The inactivation of the acyl phosphatase activity catalyzed by the sulfenic acid form of glyceraldehyde 3-phosphate dehydrogenase by dimedone and olefins.


Vaccination against infectious bovine rhinotracheitis may hamper export trade in breeding cattle.


The incorporation of glucose into brain glycogen and the activities of cerebral glycogen phosphorylase and synthetase: some effects of amphetamine.


Guanine nucleotides and thiourea as modifiers of dynein ATPase and CTPase activity.


Combined contrast and radionuclide angiography of the liver.


Cholinergic control by endogenous prostaglandins of cAMP accumulation under TSH stimulation in the thyroid.


The influence of calcium on the molecular mobility of fatty acid spin labels in phosphatidylserine and phosphatidylinositol structures.


The influence of enzymes on the estrogen receptors of human uterus and breast carcinoma.


The inherited blood factors of the inhabitants of Southern Arabia.


A clinical evaluation of aspiration of cysts of the breast.


A clinicopathological review of 100 cases of primary malignant tumours of the liver. One hundred cases of primary malignant tumour of the liver coming to necropsy in the period 1900-1969 have been reviewed. The overall tumour incidence was 0.46% of all necropsies. The overall tumour incidence in hepatic cirrhosis was 12.3%, but the corresponding male and female incidences were 17.5 and 4.4% respectively. There was no significantly increased tumour incidence in haemochromatosis. An increasing incidence of primary malignant tumours of the liver has been noted since 1940 and appears to be due to a corresponding increase in incidence of hepatic cirrhosis. Hepatocellular carcinomas outnumbered cholangiocarcinomas by 8 to 1, were more common in males than females (6 to 1), and in 77% of cases occurred in cirrhotic livers. Tumours supervened as a complication of macronodular or predominantly macronodular cirrhotic patterns.


Carcinomatous lymph nodes within breast parenchyma.


The interaction of phospholipase C from Staphylococcus aureus and Clostridium perfringens with cell membranes.


Physiological cyclic AMP in Drosophila.

Physiological cyclic AMP in Drosophila.


Physiological characteristics of re-innervation of skeletal muscle in the mouse. 1. Re-innervation of soleus was studied in the mouse after either crushing the sciatic nerve or re-implanting the nerve to soleus outside the original end-plate region.2. During the early stages of re-innervation subthreshold end-plate potentials (e.p.p.s) were recorded in muscle fibres in response to nerve stimulation. Later the e.p.p.s became large enough to evoke action potentials in muscle fibres.3. The rate of recovery of the release of acetylcholine (ACh) as estimated from the quantal content of e.p.p.s was faster when nerves re-innervated the old end-plate region after nerve crush than after re-implantation so that new neuromuscular junctions were formed.4. During re-innervation soleus fatigued more rapidly than normal during repetitive nerve stimulation. The fatigue was due to failure of neuromuscular transmission associated with an impaired release of ACh.5. During re-innervation soleus was supersensitive to ACh until nerve stimulation was capable of evoking action potentials in muscle fibres.


Erosions of the petrous temporal bone.

Erosions of the petrous temporal bone.


Multiple divergent copies of endogenous C-type virogenes in mammalian cells.


Multiple control mechanisms underlie initiation of growth in animal cells.


Apolipoprotein B levels and altered lipoprotein composition in diabetes.


Repair replication and photorepair of DNA in larvae of Drosophila melanogaster. Repair replication of DNA has been studied in first instar larvae of Drosophila melanogaster with isopycnic centrifugation techniques. Larvae were fed BUdR, FUdR, streptomycin, penicillin, and Fungazone for two to four hours prior to exposure to UV, X-rays, MMS, or EMS. Feeding was continued for four hours in the presence of (3)HBUdR and DNA was isolated from whole larvae. Repair replication is stimulated by each of these agents. MMS is about 10 times as potent as EMS in stimulating repair synthesis. A dose of 200 ergs/mm(2) largely saturates the level of repair replication observed after UV irradiation. Repair replication rises between 0 and 80,000 R of X-rays before falling off. Semiconservative synthesis is seriously inhibited above a dose of 40,000 R of X-rays. Photorepair has been detected as a reduction in repair synthesis resulting from post-irradiation exposure to photoreactivating light. The same treatment has no detectable effect on X-ray-stimulated repair replication. Repair replication is insensitive to the presence of caffeine or hydroxyurea during the final incubation, although semiconservative synthesis is strongly inhibited by these agents. A mixture of BUdR and (3)HTdR can be used to replace (3)HBUdR in detecting repair replication.


Respiration for protection against cotton dust.


Of birds and mice and men: comments on the use of animal models and molecular hybridization in the search for human tumor viruses.


Respiratory activities associated with mesosomal vesicles and protoplast membranes of Staphylococcus aureus. Analysis of oxidase and dehydrogenase activities, cytochrome content of mesosomal vesicles, and protoplast membranes showed that the respiratory chain in Staphylococcus aureus is associated predominantly with the protoplast membranes.


Impaired autoregulation of blood flow and glomerular filtration rate in the isolated dog kidney depleted of renin.


Requirement of thymus-derived theta-positive lymphocytes for rejection of DNA virus (SV 40) tumors in mice.


Cortisol dynamics in the adrenal venous effluent.


Acquisition of chick cytosol thymidine kinase activity by thymidine kinase-deficient mouse fibroblast cells after fusion with chick erythrocytes. Chick-mouse heterokaryons were obtained by UV-Sendai virus-induced fusion of chick erythrocytes with thymidine (dT) kinase-deficient mouse fibroblast [LM(TK(-))] cells. Autoradiographic studies demonstrated that 1 day after fusion, [(3)H]dT was incorporated into both red blood cell and LM(TK(-)) nuclei of 23% of the heterokaryons. Self-fused LM(TK(-)) cells failed to incorporate [(3)H]dT into nuclear DNA. 15 clonal lines of chick-mouse somatic cell hybrids [LM(TK(-))/CRB] were isolated from the heterokaryons by cultivating them in selective hypoxanthine-aminopterin-thymidine-glycine medium. LM(TK(-)) and chick erythrocytes exhibited little, if any, cytosol dT kinase activity. In contrast, all 15 LM(TK(-))/CRB lines contained levels of cytosol dT kinase activity comparable to that found in chick embryo cells. Disk polyacrylamide gel electrophoresis and isoelectric focusing analyses demonstrated that the LM(TK(-))/CRB cells contained chick cytosol, but not mouse cytosol dT kinase. The LM(TK(-))/CRB cells also contained mouse mitochondrial, but not chick mitochondrial dT kinase. Hence, the clonal lines were somatic cell hybrids and not LM(TK(-)) cell revertants. The experiments demonstrate that chick erythrocyte cytosol dT kinase can be activated in heterokaryons and in hybrid cells, most likely as a result of functions supplied by mouse fibroblast cells.


The isolation and characterization of plasma membrane from cultured chicken embryo fibroblasts.


The isolation of anaerobic bacteria from wound swabs. The isolation of anaerobic bacteria from routine wound swabs by three procedures was evaluated. Recovery of anaerobic organisms was doubled by immediate incubation of seeded plates, and the recovery could be further dramatically improved by the use of prereduced media, in conjunction with an anaerobic chamber. Recommendations for the treatment of swabs and cultures for anaerobic investigation are made.


The isolation of lung lamellar bodies.

The isolation of lung lamellar bodies.


The isolation of outer and inner mitochondrial membranes.


The isolation of lysosomes from brain.

The isolation of lysosomes from brain.


Persistent infections with herpesviruses.


The isolation of strict anaerobes: the use of an anaerobic cabinet compared with a conventional procedure.


Rabbit brain phosphofructokinase. Comparison of regulatory properties with those of other phosphofructokinase isozymes.


Pituitary adenomas: factors in treatment.


Sensitive in vivo assay for detection of murine leukemia viruses. A test is reported for the in vivo detection of the replicative ability of murine leukemia viruses (MLV) in the BALB/c mouse strain. Growth in the spleen was assayed by the complement-fixation assay for MLV group-specific antigen after injection of newborn mice. Low doses of laboratory-derived and wild-type MLV from cell-culture and animal-grown sources were detected as early as 7 to 14 days postinoculation. The sensitivity of this in vivo test compared favorably with in vitro assays for MLV. In vivo detection of MLV replication was correlated with long-term oncogenicity.


Calcitonin receptors on cultured human lymphocytes.


In vitro association of unique species of cellular 4S RNA with 35S RNA of RNA tumor viruses.


In vitro release of corticosteroids from adrenal glands of obese-hyperglycemic mice (gene symbol ob).


In vitro transfer of cellular immunity against nasopharyngeal carcinoma using transfer factor from donors with Epstein-Barr virus antibody activity.


Calcium binding to brain plasma membranes.


Survival of Clostridium perfringens on chicken cooked with microwave energy.


Marek's disease virus and the herpesvirus of turkeys.


Breakdown of intracellular NAD by streptococcal NAD--glycohydrolase EC 3.2.2.5.


The kinetics of formation and biological activity of native and hybrid molecules of human follicle-stimulating hormone.


Cytokinins: formation of the nucleoside-5'-triphosphate in tobacco and Acer cells.


Basal cell adenoma of the salivary glands.


Renal tubular localization of parathyroid hormone induced urinary cyclic adenosine 3',5'-monophosphate.


The laboratory in the diagnosis and management of viral hepatitis.


Modulation of cyclic-AMP synthesis in the cat superior cervical ganglion by short term presynaptic stimulation.


Regulation of aldosterone synthesis.

Regulation of aldosterone synthesis.


Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma tissue culture cells by serum lipoproteins.


Regulation of muscle phosphorylase b kinase activity by inorganic phosphate and calcium ions. The regulation of the activity of blowfly flight-muscle phosphorylase b kinase by P(i) and Ca(2+) was studied, and the actions of these effectors on the kinases from insect flight and rabbit leg muscles were compared. Preincubation of blowfly kinase with P(i) increased activity severalfold. The effect was concentration-dependent, with an apparent K(m) of about 20mm, and time-dependent, requiring at least 10min for maximal activation. Neither ATP nor cyclic AMP was needed, suggesting that a protein kinase may not be involved. Maximal activation of the insect kinase required Mg(2+) in addition to P(i). The apparent K(m) for Mg(2+) was 3mm. Rabbit leg-muscle phosphorylase b kinase was slightly inhibited, rather than stimulated, by P(i), and was strongly inhibited by K(+), Na(+) and Li(+). At physiological concentrations, Ca(2+) activated the phosphorylase b kinases from both blowfly flight and rabbit leg muscles. However, the responses to Ca(2+) of the enzymes from the two tissues were different. The mammalian kinase had virtually no activity in the absence of Ca(2+), and showed a large increase in activity over a narrow range of Ca(2+) concentrations. Flight-muscle kinase had appreciable activity in the absence of Ca(2+), and had a smaller increase over a wide range of Ca(2+) concentration. The concentrations of Ca(2+) required for half-activation were 0.1 and 1mum for the blowfly and rabbit enzymes respectively. The pH-activity profiles of the non-activated, phosphate- and Ca(2+)-activated kinase revealed considerable enhancement of activity with little, if any, increase in the ratio of activities at pH6.8 to those at 8.2. These results are discussed in relation to the mechanism coupling contraction to glycogenolysis and to the biochemical distinction between asynchronous and synchronous types of muscle.


