Synthesis of type 2 adenovirus DNA in the presence of cycloheximide. Adenovirus type 2 DNA synthesis, either in permissive human cells or nonpermissive monkey cells, becomes independent of protein synthesis after the appearance of progeny viral DNA. In the presence of cycloheximide, semiconservative replication and initiation of progeny molecules can occur.


Intracytoplasmic A particles: mouse mammary tumor virus nucleoprotein cores? A rapid method for the isolation of intracytoplasmic A particles, the putative intracellular nucleoprotein cores of mouse mammary tumor virus (MTV), is presented. Spontaneous C3H/He mouse mammary tumors and transplantable mouse Leydig cell tumor were used as source material. Large aggregations of intracytoplasmic A particles were separated from cellular contaminants on discontinuous sucrose gradients and subsequently further purified by isopycnic banding in linear sucrose gradients. The purified particles were solubilized in sodium dodecyl sulfate, and the structural proteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Purified mouse mammary tumor virions were solubilized, and their proteins were analyzed in the same way. Comparison of co-electrophoretic gels indicated a lack of correlation in the molecular size of the major structural proteins in intracytoplasmic A particles and MTV. The three major proteins of the A particles were calculated to be 80,000; 35,000; and 20,000 daltons. Five major polyacrylamide gel electrophoresis bands were obtained with purified MTV; these were 90,000; 69,000; 55,000; 37,000; and 27,500 daltons. These figures showed good correlation with those published for MTV by Nowinski et al. These results suggest the need for the reexamination of the current tenet that intracytoplasmic particles represent intracellular MTV nucleoprotein cores.


New intermediate subviral particles in the in vitro uncoating of reovirus virions by chymotrypsin. Reovirus virions, grown in suspension cultures of L cells and extensively purified by density gradient and velocity gradient centrifugation after their release from cell debris by fluorocarbon extraction, are characterized by a mean particle diameter of 73 nm and a density in CsCl of 1.36 to 1.37 g/cm(3). Treatment of intact virions by chymotrypsin (CHT) digestion in vitro converts them to subviral particles (SVP) having characteristics which are determined by the species of monovalent cation present during the digestion. In the presence of Cs(+) ions, CHT converts the virions to SVP of mean diameter 51 nm and density 1.43 to 1.44 g/cm(3). In the presence of K(+) ions, the conversion is to SVP of diameter 51 nm and density 1.39 to 1.40 g/cm(3). The SVP made in the presence of either Cs(+) or K(+) possess an extremely active RNA polymerase and nucleoside triphosphate phosphohydrolase (NTPase) activity in vitro and are resistant to further digestion by CHT. Treatment of intact virions with CHT in the presence of Na(+) or Li(+) ions results in their conversion to SVP of mean diameter 64 nm and density 1.37 to 1.38 g/cm(3). Such SVP are not active in in vitro RNA synthesis or NTP hydrolysis and are resistant to further digestion by CHT even during prolonged exposure to high concentrations of enzyme. Addition of Cs(+) or K(+) ions to the digestion mixture allows conversion of the 64-nm diameter SVP to 51-nm diameter SVP in which the RNA polymerase and NTPase are active in vitro. Analysis of the proteins present in intact virions and in the different SVP reveals clear differences which indicate that the conversions are accomplished by removal or cleavage of particular species of polypeptides.


Effect of isotopic label on buoyant density determinations of viral DNA in the preparative ultracentrifuge. The buoyant density of herpes simplex virus DNA may be significantly increased by isotopic labeling, particularly with (14)C. The apparent increase in buoyant density may be readily calculated from the specific activity of the DNA and is easily demonstrated by isopycnic centrifugation in both the preparative and analytical centrifuge.


Purification by oligo(dT)-cellulose of viral-specific RNA from sarcoma virus-transformed mammalian nonproducer cells. Viral-specific RNA has been purified by oligo(dT)-cellulose chromatography from sarcoma virus-transformed nonproducer cells. This RNA comprises approximately 3% of the purified RNA, as judged by RNA-DNA hybridization.


A genetic model of the host range restriction of murine leukemia viruses: a review and a hypothesis.


Purification of commercially available fluorescein isothiocyanate by silicic acid column chromatography.


Properties of a cytopathic agent isolated from a patient with subacute sclerosing panencephalitis in Japan.


Effect of dibutyryl cyclic AMP on nucleic acid and protein synthesis in neuronal and glial tumor cells.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23-1973.


Trigeminal neuralgia and herpesvirus.

Trigeminal neuralgia and herpesvirus.


Drug receptors and the haemopoietic stem cell.


Hyaluronate inhibition of chondrogenesis: antagonism of thyroxine, growth hormone, and calcitonin. The formation of cartilage-like aggregates in high-density stationary cultures of trypsinized chick embryo precartilage cells is blocked by low concentrations of hyaluronate. Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3',5'-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.


Cyclic AMP phosphodiesterase in cloned astrocytoma cells: norepinephrine induces a specific enzyme form. The soluble supernatant fraction of homogenates of cloned rat astrocytoma cells (linle C-2A) was subjected to polyacrylamide gel electrophoresis. Two peaks of adenosine 3',5'-monophosphate phosphodiesterase activity were found, corresponding to peaks I and IV of a similarly prepared homogenate of rat brain. Incubating cells with norepinephrine (0.3 mullimolar) caused about a threefold increase in the activity of peak IV but no change in peak I. This increase was completely inhibited by prior inclubation with propranolol (0.1 millimnolar), a beta-adrenergic blocking agent, or with cyclohexamnine (40 micromolar). a protein synthesis inhibitor. Induction of a specific phosphodiesterase form by norepinephrine sitggests another feedback control mechanism whereby an organism can prevent the effects of excessive sympathetic activity.


Leukemia virus activation during homograft rejection. Activation of murine leukemia viruses, as detected by the mixed culture cytopathogenicity (XC) assay, followed the transplantation of A/J skin onto immunosuppressed BALB/c mice. Virus was found in most of the mice receiving both skin grafts and antilymphocyte serum, but not in animals receiving either the serum alone, skin graft alone, or no treatment.


Octopamine-sensitive adenylate cyclse: evidence for a biological role of octopamine in nervous tissue. An adenylate cyclase that is activated specifically by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system. This enzyme appears to be distinct from two other adenylate cyclases present in the same tissue, which are activated by dopamine and by 5-hydroxytryptamine, respectively. The data raise the possibility of a role of octopamine-sensitive adenylate cyclase in the physiology of synaptic transmission.


Genetic mapping of the Fv-1 lcous of the mouse. The Fv-l locus of the mouse, a major determinant of the biology of murine leukemia virus, is very closely linked to Gpd-1 on chromosome 4 (linkage group VIII).


Cholesterol content and phospholipid composition of Morris hepatoma microsomes.


Height and weight of United States children: second report.


Gangliosidosis with total hexosaminidase deficiency: clinical, biochemical and ultrastructural studies and comparison with conventional cases of Tay-Sachs disease.


Control of vasopressin stimulation of sodium transport in the toad bladder.


Response of frog muscle spindle system to whole-muscle input parameters.


Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate.


Angiotensin I conversion in the kidney and its modulation by sodium balance.


Extra-adrenal effect of ACTH on fibrinogen synthesis.


Influence of hypophysectomy and training on size of isolated fat cells.


GABA-transaminase inhibitors and presynaptic inhibition in the amphibian spinal cord.


Angiotensin, vasopressin, and cyclic AMP: effects on sodium and water fluxes in rat colon.


Research utilization, a problem in goal setting: what is the question?


Premorbid adjustment, paranoid diagnosis, and remission. Acute schizophrenics treated in a community mental health center.


Electrical activity in neocortical projection and association areas during slow wave sleep.


Production of histamine-like and prostaglandin-like substances from serum incubated with rat, dog, mouse or human tumours.


The prevention and treatment of varicella-zoster infection in patients at high risk.


Control by TSH of a phospholipase A 2  activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid.


On the subunit structure of cytochrome oxidase from beef heart mitochondria.


Hydrolysis of sphingomyelin liposomes by sphingomyelinase.


Conformational differences in the myosin-ADP complex in myofibrils and isolated myosin.


Oxytocin receptor in frog bladder epithelial cells. Relationship of ( 3 H)oxytocin binding to adenylate cyclase activation.


On the regulatory properties of a halophilic citrate synthase.


Ethanol-induced fatty liver: effect of intestinal lymph fistula.


Facial nerve preservation in relation to tumour size in acoustic nerve tumour surgery.


Optokinetic nystagmus in diseases of the central nervous system.


Renal renin in experimental nephrosclerosis.


Causes of elevated perilymph protein concentrations.


Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP.


Thymus and bone marrow derived lymphatic leukaemia in mice.


Cholera enterotoxin: failure of anti-inflammatory agents to prevent cyclic AMP accumulation.


SV40 protection in myeloma oncogenesis.

SV40 protection in myeloma oncogenesis.


Transfer RNA activities of Rous sarcoma and Rous associated viruses.


Specificity in initiation of protein synthesis in a fractionated mammalian cell-free system.


Satellite DNA replication in baby mouse kidney cells infected with polyoma virus.


F1-histone phosphorylation in metaphase chromosomes of cultured Chinese hamster cells.


Glucocorticoid binding proteins in human leukaemic lymphoblasts.


Periodic breathing in premature and neonatal babies: incidence, breathing pattern, respiratory gas tensions, response to changes in the composition of ambient air.


Studies on ciliary dyskinesia factor in cystic fibrosis. II. Short term leukocyte cultures and long term lymphoid lines.


Poly(adenosine diphosphate ribose).

Poly(adenosine diphosphate ribose).


Calcification in a gastric mucinous adenocarcinoma.


Preparative-scale synthesis of (1R)-and (1S)-monodeuteriopropanol by enzymatic exchange reactions.


Isolation of DNA and DNA polymerase from MC 29  tumor virus.


Radioisotope brain scans in the diagnosis of brain tumors: technic and applications. With emphasis on recognition of lesions outside of the posterior fossa.


Immunological relationship of Brucella with microorganisms of other genera.


A poxvirus isolated from silvereyes (Zosterops lateralis) from Lower Hutt, New Zealand.


The secretion of dehydroepiandrosterone and dehydroepiandrosterone sulphate in man.


Herpesvirus infection in the black rat (Rattus rattus).


Stimulation of endogenous respiration of ejaculated ram sperm by dibutyryl cyclic AMP.


Stimulation of division of density inhibited fibroblasts by glucocorticoids.


Implications of chemoautotrophism in Mycobacterium leprae.


Poly (A) and poly (U) in poliovirus double stranded RNA.


Factor in acidified serum toxic for malignant cells in culture.


Collagenase inhibition with penicillamine. Case report.


Surgical decisions in the treatment of major salivary gland tumors.


Effect of 3,7-dimethyl-1-(5-oxo-hexyl)xanthine and 1-hexyl-3,7-dimethyl xanthine on cyclic AMP phosphodiesterase of the human umbilical cord vessels.


Treatment of bilateral breast carcinomas in a patient with silicone-gel breast implants. Case report.


A comparison of the effects of methyl methanesulfonate in various reproductive toxicity screening tests.


