Proceedings: Effect of nicotine and nicotine monomethiodide on vascular adrenergic neuroeffector transmission.


Proceedings: Demonstration of the in vivo action of pepstatin: effects on plasma angiotensin II concentration (PAC).


Proceedings: Effects of antiphlogistic drugs on the adenyl cyclase system of fibroblasts.


Proceedings: Studies on the inhibitory effect of pepstatin on the renin--angiotensinogen reaction.


Proceedings: Effect of cholinergic mechanisms on rat gastric mucosal cAMP.


Proceedings: Synthesis of cyclic AMP and cyclic AMP-mediated protein phosphorylation in rat erythrocytes.


Proceedings: The ciliary ganglion of the cat: pharmacological aspects.


Proceedings: Effect of tropolone on vascular sympathetic neuroeffector transmission.


Proceedings: The effect of norepinephrine on cyclic nucleotide concentrations in rat ductus deferens.


Proceedings: Effect of the alpha-receptor blocking agent phentolamine on cAMP levels and release of glycerol in isolated rat fat cells.


Proceedings: Adenosine 3',5'-monophosphate in cerebral cortical slices from guinea pig and rat: effect of benzodiazepines.


The evaluation of the experience of various European countries in cancer control.


A fine structural study of human oral epithelium separated from the lamina propria by enzymatic action.


A cytoplasmic inclusion in mouse trigeminal neurons (1).


Primary breast cancer: some considerations concerning its management.


Effect of histone on oncogenic properties of Moloney's murine sarcoma virus.


Specificity of rabbit IgM and IgG antibody in intratypic differentiation of poliovirus type I strains.


Herpesvirus strigis: a new avian herpesvirus. I. Biological properties.


Precipitating antibodies against maedi-visna virus in experimentally infected sheep.


Nelson Bay virus. A novel reovirus.

Nelson Bay virus. A novel reovirus.


Biological and biophysical characterization of SV40 cytoplasmic T-antigen-inducing mutants of PARA-adenovirus 7.


Composition of poliovirus fibrils.

Composition of poliovirus fibrils.


In vivo behaviour of a temperature-sensitive (ts) mutant of herpesvirus hominis type 2.


Further studies on the development of Yaba poxvirus in cell culture.


Infections with herpesviruses in a closed infants' community.


Strain specific cell-mediated response to polyoma-transformed fibroblasts in mice.


Rational surgery for tumors of the ovary in children.


Brain lipid changes following hypoxia.

Brain lipid changes following hypoxia.


Applications of phospholipase C in the study of membranes.


Hyperlipoproteinemia--relation to platelet lipids, platelet function and tendency to thrombosis.


Postsynaptic effects evoked from brain stem reticular formation in lumbar cord and their temporal correlations with a presynaptic mechanism.


Tonotopic organization: review and analysis.


Cytochemical localization of cyclic nucleotide phosphodiesterase activity at developing synapses.


Signal transmission through degenerating synapses in the lateral geniculate body of the cat.


Phosphatases in the substantia gelatinosa and motoneurones: a comparative histochemical study.


Inhibition studies of dehydrogenases by structural analogues of NAD.


Binding of 3H-labelled cobra neurotoxin to cholinergic receptors in fast and slow mammalian muscles.


Cholinergic suppression of tardive dyskinesia.


Effects of methylphenidate on hyperactive children's sleep.


Treatment of respiratory distress in the newborn infant.


Sensory conduction of the sural nerve in polyneuropathy. Using surface electrodes, sensory nerve action potentials (SAP) have been recorded in the proximal segment (mid-calf to lateral malleolus) and the distal segment (lateral malleolus to toe 5) of the sural nerve and in the median nerve in 79 control subjects. The values obtained for the distal segment of the sural nerve varied widely and in seven apparently normal subjects no SAP could be distinguished. In the proximal segment conduction velocities were over 40 m/s and there was no significant change with age, unlike the median nerve in which a highly significant slowing occurred with age. Comparison of the results of sural and median sensory conduction studies in 300 consecutive patients screened for sensory polyneuropathy confirms the value of sural nerve sensory studies as a routine screening test, and confirms the belief that the changes in polyneuropathy are usually more prominent in lower limb nerves. It is therefore suggested that studies of sural sensory conduction form the single most useful test in the diagnosis of sensory polyneuropathy.


Nephroblastoma in a bovine fetus.

Nephroblastoma in a bovine fetus.


Pattern of recruiting human motor units in neuropathies and motor neurone disease. The pattern of recruiting human motor units in the first dorsal interosseous muscle of the hand has been studied in 31 patients with ulnar neuropathies and motor neurone disease. Two years after surgical repair of an unilateral complete severance of the ulnar nerve, the twitch tensions increased to normal size. However, the normal orderly pattern of recruiting motor units of increasing size during increasing voluntary contractions was irretrievably lost. Among patients with pressure or entrapment neuropathies, the normal orderly pattern of recruiting motor units was always retained. Similarly, in patients with motor neurone disease (amyotrophic lateral sclerosis), the orderly pattern of recruitment was not disrupted.


Ultrastructure of canine carotid body and aortic body tumors. Comparison with tissues of thyroid and parathyroid origin.


Ultrastructure of normal and neoplastic mast cells of the cat.


Aortic body tumor in a white rat.

Aortic body tumor in a white rat.


Cyclic adenosine-3',5'-monophosphate in cellular immunity.


Preliminary analysis of the effects of ATP-Mg on Escherichia coli K 12 aspartokinase I-homoserine dehydrogenase I, at low potassium concentration.


Congenital hyperphosphatasia.

Congenital hyperphosphatasia.


The action of barbiturates upon liver alcohol dehydrogenase. Their interference with alcohol metabolism.


Action of proteolytic and glycolytic enzymes on the permeability of the blood-brain barrier.


Activity of inactivated Burcella on murine tumors: prophylactic effects and combination with specific immunostimulation.


Experiences with a lyophilised contagious bovine pleuropneumonia vaccine in the Ivory coast.


Isolation and characterization of a novel lipid, 1(3),2-diacylglyceryl-(3)-O-4'-(N,N,N-trimethyl)homoserine, from Ochromonas danica.


Stimulation of alkaline phosphatase by analogs of inorganic pyrophosphate.


Magnetic resonance studies of the active-site region of thermolysin.


Kinetic and magnetic resonance studies of the interaction of oxalate with pyruvate kinase.


Quantitative interaction of Ricinus communis agglutinin and concanavalin A with influenza and vesicular stomatitis viruses and virus-infected normal and polyoma-transformed cells.


Antibodies to the codons ApApAp, ApApC, and ApUpG.


Stepwise degradation of polyribonucleotides.


Chemical probes of chromatin structure.

Chemical probes of chromatin structure.


Canine malignant mammary tumours. I. Sarcomas.


The relevance of the superoxide anion radical in biological systems.


Mesenchymal tumors of the uterus.

Mesenchymal tumors of the uterus.


The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells.


Pathophysiology of the Fallopian tube.

Pathophysiology of the Fallopian tube.


Complications of regional anesthesia in obstetrics.


Some kinetic and inhibition properties of human brain mitochondrial monoamine oxidase (EC 1.4.3.4).


Fibers projecting onto the crista ampullaris of the vertical anterior semicircular canal from other ipsilateral vestibular receptors in the frog (Rana esculenta).


Malignant liver tumors in children.

Malignant liver tumors in children.


Effects of some coenzymes and metabolic factors on experimintal atherosclerosis in animals.


Cytochrome c.

Cytochrome c.


Effects of 3', 5'-cyclic adenosine monophosphate, 5-hydroxytryptamine, noradrenaline and theophylline on the simultaneous release of peroxidase and amylase from the guinea pig submanibular gland.


Pituitary and plasma concentrations of adrenocorticotrophin, growth hormone, vasopressin and oxytocin in fetal and maternal sheep during the latter half of gestation and the response to haemorrhage.


Virus infections in bats.

Virus infections in bats.


In vivo metabolism of 14C-labeled palmitic acid in serum and in brown and white adipose tissue of well-fed and starved newborn rabbits. II. Tracer kinetic analysis of the incorporation rate of serum free fatty acids into the main lipid fractions of brown and white adipose tissues.


Use of immunoperoxidase for the rapid identification of human myxoviruses and paramyxoviruses in tissue culture. The immunoperoxidase method, using commercially available antisera, was compared with standard virological methods for the identification and typing of 77 isolates of human myxoviruses and paramyxoviruses. Results of typing using neutralization tests and the immunoperoxidase technique were identical for 76 of the 77 isolates. With the immunoperoxidase method there was one false negative reaction, but no false positive reactions. Cross-reactivity between influenza A (soluble) and A(2)/HK antisera with influenza A isolates was noted, but did not interfere with the interpretation of results. It is concluded that the immunoperoxidase method is ideally suited for the rapid identification and typing of common human respiratory viruses on a routine basis. It offers a number of decided advantages over both immunofluorescence and standard virological methods.


Unsuspected tumors in aircraft accident fatalities as a guide to evaluation of physical-examination standards.


Biophysical-immunological assay for ribonucleic acid type C viruses. A biophysical and immunological method for characterization of ribonucleic acid type C virus suspensions is described. The method provides a relationship to the total viral mass concentration of the particle titer, the gs antigen titer, and the ultraviolet absorbance (268 nm) of 2% sodium dodecyl sulfate digests. Data for murine, rat, feline, and hamster viruses are shown to be analogous within the test limitations. From these data, an assessment of the viral purity can be made, the structural integrity can be evaluated, an approximate molecular weight can be computed, and the mole ratio of gs antigen can be determined.


Biosynthesis of nitrogenous phospholipids in spinach leaves.


Preparation and properties of purified (Na+ plus K+)-stimulated mitochondrial ATPase from germinating pea seeds.


Glycosphingolipids in secondary lysosomes prepared from rat liver.


Ultrastructural findings in a well-differentiated hepatoma.


Quantitative hepatic cytology. Experimental study.


Herpes encephalitis.

Herpes encephalitis.


Electroencephalographic patterns in herpesvirus encephalitis.


Purification and partial characterization of an endonuclease from Palaemon serratus hepatopancreas.


Pancreatic islet cell carcinoid: a highly malignant form of carcinoid tumor.


Culturing breast tumor cells in the presence of hormones.


Theory of chromatography of rigid molecules on hydroxyapatite columns with small loads. I. The case when virtually all molecules are adsorbed on to a single type of crystal site through a single type of adsorption group.


Solitary glomus tumours of the fingers.

Solitary glomus tumours of the fingers.


Proceedings: Ectopic parathyroid hormone-producing tumors.


Proceedings: An autopsy case of cholangiocarcinoma associated with pseudohyperparathyroidism.


Rescue of defective SV40 from a transformed mouse 3T3 cell line: selection of a specific defective.


Proceedings: Effect of dibutyryl cyclic AMP on the formation of dentin and bone in parathyroidectomized rats.


Properties of the ts3 mutant of polyoma virus during lytic infection.


Inhibitors of DNA synthesis: their influence on replication and transcription of simian virus 40 DNA.


