Subplasmalemmal microfilaments and microtubules in resting and phagocytizing cultivated macrophages. The subplasmalemmal organization of the free and glass-attached surfaces of resting and phagocytizing cultivated macrophages were examined in an attempt to define specific membrane-associated structures related to phagocytosis. From analysis of serial thin sections of oriented cells it was found that the subplasmalemmal region of the attached cell surface has a complex microfilament and microtubule organization relative to the subplasmalemmal area of the free surface. A filamentous network composed of 40-50-A microfilaments extended for a depth of 400-600 A from the attached plasma membrane. Immediately subjacent to the filamentous network was a zone of oriented bundles of 40-50-A microfilaments and a zone of microtubules. Additional microtubules were found to extend from the plasma membrane to the interior of the cell in close association with electron-dense, channellike structures. In contrast, the free aspect of the cultivated macrophage contained only the subplasmalemmal filamentous network. However, after a phagocytic pulse with polystyrene particles (14 microm diam) microtubules and oriented filaments similar to those found on the attached surface were observed surrounding the ingested particles. The observations reported in this paper provide support for the hypothesis that microfilaments and/or microtubules play a role in the translocation of plasma membrane required for the functionally similar processes of phagocytosis and cell attachment to glass.


The polymerization of actin: its role in the generation of the acrosomal process of certain echinoderm sperm. When Asterias or Thyone sperm come in contact with egg jelly, a long process which in Thyone measures up to 90 microm in length is formed from the acrosomal region. This process can be generated in less than 30 s. Within this process is a bundle of microfilaments. Water extracts prepared from acetone powders of Asterias sperm contain a protein which binds rabbit skeletal muscle myosin forming a complex whose viscosity is reduced by ATP. Within this extract is a protein with the same molecular weight as muscle actin. It can be purified either by collecting the pellet produced after the addition of Mg(++) or by reextracting an acetone powder of actomyosin prepared by the addition of highly purified muscle myosin to the extract. The sperm actin can be polymerized and by electron microscopy the polymer is indistinguishable from muscle F-actin. The sperm actin was shown to be localized in the microfilaments in the acrosomal processes by: (a) heavy meromyosin binding in situ, (b) sodium dodecyl sulfate (SDS) gel electrophoresis of the isolated acrosomal processes and a comparison to gels of flagella which contain no band corresponding to the molecular weight of actin, and (c) SDS gel electrophoresis of the extract from isolated acrosomal caps. Since the precursor for the microfilaments in the unreacted sperm appears amorphous, we suspected that the force for the generation of the acrosomal process is brought about by the polymerization of the sperm actin. This supposition was confirmed, for when unreacted sperm were lysed with the detergent Triton X-100 and the state of the actin in the sperm extract was analyzed by centrifugation, we determined that at least 80% of the actin in the unreacted sperm was in the monomeric state.


Microfilaments in the polar lobe constriction of fertilized eggs of Ilyanassa obsoleta.


Golgi fractions prepared from rat liver homogenates. I. Isolation procedure and morphological characterization. In devising a new procedure for the isolation of Golgi fractions from rat liver homogenates, we have taken advantage of the overloading with very low density lipoprotein (VLDL) particles that occurs in the Golgi elements of hepatocytes approximately 90 min after ethanol is administered (0.6 g/100 g body weight) by stomach tube to the animals. The VLDLs act as morphological markers as well as density modifiers of these elements. The starting preparation is a total microsomal fraction prepared from liver homogenized (1:5) in 0.25 M sucrose. This fraction is resuspended in 1.15 M sucrose and loaded at the bottom of a discontinuous sucrose density gradient. Centrifugation at approximately 13 x 10(6)g.min yields by flotation three Golgi fractions of density >1.041 and <1.173. The light and intermediate fractions consist essentially of VLDL-loaded Golgi vacuoles and cisternae. Nearly empty, often collapsed, Golgi cisternae are the main component of the heavy fraction. A procedure which subjects the Golgi fractions to hypotonic shock and shearing in a French press at pH 8.5 allows the extraction of the content of the Golgi elements and the subsequent isolation of their membranes by differential centrifugation.


The isolation of enteroviruses from cases of acute conjunctivitis. In two epidemics of acute enterovirus conjunctivitis the diagnosis could only be established by the use of human embryonic organ cultures. In one instance cultures of ciliated respiratory epithelium proved sensitive to the virus but similar culture failed to support growth of the virus from the second outbreak which was isolated in organ cultures of conjunctiva. The virus associated with a third outbreak had previously been isolated from the original material by culture in human embryo kidney cells, but it required passage in organ culture for its detection after the specimens had been diluted.


New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis. I. Electron microscope observations. A method is described for measuring and calculating the preexisting surface in uncleaved Xenopus eggs and the rate of surface growth in cleaving eggs. Surface-marking experiments with cytochalasin B-treated eggs show that the unpigmented surface grows by de novo formation and not by expansion of preexisting pigmented surface. The onset of new surface formation during first cleavage was studied by using transmission electron microscope and scanning electron microscope techniques. At 3-4 min and at 7-8 min after the onset of cleavage the eggs were fixed in the presence of ruthenium red (RR). Evidence is presented that unpigmented surface representing new membrane comes into appearance between four and eight min. This surface has a selective binding capacity for RR. Concomitantly with the appearance of new membrane, endoplasmic reticulum (ER) cisternae are in continuity with, and dense cytoplasmic inclusions coalesce with, the membrane along the furrow. The latter give rise to liposome-like bodies. The possibility is discussed that the ER cisternae transport a surface exudate (a carbohydrate complex), that the dense cytoplasmic inclusions represent pools of membrane precursor, and that membranogenesis takes place by direct insertion of pooled precursors into the cell surface. In a second paper, these findings will be correlated with electrophysiological measurements.


Binding of spin-labeled local anesthetics to lobster nerves.


Golgi fractions prepared from rat liver homogenates. II. Biochemical characterization. The three Golgi fractions isolated from rat liver homogenates by the procedure given in the companion paper account for 6-7% of the protein of the total microsomal fraction used as starting preparation. The lightest, most homogeneous Golgi fraction (GF(1)) lacks typical "microsomal" activities, e.g., glucose-6-phosphatase, NADPH-cytochrome c-reductase, and cytochrome P-450. The heaviest, most heterogeneous fraction (GF(3)) is contaminated by endoplasmic reticulum membranes to the extent of approximately 15% of its protein. The three fractions taken together account for nearly all the UDP-galactose: N-acetyl-glucosamine galactosyltransferase of the parent microsomal fraction, and for approximately 70% of the activity of the original homogenate. Omission of the ethanol treatment of the animals reduces the recovery by half. The transferase activity is associated with the membranes of the Golgi elements, not with their content. Galactose is transferred not only to N-acetyl-glucosamine but also to an unidentified lipid-soluble component.


Acute submonary oil embolism and lethal dose study of an oily contrast medium following portal vein administration into dogs.


A study of the ultrastructural organization of cytochrome c-phospholipid membranes as revealed by various experimental treatments.


Release of acetylcholine from perfused cerebral ventricles in unanaesthetized dogs during waking and sleep.


Chemico-biological relationships of follicle stimulating hormone-releasing hormone and luteinizing hormone-releasing hormone.


Gel filtration and preparative free isoelectric focusing of rabbit serum phosphorylphosphatase.


Adenosine 3',5' cyclic monophosphate in Euglena gracilis.


Growth and development in adolescence.

Growth and development in adolescence.


Effect of oxidation on chemical spectral and immunochemical properties of egg yolk lipoprotein.


The molecular and ionic basis of altered myocardial contractility.


Developing a multiphasic rehabilitation program for psychotic patients in a community mental health clinic.


Biliary lipid composition in normalipidemic and prebeta hyperlipoproteinemic gallstone patients. Influence of sucrose feeding of the patients on the biliary lipid composition.


Effect of tricyclic antidepressants on phosphodiesterase. Correlation between aggregability and thrombocyte metabolism.


The effect of 10 days' pyrithioxine administration on sleep cycles in rats.


The effect of psychotropic drugs on phosphodiesterase cAMP, ATPase and on 5'nucleotidase.


Adenofibrosis in the rat liver, with persistence of polychlorinated biphenyls in adipose tissue.


Histiocytosis X histogenetic arguments for a Langerhans cell origin.


Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.


Proceedings: phosphate compounds as bone-scanning agents.


Proceedings: the influence of transplantable tumours on the healing of colonic anastomoses in the rat.


Proceedings: controlled trial of wound spraying with poly-antibiotic or povidone iodine aerosols.


Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency.


Prostaglandins and the kidney.

Prostaglandins and the kidney.


Mechanism of renal handling of angiotensin II in the dog.


Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Influences of aldosterone, norepinephrine, and angiotensin.


Hypertrophy of the ACTH-producing cell following adrenalectomy: a quantitative electron microscopic study.


ACTH and cAMP stimulation of adrenal ribosomal protein phosphorylation.


Cardiac glucocorticoid receptors: the binding of tritiated dexamethasone in rat and dog heart.


Evidence for separate sites of action for the antilipolytic effects of insulin and prostaglandin E1.


Analytical and confirmative techniques for dibenzo-p-dioxins based upon their cation radicals.


Identification of herpes simplex and vaccinia viruses in corneal cell cultures with immunoperoxidase: a light and electron microscopic study.


Kinetics of phosphate incorporation into adenosine triphosphate and guanosine triphosphate in bacteria. Escherichia coli cells were labeled with (33)PO(4) for several generations and then (32)PO(4) was added, samples were taken at various times, and adenosine triphosphate (ATP) and guanosine triphosphate (GTP) were purified from an acid extract. The ratio of (32)P/(33)P in each of the six phosphate species was determined and compared to the ratio expected at isotopic steady state. The rate constants of the simplest network of pools which could explain the data, and were consistent with metabolic pathways, were then calculated. In the range of times studied (30 to 3,000 s at 21.5 C) the following generalizations can be made. (i) The gamma-phosphate at ATP requires 2,200 s to achieve 50% of its final specific activity and behaves as if it were exchanging with another species 4.4 times as large, with this other species turning over in 540 s. (ii) The beta-phosphate of ATP and the gamma-phosphate of GTP are in equilibrium with the gamma-phosphate of ATP. (iii) The specific activity of the gamma-phosphate of GTP lags 66 s behind the gamma-phosphate of ATP. (iv) The alpha-phosphates of ATP and GTP have equal specific activities which lag far behind the other four phosphates. A single precursor pool with a turnover time of 416s fits the data best, although a fair fit can be obtained assuming several sequential precursor pools with much shorter turnover times. These findings are consistent with known biosynthetic pathways and the probable flows through them, including the relationship of nucleotide biosynthesis to ribonucleic acid synthesis and turnover.


