthesis. The lack of selectivity in the action of novobiocin is similar to that previously observed with gentian violet, and is quite different from the selective inhibition of cell-wall synthesis observed with penicillin or with d-cycloserine. Although inhibition of cell-wall synthesis is not excluded as one of the primary lethal effects of novobiocin, it is also possible that all of the observed phenomena are secondary to some other primary metabolic lesion.


NUCLEOTIDE ACCUMULATION INDUCED IN STAPHYLOCOCCUS AUREUS BY GLYCINE. Strominger, Jack L. (Washington University School of Medicine, St. Louis, Mo.), and Claire H. Birge. Nucleotide accumulation induced in Staphylococcus aureus by glycine. J. Bacteriol. 89:1124-1127. 1965.-High concentrations of glycine induce accumulation of four uridine nucleotides in Staphylococcus aureus. Investigations of their structure suggest that these compounds are uridine diphosphate (UDP)-acetylmuramic acid, UDP-acetylmuramyl-gly-d-glu-l-lys, UDP-acetylmuramyl-l-ala-d-glu-l-lys and UDP-acetylmuramyl-gly-d-glu-l-lys-d-ala-d-ala. The mechanism by which glycine may induce uridine nucleotide accumulation and protoplast formation is discussed.


NODULATION FACTOR FOR RHIZOBIUM-LEGUME SYMBIOSIS. Valera, Concepcion L. (Cornell University, Ithaca, N.Y.), and M. Alexander. Nodulation factor for Rhizobium-legume symbiosis. J. Bacteriol. 89:1134-1139. 1965.-Nodulation of excised roots of Medicago sativa was enhanced by an extract of alfalfa seeds but not by several other substances. Coconut water exerted a similar influence upon the formation of nodules on excised roots of Glycine max and Phaseolus vulgaris. Direct evidence for a host factor concerned in nodule genesis was obtained by demonstrating that, although P. vulgaris seedlings developing from embryos devoid of cotyledons nodulated in the presence of an infective Rhizobium strain, nodules did not appear on explants derived from hypocotyls obtained from ungerminated seed. The legume factor, when examined by a soybean hypocotyl bioassay procedure, could be replaced by a water-soluble, thermostable, dialyzable fraction of coconut water, but not by meso-inositol, scyllitol, sorbitol, yeast extract, or a number of amino acids.


FINE STRUCTURE OF REOVIRUS TYPE 2.

FINE STRUCTURE OF REOVIRUS TYPE 2. Loh, Philip C. (University of Hawaii, Honolulu), H. R. Hohl, and M. Soergel. Fine structure of reovirus type 2. J. Bacteriol. 89:1140-1144. 1965.-The fine structure reovirus type 2 was studied by electron microscopy with the negative-staining method. The virus has a mean diameter of 772 A and shows evidence of icosahedral shape and 5:3:2 symmetry. The particle is composed of a core, an inner layer, and a capsid composed of 92 elongated hollow capsomeres. These capsomeres have mean dimensions of 116 A x 110 A and a central hole 48 A in diameter. In size and architecture, reovirus type 2 is very similar to the other members (reoviruses types 1 and 3) of this group of animal viruses.


GLYCINE SYNTHESIS AND METABOLISM IN ESCHERICHIA COLI. Pizer, Lewis I. (University of Pennsylvania, Philadelphia). Glycine synthesis and metabolism in Escherichia coli. J. Bacteriol. 89:1145-1150. 1965.-A correlation was demonstrated between a nutritional requirement that can only be satisfied by glycine and the absence of the enzymatic capacity to interconvert l-serine and glycine. Serine synthesis from 3-phosphoglycerate was observed in the same cell-free extracts which could not convert serine to glycine. The above results show that serine is the precursor of glycine under normal growth conditions. The C-2 of glycine provided "one-carbon" fragments when the C-3 of serine was not available as the source of "one-carbon" fragments. This condition occurred when a mutation produced a loss of serine aldolase activity or when a serine-glycine auxotroph was grown with glycine. Under these growth conditions, 30 to 40% of the "one-carbon" fragments used for cellular synthesis were derived from glycine.


FORMATION OF SPHEROPLASTS FROM BACILLUS ANTHRACIS. Chatterjee, B. R. (Baylor University College of Medicine, Houston, Tex.), and Robert P. Williams. Formation of spheroplasts from Bacillus anthracis. J. Bacteriol. 89:1128-1133. 1965.-Spheroplasts were prepared from Bacillus anthracis by combined treatment with lysozyme and glycine. Glycine, at a final concentration of 3%, was added to cultures of B. anthracis in nutrient broth that had grown at 37 C for 16 to 18 hr under 50% CO(2). After additional incubation under CO(2) for 2 hr, lysozyme, at the appropriate concentration (50 to 100 mug/ml), and sucrose, to a concentration of 15%, were added, and incubation was continued for 2 to 6 hr in CO(2). At the end of this period, incubation in CO(2) was discontinued. Spheroplasts formed after incubation in air for 6 to 12 hr. Lysozyme alone exhibited the same effect when added at much higher concentrations (500 to 2,000 mug/ml) to cultures growing under CO(2). No spheroplasts formed when cultures were treated with glycine alone. Treatment with lysozyme was more effective on smooth strains than rough. Cells from young cultures were more susceptible to lysozyme than older cells. CO(2) apparently was essential for formation of spheroplasts from B. anthracis.


PLASMOLYSIS IN BACILLUS MEGATERIUM.

PLASMOLYSIS IN BACILLUS MEGATERIUM. Weibull, Claes (Central Bacteriological Laboratory of Stockholm City, Stockholm, Sweden). Plasmolysis in Bacillus megaterium. J. Bacteriol. 89:1151-1154. 1965.-Sucrose solutions stronger than 1 m caused plasmolysis in Bacillus megaterium strain M, whereas concentrated NaCl and KNO(3) solutions were ineffective. In plasmolyzed cells, mesosome bodies were found in pockets between the cytoplasmic membrane and the cell wall. After plasmolysis, the cytoplasmic membrane appeared as a triple-layered structure, a "unit membrane." Plasmolysis did not markedly influence the viability of the cells.


IMMUNOFLUORESCENT DEMONSTRATION OF CELL-ASSOCIATED STAPHYLOCOCCAL ENTEROTOXIN B.


PARTIAL SATISFACTION OF A URACIL REQUIREMENT BY 5-FLUOROURACIL.


CYSTINE DEPENDENCE OF THERMORESISTANT MUTANTS OF POLIOVIRUS.


BIOSYNTHESIS OF VALINE IN STREPTOMYCIN-DEPENDENT ESCHERICHIA COLI.


CONTAMINATION OF COMMERCIAL L-LEUCINE PREPARATIONS WITH METHIONINE AND CYSTINE.


BETA-GALACTOSIDASE OF STREPTOCOCCUS LACTIS. Citti, J. E. (Oregon State University, Corvallis), W. E. Sandine, and P. R. Elliker. beta-Galactosidase of Streptococcus lactis. J. Bacteriol. 89:937-942. 1965.-Synthesis of beta-galactosidase by several strains of Streptococcus lactis was induced by lactose. The rate of hydrolysis of o-nitrophenyl-beta-d-galactopyranoside was used to measure enzyme activity. The enzyme of all but one strain was unstable when whole cells were sonic-treated or treated with toluene; the enzyme of one strain of S. lactis was stable to these treatments, which resulted in at least a fivefold increase in activity over that found in whole cells. The optimal assay conditions for toluene-treated cells of this strain involved incubation at 37 C in pH 7.0 sodium phosphate buffer. Lactose was the most effective inducer of enzyme synthesis. Methyl-beta-d-thiogalactopyranoside, isopropyl-beta-d-thiogalactopyranoside, and galactose were also inducers of the enzyme, but were not as effective as lactose. Melibiose, maltose, and calcium lactobionate were poor inducers of enzyme synthesis. Exogenously supplied glucose repressed enzyme synthesis. The means of control of induced beta-galactosidase synthesis in S. lactis was similar to that in Escherichia coli.


EFFECT OF HEAT AND PLATING MEDIUM ON SURVIVAL OF ESCHERICHIA COLI AFTER TREATMENT WITH RADIOMIMETIC CHEMICALS. Zampieri, Antonio (Palo Alto Medical Research Foundation, Palo Alto, Calif.), and Joseph Greenberg. Effect of heat and plating medium on survival of Escherichia coli after treatment with radiomimetic chemicals. J. Bacteriol. 89:931-936. 1965.-Survival of Escherichia coli strain S and its radioresistant mutant R(4) after treatment with mitomycin C, azaserine, nitrogen mustard, 1-methyl-3-nitro-1-nitrosoguanidine, nitrofurazone, and proflavine was studied. With all agents except proflavine, R(4) was more resistant than was S. Survival of strain S was greater on minimal glucose-salts medium than on Penassay (Difco), and greater on the latter than on Tryptone (Difco) agar; survival of S was greater when posttreatment incubation temperature was 45 C than when it was 37 C. Post-treatment plating medium or temperature had no effect on survival of R(4). Visible light did not affect survival of S or R(4). The survival curves of R(4) were exponential; those of S exhibited decreasing sensitivity with time of exposure. With proflavine, photoactivation by visible light was demonstrable, but there was no difference in survival between S and R(4). Survival of either strain was not affected by post-treatment plating medium or incubation temperature.


TYPE-SPECIFIC ANTIGENS IN THE PSITTACOSIS-LYMPHOGRANULOMA VENEREUM GROUP OF ORGANISMS. Fraser, C. E. Ovid (University of Wisconsin, Madison), and David T. Berman. Type-specific antigens in the psittacosis-lymphogranuloma venereum group of organisms. J. Bacteriol. 89:943-948. 1965.-Antigens of 14 strains of the psittacosis-lymphogranuloma venereum (PLV) group of organisms were prepared by treating purified particles with deoxycholate and trypsin. In complement-fixation tests of these antigens with the homologous and heterologous antisera, specific serotype differences were observed. Application of the method of specificity differences permitted placement of the 14 strains into 7 subgroups. The possible value of these techniques in immunology, epizootiology, and taxonomy of the PLV group is discussed.


EGG YOLK FACTOR OF STAPHYLOCOCCUS AUREUS. II. CHARACTERIZATION OF THE LIPASE ACTIVITY. Shah, D. B. (University of Wisconsin, Madison), and J. B. Wilson. Egg yolk factor of Staphylococcus aureus. II. Characterization of the lipase activity. J. Bacteriol. 89:949-953. 1965.-The staphylococcal egg yolk factor was characterized as a lipase. The enzyme had an optimal pH of 7.8, but the optimal pH of stability was 7. Substrate specificity data showed that the relative rate of hydrolysis was lowest with triacetin as substrate, was maximal with tributyrin, and decreased as the chain length of the acyl moieties increased. The enzyme showed an absolute requirement for a fatty acid acceptor like calcium, when the acyl moiety of triglyceride was water-insoluble. Magnesium, strontium, and barium functioned equally well as fatty acid acceptors. The enzyme was able to hydrolyze coconut oil, peanut oil, olive oil, and egg yolk oil.