Apparent suppression of the tumorigenicity of human cancer cells by cyclic AMP.


Actions of lithium on cerebral carbohydrate metabolism.


Retinal anlage tumour. A case report.

Retinal anlage tumour. A case report.


Genetics of hyperlipidemia in coronary heart disease.


Nature of defect responsible for familial vitamin D-resistant rickets (VDRR) based on radioimmunoassay for parathyroid hormone (PTH).


In vitro demonstration of iodide-trapping defect but normal thyrotropin (TSH) responsiveness in benign and malignant "cold" thyroid nodules.


The syndrome of hypertension, hyperreninemia and secondary aldosteronism associated with renal juxtaglomerular cell tumor (primary reninism).


Clinical experiences with tumours of the lacrimal gland.


Pathology of some lacrimal gland tumours.


Studies on biosynthesis of polymyxin E (colistin). II. Biosynthesis of polymyxin E by mutants m-5 and d-13 of Bacillus polymyxa K-1.


A new approach to hyperlipoproteinemia phenotyping.


Experimental herpes simplex encephalitis. Treatment with pyrimidine nucleosides.


Clarification of some basic vocabulary: terminology today.


Motor nerve terminal and muscle membrane stabilization by diphenylhydantoin administration.


Cerebral arterial spasm. Modification by inhibition of platelet function.


Herpetic meningitis (type 1) in a case of acute leukemia.


Spinal ganglion in herpes zoster. A light and electron microscopic study.


Genetics and colon cancer.

Genetics and colon cancer.


The glycosaminoglycans of articular cartilage in calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (chondrocalcinosis articularis or pyrophosphate arthropathy).


Subcellular fractionation of the enterocyte with special reference to peptide hydrolases.


Comparison of steroidogenic effects of cAMP and dbcAMP in the rat adrenal gland.


Evidence for a role of adenosine 3',5'-monophosphate in parathyroid hormone release.


Cyclic 3'5'-adenosine monophosphate in isolated bone cells. Response to low concentrations of parathyroid hormone.


On the mechanism of action of luteinizing hormone-releasing factor and prolactin release inhibiting factor.


Regional responses of the pituitary to corticotropin-releasing factor (CRF) and ammonium ions.


Biologic action of 1,25-dihydroxy-vitamin D3 in the rachitic dog.


Effects of some modifiers of insulin secretion on insulin biosynthesis.


Effects of calcium and theophylline on ACTH- and dibutyryl cyclic AMP-stimulated steroidogenesis and glycolysis by intact mouse adrenal glands in vitro.


Luteinization of transplanted ovarian follicles in the rat induced by dibutyryl cyclic AMP.


Lack of specificity for the extra-ovarian prolactin effect on vaginal mucification in rats.


The subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions.


Luminescence quenching in azurin.

Luminescence quenching in azurin.


Spin-labelled phosphofructokinase and its interactions with ATP and metal-ATP complexes as studied by magnetic-resonance methods.


Transport of lactate and succinate by membrane vesicles of Escherichia coli, Bacillus subtilis and a pseudomonas species.


Diacetyl (acetoin) reductase from Aerobacter aerogenes. Kinetic studies of the reduction of diacetyl to acetoin.


Isolation of viruses, bacteria and other organisms from venereal disease clinic patients: methodology and problems associated with multiple isolations.


Serum lipoproteins of normal and cholesterol-fed rats. The density distribution of lipoproteins in rats fed chow or chow containing 1% cholesterol and 10% olive oil was studied. Lipoprotein fractions were prepared in the ultra-centrifuge between narrow density bands within the density range of 1.006-1.21 and were analyzed by chemical, electrophoretic, and immunological methods. In serum from normal rats there were three major lipoprotein fractions, with densities less than 1.006, 1.030-1.063, and 1.063-1.21. Almost no lipoprotein was found between d 1.006 and 1.030. Most of the low density lipoprotein appeared between a density of 1.04 and 1.05. In the density range 1.05-1.07, small amounts of both low density and high density lipoprotein were found. Feeding a diet high in cholesterol resulted in a marked increase in the concentration of lipoproteins of density less than 1.006, and a new lipoprotein fraction appeared between d 1.006 and 1.030; this fraction contained immunologically demonstrable low density and high density lipoproteins. In addition, there was a decrease in the high density lipoprotein fraction between d 1.070 and 1.21.


Early changes in plasma lipoprotein structure and biosynthesis in cholesterol-fed rabbits. Plasma lipoproteins of d < 1.063 g/ml from rabbits fed a diet containing 1% cholesterol for 4 days showed changes in concentration and rates of flotation as determined by analytical ultracentrifugation. A marked increase in cholesteryl ester content of lipoprotein with d < 1.019 g/ml was the most prominent change in rabbits fed the diet for 21 days. Gel electrophoresis and immunochemical procedures demonstrated that in control and hypercholesterolemic rabbits there were some common apolipoproteins found in all lipoproteins with density < 1.063 g/ml. In control rabbits, there were also apolipoproteins specific to the lipoprotein fraction with d < 1.019 and to the fraction with d 1.019-1.063 g/ml. However, in rabbits fed the hypercholesterolemic diet for 21 days, the apolipoproteins characteristic of fraction 1.019-1.063 were the most abundant in the fraction with d < 1.019 g/ml. Liver slices from rabbits fed the high cholesterol diet for 7 and 21 days incorporated more l-[(14)C]leucine into very low density and low density lipoproteins than controls. The results suggest that cholesterol feeding leads to an increase in biosynthesis of lipoproteins with d < 1.063 g/ml. The newly synthesized lipoprotein contains apolipoproteins similar to those found in controls but with a higher lipid-to-protein ratio. From the apoprotein composition, it is concluded that the very low density fraction present in cholesterol-fed animals is more structurally related to low density lipoproteins than to the very low density lipoproteins isolated from control animals.


Identification of mountebank healing artists.


Effects of ethanol on the metabolism of free fatty acids in isolated liver cells. Ethanol inhibited the oxidation and enhanced the esterification of albumin-bound [1-(14)C]palmitate incubated with isolated rat liver cells. Ethanol decreased the conversion of [1-(14)C]palmitate to (14)CO(2) and (14)C-labeled ketone bodies and enhanced the incorporation of [1-(14)C]palmitate into glycerolipids, especially triglyceride; cholesteryl ester synthesis was unaffected. The half-maximal effective ethanol concentration for each of these processes was 6-10 micro g/ml and a maximum effect was produced by about 50 micro g/ml. Ethanol oxidation was required for each of these alterations, since the effects were completely abolished by pyrazole. The energy obtainable from ethanol oxidation was in excess of the energy deficit from decreased fatty acid oxidation. However, ethanol did not affect O(2) consumption, indicating that ethanol oxidation replaced the oxidation of both fatty acids and other substrates. Ethanol inhibited the citric acid cycle in the intact liver cells by 20-30%. The major site of inhibition was alpha-ketoglutarate oxidation. Results suggest that ethanol inhibited alpha-ketoglutarate dehydrogenase in the mitochondria of hepatocytes by elevating the mitochondrial NADH:NAD ratio. A minor site of inhibition of ethanol oxidation was detected between succinate and citrate. It is suggested that ethanol inhibits fatty acid oxidation in hepatocytes by competitive substrate oxidation, resulting in an increased availability of long-chain free fatty acids; this thereby enhances esterification, leading to accumulation of liver triglyceride.


Human tumours grown in mice.

Human tumours grown in mice.


Forssman reactivity and cell contacts in cultured hamster cells.


Effects of cytochrome c on liver functions of old rats.


Polymorphism of natural DNA.

Polymorphism of natural DNA.


Regulation of phospho-enol-pyruvate carboxykinase during starvation and glucose repression.


Inhibition of adenovirus type 12 induced DNA synthesis in G1-arrested BHK21 cells by dibutyryl adenosine cyclic 3':5'-monophosphate.


Growth control and cyclic alterations of cyclic AMP in the cell cycle.


Cell line derived from Balb-3T3 that is transformed by murine leukaemia virus: a focus assay for leukaemia virus.


Inhibition of MLV-induced transformation in Balb-3T3 derived cells.


Sub-clinical involvement of peripheral nerves in Hodgkin's disease.


The incidence and significance of Australia antigen in cancer patients.


Stimulation and retardation of limb regeneration by adenosine 3',5'-monophosphate and related compounds.


The neurophysiologic basis of pain.

The neurophysiologic basis of pain.


Fundamental considerations of chronic pain therapy.


Chemodectomas of the head and neck.

Chemodectomas of the head and neck.


Cytomegalic inclusion disease. Report of a case diagnosed radiologically.


The Tecumseh study of respiratory illness. V. Patterns of infection with the parainfluenzaviruses.


The epidemiology of hepatitis B antigen in a high prevalence area.


A seroepidemiological study of Epstein-Barr virus and other viral antigens in sarcoidosis.


Stimulation of granulation tissue growth in burns.


A mathematical evaluation of tumour growth curves in rapid, intermediate and slow growing rat hepatomata.


Conformational and biological properties of partial sequences of glucagon.


Expectancy and the pituitary-adrenal system.


Coexistent herpes simplex encephalitis and malignant astrocytoma. A clinicopathologic study of three cases.


Immunoglobulins and EB virus antibodies in infectious mononucleosis.


Serum autoantibodies in hepatitis associated antigen (HAA) positive patients. A possible index of cell-mediated immunity to the associated-infective agent.


Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia.


Enzymic degradation of cartilage in osteoarthritis.


Selective media in the isolation of tubercle bacilli from tissues. Direct culture on Lowenstein-Jensen slopes and on three media made selective for tubercle bacilli by the addition of four antibacterial agents was compared with guinea-pig inoculation on 490 tissue specimens. Tubercle bacilli were obtained from 15 specimens by culture and 14 by guinea-pig inoculation; only one specimen was positive by guinea-pig and not by culture. The most efficient culture medium was a selective 7H11 slope. Routine guinea-pig inoculation has been replaced by a wider range of culture procedures.


A comparative study of five laboratory tests for foeto-placental dysfunction in late pregnancy. Five foeto-placental function tests were studied in parallel in normal and abnormal late pregnancies with a view to establishing which test or tests is most satisfactorily able to identify the mother whose foetus is in danger.A critical examination of the levels in blood serum of two enzymes, placental phosphatase isoenzyme and cystine aminopeptidase, the polypeptide hormone placental lactogen (chorionic somatomammotrophin), and the oestrogen oestriol-17beta is described.A correlation was attempted beween clinical data and the results of the above laboratory analyses and also with the daily urine oestrogen output. The plasma and urine oestriol levels proved generally to be the more useful warning tests in late pregnancy, whilst the plasma cystine aminopeptidase was the least sensitive indicator of foeto-placental dysfunction.


Distribution of  14 C-isoxazole in adrenals, ovaries, and breast carcinoma.


Caval-portal shunting as a cause of a focal increase in radiocolloid uptake in normal livers.


Localization of  99m Tc in the choroid plexus of the fourth ventricle.


Evidence for naturally occurring murine sarcoma virus.


Puromycin stimulation of rat liver ornithine decarboxylase activity.


