An adaptation of quality control chart methods to bacterial vaccine potency testing.


Preliminary evidence that bacterial flagella are not "polysaccharide twirls".


The effect of aeration on the growth of Aerobacter aerogenes and Escherichia coli, with reference to the Pasteur mechanism.


An improved CO2 cabinet for low temperature storage of infectious agents with gaseous CO2 excluded from the specimen compartment.


Response of the Swiss albino mouse to the virus of Newcastle disease.


Electron microscopic observations of flagellation in some species of the genus Treponema Schaudinn.


Studies on nicotinamide derivatives.

Studies on nicotinamide derivatives.


The fermentation of inositol.

The fermentation of inositol.


The utilization of nitrogen in various compounds by Clostridium pasteurianum.


Adaptations in growth factor requirements for lactic acid bacteria.


Nitrogen fixation and hydrogenase in various bacterial species.


Nutrition studies of two variants of Lactobacillus gayoni.


The growth of bacteria in a charcoal-cellophane system.


Nutritional requirement for the production of formic hydrogenylase, formic dehydrogenase, and hydrogenase, in Escherichia coli.


A solid medium for detecting colonial variants of Pasteurella pestis.


Fructose utilization by Pseudomonas putrefaciens.


The fixation of carbon dioxide by growing and nongrowing yeast.


The substitution of starch, glycogen, and dextrin for natural body fluids in the cultivation of Streptobacillus moniliformis.


Attempts to increase the heat resistance of the spores of a putrefactive anaerobe by selection.


Streptomycin resistance; a genetically recessive mutation.


Studies on heat resistance. IV. Sporulation of Bacillus cereus in some synthetic media and the heat resistance of the spores produced.


Studies on the variation of Bacterium tularense.


Prophylaxis of experimental gas gangrene in mice.


The influence of vitamin B12 on oxidation by a mutant strain of Escherichia coli.


Vitamin requirements for lipase production by Candida lipolytica.


The action of streptomycin. V. The formation of citrate.


The fermentation of purines by Micrococcus lactilyticus.


The influence of the metabolic state and of the medium on carbon dioxide fixation by Serratia marcescens.


Variation in morphology of colonies of lactobacilli.


The action of streptomycin on the respiration of Streptomyces griseus.


A new bacteriophage active against a lactic streptococcus.


A case of probable botulism due to wound infection.


Distribution of egg white proteins in chicken blood serum and egg yolk.


Metabolism of cis-testosterone androstanediol-3 beta, 17 beta, and etiocholanol-17beta-one-3 in vivo.


Effect of deficiency of B vitamins on the metabolism of tryptophan by the rat.


Apoerythein in saliva.

Apoerythein in saliva.


Anterior pituitary extract and liver metabolism.


The inhibition of tobacco mosaic virus by synthetic lysine polypeptides.


Factors influencing the combination of insulin with muscle from normal rats.


Phosphate metabolism of the isolated rat diaphragm.


A crystalline bean seed protein in combination with phytic acid.


Effects of pH, bicarbonate, and cofactors on the metabolism of brain suspensions.


Route of absorption of free fatty acids and triglycerides from the intestine.


Acetic acid metabolism in Torulopsis utilis. III. Metabolic connection between acetic acid and various amino acids.


The detection and estimation of 2-ketohexonic acids.


Chromatographic purification and serologic studies of a beef heart lecithin.


Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast.


The assimilation of nucleic acid derivatives and related compounds by yeasts.


The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid.


Studies on the hazard involved in use of C14. III. Long term retention in bone.


The assimilation of ammonium and nitrate ions by tobacco plants.


The multiplication of tobacco mosaic virus in the host tobacco plant.


Isolation of chondroitin sulfate-S35 from articular cartilage of rats.


The alkali-catalyzed conversion of glucose into fructose and mannose.


Methylation of nicotinamide with soluble enzyme system from rat liver.


Synthesis of enantiomeric alpha-phosphatidic acids.


Participation of phospholipides in lymphatic transport of absorbed fatty acids.


Intramolecular nature of the oxidative inactivation of crystalline beta-amylase.


The requirement for coenzyme A in the enzymatic synthesis of hippuric acid.


Utilization of non-specific nitrogen sources by the adult protein-depleted rat.


Relationship of C14o2 fixation to carbohydrate metabolism in retina.


Isoleucine and valine metabolism of Escherichia coli. I. Growth studies on amino acid-deficient mutants.


Isoleucine and valine metabolism of Escherichia coli. II. The accumulation of keto acids.


Studies on thiamine analogues. I. Experiments in vivo.


Studies of the metabolism of beta-C14-dl-adrenalin.


Synthesis and properties of pantothenic acid diphosphate.


Synthesis of pantolactone phosphate and its effect on growth of microorganisms.


Some properties of coenzyme A.

Some properties of coenzyme A.


An improved enzymatic assay for coenzyme A.


Determination of diethylstilbestrol and its glucuronide in urine.


On the conversion of palmitic acid to stearic acid in animal tissues.


Inhibition of diphosphopyridine nucleotide-requiring enzymes by nicotinamide.


The synthesis of radioactive cholesterol and fatty acids in vitro.


Microestimation of magnesium in body fluids.


The ultimate site of skeletal deposition of strontium and lead.


Some imidazo-1,2,3,-triazines and their biological relationship to the purines.


Further studies of the synthesis of protein by Escherichia coli.


Concerning the relation of the Krebs cycle to virus propagation.


Isotopic acetate and isovalerate in the synthesis of ergosterol by Neurospora.


The incorporation of C14-orotic acid into nucleic acid pyrimidines in vitro.


Excretion in reptiles. IV. Nitrogenous constituents of the excreta of lizards.


The resolution of amino acids by asymmetric enzymatic synthesis.


Growth experiments with thioether derivatives of cysteine and homocysteine.


A method for the determination of gentisic acid in serum.


A note on the acetylation of sulfur amino acids by liver and kidney.


Some new biosynthetic penicillins.

Some new biosynthetic penicillins.


On the nature of ascorbic acid oxidase.

On the nature of ascorbic acid oxidase.


Mechanism of the conversion of ornithine into proline and glutamic acid in vivo.


The metabolism of radioactive strontium in adult, young, and rachitic rats.


The influence of folic acid on methionine metabolism.


The metabolic activity of the alpha-hydrogen atom of lysine.


Evidence on the metabolism of alpha-acetyllysine.


Purine incorporation into pentose nucleotides of the rat.


The niacin-tryptophan relationship in the metabolism of Xanthomonas pruni.


Replacement of the pyruvate oxidation factor by carbon dioxide.


Effect of incomplete hydrolysis on microbiological determination of amino acids.


Conversion of C14, C13, labeled n-valerate to rat liver glycogen.


Enzymatic decarboxylation of aspartic acid to alpha-alanine.


Determination of aspartic and glutamic acids by enzymatic decarboxylation.


Microdetermination of purines and pyrimidines in biological materials.


Purine and pyrimidine content of the nucleic acids of nuclei and cytoplasm.


Gluconokinase and the oxidative path of glucose-6-phosphate utilization.


The determination of free and total amino acids in rat tissues.


A new procedure for fractionation of mixtures by solvent distribution.


Studies on the role of cysteine in the activation of folic acid conjugase.


Further studies on tryptophan-niacin-pyridine nucleotide relationships.


A microspectrophotometric method for the determination of cytochrome oxidase.


A crystalline, active oxidation product of alpha-chymotrypsin.


Glycerate-2,3-diphosphatase.


The oxidation of reduced diphosphopyridine nucleotide in green peas.


Choline acetylase. V. Esterifications and transacetylations.


Effect of thyroxine and thiouracil on S35 deposition in articular cartilage.


Enzymatic hydrolysis of steroid hormone esters by blood serum.


Studies on the biosynthesis of ovalbumin.


Activation of methionine for transmethylation.


The effects of fat deficiency upon enzyme activity in the rat.


Studies on the detoxification of 2-methyl-1,4-naphthoquinone in rabbits.


A study of the measurement of 4-pyridoxic acid in urine.


Chemical interferences in cellular metabolism; cinnamate effects.


Glutamine, glutamic acid, ammonia administration, and tissue glutamine.


The enzymatic synthesis of adenylic acid; adenosinekinase.


Formate fixation in pyruvate by Escherichia coli.


Arginase, adenosinepyrophosphatase, and rhodanese in regenerating rat liver.


Studies on the mechanism of acetate oxidation by Escherichia coli.


Studies on the mechanism of acetate oxidation by micrococcus lysodeikticus.


The rate of transfer of phosphorus across the red blood cell membrane.


Glycolysis and phosphate fractions of red blood cells.


Synthesis of nicotinamide mononucleotide by human erythrocytes in vitro.


Legibility of lantern slides.

Legibility of lantern slides.


Tridimensional cytohistology.

Tridimensional cytohistology.


Color duplication of transparencies.

Color duplication of transparencies.


Visual teaching aids in medical education.


A report of the committee on Judging of Medical and Biological Motion Pictures.


An adjustable stand for camera and flash gun.


Tuberculosis of the hip joint.

Tuberculosis of the hip joint.


Prognosis in tuberculosis of the hip; an analysis of the results of treatment and of the factors which influence the end-result.


Fractures of the upper end of the tibia.


Cancer as a sequel to war wounds.

Cancer as a sequel to war wounds.


Compression arthrodesis of the ankle and shoulder.


Trochanteric fractures; a review of 110 cases treated by nail-plate fixation.


Actinomycosis of bone with special reference to infection of vertebral column.


Advanced actinomycosis of the spine treated with penicillin and streptomycin; report of a case.


Infection of wounds with actinomyces.

Infection of wounds with actinomyces.


Pectoralis minor transplant for paralysis of the serratus anterior.


A case of renal rickets simulating "metaphysial dysostosis".


Tenodesis of subclavius in the treatment of recurrent dislocation of the sterno-clavicular joint.


Fractures of the radial head with distal radio-ulnar dislocation; report of two cases.


An atypical case of infantile cortical hyperostoses.


Tarsal movements.

Tarsal movements.


The movements of bones and joints; the mechanical structure of articulating cartilage.


Citric acid and calcium metabolism.

Citric acid and calcium metabolism.


Specimens from the Hunterian Collection. 3. The genicular arteries (specimen S142 A).


An improved splint for radial (musculospiral) nerve paralysis.


An improved stapler.

An improved stapler.


Frederick Augustus Dixey.

Frederick Augustus Dixey.


A. S. BLUNDELL Bankart 1879-1951.

A. S. BLUNDELL Bankart 1879-1951.


SYMPOSIUM on congenital dislocation of the hip.


Let's face the facts.

Let's face the facts.


Hydrocolloid impressions for inlays and fixed bridges.


A study of the fulfillment of essential dental needs in a community.


AMMONIATED dentifrices.

AMMONIATED dentifrices.