Action of ribonuclease T1 on 30S ribosomes of Escherichia coli and its role in sequence studies on 16S ribonucleic acid. Two large ribonucleic acid (RNA) fragments have been obtained from T1-RNase-treated 30S ribosomes of Escherichia coli. One fragment, about 475 nucleotides long, contains all the unique oligonucleotides found by Fellner and associates in sections of 16S RNA designated P, E, E', and K, and one-half the large oligonucleotides of section A. The other large fragment is about 300 nucleotides long and contains the oligonucleotides found in sections C, C', C''. The isolation of these large fragments seems to confirm the arrangement of sections within 16S RNA. There are also recovered from nuclease-treated ribosomes three small fragments, one (120 nucleotides long) from the 5' end, one (26 nucleotides long) from the 3' OH end of the chain, and another section (66 nucleotides long) from the middle of the 16S RNA chain. Small molecular weight material is also generated by nuclease treatment, and about half this material is derived from a region close to the 3' OH end of the 16S RNA chain. This indicates that the most accessible part of the rRNA of E. coli 30S ribosomes is a region 100 to 150 nucleotides long near the 3' end of the chain. A general scheme is proposed to explain the generation of the various-sized RNA products from the rRNA of the 30S ribosome.


The appearance of transient species of cytochrome c upon rapid oxidation or reduction at alkaline pH.


Studies on isopentenyl pyrophosphate isomerase with artificial substrates.


Properties of modified cytochromes. II. Ligand binding to reduced carboxymethyl cytochrome c.


The substrate and anomeric specificity of fructokinase.


Modification of sialyl residues of sialoglycoprotein(s) of the human erythrocyte surface.


Lecithin: cholesterol acyltransferase of human plasma. Role of chylomicrons, very low, and high density lipoproteins in the reaction.


Mitochondrial functions in an ethanol-induced fatty liver.


The cryosurgical treatment of glomus jugulare tumours.


Internal maxillary artery ligation for the removal of juvenile nasopharyngeal angiofibroma.


Invasive pleomorphic adenoma of hard palate.


Effects of early postnatal dietary protein restriction and repletion on porcine muscle growth and composition.


Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3':5'-monophosphate.


Lead-induced inclusion bodies. Solubility, amino acid content, and relationship to residual acidic nuclear proteins.


Ultrastructure of sulfatide storage in normal and sulfatase-deficient fibroblasts in vitro.


Effect of phenobarbital and 3-methylcholanthrene pretreatment on the hepatotoxicity of 1,1,1-trichloroethane and 1,1,2-trichloroethane.


Tracheal soft tissue mass. Case reports.


Prevalence of oropharyngeal excreters of leukocyte-transforming agents among a human population.


Acid-base balance of cisternal and lumbar cerebrospinal fluid in hospital patients.


Epidemic keratoconjunctivitis. A severe industrial outbreak due to adenovirus type 8.


Editorial: Epidemic keratoconjunctivitis and hand washing.


Persistence of poliovirus neutralizing antibodies eight years after immunization with live, attenuated-virus vaccine.


Editorial: Treatment of oat-celled carcinoma of the bronchus.


Pituitary-gonadal relations in female children and adolescents.


Response to 2-deoxy-D-glucose and to glucagon in "ketotic hypoglycemia" of childhood: evidence for epinephrine deficiency and altered alanine availability.


Intestinal mucosa of dogs with ileocystoplasties. Long-term histologic and histochemical changes.


The metabolism of benomyl fungicide in mammals.


Recurrent control from motor axon collaterals of Ia inhibitory pathways in the spinal cord of the cat.


Carcinoma of the rectum in old age.

Carcinoma of the rectum in old age.


Synthesis of isotopically labeled delta2-isopentenylpyrophosphate.


Isolation of rat liver plasma membranes by zonal centrifugation: increased yield with Ca2+.


Separation of cyclic 3',5'-AMP from ATP, ADP, and 5'-AMP by precipitation with inorganic compounds.


A specific micromethod for determination of acetyl residues in proteins.


The temperature dependence of the spectroscopic properties of reduced nicotinamide adenine dinucleotide.


A quick and specific assay for hydroxyproline.


Quantitative determination of reducing sugars, oligosaccharides, and glycoproteins with (3H)borohydride.


Isotopic evidence for futile cycles in liver cells.


Relationship between isotopic reversibility and futile cycles in isolated rat liver parenchymal cells.


Glycogen phosphorylase kinase deficiency: a survey of enzymes in phosphorylase activating system.


On the role of a cuprous ion intermediate in the galactose oxidase reaction.


Development of the cardiac beta adrenergic receptor in fetal rat heart.


The stereospecificity of hydrogen abstraction by uridine diphosphoglucose dehydrogenase.


Subcellular distribution of methylmalonyl CoA carbonylmutase in human liver extracts.


The purification and assay of the prostatic antibacterial factor (PAF).


Energy metabolism in washed human platelets responsive to ADP: comparison with platelets in plasma.


Effect of repeated treatment of rabbit platelets with low concentrations of thrombin on their function, metabolism and survival.


Renal vascular resistance and aortic pressure as determinants of sodium reabsorption.


Application of drug-receptor theories to angiotensin.


Increased renin activity after cold storage of human plasma.


Cytochrome oxidase of skeletal muscle: adaptive response to chronic disuse.


Effects of anions on frog ventricle.

Effects of anions on frog ventricle.


The effects of thyroxine and isopropylnoradrenaline on cytochrome oxidase activity in brown adipose tissue.


Effects of ACTH on melanophores and iridophores isolated from bullfrog tadpoles.


Isolation and characterization of revertant cell lines. 3. Isolation of density-revertants of SV40-transformed 3T3 cells using colchicine.


The role of macrophages in the cytotoxic killing of tumour cells in vitro. I. Primary immunization of lymphocytes in vitro for target cell killing and the mechanism of lymphocyte-macrophage cooperation.


Isolation and characterization of revertant cell lines. IV. Direct selection of serum-revertant sublines of SV40-transformed 3T3 mouse cells.


pH, serum and Zn++ in the regulation of DNA synthesis in cultures of chick embryo cells.


Uridine uptake and its intracellular phosphorylation during the cell cycle.


Inhibition of marrow granulocytic colony formation by phytohemagglutinin.


Improved sensitivity in the measurement of estrogen receptor in human breast cancer.


Persistent infection of mouse cells with Sindbis virus: role of virulence of strains, auto-interfering particles and interferon.


Replication of rhinovirus RNA.

Replication of rhinovirus RNA.


The effect of ethidium bromide on L cells and encephalomyocarditis virus replication.


Circulating interferon in rabbits after administration of human interferon by different routes.


Effect of various inhibitors on the expression of polyoma virus-induced surface antigen in BHK21 cells.


Effect of interferon on virus production from isolated single cells.


The mechanism of interferon action in single cells: accumulation of intracellular virus.


Genetic and structural implications of tryptic peptide analysis of poliovirus structural protein.


Structural proteins of foot-and-mouth disease virus.


Growth and antigenic characteristics of subclones of hamster cells transformed by the Schmidt-Ruppin strain of Rous sarcoma virus.


Inactivation of myxoviruses by lymphoid cells.


Adenohypophysis: ultrastructural cytochemistry. A review.


Relief of massive splenomegaly after irradiation of liver involved by Wilms' tumor.


Electron microscopic studies on various types of inclusions found in autopsy cases. II. Spironolactone inclusion body in autopsy cases and its experimental studies on rhesus monkey.


Cultures of renal biopsies: outgrowth of vacuolated and multinucleated cells.


Plasma renin activity in segmental hypoplasia of the kidneys with hypertension.


A granular cell myoblastoma on the ventral surface of the tongue: a case report.


Vitamin C and chronologic versus bone age.


Prolongation of allograft survival in mice by inducers of interferon.


Enhancement of the dye-exclusion cytotoxic test by insulin and inhibition by cyclic adenosine 3:5-monophosphate and theophylline.


Herpesviruses in renal transplant patients.


Some aspects of food and nutrition in Sierra Leone.


Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis.


Clinical spectrum of infection due to Bacillus species.


Electromyographic and mechanical effects of suxamethonium and tubocurarine on twitch, tetanic and post-tetanic responses.


Disseminated perforating granuloma annulare.


Tissue interrelationships in cutaneous granuloma.


Heterologous protein-RNA interactions in bacterial ribosomes.


On the properties of a membrane-associated protein kinase from Chinese hamster ovary cells.


Effect of acetaldehyde on activity of shuttles for the transport of reducing equivalents into the mitochondria.


Regulation of cholesterol synthesis in normal and malignant tissue.


Gastropod nervous system as a model experimental system in neurobiological research.


The state pharmacy's role in an aftercare program.


Giant islet cell tumor of the pancreas with alpha-like granules. An ultrastructural study.


Burkitt's lymphoma in an Israeli child.

Burkitt's lymphoma in an Israeli child.


Effect of acute neurogenic stress on hypothalamic corticotropin-releasing factor content.


Intracranial reticulum cell sarcoma associated with immunoglobulin A deficiency. A case is reported of a 46 year old woman who died after a five month illness characterized by focal neurological signs, evidence of meningeal irritation, and the finding of `blast' cells in the CSF. Immunoglobulin A was consistently absent from her serum and secretions. Necropsy showed extensive infiltration by a reticulum-cell sarcoma of the subarachnoid space, with tumour nodules on several cranial nerves and tumour infiltration of the tuber cinereum. The significance of the association between immunoglobulin A deficiency and neoplasia is discussed.


Absence of nystagmus during REM sleep in a patient with waking nystagmus and oscillopsia. Polygraphic recording is presented of the sleep pattern in a young male who developed nystagmus and oscillopsia associated with a remittent CNS demyelinating disease. The vestibular nystagmus observed during wakefulness disappeared during all stages of sleep, including rapid eye movement sleep (REM). Since vestibular nystagmus experimentally induced in wakefulness is also absent during all phases of sleep, these findings suggest that during sleep similar suppressive mechanisms are operative.


Cell culture contaminants.

Cell culture contaminants.


Basic principles of a method of nucleoli isolation.


A technique for studying chemotaxis of leukocytes in well-defined chemotactic fields.


Ectopic pinealoma: an unusual clinical presentation and a histochemical comparison with a seminoma of the testis. A patient with ectopic pinealoma first presented with apparent anorexia nervosa and hypernatraemic coma. A history of diabetes insipidus two months previously was not known on admission to hospital. The diabetes insipidus was unmasked by the administration of steroids. Neuroendocrinal and neuropathological aspects of the case are discussed with reference to the march of symptoms due to the growth of the tumour. Histochemical evidence is presented supporting the similarity between ectopic pinealoma and seminoma which suggests that they may more properly be referred to as atypical teratomas.


Divergent action mechanism of cAMP and dibutyryl cAMP on cell proliferation and macromolecular synthesis in HeLa S3 cultures.


The isolation and survival characterization of radiation and chemical-mutagen sensitive mutants of Pseudomonas aeruginosa.


Mutagen sensitivity of Drosophila melanogaster. I. Isolation and preliminary characterization of a methyl methanesulphonate-sensitive strain.


Molecular specificity of 2-aminopurine in Saccharomyces cerevisiae.


The nature of reverse mutations in Drosophila melanogaster.


Enhancement by caffeine of N-methyl-N-nitrosourea-induced mutations and chromosome aberrations in Chinese hamster cells.


Induced discontinuous lesions in the X-chromosome of Drosophila.


