Effect of spironolactone and ethylestrenol on benzo(a)pyrene hydroxylase (EC 1.14.1.1) and other chemical constituents of hepatic microsomes.


Delayed after effects of medically induced abortion.


Age-correlated variations of rat liver serine dehydratase and tyrosine aminotransferase activities--a comparative analysis.


Multiple endocrine adenomatosis.

Multiple endocrine adenomatosis.


Effects of practolol, a new adrenergic receptor blocking agent on cardiovascular responses.


Topical mosquito repellents. IV. Alicyclic, bicyclic, and unsaturated acetals, aminoacetals, and carboxamide acetals.


Eosinophilic cystitis: observations on etiology.


Rcn Congress Report. Representative Body Meeting.


Urogenital abnormalities produced in rat fetuses with chlorcyclizine.


Transmission of hog cholera virus by horseflies (Tabanidae: Diptera).


Experience with a surgeon's assistant in a community practice.


Enhancement by carbon tetrachloride treatment of hepatic tyrosine amino-transferase induction in the presence of net polyribosome breakdown in the rat.


The maintenance of maldescended testicles within the scrotum using a dartos pouch.


The effects in vivo of L- and D-para-chlorophenylalanine on the aromatic hydroxylating activity of rat liver.


Health manpower.

Health manpower.


Long-term care.

Long-term care.


AAMI-FDA 1972 National Conference on Medical Device Standards.


Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity. A 52 yr old Caucasian female (F. E.) had hemolytic anemia, a leukemoid reaction, and fatal sepsis due to Escherichia coli. Her leukocytes ingested bacteria normally but did not kill catalase positive Staphylococcus aureus, Escherichia coli, and Serratia marcescens. An H(2)O(2)-producing bacterium, Streptococcus faecalis, was killed normally. Granule myeloperoxidase, acid and alkaline phosphatase, and beta glucuronidase activities were normal, and these enzymes shifted normally to the phagocyte vacuole (light and electron microscopy). Intravacuolar reduction of nitroblue tetrazolium did not occur. Moreover, only minimal quantities of H(2)O(2) were generated, and the hexose monophosphate shunt (HMPS) was not stimulated during phagocytosis. These observations suggested the diagnosis of chronic granulomatous disease. However, in contrast to control and chronic granulomatous disease leukocytes, glucose-6-phosphate dehydrogenase activity was completely absent in F. E. leukocytes whereas NADH oxidase and NADPH oxidase activities were both normal. Unlike chronic granulomatous disease, methylene blue did not stimulate the hexose monophosphate shunt in F. E. cells. Thus, F. E. and chronic granulomatous disease leukocytes appear to share certain metabolic and bactericidal defects, but the metabolic basis of the abnormality differs. Chronic granulomatous disease cells lack oxidase activity which produces H(2)O(2); F. E. cells had normal levels of oxidase activity but failed to produce NADPH due to complete glucose-6-phosphate dehydrogenase deficiency. These data indicate that a complete absence of leukocyte glucose-6-phosphate dehydrogenase with defective hexose monophosphate shunt activity is associated with low H(2)O(2) production and inadequate bactericidal activity, and further suggest an important role for NADPH in the production of H(2)O(2) in human granulocytes.


Pharyngeal pneumococcal acquisitions in "normal" families: a longitudinal study.


Are doctors always necessary? A review of the need for the medical assistant in developing countries.


NADPH-dependent cleavage of carbamates.

NADPH-dependent cleavage of carbamates.


Lymphoid infiltration in the F 1  hybrid liver as a thymus cell function.


The effect of lymphocytes and serum from tolerant rats on the graft-versus-host activity of normal lymphocytes.


"Slaughter testicle" in the cryptorchid pig.


Oestrogen biosynthesis by the rat ovary in early pregnancy.


A look at the physician's assistant.

A look at the physician's assistant.


The Eight ANA Nursing Research Conference.


Reductive pathways of progesterone metabolism in the rat ovary.


Sepiapterin reductase from horse liver: purification and properties of the enzyme.


Further studies of electron transport components in a series of Morris hepatoma-bearing rats. Microsomal electron transport components (NADPH oxidase, NADPH-ferricyanide reductase, cytochromes P-450 and b(5)) have been studied in Buffalostrain rat liver and in a series of Morris hepatomata (9618A-2, 7800, 7795 and 7787). Normal liver values differed significantly from those measured in livers of tumourbearing animals. In all hepatomata per se, very low levels were found.


The in vitro reduction of aflatoxins B 1  and B 2  by soluble avian liver enzymes.


Electron microscope observations on the development of Breinlia sergenti in mosquito.


Further testing of fenthion for prophylactic effects against the developing stages of Dirofilaria immitis.


Mosquitoes of the Chagos Archipelago, Indian Ocean.


Structural and functional changes of isolated rat diaphragm after treatment with caffeine together with local anaesthetics and beta-receptor blockers.


Properties and kinetics of biliverdin reductase.


3 -Hydroxy steroid dehydrogenase activity in the mitochondria of rat adrenal homogenates. The activity of 3beta-hydroxy steroid dehydrogenase (EC 1.1.1.51) in the mitochondrial fraction of rat adrenal homogenates was approx. 31% of the total activity recovered after differential centrifugation and washing of the particulate fractions. Some 45% of the total activity was found in the microsomal fraction. The activity was assayed by a radioisotopic method devised in this laboratory for the purpose of studying small quantities of tissue and cell fractions. Satisfactory separation of the two fractions was demonstrated by electron microscopy of the pellets and by comparative recoveries of RNA, steroid 21-hydroxylase and cytochrome c oxidase in the various compartments. Analyses of the kinetics of the enzyme activity in the two fractions revealed no significant differences in apparent K(m) for pregnenolone, dehydroepiandrosterone or NAD(+), but demonstrated a distinct difference in the K(m) for NADP(+). pH optima and susceptibility to cyanoketone inhibition were similar in both fractions.


Organisation in the school dental service. II. Epidemiology.


Possible heterogeneity of the distribution of lysosomal marker enzymes among "lysosomal particles" of rat liver.


Resistance of noradrenaline in blood vessels to depletion by 6-hydroxydopamine or immunosympathectomy. 1. The degree of the decrease in the noradrenaline concentrations caused by 6-hydroxydopamine or immunosympathectomy was different in different areas of the cardiovascular system.2. In rats or guinea-pigs 6-hydroxydopamine depleted the noradrenaline content of the heart by 90%, of the mesenteric vein by 80% and of the mesenteric artery and aorta by 30-60%. Immunosympathectomy elicited a 70% reduction in the cardiac noradrenaline but only a 50% reduction in the noradrenaline of the blood vessels of the rat.3. The tyrosine hydroxylase activity of the heart, blood vessels, or adrenal glands was not significantly altered 2 weeks after 6-hydroxydopamine. Nor was the monoamine oxidase activity in heart or blood vessels changed.4. The inconsistent ability of both 6-hydroxydopamine and immunosympathectomy to abolish experimental hypertension may be due to the partial persistence of noradrenaline and functional sympathetic nervous system activity in the blood vessels.


Effect of -adrenoceptor blocking agents on poststimulatory atrial flutter in the dog, with observations on the participation of adrenergic mechanisms in this experimental arrhythmia. 1. Four beta-adrenoceptor antagonists, viz. (+/-) propranolol (0.5 mg/kg), (-) alprenolol (0.25 mg/kg), practolol (5 mg/kg) and USVC 6524 (20 mug/kg), were tested for their effects on atrial flutter produced by electrical stimulation of the right atrium around the crushed inter-venae-caval bridge in anaesthetized dogs.2. All the drugs reduced atrial and ventricular rates; this was followed by the abrupt termination of flutter and restoration to normal sinus rhythm.3. Since all the drugs (including practolol, which is devoid of local anaesthetic activity) were given in doses just sufficient to block beta-adrenoceptors, it indicated that beta-adrenoceptor blockade was responsible for their antiarrhythmic property in this test procedure.4. Further evidences in support of participation of the sympathetic nervous system in poststimulatory flutter were: (i) flutter could not be produced in nine out of ten dogs whose catecholamine stores were depleted by pretreatment with reserpine; (ii) infusion of adrenaline in these animals resulted in the production of flutter; (iii) duration of flutter after termination of exposure to adrenaline was a few minutes, which is similar to the brief time previously reported to be taken for the disappearance of catecholamines from the hearts of reserpinized animals.5. The clinical significance of the above findings is discussed.


Abolition of the nerve-induced responses of the isolated vas deferens of the young rat by agents blocking  -adrenoceptors. The mechanical responses of isolated fieldstimulated vasa deferentia from rats 3-10 days old were abolished by low doses of drugs blocking alpha-adrenoceptors. In preparations from older animals this effect was absent or there was a potentiation of the responses. The effect of atropine also changed during postnatal development. In the early period a moderate (10-40%) decline of the nerve-induced responses was generally observed, but later even high concentrations of atropine were without effect.


Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901). 1. Indoramin is a competitive alpha-adrenoceptor blocking agent on the guinea-pig isolated vas deferens and aortic strip; the pA(2) value on the aorta is 7.4.2. Indoramin is devoid of beta-adrenoceptor blocking activity on the guinea-pig isolated trachea (10(-4)M) and the Langendorff preparation of the rabbit heart (10(-6)M). It also has no adrenergic neurone blocking action on the Finkleman preparation of the rabbit small intestine (10(-5)M).3. On the Langendorff preparation of the rabbit isolated heart, indoramin (above 10(-6)M) has cardio-inhibitory properties similar to those of propranolol.4. On the guinea-pig isolated ileum (10(-5)M) and trachea (10(-6)M), indoramin is devoid of anticholinergic activity, but has a potent antihistamine action which satisfies the criteria for competitive antagonism; the pA(2) value for this antagonism on the ileum is 8.2.5. Indoramin antagonizes 5-hydroxytryptamine on the rat isolated fundus and ileum; the pA(2) value for the antagonism on the ileum is 6.0.


1 -tetrahydrocannabinolic acid, an important component in the evaluation of cannabis products.


The influence of the moisture content of the fibrous support of a nasal inhaler upon the concentration of drug in the air stream.


Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man. 1. N-Demethylation of pethidine was studied in microsomal suspensions from unstarved male rat liver and the N-demethylase identified as belonging to the class of hepatic microsomal mixed function oxidases.2. A study of the structure/action relationships of compounds inhibiting pethidine N-demethylase revealed that hydrazine derivatives including phenylhydrazine, methylphenylhydrazine and mebanazine were all potent competitive inhibitors.3. Pethidine N-demethylase was only slightly inhibited by histamine and amphetamine but not by adrenaline and ephedrine nor by several miscellaneous compounds including piperidine, N-ethylpiperidine, N-methylpiperidine, N-methylammonium, hydrallazine or pethidinic acid.4. Several psychotropic drugs were all found to be potent competitive inhibitors of pethidine N-demethylase. These included monoaminoxidase inhibitors (the most active being nialamide and phenoxypropazine [K(i)=0.01 mM]; the least active iproniazid [K(i)=1.05 mM]); the tranquillizers promazine, propiomazine and chlorpromazine and tricyclic antidepressants (opipramol [K(i)=0.01 mM], imipramine [K(i)=0.03 mM], desipramine [K(i)=0.03 mM] and amitryptyline [K(i)=0.03 mM]). Hydrocortisone [K(i)=0.3 mM], prednisolone [2.8 mM] and nalorphine [0.07 mM] were also inhibitors, whilst SKF 525A was the most active of all [K(i)=0.002 mM].5. These results are discussed in relation to the clinically observed drug interactions which may occur between monoamineoxidase inhibitors and pethidine. It is concluded that since many different groups of drugs, including monoamineoxidase inhibitors, tranquillizers, tricyclic antidepressants, steroids, nalorphine, SKF 525A and barbiturates compete for cytochrome P(450) reductase, it is possible that this mechanism may account, at least in part, for the observed interactions of these various drugs in man.


The biliary excretion of tartrazine. Sex differences in the rat and species differences in the rat, guinea-pig and rabbit.


Synthesis and pharmacology of 1-(2-thioxopyrrolidino)-4-pyrrolidino-2-butyne, the thiolactam analogue of oxotremorine.


Pharmacodynamic effects of dehydroemetine.


The effect of morphine pretreatment on the sensitivity of mouse and guinea-pig ileum to acetylcholine and to morphine.


The actions of histamine and prostaglandins F 2   and E 2  on pulmonary vascular resistance of the lung of the guinea-pig.


Brain concentrations of lorazepam and oxazepam at equal degree of anticonvulsant activity.


Effect of amphetamines on tryptophan concentrations in mice and rats.


5-Hydroxytryptamine antagonists related to cinanserin in human isolated smooth muscle.


Effect of drugs that modify 3',5'-AMP concentrations on morphine analgesia.


Ulceration of the colon in rabbits fed sulphated amylopectin.


On the histamine-binding property of human serum.


Anti-acetylcholine, and adrenaline-potentiating activity of oxotremorine on guinea-pig isolated vas deferens.


An adrenoceptor proteolipid isolated from the spleen capsule.


The effect of (--)-noradrenaline on artificial lipidic membranes containing a proteolipid with adrenoceptor properties.


Inhibition of catechol-O-methyl transferase by L-dopa and decarboxylase inhibitors.


Effect of reserpine on the transport of 5-hydroxytryptamine to the rat brain.


Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side-chain.


The conformation of 5-hydroxytryptamine in solution.


Centrally mediated contraction of the lower eyelid elicited by anticholinesterases in anaesthetized rats.


Species difference in the lowering of brain 5-hydroxytryptamine by m-chloroamphetamine.


A modified silver clip used in the induction of renal hypertension in the rat.


Opening remarks.

Opening remarks.


Non-specific reactions of the glutathione oxidant "diamide" with mammalian cells.


Resistance to  -adrenoceptor stimulants.

Resistance to  -adrenoceptor stimulants.


Risk with  -blocking in bronchial asthma.


Interacting influences of embryonic & neoplastic systems. I. Responses in chick embryo to the grafted mouse mammary adenocarcinoma.


Mechanism of mercuric chloride resistance in microorganisms. II. NADPH-dependent reduction of mercuric chloride and vaporization of mercury from mercuric chloride by a multiple drug resistant strain of Escherichia coli.


Electron transport systems of lung microsomes and their physiological functions. I. Intracellular distribution of oxidative enzymes in lung cells.


Inactivation in vivo of glutamine synthetase and NAD-specific glutamate dehydrogenase: its role in the regulation of glutamine synthesis in yeasts.


Pyruvic acid and formic acid metabolism in Sarcina ventriculi and the role of ferredoxin.


Hastings fluoridation project V1--Dental effects between 1954 and 1970.


Cardiovascular effects of cnidarian toxins: a comparison of toxins extracted from Chiropsalmus quadrigatus and Chironex fleckeri.


Histamine-induced bronchospasm in unanaesthetized guinea-pigs. II. A comparison of the bronchospasmolytic agents terbutaline, orciprenaline and isoprenaline.


Evaluation of slow-releasing diphenylpyraline in chronic urticaria and various kinds of dermatites.


Reaction mechanism of D-amino acid oxidase.


The non-enzymic oxidation of NADH by nitrosobenzene.


Evidence for the existence of an active form of tyrosine transaminase of very low molecular weight.


Further observations on whether host immunodepression is associated with tumour growth in mice. In order to investigate whether the presence of a tumour was associated with immunodepression in the host, spleen cells from parent line animals with tumours were injected intravenously into F(1) hybrids, half of which carried the same tumour. Further groups of F(1) hybrid with and without the tumour received spleen cells from non-tumour bearing parent line animals. The G.V.H. reactions induced in the four groups of F(1) hybrid were compared and no significant differences were found. This was true in separate experiments, involving two mammary carcinomata and a 3-methylcholanthrene induced sarcoma, wherein the period of tumour growth in the parent line donor and F(1) hybrid recipient was varied.


Arthropod tissue culture in the study of arboviruses and rickettsiae: a review.


The response of immunologically reconstituted mice to allogeneic skin or tumour grafts.


Role of immunologic disturbance in human oncogenesis: some facts and fancies. A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and considers recent evidence concerning the relation between the clinical stage of the disease and its associated defect in cell-mediated immunity. Finally, the prior occurrence of infectious mononucleosis in some cases of Hodgkin's disease is considered in the context of the hypothesis that the neoplastic cells of Hodgkin's disease may evolve from a chronic immunologic reaction, analogous to that of graft-versus-host, stemming from the induction of antigenic alteration in a subpopulation of lymphocytes by certain types of non-neoplastic viral infections.


The short-term effects of 4-nitroguinoline 1-oxide on the immune response in mice.


Some properties of D-amino-acid oxidase apoenzyme from beef kidney.


Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes.


Drugs and the heart.

Drugs and the heart.


Ocular injuries due to jellyfish.

Ocular injuries due to jellyfish.


The prostate in the neonate and infant in cryptorchism and hypospadias.


Anesthetic activity of two steroid-17-spirolactones.


Recurrence of herpetic keratitis in corneal grafts.


A possible role of zinc in the metabolism of testosterone by the prostate gland.


Selective increases in type I hydrogen from reduced nicotinamide-adenine dinucleotide phosphate in liver from phenobarbitone-treated rats.


The effect of phenobarbitone on the production of type I hydrogen from reduced nicotinamide-adenine phosphate in different regions of the liver lobule.


Isoenzymes of glutamine synthetase in rat tissues.


Metabolism of m-tert.-butylphenyl N-methylcarbamate in insects and mice. The metabolism of m-tert.-butylphenyl N-methylcarbamate was studied in mice and five species of insects. Both the tert.-butyl group and the N-methyl group were hydroxylated. The major phenolic metabolite was m-(beta-hydroxy-tert.-butyl)phenol, which was identified by mass spectroscopy. Significant amounts of dihydroxy compounds were formed at a constant rate from the start of the enzymic oxidation process. The considerable species variation in the yields of the different types of oxidation products suggests that N-demethylation and oxidation of the tert.-butyl groups were catalysed by different enzymes. A microsomal NADPH-dependent enzyme also catalysed the splitting of the ester link in the insecticide.


Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions.


Biochemical adaptation of rat liver in response to marginal oxygen toxicity. 1. Hepatic glucose 6-phosphate dehydrogenase activity was increased in rats exposed to 5lb/in(2) (equivalent to 27000ft), 100% O(2) when compared with control animals in a 14.7lb/in(2) (sea level), air environment. Glyceraldehyde 3-phosphate dehydrogenase, isocitrate dehydrogenase, and succinate dehydrogenase were not affected by the 5lb/in(2), 100% O(2) environment. 2. Animals exposed to the hyperoxic environment consumed food, expired CO(2) and gained weight at the same rate as normoxic control animals. Additionally, blood glucose and liver glycogen concentrations were unchanged in the hyperoxic animals. The only readily apparent physiological difference in the hyperoxic animals was a decreased haematocrit. 3. The increase in glucose 6-phosphate dehydrogenase was eliminated by the injection of actinomycin D or cycloheximide. 4. Expiration of (14)CO(2) from [1-(14)C]glucose was approximately the same in hyperoxic and normoxic rats. However, (14)CO(2) expiration from [6-(14)C]glucose was markedly decreased in the animals exposed to the hyperoxic environment. 5. Calculations of the relative importance of the pentose phosphate pathway versus the tricarboxylic acid cycle plus glycolysis indicated that the livers from animals in the 5lb/in(2), 100% O(2) environment metabolized twice as much carbohydrate by way of the pentose phosphate pathway as did those from the sea-level air control animals. 6. In livers of rats exposed to 5lb/in(2), 100% O(2) the concentrations of pyruvate, citrate and 2-oxoglutarate were increased, that of isocitrate was slightly elevated, whereas the concentrations of succinate, fumarate and malate were decreased. 7. An inactivation of both tricarboxylic acid cycle lipoate-containing dehydrogenases, pyruvate and 2-oxoglutarate, under hyperoxic conditions is proposed. 8. The adaptive significance of the induction of glucose 6-phosphate dehydrogenase and the resultant production of NADPH under hyperoxic conditions is discussed.


Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate. 1. An assay for demethylation has been developed based on the release of tritium from 4,4-dimethyl[3alpha-(3)H]cholest-7-en-3beta-ol (II). 2. The maximum release of (3)H from 3alpha-(3)H-labelled compound (II) in a rat liver microsomal preparation occurs in the presence of NADPH and NAD(+) under aerobic conditions. 3. Incubation of 3alpha-(3)H-labelled compound (II) with NADPH under aerobic conditions leads to the formation of a 3alpha-(3)H-labelled C-4 carboxylic acid. This compound undergoes dehydrogenation on subsequent anaerobic incubation with NAD(+). 4. The (3)H released from the steroid was located in [4-(3)H]nicotinamide and the medium. Incubation with synthetic [4-(3)H(2)]NADH gave a similar result. 5. In the presence of glutamate dehydrogenase and alpha-oxoglutarate part of the (3)H released from the steroid was transferred to glutamate. 6. A series of 3-oxo steroids were reduced equally well by [4-(3)H(2)]NADH and [4-(3)H(2)]NADPH. The reduction of 5alpha-cholest-7-en-3-one was shown to use the 4B H atom from the nucleotide. 7. 3':5'-Cyclic AMP was shown to be a competitive inhibitor of the 3beta-hydroxy dehydrogenase enzyme in the demethylation reaction.


Induction of rat liver tyrosine aminotransferase by pharmacologically unrelated drugs.


Occurrence of esters of (15S)-prostaglandin A 2  and E 2  in coral.