POLYOL METABOLISM IN THE BASIDIOMYCETE SCHIZOPHYLLUM COMMUNE. Niederpruem, Donald J. (Indiana University Medical Center, Indianapolis), Amtul Hafiz, and Lyle Henry. Polyol metabolism in the basidiomycete Schizophyllum commune. J. Bacteriol. 89:954-959. 1965.-The polyol metabolism of intact cells and extracts of the wood-rotting mushroom Schizophyllum commune was investigated during the developmental cycle. Exogenous polyols stimulated the cellular respiration of germlings, but were without effect on that of ungerminated basidiospores. Requisite enzymes of polyol metabolism were demonstrated in extracts of spores and of subsequent stages of development. Oxidation of mannitol and sorbitol appeared to be coupled to nicotinamide adenine dinucleotide (NAD) reduction and was favored in alkaline medium. Ketohexose formation was shown during mannitol oxidation, and the NAD-dependent oxidation of xylitol yielded ketopentose. Xylitol oxidation with nicotinamide adenine dinucleotide phosphate (NADP) as hydrogen acceptor led to pentose formation. Oxidation of reduced NAD was enhanced by fructose but not by sorbose. Reduction of aldohexose and pentose was dependent upon reduced NADP, and pentose reductase was maximal at pH 6.8. The specific activity of mannitol dehydrogenase was highest in extracts of vegetative mycelium. Growth in either glucose or xylose media had no significant effect on enzymes of polyol metabolism.


DRUG RESISTANCE OF STAPHYLOCOCCI. I. TRANSDUCTION OF TETRACYCLINE RESISTANCE WITH PHAGE LYSATES OBTAINED FROM MULTIPLY RESISTANT STAPHYLOCOCCI. Mitsuhashi, Susumu (Gunma University, Maebashi, Japan), Hiroshi Oshima, Umeko Kawaharada, and Hajime Hashimoto. Drug resistance of staphylococci. I. Transduction of tetracycline resistance with phage lysates obtained from multiply resistant staphylococci. J. Bacteriol. 89:967-976. 1965.-Tetracycline resistance was found to be transduced with phage lysates obtained from multiply resistant strains of Staphylococcus aureus of human origin. With various combinations of multiply resistant donors and tetracycline (TC)-sensitive recipients, almost all of the strains were found to be competent donors. A greater percentage of group 1 staphylococci were competent recipients. Most of the TC(+) transductants were not lysogenic for the transducing phage and were unable to transduce TC resistance with their own phage lysates obtained by ultraviolet irradiation. However, the TC(+) transductants, lysogenized with transducing phage, were capable of transducing TC resistance, and some of the lysogenizations were accompanied by changes in phage type. These results suggest that the emergence of the multiply resistant staphylococci (consistently resistant to TC) can be accounted for by transduction among various strains accompanied sometimes by changes in phage typing pattern after lysogenization, and by selection through extensive use of antibiotics and chemotherapeutic agents.


RELEASE OF NITROGENOUS SUBSTANCES BY BREWER'S YEAST. IV. ENERGETICS IN SHOCK EXCRETION OF AMINO ACIDS. Lewis, M. J. (University of California, Davis), and H. J. Phaff. Release of nitrogenous substances by brewer's yeast. IV. Energetics in shock excretion of amino acids. J. Bacteriol. 89:960-966. 1965.-When suitably grown yeast cells are suspended in a solution of fermentable sugar, amino acids from the internal pool are rapidly released from the cells, a phenomenon referred to as shock excretion. After approximately 2 to 3 hr, in the presence of excess sugar, the amino acids are almost completely reabsorbed. This observation has been further studied with particular reference to the energy-yielding reactions of the cell. It has been established that amino acid release increases more rapidly with a rise in incubation temperature than does fermentation rate. Amino acid release cannot be inhibited by the common uncouplers of adenosine triphosphate synthesis (azide, arsenate, or 2,4-dinitrophenol) at concentrations adequate to prevent reabsorption of amino acids-an energy-requiring event. Inhibitors which completely inhibit the dissimilation of glucose (such as iodoacetate and fluoride) or those preventing entry of glucose into the cell (uranyl acetate) are effective in preventing amino acid release. It was concluded that shock excretion of amino acids is independent of energy-yielding reactions, but may be the result of changes in the state of the cell contingent upon the continuous flow of a fermentable sugar across the cell membrane.


PROFLAVINE INHIBITION OF VACCINIA VIRUS SYNTHESIS. Bubel, H. Curt (University of Cincinnati College of Medicine, Cincinnati, Ohio), and David A. Wolff. Proflavine inhibition of vaccinia virus synthesis. J. Bacteriol. 89:977-983. 1965.-The synthesis of vaccinia virus, hemagglutinin, and blocking antigen, as well as the development of cytopathic effects, were inhibited by low concentrations of proflavine. This inhibitor did not exert a selective effect on any particular portion of the virus synthetic cycle. Proflavine added to infected KB cells during the eclipse period or later stages of virus maturation rapidly arrested further production of infectious virus and virus-related products. Suppression of virus synthesis was completely reversible, indicating that permanent damage to the virus synthetic mechanism did not result from a transient exposure to proflavine. Photosensitization of maturating vaccinia virus by subinhibiting concentrations of proflavine suggested an interaction of the inhibitor with viral nucleic acid.


ULTRAVIOLET-ABSORPTION SPECTRA OF DRY BACTERIAL SPORES. Bailey, Glen F. (Western Regional Research Laboratory, Albany, Calif.), Saima Karp, and L. E. Sacks. Ultraviolet-absorption spectra of dry bacterial spores. J. Bacteriol. 89:984-987. 1965.-The possibility of obtaining reasonably satisfactory ultraviolet-absorption spectra of dry spores embedded in KBr has been demonstrated. Such spectra show the three peaks characteristic of calcium dipicolinate. The dipicolinate spectra are more distinct when reference pellets containing appropriate amounts of the analogous spore coats are employed. These spectra are considered evidence that some type of calcium-dipicolinic acid chelate accounts for at least part of the calcium and dipicolinic acid content of the spore.


DRUG RESISTANCE OF STAPHYLOCOCCI. II. JOINT ELIMINATION AND JOINT TRANSDUCTION OF THE DETERMINANTS OF PENICILLINASE PRODUCTION AND RESISTANCE TO MACROLIDE ANTIBIOTICS. Mitsuhashi, Susumu (Gunma University, Maebashi, Japan), Hajime Hashimoto, Megumi Kono, and Masato Morimura. Drug resistance of staphylococci. II. Joint elimination and joint transduction of the determinants of penicillinase production and resistance to macrolide antibiotics. J. Bacteriol. 89:988-992. 1965.-Strains of Staphylococcus aureus, which show high resistance to macrolide antibiotics (erythromycin, oleandomycin, leucomycin, and spiramycin) and the capacity to produce penicillinase, have been isolated from clinical sources. The determinants of penicillinase production (PCase(+)) and resistance to macrolide antibiotics (MAC(r)) of these strains were irreversibly eliminated by treatment with acridine or with ultraviolet light. Among the 18 strains tested, PCase(+) and MAC(r) were eliminated from all strains except one, which lost only PCase(+) but not MAC(r). The characters PCase(+) and MAC(r) were jointly transduced with the aid of phage lysates, obtained from the resistant donors by ultraviolet irradiation, into staphylococcal strains sensitive to PC and MAC. Segregation of PCase(+) and MAC(r) was rarely observed after transduction. From these results, it is suggested that the determinants of both PCase(+) and MAC(r) of staphylococci are located close together on a single genetic element, i.e., a plasmid (or episome), which exists extrachromosomally.


REPRESSION OF TRYPTOPHANASE SYNTHESIS IN ESCHERICHIA COLI. Beggs, William H. (University of Cincinnati, Cincinnati, Ohio), and Herman C. Lichstein. Repression of tryptophanase synthesis in Escherichia coli. J. Bacteriol. 89:996-1004. 1965.-The nature of the glucose effect on tryptophanase in Escherichia coli (Crookes) was investigated to test the catabolite-repression hypothesis. Under static conditions of growth in the presence of 0.005 m glucose, tryptophanase was repressed and remained so upon continued static incubation subsequent to glucose exhaustion. Aeration following glucose exhaustion under static cultural conditions resulted in rapid enzyme synthesis. In the absence of glucose, certain amino acids repressed tryptophanase synthesis early in the growth cycle under aerated conditions. An inverse relationship was observed between the concentration of acid-hydrolyzed casein and the level of tryptophanase. At 3 hr, enzyme activity in cells grown in media containing 0.05% acid-hydrolyzed casein was at least five times that of cells grown in the presence of 1% casein. Addition of 0.005 m d- or l-serine to a 0.05% acid-hydrolyzed casein medium rendered the medium capable of strongly repressing tryptophanase. Glucose-expended medium was prepared by allowing cells to grow and exhaust glucose in static culture. When this expended medium was recovered and inoculated with fresh cells not previously exposed to glucose, tryptophanase synthesis was repressed for a short period in shake culture, but in static culture enzyme synthesis was only slightly affected. When the expended medium was prepared from shake cultures, fresh cells were not repressed strongly when subsequent incubation was carried out aerobically. The tryptophan pool in glucose-repressed cells grown in shake culture was appreciably less than in cells grown in the absence of glucose or in cells undergoing synthesis of tryptophanase after exhaustion of the sugar.


CHARACTERIZATION OF ANTIBODIES IN HUMAN URINE.


LOCALIZATION AND PYRAZINAMIDE INHIBITION OF DISTAL TRANSTUBULAR MOVEMENT OF URIC ACID-2-C14 WITH A MODIFIED STOP-FLOW TECHNIQUE.


N15 TRACER STUDIES ON THE ORIGIN OF URINARY AMMONIA IN THE ACIDOTIC DOG, WITH NOTES ON THE ENZYMATIC SYNTHESIS OF LABELED CLUTAMIC ACID AND GLUTAMINES.


STUDIES OF THE EFFECTS OF ADMINISTRATION OF ACTH AND ADRENAL CORTICOSTEROIDS ON ERYTHROPHAGOCYTOSIS.


INTESTINAL ABSORPTION OF BILE PIGMENTS. 3. THE ENTEROHEPATIC CIRCULATION OF UROBILINOGEN IN THE RAT.


LEUKOKINETIC STUDIES. X. BLOOD GRANULOCYTE KINETICS IN CHRONIC MYELOCYTIC LEUKEMIA.


LEUKOKINETIC STUDIES. XI. BLOOD GRANULOCYTE KINETICS IN POLYCYTHEMIA VERA, INFECTION, AND MYELOFIBROSIS.


MODIFICATION OF THE ANTIDIURETIC EFFECT OF VASOPRESSIN BY ACID AND ALKALINE LOADS.