Enucleated neuroblastoma cells form neurites when treated with dibutyryl cyclic AMP.


Indolent mucoid carcinoma of stomach.

Indolent mucoid carcinoma of stomach. In a review of 574 cases of gastric carcinoma, 50 (8.7%) proved to be mucoid using defined microscopic criteria. Three histological types were recognized: pure signet-ring cell carcinoma (three cases); tumour of mixed pattern (41 cases); and an easily recognized, well differentiated type (six cases). This last group pursued an indolent course and had a mean survival time of nine years compared with mean survival times in the other two groups of five and 18 months respectively.


Accelerated induction to two-kidney hypertension in rats and renin-angiotensin sensitivity.


Restless legs syndrome. Sleep-electroencephalographic and neurologic findings.


Müllerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of müllerian mixed tumor.


Complete nucleotide sequence of the cohesive ends of bacteriophage P2 deoxyribonucleic acid.


Familial hyperlipidemias. Diagnosis and treatment.


Insulin and growth hormone response to an oral glucose load in Ugandan hepatocellular carcinoma patients.


Insulin reversal of alloxan-diabetes induced changes in gingival collagen metabolism of the rat.


Alkaline isomerization of ferricytochrome C from Euglena gracilis.


Insulinomas--problems of diagnosis and management.


Thallium-205 nuclear relaxation and kinetic studies of sodium and potassium ion-activated adenosine triphosphatase.


Virologic studies of multiple sclerosis and other chronic and relapsing neurological diseases.


Virologic studies of progressive multifocal leukoencephalopathy.


Cytological and serological studies of a feline endogenous C-type virus.


Serological survey for antibodies to arboviruses in the human population of Portugal.


Development of a screening technic to monitor a Mycoplasma-free blu:(LE) Long-Evans rat colony.


Development of antibodies to viral and tumor antigens before tumor induction in Syrian golden hamsters inoculated intravenously at 3 weeks of age with SV40.


Development of intranasal vaccination for the immunization of cattle against infectious bovine rhinotracheitis.


Simultaneous stimulation test for the anterior pituitary hormones.


Models for metal-protein interaction: copper(II) complexes with some substituted cyclic dipeptides.


Involutional (physiologic) bone loss in women and the feasibility of preventing structural failure.


Involvement of the adrenal gland in ovulation of the fowl.


Lipolytic activity of adipose tissue. IV. The diacylglycerol lipase activity of human adipose tissue.


Serum lipid and lipoprotein concentrations in a Norwegian population sample.


Serum lipoproteins and the liver, synthesis and catabolism.


Serum 17-alpha-hydroxyprogesterone, progesterone, estradiol, and testosterone in the diagnosis and management of congenital adrenal hyperplasia.


Plasma angiotensin II activity in essential hypertension. Relation with vascular complications.


Plasma clotting of female beagle dogs.

Plasma clotting of female beagle dogs.


Plasma lipoproteins in patients with familial plasma lecithin: cholesterol acyltransferase (LCAT) deficiency--studies on the apolipoprotein composition of isolated fractions with identification of LP-X.


Plasma free fatty acid and triglyceride transport kinetics in man.


Plasma testosterone during nocturnal sleep in normal men.


Plasma triglyceride production in man. Effect of noradrenaline infusion.


Plasma ACTH levels in the human fetus and neonate as related to age and parturition.


Plasma 17-OH-pregnenolone in normal subjects.


Pharmacokinetic function of the pulmonary circulation.


Pharmacological evaluation of a new Ca++ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles.


Pharmacologic regulation of the early steps of purine biosynthesis in Burkitt lymphoma cells and in Ehrlich ascites tumor cells.


Pharmacological properties of a potential tranquilising agent mesylphenacyrazine. II. Changes related to its repeated administration.


Pharmacological studies with alkylsulfonyloxyalkyl substituted and chloroethyl substituted oxazaphosphorine-2-oxides. 1. Communication: relationship between chemical structure and pharmacological action.


Pharmacology of angiotensin.

Pharmacology of angiotensin.


The management and evaluation of the solitary pulmonary nodule.


Rheumatoid arthritis of the elbow: The results of synovectomy.


Chromatoid bodies in somatic cells of the planarian: observations on their behavior during mitosis.


Enzyme activities and glycogen concentration in skeletal muscle in alcoholism. The effect of abstinence and physical conditioning.


Enzyme and ultrastructural characteristics of esophageal columnar epithelium.


Enzyme changes during ageing.

Enzyme changes during ageing.


Cytomegalovirus infection in black children in Durban. A morbid anatomical study.


Parameters influencing the purification of calf uterus estrogen 'receptor' by affinity chromatography.


Asymmetries in Cu(II) impurity complexes in asparagine monohydrate crystals.


Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes.


Dynamic bloodflow studies of space-occupying lesions in the liver.


Dopamine and psychotic states: preliminary remarks.


Vitamin D-resistant rickets and parathyroid adenomas: renal transport of phosphate.


Thiamine deficiency and oxalosis.

Thiamine deficiency and oxalosis. Type I hyperoxaluria results from reduced activity of alpha-ketoglutarate: glyoxylate carboligase, which is necessary for the synergistic decarboxylation of glyoxylate and alpha-ketoglutarate to alpha-hydroxy-beta-keto-adipate. Since thiamine pyrophosphate is a cofactor in the reaction, thiamine deficiency might be expected to result in tissue oxalosis. However, there was no significant increase in the incidence of renal oxalosis in 15 patients with Wernicke's encephalopathy at necropsy compared with controls. It is possible that hyperoxaluria was present in these thiamine-deficient patients but at a urine concentration below that necessary for calcium oxalate deposition. It is also possible that the severity of the thiamine deficit required for hyperoxaluria exceeds that for the neuronal and cardiac manifestations.


Thermogram and mammogram.

Thermogram and mammogram.


Dopaminergic nervous transmission in Parkinson's disease.


Thermoluminescent supralinear response as an optical emission effect for CaF2 Vk-centers.


Low molecular weight nuclear RNA. The 3'-terminal sequence of the U2 RNA.


A tumor associated antigen in human nephroblastomas.


Pleomorphic salivary adenoma of the lower lip: a rare site of occurrence.


Jaw movements and rumen motility as criteria for measurement of deep sleep in cattle.


Chromosomal nonhistone proteins of rat hepatomas and normal rat liver.


A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique.


A simple method for density gradient zonal electrophoresis with imidazole-glycine buffer and its application to a study of cyclic AMP-binding protein.


A simple method for routine determination of adenylate cyclase activity in intact fat cells.


The mutagenic effect of ethylmethanesulfonate on Drosophila melanogaster sperm and spermatids.


Human cancer virus vaccines and the pursuit of the practical.


Human cancer and animal viral oncology.

Human cancer and animal viral oncology.


Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Human primary skin fibroblasts trisomic for chromosome 13, 18, or 21 and diploid human skin fibroblasts were induced for an antiviral response with human interferon. The cells that were trisomnic for chromosome 21 were three to seven times more sensitive to protection by human interferon than the normal diploid or trisomic 18 or 13 fibroblasts. The differential response in trisomnic 21 cells is consistent with the known assignment of the human antiviral gene to chromosome 21.


Human hemopexin. Preparation and magnetic properties.


Human liver nuclear transcortin. Its postulated role in glucocorticoid regulation of genetic activity.


Human IMP dehydrogenase. Kinetics and regulatory properties.


Renin-secreting juxtaglomerular-cell tumour.


Renin, angiotensin II and juxtaglomerular apparatus in liver cirrhosis.


Renin, angiotensin, and aldosterone.

Renin, angiotensin, and aldosterone.


An anaerobic screw-cap culture tube.

An anaerobic screw-cap culture tube.


Coronavirus infection in acute lower respiratory tract disease of infants.


Absence of action potentials in frog slow muscle fibres paralysed by botulinum toxin. 1. As shown previously, slow muscle fibres of the frog develop the ability to produce action potentials in 2 weeks after denervation.2. Normal transmission at the slow fibre neuromuscular junction gives a junction potential of 11 mV average (range 6-20 mV), caused by summation of potentials from several motor axons.3. Botulinum toxin injected intramuscularly into the iliofibularis blocks the neuromuscular junction of slow fibres in 6 days at room temperature. Single nerve stimuli give junction potentials of 0.05 mV average (range 0-1.6 mV). Contraction of slow fibres in response to tetanic stimulation is eliminated.4. No action potentials could be elicited in botulinum treated fibres, even 6(1/2) weeks after injection of toxin. This finding is discussed in relation to the possible involvement of a ;trophic' factor regulating the action potential mechanism in frog slow muscle fibres.


Enhancement of bee venom phospholipase A2 activity by melittin, direct lytic factor from cobra venom and polymyxin B.


Enhancement of simian virus 40 infection in simian and human cells by permissive cell extracts.


Equine infectious anemia.

Equine infectious anemia.


Canine lingual granular cell myoblastoma: a case report.


Advances in ocular therapy: noncorticosteroid anti-inflammatory agents. Fifth annual Jules Stein Lecture.


Bovine lymphosarcoma (leukemia)-a synopsis.


Immune responses to virus induced experimental leukemia and to human leukemia.


Purine nucleotide metabolism in the cat brain after one hour of complete ischemia.


Corynebacterium ulcerans mastitis in a bonnet macaque (Macaca radiata).


Cutaneous afferent stimulation for relief of chronic pain.


Cutaneous Herpesvirus hominis (type 2) infection after renal transplantation.


Cutaneous pseudolymphoma resulting from antigen injections.


The nephrotic syndrome in the first year of life: is a pathologic classification possible?


On influence of aflatoxin B1 on the physical properties of the avian myeloblastosis virus BAI strain A (AMV) and on the biosynthesis of viral nucleic acids.


Laryngeal pleomorphic adenoma.

Laryngeal pleomorphic adenoma.