Microbial oxidation of amines. Partial purification of a mixed-function secondary-amine oxidase system from Pseudomonas aminovorans that contains an enzymically active cytochrome-P-420-type haemoprotein. 1. Crude extracts of Pseudomonas aminovorans grown on methylamine, di-methylamine, trimethylamine or trimethylamine N-oxide contain an enzyme or enzyme system catalysing the NADH- or NADPH- and oxygen-dependent oxidation of dimethylamine to methylamine and formaldehyde. 2. The enzyme has been partially purified about five-fold. It is unstable, but can be stabilized by addition of 5% (v/v) ethanol. 3. The partially purified enzyme will utilize either NADH (K(m) 6.5mum) or NADPH (K(m) 13.2mum): The following secondary amines have been shown to be substrates: dimethylamine, ethylmethylamine, diethylamine, methyl-n-propylamine, ethyl-n-propylamine, n-butylmethylamine and N-methylethanolamine. The K(m) values and comparative reaction rates for each substrate have been determined. Where the alkyl groups are different, the aldehyde products are derived from both groups. 4. The enzyme system has a pH optimum of 6.8 and is inhibited by mercurials, thiol compounds, cyanide and carbon monoxide. 5. The partially purified preparation had a spectral maximum at 412nm with shoulders at 427 and 550nm. Reduction with dithionite or NAD(P)H bleached the 412nm peak, and the shoulder at 427nm became a peak. Additional peaks appeared at 550 and 580-588nm. Reduction of a preparation bubbled with carbon monoxide enhanced and sharpened the Soret peak and caused it to shift to 422nm. 6. Analysis of the preparation showed the presence of flavin, acid-extractable iron and non-acid-extractable iron in the proportion 1.1:1.9:1. On reduction with dithionite or NADPH the preparation showed an electron-paramagnetic-resonance signal at around g=1.946.


Isolation of a new naturally occurring prostaglandin, 5-trans-PGA 2 . Synthesis of 5-trans-PGE 2  and 5-trans-PGF 2a .


Alterations in pancreatic beta cells induced by cyclizine.


Testicular degeneration and necrosis induced by chlorcyclizine.


Role of alpha-adrenergic blockade on alanine-induced hyperglucagonemia.


The effect of temperature on the survival of microorganisms in a deep space vacuum.


Exaggerated intestinal glucagon and insulin responses in human subjects.


Elements and patterns in diagnostic discrimination learning.


Embryogenesis in 100 per cent O 2  at reduced pressure.


Bluetongue disease.

Bluetongue disease.


Complications of viral hepatitis.

Complications of viral hepatitis.


Development of glucose-6-phosphate, malate, and glutamate dehydrogenase activities in the ventral half of the chick spinal cord in the absence of extrinsic neuronal connections.


A chemical and pharmacological study on the role of catecholamines in the dispersion reaction of Xenopus laevis.


Distinction between two microsomal activities of NADH cytochrome c reductase by means of Triton X-100.


Man versus mean: the exploitation of group profiles for the construction of diagnostic classification systems.


A search for lymphocyte-derived macrophages during xenogeneic graft-verus-host reactions induced by rat thoracic duct cells.


Free flow electrophoretic separation of bone marrow cells. Electrophoretic distribution analysis of in vivo colony forming cells in mouse bone marrow.


Raynaud's phenomenon in an infant.

Raynaud's phenomenon in an infant.


The use of 13 C n.m.r. (c.m.r.) spectroscopy in biosynthetic studies of - lactam antibiotics. I. The incorporation of (1- 13 C)- and (2- 13 C) sodium acetate, and DL-(1- 13 C)- and DL-(2- 13 C) valine into cephalosporin C.


Thirthy years of penicillin therapy.

Thirthy years of penicillin therapy.


The development of commercial processes for the production of 6-aminopenicillanic acid (6-APA).


Structure-activity relationships in semi-synthetic penicillins.


Chemical relationships between cephalosporins and penicillins.


How penicillin kills bacteria: progress and problems.


The function and evolution of penicillinase.


Bacterial resistance to penicillins and cephalosporins.


Fire ant allergy.

Fire ant allergy.


On the immunological properties of penicillins.


Intestinal polyarteritis nodosa: a surgical impasse?


Enzyme histochemistry of experimental embryo-derived teratocarcinomas.


Brugia infections in man and animals: long-term observations on microfilaraemia and estimates of the efficiency of transmission from mosquito vector to definitive host.


Pigment systems and electron transport in chloroplasts. II. Emerson enhancement in broken spinach chloroplasts.


Ferredoxins in light- and dark-grown photosynthetic cells with special reference to Rhodospirillum rubrum.


The role of molybdenum in the synthesis of Neurospora nitrate reductase.


Effect of heat treatment on the activity in vitro of nitrate reductase from Cyanidium caldarium.


The haemodynamic effects of ( )-propranolol, dexpropranolol, oxprenolol, practolol and sotalol in anaesthetised dogs.


Effects of various antihistamines on oxotremorine-induced hypothermia in mice.


Analysis of the adrenergic receptors of pacemaker and myocardial cells.


Blood sugar responses to epinephrine in the dog in the presence of dual adrenergic blockade.


Ganglion-blocking activity of bisquaternary ammonium salts derived from 3 ,12 -diamino-5 -cholane and 3 ,12 -diamino-24-nor-5 -cholane.


The effect of clonidine on human isolated smooth muscle.


Adrenergic mechanisms in the development of hypothermic ventricular fibrillation in the isolated perfused heart of the cat.


The effect of psychotomimetic glycolate esters on central monoamine neurons.


Crithidia fasciculata: acriflavine-induced changes in soluble enzyme levels.


The isolation and primary structure of a peptide containing the oxidation-reduction active cystine of Escherichia coli thioredoxin reductase.


Effects of mosquitoes on the average daily gain of feedlot steers in southern Louisiana.


D-Fucose metabolism in a pseudomonad. II. Oxidation of D-fucose to D-fucono- -lactone by an L-arabino-aldose dehydrogenase and hydrolysis of the lactone by a lactonase.


The action of choline on the superior cervical ganglion of the cat.


Modification by two beta-adrenergic blocking drugs of the effects of methamphetamine on behaviour and brain metabolism of mice.


The particle-size of sulphadiazine produced by a solvent-change method.


Solute migration during granule drying.

Solute migration during granule drying.


The kinetics of crystallization of potassium bromide from aqueous solution.


The dissolution times of spherical particles.


Alkaloids from two Nigerian species of Fagara.


Inactivation of resistant Pseudomonas aeruginosa by antibacterial combinations.


Phenylethanol enhancement of preservatives used in ophthalmic preparations.


The in vitro evaluation of gelatin coacervate microcapsules.


Further studies on the effect of additives on the release of drug from hard gelatin capsules.


Hydrophobic bonding in soap-stabilized emulsions.


A polarographic method for the determination of flurandrenolone.


The determination of residual ethylene oxide and halogenated hydrocarbon propellants in sterilized plastics.


Digital filters in the evaluation of titration curves.


The effect of starch type, concentration and distribution on the penetration and disruption of tablets by water.


A comparison of granules prepared by pan granulation and by massing and screening.


Computer analysis of the relation between tablet strength and compaction pressure.


The effect of granule shape on bulk density, shear properties and tablet weight variation.


Automatic weight-control in a rotary tabletting machine.


The application of photoelastic techniques to a rotary tabletting machine.


The properties of tablets made from direct-compression bases on an automatically controlled rotary machine.


Contribution of slip and knudsen flow to tablet permeability measurements.


A stable free radical for the investigation of hydrogen abstraction reactions in aqueous solution.


The effect of pH on the aerobic degradation of ascorbic acid solutions.


The compaction properties of potassium bromide with particular reference to infrared spectroscopy.


The effect of pore size of the inhaler support upon the concentration of volatile drug emerging in the air stream from a nasal inhaler.


The sorption of benzocaine by nylon 6 (polycaprolactam).


In vitro and in vivo studies of the metabolism of phenylbutazone in the alloxan rat and rabbit.


Metabolism of 5,8,11,14-eicosatetraynoic acid in the rat.


Metabolism, distribution and excretion of orphenadrine in man.


Metabolism and excretion of guanoxan in human.


Interactions between phosphatidylethanolamine monolayers and phenols in relation to antibacterial activity.


Anti-anginal drugs and the vasodilator response to myocardial hypoxia.


The effects of quazodine on myocardial blood flow in developing myocardial infarcts.


Muscle tremor produced by sympathomimetic bronchodilators.


Actions of the sympathomimetic bronchodilator, AQL208, on the cardiovascular, bronchiolar and skeletal muscle systems of the cat.


The hyperglycaemic effect of the diuretic chlorthalidone.


Mechanism of action of neostigmine at the neuromuscular junction.


The actions of depolarizing drugs and antagonists on developing muscle fibres in vitro.


The influence of cellular metabolism on the  - and  -adrenoceptor responses of the rabbit small intestine.


The extraction and estimation of histamine from Gossypium species.


The estimation of rauwolfia alkaloids by quantitative thin-layer chromatography.


The titrimetric assay of solasodine, a spirosolane of commercial importance from solanum laciniatum ait.


The determination of diosgenin and yamogenin in fenugreek seed by combined column chromatography and infrared spectrometry.


The composition and distribution of phytosterols in Digitalis purpurea L.


The characterization of alkaloid D, a new alkaloid from Euonymus europaea L., as armepavine.


The preservation of ophthalmic solutions with antibacterial combinations.


Polyphenolases in the 1000 g fraction of papaver somniferum latex.


Effects of drying on polymyxin sensitivity of pseudomonas aeruginosa.


Effect of slime on the sensitivity of pseudomonas aeruginosa to EDTA and polymyxin.


Metabolism of 3-deoxy-3-fluoro-D-glucose by Pseudomonas aeruginosa.


The anactivation of phenylmercuric nitrate by sodium metabisulphite.


Progress towards a standard to limit particulate contamination in intravenous fluids.


Some investigations of the effect of a non-ionic surfactant on the diffusion of hydrocortisone across a cellulose acetate membrane.


Kinetics of structure build-up in self-bodied emulsions stabilized by mixed emulsifers.


Prediction of the micellar molecular weight and thermodynamics of micellization of mixtures of alkyltrimethylammonium salts.


The solubilization of salicylic acid by a series of non-ionic surfactants.


Monomer concentrations in micellar drug systems.


The tertiary alkaloids of some asian species of strychnos.


The use of methylene chloride and chloroform for the extraction of tertiary alkaloids from Strychnos species.


The conversion of pseudo heteroyohimbine alkaloids to oxindole alkaloids.


The distribution of alkaloids in Mitragyna parvifolia (Roxb.) Korth in young plants grown from Ceylon seed.


A study of bioavailabilities and dissolution rates of commercial tablets of nitrofurantoin.


On the effect of pharmaceutical formulation on thioridazine absorption.


Human volunteer studies of the antitussive activity of dropropizine.


2-Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase.


Extrinsic circular dichroism resulting from the interaction of sulphonamides with plasma albumin.


The soda lime pyrolysis of saccharin.

The soda lime pyrolysis of saccharin.


Impurity profiles of pharmaceutical colourants.


Effect of sodium carboxymethylcellulose and compound tragacanth powder on the sedimentation and redispersal of sulphadimidine mixture, paediatric B.P.C. 1968.


