The biochemical, physiological, and metabolic evaluation of human subjects in a life support systems evaluator and on a diet of precooked freeze dehydrates foods. AMRL-TR-67-12.


Subcritical liquid oxygen storage and supply system for use in weightless environments. AMRL-TR-66-178.


Investigation of an integrated carbon dioxide-reduction and water-electrolysis system. AMRL-TDR-66-186.


Integrated life support system study. (20-day evaluation program). AMRL-TR-66-185.


Development of the firefly bioluminescent assay for the rapid, quantitative detection of microbial contamination of water. AMRL-TR-67-71.


Research on oxygen toxicity at the cellular level. AMRL-TR-66-206.


Interchange of group C beta hemolytic Streptococci among dogs and monkeys confined in dynamic flow atmospheric systems. AMRL-TR-66-182.


Microbiological criteria for aerospace potable water systems. AMRL-TR-67-37.


Degradation and activation of parathion analogs by microsomal enzymes.


Metabolism in vitro of warfarin by enzymic and nonenzymic systems.


Metabolism of serotonin by the isolated perfused rat liver--effect of glucuronyl transferase deficiency or monoamine oxidase inhibition.


The metabolism of D- and L-lysine in the intact rat, perfused liver and liver mitochondria.


The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant.


Separation of soluble mouse liver 21-desoxy-20-alpha-hydroxysteroid: NADP 20-alpha-oxidoreductase from 21-hydroxy-20-alpha-hydroxysteroid: NADP 20-alpha-oxidoreductase.


Some energy-producing systems in Bdellovibrio bacteriovorus, strain 6-5-S.


A quantum-biological analysis of thiazide diuretics and ethacrynic acid.


Prevention of dental caries. 3. Clinical trial of calcium sucrose phosphates as a food additive.


Semiquinone of D-amino acid oxidase.

Semiquinone of D-amino acid oxidase.


Light induced proton gradient links electron transport and phosphorylation.


Control of the discharge of cnidae in Diadumene luciae (Verrill).


Application of cell culture as a primary toxicity screen of possible spacecraft contaminants. NASA TN D-4251.


Effects of physostigmine on electrical activity of the cat brain.


The microbiological flora of the Gemini IX spacecraft before and after flight. NASA CR-972.


Engineering criteria for spacecraft cabin atmosphere selection. NASA CR-891.


An international recommendation for quantities and units in clinical chemistry.


Rapidly progressive (nonstreptococcal) glomerulonephritis.


Central nervous system actions of some phenothiazine derivatives.


The chemistry of the brain.

The chemistry of the brain.


Failure of brain norepinephrine depletion to extinguish the daily rhythm in hepatic tyrosine transaminase activity.


Effect of radiation on meiotic systems.

Effect of radiation on meiotic systems.


Embryotoxic effects of antihistamines.

Embryotoxic effects of antihistamines.


The basic processes of schizophrenia.

The basic processes of schizophrenia.


Systematic oscillations in metabolic functions in liver from rats adapted to controlled feeding schedules.


Defining schizophrenia with the techniques of molecular biology.


New corticoid 3-(2'-chloroethoxy)-6-formyl-9-alpha-fluoro-delta-3,5-pregnadien derivatives in experimental allergy.


Specificity of beta-receptor antagonists.


Regular physical activity and the cardiac patient.


Lincomycin: a clinical study.

Lincomycin: a clinical study.


Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes. II. Microbiological and pharmacological studies.


Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes. IV. Biochemical mechanism of action of substance B 44 P.


Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes. 3. Chemotherapeutic effect on staphylococcal infection in mice.


Relationship of nutritional and hormonal influences on liver enzyme activity.


Effect of drugs on luminescence in larval fireflies.


The effect of experimental cryptorchism on the isozymes of lactate dehydrogenase in mouse testes.


Testicular lipids. 3. Effect of surgery and unilateral or bilateral cryptorchidism.


Urometric studies on the function of the upper urinary tract.


The effect of isopropylamino radical on the cardiovascular system.


Experimental host-parasite relationship studies with Oesophagostomum columbianum in sheep. II. Some effects of subcutaneous infections upon host immune and hypersensitive responses.


Cutaneous periarteritis nodosa.

Cutaneous periarteritis nodosa.


Idiopathic lipogranulomatous hypodermitis.


The molecular weight and some kinetic properties of crystalline rat liver glutamate dehydrogenase.


Interaction between growth hormone and cortisol on the regulation of liver tyrosine transaminase activity.


Biochemical similarities between hypothyroidism and riboflavin deficiency.


Effects of iodotyrosines on basal and stimulated glucose oxidation and phospholipogenesis in sheep thyroid slices.


Quantitative histological distribution of isocitric dehydrogenase in the rat adrenal with effects of adrenocorticotropin, and determination of the enzyme in microgram samples of tissue.


Synergism between respiratory viruses and bacteria.


Pyridine nucleotides in renal ammonia metabolism.


Enzyme pattern and aerobic growth of Saccharomyces cerevisiae under various degrees of glucose limitation. The enzyme pattern of Saccharomyces cerevisiae was followed during batch growth and in continuous culture in a synthetic medium limited for glucose under aerobic conditions. Seven enzymes were measured: succinate-cytochrome c oxidoreductase, malate dehydrogenase, nicotinamide adenine dinucleotide-linked glutamate dehydrogenase, malate synthase, isocitrate lyase, aldolase, and nicotinamide adenine dinucleotide phosphate (NADP(+))-linked glutamate dehydrogenase. During fermentation of glucose and high growth rate (mu) during the first log phase in batch experiments, the first five enzymes (group I) were repressed, and aldolase and NADP(+)-linked glutamate dehydrogenase (group II) were derepressed. During growth on the accumulated ethyl alcohol and lower mu, the group I enzymes were preferentially formed and the other two were repressed. A sequence of derepression of the group I enzymes was found during the shift from glucose to ethyl alcohol metabolism, which can be correlated with a strong increase in the percentage of single (nonbudding) cells in the population. A correlation between the state of cells in the budding cycle and enzyme repression and derepression is suggested. In continuous culture, the enzyme pattern was shown to be related to the growth rate. The group I enzymes were repressed at high growth rates, while the group II enzymes were derepressed. Each enzyme exhibits a different dependence. The enzyme pattern is shown to depend on the rate of substrate consumption as well as on the type of metabolism and to be correlated with the budding cycle. The enzyme pattern is considered to be controlled by changes of intracellular catabolic or metabolic conditions inherent in the division cycle.


Work schedules and performance during confinement.


Progress in the chemotherapy of leprosy as reflected in the International Congresses.


Enduracidin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity.


A trial of thioproperazine (Majeptil) in schizophrenia.


Regulation of NAD biosynthesis via the pyridine nucleotide cycle.


NAD synthesis in animal tissues.

NAD synthesis in animal tissues.


Enzymatic cleavage of the cholesterol side chain to dehydroepiandrosterone and 2-methylheptan-6-one.


Alpha adrenergic blocking and antispasmodic properties of SU-12080, 1-[3-ethoxy-3-(p-tolyl)-propyl]-4-(o-tolyl)-piperazine dihydrochloride.


An autoradiographic study of genetic transformation.


Synaptic transmission.

Synaptic transmission.


The cnidoblast-musculoepithelial cell complex in the tentacles of hydra.


The importance which OIE attaches to the studies of epizootiology, diagnosis, and control of bovine leukosis.


Controlled hypotension.

Controlled hypotension.


Pharmacological properties of the postsynaptic inhibition by Purkinje cell axons and the action of gamma-aminobutyric acid on deiters NEURONES.


Zollinger-Ellison syndrome. An analysis of twenty-five cases.


On the accumulation of 35S-chlorpromazine in the adrenal gland.


Insulin secretion from toadfish islet tissue stimulated by pyridine nucleotides. The addition of glucose stimulated release of insulin from the isolated islet tissue of the toadfish incubated in vitro. Reduced nicotinamide-adenine dinucleotide also stimulated insulin release, whereas the oxidized form had no effect. Both oxidized and reduced nicotinamide-adenine dinucleatide phosphate stimulated insulin release, but the reduced form was significantly more effective.


Effect on N-hydroxyethylpromethazine (Aprobit) on the distribution of 35S-chlorpromazine studied by autoradiography in cats and mice.


Dedicated duo dispatches daily deadlines.


Workmen's Compensation Board report.

Workmen's Compensation Board report.


Student Conference on Dental Research.

Student Conference on Dental Research.


The Dental Students Conference on Research, 1968.


Some statistical aspects of a clinical study on dental caries in children.


The change in clinical DMFT scores of Kansas City school children over a ten year period.


A radon removal system for the NASA lunar sample laboratory: design and discussion. ANL-7360.


Quantitative histochemistry of nicotinamide adenine nucleotides in retina of monkey and rabbit.


A review of the Navy chamber fire safety program. EMD-TR-67-2.


Hazards assessment and protective clothing requirements. EMD-TR-67-2.


Further studies on the problems of fire in artificial gas environments. EMD-TR-67-2.


Combustion safety in diving atmospheres. EMD-TR-67-2.


Fire protection for oxygen enriched atmosphere applications. AMD-TR-67-2.