Typing Herpesvirus hominis antibodies and isolates by inhibition of the indirect hemagglutination reaction. Inhibition of the indirect hemagglutination reaction (IHA inhibition) was compared to several other methods for type-specific identification of Herpesvirus hominis (HVH) antibodies and isolates. The method appears to have the greatest value for typing antibodies for HVH type 1 and HVH type 2 in human sera; identification of antibody type was relatively simple and results were definitive. The IHA-inhibition test permitted serological diagnosis of HVH type 2 infection in three young adults with meningoencephalitis, thus extending the mounting evidence that nervous system involvement with this virus type is not limited to neonatal infections. II/I indexes of neutralizing or IHA antibody gave an accurate indication of the presence of HVH type 2 antibody in those sera containing type 2 antibody by IHA inhibition, but they indicated the presence of HVH type 2 antibody in one-half or more of the sera shown to contain only HVH type 1 antibody by IHA inhibition. For typing HVH isolates, the IHA-inhibition test gave results identical to those obtained by direct fluorescent-antibody staining using cross-absorbed conjugates, but the IHA-inhibition test was much more cumbersome and time-consuming to perform than was direct fluorescent-antibody staining. A microneutralization technique for virus typing also gave results identical to those obtained with direct fluorescent-antibody staining and IHA inhibition. However, typing HVH isolates by plaque size or the differential effect of incubation temperature was found to be less definitive and accurate.


Meningeal reactions seen with myodil myelography.


An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients.


Chronic destructive polyarthritis due to pyrophosphate crystal arthritis ("pseudogout" syndrome).


Ammonia formation in brain slices.

Ammonia formation in brain slices.


Chronic effects of botulinum toxin on neuromuscular transmission and sensitivity to acetylcholine in slow and fast skeletal muscle of the mouse. 1. A sublethal dose of botulinum toxin (type A) was injected into the muscles of one hind limb of the mouse causing local paralysis.2. Neuromuscular transmission and muscle sensitivity to acetylcholine (ACh) were studied in vitro in soleus and extensor digitorium longus (EDL) from 6 hr to 4 months after the injection of toxin.3. Both soleus and EDL failed to respond to nerve stimulation within 6 hr of the injection of toxin.4. In muscle fibres in which neuromuscular transmission was blocked, subthreshold end-plate potentials (e.p.p.s) were recorded. The amplitude of the e.p.p.s increased during recovery from the effects of the toxin and both muscles contracted in response to nerve stimulation after 2-3 weeks.5. For about 2 months muscles fatigued more rapidly than normal during repetitive nerve stimulation because of the low quantal content of e.p.p.s.6. Supersensitivity to ACh developed in 3-5 days and persisted after the return of neuromuscular transmission. Muscle sensitivity to ACh became normal when the rate of fatigue during nerve stimulation was normal.


Subunit structure of the apoprotein of human serum low density lipoproteins.


Meconium corpuscles in intestinal epithelium of fetal and newborn primates.


Melanocyte function: influence of cyclic adenosine monophosphate.


Adrenocorticotropin stimulation of cyclic adenosine 3', 5'-monophosphate formation in isolated rat adrenal cells. The role of membrane sialic acid.


Immunologic evidence for horizontal transmission of MTV.


Immunofluorescent demonstration of double-stranded RNA and virus antigen in RNA virus-infected cells.


Immunological destruction of herpes simplex virus I infected cells.


Immunological intervention in neoplasia.


Immunotherapy of guinea pig cancer with BCG.


An anomaly of the genetic regulation of the de novo pyrimidine pathway in the plant Arabidopsis.


Toxins and enzymes of coagulase negative staphylococci isolated from human infections.


A sensitive method for the separation and quantitation of (14C)proline and (14C)hydroxyproline from the collagen of rat uterus.


Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. VII. Stimulation of benzphetamine N-demethylation by lipid and detergent.


Demonstration of collagenase activity in rat liver homogenate.


Demonstration of low-titer anti-Pr cold agglutinins.


Demonstration of the in vivo action of pepstatin: effects on plasma angiotensin II concentration.


Diagnosis of salivary gland tumors.

Diagnosis of salivary gland tumors.


Potential generation in bilayer lipid membranes in the NADH-flavin mononucleotide-ubiquinone-6-O2 system.


Potential X-ray contrast agents. 3. Synthesis of some derivatives of iodomethanesulphonic acid and tris-iodomethylacetic acid.


Infantile type of so-called neuronal ceroid-lipofuscinosis.


An ontogenic study on the effect of catecholamine receptor-stimulating agents on the turnover of noradrenaline and dopamine in the brain.


Attention in the cat: electrophysiological and behavioural studies.


Mutants of the N-3 R-factor conditionally defective in hspII modification and deoxyribonucleic acid-cytosine methylase activity. The N-3 drug resistance (R) factor specifies a deoxyribonucleic acid (DNA)-cytosine methylase and a DNA restriction-modification (hspII) system. We have isolated three independent mutants that are conditionally defective in their ability to modify bacteriophage lambda and to methylate DNA-cytosine residues. The ratio of 5-methylcytosine to N(6)-methyladenine in bacterial DNA and in the DNA of phages lambda and fd was determined after labeling with [methyl-(3)H]methionine at various growth temperatures. Although the ability of the wild-type N-3 factor to modify phage lambda and to methylate DNA-cytosine residues was unaffected with increasing temperature, two of the mutants exhibited a parallel loss in modification and cytosine methylation ability. The ability of the third mutant to carry out these functions was dependent on the presence or absence of an amber suppressor mutation in the host genome. These results offer further support for the notion that hspII modification is mediated by a DNA-cytosine methylase. Evidence is also presented that the modification methylase is responsible for the in vivo methylation of phage fd DNA (which is not subject to hspII restriction in vivo).


Ribonuclease H activities associated with Herpes simplex virus.


Ice nucleation induced by pseudomonas syringae. Broth cultures of suspensions of Pseudomonas syringae isolated from decaying alder leaves (Alnus tenuifolia) were found to freeze at very warm (-1.8 to -3.8 C) temperatures. The initiation of freezing appears associated with the intact cell and not with extracellular material. Chemical treatments and physical destruction of the cell destroy activity. Bacteria must be in concentrations of approximately 10(6)/ml before freezing at warm temperatures occurs.


The nucleotide sequence of 5 S rRNA from the blue-green alga Anacystis nidulans.


An unusual karyotypic observation on cultured cells from an owl monkey (Aotus trivirgatus). A cell line, established from a pathological lymph node of an owl monkey, Aotus trivirgatus s.sp. trivirgatus, was found to have two cell populations distinguished from one another by chromosome number. The normal karyotype was present in the population of cells with 54 chromosomes; the other cell population, with 55 chromosomes, possessed a normal karyotype but with one additional abnormal chromosome. The significance of this extra chromosome is discussed.


Demonstration of an enhanced alpha-adrenergic response in human adipose tissue when incubated in presence of Li+ instead of Na+.


Amino acid transport and staphylococcal membrane vesicles.


Microbial penicillin acylases.

Microbial penicillin acylases.


Protocatechuate 3, 4-dioxygenase. Cobalt substitution for iron.


Histochemical data on the sebaceous glands in the lips of the marmoset (Callithrix jacchus).


Histochemical localization of phosphohydrolases in testes of man and rat.


Histochemical studies of hydropic degeneration of the rat liver induced by carbon disulphide.


Histochemical observations on the human foetal testis with reference to steroid hormone synthesis.


Dissociation properties of aspartokinase I-homoserine dehydrogenase I extracted from a missense mutant of E. coli K12.


Dissociation of growth hormone and prolactin secretion in Parkinson's disease following chronic L-dopa therapy.


Histocompatibility studies on the husband-wife pair with trophoblastic neoplasia.


Glucocorticoid binding in the chicken liver cytosol.


Glucocorticoids and hCG sensitivity of rat testicular Leydig cell.


Chemodectomas.

Chemodectomas.


Methods for preparation of secretory granules from anterior pituitary glands.


Introduction of a cross-infection rate in children's wards and its application to respiratory virus infections. Statistical methods are described in detail for the calculating and comparing of cross-infection rates. In addition the use of these rates has been extended to study the influence of age and of different virus types on susceptibility to cross-infection in children's wards.


Introduction to virus-caused cancer: type C virus.


Use of streptomycin and cyclic adenosine 5'-monophosphate in the isolation of mutants deficient in CAP protein. A method is described for selective isolation of mutants deficient in CAP protein necessary for the expression of catabolite-sensitive operons in Escherichia coli.


Neurofibromatosis (Recklinghausen's disease) with gastrointestinal and uterine manifestations: report of a case.


Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat.


Onocogenic conversion of normal cells by inactivated herpes simplex viruses.


Pathogenic role of cyclic AMP in the impairment of urinary concentrating ability in acute hypercalcemia. A possible association between the impairment of urinary concentrating ability and an impairment of the vasopressin-dependent cyclic AMP system in hypercalcemia was investigated in rat kidneys both in vivo and in vitro. The increases of urinary osmolality and negative free water clearance and the increase of urinary cyclic AMP excretion by vasopressin injection were significantly less in the hypercalcemic rats than in the control rats. The increase of cyclic AMP concentration by vasopressin in renal medullary tissue was significantly less in the slices obtained from the hypercalcem'c rats than in those obtained from the control rats. The activation of adenylate cyclase by vasopressin was significantly less in the group with an increased concentration of calcium in media than the control group, but phosphodiesterase activity was not affected by calcium concentration in the media. These data suggest that the impaired urinary concentrating ability in hypercalcemic kidneys is due at least in part to the direct inhibitory effect of calcium on the vasopressin-dependent cyclic AMP system at the level of adenylate cyclase in renal medulla.


Pathogenicity of five Asian strains of Entamoeba histolytica in laboratory rats.


Biological properties of extracellular proteins from staphylococcus.


Amniography for the detection of fetal myelomeningocele.


Angiography in radiation "hepatitis".

Angiography in radiation "hepatitis".


Neurohypophyseal hormones and analogues: rat pressor potency versus contractile potency on rat arterioles and arteries.


Steroid binding in polyacrylamide gels. Quantitation at steady state conditions.


Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases.


Steroids, hypertension, and fluid retention in the genesis of postoperative seizures with inflammatory bowel disease in childhood.


Sterol compositions of echinoids (sea urchin, sand dollar and heart urchin).


Steroid production by the isolated rabbit ovarian follicle. II. Effects of peptide hormones.


Radiological examination of the stomach with a potentiated double contrast technique.


Radiological follow-up examination of the mineral salt content in the various vitamin D-resistant forms of rachitis of renal origin.


Histologically different, synchronous, bilateral carcinoma of the male breast (a case report).


Aetiology and epidemiology of viral croup in Glasgow, 1966-72. A retrospective study of 258 children admitted to Ruchill Hospital, Glasgow, with croup between 1966 and 1972 indicated that the viruses most frequently associated with the syndrome were parainfluenza types 1 and 3 and influenza A. Most cases were admitted in the late autumn and winter months, with a small peak in May and June. This seasonal distribution mirrored the circulation of the main causative agents in the community, parainfluenza 1 being principally associated with the autumn cases, influenza A the winter cases and parainfluenza 3 the summer cases. Two of these ;croup associated' viruses showed regular periodicity, parainfluenza 1 occurring biennially in even years and influenza A in most years. The periodicity of parainfluenza 3 is as yet undetermined.