A possible mechanism for the action of dimethyl sulphoxide on percutaneous absorption.


Sensory testing of spreadability; investigation of the rheological conditions operative during application of topical preparations.


The effect of constituents in white soft paraffin on the efficacy of corticosteroid ointments in the vasoconstrictor test.


Correlation of bactericidal properties of the  , , -trifluoromethylphenols with physico-chemical parameters.


The heat resistance of bacterial spores after different vacuum drying treatments.


Recognizing sporogenous yeast genera.

Recognizing sporogenous yeast genera.


The effect of cetyltrimethylammonium bromide on the cytochrome system of Escherichia coli.


Studies on mixing cohesive powders.

Studies on mixing cohesive powders.


The mixing of micronized sodium bicarbonate with sucrose crystals.


Preliminary compaction studies using a device to simulate a rotary tabletting machine.


The modifying effects of a cationic surfactant on the rates of base catalysed hydrolysis of esters of different structures.


An evaluation of five commercially available tablet disintegrants for possible use in insoluble direct compression systems.


Effect of compaction pressure on dissolution times of some direct compression systems.


The effect of detergent concentration on monomer activity in a non-ionic detergent solution.


The solubility of some compounds in hexadecylpolyoxyethylene monoethers, polyethylene glycols, water and hexane.


Identification of the site of solubilization of various compounds by cetomacrogol.


The influence of the surface tension of pendular bonds on the tensile strength of moist beds of bulk solids.


The effect of smoking on nicotine metabolism in vivo in man.


A new buccal absorption model.

A new buccal absorption model.


The analysis of nicotine-1'-N-oxide in urine, in the presence of nicotine and cotinine, and its application to the study of in vivo nicotine metabolism in man.


Buccal absorption as a parameter of analgesic activity of some p-substituted acetanilides.


Membrane osmometry of solubilized systems.


A laser light scattering apparatus.

A laser light scattering apparatus.


Adsorption of phosphatidylcholine at the benzene-water interface.


The adsorption of crystal violet by kaolin.


An approach to the dizzy patient.

An approach to the dizzy patient.


A study of twelve applicants for transsexual surgery.


The cardiovascular responses to the addition of nitrous oxide to fluroxene in man.


Ulcerative colitis, diverticulitis and the irritable colon syndrome.


Cell-mediated immune response in vitro. II. The role of thymus and thymus-derived lymphocytes.


Pulmonary vascular and cardiac effects of glucagon before and after adrenergic beta-receptor blockade.


An estimate of the muscarinic ganglion blocking potency of atropine.


The use of a membrane feeding technique for infecting mosquitoes with filarial worms transported between laboratories.


Alkaline phosphatase in the cytoplasmic droplet of mammalian spermatozoa.


The role of post-synaptic neurones in the biochemical maturation of presynaptic cholinergic nerve terminals in a mouse sympathetic ganglion. 1. The role of post-synaptic adrenergic neurones in the biochemical maturation of presynaptic cholinergic nerve terminals has been investigated in mouse superior cervical ganglion in vivo.2. Selective destruction of ganglion adrenergic neurones chemically, with 6-hydroxydopamine (6-OH-DA), or immunologically, with nerve growth factor antiserum (NGF-antiserum) prevented the normal maturation of choline acetyl transferase (ChAc) activity in presynaptic endings during development. Enzyme activity remained depressed for at least 2 months.3. 6-OH-DA treatment failed to alter ChAc activity in the developing duodenum or diaphragm, organs in which cholinergic fibres do not synapse with adrenergic neurones, suggesting that destruction of post-synaptic neurones per se inhibited presynaptic maturation.4. Similarly, NGF-antiserum, which does not destroy adrenergic neurones in the adult did not alter ChAc activity in adult mouse ganglia.5. These observations suggest that post-synaptic adrenergic neurones regulate the biochemical development of presynaptic cholinergic nerve terminals.


Monosynaptic testing of synaptic efficiency and motoneurone excitability.


A study of glucose and xylose oxidation catalyzed by the glucose-6-phosphate dehydrogenase of rat liver cytosol.


Steroid hydroxylations in rat adrenal mitochondria. IV. An inhibition of NADH oxidase and succinate-supported deoxycorticosterone hydroxylation by steroid and rotenone.


Toxic epidermal necrolysis in a patient with graft-vs-host reaction.


Prostaglandins and resistance to beta adrenoceptor stimulants.


Mediastinal endocrine neoplasm in patients with multiple endocrine adenomatosis. A previously unrecognized association.


Doctor of primary medicine(PMD).

Doctor of primary medicine(PMD).


Determination by gel filtration of association constants for metal-nucleotide interaction.


Study on the effect of cyclophosphamide on experimental rickettsial infection.


Cardiovascular response in hyperthyroidism. The influence of adrenergic-receptor blockade.


The dentition of patients suffering on different types of scleroderma.


Mechanisms of renal excretion of drugs (with special reference to drugs used by anaesthetists).


Comparison of a new beta adrenergic blocker (MK 950) and propranolol in man.


Escherichia coli pyridine I-oxide reductase.


Caries-protective effect of diabetic diet? A clinical investigation on young diabetics.


Effect of route of administration on the relationship between  -adrenergic blockade and plasma propranolol level.


Regional lymph node weight increase by semisyngeneic cells and the possible role of a non-immunological recognition process in transplantation. (GvHR-whole-body irradiation-in vitro irradiation-freezing-thawing).


14th Aspen Conference on Research in Emphysema.


The effect of dimethyl sulphoxide on the ability of spleen cells to produce splenomegaly and hepatomegaly. (GvHR-preservation by freezing).


Abolition of in vitro cytotoxicity of sensitized lymph node cells by regional graft-versus-host reaction. (Immunosuppression-adoptive transfer of immunity).


Maggasauga rattlesnake bite in the Chicago area.


The univalent reduction of oxygen by reduced flavins and quinones.


Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. I. Magnetic resonance and binding studies of the complexes of enzyme, manganous ion, and substrates.


Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues.


Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.


Methodological issues and racial (black-white) comparisons on the MMPI.


"Spontaneous remission" of deviant MMPI profiles among college students.


Lithium carbonate-induced myxedema.

Lithium carbonate-induced myxedema.


Influence of oxprenolol on adrenaline-induced reflex bradycardia in dogs.


The effect of template molecular weight alteration on transcription by Escherichia coli RNA polymerase.


The effect of thymoxamine on histamine induced bronchospasm in man.


A study on liver actions of glucocorticoids.


Dihydrofolate reductase activity in strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin. Resistance to the antifolates methasquin and amethopterin has been studied in new strains of Streptococcus faecium var. durans. Two methasquin-resistant strains (SF/MQ, SF/MQ(T)) and an amethopterin-resistant strain (SF/AM) were selected independently from the wild-type S. faecium var. durans (SF/O). SF/MQ(T) is a thymine auxotroph. Total dihydrofolate reductase activity was elevated in each of the resistant strains. The greatest increase (36-fold) was observed in extracts of SF/AM. The methasquin-resistant strains, SF/MQ and SF/MQ(T), had 29-fold and 8-fold, respectively, more dihydrofolate reductase activity than the parental strain. Total dihydrofolate reductase activity of SF/O was separable by gel filtration into two components: a folate reductase (11%) and a specific dihydrofolate reductase (89%). Folate reductase activity was associated with 88% of the total dihydrofolate reductase activity of SF/MQ(T), with specific dihydrofolate reductase activity accounting for the remaining 12%. In SF/MQ and SF/AM, folate reductase activity was associated with 97% of the total dihydrofolate reductase activity. Studies of the inhibition by methasquin and amethopterin of partially purified folate reductase and specific dihydrofolate reductase of the mutant strains suggested that resistance was not accompanied by changes in the affinities of these enzymes for either antifolate.


Glucose-6-phosphate dehydrogenase from Escherichia coli and from a "high-level" mutant. Glucose-6-phosphate dehydrogenase has been purified to near homogeneity from wild-type Escherichia coli K-12 and from a mutant previously found to contain substantially more of the enzyme. The two enzymes are the same in all characteristics studied thus far: specific activity, kinetics, specificity, and subunit size.


Ferredoxin- and nicotinamide adenine dinucleotide-dependent H 2  production from ethanol and formate in extracts of S organism isolated from "Methanobacillus omelianskii". S organism ferments ethanol to acetate and H(2) but grows poorly on ethanol unless the partial pressure of H(2) is kept low, as when it is grown in combination with an H(2)-utilizing methanogenic bacterium. The present study shows that S organism contains an alcohol dehydrogenase and a formate dehydrogenase, both of which require nicotinamide adenine dinucleotide (NAD) for activity. Hydrogen is evolved from NADH generated by these activities via a ferredoxin-dependent oxidation of NADH to NAD and H(2). NADH:NADP oxido-reductase activity was also demonstrated. The relationship of these activities to the growth of S organism is discussed.


Adenyl cyclase activity in the mouse thyroid gland.


The availability of NADPH for corticosterone reduction in six strains of mice.


Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells. Two types of thymus-derived (T) lymphocytes have been shown to cooperate in the induction of graft-versus-host responses. One cell type is found in highest concentrations in the peripheral blood and lymph node, is extremely sensitive to anti-thymocyte serum (ATS) in vivo, and is probably part of the recirculating lymphoid cell pool (3). The second cell type, found in highest concentrations in the thymus and spleen, is relatively resistant to small doses of ATS in vivo. Both cell types are substantially depleted after neonatal thymectomy. Moreover, since synergism was also obtained using appropriate mixtures of cells from either parental strain in F(1) hosts, it was possible to show that the nonrecirculating cells determined the specificity of the response and were probably the precursors of effector cells in this response. The recirculating T cell appeared to amplify this response. The implications of these data are discussed.


Purification of tetrahydrofolate dehydrogenase by affinity chromatography.


The pathway of glutamine and glutamate oxidation in isolated mitochondria from mammalian cells. 1. Pyruvate strongly inhibited aspartate production by mitochondria isolated from Ehrlich ascites-tumour cells, and rat kidney and liver respiring in the presence of glutamine or glutamate; the production of (14)CO(2) from l-[U-(14)C]glutamine was not inhibited though that from l-[U-(14)C]glutamate was inhibited by more than 50%. 2. Inhibition of aspartate production during glutamine oxidation by intact Ehrlich ascites-tumour cells in the presence of glucose was not accompanied by inhibition of CO(2) production. 3. The addition of amino-oxyacetate, which almost completely suppressed aspartate production, did not inhibit the respiration of the mitochondria in the presence of glutamine, though the respiration in the presence of glutamate was inhibited. 4. Glutamate stimulated the respiration of kidney mitochondria in the presence of glutamine, but the production of aspartate was the same as that in the presence of glutamate alone. 5. The results suggest that the oxidation of glutamate produced by the activity of mitochondrial glutaminase can proceed almost completely through the glutamate dehydrogenase pathway if the transamination pathway is inhibited. This indicates that the oxidation of glutamate is not limited by a high [NADPH]/[NADP(+)] ratio. 6. It is suggested that under physiological conditions the transamination pathway is a less favourable route for the oxidation of glutamate (produced by hydrolysis of glutamine) in Ehrlich ascites-tumour cells, and perhaps also kidney, than the glutamate dehydrogenase pathway, as the production of acetyl-CoA strongly inhibits the first mechanism. The predominance of the transamination pathway in the oxidation of glutamate by isolated mitochondria can be explained by a restricted permeability of the inner mitochondrial membrane to glutamate and by a more favourable location of glutamate-oxaloacetate transaminase compared with that of glutamate dehydrogenase.


