Appearance of cytotoxic T cells in cerebrospinal fluid of mice with ectromelia virus-induced meningitis.


Application of spin-labeled vitamin B6 analogues for the study of aspartate aminotransferase.


Applications of kinetic methods to aminoacyl-tRNA synthetases.


Aqueous humour dynamics in ocular hypertension.


Arabinose (fucose) dehydrogenase from pig liver. II. Steady-state kinetics.


Aromatization of testosterone by human placental microsomes under the presence of sex hormone-binding globulin and 17 beta-estradiol.


Arrestovisography, a method for objective assessment of visual acuity. Demonstration of the apparatus.


Ascorbic acid-like effect of the soluble fraction of rat brain on adenosine triphosphatases and its relation to catecholamines and chelating agents.


Aspects of experimental hepatocarcinogenesis. II. Hyperplastic nodules.


Aspects of the blood-aqueous barrier with special reference to the penetration of antibiotics.


Association of herpes simplex type 2 virus with cervical cancer of the uterus.


Association of viral and mycoplasma infections with exacerbations of asthma.


Atypical lymphocytes. Morphologic features.


Automatic determination of the N-terminal sequence of cytochrome C from the insect Ceratitis capitata.


Autoradiography with a position sensitive counter.


Autoradiographic analysis of gonadotropin binding to rat ovarian tissue sections.


Availability of zinc in leavened and unleavened wholemeal wheaten breads as measured by solubility and uptake by rat intestine in vitro.


Axonal degeneration in the sural nerves of cancer patients.


Axonal transport in the retinal ganglion cells of the rabbit under different experimental conditions.


ACTH-induced protein release from the perfused cat adrenal gland: evidence for exocytosis?


Bacteriocin susceptibility of Clostridium perfringens: a provisional typing schema. Ninety-four strains of Clostridium perfringens were examined for bacteriocin production. Bacteriocins produced by ten of these strains were selected for typing 274 cultures of C. perfringens. The bacteriocins were prepared by growing the producer strains in broth and precipitating the active principle from the supernatant fluids of centrifuged cultures with ammonium sulfate. All bacteriocins were titrated against a common indicator strain, adjusted to equivalent titers, and spotted onto blood agar plates seeded with the test organisms. Fifty different bacteriocin sensitivity patterns were observed. These patterns were organized into seven groups bearing some relationship, and the largest number of strains falling into any one pattern did not exceed 16% of the total strains tested. Ninety-nine percent of all isolates were typable. The new method should prove useful in studies where strains must be fingerprinted.


Bacitracin biosynthesis by three complementary fractions from Bacillus licheniformis.


Baro- and chemoreceptor mechanisms in haemorrhage.


Basis for the selectivity of action of the polymyxin antibiotics on cell membranes.


Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.


Binding of acetylcholine and cholinergic drugs to proteolipid fractions from rat cerebral cortex and to phospholipids from bovine brain.


Binding of heparin in vitro and in vivo to plasma proteins.


Binding of thyroid stimulators to thyroid membranes.


Binding of UGA to wild type and suppressor tryptophan tRNA from E. coli.


Bioassay of oxytocin on the superfused mammary gland of the mouse, using an automatic apparatus. 1 A sensitive method of assaying oxytocin using the superfused mouse mammary gland is described. The method is shown to be reliable, accurate and precise. Assays are performed automatically and the preparation is stable for at least 18 hours.2 The preparation is relatively insensitive to bradykinin, histamine, 5-hydroxytryptamine, angiotensin, prostaglandin F(2alpha), adrenaline and noradrenaline. The contractions produced by acetylcholine can be abolished by atropine without the sensitivity to oxytocin being affected.3 Vasopressin has a variable activity on the preparation; its potency can be as high as one-fifth that of oxytocin.4 It is concluded that this method compares favourably with other published methods.


Biogenic amines and affective disorders.


Biochemical effects of ellipticine on leukemia L1210 cells.


Biosynthesis of membrane teichoic acid: role of the D-alanine-activating enzyme and D-alanine: membrane acceptor ligase.


Biosynthesis of valinomycin.

Biosynthesis of valinomycin.


Biosynthesis of water-soluble vitamins.

Biosynthesis of water-soluble vitamins.


Blood volume of adult germfree and conventional rats.


Biosynthesis, physiologic role and normal patterns of lipoproteins in normal human plasma.


Bluetongue and related viruses in Ibadan, Nigeria: serologic comparison of bluetongue, epizootic hemorrhagic disease of deer, and Abadina (Palyam) viral isolates.


Bluetongue and related viruses in Ibadan, Nigeria: serologic studies of domesticated and wild animals.


Bone marrow and thymus regeneration is a condition for thymoma development.


Brain stem encephalitic lesions and schizophrenia. A report of 3 cases.


Calcinosis.

Calcinosis.


Can benign lymphadenosis (lymphomatosis) of the orbit occasionally be a paraneoplasia?


Calcium-binding phosphoprotein from pig brain: identification as a calcium-dependent regulator of brain cyclic nucleotide phosphodiesterase.


Canine herpesvirus infection: literature review and case report.


Carbohydrate metabolism in rat uterus during the oestrous cycle.


Carbohydrate metabolism in shock resistance.


Canrenoate in normal man.

Canrenoate in normal man.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-1974.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-1974.


Ca2+-induced lateral phase separations in phosphatidic acid-phosphatidylcholine membranes.


Cell fusion by the antigen-antibody complex of Sendai virus studied by electron microscopy.


Cell surface glycolipid and glycoprotein glycosyltransferases of normal and transformed cells.


Cell surface immunoglobulin. VI. Dynamics on a human lymphoma line.


Cell transformation mutants are not susceptible to growth activation by fibroblast growth factor at permissive temperatures.


Central nervous influence upon the adrenocortical reaction during stress situations.


Cerebral scintigraphy with a Nuclear Chicago 1206 high performance gamma camera.


Carcinoma complicating a benign teratoma of the rectum: Report of a case.


Changes in plasma corticosterone and hypothalamic CRF levels following intraventricular injection or drug-induced changes of brain biogenic amines in the rat.


Characteristics of vesicular stomatitis virus envelopes released with saponin.


Characterization of a novel nicotinamide adenine dinucleotide-dependent alcohol dehydrogenase from a strain of Streptococcus mutans.


Cellular action of antidiuretic hormone in mice with inherited vasopressin-resistant urinary concentrating defects. Previous work has suggested that resistance to vasopressin in two strains of mice with nephrogenic deficiency of urinary concentration may entail a defect in the action of vasopressin at the cellular level. Several components involved in this action were therefore examined in vitro in renal medullary tissues from control mice (genotype VII +/+) and two genotypes with mild diabetes insipidus (DI +/+ nonsevere) and marked (DI +/+ severe) vasopressin-resistant concentrating defects. No significant differences were found in the affinity of adenylate cyclase for [8-arginine]-vasopressin (AVP), tested over a range of hormone concentration from 10(-10) to 10(-5) M. However, maximal stimulation of adenylate cyclase by saturating concentrations of AVP (intrinsic activity) was markedly decreased from control values in DI +/+ severe mice, and decreased to a lesser extent in DI +/+ nonsevere animals. A significant correlation was found between the activity of adenylate cyclase maximally stimulated by AVP in a given genotype, and the urine osmolality in the same animals. There were no significant differences in maximal stimulation of renal medullary adenylate cyclase in control experiments: not when stimulated nonspecifically by sodium fluoride, nor when stimulated by AVP in tissues from rats with induced water diuresis as compared to antidiuretic rats. Nor were there significant differences between VII +/+ and DI +/+ severe mice in the activity of renal cortical adenylate cyclase, either basal or when stimulated by parathyroid hormone. Furthermore, the abnormal genotypes did not differ significantly from control mice in the renal medullary activities of cyclic AMP phosphodiesterase or cyclic AMP-dependent protein kinase, nor in the content of microtubular subunits (assessed as colchicinebinding protein). The results are compatible with the view that impaired stimulation of renal medullary adenylate cyclase by vasopressin might be the sole or contributing cause of the vasopressin-resistant concentrating defect in the diseased mice; however, a causal relationship has not yet been proved.


Characterization of protein kinases forming acid-labile histone phosphates in Walker-256 carcinosarcoma cell nuclei.


Characterization of bromodeoxyuridine-induced endogenous guinea pig virus. An endogenous virus (GPV) was induced after 5-bromodeoxyuridine treatment of cultured guinea pig cells. Compared to Gross murine leukemia virus (G-MuLV) GPV has a reproducibly heterogenous density of about 1.16 to 1.18 g/ml. The virion-associated RNA is slightly larger than that in G-MuLV. Sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of dissociated GPV resolved five major structural proteins: I (molecular weight 70,000), II (molecular weight 36,000), III (molecular weight 24,000), IV (molecular weight 18,000), and V (molecular weight 16,000) which are similar to but distinct from G-MuLV proteins. Proteins I and II were demonstrated to be glycoproteins by incorporation of [(3)H]glucosamine. GPV and G-MuLV did not have any appreciable genetic homology or any common group-specific antigens when analyzed by immunodiffusion, radioimmunoassay, and indirect immunofluorescence. Morphogenesis of GPV also differed from that of a typical type C oncornavirus and proceeded via two pathways: (i) a majority of virus particles were formed in cytoplasmic vacuoles and were released after cellular disruption; and (ii) a minor population of particles were assembled in the cytoplasmic matrix and then migrated to the plasma membrane where they budded into the extracellular space. To date, GPV has been unable to initiate or maintain a productive replication in any cell line tested.


Characterization of lactose-fermenting revertants from lactose-negative Streptococcus lactis C2 mutants. Partial lactose-fermenting revertants from lactose-negative (lac(-)) mutants of Streptococcus lactis C2 appeared on a lawn of lac(-) cells after 3 to 5 days of incubation at 25 C. The revertants grew slowly on lactose with a growth response similar to that for cryptic cells. In contrast to lac(+)S. lactis C2, the revertants were defective in the accumulation of [(14)C]thiomethyl-beta-d-galactoside, indicating that they were devoid of a transport system. Hydrolysis of o-nitrophenyl-beta-d-galactoside-6-phosphate by toluene-treated cells confirmed the presence of phospho-beta-d-galactosidase (P-beta-gal) in the revertant. However, this enzyme was induced only when the cells were grown in the presence of lactose; galactose was not an inducer. In lac(+)S. lactis C2, enzyme induction occurred in lactose- or galactose-grown cells. The revertants were defective in EII-lactose and FIII-lactose of the phosphoenolpyruvate-dependent phosphotransferase system. Galactokinase activity was detected in cell extracts of lac(+)S. lactis C2, but the activity was 9 to 13 times higher in extracts from the revertant and lac(-), respectively. This suggested that the lac(-) and the revertants use the Leloir pathway for galactose metabolism and that galactose-1-phosphate rather than galactose-6-phosphate was being formed. This may explain why lactose, but not galactose, induced P-beta-gal in the revertants. Because the revertant was unable to form galactose-6-phosphate, induction could not occur. This compound would be formed on hydrolysis of lactose phosphate. The data also indicate that galactose-6-phosphate may serve not only as an inducer of the lactose genes in S. lactis C2, but also as a repressor of the Leloir pathway for galactose metabolism.