Influence of adrenal hormones on the distribution and concentration of alkaline phosphatase in chick embryo cells cultivated in vitro.


A theoretical model for phosphorus transport during early embryonic growth.


The reaction between actomyosin and various nucleotides and phosphates as followed by ultraviolet absorption.


Destruction of the pinnae of white mice by high intensity air-borne sound.


The influence of light upon the action of ultraviolet on Paramecium aurelia.


Linear growth responses of boys to prolonged treatment with chorionic gonadotropin.


Distribution of chorionic gonadotropin in mother and fetus at various stages of pregnancy.


The behavior of free-weighted actomyosin threads under pressure.


Prolonged treatment of a case of periarteritis nodosa with ACTH; the effective dose as measured by metabolic balances.


The response of patients with bronchial asthma to epinephrine and to adreno-corticotropic hormone.


Studies on cell enzyme systems. V. The effect of temperature on the Michaelis constant for milk aldehyde dehydrogenase.


The metabolism of ethinyl estradiol in man.


The effect of iodoacetate on the vertebrate retina.


Enzyme systems in Tetrahymena geleii S. II. Acetylcholinesterase activity; its relation to motility of the organism and to coordinated ciliary action in general.


Effect of 2,4-dinitrophenol on the differentiation of the slime mold Dictyostelium discoideum.


Studies on the conversion of testosterone to urinary 17-ketosteroids in normal human males and males with hepatic and other diseases.


Studies on the metabolism of testosterone in normal women in different phases of the menstrual cycle.


The iodine vapor stained vaginal smear; its use in office practice.


Seasonal variation of Qo2 of rat brain tissue.


Urinary prolactin excretion in man.

Urinary prolactin excretion in man.


Metabolic effects of ACTH upon preexisting diabetes mellitus.


Sexual trends in female pseudohermaphrodism.


Irradiation of the pituitary in the treatment of malignant exophthalmos.


The treatment of adolescent acne with topical application of estrogens.


The scintillation counter in clinical studies of human thyroid physiology using I131.


Growth hormone and experimental diabetes.


Pituitary necrosis and diabetes mellitus.


The collapse produced by venous congestion of the extremities or by venesection following certain hypotensive agents.


Effects of adrenocorticotropic hormone and cortisone in patients with tuberculosis.


Aging as a factor in the renal hemodynamic changes induced by a standardized pyrogen.


Urinary excretion of choline metabolites following choline administration in normals and patients with hepatobiliary diseases.


The effect of low concentrations of calcium and phosphate salts on bacterial luminescence intensity.


Studies in disorders of muscle. VII. Clinical manifestations and inheritance of a type of periodic paralysis without hypopotassemia.


The nephrotic syndrome in children. An interpretation of its clinical, biochemical, and renal hemodynamic features as variations of a single type of nephron disease.


Respiratory regulation during exercise in unconditioned subjects.


The effect of norepinephrine upon pulmonary arteriolar resistance in man.


Blood levels of adenine nucleotides.

Blood levels of adenine nucleotides.


Butanol-extractable iodine of serum.

Butanol-extractable iodine of serum.


OLIVER S. Strong, 1864-1951.

OLIVER S. Strong, 1864-1951.


Quantitative effects of the peripheral innervation area on nerves and spinal ganglion cells.


Biochemical and physiological differentiation during morphogenesis. XIII. Functional maturation of the motor cortex of the fetal guinea pig as judged by the appearance of muscular responses to electrical stimulation of the cortex.


The organization of the nervous system of Ariolimax columbianus.


Organization of the fasciculus solitarius in man.


A cytological study of transneuronal atrophy in the cat and rabbit.


The branching of nerve fibers in human cutaneous nerves.


The motor cell columns of the lumbo-sacral spinal cord of the cat.


The role of alkaline phosphatase in osteogenesis. The role of alkaline phosphatase in osteogenesis has been investigated by histochemical techniques with particular attention to its relationship to phosphate metabolism and matrix elaboration. The upper tibial epiphysis mainly, and other epiphyses as well of growing rabbits, and the costochondral junctions of newborn human beings were studied, as were bone grafts in growing rabbits. The findings in the newborn human beings were identical with those in the rabbits. Phosphatase activity and free phosphate localization do not universally coincide. The enzyme appears to be intimately related to preosseous cellular metabolism and to the elaboration of a bone matrix that is chemically calcifiable. It remains possible, however, that phosphatase may be in some way involved in making inorganic salts available to the calcifiable matrix. If this function does exist it is a secondary one, since the elaboration of bone matrix, which is always associated with phosphatase activity, can and does occur in the absence of calcification. Calcification may occur later, in the absence of the enzyme. There is evidence to suggest that cartilage matrix is utilized in the formation of bone matrix. Phosphatase is physiologically active only in the presence of living cells. Where it is demonstrable in the absence of living cells, as in the cartilage remnants of the metaphysis, it appears to be physiologically inactive. Since phosphatase is temporarily inactivated in weakly acid media, and readily reactivated by alkaline solutions it is possible that the enzyme might survive in a physiologically inactive state in weakly acid tissues, and yet remain capable of histochemical demonstration in vitro in an alkaline medium. Phosphatase is not related to the disappearance of chondroitin sulfate.


Age of the host and other factors affecting the production with urethane of pulmonary adenomas in mice. Young, rapidly growing mice are greatly more responsive to the adenoma-inducing influence of urethane than are those just arriving at maturity. This is manifest both in the proportion of animals developing the tumors and in their number per individual. An amount of urethane per gram body weight which suffices to induce adenomas in only an occasional 8-week-old animal will cause them to appear in quantity in more than half the 3-week-old mice injected. There is an almost absolute inverse correlation between the rate of growth of the pulmonary tissue between the ages of 2 and 10 weeks and the response to urethane in terms of adenomas. Hence the conclusion seems justified that the natural proliferative activity of the alveolar cells during youth plays a major part in the formation of the tumors. After the 6th week the age differences become relatively slight, yet there is reason to think that they continue in some degree as life goes on. Urethane has no effect to promote multiplication of the cells it has rendered neoplastic, its whole role being to initiate neoplastic change. The abnormalities induced by urethane in the nucleus of normal and neoplastic cells, as observed by previous workers, have suggested that the substance brings about the adenomatous state by acting upon the nucleus. But colchicine, also a karyolytic poison causing pronounced nuclear changes, does not alter in the least the yield of adenomas to urethane when administered concurrently. Nor does fasting influence the yield, though it markedly reduces mitotic activity. The meaning of these facts is discussed.


Radioautographic visualization of sulfur-35 disposition in the articular cartilage and bone of suckling rats following injection of labeled sodium sulfate. The localization of sulfur-35 administered intraperitoneally as sodium sulfate to 7-day-old rats was determined by radioautography of sections of humeri and tibia-knee-femur combinations removed 24, 48, 96, 216, and 290 hours after injection of this isotope. Radioautography of sections of bone and cartilage that had been fixed in formalin indicated that the tracer isotope was present throughout the entire epiphysis. Its concentration therein was highest initially at the epiphyseal-diaphyseal junction where the more mature cartilage cells were present. By the 96th hour post injection the sulfur-35 had become more uniformly distributed in the epiphyses and an even distribution of it throughout the epiphyseal cartilage was almost attained by the 216th hour post injection. As centers of secondary ossification arose in the epiphyseal cartilage, the sulfur-35 appeared to diminish in concentration and disappear from these loci. However, radioautographs of cartilage fixed in formalin saturated with barium hydroxide, instead of in formalin only, disclosed the fact that the tracer isotope was still present in these loci. When bone and bone marrow were fixed in formalin the autographs indicated the presence of sulfur-35 primarily in the periosteum. Only a negligible amount appeared to be present in the bone shaft and marrow. However, when these tissues were fixed in formalin saturated with barium hydroxide it was possible to demonstrate the presence of the tracer isotope in both bone and bone marrow.


Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis. Evidence is presented to indicate that a profound thrombocytopenia and granulocytopenia occur during the second stage of the Shwartzman phenomenon, prior to the actual onset of hemorrhage in the prepared skin areas. These hematologic alterations appear to be due to accumulation of the cells mentioned in the capillary bed of the lungs and perhaps other internal organs. This seems to be consequent on certain changes in the platelets and polymorphonuclear leucocytes, which result in the formation of clumps of these elements. In skin areas prepared for the Shwartzman phenomenon, the capillaries and small veins become occluded by masses of platelets and granulocytes after the intravenous challenging injection has been given. Following the interruption of blood supply necrosis of the involved vessels takes place, and hemorrhage occurs later where the vessel walls have lost their integrity.


Joint action of a chemical carcinogen and a neoplastic virus to induce cancer in rabbits; results of exposing epidermal cells to a carcinogenic hydrocarbon at time of infection with the Shope papilloma virus. Areas of rabbit skin previously rendered hyperplastic with turpentine were scarified, inoculated with the Shope papilloma virus, and covered with a dressing that contained 20-methylcholanthrene (MC) or 9:10-dimethyl-1:2-benzanthracene (9:10). The dressing was left on until healing had been well completed, a matter of 5 to 7 days. The papillomas which subsequently arose often appeared later, were fewer, and remained less vigorous than those due to the action of virus alone, but throughout several months they appeared to differ from these in no other ways. Then, more or less abruptly, the large majority became carcinomatous, frequently at several situations, whereas with few exceptions the control growths underwent no such alteration. The cancers were of the sorts ordinarily deriving, by secondary change, from epidermal cells infected with the virus. Collateral data have made plain that the hydrocarbons acted in their carcinogenic capacity to bring on the cancers. Indeed in control tests 9: 10 sometimes conferred latent neoplastic potentialities on uninoculated epidermis exposed to it while healing after scarification, a fact disclosed months later by painting these expanses with chloroform until hyperplasia occurred. Under the promoting influence of this agent papillomas formed which had the distinctive morphology of those induced by the chemical carcinogens. So strong and enduring were the effects of MC and 9:10 as to cause cancers to arise from many virus papillomas which were retrogressing after months of proliferation, that is to say under circumstances ordinarily unfavorable to malignant change. The facts justify the conclusion that the virus and the hydrocarbons acted jointly and in their carcinogenic capacities.


Lymphoid lesions in poliomyelitis.

Lymphoid lesions in poliomyelitis. Examination of 50 autopsied cases of human poliomyelitis showed prominent hyperplastic and inflammatory changes in the lymphoid tissues of 41, the most frequent and severe lesions observed save those in the central nervous system. Histologically the germinal centers showed prominent degenerative and regenerative alterations, fluid transudation, giant cell formation, and rare inclusion bodies, all consistent with virus effects. Treatment of mice with x-rays, aminopterin, and adrenocorticotropic hormone increased poliomyelitis infections following intraperitoneal injection of MEF strain virus, potentiated by intracerebrally injected corn starch. This was ascribed to the damage to lymphoid tissues produced by these agents. On the basis of combined morphologic and virus studies, the presence of gastrointestinal, lymphoid, nervous tissue, and nerve cell defense barriers to poliomyelitis virus is suggested. Use of irradiated mice might prove useful in primary isolation of virus from human poliomyelitis.