FUNCTIONAL SIGNIFICANCE OF A LOW PULMONARY DIFFUSING CAPACITY FOR CARBON MONOXIDE.


EFFECT OF D-ALDOSTERONE ON SALT AND WATER ABSORPTION FROM THE INTACT HUMAN COLON.


ROLE OF PLATELET FIBRINOGEN IN THE REACTIONS OF PLATELETS TO THROMBIN.


THE MECHANISM OF THE FRUCTOSE EFFECT ON THE ETHANOL METABOLISM OF THE HUMAN LIVER.


THE POTENTIAL ROLE OF INHALATION THERAPY EQUIPMENT IN NOSOCOMIAL PULMONARY INFECTION.


THE INFLUENCE OF BACTERIOCINS ON RESISTANCE TO INFECTION BY GRAM-NEGATIVE BACTERIA. I. THE EFFECT OF COLICIN ON BACTERICIDAL POWER OF BLOOD.


THE ROLE OF CARNITINE IN ACETOACETATE PRODUCTION AND FATTY ACID SYNTHESIS.


THE LIVER AND POSTHEPARIN PLASMA LIPOLYTIC ACTIVITY IN DOG AND MAN.


STUDIES OF THE INSULIN-INHIBITORY EFFECT OF HUMAN ALBUMIN FRACTIONS.


GIANT CONDYLOMA ACUMINATA: INCIDENCE AMONG CASES DIAGNOSED AS CARCINOMA OF THE PENIS. Twenty-four cases of giant condyloma acuminata were found among 100 cases diagnosed as carcinoma of the penis. One of the 24 tumours showed early malignant change. The characteristic histological pattern of giant condyloma consists of broad processes composed of prickle cells associated with little keratinization. The malignant condylomas show, in comparison, a loss of prickle cell preponderance, increased basal cell activity and frequent keratinization, or may present as a solid papillary epithelioma forming broad sheets of uniform cells with many mitoses. The incidence of malignant change in the giant condyloma and the relationship between the benign and malignant tumours are discussed.


RETROGRESSION IN TESTICULAR SEMINOMA WITH VIABLE METASTASES. Stages in the retrogression of testicular seminoma are described. Eosinophilic necrosis fringed by palisaded histiocytes may be followed by fibrous replacement. Oxidation of unsaturated phospholipids in necrotic tumour may lead to deposition of lipofuscin around the lesion. Search for partially or completely scarred lesions is essential before contemplating a diagnosis of primary retroperitoneal seminoma. Retrogressed seminoma can often be distinguished from retrogressed teratoid tumours. Apparently paradoxical teratoid metastases in association with a testicular seminoma are explained on the basis of misinterpreted retrogressed teratoid tumours in association with the seminoma. Inguinal node metastases from testicular seminoma may be the result of abnormal lymphatic drainage following previous scrotal operations, testicular torsion etc.


SYSTEMIC WEBER-CHRISTIAN DISEASE.

SYSTEMIC WEBER-CHRISTIAN DISEASE. A patient suffering from Weber-Christian panniculitis was found at necropsy to have similar lesions in the visceral adipose tissue. When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from Weber-Christian panniculitis should be investigated bearing in mind the possibility of internal lesions. Only 11 cases confirmed by necropsy appear to have been reported hitherto. The aetiology remains obscure. It is suggested that the name ;systemic Weber-Christian disease' be applied when the lesions occur in adipose tissue other than the panniculus adiposus and that the term ;Weber-Christian panniculitis' be used when the lesions are confined to the subcutaneous adipose tissue.


BRONCHIAL CARCINOMA IN AN OVARIAN CYSTIC TERATOMA (DERMOID). An ovarian cystic teratoma (dermoid) in which a squamous cell carcinoma had developed from bronchial epithelium via a process of basal cell hyperplasia, squamous metaplasia, and malignant change in situ is described. It is suggested that this sequence of changes may be due to the carcinogenic action of a constituent of the cyst contents.


CHROMOSOME ABNORMALITIES IN NEUROBLASTOMA. The case is briefly reported of a 7-month-old boy with a disseminated neuroblastoma, whose marrow showed neuroblastoma rosettes and on direct examination on two occasions revealed a high proportion of cells with 48 chromosomes forming an abnormal cell line.


TWO CASES OF CLOSTRIDIAL HEPATITIS.

TWO CASES OF CLOSTRIDIAL HEPATITIS. Two cases are described in which clostridial invasion of the liver and spleen was noted at post-mortem examination. In each there was a history of debilitating disease and it is suggested that the infection was consequent upon impaired immunological and cellular defence mechanisms.


RELATIONSHIP BETWEEN THE BLOOD LEVELS OF CHOLESTEROL, MUCOPROTEINS, AND FIBRINOGEN IN ISCHAEMIC HEART DISEASE. Serum cholesterol, serum mucoproteins, and plasma fibrinogen levels were estimated in 60 male patients with ischaemic heart disease. No correlation was found between the levels of these blood components.


LIGHT AND ELECTRON MICROSCOPE APPEARANCES IN RENAL BIOPSY MATERIAL FROM CASES OF RECURRENT HAEMATURIA IN CHILDREN.


ULTRASTRUCTURAL STUDIES OF HUMAN CUTANEOUS NERVE WITH SPECIAL REFERENCE TO LAMELLATED CELL INCLUSIONS AND VACUOLE-CONTAINING CELLS. One hundred and twenty-nine specimens of human cutaneous nerve obtained from patients suffering from a variety of neuromuscular disorders have been surveyed in detail by electron microscopy. The most striking finding was the presence of lamellated Schwann cell inclusions and of cells containing vacuoles, both of which appear to be derived from myelin and to show some correlation with sensory loss.


INDIRECT FLUORESCENT ANTIBODY TECHNIQUE IN THE SEROLOGY OF TOXOPLASMA GONDII. The indirect fluorescent antibody technique has been used to titrate patients' antibody against Toxoplasma gondii. Rigorous tests of the immunological validity of the method were made. The reactions of the gamma globulin of human immune serum with Toxoplasma gondii and fluorescent rabbit anti-human gamma globulin were thus shown to be specific. Thereafter the technique could be used with confidence to detect the reaction between doubling dilutions of patient's serum and smears of unfixed Toxoplasma gondii. In this way, titres were obtained with the indirect fluorescent antibody technique which agreed well with those of the dye test at both low and high levels of antibody. Compared with the dye test, the indirect fluorescent antibody technique has many advantages. The end-point is sharp and obviates the counting of stained and unstained organisms; supplies of antibody-free accessory factor sera are not needed; prozones undetected by the dye test are strongly positive at screening dilutions, the reagents keep indefinitely and lend themselves to preparation, standardization, and issue by a central reference laboratory.


PYOCINE TYPING OF PSEUDOMONAS AERUGINOSA. The growth-inhibitory effect of a small group of different pyocines has been used to differentiate Ps. aeruginosa isolates. A method is described which can be carried out with ordinary media and is easy for routine application. One hundred and one isolates of Ps. aeruginosa were differentiated by four pyocines into 10 pyocine patterns.


PLASMA TRAPPING IN THE CENTRIFUGED RED CELLS OF CHILDREN WITH SEVERE THALASSAEMIA. The amount of trapped plasma, expressed as a percentage of the packed cell volume, was determined in samples of heparinized blood from 26 children with severe thalassaemia and from 37 normal children over a wide range of artificial packed cell volumes. There was invariably more plasma trapped among the centrifuged red cells of the thalassaemic children, the mean difference between normal and thalassaemic children being 1% of the packed cell volume. In both normal and thalassaemic children the volume of trapped plasma, expressed as a percentage of the packed cell volume, was directly proportional to the packed cell volume. Plasma trapping did not appear to be related to the size of the erythrocytes in either the normal or the thalassaemic children. It varied inversely with the density of the red cells, as estimated by their mean haemoglobin concentration, in the thalassaemic children.


BIOCHEMICAL STUDIES ON HEPATIC INVOLVEMENT IN INFECTIOUS MONONUCLEOSIS. Eighty cases of infectious mononucleosis have been investigated by serum enzyme studies and other liver function tests. Maximum abnormalities occurred between the second and fourth weeks of illness and all tests were usually normal by the sixth week. Serum isocitric dehydrogenase activity was increased in 93% of cases and serum glutamic-oxaloacetic transaminase in 74%. Conventional liver function tests were less sensitive. Serum bilirubin was above normal in 40% of cases; in 17% of cases the increase was sufficient to show as clinical jaundice. No patient has developed chronic hepatitis.


AUTO-AGGLUTINATION IN ALBUMIN.

AUTO-AGGLUTINATION IN ALBUMIN. An example of the ;albumin' auto-agglutinating phenomenon is reported. This was found in the serum of a man dying from carcinoma of the stomach with liver secondaries. It is suggested that the serum factor is of a protein (probably globulin) nature, and may have been produced by the diseased liver.


INBORN ENZYMATIC DEFECT AS THE PROBABLE CAUSE OF THE FORMATION OF RENAL STONES CONSISTING OF URIC ACID. In four persons of one family the existence of an enzymatic defect, presumably consisting of a deficiency of glutaminase in the cells of the renal tubules, is postulated, and is implied by a reduced elimination of ammonia in the urine, by a relatively low urinary pH, and by its increased titratable acidity. The most characteristic clinical symptom is irritation of the distal part of the urinary tract, connected with numerous crystals of uric acid appearing in the urinary sediment. The elimination of uric acid is normal, or even reduced, and the level of uric acid in the blood serum is also within normal limits. After the administration of glutaminic acid elimination of ammonia is further decreased and the quantity of uric acid crystals is increased. Loading with glutaminic acid may also cause an attack of renal pain in the individual suffering from this defect but the administration of ammonium chloride does not cause any increase in ammonia production. It seems probable that the enzymatic defect is connected with the presence of antigen B in the erythrocytes and that it is inherited as a dominant autosomal feature. A suitable diet to make the urine alkaline allows kidneys to function efficiently in individuals suffering from this defect.


DETECTION OF FORMIMINO-GLUTAMIC AND UROCANIC ACIDS IN URINE BY MEANS OF THIN-LAYER CHROMATOGRAPHY. A simple and rapid method has been developed for the simultaneous separation and semi-quantitative estimation of formimino-glutamic and urocanic acids in urine. The urinary excretion of these compounds in a group of normal subjects and in a number of illustrative cases has been determined. In view of current opinion that it is the total of these two metabolites of histidine which is the significant figure in clinical investigation, their simultaneous separation and measurement is an important advantage of the method.


TWO CASES OF PRIMARY OXALOSIS.

TWO CASES OF PRIMARY OXALOSIS. Two patients, aged 66 and 62 years, are described who suffered from unilateral anuria and contralateral stone formation due to primary oxalosis. The diagnosis was established by microscopical examination of necropsy material in the first patient and by renal biopsy in the second and was confirmed by chemical and x-ray investigation of tissues and calculi. The sequence of events leading to the rather sudden precipitation of oxalate in the tissues is discussed, and a tentative explanation for the unilateral anuria is offered.