Glycolysis in the digestive gland of healthy and parasitized Littorina saxatilis rudis (Maton) and in the daughter sporocysts of Microphallus similis (Jäg.) (Digenea: Microphallidae).


Pathology and pathogenesis of the common diseases of the respiratory tract of cattle.


Radiolysis of biochemical systems using adamantane as an isolation matrix.


Thecoma with extensive calcification.

Thecoma with extensive calcification.


Sarcoma and transformation-defective viruses produced with infectious DNA(s) from Rous sarcoma virus (RSV)-transformed chicken cells.


Thymoma with systemic lupus erythematosus, red blood cell aplasia, and herpesvirus infection.


Poliomyelitis in the German Federal Republic. Sporadic diseases by imported wild poliovirus.


Carbon dioxide laser in head and neck surgery.


Fusion of chicken erythrocytes by phospholipase C (Clostridium perfringens). The requirement for hemolytic and hydrolytic factors for fusion.


Action of metabolic hormones on the fine structure of rat liver cells. III. Effects of adrenalectomy and administration of cortisone.


Fusion of intact human erythrocytes and erythrocyte ghosts. Sendai virus is able to induce the fusion of human erythrocytes. Bivalent cations or ATP are not essential for polyerythrocyte formation. High fusion indices were obtained when Sendai virus was added to cells incubated in the presence of both EDTA and iodoacetic acid. Human erythrocyte ghosts prepared by gradual hemolysis still retain the potential to undergo virus-induced fusion. Fusion of human red blood cells without the addition of viruses was obtained by incubation of erythrocytes at pH 10.5 in the presence of Ca(++) (40 mM) or by addition of phospholipase C Clostridium perfringens preparations to cells previously agglutinated or polylysine.


Action of thyrotropin on phosphate incorporation into thyroid proteins in vitro.


Proton relaxation studies of diphosphopyridine coenzymes.


Rational basis for an immunization program against the common diseases of the bovine respiratory tract.


Hormonal effects of synthetic ACTH analogues.


Hormonal control of the potassium level in isolated rat liver cells.


Neuronal storage disorder with chorea and curvilinear bodies.


Hormonal regulation of amino acid accumulation in human fetal liver explants. Effects of dibutyryl cyclic AMP, glucogon and insulin.


Hormone synthesis and release from human fetal adenohypophyses in vitro.


Components of the renin-angiotensin system in the rat during development.


Actions of excitatory amino acids and their antagonism.


Prisons, adolescents, and the right to quality medical care: the time is now.


Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative.


Response to LH-RH in women before and after treatment with prednisone.


Responses of antidromically identified preoptic neurons in the rat to neurotransmitters and to estrogen.


Responses of guinea pig umbilical vasculature to vasoactive drugs.


Cyclopenta(f)isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 3. Interaction of 6-carbamylmethyl-8-methyl-7H-cyclopenta(f)isoquinolin-3(2H)-one with deoxyribonucleic acids and polydeoxyribonucleotides.


Macrophage spreading in vitro. III. The effect of metabolic inhibitors, anesthetics and other drugs on spreading induced by subtilisin.


Hydrophobic interaction of human interferon with concanavalin A-agarose.


Radioreceptor and radioimmunoassay quantitation of human growth hormone in acromegalic serum: overestimation by immunoassay and systematic differences between antisera.


Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid.


Radioreceptor assay for somatomedin A.

Radioreceptor assay for somatomedin A.


Editorial: Cytomegalovirus again.

Editorial: Cytomegalovirus again.


Editorial: Angiotensin inhibition.

Editorial: Angiotensin inhibition.


Editorial: Diffuse interstitial pulmonary calcification.


Editorial: Some newer endocrine aspects of breast cancer.


Performance and concentration of airway washings of chickens.


Conformational change associated with the acylation of alpha-chymotrypsin by N-acetyl-L-phenylalanine methyl ester.


Conformational changes induced in Escherichia coli ribosomes by streptomycin. A spin label study.


Factors influencing pituitary glycogen metabolism and gonadotropic hormone release. I. Luteinizing hormone-releasing hormone. The way in which luteinizing hormone (LH) and follicle stimulating h ormone (FSH) are related to pituitary glycogen metabolism is investigated by measuring pituitary glycogen content and the activity of glycogen synthetase and glycogen  phosphorylase in LH-releasing hormone (LH-RH) treated rat pituitaries.  The presence of LH-RH (15 ng/flask) resulted in a significant (p less than .05) release of LH and FSH after 4 hours of incubation.  Pituitary LH content was also raised (p less than .05).  3 ng of LH-RH increased pituitary cyclic adenosine monophosphate (AMP) content by 475% in 10 minutes of incubation.  Glycogen phosphorylase was converted to its active form with 1-10 ng LH-RH per flask; this glycogenolytic activity occurred within 5 minutes (p less than .01) and was also induced by cyclic AMP in the presence of theophylline.  The forms of glycogen synthetase did not appear to be affected by LH-RH or cyclic AMP.  It is concluded that pituitary glycogen may be an energy source for release of gonadotropins via LH-RH.


Conformational mobility of the pyrrolidine ring of proline in peptides and peptide hormones as manifest in carbon 13 spin-lattice relaxation times.


Factors influencing pituitary glycogen metabolism and gonadotropic hormone release. II. A role of prostaglandins.


Osteosclerotic myeloma with peripheral neuropathy.


Adenosine 3',5'-cyclic monophosphate-deficient mutants of Vibrio cholerae. Two adenosine 3',5'-cyclic monophosphate (AMP)-deficient mutants of Vibrio cholerae (biotype El Tor) were successfully isolated by nitrosoguanidine treatment followed by pencillin screening for pleiotropic sugar-negative clones. Exogenous cyclic AMP is required for the fermentation of sucrose, trehalose, fructose, maltose, and mannose but not of glucose, as well as for the formation of normal flagella and specific somatic antigens. A striking characteristic of the mutants is their growth behavior at higher temperatures. They cannot grow on TCBS selective plates at 37 C or higher unless they are provided with a supply of exogenous cyclic AMP, although they are capable of producing colonies on the same medium, even without cyclic AMP, at temperatures lower than 30 C. Since the mutants are converted to spheroplasts, spindle forms, and spiral filaments in cyclic AMP-free media at 37 C, and this phenomenon is stopped by the addition of cyclic AMP or a combination of 20% sucrose and 0.2% magnesium chloride, it is assumed that cyclic AMP is essential for the synthesis of the cell wall of V. cholerae at higher temperatures.


Adenosine 3':5'-monophosphate-dependent protein kinase-catalyzed phosphorylation reaction and its relationship to calcium transport in cardiac sarcoplasmic reticulum.


Adenosine 5'-triphosphate release and membrane collapse in glycerol-requiring mutants of Bacillus subtilis. Glycerol-requiring mutants of Bacillus subtilis could not sporulate in nutrient sporulation medium even when additional glycerol was added from the beginning of growth. Sporulation could be partially restored either by the frequent addition of small amounts of glycerol during the developmental period or by the single addition of both 10 mM glycerol and 10 mM malate. But sporulation could be completely restored by the addition of 50 mM glycerol-phosphate from the beginning. At the end of growth of the glycerol mutants in nutrient sporulation medium, the cell membrane collapsed and separated from the cell wall, and much of the cellular adenosine 5'-triphosphate was released into the medium. These observations were made in two glycerol mutants, one derived from strain 168 containing glycerol-teichoic acid in the cell wall and the other derived from strain W23 containing ribitol-teichoic acid.


Glycosyl glycerides.

Glycosyl glycerides.


Mannosyltransferase activity in calf pancreas microsomes. Formation from guanosine diphosphate-D-(14C)mannose of a 14C-labeled mannolipid with properties of dolichyl mannopyranosyl phosphate.


Hypnotic suggestions for learning during stage I REM sleep.


A protein-bound form of porcine renal renin.


Pronounced antiviral activity of human interferon on bovine and porcine cells.


Enzootic Brucella canis--an occult disease in a research canine colony.


An "outbreak" of juvenile diabetes mellitus: consideration of a viral etiology.


The oxidation state of copper in resting tyrosinase.


Hydroxylysine glycosides in the collagen of normal and scarred rabbit corneas.


Sleep deprivation in cattle.

Sleep deprivation in cattle.


Improved methods for the study of drug effects on purine metabolism and their application to nebularine and 7-deazanebularine.


Sleep in hypnosis: a pilot EEG study.

Sleep in hypnosis: a pilot EEG study.


Idiopathic sexual precocity in a boy with growth hormone, prolactin and thyrotropin deficiencies.


The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies.


Independence of cholesterol and fatty acid biosynthesis from cyclic adenosine monophosphate concentration in the perfused rat liver.


C-type viral particles in a urinary bladder neoplasm induced by Schistosoma haematobium.


Independent dibutyryl cyclic adenosine monophosphate stimulation of human chorionic gonadotropin and estrogen secretion by malignant trophoblast cells in vitro.


Subependymal veins and ventricular tumors.


Polypeptide composition of urea- and heat-resistant mutants of poliovirus types 1 and 2. Five urea-resistant and two heat-resistant mutants of poliovirus types 1 and 2 were isolated and their structural and nonstructural polypeptides compared to those of their wild-type, parental strains in an attempt to correlate mutant phenotypes with alterations in specific capsid polypeptides. Four of the seven mutants were found to contain polypeptides which differed in molecular weight from their respective parental viruses. However, resistance of virions to heat- or urea-inactivation could not be attributed to changes in particular capsid polypeptides because alterations were detected in all but one of the capsid components. For two of the urea-resistant mutants and one heat-resistant mutant, no differences were found in the molecular weights of the capsid and noncapsid polypeptides. These results, and the fact that at least 12 selective treatments were required to obtain stable mutants, indicate that: (i) such phenotypes probably can be expressed by mutations affecting one or more of the larger capsid polypeptides, and (ii) such phenotypes reflect multiple mutational steps.


Polypeptides of Moloney sarcoma-leukemia virions: their resolution and incorporation into extracellular virions.


The peribrachial region of cat. II. Distribution of acetylthiocholinesterase and monoaminoxidase, with special reference to the locus coeruleus.


Phosphate metabolism in blue-green algae. I. Fine structure of the "polyphosphate overplus" phenomenon in Plectonema boryanum.


Phospholipid exchange between membranes. Purification of bovine brain proteins that preferentially catalyze the transfer of phosphatidylinositol.


Phosphorylation of proteins of ribosomes and nucleolar preribosomal particles in vivo in Novikoff hepatoma ascites cells.


Ectopic fetal adrenal cortex in the lung of a newborn.


A rapid, simple and reliable method for the screening of potential antiviral compounds in vitro.


A rapid micromethod for the determination of nitrogen and phosphate in biological material.


Cytoplasmic alterations of hepatocytes in rainbow trout (Salmo gairdneri) induced by cyclopropenoid fatty acids.