DNA repair capacity and susceptibility to chromosome breakage in xeroderma pigmentosum cells.


Absence of Epstein-Barr viral DNA in American Burkitt's lymphoma.


A polyoma-induced hamster tumor cell with altered DNA synthesis in vivo and reduced polynucleotide ligase activity in vitro.


Influence of chlorine dioxide water treatment on numbers of bacteria associated with processed turkey.


Relative concentration and plasma content of yolk lipoprotein precursor in three lines of turkeys.


In vitro studies of human tumor and embryonic tissue.


The lysosomal system in lymphocytes--from cyclic AMP to gene activation.


The effect of LPF (leukocytosis promoting factor) on the kinetics of colony forming cells.


Ultrastructure and cytochemistry of the synapse: isolation and nature of receptors in the central nervous system.


The types and sites of cholinergic receptors.


Effects of drugs on inhibitory synapses.


Biochemistry of synaptic plasticity studied in single neurons.


Cyclic adenosine 3',5'-monophosphate and estrogenic stimulation of uterine metabolism.


Aggregation of human blood platelets by unrelated antigen-antibody reaction: sequence of reaction and role of complement.


Cytologic aspects of abortive transformation in the polyoma virus-hamster cell system.


Thyroid iodine metabolism in vitro. I. Experimental technique.


Experimental infection with mouse adenovirus in adult mice.


Rapid method for the concentration and partial purification of herpes simplex viruses types 1 and 2. Brief report.


DNA-dependent DNA polymerase pattern in noninfected and herpesvirus infected rabbit kidney cells.


Spin label motion in fatty acids.

Spin label motion in fatty acids. Spin labels dissolved in highly purified fatty acid systems exhibit nearly identical tumbling rates in liquid and solid phases. Even though the spin labels do not have the same molecular geometry as the lipid matrix the melting point of the matrix can be inferred by measurements of the temperature dependency of molecular motion.


Inhibition of hog cholera virus by acriflavine. A property shared with bovine virus diarrhoea virus. Brief report.


Preliminary report of results of Harris total hip replacement.


Interim results of Charnley-Müller total hip arthroplasty.


Total hip replacement using the "Brunswik-system".


Evaluation of total hip replacement arthroplasties.


The Stanmore metal on metal total hip prosthesis using a three pin type cup. A follow-up of 100 arthroplasties over nine years.


Results in patients with total hip replacement arthroplasty.


Complications revisited. The debit side of total hip replacement.


Structural studies by proton NMR of cytochrome C-557 from Crithidia oncopelti.


Alteration of subcellular organelles induced by compression.


Direct measurement of the midpoint potential of the primary electron acceptor in Rhodopseudomonas spheroides in situ and in the isolated state: some relationships with pH and o-phenanthroline.


Prostaglandin production by neuroblastoma, glioma and fibroblast cell lines; stimulation by N6,02'-dibutyryl adenosine 3':5'-cyclic monophosphate.


Distinction between oxidizing and reducing sites of cytochrome c by chemical modification with pyridoxal phosphate.


Electron spin resonance spectra of feline NO-hemoglobins.


Primary pulmonary scar carcinomas.

Primary pulmonary scar carcinomas.


Unifying concepts in the response of mammalian cells to stimuli.


Cation-exchange properties of dry silicate membranes.


Role of cyclic AMP in the control of epidermal cell growth and differentiation.


Suppression by vitamins D2 and D3 of hamster cheek pouch carcinoma induced with 9,10-dimethyl-1,2-benzanthracene with a discussion of the role of intracellular calcium in the development of tumors.


Effect of phenobarbital on MHV-3 viral hepatitis of the mouse.


The suprasellar meningioma. A review of the literature and presentation of a series of 31 cases.


Genetics and physiology of colour vision ("my story on colour vision genetics and physiology").


Growth hormone and prolactin in unipolar and bipolar depressed patients: responses to hypoglycemia and L-dopa.


Pseudomonas corneal ulceration: an electron microscopic study.


Corneal collagenases: evidence for zinc metalloenzymes.


Palpebral metastasis of mammary carcinoma: an electron microscopic study.


The bone scintiphotographic examination with 99Tc-tin-pyrophosphate.


The effect of neuraminidase treatment of ribosome-free membranes on their ribosomal reattachment ability.


Similarity of the 0.35 M NaCl soluble nuclear proteins and the nonhistone chromosomal proteins.


Action of the S1 endonuclease from Aspergillus oryzae on simian virus 40 supercoiled component I DNA.


Active subunits of rabbit liver fructose diphosphatase.


Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol.


Subunits of oncornavirus high-molecular-weight RNA. II. Detection of double-stranded-regions in 60S AMV (avian myeloblastosis virus) RNA.


Calorimetric investigation of binding of NADH to pig muscle lactate dehydrogenase.


pH induced increase in cyclic GMP reactivity with cyclic AMP-dependent protein kinases.


Specificity of reticulocyte initiation factors for the translation of globin messenger RNA.


Increased capacity for RNA synthesis in Dictyostelium discoideum nuclei induced by exposure to cyclic AMP or 5'-AMP.


Angiotensin binding to rat adrenal capsular cell suspensions.


Effect of ACTH on biosynthesis of aldosterone and corticosterone by monolayer cultures of rat adrenal zona glomerulosa cells.


Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli.


Utilization of C20-polyunsaturated fatty acids by a yeast fatty acid desaturase mutant.


Effect of poly(ADP-ribose) formation on DNA synthesis and DNA fragmentation in nuclei of rat liver and rat ascites hepatoma AH-130 cells.


Unique nucleotide sequence adjacent to the poly (A) region in yeast RNA.


A qualitative haemoglobin assessment method.


DNA-dependent RNA polymerase in germinating bean rust uredospores.


Effect of aldehyde fixatives on the adenosine phosphatases and ultrastructure of Vitreoscilla.


Tyrosinase from embryonic chick retinal pigment epithelium.


D-galactosamine hepatotoxicity. 3. Normoactive smooth endoplasmic reticulum and modification by phenobarbital.


Phosphorylation and redox states in ischemic liver.


Differential distribution of angiotensin converting enzyme in the anterior and posterior lobe of the rat pituitary.


Proteins in the degenerative retina of C3H mice: deficiency of a cyclic-nucleotide phosphodiesterase and opsin.


Subcellular localization of (14C)adenine derivatives newly-formed in cerebral tissues and the effects of electrical excitation.


Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain.


A rapid fluorometric assay for 2',3'-cyclic adenosine monophosphate 3'-phosphoesterhydrolase.


Glyceride metabolism in cultured cells dissociated from rat cerebral cortex.


Letters: A simple sphingomyelinase determination for Niemann-Pick disease: differential diagnosis of types A, B and C.


The electronic structure of and conformational energy barrier to rotation a round the C-N glycosidic linkage in adenosine-3',5'-cyclicmonophosphate (cyclic AMP) and its phosphonate analog.


A comparative study of electronic and neural networks involved in pattern recognition.


Matching of facilitation at the neuromuscular junction of the lobster: a possible case for influence of muscle on nerve. 1. The facilitation of neuromuscular transmission, which occurs during repetitive activation, was examined in the proximal accessory flexor muscle in walking legs of the lobster using electrophysiological techniques.2. Post-synaptic potentials (p.s.p.s) in different muscle fibres facilitated to markedly different degrees. P.s.p.s in some fibres did not facilitate at all, while in others they increased in size by 20-30 times during stimulation at 20 Hz even though all the excitatory neuromuscular synapses are made by a single axon.3. Stimulation of widely separated groups of synapses on any single muscle fibre evoked p.s.p.s with closely matched facilitation properties. Extracellular p.s.p.s recorded from single synaptic spots showed the same characteristics of facilitation as those of intracellular p.s.p.s in the same muscle fibre, suggesting that individual synaptic contacts on any single fibre are similar to each other.4. Facilitation can be accounted for by an increase in the number of quanta released from the nerve terminals. There is no evidence for an increase in post-synaptic membrane sensitivity.5. Low Ca solutions reduce transmitter release with comparatively little change in facilitation, while Cs solutions increase the size of p.s.p.s without increasing the amplitude of spontaneous miniature potentials. Thus, at poorly facilitating synapses it is unlikely that the absence of facilitation is caused by the saturation of some post-synaptic process.6. It is concluded that the excitatory presynaptic nerve terminals on a single muscle fibre have matching facilitation characteristics. Some interaction between individual muscle fibres and their associated nerve endings may be required to establish or maintain this matching.


Hyperlipoproteinemia. Some basic concepts on diagnosis and management.


The Coronary Drug Project. Findings leading to discontinuation of the 2.5-mg day estrogen group. The coronary Drug Project Research Group.


Shock during oral glucose tolerance testing.


Expression of human red cell acid phosphatase activity in placenta and other tissues.


Properties of human serum factors precipitating bovine enterovirus.


Immunoglobulins and measles antibodies in optic neuritis.


Letter: Intranuclear virus-like particles and cytoplasmic HbAg in chronic hepatitis.


Letter: Viral hemorrhagic cystitis.

Letter: Viral hemorrhagic cystitis.


Tumour specific cell surface antigen and Forssman antigen associated with rat and hamster cells transformed with different strains of avian sarcoma virus.


Isolation of C-type RNA-viruses from stable cell cultures of human tumours.


Early production of Rous sarcoma virus in cocultivated virogenic mammalian and chick embryo cells.


Isozyme patterns of hepatomas and tumour progression.


Cell surface alterations in transformed and mitotic normal cells monitored with plant agglutinins.


Ultrastructural organ-specificity and polymorphism of the cancer cells.


Interactions of normal and neoplastic cells with various surfaces.


Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man.


Hematopoietic colony formation in a macrophage layer provided by intraperitoneal insertion of cellulose acetate membrane.


Liaison nurse: ombudsman for the chronically ill.


Extrachromosomal DNA in bacteria.

Extrachromosomal DNA in bacteria.


Measles and other virus-specific immunoglobulins in multiple sclerosis. Immunoglobulins M and G specific for meales, herpes simplex, and rubella viruses were assayed by the fluorescent antibody method in sera and cerebrospinal fluids (C.S.F.) obtained simultaneously from 30 patients with multiple sclerosis, 30 patients with other neurological diseases, and 30 "normal" control subjects. Sera of 11 out of 30 patients with multiple sclerosis had IgM which reacted specifically with measles virus-infected cells, compared with 2 out of 30 of the patients with other neurological diseases and none of the 30 normal controls. Virus-specific IgM was not found in C.S.F. by this method.The geometric mean titre of measles virus-specific IgG in serum was significantly higher in the multiple sclerosis group than in either control group, and while IgG specific for all three viruses was found in C.S.F., suggesting transfer across the blood-brain barrier, measles IgG predominated.


Letter: Female sterility produced by investigation.


Letter: Protection of cytomegalovirus-infected cells by IgG antibody.


Synovioma in a dog.

Synovioma in a dog.


Distribution of a polychlorinated terphenyl (PCT) (Aroclor 5460) in rat tissues and effect on hepatic microsomal mixed function oxidases.