Lysine biosynthesis in Saccharomyces. Conversion of  -aminoadipate into  -aminoadipic  -semialdehyde. The reduction of alpha-aminoadipate to alpha-aminoadipic delta-semialdehyde by a cell-free extract of Saccharomyces is shown to be a three-step process. First the amino acid reacts with ATP to form an adenylyl derivative. Then the adenylyl derivative of alpha-aminoadipate is reduced in the presence of NADPH. In the third step the reduced adenylyl derivative of the amino acid is cleaved to form alpha-aminoadipic delta-semialdehyde. The presence of Mg(2+) is necessary for the first and second steps. The third step does not need any cofactors. The product of the first step was isolated by chromatography after incubating the cell-free extract of Saccharomyces with alpha-aminoadipate, ATP and Mg(2+). The isolated product was identified as an adenylyl derivative of alpha-aminoadipate and could be converted into alpha-aminoadipic delta-semialdehyde under the stated experimental conditions. The product of the second step was too unstable to be identified.


Steady-state kinetics of mitochondrial nicotinamide nucleotide transhydrogenase. 2. The energy-linked reaction.


Clinical evaluation of an aged stannous fluoride-calcium pyrophosphate dentifrice.


Early behavioural effects of intraventricular administration of 6-hydroxydopamine in rat.


Reductive dechlorination of DDT by heated liver.


The validity of the psychoanalytic theory of paranoid dynamics. Evaluated from the available experimental evidence.


Cytochemical studies of protein transport in the nervous system.


Mediators of tissue damage in human polymorphonuclear neutrophils.


Biosynthesis of 5,6-dimethylbenzimidazole. Precursor-function of 6,7-dimethyl-8-ribityllumazine.


Molecular interaction of L-tryptophan with bases, ribonucleosides and DNA.


Synthesis and turnover of membrane proteins in rat liver: an examination of the membrane flow hypothesis.


Activation of protein synthesis in aging potato tuber slices.


Synthesis of rRNA, tRNA and other RNA-species concomitant with polyribosome formation in aging potato tuber slices.


Uptake of polynucleotides by mouse ascites tumor cells. X. pH-dependent uptake of synthetic homoribopolymers.


Tachyarrhythmia in severe imipramine overdose controlled by practolol.


Experience of routine live-birth screening for galactosaemia in a British hospital, with emphasis on heterozygote detection.


Scanning electron microscopy of bacterial colonies. I. Diplococcus pneumoniae and Streptococcus pyogenes.


The response of the sweat glands to  -adrenergic stimulation.


Desdanine, an inhibitor of oxidative phosphorylation in mitochondria.


Surface immunoglobulins on bursa-derived chicken lymphoid cells.


Current treatment of angina: what do we know?


Some studies on acute inflammation induced by dextran in the mouse.


Human bone marrow transplantation.

Human bone marrow transplantation.


The clinical application of antilymphocyte globulin.


The future of transplantation immunology.


Chemical mediators of the vascular phenomena of the acute inflammatory reaction and of immediate hypersensitivity.


Systemic mastocytosis.

Systemic mastocytosis.


Management of glaucoma.

Management of glaucoma.


Microfluorometry of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in red cells.


The histochemical localization of glucose dehydrogenase activity in sheep liver.


Quantitative determination of oxidized pyridine nucleotides by a paper chromatographic technique.


Physical, symptomatic and psychological improvement in patients receiving comprehensive care for chronic airway obstruction.


Wind factors in the operation of a cylindrical bait trap for mosquitoes.


Isolations of trivittatus virus from Wisconsin mosquitoes, 1964-1968.


Relationships between surface activity and biological activity of drugs.


Treadmill exercise in dogs under  -adrenergic blockade: adaptation of coronary and systemic hemodynamics.


Beta-adrenergic blockade and antiarrhythmic activity of (-)- and (+)-propranolol.


Mechanisms of ocular ischaemia.

Mechanisms of ocular ischaemia.


Microbiological assay of josamycin.

Microbiological assay of josamycin.


Suppression of cardiac allograft rejection in adult rats by pretreatment with bone marrow cells. Immunological enhancement.


Familial multiple endocrine adenomatosis. Multiple endocrine neoplasia, type I.


NAD(P) +  redox compartmentation in Ehrlich ascites tumour cells.


Role of cyclic photophosphorylation in photosynthetic carbon dioxide assimilation by isolated chloroplasts.


Effect of cold-storage of bean leaves on photosynthetic reactions of isolated chloroplasts. Inability to donate electrons to photosystem II and relation to manganese content.


Time as a dimension of affects.

Time as a dimension of affects.


Sodium and the flux of calcium ions in electrically-stimulated cerebral tissue.


Metal chelates in the storage and transport of neurotransmitters: formation of mixed ligand chelates of Mg 2+ -ATP with biogenic amines.


Tyrosine hydroxylase in rat brain: developmental characteristics.


Metabolism of putative transmitters in individual neurons of Aplysia californica: aromatic amino acid decarboxylase.


Clinical trial of a beta-receptor blocking agent (LB 46) in migraine prophylaxis.


Third International Symposium on Gastrointestinal Motility. Stockholm, September 1971. Summary comments on session on electrophysiology.


-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.


Purification, characterization and properties of nitrite reductase of Achromobacter fischeri.


The effect on personality of reactivity to 1,2-dimethyl-heptyl tetrahydrocannabinol.


Delayed hypersensitivity and allergic rhinitis. A negative study.


Neurological and neuropsychological effects of botulinum toxin.


Studies of a flavoprotein, salicylate hydroxylase. I. Preparation, properties, and the uncoupling of oxygen reduction from hydroxylation.


Chinese hamster liver glutamine synthetase. Purification, physical and biochemical properties.


Amino acid transport in membrane vesicles of Bacillus subtilis.


Coronary artery disease and antihypertensive drugs.


Comparative effects of sotalol and propranolol on contractility of papillary muscles and adenyl cyclase activity of myocardial extracts of cat.


Cognitive style and sexual identity.

Cognitive style and sexual identity.


A comparison of isoprenaline, salbutamol, and rimiterol inhalation on skin temperature, heart rate, and respiration in man.


A new actuarial system for MMPI interpretation: rationale and methodology.


The factor structure of the Tennessee Self-Concept Scale among lower-class urban psychiatric patients.


The effect of serving as a psychotherapist on students with different specialty preferences.


Mechanism of action of luteinizing hormone.


Beta-adrenergic stimulation of transmembrane potential and short circuit current of isolated rabbit oviduct.


Adenyl cyclase and the differentiation of  -adrenoreceptors.


-Adrenergic blockade with practolol in acetylcholine-sensitive asthma patients.


Studies on the bioluminescence of Renilla reniformis. XI. Location of the sulfate group in luciferyl sulfate.


Water relations of the chinchilla Chinchilla laniger.


Iatrogenic alterations of immunologic surveillance in man and their influence on malignancy.


Effect of trinitrophenylation of specific lysyl residues on the catalytic, regulatory, and molecular properties of bovine liver glutamate dehydrogenase.


Early actions of cadmium in the rat and domestic fowl. VI. Testicular and muscle blood flow changes.


Studies on the concentration of myoglobin in the sea-cow and porpoise.


Heating and cooling rates in four species of turtles.


Excretion of urate salts by reptiles.

Excretion of urate salts by reptiles.


Spherical precipitates in the urine of reptiles.


Biology of Myotis thysanodes and M. lucifugus (Chiroptera: Vespertilionidae). I. Thermoregulation.


The effects of toxic components of Naja nivea (Cape cobra) venom on neuromuscular transmission and muscle membrane permeability.


The relationship between gas and ion transfer across the gills of fishes.


Validation of the thermodilution technique for the estimation of cardiac output in the rat.


Cardiac output of ducks during diving.

Cardiac output of ducks during diving.


Estimation of cardiac output by thermodilution in the conscious lactating rat.


Renal salt and water excretion in the budgerygah (Melopsittacus undulatus).


The effect of temperature on transmission at the neuromuscular junction of the sartorius muscle of Rana pipiens.


The role of the endocrine system in temperature-controlled reproductive cycling in the estuarine gobiid fish, Gillichthys mirabilis.


Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture.


Age-dependent regulation of glucokinase and tyrosine aminotransferase activities of rat liver in vivo by adrenal, pancreatic and pituitary hormones.


Drug therapy in hypertension.

Drug therapy in hypertension.


Uptake of the putative neurotransmitter, glycine, into the rabbit retina.


The syniatrist: a prayer answered.

The syniatrist: a prayer answered.


Possible cyclic adenosine monophosphate mediation in isoproterenol-induced suppression of cell division in rat lens epithelium.


Definition and antagonism of histamine H 2 -receptors.


Torsion of intra-abdominal testis: an unusual problem in diagnosis of the acute surgical abdomen.


Use of physician associates.

Use of physician associates.


Water and electrolyte transfer by colonic mucosa studied in vitro.


Evaluation of the components of a dental public health program through the screening of lower first permanent molars.


Determination of serum or plasma glucose on the "AutoAnalyzer II" by use of the hexokinase reaction.


INteractions between the thermoregulatory responses to injections into a lateral cerebral ventricle of the Welsh Mountain sheep of putative neurotransmitter substances, and of local changes in anterior hypothalamic temperature.


Effects of beta-adrenoreceptor blocking agents on the deslanoside-induced arrhythmia and cardiac arrest in guinea pigs.


Blood vessel disease in diabetes mellitus. V. Capri Conference, 7-8 IV 1971.


Considerations in the development of remote health care systems.


Development and juvenile growth of the sea anemone, Tealia crassicornis.


Models of remote health care systems.

Models of remote health care systems.


Laboratory colonization of Aedes simpsoni (Theobald) and Eretmapodites quinquevittatus Theobald.


Hydrogen-ion concentration in breeding habitats of Culex pipiens fatigans (Wied.) and associated mosquitos.


Hypopyon corneal ulcers in rural Bengal.


Some aspects of the biosynthesis of phytosterols and triterpenes.


Lethal Escherichia coli septicemia in the baboon: alpha-adrenergic inhibition of insulin secretion and its relationship to the duration of survival.


Substrate activation in pyridine nucleotide-linked reactions: illustrations from the steroid field.


Steroids in meconium and faeces from newborn infants.


Biosynthesis of cardenolides, bufadienolides and steroid sapogenins.


Recent investigations on the nature of sterol intermediates in the biosynthesis of cholesterol.


Metabolic pathways of steroids in insects.


Radiologists look at physician's assistants in radiology.


