Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Chrysoeriol is a flavonoid compound found in several tropical medicinal plants. To elucidate the protective effects of chrysoeriol isolated from Eurya cilliata on the response of osteoblasts to oxidative stress, osteoblastic MC3T3-E1 cells were incubated with chrysoeriol and/or H₂O₂, and markers of osteoblast function and oxidative damage were examined. Chrysoeriol treatment significantly (P < 0.05) reversed the cytotoxic effect of H₂O₂ and increased collagen content, alkaline phosphatase activity and calcium deposition of osteoblasts in the presence of H₂O₂. These effects were blocked by ICI182780, suggesting that chrysoeriol's effect might be partly involved in estrogen action. Moreover, H₂O₂-induced reduction of osteocalcin was recovered in the presence of chrysoeriol. Chrysoeriol significantly (P < 0.05) decreased the production of receptor activator of nuclear factor-κB ligand, interleukin-6, protein carbonyl and malondialdehyde of MC3T3-E1 cells in the presence of H₂O₂. These results demonstrate that chrysoeriol isolated from E. cilliata can protect osteoblasts from oxidative stress-induced toxicity.


Levels of organic and inorganic mercury in human blood predicted from measurements of total mercury. The toxicologically relevant mercury species inorganic and organic Hg in blood are frequently determined by separate measurements of total Hg and of inorganic Hg, with their difference indicating organic Hg. It is shown that the different partition of inorganic and organic Hg between erythrocytes and plasma (e/p ratio) can be used to calculate the concentrations of either Hg species in either blood constituent from measurement of total Hg only. This was tested on the blood of different groups of volunteers. The calculated concentrations of inorganic and organic Hg in cells and plasma were then compared by linear regression with their previously measured counterparts. An accurate prediction has been found for individual levels of inorganic Hg in plasma and organic Hg in cells. These calculated levels were little affected by variations of the e/p ratios. The coincidence between calculated and measured levels of inorganic Hg in cells and organic Hg in plasma was more sensitive to alterations of the e/p ratios. In conclusion, the relevant concentrations of inorganic Hg in plasma and organic Hg in cells can reliably be calculated from measurements of total Hg and from assumed e/p ratios. This means a sizeable reduction of analytical work, and also provides specific information in cases of low-level co-exposure to both Hg species. Besides the possibility to introduce automated analyses of total Hg in mercury speciation in blood, the proposed calculation scheme has the potential to easily enlarge the data base in epidemiological and toxicological surveys of mercury exposure.


Validation of the intact rat weanling uterotrophic assay with notes on the formulation and analysis of the positive control chemical in vehicle. The intact female weanling version in the Organization for Economic Cooperation and Development (OECD) uterotrophic assay Test Guideline (TG) 440 is proposed as an alternative to the adult ovariectomized female version, because it does not involve surgical intervention (vs the ovariectomized version) and detects direct/indirect-acting estrogenic/anti-estrogenic substances (vs the ovariectomized version which detects only direct-acting estrogenic/anti-estrogenic substances binding to the estrogen receptor). This validation study followed OECD TG 440, with six female weanling rats (postnatal day 21) per dose group and six treatment groups. Females were weighed and dosed once daily by oral gavage for three consecutive days, with one of six doses of 17α-ethinyl estradiol in corn oil at 5 ml kg⁻¹ at 0 and 0.1-10 µg kg⁻¹ per day. On postnatal day 24, the juvenile females were euthanized by CO₂ asphyxiation, weighed, livers weighed and uteri weighed wet and blotted. The presence or absence of vaginal patency was recorded. Absolute and relative (to terminal body weight) uterine wet and blotted weights and uterine luminal fluid weights were significantly increased at 3.0 and 10.0 (both P < 0.01) µg kg⁻¹ per day, and increased to ~140% of control values at 1.0 µg kg⁻¹ per day (not statistically significantly). In vivo body weights, weight changes, feed consumption, liver weights and terminal body weights were unaffected. Vaginal patency was not acquired in any female at any dose, although vaginal puckering was observed in one female at 10.0 µg kg⁻¹ per day. Therefore, this intact weanling uterotrophic assay is validated in our laboratory for use under US and European endocrine toxicity testing programs/legislation.


Preliminary evaluation of acute toxicity of (188) Re-BMEDA-liposome in rats. Liposomes can selectively target cancer sites and carry payloads, thereby improving diagnostic and therapeutic effectiveness and reducing toxicity. To evaluate therapeutic strategies, it is essential to use animal models reflecting important safety aspects before clinical application. The objective of this study was to investigate acute radiotoxicity of ¹⁸⁸Re-N,N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine (BMEDA)-labeled pegylated liposomes (¹⁸⁸Re-BMEDA-liposome) in Sprague-Dawley rats. Rats were administered with ¹⁸⁸Re-BMEDA-liposome, normal saline as blank or non-radioactive liposome as vehicle control via intravenous injection and observed for 14 days. Examinations were conducted with respect to mortality, clinical signs, food consumption, body weight and hematological and biochemical analyses. In addition, gross necropsy, histopathological examinations and cytogenetic analyses were also performed. None of the rats died and no clinical sign was observed during the 14-day study period. Rats administered with ¹⁸⁸Re-BMEDA-liposome at dosage of 185 MBq displayed a significant weight loss compared with the control from study day (SD) 1 to SD 4, and the white blood cell count reduced to 5-10% of initial value (female: 18.55 ± 6.58 to 0.73 ± 0.26 x 10³  µl⁻¹; male: 14.52 ± 5.12 to 1.43 ± 0.54 x 10³  µl⁻¹) 7 days-post injection, but were found to have recovered on SD 15. There were no significant differences in biochemical parameters and histopathological assessments between the ¹⁸⁸Re-BMEDA-liposome-treated and control groups. The frequencies of dicentric chromosomes were associated with dosage of ¹⁸⁸Re-BMEDA-liposome. The information generated from this study on acute toxicity will serve as a safety reference for further subacute toxicity study in rats and human clinical trials.


Naturally contaminated shellfish samples: quantification of diarrhetic shellfish poisoning toxins in unhydrolysed and hydrolysed extracts and cytotoxicity assessment. Contamination of shellfish from the Portuguese coast with diarrhetic shellfish poisoning (DSP) toxins is a recurrent event, with most of the commercial bivalves contaminated with high percentages of esters of okadaic acid (OA) and dinophysistoxin-2 (DTX2). This report describes the quantification of DSP toxins in unhydrolysed and hydrolysed extracts of several cockle and mussel samples naturally contaminated and the evaluation of their cytotoxicity profiles in V79 cells. The quantification of the acyl esters in the shellfish samples involved the cleavage of the ester bond through alkaline hydrolysis and the release of the parent toxins OA and DTX2. Unhydrolysed and hydrolysed extracts were then analyzed by liquid chromatography (LC) coupled with mass spectrometry (MS) for the detection and quantification of DSP toxins. The cytotoxicity of the analysed extracts was evaluated using the MTT reduction assay and compared with the cytotoxicity presented by different concentrations of OA standard (1-100 nM). OA exhibited marked cytotoxic effects and decreased cell viability in a dose dependent mode, with an IC₅₀ of 27 nM. The cytotoxicity pattern of unhydrolysed extracts was clearly dependent on the concentration of free toxins. Moreover, the cytotoxicity of the esterified toxins present was revealed after their conversion into free toxins by alkaline hydrolysis. For the hydrolysed extracts of cockles and mussels, the cytotoxicity presented was mainly related to the concentration of OA and DTX2.


Congenital megalourethra: prenatal diagnosis and postnatal/autopsy findings in 10 cases. Congenital megalourethra is a rare urogenital malformation characterized by dilation and elongation of the penile urethra associated with absence or hypoplasia of the corpora spongiosa and cavernosa. Postnatal complications include voiding and erectile dysfunction as well as renal insufficiency and pulmonary hypoplasia. To date, only a few prenatally diagnosed cases have been reported. We report on 10 cases diagnosed prenatally and their postnatal/autopsy findings. The study involved retrospective chart review of all cases diagnosed antenatally in three tertiary care centers over 5 years. Antenatal ultrasound images and medical records from obstetrics, genetics, urology and nephrology were reviewed. Ten fetuses with megalourethra were identified at a median gestational age of 19 (range, 13-24) weeks and all were confirmed postnatally or at autopsy. Three pregnancies were terminated and seven continued. All cases presented with a distended bladder and megalourethra and all cases had normal karyotype. Of seven liveborn babies, one died neonatally of pulmonary hypoplasia. All six infants alive at the time of writing had a dysfunctional urethra and three suffered from impaired or end-stage renal disease. Associated anomalies were found in half of the cases. Congenital megalourethra is caused by abnormal development or hypoplasia of the penile erectile tissue, secondary to distal urethral obstruction. When the amniotic fluid volume is normal, survival is possible. However, all liveborn infants have voiding and renal dysfunction and sexual dysfunction is expected. Megalourethra should be considered in all male fetuses presenting prenatally with megacystis and detailed fetal ultrasonography should look for an elongated and/or distended phallic structure as well as any associated anomalies.


Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors. Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality. Pyridostigmine is the only FDA-approved substance for such use. The AChE-inhibitory activity of known AChE inhibitors was quantified in vitro and their in vivo mortality-reducing efficacy was compared, when given prophylactically before the exposure to the OPC diisopropylfluorophosphate (DFP). The IC50 was measured in vitro for the known AChE inhibitors pyridostigmine, physostigmine, ranitidine, tiapride, tacrine, 7-methoxytacrine, amiloride, metoclopramide, methylene blue and the experimental oxime K-27. Their in vivo efficacy, when given as pretreatment, to protect rats from DFP-induced mortality was quantified by determining the relative risk of death (RR) by Cox analysis, with RR = 1 for animals given only DFP, but no pretreatment. Physostigmine was the strongest in vitro AChE-inhibitor (IC50 = 0.012 µ m), followed by 7-methoxytacrine, tacrine, pyridostigmine and methylene blue. Ranitidine (IC50 = 2.5 µ m), metoclopramide and amiloride were in the mid-range. Tiapride (IC50 = 256 µ m) and K-27 (IC50 = 414 µ m) only weakly inhibited RBC AChE activity. Best in vivo protection from DFP-induced mortality was achieved when physostigmine (RR = 0.02) or tacrine (RR = 0.05) was given before DFP exposure, which was significantly superior to the pretreatment with all other tested compounds, except K-27 (RR = 0.18). The mortality-reducing effect of pyridostigmine, ranitidine and 7-methoxytacrine was inferior, but still significant. Tiapride, methylene blue, metoclopramide and amiloride did not significantly improve DFP-induced mortality. K-27 may be a more efficacious alternative to pyridostigmine, when passage into the brain precludes administration of physostigmine or tacrine.