Studies on nucleotide analogs. I. Synthesis of two 9-alpha-D-mannofuranosyladenine phosphates, and their inhibition of adenylate kinase.


The chemical composition of algal cell walls.


Cyclic AMP and thyroid hormone synthesis. I. Stimulation of the biosynthesis of thyroglobulin-related polypeptides and proteins in bovine thyroid slices.


Editorial: A progress report on lipoprotein phenotyping.


Effect of epinephrine on platelet lipid metabolism.


Glycerol-induced acute renal failure after acute plasma renin activity suppression.


Interaction of cultured human fibroblasts with fibrin: modification by drugs and aging in vitro.


Phosphatidate phosphatase in human platelets.


Recent advances in canine virus research.


Protection of dogs against canine hepatitis with Toronto A26-61 virus (kennel cough isolate) hexon antigen.


Segmental resection for lung cancer. A fifteen-year experience.


Acute obstruction of tricuspid valve by Wilms' tumor.


Case for diagnosis. Wilm's tumor.

Case for diagnosis. Wilm's tumor.


Mutagenicity of dichlorvos and methyl methanesulphonate for Escherichia coli WP2 and some derivatives deficient in DNA repair.


The nature of single-strand breaks in DNA following treatment of L-cells with methylating agents.


Letter to the editor: Dosimetry of the chemical mutagen Ethylmethanesulfonate.


Effects of irradiation on the responses of animal cells to virus.


Virus diseases associated with cutaneous eruptions.


Viruses in human carcinogenesis.

Viruses in human carcinogenesis.


Differences between extracellular and intracellular forms of poxvirus and their implications.


Letter: Insulin activity: the solid matrix.


An electron microscopic study of the neuroglial reaction in the hypoglossal nucleus after transection of the hypoglossal nerve.


The formation and degradation of granules in eosinophil cells.


Studies on the urophysis and the caudal neurosecretory system in a teleost, Ompok bimaculatus (Bloch).


Studies on boar semen. I. A new major defect in the sperm head, the "SME"-defect.


Studies on boar semen. II. Abnormal mitochondrial helix "pseudo-corkscrew sperm" due to ejaculation in the preputial cavity.


Derivatives of aziridine as inactivants for foot-and-mouth disease virus vaccines.


Pediatric oncology.

Pediatric oncology.


The influence of short ether anesthesia on some liver enzyme activities in the rat.


A stable uterine binding protein preparation for the assay of plasma oestriol in pregnancy.


Collagenolytic activity in rheumatoid synovial tissue.


Physical and chemical factors influencing the reliability of the assay of androgens by competitive protein binding.


The effects of adrenalin, glucagon, insulin and dibutyryl cyclic AMP on liver and serum alpha-amylase activities in the rat.


Alcohol dehydrogenase in Mucorales. II.

Alcohol dehydrogenase in Mucorales. II.


Activity and some properties of choline kinase, cholinephosphate cytidyltransferase and choline phosphotransferase during liver development in the rat.


Isolation and characterization of a sialoglycolipid from the sea urchin Strongylocentrotus intermedius.


In vitro and in vivo studies with Epstein-Barr virus (EBV). A review.


The role of the raphe nuclei in the regulation of ponto-geniculo-occipital wave activity.


Epstein-Barr virus: stimulation by 5'-iododeoxyuridine or 5'-bromodeoxyuridine in human lymphoblastoid cells from a rhabdomyosarcoma.


Electrophysiology of the frontal granular cortex. I. Patterns of focal field potentials evoked by stimulations of dorsomedial thalamus in conscious monkey.


Transmitter role of serotonin in identified synapses in Aplysia nervous system.


The effect of number of stimuli and rate of stimulation on the inhibition by PGE1 of adrenergic transmission.


Selective microvascular constrictor actions of some neurohypophyseal peptides.


A controlled trial of a new combined preparation for the treatment of constipation in geriatric patients.


The frequency of excretion of cysts of Entamoeba histolytica in known cases of non-dysenteric amoebic colitis based on 21 stool examinations.


Studies on proteolytic activity of mycoplasmas: the preparation and properties of gelatinolytic enzymes from strains of Mycoplasma arthritidis.


Formation of extracellular haemolysin by Aeromonas hydrophila in relation to protease and staphylolytic enzyme.


Hospital discharge planning: a hospital's responsibility to the patient and the community.


Diagnosis, prognosis and treatment of peripheral neuropathies.


Polishing dental enamel.

Polishing dental enamel.


Effect of dibutyryl cyclic AMP on cell proliferation of adenohypophysis in organ culture. Preliminary report.


Hemoglobin H-beta-thalassemia.

Hemoglobin H-beta-thalassemia.


The problem of pathogenicity in parasitic entamoeba.


Gas-phase electron paramagnetic resonance detection of nitric oxide and nitrogen dioxide in polluted air.


The degeneration and disappearance of the centrioles during the development of the rat spermatozoon.


Localization and correltion of catecholamine-containing cells with adenyl cyclase nd phosphodiesterase activities in the human fetal heart.


X-ray abnormalities in tetra X females. (Report on two cases).


Artificial proteolipids: cytochrome c-detergent complexes soluble in isooctane.


"Super-reduction" of chromatium high-potential iron-sulphur protein in the presence of dimethyl sulphoxide.


The effect of cyclic AMP on anaerobic growth of Escherichia coli.


A synthetic tripeptide which increases survival of normal liver cells, and stimulates growth in hepatoma cells.


A specific glucocorticoid binding macromolecule of rabbit uterine cytosol.


Periodic change in the content of adenosine 3'5'-cyclic monophosphate with close relation to the cycle of cleavage in the sea urchin egg.


A cytoplasmic membrane-associated DNA from rapidly proliferating tissue.


Resolutions and identification of the core deoxynucleoproteins of the simian virus 40.


Cyclic nucleotide-independent protein kinase from pea shoots.


Stimulation of ovarian cyclic guanosine 3',5'-monophosphate levels by the subunits of human chorionic gonadotropin.


Studies on the immunochemical and functional similarities among iron-sulfur proteins involved in mitochondrial steroid hydroxylations.


Carbohydrate composition of lipoprotein apoproteins isolated from rat plasma and from the livers of rats fed orotic acid.


Inhibition of protein synthesis directed by added viral and cellular messenger RNAs in extracts of interferon-treated Ehrlich ascites tumor cells. Location and dominance of the inhibitor(s).


Multiple cytochromes b in Mycobacterium phlei.


A follow-up study of 211 treated male alcoholic addicts.


The stimulation of dopa decarboxylase activity by ecdysone and its enhancement by cyclic AMP in adult mosquitoes.


The phosphorylation of troponin B by phosphorylase b kinase in skeletal muscle of mice carrying the phosphorylase b kinase deficiency gene.


Hypothalamo-hypophysial neurosecretion. II. Hypophysectomy, ACTH and metopiron treatment in Bufo andersonii.


Virulence of E. histolytica strains isolated from cases of amoebiasis in New Delhi, India.


The Poland syndrome-clinical and genealogical data, dermatoglyphic analysis, and incidence.


Morphogenesis of calcium laden cytoplasmic bodies in malakoplakia of the skin. An electron microscopic study.


Location of heme a in cytochrome a. II. Solvent perturbation spectroscopy of ferricytochrome a.


Some characteristics of phosphorylation reactions in rat-liver mitochondria incubated without the addition of adenine nucleotides and their relation to substrate-level phosphorylation.


Juvenile angiofibroma. Report of a case occurring within the mouth.


Regulation of rabbit liver fructose diphosphatase. I. Reversible inactivation by oxidized glutathione.


A hand sign.

A hand sign.


Studies on cyclic nucleotides in the adrenal gland. II. Properties of cyclic AMP dependent protein kinases in the adrenal gland.


Antitumor activity of DL-1-beta-chloroethyl-2-chloromethylpiperidine hydrobromide (CAP-1) on some rodent tumors.


The action of dibutyryl cyclic GMP (N2-2'-O-dibutyryl cyclic guanosine-3',5'-mono-phosphate) on the ileum of guinea pig.


Effect of serotonin, glucagon and other hormones on amylase secretion from rabbit parotid gland.


Specific pressor activity of angiotensins I and II.


The effect of oxytocin on renal blood flow and its distribution in the dog.


Ultrastructure of the abnormal human trophoblast.


A contribution to the knowledge of the hypo-beta-lipoproteinemia.


Paediatric pharmacology.

Paediatric pharmacology.


Lipid- and temperature-dependent structural changes in Acholeplasma laidlawii cell membranes.


Proteins from thermophilic microorganisms.


Action of snake venom hemorrhagic principles on isolated glomerular basement membrane.


Behçet's disease with recurrent facial paralysis.


Calcium binding by a plasma membrane fraction isolated from rat submandibular glands.


A test for space clustering and its application to congenital limb defects in Cardiff.


Letter: Lipoprotein electrophoresis.

Letter: Lipoprotein electrophoresis.


Autotrophic CO2 assimilation and the evolution of ribulose diphosphate carboxylase.


Gel entrapment of antibody: a new strategy for facilitating both manual and automated radioimmunoassay.


Effect of cell chromosome number on simian virus 40 replication.


Nuclear membranes from mammalian liver. VI. Glucose-6-phosphatase in rat liver, a cytochemical and biochemical study.


Growth induction by serum or polyoma virus inhibits the aggregation of trypsinised suspensions of BHK21 tissue culture fibroblasts.


Studies on cellular adhesion in tissue culture. XIIA. Some effects of prostaglandins and cyclic nucleotides.


Contact-inhibited revertant cell lines isolated from SV40-transformed cells. V. Contact inhibition of sugar transport.


A permanent line of macrophages with normal activity in a primary antibody response in vitro.


A Merkel cell nuclear inclusion.

A Merkel cell nuclear inclusion.


Scalp vesicles within the first week of life: a clue to early diagnosis of herpes neonatorum.


Editorial: Leukocyte movement--in vitro and in vivo correlates.


Defect of neutrophil motility in a child with recurrent bacterial infections and disseminated cytomegalovirus infection.


International certificates of vaccination.


Renovascular hypertension secondary to hydronephrosis in a solitary kidney.


Long-term evaluation of single versus multiple courses of actinomycin D therapy of Wilms's tumor.


Lymphocyte inclusions in newborns of mothers with systemic lupus erythematosus.


Vitamin D-induced synthesis of mRNA for calcium-binding protein.


Antibodies to simian C-type virus antigen in sera of gibbons (Hylobates sp.).


Leakage of cyclic AMP from human diploid fibroblasts in tissue culture.


Postpartum bilateral femoral neuropathy.


Choline phosphokinase, phosphorylcholine cytidyltransferase and CDP-choline: 1,2-diglyceride cholinephosphotransferase activity in developing rat lung.


Enhancement of viral infectivity by cytochalasin.


A comparison of the virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus-1A, and poliovirus.


Avian oncornavirus-induced tumor antigens of embryonic and unknown origin.


Rescue of vesicular stomatitis virus from interferon-induced resistance by superinfection with vaccinia virus. I. Rescue in cell cultures from different species.