Concentration of selected intravenously administered antibiotics in experimental surgical wounds.


Prostaglandin E2: effects on aggregation, shape change and cyclic AMP of rat platelets.


Effects of a prostaglandin antagonist, polyphloretin phosphate, on basal and stimulated thyroid function.


Properties of 15-hydroxy prostaglandin dehydrogenase: structural requirements for substrate binding.


Reversibility of 15-OH prostaglandin dehydrogenase from swine lung.


Radioimmunoassay of prostaglandins, angiotensin, digoxin, morphine and adenosine-3',5'-cyclic-monophosphate with nitrocellulose membranes.


Resection of the inferior vena cava for adjacent malignant diseases.


Pitfalls of local excision in the treatment of carcinoma of the breast.


Long term survivors after resection of bronchial carcinoma.


Summary of recent abstracts. II. Amoebiasis and intestinal protozoal infections.


A therapeutic aftercare setting for "refractory" chronic schizophrenic patients.


Proteoglycans-collagen interactions in human costal cartilage.


Primary structure of cytochrome c from the emu, Dromaeus novaehollandiae.


Cyclic adenosine monophosphate and cardiac contractility.


Isolation and identification of phospholipids from root tip cell plasmalemma of Phaseolus limensis.


Substrate requirements for angiotensin I conversion in vivo and in vitro.


Comparative studies on the effects of aminoglutethimide, metopirone, ACTH and hydrocortisone on the adrenal cortex of adult male rats. II. Histological and histochemical studies.


Effect of angiotensin on water and electrolyte excretion in normal and cirrhotic rats.


Histochemical alterations in tissue culture produced by enteroviruses.


Cytomegalovirus infection of two neonates with evidence of lympho-proliferation.


Inhibition of macrophage migration by a proteoglycan extracted from Kurloff cells of the guinea-pig.


Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus. Infection of DBA/2N male mice with encephalomyocarditis virus resulted in a diabeteslike syndrome characterized by hyperglycemia, glycosuria, hypoinsulinemia, polydipsia, and polyphagia. Blood glucose levels were elevated within 4 days after infection and reached a maximum mean level of 320 mg/100 ml within 12 days. Approximately 60-80% of the animals developed a transient hyperglycemia while 10-15% of the animals remained hyperglycemic for well over 6 mo. The remaining animals failed to become hyperglycemic but many had abnormal glucose tolerance curves. Hyperglycemia was most pronounced when animals were allowed free access to food, and the incidence of byperglycemia was related both to the strain and sex of the animals, with few females developing hyperglycemia. The amount of immunoreactive insulin in the plasma of infected hyperglycemic mice was significantly lower than in appropriate controls, and injection of exogenous insulin resulted in a rapid drop in the blood glucose levels. Despite the fact that certain animals were hyperglycemic for many months, virus could not be recovered from the pancreas after the first 10 days of the infection.


Studies on polynucleotides. CXVI. A further study of the T4 ligase-catalyzed joining of DNA at base-paired ends.


The influence of the partner cell on the production of L virus and the expression of viral surface antigen in hybrid cells. The C-type particles produced by the A9 and A9HT sublines of mouse L cells were shown to infect C3H (N type), but not C57BL (B type), mouse embryo fibroblasts. Infection was indicated by distinct single giant cell formation in the XC monolayer used to overlay the mouse embryo fibroblasts. On the basis of these results it was concluded that the L cell virus is N tropic. A9 and A9HT cells were fused to various mouse cells derived from tumors and normal tissues. The ability to produce the Moloney-type surface antigen and to release infectious virus was introduced by the A9 component into the hybrid cell. Virus production, measured by antigen induction on JLS-V9 cells, was suppressed in those hybrids in which the partner cell had a genotype determining low infectibility with that particular virus (B-type cell). It thus appears that the major genetic locus affecting resistance to infection with leukemia viruses, the Fv-1 locus, regulates infectious virus production in somatic cell hybrids also. The same genetic locus did not seem to govern the expression of all virus-related functions, for the virus-determined membrane antigen was demonstrated in many of the N x B-type hybrids in which production of infectious virus was suppressed.


Replication of polyoma DNA in isolated nuclei. I. Characterization of the system from mouse fibroblast 3T6 cells.


Replication of polyoma DNA in isolated nuclei. II. Evidence for semi-conservative replication.


Polypeptide conformation of cytoplasmic malate dehydrogenase from an electron density map at 3.0 angstrom resolution.


Regulation of skeletal muscle contraction. II. Structural studies of the interaction of the tropomyosin-troponin complex with actin.


Isolation and some distinctive properties of a new type of recombination-deficient mutant of Bacillus subtilis.


Antigen expression and colony formation of lymphoblastoid cell lines after superinfection with Epstein-Barr virus.


DNA polymerase activity and DNA synthesis in preneoplastic nodule outgrowths of BALB-c and C3H mouse mammary gland.


Production and characterization of human cell-adapted murine Rauscher virus pseudotype of murine sarcoma virus.


Induction of bladder cancer in hamsters by repeated intratracheal administrations of 2-acetylaminofluorene.


Comparative studies on Visna, progressive pneumonia, and Rous sarcoma viruses by electron microscopy.


Occurrence of a primary liver carcinoma in a Rhesus monkey fed aflatoxin B 1 .


Release of mouse leukemia-sarcoma virus from synchronized cells.


Cyclic adenosine 3',5'-monophosphate in the control of melanoma cell replication and differentiation.


Malignant, non-functional, non-chromaffin paraganglioma of the retroperitoneum.


Hepatoma with unusual associations.

Hepatoma with unusual associations.


Phospholipids of marine origin. VI. The octopus (Octopus vulgaris).


The action of calcium at spinal neurones of the frog. 1. The action of Ca on membrane excitability and synaptic transmission at motoneurones of the isolated spinal cord of the frog has been studied.2. Impulse propagation along presynaptic fibres was unaffected by [Ca] in the range of 0-10 mM in the presence of 1 mM-Mg.3. Motoneurone membrane excitability was within normal ranges when the cord was bathed in low or 0 Ca solutions containing 1 mM-Mg but was depressed in 5 or 10 mM-Ca solutions.4. Spontaneous miniature synaptic potentials were recorded in the presence of tetrodotoxin. The frequencies were reduced but not abolished in the absence of bath Ca, but were increased greater than twofold in 5 or 10 mM-Ca in comparison to those in normal Ringer solution (1 mM-Ca).5. Iontophoretic application of Ca both near to and remotely from the intracellular recording site (presumably in the soma) caused facilitation of elicited post-synaptic potentials.6. It is concluded that the action of Ca at these central synapses is identical to that described at the neuromuscular junction.


Synthesis of the arabinose operon regulator protein in a cell-free system.


Superinfection with Epstein-Barr virus of human lymphoid cell lines of different origin.


Foetal liver tRNA phe  in rat hepatoma.

Foetal liver tRNA phe  in rat hepatoma.


Extraction of soluble gonadotrophin receptors from rat testis.


Androgen "receptor" in rat liver: cytosol "receptor" deficiency in pseudohermaphrodite male rats.


Chlorophyll interactions and light conversion in photosynthesis.


Dopamine: excitatory and inhibitory transmission from a giant dopamine neurone.


Effect of human calcitonin on the sarcoplasmic reticulum of the human heart.


In vivo binding of tritiated actinomycin to cellular chromatin.


Recovery of cerebral energy metabolism after complete ischemia of one hour's duration.


Carcinogenicity of  -hydroxylated dipropylnitrosamine.


Calcium transport and mobilization mediated by 1,25-dihydroxycholecalciferol.


Oxidation of formate and oxalate in peroxisomal preparations from leaves of spinach beet (Beta vulgaris L.).


Cyclic AMP-dependent diphosphoinositide kinase.


Cyclic AMP levels in various tissues of the domestic fowl (Gallus domesticus) as affected by glucagon, epinephrine and insulin.


The effect of adenine nucleotides and dehydroepiandrosterone on the isoenzymes of NADP + -and NAD + -glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from rat adipose tissue.


Adenylate cyclase and the function of cyclic adenosine 3':5'-monophosphate in the leucocidin-treated leucocyte.


Arterial baroreceptor fibers in the recurrent laryngeal nerve.


Mucociliary function during experimentally induced rhinovirus infection in man.


Medical and surgical management of stroke.


A possible explanation for spontaneous breast development in XY gonadal dysgenesis.


The antiquity of age-associated bone demineralization in man.


Adenohypophysis of foetal sheep: correlation of ultrastructure with functional activity.


Structure and physiology of denervated and re-innervated cockroach muscle.


Prevention by angiotensin II antiserum of drinking induced by intracranial angiotensin.


Early and late facilitation of transmission through a sympathetic ganglion and the influence of preganglionic B and C fibres.


Calcium release and vasopressin action in toad bladder.


Surgical treatment of juvenile nasopharyngeal angiofibroma.


Radiographic evaluation of the prevertebral space.


Electrophysiological identification of cell bodies of the tubero-infundibular neurones in the rat. 1. Electrical stimulation of the median eminence induced unit responses in the suprachiasmatic, the ventromedial and the arcuate nuclei of the hypothalamus in the female rat anaesthetized with urethane.2. Arcuate units with constant latency responded in one to one fashion to repetitive stimuli up to 286 Hz.3. A conditioning stimulus just above threshold increased the threshold and latency for responses produced by a test stimulus given within 6 msec after the conditioning stimulus. Absolute refractory period was 1.4-2.0msec.4. A conditioning stimulus just below threshold did not alter the threshold and latency of the responses to test stimuli at any interval.5. A stimulus given within a time period following a spontaneously occurring spike failed to induce a unit response.6. It is concluded that the arcuate nucleus of the hypothalamus includes cell bodies of origin of the tubero-infundibular axons in the rat.


The arterial wall and the process of atherosclerosis.


Effects on self-stimulation behavior of drugs influencing dopaminergic neurotransmission mechanisms.


Idiopathic facial palsy and pregnancy.

Idiopathic facial palsy and pregnancy.


Changes in neuron structure during action potential propagation and synaptic transmission.


The in vitro assay of the herpesvirus of turkeys.


Karyological characterization of primary dog kidney cells in regard to acceptability of the cells as substrate of virus vaccines.


New trends in the preparation of cell substrates for the production of virus vaccines.


Replacement of serum by a soybean protein fraction in a basal tissue culture medium.


Consideration of immunological prophylaxis of tumours.


General discussion the papers of session 3. Developments with viral vaccines.


Problems in the detection of the oncogenic potential of viruses or cell cultures.


Carcinogenesis in germ-free animals.

Carcinogenesis in germ-free animals.


Search for oncogenes in human rhabdomyosarcoma cells.


Natural history studies of the feline RNA tumor virus genoma. I. Detection of group specific antigen and C-type particles.


Cell tumourigenicity detected by heterotransplantation into mice immunosuppressed with anti-lymphocytic serum.


A bacterial protein inducing antiviral resistance and high titers of interferon.


Study of two double-stranded ribonucleic acids of viral origin: interferon inducing and antiviral activities.


Antiviral properties of five strains of Corynebacterium.