A simple method for large-scale generation of dopamine neurons from human embryonic stem cells. Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are potentially valuable in drug screening and as a possible source of donor tissue for transplantation in Parkinson's disease. However, existing culture protocols that promote the differentiation of DA neurons from hESCs are complex, involving multiple steps and having unreliable results between cultures. Here we report a simple and highly reproducible culture protocol that induces expandable DA neuron progenitors from hESCs in attached cultures. We found that the hESC-derived neuronal progenitors retain their full capacity to generate DA neurons after repeated passaging in the presence of basic fibroblast growth factor (bFGF) and medium conditioned with PA6 stromal cells. Using immunocytochemistry and RT-PCR, we found that the differentiated DA neurons exhibit a midbrain phenotype and express, e.g., Aldh1a, Ptx3, Nurr1, and Lmx1a. Using HPLC, we monitored their production of DA. We then demonstrated that the expanded progenitors are possible to cryopreserve without loosing the dopaminergic phenotype. With our protocol, we obtained large and homogeneous populations of dopaminergic progenitors and neurons. We conclude that our protocol can be used to generate human DA neurons suitable for the study of disease mechanisms, toxicology, drug screening, and intracerebral transplantation.


Labdane-type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity. In the course of screening plants used in natural medicines as memory enhancers, a 70% ethanol extract of the aerial parts of Leonurus heterophyllus showed significant AChE inhibitory activity. Bioassay-guided fractionation and repeated column chromatography led to the isolation of a new labdane-type diterpenoids (1), named leoheteronin F, and six known compounds (2-7). The chemical structures of isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. The isolates 1-7 were investigated in vitro for their anticholinesterase activity using mouse cortex AChE enzyme. Leoheteronin A (5) and leopersin G (7), which possess a 15,16-epoxy group at the side chain, were found to be potent in the inhibition of AChE.


Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines. Natural occurring compounds are considered an important source of antitumoral agents. In the present study, the cytotoxic potential of three pentacyclic triterpenes isolated from Chuquiraga erinacea (Asteraceae), against the human leukemic cell lines NB4 and K562 was assessed. Heliantriol B2 (HB2) showed the highest cytotoxic activity after 24 h treatment showing IC(50) values of 1.98 ± 0.12 µm and 3.52 ± 0.14 µm for NB4 and K562 cells, respectively. This activity was higher than that of the reference compound dequalinium (DQA). Apoptosis and necrosis induced by HB2 in both NB4 and K562 cell lines were analysed by Annexin V/PI labeling. Mitochondrial alterations including reactive oxygen species (ROS) production and mitochondrial transmembrane potential (ΔΨm) were also tested. The results demonstrated that HB2 induced cell death by apoptosis and necrosis and showed enhanced cytotoxic effects in combination with DQA. Besides, HB2 induced ROS overproduction in NB4 cells and a slight decrease of ΔΨm. Consequently, our findings prompt further studies on the HB2 mechanism of action and its selectivity to tumor cells in order to assess the potential of HB2 as an agent for cancer treatment.


Caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside 1 induced apoptosis through caspase 3-dependent pathway in human hepatoma cell line SMMC7721. Caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside (CDMC), the C-21 steroidal glycoside recently extracted from the traditional Chinese medicinal plant, the root of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae), has been shown to possess potent antitumor properties. However, the bioactivities of CDMC are still largely unknown, especially the antitumor effect and its mechanism. This study investigated the CDMC antitumor effects on human hepatoma cell line SMMC7721 cells by analysis of cell viability, cell cycle phases and apoptosis. The results showed that CDMC inhibited the growth of SMMC7721 cells in a time- and dose-dependent manner and resulted in cell cycle arrest in G(0)/G(1) phase. Furthermore, CDMC induced SMMC7721 cell apoptosis rather than necrosis through caspase 3 activation, and a caspase 3 inhibitor, Ac-DEVD-CHO, could attenuate the apoptosis induced by CDMC. The results suggested that the anticancer activity of CDMC could be attributed partially to its inhibition of cell proliferation and induction of apoptosis associated with caspase 3 activation.


Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. The aim of our study was to examine the therapeutic effect of osthole, an active constituent isolated from the fruit of Cnidium monnieri (L.) Cusson, on alcohol-induced fatty liver in mice and investigate its potential mechanisms of treatment. A mouse alcoholic fatty liver model was established by feeding 52% alcohol for 4 weeks. These experimental mice were then treated with osthole 10, 20 and 40 mg/kg for 6 weeks. The levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and hepatic tissue contents of TC, TG and malondialdehyde (MDA) in osthole-treated groups were significantly decreased, while the level of superoxide dismutase (SOD) was significantly increased compared with the model group. Moreover, the cytochrome P450 (CYP) 2E1 and diacylglycerol acyltransferase (DGAT) mRNA expressions in mouse liver were significantly decreased, and the carnitine palmitoyltransferase (CPT) 1A mRNA expression was increased by osthole treatment. Importantly, the histological evaluation of liver demonstrated that osthole dramatically decreased lipid accumulation. It was concluded that osthole was effective in treating mouse alcoholic fatty liver, and its main mechanisms might be related to reduction of hepatic oxidative stress, including the inhibition of reactive oxygen species (ROS) production, enhancement of antioxidative enzyme activity, and reduction of lipid accumulation and peroxidation.


A matrix solid-phase dispersion-gel permeation chromatography-programmed temperature vaporisation-GC-MS procedure for the analysis of polycyclic aromatic hydrocarbons in mussel samples. A simultaneous matrix solid-phase dispersion extraction-gel permeation chromatography cleanup with programmed temperature vaporisation GC-MS determination is proposed for the analysis of parent and alkylated polycyclic aromatic hydrocarbons (PAHs) in mussel samples. The parameters affecting the extraction and elution efficiency were studied. Final conditions were: 0.5 g of mussel sample, 0.5 g diatomaceous earth as dispersant; and 4 g of Bio-Beads S-X3 for the gel permeation chromatography. Ethyl acetate/hexane (1:1, v/v) was selected for the elimination of the lipid fraction and the elution of PAHs. The detection and quantification limits achieved with this procedure were between 0.01 μg/kg and 0.67 μg/kg and 0.02 μg/kg and 1.93 μg/kg, respectively. The linearity of the method ranged between 5 μg/kg and 1000 μg/kg for most of the studied PAHs. The method was validated by the analysis of mussel tissue reference material (SRM 2977). The repeatability, intermediate precision and accuracy of the method obtained are in excellent agreement with the certified values. The proposed method is simple, precise and robust; no special instruments or costly equipment are required, and a reduction in the total time of analysis, sample handling and solvent consumption is achieved in comparison with classic procedures.


Molecular-imprinted polymer extraction combined with dispersive liquid-liquid micro-extractionfor ultra-preconcentration of mononitrotoluene. Molecular-imprinted polymer (MIP) combined with dispersive liquid-liquid micro-extraction (DLLME) were developed for ultra-preconcentration and determination of mononitrotoluenes in wastewater samples using gas chromatography-flame ionization detector. MIP was synthesized by copolymerization of methacrylic acid-ethylene glycole dimethacrylate-2,2-azobisisobutyronitrile as the initiator that imprinted with 3-nitrotoluene as the template molecule. Effects of several factors, such as type and volume of eluent, adsorption, and desorption times of the analyte on the polymer, and breakthrough volume were investigated. Optimization of 3-nitrotoluene extraction from MIP was studied forward followed by DLLME. Preconcentration factor of MIP-DLLME method was about 2800 under the optimum conditions. The LOD of the proposed method was 0.02 μg/L and a linear dynamic range in the range of 0.04-20 μg/L was obtained. The performance of the present method was evaluated for extraction and determination of nitrotoluene compounds in wastewater samples in the range of microgram per liter and satisfactory results were achieved (RSD<13%).


Absent gallbladder on fetal ultrasound: prenatal findings and postnatal outcome. Fetal gallbladder non-visualization on prenatal ultrasound in the second trimester is uncommon and in most cases the gallbladder is detected eventually. Associations of gallbladder non-visualization with cystic fibrosis, aneuploidy, agenesis of the gallbladder and biliary atresia have been reported. We present our experience and review the literature. During the study period from January 2004 to June 2009 we collected prospectively cases of non-visualization of the fetal gallbladder in the second trimester. In each case the fetus was evaluated by two examiners on at least two occasions, at least a week apart. Cases with no additional sonographic malformations were designated as isolated. Further evaluation included follow-up scans and a meticulous search for fetal anomalies. All patients were offered genetic consultation. Cystic fibrosis testing, amniocentesis for karyotyping and analysis of fetal digestive enzymes in the amniotic fluid were offered. We collected 21 cases of non-visualization of the fetal gallbladder, 16 of which were isolated and five of which had additional malformations. In four of these five, the associated anomalies were severe and the pregnancies were terminated for aneuploidy (two cases of trisomy 18 and one triploidy) or for the severity of the associated anomalies. Associated anomalies included left isomerism with complex cardiac anomaly and intrauterine growth restriction with multisystem anomalies. The fifth fetus had interrupted inferior vena cava with azygos continuation without other anomalies and the child was alive and well at the age of 4 years. In 15 of the 16 isolated cases, antenatal and postnatal development were normal at the last follow-up, ranging from 4 months to 2.5 years. One case of cystic fibrosis was diagnosed prenatally and this pregnancy was terminated. There were no diagnoses of abnormal karyotype or biliary atresia among cases of isolated non-visualization of the gallbladder. When prenatal non-visualization of the fetal gallbladder is associated with other severe malformation, aneuploidy should be suspected. When it is isolated, if cystic fibrosis is ruled out, the outcome is good.


Integration of normal phase liquid chromatography with supercritical fluid chromatography for analysis of fruiting bodies of Ganoderma lucidum. In this study, a comprehensive 2-D chromatography was constructed, consisting of normal phase LC (NPLC) with a CN column as the first dimension, and supercritical fluid chromatography (SFC), with a Merck Chromolith Flash C(18) column as the second dimension, which were connected by a 10-port, dual-position valve controlled automatically by a self-designed software. Such platform was applied into the analysis of the fruiting bodies of Ganoderma lucidum, a traditional Chinese medicine, and within 2 h analysis, the obtained peak capacity of the 2-D-NPLC-SFC system was about 350, obviously higher than that of each dimension. These results demonstrate that 2-D-NPLC-SFC is not only of good orthogonality, but also of high throughput for the analysis of complex samples.


Separation of parent homopolymers from diblock copolymers by liquid chromatography under limiting conditions of desorption 4. Role of eluent and temperature. Liquid chromatography under limiting conditions of desorption (LC LCD) enables fast, base-line discrimination of both parent homopolymers from various diblock copolymers in one single step. The low molecular admixtures are fully separated, as well. General rules are discussed in detail for selection of mobile phases and temperature applied in LC LCD of block copolymers. Typical practical separation examples are presented. It is shown that both the composition of the well-selected LC LCD mobile phase and the temperature of experiment may vary in a broad range without affecting the basics of method. This implies that the method is robust and user friendly.


Commentary on "Secondary use of electronic health record data: spontaneous triggered adverse drug event reporting" by Linder et al.