Rescue of vesicular stomatitis virus from interferon-induced resistance by superinfection with vaccinia virus. II. Effect of UV-inactivated vaccinia and metabolic inhibitors.


Early synthesis of virus-specific RNA and DNA in cells rapidly transformed with Rous sarcoma virus.


DNA replication in SV40-infected cells. IX. The inhibition of a gap-filling step during discontinuous synthesis of SV40 DNA.


Cytotoxic action of spleen lymphocytes to simian virus 40-induced tumor cells.


Tumorigenesis of adenovirus-SV 40 hybrids in hamsters.


Mixed mesodermal tumor of the ovary.

Mixed mesodermal tumor of the ovary.


Fine structure of the differentiating acini in submandibular glands of isoproterenol-treated rats.


Large inclusions in receptor cells of the amphibian lateral line.


The corticotroph of the rat adenohypophysis: a comparative study.


Tracheal obstruction.

Tracheal obstruction.


Cholinergic responses and adrenergic-cholinergic interactions in the mesenteric vascular bed.


Effect of disulfiram on the urinary D-glucaric acid excretion and activity of some enzymes involved in drug metabolism in guinea-pig.


The action of polypeptides, amines and prostaglandins on isolated smooth muscle preparations of seminal vesicles and deferent ducts.


Proceedings: The surgical treatment of nephroblastoma (Wilms' tumor).


Proceedings: Chemotherapy in Wilms' tumor. An appraisal.


Herpesvirus cervicitis and cervical neoplasia. A cytologic review.


Proceedings: Tumors of the adrenal cortex.


Changing pattern of some pathologic parameters of mammary carcinoma.


Myoepithelioma of the palate. Report of a case with histochemical and electron microscopic observations.


Cortisol and growth hormone response to surgical stress during morphine anesthesia.


Hepatocellular carcinoma presenting with pathologic fracture due to bone metastases.


Light and electron microscopic observations on a congenital insulinoma.


Hypoglycemia associated with lipid accumulation in primary hepatocellular carcinoma.


Heart mitochondria oxidations of an Antarctic fish.


Distribution of serum lipoproteins of selected vertebrates.


Suppressive effect of dexamethasone on morphine-induced adrenocorticoidogenesis in rat.


Effect of synthetic corticotropins on human growth hormone secretion.


Effect of ACTH on the phosphorylation of proteins in subcellular fractions of rat adrenal glands.


5Alpha-dihydrotestosterone "receptor" in the rat hypothalamus.


Nuclear and extranuclear mutations in yeast induced by ethyl methanesulfonate.


Poliovirus antibody in milk and sera of lactating women.


Quantification of antipoliovirus antibodies in human and simian sera.


The production of migration inhibitory factor (MIF) in rabbit lymphocytes by other than immunological mechanism.


Combined action of antiamoebic drugs and antibiotics on axenically grown Entamoeba histolytica.


Adenovirus infections in West Bengal. I. Persistence of viruses in infants and young children.


Encephalomyocarditis virus activity in Mus booduga (Gray) in Barur Village (1961-1962), Sagar KFD area, Mysore State, India.


Pseudomonas cepacia tricuspid endocarditis: treatment with trimethoprim, sulfonamide, and polymyxin B.


Sulfonamide structure-activity relationships in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog.


Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.


Letter: On the source of "minor thymine" in DNA from a Novik off rat hepatoma cell line.


Ganglion of the posterior tibial nerve. Case report.


Identification of urinary metabolites of p-phenoxyphenol methanesulfonate in rat and man.


Colorimetric determination of dipyrone.

Colorimetric determination of dipyrone.


Acetonitrile-diatomaceous earth column for separation of steroids and other compounds.


Far advanced malignant external otitis: report of a survival.


Infectious herpesvirus DNA.

Infectious herpesvirus DNA.


Differential inhibition of catabolite-sensitive enzyme induction by intercalating dyes.


Controlled expression of SV40 genome.

Controlled expression of SV40 genome.


Adenine nucleotide-mediated subunit exchange between isoenzymes of glyceraldehyde-3-phosphate dehydrogenase.


Interaction of cytochrome oxidases aa3 and d with nitrite.


Characterisation of the 3'-terminus of Sindbis virion RNA.


Activation of phosphofructokinase by stimulants of cell multiplication.


Activation of methaemoglobin peroxidase by inositol hexaphosphate.


Myopathy associated with Marfan's syndrome. Fine structural and histochemical observations.


Study of long-term anticholinesterase therapy. Effects on neuromuscular transmission and on motor end-plate fine structure.


The effect of sleep on spike-wave discharges in absence seizures.


Patterns of faecal porphyrin excretion in the hepatocutaneous porphyrias. Thin-layer chromatography of their methyl esters.


Extensive resection of primary malignant tumors of the left cerebral hemisphere.


Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations.


Increased detection of occult breast carcinoma after more thorough histologic examination of breast biopsies.


Standardized management of breast specimens recommended by Pathology Working Group, Breast Cancer Task Force.


Cell-mediated immunity to herpes simplex virus in man.


Congenital mesoblastic nephroma of infancy: report of a case with unusual clinical behavior.


Vasoactive substances in the circulation of the pregnant dog during acute fetal ischemia.


Bacteriology and in vitro antimicrobial susceptibility of the Pseudomonas fluorescens group isolated from clinical specimens.


Effect of oxytocin on the perfused human placenta in vitro.


Herpes genitalis treated by photodynamic inactivation of virus.


The metabolic effects of halothane on mammalian hepatoma cells in vitro. II. Inhibition of DNA synthesis.


Decreased cerebrospinal fluid glucose level in herpes zoster meningitis. Report of a case.


On the treatment of rapid eye movement narcolepsy.


Adenyl cyclase in normal and pathologic human muscle.


The behaviour of carcinoma of the large bowel in man following transplantation into immune deprived mice. The growth of carcinoma of the human large bowel was studied in the first 2 passages in immune deprived mice. The tumours were obtained from large bowel resections on 3 people. There was a strong histological similarity between the patient's tumour and the tumour that grew subcutaneously in the mice 2-8 months after implantation. One dissimilarity observed was a higher mitotic index in some of the tumours growing in the immune deprived animals. In the second passage of the bowel tumours, cells were implanted into groups of 8-10 animals in the following sites: subcutaneous, intramuscular, intravenous, intrahepatic, intraperitoneal and intrathoracic. Growth of tumour was observed from all 3 tumours when they were implanted subcutaneously, intramuscularly, intraperitoneally and intrathoracically. Infiltration of muscle by tumour was a frequent finding. Lung metastases developed after intravenous injection of cells in 1 of the 3 tumours. In none of the 3 tumours did growth follow injection of cells directly into the substance of the liver. On no occasions were spontaneous metastases observed.


Immunogenicity of rat hepatoma membrane fractions. The principal expression of immunity elicited in syngeneic rats immunized with rat hepatoma membrane fractions was the development of a tumour specific antibody response. This antibody was demonstrable by membrane immunofluorescence staining of viable hepatoma cells in suspension and the sera exhibited complement dependent cytotoxicity for cultured hepatoma cells. In the absence of complement, however, membrane immune sera were highly "blocking", protecting plated hepatoma cells from attack by sensitized lymph node cells. The cell mediated immune response elicited by hepatoma membrane immunization was weak, as evaluated by the colony inhibitory activity of lymph node cells for hepatoma cells in vitro or the adoptive transfer of immunity with peritoneal exudate cells. Correlated with this overall pattern of immune response, membrane immunization did not elicit tumour rejection reactions. These findings are relevant to current views that humoral factors operate antagonistically to limit cell mediated immunity to tumours. A further relevant feature was the observation that membrane immunization, eliciting a prominent humoral immune reaction, conditioned the recipients so that they subsequently failed to elicit a tumour rejection immunity on treatment with irradiated tumour cells.


Substitution of beclomethasone aerosol for oral prednisolone in the treatment of chronic asthma. In a double-blind study 10 patients with chronic asthma received beclomethasone dipropionate 400 mug daily in a Freon propellant from a pressurized dispenser, and 10 patients received the Freon propellant alone. At the start of the trial each patient was receiving long-term maintenance treatment with oral prednisolone in a dose of 7.5 to 15 mg daily. The daily dose of prednisolone was reduced by 1 mg every four weeks and the patient's progress followed by regular clinical assessment and studies of pituitary-adrenal function. The trial was continued until the dose of prednisolone was reduced to zero or until asthmatic symptoms increased to an unacceptable level.In the 10 patients who received beclomethasone the mean maintenance dose of oral prednisolone was reduced by 5.6 mg/day but in only two cases could this drug be withdrawn completely. In the placebo group the mean reduction in dose was only 1.3 mg, thus there was a significant difference between the two groups (P <0.01). Studies of pituitary-adrenal function showed that a normal adrenal response to tetracosactrin stimulation returned only in the two patients from whom prednisolone was withdrawn.Hence the addition of beclomethasone dipropionate by inhalation to systemic corticosteroid therapy allows useful reductions to be made in the oral maintenance doses of corticosteroid. Reductions must be made with caution since there is wide individual variation in response to beclomethasone and in only a minority of patients can oral treatment by completely withdrawn.


Letter: Type IV hyperlipidaemia in cord blood.


Transplantation of human tumour to immune deprived mice treated with anti-thymocyte serum. Five out of 18 primary explants of human carcinomata obtained at operation have been grown progressively for a minimum of one month in thymectomized, x-irradiated mice reconstituted with syngeneic bone marrow and subsequently treated also with anti-thymocyte serum. All the tumours which proliferated were of gastrointestinal origin, growing locally but not metastasizing although direct invasion of the ribs occurred in one case. No implanted breast carcinomata grew in this system.


Editorial: Neonatal kidney tumours.

Editorial: Neonatal kidney tumours.


Changes in skeletal mineral in patients on prolonged maintenance dialysis. The measurement of bone loss in patients undergoing maintenance dialysis over a period of two and a half years is reported. The tendency to lose bone is a likely event in renal failure, but depends more on the individual patient than on the type of dialysis used, provided that steps are taken to prevent avoidable calcium loss during dialysis. Vitamin D therapy was an important factor in preventing bone loss in some cases. The tendency to lose bone more readily when both kidneys were absent may have reflected a deficiency of 1-25 dihydrocholecalciferol. On the other hand, bone loss was also observed in transplanted patients. The need to measure bone loss at regular intervals once renal failure has been diagnosed is stressed.


Problems of interpretation of laboratory findings in the old.


Letter: Coma and convulsions associated with vincristine therapy.


Pediatric infections with respiratory syncytial virus.


NADH preparations as they affect reliability of serum lactate dehydrogenase determinations.


Respiratory syncytial virus infections in children in Montreal: a retrospective study. Seventy-seven hospitalized children from whom respiratory syncytial virus was subsequently isolated were studied in retrospect. This demonstrated the association of host invasion by this agent with an acute respiratory disease requiring hospitalization for approximately one week.Boys considerably outnumbered girls, the average age was 7.5 months, and in 56% the admission diagnosis was "bronchiolitis". Cough and difficulty in breathing were the most common presenting complaints and "pneumonia" the most common radiological diagnosis. Nearly half the patients also harboured accepted disease-causing bacterial pathogens. All the patients recovered and have remained well.The appearance of the virus in Montreal was seasonal, beginning in late autumn and terminating in early spring.