Antimicrobial agents in the prevention of dietary hepatic injury (necrosis, cirrhosis) in rats. The effect of various antimicrobial agents, such as aureomycin, terramycin, streptomycin, chloromycetin, penicillin, polymyxin, and sulfaguanidine on the development of massive dietary necrosis of the liver in rats has been studied. Delay in the production of hepatic necrosis was obtained from aureomycin and, to a lesser extent, from terramycin and streptomycin. Indication of temporary protection was shown by sulfaguanidine, whereas chloromycetin, polymyxin, and penicillin were not protective. B(12), added alone, or in combination with aureomycin, to the basal experimental diet had no influence on the development of hepatic necrosis. A combination of pectin with streptomycin enhanced the protective effect of the antibiotic. All the antimicrobial agents tested, without relation to their effect on hepatic necrosis, produced temporary stimulation of growth in the experimental animals. The beneficial effect of aureomycin was not limited to the delay of hepatic necrosis but manifested itself also in the prevention of hepatic cirrhosis in rats fed a low protein (casein)-high fat diet. In contrast to control animals showing the usual combination of cirrhosis and renal changes, the rats receiving supplements of aureomycin were free of both cirrhosis and renal changes. The rats receiving aureomycin took more food in and gained weight. No microscopic alterations were seen in the pancreas of the control rats with cirrhosis. In both groups of experiments (necrosis and cirrhosis) the antimicrobial agents, with the exception of penicillin, were given mixed with the food. Their possible effect on the intestinal flora is discussed.


Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis. Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.


Conversion of plasma protein to tissue protein without evidence of protein breakdown; results of giving plasma protein labeled with carbon 14 parenterally to dogs. Labeled plasma proteins obtained from donor dogs, previously fed epsilon-C(14)-dl-lysine, have been given intravenously to recipient dogs. The disappearance of labeled globulin from the plasma at a rate considerably faster than albumin has been confirmed. Evidence suggesting that the mass of protein in solution in the extravascular, extracellular fluid is approximately equal to the plasma proteins in circulation has been derived from a study of the dilution of labeled plasma protein by repeated injections of non-labeled plasma protein. In a period of 7 days the transfer of C(14) from plasma to tissue proteins amounted to between 30 and 40 per cent of the activity in the labeled plasma protein injected intravenously. The conversion was accompanied by a very small loss of activity in the urine and expired air and the activity remained in the lysine residue of the liver and probably of other tissues. The data presented favor the view that plasma proteins are utilized in the body economy after partial catabolism within the cell area and provide no evidence of complete breakdown to the amino acid level.


Endocrines and their relation to influenza virus infection. Treatment with testosterone increases proliferation of influenza virus as well as protein anabolism. A relative lack of testosterone caused by castration is associated with a diminished rate of virus growth. When protein catabolism is increased by ACTH or cortisone, the rate of virus proliferation decreases. These results suggest the existence of a correlation between alterations of protein metabolism and virus proliferation.


Variability of BCG strains (Bacillus Calmette-Guérin). Three different cultures of BCG propagated for over 2 years in a liquid medium containing Tween 80 and albumin were found to differ in several of their intrinsic properties. Cultures of the three strains were found to consist of morphologically heterogeneous populations-each culture being made up of three main colonial types-spreading, intermediate, and non-spreading. The percentage distribution of colonial types was characteristic for each culture and remained constant during cultivation in liquid media. Injection of the various cultures into mice and guinea pigs resulted in a self-limited disease. The distribution, extent, and duration of the lesions were also characteristic for each culture. Both the spreading and non-spreading substrains derived from the various cultures exhibited the degree of attenuation of virulence characteristic of the parent strain.


A new member of the psittacosis-lymphogranuloma group of viruses that causes infection in calves. From portions of intestine and feces of apparently normal calves, a virus that produces elementary bodies was procured in guinea pigs and in embryonated eggs. Morphologically and tinctorially this virus closely resembled members of the psittacosis-lymphogranuloma group of viruses and it shared a common antigen or antigens with them. Comparison of serological, pathogenic, and other properties indicated that this virus from calves is a new member of the psittacosis-lymphogranuloma group and in keeping with classification practices it is provisionally named Miyagawanella bovis. Miyagawanella bovis when fed to experimental calves established an infection in the intestinal tract that resembled the inapparent infection seen in natural cases but failed to produce evident disease. Ability of the virus to infect experimental animals by feeding, and its presence in feces of infected animals indicate its natural mode of spread. This method of dissemination and persistence of virus for long periods of time in infected animals suggested the virus should be widespread and more than 60 per cent of the calves in the vicinity of lthaca were found to be infected.


The nature and significance of changes in adrenal cytology, weight, and cortical/medullary ratio in experimental renal hypertension and clinical hypertension. There is a direct proportionality between the degree of adrenal and that of cardiac enlargement in experimental renal hypertension. This is evidence for the participation of the adrenal to an extent dependent on the severity of the hypertension as reflected in the degree of cardiac hypertrophy. The greater part of the weight increase of the adrenal is due to growth of the cortex. However, the relative degree of medullary growth exceeds that of cortical growth. There is evidence of medullary hyperplasia, but the cortical growth may be due to cell hypertrophy alone. In view of the known relationship between prolonged skeletal muscle work and the size of the adrenals, in which there is likewise a relatively greater growth of the medulla, the possibility that adrenal growth in experimental renal hypertension is a consequence of the metabolic demand of increased heart muscle work must be considered. The hyperplastic, hypertrophic medulla of the renal hypertensive rat is presumed to be producing increased amounts of a hormone whose action is not known. The adrenal medulla is not necessary for the development of moderate renal hypertension though this does not exclude the possibility that it may be involved somehow in the maintainance of the hypertensive state. Large, periodic-Schiff-positive, hyaline droplets are found in the cytoplasm of adrenal cortical cells with nuclear evidence of active function. There is some evidence that these indicate hypophyseal stimulation. Similar particles are found in the medulla, suggesting an interrelationship between the two parts of the adrenal. The close resemblance of changes in adrenal weight, nuclear/cytoplasmic ratio, and nuclear and cytoplasmic structure, indicates that similar physiological and morphological controlling mechanisms are involved in the pathogenesis and maintainance of experimental renal hypertension and clinical essential hypertension.


Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys. The white cell count, total protein, gamma globulin, and percentage of gamma globulin in the cerebrospinal fluid of monkeys with acute disseminated encephalomyelitis produced by the injection of brain emulsions with adjuvants have been studied. The acute phase of the disease is characterized by a rise in the white cell count, total protein, and gamma globulin in the cerebrospinal fluid. In some instances the percentage of gamma globulin, to the total protein may be normal while in others it is elevated. As the acute process subsides, the total protein declines and animals frequently show an increase in the percentage of gamma globulin to total protein. The relation of the cerebrospinal fluid findings in acute disseminated encephalomyelitis in the rhesus monkey to those in human multiple sclerosis is discussed.


Mechanism of proteinuria. IV. Effect of renin on hemoglobin excretion. 1. Administration of renin to the rat causes an increase in the glomerular permeability to hemoglobin and a decrease in tubular absorption of this substance as measured by functional methods. 2. Morphologic examination in the rat and in the rabbit reveals an increased concentration of hemoglobin in the tubular lumina, confirmatory evidence of increased permeability. However, there is no significant effect upon the formation of hemoglobin droplets within the renal cells. 3. By analogy with the events observed in neutral red "secretion," it is suggested that hemoglobin is absorbed by both a "direct" and an "indirect" mechanism and that renin administration affects or depresses the "direct" mechanism only.


The statistical analysis of slope-ratio assays.


Significance of calcium in the fruiting of Chaetomium species, particularly Chaetomium globosum.


The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice. A further study has been made of the relationship of reactions of the Krebs cycle to the propagation of influenza virus. By the administration of sublethal doses of sodium fluoroacetate which were found to increase the concentration of citrate in the mouse lung, it was possible to demonstrate a blocking of the citric acid cycle in that organ. Further, the intraperitoneal administration of these concentrations of fluoroacetate was found to inhibit markedly the propagation of influenza, Type A, virus in the lungs of mice. The inhibition was observed when the fluoroacetate was administered 15 minutes, 6 hours, or 12 hours after the mice were inoculated with virus. This effect was also demonstrable when the concentration of the viral inoculum was varied over a range of virus titers from 10(3.5) to 10(6.5). Sodium fluoroacetate was found to have no effect in vitro on the infectivity or hemagglutinating property of the virus. The significance of these findings with regard to chemotherapy and to the mechanism of viral synthesis is described.


Polysaccharidases of group A streptococci.


The virulence of Haemophilus pertussis for mice by the intranasal route.


Note on the relation between LD50 and average time to death in 25 strains of H. pertussis.


The isolation of deoxyribonucleic acid from virulent and avirulent strains of Haemophilus pertussis.


Shaking apparatus for the aeration of bacterial cultures.


The intracellular growth of fowl-plague virus; a phase-contrast and electron microscopical study of infected tissue cultures.


Cell structure of Corynebacterium diphtheriae.


Effect of cultural conditions on bacterial cytology.


The identity of Proteus hydrophilus Bergey et al. and Proteus melanovogenes Miles & Halnan, and their relation to the genus Aeromonas Kluyver & van Niel.


The mouse pathogenicity and toxicity of Proteus vulgaris.


Isolation of a bacterium, producing propionic acid, from the rumen of sheep.


The mechanism of propionic acid formation by Veillonella gazogenes.


The mechanism of propionic acid formation by propionibacteria.


The ability of single phage particles to form plaques and to multiply in liquid cultures.


An antibiotic assay tray.

An antibiotic assay tray.


Nitrification of oxime compounds by heterotrophic bacteria.


A reinvestigation of the root-nodules of species of Elaeagnus, Hippophae, Alnus and Myrica, with special reference to the morphology and life histories of the causative organisms.


A selective medium for Bacillus anthracis.


The adsorption of cetyltrimethylammonium bromide by bacteria, its action in releasing cellular constituents and its bactericidal effects.


Electron microscopy of bacteria treated with cetyltrimethylammonium bromide.


Observations on the value of the Bordet-Gengou medium for the cultivation of Haemophilus pertussis.


The assay of vitamin B12. I. Factors affecting the response of Lactobacillus lactis Dorner ATCC 8000 to vitamin B12.