A graph-based algorithm for mining multi-level patterns in genomic data. Comparative genomics is concerned with the study of genome structure and function of different species. It can provide useful information for the derivation of evolutionary and functional relationships between genomes. Previous work on genome comparison focuses mainly on comparing the entire genomes for visualization without further analysis. As many interesting patterns may exist between genomes and may lead to the discovering of functional gene segments (groups of genes), we propose an algorithm called Multi-Level Genome Comparison Algorithm (MGC) that can be used to facilitate the analysis of genomes at multi-levels during the comparison process to discover sequential and regional consistency in gene segments. Different genomes may have common sub-sequences that differ from each other due to mutations, lateral gene transfers, gene rearrangements, etc., and these sub-sequences are usually not easily identified. Not all the genes can have a perfect one-to-one matching with each other. It is quite possible for one-to-many or many-to-many ambiguous relationships to exist between them. To perform the tasks effectively, MGC takes such ambiguity into consideration during genome comparison by representing genomes in a graph and then make use of a graph mining algorithm called the Multi-Level Attributed Graph Mining Algorithm (MAGMA) to build a hierarchical multi-level graph structure to facilitate genome comparison. To determine the effectiveness of these proposed algorithms, experiments were performed using intra- and inter-species of Microbial genomes. The results show that the proposed algorithms are able to discover multiple level matching patterns that show the similarities and dissimilarities among different genomes, in addition to confirming the specific role of the genes in the genomes.


Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS. Direct analysis in real time (DART) ion source is a powerful ionising technique for the quick and easy detection of various organic molecules without any sample preparation steps, but the lack of quantitation capacity limits its extensive use in the field of phytochemical analysis. To improvise a new system which utilize DART-MS as a hyphenated detector for quantitation. A total extract of Schisandra chinensis fruit was analyzed on a TLC plate and three major lignan compounds were quantitated by three different methods of UV densitometry, TLC-DART-MS and HPLC-UV to compare the efficiency of each method. To introduce the TLC plate into the DART ion source at a constant velocity, a syringe pump was employed. The DART-MS total ion current chromatogram was recorded for the entire TLC plate. The concentration of each lignan compound was calculated from the calibration curve established with standard compound. Gomisin A, gomisin N and schisandrin were well separated on a silica-coated TLC plate and the specific ion current chromatograms were successfully acquired from the TLC-DART-MS system. The TLC-DART-MS system for the quantitation of natural products showed better linearity and specificity than TLC densitometry, and consumed less time and solvent than conventional HPLC method. A hyphenated system for the quantitation of phytochemicals from crude herbal drugs was successfully established. This system was shown to have a powerful analytical capacity for the prompt and efficient quantitation of natural products from crude drugs.


Relative von Neumann entropy for evaluating amino acid conservation. The Shannon entropy is a common way of measuring conservation of sites in multiple sequence alignments, and has also been extended with the relative Shannon entropy to account for background frequencies. The von Neumann entropy is another extension of the Shannon entropy, adapted from quantum mechanics in order to account for amino acid similarities. However, there is yet no relative von Neumann entropy defined for sequence analysis. We introduce a new definition of the von Neumann entropy for use in sequence analysis, which we found to perform better than the previous definition. We also introduce the relative von Neumann entropy and a way of parametrizing this in order to obtain the Shannon entropy, the relative Shannon entropy and the von Neumann entropy at special parameter values. We performed an exhaustive search of this parameter space and found better predictions of catalytic sites compared to any of the previously used entropies.


FuzzyART neural network for protein classification. One of the major research directions in bioinformatics is that of predicting the protein superfamily in large databases and classifying a given set of protein domains into superfamilies. The classification reflects the structural, evolutionary and functional relatedness. These relationships are embodied in hierarchical classification such as Structural Classification of Protein (SCOP), which is manually curated. Such classification is essential for the structural and functional analysis of proteins. Yet, a large number of proteins remain unclassified. We have proposed an unsupervised machine-learning FuzzyART neural network algorithm to classify a given set of proteins into SCOP superfamilies. The proposed method is fast learning and uses an atypical non-linear pattern recognition technique. In this approach, we have constructed a similarity matrix from p-values of BLAST all-against-all, trained the network with FuzzyART unsupervised learning algorithm using the similarity matrix as input vectors and finally the trained network offers SCOP superfamily level classification. In this experiment, we have evaluated the performance of our method with existing techniques on six different datasets. We have shown that the trained network is able to classify a given similarity matrix of a set of sequences into SCOP superfamilies at high classification accuracy.


Computational gene knockout reveals transdisease-transgene association structure. Genome-wide association studies for a variety of diseases are identifying increasing numbers of candidate genes. Now we are confronted with the fact that some genes are common candidates across diseases. Thus there is a strong need to develop a hypothesis formulation methodology to comprehend multifaceted associations between genes and diseases. We have developed a computational method for building transdisease-transgene association structure. By introducing the basic rationale underlying the gene knockout approach as an information processing procedure to a network constructed on the basis of hyperlinks between disease and gene pages listed in the Online Mendelian Inheritance in Man (OMIM) database, relations of genes with diseases are computationally quantified. We did successively eliminate gene pages (called "computational gene knockout" in this paper) expected to contribute to metabolic syndrome, and catalogued each association with various disease pages. We thereby apply a co-clustering method to the gene-disease relations to obtain an association structure by classifying diseases and genes simultaneously. Observing an association structure between over 100 diseases and their related genes, we then found that the structure revealed gene classes that were commonly associated with diseases as well as gene classes that were selectively associated with a specific disease class.


Protein secondary structure prediction using NMR chemical shift data. Accurate determination of protein secondary structure from the chemical shift information is a key step for NMR tertiary structure determination. Relatively few work has been done on this subject. There needs to be a systematic investigation of algorithms that are (a) robust for large datasets; (b) easily extendable to (the dynamic) new databases; and (c) approaching to the limit of accuracy. We introduce new approaches using k-nearest neighbor algorithm to do the basic prediction and use the BCJR algorithm to smooth the predictions and combine different predictions from chemical shifts and based on sequence information only. Our new system, SUCCES, improves the accuracy of all existing methods on a large dataset of 805 proteins (at 86% Q(3) accuracy and at 92.6% accuracy when the boundary residues are ignored), and it is easily extendable to any new dataset without requiring any new training. The software is publicly available at http://monod.uwaterloo.ca/nmr/succes.


Analysis of qPCR data by converting exponentially related Ct values into linearly related X0 values. A common method for calculating results from qPCR experiments is the comparative Ct method, also called the 2(-ΔΔCt) method. However, several assumptions are included in the 2(-ΔΔCt) method and standard statistical analyses are not directly applicable. Here, we describe a different method, the X(0) method, for result calculations and statistical analysis from qPCR experiments. The X(0) method differs from the 2(-ΔΔCt) method by introducing a conversion of the exponentially related Ct values into linearly related X(0) values, which represent the amount of starting material in a qPCR experiment. Results calculated by the X(0) method are illustrated for qPCR experiments with technical and biological replicates, including procedures to calculate standard deviations. Incorporation of primer efficiencies in calculations by the X(0) method is also described. Altogether, the X(0) method constitutes a very simple and accurate alternative to the 2(-ΔΔCt) method for result calculations from qPCR data.


Improving the inter-corpora compatibility for protein annotations. Although there are several corpora with protein annotation, incompatibility between the annotations in different corpora remains a problem that hinders the progress of automatic recognition of protein names in biomedical literature. Here, we report on our efforts to find a solution to the incompatibility issue, and to improve the compatibility between two representative protein-annotated corpora: the GENIA corpus and the GENETAG corpus. In a comparative study, we improve our insight into the two corpora, and a series of experimental results show that most of the incompatibility can be removed.


A re-evaluation of biomedical named entity-term relations. Text mining can support the interpretation of the enormous quantity of textual data produced in biomedical field. Recent developments in biomedical text mining include advances in the reliability of the recognition of named entities (NEs) such as specific genes and proteins, as well as movement toward richer representations of the associations of NEs. We argue that this shift in representation should be accompanied by the adoption of a more detailed model of the relations holding between NEs and other relevant domain terms. As a step toward this goal, we study NE-term relations with the aim of defining a detailed, broadly applicable set of relation types based on accepted domain standard concepts for use in corpus annotation and domain information extraction approaches.


Observations upon the form and relations of the maternal and fetal vessels in the placenta of the sheep.


Placentation and angiogenesis in the amnion of a baboon (Papio papio).


The development and histology of pituitary concretions in man.


Scent glands of the short-tailed shrew.

Scent glands of the short-tailed shrew.


Response to pituitary growth hormone and thyroxin of the tibias of hypophysectomized rats after long postoperative intervals.


Changes in the blood of the dog with age.


Visual factors in the design of military aircraft.


Bilateral superior vena cavae.

Bilateral superior vena cavae.


The effect of ammonium chloride on altitude tolerance.


Thermocouples and the measurement of body temperatures in the laboratory and in flight.


Selection of men for aeronautical training based on susceptibility to motion sickness.


Physical exertion in the heat: some notes on its physiology and hygiene.


The effects of hypocapnia on performance.


A method for the continuous analysis of alveolar air.


The high altitude training program for fighter pilots.


Diseases and defects in aircrew trainees; gastro-intestinal system, genito-urinary system.


Recent advances in airplane spraying of DDT for insect control.


The covariance analysis of multiple classification tables with unequal subclass numbers.


Statistical methods in cereal chemistry.


Incomplete-block design adapted to paired tests of mosquito repellents.


Effect of experimental malaria on the electrophoretic pattern of the serum proteins of normal young men.


Relation of fasting ketosis to the protein of the preceding diet.


Studies on the metabolism of 2-acetylaminofluorene in rats.


Central nervous system effects of anticholinergic agents.


The application of a graded type of response technique for the bio-assay of pituitary extract (posterior lobe).


The action of fumariaceous alkaloids.

The action of fumariaceous alkaloids.


Concentration technique for detection of trophozoites of human malaria.


The pharmacology of a new series of choline salts.


The effect of methyl xanthines on urea excretion in rabbits.


The blood pressure lowering effect of local anesthetics used for injection.


Liver injury and its influence upon the acetylcholine splitting activity of rat and dog.


Use of the latent period in studies on the agent of chicken tumor I.


Pharmacology of fluoroacetate.

Pharmacology of fluoroacetate.


Electrocardiographic changes of rats, dogs and monkeys receiving toxic doses of plasmochin and the acid-labile phosphate content of the rat's myocardium.


The effects of di-isopropyl fluorophosphate upon normal subjects and patients with myasthenia gravis.


Comparison of a chemical and a biological method for the assay of a purified digitalis preparation.


Failure of o- or p-mononitrophenol to produce cataract.


The effects of body-gassing with mustard vapor on the carbohydrate metabolism of dogs.


A comparison of the effects of streptomycin on the nutrition of the rat and the mouse.


Pamaquin; occurrence of hemolytic anemias.