Residual fluorescence as an index of purity of reduced nicotinamide adenine dinucleotide.


Improved automated determination of bound N-acetylneuraminic acid in serum.


Preparation of amine salts of thymolphthalein monophosphate and their use for measuring phosphatase activity.


Ferric chloride-impregnated silica gel for thin-layer chromatography of steroids.


Proceedings: Comparison between collagenase activity in rectal biopsies and plasma carcinoembryonic antigen (CEA) levels in patients with carcinoma of the colon and rectum.


Proceedings: The association of a specific skin lesion with islet-cell tumours of the pancreas.


Wart-associated antigens. I. Isolation of tissue antigens using antibody immunoadsorbents.


Wart-associated antigens. II. Human immunity to viral structural proteins.


Contraction of isolated human breast cutaneous vascular smooth muscle.


Ultrastructural studies of olivopontocerebellar atrophy.


Adherence of platelets to a collagen-coated surface: development of a quantitative method.


Primary brain and spinal cord tumors induced by human adenovirus type 12 in hamsters.


Glomus tumors in the middle ear. I. An analysis of 46 patients.


Microchemical studies of lipids, proteins and nucleic acids in polyoma virus-transformed hamster astroglia.


Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. A survey conducted by hospitals in the Boston area of 5339 postmenopausal women for the possible influence of estrogen-containing drugs on gall bladder disease, venous thromboembolism, and breast tumors found gall bladder disease to be the  only significantly increased risk (p less than .001).  The relative risk for postmenopausal estrogen users was 2.5 (95% confidence interval was from 1.5 to 4.2), and the incidence rate was 131/100,000 women per year.  Significant associations between estrogen use and the other diseases were not found.


The influence of temperature and fibril stability on degradation of cartilage collagen by rheumatoid synovial collagenase.


Phospholipids in biology and medicine (first of two parts).


Editorial: Collagenase, cartilage and cortisol.


A novel substituted guanidine with high activity in vitro against rhinoviruses.


Histamine H1 and H2-receptors at a ganglionic synapse.


Synthesis of poly(A) in vitro by purified virions of vesicular stomatitis virus.


Affinity of 253Einsteinium for tumour tissue.


Morphological transformation of enucleated Chinese hamster ovary cells by dibutyryl adenosine 3',5'-monophosphate and hormones.


An immunological study of human brain tumors concerning the brain specific protein S-100 and 14.3.2.


Acrylamide neuropathy in rats. An electron microscopic study of degeneration and regeneration.


Peripheral neuropathy in ageing rats fed clioquinol and a maize diet.


The effect of perinatal undernutrition on perineurial diffusion barrier to exogenous protein. An experimental study on rat sciatic nerve.


The hypocalcemic response to protamine as a measure of bone resorption.


Bovine mycoplasmas: cultural and biochemical studies. II.


Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Cellular alterations of the distal bovine pulmonary arteries in hypoxia-induced pulmonary hypertension were studied. These lesions were related to pulmonary hemodynamic changes and contrasted to the cellular response observed in hyperkinetic pulmonary and systemic hypertension as well as other forms of vascular injury. Medial thickening and mild adventitial proliferation with an absence of intimal proliferative lesions related to a progressive increase in mean pulmonary arterial pressure and pulmonary vascular resistance were observed. Smooth muscle and endothelial cells exhibited distinct degenerative alterations in response to the maintained hypertensive state resulting from the lowered alveolar oxygen tension.


Endocrine and immunologic studies in breast cancer.


Collagen-proteoglycan relationships in epiphyseal cartilage. Columnar and hypertrophic zones of calf scapular cartilage were studied before and after extraction with 3 M guanidinium chloride (GuCl) and digestion with enzymes which degrade various components of the extracellular matrix. Morphologic and chemical analysis suggests that there are at least two anatomic pools of proteoglycan in this tissue. One, which resides between collagen fibrils, is extractable with GuCl. Another appears attached to collagen by strong bonds and is apparently not extractable with GuCl. This type of collagen-proteoglycan relationship is possibly restricted to epiphyseal cartilage. The morphology of the lacuna is different in the columnar and hypertrophic zones. Proteoglycans in the distal hypertrophic zone are less resistant to GuCl extraction.


Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.


Inactivation of Herpesvirus hominis types 1 and 2 by silver nitrate in vitro and in vivo. Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 muM AgNO(3). The inactivation of HSV type 1 strains was virtually complete in 10 to 15 min, whereas almost half of the infectivity of HSV type 2 strains survived this exposure. One strain of type 1 inoculated into rabbit eyes was almost completely inactivated by 1% AgNO(3) solution dropped into the eye 20 min later, so that there was markedly reduced viral replication and less corneal herpetic disease. One strain of HSV type 2 in the rabbit eye was not effectively inactivated by 1% AgNO(3). From these results, it seems likely that AgNO(3) instillation into the eyes of a newborn who has passed through a birth canal infected with HSV might prevent eye infection with HSV type 1 but not with type 2. The greater resistance of HSV type 2 strains to chemical inactivation in vitro and in vivo may be of medical concern.


Serum and urinary concentrations of cyclacillin in humans. Cyclacillin is a semisynthetic penicillin produced from the penicillin nucleus (6-aminopenicillanic acid) by acylation with 1-aminohexanecarboxylic acid. The absorption and excretion characteristics of cyclacillin were defined in one completely randomized and three three-way crossover experiments. Mean peak serum cyclacillin levels appeared earlier and were fivefold higher than those obtained with equal doses of ampicillin. High serum cyclacillin concentrations were reached at 0.5 h and by 2 h were lower than ampicillin. Serum ampicillin concentrations peaked at 1.5 h, remaining slightly higher than those for cyclacillin for the next 4.5 h. The mean area for the cyclacillin curve was significantly superior to either of the ampicillin formulations. Mean serum concentrations of cyclacillin exhibited a smooth dose-response, approximately doubling in each instance as the dose was doubled from 250 to 500 and from 500 to 1,000 mg. High concentrations of cyclacillin were also demonstrated in urine. Neither ratio of drug to metabolite in the urine nor the percent of excretion was significantly affected by the dose level. Sixty-seven percent of the drug was excreted unchanged, and 17% was excreted as penicilloic acid, with most of the excretion occurring within 6 h of administration. In subjects given 500 mg of cyclacillin (four times daily) for 6 days, 2% of the drug was excreted as 1-aminocyclohexanecarboxylic acid, and approximately 55% (24 to 91%) was unchanged. Neither formation nor excretion of the former was sex dependent.


Cellular events in protein tolerant inbred rats. I. The fate of thoracic duct lymphocytes and memory cells during tolerance induction to human serum albumin.


Selective cytotoxicity of peritoneal leucocytes for neoplastic cells.


Estrogen-sensitive cells. Hormone receptors in tumors and cells in culture.


Cyclic AMP, pattern formation and movement in the slime mould, Dictyostelium discoideum.


Lag period of action of 25-hydroxycholecalciferol on bone collagen metabolism in vitamin D deficient rats.


Inhibition of cyclic 3',5'-nucleotide phosphodiesterase activity by diuretics and other agents.


Effect of various prostaglandins and serotonin on protein secretion from rat exocrine pancreas.


The rate limiting control of enzymes monoamine oxidase and catechol-O-methyl transferase in the foetus and the adult by adreno-cortical hormones.


Immunohistochemical demonstration of corticotrophic cells concentrated in the rostral zone of the pars intermedia of the mouse hypophysis.


Detection of encephalomyocarditis virus infection in animal cells by gas liquid chromatography.


Influence of suramin on activity of some hydrolytic and oxidative enzymes of pseudoeosinophilic (heterophil) peripheral blood granulocytes in rabbits.


Ultrastructure of cytoplasmic hyaline inclusions in a case of human hepatocarcinoma.


Modification of the acute toxicity of mutagenic and carcinogenic chemicals in the mouse by prefeeding with antioxidants.


Virus-induced premature chromosome condensation (PCC) in single cells and G-bands of PCC-chromatin.


Presynaptic inhibition of adrenergic motor transmission in rat anococcygeus muscle by D-lysergic acid diethylamide (LSD).


The effect of a bradykinin potentiating nonapeptide (BPP9a) on prolonged haemorrhagic shock in dogs.


Cortical pyramidal tract interneurones and their sensitivity to L-glutamic acid. 1. Pyramidal tract interneurones, defined as neurones which are activated synaptically as a result of pyramidal tract stimulation, have been identified in the rat cerebral cortex. The number of evoked spikes depended upon stimulus strength, and stimulation in a specific thalamic nucleus produced a burst of activity lasting for up to 1 sec.2. These cells are readily excited by a brief (50 msec) pulse of glutamate applied by micro-iontophoresis. Other, unidentified cells are not so responsive.3. Synaptically evoked spikes resulting from pyramidal tract stimulation can be blocked by the iontophoretic and I.P. administration of substances shown to antagonize glutamate excitation of cells.4. The results support suggestions that glutamic acid is a neurotransmitter in the cerebral cortex. The evidence presented further indicates that glutamic acid could be the transmitter released by the pyramidal tract.


Involvement of calcium in the inhibitory effects of putative transmitter substances in the cerebral cortex.


Effect of vitamin D3 and other factors on phosphate absorption by the chick.


Activation of prolyl hydroxylase by ascorbic acid.


Use of cross-finger flap for treatment of congenital broad constricting bands of the fingers.


Intramolecular nucleophilic attack of an ureido group on the beta-lactam carbonyl moiety of penicillins.


Different properties of microsomal UDP-glucuronyltransferase in buffalo rat liver and a clonal strain of rat hepatoma cells derived from the same rat strain.


The Russell-Silver syndrome: a nine-year follow-up.


Ménétrier disease and cytomegalovirus infection in childhood.


Letter: Cytomegalovirus infection and toxoplasma.


Multiple joint dislocations and peculiar facies.


Current concepts in management of periampullary carcinoma.


Lymphocytes in some hypereosinophilic states.


Neuromuscular physiology of wound botulism.


Unusual complications of iophendylate injection myelography. Report of a case and review.


Eye disease among American Indians of the Southwest. II. Trachoma.


Comparison of types 1 and 2 Herpesvirus hominis infection of rabbit eyes. II. Histopathologic and virologic studies.


Comparison of types 1 and 2 Herpesvirus hominis infection of rabbit eyes. I. Clinical manifestations.


Treatment of neuropathic conditions of the foot and ankle with a patellar-tendon-bearing brace.


Plasma lipid and lipoprotein abnormalities in patients with malabsorption.


Generation of angiotensin II at peripheral vascular level: studies using angiotensin II antisera.