The composition and structure of isolated chromosomes. 1. The preparation of isolated chromosomes from liver, kidney, and pancreas has been described. 2. It has been shown that there is no gross cytoplasmic contamination in these preparations. 3. In a microscopic study of isolated chromosomes the same chromosomes have been found in different tissues of the same organism. Since individuality is one of the main characteristics of chromosomes, there can be little doubt that the preparations do, in fact, contain isolated chromosomes. 4. A quantitative study of staining with crystal violet shows that this basic dye competes with histone for the phosphoric acid groups of the DNA in chromosomes. The displacement of histone by protamine has been demonstrated. 5. Preparation of histone-free chromosomes has been described. Removal of histone does not affect the microscopic appearance of chromosomes. 6. The non-histone or residual protein has been prepared from histone-free chromosomes. The quantity of residual protein in a preparation of chromosomes is correlated with the amount of cytoplasm in the cells from which the chromosomes were prepared. 7. The microscopic appearance of chromosomes depends upon the association of DNA with residual protein. 8. Evidence has been given that in a chromosome there are two DNA-containing nucleoproteins; in one DNA is combined with histone, and in the other it is combined with residual protein.


Mechanisms involved in fibrin formation. That the role of thrombin in the conversion of fibrinogen to fibrin is essentially enzymatic, is established not only by the minute amounts of thrombin which are effective but also by the complete independence of fibrin yields and thrombin concentrations over a very wide range of thrombin dilutions and clotting times. The thrombin-fibrinogen reaction, in the phase beyond the "latent period" at least, seems fundamentally "first order." Technical requirements of the experiments leading to these conclusions include: (1) a highly purified (e.g. 97 per cent "clottable") fibrinogen, (2) absence of traces of thrombic impurities in the fibrinogen, (3) absence of fibrinolytic protease contaminant of the thrombin and the fibrinogen, and (4) sufficient stability of the thrombin even at very high dilutions. Four conditions affecting thrombin stability have been investigated. Fibrin yields are not significantly modified by numerous experimental circumstances that influence the clotting time, such as (1) temperature, (2) pH, (3) non-specific salt action due to electrical (ionic) charges, which alter the Coulomb forces involved in the fibrillar aggregation, (4) specific ion effects, whether clot-accelerating (e.g. Ca(++)) or clot-inhibitory (e.g. Fe(CN)(6)''''), (5) occluding (adsorptive) colloids, which have a "fibrinoplastic" action, e.g. (a) acacia and probably (b) fibrinogen which has been mildly "denatured" by salt-heating, acidification, etc. The data with which several European workers have attempted to substantiate the idea of a two-stage thrombin-fibrinogen reaction with an intermediary "profibrin" (allegedly partly "denatured") have been reanalyzed with controls which lead us to very different conclusions, viz. (1) denaturation and fibrin formation are independent; (2) partial denaturation is "fibrinoplastic" (see above); and (3) conditions of strong salinity and acid pH (5.1) usually do not completely prevent the thrombin-fibrinogen reaction but merely prolong the "latent" phase and lessen the time required for completion of essentially the same reaction (fibrin polymerization) when more favorable clotting conditions are restored. Thus, our experiments advance the modern concepts concerning the coagulation mechanisms along lines that, for the most part, agree with those of the Harvard physical chemists, and we oppose the European views concerning a two-stage reaction, "profibrin," and "the denaturase theory" of clotting.


Active transport into the human erythrocyte; evidence from comparative kinetics and competition among monosaccharides. 1. Applicability of the previously postulated active transport system for conveying glucose into the human red cell was tested in connection with a number of related substances, comprising 6-carbon aldoses and ketoses, 5-carbon aldoses, and 5- or 6-carbon polyhydric alcohols. 2. The alcohols did not perceptibly penetrate the cells; all the sugars penetrated, the rates differing, but all of the same order of magnitude. 3. All the aldoses penetrated according to the pattern previously reported for glucose, in that the rate of penetration was not directly related to the gradient, but subject to some limiting factor. 4. The ketoses penetrated approximately according to the pattern of passive diffusion. 5. When present in equal concentrations, any aldose prevented or greatly delayed the entrance of a ketose, while the ketose did not perceptibly alter the rate of aldose uptake. Within each class, similar inhibitory relations were observed. 6. Penetration of all the sugars showed a high temperature coefficient and was inhibited by the mercuric ion or p-chloromercuribenzoate; certain of the sugars showed a residual degree of penetration not thus inhibitable. 7. Penetration of the ketoses was selectively inhibited by barbital. 8. These observations are interpreted in terms of simple equilibria between the various sugars and a hypothetical carrier molecule in the membrane, with which the sugars form a complex during their passage through the membrane. Comparisons between the sugars in relation to their reactions with the carrier system are indicated.


Failure to find intercellular protoplasmic continuity in Griffithsia globulifera. A method was devised for estimtaing the electrical resistance between the cytoplasm of adjacent cells of the red marine alga Griffithsia globulifera. A very high resistance was found, which argues strongly against the existence of protoplasmic continuity in this species.


Diffractometric measurements of the tonicity volume relations of human red cells in hypotonic systems. Red cell volumes in media sufficiently hypotonic to produce partial hemolysis have been measured with a high speed hematocrit and by an improved diffraction method. A comparison of the results shows that the upward departures from the linear relation based on the van't Hoff-Mariotte law are not observed when the volumes are measured diffractometrically. Downward departures are observed at low tonicities by both methods. These results provide strong evidence that the upward departures are due to the inclusion of semirigid ghosts in the column of packed red cells which is measured when the volumes are found with the hematocrit.


Tissue hemolysins as lysin-inhibitor complexes. 1. Lytic substances are enzymatically produced at 37 degrees C. from tissue slices or homogenates (mouse liver, kidney, etc.) and appear in the medium in which the tissue fragments are suspended. Their concentration increases with the time during which the tissue is kept at 37 degrees C. (preincubation), and is accompanied by pH changes, so that the lytic activity as finally measured is a function of both the time of preincubation and of the pH. The optimum pH for lysin production is above 7.0, but the lysins, once produced, hemolyze red cells more rapidly at low pH's than at high ones. The enzyme system which produces the lysins is inactivated by heating to 100 degrees C. for 5 minutes. Sodium iodoacetate and fluoride interfere with lysin production principally by reducing the concomitant pH shift; KCN accelerates the production of lytic material in mouse liver homogenates. 2. Comparison of the lytic activity of the supernatant fluid of a preincubated homogenate with the much greater lytic activity of the substances which can be extracted from the same supernatant fluid by alcohol and ether points to these extractable substances existing in the supernatant fluid as lysin-inhibitor complexes of relatively low lytic activity. These complexes are formed enzymatically during preincubation from non-lytic complexes in the tissue. The latter may be lipoproteins, and the highly lytic ether-extractable substances may be fatty acids or their soaps. 3. The diffusibility of the lysin-inhibitor complexes is small. 4. Lytic substances which are ether-insoluble can be extracted with alcohol from tissues as well as from serum. These "lysolecithin-like" substances exist in the supernatant fluids of homogenates as lysin-inhibitor complexes. 5. Lysis of mouse red cells by substances contained in mouse tissue (liver and kidney) is often accompanied by the formation of methemoglobin and choleglobin. Mouse red cells containing choleglobin are abnormally fragile both osmotically and mechanically, and it is possible that a process involving the production of choleglobin, accompanied or followed by globin denaturation, is one which contributes towards the hemolysis which occurs in systems containing tissue slices or homogenates.


Influence of urethane and of hydrostatic pressure on the growth of bacteriophages T2, T5, T6, and T7. In 0.5 per cent NaCl, nutrient broth at 35 degrees C., urethane in a concentration of 0.4 M stops the reproduction of Escherichia coli, strain B. On dilution with 20 volumes of sterile medium, growth is resumed at its former rate after a short lag. In the one-step growth of T2, 15, T6, or T7, in the same medium at the same temperature, 0.4 M urethane, when added at the time of infection, had no apparent effect on adsorption and caused no decrease in titer throughout the latent period of the control, but completely prevented a rise in titer. If diluted 1:20 with sterile medium prior to a certain critical time in the latent period, however, bacteriophage was liberated at the same time, and in the same amount as in the control. The initial stage of apparent insensitivity to the drug lasts from the time of infection until the approximate critical times of 7 minutes with T7, T2, or T6, or 13 minutes with T5. Under the conditions described, the normal latent periods were 14, 23, 30, and 44 minutes for T7, T2, T6, and T5, respectively. At the critical times referred to above, there begins a stage characterized by complete sensitivity, rather than complete insensitivity, to 0.4 M urethane, in the sense that no active phage is subsequently liberated in continued presence of the drug. The length of this completely sensitive stage, as judged by addition of the drug at successive intervals during the latent period, extends from approximately 7 until 9 minutes after infection with T7, 7 until 15 minutes with T2 or T6, or 13 until 25 minutes with T5. When the urethane is added late in this stage of T2, a decrease in initial titer takes place as judged by assays made 40 minutes after infection, the maximum effect occurring when the drug is added between 14 and 15 minutes after infection. When added subsequently to the completely sensitive stage of each type, i.e. subsequently to 9 minutes after infection with T7, 15 minutes with T2 or T6, or 25 minutes with T5, liberation of the bacteriophage takes place in presence of the drug, but the yield is reduced, the amount of reduction being greater the sooner it is added. The yield increases as addition of the drug is delayed, but it is measurably reduced when added late in the rise period. Macroscopic lysis with T7 is delayed by 0.4 M urethane, when present from the time of infection. The delay is less with increased multiplicities of infection. A similar delay occurs with T6r at a multiplicity of 4. The application of hydrostatic pressures of 7,000 to 9,000 p.s.i. early in the latent period, within 5 to 8 minutes after infection, prevents a yield in each of the four phage types, and if maintained for lengthy periods of time a reduction in initial titer occurs. If released at various times shortly after the latent period, a rise in the titer occurred after a certain interval whose length was characteristic of the phage type. The yield was less the longer the release of pressure was delayed. When the pressure was first applied late in the latent period, large amounts of phage were liberated either under pressure or explosively when pressure was released to make the assays. Hydrostatic pressure at 6,000 p.s.i. had little effect on the rate or amount of macroscopic clearing with T7 in relatively high multiplicity of infection, when applied at the start of lysis, but slowed the rate and reduced the amount of clearing when applied shortly after infection.


The reversible heat denaturation of chymotrypsinogen. Within a restricted range of pH and protein concentration crystalline chymotrypsinogen undergoes thermal denaturation which is wholly reversed upon cooling. At a given temperature an equilibrium exists between native and reversibly denatured protein. Within the pH range 2 to 3 the amount of denatured protein is a function of the third power of the hydrogen ion activity. The presence of small amounts of electrolyte causes aggregation of the reversibly denatured protein. A specific anion effect has been observed at pH 2 but not at pH 3. Both the reversible denaturation reaction and the reversal reaction have been found to be first order reactions with respect to protein and the kinetic and thermodynamic constants for both reactions have been approximated at pH 2 and at pH 3. Renatured chymotrypsinogen has been found to be identical with native chymotrypsinogen with respect to crystallizability, solubility, activation to delta-chymotrypsin, sedimentation rate, and behavior upon being heated. Irreversible denaturation of chymotrypsinogen has been found to depend on pH, temperature, protein concentration, and time of heating. Irreversible denaturation results in an aggregation of the denatured protein.