The preparation and characterisation of a water-soluble coenzymically active dextran-NAD+.


The presence of bound cyanide in the naturally inactivated form of nitrate reductase of Chlorella vulgaris.


The presence of 4-selenouridine in Escherichia coli tRNA.


Derepression of nitrogenase in Azotobacter.


The process of establishing a collaborative program between a mental health center and a public health nursing division: a case study.


Incipient pulmonary emphysema. II. Genetics and biochemistry.


The properties of water in biological systems.


The purine DNA base cation and anion radicals: an e.s.r. study.


The pyrophosphate exchange reaction of histidyl-tRNA synthetase from Salmonella typhimurium: reaction parameters and inhibition by transfer ribonucleic acid.


Lipoprotein-polyanion-metal interactions.


Water balance and kidney function in some rodents native to Australia.


Newer insights into the role and modifications of olfaction in man through clinical studies.


165Er: an "ideal" radionuclide for imaging with pressurized multiwire proportional gamma cameras.


Interaction between adrenergic and cholinergic systems: presynaptic inhibitory effect of noradrenaline on acetylcholine release.


Interaction of estradiol and ACTH in the regulation of adrenal corticosterone production in the rat.


Interaction of staphylococcal protein A with virus-IgG complexes.


Accuracy of radionuclide cerebral angiograms in the detection of cerebral arteriovenous malformations.


The radiological diagnosis of congenital multicystic kidney 'Radiological Triad'.


A viral inhibitory substance in culture filtrates of Proteus mirabilis. 1. Inhibition of Sindbis virus plaque formation without a parallel antiviral action in fluid medium.


Lateral phase separations in binary lipid mixtures: correlation between spin label and freeze-fracture electron microscopic studies.


Programming of events in Epstein-Barr virus-activated cells induced by 5-iododeoxyuridine.


Membrane proteins of MSV-MLV: their role in virion-virion interactions in vitro.


Membrane fusion. Transfer of phospholipid molecules between phospholipid bilayer membranes.


Separation of the two non-identical subunits of lombricine kinase from Lumbricus terrestris muscle by chromatography on sepharose-mercurial. Isolation of the tryptic peptide containing its essential thiol group.


Alterations of murine immunologic responses after silica dust inhalation.


Alterations of surface properties of chick embryo fibroblasts infected with four Rous sarcoma viruses producing distinctive cell transformation.


Tuberculin testing in Macaca species: evaluation of two tuberculin diluents.


Disordered calcium metabolism during anticonvulsant treatment.


The reaction of alkylating agents with cyclic 3',5'-nucleotide phosphodiesterase.


Pancreatic islet cell carcinoma metastatic to the eyes.


Indirect hemagglutinating antibody response to Herpesvirus hominis types 1 and 2 in immunized laboratory animals and in natural infections of man. Indirect hemagglutinating (IHA) antibody responses to Herpesvirus hominis types 1 and 2 (HVH-1 and HVH-2) were compared to complement-fixing and neutralizing antibody responses in immunized laboratory animals (rabbits, guinea pigs, and hamsters) and in natural infections of man. With the immunized animals, type specificity was seen only in the IHA test and only with antisera produced in hamsters and in the rabbits immunized with HVH-2. In human nongenital infections (considered to be caused predominately by HVH-1), IHA and neutralizing antibodies developed at about the same rate and reached approximately the same levels for HVH-1 and HVH-2. IHA titers tended to be higher than neutralizing antibody titers for both virus types. In genital infections (considered to be caused predominately by HVH-2), there was a rapid IHA antibody response to HVH-2, and the early HVH-2 antibody demonstrable by IHA, but not by neutralization tests, was found to be immunoglobulin M in nature. In genital infections, IHA titers for HVH-2 were markedly higher than neutralization titers, but there was no pronounced difference in neutralizing the IHA antibody titers for HVH-1. Several patients with genital infections fialed to develop IHA antibody for HVH-1. The IHA test possessed no greater sensitivity than did complement fixation or neutralization tests for serodiagnosis of HVH infections. Despite the fact that a number of patients with genital infections produced IHA antibody only for HVH-2, the test was no more effective than the neutralization test in providing a type-specific serodiagnosis of infection, due largely to the fact that the rapid IHA antibody response to HVH-2 prevented demonstration of a further, significant antibody titer increase in a number of cases.


Altered amphibian cell morphology following treatment with polyene antibiotic and a mammalian RNA virus.


Altered protein metabolism in infection by the late tsB11 mutant of simian virus 40. The DNA of the temperature-sensitive mutant tsB11 is replicated at the same rate as the DNA of wild-type virus in infection at the restrictive temperature. The progeny mutant DNA cannot be distinguished from wild-type DNA by gel electrophoresis and is assembled into a nucleoprotein complex with the same velocity sedimentation characteristics as the wild-type complex. Analysis of in vivo protein synthesis by sodium dodecyl sulfate polyacrylamide gel electrophoresis and immunoprecipitation techniques demonstrated that the capsid components VP1, VP2, and VP3 of the mutant and wild-type virus are synthesized at a similar rate, but VP1 fails to accumulate within cells infected by tsB11. Furthermore, VP1 is located predominantly in the cytoplasmic rather than in the nuclear fraction of extracts from cells infected by the mutant. Immunofluorescent studies localized virion antigen within the nucleolus as well as the cytoplasm. The altered intracellular distribution and stability of VP1 suggest that it may be the mutant protein of tsB11. The synthesis of a 72,000 dalton protein is consistently induced in significant quantity in cells infected by tsB11 at the restrictive temperature. A protein of the same apparent molecular weight is present in smaller quantities in uninfected cells and is only slightly increased in quantity in cells infected by wild-type virus.


The regulation of cyclic guanosine monophosphate in rat cerebellum: possible involvement of putative amino acid neurotransmitters.


Age-related changes in vascular responsiveness to cyclic nucleotides and contractile agonists.


The relationship between plasma and tissue lipids in human atherosclerosis.


The relationship of total dust, free silica, and trace metal concentrations to the occupational respiratory disease of bituminous coal miners.


Low renin, "normal" aldosterone and hypertension: circadian rhythm of renin, aldosterone, cortisol and growth hormone.


Apparent correlation between adenosine 3':5' cyclic monophosphate levels and malignancy in somatic cell hybrids.


The reovirus murine models.

The reovirus murine models.


Fluorescent antibody study of a new bovine herpesvirus (strain DN-599).


The replication of papovavirus DNA.

The replication of papovavirus DNA.


The requirement for lipid fluidity in the formation and structure of lipoproteins: thermotropic analysis of apolipoprotein-alanine binding to dimyristoyl phosphatidylcholine.


Cigarette smoking and cholesterol atherosclerosis of rabbits.


Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. I. Effect of single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride on viral pathogenesis.


Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. II. Effect of multiple doses of polyriboinosinic-polyribocytidylic acid on viral pathogenesis.


Interferon-mediated increased lysis of L-cells by vesicular stomatitis virus.


Allergy involving the cranial nerves.

Allergy involving the cranial nerves.


Synergy of 9-beta-D-arabinofuranosyladenine and human interferon against Herpes simplex virus, type 1.


Distribution and persistence of avian encephalomyelitis viral antigens in internal organs of naturally infected chickens.


Arterial cannulation in awake restrained monkeys.


Distribution of calcium and magnesium in rat kidney homogenate fractions accompanying magnesium deficiency induced nephrocalcinosis.


Distribution of glutamate sensitivity on insect muscle fibres.


Distribution of sterols in the fungi. I. Fungal spores.


Distribution of WR-2721 in normal and malignant tissues of mice and rats bearing solid tumors: dependence on tumor type, drug dose and species.


Experimental herpes virus arthritis. Factors in chronicity.


Centrifugation.

Centrifugation.


Experimental investigations on the influence upon the chemical carcinogenesis. 1st Communication: Studies with ethylnitroso-urea.


Experimental Zieria arborescens (stinkwood) poisoning in rabbits.


Abnormal accumulation of sialoglycoproteins in a case of late infantile amaurotic idiocy.


Description by quasi elastic laser light scattering of a biological preparation: sarcoplasmic reticulum vesicles.


Abnormal brain scan in Paget's disease of bone-confusion with subdural hematoma.


Determination of "free" testosterone in plasma by GLC-63Ni ECD.


Oncornavirus directed tumor cell surface antigens detectable by humoral and cellular immunity.


Determination of the degree of in vivo tRNA aminoacylation in yeast cells.


Oestrogen receptors and antagonism of steroid hormone action.


Gastrointestinal fibroma. A clinicopathological study.


Control of phospholipid peroxidation and enzyme activity losses in mitochondria by antioxidants.


Control of uterine blood flow in pregnancy.


The role of calcium in insulin action. II. Effects of insulin and procaine hydrochloride on lipolysis.


The role of carboxyl, imidazole, and amino groups in inorganic pyrophosphatase of baker's yeast.


The role of choline in maintaining the fine structure of nerve terminals in the superior cervical ganglion of cat.


The role of cyclic nucleotides in the development and function of rat mammary tissue.


The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.


The role of cyclic AMP in neoplastic cell growth and regression. II. Growth arrest and glucose-6-phosphate dehydrogenase isozyme shift by dibutyryl cyclic AMP.


The role of the polyol pathway in methaemoglobin reduction in human red cells.


The role of platelet membrane phospholipids in the platelet release reaction. The structure and function of the platelet surface was probed by phospholipase C (Clostridium perfringens) which hydrolyzes membrane phospholipids, particularly phosphatidylcholine. Platelet phospholipids were susceptible to phospholipase C, and extent of hydrolysis was dependent on concentration of phospholipase C and Ca(++). Phospholipase C (0.15 U/ml) with Ca(++) (0.55 mM) hydrolyzed 15.6% phospholipids during 5 min. Phospholipase C released platelet serotonin (5HT), ADP, and platelet factor 4. Hydrolysis of 5% phospholipids resulted in release of 70% 5HT. Platelet 5HT release was rapid, occurring within 2 min. Phospholipase C (0.2 U/ml) with Ca(++) (0.55 mM) also released 10.35 nmol sotrage pool ADP/10(9) platelets and 63% platelet factor 4 during 3 min. Phospholipase C did not cause leakage of cytoplasmic metabolic pool ADP, since only 6.6% [(3)H]ADP was released. Ultrastructural analysis of phospholipase C-modified platelets showed that platelets were intact. After 2% phospholipid hydrolysis, centralization of granules and contraction of microtubules were evident. After 18% phospholipid hydrolysis, there were morphological indications of degranulation. Phospholipase C-induced phospholipid hydrolysis caused the release of ADP and 5HT since: (a) Phospholipase C purified by heating was shown to be free of protease and neuraminidase activity and capable of inducing the platelet release reaction. (b) Antitoxin (Cl. perfringens) neutralized phospholipase C-induced 5HT release which rules out a contaminant. (c) Phosphorylcholine, the hydrolysis product, did not induce platelet 5HT release. This study demonstrates that minimal hydrolysis of platelet phospholipids triggers the release reaction. Our hypothesis is that phospholipids, presumably phosphatidylcholine, are situated at or near active site or "receptor" on the platelet surface and function as the modulator for the release reaction.