Characterization of slowly interconvertible states of phosphoribosyladenosine triphosphate synthetase dependent on temperature, substrates, and histidine.


Chemical and physico-chemical alterations of human erythrocytes by periodate, succinic anhydride, 2-phenylethanol, and 1,1-dimethylphenylethanol: effects on membrane permeability and on metabolism of intact cells and hemolysates.


Chemical and biological evolution of nucleotide-binding protein.


Chemical determination of oestrogen distribution in the foetus and placenta of the domestic pig.


Chemotherapy in intraocular metastasis from carcinoma of the breast.


Children's mental health services: a case study of a successful grant proposal.


Chinese hamster hypoxanthine-guanine phosphoribosyltransferase. Purification, structural, and catalytic properties.


Chloroquine-induced ultrastructural changes in the pigment epithelium of the albino rat.


Cholangiofibrosis induced by short-term feeding of 3'-methyl-4-(dimethylamino)azobenzene: an electron microscopic observation.


Cholinergic stimulation of phospholipid labelling from (32P) orthophosphate in guinea-pig cortex synaptosomes in vitro: subsynaptosomal localization.


Chromatographic changes in specific tRNAs after reaction with cyanogen bromide and sodium periodate.


Chromatin-associated DNA endonuclease activities in HeLa cells.


Chronic cyclitis in children.

Chronic cyclitis in children.


Circular dichroism spectra of DNA of high adenine plus thymine content.


Circular dichroism of DNA in the vacuum ultraviolet.


Cleavage of 23-S RNA in 50-S ribosomes into a 5'-terminal and a 3'-terminal fragment by pancreatic ribonuclease.


Clinical and pathological effects of streptozotocin.


Clinical evaluation of endolymphatic radiotherapy in malignant lymphoma.


Clinical immunology and the physician. Blood.


Chronic aggressive hepatitis. Report of a case with virus like particles in the liver.


Clinical significance of circulating hormonal substances.


Cold agglutinin production and cytomegalovirus infection.


Clusters in lipid bilayers and the interpretation of thermal effects in biological membranes.


Collagenases (first of three parts).

Collagenases (first of three parts).


Collagenases (second of three parts).

Collagenases (second of three parts).


Collagenases (third of three parts).

Collagenases (third of three parts).


Comparative effects of prostaglandins A2 and B2 on vascular and airway resistances and adrenergic neurotransmission.


Combined use of 99mtechnetium-labelled macroaggregates of albumin and 75selenium-selenomethionine in the diagnosis of lung cancer.


Clinical disorders of sleep.

Clinical disorders of sleep.


Comparison between different techniques of immuno-protection in the A-SW mouse-SEWA tumour system. Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obtained. The results, when allogeneic hybrid or xenogeneic cells were used, were comparable with those obtained for polyoma virus. This indicates that the T.A.T.A. of the SEWA tumour had been well conserved. When polyoma virus alone was used as the protector agent, injection 7 days before the tumour challenge, or iterative injection, afforded better protection than a single injection on the day of challenge.


Comparison between the effect of luteinizing hormone and prostaglandin E1 on ovarian cyclic AMP.


Colitis cystica profunda, an unusual solitary tumor: Report of three cases.


Comparison of actions of papaverine, aspaminol and isoprenaline on isolated rat uterus.


Comparison of analysis of isoniazid and its dosage forms by several methods.


Comparison of immunoglobulin formation in vitro by leukocytes of normal donors and steroid- and nonsteroid-treated asthmatic patients.


Comparison of somatic mutation rates induced in Tradescantia by chemical and physical mutagens.


Comparison of the properties of glucosaminephosphate isomerase (glutamine-forming) from rat liver and a hepatoma.


Compartmentalization of murein hydrolases in the envelope of Escherichia coli.


Comparison of the presynaptic actions of botulinum toxin and beta-bungarotoxin on neuromuscular transmission.


Comparative studies on mitochondrial development in yeasts. 3. Growth-phasic effects of antibiotics on mitochondrial differentiation in Candida.


Concentration of amino acids in aqueous humour and plasma in congenital cataract or dislocation of the lens.


Conformation changes in cytochrome c2 from Rhodospirillum rubrum.


Conformation of cyclic beta-adenosine 3',5'-phosphate in solution using the lanthanide shift technique.


Conformational differences in myosin. Evidence for change in rate limiting step of the magnesium stimulated ITPase of myosin.


Consideration of potential parasite food hazards.


Conjugated estrogen therapy and tests of thyroid function.


Constant occurrence of adrenocortical tissue in the juvenile rabbit ovary.


Control of membrane lipid fluidity in Acholeplasma laidlawii.


Corneal reflection of a straight line and ophthalmometry in normal people and in asymptomatic relatives of patients with keratoconus. A preliminary report.


Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease.


Cortisol induction of glycerol phosphate dehydrogenase in a rat brain tumour cell line.


Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa. In Neurospora crassa, histidine starvation of histidine mutants resulted in derepression of histidine, tryptophan, and arginine biosynthetic enzymes. The same tripartite derepression occurred in wild-type strain 74A when it was grown in medium supplemented with 3-amino-1,2,4-triazole, an inhibitor of histidine biosynthesis. Histidine-mediated derepression of tryptophan and arginine biosynthetic enzymes was not due to a lowered intracellular concentration of tryptophan or arginine, respectively. A discussion of possible mechanisms and of similar studies in prokaryotic and eukaryotic organisms is presented.


Cryptic A-like receptor sites in human erythrocyte glycoproteins: proposed nature of Tn-antigen.


Cultivation of Entamoeba histolytica with bacterial associates. Isolation and maintenance of Taiwan strains.


Cross-pathway regulation: tryptophan-mediated control of histidine and arginine biosynthetic enzymes in Neurospora crassa. In Neurospora crassa, the starvation of tryptophan mutants for tryptophan resulted in the derepression of tryptophan, histidine, and arginine biosynthetic enzymes. This tryptophan-mediated derepression of histidine and arginine biosynthetic enzymes occurred despite the fact that the tryptophan-starved cells had a higher intracellular concentration of histidine and arginine than did nonstarved cells.


Cutting the REM nerve: an approach to the adaptive role of REM sleep.


Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. The major limitation to our understanding of the clinical importance of enterotoxigenic Escherichia coli in diarrheal illness has been the lack of a simple rapid assay for the enterotoxin produced by certain E. coli. On the basis of the activation of adenylate cyclase by heat-labile enterotoxin of E. coli (LT) and by cholera toxin (CT) in intestinal and other tissues, cultured Chinese hamster ovary (CHO) cells with known morphological responses to dibutyryl cyclic adenosine 5'-monophosphate (AMP) were exposed to these enterotoxins. Crude culture filtrates of LT-producing E. coli and CT stimulated cyclic AMP accumulation and cell elongation in CHO cells. The similarity of time course, concentration dependence, and potentiation by phosphodiesterase inhibitors suggested cyclic AMP mediation of the morphological change. Heat inactivated CT and LT in this system. Choleragenoid inhibited CT; antiserum against CT inhibited both enterotoxin effects. In contrast to culture filtrates of 16 strains of E. coli known to produce LT, culture filtrates from 13 E. coli that do not produce LT did not alter CHO cell morphology. The morphological change is a simple, specific assay for these enterotoxins and detect 3 x 10(-17) mol of CT or a 1:250 dilution of crude culture filtrate of LT-producing E. coli 334.


Cyclic adenosine 3':5'-monophosphate metabolism in normal and SV40-transformed WI-38 cells.


Cyclic guanosine 3':5'-monophosphate in Escherichia coli and Bacillus lichenformis.


Cyclic guanosine-3':5'-monophosphate induced diuresis in rats.


Cyclic nucleotides in higher plants?

Cyclic nucleotides in higher plants?


Cyclic nucleotide levels during spontaneous uterine contractions.


Cyclic AMP and the immune response;.

Cyclic AMP and the immune response;.


Cyclic AMP and the transformation of fibroblasts.


Cyclic AMP and the triggering of the decidual reaction.


Cytochalasin B: aspects of phagocytosis in nutrient uptake in Tetrahymena.


Cytarabine treatment of progressive multifocal leukoencephalopathy. Clinical course and detection of virus-like particles after antiviral chemotherapy.


Cytochrome c peroxidase catalyzed oxidation of ferrocyanide by hydrogen peroxide. Steady-state kinetics.


Cytochrome c peroxidase catalyzed oxidation of ferrocyanide by hydrogen peroxide. Transient state kinetics.


Cytochrome c: a thermodynamic study of the relationship among oxidation state, ion-binding and structural parameters. Cation binding to horse-heart ferrocytochrome c.


Cytochrome P450 associated with free hepatic polyribosomes.


Cytosol-binding protein of thyroxine and triiodothyronine in human and rat kidney tissue.


D(-)-beta-hydroxybutyrate dehydrogenase activity in cloned cell lines of glial and neuronal origin.


Demodicosis in the Mongolian gerbil (Meriones unguiculatus): a case report.


Demonstration of alpha-Fetoglobulin in hepatoma tissue by fluorescent antibody technique.


Demonstration of protease-like activity in human serum low density lipoprotein.


Cyclic AMP and anxiety.

Cyclic AMP and anxiety.


Deoxyglucose transport changes in murine sarcoma virus-infected cells-a quantitative assay for virus transforming activity.


Design consideration for long-acting antagonists.


Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in purified Chlamydia trachomatis initial bodies.


Detection of antibodies against virally-induced tumor-associated antigens by mixed hemadsorption.


Detection of cardiac damage using a steady state assay for lactate dehydrogenase isoenzymes in serum.


Death and dying--oncology discussion group.


Detection of tumor-virus associated antibodies by mixed hemadsorption.


Determination of glycerol dehydratase activity by the coupled enzymic method.


Detection of Epstein-Barr virus (EBV)-associated nuclear antigen in human lymphoblastoid cell lines by means of an 125-I-IgG-binding assay.


Determination of the absolute hand of the helix in the nucleocapsid of haemagglutinating virus (Japan).


Determination of the age of some anopheline mosquitos by daily growth layers of skeletal apodemes. Earlier work has shown that it is possible to determine the calendar age of Culex and Aedes mosquitos by counting the daily layers of cuticular growth on the inner apodemes. In view of the epidemiological importance of age grouping in Anopheles species, the applicability of the method to this genus was studied in both laboratory-reared and field-collected specimens. In the four species examined, it was found possible to distinguish daily growth layers for periods of up to 10-13 days provided that proper staining procedures are used.


Density changes in herpesvirus-infected cells.


Determination of the catalytically active unit of fructose 1,6-diphosphatase from rabbit liver.


Determination of the vanadium content of protein solutions by electron paramagnetic resonance spectroscopy.


Development of an inexpensive cell culture medium for the production of foot-and-mouth disease vaccine.


Development of Periplaneta americana (L.) cell cultures and their infection with enteroviruses.