Mapping temperature-sensitive mutants of simian virus 40: rescue of mutants by fragments of viral DNA.


Correlation between amino acid exchanges in coat protein of TMV mutants and the nature of the mutagens.


Molecular weights of plant viral RNAs determined by gel electrophoresis under denaturing conditions.


Regulation of synthesis of herpes simplex type 1 virus mRNA during productive infection.


High specific infectivity avian RNA tumor viruses.


RNA tumor viruses of pheasants: characterization of avian leukosis subgroups F and G.


Defective interfering particles from poliovirus vaccine and vaccine reference strains.


Hemagglutinating activity of bovine papilloma virus.


Simian virus 40 structural proteins: amino-terminal sequence of the major capsid protein.


Hybridization of simian virus 40 complementary RNA with nucleolus-associated DNA isolated from simian virus 40-transformed Chinese hamster cells.


"Huffer's" neuropathy.

"Huffer's" neuropathy.


A study of fine structural changes in the cartilage-to-bone transition within the developing chick vertebra.


The control of mastitis.

The control of mastitis.


Pathogenesis of peptic ulcer.

Pathogenesis of peptic ulcer.


Effects of 6-hydroxydopamine on an identified dopamine-containing neuron in the central nervous system of Planorbis corneus.


Potassium-induced release of amino acids from cerebral cortex and spinal cord slices of the rat.


Depression and frequency facilitation at a synapse in Aplysia californica: evidence for regulation by availability of transmitter.


Measurements of extracellular potassium, ECoG and pyridine nucleotide levels during cortical spreading depression in rats.


The effect of angiotensin II on neurones of the cat subfornical organ.


Dynamic patterns of brain cell assemblies. II. Concept of dynamic patterns. Dynamic patterns in chemistry.


Dynamic patterns of brain cell assemblies. II. Concept of dynamic patterns. Cell patterning.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Interneuronal connectivity. Gap junction ultrastructure.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Oscillating fields and pulse distributions. Relation of neuronal waves to EEG.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Oscillating fields and pulse distributions. Postsynaptic events.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Influence of exogenous low-level currents. Electrophysiological effects of direct currents.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Oscillating fields and pulse distributions. Pulse-wave problems.


Identification of viruses involved in the 1971 outbreak of hemorrhagic disease in southeastern United States white-tailed deer.


The 1971 outbreak of hemorrhagic disease among white-tailed deer of the southeastern United States.


Vaccination trials in desert bighorn sheep against bluetongue virus.


Proceedings: An attempt to localize cyclic phosphodiesterase at adrenergic nerve endings.


Proceedings: Synaptochemistry. Outlines and scope of a discipline.


Proceedings: Effects of papaverine derivatives on cyclic 3', 5'-AMP phosphodiesterase and relaxation of rabbit ileum.


Proceedings: Spinal transmission of autonomic processes.


Proceedings of the International Neurovegetative Symposium: Concluding remarks.


Spontaneous autoimmune diseases of domestic animals.


General neuropathology of degenerative processes of the nervous system.


Reactivation of chick erythrocyte nuclei by somatic cell hybridization.


Cyclic AMP levels in temperature sensitive SV40 transformed cell lines.


Studies on a Chinese hamster line that is temperature sensitive for the commitment to DNA synthesis.


Calcium transport in isolated bone cells. I. Bone cell isolation procedures.


Calcium transport in isolated bone cells. II. Calcium transport studies.


Comparative study of various methods for the extraction of free creatine and phosphocreatine from mouse skeletal muscle.


An assay for protein activity on polyacrylamide gels.


Quantitative measurement of hypermodified adenosine ribonucleosides in plant tissues.


A new rapid assay for measuring deoxycytidylate- and deoxythymidylate-kinase activities.


Acetonitrile-based solvents: their application in thin-layer chromatography of cyclic nucleotides, nucleosides, purine, and pyrimidines.


Experimental herpetic keratitis in the guinea pig.


Characteristics and distribution of spinal focal synaptic potentials generated by group II muscle afferents.


Studies on the postnatal development of the collecting ducts of the rat kidney, with particular reference to their glycogen content.


Ascorbic acid as an antioxidant in thin-layer chromatography of corticosteroids.


Separation of phosphatidyl inositomannosides of Mycobacteria.


Retinal lesions in rat after treatment with chlorphentermine or with tricyclic antidepressants.


Bone marking and lead intoxication. Early pathological changes in osteoclasts.


Lipidosis-like cellular alterations in lymphatic tissues of chlorphentermine-treated animals.


An ultrastructural analysis of early fertilization in the sand dollar, Echinarachnius parma.


Electron microscopic investigation of synaptic organization of the trochlear nucleus in cat. I. Normal ultrastructure.


Clinicopathological conference: Exanthem and pneumonia in a 3-year-old girl.


Circumscribed "giant-cell" glioblastoma.


Giant cell hepatitis with cytomegalovirus inclusions in an adult. A case report.


Plasma angiotensin-like activity in hypertension.


The use of solid medium cultures for the removal of bacteria and fungi from Entamoeba histolytica strains.


Studies on the effect of inactivated viruses on the growth of Poxvirus variolae. I. The influence of heating at temperatures: 70 degrees C, 56 degrees C and 37 degrees C on the infection activity of some viruses.


Syncytium formation of Japanese quail embryo fibroblasts on double infection with Rous sarcoma virus and measles virus.


Primary tissue culture of brain tumor using glass fiber.


Vincristine sulphate in the postoperative management of malignant supratentorial glioma.


Combined use of trimethoprim plus superseptyl and of trimethoprim plus superseptyl plus polymyxin B in Salmonella infections.


[Mechanism of action and cellular receptors of insulin (author's transl)].


The primary structure of DNA.

The primary structure of DNA.


Variola virus in the throat of healthy contacts of small-pox cases.


Treatment and prophylaxis in food handling amoebic cyst carriers.


A specific method for the assay of alcohol dehydrogenase in human liver and serum.


Identification and quantitative determination of 2-hydroxyoestriol in human late-pregnancy urine.


Steroid metabolism in testis tissue: concentrations of unconjugated and sulfated neutral steroids in boar testis.


Ligand specificity of progesterone-binding proteins in guinea pig and sheep.


Physiological variations in plasma testosterone in normal adult male subjects measured by a competitive protein-binding technique.


Simultaneous determination of cortisol, deoxycortisol and corticosterone in plasma and urine by competitive protein binding assay. Response of normal subjects to ACTH and metyrapone.


Binding of progesterone by rat myometrium during pregnancy and by human myometrium in late pregnancy.


Characterization of a specific androgen receptor in rat prostate cytosol by agargel electrophoresis. In vivo and in vitro studies.


Blood coagulation and fibrinolysis in Ugandan patients with cirrhosis and hepatocellular carcinoma.


Carriers and specificity in membranes. 3. Carrier-facilitated transport. Molecular motion in phospholipid bilayers and biomembranes.


Carriers and specificity in membranes. V. Neuron membranes. Membrane phenomena at the synapse.


Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene.


Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones.


Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 4. Bis-basic sulfonamides of anthraquinone.


The enzymology of cholesterol esterification.


Phospholipid substrate specificity of purified human plasma lecithin:cholesterol acyltransferase.


Cholesterol esterification by the rat liver Golgi apparatus.


Studies on enzymatic and molecular properties of lecithin:cholesterol acyltransferase.


Lecithin: cholesterol acyltransferase of human plasma. Role of chylomicrons, very low, and high density lipoproteins in the reaction.


In vitro determination of lecithin:cholesterol acyltransferase in plasma.


Factors determining the concentrations of lysolecithin in plasma and tissues.


Degradation of high-density lipoproteins (HDL) in vitro.


Isoelectric fractionation of plasma high-density lipoproteins.


Human plasma high-density lipoprotein composition during the menstrual cycle.


Apolipoproteins and lipoprotein families in familial lecithin: cholesterol acyltransferase deficiency.


Familial lecithin:cholesterol acyltransferase deficiency. Studies on lipid composition and morphology of tissues.


Familial lecithin:cholesterol acyltransferase deficiency--a clinical survey.


Familial lecithin:cholesterol acyltransferase deficiency. Report of a third Norwegian family with two afflicted members.


Lipid and lipoprotein abnormalities in liver disease: the possible role of lecithin: cholesterol acyltransferase deficiency.


Plasma cholesterol esterification in vivo in man.


Structural studies on serum lipoproteins in homozygotes and heterozygotes for the lecithin:cholesterol acyltransferase deficiency gene.


Current concepts of cholesterol metabolism and their relationship to lecithin:cholesterol acyltransferase.


Plasma lipoprotein metabolism in familial lecithin:cholesterol acyltransferase deficiency.


Milk inhalation pneumonia: the significance of fat filled macrophages in tracheal secretions.


Clinicopathologic conference: Coexistent congenital cytomegalovirus and toxoplasmosis in a newborn infant.


Bronchogenic carcinoma.

Bronchogenic carcinoma.


Oxidative haemolysis and Heinz body haemolytic anaemia.


Delayed incorporation of (75Se)selenomethionine into fibrinogen: its effect upon kinetic studies of fibrinogen with (75Se)selenomethionine in rabbits.


Neuromuscular blocking action of an alkylating local anaesthetic: site of action and effects of temperature and calcium ions.


Genetic complementation after fusion of Tay-Sachs and Sandhoff cells.


Solvent exposure of specific nuclei of angiotensin II determined by NMR solvent saturation method.


Analysis of specificity of antibodies contained in antiserum against poliovirus with mutants resistant to inhibitors in equine serum.


On-filter analysis of quartz in respirable coal dust by infrared absorption and X-ray diffraction.


Therapeutic action of antimicrobial agents in localized infections of mice.


Comparative evaluation of cyclacillin and ampicillin in urinary tract infections. A double-blind study.


Pre- and postoperative treatment of chronic multiresistant cases of pulmonary tuberculosis with rifampicin.


Atypical warts in cattle.

Atypical warts in cattle.


Biochemical characteristics of mammalian brain 5-hydroxytryptophan decarboxylase activity.


Ulcerative esophagitis associated with poxvirus infection in a calf.


Role of active transport of tryptophan in the control of 5-hydroxytryptamine biosynthesis.


On the effects of melatonin on sleep and behavior in man.


The role of serotonin in the regulation of a phasic event of rapid eye movement sleep: the ponto-geniculo-occipital wave.


Ventricular fluid 5-hydroxyindoleacetic acid concentrations during human sleep.


Effects of central alterations of serotoninergic neurons upon the sleep-waking cycle.


Opposite effects of serotonin and dopamine on copulatory activation in castrated male rats.


Melatonin: effects on brain function.

Melatonin: effects on brain function.


Serotonergic-dopaminergic interactions and extrapyramidal function.


Radioimmunoassay of porcine FSH.

Radioimmunoassay of porcine FSH.


The pathogenesis of recurrent infections with infectious bovine rhinotracheitis virus induced in calves by treatment with corticosteroids.


An outbreak of bovine cutaneous fibropapillomas following dehorning.


Americans love hogwash.

Americans love hogwash.


Megavitamin and orthomolecular therapy in psychiatry.