The sterols of echinoderms.

The sterols of echinoderms.


Acute sinusitis. A clinical bacteriological and serological study with special reference to Haemophilus influenzae.


Active enhancement of rat renal allografts with soluble splenic antigen.


Enhanced hepatic metabolism of testosterone, 4-androsterone-3,17-dione, and estradiol-17  in chickens pretreated with DDT or PCB.


Hormonal treatment of undescended testes and immunogenic properties of HCG.


WHO on stroke.

WHO on stroke.


Chronic beta adrenergic blockade in arterial hypertension. Hemodynamic influences of dihydralazine and dynamic exercise and clinical effects of combined treatment.


Five families with multiple endocrine adenomatosis.


Comparative properties of schistosomal and filarial dihydrofolate reductases.


Properties of dopamine  -hydroxylase in soluble and particulate fractions of bovine adrenal medulla.


Heterogeneity of guinea-pig homocytotropic antibodies.


Selective inhibition of viral functions: the antiviral action of interferon and streptovaricin.


Viral chemotherapy: its promise and problems.


Isolation of the vaccine strain of Venezuelan equine encephalomyelitis virus from mosquitoes in Louisiana.


The effects of temperature on fluroxene, halothane, and methoxyflurane blood--gas and cerebrospinal fluid--gas partition coefficients.


Hepatic microsomal lipoperoxidation and inhalation anesthetics: a biochemical and morphologic study in the rat.


Induction of phosphoenolpyruvate carboxykinase by N 6 , O 2 '-dibutyryl cyclic AMP in rat liver.


A peroxidative mechanism for the nonenzymatic reduction of metmyoglobin.


Hormonal effects on the neural retina: corticoid uptake, specific binding and structural requirements for the induction of glutamine synthetase.


Pyridine nucleotide metabolism in stored human erythrocytes.


Quantitative studies on antigenic recognition. 3. Nonspecific inhibition of the recognition process.


Contraction of the rat colon by sympathomimetic amines: effect of methysergide and 5-HT desensitization.


Stimulation of renin secretion in dogs by theophylline.


Influence of temperature on recovery of inhibition by antihistaminics and  -haloalkylamines toward histamine.


Pharmacological effects of two new  -adrenoceptor blocking drugs: Kö 1366 and Kö 1313.


Synergy among lymphoid cells mediating the graft-versus-host response. IV. Synergy in the GVH reaction quantitated by a mortality assay in sublethally irradiated recipients. A mortality assay was used to quantitate graft-versus-host (GVH) reactions in sublethally irradiated (400 R) neonatal (C57BL/6 x BALB/c)F(1) recipients of BALB/c lymphoid cells from various tissues. The probit of the 35 day cumulative per cent of mortality was a linear function of the logarithm of the cell inoculum for any tissue; reactivities of different tissues fell on a series of parallel lines. Peripheral blood leukocytes (PBL), the most active cells, were about 30 times as active as thymocytes, the least active cells studied; femoral lymph node cells and spleen cells were about 23 and 8 times as reactive as thymocytes, respectively. The average survival time of recipients of thymocytes who eventually died was nearly a week longer than that of recipients of comparably lethal numbers of PBL, lymph node, or spleen cells. Mixtures of PBL and thymocytes gave levels of 35 day mortality significantly greater than those expected if the reactivities of the mixture had been merely the sum of the reactivities of the components measured separately, thereby confirming in any assay independent of host splenomegaly the synergistic interaction of thymocytes and PBL in the GVH reaction. Both populations of cells in the mixture had to be allogeneic to the host in order to observe this synergy. The kinetics of cumulative mortality observed for mixtures of PBL and thymocytes were indistinguishable from those seen with thymocytes alone, indicating activation of the latter cell type. Finally, comparison of the relative abilities of different cell populations to cause splenomegaly on the one hand and lethal runting on the other has raised the possibility that expression of different effector functions of cell-mediated immune reactions may in fact be initiated by distinct cells.


Regulation of nitrate reductase in Neurospora crassa: stability in vivo. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH)-nitrate reductase and its related enzyme activities, NADPH-cytochrome c reductase and reduced benzyl viologen-nitrate reductase, are all induced following the transfer of ammonia-grown wild-type Neurospora mycelia to nitrate medium. After nitrate reductase is induced to the maximal level, the addition of an ammonium salt to, or the removal of nitrate from, the cultures results in a rapid inactivation of nitrate reductase and its two partial component activities. This rapid inactivation is slowed down by the protein synthesis inhibitor, cycloheximide. Experiments on the mixing of extracts in vitro rule out the presence of an inhibitor of nitrate reductase in free form in extracts containing inactivated nitrate reductase. Ammonia does not inhibit the uptake of nitrate by the mycelia. Inactivation of nitrate reductase in vivo by ammonia depends on the concentration of the ammonium salt and is not reversed by increasing the nitrate concentration of the medium. The nitrate-inducible NADPH-cytochrome c reductase activity and reduced benzyl viologen-nitrate reductase activity respectively of the nitrate-nonutilizing mutants nit-1 and nit-3 are not inactivated in vivo by the addition of an ammonium salt or the withdrawal of nitrate. This finding suggests that the integrity of the nitrate reductase complex is required for the in vivo inactivation of nitrate reductase and its associated activities.


Style of adaptation to aversive maternal control and paranoid behavior.


Physician assistants' training. A model for human resources development.


Degradation of lysine in chicks.

Degradation of lysine in chicks.


Starvation and refeeding: effects on the periodicity of tryptophan and tyrosine metabolism in mice.


Studies on transplantation antigen extracts in Syrian hamsters.


Effects of selection and migration on geotactic and phototactic behaviour of Drosophila. 3.


Renin induced proteinuria and the effects of adrenalectomy. II. Morphology in relation to function.


Renin induced proteinuria and the effects of adrenalectomy. I. Haemodynamic changes in relation to function.


The effects of renin and adrenalectomy on blood distribution and capillary permeability.


Photorespiration and nitrogenase activity in the blue-green alga, Anabaena cylindrica.


Address of the president, Professor A.L. Hodgkin, at the Anniversary Meeting, 30 November 1971.


Quantum content in guinea-pig serratus anterior.


Address of the President, Professor A.L. Hodgkin, at the Anniversary Meeting, 30 November 1971. Recent work on visual mechanisms.


Pitfalls in arteriography of islet-cell tumors of the pancreas.


The N-terminal amino acid sequence of sheep heart myoglobin.


Quantitative structure-activity studies of hydrazones, uncouplers of oxidative phosphorylation.


Identification of flavonoids and cinnamic acid derivatives from spinach chloroplast preparations.


Light scattering and flow dichroism studies on DNA after the photoreaction with psoralen.


On the binding of benz(a)pyrene to DNA "in vivo".


Cytochrome P-450 as a microsomal peroxidase in steroid hydroxylations.


Kinetics of atropine inhibition of histamine-stimulated gastric secretion in the dog.


A study of a patient's "re-grief work." Through dreams, psychological tests and psychoanalysis.


Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.


Insomnia: old wine in a new bottle.

Insomnia: old wine in a new bottle.


New tactics for hyperthyroidism: sympathetic blockade.


Beta adrenergic blockade and the phantom limb.


A mechanism for regulation of insulin release in hypoxia.


Resistance to beta-adrenoceptor stimulatnts.


Isoenzymes of isocitrate dehydrogenase in cytoplasm of human cancer cells.


A new microcrystal reaction for the demonstration of antihistamine in dead body material and tablets.


Contraception or abortion?

Contraception or abortion?


An unexpected result of psychosis in marriage.


Orchiopexy: a new anchoring technique, window septopexy.


Bilateral facial paralysis.

Bilateral facial paralysis.


Replantation of the foot. Results after two years.


The practice of medicine: past, present, and future.


The effect of gamma radiation and actinomycin on cortisone induction of liver enzymes.


Acid-soluble deoxynucleotides and DNA synthesis in growing yeast after x-irradiation. I. Diphenylamine positive material in synchronized and asynchronously growing cells.


On the biosynthesis of juvenile hormone in the adult Cecropia moth.


Studies on the secondary structure of intraphage T-7 DNA.


Effect of irradiation on the biosynthesis of liver ribonucleic acids in intact and adrenalectomized rats.


The significance of metabolic energy and the ion pump for the receptor potential of the crayfish photoreceptor cell.


Derivation of the photo-electric efficiency of photoreceptors and a method of extracellular measurement of nerve current. I.


The photo-electric efficiency of the median and the lateral photoreceptor of the barnacle Balanus eburneus. II.


Identity of streptolysin-O and NAD-glycohydrolase (EC 3.2.2.5).


Immunosuppressive action in vitro by a bovine spleen extract.


Studies on the recovery of X-irradiated bacteria.


On the nature of achromatic lesions ("gaps") induced by X-rays in chromosomes of Vicia faba.


Control of fatty acid and lipid biosynthesis in Euglena gracilis by ammonia, light and DCMU.


Influence of UV-light on gene-conversion in Neurospora.


Covalent binding of amino acids to proteins due to gamma irradiation.


Cells involved in cell-mediated and transplantation immunity. 3. The organ source(s) of the cells in the normal rabbit which mediate a reaction of cellular immunity in vitro.


Graft-versus-host reactions in mice. II. Antagonism between marrow and thymus cells.


Increased plaque-forming cell response to pneumococcal polysaccharide type 3-coated sheep erythrocytes after priming with erythrocytes but not with polysaccharide.


'Glue-ears'.

'Glue-ears'.


The leakage and destruction of CoA in isolated mitochondria.


Origin of epidemics of Venezuelan equine encephalitis.


Physician assistants and medical practice.


Complications of smallpox vaccination.

Complications of smallpox vaccination.


The influence of a cryptorchid milieu on the initiation of spermatogenesis in the rat.


Pathogenesis of graft-versus-host reaction. I. Influence of thymectomy and adrenalectomy on development of lymphopenia.


Immunological competence of spleen cells from rats bearing syngeneic or autochthonous tumours.


Impaired phagocytosis of pneumococcus type 3 in splenectomized rats.


An analysis of the convulsant activity of substituted benzenes in the mouse.


The in vitro metabolism of 2,4-dinitrophenol by rat liver homogenates.


The interaction between theophylline and some adrenergic  - and  -receptor agonists evaluated as effect on the LD50 of mice.


The action of practolol on the isolated rat atrium.


Asystole after verapamil.

Asystole after verapamil.


Management of traumatic injuries to teeth. (Review of the literature and case report).


Personality characteristics of adolescent users of dangerous drugs as indicated by the Minnesota Multiphasic Personality Inventory.


Tricyclic antidepressants and the vascular system.


Efficiency and effectiveness of different water cooled suits--a review.


Physician associates and assistants.

Physician associates and assistants.


Digitalis intoxication.

Digitalis intoxication.


The United States' position on environment.


Dental health program of the University of Alabama in Birmingham. IX. A summary of seven years experience.


Arthropods biting cattle during an epizootic of ephemeral fever in 1968.


Virus strains isolated from arthropods during an epizootic of bovine ephemeral fever in Queensland.