The analgesic action of the racemates of I-amino-I-phthalidylpropane hydrochloride.


The diuretic-antidiuretic actions of posterior pituitary and sodium chloride.


Studies on the anticonvulsant properties of diphenylhydantoin.


Loss of potency of commercial insulin stored at room temperature.


Effects of senecionine on the hamster and monkey.


Electrocardiographic changes in pericarditis associated with uremia.


Paroxysmal ventricular tachycardia.

Paroxysmal ventricular tachycardia.


Electrocardiographic studies during and after pneumococcus pneumonia.


Calcification of the mitral valve.

Calcification of the mitral valve.


The peripheral blood flow and rectal and skin temperatures in hypertension.


Studies on the pathogenesis of pulmonary edema following bilateral vagotomy.


An evaluation of the use of multiple versus single precordial leads, in conjunction with the three limb leads, for practical clinical electrocardiography.


Abnormal electrocardiogram following recovery from paroxysmal tachycardia.


Subacute bacterial endocarditis successfully treated with penicillin; report of a case.


Ranula.

Ranula.


The maxillary labial fraenum in the school health service.


Trilene auto analgesia in dentistry.

Trilene auto analgesia in dentistry.


The production of dental alloys and substitutes for plaster of Paris in Changi P.O.W. Camp, Singapore.


Observations on the oral condition of Indian soldiers.


The fluorine-dental caries relationship in general with particular association with Colorado Springs.


The use of x-ray in the diagnosis of systemic disease.


Some legal aspects of the ownership of roentgenograms.


The effect of malnutrition on calcification and growth of the teeth during childhood.


Comparison of thermal and hygroscopic casting technics.


Go modern with preventive dentistry.

Go modern with preventive dentistry.


The problem of the upper partial denture.


Acrylic resin jacket crown construction.


Radiographs in dentistry for children.

Radiographs in dentistry for children.


Immediate denture construction.

Immediate denture construction.


Pulpotomy technic.

Pulpotomy technic.


IMMEDIATE dentures.

IMMEDIATE dentures.


The dentist looks at cancer of the lip.

The dentist looks at cancer of the lip.


The comparative effect of human chorionic and equine gonadotrophins on the rate of ovarian growth.


The influence of estrogens on the crystal structure of bone as revealed by x-ray diffraction studies on the femora of mice.


Tolerance of normal, of thyroidectomized, and of thiourea or thiouracil treated dogs to oral desiccated thyroid and to intravenous thyroxine.


The effects of alloxan diabetes on the in-vitro oxidation of substrates by rat tissues.


The passage of endogenous estrogen across the parabiotic union in rats.


Acid-base equilibrium in relation to the menstrual cycle.


A note on the absence of androgen from a diet of natural foods.


Enterohepatic circulation of oestrogens.


Some factors affecting the absorption rate of subcutaneously implanted hormone tablets.


Some factors affecting absorption from implanted tablets.


Logistic dose-response curves: a theoretical approach.


Functional relation between the uterus and the corpus luteum.


Fertilization of eggs in hypophysectomized rats.


Further observations on the formation of "ghosts" in subcutaneously implanted tablets.


Relation between iodine content and biological activity of thyroid preparations.


Gonad stimulation by androgens in hypophysectomized pigeons.


New Zealand blood-type distributions: preliminary investigations.


Genetic theories of Rh blood types.

Genetic theories of Rh blood types.


The inheritance of allelomorphs of the Rh gene in 50 families.


Filial and fraternal correlations in successive generations.


A further note on the sib-pair linkage method.


Crossing-over in a pedigree containing haemophilic and colour-blind individuals.


The trend of national intelligence.

The trend of national intelligence.


An investigation of 171 possible linkage relationships in man.


Some problems of reproductive physiology.


Positive eugenics; a proposal.

Positive eugenics; a proposal.


An investigation into assortative mating.


Courtship and mating in an urban community.


Birth-rate in Holland.

Birth-rate in Holland.


The control of infection in obstetrics.

The control of infection in obstetrics.


The value of antenatal radiological pelvimetry.


Combined anterior pituitary necrosis and bilateral cortical necrosis of the kidneys, following concealed accidental haemorrhage.


Infertility in women.

Infertility in women.


Male infertility.

Male infertility.


Acute renal failure complicating abortion.


The mother in industry.

The mother in industry.


A case of aplastic anaemia in pregnancy.


A home-made repositor for chronic inversion of the uterus.


Anesthesia for eye, ear, nose and throat surgery.


The place of nitrous oxide-oxygen anesthesia in present day practice of anesthesiology.


Pentothal sodium.

Pentothal sodium.


The use of cyclopropane.

The use of cyclopropane.


Spinal anesthesia from the patient's viewpoint.


Homoeopathy and leg ulcers.

Homoeopathy and leg ulcers.


The syphilitic remedies.

The syphilitic remedies.


A proving of Crocus sativus.

A proving of Crocus sativus.


Tuberculinum; some clinical experiences.


Sketches of surgical-homeopathic experiences.


Homeopathy; the true art of healing.

Homeopathy; the true art of healing.


Homoeopathic therapy in some nerve diseases; tabes dorsalis.


WHAT can a mental hospital do to improve public relations?


What type of hospital for the mental patient?


Metabolites of 2,4,6-trinitrotoluene (TNT) excreted in the urine of dogs.


Summary of twenty-two trinitrotoluene fatalities in World War II.


An experimental evaluation of methionine in the therapy of liver injury from carbon tetrachloride.


Eight cases of methyl chloride poisoning with three deaths.


Evaluation of urinary lead excretion for persons at work.


Dust control in hematite mining; the effect of wet methods.


Dust control in hematite mining; the effect of ventilation.


Application of military mental hygiene to industry.


A program of malarial surveillance for the industrial physician.


Filter paper collection of cadmium and iron fumes in air.


Aplastic anemia following exposure to trinitrotoluene; report of three cases.


A method for the evaluation of protective ointments.


A clinical test for effort tolerance.

A clinical test for effort tolerance.


An outbreak of scabies in stenographers.


Contact dermatitis due to DDT; report of a case.


Arsine poisoning; report of a case.

Arsine poisoning; report of a case.


Medical research in physical education; some physiological limitations of athletic performances.


The use (for cosmetic and biological reasons) of plasmathromboplastin adhesion as a substitute for sutures in thyroid surgery.


Ascaris-pneumonia; notes on the review on Ascaris lumbricoides.


Activation of an originally negative intracutaneous Leishmania-vaccine reaction.


Intramuscular pressure; a critical review.


Pulmonic lesions with eosinophilia.

Pulmonic lesions with eosinophilia.


Filariasis in Bundelkhand.

Filariasis in Bundelkhand.


Teratoma of testis.

Teratoma of testis.


Nervous complications of diphtheria.

Nervous complications of diphtheria.


Infantile hepatic cirrhosis (conditions described as infantile biliary cirrhosis; sub-acute toxic cirrhosis; and infantile liver).


Auto-intoxication.

Auto-intoxication.


A case of maggots in the nasal cavity.

A case of maggots in the nasal cavity.


Ascariasis.

Ascariasis.


Penicillin in chronic arthritis knee.

Penicillin in chronic arthritis knee.


Stanno sulphazide and chaulmoogra oil in chronic skin ulcerations.


Results in the treatment of subacute bacterial endocarditis.


Studies on hypertension; effect of lowering the blood pressures of hypertensive patients by high spinal anesthesia on the renal function as measured by inulin and diodrast clearances.


A roentgen ray and clinical study of primary tuberculosis; Vollmer patch test made on 460 patients; positive reactions secured in 115.


Electrocardiogram in toxemias of pregnancy.


Prothrombin level of peripheral blood and sternal marrow.


Syphilis; a review of the recent literature.


Weil's disease occurrence among workers in Welsh and Scottish coal-mines.


Economic status and the haemoglobin level of children of men in the fighting services and of civilians.


Insulin shock treatment of bronchial asthma.


Carcinoma of the lip and its treatment by radium (1928-1944).


Pyloric stenosis: selective medical and surgical treatment; 50 successive cases without a death or failed medical treatment.


Diphtheritic encephalomyelitis.

Diphtheritic encephalomyelitis.


A case of dysphagia in a woman 78 cured by tonsillectomy.


Iritis in the rheumatic affections.

Iritis in the rheumatic affections.


Prevention of transfusion reactions due to Rh factors.


MEDICAL evidence in pension claims.

MEDICAL evidence in pension claims.


HEALTH Service Bill.

HEALTH Service Bill.


The importance to the medical practitioner of a knowledge of heredity in diseases.


Atabrine studies in the field; the relation of serum atabrine level to breakthrough of previously contracted vivax malaria.


Studies on convalescence; nitrogen and mitral balances during starvation and graduated feeding in healthy young males at bed rest.


Studies on the pharmacology of DDT (2,2 bis-para-chlorophenyl-l,l,l,trichloroethane); the chronic toxicity of DDT in the dog.


Biochemical changes associated with the activity of the adrenal cortex.


Experiences in the psychotherapy of obsessive-schizophrenic personalities.


Pituitary-adrenal cortical control of normal and immune globulin release from lymphocytes.


Laboratory aids in anemia.

Laboratory aids in anemia.


Factors common to surgical lesions of the biliary tract.


The surgical treatment of acute cholecystitis.


Treatment of chronic cholecystitis, with and without stone; indications and contraindications for choledochostomy.


The repair of strictures of the common and hepatic bile ducts.


The treatment of seasonal and non-seasonal hyperesthetic rhinitis with anthallan.


Primary carcinoma of the lung, including a clinico pathologic report of 45 cases at the University Hospital from 1934 to 1946.


The patient's part in reconstructive surgery.


Curare in anesthesia.

Curare in anesthesia.


OBSTETRIC case report.

OBSTETRIC case report.


A brief history of roentgenology in Baltimore.


Some physiologic aspects of the gall bladder.


Facial and body prosthesis.

Facial and body prosthesis.


Influence of posture and exercise on water balance in the normal male.


The pharmacology of a new series of choline salts.


The effect of commercial growth complex upon the oral structures of normal rats.


The doctor goes to court.

The doctor goes to court.


Sulphabenzide in the treatment of intestinal disorders.


Studies in malaria transmission.

Studies in malaria transmission.


Genito-urinary calculi.

Genito-urinary calculi.


Visceroptosis.

Visceroptosis.


The ocular manifestations of cerebral pathology.


The association of nasal sinusitis and a raised blood-pressure.


Newer concepts of peptic ulcer.

Newer concepts of peptic ulcer.


The art of seeing.

The art of seeing.


Lathyrism in the Central Provinces.

Lathyrism in the Central Provinces.


Blood uric acid and chloride in thirty cases of pneumonia.


Pyrogenic reaction.

Pyrogenic reaction.


War-neurosis and psychotherapy.

War-neurosis and psychotherapy.


An outline of health services for the Poona District.


Penicillin in a case of progressive ascending paralysis of Landry's type.