Effect of propranolol on cyclic AMP excretion and plasma renin activity in labile essentrial hypertension. Labile hypertension is often associated with elevated cardiac output, increased plasma renin activity (PRA) and urinary cyclic AMP excretion in response to upright posture and to isoproterenol. The beta-blocking agent propranolol was demonstrated to be an effective therapeutic agent in this condition. The effect of posture on cyclic AMP, PRA, pulse rate and blood pressure was therefore studied during the administration of propranolol and a placebo in patients with labile hypertension. With the patient on placebo, upright posture induced an increase in pulse rate, cyclic AMP excretion and PRA. Propranolol administration decreased the recumbent and upright blood pressures, pulse rate and PRA. Cyclic AMP excretion remained unchanged in the recumbent position but the postural increase was abolished. No appreciable changes in catecholamine excretion occurred during propranolol administration. Propranolol normalizes some humoral as well as hemodynamic abnormalities of labile hypertension and therefore may be of benefit in long-term treatment and possibly also in the prevention of stable hypertension.


Effects of midbrain tegmental lesions on sleep and regional brain serotonin and norepinephrine levels in cats.


Glomerular basement membrane antigens of Masugi nephritis.


Proceedings: The correlation between redox bioassay and radioimmunoassay for adrenocorticotrophin during insulin hypoglycaemia.


Proceedings: Measurement of plasma adrenocorticotrophin levels in normal and hypopituitary subjects by redox bioassay.


Proceedings: Adrenocorticotrophin (ACTH) and beta-melanocyte-stimulating hormone peptides in tumours associated with the ectopic ACTH syndrome.


Proceedings: Blueprints for the solution of three endocrinological enigmas. The Sir Henry Dale Lecture for 1973.


Pulp reaction to a resin-bonded quartz composite material.


Proceedings: Calcium dependent release of hypophysiotropic substances from nerve-endings (synaptosomes) isolated from the hypothalamus.


Proceedings: Effects in vitro of cytoplasmic and nuclear 5alpha-dihydrotestosterone-receptor complexes on prostatic RNA polymerase activities.


Proceedings: The role of cyclic AMP in the action of androgens on rat ventral prostate gland.


Proceedings: A comparison of the effects of alpha 1-24 adrenocorticotrophin Zn (Tetracosactrin depot) and of substituted alpha 1-18 adrenocorticotrophin on adrenocortical function in normal subjects.


Proceedings: L-DOPA as a test of anterior pituitary function.


Proceedings: A simple enzymic method for the radio-iodination of adrenocorticotrophic hormone.


Proceedings: Effect of protein hormones on the biosynthesis of dehydroepiandrosterone sulphate by human foetal adrenal tissue in vitro.


The co-existence of parathyroid and thyroid disease. I. Primary hyperparathyroidism and thyroid carcinoma.


Angiographic diagnosis of tumors producing hypoglycemia.


Electrical stimulation for relief of pain from chronic nerve injury.


Ther reversal of experimental vasospasm by dibutyryl-3',5'-adenosine monophosphate.


Glucagon stimulation of hepatic gluconeogenesis in rats fed a high-protein, carbohydrate-free diet.


Hormone dependence in breast cancer.

Hormone dependence in breast cancer.


Differences between cytoplasmic glucocorticoid-binding proteins shown by heterogeneity of nuclear acceptor sites.


Calcifying mucin producing adenocarcinoma of stomach.


Proceedings: Lichen striatus.

Proceedings: Lichen striatus.


Computerized axial tomography with the EMI scanner.


Proton radiography in the diagnosis of breast carcinoma.


Viral infections and the surgical patient.


Surgical experience with malignant tumors of the ampulla of vater and duodenum.


The significance of mammography, galactography, and pneumocystography in detecting occult carcinomas of the breast.


Scar cancer of lung complicating rheumatoid lung disease.


Letter: Double-blind trial for treatment of herpes iritis and stromal disease.


Induction of ovulation in patients following removal of a pituitary adenoma.


A comparative quality survey of five common market foods in low and high income economic areas.


Dust exposure in the Vermont granite sheds.


Suxamethonium hyperkalaemia in uraemic neuropathy.


Pulmonary function and roentgenographic changes in granite dust exposure.


Pulmonary function in granite shed workers of Vermont.


Prostaglandins: their actions on the gastrointestinal tract.


Prostaglandins and the central nervous system.


Substances that inhibit the actions of prostaglandins.


Biological aspects of prostaglandins.

Biological aspects of prostaglandins.


Prostaglandins in hematology.

Prostaglandins in hematology.


Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes.


Effects of cobalt on the renal erythropoietic factor and kidney hydrolase activity in the rat.


A thin-layer gel filtration assay of cytoplasmic oestrogen receptors. A possible screening method for hormone dependent tumours. A thin-layer gel filtration system for the assay of oestrogen receptors in target organ tissue samples as small as 50 mg is presented and compared with the sucrose gradient centrifugation method. Only specific high-affinity binding of [(3)H]17β-oestradiol to endometrial cytosol has been observed with the thin-layer gel filtration assay, despite the presence of relatively high levels of nonspecific binding components. The system could be adapted to the clinical determination of oestrogen receptor content in biopsy material from mammary and endometrial tumours and would be of value in predicting hormone dependency.


A study of electron spin resonance spectra of whole blood from normal and tumour bearing patients. Electron spin resonance spectra have been obtained from samples of frozen whole blood or separated blood cells and plasma. Blood samples were obtained from human controls having no diagnosed malignancy and from patients with a variety of benign and malignant tumours.The characteristic spectrum from control blood shows two main lines with g values of 4·2 and 2·049. Several smaller lines can also be observed. The line at g = 2·049 may be due to the copper protein ceruloplasmin. Although no qualitative differences could be found between the spectra from controls and cancer patients, samples from patients with certain types of tumour showed a significant increase in size of the g = 2·049 signal above control values. This was most noticeably the case with Hodgkin's disease and to a lesser extent with cancers of the breast. Squamous cell carcinomata, taken as a group, did not show an elevation in average size of the g = 2·049 signal. In this latter group, however, there were some indications that the effects of chemotherapeutic treatment could be followed during the early stages of such treatment. Examples are given in which onset of treatment with various cytotoxic agents was associated with reduction in size of the g = 2·049 signal.


Early detection of lung cancer. Clinical conference from the University of Iowa College of Medicine.


Sleep recordings from limbic structures in man.


Effect of volume expansion by hyperosmolar and hyperoncotic solutions under constant infusion of angiotensin II on plasma aldosterone in man and its counterbalance by potassium administration.


Male sterility induced by ethanol injection into the vas deferens. At the Johns Hopkins medical institutions in Baltimore, mature male rats were used in an investigation of a simple, nonsurgical technique for achieving sterility.  The technique involved the direct injection of 50 mcl of 95% ethanol directly into the lumen of the vas.  The respective treatments for rat Groups A-F were 1) .9% sodium chloride injected into both vasa, 2) ethanol injected into both vasa, 3) ethanol injected into 1 vas, 4) ligation of both vasa, 5) ligation of 1 vas, and 6) ligation of 1 vas and  ethanol injected into the other vas.  The numbers of animals in the respective groups were 16, 22, 6, 15, 15, and 10.  2 weeks after treatment all of the rats were transferred to individual cages each containing 2 mature females.  At 3 months posttreatment comparisons were made.  In Groups B and F all of the rats were sterile.  In Groups A and C, most of the rats were sterile (12/16 and 5/6, respectively.  Ligations gave expected successes in Group B.  Ethanol acts as a sclerosing agent; the pathological changes are described.  Whether the method provides permanent sterilization is undecided.  Testing with human cadavers has suggested the method is quite feasible for humans.


The menstrual cycle in women treated with d-norgestrel 37.5 micrograms in continuous administration.


Demonstration of HL-A antigens, "species", and "semen"-specific antigens on human spermatozoa. A study by immunofluorescence and immunoelectron microscopy.


Occurrence of HL-A antibodies in sera of sterile women.


Serious pelvic infections associated with intrauterine contraceptive device. A study undertaken to discover whether the incidence and types of intrauterine bacterial growth in IUD users differed from those in nonusers is described.  The study 1)compared the early development of infection in IUD users and nonusers, and 2) looked for a correlation between known serious pelvic infection and IUD use.  Of 235 patients seen for gynecologic examination (131 IUD users and 104 nonusers), 21 users for 6 months or more and 1 user for less than 4 months had foul-smelling leukorrhea, irregular bleeding, or both.  Endometrial cultures were positive in 67% of users, and in 62% of the nonusers.  11 long-term IUD users more than 6 months and 1 nonuser had anaerobic organisms (p less than .01).  Of 31 patients admitted for tubo-ovarian or pelvic abcesses, 17 were IUD users, of whom 9 required hysterectomy.  Earlier recognition of foul-smelling mucoid discharge on the IUD tail, or abnormal bleeding, or both, as a sign of early pelvic infection, followed by removal of the IUD and institution of appropriate antibiotic therapy, might prevent the  more serious sequelae of pelvic inflammation.


The effect of a continuous low dose progestin on tubal and uterine motility.


Tubal occlusion by electrocoagulation under hysteroscopy. A preliminary report.


The correlation of clinical and morphological parameters in induced ovulatory cycles in the human.


Occurrence of spontaneous second pregnancy after delivery of conceptions resulting from ovulation induced by various therapeutic modalities.


The TCu-300 IUD. A preliminary report.

The TCu-300 IUD. A preliminary report.


Efforts to relate spermatozoan motility to fertilizing capacity.


Amebiasis in the tropics. (A historical review).


Hepatitis-associated antigen in chronic liver diseases in Upper-Egypt.


Plasma renin activity: method of measurement and significance in the diagnosis of hypertension.


Tissue culture studies of children's tumours.


Adrenocortical cell deletion: the role of ACTH.


Binding of radioiodinated human placental lactogen to buffalo corpus luteum in vitro.


Age-dependent differences in the binding of (131-I) LH by rat testis homogenates.


Proceedings: Relation of cyclic AMP to sperm motility.


Proceedings: Regulation of steroid secretion in sheep ovarian follicles.


Proceedings: Oestrogen binding to rabbit blastocysts and its possible role in implantation.


Letter: Segmental portal hypertension and islet cell adenoma of the pancreas.


Acute respiratory illness in an American community. The Tecumseh study.


Surgical treatment of lung cancer. Five-year follow-up of 266 patients.


Chemically induced reversion and suppression of methionine-I alleles of Neurospora crassa.


A yeast strain for visual screening for the two reciprocal products of mitotic crossing over.


Liver microsomal assays for evaluating the metabolism of environmental mutagens.


Analysis of virus replication in ageing human fibroblast cultures.


Effect of neuraminidase pretreatment on the susceptibility of normal and transformed mammalian cells to bovine enterovirus 261.


Prolactin secretion is specifically inhibited by nickel.


Induction of Epstein-Barr virus-related membrane antigens by 5-iododeoxyuridine in non-producer human lymphoblastoid cells.


Immunofluorescent antigen associated with Epstein-Barr virus induced by 5-Iododeoxyuridine.


Theta alloantigen on mouse and rat fibroblasts.


Central corticotropin inhibition by arginine vasotocin in the mouse.


Localization of nucleoside diphosphatase in the onion root tip.


Radiology of genitourinary trauma.

Radiology of genitourinary trauma.


Concomitant infection with Entamoeba histolytica and two Shigella strains.