The development of different vaccine types against parainfluenza-3 in cattle.


Safety and potency of parainfluenza-3 vaccines for cattle and test procedures.


Developments with bacterial vaccines: cholera.


Possible reasons for the inefficiency of Gram-negative bacterial vaccines.


In vitro infection of sera containing Australia antigen.


The effect of methotrexate and folinic acid therapy on the platelet count.


Brief latency click-evoked potentials during waking and sleep in man.


The inhibition of a p-nitrophenylphosphatase of Streptococcus mutans by fluoride ions.


Pancreatic glucagon in health and disease.


Mammary adenoid cystic carcinoma with unusual features.


Myofiber inclusions.

Myofiber inclusions.


Traumatic optic neuritis.

Traumatic optic neuritis.


Collagenase inhibitors (penicillamine).

Collagenase inhibitors (penicillamine).


Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa.


Subacute demyelinating disease in an adult (diffuse-disseminated sclerosis). Electron microscopic findings.


Epstein-Barr virus in human tumor cells.


The biology of the mouse mammary tumor virus.


Synthesis of mitochondrial deoxyribonucleic acid with a partially purified deoxyribonucleic acid polymerase from the mitochondria of HeLa cells.


Properties and mode of action of a partially purified deoxyribonucleic acid polymerase from the mitochondria of HeLa cells.


Orientation of the cell membrane in ghosts and electron transport particles of Mycobacterium phlei.


A comparison of associated enzyme activities in various deoxyribonucleic acid polymerases.


Responses evoked from the thalamic centrum medianum by painful input: suppression by dorsal funiculus conditioning.


Cyanide-insensitive respiration. I. The steady states of skunk cabbage spadix and bean hypocotyl mitochondria.


Horse liver alcohol dehydrogenase. Amino groups and rate-limiting steps in catalysis.


Mechanism of control of hepatic glycogenesis by insulin.


Nicotinate phosphoribosyltransferase of human erythrocytes. Purification and properties.


Interaction of concanavalin A and wheat germ agglutinin with the insulin receptor of fat cells and liver.


Anthranilate synthetase of Acinetobacter calcoaceticus. Separation and partial characterization of subunits.


The endometrial adenosine cyclic 3':5'-monophosphate-dependent protein kinase. Distribution, subunit structure, and kinetics of adenosine cyclic 3':5'-monophosphate binding.


Structure-function relationships at the active site of nuclease-T'.


Myocardial ultrastructure of young and senescent rats.


Influence of glucagon on the metabolism of xylitol and dihydroxyacetone in the isolated perfused rat liver.


Periodic fibrillar material in membrane-bound bodies in notochordal epithelium of the early chick embryo.


Ultrastructure of sinus venosus innervation in Petromyzon marinus.


From vitamin to hormone.

From vitamin to hormone.


Electron microscopical study on the influence of the preparative conditions on contour length and structure of mitochondrial DNA of mouse liver.


Age related changes of hematologic values in infant Macaca mulatta.


Synergistic role of intestinal flagellates and normal intestinal bacteria in a post-weaning mortality of mice.


Review of recent epizootics in nonhuman primate colonies and their relation to man.


Filariasis in New World monkeys: histochemical differentiation of circulating microfilariae.


Relationship of the vaginal smear to ovarian follicles and the uterus in postpartum Mongolian gerbils.


Infections among Thai gibbons and humans caused by atypical Microsporum canis.


Investigations into the diagnosis and spread of epizootic simian tubrculosis.


The Afghan pika (Ochotona refescens rufescens): a new laboratory animal.


Immune and pathologic consequences of spontaneous Cuterebra myiasis in domestic rabbits (Oryctolagus cuniculus).


Collection of chimpanzee semen with an artificial vagina.


A simple method for skin grafting in germfree mice.


Pneumothorax associated with lung mite lesions in a rhesus monkey.


Growth, longevity, and reproductive life of the Mongolian gerbil.


A simple endotracheal intubation technic for inhalation anesthesia of the rat.


Adamantinoma in a spider monkey (Ateles fusciceps).


Subclinical otitis media associated with Pasteurella multocida infections in New Zealand white rabbits (Oryctolagus cuniculus).


A collapsible restraint apparatus for cardiac bleeding of rabbits.


Tattooing rabbits' ears for identification.


Microsporidiosis (encephalitozoonosis) in the guinea pig.


Thorns of South American clump palm trees in the thoracic organs of owl monkeys (Aotus trivirgatus).


Note on the rabbit ovary.

Note on the rabbit ovary.


Pathogenesis of intrauterine infections in rats due to reovirus type 3. I. Virologic studies.


Protein and messenger RNA requirements for superhelicity of polyoma virus DNA.


DNA virus inhibitory activity of 1- -D-arabinofuranosylcytosine-3',5'-cyclic phosphate.


Differential effect of cytochalasin B on normal and transformed mouse cells.


Management of tumors of the parotid gland.


Nasopharyngeal cancer.

Nasopharyngeal cancer.


Management of cancer of the parotid gland.


Collagenolytic activity in periodontal disease.


Bile acid excretion after disappearance of jaundice in intrahepatic cholestasis of infancy.


Aunt Libby and her cure-alls.

Aunt Libby and her cure-alls.


The interaction between the mitochondrial ATPase (F 1 ) and the ATPase inhibitor.


Water and cytochrome oxidation-reduction reactions.


Cytochrome oxidase from Pseudomonas aeruginosa. I. Purification and some properties.


Cytochrome c-556, a di-heme protein from Pseudomonas aeruginosa.


Electron paramagnetic resonance studies on nitrogenase. II. Interaction of adenosine 5'-triphosphate with azoferredoxin.


Electron paramagnetic resonance studies on nitrogenase. 3. Function of magnesium adenosine 5'-triphosphate and adenosine 5'-diphosphate in catalysis by nitrogenase.


The EPR spectrum of isolated complex 3.

The EPR spectrum of isolated complex 3.


Nuclear magnetic resonance study of the interaction of cytochrome c with cytochrome c peroxidase.


Biochemical basis for the toxic effects of triethyl lead.


Malignancy of bronchial adenoma.

Malignancy of bronchial adenoma.


The role of heparin in the chemotherapy of solid tumors: preliminary clinical trial in carcinoma of the lung.


Influence of hormones on the growth of hepatomas and induction of adenylate and pyruvate kinases.


Effect of alkylating antitumor agents on the binding of DNA to protein.


The mineral content and water compartments of liver and of Morris hepatomata 5123tc and 3924A and the changes of composition occurring during necrosis in hepatoma 3924A.


The net extrusion of calcium and its temporal relation to the accumulation of potassium in slices of rat liver and of Morris hepatomata 5123tc and 3924A.


Lysosomal hyaluronidase activity in normal rat liver and in chemically induced hepatomas.


Orotate phosphoribosyl transferase and orotidylic acid decarboxylase activities in liver and Morris hepatomas.


A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylaminoazobenzene.


Partial characterization of the DNA-dependent DNA polymerases of rat liver and hepatoma.


The influence of dibutyryl cyclic adenosine monophosphate and other substances on human bronchial mucous gland discharge.


Arterial endothelial permeability and vascular disease. The "trap door" effect.


The ageing pattern of human intervertebral disc.


Formation of H adduct radicals in cytosine and its derivatives.


Pseudoachondroplastic dwarfism. A rough-surfaced endoplasmic reticulum storage disorder.


Metaphyseal dysotosis: description of an ultrastructural defect in the epiphyseal plate chondrocytes.


Carcinoma of the rectum: treatment by anterior resection or abdominoperineal excision?


Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins. In an effort to clarify the basis for the reduced cyclic AMP response to catecholamines in leukocytes and lymphocytes from asthmatic donors the response of these cells to prostaglandins has been examined. Cells with an impaired beta adrenergic response had an essentially unaltered response to prostaglandin E(1) (PGE(1)) indicating the presence of selective beta adrenergic blockade. In contrast to what was observed with cells from asthmatic individuals, in normal control leukocytes with reduced catecholamine responsiveness PGE(1) responses were usually reduced as well, suggesting a different mechanism. The excellent cyclic AMP response to PGE(1) in cells from asthmatic donors would suggest that the defect in catecholamine responsiveness is at the level of the beta adrenergic receptor although a contributory role of altered substrate concentrations or increased phosphodiesterase activity is not formally excluded.


Alterations in cyclic AMP metabolism in human bronchial asthma. 3. Leukocyte and lymphocyte responses to steroids. On the basis of serial studies the responsiveness of leukocytes and lymphocytes from asthmatic donors to catecholamines was increased during high dose corticosteroid therapy. Similar changes were observed in the cells of normal control subjects given 200 mg of hydrocortisone intravenously. The increase in responsiveness did not appear to be due to changes in lymphocyte subpopulations although this may be a contributing factor. In an effort to elucidate the basis for the improved response, in vitro effects of glucocorticoids on lymphocyte cyclic AMP concentrations were investigated. Glucocorticoids (prednisolone succinate, hydrocortisone, hydrocortisone phosphate, and hydrocortisone succinate) stimulated cyclic AMP accumulation in asthma and normal control lymphocytes, increases occurring within the first 2 min of incubation. In the absence of theophylline, responses were regularly obtained at 10 muM hydrocortisone and usually at 1 muM hydrocortisone but not at submicromolar steroid concentrations. Theophylline potentiated the cyclic AMP response to glucocorticoids and also increased the percentage of positive responses in the 0.01-1.0 muM corticosteroid range. Combinations of 1 muM hydrocortisone and 1 muM epinephrine were sometimes additive or synergistic but in many instances higher glucocorticoid concentrations were needed to obtain augmentation of the catecholamine response. The in vitro glucocorticoid effects may not fully explain their potentiating action in vivo.


Effects of cycloheximide on the response of intestinal mucosa to cholera enterotoxin. Prior studies have indicated that effects of cholera enterotoxin (CT) on the small intestine are delayed in onset and involve an interaction with adenyl cyclase in the mucosa. It has also been shown that the administration of cycloheximide to rabbits in doses which inhibit crypt cell mitoses (20 mg/kg), diminishes CT-induced fluid production in jejunal loops. These latter studies have been interpreted as indications that CT-related intestinal secretion is a crypt cell function and that it is mediated by a CT-induced protein. The present study was undertaken to delineate more precisely the nature of the interaction in the intestine between cycloheximide and cholera toxin. Pretreatment of rabbits with cycloheximide reduced by 60% the secretory response to CT in isolated ileal loops with intact blood supply. Sodium and chloride flux measurements on mucosa isolated from these and control loops indicated that this antisecretory effect of cycloheximide persists in vitro. Measurements of radioactive leucine incorporation into mucosal protein indicated that the dose of cycloheximide employed inhibited protein synthesis by 90%. This inhibitory effect was shown to be independent of any effect of cycloheximide on amino acid uptake across the brush border. Measurements of adenyl cyclase activity and cyclic AMP levels in ileal mucosa of cycloheximide pretreated and control animals indicated that cycloheximide did not diminish the CT-induced increases in these parameters. These observations demonstrate that cycloheximide reduces CT-induced intestinal fluid production without interfering with the CT-induced augmentation of adenyl cyclase activity or the consequent rise in cyclic. AMP concentration. Since the antisecretory effect of cycloheximide persists in vitro, it probably involves a direct interaction of the antibiotic with mucosal cell ion transport mechanisms rather than an indirect effect mediated by other humoral or neurogenic factors. The present observations also suggest that the secretory response of the intestine to CT involves neither the synthesis of new adenyl cyclase nor that of a protein modifying its activity.