Personality variants and personality disorders.


Undescended testis.

Undescended testis.


Seminar on cancer.

Seminar on cancer.


The barefoot doctors of the People's Republic of China.


Delegation of tasks in radiology to allied health personnel. Reaction of radiologists.


Prediction of anxiety and depression patterns among coronary patients using a Markov process analysis.


Insight into the contractile actions of antihistamines on micro-vascular smooth muscle.


Flavodoxin from Azotobacter vinelandii.

Flavodoxin from Azotobacter vinelandii.


Central neural structures and pathways important for control of blood clotting: evidence for release of antiheparin factor.


Observations on the interactions between desipramine and reserpine on adrenergic transmission in the rat.


Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man.


A possible relation between pKa 1  and lipid solubility and the amounts excreted in urine of some tobacco alkaloids given to man.


Kinetics of dextrose degradation under autoclaving conditions.


The effect of sugars on the temperature dependence of the critical micelle concentrations of cationic surfactants.


The severely deformed foot in leprosy. Causation, prevention and treatment.


The preservation of ophthalmic solutions with antibacterial combinations.


The absorption from the gut of quinine and chlorpheniramine given with various anionic agents.


Prostaglandins and anti-inflammatory drugs in the dog knee joint.


Porphyrogenic activity of methsuximide and its demethylated metabolite.


Contraction of the rat isolated colon by adrenaline.


Simultaneous measurement of skeletal muscle, pulmonary mechanical and vascular responses to bronchodilators in the cat.


Effects of caffeine on central monoamine neurons.


Selective inhibition by mepacrine of the release of "rabbit aorta contracting substance" evoked by the administration of bradykinin.


Effects of phenoxybenzamine on transmitter release and effector response in the isolated portal vein.


5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid and brain of different rabbit breeds after treatment with probenecid.


Does aspirin exist in polymorphic states?


Neurotoxic effects of DDT: protection by cycloheximide.


Accumulation of amphetamine and p-chloroamphetamine into synaptosomes of rat brain.


The mechanism of oxidation of amphetamine enantiomorphs by liver microsomal preparations from different species.


A simple method for the preparation of injectables of tetrahydrocannabinols and cannabis extracts.


Inhibition of granuloma formation and prolonged survival in experimental schistosomiasis.


Physician assistants--and others--in primary health care.


Epidemiological surveillance and geographical pathology.


An innovation in mosquito-borne disease protection.


The influence of adrenolytic agents on the catecholamine toxic action in mice and rats.


Hereditary angioneurotic edema. A case with recurring abdominal pain.


Does prior antibiotic treatment hamper the diagnosis of acute bacterial meningitis? An analysis of a series of 135 childhood cases.


Glutamine synthetase. A mitochondrial enzyme in uricotelic species.


Selective inhibition of photosynthetic reactions by polycations.


The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor.


A reappraisal of the role of mosquitoes in the transmission of myxomatosis in Britain. Field experiments were made in southern England to re-examine the possibility that mosquitoes in Britain might feed on wild rabbits and hence be vectors of myxomatosis. Mosquitoes of several species were attracted to rabbits enclosed in cylindrical traps and in a trap in which the animal was placed in a wire mesh cage. Substantial numbers of mosquitoes were also caught biting, or attempting to bite, tethered rabbits which were not in cages or traps. Evidence that mosquitoes fed on wild rabbits under natural conditions was obtained from results of precipitin tests made on blood-smears collected from mosquitoes caught resting amongst vegetation. On a few evenings mosquitoes were seen to be attracted to healthy wild rabbits and apparently attempting to feed on them. Batches of two mosquito species collected from the field were infected with myxoma virus.It was concluded that contrary to previous beliefs mosquitoes in Britain feed to a certain extent on wild rabbits, and therefore are potential vectors of myxomatosis. No attempts were made to assess their relative importance in the transmission of the disease, which in Britain is transmitted mainly by the rabbit flea.


Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue.


The inhibition of phenylalanine and tyrosine hydroxylases by high oxygen levels.


Effects of surgical decentralization and nerve growth factor on the maturation of adrenergic neurons in a mouse sympathetic ganglion.


Alteration of GABA system and Purkinje cells in rat cerebellum by the convulsant 3-mercaptopropionic acid.


The effects of temperature and substrates on component reactions of the hepatic microsomal mixed-function oxidase.


An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate.


The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice.


Inhibition by colchicine and by vinblastine of acetylcholine-induced catecholamine release from the adrenal gland: an anticholinergic action, not an effect upon microtubules.


6 -amidinopenicillanic acids--a new group of antibiotics.


The carcinoid. A collective review.

The carcinoid. A collective review.


Ultrastructure of mechanoreceptors of the polyp coryne pintneri (Hydrozoa, Athecata).


Pindolol, (Visken, LB46). A new treatment for hypertension: report of a multicentric open study.


On certain correlations between the cholinolytics, the convulsive reactivity of the central nervous system, and the anticonvulsive activity of the anticonvulsants. II. Communication: cholinolytics upon corazol, strychnine, and thiosemicarbazide convulsions.


Some bronchoconstricting and bronchodilating responses of human isolated bronchi: evidence for the existence of  -adrenoceptors.


Antagonism by propranolol of the inhibitory effect of phenoxybenzamine on noradrenaline uptake in vivo.


The action of azapropazone, oxyphenbutazone and phenylbutazone on lysosomes.


Myocardial necroses produced by intravenous infusion of isoprenaline into rats.


The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release.


The excretion of hydroxyamylobarbitone in man after oral administration of amylobarbitone and hydroxyamylobarbitone.


The influence of methyl substitution on the N-demethylation and N-oxidation of normethadone in animal species.


The effect of ethanol on phenobarbitone and pentobarbitone absorption into rat blood and brain.


Determination of N-(2-benzoyloxyethyl)-norfenfluramine (JP 992) and its metabolites in urine.


Infrared identification of sulphonamides using attenuated total reflection.


Potentiation by cocaine of responses of the guinea-pig isolated tracheal chain to ethylnoradrenaline and  -methylnoradrenaline.


Effect of neuroleptics on brain amphetamine concentrations in the rat.


Cross tolerance between methylamphetamine and morphine in the mouse.


Effect of dimethyl and monomethyl tricyclic antidepressants on central 5-hydroxytryptamine processes in the frog.


The distribution of noradrenaline in the undivided spleen of the cat.


Effect of calcium on reserpine-induced catalepsy.


Diurnal variation of hepatic amphetamine concentrations in mice fed freely and fed single daily meals.


Preliminary evidence that syrosingopine produces a selective depletion of central stores of sympathomimetic amines.


Differences in the locomotor activity of mice as measured by an Animex and photoresis to actometer.


On the action of bombesin on the kidney of the rat and the dog.


Effect of eserine injected intraventricularly on behaviour and on activity of cholinesterase in some structures of the cerebral ventricles of the conscious cat.


Interaction of salicylate and cortisol on lysosomes.


Excitatory effect of tetrodotoxin on an isolated smooth muscle organ.


Evidence for a new type of dopamine receptor stimulating agent.


Reduction of histamine in mouse brain by N 1 -(DL-seryl)-N 2 -(2,3,4-trihydroxybenzyl) hydrazine and reserpine.


Prolonged effects of reserpine administration on adrenoceptor activity in dogs.


Endogenous, possibly prostaglandin-mediated inhibition of the neuromuscular transmission in the vas deferens.


On the dopamine-like action of apomorphine.


The two year associate.

The two year associate.


A monitored release study. A clinical trial of oxprenolol in general practice.


The metabolism of ethanol and its metabolic effects.


Physician assistants and others in primary health care.


The effect of  -adrenergic blockade on cardiac responses to orthostatic stress.


The respective involvement of noradrenaline and its deaminated metabolites in waking and paradoxical sleep: a neuropharmacological model.


The physician's assistant.

The physician's assistant.


Inhibition of synaptosomal protein synthesis by neurotransmitter substances.


Separation of glycogen formation and aminotransferase activity induced by cortisol in fetal rat liver.


Influence of ovariectomy and ovarian steroids on hypothalamic tyrosine hydroxylase activity in the rat.


Kinetic data on the formation of 17 -hydroxy-5 -androstan-3-one in renal nuclei from male and female rats.


Research on the outcome of social work therapeutic interventions: a review of the literature.


Correlates of the psychiatric sick role.


Taste phenomena and drug effects on thirst-induced fluid consumption by rats.


Treatment of vasomotor rhinitis with a combined antihistaminic--sympathomimetic preparation.


Participation of pediatric residents in a nurse practitioner program.


Asthma.

Asthma.


The reduction of hydroxypyruvate by human serum.


Glutamine synthetase. 8. Purification and some properties of the enzyme from rat liver.


Evidence for a  -adrenergic receptor initiating DNA synthesis in haemopoietic stem cells.


Polyarteritis nodosa diagnosed by renal arteriography.


Chronic severe hemolytic anemia due to G-6-PD Charleston: a new deficient variant.


Transfer of immune responsiveness.

Transfer of immune responsiveness.


Induction of benzo( )pyrene hydroxylase in human skin. Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[alpha]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[alpha]anthracene, a two- to fivefold increase in activity of benzo[alpha]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.


Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety. Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in the brain.


Ulcerative postdysenteric colitis.

Ulcerative postdysenteric colitis.


A stable and easily extractable plant-type ferredoxin from the blue-green alga Spirulina maxima.


Mammalian RNA polymerases I and II: independent diurnal variations in activity.


Studies on enzymes from parasitic helminths. I. Purification and physical properties of malic enzyme from the muscle tissue of Ascaris suum.


Purification and some properties of diacetyl reductase from beef liver.


Pneumococcal neuraminidase: purification and properties.


NAD glycohydrolase from the small intestine of the rat; purification, properties and possible role of the enzyme.


Enzymes in the digestive tract of two species of euryhaline fish.


Diel variation in the thermal tolerance of Litoria gracilenta (Anura: Hylidae).


Intestinal disaccharidase activity of non-human primates. I. Tupaiidae, Cebidae and Cercopithecidae.


Ion, water and urea turnover rates in the nurse shark, Ginglymostoma cirratum.


Effects of vertebrate insulins upon serum FFA and phospholipid levels in the goldfish, Carassius auratus Linnaeus.


Effect of reduced calcium on excitatory transmitter release at the crayfish neuromuscular junction.


Intestinal digestion and absorption of starch in the intact rat: effects of cestode (Hymenclepis diminuta) infection.


Molluscan hemoglobins with unusual temperature-dependent characteristics.


Observations on the histochemical "aminopeptidase" reaction in the intestine of certain species of leech (Annelida: Hirudinea), with particular reference to Erpobdella octoculata (L.).


Rate of passage of a non-absorbable marker through the gastrointestinal tract of the mouse (Mus musculus).


Mechanisms of amino acid transport in trypanosoma lewisi.


Pharmacologic studies of indoramin in man.


Absorption of some amino acids by the haemoflagellate, Trypanosoma gambiense.