Serological evidence of respiratory syncytial virus infection in sheep.


Biolobical activity of corticotrophin peptides with homo-arginine, lysine or ornithine substituted for arginine in position 8.


Somatotrophic and corticotrophic functions in primary hypothyroidism before and after thyroxine treatment.


Plasma concentration and protein binding of oestriol and its conjugates in pregnancy.


Response of mitochondrial enzymes to decreased muscular activity.


Postmenopausal osteoporosis.

Postmenopausal osteoporosis.


Adrenal steroid secretion in the rabbit: sodium depletion, angiotensin II, and ACTH.


Canine cerebrovascular response to nitroglycerin, acetylcholine, 5-hydroxytryptamine, and angiotensin.


Streptozotocin treatment of tumor hypoglycemia due to primary livercell carcinoma.


Gluconeogenesis in a carnivorous bird (black vulture).


Morphometric study on the distribution of liver necrosis in experimental murine hepatitis by MHV-3 virus.


Alteration of enzyme histochemistry in liver cells attacked by human hepatitis virus.


Gout and its relation to lipid metabolism. I. Serum uric acid, lipid, and lipoprotein levels in gout.


Gout and its relation to lipid metabolism. II. Correlations between uric acid, lipid, and lipoprotein levels in gout.


Ultrastructural aspects of lymphoreticular cells in rheumatoid synovium.


Proceedings: Effect of corticotrophin and oral corticosteroids on nocturnally released growth hormone.


Proceedings: A re-examination of the hypoglycaemia-induced "stress" response of the hypothalamo-pituitary-adrenal axis in patients with rheumatoid arthritis on long-term adrenocorticotrophin (ACTH) therapy.


Value of serum gastrin in the diagnosis of the Zollinger-Ellison syndrome.


Formation of enolpyruvate in the phosphoenolpyruvate carboxytransphosphorylase reaction.


Phosphoenolpyruvate carboxytransphosphorylase. An investigation of the mechanism with 18 O.


Synthesis and biochemical studies of various 8-substituted derivatives of guanosine 3',5'-cyclic phosphate, inosine 3',5'-cyclic phosphate, and xanthosine 3',5'-cyclic phosphate.


Structures of oligosaccharides produced by base--borohydride degradation of human ovarian cyst blood group H, Le-b and Le-a active glycoproteins.


Lateral diffusion, protein mobility, and phase transitions in Escherichia coli membranes. A spin label study.


Comparative electron cytochemical studies of presynaptic and other neuronal mitochondria.


Prostaglandin as a tool for local control of transmitter release from sympathetic nerves.


Acetylcholine metabolism and release at the nerve-electroplaque junction.


Consequences of denervation on the distribution of the cholinergic (nicotinic) receptor sites from Electrophorus electricus revealed by high resolution autoradiography.


Role of amino acids and peptides in synaptic transmission.


Nervous tissue culture--a model to study action and uptake of putative neurotransmitters such as amino acids.


Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.


Histochemical studies on nuclease activity and neoplastic transformation in rat liver during diethylnitrosamine carcinogenesis.


Metastasis in a transplantable mammotrophic pituitary tumor.


Nonfibroblastic origin of foreign body sarcomas implicated by histological and electron microscopic studies.


Transfer of tumor-specific delayed hypersensitivity in vitro to normal guinea pig peritoneal exudate cells using RNA extracts from sensitized lymphoid tissues.


Experimental studies bearing on the question of retrograde spread of Hodgkin's disease via the thoracic duct.


Surface particles on leukemic lymphocytes in humans.


Effect of arginine on the incorporation of 32P into rat liver and Novikoff hepatoma cytosol proteins.


Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.


A study of the macromolecular binding of 67Ga in normal and malignant animal tissues.


Cyclic adenosine 3',5'-monophosphate and cell volume.


Enhancement of lymphoma cell immunogenicity by infection with nononcogenic virus.


Host age dependency of regression of Rous sarcomas of chickens.


Similarity of ribosomal and ribosomal precursor RNA's from rat liver and the Novikoff ascites hepatoma.


Characterization of primary hepatocellular carcinomas and initial transplant generations.


A survey of blood group, serum protein and red cell enzyme polymorphisms in the Orkney islands.


Factors determining the site of synthesis of poliovirus proteins: the early attachment of virus particles to endoplasmic membranes.


A rapidly sedimenting fraction of rat liver endoplasmic reticulum.


Effects of ethidium bromide on growth, chlorophyll synthesis, ultrastructure and mitochondrial DNA in green and bleached mutant, Euglena gracilis.


Ross River virus replication in cultured mosquito and mammalian cells: virus growth and correlated ultrastructural changes.


The interaction of herpes simplex virus with cultures of peripheral nervous tissue: an electron microscopic study.


Induction of interferon in chick cells by polyoma virus.


Surface antigen on hamster cells transformed in vitro by two strains of Rous sarcoma virus.


Infection, haemorrhage and death of chick embryos after inoculation of herpes simplex virus type 2 on to the chorioallantoic membrane.


Interferon bioassay: reduction in yield of myxovirus neuraminidases.


Interferon induction site: poly IC on solid substrate carriers.


The effect of frog virus 3 on the biological activity of various RNA viruses.


Size differences in the ribonucleic acids of feline leukaemia viruses.


Quantitative studies of oncornaviruses in thin sections.


Transfection of chicken fibroblasts with single exposure to DNA from virogenic mammalian cells.


Studies of effects of cyclic adenosine 3',5'-monophosphate in regulation of human hemopoiesis in vitro.


The formation of poliovirus particles in association with the RNA replication complexes.


Reflux esophagitis. A comparison of old and new medical management.


Ceruminoma of external ear. A clinico-pathological study of three cases.


ATP as a nerve transmitter substance.

ATP as a nerve transmitter substance.


Initial steps in the de novo pyrimidine biosynthesis in Ascaris suum.


Chemotaxis, signal relaying and aggregation morphology.


Sexual maturation in juvenile hypothyroidism.


The effect of caffeine on chromosomes of human lymphocytes: a search for the mechanism of action.


5-Methyltryptophan resistance mutations in Escherichia coli K-12. Mutagenic activity of monofunctional alkylating agents including organophosphorus insecticides.


DNA sequence restricted by restriction endonuclease AP from Haemophilus aphirophilus.


Human lymphoid cell transformation by Epstein-Barr virus.


Emerging concepts of platelet function.

Emerging concepts of platelet function.


Antiviral and non-antiviral activity of highly purified interferon.


Hormone-induced desensitisation of hormonal control of cyclic AMP levels in human diploid fibroblasts.


HCG-receptor present in the gonadotrophin insensitive Leydig cell of the immature rat.


Production of Sendai virus for cell fusion.


Studies on the active principle of Solanum malacoxylon.


Low density lipoproteins of chicken, turkey and quail egg yolk.


Effect of temperature on inhibition of chicken liver fructose diphosphatase by adenosine 5'-monophosphate.


Toxicity of various selenium derivatives to chick embryos.


Some physiological responses of turkeys selected for high and low adrenal response to cold stress.


Reversibility of inhibition of chicken liver fructose diphosphatase by adenosine 5'-monophosphate.


Protocollagen proline hydroxylase activity in human gingiva.


Skeletal development of Finnish children in the light of hand-wrist roentgenograms.


Flunitrazepam (Ro 5-4200) and sleep cycle in normal subjects.


Stimulation of cyclic AMP in the isolated perfused rat lung.


Plumbism: adaptive changes in hepatic and renal metabolism.


Peripheral nerve regeneration; sudomotor print test with iodine impregnated paper.


Advanced lung cancer: A clinical trial of radiotherapy plus two drug combination regimens.


Paradoxical bradycardia during REM sleep in periodic catatonia.


Food zealotry and youth: new dilemmas for professionals.


Development of an abortion service in a large municipal hospital. Review of the first year's experience.


Editorial views: Non-respiratory functions of the lung.


Anterior displacement of the inferior vena cava by hepatic masses.


Measurement of the oxidation reduction potential of the EPR detectable active centre of the molybdenum iron protein of Chromatium nitrogenase.


Genetic regulation of a constitutive operon in E. coli B-r.


Polyamines and tumor cells: effect of transformation of chick embryo fibroblasts by Rous sarcoma virus on polyamine levels.


Effect of thyroid hormone analogues on the displacement of 125I-L-triiodothyronine from hepatic and heart nuclei in vivo: possible relationship to hormonal activity.


Diagnosis of tracheal tumors.

Diagnosis of tracheal tumors.


Dietary control of stearyl CoA and alkylacylglycerophosphorylethanolamine desaturases in tumor.


Central vestibular diagnosis. Neurologic examination.


Levels of cyclic AMP in murine L5178Y lymphoblasts grown in different concentrations of serum.


The ocular fixation index.

The ocular fixation index.


Granular cell myoblastoma of the esophagus. Incidence and surgical treatment.


The molecular weight determination of proteins and glycoproteins of RNA enveloped viruses by polyacrylamide gel electrophoresis in SDS.


Cation-dependent light-induced structural changes in visual receptor membranes.


Regulation by beta-adrenergic receptor and muscarinic cholinergic receptor activation of intracellular cyclic AMP and cyclic GMP levels in rat lung slices.


Biosynthesis and characterization of a phosphatidic acid analog containing beta-hydroxy fatty acid.


On the control mechanism of bacterial growth by cyclic adenosine 3',5'-monophosphate.


Promotion of conidia aggregation in Aspergillus niger by cyclic AMP and 5'-GMP.


The in vivo effect of indomethacin and prostaglandin E2 on ACTH and DBCAMP-induced steroidogenesis in hypophysectomized rats.


Activity of tubercidin-, toyocomycin-, and sangivamycin-3',5'-cyclic phosphates and related compounds with some enzymes of adenosine-3',5'-cyclic phosphate metabolism.


Testosterone binding in the chick oviduct.


3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa.


New ATP incorporating activities from rat liver mitochondria: the attachment of a portion of ATP to a pronase-sensitive receptor.


Triacylglycerol secretion in very low density lipoproteins by isolated rat liver parenchymal cells.


Cholesterol in mycoplasma membranes. Composition, ultrastructure and biological properties of membranes from Mycoplasma mycoides var. capri cells adapted to grow with low cholesterol concentrations.


Cholesterol in mycoplasma membranes. Correlation of enzymic and transport activities with physical state of lipids in membranes of Mycoplasma mycoides var. capri adapted to grow with low cholesterol concentrations.


The adverse effects of drugs on the kidney.


Alternatives to institutional care.

Alternatives to institutional care.


Psychogeriatrics.

Psychogeriatrics.


Auditory discrimination during REM and non-REM sleep in women before and after delivery.


There's more than cancer on the brain. Nuclear medicine and the diagnosis of nonneoplastic pediatric brain lesions (or abscess, blood vessel anomaly, or clot?).


Effect of prostaglandin E1 on cholesterol biosynthesis in rat liver.


Prolonged elevation of plasma cortisol levels in dogs treated with an 18 amino acid synthetic corticotrophin.


5-HT hyperpolarization of bullfrog sympathetic ganglion cell membrane.