Radioiodine metabolism in endemic goitre in Nigeria. (Significance of the perchlorate discharge test).


Advantages of intertrochanteric osteotomy in osteoarthrosis of the hip.


Case report: pseudo-tumor of the liver in hepatitis.


The use of the Langner's Psychiatric Impairment Scale in a student health service.


Group after-care for employed problem drinkers.


Cosmetics: is new legislation needed?

Cosmetics: is new legislation needed?


Administrative relationships between maternal and child health programs and family planning programs in health departments--1973.


Cosmetics: marketing practices and the Federal Trade Commission.


Remarks on proposed cosmetic legislation pending in Congress.


Cosmetic legislation: the need.

Cosmetic legislation: the need.


Inactivation of poliovirus in water by ozonation.


Inhibition of replication of vesicular stomatitis virus in mouse embryonic cell culture infected with Japanese encephalitis virus.


A treatment for cold sores.

A treatment for cold sores.


Antiviral effect of 3, 4-dihydro-1-isoquinolineacetamide hydrochloride in experimental human rhinovirus infection. Double-blind trials were conducted in volunteers to evaluate the efficacy of the prophylactic 3,4-dihydro-1-isoquinolineacetamide hydrochloride (DIQA) treatment against rhinovirus type 24 challenge. Ten men received a 7-day course of DIQA treatment and 11 men received a placebo. The intranasal viral challenge dose was 10 mean tissue culture infective doses. The oral administration of 1 g prechallenge and 2 g a day for 6 consecutive postchallenge days did not prevent the development of colds. Nine drug-treated men and 10 controls developed rhinovirus illness. However, the illnesses of the drug-treated men were mild. Rhinorrhea occurred less frequently and was more mild in the drug-treated group. The challenge virus was recovered from 80% of these subjects in both groups, but almost twice the number of challenge viruses were isolated from the controls than from the drug-treated men. The prophylactic DIQA therapy appears to suppress the cold syndrome and to reduce virus excretion, although its effect is marginal. Additional clinical trials are warranted to confirm the antirhinoviral effect of this drug.


Review of the functional neuromuscular transmission unit.


Rehabilitation through team effort.

Rehabilitation through team effort.


Testosterone-activated copulatory behavior in the castrated male rat.


Fetal influences on myometrial contractility.


Embryonic antigen expression on experimental rat tumours.


Myasthenia gravis.

Myasthenia gravis.


Bronchogenic carcinoma in the presence of heart disease: a diagnostic dilemma.


Changes in 32P-content of phosphatidic acid and the phosphoinositides of rabbit platelets during aggregation induced by collagen or thrombin.


Histochemical findings on preleukemic states.


Nitroxides. 58. Structure of steroidal spin labels.


Ornithine decarboxylase turnover slowed by alpha-hydrazino-ornithine.


ACTH and alpha-MSH: cardiovascular and antiarrhythmic properties.


The influence of dichlorodiphenyltrichloroethane, polychlorinated biphenyls and anionic amphiphilic compounds on stabilization of sodium- and potassium-activated adenosine triphosphatases by acidic phospholipids.


Increasing the resistance of carp to dropsy by breeding. I. Methods of breeding for resistance.


Genetic control of the sensitivity of Aspergillus nidulans to mutagenic factors. II. The sensitivity of uvs mutants to different mutagenic factors.


5-Hydroxytryptamine and sleep in the cat: a brief overview.


Characteristics of a novel serum vitamin-B12-binding protein associated with hepatocellular carcinoma.


Proceedings: The release of plasminogen activator and factor VIII to lysine vasopressin, arginine vasopressin, I-desamino-8-d-arginine vasopressin, angiotensin and oxytocin in man.


Glucose intolerance in mice infected with encephalomyocarditis virus.


Steroid studies in a case of ovarian hyperluteinization with virilism in two consecutive pregnancies.


Growth of a new fiber projection in the brain of adult rats: Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions.


Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation.


Affinity chromatography of beta-hydroxybutyrate dehydrogenase on Nad and hydrophobic chain derivatives of sepharose.


Nine disease outbreaks associated with myxoviruses among ducks in Hong Kong.


Effects of phosphate on the dissociation and enzymic stability of rabbit muscle lactate dehydrogenase.


Covalent attachment of fluorescent groups to transfer ribonucleic acid. Reactions with 4-bromomethyl-7-methoxy-2-oxo-2H-benzopyran.


The vitamin-E-deficiency syndrome in pigs. 3. Light- and electron microscopic studies on myocardial vascular injuty.


Canary pox in sparrows and canaries (Fringillidae and in weavers (Ploceidae). Pathology and host specificity of the virus.


Cushing's syndrome secondary to ACTH-secreting Wilms' tumor.


Coenzyme contents of arterial tissue.

Coenzyme contents of arterial tissue.


Dissolution and removal of neuronal lipofuscin following dimethylaminoethyl p-chlorophenoxyacetate administration to guinea pigs.


IBR virus isolated from two epizootics in Mexican dairy cattle.


Food faddism.

Food faddism.


Letter: Ferroxidase I and II.

Letter: Ferroxidase I and II.


Swellings of the salivary glands. I. Non-neoplastic enlargements.


Investigation of some biochemical genetic markers in four endogamous groups in Panjab (N.W. India). II. Red cell enzyme polymorphisms.


The turnover rate of serum glycerides in the lipoproteins of fasting obese women during weight loss.


Aspects of experimental hepatocarcinogenesis. V. Ultrastructural morpholgy of early hepatocellular carcinomas.


Vascular problems in upper abdominal cancer surgery.


Primary liver tumors in infancy and childhood. 41 cases variously treated.


The Lockerbie road accident after-care scheme.


Bronchial carcinoma treated by adjuvant cancer chemotherapy.


Endocrine changes before and after the menarche. I. Urinary excretion of estrogen, FSH and LH, and serum levels of progesterone, FSH and LH.


Papaverine, a potent inhibitor of respiration in C-6 astrocytoma cells.


Enhancement of the activity of angiotensin II by certain cations.


Products, requirements and efficiency of biosynthesis: a quantitative approach.


Formation and biologic role of polyoma virus-antibody complexes. A critical role for complement. Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.


Expression of mammary tumor virus antigen on the membranes of lymphoid cells.


Inhibition of leukocyte migration by human tumors. Effect on patient survival.


Carcinogenic and hepatotoxic effects of diethylnitrosamine in hedgehogs.


Cancer control in Yugoslavia.

Cancer control in Yugoslavia.


Studies on the effect of fructose diphosphatase on phosphofructokinase.


Possible viral etiology of human cancer.


Differential effects of pentylenetetrazol on REM sleep in naive and cobalt-epileptic rats.


Cytoplasmic inclusions in urinary bladder epithelium of the rhesus monkey. A histochemical, light-and electron-microscopic study.


Proceedings: The role of choline in maintatining the fine structure of nerve terminals in the superior cervical ganglion of cat.


Protein and ribonucleic acid metabolism in single-cell suspensions from Morris hepatoma 5123tc and from normal rat liver.


Light and electron microscopic study of unfertilized egg of Ascidia malaca (Tunicata).


Availability of tryptophan to the brain and some hormonal and drug influences on it.


Intrahepatic arterial portal communications: angiographic study.


How important is the synthesis of brain 5-hydroxytryptamine in the physiological control of its central function?


Macro-regenerating nodule in the cirrhotic liver. Radiologic features and differential diagnosis.


Localized deformity of the gallbladder secondary to hepatic mass lesions.


Paralytic poliomyelitis in Ontario: laboratory studies of two recent cases. Sporadic cases of paralytic poliomyelitis are being reported with increasing frequency, particularly in unvaccinated persons, in several countries in which the disease had been absent for several years following adequate initial vaccination programmes. In Ontario, two paralytic cases occurred in unvaccinated children after several disease-free years. Detailed studies of the strains of poliovirus type 1 isolated from these patients showed that they were not vaccine strains. Contact surveillance in one case showed that 21 originally unvaccinated contacts were also excreting virulent virus.


Assay of variola virus on microtiter plates and its application to the neutralization test. It was established that microfocus assay of the variola virus in HeLa cell cultures on Microtiter plates is a suitable method for titrating the virus in numerous specimens of small volume. The variola foci were formed within 48 hours of inoculation, and the standard error for the number of foci per well did not exceed 15%, with 96 flat-bottomed wells (6 mm diameter) containing 0.1 ml per well of the culture media on a plastic plate replacing 96 Petri dishes in the standard assay procedures. Microfocus assay was successfully applied to the quantification of neutralizing antibody against variola and vaccinia viruses, with a reproducibility equal to that of the standard focus reduction method on glass Petri dishes. Applications of this technique to the assay of field specimens and to the laboratory differentiation of variola viruses are discussed.


Ecological studies on the mosquito vectors of Japanese encephalitis. These studies were conducted in China (Province of Taiwan) to assess the populations of known and potential mosquito vectors of Japanese encephalitis in a typical endemic area, and to evaluate a variety of sampling techniques, some of which were new. Culex annulus was found to be the predominant vector species in the study area during the epidemic season; C. tritaeniorhynchus was never abundant, and C. fuscocephalus was rare. C. annulus and C. tritaeniorhynchus were active throughout the year, although populations were at a low level during the cool season. The results show that attention must be given to C. annulus as a possible vector where it is present in JE foci. The collection of mosquitos during the early evening hours from buffalo bait tethered outdoors was found to be the most efficient and sensitive means of monitoring vector populations throughout the year. During the JE epidemic season remarkable results were obtained with a vacuum sweep-net.


Host-feeding patterns and behaviour of 4 Culex species in an endemic area of Japanese encephalitis. Studies were made on the host-feeding patterns and behaviour of 4 Culex species in China (Province of Taiwan) to further assess their importance as vectors of Japanese encephalitis. A relatively unbiased, non-attractant technique (vacuum sweep-net) was used for collecting mosquitos resting outdoors on rural premises; blood meals from engorged specimens were identified by precipitin tests. Additional information was obtained by analysing data from related studies. Precipitin-test results indicated that C. annulus, C. tritaeniorhynchus, and C. fuscocephalus feed principally on mammals, the first species mainly on swine and the latter two largely on bovine hosts. Mosquito forage ratios suggested that the apparent preference of C. annulus for swine over bovine hosts might be a function of host density. C. annulus was found to be zoophilic, exophilic, and exophagic; however, in view of its abundance during the JE epidemic season, contact with human hosts may reach a significant level, even indoors. The other 3 species of Culex were considered to be of lesser importance as JE vectors during the 1971 epidemic season because of their host-feeding patterns and/or population densities.


Association of the uterine 17beta-estradiol-receptor complex with ribonucleoprotein in vitro and in vivo.


Initiator methionine transfer ribonucleic acid from wheat embryo. Purification, properties, and partial nucleotide sequences.


Staphylococcal transfer ribonucleic acids. II. Sequence analysis of isoaccepting glycine transfer ribonucleic acids IA and IB from Staphylococcus epidermidis Texas 26.


Functional groups of diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Studies of cysteine residues.


Rotational and segmental motions in the lipids of human plasma lipoproteins.