Development of methods for detecting viruses in solid waste landfill leachates. Methods were developed for detecting and concentrating enteric viruses in municipal solid waste landfill leachates. Poliovirus added to a leachate was not readily detectable, possibly because the virus was adsorbed to the leachate particulates. The masking effects associated with suspended solids in the leachate were overcome by adding a final 0.1 M sodium (tetra)ethylenediaminetetraacetate concentration to the leachate. A sodium (tetra)ethylenediaminetetraacetate-treated leachate could be clarified by filtration at pH 8.0 without a loss of virus. The clarified and sodium (tetra)ethylenediaminetetraacetate-treated leachate contained interfering materials of an anionic nature which prevented virus adsorption to epoxy-fiber glass filters. This interfering effect was overcome by treating the leachate with an anion-exchange resin. Viruses in the resin-treated leachate were concentrated by adjusting the leachate to pH 3.5, adding AlCl(3) to a final 0.005 M concentration, adsorbing the viruses to an epoxy-fiber glass virus adsorbent, and eluting the adsorbed viruses in a small volume. When this method was used to concentrate poliovirus 100-fold in a variety of leachates, the average virus recovery efficiency was 37%. With the methods described in this study, it should be possible to efficiently monitor solid waste disposal site leachates for enteric viruses.


Developmental changes of steryl esters in normal and jimpy mouse brain.


Developments in monitoring human populations for mutation rates.


Diagnosis of recent Herpes simplex infections. A modified immunofluorescent test for the detection of specific Herpes simplex IgM antibodies after staphylococcal adsorption of IgG.


Dielectric measurements of Nitellopsis obtusa cells with intracellular electrodes.


Differential effects of Mg2+ on various hydrolytic and synthetic activities of multifunctional glucose-6-phosphatase.


Differential properties of prostaglandin and gonadotropin receptors in the bovine corpus lutuem cell membranes.


Differentiation of type A foot-and-mouth disease virus subtypes by double- and radial-immunodiffusion analysis.


Differential spermatogenic response of mice to the induction of mutations by antineoplastic drugs.


Diguanosinetetraphosphate guanylohydrolase in Artemia salina.


Diphenylhydantoin treatment of glycogen storage diseases.


Distribution and some properties of acid phosphatase in the 7,12-dimethylbenz(alpha) anthracene-induced rat-mammary carcinoma.


Disturbances of the hypothalamo-hypophysial-adrenocortical system in the alloxan diabetic rat.


Divergent synaptic influences affecting discharge patterning of genioglossus motor units.


Dopamine-beta-hydroxylase activity in cholinergic neuroblastoma times glioma hybrid cells; increase of activity by N6,O2'-dibutyryl adenosine 3':5'-cyclic monophosphate.


Dopamine-induced inhibition of synaptic transmission in the inferior mesenteric ganglion of the dog.


Dose response analysis of 0.1 per cent, 0.5 per cent, 1.0 per cent, and 2.0 per cent epinephrine in chronic open-angle glaucoma.


Duck viral enteritis: microtiter plate isolation and neutralization test using the duck embryo fibroblast cell line.


Drinking induced by injections of angiotensin into forebrain and mid-brain sites of the monkey. 1. Unilateral and bilateral injections of 1.0 mul. solutions of angiotensin II into specific brain sites produced copious drinking of water in the water-replete rhesus monkey (Macaca mulatta).2. Of six brain regions in seven monkeys into which a total of 368 microinjections of angiotensin II were made, three were sensitive to angiotensin II. In decreasing order of sensitivity, they were (i) a rostral zone that included the septum, the anterior hypothalamus and the preoptic region, (ii) a caudal zone consisting of the mesencephalic central grey, and (iii) the lateral and third ventricles near the foramen of Monro. Of the regions tested, those that were relatively inactive included (i) the mid line thalmus, (ii) the mid-brain reticular formation, and (iii) metencephalic points in the cerebellum, the 4th ventricle and the dorsal aspect of the pons.3. Bilateral microinjections of angiotensin II into the sensitive regions in doses as low as 0.75-6 ng were dipsogenic and, with increasing doses, drinking occurred in a dose-dependent fashion up to 500 ng, after which the amount drunk levelled off or was reduced. The dose-response curve for unilateral microinjections began at 12.5 ng, and at doses higher than 50 ng unilateral and bilateral microinjections were equipotent.4. The onset of drinking (without eating) averaged 2.1-3.2 min following the end of microinjections for all sensitive tissue sites. Injections into the ventricles produced significantly longer drinking latencies.5. Angiotensin I elicited drinking in amounts comparable to angiotensin II at a dose of 100 ng whereas analogues of angiotensin II were weak dipsogens. Of the three analogues tested, Phe(4), Tyr(8)-angiotensin II was the most potent dipsogen, followed by Ile(8)-angiotensin II. The 1-7 heptapeptide, des-Phe(8)-angiotensin II was an ineffective dipsogen. Carbachol microinjected into the most sensitive angiotensin drinking sites had no dipsogenic action in the water-replete monkey.6. Tachyphylaxis to angiotensin II was demonstrated as a reduction in mean water intake of 55 and 74 per cent on the second and third microinjections, respectively. This reduction appeared to be due to dilutional inhibition or signals from the amount of water ingested on the first microinjection of angiotensin II.7. Monkeys drank an amount equal to a normal daily intake following two to three microinjections of angiotensin II in doses of 100-250 ng into sensitive regions. This extra water load caused no reductions in normal daily water intake either for the remainder of the experimental day or 24 hr later.8. Pre-treatments with microinjections of an angiotensin-converting enzyme inhibitor, SQ 20,881, did not reduce the dipsogenic action of angiotensin I, suggesting that this and perhaps other peptide precursors act directly on receptor mechanisms to produce drinking. Attempts to change the polydipsic effects of angiotensin II were unsuccessful with pre-treatments of intracranial microinjections of either haloperidol, Ile(8)-angiotensin II or carbachol.9. Microinjections of angiotensin II dissolved in hypertonic saline solutions had no influence on water intake when compared with the same dose dissolved in distilled water or isotonic saline.10. Yawning was the only other response that appeared to be related directly to intracranial injections of angiotensin II. In some instances, a hyperactive state of the animal followed intraventricular injections of angiotensin II. In other instances, intracranial microinjections of angiotensin II were followed by quietude or e.e.g. and behavioural signs of light sleep.11. This work further confirms the findings of previous research which showed that angiotensin II is the most potent dipsogen in all species tested to date. This endogenous peptide appears to participate in natural thirst by acting on central mechanisms of extracellular thirst.


Duodenal calcium binding protein in the chick: a new bioassay for vitamin D.


Dynamics of cyclic adenosine 3',5'-monophosphate release during adrenocortical stimulation in vivo.


Dyskeratotic marginal keratoconjunctivitis in hereditary periodontopathy and hyperkeratosis.


Dyslipoproteinemias and diabetes mellitus.


Ecological survey by the immunofluorescent method of virus in enzootics of avian encephalomyelitis.


Editorial: Burkitt's lymphoma;.

Editorial: Burkitt's lymphoma;.


Editorial: New concepts in adipose tissue metabolism and obesity.


Editorial: The endogenous factor in intestinal calcium absorption.


Effect of aging on renal membrane-bound enzyme activities.


Effect of carbachol on amino acid incorporation into protein of rat pancreas in vitro.


Effect of chemical mediators on the K+-efflux, Ca2+-uptake and 32P-incorporation of erythrocytes.


Effect of chloroquine on acid phosphatase activity in the pigment epithelium of the retina of albino and pigmented rats.


Effect of chlorpropamide on cyclic AMP in rat renal medulla.


Effect of cyclopentolate on the aqueous dynamics in incipient or suspected open-angle glaucoma.


Effect of cyclophosphamide on ACTH-induced kidney disease.


Effect of drugs on the activity of thrombocytes 3,5-cyclic AMP phosphodiesterase.


Effect of estradiol on lipolysis and adenosine 3',5'-monophosphate accumulation in isolated rat adipocytes.


Effect of extracellular chondroitin sulfate on cultured chondrocytes.


Effect of flavin adenine dinucleotide on the glucose-6-phosphate dehydrogenase activity of adrenal gland of hypophysectomized rats.


Effect of fusidic acid on sporulation of Bacillus subtilis.


Effect of glucagon, epinephrine, cyclic 3',5'-AMP, N6-2'-0-dibutyryl cyclic 3',5'-AMP and insulin upon the phosphate exchange of the isolated perfused fed rat liver.


Effect of glycine and serine in synthetic amino acid diets upon glycine and serine metabolism in chicks.


Effect of hypervitaminosis A on the testes of the rat during lactation.


Effect of induced hypothyroidism on pituitary luteinizing hormone (LH) concentration in female rats.


Effect of immunisation with heat-killed micro-organisms on transplantation immunity to adenovirus-12-induced tumour cells.


Effect of isoproterenol on blood pressure, plasma renin activity, and water intake in rats.


Effect of inhibitors of ribonucleic acid and protein synthesis on the cyclic adenosine monophosphate stimulation of plasmid ColE1 replication. Addition of cyclic adenosine 3'-5'-monophosphate (c-AMP) to growing Escherichia coli cells, colicinogenic for the plasmid ColE1, results in a fourfold stimulation in the rate of synthesis of the plasmid deoxyribonucleic acid (DNA). The stimulation is transient (30 min) and is succeeded by a brief period (30 min) of cessation of plasmid DNA replication. The stimulation of ColE1 DNA replication also occurs in chloramphenicol-treated cells. Rifampin inhibits ColE1 DNA replication in the presence or absence of c-AMP. Employing thymine starvation conditions to stop ColE1 DNA synthesis, it was found that c-AMP, added during the period of thymine starvation, effected a stimulation in the amount of subsequent replication which took place when replicating conditions were restored. The stimulatory effect of c-AMP under these conditions was not prevented by chloramphenicol but was completely eliminated when rifampin was present. Under these conditions, when rifampin was added after the effect of c-AMP was allowed to occur, subsequent replication of the plasmid could take place, but only one round of replication occurred. A model to account for the c-AMP effects is presented.


Effect of paracentesis on ocular antibiotic concentration.


Effect of phenformin on lipid transport in hypertriglyceridemia.


Effect of phospholipase C on the permeability of the toad bladder.


Effect of potassium sorbate on salmonellae, Staphylococcus aureus, Clostridium perfringens, and Clostridium botulinum in cooked, uncured sausage. Skinless precooked, uncured sausage links with and without potassium sorbate (0.1% wt/wt) were inoculated with salmonellae, Staphylococcus aureus, Clostridium perfringens, and Clostridium botulinum and held at 27 C to represent temperature abuse of the product. Total counts of uninoculated product showed that the normal spoilage flora was delayed 1 day when sorbate was present. Growth of salmonellae was markedly retarded by sorbate. Growth of S. aureus was delayed 1 day in the presence of sorbate, after which growth occurred to the same level as in product without sorbate. C. perfringens declined to below detectable levels within the first day in product with and without sorbate. Sorbate retarded the growth of C. botulinum. Botulinal toxin was detected in 4 days in product without sorbate but not until after 10 days in product with sorbate.