Cibazol in bacillary dysentery.

Cibazol in bacillary dysentery.


Sulphonamide anuria.

Sulphonamide anuria.


Arteriosclerotic diseases.

Arteriosclerotic diseases.


Penicillin; some general considerations regarding its uses.


Prevention of small-pox.

Prevention of small-pox.


Vitamins in general practice.

Vitamins in general practice.


EVOLUTION of medical psychology and the duty before us.


Surgery of the thyroid.

Surgery of the thyroid.


Children's obsessions.

Children's obsessions.


Experimental shock; the relation of metabolic derangements of liver and kidney to vascular reactions.


Biology in wartime.

Biology in wartime.


Sterility in women.

Sterility in women.


Some anatomical factors affecting the stabilising functions of muscles.


Peduncular broncho-pneumonia.

Peduncular broncho-pneumonia.


Post-arsphenamine jaundice; experience in a military hospital.


The relation of research to the practice of medicine.


Hypoproteinemia in surgical patients.

Hypoproteinemia in surgical patients.


Spontaneous hematoma of the rectus muscle in pregnancy.


BRONCHOGENIC carcinoma of the apical portion of the right lung, with widespread metastases.


Caseous tuberculosis of the adrenals with sarcoidosis of other viscera.


BRUCELLOSIS in Iowa; duration of illness.


Medical care for the veteran.

Medical care for the veteran.


Social security and pending legislation affecting it.


The doctor in this new day.

The doctor in this new day.


The roentgenologic diagnosis of abdominal abscesses.


Our new attack on tuberculosis.

Our new attack on tuberculosis.


Highlights and problems related to medical care of veterans.


Dermatitis resulting from exposure to DDT; a preliminary report.


Endocrine problems in gynecology.

Endocrine problems in gynecology.


Some uses of nembutal in obstetrics.

Some uses of nembutal in obstetrics.


When is gonorrhea cured?

When is gonorrhea cured?


Prophylaxis in geriatrics.

Prophylaxis in geriatrics.


Periarteritis nodosa with case report.

Periarteritis nodosa with case report.


The doctor on the witness stand.

The doctor on the witness stand.


Acute appendicitis with complications.

Acute appendicitis with complications.


Chronic disease of the breast.

Chronic disease of the breast.


Helpful considerations in diagnosis of surgical cases of jaundice.


Disabilities of the foot.

Disabilities of the foot.


Rapid chemical disinfection of clean unwashed skin.


Blood-transfusion in Indian famine.

Blood-transfusion in Indian famine.


Leukaemia treated with urethane, compared with deep x-ray therapy.


Serum phosphatase in lathyrism.

Serum phosphatase in lathyrism.


NATIONAL Health Service Bill.

NATIONAL Health Service Bill.


OVERDOSE of moryl.

OVERDOSE of moryl.


Rapid death following injection of antitetanic serum.


Fowler's position.

Fowler's position.


Paralysis agitans.

Paralysis agitans.


Orthopaedic and rehabilitation service of the Royal Air Force.


Lipodystrophy and hepatomegaly, with diabetes, lipaemia, and other metabolic disturbances; a case throwing new light on the action of insulin.


Aminothiazole in the treatment of thyrotoxicosis.


Nutritional neuropathy in prisoners-of-war and internees from Hong-Kong.


Tolerance to octyl nitrite in achalasia of the cardia.


PRACTITIONER'S income.

PRACTITIONER'S income.


Penicillin in subacute bacterial endocarditis.


REMUNERATION of the general practitioner.


The secular trend in the stillbirth-rate.


Importance of student research in the medical schools.


Ideals of pedagogy in their application to medicine.


Intravenous anaesthesia.

Intravenous anaesthesia.


Concerning the treatment of inoperable malignant disease in general practice.


Common infections of the skin.

Common infections of the skin.


The role of surgery in the treatment of bleeding peptic ulcer.


The use of penicillin in infections of the ear, nose and the throat.


Therapy in the treatment of congenital duodonal atresia.


Medicine and the common man.

Medicine and the common man.


Health bills pending in Congress.

Health bills pending in Congress.


Osseous syphilis; report of a case.

Osseous syphilis; report of a case.


Generalized dermatitis from pediculosis capitis.


Hepatoma, with metastases; clinicopathological exercises.


Metastases of carcinoma of cervix; clinicopathological exercises.


Penetrating wounds of the abdomen.

Penetrating wounds of the abdomen.


How to prevent death from breast cancer.


Unusual types of appendicitis.

Unusual types of appendicitis.


Injuries of the elbow in children.

Injuries of the elbow in children.


Orthopedic interest in a fracture.

Orthopedic interest in a fracture.


The symptomatology of uterine retrodisplacements.


Posterior sclerotomy and lens extraction in acute glaucoma secondary to senile cataract.


Estrogenic therapy in diabetes.

Estrogenic therapy in diabetes.


Granuloma coccidioídico.

Granuloma coccidioídico.


A test for bile.

A test for bile.


Bladder injury at cesarean section; a case report.


Sulfonamide susceptibility of stock strains of dysentery bacilli and of strains from recent epidemics.


Comparative study of hypertensinase and proteinase activity of blood plasma.


A study of Rettger's bacillus and related bacteria.


Relative efficiency of the proteins in polished rice and in enriched wheat flour.


Potentiating and pressor action of some N-substituted hexylamines.


Serological reactions of levans formed from sucrose and raffinose by certain bacilli.


Protective action of certain compounds against dietary hepatic damage in the rat.


Experiments with protoporphyrin.

Experiments with protoporphyrin.


Early changes induced in purkinje cells of rabbit by single massive doses of roentgen rays.


Time course of changes in sensory cells of trigeminal ganglion of the rabbit following irradiation.


Bone growth in paralyzed limbs.

Bone growth in paralyzed limbs.


Metabolism of nicotinamide, nicotinic acid and diethylamide of nicotinic acid (coramine) by newborn and premature infants.


Serial transmission of the milk agent of mouse mammary carcinoma.


Biosynthesis of nicotinamide in man.

Biosynthesis of nicotinamide in man.


Vitamin E levels in maternal and fetal blood plasma.


Functional and fatty changes in liver during chronic vitamin B complex deficiency.


Role played by leucocytes, platelets and plasma trypsin in peptone shock in the dog.


Heredity of Rh blood types; improved nomenclature; additional family studies with special reference to Hr.


Pathogenesis of erythroblastosis fetalis.


Antibiotic activity of extract of western red cedar heartwood.


Immunological studies of dengue fever and Colorado tick fever.


A hemorrhagic syndrome induced by derivatives of 3-hydroxy-1,4-naphthoquinone.


Chemotherapy of experimental leishmaniasis.


Electrocardiographic changes in hemorrhage and ischemic compression shock.


Effects of inflammation (turpentine abscess) on iron absorption.


Respiration of heart muscle slices from rats in the terminal stage of hemorrhagic shock.


Thiamin deficiency and susceptibility of rats and mice to infection with Salmonella typhi murium.


Rh antigen and hapten; nature of antigen and its isolation from erythrocyte stroma.


Portal vein ligation and the Eck fistula in the rat.


Number of Peyer's patches in mice belonging to high and low mammary tumor strains.


A quantitative method for the study of chromatolysis.


Removal of bone marrow in living animals.


Perosis caused by feeding high levels of thiouracil.


Serum precipitation reaction in rheumatic fever and in other conditions.


The antagonistic action of choline and its triethyl analogue.


Anticoagulant activity of the trypsin inhibitor from soya bean flour.


Protective effects of glutathione and cysteine against alloxan diabetes in the rat.


Pre-sanatorium.

Pre-sanatorium.


Congenital aniridia.

Congenital aniridia.


The role of the anesthesiologist in the prevention and treatment of thrombophlebitis.


The surgical management of gastric and duodenal ulcers.


Extrapleural pneumothorax; its limited usefulness.


Use of omentum as a pelvic diaphragm following the resection of perforating carcinoma of the rectosigmoid.


Digitalis and the cardiovascular system.


Carcinoma of the fundus uteri.

Carcinoma of the fundus uteri.


Periarteritis nodosa; clinical manifestations and postmortem findings with a report of six cases.


The effect of transthoracic vagotomy upon the functions of the stomach and upon the early clinical course of patients with peptic ulcer.


The use of perforated acrylic implants following enucleation.


Failure of lipid metabolism; proctologic significance.


Primary and secondary metastases from cancer of the colon and rectum.


Use of neostigmine (prostigmine) in subacute poliomyelitis.


Importance of vitamins of the B complex in clinical medicine.


North Carolina School-Health Coordinating Service.


Some future problems in allergy.

Some future problems in allergy.


The disabled, the physician and employment.


Industrial health; a report from the field.


Common skin diseases in children.

Common skin diseases in children.


Pre-measles encephalitis.

Pre-measles encephalitis.


Experiments in medical education and medical care in a new medical school.


Some usual and unusual mechanisms of abdominal pain.


Protein solution in surgical practice.

Protein solution in surgical practice.


The use of diathermy in general practice.


Punishment by incineration.

Punishment by incineration.


Tetralogy of Fallot.

Tetralogy of Fallot.


Clinical observations in literature.

Clinical observations in literature.


The incidence of site of mandibular fractures.


The mammary tumor agent and its implication in cancer research.


Harvey, Riolan, and the discovery of the circulation of the blood.


Changes in liver function during experimentally induced human hepatitis.


Genetic analysis of the induction of tumors by methylcholanthrene; mutation from brown to black with a concomitant increase of susceptibility to fibrosarcoma.


Electroencephalographic changes after eye opening and visual stimulation.


Benzyl penicillin; failure to sterilize the blood in subacute bacterial endocarditis.


Eosinophilia, ancylostomiasis, and strongloidosis in the South Pacific area.


Salt depletion, peripheral vascular collapse, and the treatment of diabetic acidosis.


The possibility of detecting individual proteins in blood serum by differentiation of solubility curves in concentrated sodium sulfate solutions.


The housing, care, and surgical handling of laboratory primates.


The R.A.M.C. in Thailand.

The R.A.M.C. in Thailand.


The R.A.M.C. in Thailand p.o.w. camps.

The R.A.M.C. in Thailand p.o.w. camps.


Resuscitation under spinal anaesthesia without drugs.


Experiences with cholera in a jungle camp in Thailand.


A series of over 100 amputations of the thigh for tropical ulcer.


The nature of starvation amblyopia.

The nature of starvation amblyopia.


European into coolie; p.o.w. adapt themselves to the tropical villagers' diseases.


Leptospirosis (Weil's disease).

Leptospirosis (Weil's disease).


CONDITION of battle casualties returned from European Theater of Operations.


A report of ten cases of tetanus.

A report of ten cases of tetanus.


The surgical biopsy.

The surgical biopsy.


Infection of war wounds by Clostridium organisms (gas gangrehe).


An instance of possible penicillin sensitivity.


Identification of x-ray films in the field; flash box system of marking.