Structure and methylation of coenzyme M(HSCH2CH2SO3).


Soluble cytochrome b-c1 complex and the reconstitution of succinate-cytochrome c reductase.


Physical and kinetic studies of arginyl transfer ribonucleic acid ligase of Neurospora. A sequential ordered mechanism.


Cyclic 3':5'-nucleotide phosphodiesterase. Purification, characterization, and active form of the protein activator from bovine brain.


Isolation and alignment of the tryptic peptides of alanine apolipoprotein, an apolipoprotein from human plasma very low density lipoproteins.


Phosphorylation of a cyclic adenosine 3':5'-monophosphate-dependent protein kinase from bovine cardiac muscle.


Aflatoxin hepatic carcinogenesis (sequential study in albino rats).


Microbial opportunism in clinical medicine.


The metabolism of vitamin D; recent developments and their clinical relevance.


Idiopathic thrombocytopenic purpura.

Idiopathic thrombocytopenic purpura.


Etiology and laboratory diagnosis of infectious mononucleosis: II. Cytomegalovirus (CMV) mononucleosis.


Etiology and laboratory diagnosis of infectious mononucleosis: I. Epstein-Barr virus (EBV) mononucleosis.


Classification and treatment of seizure disorders in children.


Foreign body granuloma of synovium following intra-articular injection.


Gout and pseudogout established by polarized light microscopy of synovial fluid. Methods and two case reports.


Histogenesis of prostatic carcinomas.

Histogenesis of prostatic carcinomas.


Cyclic changes in the uterine phosphatases during breeding and non-breeding seasons of Hemiechinus auritus collaris Gray, the Indian long-cared hedgehog.


Virus content of sewage in different seasons in Hungary.


Intraspecific variation in Plasmodium falciparum.


Malaria antibody levels in patients with Burkitt's lymphoma.


The interaction between Entamoeba histolytica and Trichuris muris infections in mice.


Susceptibility of Schistosoma mansoni from Liberia and Puerto Rico to antischistosomal drugs.


Ultrastructure of polymorphic Mucor as observed by means of freeze-etching. I. Vegetative growth of mycelium and arthrospore formation in submerged and aerated cultures.


The presence of unusual microtubular structures in senescent cells of Chlamydomonas dysosmos.


Treatment of Wilm's tumor. Diagnosis and surgical treatment.


Inorganic polyphosphates and enzymes of polyphosphate metabolism in the cellular slime mold Dictyostelium discoideum.


Cyanide-insensitive respiration in Moniliella tomentosa and the effect of drugs on respiration and polyol biosynthesis.


Treatment of Wilm's tumor. Radiotherapy.


Treatment of Wilm's tumor. Chemotherapy.


Cyclic nucleotide binding and protein kinase in the central nervous system of Galleria mellonella (L.).


Measured and calculated NAD+-NADH ratios in human erythrocytes.


Catabolite repression of L-arabinose isomerase in Escherichia coli induced by ultraviolet irradiation.


Turnover of hepatic mitochondrial ornithine aminotransferase and cytochrome oxidase using (14C)carbonate as tracer.


Hormonal regulation of collagen degradation in the uterus: inhibition of collagenase expression by progesterone and cyclic AMP.


Regulation of growth in vitro. I. Control of ornithine decarboxylase levels in untransformed and transformed mouse fibroblasts by serum.


Structural changes in rat liver endoplasmic reticulum following triiodothyronine administration.


Fluorescence and electron microscopical study of aminergic nuclei in the brain of Bufo poweri.


Origin and fate of the multivesicular bodies in PHA stimulated lymphocytes.


A quantitative study of the ultrastructural changes in the hypothalamo-neurohypophysial system during and after experimentally induced hypersecretion.


Structure and ultrastructure of the central nervous system of the polychaete Nephtys, with special reference to photoreceptor elements.


Cholinesterase in the posterior pituitary. Increased number of reactive pituicytes in the dehydrated rat.


Lipidosis-like alterations in hypothalamic neurosecretory cells of rats treated with chlorphentermine or iprindole.


Nerve endings in the arteria centralis retinae.


Investigations on the fine structure of Purkinje fibres in the atrium of the avian heart.


Ultrastructure of neurohemal organs (paraganglionic plates) of Trogulus nepaeformis (Scopoli) (Opiliones, Trogulidae) and release of neurosecretory material.


Ivestigations on adrenocortical mitochondria turnover. I. Effect of chronic treatment with ACTH on the size and number of rat zona fasciculata mitochondria.


Ultrastructure of mucosal mast cells in normal and compound 48-80-treated rats.


A modified thymol turbidity test in hyperglobulinaemia.


Anti-DNA virus activity of the 5'-nucleotide and 3',5'-cyclic nucleotide of 9-beta-D-arabinofuranosyladenine.


The use of density gradient centrifugation for the separation of serum lipoproteins.


The use of nitroblue tetrazolium prestaining of serum lipoproteins on polyacrylamide disc electrophoresis.


Hepatic hexokinase isozyme in liver diseases.


Possible association between an abnormal low density lipoprotein and nephropathy in lecithin: cholesterol acyltransferase deficiency.


Effect of Al-chlorophenoxyisobutyrate (Alufibrate) on pyruvate metabolism and on the fate of very low density lipoprotein lipids in hyperlipidemic patients.


A modified radiochemical assay for serum free fatty acid determination.


Effect of lipoic acid on tissue respiration in rabbits with experimental atherosclerosis.


Comparison of the frequencies of spontaneous and chemically-induced 5-bromodeoxyuridine-resistance mutations in wild-type and revertant BHK-21-13 cells. 5-bromodeoxyuridine resistance mutations induced by mutagenesis were studied. The average expression time for induced mutations varied with the concentration of the mutagen ethyl methanesulfonate (EMS). However, a constant number of two generation times was necessary for half maximal expression of induced mutations. Also, induced mutation rates were compared under optimal expression conditions for bromodeoxyuridine, fluorodeoxyuridine and azaguanine resistance markers. Ten independent bromodeoxy-uridine-resistant clones were tested for reversion. Two clones reverted-one spontaneously and the other after mutagenesis. The spontaneous rate of mutation to bromodeoxyuridine resistance, estimated by the fluctuation test, was high in revertant clones (4 x 10(-6) / cell / generation) and low in the wild-type cells (< 3.5 x 10(-8) / cell / generation). A comparison of induced mutation frequencies at variable EMS concentrations showed a single-hit curve for revertant clones and a multihit curve for the wild-type cells. Thymidine kinase activities of resistant clones were usually less than 2% of that of the wild-type clone. Inducibility, thermal stability and intracellular localization of the thymidine kinases of the wild-type cells and of a revertant clone were identical. A low, but significant (P < 0.10), Km discrepancy was observed between enzyme extracts of these lines. The genetic implications of these results are discussed.


Mutants of yeast defective in iso-1-cytochrome c. A medium containing chlorolactate has been devised to enrich for mutants that are unable to utilize lactate for growth, and therefore that may be defective in cytochrome c. Complementation tests of 6,520 chlorolactate-resistant mutants that were obtained spontaneously or induced with UV, ICR-170, or nitrosoimidazolidone resulted in the identification of 195 mutations at the cyc1 locus, which controls the primary structure of iso-1-cytochrome c. These 195 mutants, with 16 cyc1 mutants previously isolated, were examined for total cytochrome c by spectroscopic methods, growth on lactate medium, suppressibility by defined nonsense suppressors, mutational sites by x-ray-induced recombination, ability to revert, and in 86 cases, whether intragenic revertants contain altered iso-1-cytochrome c. Except for the deletion mutant cyc1-1, all of the mutants appeared to contain single-site mutations that could be assigned to at least 35 different sites within the gene. The cyc1 mutants either completely lacked iso-1-cytochrome c or contained iso-1- cytochromes c that were completely or partially nonfunctional. In spite of the fact that the cyc1 mutants obtained by the chlorolactate procedure were selected on the basis of defective function, 68% appeared to completely lack iso-1-cytochrome c. The remaining cyc1 mutants contained below normal amounts of iso-1-cytochromes c. Studies at several incubation temperatures indicated that these nonfunctional iso-1-cytochromes c were thermolabile. It is suggested that the predominant means for abolishing iso-1-cytochrome c by mutations are either through a complete loss, such as produced by chain terminating codons, or impairments through drastic changes of tertiary structure which lead to instability and thermolability.


Localization of 3', 5'-cyclic nucleotide phosphodiesterase activity in isolated thyroid cells and intact thyroid tissue.


An affinity column method for partial purification of cytochrome P-450 from phenobarbital-induced rabbit liver microsomes.


Reactivity of peptide imino groups in proteins with tert-butyl hypochlorite in relation to secondary structure.


Nuclear phosphoprotein kinases from rat liver.


Phosphodiesterase-phosphomonoesterases from Fusarium moniliforme. IV. Kinetic studies.


N-acyl specificity of Taka-N-acetyl-beta-d-glucosaminidase. IV. Essential requirement of the 2-acetamide-carbonyl group for the enzymatic hydrolysis.


Malignant fibrous histiocytoma and osteosarcoma in association with bone infarcts; report of four cases, two in caisson workers.


Effects of colchicine and vinblastine on the cellular action of vasopressin in mammalian kidney. A possible role of microtubules. To evaluate the possible role of microtubules in the cellular action of vasopressin on the mammalian kidney, the effects of microtubule-disrupting agents were studied in vivo and in vitro. In vivo studies were done in rats in mild to moderate water diuresis induced by drinking 5% glucose. Microtubule-disrupting alkaloids, colchicine (0.1 mg/day) or vinblastine (0.08 mg/day), given intraperitoneally, did not change water and solute excretion itself, but blocked or markedly inhibited the antidiuretic response (increase in urine osmolality and decrease in urine flow) to exogenous vasopressin. Total solute excretion was unaffected by these two alkaloids and there were no substantial changes in excretion of sodium, potassium, or creatinine. Lumicolchicine, a derivative of colchicine that does not interact with microtubules, did not alter the antidiuretic response to exogenous vasopressin. Activities of adenylate cyclase in the renal medullary plasma membrane, and cyclic AMP phosphodiesterase and protein kinase in renal medullary cytosol, were not influenced by 10(-5)-10(-4) M colchicine or vinblastine in vitro. Studies on the subcellular distribution of microtubular protein (assessed as [(3)H]colchicine-binding protein) in renal medulla shows that this protein is contained predominantly in the cytosol. Particulate fractions, including plasma membrane, contain only a minute amount (less than 6%) of the colchicine-binding activity. The results suggest that the integrity of cytoplasmic microtubules in cells of the distal nephron is required for the antidiuretic action of vasopressin, probably in the sites distal to cyclic AMP generation in the mammalian kidney.