Fire extinguishment and protective clothing evaluations. AMD-TR-67-2.


Binding of chlorpromazine and thioproperazine in vitro. II. Fluorometric measurement of stoichiometry and alteration of protein structure.


Methods of administrative control for the promotion of quality in dental programs.


A computer program for personality analysis.


The effects of some beta-adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart. 1. The potencies of some beta-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blocking uptake and release of noradrenaline, although none was at potent as cocaine; MJ 1999 and I.C.I. 50172 were only weakly effective.3. Pronethalol and dichloroisoprenaline each reduced release of noradrenaline by tyramine in the concentration range (10(-7)-10(-6)M) where blockade of responses to tyramine was apparent; with these drugs both reduction of noradrenaline release and beta-receptor blockade contribute to the reduction in responses to tyramine.4. Potency of beta-receptor blocking drugs in reducing noradrenaline uptake is unrelated to potency in blocking beta-receptors; Kö 592 blocks beta-receptors without affecting noradrenaline uptake.


5-Hydroxytryptamine metabolism in rat brain and liver homogenates. 1. The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities.2. In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD(+) to a greater extent than by NADP(+).3. In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH.4. In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.


Interactions between acetylcholine, 5-hydroxytryptamine, nicotine and morphine on isolated rabbit atria. 1. The effects of 5-hydroxytryptamine (5-HT) and morphine on the responses to acetylcholine and nicotine of isolated rabbit atria were studied.2. 5-Hydroxytryptamine (10 mug/ml.) and morphine (20 mug/ml.) blocked the negative chronotropic and inotropic actions of acetylcholine.3. Nicotine (20 mug/ml.) produced stimulation of the atria, which was blocked by dichlorisoprenaline, morphine, 5-HT, bretylium and hemicholinium. Hemicholinium block was reversed by choline.4. In reserpinized preparations, nicotine produced inhibition of atria and this action was also blocked by atropine, 5-HT and morphine. Inhibition induced by nicotine was potentiated by physostigmine.5. 5-Hydroxytryptamine (20 mug/ml.) produced stimulation of atria. This was blocked by bretylium and reduced by hemicholinium. Hemicholinium block was reversed by choline.6. It is concluded that 5-HT in low concentrations acts as a weak agonist at the cholinoceptive receptors and therefore blocks the action of acetylcholine. Furthermore, nicotine and larger doses of 5-HT have actions on ganglionic structures and liberate acetylcholine, which in turn releases catecholamines.


Viral infections of the nervous system.

Viral infections of the nervous system.


Problems in the evaluation of the optimal dose of a phenothiazine (butaperazine).


Cytochrome P450 and steroid 11beta-hydroxylation in mitochondria from human adrenal cortex.


Effects of the NN'-triethyl analogue of suxamethonium on neuromuscular transmission.


The uptake and retention of [3H]noradrenaline in rat sciatic nerves after ligation.


Release of oxytocin contributes to the natriuretic action of aminophylline in rats.


The effects of drugs on circular muscle strips from the isolated ileum of the rabbit.


The partially inhibited growth of Escherichia coli in the presence of some antibacterial agents.


The determination of bupivacaine, lignocaine and mepivacaine in human blood.


The solubilities of the lower testosterone esters.


A note on insulin tolerance during mebanazine treatment.


Peptic inhibition by macroanions.

Peptic inhibition by macroanions.


The penetration of catechol and pyrogallol into mouse brain and the effect on cerebral monoamine levels.


The effect of electroconvulsive shock on the cerebral metabolism of dopamine and 5-hydroxytryptamine.


The influence of cardiac glycosides on membrane permeability in guinea-pig atrial tissue, determined by means of 86Rb.


Effects of some spasmolytic agents on the lipid-facilitated transport of calcium ions.


A new peripheral and coronary vasodilator substance of the beta-aminoketone group.


Enhancement by heated rabbit-serum of antihistamine activity.


Automated spectrophotometric assay of serum lactic dehydrogenase and hydroxybutyric dehydrogenase with clinical evaluation.


Effect of duration of experimental cryptorchidism on testis composition and metabolic activity.


Effect of hyper- and hypoglycemia accompanying cryptrchidism on testis function.


Urinary rentention from Ornade.

Urinary rentention from Ornade.


Studies on "intrinsic" allergic respiratory disease, with a hypothesis concerning its pathogenesis.


Some basic principles of psychochemotherapy.


The metabolic fate of the products of citrate cleavage. Adenosine triphosphate-citrate lyase and nicotinamide-adenine dinucleotide phosphate-linked malate dehydrogenase in foetal and adult liver from ruminants and non-ruminants. 1. Foetal rat liver slices incorporate the C-3 of aspartate and C-2 of glutamate into fatty acids at rates equal to those observed with adult rat liver slices. Incorporation of either of these labelled carbon atoms into fatty acids would require a functioning citrate-cleavage pathway which consists of the enzymes ATP-citrate lyase, NAD-malate dehydrogenase and NADP-malate dehydrogenase. However, NADP-malate dehydrogenase is present in foetal rat liver at only 5% of the activity detectable in adult rat liver. 2. From these findings and the effect of cofactors on the formation of (14)CO(2) from [1,5-(14)C(2)]citrate in liver supernatant fractions (100000g), it is suggested that NADP-malate dehydrogenase limits the citrate-cleavage sequence. 3. Measurement of the citrate-cleavage pathway by incorporation studies with [3-(14)C]aspartate and [U-(14)C]glucose and by determining the activities of ATP-citrate lyase and NADP-malate dehydrogenase have shown that this sequence of reactions is present in the liver of the bovine foetus but not in the adult. However, C-2 of glutamate is not incorporated into fatty acids or non-saponifiable lipid by bovine liver slices. This finding as well as those presented above for the adult and foetal rat liver are interpreted on the basis of a competition between phosphoenolpyruvate carboxykinase and NAD-malate dehydrogenase for oxaloacetate produced by the cleavage of citrate in the cytosol.


Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes. I. Production, extraction and characteristics of substance B 44 P and the identity of the substance with streptovarcin.


Conceptual measurement as a mean of assessing therapeutic changes in schizophrenia.


Prevention of the ethanol-induced fatty liver by chlorcyclizine-induced maintenance of hepatic lipid oxidation.


Use of psychotropic drugs by U.S. adults.


Magnesium pemoline: stimulant effects on performance of fatigued men.


Application of radioisotopes for aerospace waste reclamation and water systems. AMRL-TR-67-158.


Beta-adrenergic receptor blocking drugs in the treatment of cardiac arrhythmias.


The potential hazard of Staphylococci and Micrococci to human subjects in a life support systems evaluator while on a simulated GT-7 mission. AMRL-TR-67-45.


Automatic water recovery system. AMRL-TR-67-155.


The potential hazard of Staphylococci and Micrococci to human subjects in a life support systems evaluator and on a diet of precooked freeze dehydrated foods. AMRL-TR-67-18.


Water-electrolysis cells using hydrogen-diffusion cathodes. AMRL-TR-67-65.


Pressure sealing closures for full pressure protective suit assemblies. AMRL-TR-67-59.


A descriptive model for determining optimal human performance in systems. Volume 3. An approach for determining the optimal role of man and allocation of functions in an aerospace system (including technical data appendices). NASA CR-878.


A study of the performance of an astronaut during ingress and egress maneuvers through airlocks and passageways. NASA CR-971.


Study of methods for chemical synthesis of edible fatty acids and lipids. Final technical report. Contract Rep. NASA CR-1105.


Preliminary study of advanced life-support technology for a Mars surface module. NASA CR-1083.


Analysis of self-locomotive performance of lunar explorers based on experimental reduced-gravity studies. NASA TN D-3934.


Automatic control of water cooling in space suits. Contract Rep. NASA CR-1085.


Frankenfeld JW: Study of methods for chemical synthesis of edible fatty acids and lipids. Final summary. Contract Rep. NASA CR-1104.


Consideration for the Martians.

Consideration for the Martians.


Suicide among physician-patients.

Suicide among physician-patients.


Seven symptom profiles.

Seven symptom profiles.


Tremorgenic toxin from Penicillium cyclopium grown on food materials.


Multiple forms of bacterial NADP-specific isocitrate dehydrogenase. Electrophoretically distinct forms of nicotinamide adenine dinucleotide phosphate-specific isocritrate dehydrogenase have been observed in extracts of Escherichia coli grown under different culture conditions. In glucose-grown cells, two distinct bands of isocitrate dehydrogenase activity were observed on polyacrylamide gels and have been completely resolved by employing ion-exchange chromatography. These multiple forms of the enzyme have been studied and their possible metabolic role is discussed.


Prognostic factors in the common testis tumors.


Localized aneurysms of the coronary arteries.


Requirement of NADPH and molecular oxygen for the side-chain cleavage of 20-alpha, 22-xi-dihydroxycholesterol.


Studies on the metabolic effects of borate. VI. Effects of borate on the reduction of methemoglobin.


On the healing properties of esters of D-panthenol with terpene acids, with particular reference to D-pantothenyl trifarnesylacetate.


Polymer-drug interacted systems in the physicochemical design of pharmaceutical dosage forms. I. Drug salts with PVM-MA and with a PVM-MA hemi-ester.