The role of Clostridium perfringens in the growth response of chicks to dietary penicillin.


The role of viruses in the etiology of cancer and leukemia.


A serological study of antibody to Epstein-Barr virus in an Australian population.


Hyperostosis corticalis generalisata familiaris.


Chlorophyll b containing liposomes: effect of thermal transitions on catalytic and spectral properties.


Superoxide dismutases.

Superoxide dismutases.


Incorporation of lipid vesicles by mammalian cells provides a potential method for modifying cell behaviour.


Interrelationships among the levels of ATP, adenosine and cyclic AMP in incubated slices of guinea-pig cerebral cortex: effects of depolarizing agents, psychotropic drugs and metabolic inhibitors.


Interrelationships of pituitary and plasma corticotrophin and plasma corticosterone in adrenalectomized and stressed, adrenalectomized rats.


Occurrence of carcinoma of the bile ducts: a brief review.


Reversible inhibition of poliovirus RNA synthesis in vivo and in vitro by viral products. In poliovirus-infected HeLa-S3 cells, the protease inhibitors tolylsulfonyl-phenylalanyl chloromethyl ketone and iodoacetamide cause an accumulation of large precursor proteins, and they block viral RNA synthesis most probably via these products. Viral RNA polymerase activity can, however, be extracted by detergent containing buffer (Tris/Nonidet P-40, deoxycholate) from the inhibited cells. Only cytoplasmic extracts from infected cells treated with tolylsulfonyl-phenylalanyl chloromethyl ketone or iodoacetamide contain a protein which inhibits the in vitro polymerase reaction.


Revertants and secondary arom-2 mutants induced in non-complementing mutants in the arom gene cluster of Neurospora crassa. Extensive genetical and biochemical studies have been performed with revertants and secondary arom-2 mutants induced in two different primary non-complementing mutants which map within the arom gene cluster of Neurospora crassa. These studies indicate that mutant M54 but not M25 can revert by super-suppressor mutations in unlinked genes, thus confirming previous evidence that M54 contains a nonsense codon. At least three new super suppressors of M54 have been detected. All four super suppressors (including one previously detected) when combined with M54 result in high levels of all five of the arom enzymic activities in the form of arom multienzyme complexes very similar to (but not necessarily identical with) that in wild type (WT).-Evidence has also been obtained that the two non-complementing mutants can yield revertants which appear to result from true back mutations and produce arom aggregates essentially indistinguishable from that of WT. In addition, M25, but not M54, when plated on quinic acid yields revertants (secondary mutants) some of which are phenotypically indistinguishable from arom-2 primary mutants and others of which, although also mapping within the arom-2 gene, exhibit unusual properties. Genetic evidence indicates that the M25 secondary mutants are localized within the arom-2 gene, but that they arise from mutational events more complex than ones resulting in single base pair changes in the M25 codon.-The recovery of secondary arom-2 mutants as revertants of non-complementing arom mutants provides strong evidence, independent of earlier recombination data, that non-complementing arom mutants are located within the arom-2 structural gene of the arom gene cluster. In addition, the occurrence and characteristics of these secondary arom-2 mutants provide strong evidence, independent of the results with nonsense suppressors, that the arom gene cluster is transcribed, beginning with the arom-2 gene, as a single polycistronic messenger ribonucleic acid (mRNA) molecule which is subsequently translated into the arom multienzyme complex.


Hypertriglyceridemia and carbohydrate intolerance.


Restructuring medical education for management of the chronically ill aged.


Bilirubin UDP-glucosyl-and UDP-glucuronosyltransferase of rat liver. A comparative study of the effects of membrane perturbants in vitro and of chrysene administration in vivo.


Observations from longitudinal data on growth in stature and sitting height of children with Down's syndrome.


Observations on the resistance of Fpstein-Barr virus DNA synthesis to hydroxyurea.


A surveillance for Japanese encephalitis (JE) in pigs in southern Taiwan.


Observations on the action of type A botulinum toxin on frog neuromuscular junctions. 1. Progressive block of neuromuscular transmission in frog sartorius and gastrocnemius preparations by haemagglutinin-free crystalline Type A botulinum toxin (BTX) was investigated by in vitro application and by injection of the toxin into living animals.2. Neuromuscular block was characterized by (a) decline in amplitude of evoked twitch contractions, (b) decline in amplitudes of end-plate potentials (e.p.p.s) and (c) changes in statistical characteristics of spontaneous miniature end-plate potentials (m.e.p.p.s).3. Progress of the block was enhanced by nerve stimulation.4. A decrease in frequency to less than 0.1/sec and decreased average amplitudes of m.e.p.p.s preceded observable impairment of neuromuscular transmission. These changes occurred as early as 3 hr after injection of the toxin into dorsal lymph sacs.5. The amplitude distributions of m.e.p.p.s changed from a normal distribution to one that showed an increased skewness toward smaller amplitudes as the block progressed. These changes were first detectable as early as 75 min following addition of the toxin to the bath.6. At later stages of toxin action, e.p.p.s began to decrease in amplitude and eventually failed altogether. E.p.p.s showed a normal quantal variation at very early stages in the block in Mg(2+)-treated preparations. At later stages of the block, it was not possible to test the quantal make-up of the e.p.p.7. At all stages before complete failure it was possible to obtain normal or greater than normal degrees of synaptic facilitation with paired stimuli to the nerve. This aspect of the coupling of nerve terminal depolarization to transmitter release appears to be relatively unaffected by BTX.8. Electrical depolarization of nerve terminals in partially blocked preparations evoked a maintained discharge of m.e.p.p.s with an amplitude distribution similar to that of the spontaneous m.e.p.p.s; hyperpolarization of the terminals evokes a distinctly larger class of m.e.p.p.s. In fully blocked preparations, depolarization of the terminals does not evoke transmitter release whereas hyperpolarization continues to yield the larger class of m.e.p.p.s.9. It is proposed that the neuromuscular block caused by BTX is due to impairment of a process by which vesicles become charged with transmitter before release.


Mucus-producing adenocarcinoma of renal pelvis.


Air sampling of smallpox virus.

Air sampling of smallpox virus. Airborne smallpox virus has been recovered in an isolation hospital using an adhesive surface sampling technique in the presence of very low aerosol concentrations. Previous work in this field is reviewed. Successful recovery of airborne virus depends on sampling large volumes of air with a suitable sampler and thorough investigation of the whole sample taken for the presence of viable virus. More information on the characteristics and behaviour of airborne smallpox virus is needed in particular with regard to the future design and siting of smallpox isolation units.


Transcutaneous electrical stimulation for control of pain.


The search for a viral agent in Hodgkin's disease.


Viruses and brain tumors.

Viruses and brain tumors.


The significance of a palpable liver. A correlation of clinical and radioisotope studies.


The significance of cyclic 3'5-AMP for the Euler-Liljestrand mechanism.


A gosling disease in Viet-Nam.

A gosling disease in Viet-Nam.


Translation products of foot-and-mouth disease virus-infected baby hamster kidney cells.


Chiasma in the XY bivalent of the Chinese hamster.


Transmitter-dependent changes of equilibrium characteristics of catecholamine synaptosomes in sucrose density gradients.


Transport of sugars in tumor cell membranes.


A possible relation between human pathogenicity of smallpox vaccines and virus growth at elevated temperatures. Seven smallpox vaccines of known human pathogenicity were tested for their ability to produce pocks on the chick chorioallantois at 39.7 degrees C. Significant differences were found and the more pathogenic strains produced pocks with greater efficiency at 39.7 degrees C. than did strains of average or low pathogenicity.


A test of osteoblasts for hematopoietic competence.


The status of poliomyelitis in Venezuela.


The stereospecificity of the hydrogen transfer from (R)-carnitine to NAD, catalyzed by (R)-carnitine dehydrogenase from Pseudomonas aeruginosa.


The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.


The stimulatory effect of a serum factor on DNA and protein synthesis in hepatoma cells.


The stimulus-secretion coupling of glucose-induced insulin release. XVI. A glucose-like and calcium-independent effect of cyclic AMP.


Intestinal vasculitis in essential, mixed cryoglobulinemia.


The synthesis and biological activity of 25,26-dihydroxy-cholecalciferol, a polar metabolite of vitamin D3.


The state of laboratory automation.

The state of laboratory automation.


Short communications tissue culture of adult human adrenocortical cells.


Short rib-polydactyly syndromes and related conditions.


Ergot intoxication: historical review and description of unusual clinical manifestations. Clinical ergotism as seen today results almost exclusively from the excessive intake of ergotamine tartrate in the treatment of migraine headache. Although both gangrenous and convulsive symptoms are seen in naturally occurring ergotism resulting from the ingestion of fungus infected rye, only gangrenous ergotism has been reported following the excessive ingestion of ergotamine tartrate. The symptoms of both iatrogenic and naturally occurring ergotism appear to result from regional ischemia caused by ergot induced vasospasm. This report discribes experiences in the diagnosis and management of two patients with unusual manifestations of iatrogenic ergotism. One patient presented with ischemia of all extremities and bilateral foot drop probably due to ischemic damage to the common peroneal nerves, a finding not previously described in ergot intoxication. The foot drop totally resolved in several months following the discontinuation of ergot. A second patient presented with unilateral leg ischemia and transient monocular blindness, both of which resolved after discontinuation of ergot. Both patients displayed typical angiographic findings of ergotism. There is no convincing evidence that any treatment other than discontinuation of ergotamine is of benefit in the treatment of iatrogenic ergotism.


Prostaglandin E1 and fever.

Prostaglandin E1 and fever.


Spontaneous deaths in rabbits resulting from gastric trichobezoars.


Excitability changes in crayfish motor neurone terminals. 1. Changes in the post-activation excitability of crayfish motor nerve terminals were used to measure afterpotentials that might be related to facilitation of transmitter release.2. The refractory period is followed by a period of supernormal excitability in which the threshold of nerve terminals drops to about 70% of its pre-activation level at about 15 msec following an impulse. The threshold returns exponentially to its pre-activation level with a time constant of about 25 msec at 13 degrees C. Such a supernormal excitability is rarely seen in pre-terminal nerve branches or in the main axon.3. Following a brief high-frequency tetanus the peak of the supernormal excitability is greater than that following a single impulse. At low temperature this peak is reduced and delayed, and the decay rate of the supernormal excitability is prolonged with a Q(10) of about 2.5.4. Depolarization of nerve terminals decreases, and hyperpolarization increases, the magnitude of the post-activation supernormal excitability.5. The magnitude of the supernormal excitability depends on the external potassium concentration, but not on sodium. In low calcium the peak supernormal excitability is often reduced. High calcium concentration and manganese ions have no effect, but cobalt abolishes the supernormal excitability, and its effects are only slightly reversible. Both cobalt and manganese reversibly block neuromuscular transmission.6. Strophanthidin has no effect on the post-activation supernormal excitability, but proteolytic enzymes reduce or abolish it, and hyperosmotic solutions also affect it.7. It is suggested that the action potential is followed by a depolarizing afterpotential in nerve terminals which is caused by a transient increase in the potassium concentration around the terminals. There is no evidence that afterpotentials in nerve terminals are related to facilitation in any way.