Experiments on the role of potassium in the blocking of neuromuscular transmission by curare and other drugs. 1. Experiments with perfused frog muscles and with isolated frog muscles immersed in Ringer's solution have failed to show any effect of curare in liberating potassium from muscle tissue. This makes it difficult to suppose that the paralytic effect of curare can be attributed to cation exchange between curare and K whereby a labile potassium compound needed for stimulation is removed from the neuromuscular junction. 2. Similar negative results were obtained with dihydro-beta-erythroidine and myanesin. 3. A small liberation of K from perfused muscle does result from treatment with acetylcholine. This is probably due to the contracture of the muscle since the effect is largely eliminated by previous treatment of the muscle with curare. The amount of potassium lost in this way from perfused muscles is too small to detect when muscles are analyzed after immersion in Ringer's solution with and without acetylcholine. It is concluded that there is no significant cation exchange between acetylcholine and K in muscle, but only a small loss of K due to the contracture produced by the acetylcholine.


The reduction of formaldehyde by bacterial cells. Formaldehyde is reduced to methyl alcohol by living cells of a creatinine-decomposing strain of Pseudomonas aeruginosa. The amount of HCHO taken up in 30 minutes by 3 x 10(10) cells of this organism is termed its reducing capacity. It was found to be 400 to 480 microg. The reaction takes place over wide pH and temperature ranges, is independent of the concentration of formaldehyde as long as the latter is not high enough to exert a toxic effect on the cell, but depends on the number of bacteria present. In cultures, 3 to 7 days old, there is a decline in reducing capacity without a proportionate decrease in the number of viable cells. On the other hand in cultures, 2 to 4 weeks old, the number of viable cells determines the amount of HCHO taken up. N/100 NaOH depresses the reducing capacity of the organism without affecting bacterial viability. Exposure of bacterial suspensions to temperatures of 46-52 degrees C. for 10 minutes causes a far more rapid decrease in the number of viable cells than in reducing capacity. Incubation of cellular suspensions with nutrient substances, which are able to support adequately the growth of the organism, for 30 minutes prior to the addition of HCHO, induces increases in reducing capacity. The uptake of HCHO by different microorganisms seems to be related to their gaseous and nutritional requirements. Strains of P. aeruginosa and P. fluorescens are predominantly aerobic, least fastidious in their nutritional requirements, most active against HCHO, and least susceptible to the action of aureomycin and chloromycetin. The potential significance of cellular reducing capacity is discussed.


Enzyme activity and bacteriophage infection. I. Breakdown of adenosinetriphosphate. Experiments have been performed on the apyrase activity of E. coli, strain B. Although the dependence on pH and substrate is similar to that of rat tissue, the bacterial extracts are inhibited by Ca(++) and stimulated by Mg(++). In bacterial extracts the rate of phosphate release decreases in the course of the reaction, possibly owing to product inhibition. With multiple bacteriophage infection, the apyrase activity of the intact cells increased several fold, and the activity of extracts increased about 30 per cent. It is suggested that the changes could be attributed to an increase in the amount of enzyme although other alternatives cannot be precluded at present.


Some effects of 2537 A on green algae and chloroplast preparations. 1. The kinetics of the inactivation of photosynthesis by 2537 A in Chlorella pyrenoidosa and Scenedesmus D(1) indicate that, while the destruction process is largely a first order effect, higher order effects also occur, which become evident at low exposures. In agreement with previous observations, endogenous respiration is insensitive to exposures which inactivate photosynthesis. 2. In Scenedesmus D(1) a solid dose of ultraviolet has no more effect on the photosynthetic apparatus than a dose of equal total duration interrupted by periods of photosynthesis. Nor is any difference noted if the cells are in a different buffer, e.g. 0.05 M KH(2)PO(4), or carbonate-bicarbonate buffer 9. 3. In C. pyrenoidosa, a solid dose and an interrupted dose cause equal effects on photosynthesis when neutral phosphate buffer is used. If the ultraviolet exposure schedules are identical, equal effects are also noted in cells suspended in buffer 9, and in 0.05 M phosphate (pH 6.2). Solid exposures are, however, much more effective than interrupted exposures, when buffer 9 is used. 4. Oxygen evolution (Hill reaction), photosynthesis, and photoreduction in Scenedesmus D(1) are equally sensitive to a given dose of ultraviolet. The mechanism responsible for adaptation to hydrogen metabolism is not more sensitive to ultraviolet than is the photosynthetic mechanism. The O(2)/H(2)/CO(2) reaction in darkness is less sensitive to ultraviolet than any of the above reactions. 5. Glucose oxidation by C. pyrenoidosa, and colony formation in Scenedesmus D(1) are far more sensitive to a given dose of ultraviolet than photosynthesis in these organisms. 6. The photosynthetic apparatus of C. pyrenoidosa is more sensitive to ultraviolet than that of Scenedesmus D(1). 7. The Hill reaction in chloroplast fragments is also inactivated by 2537 A by a first order process. Exposures which inactivate this reaction completely have no effect on polyphenol oxidase, cytochrome oxidase, or catalase in the same chloroplast preparation. 8. After irradiation, the survival of photosynthesis in Scenedesmus D(1) and of the Hill reaction in chloroplast fragments are independent of the light intensity used to measure these processes. 9. No significant changes occur in the ultraviolet absorption of chloroplasts after an exposure to 2537 A, which completely inactivates the Hill reaction.


The effect of varying the intensity and the duration of preexposure upon foveal dark adaptation in the human eye. The course of foveal dark adaptation was studied as a function of the intensity and duration of preexposure. Four intensities (11,300, 5,650, 1,130, and 565 mL.) and four durations (300, 150, 30, and 15 seconds) were used in all combinations of intensity and duration. The threshold-measuring instrument was a monocular Hecht-Shlaer adaptometer and the threshold measurements were recorded in log micromicrolamberts. There were two subjects and each went through the complete series of intensities and durations five times. The five logarithmic values obtained for each threshold were converted into a geometric mean and these means were the data used in the analysis of the results. The chief results were as follows:- 1. For each subject the final steady threshold value was in the region of 7.0 log micromicroL. 2. As the intensity, or duration, or both, were increased the initial foveal dark adaptation threshold rose, the slope of the curve decreased, and the time to reach a final steady threshold value increased. 3. For those values of preexposure intensity and time for which the product, I x t, is a constant it was found that for the two higher intensities and two longer durations and also for the two lower intensities and two shorter durations, the dark adaptation curves were the same. For other values of I x t = C the curves were generally not the same.


Mitochondria in the flight muscles of insects. I. Chemical composition and enzymatic content. 1. The "indirect" thoracic muscles of adult dipterous and hymenopterous insects consist of a unique type of muscle characterized by the presence of numerous spherical, intracytoplasmic bodies termed "sarcosomes." 2. When the muscle is teased or ground, the sarcosomes are liberated as a turbid suspension of bodies ranging from 1 to 4 micro in diameter. A method is described for the isolation of sarcosomes by a simple differential centrifugation. 3. The cytochemical, chemical, and enzymatic properties of sarcosomes were examined for the purpose of appraising their relation to the cytoplasmic bodies of other tissues. 4. Fresh sarcosomes are slowly but selectively stained by the mitochondrial reagents, Janus green B and pinacyanol. Fixed sarcosomes give a positive reaction with Regaud's mitochondrial stain. 5. Chemical analyses show that approximately 29 per cent of the dry weight of sarcosomes consists of lipids and 60 per cent of protein. Microbiological assay indicates the presence of about 1 gamma of riboflavin per milligram of nitrogen. These values resemble those reported for isolated mitochondria of vertebrate liver and kidney. 6. When examined spectroscopically the sarcosomes, like the vertebrate mitochondria, show a high titer of cytochromes a, b, and c. 7. The titer of cytochrome oxidase varies systematically with the adult age of the insect. A similar relation is observed for the enzyme catalase. 8. Isolated sarcosomes show significant titers of succinoxidase, alpha-glycerophosphate dehydrogenase, malic dehydrogenase, and pyruvic dehydrogenase. The following dehydrogenases could not be demonstrated: xanthine, phenylalanine, glycine, lactic, choline, glutamic, and alcohol. These results are compared with those previously reported for vertebrate mitochondria. 9. In view of their manifold points of biochemical similarity, it is concluded that the sarcosomes are the mitochondria of this highly specialized muscular tissue.


Sulfhydryl groups in relation to the metabolism and motility of human spermatozoa. 1. The motility and metabolism of human spermatozoa are inhibited by substances which have an affinity for sulfhydryl groups. 2. These inhibitions can be prevented, and in part, reversed, by the addition to the cell + inhibitor system of sulfhydryl compounds such as cysteine or glutathione. 3. Cysteine and glutathione, under aerobic conditions or in a system in which these substances can be oxidized, show widely different effects on the motility of the spermatozoa. Cysteine destroys the motility of the spermatozoa, whereas glutathione has no effect upon it. 4. Possible mechanisms of these effects are discussed.


Cation exchange in mammalian erythrocytes. III. The prolytic effect of x-rays on human cells. Freshly drawn heparinized human whole blood is exposed to x-rays in amounts up to 54,000 r in vitro and then equilibrated under a controlled atmosphere at 24 or 38 degrees C. For as long as 26 hours following exposure, potassium is progressively lost from the cells and quantitatively replaced by sodium with little, if any, osmotic disturbance. The mean rate of loss at 20,000 r and 24 degrees C. is about 0.4 per cent of the initial cell potassium per hour and approximately doubles for a 20,000 r increase. It is accentuated if blood is stored at low temperature (5 degrees C.) following radiation exposure. Isotope experiments show that the rate of entrance of potassium into the cells is practically unaltered, the principal effect being an acceleration of the rate from cells to plasma. This suggests that radiation may have interfered with a mechanism of selective potassium accumulation based on preferential retention of the element. The sodium which enters the cells following irradiation contributes to the rapidly exchanging portion of the cellular sodium, suggesting that this fraction is ionic sodium.