The specific capsular polysaccharide of type VII Pneumococcus.


Successful surgical treatment of massive abdominal hemorrhage due to periarteritis nodosa.


Pronethalol-induced ultra-low frequency ballistocardiographic alterations in a patient with angina pectoris.


Analysis of growth factor gradients in hydra.


Biochemical and behavioral effects of magnesium pemoline.


An evaluation of a true glucose procedure utilizing the enzyme hexokinase.


The neurological complications of vaccination against smallpox and measles.


Some histochemical and biochemical ovservations on the lymphatic tissues of highly inbred white leghorns.


Radiology in locomotor disorders.

Radiology in locomotor disorders.


Testicular tumors.

Testicular tumors.


Inactivation of insecticides by bacteria isolated from polluted waters where the mosquito larva bred in large number.


Observations on the survival rate of Armigeres subalbatus after being fed on hosts with different levels of micro-filariae of Brugia pahangi.


Perceptual space and the law of conservation of perceptual information.


The intermediary role of a 19-oxoandrogen in the biosynthesis of oestrogen.


Reduced nicotinamide-adenine dinucleotide phosphate oxidase in the autotrophic blue-green algae Anabaena variabilis.


Electroshock-induced retrograde amnesia and brain serotonin metabolism: effects of several antidepressant compounds.


Effects of sympathetic and parasympathetic blocking agents on the circulation of normal and bled rats.


Prevention and remission by adrenocortical steriods of nicotinamide deficiency disease. II. A study of the mechanism.


Intramitochondrial localization of the nicotinamide adenien dinucleotide- and nicotinamide adenine dinucleotide phosphate-dependent zylitol dehydrogenases.


Studies on the mechanism of purine nucleotide inhibition of a triphosphopyridine nucleotide-specific isocitrate dehydrogenase.


Peroxisomes from spinach leaves containing enzymes related to glycolate metabolism.


Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes.


Beta-adrenergic blocking agents. 3. The optical isomers of pronethalol, propranolol, and several related compounds.


Inhibition by anions of dinitrophenol-induced ATPase of mitochondria.


Androgen biosynthesis. I. Enzymatic cleavage of the cholesterol side-chain to dehydroepiandrosterone and 2-methylheptan-6-one.


Fatty acid synthesis by chain elongation in rat-liver mitochondria.


Effect of sodium concentration on the vasoconstrictor action of angiotensin in the rabbit ear.


Kinetic studies of pigeon liver NAD kinase.


A study of the antiarrhythmic and anticonvulsant activity of three new antihistamines.


Bronchoconstrictor effect of endotoxin in guinea-pig; the protective effect of antihistamine and anti-inflammatory compounds.


Preliminary report of a trial of a long acting antihistaminic, buclizine hydrochloride in patients with bleeding after insertion of an intrauterine device.


Central hypotensive effect of alpha-methyldopa.


Polymorphism of cephaloridine.

Polymorphism of cephaloridine.


The use of the Coulter Counter for the particle size analysis of some emulsion systems.


The influence of emulsifer concentration on the rheological properites of an oil-in-water emulsion stabilized by an anionic soap.


The use of supports in the lyophilization of oil-in-water emulsions.


Pharmacological studies of a new antitussive, 4-phenyl-l-piperidinecarboxamide (AH 1932).


Protection by ethanol against the toxic effects of monofluorethanol and monochloroethanol.


Anethole and fenchone in the developing fruits of Foeniculum vulgare Mill.


On the specificity of the reversal of reserpine hypothermia for the evaluation of antiderpressant effect.


N-(3-benzythio-2,6-dichlorophenyl)anthramyl acid (ASD 30): a non-competitive antagonist of bradykinin.


Acetylcholine release from the feline thalamus.


Inhibition of red cell agglutination in the ABO system by promethazine.


Gas-liquid chromatography of imidazoline salts.


Potentiation of methamphetamine aggregate toxicity in mice by diethyldithiocarbomate.


Crystallization in polyhedral emulsion particles.


Programmed kinetic studies.

Programmed kinetic studies.


Effects of reserpine on the plasma half-time of [131-I]thyroxine.


Modified method for the estimation of metaraminol and alpha-methyl-m-tyramine.


Effect of HC-3 on choline uptake by the isolated diaphragm.


The effect of theophylline on chloride permeability and active chloride transport in various epithelia.


Adrenergic receptors in the ruminal wall of sheep.


Subcellular distribution of [3H]amphetamine and [3H]guanethidine and their interaction with adrenergic neurons.


Activity of centrally acting drugs on amphetamine metabolism.


The effects of diethyldithiocarbamate and L-dopa on body temperature in mice.


Propranolol uptake into the central nervous system and the effect on rat behaviour and amine metabolism.


The role of the tissues and gut flora in the metabolism of [14C]homoprotocatechuic acid in the rat and rabbit.


The role of the tissues and gut micro-organisms in the metabolism of [14C]protocatechuic acid in the rat. Aromatic dehydroxylation.


The effect of storage conditions on the heat resistance and heat activation response of Bacillus stearothermophilus spores.


Dissolution and crystal growth in aqueous suspensions of cortisone acetate.


The constituents of the seeds of Asphodelus microcarpus viviani and A. fistulosus L.


Effect of crystal form, cortisone alcohol and agitation on crystal growth of cortisone acetate in aqueous suspensions.


Effects of amphotericin B and phospholipase C on the uptake of catecholamines.


Behavioural effects of alpha-methyltyrosine administered in the diets of mice pretreated with a monoamine oxidase inhibitor.


The tensile strength of lactose tablets.


A note on a simple estimation of amphetamine, methylamphetamine and ephedrine in horse urine.


Determination of methylimidazoleacetic acids in human urine by gas chromatography.


Iron carbohydrate complexes.

Iron carbohydrate complexes.


Effect of two non-steroidal anti-inflammatory agents on alkaline and acid phosphatases of inflamed tissue.


The mechanism of electrocardiographic changes in thyrotoxicosis.


Studies on a biological and a chemical method of controlling the dark rice field mosquito in Louisiana.


Ego-resiliency, ego-control, and smoking cessation.


The color pyramid test: a critical evaluation.


Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2.


Various specificities of the DNA dependent RNA Polymerase for synthetic templates.


The epicuticle of millipedes belonging to the genera Cingalobolus and Aulacobolus with special reference to seasonal variations.


Reactivation of heat inactivated reovirus.


Are large doses of intravenous barbiturates justified for use as premedication in labor?


Primary pulmonary sporotrichosis in Illinois. A case report. First epidemiological link to spagnum moss.


An outbreak of histoplasmosis in Illinois associated with starlings.


Medical progress in the use of drugs in pregnancy.


Hernia of the esophageal hiatus in infants.


122 years of aesculapian.

122 years of aesculapian.


Blunt abdominal trauma.

Blunt abdominal trauma.


Surgery in infertility.

Surgery in infertility.


Comprehensive health planning in Illinois.


The effects of drug-induced adrenocortical deficiency and of mineralocorticoid drugs on anaphylaxis in the guinea-pig.


The colloidal properties of chlorhexidine and its interaction with some macromolecules.


The effect of the concentration of the water-soluble component on the rheology of some oil-in-water emulsions containing long-chain alcohols.


The effect of electrolytes on rigidity and diffusion in gelatin--glycerin gels.


Gelatin coacervate microcapsules containing sulphamerazine: their preparation and the in vitro release of the drug.


Aspects of the epimerization of certain tetracycline derivatives.


Influence of 1-(5-methyl-1-phenylpyrazol-4-yl)-3-[4-(o-tolyl)piperazin-1-yl]-propan-1-one hydrochloride (CIBA 1002-Go) on the stores of catecholamine in rat and cat tissues.


Interactions of narcotic antagonists and antagonist-analgesics.


Hypoglycaemic activity of 1,1'-biadamantylaryl sulphonylureas.


Interaction of aspirin with nonsteroidal anti-inflammatory drugs in rats.


Species differences in the plasma protein binding of desipramine.


The dual mode of action of histamine in the cat isolated tracheal chain.


An interaction between desipramine and phenylbutazone.


Guanethidine and carbachol on the isolated frog rectus: a non-competitive interaction.


Drug-induced rhythmicity in smooth muscle.


The effect of diethyldithiocarbamate on brain amine levels in the rabbit.


The binding of imipramine to the outer membrane of blood platelets.


Beta-blocking agents on the pupil of the frog.


Enhanced toxicity of imipramine and desipramine in aggregated mice.


Steric aspects of adrenergic drugs. XI. Interactions of dibenamine and beta adrenergic blockers.


Pattern of renal vasoconstriction and transmitter release during sympathetic stimulation in presence of angiotensin and cocaine.


Effects of vagal and sympathetic nerve stimulation on the isolated atria of the cat.


Serum cholesterol levels in the medical community.


Cryptorchidism.

Cryptorchidism.


An exercise in radiologic-pathologic correlation.


Reaction of Japanese encephalitis virus with mannan.


Studies on the virulence of tick-borne encephalitis virus. IX. Intranasal infection of Macaca mulatta monkeys with genetically defined virus clones.


Peculiarities of the interaction oc viruses with macrophage cultures.


Investigations on the effect of the host on certain activities of influenza virus.