Effect of short-term increased intraocular pressure on the fine structure of the retina.


Effect of schistosomal infection and of schistosomicidal drugs on the drug metabolizing enzymes of mouse liver.


Effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets.


Effect of vasoconstrictors on lymph oxygen tension in normo- and hypovolemia.


Effect of stretching on the elastic characteristics and the contractile component of frog striated muscle. 1. The force-velocity relationship and the stress-strain curve of the so-called series elastic component (s.e.c.) of frog sartorius, semitendinosus and gastrocnemius have been determined during shortening against a given force (isotonic quick-release) and at high speed (controlled release): (a) from a state of isometric contraction and (b) after stretching of the contracted muscle. In both cases the muscle was released from the same length: this was usually slightly greater than the muscle's resting length.2. The muscle released immediately after being stretched is able to shorten against a constant force, P, equal to or even greater than the isometric force, P(0), at the same length. When the force P applied to the muscle is reduced below P(0) the velocity of shortening is greater after stretching, and the force-velocity curve is therefore shifted along the velocity axis: the shift is maximal when P is near to P(0) and it decreases rapidly with decreasing P.3. The extent of shortening of the s.e.c. required to make the force fall from P(0) to zero is 50-100% greater when the muscle is released immediately after stretching than when it is released from a state of isometric contraction. This difference is found by using either the controlled release method or the isotonic quick-release method.4. If a time interval is left between the end of stretching and the onset of shortening of the contracted muscle (controlled release method), the length change of the s.e.c., for a given fall of the force, is reduced and approaches that taking place when the muscle is released from a state of isometric contraction.5. Curare does not affect the results described above, indicating that these do not depend on modification of the neuromuscular transmission.6. It is concluded that stretching a contracted muscle modifies temporarily: (a) its elastic characteristics, as shown by the greater amount of mechanical energy released for a given fall of the force at the muscle's extremities, and (b) its contractile machinery, as it is suggested by the change of the force-velocity relationship.


Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species.


Effect of 2'-deoxythymidine on experimental herpes infection.


Effect on growth and structure of transplantable malignant melanomas of the Syrian golden hamster (Mesocricetus auratus) by depletion of phenylalanine and tyrosine in the diet and by inhibition of tyrosinase. Brief report.


Effects of acetylcholine on incorporation of (14C)glucose into phosphatidylinositol and on phosphatidylinositol breakdown in subcellular fractions from cerebral cortex.


Effects of adrenalectomy and corticosterone on thyroid weight of goitrogen-treated rats. Role of adrenal-corticoids in the insulin increase of goitre weight.


Effects of alcohols on the autoxidation of cytochrome c-1.


Effects of cyclic adenosine nucleotides on fluid absorption by different segments of proximal tubule.


Effects of dopamine-like drugs on rat striatal adenyl cyclase have implications for CNS dopamine receptor topography.


Effects of demethylchlortetracycline on cellular action of antidiuretic hormone in vitro.


Effects of ethanol, methanol and different antibiotics on the ATPase and GTPase activities associated with B. stearothermophilus 5 S RNS- protein complex.


Effects of halothane and other anesthetic agents on the concentrations of rat liver metabolites in vivo.


Effects of hypophysectomy and TSH replacement on the ultrastructural localization of thyroperoxidase.


Effects of ovine luteinizing hormone and porcine adrenocorticotropin on maturation of oocytes of the catfish, Heteropneustes fossilis (Bloch), in ovary-interrenal coculture.


Effects of morphine on kinetics of 14C-dopamine in rat striatal slices.


Effects of photo-oxidation on the catalytic and regulatory properties of citrate synthase from Acinetobacter lwoffi.


Effects of pyrazole on ethanol-induced changes in hepatic triglyceride and glycerol-1-phosphate contents and on esterified and non-esterified fatty acids in the blood.


Effects of succinyl-con A on the growth of normal and transformed cells.


Effects of theophylline and propranolol on acetylcholine-induced release of adrenal medullary catecholamines.


Effects of thyroid hormone deficiency on cyclic adenosine 3':5'-monophosphate and control of lipolysis in fat cells.


Effects of ACTH on the sleep of normal subjects and patients with Addison's disease.


Electro-oculography: a clinical normal case series.


Electrocorticogram and behavioral correlates during the development of chronic cobalt experimental epilepsy in the rat.


Electron microscopical studies of the acetylcholinesterase-positive and -negative nerve fibres in the ciliary body of the albino rat.


Electro-optical system for monitoring activity of heart cells in culture: application to the study of several drugs and scorpion toxins.


Electron microscopic observations on postnatal development of the X zone in mouse adrenal cortex.


Electron microscopy as a supplement in the diagnosis of glomus jugulare tumor.


Electron microscopy of the lung in experimental Toxocara canis infection.


Electron spin resonance spectrometry on the whole mouse in vivo: a 100 MHZ spectrometer.


Electron paramagnetic resonance study of the interaction of a spin-labeled analog of adenosine diphosphoribose with paramagnetic cobalt(II) liver alcohol dehydrogenase.


Electron microscopy of young Candida albicans chlamydospores. One- to three-day-old cultures of Candida albicans bearing chlamydospores were grown and harvested by a special technique, free of agar, and prepared for ultramicrotomy and electron microscopy. These young chlamydospores exhibited a subcellular structure similar to that of the yeast phase, e.g., cytoplasmic membrane, ribosomes, and mitochondria. Other structural characteristics unique to chlamydospores were a very thick, layered cell wall, the outer layer of which was continuous with the outer layer of the suspensor cell wall and was covered by hair-like projections; membrane bound organelles; and large lipoid inclusions. Only young chlamydospores less than 3 to 4 days old exhibited these ultrastructural characteristics.


Electron spin resonance studies of free radicals in solution. 3. pH dependence of thiyl free radical of cysteine.


Electron spin resonance studies on diol dehydrase. 3. Rapid kinetic studies on the rate of formation of radicals in the reaction with propanediol.


Electron transport phosphorylation.

Electron transport phosphorylation.


Electron-paramagnetic-resonance studies on nitrogenase. Investigation of the oxidation-reduction behaviour of azoferredoxin and molybdoferredoxin with potentiometric and rapid-freeze techniques.


Electron-paramagnetic-resonance study of manganese ions bound to concanavalin A.


Elongation factor T-dependent GTP hydrolysis: dissociation from aminoacyl-tRNA binding.


Elongation factor 2. Amino acid sequence at the site of adenosine diphosphate ribosylation.


Encephalomyocarditis virus infection of mouse plasmacytoma cells. I. Inhibition of cellular protein synthesis. Mouse plasmacytoma ascites tumor cells (MOPC 460) were efficiently infected with encephalomyocarditis virus. Inhibition of host protein synthesis was evident after 2 h and complete by 4 h postinfection. The mechanism by which virus infection results in inhibition of host cell protein synthesis was studied in vitro. Cell-free protein-synthesizing systems, prepared from uninfected and infected cells, were found to be equally active with respect to their abilities to translate cellular and viral mRNAs. The plasmacytoma cell-free system was also shown to be insensitive to the addition of double-stranded viral RNA. Host cellular mRNA was isolated from uninfected and infected cells. No difference in the amount or size distribution of the mRNA was detected. However, the mRNA from infected cells was translated only 46 to 49% as actively as that from uninfected cells. mRNA isolated from cells in which initiation of protein synthesis was inhibited with pactamycin was similarly inactivated. Simultaneous addition of viral RNA and cellular mRNA to the plasmacytoma cell-free system resulted in a complete suppression of the translation of the cellular message, whereas viral RNA was translated normally.


Endemic goitre and thyroid function in Central Africa.


Endocrine functions during adaptation to stress.


Encephalomyocarditis virus infection of mouse plasmacytoma cells. II. Effect on host RNA synthesis and RNA polymerases. The effect of encephalomyocarditis virus infection of MOPC 460 mouse plasmacytoma cells on host RNA synthesis and RNA polymerases was investigated. Consistent with work performed in other virus host systems, rates of RNA synthesis appeared to be inhibited in infected cells, whereas RNA degradation appeared normal. These results were further extended with isolated nuclei, in which distinct RNA polymerase activities could be studied under conditions where problems with RNA turnover and endogenous nucleotide pool sizes were insignificant. Endogenous nuclear RNA polymerase II activity was inhibited early postinfection and at 1 to 2 h prior to endogenous RNA polymerase I plus III activity. However, the solubilized enzymes were fully active with exogenous DNA as template. In fact, the levels of RNA polymerases I, II, and III, isolated from infected cells and nuclei, were indistinguishable from levels in uninfected cells and nuclei at each stage of their partial purification procedure. The chromatographic properties of the enzymes on DEAE-Sephadex were also unaltered. Furthermore, the RNA synthetic activity of these isolated enyzmes, or of nuclei isolated from uninfected cells, was resistant to extracts of nuclei or of cytoplasmic fractions from infected cells. These results are discussed in terms of a possible inhibition of RNA synthesis in vivo at the level of transcription initiation.


Enhanced interferon response to murine leukemia virus by ascorbic acid. BALB/cJ mice, on an ad libitum regimen of 250 mg% l-ascorbate in their drinking water, displayed augmented levels of circulating interferon after stimulation with murine leukemia virus.


Enhancement of radiation effects by heating of the tumor.


Enhancement of radiation effects by chemotherapy.


Enhancement of DNA synthesis of mouse myelogenous cells by cyclic adenosine 3',5'-monophosphate (cAMP).


Enterovirus type 70: the etiologic agent of pandemic acute haemorrhagic conjunctivitis. A new enterovirus, now classified as enterovirus type 70, was isolated from the conjunctiva of patients with acute haemorrhagic conjunctivitis during the 1971 epidemics that occurred in Japan, Singapore, and Morocco. These epidemics were parts of a pandemic involving Africa (Algeria, Ghana, Morocco, Nigeria, and Tunisia), Asia (Cambodia, China (Province of Taiwan), Hong Kong, India, Indonesia, Japan, Malaysia, the Philippines, Singapore, and Thailand), and England during 1969-71. A representative strain from each of the three epidemic areas was studied cooperatively. The strains exhibited the physicochemical characteristics of enteroviruses. Cross-neutralization tests showed that these viruses were distinct from all known human enterovirus immunotypes, but that they were antigenically closely related. The human origin of the viruses was demonstrated by the appearance of homologous neutralizing antibodies during convalescence in patients with acute haemorrhagic conjunctivitis.


Environmental mutagen testing in Escherichia coli and phage lambda.


Enzymatic acylation of 1-alkyl-, 1-alkenyl- and 1-acyl glycero-3-phosphorylethanolamine in developing rat brain.


Enzymatic formation of uridine diphosphate N-acetyl-D-mannosaminuronic acid.


Endocrine tumors of the pancreas associated with elevated urinary serotonin excretion.


Enzymatic methods for sequence analysis applied to DNA restriction and methylation sites.


Epinephrine binding by rat liver plasma membranes: effect of guanyl nucleotides.


Epidermal growth factor: effects of androgens and adrenergic agents.