A new type of folding chest, designed for artillery battalion aid stations in the offensive.


Malnutrition in repatriated prisoners of war.


Observations and data on prevention of poison-oak dermatitis.


Comparative evaluation of preparations for the prophylaxis and treatment of fungous infections of feet.


Diagnosis of infestation with Sarcoptes scabiei var. hominis.


Aerodontalgia occurring during oxygen indoctrination in the low-pressure chamber.


Malaria in Panama.

Malaria in Panama.


PARTITIONING of barracks; effect on morbidity rates from respiratory disease.


Fractures of the shaft of femur; early treatment on a hospital ship.


Dental problems on submarines.

Dental problems on submarines.


An experience with atabrine aboard a troop transport.


Shigellosis studies; clinical observations on dysentery caused by Shigella flexneri III.


Trivial symptoms following extensive skull fracture.


Ophthalmic disease treated with penicillin.


Treatment of infected sebaceous cysts.

Treatment of infected sebaceous cysts.


Hookworm disease in infants; report of two fatal cases.


PHYCHIATRY and the problem of homosexuality.


A heavy-duty, high-capacity portable suction pump for surgical use.


Medical surveys for pulmonary tuberculosis.


Fundamental research in relation to the community.


Planned research.

Planned research.


Planning and organising research.

Planning and organising research.


Economic aspects of research.

Economic aspects of research.


The human factor.

The human factor.


Education and training of research workers.


The place of science in town and country planning.


International scientific co-operation.

International scientific co-operation.


Emergent energy.

Emergent energy.


New cosmic ray radiosonde techniques.

New cosmic ray radiosonde techniques.


Enzymes hydrolyzing ribo- and desoxyribonucleic acids.


Sounding upper atmosphere by radiosonde.


An empirical evolutionary generalization viewed from the standpoint of phenogenetics.


Coal tar and its derivatives; by-product recovery from coal tars in India.


Chance as a cause of changes in gene frequency within pure breeds of livestock.


Observations and experiments on the cave fish Pimelodella kronei and its relatives.


Australian agar agar industry.

Australian agar agar industry.


Electrolytic reduction of nitro compounds; the electrolytic reduction of nitrobenzene.


An estimate of the number of cell generations preceding sperm formation in Drosophila melanogaster.


Electrolytic reduction of nitro compounds; the electrolytic reduction of nitrobenzene to para aminophenol.


Electrolytic reduction of nitro compounds; the electrolytic production of benzidine.


Structural chromosome variability in urban and rural populations of Drosophila funebris.


Yeast growth method for thiamin estimation.


SCIENTIFIC management and the Civil Service.


Nutrients in British-grown and imported wheat.


Higher education in the British Colonial Empire.


Organs of equilibrium in flying insects.


Bacterial root nodules in the Zygophyllaceae.


Staining the chromosomes of yeast by the Feulgen technique.


Coupling of phosphorylation and oxidation processes.


Toxicity of D.D.T. to man.

Toxicity of D.D.T. to man.


Effect of duration of loading on the strength of glass.


Sugar of human semen.

Sugar of human semen.


A simple electrophoresis method.

A simple electrophoresis method.


Translocation of copper ions in plants.

Translocation of copper ions in plants.


The scientist and his government.

The scientist and his government.


Suppressed-range recording peak voltmeter.


A contact modulated amplifier to replace sensitive suspension galvanometers.


Range extender for general radio 760A sound analyzer.


The biological basis of imagination.

The biological basis of imagination.


Science and world community.

Science and world community.


Where are America's research resources?

Where are America's research resources?


Men, mastodons, and myth.

Men, mastodons, and myth.


The need for science writing in the press.


Gold shadowing in electron microscopy.

Gold shadowing in electron microscopy.


The nature and need of educational research.


The structure and synthesis of the liver L. casei factor.


Famine edema and the mechanism of its formation.


Antibacterial action of phenanthrene-related substances.


Carbon dioxide as an essential factor in the bacterial decomposition of cellulose.


The intraneural topography of the radial, median and ulnar nerves.


The role of galvanism in the treatment of denervated voluntary muscle in man.


The interrelation of the striopallidum and the thalamus in the macaque monkey.


Note on the lateral geniculate body.

Note on the lateral geniculate body.


The psychoneurotic veteran.

The psychoneurotic veteran.


Neurological complications of essential purpura haemorrhagica.


The physician's field workers for mental health.


Neurosis; a progressive or self-limiting disease?


Numerical and regional distribution of taste buds on the tongue of the bird.


Encephalitis, type undetermined.

Encephalitis, type undetermined.


The pyramidal tract; the sensitivity of axons to maximal injury of cells of origin in the cat.


The olivary peduncle and other fiber projections of the superior olivary complex.


Connections of the cerebral cortex; the albino rat; topography of the cortical areas.


Outcome of the tic syndrome.

Outcome of the tic syndrome.


Psychopath-like behavior in war neurotics.


Psychiatric study of a patient with paroxysmal hypothalamic dysfunction.


Neuropathologic manifestations found in a Japanese prison camp.


Sleep and third circulation; an attempt to solve the problem of sleep.


Speech disorders in World War II; dysarthria and dyslalia; methods of examination.


Shock treatment of psychoses associated with pregnancy.


Skin reactions observed under wartime stress.


Intracranial aneurysm and polycystic kidneys.


Involuntary imitative movements of contralateral hand.


Some relationships between maturation and acculturation.


Cultural patterning of maturation in selected primitive societies.


Psychotherapy and psychoanalysis in the treatment of children.


Totemistic mentation and its implications for child analysis.


Analytical psychology applied to children.


A fundamental concept for analytical psychology of childhood; paternus and materna.


The decisive influence of parental attitudes.


Should the child be sent to an institution?


Child guidance work based on psychoanalytic concepts.


Social psychiatry as an aid to child analysis.


Educational advantages enjoyed by handicapped children.


Social nursing.

Social nursing.


Male fever nurse; pioneer in the field.

Male fever nurse; pioneer in the field.


Anaesthetics in relation to nursing.

Anaesthetics in relation to nursing.


Puerperal sepsis.

Puerperal sepsis.


EYE injuries; penicillin.

EYE injuries; penicillin.


Structure and diseases of the nose and throat; anatomy and physiology of the nose.


RESPONSIBILITIES of superintendent health visitors.


Interlobar empyema.

Interlobar empyema.


Staphylococcal infections of newborn infants.


The mock accident in first-aid training; poisoning by carbon monoxide.


The value of educational psychology; modern methods and their uses in schools of nursing.


A case history of acute idiopathic porphyria.


HEALTH centre in Africa.

HEALTH centre in Africa.


Doctors meet challenge of cerebral palsy.


Diagnostic hospitals make contribution.

Diagnostic hospitals make contribution.


Army nurses did superb work.

Army nurses did superb work.


Rheumatic fever strikes quickly.

Rheumatic fever strikes quickly.


The effect of peripheral stimulation on central acuity.


Clinical results with feincone contact lenses.


The isotonicity of contact lens solution.


Notes on accommodative training procedures.


Toxic amblyopia and color field charting.


Chess and checkers for the blind.

Chess and checkers for the blind.


An analysis of braille reading.

An analysis of braille reading.


Social insurance for the blind.

Social insurance for the blind.


Opportunities in agriculture for the blind.


SOUNDS changed into visual pattern by new device in Bell Laboratory.


A study of the usefulness of objective measures of mechanical aptitude in guidance programs for the hypacousic.


An oral school in Kentucky one hundred years ago.


A contribution to the theory of the mechanism of the auditory apparatus.


Leeches as temporary endo-parasites in the upper respiratory tract of man.


Purpura induced by the initial injection of a pertussis vaccine.


Tuberculous splenomegaly in children; review of the literature and report of a case.


The influence of bronchial asthma on the heart in childhood.


Diphtheria; toxic myocarditis; diphtheria with nephritis.


Acute pyelitis in infancy; report of three cases.


DRUGS for treatment of trench mouth.

DRUGS for treatment of trench mouth.


DEVELOPMENTS in tableting.

DEVELOPMENTS in tableting.


Hormones in gynecology.

Hormones in gynecology.


Opium.

Opium.


Diffusion of sulfonamides from emulsified ointment bases.


The status of tyrothricin as an antibiotic agent for topical application.


Studies on Indian rhubarb; Rheum emodi.

Studies on Indian rhubarb; Rheum emodi.


Increase in fatality rate of E. typhosa for white mice by streptomycin.


The determination of phenolphthalein in mineral oil emulsions.


PENICILLIN production.

PENICILLIN production.


Compressed tablets.

Compressed tablets.


PHYSIOLOGIC and therapeutic aspects of acetylcholine.


Sources of error in germicidal activity tests with quaternary ammonium compounds.


Concentrated sprays tested for utility in control of flies and mosquitoes.


Deodorized petroleum base oils.

Deodorized petroleum base oils.


A polarographic study of alkaloids.

A polarographic study of alkaloids.


The intestinal excretion of sulphanilylbenzamide in comparison with sulphanilamide, sulphathiazole and sulphaguanidine; its bearing on the efficacy of compounds effective in bacillary dysentery.


A review of recent progress in ointment therapy.


Pharmacopoeial kaolin.

Pharmacopoeial kaolin.


The characteristics of magnesium trisilicate.


Investigations on the autoxidation of diethyl ether; autoxidation products and the autoxidation process.


The action of some drugs on the excised spleen.


Some observations on the pharmacology of the sphincter of Oddi.


Potentiation of insulin hypoglycaemia by nicotinyl taurine (beta-nicotinamidoethanesulphonic acid).


IS MALARIA coming to your town this summer?


Social remedies for social diseases.

Social remedies for social diseases.


INVISIBLE danger; some recently recognized complications of transfusion.


DOCTORS' disease; a vanishing syndrome?

DOCTORS' disease; a vanishing syndrome?


NUTRITIONAL qualities of breast milk.

NUTRITIONAL qualities of breast milk.


QUINONE VS. AMINE; hypertension and vitamin K.


PENTOTHAL sodium; review of recent literature.


D.D.T. poisoning; a future problem for the practitioner.


The pressure-volume diagram of the thorax and lung.


Accuracy of indirect determinations of blood pressure in the rat; relation to temperature of plethysmograph and width of cuff.


The effect upon the colon of electrical stimulation of forebrain areas in the cat.


Portal pressure gradients under experimental conditions, including hemorrhagic shock.


Performance as related to composition of alveolar air.


A study of oxygen transport in the blood of young and adult domestic ducks.


Denitrogenation of muscle and fat tissues of the anesthetized cat.


Survival of the isolated respiratory center in the young rat as influenced by adrenaline, ephedrine, insulin and glutathione and the relation to glycemia changes.


Cholinesterases in degenerating and regenerating peripheral nerves.


The differentiation of potassium from other agents associated with the toxic effects of tourniquet shock.


Body cooling of rats, rabbits and dogs following immersion in water, with a few observations on man.


Biological energy transformations during shock as shown by tissue analyses.