Effect of lipids on the infectivity of ribonucleic acid extracted from Ranikhet disease virus.


Electron microscopy of Coxiella burneti phase I and II.


Appearance of antigens in tissue culture cells inoculated with filterable particles of Coxiella burneti as revealed by fluorescent antibodies.


Virological and cytogenetic studies on the involvement of bone marrow of mice in some hepatoencephalotropic viral infections.


Antiviral effect of methylglyoxal-bis-guanylhydrazone.


The role of birds in the circulation of tick-borne encephalitis virus in the Tribec region.


Deoxyribonuclease residues in preparations of phages and phage DNA.


Virological and clinical observations on chimpanzees exposed to Tahyna virus aerosol.


Poteplí - Uukuniemi virus isolated from Ixodes ricinus ticks in Slovakia.


Alteration in the magnitude of induction of tyrosine transaminase by glycocorticoids. The effects of phenobarbital, o,p'DDD and beta-diethylaminoethyl diphenylpropylacetate (SKF 525A).


Chemistry of the streptovaricins. V. Structures of streptovaricins A and C.


Synthesis of [1-Isoleucine-, 3-proline-, and 5-alanine]-angiotensins. II.


The euphoria of smoking.

The euphoria of smoking.


An NADP-dependent L-glutamate dehydrogenase from chloroplasts of Vicia faba L.


Zn-coproporphyrin catalyzed photoreduction of spinach ferredoxin.


Fatigue: its physiological and psychological significance.


Emotional factors in oral contraception.


Inhibition of flavoenzymes by phenothiazines.


Epithelial conduction in hydromedusae.

Epithelial conduction in hydromedusae. Sarsia, Euphysa, and other hydromedusae have been studied by electrophysiological techniques and are found to have nonnervous conducting epithelia resembling those described earlier for siphonophores. Simple, non-muscular epithelia fire singly or repetitively following brief electrical stimuli. The pulses recorded with suction electrodes are biphasic, initially positive, and show amplitudes of 0.75-2.0 mv, durations of 5-15 msec, and velocities of 15-35 cm/sec with short refractory periods. In the swimming muscle (myoepithelium) 2.0-4.0 mv composite events lasting 150-300 msec are associated with contraction waves. Propagation in nonnervous epithelia is typically all-or-none, nondecremental, and unpolarized. The subumbrellar endoderm lamella conducts independently of the adjacent ectoderm. The lower regions of the tentacles do not show propagated epithelial events. The spread of excitation in conducting epithelia and associated effector responses are described. Examples are given of interaction between events seemingly conducted in the nervous system and those in nonnervous epithelia. Either system may excite the other. Spontaneous activity, however, appears to originate in the nervous system. Conduction in nonnervous tissues is unaffected by excess Mg(++) in concentrations suppressing presumed nervous activity, although this may not be a wholly adequate criterion for distinguishing components of the two systems. Evidence from old work by Romanes is considered in the light of these findings and the general significance of epithelial conduction is discussed.


Correlates of heterosexual somatic preference.


Quantified LSD effects on ego strength.

Quantified LSD effects on ego strength.


Gramicidin induced ion transport in brain mitochondria preparations.


Tremor induced by tremorine (1,4-dipyrrolidino but-2-yne) and its antagonism by certain antihistaminics.


The role of corticosterone and 11-dehydrocorticosterone in the biosynthesis of aldosterone.


Absence of NADH:NAD+ oxidoreductase activity in mitochondrial NAD(P) transhydrogenase.


Characterisation of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver.


Plasma androgens and 17-hydroxycorticosteroids throughout the day in submarine personnel.


The oxygen requirement of an NADH dehydrogenase from Sepia officinalis.


Effect of magnesium pemoline on the survival of mice with Ehrlich ascites tumor.


Chronic dacryocystitis. A clinico-bacteriological study.


Dilaceration and transposition.

Dilaceration and transposition.


The specific substance from Pneumococcus type 34 (41). The phosphodiester linkages. 1. The phosphate groups in the type-specific substance S.34 from Pneumococcus type 34 (U.S. type 41) were shown to join the hydroxyl group at position 1 or 5 of ribitol and the hydroxyl group at position 3 of a d-galactofuranosyl residue in the next repeating unit. 2. A partial structure of the type-specific substance was derived. 3. New syntheses of d-galactose 2-phosphate and d-galactose 3-phosphate are described.


The effect of dietary fat on lipogenic enzymes in the liver of the domestic fowl.


Oxidation of [6-14C] glucose to 14CO2 by the pentose cycle in Ehrlich ascites tumor cells.


Adaptive response of tryptophan pyrrolase and tyrosine transaminase in rat liver after partial hepatectomy and laparotomy.


Acetyl-CoA synthetase, NADP malate dehydrogenase and ATP citrate lyase in the degenerating peripheral nerve.


Presynaptic recording in excised sympathetic ganglion of the rat.


Arteriography in polyarteritis nodosa.

Arteriography in polyarteritis nodosa.


Ultrastructural evidence for division of cnidoblasts in hydra.


Differential effects of ward settings on psychiatric patients. A replication and extension.


Clinical evaluation of pemoline and magnesium hydroxide as a mild stimulant in geriatric patients.


Clinicopathological conference. Renal failure without obvious cause.


Observations of the Ultrastructure of Various Borrelia species (blood and tissue forms).


Plasmodium gallinaceum as antigen in immunofluorescence antibody studies.


The breeding biology of the fruit bat Rousettus aegyptiacus E. Geoffroy living at o degrees 22'S.


Epidemiology in Papua-New Guinea. I. Dental caries.


The comparative histochemistry of some hydrolytic and oxidative enzymes in the livers of several domestic and laboratory animals.


The failure of diphenylhydantoin to influence the beta-adrenergic receptor of the heart.


Carotid sinus responses in conscious intact and adrenalectomized dogs.


Influence of substrate in the inhibition of rat liver and brain monoamine oxidase.


Studies with tiemonium iodide. An antispasmodic drug.


A comparison of the ganglionic stimulating and blocking properties of some nicotinic drugs.


On the use of discriminatory analysis for constructing strata in clinical caries increment studies.


Screeing juvenile delinquents for psychopathology by use of the Z-test.


Differential responses of addicts and non-addicts on the MMPI.


Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers. The pacemaker potential in Purkinje fibers is generated by a slow fall in potassium current which allows the inward background currents to depolarize the membrane. Adrenaline shifts the relation between activation of the potassium current and membrane potential in a depolarizing direction. Consequently, during the pacemaker potential, the potassium current falls more rapidly to lower values and the inward currents then depolarize the membrane more quickly. The shift in the potassium activation curve produced by adrenaline is large compared to that produced by calcium ions. The molecular action of adrenaline may involve either a large change in the surface charge of the membrane or a change in the dependence of the potassium permeability on the local electric field.


Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.


Familial relationships of allusive thinking in university students and their parents.


Suppression of the daily rhythm in tyrosine transaminase activity by acute elevation of norepinephrine.


Supersensitivity and dependence.

Supersensitivity and dependence.


Psychiatrists as servants of government--problems and prospects.


Effect of extent of temporal lobe surgery and neuropathology on the MMPI.


MMPI two-point code-type correlates in a state hospital population.


Characteristics of patients with hallucinations.


Clinical normative data for MMPI special scales: critical items, manifest anxiety, and repression-sensitization.


Utility of MMPI "cookbooks".

Utility of MMPI "cookbooks".


A comparison of two MMPI actuarial systems used in classifying an alcoholic out-patient population.


The ego strength scale and the Goldberg scale in evaluating clinic outpatients.


Sex and verbal proficiency on the simulation of normalcy procedure.


Brain damage, schizophrenia and five MMPI items.


Overlap as a problem in atlas classification of MMPI profiles.


Prediction of length of hospital stay from MMPI scales.


Influence of omega-amino-acids on blood pressure, catecholamine stores and the pressor response to physostigmine in the rat.


Inhibitory activity of 8-beta-carbobenzyloxyaminomethyl-1,6-dimethyl-10-alpha-ergoline towards stimulant effects by 5-hydroxytryptamine and amphetamine on liver fluke, Fasciola hepatica, in vitro.


The biotransformation of methadone in man: synthesis and identification of a major metabolite.


Distribution of prostaglandins E1,E2, F1-alpha and F2-alpha in some animal tissues.


A note on the effects of 2,4-diamino-5-phenylthiazole and 1, 2, 3, 4-tetrahydro-9-aminoacridine on morphine metabolism.


1-Allyl and 1-(3,3-dimethylallyl) analogues of pethidine and its reversd ester.


The chromatographic analysis of spermaceti.


A note on the solubility of griseofulvin.


The effect of emulsifier concentration on the rheological properties of acacia emulsions.


Similarities in the interatomic distances of some anti-inflammatory agents and inflammagenic amines: a possible insight into their common receptor(s).


Dissociation of analgesic and respiratory depressant properties in N-substituted analogues of etorphine.


Pharmacological activity of cannabis according to the sex of the plant.


The influences of drugs on the uptake of 5-hydroxytryptamine by synaptic vesicles of rabbit brain stem.


The survival of heat resistant spores in aqueous injections after an official sterilization treatment.