Epstein-Barr virus and heterophile antibodies in infectious mononucleosis.


Epstein-Barr virus specific diagnostic tests in infectious mononucleosis.


Equilibrium kinetic study of bovine liver glutamate dehydrogenase at high pH.


Erythrocyte membrane vacuole formation in hereditary spherocytosis.


Escape of intestinal resistance vessels to angiotensin II.


Estradiol receptors: a new evaluation.

Estradiol receptors: a new evaluation.


Escape of TA3 tumors from allogeneic immune rejection: theory and experiments.


Establishment of a tetraploid, immunoglobulin-producing cell line from the hybridization of two human lymphocyte lines. We here report the establishment of a seemingly permanent hybrid cell line formed by fusion of the cells of two biochemically mutant human lymphocyte lines. One parental line (UM-1-6TGr) was deficient in hypoxanthine-guanine phosphoribosyl transferase (IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8), and had two marker chromosomes. The second parental line (UM-21-5) was a clonal derivative of a citrullinemic lymphocyte line, and was, like the line of origin, dificient in argininosuccinic acid synthetase [(L)-Citrulline: (L)-aspartate ligase (AMP-forming), EC 6.3.4.5]. This line also had a marker chromosome, which was a B5 with a very prominent secondary constriction. After trypsinization of both parental lines, followed by addition to the fusion mixture of beta-propiolactone-inactivated Sendai virus, the cells were placed in a doubly selective medium (hypoxanthine-aminopterin-thymidine-containing medium in which the arginine was replaced with citrulline) to prevent the proliferation of the mutant parents. Under selective conditions, 97-99% of cells were found to be tetraploid, containing the three marker chromosomes; and the specific activities of the hybrid line transferase and synthetase were intermediate between normal and mutant line values. Furthermore, the UM-1-6TGr and UM-21-5 lines were producers of gamma and mu heavy chains of immunoglobulin, and of kappa light chains, as determined by immunodiffusion and immunofluorescence, and the hybrid line continued to synthesize and to secrete detectable levels of these same immunoglobulins. These studies demonstrate the genic and cytogenetic stability of this hybridized lymphocyte cell line, and prove that hybridization per se does not extinguish the activity of either the regulatory of structural genes involved in immunoglobulin synthesis.


Estrogen binding in the rat and human.

Estrogen binding in the rat and human.


Estrogen receptor transformation and nuclear RNA synthesis.


Estrogenic profile on a water-soluble estrogen, estrazinol hydrobromide. The estrogenic properties of estrazinol hydrobromide (EZ), a water-soluble estrogen, were compared with those of Premarin (PR), another water-soluble estrogen preparation consisting of conjugated equine estrogens.  Estradiol-17beta, estra-1,3,5(10)-triene-3,17beta-diol (E), and ethinyl estradiol, 17alpha-ethinyl-1,3,5 (10)-estratriene-3,17beta-diol (EE) were used as reference standards.  Subcutaneous progesterone (400 mcg) given to rabbits primed with comparable subcutaneous doses of either E or EE produced full secretory changes of the endometrium, while such a transformation could not be elicited in orally primed animals  regardless of the estrogen used.  The biological profile or orally administered EZ was very similar to that of oral EE and different from oral PR.  Howerver, the oral EZ-induced morphological changes of the rabbit endometrium appeared somewhat different from those produced by oral EE.  The findings indicated that following oral administration, EZ-induced endometrial transformation is more "normal" and/or adequate than the changes produced by either EE or PR.


Ethanol-induced inhibition of human intestinal enzyme activities: reversal by folic acid.


Evaluation of physical maturity in adolescent mentally retarded boys.


Evidence against formation of a pyrophosphoryl enzyme intermediate in the phosphoribosylpyrophosphate synthetase reaction.


Evidence for a role for protein phosphorylation in synaptic function in the cerebral cortex mediated through a beta noradrenergic receptor.


Evidence for a guanosine-3':5'-monophosphate-binding protein from rat cerebellum.


Evidence for a role of the Epstein-Barr virus in the etiology of human lymphoma.


Evidence for cooperative binding of Triton X-100 to bovine serum albumin.


Evolutionary clock: the rate of evolution of rattlesnake cytochrome c.


Existence of two pools of prostaglandins during stimulation of the thyroid by TSH.


Experimental autoallergic parotitis.

Experimental autoallergic parotitis.


Experimental transmission of equine adenovirus in Arabian and non-Arabian foals.


Facial muscle tonus during REM and NREM sleep.


Extraction, partial purification and characterization of 'the insoluble estrogen receptor' from chick liver nuclei.


EM49: a new polypeptide antibiotic active against cell membranes.


Factors affecting the saturation assay of cyclic AMP in biological systems.


Factors associated with treatment success in lithium carbonate prophylaxis. Report of the Veterans Administration and National Institute of Mental Health collaborative study group.


Facilitation by adenosine of the action of insulin on the accumulation of adenosine 3':5'-monophosphate, lipolysis, and glucose oxidation in isolated fat cells.


Failure of pentagastrin to stimulate cyclic AMP accumulation in human gastric mucosa.


False negative and prozone reactions in tests for antibodies to Epstein-Barr virus-associated nuclear antigen.


Familial homozygous hypobetalipoproteinemia.


Fatal adenovirus pneumonia in a young adult associated with ADV-7 vaccine administered 15 days earlier.


Fatty acid composition of the major lipid classes of very low density lipoproteins and of plasma in rats poisoned with carbon tetrachloride.


Feed preferences of adult male Dutch rabbits.


Fc binding of IgG to skeletal muscle tissue.


Feeding in ciliated protozoa. I. Pharyngeal disks in Euplotes: a source of membrane for food vacuole formation?


Fibrinolysis associated with oncogenic transformation. Morphological correlates.


Fibrinolysis associated with oncogenic transformation. Partial purification and characterization of the cell factor, a plasminogen activator.


Field nutrition survey of Nigerian children in Ivory Coast refugee camps.


Filtered air-positive pressure rearing of broiler chickens.


Flagyl and reduced nicotinamide adenine dinucleotide.


First night effect revisited: a clinical note.


Fluorescence studies of cytochrome c1 and a cytochrome c1-cytochrome c complex.


Function and interaction of on and off transients in vision. II. Neurophysiology.


Functional organization of the vestibular input to ocular motoneurons of the frog.


Further analysis of the resistance of a colony of rats to dextran.


Functional similarity of yeast and mammalian adenosine 3',5'-monophosphate-dependent protein kinases.


Further evidence for the heterogeneity of liver lysosomes.


Further studies on rat mast cell degranulation by IgE-anti-IgE and the inhibitory effect of drugs related to cAMP.


Gas gangrene in a greyhound.

Gas gangrene in a greyhound.


General anesthesia for surgery in the infant pigtail monkey, Macaca nemestrina.


Genetic blood markers and anthropometry of the populations in Aswan Governorate, Egypt.


Genetic counselling in retinoblastoma.

Genetic counselling in retinoblastoma.


Genital herpesvirus infection in pregnancy.


Glucose oxidation in alveolar macrophages: pharmacologic features.


Glycosyltransferases in canine respiratory tissue. Alterations in an experimentally induced hypersecretory state.


Golgi function and cell wall formation in the Conjugales.


Glycerol metabolism in Bacillus subtilis: gene-enzyme relationships. Bacillus subtilis mutants unable to catabolize glycerol (Glp mutants) were isolated and mapped. The location of the mutations on the chromosome was determined by a density transfer technique and confirmed by PBS1 transduction and transformation. The different mutations were ordered relative to each other. Mutations rendering the cells glycerol auxotrophic were also mapped and found not to be linked to the Glp mutations.


Geriatrics. Intermediate care facilities standards.


Gonadotropin receptors in rat ovarian tissue. I. Localization of LH binding sites by fractionation of subcellular organelles.


Goniotomy in congenital glaucoma.

Goniotomy in congenital glaucoma.


Gonadal hormones and triglycerides.

Gonadal hormones and triglycerides.


Gonadotropin receptors in rat ovarian tissue. II. Subcellular localization of LH binding sites by electron microscopic radioautography.


Granular cell tumor (myoblastoma) of the bladder.


Granular cell myoblastoma of the head and neck.


Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivo.


Granular cell myoblastoma located in the floor of the mouth.


Guinea pig insulin. II. Biological activity.


Growth of mouse hepatitis and other indigenous mouse viruses in tracheal organ cultures.


Hapten-specific tolerance in mice. II. Adoptive transfer studies and evidence for unresponsiveness in the B cells.


Health care cooperation at Aquarius Festival.


Haem ligands of the ferricytochrome c of Ustilago sphaerogena. The mammalian-type cytochrome c of the basidiomycete Ustilago sphaerogena contains in a single polypeptide chain of 107 residues, two histidine residues located at positions 18 and 33, and one methionine residue situated at position 80 (Bitar et al., 1972). The reaction of Ustilago ferricytochrome c with bromoacetate at neutral pH resulted in the modification of histidine-33, but not of histidine-18 or of the invariant methionine residue. The activities of Ustilago cytochrome c with mitochondrial cytochrome c oxidase and with NADH-cytochrome c reductase were unaltered by the modification. The equilibrium constants for the formation of low-spin complexes of the ferrihaem octapeptide of horse cytochrome c (residues 14-21, including the haem bound covalently to cysteines 14 and 17) with imidazole, N(2)-acetylhistidine and monocarboxymethyl derivatives of N(2)-acetylhistidine were determined spectrophotometrically. Alkylation of the imidazole side-chain group of N(2)-acetylhistidine resulted in a marked decrease in its ability to form low-spin ferrihaem complexes. These results indicate that in Ustilago ferricytochrome c in solution histidine-33 is not involved in the central co-ordination complex. Since side-chain groups of residues other than histidine and methionine do not appear to be involved in the central complexes of other mammalian-type cytochromes c (Hettinger & Harbury, 1964, 1965; Myer & Harbury, 1965) it is likely that in Ustilago ferricytochrome c in solution at neutral pH, the side-chain groups of histidine-18 and methionine-80 are involved in the central co-ordination complex. The latter is stable over the pH range 2.6-8.4.


Heat denaturation of D-glyceraldehyde-3-phosphate dehydrogenase holoenzyme.


Helix-coil transition and conformational studies of nucleoprotein: poly(L-arginine)- and poly(L-arginine87, L-ornithine13)-DNA complexes. II. Circular dichroism.


Hematological and serological effects of Rauscher leukemia virus and Epstein-Barr virus on immunosuppressed newborn subhuman primates.


Hepatic microsomal membrane: activation of glucose-6-phosphatase.


Heme proteins: hemoglobin.

Heme proteins: hemoglobin.


Herpes nodules in the lung of the African elephant (Loxodonta africana (Blumebach, 1792)).


High reactivity of kidney preparations from man, pig, beef, dog and rat for carbamyl phosphate hydrolysis.


Herring bodies reexamined: an ultrastructural experimental investigation of the rat neural lobe.


Herpesviruses and cancer.

Herpesviruses and cancer.