The interconversion of oestrone and oestradiol-17  and the concentration of oestradiol-17  receptors in cultured rabbit uterus.


Effect of conjugated dihydroxy bile salts on electrolyte transport in rat colon. The mechanism by which excess quantities of bile salts in the colon produce diarrhea is not known. Therefore, experiments were performed in which the effect of conjugated dihydroxy bile salts on ion transport was evaluated in the in vitro short-circuited rat colon. 2 mM glycochenodeoxycholic acid (GCDC), taurochenodeoxycholic acid (TCDC), or taurodeoxycholic acid caused a prompt increase in short-circuit current (I(sc)) and electrical potential difference (PD). Similar results were obtained when theophylline was added. Removal of HCO(2) and C1 prevented the effects of both bile salts and theophylline. Pretreatment with theophylline blocked the increase in I(sc) and PD produced by TCDC and pretreatment with either TCDC or GCDC inhibited the expected theophylline response. Na fluxes in the presence of both TCDC and theophylline demonstrated a decrease in net absorption; and TCDC decreased net C1 absorption and theophylline caused a reversal of net C1 absorption to net C1 secretion. It is proposed that the diarrhea associated with cholerheic enteropathy is produced by active anion secretion possibly mediated by cyclic AMP.


Effect of oestrogen upon parturition, maternal behaviour and lactation in ovariectomized pregnant rats.


The relationship of the splanchnic, hepatic and renal clearance rates to the metabolic clearance rate of cortisol in conscious sheep.


The role of transcortin in the regulation of corticotrophin secretion.


Morphological differentiation of adrenal cortical cells induced by a 40-minute exposure to corticotrophin.


Effect of adrenocorticotrophin on 21- and 11 -hydroxylase activity in the biosynthesis of cortisol.


The innervation of the juxtaglomerular apparatus and surrounding tubules: a quantitative analysis by serial section electron microscopy.


Ultrastructural features of cellular maturation and aging in human trophoblast.


Association between endoplasmic reticulum and vacuoles in frozen-etched root tips.


Effect of organic phosphates on the magnetic susceptibility of human deoxyhaemoglobin.


Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver.


The role of the community nurse concerned with after-care.


Corticoids and respiratory distress.

Corticoids and respiratory distress.


Serum total corticoid and cortisol levels in premature infants with respiratory distress syndrome.


Silica urolithiasis in dogs fed an atherogenic diet.


Antiviral immune hemolysis.

Antiviral immune hemolysis.


Interferon induction by rhinoviruses and effect of interferon on rhinovirus yields in human cell lines.


Uranyl nitrate induced acute renal failure in the rat: effect of varying doses and saline loading.


The cytotoxic effect of human immune sera on Herpesvirus hominis infected cells.


Collagenase activity in tissues of selenium responsive myopathic lambs.


Effect of adrenal arterial infusion of different Mg 2+  concentrations on the spontaneous release of catecholamines in the anesthetized dog.


Ovarian weight changes in immature female rats as a function of dose and exposure time to PMS.


Angiotensins lung converting enzyme.

Angiotensins lung converting enzyme.


An artifact resembling silver grains found in microautoradiography of lettuce fruits.


Differentiation of nephrotensin from angiotensin I and II.


Partial mastectomy for carcinoma of the breast.


Subcutaneous glomus tumors.

Subcutaneous glomus tumors.


A comparison of the treatment of gas gangrene with and without hyperbaric oxygen.


Scanning electron microscopy of erythrocytes adsorbed by ribonucleic acid virus-infected cells in vitro.


Comparative study of experimental Clostridium perfringens infection in dogs treated with antibiotics, surgery, and hyperbaric oxygen.


Naturally occurring infection of calves with a bovine adenovirus.


C-type virus particles in avian bursa of Fabricius cells grown in vitro.


Distribution of thyroid, parathyroid, and ultimobranchial hypocalcemic factors in birds. II. Morphology, histochemistry, and hypocalcemic activity of pigeon thyroid glands.


Kinetic and electrophoretic abnormality of cyclic AMP phosphodiesterase in genetically obese mouse adipocytes.


Effects of progesterone on the binding of estradiol-receptor to rabbit uterine chromatin.


Reactive lysine residues in horse liver alcohol dehydrogenase.


Topography of nucleic acid helices in solutions. 28. Evidence for a dynamic structure of DNA in solution.


Inhibitor of adenosine 3',5'-monophosphate binding and protein kinase activity in leucocyte lysosomes.


Lack of influence of mitochondrial genetical information on the multiplication of Herpes simplex virus in HeLa cells.


Resonance Raman scattering on the haem group of cytochrome c.


The presence of  -mannosidic linkage in acidic glycopeptide from porcine thyroglobulin.


Two-dimensional polyacrylamide gel electrophoresis of acid extractable nuclear proteins of normal rat liver and Novikoff hepatoma ascites cells.


Some current concepts of the pneumoconioses.


Differences in the metabolism of phospholipids depending on cell population density.


Effect of ribosomal protein L12 upon initiation factor IF-2 activities.


Assembly and secretion of very low density lipoproteins by rat liver following inhibition of protein synthesis with cycloheximide.


Colchicine-induced inhibition of very low density lipoprotein release by rat liver in vivo.


Methanesulfonates: the relationship of structure to antitumor activity.


Foot-and-mouth disease circulating antibodies in convalescent cattle.


Ventilatory effects of aerosolized kanamycin and polymyxin.


Effect of compounds on a spectrum of rat tumors.


Granular cell myoblastoma of trachea associated with pregnancy.


Rapid method for screening for galactosemia and galactokinase deficiency by measuring galactose in whole blood spotted on paper.


Pathogenesis of foot-and-mouth disease in experimentally infected pigs.


Effects of a partially purified factor from chick embryos on macromolecular synthesis of embryonic pancreatic epithelia.


Stability of erythrocytic enzymes for screening tests.


A genically determined abnormality in the number and arrangement of basal bodies in a ciliate.


Decreased formation of syncytial plaques in the XC-test with a double-cloned hypotetraploid XC-cell line and evidence of budding C-type particles in this and ordinary hypodiploid XC-cell lines.


A method of recording nerve terminal activity in the frog.


Diffusion of pyrimethamine from silicone rubber and flexible epoxy drug capsules.


Alteration of immunocompetence by mammary tumor virus.


Brief communication: specific transplantation antigens of murine neoplasms induced by visna and progressive pneumonia viruses.


Question: do herpesviruses cause cancer? Answer: of course they do.


L-asparaginase-induced alterations of Burkitt's lymphoma cells.


Inhibition of growth and transformation of human cells by interferon.


Isolation of plasma membrane antigens from Epstein-Barr virus-infected lymphoid cells.


Ultrastructural and complement-fixation studies on suspension cultures derived from human solid tumors.


Induction of tumors in the liver of hamsters by an avian adenovirus (CELO).


Mouse strain-related differences in the biologic and immunologic responses to a murine sarcoma virus.


Lipid composition of Quaking mouse myelin: comparison with normal mouse myelin in the adult and during development.


Serum glucose-6-phosphatase levels in normal pregnancy.


GABA transport by nerve ending fractions of cat brain.


A case of genital herpesvirus infection in pregnancy.


Schistosome motility measurements: response to drugs.


Cyclic adenosine monophosphate antagonism of morphine analgesia.


Effects of cyclic 3',5'-adenosine monophosphate on morphine tolerance and physical dependence.


Study of phosphodiesterase inhibitors on lipolysis, phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in isolated fat cells.


Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.


A possible etiology of contractility impairment of vascular smooth muscle from spontaneously hypertensive rats.


Intravenously given conjugated estrogens. Lack of effect of capillary stability.


Vitamin D: a reawakening.

Vitamin D: a reawakening.


The effect of variations in LET and cell cycle on radiation hepatocarcinogenesis.


A qualitative and quantitative analysis of cuneate and gracile nuclei and of the dorsal column fibres.


The sleep polygram: a potentially useful tool for clinical assessment in human infants.


On the significance of curvilinear bodies in late infantile lipidosis.


Fetal renal hamartoma--a benign tumor to be distinguished from Wilms' tumor. Report of 3 cases.


Endometriosis of the bowel: role of bowel resection, superficial excision and oophorectomy in treatment.


Significance of postoperative estrogen therapy on the occurrence and clinical course of cancer.


Diphosphoglycerate mutase and 2,3-diphosphoglycerate phosphatase activities of red cells: comparative electrophoretic study.


On the regulation of cyclic 3',5' adenosine monophosphate levels in bacteria. Stimulation of adenyl cyclase activity in vitro by glucose in a mutant of E. coli B-r.


Electron paramagnetic resonance of single crystal deoxycobaltohemoglobin.


pH profiles of proline transport with membrane vesicles from Mycobacterium phlei with artificial and natural electron donors.


The detection of a bound ferredoxin in the photosynthetic lamellae of blue-green algae and other oxygen evolving photosynthetic organisms.


Chain non-equivalence in nitric oxide binding to hemoglobin.


Differences in the physical properties of collagenases isolated from rheumatoid synovium and human skin.


Ion and pH gradients across the transport membrane of mitochondria following Mn ++  uptake in the presence of acetate.


Site of impairment of oxidative phosphorylation in irradiated rats.


Studies on the accessibility barrier of NADH to cytochromes b in pigeon-heart mitochondria.


Studies on electron transport associated with photosystem I. I. Functional site of plastocyanin: inhibitory effects of HgCl 2  on electron transport and plastocyanin in chloroplasts.


Reduction of the tetrazolium salts in cells and tissue sections incubated without substrate.


The use of ketamine hydrochloride anaesthesia for radiotherapy in young children.


Effects of methallibure on early pregnancy in swine.


Fat mobilizing lipase in relation to fatness in lambs.


Corticosteroidogenesis in isolated adrenal cells: effect of adrenocorticotrophic hormone, adenosine 3',5'-monophosphate and   1-24  adrenocorticotrophic hormone diazotized to polyacrylamide.


Interference of some pesticides in the milk phosphatase pasteurization test.


The zona glomerulosa and corticotrophin: a genetic study in mice.


Regulation of the permeability to water in toad urinary bladder: the effect of copper.


A comparison of the effects of pituitary hormones and aminophylline on progestational hormone production by the rabbit ovary in vivo.


Promotion of pituitary prolactin release in rats by dibutyryl adenosine 3',5'-monophosphate.


The conversion of angiotensin I to angiotensin II by rabbit glomeruli.


Adrenal and testicular contribution to plasma oestrogens.


Quantitative study on RNA metabolism in mononucleate and Sendai virus-induced multinucleate cells.


Sleep and activity in a psychotic depression.