Development of antihistamine and anti-allergic activity after prolonged administration of a plant saponin from Clerodendron serratum.


The effect of chlordiazepoxide and fluphenazine on critical flicker frequency.


Development of tolerance to the behavioral depressant effects of alpha-methyltyrosine.


Imipramine affects dopamine uptake by rat brain.


Metabolism of diazepam in isolated perfused liver of rat and mouse.


Microscopical appearance of some oil-in-water emulsions.


Supersensitivity to tyramine not due to monoamine oxidase inhibition.


Surface tension effects of beta-adrenergic blocking drugs.


Hypotensive action of ephedrine in cats.


The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.


Epilepsy.

Epilepsy.


Psychological assessment methods.

Psychological assessment methods.


Normative data on some MMPI scales.

Normative data on some MMPI scales.


Masculinity, femininity, and masculinity-femininity: a phenomenological study of the Mf scale of the MMPI.


Perhaps mode of response does not explain intra-individual variability.


Responses of animals to oxygen at reduced pressure. AMRL-TR-67-78.


Effect of experimental bilateral cryptorchidism on testicular enzymes related to androgen formation.


Effect of hypophyseal growth hormone on the activity of tyrosine transaminase of the isolated perfused rat liver.


Effect of dinitrophenol on thyroid responses to thyrotropin.


Endocrine influences on altered hepatic tyrosine transaminase activity during pneumococcal septicemia in the rat.


Aromatization of delta-7-C19-steroids to delta-7-estrogens by human placenta in vitro.


Effect of trace elements on dental caries.


The storage of transmitters in the central nervous system.


Progesterone biosynthesis in rabbit ovarian interstitial tissue mitochondria.


Metabolic effects of pertussis sensitization in mice and rats.


Influence of brain neurohumors injected into the lateral ventricle of the rat on growth hormone release.


Susceptibility of four types of cutaneous anaphylaxis in the mouse to antihistaminics.


Altered diaphorase activity in optochin-resistant pneumococci. Methylene blue (MB) reductase activities of washed cell suspensions and of cell-free extracts prepared from optochin-resistant mutant pneumococci were two times greater than and four to eight times more resistant to optochin inhibition than those of similar preparations from the optochin-sensitive parent strains. With whole cells, optochin hydrochloride was approximately four times more potent than quinine hydrochloride in inhibiting MB reductase activity. However, with cell-free extracts, both drugs had similar inhibitory activities. Glucose uptake was not affected by optochin hydrochloride, and both optochin-sensitive and optochin-resistant pneumococci had similar glucose uptake patterns. Diaphorase activities of cell-free extracts prepared from optochin-resistant pneumococci were two times greater than and four to eight times more resistant to optochin inhibition than those of cell-free extracts prepared from the optochin-sensitive parent strains. Flavin concentrations of cell-free extracts prepared from optochin-sensitive and optochin-resistant strains were similar.


Purification and properties of mutant and wild-type diaphorases from Diplococcus pneumoniae. Optochin-resistant mutant and wild-type diaphorases were purified approximately 300-fold by a combination of batch adsorption and column chromatography with diethylaminoethyl cellulose, and were characterized with regard to their pH optima, sensitivity to optochin inhibition and heat inactivation, Michaelis constants with flavine mononucleotide (FMN) and reduced nicotinamide adenine dinucleotide (NADH), and inhibition constants with optochin hydrochloride. The pH optima of the purified diaphorases were similar, but the purified diaphorases from the optochin-resistant strains were approximately four to five times more resistant to heat inactivation at 45 C than was the wild-type diaphorase. Purified diaphorase preparations from the optochin-resistant pneumococci had greater activities per milligram of protein and were more resistant to optochin inhibition than the preparation from the optochin-sensitive pneumococcus. Michaelis constants for FMN and NADH were similar; however, the inhibition constants of the optochin-resistant diaphorases were four to eight times greater than that of the optochin-sensitive diaphorase. Optochin hydrochloride produced a noncompetitive type of inhibition with FMN as substrate but a competitive type of inhibition with NADH as substrate. Optochin hydrochloride produced an approximately 10-fold increase in the Michaelis constant for NADH. The concentration of drug required to produce this effect was, however, greater with the mutant diaphorases than with the wild-type diaphorase. Optochin hydrochloride quenched the fluorescence of riboflavine. This phenomenon did not appear to be related to the diaphorase-inhibitory activity of the drug, however, since the pH requirements of the two reactions were different. Quenching of riboflavine fluorescence by optochin hydrochloride increased with a rise in pH, whereas inhibition of diaphorase activity by optochin hydrochloride was greater at pH 6.8 than at pH 7.6.


Mutation in pneumococcus type 3 affecting multiple cistrons concerned with the synthesis of capsular polysaccharide. The genetic behavior in transformation reactions of 20 noncapsulated mutants of pneumococcus type III suggests that each has a single-site mutation in the locus controlling the synthesis of uridine diphosphate glucose (UDPG) dehydrogenase. Each strain is capable of yielding transformants of the binary capsular type SI-III when exposed to deoxyribonucleic acid (DNA) from type I cells. One additional mutant reacted differently and behaved as if it were a multisite mutant with the mutation affecting both the locus for UDPG dehydrogenase and that controlling the synthesis of high molecular weight type III capsular polysaccharide. When exposed to DNA from type I pneumococci, this strain yielded transformants which were genotypically binary but which expressed only the type I capsular phenotype.


A physical and chemical study of sea nettle nematocysts and their toxin.


Prevalence of tori.

Prevalence of tori.


Drugs in management of hyperkinetic and perceptually handicapped children.


Genetic dissection of photosynthesis.

Genetic dissection of photosynthesis.


Detection of complex of D-amino-acid oxidase and D-alanine by rapid scan spectrophotometry.


Isolation and characterization of glutathione reductase from Penicillium chrysogenum.


Short-term group psychotherapy for post-myocardial infarction patients and their wives.


Glutathione reductase-dependent metabolism of cysteine-S-sulfate by Penicillium chrysogenum.


Psycho-social characteristics of check offenders.


Occupational hazards in dentistry.

Occupational hazards in dentistry.


Effect of a school's naturally fluoridated water on the prevalence of carious lesions.


The cariostatic effectiveness of a phosphate-fluoride gel administered annually to school children. I. The results of the first year.


Effect of whole body irradiation with an exposure dose of 1,400 R on pyridine nucleotide values in normal and regenerating rat liver.


Reduced nicotinamide-adenine dinucleotide oxidation by melanin: inhibition by phenothiazines.


Packing your parliamentary suitcase.

Packing your parliamentary suitcase.


Dental services for children in Czechoslovakia.


Reaction between reduced pyridine nucleotides and mercuric ions.


A possible mechanism for the transfer of cytosol-generated NADPH to the mitochondrial mixed-function oxidases in bovine adrenal cortex: a malate shuttle.


Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine.


Pharmacological study of 2-ethyl-4-ethylamino-6-methoxy-s-triazine, a new compound with both central sympathetic and parasympathetic stimulating properties.


Dental Student Conference on Research.

Dental Student Conference on Research.


A review of studies on the self-administration of topical fluorides.


Functional studies on vascular reactivity in different models of experimental hypertension in rats treated with ganglioblocker.


Enhancement effects and the identity of the two photochemical reactions of photosynthesis.


Effects of two antihistamine-containing compounds upon performance at three altitudes.


Three-week exposure of rodents to a neon enriched atmosphere.


Endocrine functions in an oxygen atmosphere at reduced total pressure.


Functional dissociation within hippocampus.


Carbon dioxide retention and metabolic changes during prolonged exposure to high pressure environment.


Oxidative enzyme histochemistry of the chick esophagus and proventriculus.


Factors affecting the growth of bacterial colonies on agar plates.


Mutagenesis in Escherichia coli: evidence for the mechanism of base change mutation by ultraviolet radiation in a strain deficient in excision-repair.


Observations on the electrochemistry of the cochlear endolymph of the rat: a quantitative study of its electrical potential and ionic composition as determined by means of flame spectrophotometry.


Ultrastructural changes of the plasmalemma and the cell wall during the life cycle of Cyanidium caldarium.


Adrenergic mechanism participating in induction of atrial fibrillation by ACh.


Periarteritis nodosa in infancy.

Periarteritis nodosa in infancy.


Primary vaccination with an attenuated strain of vaccinia virus.


Inhibition by antihistamines of the vascular permeability increase induced by bradykinin. 1. Mepyramine and triprolidine hydrochloride have a marked inhibitory effect on the local increase of vascular permeability induced by bradykinin.2. The anti-bradykinin effect of both antihistamines was species dependent, being evident in rabbits, rats and mice but not in guinea-pigs.


Unusual cause of yellow skin.

Unusual cause of yellow skin.