URINARY AMINO-ACETONE EXCRETION IN LEAD WORKERS. Urinary amino-acetone concentrations were determined in a group of 51 persons with industrial exposure to lead and the findings compared with those obtained from a control group of 27 persons having no exposure to lead.A good correlation was found between delta-aminolaevulinic acid and amino-acetone excretion in the control group but this correlation was not so well defined in the lead-exposed group. In this group excretion of amino-acetone seemed to be better correlated with excretion of delta-aminolaevulinic acid for values less than 0.6 mg.% than with values greater than 0.6 mg.%. All the men concerned in the investigation were employed in dusty occupations. Hypotheses are put forward to attempt to explain the differences in excretion of amino-acetone noted amongst lead workers with high excretion of delta aminolaevulinic acid.Little correlation was found between amino-acetone excretion and that of either porphobilinogen or coproporphyrin.


METHOD USING ORTHO-TOLIDINE FOR THE QUANTITATIVE DETERMINATION OF HAEMOGLOBIN IN SERUM AND URINE. Following a study of the spectrophotometric properties of ortho-tolidine and its oxidation products, with particular attention to variation brought about by change in the hydrogen ion concentration, a method for the quantitative estimation of haemoglobin in serum and urine in which ortho-tolidine is substituted for benzidine in a peroxidase system is described. The method is designed to measure haemoglobin value within the range 0-125 mg. per 100 ml. Evidence is presented showing that it gives results equal in accuracy and reproducibility to a benzidine method in common use and for reasons stated is a more satisfactory technique for estimating the haemoglobin content of urine.


AUTOMATED ESTIMATION OF SODIUM, POTASSIUM, AND CALCIUM USING THE EPPENDORF FLAME PHOTOMETER. An Eppendorf flame photometer may be used to estimate sodium, potassium, and calcium in plasma which has been automatically sampled and diluted. Readings may be automatically recorded by feeding the output from the photomultiplier into a sensitive recorder. This method estimates 60 samples an hour, using approximately 0.12 ml. plasma per estimation. The accuracy of the method is discussed.


RAPID METHOD FOR COUNTING RETICULOCYTES.


HISTOCHEMICAL DEMONSTRATION OF GAMMA GLUTAMYL TRANSPEPTIDASE ACTIVITY IN BONE MARROW AND BLOOD CELLS. The demonstration by a histochemical method of gamma glutamyl transpeptidase is described. In marrow and peripheral blood it has been found useful in differentiating between normal and leukaemic myeloblasts and between marrow (short-lived) lymphocytes and lymph node (long-lived) lymphocytes. The method may also be of value in differentiating between normal and neoplastic cells.


SIMPLE METHOD FOR SEPARATING PLATELETS FROM RED CELLS BEFORE ENUMERATION WITH AN ELECTRONIC COUNTER.


ESTIMATION OF TRUE GLUCOSE IN BLOOD BY THE AUTOANALYSER.


USE OF AN IMMERSIBLE SCINTILLATION COUNTER  IN THE URINARY VITAMIN B 12 EXCRETION TEST.


A SIMPLE CONSTANT-INFUSION APPARATUS FOR VERY SMALL QUANTITIES OF FLUID DELIVERED OVER LONG PERIODS.


METHOD OF SILVER IMPREGNATION FOR NERVOUS TISSUE EMBEDDED IN PARAFFIN.


PREPARATION OF SECTIONS FROM BONE MARROW ASPIRATES AND CELLULAR EXUDATES USING SOLUBLE PLASTIC CENTRIFUGE TUBES.


METHOD FOR THE DETECTION AND MEASUREMENT OF ANTIBODIES TO STREPTOKINASE IN CEREBROSPINAL FLUID.


A MODEL OF HUMAN KARYOTYPE FOR TEACHING.


RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII.


AN ELECTRONIC QUADRAT FOR GENETICS.

AN ELECTRONIC QUADRAT FOR GENETICS.


A FAMILY WITH POLYSYNDACTYLY AND OTHER ANOMALIES.


NUTRITION EDUCATION INVOLVES TOTAL SCHOOL.


AN ECOLOGIC VIEW OF HEALTH AND HEALTH EDUCATION.


GROWTH AND DEVELOPMENT OF IRRADIATED RATS: EFFECTS OF MATERNAL AND PRENATAL GAMMA-IRRADIATION.


MEDICAL NOTES.

MEDICAL NOTES.


REPORT (1964) OF THE STUDY COMMITTEE ON PROFESSIONAL PREPARATION.


MOOD AND EMOTIONS CHARTING.

MOOD AND EMOTIONS CHARTING.


THE TEACHER AND THE REHABILITATION OF THE EMOTIONALLY DISTURBED CHILD.


ADRENAL CYST: REPORT OF TWO CASES.

ADRENAL CYST: REPORT OF TWO CASES.


UNILATERAL MASSIVE ADRENAL HEMORRHAGE IN NEWBORN INFANT.


A ROENTGENOGRAPHIC STUDY OF INTESTINAL ASCARIASIS WITH A REPORT OF 3 CASES OF INTESTINAL OBSTRUCTION CAUSED BY ASCARIS WORMS.


IDIOPATHIC UNILATERAL RENAL HEMATURIA ASSOCIATED WITH ATYPICAL ACID-FAST BACILLUS: BATTEY TYPE. CURE BY PARTIAL NEPHRECTOMY.


GIANT CELL CARCINOMA OF THE LUNG. THE SUPERFICIAL LAYER OF A DOUBLE DECK EPITHELIUM AS A SOURCE OF ORIGIN.


NEPHROPATHY SECONDARY TO ESSENTIAL FAMILIAL HYPERLIPEMIA.


CARCINOMA WITHIN SOLITARY RENAL CYSTS.

CARCINOMA WITHIN SOLITARY RENAL CYSTS.


WILMS TUMOR IN A HORSESHOE KIDNEY.

WILMS TUMOR IN A HORSESHOE KIDNEY.


EMBRYOMA OF KIDNEY IN NEWBORN INFANT: CASE REPORT.


UPPER URETERAL AVULSION SECONDARY TO NON-PENETRATING INJURY.


RECONSTRUCTION OF THE URETER BY FREE AUTOLOGOUS BLADDER MUCOSA GRAFT. I. A PRELIMINARY REPORT.


CLINICO-PATHOLOGICAL CONFERENCE.

CLINICO-PATHOLOGICAL CONFERENCE.


URINARY TRACT RECONSTRUCTION AFTER MODIFIED ANTERIOR EXENTERATION FOR CARCINOMA OF THE CERVIX.


CYSTOURETHROGRAPHY IN PARAPLEGIA AS A GUIDE TO CATHETER-FREE LIFE: 17 YEARS' EXPERIENCE OF A PARAPLEGIC CENTER.


THE NEUROGENIC BLADDER IN CHILDREN WITH CONGENITAL MALFORMATIONS OF THE SPINE: A STUDY OF 61 PATIENTS.


VAS CRUSH FOR PREVENTION OF POST-PROSTATECTOMY EPIDIDYMITIS: AN EXPERIMENTAL AND CLINICAL STUDY.


LEIOMYOSARCOMA OF SCROTUM: CASE REPORT.

LEIOMYOSARCOMA OF SCROTUM: CASE REPORT.


EMBRYONAL CARCINOMA OF THE TESTICLE IN A 9-MONTH-OLD INFANT.


SOME USES OF LYMPHANGIOGRAPHY IN THE MANAGEMENT OF TESTICULAR TUMORS.


RADIOAUTOGRAPHIC DETECTION OF CARCINOMA OF THE PROSTATE.


HOW TO MAKE DIFFERENTIAL FUNCTION STUDIES FOR RENOVASCULAR HYPERTENSION EASIER.


THE USE OF I-125 ORTHO-IODOHIPPURATE FOR LOCALIZING THE RADIOISOTOPE RENOGRAM PROBE.


THE INFLOXRAY MANSCREEN.

THE INFLOXRAY MANSCREEN.


THE USE OF MICROPOROUS TAPE IN THE CUTANEOUS CLOSURE OF SURGICAL WOUNDS.


UROLOGICAL ENDOPHOTOGRAPHY AND ENDOCINEMATOGRAPHY.


OXYGEN-INDUCED RESORPTION OF CARTILAGE IN ORGAN CULTURE.


ROLE OF LYSOSOMES IN OXYGEN TOXICITY.

ROLE OF LYSOSOMES IN OXYGEN TOXICITY.


DELINEATION OF THE THYMIC AND BURSAL LYMPHOID SYSTEMS IN THE CHICKEN.


MOLECULAR MECHANISM OF FORMATION OF AN ANTIGEN-ANTIBODY COMPLEX.


PORTAL BLOOD SUPPLY TO GLOMUS TISSUE AND ITS SIGNIFICANCE.


AUTORADIOGRAPHIC INVESTIGATIONS OF RNA AND DNA METABOLISM OF HUMAN LEUCOCYTES CULTURED WITH PHYTOHAEMAGGLUTININ; URIDINE-5-3H AS A SPECIFIC PRECURSOR OF RNA.


NUCLEAR-CYTOPLASMIC INTERACTIONS.

NUCLEAR-CYTOPLASMIC INTERACTIONS.


A NEW NEUROHYPOPHYSEAL PRINCIPLE IN AN ELASMOBRANCH, RAIA OCELLATA.


ESTERASES IN SPIDER MITES HYDROLYSING ALPHA-NAPHTHYLACETATE.


EFFECTS OF ANTIBIOTICS ON CHROMOSOMES OF CULTURED HUMAN LEUCOCYTES.


CHROMATOGRAPHY OF SOLUBLE MACROMOLECULAR COMPONENTS OF HELA CELLS.


IDENTITY OF COW BETA-LACTOGLOBULIN 'B' AND BUFFALO BETA-LACTOGLOBULIN.


INHIBITION OF PLASMA MONOAMINE OXIDASE BY CYSTEAMINE.


CIRCULATORY AND METABOLIC PROCESSES IN ADIPOSE TISSUE IN VIVO.


CONVERSION OF CYANO- AND HYDROXO-COBALAMIN IN VIVO INTO CO-ENZYME FORM OF VITAMIN B12 IN THE RAT.


FREE AND BOUND NORADRENALINE IN THE RABBIT HEART.


CHEMICAL CONTROL OF SENSORY GANGLIA DURING A CRITICAL PERIOD OF DEVELOPMENT.


A GENERAL THEORY OF THE GENESIS OF DRUG DEPENDENCE BY INDUCTION OF RECEPTORS.


EFFECT OF SEGONTIN AND RESERPINE ON ISOLATED MEDULLARY GRANULES.


METABOLISM OF ACID MUCOPOLYSACCHARIDES OF THE RABBIT'S DERMIS FOLLOWING SKIN TREATMENT WITH IRRITATING SUBSTANCES.