Growth and phage production of lysogenic B. megatherium. Cell multiplication and phage formation of lysogenic B. megatherium cultures have been determined under various conditions and in various culture media. 1. In general, the more rapid the growth of the culture, the more phage is produced. No conditions or culture media could be found which resulted in phage production without cell growth. 2. Cultures which produce phage grow normally, provided they are shaken. If they are allowed to stand, those which are producing phage undergo lysis. Less phage is produced by these cultures than by the ones which continue to grow. 3. Cells plated from such phage-producing cultures in liquid yeast extract medium grow normally on veal infusion broth agar or tryptose phosphate broth agar, which does not support phage formation, but will not grow on yeast extract agar. 4. Any amino acid except glycine, tyrosine, valine, leucine, and lysine can serve as a nitrogen source. Aspartic acid gives the most rapid cell growth. 5. The ribose nucleic acid content is higher in those cells which produce phage. 6. The organism requires higher concentrations of Mg, Ca, Sr, or Mn to produce phage than for growth. 7. The lysogenic culture can be grown indefinitely in media containing high phosphate concentrations. No phage is produced under these conditions, but the cells produce phage again in a short time after the addition of Mg. The potential ability to produce phage, therefore, is transmitted through cell division. 8. Colonies developed from spores which have been heated to 100 degrees C. for 5 minutes produce phage and hence, infected cells must divide. 9. No phage can be detected after lysis of the cells by lysozyme.


Uptake and retention of fixed carbon in adult mice. 1. Mice were continuously exposed to air containing C(14)O(2). The specific radioactivities of urea carbon, total fecal carbon, and numerous components of tissue carbon were compared as a function of the duration of exposure with the radioactivity of the air CO(2). 2. The data indicate that the total CO(2) fixed from the air is proportional to its concentration in the air. 3. When the CO(2) concentration in the air is normal (0.03 per cent) about 0.34 per cent of the carbon of urea originates from air CO(2). A lesser proportion of the non-urea carbon of urine has its origin from air CO(2). 4. Only about 0.0054 per cent of the total fecal carbon is derived from air when the CO(2) concentration is 0.03 per cent. The constituents, which are extractable with alcohol and water, contain considerably higher proportions of fixed carbon than either the insoluble residue or the ether-extractable material. 5. The rates of uptake at the beginning of the exposure and the rates of loss at the termination of the exposure differed strikingly among the tissues studied. 6. However, the ultimate ratio of fixed air CO(2) carbon to total carbon in these tissues seemed to be approaching limiting values which would not vary by more than a factor of 3 from one another. It appears that of the total organic carbon in an adult mouse approximately 0.01 per cent may originate directly from the CO(2) of the air when the animal respires in air having a CO(2) concentration of 0.03 per cent, and that 1.8 per cent or more of the total carbon may originate from CO(2) within the animal. 7. Data are presented which indicate the life span of the mouse erythrocyte to be 49 days. 8. Calculations made on the basis of these experimental data and the accepted standard for permissible radiation in the human would allow mice to be continuously exposed to air containing 31 microc. per c.m. without ever exceeding the accepted permissible level for humans.


Studies on isolated cell components.

Studies on isolated cell components. 1. The addition of heparin to rat liver, kidney, or brain nuclei has been found to bring about the release of a gel. Chemical analysis and histochemical studies on whole homogenates and isolated nuclei demonstrated that the material released by heparin contained desoxyribonucleic acid (DNA) and protein. The action of heparin on nuclei is interpreted as the result of a combination with the basic proteins of the nucleus with a consequent displacement of DNA. 2. The addition of heparin to a finely divided dilute liver homogenate prepared in a phosphate-sucrose solution at pH 7.1 brings about a marked increase in viscosity which reaches a maximum in 6 to 8 minutes at 23 degrees and then declines. 3. The concentration threshold for the viscosity effect was 0.1 mg. per 100 mg. fresh rat liver, with further increases in viscosity at higher heparin concentrations. Over a period of several hours a marked decrease in response to heparin was observed in homogenates stored at 0 degrees . 4. Fractionation of the homogenate demonstrated that the viscosity increase was due to the presence of the nuclei alone, other components showing no effect. Microscopic observation showed that the increase in viscosity was associated with the appearance of a clear gel around nuclei treated with heparin. 5. Heparin brought about the release of DNA from the nuclei of incubated rat liver, kidney, and brain homogenates. In some instances over half the DNA is found in the supernatant after high speed centrifugation (20 minutes, 21,000 x g). 6. No correlation was found between anticoagulant activity of heparin preparations and their effectiveness in causing an increase in the viscosity of liver homogenates. Desulfated heparin produced none of the results described here for heparin.


A species cross in Cucurbita.

A species cross in Cucurbita.


Marxist genetics at the Stockholm Botanical Congress.


New evidence on the genetics of the Palomino horse.


The "vestigial tail" mouse; a new recessive mutation.


Interspecies hybrids in pines; a summary of interspecific crossings in the genus Pinus made at the Institute of Forest Genetics.


Cytogenetic studies on buckwheat; genetic and cytological studies of compatibility in relation to heterostyly in common buckwheat, Fagopyrum sagittatum.


A goat with heteronymous horns.

A goat with heteronymous horns.


Effects of water source on toxicity of mercurial poisons. I. Standardization of procedure in tests using Allium roots.


Polyembryony in maize and lily; following X-irradiation of the pollen.


John Quincy, M.D. [d. 1722], apothecary and iatrophysical writer: a study of his works, including his commentary on Santorio, his Complete English Dispensatory, and his Lexicon Physico-medicum.


New documents on Volcher Coiter.

New documents on Volcher Coiter.


Tomás Romay and the yellow fever.

Tomás Romay and the yellow fever.


A genetic bud mutation in the pear.

A genetic bud mutation in the pear.


An American doctor in Paris in 1828; selections from the diary of Peter Solomon Townsend, M.D.


Seventeenth century Dutch writers on tropical medicine and tropical herbs.


Field trial of Shigella flexneri III vaccine. VI. Mouse protective studies.


An early prepayment plan for medical care: the Thomsonian system of botanical medicine.


The experimental production of arteritis by passive sensitization.


The serological identification of cultures of Clostridium sporogenes.


A hemolysis inhibition test for the detection of antibodies to Newcastle disease virus.


Effect of X rays upon hemolysin production in the rat.


Studies on the prevention of mumps. I. The determination of susceptibility.


Studies on the prevention of mumps. II. The effect of skin testing upon antibody level and resistance.


Experimental human salmonellosis. II. Immunity studies following experimental illness with Salmonella meleagridis and Salmonella anatum.


The nature of the combining sites of antibodies; the specific protection of the combining site by hapten during iodination.


The effects of cortisone and ACTH on toxins of Rickettsiae and Salmonella typhosa.


Studies on the prevention of mumps. III. The effect of subcutaneous injection of inactivated mumps virus vaccines.


Surgical treatment of hyperthyroidism.

Surgical treatment of hyperthyroidism.


Cardiotoxic action of intravenous procaine.


Are the shoe fitting fluoroscopes a health hazard to the public in Indiana?


Shoulder pinning for neck fractures of humerus.


Studies on the prevention of mumps. IV. The effect of oral spraying of attenuated active virus.


Clinical management of peptic ulcers in general practice.


Malpractice insurance for physicians in the Armed Services.


New linkage groups in the tomato; new data necessitate revision of the fifth, tenth, eleventh and twelfth linkage groups.


A method for analyzing multiple allelic inheritance; in dizygotic twins.


Monoploidy in Nicotiana.

Monoploidy in Nicotiana.


The effect of protein deficiency on the resistance of rats to infection with spirochetes of relapsing fever.


Human carrier of the psittacosis virus.

Human carrier of the psittacosis virus.


Dynamic aspects of the nitrogen metabolism of Plasmodium gallinaceum in vivo and in vitro.


Vitamin requirements of neisseria.

Vitamin requirements of neisseria.


The use of gastric mucin to lower resistance of laboratory animals to systemic fungus infections.


Studies on Plasmodium gallinaceum in vitro. I. A method for maintenance of the erythrocytic parasite in vitro.


Studies on Plasmodium gallinaceum in vitro II. The effects of some 8-aminoquinolines against the erythrocytic parasites.


On the toxic and allergic manifestations caused by the tissues and fluids of Ascaris. III. Hypersensitivity through infection in the guinea pig.


Response of the Syrian hamster to oral administration of modified Newcastle disease virus.


Lysis of Pasteurella pseudotuberculosis by bacteriophage.


A search for poliomyelitis virus in house dust and a study of the effects of drying on the viability of the virus.


The augmentation of the thermogenic effects of pyrogens by homologous plasma in rabbits.


The diagnosis of the menopausal syndrome.


Obesity.

Obesity.


Statement on clinical intoxication from DDT and other new insecticides.


President's address.

President's address.


President-elect's address.

President-elect's address.


Dissecting aneurysm of the aorta.

Dissecting aneurysm of the aorta.


Longevity studies. Length of life and the aged population in Iowa.


Osteoporosis. A review.

Osteoporosis. A review.


Medical education in time of national emergency.


Gynecologic endocrinology in general practice.


Hypertrophic pyloric stenosis. A case report of an infantile type followed by an adult type.


Cardiovascular syphilis.

Cardiovascular syphilis.


CLINICAL pathologic conference; ruptured aneurysm, right middle cerebral artery, with massive subarachnoid and intraventricular bleeding.


A review of 50 operated cases of protruded or ruptured intervertebral discs in the lumbar areas.


The incidence and prognosis in amebiasis.


Sterilizations approved by Iowa's State Board of Eugenics 1949.


Interstitial myocarditis in infancy, report of a case.


STATE University of Iowa College of Medicine clinical pathological conference; subdural empyema (abscess), right cerebral hemisphere, chronic meningitis; and ventriculitis; due to Hemophilus influenza, type B.


Pathology and physiology of headache.

Pathology and physiology of headache.


The relief of mitral stenosis by valvulotomy.


Headache: trigeminal neuralgia.

Headache: trigeminal neuralgia.


Headache diagnosis.

Headache diagnosis.


Medical treatment of headache.

Medical treatment of headache.


Post menopausal bleeding from benign lesions of the genital organs.


Biopsy findings at mitral valvulotomy.

Biopsy findings at mitral valvulotomy.


Diagnosis and prognosis of behavior disorder associated with organic brain disease in children.


Objective determination of the incidence and degree of neuroticism.


Life expectancy in handwriting.

Life expectancy in handwriting.


Trends and opportunities in industrial medicine.


Influence of drugs on the prognosis of cardiovascular disease.


The place of surgery in pulmonary tuberculosis.


The x-ray examination of the spine.

The x-ray examination of the spine.


The experience of a veteran examiner.

The experience of a veteran examiner.


Massive hepatic involvement by metastatic carcinoma with a negative cephalin-cholesterol flocculation reaction. A case report.


The blood pressure as measure for the circulation.


Emotional factors in childhood diseases.


CLINICO-PATHOLOGICAL exercise; intestinal lipodystrophy.


Maine State Police Bureau of Identification.


Ruptured gastric ulcer. An unusual complication following vagotomy and gastroenterostomy.


Peptic ulcer and the pituitary adrenal system.


WALTER S. Milliken, M.D. 1870-1950.

WALTER S. Milliken, M.D. 1870-1950.


Physical medicine and rehabilitation for patients with hemiplegia.


Diagnostic problems in malnutrition.

Diagnostic problems in malnutrition.