Histidine residues and the enzyme activity of pig heart supernatant malate dehydrogenase. 1. Supernatant pig heart malate dehydrogenase is completely inhibited by reaction with diethyl pyrocarbonate at pH6.5, when 0.58+/-0.1 residue of ethoxycarbonylhistidine is formed per NADH-binding site. 2. Oxaloacetate and hydroxymalonate protect the enzyme from inhibition in the absence of coenzyme. 3. Limited ethoxycarbonylation does not alter the binding of NADH to the enzyme but prevents the enzyme-NADH complex from interacting with hydroxymalonate in a ternary complex.


Histochemical findings on sodium-potassium activated adenosine triphosphatase (NaK-ATPase) activity in the cornea.


Histochemical studies of hepatic enzymes in dogs subjected to lobar bile duct obstruction.


Histologic and histochemical studies on C cells in the thyroid gland in white rats under conditions of chronic hypercalcemia induced with vitamin D3.


Histochemistry and ultrastructure of atypical myoclonus body (type II).


Hormonal effects on mammary cytology.

Hormonal effects on mammary cytology.


Hormonal control of lipolysis.

Hormonal control of lipolysis.


Human ecthyma contagiosum (orf) in the Faroe islands. An epidemiological and electron microscopical study.


Human N-acetyl-beta-hexosaminidases: hydrolysis of N, N' diacetylchitobiose by a low molecular weight enzyme.


Hormone-receptor interactions with the genome of eucaryotic target cells.


Hypoglycemia in infancy caused by beta cell nesidioblastosis.


Identification of bile acids as their derivatives by 100 MHZ PMR spectroscopy.


Iatrogenic disorders in epilepsy.

Iatrogenic disorders in epilepsy.


Hepatoma associated with ulcerative colitis: Report of a case.


Identification of missense mutants by amino acid replacements in iso-1-cytochrome c from yeast.


Identity of a newly isolated human polyomavirus from a patient with progressive multifocal leucoencephalopathy. Isolation of a strain of polyomavirus, designated COL, from the brain of a patient with progressive multifocal leucoencephalopathy is described. The COL strain is antigenically similar to JC polyomavirus, previously isolated from a brain affected by progressive multifocal leucoencephalopathy and is unrelated to BK, another human polyomavirus isolated from urine. Immunological cross testing of viruses in the Polyomavirus genus shows that there are at least six antigenic types in this group.


Immunity in viral and rickettsial diseases. Round table conference.


Immunocytes and leukemia virus infection: effects on bone marrow and thymus cell responses and interactions.


Immunodeficiency states.

Immunodeficiency states.


Immunologic study of an oncornavirus isolated from a human cancer cell line.


Immunofluorescence and elution studies in tetraparental NZB forms and is formed from CFW chimaeras and graft-versus-host diseased NZB.


Immunological studies of the protein moieties of human plasma very low-density and low-density lipoproteins.


Immunological cross-reactions between two low-molecular-weight polypeptides from a murine type C virus. Two low-molecular-weight type-specific virion polypeptides from the Kirsten strain of Murine leukemia virus, polypeptides p10 and p12, are immunologically related by radioimmunoassay competition techniques.


Implications of selection for high and low adrenal response to stress.


Immunospecificity of chromatin nonhistone protein--DNA complexes in normal and neoplastic growth.


Important events in photosynthesis.

Important events in photosynthesis.


Improved prognosis of infants mechanically ventilated for hyaline membrane disease.


In vitro labelling of childhood cancers with tritiated thymidine.


In vitro synthesis of structural proteins of Semliki Forest virus directed by isolated 26 S RNA from infected cells.


In vitro synthesis of proteins by membrane-bound polyribosomes from vesicular stomatitis virus-infected HeLa cells. Membrane-bound polysomes from vesicular stomatitis virus (VSV)-infected HeLa cells synthesize predominantly three proteins in an in vitro protein synthesizing system. These three proteins have different molecular weights than the viral structural proteins, i.e., 115,000, 88,000, and 72,000. Addition of preincubated L or HeLa cell S10 or HeLa cell crude initiation factors stimulates amino acid incorporation and, furthermore, alters the pattern of proteins synthesized. Stimulated membrane-bound polysomes synthesize predominantly viral protein G and lesser amounts of N, NS, and M. In vitro synthesized proteins G and N are very similar to virion proteins G and N based on analysis of tryptic methionine-labeled peptides. Most methionine-labeled tryptic peptides of virion G protein contain no carbohydrate moieties, since about 90% of sugar-labeled peptides co-chromatograph with only about 10% of methionine-labeled peptides. Sucrose gradient analysis of the labeled RNA present in VSV-infected membrane-bound polysomes reveals a relative enrichment in a class of viral RNA sedimenting slightly faster than the total population of the 13 to 15S mRNA, as compared to a VSV-infected crude cytoplasmic extract. A number of proteins, other than the viral structural proteins, are synthesized in the cytoplasm of five lines of VSV-infected cells. One of these proteins has the same molecular weight as the major in vitro synthesized protein, P(88). In vitro synthesized protein P(88) does not appear to be a precursor of viral structural proteins G, N, or M based on pulse-chase experiments and tryptic peptide mapping. Nonstimulated membrane-bound polysomes from uninfected HeLa cells synthesize the same size distribution of proteins as nonstimulated VSV-infected membrane-bound polysomes.


In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase. Synthesis of Rous sarcoma virus RNA was examined in vitro with a new assay for radioactive virus-specific RNA. Nuclei from infected and uninfected cells were incubated with ribonucleoside [alpha-(32)P]triphosphates, Mn(++), Mg(++) and (NH(4))(2)SO(4). Incorporation into total and viral RNA proceeded with similar kinetics for up to 25 min at 37 degrees . About 0.5% of the RNA synthesized by the infected system was scored as virus-specific, compared to 0.03% of the RNA from the uninfected system and 0.005% of the RNA synthesized by monkey kidney cell nuclei. Preincubation with DNase or actinomycin D completely suppressed total and virus-specific RNA synthesis. alpha-Amanitin, a specific inhibitor of eukaryotic RNA polymerase II, completely inhibited virus-specific RNA synthesis, while reducing total RNA synthesis by only 50%. We conclude that tumor virus-specific RNA is synthesized on a DNA template, most probably by the host's RNA polymerase II.


In vivo and in vitro properties of a temperature sensitive mutant of infectious bovine Rhinotracheitis virus.


Inactivation of trypsinogen by methane sulfonyl fluoride.


In vivo effects of pancreozymin, secretin, vasoactive intestinal polypeptide and pilocarpine on the levels of cyclic AMP and cyclic GMP in the rat pancreas.


Incidence of clostridia in meat products.


Incidence of postoperative complications in patients subjected to surgery under steroid cover.


Increase in hepatic NAD level--its effect on the redox state and on ethanol and acetaldehyde metabolism.


Increase of serum free thyroxine following the administration of thiocyanate and other anions in vivo and in vitro.


Increased binding of calcitonin to renal receptors in parathyroidectomized rats.


Increased paradoxical sleep in mice during acquisition of a shock avoidance task.


Increased PRPP synthetase activity in rapidly growing hepatomas.


Increased thermal stability of chromatin containing 5-bromodeoxyuridine-substituted DNA. The replacement of thymidine by 5-bromodeoxyuridine in DNA leads to a greatly enhanced stability of chromatin from hepatoma tissue culture or embryonic rat pancreas, as measured by thermal chromatography on hydroxylapatite. The increased stability is directly correlated with the degree of bromodeoxyuridine substitution. On the other hand, the incorporation of bromodeoxyuridine into DNA results in a modest stabilization of purified DNA. Substitution of nucleotide also alters slightly the hyperchromicity profile generated during the thermal denaturation of purified DNA and chromatin. The observed changes can best be explained by an altered interaction between the bromodeoxyuridine-DNA and other chromatin components, presumably proteins. These results suggests that the selective effects of bromodeoxyuridine on cytodifferentiation may be due to an increased affinity of regulatory proteins for bromodeoxyuridine-DNA.


Increases in activities of aminoacyl-tRNA synthetases during cold-treatment of dormant pear embryo.


Induction and inhibition of ovulation in the rat by intracerebral progesterone implants.


Infectious tenosynovitis: serologic and histopathologic response after experimental infection with a Connecticut isolate.


Inflammatory pseudotumor of the lung.

Inflammatory pseudotumor of the lung.


Influence of ligands on the coenzyme dissociation constants in octopine dehydrogenase.


Influence of NAD+ on development of mouse blastocysts in vitro.


Inhibition by interferon of SV40 tumor antigen formation in cells injected with SV40 cRNA transcribed in vitro.


Inhibition effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat.


Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B. Role of subplasmalemmal microfilaments. Functional and morphologic effects of cytochalasin B on the cultivated macrophage were examined to determine the basis for plasma membrane movements of the type required for endocytosis and/or spreading on a substratum. Inhibition of phagocytosis and changes in cell shape by cytochalasin B exhibited nearly identical dose-response curves requiring 2-5 x 10(-6) M and 1-2 x 10(-5) M cytochalasin B to inhibit these functions by 50% and 100%, respectively. In contrast, hexose transport was ten times more sensitive to the drug requiring 2-3 x 10(-7) M cytochalasin B to achieve 50% inhibition of 2-deoxyglucose uptake. Inhibition of phagocytosis and changes in cell shape could not be explained solely by drug effects on hexose transport. Analysis of serial thin sections showed that cytochalasin B doses inhibitory for hexose transport had no effect on distribution or organization of either of the two subplasmalemmal microfilament types. However, cytochalasin B concentrations (2.0 x 10(-5) M) that inhibited phagocytosis and altered cell shape disorganized and/or disrupted oriented bundles of 40-50-A subplasmalemmal microfilaments, but had no effect on the microfilamentous network. Comparative dose-response studies showing positive correlations among cytochalasin B effects on phagocytosis, changes in cell shape, and alterations in oriented subplasmalemmal microfilament bundles provide additional support for the hypothesis that microfilamentous structures play a role in translocation of plasma membrane required for endocytosis and cell motility.


Inhibition of a vesicular stomatitis virus mutant by rifampin. Rifampin reversibly inhibits the intracellular replication of a VSV mutant, whereas a revertant variant selected from this viral population, as well as the wild strain, are not affected by this drug. Rifampin inhibits transcriptase activity of the sensitive mutant only and, consequently, total viral RNA synthesis decreases significantly in the cells.


Inhibition of rat liver Ca2+, Mg2+-dependent endonuclease activity by nicotinamide adenine dinucleotide and poly (adenosine diphosphate ribose) synthetase.


Inhibition of AMV DNA polymerase by polyriboadenylic acid containing epsilon-adenosine residues.


Inhibitory effects of central hypertensive activity of angiotensin I and II by 1-sar-8-ala-angiotensin II (saralasin acetate).


Inhibition of 3',5'-nucleotide phosphodiesterase in guinea pig cerebral cortical slices.


Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis.


Insulin secretion: multifactorial regulation for a single process of release. The Minkowski award lecture delivered on September 7, 1972 before the European Association for the study of Diabetes at Madrid, Spain.