ACID DEOXYRIBONUCLEASE ACTIVITY IN PERIPHERAL LEUCOCYTES OF SWISS MICE.


HAEMOGLOBIN N OF SHEEP.

HAEMOGLOBIN N OF SHEEP.


HAEMOGLOBIN O ARAB IN BULGARIA.

HAEMOGLOBIN O ARAB IN BULGARIA.


RECOVERY OF MYCOPLASMAS IN THE STUDY OF HUMAN LEUKAEMIA AND OTHER MALIGNANCIES.


A RAPID TECHNIQUE FOR DETECTING MULTIPLE ANTIGEN-ANTIBODY PRECIPITIN REACTIONS.


ESTERASE STUDIES ON DOG MAST-CELL TUMOURS.


A RADIOIMMUNOASSAY FOR HUMAN CHORIONIC GONADOTROPHIN.


EFFECT OF PURINOYL HUMAN SERUM ALBUMIN ON TRANSPLANTED EHRLICH ASCITES TUMOUR IN MICE.


RETICULO-ENDOTHELIAL FUNCTION IN THYMECTOMIZED RATS.


IMMUNE RESPONSE INDUCED BY RNA-IMMUNO-CARRIER EXTRACTED FROM HETEROLOGOUS IMMUNE SERA.


EFFECT OF DENERVATION ON THE LACTATE DEHYDROGENASE ISOZYMES OF SKELETAL MUSCLE.


RETENTION OF SR-90 IN LACTATING RATS.

RETENTION OF SR-90 IN LACTATING RATS.


ABSORPTION AND RETENTION OF INGESTED STRONTIUM AND CALCIUM IN BEAGLES AS A FUNCTION OF AGE.


LOCOMOTION IN THE AUSTRALIAN MARSUPIAL ANTECHINOMYS.


MECHANISM OF ANAPHYLACTIC DEATH IN THE MOUSE.


ISOLATION OF A PARASYMPATHOMIMETIC ALKALOID OF FUNGAL ORIGIN.


GLUTARIC ACID DIALDEHYDE; A ROUTINE FIXATIVE FOR CENTRAL NERVOUS SYSTEM ELECTRON MICROSCOPY.


SERUM ALBUMIN AND TRANSFERRIN POLYMORPHISM IN EAST AFRICAN CATTLE.


BEHAVIOR OF AN ATTENUATED STRAIN OF FOOT-AND-MOUTH DISEASE VIRUS IN CULTURE.


ELECTRON MICROSCOPY OF A TICK-BORNE ENCEPHALITIS VIRUS.


HIGHLIGHTS OF STATE HEALTH COMMISSIONER'S REPORT FOR 1964 AND PROSPECTS FOR 1965.


MEDICAL CARE IN A DISASTER; A LONG-TERM PROBLEM.


DIETARY FATS AND BLOOD CHOLESTEROL LEVELS IN ELDERLY PERSONS; A TEN-YEAR STUDY.


PRIMARY KIDNEY DISEASE IN PATIENTS WITH CIRRHOSIS OF THE LIVER.


ANTIBIOTIC SUSCEPTIBILITY OF PATHOGENIC MICROORGANISMS ISOLATED IN 1963.


PULMONARY FAILURE IN A SIXTY-SIX-YEAR-OLD MAN.


ARTERIOVENOUS MALFORMATION OF THE BRAIN.


MISDIAGNOSIS OF BRONCHOSPASM DURING ANESTHESIA.


AN INBORN ERROR OF METABOLISM ASSOCIATED WITH DEFICIENCY OF ENZYME CYSTATHIONINE SYNTHETASE LEADING TO HOMOCYSTINURIA.


NEUROLOGIC COMPLICATIONS OF INFECTIOUS MONONUCLEOSIS.


INFERTILITY, SALPINGITIS, AND UTERINE ANOMALY.


SEGMENTAL COLITIS WITHOUT ROENTGENOGRAPHIC CHANGES.


SURGICAL EXCISION OF TUBERCULOUS STRICTURE OF LOWER END OF URETER WITH NEOCYSTOSTOMY.


JOHN BYRNE, M.D., M.R.C.S.E., LL.D. FIRST PRESIDENT OF THE BROOKLYN GYNECOLOGICAL SOCIETY.


PELVIC EXTRAGENITAL TUMORS IN WOMEN. A STUDY OF 200 PATIENTS AND A REVIEW OF THE LITERATURE.


THE ACUTE ABDOMEN IN THE PUERPERIUM. THREE CASE REPORTS AND REVIEW OF LITERATURE.


RECOVERY FROM SUBLETHAL X-RAY DAMAGE IN SURVIVING YEAST CELLS.


NEUTRON-INDUCED DENTAL FRAGILITY.

NEUTRON-INDUCED DENTAL FRAGILITY.


THE DEPENDENCE OF RBE ON THE ENERGY OF FAST NEUTRONS. IV. INDUCTION OF LENS OPACITIES IN MICE.


ELECTRON SPIN RESONANCE OF X-IRRADIATED TARTRONIC ACID.


GAMMA-RAY-INDUCED PERMEABILITY CHANGES IN RELATION TO EARLY MORTALITY IN THE CHICK.


THE INTESTINAL MUCOSA OF GERMFREE MICE AFTER WHOLE-BODY X-IRRADIATION WITH 3 KILOROENTGENS.


INCORPORATION OF H3-PHENYLALANINE INTO SERUM PROTEINS BY THE PERFUSED LIVER OF NORMAL AND X-IRRADIATED RATS.


PROTECTION AGAINST ACUTE RADIATION ULCERATION IN HEALING RAT EPIDERMIS.


STUDIES OF THE MORTALITY OF A-BOMB SURVIVORS. 3. DESCRIPTION OF THE SAMPLE AND MORTALITY, 1950--1960.


RENAL FUNCTIONS IN ACUTE RADIATION SICKNESS.


REPOPULATION OF BONE MARROW IN MICE: NUMBER AND TYPE OF CELLS REQUIRED FOR POST-X-IRRADIATION PROTECTION.


THE GENETIC CONTROL OF RADIOSENSITIVITY IN PSEUDOMONAS AERUGINOSA.


ABSCOPAL EFFECTS OF WHOLE-BODY X-IRRADIATION ON COMPENSATORY HYPERTROPHY OF THE RAT KIDNEY.


MODIFICATION OF POSTIRRADIATION TAURINE EXCRETION BY CYSTEINE ADMINISTRATION.


POSTIRRADIATION GROWTH, DIVISION, AND RECOVERY IN BACTERIA.


BUOYANCY AS PREDICTED BY CERTAIN ANTHROPOMETRIC MEASUREMENTS.


DETERMINATION OF THE OPTIMUM SETTING OF AN ADJUSTABLE GRIP DYNAMOMETER.


TIME AND MOTION ANALYSIS OF COMPETITIVE FREESTYLE SWIMMING TURNS.


CHRISTOPHER P. LINHART, M.D., FORGOTTEN PHYSICAL EDUCATOR.


EFFECT OF PASSIVE WARM-UP ON MUSCULAR STRENGTH AND ENDURANCE.


THOMPSON SMOKING AND TOBACCO KNOWLEDGE TEST.


THE FACTOR STRUCTURE OF MAJOR LEAGUE BASEBALL RECORDS.


IMPROVEMENTS RESULTING FROM A FITNESS PROGRAM.


COMPARISON OF THE DRY BODY AND WET BODY STARTS IN SWIMMING.


RELATIONSHIP OF SELECTED ANTHROPOMETRIC AND PHYSICAL PERFORMANCE MEASURES TO PERFORMANCE IN THE RUNNING HOP, STEP, AND JUMP.


EFFECT OF STRENGTH DEVELOPMENT ON SPEED OF SHOOTING OF VARSITY ICE HOCKEY PLAYERS.


FIGURAL AFTEREFFECTS RESULTING FROM GROSS ACTION PATTERNS.


AN ANALYTICAL METHOD OF RATING SYNCHRONIZED SWIMMING STUNTS.


EFFECT OF ADDED CALISTHENICS ON THE PHYSICAL FITNESS OF FOURTH GRADE BOYS AND GIRLS.


RELATIONSHIP OF THE GRAVITY LINE TEST TO POSTURE, TRUNK STRENGTH, AND HIP-TRUNK FLEXIBILITY OF ELEMENTARY SCHOOL GIRLS.


EFFECT OF BLOOD LOSS UPON PERFORMANCE IN THE BALKE-WARE TREADMILL TEST.


BASEBALL: ELECTROMYOGRAPHIC STUDY OF BATTING SWING.


LEG ANGLE AND MUSCULAR EFFICIENCY IN THE INVERTED LEG PRESS.


CARDIOVASCULAR EFFICIENCY TEST SCORES FOR JUNIOR AND SENIOR HIGH SCHOOL GIRLS IN THE UNITED STATES.


RELATIONSHIP BETWEEN THE RELATIVE AND ABSOLUTE ISOMETRIC ENDURANCE OF AN ISOLATED MUSCLE GROUP.


CIRCULATORY ADJUSTMENTS TO TRAINING FOR APNEIC DIVING.


RE-EVALUATION OF ISOMETRIC TRAINING METHODS AND RESULTS, A MUST.


RELIABILITY STUDY OF CABLE TENSION STRENGTH TESTING AS COMPARED TO MANUOMETER PUSH APPARATUS.


EFFECT OF EATING AT VARIOUS TIMES UPON SUBSEQUENT PERFORMANCES IN THE ONE-MILE RUN.


EFFECTS OF ISOMETRIC TRAINING ON VERTICAL JUMPING.


THE CALORIC COST OF PLAYING HANDBALL.

THE CALORIC COST OF PLAYING HANDBALL.


PSYCHOMOTOR RESPONSES AND THEIR RELATIONSHIP TO PERSONALITY TRAITS OF YOUNG MEN PERFORMING IN HIGH AMBIENT TEMPERATURE (110 F).


EFFECTS OF ISOMETRIC AND DYNAMIC WEIGHT-TRAINING EXERCISES UPON STRENGTH AND SPEED OF MOVEMENT.


RELATIONSHIPS BETWEEN STANDING BROAD JUMP AND VARIOUS MATURATIONAL, ANTHROPOMETRIC, AND STRENGTH TESTS OF 12-YEAR-OLD BOYS.


EFFECT OF PRIMARY AND SECONDARY GROUP INTERACTION UPON IMPROVEMENT IN A COMPLEX MOVEMENT TASK.


RELATIONSHIP BETWEEN OBESITY AND TREADMILL PERFORMANCE IN SEDENTARY AND ACTIVE YOUNG MEN.


AN INSTRUMENT FOR EVALUATING COLLEGE AND UNIVERSITY HEALTH SERVICE PROGRAMS.


EFFECT OF KNOWLEDGE OF RESULTS ON ISOMETRIC STRENGTH SCORES.