Prevalence of deformities and disabilities among leprosy patients in an endemic area. II. Nerve involvement in the limbs.


Multiple pulmonary metastases from adenoid cystic carcinoma of ceruminous glands of external auditory canal. A case report and review of the literature.


Cholestyramine: factors limiting its antidiarrheal effect in patients resected for regional enteritis.


Surgical treatment of amebic  liver abscess. Surgical treatment of hepatic  amebiasis.


Calcifying mucinous adenocarcinoma of the gallbladder.


Aortic mitochondrial function in experimentally induced atherosclerosis in swine and rabbits.


Interaction of a spin-labeled analog of acetyl coenzyme A with citrate synthase. Paramagnetic resonance and proton relaxation rate studies of binary and ternary complexes.


Effect of insulin and growth hormone on rat liver cyclic nucleotide phosphodiesterase.


Chemistry of the adenosine monophosphate site of rabbit muscle glycogen phosphorylase. II. Properties of 8-(m-(m-gluorosulfonylbenzamido) benzylthio)adenine-modified phosphorylase.


Dilatometry biological membranes.

Dilatometry biological membranes.


Structure of the lipid phase in cell envelope vesicles from Halobacterium cutirubrum.


Composition and structure of the O-specific side chain of endotoxin from Serratia marcescens 08.


Nuclear double-stranded ribonucleic acid of mammalian cells. Characteristics and biosynthesis.


A marker for medullary carcinoma of thyroid.


Prospective study of cytomegalovirus infection in pregnancy. In a prospective study of cytomegalovirus infection in 1,040 pregnant women in London 319 (42%) of the white Englishwomen but only 28 (10%) of the immigrant Asian women were without antibodies at the onset of pregnancy. Out of 254 susceptible white women and 16 susceptible Asian women 8 (3%) and 3 (16%) respectively experienced primary infection during the course of pregnancy. The overall incidence of fetal infection after primary infection in the mother was almost 50%, and was higher in early pregnancy. One out of the five infected infants was found to be mentally retarded.Reactivation of latent infection was recognized in 0.7-2.9% of pregnant women; this occurred without involving the fetus.


Serum alkaline phosphatase and rickets.

Serum alkaline phosphatase and rickets.


Sarcoma after injection of intramuscular iron. Two cases are presented of sarcomata arising at the site of previous iron dextran injections. One of the tumours showed a histological pattern associated with iron dextran administration in animal experiments.


Immunological destruction in vitro of cytomegalovirus infected cells.


Care of the patient with inoperable lung cancer.


Critical issues in psychiatry: a call for a reassessment of our nation's mental health care.


Consumer participation in mental health programs.


Action of miracil D and related compounds on DNA and RNA synthesis in regenerating liver and hepatomas.


Counteractions of the blocking of cell-mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats.


Dream recall: facts and perspectives.

Dream recall: facts and perspectives.


Antibodies to EB virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients.


Purification of antibodies to membrane antigens of hamster cells transformed by SV40 and binding of the radioiodinated, purified antibodies to intact cells.


SV40-induced transformation of cells of the lizard Gekko gecko.


Genetic stability of the sarcoma viruses in murine and avian sarcoma virus-transformed nonproducer cells.


Effects of SV40 virus on the chromosomes of poikilothermic cells (Gekko gecko) cultivated at different temperatures.


Radioimmunoassay of carcinoembryonic antigen in extracts of human colon and stomach.


The inducible alkaline phosphatase of rat heart: partial purification of the enzyme and its substrate specificity.


Plasma cortisol during normal glucose tolerance.


Hepatoma originated in the retroperitoneal space. Report of a case.


Fructose-1,6-diphosphatase in DMBA-induced rat mammary tumours.


Mixed tumors of the lower lip.

Mixed tumors of the lower lip.


Study of the interaction of  -glycerophosphate dehydrogenase and NAD-H by the methods of circular dichroism and fluorimetry.


Primary gastric neoplasia in the dog: a clinico-pathological study.


Biochemical effects of 1,1-dichloroethylene in rats: dissociation of its hepatotoxicity from a lipoperoxidative mechanism.


Nature of the changes in the protein fluorescence of the mitochondria during a change in their functional state.


Biosynthesis of collagen in a chick embryo cell-free microsomal system.


Study of the ability of a DNA polymerase mutant E. coli K12 pol A1 for elimination of single-stranded breaks in DNA caused by methyl methanesulfonate.


Biological effects of Corynebacterium parvum. IV. Adjuvant and inhibitory activities on B lymphocytes.


The regeneration of skeletal muscle. A review.


Investigation of the mechanism of spectral changes in carotenoids in the chromatophores of Rhodospirillum rubrum.


Gradient gel electrophoresis of human plasma lipoproteins.


A common error in measurements of 340 nm.


Oestrogen and oestrogen conjugate concentrations in late pregnancy plasma.


The specificity of the estrogen receptor of human uterus.


Testosterone "receptors" in purified nuclei of rat anterior hypophysis.


Correlations between mood, weight, and electrolytes during the menstrual cycle: a renin-angiotensin-aldosterone hypothesis of premenstrual tension.


Vasospasm in ischemic heart disease--a hypothesis.


Contrasting effects of plastocyanin on the photoreduction and photooxidation of cytochrome f in chloroplasts.


In vitro studies on yeast cytochrome c peroxidase and its possible function in the electron transfer and energy coupling reactions.


Nitrogenase. 3. Nitrogenaseless mutants of Azotobacter vinelandii: activities, cross-reactions and EPR spectra.


Electron transfer in cytochrome c: role of the polypeptide chain.


Nature of the activation of succinate dehydrogenase by various effectors and in hypobaria and hypoxia.


Oxidative phosphorylation in mitochondria isolated from human fibroblasts.


Freeze-fracture studies on mitochondria from wild-type and respiratory-deficient yeasts.


Effect of adrenocorticotropin (ACTH) upon the drug response of intact and adrenalectomized rats.


Sodium retention versus renin-angiotensin system in experimental renal hypertension.


Electron microscopy in the diagnosis of pleural mesotheliomas.


Histology and ultrastructure of an oncocytic adenoma of the human pituitary.


Pathogenesis of Hodgkin's disease: separation and culture of different kinds of cells from Hodgkin's disease in a sterile isokinetic gradient of Ficoll in tissue culture medium.


Addison's disease secondary to metastatic carcinoma: an example of adrenocortical and adrenomedullary insuffiency.


Posterior hypothalamus and the regulation of body temperature.


Embryonic antigen expression in chemically induced rat hepatomas and sarcomas.


Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation.


The transformation of BHK 21 hamster cells by simian virus 40.


Pigmented skin tumors.

Pigmented skin tumors.


Variations in sarcoma and leukemia virus activity in somatic cell hybrids.


The SV40 S antigen; a carcinoembryonic-type antigen of the hamster?


Human cancer in households containing cats with malignant lymphoma.


Australia antigen in Singapore Chinese patients with hepatocellular carcinoma and comparison groups: influence of technique sensitivity on differential frequencies.


Feline malignant lymphoma: environmental factors and the occurrence of this viral cancer in cats.


Dietary aspects of hyperlipidemia.

Dietary aspects of hyperlipidemia.


Effect of certain biologic and antibacterial agents on development of acute respiratory tract disease in weaned beef calves.


Relationships between antimicrobial activities and chemically reactive functions in viomycin.


Chemical studies on tuberactinomycin. 3. The chemical structure of viomycin (tuberactinomycin B).


Cyclic AMP phosphodiesterase activity in the midgut of Manduca sexta.


Parasitization of the parasite.

Parasitization of the parasite.


Single unit responses in the neospinothalamic system of the cat.


Effects of dietary manipulation on adipose tissue glycerokinase activity and plasma metabolite levels in the chicken (Gallus domesticus).


Effects of blunted sympathetic nervous system response on regional tissue perfusion in experimental endotoxic shock.


Central control of movement. VI. Strategies and tactics in research on central control of movement.


Central control of movement. IV. Control systems operating on spinal reflex mechanisms.


Cranio-orbital resection and neck dissection for a recurrent mixed tumor of the lacrimal gland. Case report.


Actomyosin-like protein in brain.

Actomyosin-like protein in brain.


Epstein-Barr virus: detection of genome in somatic cell hybrids of Burkitt lymphoblastoid cells. Somatic cell hybrids of Burkitt lymphoblastoid cells, from which Epstein-Barr virus can be recovered, were examined for the presence of virus DNA by DNA-RNA hybridization. Four clones of hybrid cells, each negative for virus antigens by immunofluorescence, contained virus DNA in varying genomic equivalents. The number of virus genome equivalents increased in the hybrid cells after induction of virus with iododeoxyuridine.


The metabolism in vivo 4,16-androstadien-3-one in man. Occurrence of 16-dehydro C 19  steroids, androstane-3,16,17-triols and other metabolites in urine.


Isolation and identification of 16alpha, 18-dihydroxydeoxycorticosterone from human adrenal gland incubations.


The occurrence and subcellular localization of 3 -hydroxysteroid dehydrogenase in adult rat brain.


Adenovirus type 12 surface antigen detected by immunofluorescence in infected KB cells.


Transcriptive functions of Sendai firus nucleocapsid in infected cells.


Interaction of genes controlling resistance to RSV(RAV-O).


Properties of an SV40 transformed African green monkey kidney (BSC-1) cell line: interactions between SV40 and cellular DNA metabolism.


The identification of the circular forms of SV40 DNA in whole infected cell preparations.


Effects of 2-deoxy-D-glucose on herpes simplex virus replication.


Effect of actinomycin D on potato virus X multiplication in Datura stramonium leaves.


Isolation of the structural polypeptides of foot-and-mouth disease virus and analysis of their C-terminal sequences.


A temperature-sensitive mutant of simian virus 40 affecting transforming ability.


Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses.


Incorporation of 5-iodo-2'-deoxyuridine (IUdR) into SV40 DNA.


Control of group-specific antigen synthesis by the defective Gazdar murine sarcoma virus genome.


Base specific methylase activity in RNA tumor viruses: avian leukosis virion-associated RNA methylase(s).


Iodination of vesicular stomatitis virus with lactoperoxidase.


Cooperative onset of a different state of water in the presence of macromolecules.


An oxygen magnetic resonance study of water in frog skeletal muscle.


Laboratory calibration of a technique for determination of respirable quartz in mine air.


Supramolecular biology: a solid state physical approach to ion and electron transport.


Implications of diffusion coefficient measurements for the structure of cellular water.


The diffusion of water in striated muscle.


The oxidation of N,N'-bis(4-aminophenyl)-N,N'-dimethylethylenediamine (BED) by rat liver.


The effect of GTP hydrolysis by the peptide elongation enzymes on the sedimentation of ribosomes bearing peptidyl-tRNA and on the susceptibility of ribosome-bound tRNA to hydrolysis by  ribonuclease.


Effect of substrate on the spin state of cytochrome P-450 in hepatic microsomes.


The inactivation of lactoperoxidase and the acyl phosphatase activity of oxidized glyceraldehyde-3-phosphate dehydrogenase by phenlyhydrazine and phenyldiimide.