The influence of beta-adrenoceptive receptor blocking agents on urinary function in the rat. 1. Intramuscular or subcutaneous injections of isoprenaline and dichloroisoprenaline and subcutaneous injection of pronethalol reduced the rates of excretion of water, sodium, potassium and chloride in the urine of conscious, hydrated rats. Inulin excretion usually fell at high, but not at low, dose levels. These changes were attributed to direct stimulant actions on beta-adrenoceptors in the kidney.2. A reduction in perfusion pressure to the kidney may also have contributed to these urinary changes, because isoprenaline produced a transient fall in mean arterial blood pressure when given subcutaneously to anaesthetized rats.3. Intramuscular injection of pronethalol and subcutaneous injection of antidiuretic hormone both reduced the rate of urine flow without modifying other parameters of urinary function (excretion of inulin and electrolytes were not diminished).4. This latter action of pronethalol could not be ascribed to an increased secretion of antidiuretic hormone, for it also occurred in hypophysectomized rats.5. Propranolol increased the renal excretion of sodium and chloride. A small rise in urinary potassium levels also occurred but urine volume and inulin excretion were not modified. Some possible modes of action of propranolol are discussed.


Growth and differentiation of Tubularia cells in a chemically defieed physiological medium.


Control of progesterone biosynthesis in the bovine corpus luteum: effects of luteinizing hormone and of reduced nicotinamide-adenine dinucleotide phosphate in vitro.


Potential vectors of dirofilaria immitis in the Brisbane area of Queensland, Australia.


Mosquitoes of the Papuan subregion (Diptera: Culicidae) Toxorhynchites (Toxorhynchites) amboinensis (Doleschall).


Susceptibility of four common Singapore mosquitoes to Dirofilaria immitis Leidy.


Notes on mosquitoes of New Zealand. II. The male terminalia of Culiseta (Climacura) tonnoiri and its ecology (Diptera: Culicidae: culisetini).


The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos.


The reactivity of the pregnant rat myometrium.


Hereditary factors in normal personality traits (as measured by inventories).


Antibodies to pneumococcal polysaccharides: relation between binding and electrophoretic heterogeneity. Antibodies to type III and type VIII pneumococcal polysaccharides were examined with respect to ligand binding and electrophoretic heterogeneity. Both antibodies showed apparent binding homogeneity, although multiple light chain and heavy chain electrophoretic species were demonstrated.


Microsomal N-demethylation, by a cotton leaf oxidase system, of 3-(4'-chloropENYL)-1, 1-dimethylurea (monuron). A cotton leaf microsomal oxidase system that N-demethylates 3-(4'-chlorophenyl)-1,1-dimethylurea (monuron) to 3-(4'-chlorophenyl)-1-methylurea has been partially characterized. The enzyme system is associated with a microsomal fraction separated by differential centrifugation and requires molecular oxygen as well as either the reduced form of nicotinamide adenine dinucleotide phosphate or the reduced form of nicotinamide adenine dinucleotide as cofactors.


D-lactate specific pyridine nucleotide lactate dehydrogenase in animals. A survey of representative invertebrates has revealed the presence of pyridine nucleotide-linked (D)-lactate dehydrogenase in a number of groups. All species studied contained either D(D)-or (L)L-lactate dehydrogenase, but no species contained both enzymes. The (D)-lactate dehydrogenase from Limulus polyphemus has been purified and has a molecular weight of 65,000.


Special modifications of the fluorescent screening method for glucose-6-phosphate dehydrogenase deficiency.


Management of pregnancy complicated by hypertrophic obstructive cardiomyopathy. We report our experiences with nine women suffering from hypertrophic obstructive cardiomyopathy who between them had 13 pregnancies, 10 of which were directly managed by us. Though at first we felt that the theoretical hazards of vaginal delivery indicated elective caesarean section, experience has convinced us that in the absence of an obstetrical contraindication these patients may be delivered vaginally provided a betaadrenergic blocking drug is administered during pregnancy and especially during labour, ergometrine is given at the end of the second stage, adequate supplies of cross-matched blood are available, and prophylaxis against infective endocarditis is administered. We have found no evidence of any adverse effects of either propranolol or pronethalol on the foetus.


Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism.


Factors that influence evaluation conferences in clinical experience.


Clinical observations and actions of nursing students.


A family care study.

A family care study.


Capsulation of pneumococcus with soluble C-like (Cs) polysaccharide. I. Biological and genetic properties of Cs pneumococcal strains. Capsulated mutants of pneumococcus producing a capsule of soluble polysaccharide related immunologically to the C or cell wall polysaccharide of pneumococcus have been isolated from several noncapsulated variants of this organism. The capsular material of these strains reacts with antisera both to homologous strains and to noncapsulated strains of pneumococcus and with human C-reactive protein. C-reactive protein has been shown to give a positive capsular precipitin or Quellung reaction with C(s) pneumococcal variants and to agglutinate them. The genetic locus which determines the production of C(s) polysaccharide is situated in a region of the pneumococcal chromosome distinct from that controlling normal capsular polysaccharide synthesis. Binary and ternary capsulated pneumococci, one of the capsular components of which is C(s) polysaccharide, have been isolated following DNA-mediated transformation.


The psychiatric nursing seminar.

The psychiatric nursing seminar.


What is the student learning in the clinical laboratory?


Evaluation of a new antipsychotic agent. Butaperazine maleate (repoise maleate).


"Dilatin" overdosage.

"Dilatin" overdosage.


The role of hepatic microbody and soluble oxidases in the peroxidation of methanol in the rat and monkey.


"Dilantin" overdosage.

"Dilantin" overdosage.


Patient attitudes and clinical judgment as related to patients' course in hospital.


Studies on reduction of azo-linkages in human placental homogenates.


The effect of some androgenic steroids on anesthesia.


Tahyna virus distribution in viraemic hamster blood.


The Patois group of arboviruses.

The Patois group of arboviruses.


Isolation of Tahyna virus from Aedes mosquitoes in Northern Italy (Gorizia Province).


Quantitative determination of methapyrilene hydrochloride and glyceryl guaiacolate in cough syrups.


Chemistry of the streptovaricins. IV. Structure of varicinal A.


Congenital heart disease in an infant with the Smith-Lemli-Opitz syndrome.


Asymmetric manifestations of an apparently new syndrome: depressed and pitted skin, facial tumors, syndactyly, and other congenital defects.


Adaptation of Bucher's technique to detection of neuro-humors in the hemodialysate. Modification of Bucher's pharmacological method.


Glyceraldehyde-3-phosphate dehydrogenase in photosynthetic tissues: kinetic evidence for competitivity between NADP and NAD.


Complex formation of ferredoxin-NADP reductase with ferredoxin and with NADP.


Enzymatic synthesis of 10-methylene stearic acid and tuberculostearic acid.


A computer simulation of oxidative phosphorylation.


Factors influencing adenosine 3',5'-phosphate accumulation in bovine thyroid slices.


Studies on dihydrofolic reductase. 3. Activation of the chicken liver enzyme by urea and thiourea.


The role of adenosine 3',5'-phosphate in mediating effects of thyroid-stimulating hormone on carbohydrate metabolism of bovine thyroid slices.


Enzyme changes within muscle fibers in genetic and nutritional muscular dystrophy.


Energy sources in hibernator: pyridine nucleotide metabolism.


The isolation and characterization of 3-phosphoglycerate dehydrogenase from peas. 1. 3-Phosphoglycerate dehydrogenase was purified 400-fold from crude extracts of etiolated pea epicotyls. 2. Michaelis constants were determined for all four substrates. 3. Loss of sensitivity to inhibition by l-serine occurs on purification. 4. The purified enzyme is inhibited by thiol-group reagents and, with N-ethyl-maleimide, protection is afforded by 3-phosphoglycerate though not by NAD(+).


The action of paraquat and diquat on the respiration of liver cell fractions. 1. Paraquat and diquat produce only a slight increase in the oxygen uptake of rat liver mitochondria, and it is likely that they do not penetrate the mitochondrial membrane. 2. In mitochondrial fragments inhibited by antimycin A or by Amytal, both substances stimulate oxygen uptake with NADH or beta-hydroxybutyrate as substrate but not with succinate. The NADH dehydrogenase of the respiratory chain appears to be involved, at a site only partially inhibited by Amytal. 3. An NADPH oxidase activity is stimulated in rat liver microsomes by diquat, and to a smaller extent by paraquat; diquat also causes an NADH oxidase activity to develop. The effect is not inhibited by carbon monoxide or p-chloromercuribenzoate, and it is probable that a flavoprotein is involved by a mechanism not requiring thiol groups. 4. One molecule of oxygen can oxidize two molecules of NADPH in the stimulated microsomal system, the hydrogen peroxide produced being broken down by a catalase activity in the microsomes. 5. Diquat can stimulate NADH oxidase and NADPH oxidase activity in the postmicrosomal soluble fraction; the enzyme involved may be DT-diaphorase. 6. The mechanism of these reactions and their significance in relation to the toxicity of the dipyridilium compounds are discussed.


Properties of some reductase enzymes in the nitrifying bacteria and their relationship to the oxidase systems. The reductase enzymes in Nitrosomonas and Nitrobacter were studied under anaerobic conditions when the oxidase enzymes were inactive. The most effective electron-donor systems for nitrate reductase in Nitrobacter were reduced benzyl viologen alone, phenazine methosulphate with either NADH or NADPH, and FMN or FAD with NADH. Nitrite and hydroxylamine reductases were found in both nitrifying bacteria, and optimum activity for each enzyme was obtained with NADH or NADPH with either FMN or FAD. The product of both these enzymes was identified as ammonia. In extracts of Nitrosomonas the ammonia was further utilized by an NADPH-specific glutamate dehydrogenase. (15)N-labelled nitrite, hydroxylamine and ammonia were rapidly incorporated into cell protein by Nitrosomonas, and Nitrobacter in addition incorporated [(15)N]nitrate. Relatively gentle methods of cell disruption were compared with ultrasonic treatment, to enable a more exact study to be undertaken of the intracellular distribution of the oxidase and reductase enzymes. The functional relationship of these opposing enzyme systems in the nitrifying bacteria is considered.