KINAESTHESIS AND MENTAL PRACTICE.

KINAESTHESIS AND MENTAL PRACTICE.


NASAL CARRIERS OF PATHOGENIC STAPHYLOCCI.


PROGRESSIVE TREADMILL TEST NORMS FOR COLLEGE MALES.


BOWLING NORMS FOR COLLEGE STUDENTS IN ELECTIVE PHYSICAL EDUCATION CLASSES.


THE RELIABILITY OF THE YOUTH FITNESS TEST.


ELECTROGONIOMETRIC STUDY OF LOCOMOTION AND OF SOME ATHLETIC MOVEMENTS.


ELECTROGONIOMETRIC STUDY OF WALKING ON HIGH HEELS.


ELECTROGONIOMETRIC ANALYSIS OF NORMAL AND PATHOLOGICAL GAITS.


EFFECT OF HEIGHT OF THE HEEL UPON THE FOOT.


STUDY OF ENDURANCE OF VARIOUS MUSCLE GROUPS.


ERGOGENIC EFFECT OF GLYCINE AND NIACIN SEPARATELY AND IN COMBINATION.


EFFECT OF WALKING IN COWBOY BOOTS ON THE KNEE ACTION.


PHYSICAL FITNESS OF SENIOR HIGH SCHOOL BOYS AND GIRLS PARTICIPATING IN SELECTED PHYSICAL EDUCATION PROGRAMS IN NEW YORK STATE.


MORPHOLOGICAL BISEXUALITY AS A FACTOR IN THE MOTOR PERFORMANCE OF COLLEGE WOMEN.


RELATIONSHIP OF REACTION TIME TO THE SPEED OF A SOFTBALL.


BODY STRUCTURE AND DESIGN: FACTORS IN THE MOTOR PERFORMANCE OF COLLEGE WOMEN.


A COMPARISON OF FOUR GRIPS USED IN THROWING THE JAVELIN.


RELATIONSHIP BETWEEN PHYSICAL FITNESS AND ACADEMIC SUCCESS.


EFFECT OF ALTITUDE ON ATHLETIC PERFORMANCE.


A CINEMATOGRAPHICAL ANALYSIS OF SPRINT RUNNING.


EFFECTS OF VARIOUS TRAINING PROGRAMS ON RUNNING SPEED.


THROWING AND KICKING ABILITY OF 8-YEAR-OLD BOYS AND GIRLS.


EFFECTS OF AN EMPHASIS ON CONCEPTUALIZING TECHNIQUES DURING EARLY LEARNING OF A GROSS MOTOR SKILL.


A METHOD TO MEASURE MUSCLE FIRMNESS OR TONE.


CERTAIN HARMFUL HEALTH MISCONCEPTIONS OF JUNIOR HIGH STUDENTS ATTENDING PUBLIC SCHOOLS IN METROPOLITAN AREAS.


EXPRESSED ATTITUDES OF VARIOUS GROUPS OF ATHLETES TOWARD ATHLETIC COMPETITION.


EFFECTS OF VARIATION OF FOREARM POSITION IN ELBOW FLEXION.


TIMING OF TWO SIMULTANEOUS MOVEMENTS OF ARMS AND LEGS.


PHYSICAL MATURITY, MUSCULAR STRENGTH, AND MOTOR PERFORMANCE OF YOUNG SCHOOL-AGE BOYS.


EFFECT OF ACTIVELY INCREASED MUSCLE TEMPERATURE ON LOCAL MUSCULAR ENDURANCE.


PERSONALITY AND INTELLIGENCE CHARACTERISTICS OF SELECTED HIGH SCHOOL ATHLETES AND NONATHLETES.


EFFECT OF MUSCULAR STRETCH, TENSION, AND RELAXATION UPON THE REACTION TIME AND SPEED OF MOVEMENT OF A SUPPORTED LIMB.


INFLUENCE OF STRENGTH TRAINING ON PRE-TENSED AND FREE-ARM SPEED.


RELATIONSHIP BETWEEN STRENGTH AND ATTITUDES TOWARD PHYSICAL EDUCATION ACTIVITY AMONG COLLEGE WOMEN.


THE RAT AS A RESEARCH TOOL IN PHYSICAL EDUCATION.


VENTRICULO-ATRIAL SHUNT IN THE MANAGEMENT OF HYDROCEPHALUS.


PROBLEMS OF SKIN COVERAGE OF THE HAND.

PROBLEMS OF SKIN COVERAGE OF THE HAND.


STRAW ITCH MITE DERMATITIS CAUSED BY PYEMOTES VENTRICOSUS: COMPARATIVE ASPECTS.


CLINICAL ASPECTS OF LEPROSY.

CLINICAL ASPECTS OF LEPROSY.


THE REHABILITATION OF THE FRACTURED HIP IN THE AGED.


REHABILITATION CENTERS AND THEIR AID TO THE GENERAL PRACTITIONER AND PHYSICIANS IN INDUSTRIAL MEDICINE.


A NEW METHOD OF IONTOPHORESIS AND ANALYSIS OF SWEAT ELECTROLYTE: A SURVEY OF SEVERAL KINDRED WITH CYSTIC FIBROSIS.


MANAGEMENT OF EXSTROPHY OF THE BLADDER.

MANAGEMENT OF EXSTROPHY OF THE BLADDER.


PERIANAL LIPOFASCIAL HERNIAS.

PERIANAL LIPOFASCIAL HERNIAS.


A NEW NEEDLE FOR CAROTID ANGIOGRAPHY.

A NEW NEEDLE FOR CAROTID ANGIOGRAPHY.


ACUTE MASTOIDITIS RESISTANT TO MEDICAL MANAGEMENT.


EXTERNAL CARDIAC MASSAGE: A CAUSE OF BONE MARROW AND FAT EMBOLI.


CONSERVATIVE MANAGEMENT OF THE LOW BACK SYNDROME--A SUMMARIZATION.


MANAGEMENT OF POLYPS OF THE LARGE BOWEL.


THE TREATMENT OF UTERINE AND VAGINAL PROLAPSE IN THE ELDERLY WOMAN.


RADICAL RETROPUBIC PROSTATECTOMY FOR CARCINOMA OF PROSTATE.


THE APPLICATION OF SIMPLE PHOTOGRAPHIC METHODS IN DISORDERS OF MOTION.


SPECIFIC OCULAR UVEAL LESIONS IN PATIENTS WITH EVIDENCE OF HISTOPLASMOSIS AND TOXOPLASMOSIS.


THE EVALUATION OF PATIENTS WITH CHRONIC OCCLUSIVE PERIPHERAL VASCULAR DISEASE.


NEW HORIZONS IN THE PRIVATE PRACTICE OF MEDICINE.


PHYSICAL FITNESS AND BRONCHIAL ASTHMA.

PHYSICAL FITNESS AND BRONCHIAL ASTHMA.


USE OF DRUGS IN INFANTS AND CHILDREN: UNIQUE FEATURES AS COMPARED TO ADULT USE.


ROLE OF ENDOSCOPY IN DIAGNOSIS OF BLADDER NECK OBSTRUCTION: "ONE LOOK MEANS A LOT".


THE SIGNIFICANCE OF INTERMITTENT CLAUDICATION.


BILE PERITONITIS AND ACUTE RENAL FAILURE TREATED BY PERITONEAL DIALYSIS.


THE LEVATOR SYNDROME AND ITS TREATMENT.

THE LEVATOR SYNDROME AND ITS TREATMENT.


USE AND ABUSE OF OXYTOCICS.

USE AND ABUSE OF OXYTOCICS.


MEDICAL GRAND ROUNDS FROM THE UNIVERSITY OF ALABAMA MEDICAL CENTER.


COMMON QUESTIONS ABOUT ALLERGY AND OUR ANSWERS.


CONGENITAL INDIFFERENCE TO PAIN WITH ASSOCIATED ORTHOPEDIC ABNORMALITIES.


REGULATORY CHAOS.

REGULATORY CHAOS.


THE PHYSIOLOGY OF MUSCLE SPASM AS RELATED TO LOW BACK PAIN.


THE ETIOLOGY OF SUDDEN, UNEXPECTED DEATH.


RECOVERY EFFECTS OF HOMOLOGOUS LIVER DEOXYRIBONUCLEIC ACID INJECTED INTO TOTAL-BODY IRRADIATED (600 R) INFANTILE RATS.


STATISTICAL CONSIDERATIONS FOR CLINICAL STUDIES OF DENTAL CARIES. TECHN DOCUM REP NO. SAM-TDR-64-27.


PAROTID FLUID CORTICOSTEROID LEVELS AT ONE AND TWO HOURS AFTER GRADED DOSES OF ACTH. TECHN DOCUM REP NO. SAM-TDR-64-50.


IN VITRO EFFECTIVENESS OF TOPICAL APPLICATIONS OF LOW CONCENTRATION STANNOUS FLUORIDE SOLUTIONS. TECHN DOCUM REP NO. SAM-TDR-64-20.


STANNOUS FLUORIDE TOPICALLY APPLIED IN AQUEOUS SOLUTION IN CARIES PREVENTION IN A MILITARY POPULATION. TECHN DOCUM REP NO. SAM-TDR-64-26.


A STUDY OF DIGITAL COMPUTERS FOR A REAL TIME TRAINING SIMULATION RESEARCH SYSTEM. TECHN DOCUM REP NO. AMRL-TDR-64-22.


FINGER DEXTERITY OF THE PRESSURE-SUITED SUBJECT. TECHN DOCUM REP NO. AMRL-TDR-64-41.


MOTION SICKNESS SYMPTOMATOLOGY OF LABYRINTHINE DEFECTIVE AND NORMAL SUBJECTS DURING ZERO GRAVITY MANEUVERS. TECHN DOCUM REP NO. AMRL-TDR-64-47.


PATHOLOGY AND TOXICOLOGY OF REPEATED DOSES OF HYDRAZINE AND 1,1-DIMETHYLHYDRAZINE IN MONKEYS AND RATS. TTECHN DOCUM REP NO. AMRL-TDR-64-43.


TIME HISTORY AS AN INFORMATION SOURCE FOR OPERATOR CONTROL OF ORBITAL RENDEZVOUS. TECHN DOCUM REP NO. AMRL-TDR-64-55.


HEIGHT-WEIGHT SIZING OF PROTECTIVE GARMENTS, BASED ON JAPANESE AIR SELF-DEFENSE FORCE PILOT DATA, WITH FIT-TEST RESULTS. TECHN DOCUM REP NO. AMRL-TDR-64-66.


PREDICTING THE DIFFICULTY OF LOCATING TARGETS FROM JUDGMENTS OF IMAGE CHARACTERISTICS. TECHN DOCUM REP NO. AMRL-TDR-64-19.


DEVELOPMENT OF FOOD ITEMS TO MEET AIR FORCE REQUIREMENTS FOR SPACE TRAVEL. TECHN DOCUM REP NO. AMRL-TDR-64-38.