A study of Bazetts "K" after acute exercise.


FRANK Elliott Leslie, M.D. 1873-1951.

FRANK Elliott Leslie, M.D. 1873-1951.


What every Maine doctor should know about civil defense and public safety planning; third report.


The importance of voice and speech pathology for insurance medicine.


The evolution of a specialty.

The evolution of a specialty.


The problem of chronic recurrent urticaria and angioedema.


The heart in hypothyroidism.

The heart in hypothyroidism.


Bronchiogenic carcinoma in 12 year old boy.


Ligation of external carotid artery as an expedient in controlling prolonged nasal bleeding.


Abnormal uterine bleeding.

Abnormal uterine bleeding.


Resuscitation of the newborn infant.

Resuscitation of the newborn infant.


Lung abscess.

Lung abscess.


Abdominal actinomycosis with pulmonary involvement. Report of a case.


PEDIATRIC case reports; pulmonary, hepatic, lymph nodes and osseous histoplasmosis.


Health: Alabama's most profitable investment.


CURRENT morbidity statistics, 1951.

CURRENT morbidity statistics, 1951.


MALARIA in Alabama.

MALARIA in Alabama.


The male frog pregnancy test a valuable office procedure.


PROVISIONAL birth and death statistics for December 1950, and comparative rates.


Prefrontal lobotomy.

Prefrontal lobotomy.


Carcinoma of the cervix.

Carcinoma of the cervix.


X-ray therapy; indications and contraindications.


Acute perforated peptic ulcer.

Acute perforated peptic ulcer.


Pediatric case reports.

Pediatric case reports.


ACUTE abdomen.

ACUTE abdomen.


Common geriatric dermatoses.

Common geriatric dermatoses.


Obstruction of the common bile duct by stones.


Allergic myalgia.

Allergic myalgia.


Kala-azar, report of a case and brief review of recent literature.


A review of endometriosis; summary of thirty-two cases at Hurley Hospital.


Congenital paralysis of the inferior oblique.


INTO the second century with the American Medical Association.


Treatment of fractures of the femoral shaft with medullary nail.


Pitfalls in the management of nodular goiter.


Proctology.

Proctology.


CLINICAL pathologic conference; plasmocytoma; Hashimoto's disease.


Two fatal cases of sickle cell anemia.

Two fatal cases of sickle cell anemia.


The primary suture of colostomies.

The primary suture of colostomies.


The mechanism of pulmonary edema from cardiac failure.


The role of edema in clinical gynecology.


Cancer of both breasts, 53 case reports.


Aphasia resulting from cork ball injury of head.


Personal medical disaster insurance.

Personal medical disaster insurance.


Fractures about the ankle.

Fractures about the ankle.


Prevention of suicide.

Prevention of suicide.


Disseminated lupus erythematosus in identical twin sisters associated with diabetes mellitus in one case.


Advances in allergy.

Advances in allergy.


LOWER nephron necrosis; marked postpartum uremia.


Pancreatic islet cell adenoma.

Pancreatic islet cell adenoma.


Illustrations for publication; preparation and reproduction.


A new approach to appliance therapy.

A new approach to appliance therapy.


Some vascular lesions of the lower extremity.


The history of Mercy-Douglass Hospital.

The history of Mercy-Douglass Hospital.


Surgery and the Negro physician: some parallels in background.


The acute abdomen.

The acute abdomen.


Sickle cell anemia in pregnancy. Resumé of literature, with a case report.


Antibacterial agents in surgery.

Antibacterial agents in surgery.


The relationship of chronic cystic mastitis to cancer of the breast.


Pulmonary embolism. A review of twenty-four cases in a five year period at St. Mary's Infirmary.


The endocrinology and physiology of menstruation.


MEDICAL positions open in South Pacific.


Observations on homosexuality among university students.


Part II. Treating migraine by "sleep-rationing".


Self-inflicted dermatoses and their psychodynamics.


The skin: psychodynamic and psychopathologic concepts.


Self-inflicted pre-frontal lobotomy. Report of a case.


A study of unstable personalities after combat.


Cerebral blood flow and metabolism in psychoses of senility.


Location of receptors for tonic neck reflexes.


Origin of cerebellar waves.

Origin of cerebellar waves.


Delayed response performance of monkeys with frontal removals after excitant and sedative drugs.


Cortical projection of vestibular and facial nerves in cat.


Site and extension of bulbar respiratory centre.


Unit activity in bulbar respiratory centre.


Characteristics of responses from electrogenic tissue in Electrophorus electricus.


Resuscitation of the newborn.

Resuscitation of the newborn.


Iron metabolism in pregnancy; the behaviour of haemoglobin, serum iron, the iron-binding capacity of serum proteins, serum copper and free erythrocyte protoporphyrin in normal pregnancy.


Endocrine varieties of "androblastoma" in ovary and testis.


Radiological pelvimetry and the general practitioner.


Chronic endometritis.

Chronic endometritis.


The humoral origin of hypertension in toxaemia of pregnancy.


Prematurity.

Prematurity.


Acute rheumatism in pregnancy.

Acute rheumatism in pregnancy.


Presentation and prolapse of umbilical cord; an analysis of 350 cases.


Venous thrombosis during pregnancy treated with dicoumarin.


Antenatal thrombosis.

Antenatal thrombosis.


A review of 100 cases of transplantation of the ureters in the treatment of obstetrical vesicovaginal fistulae.


Pregnancy and coarctation of the aorta.

Pregnancy and coarctation of the aorta.


A full-time pregnancy in a rudimentary horn of the uterus.


Foetal and placental gas gangrene infection in a case of eclampsia.


Conservative surgery of hydronephrosis. Critical analysis of results obtained by various procedures.


Hyperextension of the head in a breech presentation.


Nephrolithiasis caused by abnormalities of calcium and uric acid metabolism.


Intestinal obstruction.

Intestinal obstruction.


CLINICAL pathologic conference; glioblastoma of cerebellum with recent destructive hemorrhage into left cerebellar hemisphere and subarachnoid space.


Hazards of splenectomy.

Hazards of splenectomy.


Cutaneous manifestations of certain systemic diseases.


Gastro-intestinal function and emotion.

Gastro-intestinal function and emotion.


Methemoglobinemia in infants due to ingestion of nitrates in well water.


Premature infant mortality.

Premature infant mortality.


Success of osteopathy in treatment of epidemic pneumonia and influenza.


Toxemias of pregnancy.

Toxemias of pregnancy.


Pollen hypersensitivity. With brief notes on the possible relationship to penicillin sensitivity.


Studies on the infectious agent of tick-borne fever in sheep.


Circulatory responses to variations in intra-abdominal pressure.


Local production of antibodies.

Local production of antibodies.


The ACRA test as a means of estimating hyaluronidase, deoxyribonuclease and their antibodies.


Staphylococcal phosphatase, glucuronidase and sulphatase.


Identification of Staphylococcus pyogenes by the phosphatase reaction.


Two cases of giant-cell granuloma of the pituitary gland.


Poisoning by P-nitrophenyl diethyl thiophosphate (E. 605); a contribution to the study of anticholinesterase compounds.


The role of some higher peptides in inflammation.


Effects of anterior hypophysis hormones, alone and with some other hormones on ageing female rats.


A method for obtaining accurate and reproducible results in experiments on phagocytosis.


Gross tumour embolism of the axillary artery by malignant synovioma.


Smooth-muscle tumours of the gastrointestinal tract and retroperitoneal tissues presenting as large cystic masses.


Columnar ciliated epithelium in the adult oesophagus.


Gumma of the pancreas in a premature infant.


A new antigen of Brucella abortus.

A new antigen of Brucella abortus.


A cardiac abnormality in the foetus, apparently resulting from premature closure of the foramen ovale due to pressure of a diaphragmatic hernia.


Further observations on the Gram-Twort stain.


The histogenesis of radiation-induced and of benzpyrene induced epidermal tumours in the mouse.


Multiplication of certain Salmonella species in autoclaved buffered tap water.


Preliminary observations on a "dormant" state of sarcoma cells with special reference to resistance to freezing and drying.


Cytoplasmic glycolipids of brain.

Cytoplasmic glycolipids of brain.


The recognition and titration of antibodies to chemical substances by the agglutination reaction.


Tonsillectomy and poliomyelitis.

Tonsillectomy and poliomyelitis.


Juvenile type of Werner's syndrome; progressive musculocutaneous dystrophy observed for eighteen years.


Tonsillectomy and poliomyelitis. II. Frequency of bulbar paralysis, 1944-1949.


Sinobronchitis in infants and children.

Sinobronchitis in infants and children.


The treatment of infantile diarrhea with a new combination of antibiotics.


Congenital tracheo-esophageal fistula without esophageal atresia.


A treatment program for chronic childhood sinobronchitis.


Clinical evaluation of streptomycin in the treatment of bacillary dysentery in infancy and childhood.


The function of a recovery nursery in a large maternity hospital.


The effect of allergy management on growth and development of allergic children.


Type F Hemophilus influenza meningitis; case report with a review of the literature.


Intracranial calcification following pneumococcic meningitis.


Hypereosinophilia with eosinophilic granuloma of the liver associated with ascaris infestation.


Local hemorrhagic-necrotic skin reaction following penicillin; review of literature and case report.


Jejunal polyposis with intussusception and melanin spots.


Mediastinal emphysema pneumothorax, and subcutaneous emphysema complicating kerosene poisoning.


Mother-pediatrician relationship in the neonatal period.


Significant considerations in the prognosis of periodontal disease.


Experimental periodontal reattachment in rhesus monkeys.


Calcified bodies in the gingiva.

Calcified bodies in the gingiva.


An appraisal of developments in periodontology from 1901-50.


Periodontosis in a child resulting in exfoliation of the teeth.


Contribution to the study of the mechanism of action of cholinesterase inhibitors.


The effects of potassium, ammonium, calcium, strontium and magnesium on the electrogram and myogram of mammalian heart muscle.


Relation of gingivitis to dental caries and malocclusion in children 14 to 17 years of age.


The effects of certain compounds on the in vitro synthesis of urea and its precursors.


Some pharmacologic properties of m-tolyloxyacetamidine hydrochloride, a cardiotonic drug.


Studies on the mechanism by which sulfadiazine affects the survival of the mammalian embryo.


The relationship between cholinesterase activity and brain permeability.


Adrenergic blocking action of phenoxy-ethyl analogues of dibenamine.


The effect of 1-hydrazinophthalazine (C-5968) and related compounds on the cardiovascular system of dogs.


The physiological disposition and cardiac effects of procaine amide.


Alkyl nitrites. XIV. The effect of nitrites and nitrates on arterial adenosine triphosphatase.


The action on nicotine-induced tremors of substances effective in Parkinsonism.


Factors influencing fluoroacetate poisoning; practical treatment with glycerol monoacetate.


The effect of topically applied adrenergic blocking agents upon the peripheral vascular system.