The presence of a substance with hydrogen transporting properties in some samples of methotrexate.


A study of the complement fixing properties of equine antisera.


Beta-adrenergic blocking agents. I. Pronethalol and related N-alkyl and N-aralkyl derivatives of 2-amino-1-(2-naphythyl)ethanol.


Metabolism of brompheniramine.

Metabolism of brompheniramine.


Studies on hydroid differentiation. 3. The replacement of hypostomal gland cells of Podocoryne carnea.


Use of a pancreatin-trypsin solution for the liquefaction of sputa for routine bacteriological examination.


Studies on sea nettle stings.

Studies on sea nettle stings.


Cephaloglycin. Clinical and laboratory experience with an orally administered cephalosporin.


Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clinimycin.


Circadian rhythm of adrenal cortical activity in depression. II. A comparison of types in depression.


Laboratory and clinical evaluation of 7-chloro-7-deoxylincomycin.


The orbit.

The orbit.


The relation between temperature-inducible allosteric effects and the activation energies of amino-acid oxidases.


A field survey of dental caries, periodontal disease and enamel defects in Tristan da Cunha.


Purification and allosteric properties of yeast pyruvate kinase.


Biosynthesis of dihydrosphingosine in vitro.


Forensic odontology.

Forensic odontology.


Mechanism of pulmonary vasoconstrictor effect of thiopental.


Aggression, defense and neurohumors.

Aggression, defense and neurohumors.


The telemetric automated microbial identification system (tamis) and subsystems. Rev 1-68.


Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease.


Ornithine transaminase in the liver of the chick embryo and in the young chick.


Influence of dietary protein on hydrocortisone-mediated adaptive enzymatic changes in rat liver.


A comparative study of the inhibitory action on the oxygen-evolution system of various chemical and physical treatments of Euglena chloroplasts.


Inhibition by aflatonin B-1 of hydrocortisone induction of rat liver tryptophan pyrrolase and tyrosine transaminase.


Inhibition of deoxycytidylic and deoxyguanylic acid kinase activity by adenosine triphosphate and deoxyadenosine triphosphate in pneumococci.


Some pharmacological properties of four stereoisomers of butidrine, a new adrenergic beta-receptor antagonist.


"Superinduction" of tyrosine transaminase in hepatoma cell cultures: differential inhibition of synthesis and turnover by actionomycin D.


Physiological effects of different oxygen flow rates and ambient temperatures on pressure-suited subjects performing work at altitude. NADC-AC-6708.


Influences of cylert upon memory changes with ECT.


Group A Streptococcus resistant to erythromycin and lincomycin.


Preparoxysmal changes of spontaneous and evoked electrical activity of the cat brain after administration of methionine sulphoximine.


Empyema of the thorax in adults: review of 105 cases.


Mediators of increased vascular permeability in turpentine-induced inflammation in the toad (Bufo marinus).


The responses of the spleen to nerve stimulation in relation to the frequency of splenic nerve discharge.


Learning in homosexuality.

Learning in homosexuality.


Tyrosine aminotransferase: enzyme induction independent of adenosine 3', 5'-monophosphate. The importance of adenyl cyclase and adenosine 3',5'-monophosphate in the induction of tyrosine aminotransferase by adrenocorticosteroids has been tested in HTC cells derived from a rat hepatoma and grown in tissue culture. Adrenocorticosteroids cause a 10-to 15-fold increase in the rate of synthesis of tyrosine aminotransferase in these cells. Under various experimental conditions, with or without glucocorticoids, neither adenyl cyclase nor cyclic adenosine mono-phosphate could be detected in HTC cells. In addition, neither the cyclic nucleotide nor N(6), O(2')-dibutyryl cyclic adenosine monophosphate caused increased activity of the transaminase in HTC cells. We conclude that induction of tyrosine aminotransferase by glucocorticoids is not mediated by the adenyl cyclase-cyclic adenosine monophosphate system.


Tyrosine transaminase: development of daily rhythm in liver of neonatal rat. The development of the 24-hour rhythm in tyrosine transaminase activity was studied in the liver of the neonatal rat. A recognizable rhythm appears within 48 hours after birth, but it is opposite in phase to that observed in the adult rat. The reversal of the adult pattern occurs 21 to 23 days after birth and may represent a response to a change both in the eating pattern and in the amount of protein eaten.


Clinical manifestations and treatment of atopy in the dog.


Study of per- and poststimulatory fatigue in pitch perception.


Forme fruste of the Prader-Willi syndrome (HHHO) and balanced D-E translocation.


Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.


Purification and properties of diphosphopyridine nuleotide-linked isocitrate dehydrogenase of mammalian liver.


D-amino acid oxidase. 3. Studies of flavin adenine dinucleotide binding.


Properties of a submicrosomal particle containing P-450 and flavoprotein.


D-glyceraldehyde 3-phosphate dehydrogenases of higher plants. The d-glyceraldehyde 3-P dehydrogenases of spinach leaf, pea seed, and pea shoot were purified. The NADP and NAD-linked enzymes of either spinach leaves and pea shoots could not be separated. Changes in the ratio of NADP- to NAD-linked activity of the spinach leaf and pea shoot enzymes were observed during both purification and storage of crude extracts. The spinach leaf, pea shoot, and pea seed enzymes differ electrophoretically from each other and from the rabbit muscle enzyme. The pea seed and shoot enzymes contain bound nucleotide cofactor, resist proteolytic attack, have similar Michaelis-Menton kinetic constants and are competitively inhibited by d-sedoheptulose-7-phosphate and d-sedoheptulose 1,7-diphosphate. Charcoal removes the bound nucleotide from the pea seed enzyme but not from the pea shoot enzymes. NADP and NADPH were found to inhibit the reductive but not oxidative reaction catalyzed by the charcoal treated seed enzyme. The function of the pea shoot NADP and NAD-linked enzymes in chloroplast metabolism is discussed in regard to their location and catalytic properties. Although the NADP-linked activity can be assigned a primary, if not exclusive function in photosynthesis, the assignment of a distinct metabolic function to the NAD-linked activity cannot be made at present.


Deficiency of reduced nicotinamide-adenine dinucleotide oxidase in chronic granulomatous disease. Reduced nicotinamide-adenine dinucleotide oxidase of normal human polymorphonuclear leukocytes has properties that would qualify it as the enzyme responsible for the respiratory burst during phagocytosis. The enzyme was deficient in leukocytes of five patients with chronic granulomatous disease. This lack of adequate reduced nicotinamide-adenine dinucleotide oxidase could be the basis for the metabolic abnormalities characteristic of these leukocytes and for their diminished bactericidal activity.


Antihistaminic activity of adrenergic beta-receptors blocking drugs.


The biochemists' green mansions: the photosynthetic electron-transport chain in plants.


Rabbit erythrocyte pyridinnucleotides and nucleosidase activity after x-ray irradiation.


Pyridine nucleotide content in rat liver mitochondria after whole-body x-irradiation with 1400 R.


Cholinergic brain mechanisms and behaviour.


Pattern of nicotinamide nucleotides in the erythrocytes of pellagrins.


Comparison of the antibacterial activity of rifampicin and other antibiotics.


MMPI performances in major motor, psychomotor and mixed seizure classifications of known and unknown etiology.


Laboratory and clinical evaluation of rifampicin.


Psychochemical research studies in man.

Psychochemical research studies in man.


Hormonal effects on enzyme activities in tissue culture and in whole animals.


Cellular factors in genetic transformation.


Successful treatment of a fulminant hypertensive crisis after bilateral carotid sinus denervation.


DPN- and TPN-17beta-hydroxy-C19-steroid dehydrogenases; intracellular localization in dog prostate.


Acute enzyme histochemical changes in the zona glomerulosa of the rat adrenal cortex. I. The effect of peritoneal dialysis with a glucose 5 percent solution.


Emotionality, extraversion and aggression in paranoid and nonparanoid schizophrenic offenders.


Studies with new drugs in the treatment of convulsive disorders.


A study of properties of renal microbodies of the rat.


Metabolism of norepinephrine, serotonin and dopamine in rat brain with stress.


The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.


Direct relaxant actions of procaine and tetrodotoxin on vascular smooth muscle.


Influence of vasculat upon the intraocular pressure and on formation of aqueous humour in experiments on animals.


Evaluation of butaperazine in chronic schizophrenia.


Glucose dehydrogenase activity of yeast glucose 6-phosphate dehydrogenase. II. Kinetic studies of the mode of activation by bicarbonate, phosphate, and sulfate.


Rat-liver thiol: protein-disulphide oxidoreductase.


Intrasubject variability in amplitude of Bekesy tracings and its relation to measures of personality.