Interactions of glucagon, gut glucagon, vasoactive intestinal polypeptide and secretin with liver and fat cell plasma membranes: binding to specific sites and stimulation of adenylate cyclase.


Interaction of human serum high density lipoproteins with triglycerides in vitro.


Interaction of phalloidin with actin.

Interaction of phalloidin with actin. Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in vitro poisoning. Both phalloidin induced filaments are resistant to 0.6 M KI in contrast to F-actin, and become decorated by heavy meromyosin. After preincubation with cytochalasin B significantly fewer actin filaments are observed.


Interactions of LH and hCG with testicular gonadotropin receptors.


Interconversion of ampicillin and hetacillin in vitro.


Intermembrane electron transfer in mitochondrial and microsomal systems.


Intermolecular steric interactions and lipid chain fluidity in phospholipid multibilayers. A spin label study.


Interstitial cell tumor of the testicle in rabbits: a report of two cases.


Intracranial causes of headache.

Intracranial causes of headache.


Intranuclear annulate lamellae in Ehrlich ascites tumour cells.


Intestinal glycoproteins of germfree rats. 3. Characterization of a water-soluble glycoprotein fraction.


Intranuclear concentration of lysosomal hydrolases in steroid target cells. Acute response to administration of gonadal hormones in vivo.


Introduction of mouse L cell nucleus into heterologous mammalian cells.


Investigation of a family with hypertrophic neuropathy resembling Roussy-Levy syndrome. Clinical, electrophysiologic, histologic, and biochemical studies.


Investigation of recognition sites in valine tRNA I (Baker's yeast) by dissected molecule method.


Investigations on the release of membrane-bound glyceraldehyde-3-phosphate dehydrogenase.


Is cortisol metabolized as it dissociates from glucocorticoid receptors in thymus cells?


Iontophoretic and autoradiographic studies on the role of proline in nervous transmission.


Isolation and identification of infectious bursal disease virus in Lebanon.


Isolation and characterization of plasma and smooth membranes of the marine diatom Nitzschia alba.


Isolated hypoaldosteronism associated with idiopathic hypoparathyroidism.


Isolation and partial characterization of a glycoprotein from bovine cortical bone.


Japanese encephalitis vaccination in Thailand.


Isolation of a myelogenous leukemia-inducing virus from mice infected with the Friend virus complex.


Juvenile fibroma of antral origin.

Juvenile fibroma of antral origin.


Juvenile GM1 gangliosidosis. Occurrence with absence of two beta-galactosidase components.


Kinetic techniques for the investigation of amino acid: tRNA ligases (aminoacyl-tRNA synthetases, amino acid activating enzymes).


Klebsiella air sacculitis in the owl monkey (Aotus trivirgatus).


Kinetics of aminoacyl-tRNA synthetases catalyzed ATP-PPi exchange.


Letter: Basal cell adenomas.

Letter: Basal cell adenomas.


Letter: Feline leukemia virus.

Letter: Feline leukemia virus.


Letter: On the possible role of cAMP in receptor dark adaptation.


Letter: Relief of pain in women with genital herpes.


Letter: Letter: Nucleotide distribution in bacterial DNA's differing in G plus C content.


Levels of adenosine 3',5'-cyclic monophosphate in the cerebral cortex of aging rats.


Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.


Laboratory aids in the diagnosis of tumors of the pancreas.


Lightly haptenated proteins induce IgM-deficient antibody responses.


Lipid acceptor in UDPglucuronic acid metabolism in rat liver microsomes.


Lipid phase transitions and drug interactions.


Lipids of potato tubers. 3. Effect of growth and storage on lipid content of the potato tuber.


Lipid composition and cholesterol esterification in lymph.


Lipotropic and adrenocorticotropic hormones. Biological activities of the carboxyl-modified hormones.


Lipoproteins and lipolytic plasma enzymes in a case of tangier disease.


Liver and spleen in rats after intravenous injection of Lipiodol Ultra-Fluide and 99Tcm-sulphide colloid.


Liver cirrhosis and hepatoma in rats induced by 3-benzylsydnone-4-acetamide.


Local immunity to avian infectious bronchitis in tracheal organ culture.


Long-term stimulatory effects of adenosine 3',5'-cyclic monophosphate on nuclear and cytoplasmic protein synthesis of rat hepatocytes in primary culture.


Long-term survival after massive liver resection for hepatocellular carcinoma.


Lumbar myelography and arachnoiditis.

Lumbar myelography and arachnoiditis.


Lymphocyte tubuloreticular structures in lupus erythematosus. Correlation with disease activity.


Luteinizing hormone receptors in luteinized rat ovaries.


Lymphotic inclusions in I-cell disease.

Lymphotic inclusions in I-cell disease.


LH does not increase cyclic AMP in the thyroid.


Lysosomal labilization: rapid, target-specific effect of ACTH.


Linitis plastica carcinoma of the intestine: Report of four cases.


Magnetic resonance studies on glutamate dehydrogenase.


LH-RH interaction with the pituitary plasma membrane is affected by sex steroids.


Malignant chemodectoma of the superior mediastinum with elevated urinary homovanillic acid.


Malignant melanoma in a snake.

Malignant melanoma in a snake.


Mass fragmentographic determination of eleven estrogens in the body fluids of pregnant and nonpregnant subjects. Mass fragmentographic determinations of 11 estrogens in urine, bile, or plasma of pregnant and nonpregnant subjects were made.  The estrogens (estriol, estrone, 2-methoxyestrone, estradiol-17beta, estradiol-17alpha, 16-epiestriol, 17-epiestriol, 16-alpha-hydroxyestrone, 16beta-hydroxyestrone, 16oxoestradiol-17beta, and 15alpha-hydroxyestrone) were quantitatively  determined in bile from 1 male and 3 postmenopausal women, in the urine of a nonpregnant woman, and in a 20 ml pool of late pregnancy plasma obtained from 10 women.  The specificity of mass fragmentography as compared with gas chromatography is considered better because a characteristic ion is monitored rather than the total ion current measured by flame ionization detection and reliable measurements can  be made in the presence of larger amounts of impurities, resulting in a shortened fractionation procedure.


Mass spectra of trimethylsilyl ethers of 2H-labelled mono- and diglycerides.


Mathematics of hormone-receptor interaction. I. Basic principles.


Measurement of the second and fourth components of rat complement.


Major or minor tranquilizers for relief of common symptoms of psychoneurosis?


Measurement of the sequence complexity of cloned Moloney murine leukemia virus 60 to 70S RNA: evidence for a haploid genome. The sequence complexity of the 60-70S RNA complex from Moloney murine leukemia virus (M-MuLV) was determined by measuring the annealing rate of radioactively labeled virus-specific DNA with M-MuLV 60-70S RNA in conditions of vast RNA excess. The M-MuLV RNA annealing rate, characterized by the quantity C(r)t((1/2)), was compared with the C(r)t((1/2)) values for annealing of poliovirus 35S RNA (2.6 x 10(6) molecular weight) with poliovirus-specific DNA and Sindbis virus 42S RNA (4.3 x 10(6) molecular weight) with Sindbis-specific DNA. M-MuLV-specific DNA was prepared in vitro by the endogenous DNA polymerase reaction of M-MuLV virions, and poliovirus and Sindbis virus DNAs were prepared by incubation of viral RNA and DNA polymerase purified from avian myeloblastosis virus and an oligo deoxynucleotide primer. The poliovirus and Sindbis virus DNAs were sedimented through alkaline sucrose gradients, and those portions of the DNA with sizes similar to the M-MuLV DNA were selected out for the annealing measurements. M-MuLV was cloned on NIH-3T3 cells because it appeared possible that the standard source of M-MuLV for these experiments was a mixture of viruses. The annealing measurements indicated a sequence complexity of approximately 9 x 10(6) daltons for the cloned M-MuLV 60-70S RNA when standardized to poliovirus and Sindbis virus RNAs. This value supports the hypothesis that each of the 35S RNA subunits of M-MuLV 60-70S RNA has a different base sequence.


Mechanism of cell contact-dependent glycolipid synthesis: further studies with glycolipid-glass complex.


Mechanism of bacitracin action: a specific lipid-peptide interaction.


Maternal cardiovascular adjustments to pregnancy.


Mechanism of control of skeletal-muscle contraction by dantrolene sodium.


Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside.


Mechanism of the interferon-induced block of mRNA translation in mouse L cells: reversal of the block by transfer RNA.


Mechanisms of spasticity.

Mechanisms of spasticity.


Meiotic maturation of the mammalian oocyte in vitro: effect of dibutyryl cyclic AMP on protein synthesis.


Membrane filtration in the study of antimicrobial drugs. A membrane filtration apparatus of the type employed in water bacteriology was used in the assessment of some antimicrobial drugs. Samples of liquid nutrient medium inoculated with a small number of bacteria, to which dilutions of a drug had been added before incubation and again later, were filtered and the membranes washed and incubated on solid medium. By this means differences between bacteriostatic and bactericidal action were clearly demonstrated. It was shown that staphylococci which had survived exposure to penicillin or gentamicin at levels below their minimum bactericidal concentrations remained fully responsive to the subsequent addition of more of the same drug, while those which had survived exposure to chloramphenicol or clindamycin were not significantly affected by further addition, so that neither of the latter two drugs was bactericidal against the strain of organism used. Bactericidal effects were also demonstrated by benzyl penicillin against Clostridium welchii and ampicillin against Escherichia coli.


Membrane orientation in vesicles from Micrococcus lysodeikticus cells.


Membrane receptors.

Membrane receptors.


Metabolic effects of 2-phenylethanol, 1,1-dimethylphenylethanol, periodate and succinic anhydride on intact yeast cells and on fermenting preparations from lyophilized yeast.


Metabolism of progesterone in the chick oviduct: relation to the progesterone receptor and biological activity.


Metabolic effects of N6-substituted adenosines in rats.


Metabolites and the incorporation of L-leucine into rabbit insulin in vitro.


Methaqualone: an irrational hypnotic.

Methaqualone: an irrational hypnotic.


Methodological problems and clinical validity of an ACTH radioimmunoassay method applied to extracted plasma samples.


Methoxyflurane anesthesia for Rana pipiens.


Methylglyoxal formation during glucose catabolism by Pseudomonas saccharophila. Identification of methylglyoxal synthase.


Micro hemagglutination-inhibition test for detection of CELO virus antibodies.


Microcirculation and hypoxia.

Microcirculation and hypoxia.


Mineral metabolism and skeletal development of lambs affected by Trichostrongylus colubriformis.


Minimal change and focal sclerotic lesions in lipoid nephrosis.


Melatonin: cellular effects on live stentors correlated with the inhibition of colchicine-binding to microtubule protein.


Mobility of protein molecules in Micrococcus lysodeikticus membranes.


Mitochondrial heterosis.

Mitochondrial heterosis.


Modification of cysteine residues with sodium 2-bromoethanesulfonate. The application of S-sulfoethylated peptides in automatic Edman degradation.


Modifications in the purified rabbit skeletal muscle apophosphorylase-b assay of serum pyridoxal phosphate levels.