Physiological performance following a hypnotic dose of a barbiturate.


Metabolic effects of anesthesia. II. A comparison of acid-base equilibrium in man and in dogs during ether and during cyclopropane anesthesia.


New antibiotics; chloramphenicol, aureomycin, terramycin and neomycin.


The chemistry of antipernicious anemia factors. Part VII. Some transformations of vitamin B12b.


Brazilian jalap. Part II. Further histological and pharmacognostical examination of the four samples of Brazilian jalap and some comparisons with Vera Cruz jalap and Orizaba jalap.


An ultraviolet spectrophotometric quality and stability criterion for medicinal liquid paraffin.


The biological assay of vegetable purgatives. Part III. Cascara and its preparations.


Adsorption studies of two silica gels and a gel-type catalyst.


Sorption hysteresis I. Some factors determining the size of the hysteresis loop.


The solubilization of four typical hydrocarbons in aqueous solution by three typical detergents.


Surface area of porous adsorbents.

Surface area of porous adsorbents.


Micelle shape from dissymmetry measurements.


The effect of salts on the critical concentration, size, and stability of soap micelles.


Ultraviolet absorption spectra of normal cerebrospinal fluid.


Gold number studies, with some observations on sensitization and protection.


The effect of certain reagents upon the properties of bentonite colloids. I. Inorganic salts.


Adsorption curve of a rare earth in an ion-exchange column.


The measurement of low vapor pressures by means of a mass spectrometer.


Measurement of specific surface areas of nonporous powders by a pressure-decline liquid-permeability method.


Cortical secretion of the isolated perfused adrenal.


The pattern of emptying of the human stomach.


The secretory pattern of the stomach of man.


The effect of intra-gastric instillation of a meal on gastric function in man.


Decarboxylation of histidine as a source of error in extracting histamine from tissues.


A comparison of the mixtures of acetic, propionic and butyric acids in the rumen and in the blood leaving the rumen.


Flicker phenomenon in human erythrocytes.


Electrical activity of the cortex accompanying movement.


The origin of the blood fructose of the foetal sheep.


The absorption of acetate, propionate and butyrate from the rumen of sheep.


The absorption of glucose and xylose by adult and newborn rats.


Further study of efferent small-nerve fibers to mammalian muscle spindles; multiple spindle innervation and activity during contraction.


Effects of direct currents on the electrical activity of the spinal cord.


The estimation of chorionic gonadotrophin, using the male British toad Bufo bufo.


Stretch receptor discharges during muscle contraction.


The onset of shortening in striated muscle.


Blood-pressure effects of noradrenaline and adrenaline with special reference to their antagonism by ergotoxine and other blocking agents.


Effects of noradrenaline on coronary flow and heart contraction, as recorded concurrently in the isolated rabbit heart.


Potential changes of the spinal cord following different types of afferent excitation.


The control of the intra-ocular pressure in the rabbit.


The action of myosin-inhibitors on the isolated phrenic nerve diaphragm preparation.


An electronic stimulator of high stability.


An instantaneously recording digital plethysmograph.


Autonomic and somatic activity evoked by stimulation of frontal cortex and thalamus in cats. (Film.).


The American Academy of Restorative Dentistry.


Principles of full denture impression making and their application in practice.


The torus palatinus and its management in full denture construction.


The effect of surface contact in the retention of a denture.


Cleft palate restoration: an interpretation of the Fitz-Gibbon technique.


Relines, rebases, or transfers and repairs.


Alveoloplasty in preparation for the immediate denture insertion.


The role of periodontia in prosthetic dentistry.


Geriatrics and dental service.

Geriatrics and dental service.


Occlusion.

Occlusion.


Practical occlusion in relation to complete dentures.


A study of posterior occlusion in duplicate dentures.


The hinge axis of the mandible.

The hinge axis of the mandible.


The case of the retrusive mandible.

The case of the retrusive mandible.


Specialized frictional attachments and their role in partial denture construction.


Poliomyelitis and army health; a limited review.


A sixteen-day operation in the jungle.

A sixteen-day operation in the jungle.


Some aspects of National Health Service general practice.


Future medical officers for the army.

Future medical officers for the army.


Tick-borne relapsing fever in Somaliland with special reference to the blood sedimentation rate.


The British Army divisional medical organization.


Field training: exercise- hereward.

Field training: exercise- hereward.


MAJOR-GENERAL Cecil Wilmot Mainprise, D.S.O.


The work of St. Dunstan's.

The work of St. Dunstan's.


Chemotherapy in tuberculosis.

Chemotherapy in tuberculosis.


B.A.O.R. medicine 1946-1949.

B.A.O.R. medicine 1946-1949.


Episodes of a general hospital in war.

Episodes of a general hospital in war.


Dr. James Barry.

Dr. James Barry.


SMALLPOX and vaccination.

SMALLPOX and vaccination.


ROYAL Naval Tropical Research Unit.

ROYAL Naval Tropical Research Unit.


Future medical officers for the Army.

Future medical officers for the Army.


Astronavigation.

Astronavigation.


A visit to the West Africa command.

A visit to the West Africa command.


LIEUT.-COLONEL Daniel Litton Harding.

LIEUT.-COLONEL Daniel Litton Harding.


LIEUT.-COLONEL Walter James Waters.

LIEUT.-COLONEL Walter James Waters.


LIEUT.-COLONEL Cuthbert Garrard Browne.

LIEUT.-COLONEL Cuthbert Garrard Browne.


MAJOR-GENERAL Harold John Higgins.

MAJOR-GENERAL Harold John Higgins.


MAJOR-GENERAL Sir Percy Stanley Tomlinson.


LIEUT.-COLONEL Mortimer John Cromie.

LIEUT.-COLONEL Mortimer John Cromie.


On pentabromophenol and pentachlorophenol as molluscacides in the prevention of bilharziasis.


Hydatid cyst in the peritoneum with bilharzial infiltration of its fibrous walls.


A case of chloroma.

A case of chloroma.


Neurological complications of compression fracture of the first lumbar vertebra.


On the validity of Avitellina nagatyi Ezzat, 1945.


The ovulation factor in sterility.

The ovulation factor in sterility.


On the frequency of hydatid disease in Greece and on its treatment.


Combination of solutions of both penicillin and streptomycin for use both in vivo and in vitro.


SHINOUDA Erythroblastosis foetalis.

SHINOUDA Erythroblastosis foetalis.


The treatment and prevention of paradontal disease.


DANIEL Whistler, P.R.C.P. 1683. An early director of Naval Medical Services.


"Maine" chance.

"Maine" chance.


Comparisons of the naval, military, R.A.F. and civil medical services with private practice.


Severe haemorrhage from ulceration Meckel's diverticulum.


A dental cyst.

A dental cyst.


Mal-development of the mandible resulting in gross malocclusion.


Mycotic aneurysm of the sinus of Valsalva in a case of subacute bacterial endocarditis.


Postural drainage.

Postural drainage.


A case of ancylostomiasis.

A case of ancylostomiasis.


SIR G. Lenthal Cheatle, K.C.B., C.V.O., F.R.C.S. 1865-1951.


Modern tendencies in the treatment and prevention of mental illness.


The measurement and survey of atmospheric pollution.


The problem of reduction of atmospheric pollution. Part I. Pollution by sulphur compounds.


The work of a housing manager in the post war era.


The day care of children apart from their parents. Day nurseries.


The social and economic factors influencing the employment of married women.


The problem of reduction of atmospheric pollution. Part II. Elimination of smoke.


The day care of children apart from their parents.


Some factors which influence milk compositional quality.


Some factors affecting the quantity of milk.


Health education as a college entrance unit.


Is the health and physical education program in our schools effective?


REPORT of the committee on terminology in health education.


SUMMER school directory for professional courses in health education.


Social hygiene in the armed forces.

Social hygiene in the armed forces.


San Diego's Family Fair; a project ot promote better families.


Community responsibility in family life.


ABSTRACT of the minutes of the proceedings of the House of Delegates.


World health and treponematoses.

World health and treponematoses.


Does the VD pamphlet educate?

Does the VD pamphlet educate?


The birth models; R. L. Dickinson's monument.


ABSTRACT of minutes of a meeting of the Board of Trustees; Tennessee State Medical Association, April 11, 1951.


VANDERBILT University clinico-pathological conference; congenital polycystic disease of the kidneys.


UNIVERSITY of Tennessee College of Medicine medical staff conference; polycythemia vera.


UNIVERSITY of Tennessee College of Medicine medical staff conference; liver tuberculosis.


Case finding through an understanding of known syphilitic patients.


Syphilis case finding through education.


Syphilis prevalence and community structure.


Disturbance of the pupillary reactions.

Disturbance of the pupillary reactions.


The use of the phonocardiograph in clinical medicine.


Action of ascorbic acid on tuberculin-sensitivity in guinea pigs and its modification by dietary and hormonal factors.


Retropubic prostatectomy: review of 500 cases.


Erythema multiforme exudativum major (Stevens-Johnson syndrome).


Plasmosan. A synthetic substitute for plasma.


Plasmosan in the prevention and treatment of shock.


The first known fatal case of canicola fever.


Coagulability of irradiated plasma.

Coagulability of irradiated plasma.


Deflation of distended bowel at operation.


The anginose type of glandular fever. Report of a case requiring tracheotomy.


Spastic ileus in the presence of mechanical obstruction of small intestine.


Clamps for hysterectomy.

Clamps for hysterectomy.


A new synthetic steroid.

A new synthetic steroid.


The prevention of tuberculosis in young people.


NATIONAL Health Service Tribunal; removal of practitioner's name from list.


INSANITY and intention.

INSANITY and intention.


A mental hospital in British Columbia.

A mental hospital in British Columbia.


PERCIVAL Macleod Yearsley.

PERCIVAL Macleod Yearsley.


Office manners.

Office manners.


Physical exercise; its clinical associations.


Sequelae of radical gastric resections. Clinical and metabolic findings in 35 cases.


GERALDO Horacio de Paula Souza.

GERALDO Horacio de Paula Souza.


Sickle-cell anemia in Greece.

Sickle-cell anemia in Greece.


Fluid mechanics and dynamics of transfusion. Rapid replacement of severe blood loss.


Stenosing tendovaginitis at the radial styloid process. Review of 30 cases.


Prevention and treatment of travel sickness with promethazine chlorotheophyllinate.


"Tennis thumb" tendinitis with calcification in flexor policies longus.


Curettage in the diagnosis of cervical cancer. A modified spoon curette.


Osteomyelitis due to Friedländer's bacillus.


Lethal effect of morphine in chronic cor pulmonale.


Streptomyces fermentation derivatives in acute leukaemia.


Fibrosarcoma of the tongue after interstitial irradiation. Report of a case.


Modified laryngoscope.

Modified laryngoscope.


The Medresco hearing-aid, its use and its value.