The rôle of sensory and motor cortical projections in escape and avoidance conditioning in dogs.


The enterohepatic circulation of foreign bile acids; the circulation of cholates in hogs with biliary fistulae.


Venous pressure changes associated with positive intrapulmonary pressures; their relationship to the distensibility of the lung.


Sympathomimetic amines: the relation of structure to their action and inactivation.


The fixation of carbon dioxide and the inter-relationships of the tricarboxylic acid cycle.


The effect of body temperature on drug action.


The viability of isolated nerve fragments and its modification by methylene blue.


A neglected factor in studies of potassium distribution in relation to the resting potential of nerve.


Lipins and lipidoses.

Lipins and lipidoses.


Organizers in development and the organizer concept.


The thromboplastic effects of tissue extracts and their inhibition by immune sera.


Innate and acquired behavior affecting the aggregation of fishes.


Elasticity of muscle in relation to actively developed twitch tension.


Reversible heat inactivation of Cypridina luciferase.


True cholinestererases with pronounced resistance to eserine.


The reactions of Culex larvae and pupae to gravity, light, and mechanical shock.


The effect of adenosinetriphosphate on the viscosity of actin solutions.


Effect of weak alternating-current shocks upon the division of Stylonychia pustulata (Ehrenberg).


The effects of noise on school children; an interpretive digest and recommendation.


Correlates of handedness among college freshmen.


The validity of certain objective techniques for measuring the ability to translate German into English.


Regression lines for estimating intelligence quotients and American Council examination scores.


Note on a comment on the correction of reliability coefficients for restriction of range.


Studies of motor functions in schizophrenia; steadiness.


The influence of emotional subject matter on logical reasoning.


An exploratory study of discrimination of composer style.


Discrimination of ambivalent cue stimuli by macaque monkeys.


A comparison of learning and retention of materials presented visually and auditorially.


The Nebraska Army Alpha Revision and the comparative strength of factors V,N, and R in nursing students.


Brain sensitization in personality disorders.


Relaxation in psychotherapy.

Relaxation in psychotherapy.


A memory drum for paired associate learning.


Replanning Britain's health services.

Replanning Britain's health services.


Education and the extension of public health services.


Observations in an outbreak of Streptococcus haemolyticus infection at an R.C.A.F. station.


Interim report on the activities of the Committee on Joint Causes of Death.


Public health nursing in the control of syphilis and gonorrhoea; how the public health nurse can assist the medical officer of health.


A review of the uses of the insecticide DDT in the control of insect pests affecting humans.


MOBILE dental unit now operating.

MOBILE dental unit now operating.


Permanent enrichment of flour and bread.


Chronological age versus physiological age.


Serological tests for syphilis in Connecticut 1945.


An experimental study on cellular immunity in Pasteurella pestis infection.


The natural ventilation of unheated closed rooms.


Some methods of measuring ventilation.

Some methods of measuring ventilation.


Bactericidal effects of the partial irradiation of a room with ultra-violet light.


A localized outbreak of Salmonella food poisoning apparently transmitted by a hen's egg.


A critical examination of the organism described as Bacillus wakefield.


The incidence of natural diphtheria antitoxin in horses; its influence on the results of antigenic stimulus.


The epidemic curve for mumps.

The epidemic curve for mumps.


Analysis of meals served in Surrey school canteens.


Iodine as an aerial disinfectant.

Iodine as an aerial disinfectant.


The statistical treatment of measurements of the carcinogenic properties of tars and mineral oils.


The problem family in the Netherlands.

The problem family in the Netherlands.


MEDICAL treatment of school children.

MEDICAL treatment of school children.


The prevention and treatment of tinea pedis.


Notified measles, 1940-45.

Notified measles, 1940-45.


Notified measles, 1940-1945; a note on the serial batch fatality rates.


The maintenance of a strain of Plasmodium vivax through man and mosquito over a period of 21 years.


The laboratory diagnosis of smallpox.

The laboratory diagnosis of smallpox.


An outbreak of gastro-enteritis due to Salm. thompson.


The Teviot report.

The Teviot report.


Some problems in rural public health.

Some problems in rural public health.


The treatment of cancer.

The treatment of cancer.


Training public health workers.

Training public health workers.


The nature of the soluble antigen from typhus rickettsiae.


Antibacterial action of penicillin, penicillin X, and streptomycin on Hemophilus influenzae.


CHARTER for school health; a review.

CHARTER for school health; a review.


A method for the preparation of tsutsugamushi (scrub typhus) antigen from infected yolk sacs.


Outbreak of Q fever in the United States.


The status of required physical education in colleges and universities of the United States.


Anthropometric characteristics and physical fitness.


Relation between leg-lift and sit-up.

Relation between leg-lift and sit-up.


An analysis of the physical education programs of the Minnesota secondary schools.


A comparative analysis of secondary-school boys' and girls' character and personality traits in physical education classes.


Standardization of a badminton knowledge test for college women.


A differential analysis of sit-ups for strength and muscular endurance.


Onchocerciasis.

Onchocerciasis.


Plain aeration of sewage.

Plain aeration of sewage.


Effect of food wastes on sewers and sewage treatment.


Treatment of cyanide and acid plating wastes.


REPORT of procedure for the handling of industrial wastes.


The distribution of radiation in the atomic bombing of Nagasaki.


Supervoltage radiation; a review of the cases treated during an eight year period (1937-1944 inclusive).


The management of malignant tumors of the testis.


Intrapulmonary air pressure and its relation to pulmonary capillary flow.


Diagnostic problems in fractures of the foot and ankle.


Emphysematous gastritis.

Emphysematous gastritis.


Heat capacities of roentgen-ray tubes; with particular reference to use for mass survey work.


Some procedures facilitating roentgenologic interpretation in an induction station.


An analysis of the physical factors controlling the diagnostic quality of roentgen images; contrast and the film contrast factor.


A recent visit with French radiologists.


From the memoirs of a student in Röntgen's laboratory in WArzburg half a century ago.


Some uses for the tomograph.

Some uses for the tomograph.


The pneumodigraph.

The pneumodigraph.


Radiography; an essential aid in obstetrical and gynaecological practice.


The decline of the male radiographer.

The decline of the male radiographer.


The value of orchiectomy in the treatment of carcinoma of the male breast.


The problem of secondary infection in carcinoma of the cervix.


Roentgen diagnosis of knee-joint effusion.


Indications and limitations of transvaginal roentgen therapy for cancer of the cervix.


Extrapleural pneumothorax in the treatment of pulmonary tuberculosis.


A comparative clinical investigation of cholecystographic preparations.


The so-called retarded or occult fractures.


March fracture.

March fracture.


Hiatus hernia of the stomach as a source of gastro-intestinal bleeding.


Lymphoblastoma of the kidney.

Lymphoblastoma of the kidney.


Paragonimus westermanii.

Paragonimus westermanii.


Two cases of spinal anomaly, best demonstrated by laminagraphy.


Spontaneous renocolic fistula.

Spontaneous renocolic fistula.


Bronchial asthma; new etiologic and therapeutic approach.


Appendicitis in combat zone as seen in a field hospital.


A method of continuous brachial plexus block.


Indications and advantages of complete abdominal hysterectomy versus incomplete hysterectomy.


Abdominoperineal proctosigmoidectomy for cancer of rectum; conclusions based on five years' experience.


Traumatic aneurysms of the extremities.

Traumatic aneurysms of the extremities.


Genital tuberculosis in women.

Genital tuberculosis in women.


Bilateral Petit's hernia and an anterior sacral meningocele occurring in the same patient.


Trauma to the abdomen.

Trauma to the abdomen.


Varicocele.

Varicocele.


Management of intertrochanteric fractures of the femur by skeletal traction with the beaded Kirschner wire.


Inguinal herniorrhaphy from the intra-abdominal perspective; retention of the sac and intact external ring, and a means for proving the adequacy of the repair.


A device to simplify end-to end anastomosis of the large bowel; the elimination of unequal diameters of the two segments to be anastomosed.


Total gastrectomy for complete carcinomatous involvement of the stomach.


Multiple argentaffin tumors (carcinoids) of the rectum.


Reconstruction of thumb.

Reconstruction of thumb.


Osteomyelitis of the frontal bone and subdural empyema with recovery.


Hyperparathyroidism due to parathyroid adenoma.


Streptomycin in the treatment of surgical infections; report of experiences with its use.


Physiologic considerations in the care of patients with varicose veins.


Treatment of an unusual subdural hydroma (external hydrocephalus).


Treatment of fractures of the carpal scaphoid; a report of sixty-four cases.


Diagnosis of acute appendicitis in the presence of diarrhea.


Penicillin ointment-impregnated gauze in the local treatment of infections.


A surgical specimen consisting of a partially developed parasitic fetus.


Review of urologic surgery.

Review of urologic surgery.


Observations on radical surgery for lesions of the pancreas.


Primary suture of nerves.

Primary suture of nerves.


A clinical and pathologic study of the kidney in patients with thermal burns.


A new method of treatment for severe fractures of the os calcis; a preliminary report.


Large retroperitoneal metastasis from a so-called carcinoid of the small intestine.


Intrathoracic tumors of the sympathetic nervous system.


Pilonidal cyst; analysis of 100 consecutive cases, emphasizing treatment by radical excision, primary closure and penicillin therapy.


The lateral aberrant thyroid.

The lateral aberrant thyroid.


Urinary incontinence due to bilateral ectopic ureters.


Studies on exophthalmos produced by thyrotropic hormone; further study of changes induced in fat by thyrotropic hormone (tissue reactions associated with exophthalmos).


Spontaneous gastrointestinal biliary fistulas.


Ruptures of malarial spleens unassociated with external trauma.


Experimental surgical pulmonary collapse.


Burns; colective review.

Burns; colective review.


The Rh factor-serologic background and clinical application.


Sex difference in the size of the thymus in guinea-pigs.


Quantitative investigations on the anterior pituitary body of castrated rats with reference to the absolute cell conditions and their significance.


Experiments into the action of testosterone propionate on the kidneys of male rabbits.


Sulfathiazole as a medication for American foul brood disease of honeybees.


Diatomaceous diluents for dusts.

Diatomaceous diluents for dusts.


Chemical methods for analysis of dichloro-diphenyltrichloroethane (DDT).


DDT on peaches; three years field experiments.


DDT and other new insecticides for control of cauliflower worms on Long Island.


DDT as a control for the pea aphid.

DDT as a control for the pea aphid.


DDT to control potato aphids.

DDT to control potato aphids.


DDT and ryanex to control oriental fruit moth; their effect upon parasite populations.


DDT for codling moth control in western New York in 1945.


New formulations of aerosols dispersed by liquefied gases.


DDT preparations for control of the pea aphid.


Particle-size distribution in liquefied-gas aerosols.


The thermal aerosol for generator for large scale application of DDT and other insecticides.


Control of the American dog tick, a vector of Rocky Mountain spotted fever; preliminary tests.