31 P and  13 C nmr measurements of a fructose-1-phosphate, Mn (II) and fructose 1,6-diphosphatase complex.


Hippocampal EEG and behavior: changes in amplitude and frequency of RSA (theta rhythm) associated with spontaneous and learned movement patterns in rats and cats.


Incremental and decremental processes in Limulus ganglia: stimulus frequency and ganglion organization influences.


Circular dichroism of cytochrome oxidase, cytochrome b 566 , and cytochrome c in beef heart mitochondrial membrane fragments.


Cytochrome oxidase from Pseudomonas aeruginosa. I. Reaction with copper protein.


Iron protein content of Thiocapsapfennigii, a purple sulfur bacterium of atypical chlorophyll composition.


Primary events in the photosynthetic reaction centre from Rhodopseudomonas spheroides strain R26: triplet and oxidized states of bacteriochlorophyll and the identification of the primary electron acceptor.


A peroxide-dependent reduction of cytochrome c by NADH.


Hydrogen peroxide generating system in hog thyroid microsomes.


Studies on the metabolites of phylloquinone (vitamin K 1 ) in the urine of man.


Adenylate cyclase activity in normal and leukemic human leukocytes as determined by a radioimmunoassay for cyclic AMP.


Regulation of renal glycogen synthase. Interconversion of two forms in vitro.


Regulation of glycogen phosphorylase a phosphatase in Neurospora crassa.


Occurrence of a galactofuranose disaccharide in immunoadjuvant fractions of Mycobacterium tuberculosis (Cell walls and wax D).


Adenosine 3':5'-monophosphate-dependent and independent histone kinases isolated from human tonsillar lymphocytes.


Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: concentrations in Morris hepatomas of different growth rates.


Inhibition of metabolic effects of growth hormone by various inhibitors of cyclic nucleotide phosphodiesterase.


Firing patterns of Purkinje cells in the cat cerebellum for different maintained positions of the limbs.


Temporal sequence of cerebellar Purkinje and nuclear activity in relation to the acoustic startle  response.


Attempted suicide: a description of the pre and post suicidal states.


Liberal telephone policy in treatment and aftercare helps reduce readmissions.


Baroreceptor activity in normotensive and hypertensive uremic patients.


Central response to infra-red stimulation of the pit receptors in a crotaline  snake, Trimeresurus flavoviridis.


Integration of sensory and centrally programmed components in generation of cyclical feeding activity of Helisoma trivolvis.


Color and spatial specificity of single units in Rhesus monkey foveal striate cortex.


Histamine and cyclic 3',5'-AMP in gastric acid secretion.


Influence of cell-free ascites fluid and adenosine 3'5'-cyclic monophosphate upon the cell kinetics of Ehrlich's ascites carcinoma.


Oestrogen receptor binding is not restricted to target nuclei.


Thrombosthenin, the contractile protein of blood platelets. New facts and problems.


Epstein-Barr virus in human disease.

Epstein-Barr virus in human disease.


ESR study of a new anthraquinone glycoside.


Psychiatry, through mental health to human services--what next?


The planned obsolescence of psychiatric research.


Cellular biochemistry of narcotic analgesic drugs in the central nervous system of the rat.


Effect of cortisol on neuraminic acid concentration of normal and polyoma-transformed mouse cells in culture.


Bovine herpes mammillitis virus and vulvo-vaginitis.


In vivo effect of adenosine 3',5'-monophosphate on Ehrlich ascites tumour cells.


Endocrine control of fetal lung development in the rabbit.


Neurologic complications following lymphangiography. Possible mechanisms and a case of blindness.


Pupillary inhibition of delay during Pavlovian conditioning of paralyzed cats.


Reticular units: relations between responses to sensory stimulation and responses to neurohumors.


4'-Thioadenosine 3'5'-cyclic phosphate and derivatives. Chemical synthesis and hydrolysis by phosphodiesterase.


Biosynthesis of glutamate dehydrogenase in rat liver. Demonstration of its microsomal localization and hypothetical mechanism of transfer to mitochondria.


The lactate dehydrogenase catalyzed reduction of pyruvate. Active substrate and substrate inhibition.


The mechanism of polymyxin B action and selectivity toward biologic membranes.


Isolation and partial chemical characterization of cell-surface glycopeptides from AS-30D rat hepatoma which possess binding sites for wheat germ agglutinin and concanavalin A.


Estrogen receptors in the rat uterus. Relationship between cytoplasmic and nuclear forms of the estrogen binding protein.


Reaction of diethyl pyrocarbonate with nucleic acid components. Adenosine-containing nucleotides and dinucleoside phosphates.


Role of silicon in diatom metabolism. II. Endogenous nucleoside triphosphate pools during silicic acid starvation of synchronized Cylindrotheca fusiformis.


Role of silicon in diatom metabolism. 3. The effects of silicic acid on DNA polymerase, TMP kinase and DNA synthesis in Cylindrotheca fusiformis.


Fractionation of denatured bacterial DNA on methylate albumin kieselguhr columns. Is it strand separation?


The discharge from primary endings of muscle spindles during reflex activation of fusimotor neurones in the lightly anaesthetised and spinal cat.


Spinal and medullary reflex components of the somatosympathetic reflex discharges evoked by stimulation of the group IV somatic afferents.


The adenosine 3',5'-monophosphate content of brain tissue obtained by an ultra-rapid freezing technique.


Development of binocular single units in the optic tectum of frogs raised with disparate stimulation to the eyes.


Synaptic delay: its effect on information transmission in the crayfish caudal photoreceptor system.


Sleep patterns related to rearing rats in enriched and impoverished environments.


Excitatory and inhibitory inputs to single neurones in the solitary tract nucleus and adjacent reticular formation.


Effects of chlorpromazine on sleep in cats pretreated with para-chlorophenylalanine.


Responses of red nucleus neurones to cutaneous afferent inputs.


Unit responses recorded from cervical spinal cord of awake monkey.


Habituation of the flexor reflex: inhibitory build-up or synaptic depression?


The joint peristimulus-time scatter diagram is an index of the operational significance of a synapse.


Convulsant actions of penicillin: effects on inhibitory mechanisms.


Action of penicillin on inhibitory processes in the cat's cortex.


Metastatic mammary carcinoma in the eyelid with histiocytoid appearance.


Lateral inhibition in ambylopia: VER and metacontrast.


Centrifugal effects on the cat electroretinogram after section of one optic nerve.


Personal styles of program implementors: a case study in community mental health failure.


Will success spoil mental health care?

Will success spoil mental health care?


Pathology of the adventitial dermis. Anatomic observations and biologic speculations.


The synovitis of acute gouty arthritis. A light and electron microscopic study.


Florid subareolar duct papillomatosis (nipple adenoma) and mammary carcinoma: report of three cases.


Interference and two-tone inhibition.

Interference and two-tone inhibition.


Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. Colicinogenic factors ColE1 and ColE2 are bacterial plasmids that exist in Escherichia coli as supercoiled deoxyribonucleic acid (DNA) and as strand-specific, relaxation complexes of supercoiled DNA and protein. Newly replicated ColE1 DNA becomes complexed with protein after the replication event. This association of DNA and protein can take place under conditions in which DNA or protein synthesis is arrested. The addition of cyclic adenosine monophosphate (c-AMP) to normal cells growing in glucose medium results in a six- to tenfold stimulation in the rate of synthesis of the protein component(s) of the complex and a three- to fivefold stimulation in the rate of ColE1 DNA replication. Employing mutants deficient in catabolite gene activator protein or adenylate cyclase, it was shown that synthesis of both the plasmid-determined protein colicin E1 and the protein component(s) of the ColE1 relaxation complex is mediated through the c-AMP-catabolite gene activator protein system. Addition of c-AMP to ColE2-containing cells results in the stimulation of synthesis of ColE2 DNA and relaxation protein(s) as well as in the production of a protein component of the ColE2 relaxation complex that renders it sensitive to induced relaxation by heat treatment. In the case of ColE2, synthesis of the relaxation protein(s) is not dependent upon catabolite gene activator protein.


A paracrystalline inclusion formed during sporulation of enterotoxin-producing strains of Clostridium perfringens type A. A large paracrystalline inclusion is formed by certain strains of Clostridium perfringens type A during spore morphogenesis. In most cell thin sections, the inclusion appeared rod-shaped when sectioned at an angle perpendicular to its longer axis, and circular or oval-shaped when sectioned at an angle parallel to its longer axis. Measurements performed on electron micrographs of inclusions sectioned to reveal the rod shape indicated a fairly consistent thickness (width) of 192 +/- 23 nm. The length of the inclusions varied considerably with a maximum of approximately 2,120 nm being observed. Ultrastructurally, the inclusion was composed of closely packed, periodically spaced, parallel layers. Usually a single inclusion was randomly located in the cytoplasm of the cell. Two inclusions per cell were rarely observed. The inclusion was formed only by ent(+) strains of C. perfringens. Mutants of the ent(+) strain NCTC 8798 that were altered in their sporulating and enterotoxin-producing capacities and revertants of these mutants were tested for inclusion formation. The results indicate that, as with the ent(+) trait, a direct relationship exists between inclusion formation and spore formation. The synthesis of enterotoxin, formation of a morphologically distinct inclusion, and the initial deposition of discontinuous coat fragments around the forespore appear to be events closely related in time during spore morphogenesis.


Cyclic adenosine monophosphate-independent mutants of the lactose operon of Escherichia coli. In Escherichia coli the transcription of the lactose operon, like other catabolite-sensitive operons, requires catabolite gene activator protein and 3',5'-cyclic adenosine monophosphate in addition to ribonucleic acid polymerase. We isolated and analyzed lac(+) revertants from a crp(-) strain of E. coli. We found that revertants with a higher level of expression only for the lac operon lie in the lac promoter region. These promoter mutations have no effect on operator or repressor function. Two of the revertants in which the lesions have been more precisely mapped carry mutations in the operator proximal segment of the promoter.


Characterization of a cold-sensitive hisW mutant of Salmonella typhimurium. A cold-sensitive mutant of Salmonella typhimurium LT2 that grows at 37 C but not at 20 C has altered repression regulation in at least two amino acid biosynthetic pathways (histidine and isoleucine). The lesion conferring cold sensitivity that is linked with hisW is recessive. Assays for the acceptance of some amino acids by transfer ribonucleic acid (tRNA) reveal a decreased ability of the mutant tRNA to accept arginine, phenylalanine, and histidine. A mutation in a gene for tRNA maturation is a likely possibility for the mutation producing these effects on growth, regulation, and amino acid acceptance.


ACTH and cortisol secretory patterns in man.


Chorionic gonadotropin sensitive adenylate cyclase in human term placenta.


Studies on calciferol metabolism. VII. The renal production of the biologically active form of vitamin D, 1,25-dihydroxycholecalciferol; species, tissue and subcellular distribution.


Differential effect of cyclic adenosine monophosphate on the secretion of human placental lactogen and human chorionic gonadotropin.


Endemic goiter prevention by iodized oil: a reassessment.


The ascending fiber projections from the principal sensory trigeminal nucleus in the rat.


Reciprocal point-to-point connections between parastriate and striate cortex in the squirrel monkey (Saimiri).