COMBINED EFFECTS OF SLEEP LOSS AND DEMANDING WORK-REST SCHEDULES ON CREW PERFORMANCE. TECHN DOCUM REP NO. AMRL-TDR-64-63.


SPECIFICATION OF OPTIMUM FAULT ISOLATION PRESENTATION. TECHN DOCUM REP NO. AMRL-TDR-64-57.


DONNING AND DOFFING THE "PHASE B" APOLLO PROTOTYPE SPACE SUIT DURING ZERO GRAVITY . TECHN DOCUM REP NO. AMRL-TDR-64-32.


RESEARCH ON THE CYTOCHEMISTRY OF CELL WALLS OF MICROORGANISMS. TECHN DOCUM REP NO. AMRL-TDR-64-52.


THE USE OF AUDITORY FEEDBACK IN SIMPLE REMOTE-HANDLING TASKS. TECHN DOCUM REP NO. AMRL-TDR-64-46.


THE EFFERENT VESTIBULAR SYSTEM. ELECTROPHYSIOLOGICAL RESEARCH.


SMALLPOX VACCINATION STUDIES WITH SERIAL DILUTIONS OF VACCINE. 2. STATISTICAL EVALUATION OF QUANTAL RESPONSE DATA.


THE PRODUCTION OF ANTI-LP(A)-SERA IN RABBITS.


IMMUNOCHEMICAL STUDIES OF ANTI-LP(A)-SERA.


HYPO-7S-GAMMA-GLOBULINAEMIA IN MATURE CATTLE.


EFFECT OF IMMUNIZATION WITH HOMOLOGOUS RETROBULBAR TISSUE EXTRACTS ON THE DEVELOPMENT OF EXPERIMENTAL ENDOCRINE EXOPHTHALMOS.


PRIMARY MENINGEAL MELANOSIS. A CLINICO-PATHOLOGICAL REPORT OF TWO CASES.


SOME EFFECTS OF CATIONIC POLYMERS ON CELL ATTACHMENT AND GROWTH BEHAVIOR: STUDIES WITH POLYBRENE.


MILIA FORMATION IN ORAL LESIONS IN EPIDERMOLYSIS BULLOSA.


STUDIES ON TRANSFORMATION IN MORAXELLA AND ORGANISMS ASSUMED TO BE RELATED TO MORAXELLA. 3. QUANTITATIVE STREPTOMYCIN RESISTANCE TRANSFORMATION BETWEEN MORAXELLA BOVIS AND MORAXELLA NONLIQUEFACIENS STRAINS.


THE INFLUENCE OF INTERFERON AND HYDROCORTISONE ON THE PRODUCTION OF INCOMPLETE INFLUENZA VIRUS IN OVO.


STUDIES ON THE ANTIGENIC STRUCTURE OF THE 80/81 COMPLEX OF STAPHYLOCOCCUS AUREUS. 3. PURIFICATION AND CHEMICAL CHARACTERIZATION OF A MAJOR POLYSACCHARIDE PRECIPITINOGEN.


VIRAL SUSCEPTIBILITY AND EMBRYONIC DIFFERENTIATION. 5. LOCALIZATION OF VIRUS-LIKE PARTICLES IN MOUSE KIDNEY RUDIMENT INFECTED WITH POLYOMA VIRUS.


THE PASSAGE OF PENICILLIN INTO THE CEREBROSPINAL FLUID AFTER INTRACISTERNAL INJECTION OF DEAD BACTERIA OR BACTERIAL TOXINS: AN EXPERIMENTAL INVESTIGATION IN RABBITS.


SMALLPOX VACCINATION STUDIES WITH SERIAL DILUTIONS OF VACCINE. 1. PRIMARY VACCINATION AND REVACCINATION IN HUMAN ADULTS.


POLYOMA VIRUS. 2. FURTHER STUDIES ON THE INTERACTION OF POLYOMA VIRUS WITH MOUSE EMBRYO CELLS AT LOW TEMPERATURE.


PROTOTROPIC TAUTOMERISM OF HETEROAROMATIC COMPOUNDS. 3. FIVE-MEMBERED RINGS AND ONE HETERO ATOM.


THE REACTIONS OF DIAZOMETHANE WITH HETEROCYCLIC COMPOUNDS.


THE PRESENT STATE OF SELENAZOLE CHEMISTRY.


REPORT ON THE COMMUNITY MENTAL HEALTH CENTERS PROGRAM.


THE YOUNG DROP-OUT IN THE MENTAL HOSPITAL.


DIAGNOSTIC TEST BATTERY FOR OCCUPATIONAL THERAPY.


A PREDICTION OF CLINICAL PERFORMANCE.

A PREDICTION OF CLINICAL PERFORMANCE.


PSYCHIATRIC OCCUPATIONAL THERAPY.

PSYCHIATRIC OCCUPATIONAL THERAPY.


WILSON'S DISEASE.

WILSON'S DISEASE.


A FACTOR ANALYTCALLY DERIVED SCALE FOR RATING PSYCHIATRIC PATIENTS IN OCCUPATIONAL THERAPY. II. CONCURRENT VALIDITY.


ADJUSTABLE TABLE WITH CHANGEABLE INSERTS.


THE SHWARTZMAN REACTION: PATHOGENETIC MECHANISMS AND CLINICAL MANIFESTATIONS.


POLYCYTHEMIA VERA AND SOME POSSIBLE PATHOGENETIC MECHANISMS.


RELATION OF ABNORMAL PROTEINS TO FORMED ELEMENTS OF BLOOD: CELLULAR SOURCES.


CARDIAC METABOLISM.

CARDIAC METABOLISM.


A PROBLEM SOLVING METHOD OF LEARNING MEASURED AGAINST A ROTE MEMORY METHOD.


UTILIZATION OF OCCUPATIONAL THERAPY IN AEROSPACE RESEARCH.


TREATMENT OF FLEXION CONTRACTURES IN OCCUPATIONAL THERAPY.


BACTERIAL ENDOTOXEMIA.

BACTERIAL ENDOTOXEMIA.


DISEASES OF THE PERICARDIUM.

DISEASES OF THE PERICARDIUM.


KIDNEY DISEASE IN PREGNANCY.

KIDNEY DISEASE IN PREGNANCY.


COMPUTERS IN MEDICINE.

COMPUTERS IN MEDICINE.


HYPERBARIC MEDICINE.

HYPERBARIC MEDICINE.


SOME THERAPEUTIC APPROACHES TO CHRONIC RENAL INSUFFICIENCY.


SURGICAL TREATMENT OF PARKINSONISM.

SURGICAL TREATMENT OF PARKINSONISM.


THE AORTIC VALVE.

THE AORTIC VALVE.


DEFECTS OF INTESTINAL DISACCHARIDE ABSORPTION.


FOLIC ACID.

FOLIC ACID.


DIGITALIS.

DIGITALIS.


DIFFERENCES IN THE FREQUENCY OF DISEASE IN DIFFERENT POPULATIONS.


SEQUELAE OF LOW BIRTH WEIGHT.

SEQUELAE OF LOW BIRTH WEIGHT.


HUMAN PITUITARY GROWTH HORMONE.

HUMAN PITUITARY GROWTH HORMONE.


INFLUENCE OF HORMONES ON SEXUAL BEHAVIOR.


HORMONAL EFFECTS OF NONENDOCRINE TUMORS.


THE FINE STRUCTURE OF NORMAL AND DEGENERATING SYNAPSES OF THE CENTRAL NERVOUS SYSTEM.


CELL CONTACTS IN MORPHOGENESIS.

CELL CONTACTS IN MORPHOGENESIS.


STRUCTURAL ASPECTS OF ENDOCRINE SECRETION.


ENDOCRINE INFLUENCE ON CEREBRAL DEVELOPMENT.


SOME ASPECTS OF THE CYTOLOGY OF WOUND HEALING.


SEROTONIN AND LOCAL EFFECT OF X-RAYS. 7. THE PROTECTIVE EFFECT OF REPEATED INJECTIONS OF SEROTONIN.


ANGIOKERATOSIS NAEVIFORMIS--A FORM OF NAEVUS TELANGIECTATICUS LATERALIS (NAEVUS FLAMMEUS).


PAINTING TREATMENT OF NITROGEN MUSTARD IN MYCOSIS FUNGOIDES.


A RARE FORM OF AN INHERITABLE PALMAR AND PLANTAR KERATOSIS.


PSORIASIS; A STATISTICAL STUDY OF THE GOECKERMAN AND THE CHRYSAROBIN THERAPIES, AND OF VARIOUS FACTORS INFLUENCING THE CLINIC.


A DESCRIPTIVE STUDY OF THE CYTOLOGY OF THE ADRENAL GLANDS OF SOUTH INDIAN ANURANS.


THE DISTRIBUTION OF I-131-LABELLED PAROTIN INTO THE MUSCLE TISSUE OF NORMAL AND OVARIECTOMIZED GUINEA PIG SENSITIZED WITH PAROTIN.


EFFECTS OF GONADECTOMY AND SEX STEROIDS ON THE ACID PHOSPHATASE ACTIVITY OF THE HYPOTHALAMOHYPOPHYSIAL SYSTEM IN THE BIRD, EMBERIZA RUSTICA LATIFASCIA.


PERSISTENT-ESTROUS AND-DIESTROUS CONDITIONS INDUCED BY EARLY POSTNATAL ADMINISTRATION OF ESTROGEN IN FEMALE RATS.


URINARY 17-HYDROXYCORTICOSTEROIDS, 17-KETOSTEROIDS, PREGNANEDIOL AND PREGNANETRIOL IN PATIENTS WITH MYASTHENIA GRAVIS.


THE EFFECTS OF RESERPINE ON REPRODUCTIVE FUNCTION IN FEMALE RATS.


CURRICULUM AND DISORDERED BEHAVIOR.

CURRICULUM AND DISORDERED BEHAVIOR.


A COMPARISON OF THE COMPETENCIES FOR REGULAR CLASSROOM TEACHERS AND TEACHERS OF EMOTIONALLY DISTURBED CHILDREN.


THE ACADEMIC-ACTIVITY PROGRAM AT HAWTHORNE--A SPECIALLY DESIGNED EDUCATIONAL PROGRAM FOR THE TROUBLED ADOLESCENT.


ACTIVITIES AND ATTITUDES OF PHYSICALLY HANDICAPPED SPECIAL EDUCATION GRADUATES.


THE BOY WHO READ AT EIGHTEEN MONTHS.

THE BOY WHO READ AT EIGHTEEN MONTHS.


THE EFFECTS OF SEX DIFFERENCES ON PROTECTIVE ATTITUDES IN DELINQUENTS AND NONDELINQUENTS.


CRITICAL FACTORS INFLUENCING EDUCATIONAL PROGRAMMING FOR DISTURBED CHILDREN.


A METHOD OF IDENTIFYING CULTURALLY DEPRIVED KINDERGARTEN CHILDREN.