DDT thermal aerosol fogs to control clothes moths in a wool storage warehouse.


Rate of development of milky disease in Japanese beetle populations.


Eradication of boxwood leafminer and the boxwood psyllid.


The control of mites on apple trees sprayed with DDT.


Individual comparisons of grouped data by ranking methods.


Compatibility of DDT and fungicides on potatoes.


Two industry problems caused by release of DDT.


DDT for control of a book louse.

DDT for control of a book louse.


Studies on the pharmacology of cholic acid.


Rôle of methemoglobinemia in protection against and treatment of inhalation poisoning by HCN and CNCl.


Proposals concerning the nomenclature of the gill fungi including a list of proposed lectotypes and genera conservanda.


Curative effect of plasmoquin in Plasmodium lophurae infections.


Synergisms and antagonisms between physostigmine and di-iso-propyl fluorophosphate.


The chronic toxicity of di-isopropyl fluorophosphate in dogs, monkeys and rats.


The effect of coumingine on the contractile force of isolated mammalian cardiac muscle.


Studies on some fungi from northwestern Wyoming; fungi imperfecti.


On the expectorant action of cholinergic drugs.


Aerosol OT in the preparation of microscopic mounts of fungi.


The effects of di-isopropyl fluorophosphate upon normal and glaucomatous eyes.


A preliminary survey of certain lactone antibiotics.


Inhibitory potency of sympathomimetic amines and their ganglionic inhibitory action.


The protective action of atabrine against chloroform-adrenaline ventricular fibrillation.


Toxicity of certain halogenated aliphatic acids for mice.


Relation of structure to activity in a new series of sympatholytic agents.


Effect of anti-reticular cytotoxic serum on the healing of experimental wounds in rats.


The effect of phloridzin on the renal excretion of mercury.


Chemotherapy of Plasmodium knowlesi infections in Macaca mulatta monkeys.


Dose and intensity of action and elimination of prostigmine.


The response of fatigued myocardium to known concentrations of a cardiac glycoside.


The action of 1,1-diphenyl-1-(dimethylaminoisopropyl)-butanone-2, a potent analgesic agent.


Pharmacological studies of anti-histamine compounds.


Determination of salicylate fractions in urine following the administration of salicylates.


The influence of streptomycin and promin on the proliferation of tubercle bacilli in the tissues of the albino rat.


Detection of oxidation-reduction by alkaline solutions of methylene blue and orcein.


Depression of metabolism and temperature in traumatic shock as evidence of a toxic factor.


Pamaquin; suppressive antimalarial activity in vivax and falciparum malaria.


Studies on the fate of tri-p-anisyl chloroethylene and hexestrol.


Chemotherapeutic studies on experimental leishmaniasis.


Toxicity of methylamino-iso-octene (octin).


The relation between the chemical structure of DDT and its toxicity with oral administration to mice.


The effect of cyanide on the electrocardiogram of man.


Cinchona alkaloids; suppressive antimalarial activity of cinchonine carbostyril.


Effects of a cycle of morphine addiction on conditioned responses and experimental neuroses in dogs.


Intrasplenic ovarian grafts in the guinea pig and the problem of neoplastic reactions of the graft.


Evidences of increase in the capacity of the pulmonary arteries and veins of dogs, cats and rabbits during inflation of the freshly excised lung.


Surgical anatomy; Langer's muscle of the axilla.


Radiographic vignettes; the supracondylar process.


The physiology of immobilization and the local effects of heat and cold.


Medical significance of ocular torticollis.


The problem of Ewing sarcoma of bone.

The problem of Ewing sarcoma of bone.


Metastatic neoplasm of pelvic bones treated by stilbestrol.


Salmonella osteomyelitis.

Salmonella osteomyelitis.


Report on the use of penicillin in the treatment of staphylococcal infections with special reference to acute and chronic osteomyelitis and several collateral studies.


Surgical house cleaning in osteoarthritis of the knee.


The orientation of the joints of the lower extremity.


Spontaneous rupture of the bladder complicating treatment of fracture of the lumbar spine.


The relation of the extensor digitorum communis tendon to the metacarpophalangeal joint.


Stenosing tendovaginitis of the flexor longus pollicis disability other than trigger thumb.


The glomus tumor.

The glomus tumor.


The carcinogenicity of p-monomethylaminoazobenzene in various diets and the activity of this dye relative to p-dimethylaminoazobenzene.


Calcium, copper, and zinc in the epidermal carcinogenesis of mouse and man.


Carcinogens and the regeneration patterns after injury.


The etiology of fowl tumors.

The etiology of fowl tumors.


Some practical considerations of the rheumatic fever problem.


The symballophone.

The symballophone.


The volumetric determination of nitroguanidine.


Notes on the selective oxidation of vinegar.


The determination of boron by the use of quinalizarin.


The gravimetri determination of tin in alloys by the tannin method.


The determination of selenium in copper mattes.


Note on the presence of heat-labile sulphur in milk powder made from milk pre-heated at a high temperature (190-200 degrees F.).


The rapid determination of sodium in 50 per cent potassium hydroxide liquor, 50 per cent potassium carbonate liquor and solid potassium carbonate.


Note on technique for microbiological assay of vitamins by methods involving mould growth.


The use of cupferron for the estimation of large quantities of iron in faeces.


A note on the determination of nitrogen in foodstuffs by the Kjeldahl method; digestion conditions.


Detection of manganese with aurintricarboxylic acid.


A carbonate estimation apparatus.

A carbonate estimation apparatus.


The determination of lime in refractory dead-burned magnesia.


The efficiency of desiccants.

The efficiency of desiccants.


The continuous production of doubly distilled water.


A thermostatically-controlled low temperature bath.


The tryptophane activity of various compounds for L. arabinosus and their influence on the determination of tryptophane in natural materials.


Factors influencing the maintenance of blood concentrations of sulfonamides.


A growth factor for Lactobacillus gayoni 8289.


The excretion of B-complex vitamins in the urine and feces of seven normal adults.


Quantity and quality of amylase produced by various bacterial isolates.


Essential amino acid content of casein and fresh and processed cow's milk as determined microbiologically on hydrolyzates.


Application of nutritional studies for development of practical culture media for Bacillus anthracis.


Studies on the nutritional requirements of Bacillus anthracis.


On the respiration of dermatophytes.

On the respiration of dermatophytes.


A submicro method for the determination of iodine number of lipids.


The folic acid content of meats and the retention of this vitamin during cooking.


Changes in polyene synthesis induced by mutation in a red yeast (Rhodotorula rubra).


The content and biological availability of carotene in raw and dehydrated carrots and other vegetables.


The content and biological availability of carotene in dehydrated carrots stored at high temperatures.


Observations on the inheritance of latex quality in Cryptostegia.


A triterpene ester isolated from Cryptostegia madagascariensis latex.


The carbonyl constituents of eucalyptus oils; the constitution of phellandral; d-, 1-, and d1-Beta isopropyladipic acids.


Attempts to find new antimalarials; derivatives of 3:4:2':3'-pyridoacridine and 1:2:2':3'-pyridoacridine.


Attempts to find new antimalarials; derivatives of o-phenanthroline (7:8:3':2'-pyridoquinoline).


The synthesis of antimalarial compounds related to niquidine; model experiments on the synthesis of quinolyl carbinols.


Recent work on corrosion and oxidation.

Recent work on corrosion and oxidation.


Hydroxamic acids from aliphatic dicarboxylic acids.


Substituted alpha-dialkylaminoalkyl-l-naphthalenemethanols; some Mannich ketones and derived propanolamines.


Substituted alpha-dialkylaminoalkyl-l-naphthalenemethanols; synthesis of some propanolamines by means of Grignard reagents.


Substituted alpha-dialkylaminoalkyl-l-naphthalenemethanols; 5-, 6-, and 7-chloro derivatives.


The use of the fused eutectic of sodium amide and potassium amide in organic syntheses.


7-Acetoxy-9-acetyl-1,2,3,4-tetrahydrophenanthrene and dialkylamino carbinols derived from it.


3-(2-Dialkylamino-1-hydroxyethyl) retene derivatives.


Antitubercular studies; heterocyclic fatty acids.


The preparation of 8-quinolinesulfonic acid.


Some decamethylene and undecamethylene diamines.


The preparation of some C-alkylmorpholines.


Attempts to find new antimalarials; amino alcohols of the type -CHOHCH(CH3)NR2 derived from tetrahydrophenanthrene.


Attempts to find new antimalarials; phenyl beta-D-glucothiosides, diphenyl disulfides, phenyl thiocyanates, and related compounds.


The application of radium and x-rays to diseases of the mouth.


The art of anaesthesia.

The art of anaesthesia.


How civilian internees fared for dental treatment in Hong Kong during the Japanese occupation.


THE Teviot Report.

THE Teviot Report.


A new approach to Hanau's laws of articulation.


Periodontia, its purpose and scope.

Periodontia, its purpose and scope.


Trismus due to myositis ossificans traumatica; report of a case.


Impacted lower third molar causing neuralgia and absorption of lower second molar.


Removal of multiple impacted teeth; report of a case.


Mixed salivary tumour of the palate.

Mixed salivary tumour of the palate.


Adamaninoma of the mandible; report of case.


Extensive cystic tumors of the mandible; report of case.


Paget's disease involving the maxilla and the mandible; report of a case.


Conservative treatment of dental root cyst; report of case.


Whither dentistry?

Whither dentistry?


Removal of two mandibular super-numerary teeth to allow eruption of lower second bicuspid.


Oral lesions of granuloma inguinale; report of three cases.


Submaxillary duct and gland stones; report of a case.


A myxomatous tumor simulating a dentigerous cyst.


Ameloblastoma of the mandible; report of a case.


Dentinoma; report of a case.

Dentinoma; report of a case.


Use of petrolatum as dressing in third molar sockets; report of a case.


Ranula (cystic tumor); report of case.

Ranula (cystic tumor); report of case.


Muco-epidermoid tumors of the salivary glands; a report of three cases.


Multiple lymphosarcoma (lymphoblastoma) of the oral and cervical regions.


Delayed union of mandibular fractures.

Delayed union of mandibular fractures.


Torus; report of case.

Torus; report of case.


Periodontal cyst; report of case.

Periodontal cyst; report of case.


Transitional cell carcinoma (lymphoepithelioma) of the upper jaw; report of case.


Psychogenic factors in oral disease.

Psychogenic factors in oral disease.


Fitting the patient to the denture.

Fitting the patient to the denture.


A comparative study of the resorption of alveolar ridge tissue under immediate dentures.


A report on two unusual partial dentures.


A comparison of some modern methods for obtaining stability and retention for lower dentures.


Dental disease as a fundamental problem.


A comparison of various materials used in taking mandibular impressions in complete denture prosthesis.


Gingivitis and penicillin administration.


Dermatitis of the hands due to atopic allergy to pollen.


Treatment of tinea capitia with special iodine and dilute acetic acid.


Treatment of tinea capitis with roentgen rays.