Injection of ACTH induces recovery from shuttle-box avoidance deficits in rats with amygdaloid lesions.


Changes in polarization of central branches of myelinated mechanoreceptor and nociceptor fibers during noxious and innocuous stimulation of the skin.


Correlations of neuronal spike discharges produced by monosynaptic connections and by common inputs.


Convergence of cutaneous and preoptic region thermal afferents on posterior hypothalamic neurons.


Distributed neuronal oscillators and efference copy in the feeding system of Pleurobranchaea.


Physiology of vision in the mollusk Lima scabra.


Peripheral somatic activation of neurons in the cat red nucleus.


Virus-induced transformation without cell division. Interference with the cell cycle by vinblastine sulfate immediately after cells were infected with Rous sarcoma virus had little effect on the a development of two metabolic changes that occur in transformed cells. These results, along with an earlier demonstration of morphological changes developing in infected nondividing cells, demonstrate that the phenotypic development of the malignant state can occur without the intervention of cell divisions after infection by Rous sarcoma virus.


On the use of psychiatric diagnosis for comparing psychiatric populations.


Evaluation of community psychiatric practice.


Electrical transmission between symmetrical neurons in leech ganglia.


Cerebellar unit responses to repetitive stimulation of somatic nerves.


An evaluation of immunological indicators for amebic disease prevalence.


Mucinous (adenocystic) carcinoma of the eyelid.


Studies of SV 40 DNA. V. Conversion of circular to linear SV 40 DNA by restriction endonuclease from Escherichia coli B.


The identification of different structural classes of nucleic acids by electrophoresis in polyacrylamide gels of different concentration.


In vivo and in vitro effects of thyrotropin on ribosomal pattern of dog thyroid.


The primary electron acceptor of photosystem. I.


Biosynthesis of mitochondrial enzymes.

Biosynthesis of mitochondrial enzymes.


Conversion of angiotensin I into angiotensin II in the isolated perfused rat kidney.


Lipoproteins in relation to skin disease.


Structure of normal and pathological lipoproteins.


Carbohydrate metabolism of larval Schistosoma mansoni.


The intranuclear bodies of Entamoeba.

The intranuclear bodies of Entamoeba.


Beta lipoprotein protein turnover: an approach to the understanding of drug and disease mechanisms.


The surface active lysosome of Entamoeba histolytica.


The estimation of human renin-substrate concentration by radioimmunoassay of angiotensin I.


Steroid hormones and their receptors.

Steroid hormones and their receptors.


Action of prostaglandin E 2  and of luteinizing hormone on ovarian adenylate cyclase, protein kinase and ornithine decarboxylase activity during postnatal development and maturity in the rat.


The regulation of intestinal calcium transport by vitamin D.


Subcutaneous growth of human tumours in mice.


Macrophage nonimmunologic recognition: target cell factors related to contact inhibition. Activated mouse macrophages were not cytotoxic to contact-inhibited nontumorigenic 3T3 fibroblasts, but caused marked destruction to non-contact-inhibited, tumorigenic 3T12 and simian virus 40-transformed fibroblasts. Nonimmunologic recognition and destruction of target cells by activated macrophages is independent of altered morphology, abnormal karyotype, and ability for continuous multiplication in vitro-all characteristics of 3T3 fibroblasts. A modification e f the target cell surface that results in a high in vitro saturation density, agglutinability by plant lectins, and tumorigenicity appears to evoke a cytotoxic response by activated macrophages.


Thyrotropin and cyclic nucleotide effects on prostaglandin levels in isolated thyroid cells. Thyrotropin increases prostaglandin levels in isolated thyroid cells. Since comparable results were obtained with butyrated cyclic adenosine monophosphate derivatives as well as with the phosphodiesterase inhibitors quazodine and theophylline, it appears that cyclic adenosine monophosphate mediates this effect of thyrotropin. These observations suggest that intracellular prostaglandins play a role in modulating thyrotropin action on thyroid.


Radioreceptor assay for prolactin and other lactogenic hormones. A radioreceptor assay with a sensitivity of 5 nanograms per milliliter has been developed for mammalian and avian pituitary prolactin, placental lactogenic hormones, and humnan growth hormone, using a membrane receptor preparation isolated from rabbit mammary glands. Prolactin preparations inhibited the binding of [(125)I]prolactin to receptors in direct proportion to the biological potency of these preparations. Thus, the radioreceptor assay provides a convenient and simnple assay for hormones which have lactogenic activity.


Effects of deep-sea pressures on microbial enzyme systems.


Chlorphentermine-induced ultrastructural alterations in foetal tissues.


Morphometry of dog liver: normal base-line data.


Genesis of foam cells: study in rats after administration of Cloforex.


Participation of monocytes in transient glomerular hypercellularity in poststreptococcal glomerulonephritis.


In vitro assembly of polioviruses. 3. Assembly of 14 S particles into empty capsids by poliovirus-infected HeLa cell membranes.


HeLa cell nucleolar RNA synthesis after poliovirus infection.


Temperature-sensitive avian sarcoma viruses: a physiological comparison of twenty mutants.


Integration of viral into chromosomal deoxyribonucleic acid in an inducible line of polyoma-transformed cells.


Appearance of virus-specific RNA, virus particles, and cell surface changes in cells rapidly transformed by the murine sarcoma virus.


Measurement of endogenous leukosis virus nucleotide sequences in the DNA of normal avian embryos by RNA-DNA hybridization.


On neural inhibition, contrast effects and visual sensitivity.


Comparison of oligonucleotides produced by RNase T1 digestion of 7 S RNA from avian and murine oncornaviruses and from uninfected cells.


Chemodectoma with distant metastasis: case report and review of the literature.


Experimental study of interactions between pneumoconiosis and mycobacterial infections.


The other side of marihuana research.

The other side of marihuana research.


The role of quartz in the development of coal workers' pneumoconiosis.


Inhalation studies of coal-quartz dust mixture.


The pulmonary response to coal dust.

The pulmonary response to coal dust.


Antagonistic factors in the pathogenesis of coal workers' pneumoconiosis.


Prevalence of coal workers' pneumoconiosis in Yugoslavia.


Factors influencing dust retention in the pulmonary parenchyma.


Coal workers' pneumoconiosis in South Africa.


Relation of lung dust content to radiological changes in coal workers.


Types of fibrosis in coal workers' pneumoconiosis.


Roentgen pathological correlations in coal workers' pneumoconiosis.


Validation of classifications of pneumoconiosis.


Sampling and evaluating respirable coal mine dust.


Treatment of pneumoconiosis caused by coal-quartz dusts with polyvinylpyridine-N-oxide (P 204).


Perspectives in current research for control of airborne dust in coal mines.


Recent advances in the analysis of respirable coal dust for free silica, trace elements, and organic constituents.


Investigative techniques in the laboratory study of coal workers' pneumoconiosis: recent advances at the cellular level.


The physiology of renin.

The physiology of renin.


Liver-cell carcinoma presenting as bile-duct tumour.


Glomus jugulare tumours--radiotherapy or surgery?


Multiple renal silica calculi.

Multiple renal silica calculi. Investigation of a patient with a history of renal colic, who had taken the equivalent of 2 g magnesium trisilicate after every meal for many years, showed that he was forming silica calculi. The nature of the stone was diagnosed only after quantitative analysis.


The denatured states of lysozyme.

The denatured states of lysozyme.


Comparative study of the development of alkaline phosphodiesterase I and alkaline phosphatase in mucosa of rat jejunum and ileum.


Thymidine as one of the factors in a beef liver extract decreasing  3 H-thymidine incorporation into DNA.


Studies on glycogen metabolism in normal and diabetic rat heart in vivo.


Let us stay near our patients.

Let us stay near our patients.


Ribonucleic acid polymerase induced in L-cells infected with vesicular stomatitis virus.


Ultrastructural and biochemical changes in the liver of monkeys given butylated hydroxytoluene and butylated hydroxyanisole.


Hypophysis and function of pancreatic islets. 3. Secretion and biosynthesis of insulin in isolated pancreatic islets of intact and hypophysectomized rats in the presence of growth hormone, corticotrophin and human chorionic somatotrophin in vitro.


Relative eye-injury potential of heavy-duty phosphate and non-phosphate laundry detergents.


Fasting in obese females: plasma renin after glucose refeeding.


Thyroid hormone binding to the anterior pituitary gland.


ACTH inhibition of dehydration-induced changes in the hypothalamic neurosecretory system of the musk shrew, suncus murinus L.


Sero-epidemiology of cytomegalovirus infection in and around Chandigarh (Northern India).


The epidemiology of amoebiasis in an urban area.


Direct amoebicidal action of known antiamoebic drugs against axenically grown Entamoeba histolytica.


Adrenergic neurone blocking actions of procaine and lignocaine.


Nondysenteric intestinal amebiasis. Treatment with diloxanide furoate.


Effect of acute transection on the synthesis and turnover of 5-HT in the rat spinal cord.


Dibutyryl cyclic AMP and adrenaline increase contractile force and  45 Ca uptake in mammalian cardiac muscle.


Effects on shock-elicited aggression in mice of preferentially protecting brain monoamines against the depleting action of reserpine.


Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.


Effects of stress and REM sleep deprivation on the patterns of avoidance learning and brain acetylcholine in the mouse.


Interaction of oxotremorine with atropine, chlorpromazine, cyproheptadine, imipramine and phenoxybenzamine on the flexor reflex of the chronic spinal dog.


Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides. Osmotic release of beta-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.


Endothelial inclusions in congenital infantile nephrosis.


Cellular autophagy and cell atrophy in the rat liver during long-term starvation. A quantitative morphological study with regard to diurnal variations.


The development of cholangiofibrosis and hepatomas in galactosamine induced cirrhotic rat livers.


The primary structure of tRNA trp  from brewer's yeast. I. Complete digestion with pancreatic ribonuclease and T 1  ribonuclease.


The primary structure of tryptophan transfer ribonucleic acid from brewer's yeast. II. Partial digestion with pancreatic ribonuclease and derivation of complete sequence.


Accessibility of Escherichia coli 5S RNA base residues to chemical reagents. Influence of chemical alterations on the affinity of 5S RNA for the 50S subunit structure.


In vivo studies of the possible role of cholesteryl esters as precursors of bile acids.


Retinal embolism after hysterosalpingography.


Ultrastructural observations on the calcification of human dental pulp.


Scanning electron microscopic observations on bone from patients with hypophosphataemic (vitamin D resistant) rickets.


The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals.


Factors affecting the precipitation of calcium phosphate in vitro.


The effects of bacterial collagenase in rabbit vitreous.


The swinging flashlight test in multiphasic screening for eye disease.


Preparation and specificity of antiserum to synthetic secretin and its use in a radioimmunoassay (RIA).


Dissociation of gonadotropin-induced ovulation and steroidogenesis in immature rats.


Incorporation of orthophosphate 32Pi into the phospholipids of slices of gonads, anterior pituitary and liver of calf.


Characteristics of the nuclear RNA polymerase from rat anterior pituitary tissue.


Amoebiasis in pediatric age group.

Amoebiasis in pediatric age group.