Utilization of alpha-keto and alpha-hydroxy analogues of valine by the growing rat. When 70-80-g male albino rats eat a diet furnishing daily requirement of valine for optimal growth (70 mumol/g) and all other nutrients ("complete diet"), they gain weight at an average rate of 3.0 g/100 g body wt/day. When valine is removed, they lose weight at an average 2.1 g/100 g body wt/day. The growth retardation is improved or corrected by adding valine to the diet, daily weight gain being proportional to dietary valine content over a range of 0-70 mumol/g. Addition of alpha-ketoisovaleric acid instead of valine to the valine-free diet also improves or corrects the growth failure. Percent efficiency of alpha-ketoisovaleric acid as a substitute for valine was calculated as: 100 x (micromole valine per gram diet required to produce specified growth response)/(micromole alpha-ketoisovaleric acid per gram diet required to produce the same response). Efficiency of the substitution is inversely related to dietary content of the keto analogue, being 80% when diet contains 17.5 mumol/g (molar equivalent of (1/4) the daily requirement of valine), and 37% when diet provides 140 mumol/g (molar equivalent of twice the daily requirement of valine).alpha-Hydroxyisovaleric acid also substitutes for valine. Efficiency of the substitution at the single ration tested, 70 mumol/g diet, is 45%, similar to that for the keto analogue under the same conditions. When [1-(14)C]alpha-ketoisovaleric acid is injected intravenously, 30-80% of the administered radioactivity is exhaled as (14)CO(2) within 24 h. This finding suggests that inefficiency of alpha-ketoisovaleric acid as a substitute for valine results in part from degradation of the keto acid to isobutyric acid by branched chain dehydrogenase-decarboxylase. Oral administration of neomycin, polymyxin, and bacitracin reduces efficiency of alpha-ketoisovaleric acid as a substitute for valine by (1/4)-(1/2). This effect suggests that transamination of the keto acid may be performed in part by gastrointestinal microbes.


The turnover of cholesterol in human atherosclerotic arteries. The equilibration of cholesterol between plasma and atherosclerotic arteries was studied in 13 patients with obstructive atherosclerosis 2-96 days after the intravenous and/or oral administration of isotopic cholesterol. Arterial specimens were obtained in 12 patients during surgery for arterial reconstruction and in a 13th patient at autopsy. Equilibration was calculated as the specific radioactivity of cholesterol in the arterial tissue relative to that in the plasma (percent).In specimens obtained 2-4 days after pulse labeling, the specific activity of cholesterol in atheroma ranged from 0.3 to 4.5% of that in the plasma. By 17-27 days, the relative specific activity ranged from 6 to 20% in different arteries. In contrast, cholesterol of skeletal muscle had a relative specific activity of 96% by 22 days. By 61-96 days, atheroma cholesterol in the abdominal aorta, common iliac, and femoral arteries had equilibrated to 55, 30, and 26%, respectively. In the patient who died at 96 days, the cholesterol in the coronary arteries had a mean equilibration of 66%, similar to the values for the abdominal (66%) and thoracic (57%) aortas. The route of administration of the isotope did not influence the equilibration. Within the atheromatous plaque, the superficial layers equilibrated better than the deeper layers (75% vs. 22%). The free cholesterol in the atheroma equilibrated to a significantly higher extent than did esterified cholesterol (59% vs. 38%). There was a fourfold higher specific activity of cholesterol in the media than in the corresponding intima (916 vs. 230 dpm/mg). The estimated minimal influx rates of plasma cholesterol into the atheromatous intima ranged from 0.065 to 0.274 mg of cholesterol/g dry tissue per day for different arteries. The approximated turnover times of atheroma cholesterol ranged from 442 days for the abdominal aorta and the coronary arteries to 580 days for the common iliac and 821 and 934 days, respectively, for the femoral and the carotid arteries. These data indicate a definite, though slow, exchange of cholesterol between the plasma and severely atherosclerotic human arteries. Within the atheroma, there are multiple pools of cholesterol, each turning over differently and more slowly than the cholesterol of most other tissues, such as the skeletal muscle. The estimates of influx rate and turnover time of atheroma cholesterol suggest the possibility that this cholesterol is mobilizable, an indication of potential regression of atheromatous lesions in man.


Studies on locust neuromuscular physiology in relation to glutamic acid.


Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture. The prostaglandin (PG) content of mitogen- and antigen-stimulated leukocyte cultures was examined by a radioimmunoassay procedure empolying an antiserum reactive with PGB(1) and PGB(2), the alkaline dehydration products of PGE and PGA. At 48 h, mitogen-activated mouse spleen cell cultures showed 2-10-fold increases in the PGE, but not in the PGA, component of immunoreactive PG (iPG) fractionated by silicic acid column chromatography. Increases in iPG were detectable by h 16 in spleen cell cultures incubated with staphylococcal enterotoxin B. Since iPG levels rose only in the culture supernates and not in cells exposed to mitogens for 48 h, increases reflected extracellular release of PG. The validity of the radioimmunoassay determinations of PGE in spleen cell cultures was supported by the results of concomitant assessment of the PGE(2) content of basal and enterotoxin-stimulated cultures by gas chromatography/mass spectrometry. By the latter method, the PGE(2) content was three-fold higher in enterotoxin-activated, compared to basal, cultures at 48 h. Aspirin effectively suppressed increases in both iPG and PGE(2). In spleen cell cultures prepared from mice previously inoculated with an attenuated strain of yellow fever virus in vivo and then incubated with this virus in vitro, iPG levels increased twofold over basal at 48 h. By contrast, iPG content of spleen cell cultures prepared from saline-inoculated mice was not appreciably altered by exposure to the virus in vitro. The enhancement of iPG release from cultured spleen cells by mitogens did not correlate with an ability of these agents to increase cellular cyclic AMP (cAMP) levels. Moreover, epinephrine and cholera toxin markedly increased spleen cell cAMP content but had no demonstrable effect on basal iPG levels, suggesting iPG release from these cells was not mediated by cAMP. Incubation with mitogens also enhanced the iPG content of 72-cultures of human peripheral leukocytes and of human lymphocytes isolated by nylon chromatography. However, the iPG of cultures of human lymphocytes purified by glass bead chromatography and of mouse thymocytes was not appreciably altered when these cells were cultured with mitogens, even though DNA synthesis in both instances was markedly increased. Accordingly, iPG release was not an invariable concomitant of increased DNA synthesis in lymphoid cell cultures. In summary, the results demonstrate that mitogen and antigen stimulation of leukocytes in culture may be accompanied by enhanced release of PGE. The mechanisms mediating this phenomenon and its biologic significance remain to be delineated, but participation of PGE in immunologically induced inflammatory responses seems possible.


L-glutamate in arthropod blood plasma: physiological implications.


The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. The causes for the hypercalciuria and diagnostic criteria for the various forms of hypercalciuria were sought in 56 patients with hypercalcemia or nephrolithiasis (Ca stones), by a careful assessment of parathyroid function and calcium metabolism. A study protocol for the evaluation of hypercalciuria, based on a constant liquid synthetic diet, was developed. In 26 cases of primary hyperparathyroidism, characteristic features were: hypercalcemia, high urinary cyclic AMP (cAMP, 8.58+/-3.63 SD mumol/g creatinine; normal, 4.02+/-0.70 mumol/g creatinine), high immunoreactive serum parathyroid hormone (PTH), hypercalciuria, the urinary Ca exceeding absorbed Ca from intestinal tract (Ca(A)), high fasting urinary Ca (0.2 mg/mg creatinine or greater), and low bone density by (125)I photon absorption. The results suggest that hypercalciuria is partly secondary to an excessive skeletal resorption (resorptive hypercalciuria). The 22 cases with renal stones had normocalcemia, hypercalciuria, intestinal hyperabsorption of calcium, normal or low serum PTH and urinary cAMP, normal fasting urinary Ca, and normal bone density. Since their Ca(A) exceeded urinary Ca, the hypercalciuria probably resulted from an intestinal hyperabsorption of Ca (absorptive hypercalciuria). The primacy of intestinal Ca hyperabsorption was confirmed by responses to Ca load and deprivation under a metabolic dietary regimen. During a Ca load of 1,700 mg/day, there was an exaggerated increase in the renal excretion of Ca and a suppression of cAMP excretion. The urinary Ca of 453+/-154 SD mg/day was significantly higher than the control group's 211+/-42 mg/day. The urinary cAMP of 2.26+/-0.56 mumol/g creatinine was significantly lower than in the control group. In contrast, when the intestinal absorption of calcium was limited by cellulose phosphate, the hypercalciuria was corrected and the suppressed renal excretion of cAMP returned towards normal. Two cases with renal stones had normocalcemia, hypercalciuria, and high urinary cAMP or serum PTH. Since Ca(A) was less than urinary Ca, the hypercalciuria may have been secondary to an impaired renal tubular reabsorption of Ca (renal hypercalciuria). Six cases with renal stones had normal values of serum Ca, urinary Ca, urinary cAMP, and serum PTH (normocalciuric nephrolithiasis). Their Ca(A) exceeded urinary Ca, and fasting urinary Ca and bone density were normal. The results support the proposed mechanisms for the hypercalciuria and provide reliable diagnostic criteria for the various forms of hypercalciuria.


Saturday night retinopathy.

Saturday night retinopathy.


Paradoxical effects of d-amphetamine on behavioral thermoregulation: possible mediation by brain dopamine.


Effects of intracellularly applied cyclic 3',5'-adenosine monophosphate and dibutyryl cyclic 3',5'-adenosine monophosphate on the electrical activity of sinoatrial nodal cells of the rabbit.


Inhibition of angiotensin-induced adrenal catecholamine release by 8-substituted analogs of angiotensin II.


Influence of various substances which induce and inhibit aggregation on the uptake of deoxyglucose by human blood platelets.


Reliability of the RNA-DNA filter hybridization for the detection of oncornavirus-specific DNA sequences. Denatured DNA from leukemic myeloblasts or uninfected chicken embryos, immobilized on nitrocellulose filters, was hybridized to a vast excess of [(3)H]70S RNA from purified avian myeloblastosis virus. The viral RNA was eluted from the RNA-DNA hybrids, purified, and then rehybridized in solution to an excess of either leukemic or normal chicken embryonic DNA. This study revealed that all the slow and the fast hybridizing viral RNA sequences detectable by liquid hybridization in DNA excess had hybridized to the filter bound DNA. Both techniques also gave similar values for the number of 28S ribosomal RNA genes contained in a chicken cell genome: 210 by the liquid hybridization procedure and 218 by the filter hybridization technique. Therefore, filter hybridization can accurately detect DNA sequences present in relatively few numbers in the genome of higher organisms.


Cleavage of mengovirus polyproteins in vivo. The synthesis of mengovirus-specific proteins in vivo was studied by labeling the viral proteins with radioactive amino acids under conditions in which host protein synthesis was almost completely inhibited. Pulse-chase experiments enabled the kinetic analysis of the cleavages of certain viral protein precursors and the formation of others. The pattern of cleavages of mengovirus precursor polypeptides is similar to that of encephalomyocarditis virus. The major difference between the two viruses seems to be in the molar concentration in which the various primary products are produced. The molar ratio of the A protein, which is the precursor of the capsid proteins, to that of the primary products F and C, is approximately 1.5 to 2.0: 1: 1. Possible explanations for the unequal appearance of the structural and nonstructural proteins are discussed.