Modifications in the chromosomal proteins of SV-40 transformed WI-38 human diploid fibroblasts.


Modified radioimmunoassay for murine sarcoma-leukemia virus group-specific antigen. Iodination of disrupted Moloney strain murine sarcoma-leukemia virus resulted in labeled group-specific (gs) protein which was subsequently purified on an isoelectrofocusing column. This iodinated purified gs antigen, prepared from a relatively small quantity of purified virus, was used in a radioimmunoassay. A radioimmunoassay inhibition method was developed so that antibody specific for mammalian C-type gs antigen could be measured in undiluted or low dilutions of test serum without altering the known reagents of the test. The gs antigen isolated from purified Moloney strain murine sarcoma-leukemia virus has an isoelectric point (pH 5.95) which is significantly lower than that reported for other murine leukemia viruses.


Modulation of the baroreceptor reflex by central administration of angiotensin.


Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats.


Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats.


Molecular orbital studies of the conformation around the 5 position in angiotensin II.


Molecular orbital study on the interaction between coenzymes and enzymes; NAD+ or NADH and dehydrogenases.


Morphological basis of diffusion through the iris vessels in the dynamics of the aqueous humour.


Molecular weight of microsomal glucose-6-phosphatase of rat and human liver.


Motor end-plate fine structure in acrylamide dying-back neuropathy: a sequential morphometric study.


Morphological observations on visceral leishmaniasis in the Sudan.


Mulibrey nanism; an inherited dysmorphic syndrome with characteristic ocular findings.


Multicentric chemodectomata at high altitude. A case report and review of the literature.


Motor unit recruitment as reflected by muscle fibre glycogen loss in a prosimian (bushbaby) after running and jumping. A qualitative histochemical assessment of glycogen loss in biopsies was made in bush-babies after running and jumping. Glycogen loss was related to the specific type of exercise. After running, glycogen loss was greatest in the slow-twitch oxidative fibre and depletion in the fast-twitch oxidative glycolytic fibres was similarly greater than in the fast-twitch glycolytic fibres. After jumping, the opposite pattern of glycogen utilization occurred (FG>FOG>SO).


Multiple aggregation states of phosphoribosyladenosine triphosphate synthetase.


Multiple forms of solubilized gonadotropin receptors from the rat testis.


Murine cytomegalovirus-infected liver: depletion of acid phosphatase with concomitant increase of alkaline phosphate.


Multiple primary carcinomas of respiratory tract: primary carcinoma of larynx followed by primary carcinomas involving two lungs consecutively.


Muscle length and neuromuscular transmission in the frog.


Mutagens in the biosphere.

Mutagens in the biosphere.


Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells.


Mutant of Salmonella typhimurium that channels infecting bacteriophage P22 toward lysogenization. A slowly growing, polymyxin-sensitive mutant of Salmonella typhimurium was isolated. Wild-type phage P22 form plaques on the mutant at 5 x 10(-4), the frequency observed on wild-type hosts. All P22 clear mutants form plaques with near normal frequency. The inability of the mutant to form plaques is correlated with an increase in lysogenization frequency. The cause of the increased lysogenization frequency is not known, but it is not the result of overproduction of cyclic adenosine 5'-monophosphate.


Myelin enzymes and protein metabolism.

Myelin enzymes and protein metabolism.


Mössbauer studies of some complexes of the undecapeptide of cytochrome c.


Neo-natal mortality of puppies in Queensland caused by canine herpesvirus infection.


Needle biopsies in pulmonary diagnostics.


Neonatal hematuria.

Neonatal hematuria.


Myocardial function and lipid metabolism in the chronic alcoholic animal. In view of the variables that obscure the pathogenesis of cardiomyopathy, a study was undertaken in mongrel dogs fed ethanol as 36% of calories for up to 22 mo. Both the experimental and control groups maintained body weight, hematocrit, plasma vitamin, and protein levels. Left ventricular function was evaluated in the intact anesthetized dog using indicator dilution for end-diastolic and stroke volume determinations. During increased afterload with angiotensin, the ethanol group exhibited a larger rise of end-diastolic pressure (P<0.01), whereas end-diastolic and stroke volume responses were significantly less than in controls. Preload increments with saline elicited a significantly higher end-diastolic pressure rise in the ethanol group (P<0.01). No hypertrophy, inflammation, or fibrosis was present and it was postulated that the enhanced diastolic stiffness was related to accumulation of Alcian Blue-positive material in the ventricular interstitium. To evaluate myocardial lipid metabolism, [1-(14)C]oleic acid was infused systemically. Plasma specific activity and myocardial lipid uptake were similar in both groups. There was a significantly increased incorporation of label into triglyceride, associated with a reduced (14)CO(2) production, considered the basis for a twofold increment of triglyceride content. In addition, diminished incorporation of [(14)C]oleic acid into phospholipid was observed accompanied by morphologic abnormalities of cardiac cell membranes. Potassium loss and sodium gain, like the lipid alteration, was more prominent in the subendocardium. Thus, chronic ethanol ingestion in this animal model is associated with abnormalities of ventricular function without evident malnutrition, analogous to the preclinical malfunction described in the human alcoholic.


Neural-tube defects and herpesvirus type 2--test of a hypothesis.


Neurilemmoma of the choroid in Recklinghausen's disease.


Neutralizing antibodies to herpesvirus types 1 and 2 in carcinoma of the cervix, carcinoma in situ and cervical dysplasia.


Neurophysiologic mechanisms of hemiplegic and paraplegic spasticity: implications for therapy.


Neutralizing antibodies to herpesvirus types 1 and 2 in Montreal women.


New experimental approaches.

New experimental approaches.


N-oxide formation and related reactions in drug metabolism.


No evidence for a carbohydrate moiety affecting the clearance of circulating human leukocyte interferon in rabbits.


Non-metastatic neurological minifestations of malignant disease.


Non-polio virus interference with oral polio vaccine immunization: possible influence of physical climate and socio-economic status.


Non-transmitting neuromuscular junctions during an early stage of end-plate reinnervation. 1. Electrophysiological studies were made on regenerating motor end-plates in frog cutaneous pectoris muscle after crushing the motor nerve.2. The pattern of degenerative and regenerative changes is similar to that already described for the frog sartorius, although it occurs more quickly in the cutaneous pectoris. Resumption of synaptic transmission first occurs after 9 days, in muscle fibres closest to the nerve crush. During the subsequent 12 days synaptic contact is progressively re-established across the muscle.3. During the period of regeneration muscle fibres can be found which have been reinnervated, but which do not produce an end-plate potential in response to stimulation of the nerve trunk. This is referred to as the ;non-transmitting' stage of regeneration.4. Increases in extracellular potassium, addition of lanthanum to the bath and focal extracellular stimulation all indicate that the axon terminals at non-transmitting junctions do have a releasable supply of neurotransmitter. Focal stimulation occasionally sets up active responses in these nerve terminals.5. It is concluded that this ;non-transmitting' stage results from failure of action potential propagation in the regenerating neurone proximal to the end-plate region.


Nonfunctioning nonchromaffin paraganglioma of the pancreas.


Nuclear concentration of estriol in superfused human endometrium; competition with estradiol.


Novikoff hepatoma nuclear 8-18S RNA.

Novikoff hepatoma nuclear 8-18S RNA.


Nuclear receptor-estrogen complexes of rat uteri: concentration-time-response parameters.


Nucleotide pyrophosphatase, a sialoglycoprotein located on the hepatocyte surface.


Nucleotide sequence analysis of bacteriophage DNA.


Nuclear ribonucleoprotein complexes containing polyadenylate from mouse ascites cells. Nuclear poly(A)-containing RNA of mouse ascites cells can be extracted in the form of 15-17S ribonucleoprotein complexes under conditions in which the bulk of the heterogeneous nuclear RNA is released as 30S complexes. The poly(A)-containing fraction of nuclear extracts has been resolved into two distinct components, 15 and 17 S; neither contains the two polypeptides of 30S ribonucleoprotein. The 17S particle contains approximately six polypeptide species of molecular masses 17,000-30,000 daltons. The 15S complex has four distinct polypeptides of higher molecular mass, including a prominent 80,000-dalton species.


NADH brain surface scanning and 3-D computer display.


NADH, a physiological electron donor in clostridial nitrogen fixation.


NH2-terminal sequence of yeast inorganic pyrophosphatase.


N6-(delta2-isopentenyl)adenosine 5'-monophosphate: formation and effect on purine metabolism in cellular and enzymatic systems.


Observations on the structural arrangement of the somatic sensory innervation in the iris of mammals.


Occupational therapist in home health.

Occupational therapist in home health.


Observations on vibrio eltor.

Observations on vibrio eltor.


Observations on uptake of herpes simplex virus in organized cultures of mammalian nervous tissue.


On the development of a well-defined source of superoxide ion for studies with biological systems.


On the electron donor property of veratrine.


On the interaction of periodate oxidized GDP and its borohydride reduction product with the elongation factors Tu and G from Escherichia coli.


On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin action.


On the nature of the spin coupling between the iron-sulfur clusters in the eight-iron ferredoxins.


One-step separation of human plasma angiotensinogen from renin.


Oral infection of Culicoides variipennis with bluetongue virus: development of susceptible and resistant lines from a colony population.


Origin of asymmetry in biomolecules.

Origin of asymmetry in biomolecules.


Oxaziridines as possible intermediates in flavin monooxygenases. The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed "carbonyl oxide" and flavin peroxide models are discussed.


Oxygen poisoning in the unanesthetized brain: correlation of the oxidation-reduction state of pyridine nucleotide with electrical activity.


Paediatric ophthalmology in Northern Finland--a population investigation.


Pancreatic surgery in the 1960s.

Pancreatic surgery in the 1960s.


Parental compliance with postdischarge recommendations for retarded children.


Partial inhibition of hydroxyurea on liver tumors induced by N, N-dimethyl-4-aminoazobenzene.


Partial nephrectomy--a pathological evaluation.


Participation of mononuclear phagocytes in chronic inflammatory diseases.


Particles similar to mouse leukaemia virus in Ehrlich's ascites carcinoma and in reticulum cell noeplasms type B. An electron microscopic study in mice.


Patterns of spontaneous cortisol and growth hormone secretion in rhesus monkeys during the sleep-waking cycle.


Patterns of changes in brain carbohydrate metabolites, amino acids and organic phosphates at increased carbon dioxide tensions.


Pellicular immobilized enzymes.

Pellicular immobilized enzymes.


Oncolytic action of prostaglandins.

Oncolytic action of prostaglandins.


Pelvic arteriography in the diagnosis of malignant trophoblastic disease.


Peptide hormones.

Peptide hormones.


Peptide synthesis.

Peptide synthesis.


Persistence of complement-fixing antibodies in guinea pig sera serially collected in large volumes.


Persistence of late SV40 genome transcription after inhibition of DNA relication by cytosine arabinoside.


Persistent albuminuria and meningitis caused by congenital cytomegalovirus infection. A case report of cytomegalic inclusion disease.


Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles.


Phase specific surface autoantigens on membranes of fetus and tumors.