ADMINISTRATION OF SPECIAL EDUCATION: ASPECTS OF A PROFESSIONAL PROBLEM.


SPECIAL EDUCATION--FACTS AND ATTITUDES.

SPECIAL EDUCATION--FACTS AND ATTITUDES.


A CONCEPTUALIZED MODEL FOR COMMUNITY SERVICES FOR THE MENTALLY RETARDED.


SPECIAL EDUCATION MOVES AHEAD: A COMMENT ON THE EDUCATION OF TEACHERS.


CAREER CHOICE FACTORS IN SPECIAL EDUCATION.


THE "BRAIN-INJURED" CHILD IN A CLINIC POPULATION: A STATISTICAL DESCRIPTION.


EDUCATION OF THE GIFTED IN THE USSR.

EDUCATION OF THE GIFTED IN THE USSR.


COUNSELING HEARING HANDICAPPED CHILDREN IN SCHOOL.


CHILDREN'S PERCEPTION OF A SPECIAL CLASS FOR EDUCABLE MENTALLY RETARDED CHILDREN.


PROGRAMMED INSTRUCTION IN WRITTEN LANGUAGE FOR THE DEAF.


TEAM TEACHING WITH TRAINABLE MENTALLY RETARDED CHILDREN.


A COMPARISON OF THE PERFORMANCE OF NORMAL AND SUBNORMAL BOYS ON STRUCTURED CATEGORIZATION TASKS.


A VALENTINE UNIT SUGGESTS A UNIT ON SELF-AWARENESS.


LANGUAGE INSTRUCTION FOR DEAF CHILDREN: AN INTRODUCTION TO SELECTED PAPERS.


CONCEPT DEVELOPMENT AND LANGUAGE INSTRUCTION.


A HISTORICAL OVERVIEW ON LANGUAGE TEACHING.


AN EARLY ATTEMPT IN PROFUSELY ILLUSTRATED LANGUAGE INSTRUCTION.


PRACTICES IN LANGUAGE INSTRUCTION.

PRACTICES IN LANGUAGE INSTRUCTION.


THE IMPACT OF INDIVIDUAL DIFFERENCES ON LANGUAGE LEARNING.


THE APPLICABILITY OF INDIVIDUALIZED PROGRAMED INSTRUCTION IN THE EDUCATION OF DEAF CHILDREN.


SCHOLARSHIPS AND FELLOWSHIPS IN SPECIAL EDUCATION.


THE SWORD AND THE SPIRIT.

THE SWORD AND THE SPIRIT.


CREATIVE THINKING: SOME THOUGHTS ON RESEARCH.


RECENT FEDERAL LEGISLATION--PROVISIONS AND IMPLICATIONS FOR SPECIAL EDUCATION.


EDUCATIONAL DISABILITY IN EMOTIONALLY DISTURBED CHILDREN.


PICTURE DRAMA.

PICTURE DRAMA.


THE JAPANESE ABACUS AS A COMPUTATIONAL AID FOR BLIND CHILDREN.


A SCHOOL FOLLOW-UP STUDY OF CHILDREN DISCHARGED FROM A PSYCHIATRIC HOSPITAL.


STIMULATING SPECIAL EDUCATION THROUGH FEDERAL LEGISLATION.


THE EFFECTS OF TYPING INSTRUCTION ON THE PERSONALITY AND ACHIEVEMENT OF EDUCABLE MENTALLY HANDICAPPED CHILDREN.


INDEPENDENCE-CONFORMITY BEHAVIOR AS A FUNCTION OF INTELLECT: BRIGHT AND DULL CHILDREN.


CULTURALLY DEPRIVED CHILDREN: OPINIONS OF TEACHERS ON THE VIEWS OF RIESSMAN.


DIFFERENTIAL DIAGNOSIS OF AUDITORY DEFICITS--A REVIEW OF THE LITERATURE.


JOB TRAINING PLACEMENT FOR RETARDED YOUTH.


ADMINISTRATIVE PROBLEMS IN SPECIAL EDUCATION.


A MOTIVATIONAL READING PROGRAM FOR DISTURBED CHILDREN.


THE MENTAL RETARDATION PROGRAM OF THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE.


TELETEACHING--A NEW APPROACH TO TEACHING ELEMENTARY AND SECONDARY HOMEBOUND PUPILS.


THE TRAINING OF DIRECTORS AND SUPERVISORS OF SPECIAL EDUCATION PROGRAMS.


AN INVESTIGATION OF THE FAMILY BACKGROUNDS OF EDUCABLE MENTALLY RETARDED CHILDREN IN SPECIAL CLASSES.


LEARNING DISABILITIES: AN INTRODUCTION TO SELECTED PAPERS.


LEARNING DISABILITIES--YESTERDAY, TODAY, AND TOMORROW.


THE NEUROLOGICAL STUDY OF CHILDREN WITH LEARNING DISABILITIES.


DIAGNOSTIC METHODS USED WITH LEARNING DISABILITY CASES.


CHARACTERISTICS OF DYSLEXIA AND THEIR REMEDIAL IMPLICATION.


PERCEPTUAL-MOTOR ASPECTS OF LEARNING DISABILITIES.


A HIERARCHY OF EDUCATIONAL TASKS FOR CHILDREN WITH LEARNING DISORDERS.


CAN DEFICIENCY PRODUCE SPECIFIC SUPERIORITY--THE CHALLENGE OF THE IDIOT SAVANT.


LISTENING COMPREHENSION OF CEREBRAL PALSIED AND OTHER CRIPPLED CHILDREN AS A FUNCTION OF TWO SPEAKING RATES.


VERBAL DEVELOPMENT IN A MONGOLOID.

VERBAL DEVELOPMENT IN A MONGOLOID.


SPEECH DIFFERENCES AMONG CEREBRAL PALSY SUBCLASSES.


VALIDATION OF TESTS OF CREATIVE THINKING: A REVIEW OF SOME STUDIES.


THE PROFESSIONAL EDUCATION OF SPEECH CLINICIANS IN THE PUBLIC SCHOOLS.


THE USE OF NUMBER RODS IN MATHEMATICS.

THE USE OF NUMBER RODS IN MATHEMATICS.


TOWARD A BROADER CONCEPT OF THE ROLE OF THE SPECIAL CLASS FOR EMOTIONALLY DISTURBED CHILDREN.


NOISE CONDITIONS IN NORMAL SCHOOL CLASSROOMS.


THE CAPACITIES OF CHILDREN.

THE CAPACITIES OF CHILDREN.


DIRECTION FOR FUTURE ACTION.

DIRECTION FOR FUTURE ACTION.


CUTTING: A KINESTHETIC TOOL FOR LEARNING.


FAMILY PLANNING.

FAMILY PLANNING.


DIFFERENTIAL DIAGNOSIS OF THE ANAEMIAS.

DIFFERENTIAL DIAGNOSIS OF THE ANAEMIAS.


NON-OFFICIAL HEALTH INSTITUTION IN RURAL AREAS.


FERTILITY CONTROL IN COMMUNIST CHINA.

FERTILITY CONTROL IN COMMUNIST CHINA.


SURGICAL CONSIDERATIONS IN THE AGED.

SURGICAL CONSIDERATIONS IN THE AGED.


POSTOPERATIVE MANAGEMENT OF THE AGED PATIENT.


PSYCHIATRIC ASPECTS OF ANESTHESIA WITH OLDER PEOPLE.


EVALUATION AND TREATMENT OF PULMONARY PROBLEMS IN THE AGED SURGICAL PATIENT.


GERIATRIC ANESTHESIA. INTRODUCTION.

GERIATRIC ANESTHESIA. INTRODUCTION.


INHALATION ANESTHESIA IN THE AGED.

INHALATION ANESTHESIA IN THE AGED.


PHYSIOLOGIC CHANGES IN THE AGED.

PHYSIOLOGIC CHANGES IN THE AGED.


FREUD AND JUNG: AN ENCOUNTER.

FREUD AND JUNG: AN ENCOUNTER.


REGIONAL ANESTHESIA FOR THE AGED.

REGIONAL ANESTHESIA FOR THE AGED.


AN EVALUATION OF THE APPLICABILITY OF THE DAY HOSPITAL IN TREATMENT OF ACUTELY DISTURBED PATIENTS.


ON THE FORMATION OF OBJECT-RELATIONS AND IDENTIFICATIONS OF THE KUBBUTZ CHILD.


DAY HOSPITAL SERVICE IN AN OPEN PSYCHIATRIC HOSPITAL; FOUR YEARS FOLLOW UP.


BLOOD ACETALDEHYDE LEVELS IN AFFECTIVE DISORDERS.


IMPAIRED INTELLIGENCE: AN ANALYSIS OF ESSENTIAL ELEMENT AND TYPES.


THE PH READINGS OF SALIVA AND DENTAL PLAQUE OF TOOTH SURFACES BEFORE AND AFTER GLUCOSE RINSES BY SCHOOL CHILDREN IN A HIGH AND LOW CARIES INCIDENCE AREA IN THE REPUBLIC OF SOUTH AFRICA.


THE REHABILITATION OF A DENTIST.

THE REHABILITATION OF A DENTIST.


THE RELATION OF INFLAMMATION TO THE MOLECULAR STRUCTURE OF CARBON COMPOUNDS SOLUBLE IN THE FLUIDS OF THE BODY. The peritoneal, like the pleural cavity, gives opportunity to measure with adequate accuracy the activity of inflammatory reactions defined by movement of fluid within the cavity, by migration of leucocytes into it, and by exudation of proteins from the plasma. The activity of inflammatory reactions caused by saccharides or by alcohols that were tested varied in accord with their molecular weight, the osmotic pressure maintained by solutions of corresponding concentration, their boiling point, or by other colligative properties. Blood serum or globulin in the concentration with which it occurs in blood serum injected into the peritoneal cavity caused changes which differed little from those caused by physiological salt solution. Protein with molecular weight as low as that of cytochrome C (12,000) or ovalbumin (45,000) when in dilute solution (1 per cent) were rapidly absorbed, whereas trypsin and chymotrypsin under the same conditions caused very active inflammatory reactions because they set free amino acids and perhaps polypeptides with amino acids in short chains. The activity of inflammatory reactions caused by carbon compounds soluble in body fluids varied in accord with their colligative properties.


QUANTITATION OF TRANSPLANTATION IMMUNITY. I. METHOD. A technique for in vivo quantitation of transplantation immunity has been presented. Known numbers of H(3)-thymidine-labeled lymphoid cells were injected intravenously into isologous or homologous recipients. The total radioactivity in host spleens was counted at different time intervals. The rate of isotope disappearance from the spleen was exponential to 0.5 per cent of the dose or less. In isologous recipients, the calculated half-life of labeled cells was 82 hours; in homologous recipients it was 40 hours; and in presensitized homologous hosts it was 18 hours. The technique is a highly reproducible, precise, and sensitive measure of transplantation immunity.