Spontaneous recovery from severe rickets resembling pseudo-vitamin D deficiency rickets.


A mutant of Pseudomonas putida with altered regulation of the enzymes for degradation of phenol and cresols.


Adaptation in Rhodopseudomonas spheroides.


Adaptation of influenza virus to growth in cultured murine methylcholanthrene induced tumors.


A detector tube for the analysis of methyl isocyanate in air or nitrogen purge gas;.


Two temperature-induced changes in mitochondrial membranes detected by spin labelling and enzyme kinetics.


Hypothalamic nuclei of rats after head irradiation and adrenocortical hormone treatment.


Hypothalamus as an endocrine organ. II.

Hypothalamus as an endocrine organ. II.


A method for the detection of starch hydrolysis by bacteria.


A method for the determination of polyamines in cerebrospinal fluid.


Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.


Parathyroid hormone (PTH)-mediated rise in urinary cyclic AMP(UcAMP) during acute extracellular fluid (ECF) expansion natriuresis in man.


Hepatic amoebiasis. A study of 32 cases in the Western Cape.


Genetic analysis of mutations affecting growth of Saccharomyces cerevisiae at low temperature. A large number of genes control growth of the yeast Saccharomyces cerevisiae at low temperatures (< 10 degrees ). Approximately 47 percent of the mutants selected for inability to grow at 4-5 degrees C show increased sensitivity to cycloheximide. In 3 of 4 cases tested, supersensitivity to cycloheximide and inability to grow at the low temperature segregate together and thus appear to be effects of the same mutation. Since many cold-sensitive mutants of bacteria have been found to have altered ribosomes and since cycloheximide resistance in yeast can be caused by ribosomal changes, this suggests that the mutants having low-temperature-sensitive growth may be defective in ribosome-assembly processes at the low temperatures. Two of the lts loci, lts1 and lts3 have been located on chromosome VII and another two, lts4 and lts10 on chromosome IV. A mutation, cyh10, conferring cycloheximide resistance, but not cold sensitivity, has been located close to the centromere on chromosome II.


Kinetic approach to the development in beta-lactam antibiotics. I. Comparative stability of semisynthetic penicllins and 6-aminopenicillanic acid in aqueous solution.


Hepatic copper-and zinc-binding proteins in ruminants. 1. Distribution of Cu and Zn among soluble proteins of livers of varying Cu and Zn content.


Somatic cell hybrids between mouse peritoneal macrophages and SV40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carrying the SV40 genome. Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated that the hybridization of mouse nondividing cells with human cancer cells could permit the identification of the human "oncogenic" chromosome(s) present in human cancer cells, since such chromosome(s) should be retained by the totality of the mouse-human hybrid cells.


Genetic manipulation of an abnormal jump response in Drosophila. The hyperkinetic mutants, Hk(1) and Hk(2), jump and fall over when an object moves near them. This behavior, the kinetogenic response, has been measured by the experimenter moving his hand above a vial containing a single fly and scoring the number of positive responses in fifty trials. The response is higher in Hk(1) than in Hk(2) and has remained so over a period of several years and in different genetic backgrounds. The Hk(1)/Hk(2) heterozygote also responds to movements, establishing the allelism of the two mutants.-When Sh(5), a shaker mutant at another locus on the X chromosome, is introduced into the same chromosome as Hk(1) or Hk(2), the response is reduced in proportion to the number of Sh(5) mutant genes added.-When Hk(1) or Hk(2) is heterozygous with a deficiency for the hyperkinetic region of the X chromosome, the expression is more abnormal than the respective Hk(1) or Hk(2) homozygote. This shows that the mutant genes are producing an altered gene product, or less of the normal, since one mutant gene by itself has a more abnormal expression than two. A tentative explanation has been offered for the observed mutant behaviors.


Kinetics of allosteric enzymes.

Kinetics of allosteric enzymes.


Kinetic regulation of adenylate kinases from muscle, liver, and hepatoma.


Kinetics of ligand-binding and oxidation-reduction reactions of cytochrome c from horse heart and Candida krusei.


Kinetics of pyrophosphate-ATP exchange catalysed by L-tryptophan: tRNA ligase from Escherichia coli.


Deletion analysis of two nonessential regions of the T4 genome.


Function and structure of plasma lipoproteins.


Rotational and translational diffusion in membranes.


Functional correlates of dopamine neurotransmission.


Functional development of the autonomic innervation of the human fetal heart.


Fractionation and molecular weight determination of deoxyribonucleic acid fragments using agarose column chromatography.


Fractionation of islet tissue in processing proinsulin to insulin.


Relationship between SMON virus and avian infectious laryngotracheitis virus.


Quantitation of endogenous C-type virion production in several murine cell lines. Quantitation by enumeration of virion particles, measurement of absorbancy at 260 nm, and densitometry on sodium dodecyl sulfate-polyacrylamide gels has shown that mouse L-M cells yielded 7- to 10-fold less endogenous C-type virions than the parental lines, L or L929. The previously noted stimulation of L-M cell virion production by a concomitant 10% increase in fetal calf serum concentration (D. A. Kindig, R. Karp, and W. H. Kirsten, 1968), was not observed.


Hepatitis and brain lesions due to mouse hepatitis virus accompanied by wasting in nude mice.


Quantitative genetic studies of the human plasma Lp(a) lipoprotein.


Hepatitis-associated antigen, cirrhosis and hepatoma in Rhodesia.


Hepatitis following actinomycin D and irradiation.


Hepatitis A: in vitro isolation of an agent with unusual growth requirements from a clinical case occurring in Costa Rica.


Relative dependence on intracellular cyclic adenosine-3',5'-monophosphate levels of catabolite repressible proteins in Escherichia coli.


Positive mediastinoscopy. An ominous finding.


Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol.


Reactivity of chick embryo heart to cholinergic agonists during ontogenesis: decline in desensitization at the onset of cholinergic transmission.


Symptomatic porphyria. I. The pathology of the liver in human symptomatic porphyria.


Symptomatic porphyria. II. Hepatic changes with hexachlorobenzene.


Somatostatin inhibition of rat growth hormone release in vitro in the presence of BaCl2 or 3-isobutyl-1-methylxanthine.


Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain.


Spectral resolution of four cytochrome b components in mitochondria.


Clostridium perfringens in the environment. Clostridium perfringens was isolated from samples collected in Puget Sound in the state of Washington and areas considered as possible sources of these organisms to Puget Sound. The distribution of C. perfringens in the total Clostridium population was determined for fish gut contents and sediments collected in highly polluted and less polluted areas, sewage samples, freshwater sediments, and soils. The greatest numbers of C. perfringens were obtained from marine sediments collected near the sewage outfall at West Point. Fewer isolates were made from fish collected from less polluted stations, although the number of C. perfringens remained high in sediments from other Puget Sound stations. The proportion of C. perfringens in the total Clostridium populations varied between 56 and 71% for sewage samples and only 0.4 to 4.1% for freshwater sediments and soil samples. Only 25 C. perfringens isolates out of 137 from fish guts, or 18%, were identifiable serologically and these fell into 12 groups. C. perfringens were fed to fish and the fish were sacrificed after varying lengths of time. The number of C. perfringens increased slightly in the gut during the first 24 h and then the numbers decreased rapidly for the next 120 h.


Electron microscopic demonstration of insulin receptors on adipocyte plasma membranes utilizing a ferritin-insulin conjugate.


Electron microscopic observations on infectious bovine rhinotracheitis virus in bovine fetal tracheal organ cultures.


Electron spin resonance of manganese(II)-substituted zinc(II) metalloenzymes.


Electron microscopy of single-stranded RNA from vesicular stomatitis virus.


Electrical activity of gastrointestinal smooth muscle.


Electron spin resonance spectra from whole blood of cancer patients.


Electron-spin resonance of an X-irradiated single crystal of N-acetyl-DL-valine.


Electron-paramagnetic-resonance studies on cobalt(II) carbonic anhydrase. Low-spin cyanide complexes. The low-spin cyanide complexes of three Co(II) carbonic anhydrases were investigated by electron paramagnetic resonance (e.p.r.) at 9 and 35GHz. Well-defined and closely axial spectra were obtained only in the absence of oxygen. Several mole equivalents of cyanide were required for complete formation of the complexes in frozen solution, although large excesses caused abstraction of the cobalt. Experiments with [(13)C]cyanide showed that the low-spin complexes contained two CN(-) groups in an environment similar to that of the in-plane ligands in [Co(CN)(5)](3-). A combined e.p.r. and spectrophotometric titration confirmed the presence of two CN(-) ligands. A 5-co-ordinate square pyramidal structure involving three protein ligands was proposed. The dicyanide complex could be oxygenated reversibly, producing a characteristic new e.p.r. spectrum. The O(2) molecule was thought to occupy the remaining octahedral metal site in a formally Co(III) species. The optical spectrum of the dicyanide lacked the prominent d-d bands of the high-spin monocyanide. Both e.p.r. and optical data indicated that the low-spin complex was formed much more fully in frozen solution than at room temperature. Differences in behaviour between the high- and low-activity enzymes suggested some variation in conformational flexibility at the metal binding site.


The trophic responses of cultured adrenocortical cells to ACTH.


Electrophoretic polymorphism of adenylate kinase in human jejunum.


An attempt to identify putative neurotransmitter substance released from the non-adrenergic inhibitory fibers in the vagal supply to the guinea-pig stomach.


An attempt to localize cyclic phosphodiesterase at adrenergic nerve endings.


Denaturation of the normal and abnormal hemoglobin molecule.


Dibutyryl cyclic adenosine 3',5-monophosphate and brain lipid metabolism.


Evaluation of serum dopamine-beta-hydroxylase activity as an index of sympathetic nervous activity in man.


Evaluation of a plaque assay for the maedi-progressive pneumonia-visna viruses. A simple and direct plaque assay for maedi virus, two strains of progressive pneumonia virus, and two strains of visna virus has been developed and evaluated. The technique allows the plaques formed by these viruses to be localized without disturbing the host-cell substrate of sheep choroid plexus cells or the gelled maintenance medium over the host-cell monolayer. Diethylaminoethyl-dextran supplementation of the medium used to overlay strain K796 visna virus-infected cultures decreases the time required for maximum plaque development from 12 to 10 days, enhances the contrast of the plaques, increases the titer of plaque-forming units, and permits a plaque size heterogeneity to be realized. Both large and small plaques occur in cultures infected with the visna viruses, one strain of progressive pneumonia virus, or maedi virus. In contrast, the plaques observed in cultures infected with the second strain of progressive pneumonia virus are relatively homogeneous in size.