Selection of revertants of Kirsten sarcoma virus transformed nonproducer BALB-3T3 cells. Revertants of Kirsten sarcoma virus transformed nonproducer BALB/3T3 cells (KA31 cells) were isolated after exposing the transformed cells to 5-fluorodeoxyuridine at high cell density, or when suspended in methylcellulose. Revertants were also isolated by treating KA31 cells with the lectin, concanavalin A, which is manyfold more toxic to transformed cells than for normal cells. The revertants resemble BALB/3T3 cells in their morphology and growth characteristics in that they have a low saturation density, fail to grow in 1% calf serum or when suspended in methylcellulose, and cease to synthesize DNA after reaching their saturation density. Infection by murine leukemia virus rescues Kirsten sarcoma virus from only the concanavalin-A-selected variants, though all the revertants are susceptible to infection by leukemia virus. The concanavalin A revertants also become transformed after infection with murine leukemia virus. All the revertants can be transformed by Kirsten sarcoma virus but not by simian virus 40.


Sialoglycoprotein of vesicular stomatitis virus: role of the neuraminic acid in infection. Neuraminidase free of proteolytic activity substantially reduced the infectivity of vesicular stomatitis (VS) virus but less effectively than trypsin. The only sugar residue hydrolyzed by neuraminidase was N-acetyl neuraminic acid, approximately 89% of which was liberated from virion glycoprotein and the rest from virion glycolipid. Desialylation of virion glycoprotein but not of glycolipid resulted in progressive loss of infectivity. Sialyl transferase prepared and partially purified from BHK-21 cells catalyzed resialylation by CMP-[(14)C]sialic acid of the glycoprotein of neuraminidase-treated VS virions and supersialylation of unhydrolyzed VS viral glycoprotein. Resialylation of desialylated VS virions resulted in substantial (26-fold) restoration of their infectivity. We conclude that terminal neuraminic acids of VS viral sialoglycoprotein play an important role in initiation of infection with this virus.


Characterization of late polyoma mRNA.

Characterization of late polyoma mRNA. Polyoma-infected mouse kidney cell cultures were labeled with [(3)H]uridine for 3 h late in the lytic cycle (26 to 29 h after infection) and RNA was extracted from cytoplasm and nuclei and from isolated polyribosomes. Sedimentation velocity analysis in sucrose gradients showed that polyoma-specific "giant" and 26S RNAs are present exclusively in the nucleus. RNA associated with cytoplasmic polyribosomes was analyzed by sedimentation in aqueous sucrose density gradients and dimethylsulfoxide sucrose gradients, as well as by polyacrylamide gel electrophoresis. Polyoma-specific RNA in polyribosomes consists of at least two classes, with sedimentation coefficients of 16 (major fraction) and 19S (minor fraction) in aqueous sucrose gradients and 15 and 17S, respectively, in dimethylsulfoxide gradients. Estimates based on dimethylsulfoxide gradient and analysis suggest a molecular weight of approximately 500,000 for 16S RNA and 700,000 for 19S RNA. These polyoma RNAs seem to undergo reversible conformational changes under the different conditions of analysis. We cannot exclude the possibility that they contain more than one molecular species.


Characterization of the large picornaviral polypeptides produced in the presence of zinc ion. Zinc ion inhibits the posttranslational cleavages of human rhinovirus-1A, encephalomyocarditis virus, and poliovirus polypeptides. Each virus displayed a different susceptibility to zinc. However, in each case the cleavages of the capsid precursor and the cleavages analogous to the C --> D --> E conversion in encephalomyocarditis virus were most sensitive to zinc. Higher concentrations of zinc resulted in the buildup of even larger precursor polypeptides of a size between 106,000 and 214,000 daltons. The sizes of these polypeptides and the relative position of their gene loci on the viral RNA were determined. These data were used to place these polypeptides in the over-all scheme of viral protein processing.


Rhabdovirus replication in enucleated host cells. Infection of enucleated TC-7 monkey cells with rabies virus resulted in the synthesis of virus-directed RNA and the production of rabies antigens but not of infectious virus. The yield of infectious vesicular stomatitis virus from enucleated TC-7 cells, on the other hand, was almost as high as that from intact cells. Inhibition of the mitochondrial functions of enucleated cells by treatment with ethidium bromide did not influence the development of rabies antigens or the production of infectious vesicular stomatitis virus.


Transcriptional regulation of T4 bacteriophage-specific enzymes synthesized in vitro. In contrast to dihydrofolate reductase and four other phage-specific enzymes, the initiation of deoxynucleotide kinase is essentially prevented if rifampin is added to a culture of Escherichia coli B cells within 1.5 min after infection with T4. Deoxynucleotide kinase thus belongs to a group of so-called delayed-early enzymes that is not initiated from an immediate-early promoter site. We prepared crude extracts from infected cells in a manner designed to maintain the integrity of the complexes of native, endogenous T4 DNA with bacterial structural and enzymatic units concerned with RNA synthesis. The initiation of the synthesis of the mRNA for dihydrofolate reductase, an example of an immediate-early enzyme, and deoxynucleotide kinase, a special type of delayed-early enzyme, was studied with these extracts prepared from cells infected in the absence or presence of chloramphenicol. Initiation of transcription of the dihydrofolate reductase gene is immediate when programmed by extracts made either from cells treated with chloramphenicol prior to infection (CM extracts) or from cells 3 min into the normal infection cycle (3-min extracts). However, initiation of transcription of the deoxynucleotide kinase gene programmed by CM extracts is delayed 2 min relative to the immediate initiation of transcription of the deoxynucleotide kinase gene programmed by 3-min extracts. These experiments duplicated in vitro effects of the antibiotics on the synthesis of phage-specific mRNA previously noted only in vivo.


Growth in agarose of human cells infected with cytomegalovirus. After infection by human cytomegalovirus (CMV), human diploid fibroblasts could grow in agarose medium for several generations. Clones of infected cells grew for weeks, although in every case they ultimately underwent lysis owing to the cytopathic effect of the virus. Virus was inoculated at high dilution and after UV irradiation in an effort to derive cells infected with noninfectious defective particles still capable of inducing cell stimulation. Dilute or irradiated virus occasionally yielded large colonies of replicating cells, although permanent transformation was not observed. One clone derived from UV-CMV-infected cells was passaged four times before undergoing lysis. During these passages the cells exhibited alterations in morphology and orientation.


Improving emergency-room patient follow-up in a metropolitan teaching hospital. Effect of a follow-up check.


The renin-angiotensin system (first of two parts).


The preparation of brush border membranes from rat kidney using an aqueous two-phase polymer system.


A comparative study of two structurally related analogs of Asp1-Ile5-angiotensin II.


Relative contributions of Ca2+ influx and cellular Ca2+ release during drug induced activation of the rabbit aorta.


Platelet adenylate cyclase responses in depression: implications for a receptor defect.


Serum concentrations of beta-melanocyte-stimulating hormone in human pregnancy.


Study of serum lipid and blood fibrinolytic activity in cases of cerebral venous-venous sinus thrombosis during the puerperium.


Acute endogenous panophthalmitis caused by Clostridium perfringens.


Cell wall formation in zoospores of Allomyces arbuscula. I. Fine structural observations on encysting haploid zoospores.


Experimental vitreous surgery in monkeys. IX. Pars plana approach in open-sky technique.


Cornea and sclera.

Cornea and sclera.


The concept of social dominance.

The concept of social dominance.


Molecular modifications of anti-aldosterone compounds: effects on affinity of spirolactones for renal aldosterone receptors.


Effects of SC-26096(2-methyl-3-oxo-2azabicyclo(2.2.2.)octan-6-exo-yl 5-(4-biphenylyl)-3-methyl valerate), a new hypolipidemic agent, on mitochondrial respiration and oxidative phosphorylation.


Effects of opioid narcotic drugs on energy reserves of skeletal muscle. II. Further studies of the glycogenolytic action of methadone.


Further studies on the inhibition of drug metabolism by pregnanolone and related steroids.


A new phosphodiesterase inhibitor in human lymphocytes: N-methyl-isatin-beta-thiosemicarbazone.


Deoxythymidine triphosphate-deoxyuridine triphosphate nucleotidohydrolase induced by Bacillus subtilis bacteriophage phie.


The triplet state of reaction center bacteriochlorophyll: determination of a relative quantum yeild.


Biochemical and biophysical studies on cytochrome C oxidase. XIV. The reaction with cytochrome as studied by pulse radiolysis.


Biochemical and biophysical studies on cytochrome oxidase. XV. Reaction with fluoride.


Properties of the cytochrome a-like material developed in the photosynthetic bacterium Rhodopseudomonas spheroides when grown aerobically.


Light-induced absorbance changes in chloroplasts mediated by photosystem I and photosystem II at low temperature.


Characterization of a mutant of Schizosaccharomyces pombe lacking cytochrome b-566.


Oxidation of reduced nicotinamide-adenine dinucleotide by the malate-aspartate shuttle in Ehrlich ascites tumour cells.


Microbiological transformation of prostaglandins. II. Stereospecific reduction of A (plus or minus)-delta 8(12)-15-dehydroprostaglandin.


Metabolism of prostaglandin F2alpha in the rat.


Mechanism of biohydrogenation of cholesterol to coprostanol by Eubacterium ATCC 21408.


The distribution of molecular species of monoglycosylceramides (cerebrosides) in different parts of bovine digestive tract.


The acute action of adrenocorticotropic hormone on adrenal steroidogenesis.


On the solubility, stability and partial purification of CDPdiacyl-sn-glycerol: inositol transferase from rat brain.


Biochemical changes in Bifidobacterium bifidum var. Pennsylvanicus after cell wall inhibition. VII. Structure of the phosphogalactolipids.


Affinity chromatography of 3-oxosteroid delta4--delta5-isomerase of Pseudomonas testosteroni.


Sulfatides of hog gastric mucosa.

Sulfatides of hog gastric mucosa.


Microsomal synthesis of the ether analogs of triacylglycerols. Acyl CoA:alkylacylglycerol and acyl CoA:alk-i-enylacylglycerol acyltransferases in tumors and liver.


The effect of premixing on the oxidation of ethanol by liver alcohol dehydrogenase.


The inhibition of malate dehydrogenase by chlorammine-platinum complexes.


Lipoamide dehydrogenase of the phytopathogenic fungi Pythium ultimum and Phytophthora erythroseptica. Differences in conformation and kinetics.


Studies on glycogen synthase D phosphatase of rat liver--multiple nature.


Competition of inorganic pyrophosphate and a phosphomonoester as substrates for human placental alkaline orthophosphatase.


Solid-phase radioimmunoassay of rat skin collagenase. Comparative studies and in vivo measurement of the enzyme.


Separation of multiple dihydrotestosterone receptors in rat ventral prostate by a novel micromethod of electrofocusing. Blocking action of cyproterone acetate and uptake by nuclear chromatin.


The quaternary structure of lactate dehydrogenase. II. The mechanisms, kinetics and thermodynamics of dissociation, denaturation and hybridization in ethylene glycol.


Electron paramagnetic resonance studies on the copper(II) substituted alkaline phosphatase from Escherichia coli.