Inadequacy of blood drawn by cardiac puncture as a source for respiratory gas measurements in turtle (Pseudemys scripta).


Direct evidence for a centrally-mediated hypotensive action of L-dopa in anesthetized dogs.


Possible involvement of  - and  -receptors in the natural colour change and the MSH-induced dispersion in Xenopus laevis in vivo.


Picrotoxin-like action of bicuculline.

Picrotoxin-like action of bicuculline.


Effect of some  -adrenergic blocking agents on the acetylcholine content of heart. An experimental study in mice.


Anabolic activity of buclizine on rats.

Anabolic activity of buclizine on rats.


-Sympathetic receptor stimulation in the brain and hypotensive activity of  -methyldopa.


Lack of correlation between RNA synthesis and hormonal induction of liver enzymes in carbon tetrachloride treated mice.


Elevation of blood glucose and induction of hepatic enzymes by 2-deoxyglucose in mice with hypothalamic damage caused by gold thioglucose.


Hemopoietic inductive envirnment necessary for an early stage in differentiation of thymic immune cells: effect of antilymphocytic serum.


Abnormally high serum acid phosphatase.

Abnormally high serum acid phosphatase.


Predicting emotional adjustment in home dialysis patients and their relatives.


Reducing the eyelid edema and ecchymosis that occur after corrective rhinoplasty.


The undescended testis. A clinical and histological study.


Inflammatory lymphoid cells. Cells in immunized lymph nodes that move to sites of inflammation.


Bacterial colonization profile with tracheal intubation and mechanical ventilation.


Comparison of the bronchodilatory action of two drugs.


Call for help? The demand for physician assistants in Kansas.


Potassium-induced acceleration of catecholamine biosynthesis in brain slices. I. A study of the mechanism of action.


Isolation and characterization of a tyrosine hydroxylase cofactor from bovine adrenal medulla.


Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation.


Psychometric test performance in relation to the psychopathology of epilepsy.


Beta-receptor sensitization by repeated injections of isoproterenol and by cold adaptation.


Autonomic control of heart rate in the horse.


Cardiac output at rest in the squirrel monkey: role of  -adrenergic activity.


Relation of gluconeogenesis to ammonia production in the kidney.


Brain enzymes in amantadine-treated rats.


Time course of the development of enzymes involved in the synthesis of norepinephrine in the superior cervical ganglion of the rat from birth to adult life.


In vitro progesterone synthesis by corpora lutea induced in prepuberal cattle.


Work-related dental diseases.

Work-related dental diseases.


Australia antigen and polyarteritis nodosa.


Changing patterns of susceptibility of common bacterial pathogens to antimicrobial agents.


Regulation of the enzymes of tyrosine catabolism in Tetrahymena pyriformis.


Teeth--and the anesthetist.

Teeth--and the anesthetist.


The induction of nitrite reductase in Neurospora crassa.


Bacillus subtilis glutamine synthetase. Dependence of  -glutamyltransferase activity on ionic strength and specific monovalent cations.


Regulatory properties of soluble and particulate rat brain tyrosine hydroxylase.


Relationship between sleep habits, adrenocortical activity and personality.


The action of sympatholytic drugs in experimental intestinal paralysis.


Synthesis of noradrenaline in isolated rat iris during field stimulation.


3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.


Immunochemical studies on electron transport chains involving cytochrome P-450. The role of the iron-sulfur protein, adrenodoxin, in mixed-function oxidation reactions.


The temperature dependence of the components of the hepatic microsomal mixed-function oxidases.


Carbon dioxide fixation by isolated chloroplasts of Euglena gracilis. I. Isolation of functionally intact chloroplasts and their characterization.


Cytochrome P 450K  of rat kidney cortex microsomes: its involvement in fatty acid  - and ( -1)-hydroxylation.


Structure of the light-emitting moiety of aequorin.


Carbon dioxide fixation by isolated chloroplasts of Egulena gracilis. II. Inhibition of CO 2  fixation by AMP.


31 P and  13 C nuclear magnetic resonance studies of nicotinamide-adenine dinucleotide and related compounds.


Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides.


Enzymatic degradation of heme. Oxygenative cleavage requiring cytochrome P-450.


Fatty acid biosynthesis. IX. Fatty acid synthesis from enzymically and chemically acetylated rabbit mammary gland fatty acid synthetase.


Hormonal regulation of rat mammary gland enzyme activities and metabolite patterns.


Energy metabolism of the skeletal muscle of genetically dystrophic hamster.


Cellular control of lymphocytes initiating graft vs. host reactions.


Survey of gerontologists' opinions on White House Conference on Aging issues on education and training.


Preparation of plasma membrane from isolated neurons. A bulk fraction enriched with respect to neuronal cell bodies was used as starting material for the isolation of neuronal plasma membrane The cells were gently homogenized in isotonic sucrose and a crude membrane containing fraction sedimented at 3000 g. Subsequently, the membrane fraction was purified on a discontinuous sucrose density gradient between 35% and 25 5% sucrose (w/w). Enzymatic analyses showed a 4-5-fold enrichment in plasma membrane markers, and a 10-15% contamination of mitochondrial and microsomal material. Electron micrographs of the membrane fraction confirmed the enzymatic data Fragmented membranes were found, mainly in vesicular form No ribosomes, but a few mitochondria and some multilamellar membranes were seen


Subcellular localization of the C 19 -steroid reductase activities of female rat liver.


Plasma 5 -dihydrotestosterone (17 -hydroxy-5 -androstan-3-one) in adolescent males at different stages of sexual maturation.


Influence of phenylbutazone and salicylic acid on the histamine content of rat experimental granuloma.


Graft-vs.-Host activity of thymocytes: relationship to the role of thymocytes in hemopoiesis.


An apparatus for the study of the behaviour patterns of mosquitos under the influence of insecticides.


Enzyme activities, gene function and ageing in mammals. (Review).


Australia and the asian student.

Australia and the asian student.


Undescended testis.

Undescended testis.


Filariasis survey among indigenous tribes of Palawan, Republic of the Philippines.


Evaluative research design for a health manpower innovation.


Conversion of lithocholic acid to 3-keto-5 -cholanoic and 3 ,6 -dihydroxy-5 -cholanoic acids by adult rat brain cell-free homogenates.


Ischaemic colitis.

Ischaemic colitis.


Stimulatory effect in vitro of prostaglandin E 1  on noradrenaline-induced lipolysis in subcutaneous adipose tissue from hypothyroid subjects.


Engineering involvement in the design of primary health care delivery systems, an example.


The effect of chloroquine on survival of skin allografts in rats: a preliminary report.


Dental disease in the narcotic addict.

Dental disease in the narcotic addict.


Eutrophication.

Eutrophication.


The effects of pesticides on life in fresh waters.


Suspended solids and fisheries.

Suspended solids and fisheries.


The ecology of some British rivers in relation to warm water discharges from power stations.


Artificial radioactivity in freshwater and estuarine systems.


Forecasting the effects of polluting discharges on rivers with special reference to the River Trent (summary only).


Problems in determining water quality criteria for freshwater fisheries.


Some aspects of pollution in Southampton Water.


The effect of industrial effluent from pulp and paper mills on the marine benthic environment.


Effects of the oil industry on shore life in estuaries.


Effects of warm water effluents from power stations on marine life.


Predicting the effect of pollution in estuaries.


Changes in the macromolecular structure of DNA-RNA-protein complexes induced by gel-filtration on sephadex G-25.


Effects of linolenic acid on system II and system I-associated light induced changes in absorption of chloroplasts.


Umbelliferone as indicator for pH changes in one turn-over.


Rise time of the absorption changes of chlorophyll-a I  and carotenoids in photosynthesis.


Antibodies against sulphoquinovosyl-diacyl glycerol and their reactions with chloroplasts.


An unusual case of tetanus.

An unusual case of tetanus.


Ascorbic acid and drug metabolism.

Ascorbic acid and drug metabolism.


Effects of chlorpromazine free radical on brain microsomal enzymes.


Further characterization of a reduced nicotinamide-adenine dinucleotide phosphate-dependent aldehyde reductase from bovine brain. Inhibition by phenothiazine derivatives.


New dimensions of dental care delivery reported at National Dental Health Conference.


Current status of the physician's assistant and related issues.


The use of antihistamines in asthma.

The use of antihistamines in asthma.


Scope of the problems of pediatric allergy.


Induction of tyrosine aminotransferase in HTC cells by N 6 , O 2' -dibutyryl adenosine 3', 5'-monophosphate.


Evidence for superoxide generation by NADPH-cytochrome c reductase of rat liver microsomes.


The biosynthesis of ethanolamine plasmalogens by a postmitochondrial fraction from rat brain.


Lactate dehydrogenases in Oomycetes.

Lactate dehydrogenases in Oomycetes.


Clinical implications of blood pressure changes during ECT.


Pathogenesis of graft-versus-host reaction. II. Influence of thymectomy and adrenalectomy on lymphoid tissue pathology; delineation of nonthymus-dependent lymphoid elements.


Cerebrospinal fluid pH and respiratory rate in bacterial meningitis.


Liver microsomes demethylation of mestranol (3-methoxy-17-ethynyl-1,3,5(10)-estratrien-17 -ol) and some of its effects on drug metabolism.


Electron microscopy of tissue culture cells infected with myxoviruses. II. Nucleo-cytoplasmic changes in fowl plague virus-infected cells.


Synthesis of tumour antigen and changes in activities of glycolytic enzymes induced by polyoma virus.


Some physico-chemical properties of Australia antigen: polyacrylamide and agarose gel electrophoresis, adsorption and specific precipitation.


Effect of cyclophosphamide on the protective action of endotoxin in mice challenged with encephalomyocarditis virus.


Hormone pretreatment and interferon production in mice.


Enhancement of interferon production by lowered temperature and-or cyclohexximide in endotoxin-stimulated mouse leukocytes.


Phytohaemagglutinin unresponsiveness in leukopenia induced by Junin virus in guinea pigs.


Production of endogenous pyrogen after interaction of different rabbit blood leukocyte types with Newcastle disease virus or endotoxin.


Studies on arbovirus haemagglutinin: differential inhibition of haemagglutinin formation by 6-azauridine and uridine kinase-containing cell-free extract.


Experimental infection of rhesus monkeys with Coxsackie A 4 virus.


Agglutination of African rodent and primate erythrocytes by arboviruses and the susceptibility of some of these animals to yellow fever and Kadam viruses.


Yaba 1 virus in Czechoslovakia. I. Some physical and chemical properties of yaba 1 (Lednice 110) virus.


Episcleral nodule in systemic vasculitis.


Effects of prostaglandin A 1  on left ventricular dynamics in the conscious dog.


Factorial structure and MMPI correlates of a fear survey schedule in a clinical population.


The antagonism of the glutamate-induced and synaptic excitations of thalamic neurones.


Intracellular studies on the action of L-glutamic acid on spinal neurones of the cat.


The law and the physicians assistant.

The law and the physicians assistant.


The need for a health worker to assist the physician.


The future expanded role of the nurse.

The future expanded role of the nurse.