Production and localization of the secretory component in tumours of the exocrine glands.


Production of sindbis, influenza, and vesicular stomatitis viruses in chicken embryo and rat embryo cell suspensions.


A study of the relationships between carbon tetrachloride-induced lipid peroxidation and liver damage in rats pretreated with vitamin E.


A study of urolithiasis in grazing ruminants in South Australia.


A study of tumors of the parapharyngeal space.


Tissue sensitivity to drugs in disease states.


Tissue androgens and androphilic proteins in rat epididymis during sexual development.


Influence of adrenal steroids on liver enzymes of neonatally castrated rats.


Influence of corticotrophic and corticosteroid hormones on the output of cells from the popliteal lymph node of the sheep.


Influence of immunosuppressive drugs on replication of Col MM virus and productive of interferon in vivo.


Influence of membrane phosphatidylinositol content on the activity of bovine brain phospholipid transfer protein.


Influence of the socio-economic level on the conception rate during lactation.


Influence of the hormonal forms of ACTH on the pattern of corticosteroid secretion.


Cellular and humoral immune interactions during neoplastic development.


Granular cells and granular cell lesions.


Cellular distribution of nicotinamide adenine dinucleotide glycohydrolase in the central nervous system.


Stimulation of hepatic triglyceride synthesis and secretion by clofibrate.


Stimulation of mitochondrial DNA synthesis as an early function of herpes simplex virus.


Stimulation of thymidine kinase induction by polyoma virus in cells "prelabeled" with 5-bromo-2'-deoxyuridine.


Stimulation of ribosomal and DNA-like RNA synthesis by alpha-methyltryptophan.


Stimulation of the posterior columns of the spinal cord for pain control: indications, technique, and results.


The ultrastructure of cytoplasmic inclusions in circulating lymphocytes in canine distemper.


The ultrastructure of neuroblastoma glioma somatic cell hybrids. Expression of neuronal characteristics stimulated by dibutyryl adenosine 3',5' cyclic monophosphate.


Conjunctival bacterial flora of the clinically normal New Zealand white rabbit.


Failure of cytochrome C to cure experimental Amanita phalloides poisoning.


Failure to demonstrate serotonergic neurons in the myenteric plexus of the rat.


Tumours and dysplasias of the mammary gland. As mammary tumours occur frequently in the dog and cat but rarely in other domestic animals, only the tumours of these two species are classified. The epithelial tumours are termed "complex" when they consist of cells resembling both secretory and myoepithelial cells: these tumours are biologically less malignant than tumours of the "simple" type in which only one of these kinds of cell is present. The carcinomas are subdivided into adenocarcinoma, solid carcinoma, spindle cell carcinoma, anaplastic carcinoma, squamous cell carcinoma, and mucinous carcinoma. The term "carcinosarcoma or malignant mixed tumour" was used only when there were cells morphologically resembling not only one or both of the epithelial components but also connective tissue cells with their products of differentiation. The benign tumours are classed as adenoma, papilloma, fibroadenoma, or benign soft tissue tumour. The dysplasias are described under the following headings: cyst, adenosis, regular typical epithelial proliferation in ducts and lobules (epitheliosis), duct ectasia, fibrosclerosis, and lobular hyperplasia.


Tumours of the lung.

Tumours of the lung. Lung tumours are not common in domestic animals; there has not been the increase in epidermoid carcinomas and anaplastic small-cell carcinomas that has occurred in man this century. Adenocarcinoma is the most common type in animals. The biological behaviour of each type of tumour in animals seems to be much the same as in man. The tumours are described histologically, the main categories being: epidermoid carcinoma, anaplastic carcinoma, adenocarcinoma, combined epidermoid and adenocarcinoma, carcinoid tumours, bronchial gland tumours, benign tumours, and sarcomas.


Tumours of the nervous system.

Tumours of the nervous system. Tumours of the nervous system of animals are not as rare as has been commonly believed. In dogs, especially the brachycephalic breeds, these tumours occur as frequently as in man. The tumours are grouped according to tissue of origin as follows: nerve cells, neuroepithelium, glia, peripheral nerves and nerve sheaths, meninges and vessels, the pineal and pituitary glands, and the craniopharyngeal duct. Tumours of the glia are relatively common and are divided into the following types: astrocytoma, oligodendroglioma, glioblastoma, spongioblastoma, medulloblastoma, and unclassified gliomas.


Tumours of the soft (mesenchymal) tissues. This is a classification of tumours of fibrous tissue, fat, muscle, blood and lymph vessels, and mast cells, irrespective of the region of the body in which they arise. Tumours of fibrous tissue are divided into fibroma, fibrosarcoma (including "canine haemangiopericytoma"), other sarcomas, equine sarcoid, and various tumour-like lesions. The histological appearance of the tumours is described and illustrated with photographs.


Tumours of the urinary bladder.

Tumours of the urinary bladder. Tumours of the urinary bladder are uncommon in all domestic animals except cattle in certain regions. Where cattle eat bracken (Pteridium aquilinum) there is a high incidence of these tumours. Epithelial tumours are the most frequently encountered neoplasms in cattle and in dogs-the two species most studied. They are described under the following names: papilloma, adenoma, transitional cell carcinoma (with variants), squamous cell carcinoma, adenocarcinoma, and undifferentiated carcinoma.


Status of the endogenous avian leukosis virus in resistant cells from a producing line.


The use of continuous preparative free-flow electrophoresis for dissociating cell fractions and isolation of membranous components.


The use of non-professional change agents in an institution.


The use of oestrogen-progestogen preparations in the treatment of hirsutism in the female.


The use of BSVR-SrCr mice for detection of murine strains of toxigenic Escherichia coli.


Disruption of drinking to intracranial angiotensin by a lateral hypothalamic lesion.


The use of CI 744 as an anesthetic for laboratory animals.


Computerized primate information retrieval system (PIRS).


The validity of comparing the measurements of angiotensin I generated in human plasma by radioimmunoassay and bioassay.


Salivary gland scintiphotography.

Salivary gland scintiphotography.


Renovascular hypertension. A clinical and laboratory study.


Pryuvate as substrate in the determination of serum lactate dehydrogenase isoenzyme activity.


The vasopressin-sensitive adenylate cyclase of the rat kidney. Effect of adrenalectomy and corticosteroids on hormonal receptor-enzyme coupling.


Pyruvate carboxylase from chicken liver. Magnetic resonance studies of the effect of substrates and inhibitors on the environment of the bound manganese.


Activation and dissociation of adenosine 3'-5'-monophosphate-dependent and guanosine 3'-5'-monophosphate-dependent protein kinases by various cyclic nucleotide analogs.


Active transport of exogenous S-adenosylmethionine and related compounds into cells and vacuoles of Saccharomyces cerevisiae. Saccharomyces cerevisiae 4094-B (alpha, ade-2, ura-1) in potassium phosphate buffer with glucose under aerobic conditions took up (-)S-adenosyl-l-methionine from the medium in sufficient quantity to permit the demonstration of its accumulation in the vacuole by ultraviolet micrography. The same result was obtained with (+/-)S-adenosyl-l-methionine, (+/-)S-adenosyl-d-methionine, and (-)S-adenosyl-l-ethionine. The rate of uptake was slow with (-)S-adenosyl-S(n-propyl)-l-homocysteine and S-adenosyl-d-homocysteine. S-Adenosyl-l-homocysteine was assimilated rapidly, but intracellular degradation precluded accumulation and ultraviolet micrographic studies. The uptake of 5'-methyl-, 5'-ethyl-, 5'-n-propylthioadenosine, and 5'-dimethylsulfonium adenosine was minimal.


Activation of lipoprotein lipase in vitro by unsaturated phospholipids.


A novel respiration-deficient mutant of Saccharomyces cerevisiae. I. Preliminary characterization of phenotype and mitochondrial inheritance.


Recovery of herpes simplex virus from human sacral ganglions.


Recovery of adenoviruses and slow herpesviruses from horses having respiratory tract infection.


Recovery of DNA-dependent RNA polymerase activities from L cells after mengovirus infection.


Synovial sarcoma arising from the lower end of the femur.


Synovial sarcoma of the head and neck.

Synovial sarcoma of the head and neck.


Synovial sarcoma of the tongue, report of a case.


Behavioral manifestations of competition of retinal endings for sites in doubly innervated frog optic tectum.


Behavioral effects of direct- and indirect-acting dopaminergic agonists.


Behavioral modulation of the cardiovascular effects of l-norepinephrine in the squirrel monkey.


Behaviour of flagella isolated from Crithidia oncopelti.


Activity of reduced ubiquinone: cytochrome c oxidoreductase with various ubiquinol-isoprenologues as substrate and corresponding inhibitory effect of antimycin in yeast.


A new approach for selecting patients with metastatic breast cancer for hypophysectomy.


Behaviour of rat-liver mitochondria during centrifugation in a sucrose gradient.


A new class of lipopolysaccharide from Thermoplasma acidophilum.


A new fluorimetric procedure for the detection and quantitation of organic compounds in thin-layer chromatography.


A low molecular weight ruthenium complex inhibitory to mitochondrial Ca2+ transport.


A new, sensitive detector for liquid chromatography: the spray impact detector.


An examination of the metabolism of thiamin by rat liver alcohol dehydrogenase.


Autoxidation as a cause of antibacterial activity in unsaturated fatty acids.


An extracellular nuclease from suspension cultures of tobacco.


On extraction of acyl and alkyl dihydroxyacetone phosphate from incubation mixtures.


Fully automated, all-enzymatic triglyceride method adapted to the GEMSAEC centrifugal analyzer, with use of an aqueous triolein standard.


Study of nucleolar vacuolation and RNA synthesis in embryonic root cells of Zea mays.


Epoxy-fiberglass adsorbent for concentrating viruses from large volumes of potable water. A simple and compact virus-adsorbing unit for efficiently concentrating human enteric viruses from 100 gallons (about 380 liters) or more of potable water is described.


Prolyl hydroxylase.

Prolyl hydroxylase.


Adenylate cyclase activity in rat adipocyte plasma membranes after adrenalectomy and administration of cortisone acetate. Effects of calcium ions and hormonal stimulations.


Acetylglutamate kinase: a feedback-sensitive enzyme of arginine biosynthesis in Neurospora.


Biosynthesis of collagen and elastin by chick embryo skin during maturation.


Biosynthesis of oligogalactosyl side chains of the cell envelope glycoprotein of Cryptococcus laurentii.


Analysis of penicillic acid by gas-liquid chromatography.


The Klippel-Trenaunay-Weber syndrome.

The Klippel-Trenaunay-Weber syndrome.