Two copper-containing proteins from cucumber (Cucumis sativus).


Histone and casein kinases of lactating bovine mammary gland.


Protein disposition in biological membranes.


The distribution of noradrenergic nerves and small, intensely fluorescent (SIF) cells in the cat urinary bladder. A light and electron microscope study.


Ultrastructural study of pigment cells of human red hair.


Ultrastructure of rat pituitary gonadotrophs following incubations of the gland with synthetic LH-RH.


The role of the nervous system in regeneration, growth and cell differentiation in Hydra. II. Ultrastructural study of nerve cell elements during hypostomal regeneration.


Electron microscopical and cytochemical study of vitelline cells in the fresh water triclad Dugesia lugubris s. 1. I. Origin and morphogenesis of cocoon-shell globules.


In vitro maturation of Arbacia punctulata oocytes and initiation of heavy body formation. An ultrastructural study.


Electrophoretic patterns of blood serum proteins of the cyprinid fish, Leuciscus leuciscus (L.).


Organophosphate splitting serum enzymes in different mammals.


Inhibition of the angiotensin I converting enzyme of the lung by a peptide fragment of bradykinin.


The effect of hydrocortisone on tension and cyclic AMP metabolism in tracheal smooth muscle.


Paracrystalline inclusions in mitochondria of frog oocytes.


Stimulation of cell aggregation by theophylline in the asexual reproduction of fresh-water sponges (Ephydatia fluviatilis).


Epstein-Barr virus-binding receptor on the surface of chronic lymphocytic leukaemic lymphocytes.


Cyclic guanosine 3',5'-monophosphate and gallbladder contraction.


Inherited hyperammonemic syndromes.

Inherited hyperammonemic syndromes.


Cross-reactions between human and animal plasma proteins. VI. An assay method for ape and monkey plasma proteins using antihuman antisera.


Metastasis of mammary carcinoma to the mandibular condyle.


Spontaneous conductance changes, multilevel conductance states and negative differential resistance in oxidized cholesterol black lipid membranes.


Localization of a calcium-stimulated ATPase in the basal-lateral plasma membranes of the proximal tubule of rat kidney cortex.


Polar lipid composition of the leaves and seeds from the tea plant (Camellia sinensis L).


To spritz or not to spritz: the doubtful value of aimless iontophoresis.


A 7S DNA polymerase in the cytoplasmic fraction from higher plant.


The role of the first component of the bovine complement system in the haemolytic activity of a bovine derived lytic intermediate.


Changes in electrolyte excretion following intraperitoneal injection of dibutyryl cyclic AMP in the brattleboro rat.


Renal effects of cyclic AMP in normal and congenital diabetes insipidus rats.


Virus-associated enzymes.

Virus-associated enzymes.


Kinetic and metabolic studies of Prostaglandin F2-alpha administered intra-amniotically for induction of abortion.


Decreased adrenal sensitivity to ACTH in the vasopressin-deficient (Brattleboro) rat.


Differential localization of the influence of lysine vasopressin and of ACTH 4-10 on avoidance behavior: a study in rats bearing lesions in the parafascicular nuclei.


Hypothalamic control of aldosterone production in sodium-deficient rats.


Brain monoamines and endocrine function.


Neuroendocrine transduction.

Neuroendocrine transduction.


Possible function of monoamines as neurotransmitters.


Possible sites of action of monoamines in hypothalamohypophyseal function.


Neuroendocrine transducer input-output relations.


Monoamines and control of glucocorticoid secretion from the adrenal cortex.


Gonad function and tuberoinfundibular dopamine.


Lesion effects on hypothalamohypophyseal function.


Brain monoamines and endocrine function. Conclusions.


A special baby visitor.

A special baby visitor.


Permeability and other properties of the outer mitochondrial membrane.


Antiviral activities of silver sulfadiazine in ocular infection.


"Cri du chat" syndrome with maternal insertional translocation.


'Stress' hormones and lipid metabolism.

'Stress' hormones and lipid metabolism.


Permeability of capillaries to different tracers and uptake of horseradish peroxidase by the secretory cells in rat anterior pituitary gland.


[Probable existence of hexosaminidase C locus located on chromosome 7 in man].


[Tissue culture of viruses (author's transl)].


A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.


A catch-up phenomenon in skeletal development of children with Down's syndrome.


A chromatographic method of assay of colchicine alkaloid.


A chickenpox epidemic in a pediatric burn unit.


A comparative histochemical study of some oxidative and hydrolytic enzymes in the kidneys of domestic food animals, laboratory animals and the fowl.


A comparison of graduate and recidivist WISC IQ scores in a delinquency treatment program for girls.


A comparative study of viruses associated with acute haemorrhagic conjunctivitis. Seven representative isolates from six outbreaks of acute haemorrhagic conjunctivitis were shown to have the characteristics of enteroviruses. Two viruses differed from the remaining five isolates in producing paralysis in suckling mice and being resistant to 2-hydroxybenzyl-benzimidazole. These two viruses were also closely related antigenically and distinct from the other five viruses which were serologically similar to each other. Neither group of viruses was inhibited by antisera to the known enteroviruses and they probably represent two new enterovirus types one related to the Coxsackie A viruses and the other to the echoviruses.


A comparison of urea and alkali degradation of full and empty bovine enterovirus particles.


A cytomegalovirus vaccine?

A cytomegalovirus vaccine?


A critical investigation into the antibiotic sterilization of heart valve homografts.


A deletion mutation placing the galactokinase gene of Escherichia coli under control of the biotin promoter. A deletion has been isolated which fuses galK and presumably galT to the promoter and operator of the bioA operon. The deletion has endpoints in bioA and galE, and leaves the operator-proximal end of bioA intact and the regulatory sites themselves functional. In bacterial strains which carry the deletion, the expression of galK is regulated by biotin, although due to the inefficiency of the bioA promoter even the fully derepressed level of galactokinase is low. Electron micrographic examination of the mutation shows that it is a simple deletion, uncomplicated by other chromosomal abnormalities.


A family study of 50 REM narcoleptics.

A family study of 50 REM narcoleptics.


A demonstration of several deoxyribonuclease activities in mammalian cell mitochondria. Extracts of purified mitochondria from adult rabbit liver and kidney have been prepared by lysis with Triton X-100. Such extracts contain deoxyribonuclease activity demonstrable at alkaline pH. Studies utilizing the effects of substrate variation, differing ionic strength, nucleoside di- and triphosphates, and SH-group inhibitors reveal the existence of at least five distinguishable deoxyribonuclease activities in these extracts. Assay of lysosomal and mitochondrial enzyme markers indicates no significant lysosomal contamination of the mitochondrial extracts. Further studies also suggest that the alkaline deoxyribonuclease activity is specifically located in or in association with mitochondria.


A filter assay for the sex steroid binding protein (SBP) of human serum.


A differential effect of chronically administered guanethidine on sympathetic neurotransmission to the dog heart and mesenteric arterial blood vessels.


A health and seroepidemiological survey of a community in Barbados.


A method for the implanation of solid and liquid materials in the marrow cavity of the femur of small laboratory animals.


A large hepatoma without apparent abnormality on laparotomy.


A modified tendon transference for radial nerve paralysis.


A modified two-dimensional gel system for the separation and radioautography of microgram amounts of ribosomal proteins.


A molecular theory of lipid-protein interactions in the plasma lipoproteins.


A new approach to the study of nucleotide sequences in DNA: the analysis of termini formed by DNases.


A new acid hydrolysis method for determining tryptophan in peptides and proteins.


A new assay of cyclic nucleotide phosphodiesterase; its application to human serum.


A new procedure for the two-dimensional display of the molecular size-electric charge characteristics of native proteins in crude mixtures.


A new purine ring closure and the synthesis of 2-substituted derivatives of adenosine cyclic 3',5'-phosphate.


A nuclear magnetic relaxation study of Co(II) bovine superoxide dismutase. Evidence that the Co(II) site is exchange-coupled to the copper and not accessible to the solvent.


A parasitological survey of a village in a mountain district of Papua.


A possible biological function of the protein kinase associated with vaccinia and vesicular stomatitis virions.


A probable mechanism for apurinic acid inhibition of DNA synthesis.


A pure sign of lumbrical function.

A pure sign of lumbrical function.


A quantitative approach to habituation and to evaluation of the effects of noisy neural pathways in a crayfish system.


A qualification to the use of TEA as a tracer for monosynaptic pathways.


A radioimmunoassay for serum dehydroepiandrosterone.


A rapid isolation of phosphoribosyladenosine triphosphate synthetase and comparison to native enzyme.


A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat. Bilateral lesions placed in the pontiene tegmentum resulted in episodes of paradoxical sleep in which the characteristic atonia of that sleep stage was absent in six cats. Following each period of synchronized sleep, in which the degree of muscle tone of the dorsal cervical muscles gradually diminished, cats with such lesions would slowly raise their heads, move their limbs at all joints, make several attempts to rise and eventually leap violently. During such episodes they were unresponsive to strong lights, touching and mild pinching. Only sound would arouse them. This behavior appeared as early as the 2nd postoperative day, the 1st day of recording. Such episodes supplanted normal paradoxical sleep with atonia and lasted unchanged for as long as 6 months in one cat until it was killed while still in good health. Complete recovery of atonia was observed in one cat after 3 weeks. Either no recovery or else eventual recovery to excessively active periods of paradoxical sleep while remaining recumbent characterized the sleep of the other four. The conclusion drawn from these experiments and from a review of the literature is that the hypotheses stating that the locus coeruleus or other isolated nuclei of the pons are specifically concerned with the initiation of paradoxical sleep are not clearly supported by available evidence.


A resolution of conflicting reports concerning the mode of action of fusidic acid.


A retrospective study of lung cancer in Bombay. This is a retrospective study of 520 patients with lung cancer, seen at the Tata Memorial Hospital between 1963 and 1970. Matched controls were obtained from those patients who came to the hospital within the same period and who were diagnosed as not having cancer. The patients and controls were matched for age, sex and community. As reported in other studies, an association was found between smoking habit and lung cancer. The relative risk of all types of smokers to non-smokers is 2·45, of bidi smokers 2·64 and of cigarette smokers 2·23. There is a preponderance of the group of epidermoid carcinomata among smokers as against adenocarcinomata. The probable reasons for the reported low incidence of lung cancer in this population have been discussed.


A role of the carbohydrate moiety of glucose oxidase: kinetic evidence for protection of the enzyme from thermal inactivation in the presence of sodium dodecyl sulfate.


A semi-automated in vitro assay for CRF: activities of peptides related to oxytocin and vasopressin.


A sensitive method for the detection of corticotrophin releasing factor using a perfused pituitary cell column.


A serologic study on cytomegalovirus infection associated with blood transfusion in Japanese.


A simple modification of the Tudor Thomas eye piece stand.


A simplified technique for hepatic resection: the crush method. A new technique of hepatic lobectomy with combined use of hepatic clamp and liver crush clamp is described. It is a simplification of the original finger fracture technique by using instruments instead of fingers for hepatic resection. It provides the unexperienced with a technique of hepatic resection done in the shortest possible time and in an almost bloodless field with safety. Since February 1973 the author has performed 5 hepatic resections with this crush method for primary liver cell carcinoma. The blood transfusion averaged 200 ml and the operation time averaged 1.5 hours. No complication or mortality was encountered and the patients were invariably discharged within 14 days after the operation.


A small portable centrifugal fast analyzer system.


A special program for nurse addicts.

A special program for nurse addicts.


A thermodynamic approach to the problem of stabilization of globular protein structure: a calorimetric study.


A spectrophotometric assay of beta-lactamase action on penicillins. A new method for measuring the enzymic hydrolysis of the beta-lactam ring in penicillins is described. The change in extinction in the u.v. region is determined. The method is sensitive (50mum-benzylpenicillin can be used) and convenient.


Abortive infection and transformation of human embryonic fibroblasts by Molluscum contagiosum virus.


A transmissible antigen detected in two cell lines derived from human tumours.


Acidic nuclear protein synthesis in Rous Sarcoma virus infected chick embryo fibroblasts.


Accumulation and metabolism of 3H-epinephrine by the rat heart during variable states of adrenocortical function.


Acceleration of sugar transport in avian erythrocytes by catecholamines.


Action of 'diamide' on some energy linked processes of rat liver mitochondria.


Action of cyclic 3',5' adenosine monophosphate on the uterus of the ovariectomized rat.


Activation by reductive cleavage of potentially cytotoxic azo compounds by human hepatocellular carcinoma.


Activation of cholesteryl esterase in bovine adrenal cortex.


Activation of latent collagenase by microbial plaque.


Activation of the peripheral lymphocytes in the course of the immune response to transplanted SV40-transformed tumour cells in hamsters.


Activation of transcription at specific promoters by glycerol.


Adenosine 3',5'-cyclic phosphorothioate: synthesis and biological properties.


Adenylate cyclase assay with adenylyl imidodiphosphate and product detection by competitive protein binding.


Adenyl cyclase and the cyclic AMP responsive systems in the uterus.


Adenovirus polypeptide synthesis in the presence of non-replicating poliovirus.


Adreno-leukodystrophy (sex-linked Schilder disease). Ultrastructural demonstration of specific cytoplasmic inclusions in the central nervous system.


Adrenocortical function following long-term corticosteroid treatment.


Adenocarcinoma of the larynx.

Adenocarcinoma of the larynx.


Adrenocortical function in the Burmese.

Adrenocortical function in the Burmese.


Adriamycin in advanced bronchogenic carcinoma.


Adult lipoid nephrosis: clinicopathological correlations.


Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary. The adrenocorticotrophic and melanocyte-stimulating peptides of the human pituitary were investigated by means of radioimmunoassay, bioassay and physicochemical procedures. Substantial amounts of adrenocorticotrophin and a peptide resembling beta-lipotrophin were identified in pituitary extracts, but alpha-melanocyte-stimulating hormone, beta-melanocyte-stimulating hormone and corticotrophin-like intermediate lobe peptide, which have been identified in the pars intermedia of pituitaries from other vertebrates, were not found. The absence of beta-melanocyte-stimulating hormone appears to contradict previous chemical and radioimmunological studies. Our results suggest, however, that it is not a natural pituitary peptide but an artefact formed by enzymic degradation of beta-lipotrophin during extraction.


Affinity chromatographic differentiation of lactate dehydrogenase isoenzymes on the basis of differential abortive complex formation.


Aerial applications of ultra-low-volume insecticides to control the vector of Japanese encephalitis in Korea. As a suitable emergency measure to arrest epidemics of Japanese encephalitis in Korea, the ultra-low-volume method of spraying insecticide to control the mosquito vector Culex tritaeniorhynchus has been tested in 2 successive years over a 16-km (2) area, utilizing a large fixed-wing aircraft. Malathion concentrate applied at 0.36 litres/ha gave insufficient control of the parous (infective) females, and no reduction in total numbers of this species. Fenitrothion concentrate applied at 0.45 litres/ha resulted in a 77-87% reduction in total numbers and an 87-98% reduction in parous females over a 4-day period.


Adrenal steroids in leukemia and lymphoma.


Affinity chromatography of cytosolic NAD-linked glycerol-3-phosphate dehydrogenase from normal and neoplastic mammalian tissues.


Aflatoxin hepatitis (an experimental comparative study).


Affinity labeling steroids for characterization of steroid binding sites.


Aldosterone production by adrenal cultures via dbcAMP, and the reversibility of ACTH and dbcAMP-induced changes.


Aggressive trends in endocrine surgery.

Aggressive trends in endocrine surgery.


Alleviation of barbiturate inhibition on the oxidative activity of submitochondrial particles by alkali.


Alkaline isomerization of ferricytochrome c: identification of the lysine ligand. Changes in the visible absorbance spectra of complexes of horse heart cytochrome c hemopeptide 1-65, peptide 66-104, and their guanidinated counterparts are compared with those characteristic of native and fully guanidinated ferricytochrome c over the pH range 7 to 11. Upon raising the pH, the methionine ligand in the guanidinated hemopeptide 1-65.peptide 66-104 complex is replaced by a strong field ligand. By contrast, the methionine ligand in the hemopeptide 1-65.guanidinated peptide 66-104 is replaced by a weak field ligand. These results demonstrate that lysine 13 does not ligate with the heme iron upon isomerization of ferricytochrome c and that the ligand in the horse heart protein is one of the eight lysine residues in the 66-104 segment of the polypeptide, most likely lysine 79.


Allyl alcohol-induced irreversible inhibition of yeast alcohol dehydrogenase.


Alteration of structure of level of threonyl-tRNA-synthetase in Borrelidin resistant mutants of E. coli.


Alveolar cell carcinoma (bronchiolar carcinoma).


An autopsy case of congenital hepatic cell tumor.


An epidemiologic and serologic comparison of uterine carcinoma in situ and squamous dysplasia.


An electron microscope study of mitochondrial DNA in spontaneous human tumours and chemically induced animal tumours. MtDNA was extracted by a phenol method from transplanted and primary DAB induced hepatomata in male Wistar rats, normal rat liver, spontaneous human tumours (2 Wilm's tumours, one neuroblastoma and one adrenal carcinoma), as well as 2 specimens of normal human kidney, BNU induced "leukaemias" in mice and CHO fibroblasts in monolayer culture. The proportion of monomers, catenated dimers and oligomers, open dimers and small circles was determined by electron microscopy of the fractions comprising lower and middle DNA bands in a CsCl-EthBr gradient. Tumours were compared where possible with their normal tissue of origin. Open dimers were found in 2 Wilm's tumours and their attached "normal-looking" kidney tissue but not in normal, non-malignant kidney or any other tissue studied. In Wilm's tumours, the occurrence of open dimers is far from being an all-or-none phenomenon. Malignancy produced little change in the relative proportions of catenated dimers and oligomers in the tissues studied. Small circles were found associated with mtDNA from every tissue. Tumour mtDNA was not more heterogeneous in length than monomers from the corresponding normal tissue, neither was the mean length of tumour mtDNA significantly different from its corresponding normal mtDNA.


An improved spectrophotometric assay for ribulosebisphosphate carboxylase.


An examination of the constancy of the rate of molecular evolution.


An in vitro study of mineralocorticoid binding proteins from rat kidney.


An inactivator for the affinity labelling of adenine nucleotide dependent enzymes.


An investigation of media for the long term storage of three respiratory viruses.


An unusual lipid-protein complex observed in an IgG myeloma patient.


Analysis of intact gangliosides by mass spectrometry. Comparison of different derivatives of a hematoside of a tumour and the major monosialoganglioside of brain.


Analysis of molecular species of 2H-labelled phosphatidylcholines by liquid-gel chromatography and gas chromatography-mass spectrometry.


Analysis of labeled 3' terminal nucleotides of DNA fragments.


Androgen transport and receptor mechanisms in testis and epididymis.


Analytical study of microsomes and isolated subcellular membranes from rat liver. IV. Biochemical, physical, and morphological modifications of microsomal components induced by digitonin, EDTA, and pyrophosphate. Isopycnic equilibration and sedimentation rate studies of rat liver microsomes led previously to the assignment of microsomal constituents into group a1 (monoamine oxidase), group a2 (5'-nucleotidase, alkaline phosphodiesterase I, alkaline phosphatase and cholesterol), group a3 (galactosyltransferase), group b (NADH cytochrome c reductase, NADPH cytochrome c reductase, aminopyrine demethylase, cytochrome b(5) and P 450), and group c (glucose 6-phosphatase, esterase, nucleoside diphosphatase, beta-glucuronidase and glucuronyltransferase). Confirmation and extension of the assignment into groups has been obtained by studying the differential effect of the reagents digitonin, EDTA, and PPi. Digitonin specifically affected the equilibrium density only of the group a2 and (to a lesser extent) group a3, and not of groups b and c under conditions which preserved the structure-linked latency of nucleoside diphosphatase and galactosyltransferase. Within experimental error the rate of sedimentation of all microsomal constituents was unaffected. The morphological appearance under the electron microscope was indistinguishable from that of nondigitonin-treated microsomes, except that a few smooth membranes (< 10%) exhibited broken-looking profiles. Treatment of microsomes with EDTA or PPi detached a substantial part of RNA and released protein in excess over the amount accountable for by detachment of ribosome constituents. This detachment was confirmed by electron microscopy. EDTA and PPi decreased markedly the equilibrium density and the density dispersion of groups b and c, due mainly to the uncoating of rough elements. EDTA and PPi shifted slightly the distribution profiles of groups a towards lower densities, possibly as a result of the release of adsorbed proteins. The combination of EDTA and digitonin, used subsequently, rendered the average equilibrium density of group a2 higher than that of groups b and c. Dense subfractions were thus enriched in constituents of group a2 and showed mainly broken-looking vesicles under the electron microscope. The import of our results on the biochemical and enzymic properties of the subcellular components of the microsome fractions is discussed.


An overview on new procedures in surgery of the hand.


Androgen-receptor cycling in prostate cells.


Androgens in the human fetus.

Androgens in the human fetus.


Androgens. I. A review of current research on the binding and mechanism of action of androgenic steroids, notably 5 alpha-dihydrotestosterone.


Animal DNA-dependent RNA polymerases. 10. General enzymatic properties of purified calf thymus RNA polymerases AI and B.


Anomeric specificity of enzymes of D-glucose metabolism.


Anterior hypophysial function in the posterior-hypophysectomized rat: normal regulation of the adrenal system.


Anti-allergic actions of disodium cromoglycate and other drugs known to inhibit cyclic 3',5'-nucleotide phosphodiesterase.


Antibodies to Epstein-Barr virus, cytomegalovirus, and Australia antigen in Hodgkin's disease.


Antiasthmatic drugs. II. Therapeutic aspects.


Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia.


Anticonvulsant activity and inhibition of respiration in rat brain homogenates by substituted oxadiazoles.


Antibody response of susceptible and resistant chickens (type-II leukosis) infected with JM and JM-V leukosis strains and herpesvirus of turkeys (HVT).