Adolescent voice quality aberrations: personality and social status.


Parental schemata in emotionally disturbed women.


Human adjustment to an exotic environment: the nuclear submarine.


Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement.


Distribution of glutamic acid, aspartic acid, gamma-aminobutyric acid and glycine in six areas of cat spinal cord before and after transection.


Urticaria.

Urticaria.


Effect of chronic cardiac sympathectomy on the therapeutic and toxic actions of digitalis in the dog heart-lung preparation.


Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.


Histochemical study on the adrenal cortices of human newborns and infants.


Multiple endocrine adenomatosis.

Multiple endocrine adenomatosis.


Effects of intraventricularly administered adrenaline on rabbit's EEG and their modifications by adrenergic blocking agents.


Drug metabolism in tumor-bearing rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of tumor-bearing rats.


A numerical taxonomic study of human oral streptococci.


Use of 2-3H-D, L-tyrosine in a rapid and sensitive isotopic assay for tyrosine aminotransferase.


Circadian rhythm of adrenal cortical activity in depression. I. A comparison of depressed patients with normal subjects.


Limitations of simplified indices in prevalence studies of periodontal diseases. A survey of the school population of French Polynesia.


Factors in the host-virus relationship which may affect the course of an infection.


Hypertension and neuro-humoral substances.


Metabolism of androst-4-ene-3,17-dione-4-14C by rabbit skeletal muscle in vitro. The presence of a 5-alpha steroid reductase in the particulate fraction.


Declaration of sydney--a statement on death.


Quantitative studies of the specificity of anti-pneumococcal polysaccharide antibodies, types 3 and 8. 3. Binding of a labeled oligosaccharide derived from S8 by anti-S8 antibodies.


Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.


The diagnostic utility of Welsh's A-R categories.


Comparative findings in school systems with differing approaches to dental health education.


The spectrum of hepatotoxicity.

The spectrum of hepatotoxicity.


17-beta-hydroxy-C19-steroid dehydrogenase activity of dog prostate, solubilization and partial purification and characterization.


Particles resembling microbodies in normal and neoplastic perianal glands of dogs.


ave you ever taken part in a careers convention?


Longer space voyages.

Longer space voyages.


History of the New Jersey State Dental Society. II. The 6th Annual Convention, 1876.


Schizodontia.

Schizodontia.


International patterns of oral health care--the example of New Zealand.


Bionomics of Psorophora varipes, a model laboratory mosquito.


Aerobic metabolism of uniformly labelled [14C]glucose in tissue slices of rat testis.


Hypoing your annuaal session.

Hypoing your annuaal session.


I. Analgesic and dependence-producing properties of drugs.


Replantation of teeth after trauma.

Replantation of teeth after trauma.


In vivo assessment of the solubility of tooth enamel during an FBM patrol. Rep. No. 537.


Personal habits and diet in relation to periodontal health and oral hygiene status in submariners. Rep. No. 528.


Taste thresholds to bitter compounds during a submarine patrol. Rep. No. 538.


Oral health of the Nasioi of Bougainville.


Epidemiology in Papua-New Guinea. II. Dental caries.


Summary of 32nd Annual Meeting Pacific Coast Society of Orthodontists, Honolulu, Hawaii, September 14 through 20.


Dental health status of the New Zealand population in late adolescence and young adulthood.


Systematic application of gas chromatography to the analysis of pharmaceutical preparations.


Functional disorders of the brain induced by synthesis of nucleotides containing 3-acetylpyridine.


Medical management of ulcerative colitis.


Influences of different stimulus intensities on the human somatosensory evoked response (a proposal for the data processing).


Treatment of ulcerative colitis with salazopyrin.


Thermodynamic evaluation of the formation of complexes of D-amino-acid oxidase with saturated straight-chain fatty acids.


Personal constructs and personal characteristics.


Susceptibility of Mansonia mosquitoes to certain insecticides in Thailand.


The susceptibility of various species of mosquitoes to DDT and dieldrin in Thailand.


The Forssman antigen of pneumococcus.

The Forssman antigen of pneumococcus.


Studies on karyotypes of some Japanese mosquitoes.


Immunological properties of anti-pneumococcus rabbit serum as heterophile antibodies.


On the lipids of Diplococcus pneumoniae type I-R-44. Separation of glycolipids from phospholipids by silicic acid column chromatography.


Cytokinesis: filaments in the cleavage furrow.


Pre-admission testing--a Blue Cross proposal.


Effects of whole-body x-irradiation on nuclear RNA polymerase activities in rat tissues.


Fractionated strands of bacterial deoxyribonucleic acid. 3. Transformation efficiencies and rates of phenotypic expression. Preferential binding of guanine-rich ribopolymers to one of the complementary strands of denatured deoxyribonucleic acid (DNA) of Diplococcus pneumoniae permitted the fractionation of the complements in CsCl density gradients. Phenotypic expression of the newly acquired genes for four drug resistances was more rapid in cells transformed by the heavy fractions than in those transformed either by light fractions or by unfractionated DNA. The efficiencies of transformation with the two complements were nearly equal for the four markers tested. Both efficiency and expression results were the same whether we assayed the residual activity or the activity obtained by annealing the fractions with excess recipient DNA.


Preparation of testis non-heme iron protein and substitution for adrenodoxin by various non-heme iron proteins in steroid 11-beta-hydroxylation.


Physiological role of malic enzymes in the liver.


Formation of pipecolic acid from D-lysine through the anaerobic reaction catalyzed by D-amino acid oxidase.


Microsporidia parasitizing mosquitoes collected in Connecticut.


Coming to Conference?

Coming to Conference?


Entomophthora coronata as a pathogen of mosquitoes.


Enzymatic determination of small quantities of hydrogen peroxide.


Invasion of privacy and judged benefit of personality-test inquiry.


Advances in the treatment of diseases of the ear, nose and throat.


Inhibition of hepatic enzyme induction as a sensitive assay for endotoxin. Bacterial endotoxins in mice reduced the induction by cortisone of two hepatic enzymes, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase, they prevented the glyconeogenesis in liver induced by the same hormone, and they induced in intact animals the liver enzyme tyrosine-alpha-ketoglutarate transaminase, all in proportion to their ld(50). When cortisone was given in the least amount (100 mug), it resulted in near maximal induction of tryptophan oxygenase; a smaller amount of endotoxin reduced significantly the level of enzyme than that required when 5 mg of hormone was injected. The smallest amount of endotoxin that prevented tryptophan oxygenase induction was given intravenously to adrenalectomized mice in which 25 mug of cortisone was administered. The amount (0.01 mug) is 1/40,000th of the ld(50). The other metabolic processes subject to alteration by endotoxin required at least 100 to 400 times as much. This property of endotoxin can serve as a sensitive bioassay, although the dose-response curve is steep.


Uridine diphosphate D-glucose dehydrogenase of Aerobacter aerogenes. Uridine diphosphate d-glucose dehydrogenase (EC 1.1.1.22) from Aerobacter aerogenes has been partially purified and its properties have been investigated. The molecular weight of the enzyme is between 70,000 and 100,000. Uridine diphosphate d-glucose is a substrate; the diphosphoglucose derivatives of adenosine, cytidine, guanosine, and thymidine are not substrates. Nicotinamide adenine dinucleotide (NAD), but not nicotinamide adenine dinucleotide phosphate, is active as hydrogen acceptor. The pH optimum is between 9.4 and 9.7; the K(m) is 0.6 mm for uridine diphosphate d-glucose and 0.06 mm for NAD. Inhibition of the enzyme by uridine diphosphate d-xylose is noncooperative and of mixed type; the K(i) is 0.08 mm. Thus, uridine diphosphate d-glucose dehydrogenase from A. aerogenes differs from the enzyme from mammalian liver, higher plants, and Cryptococcus laurentii, in which uridine diphosphate d-xylose functions as a cooperative, allosteric feedback inhibitor.


Evaluation of possible adrenergic and cholinergic mechanisms in sympathetic vasodilation.


Formation and metabolism of cholest-5-ene-3beta,12alpha-diol. Bile acids and steroids 205.


Dental injuries of school-children.

Dental injuries of school-children.


From land to space in a generation: an evolutionary challenge.


Progress in tumor enzymology.

Progress in tumor enzymology.


Adaptation of dogs to 60 and 90 mm. Hg CO2 at a total pressure of 260 mm. Hg.


Public health aspects of galactic radiation exposure at supersonic transport altitudes.


Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation.


Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney. Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe(2+), and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient iron as an impurity to provide strong enhancement of the reaction in the absence of added iron. The decarboxylation could also be shown to occur nonenzymatically in the presence of ascorbate, Fe(2+), and boiled microsomes, but there was little autoxidation resulting in decarboxylation. The reaction was strongly inhibited by chelating agents, N,N'-diphenyl-p-phenylene diamine, phenazine methosulfate, and ferricyanide, and resembled lipid peroxidation in both its cofactor requirements and response to inhibitors. The product of the reaction appeared to lack only the C-15 of the original retinoic acid molecule. It was not retained by diethylaminoethyl cellulose, was more polar than retinoic acid upon silicic acid chromatography, had a lower UV absorption maximum (295 m micro ) than the starting product, and seemed to have an aldehyde group at C-14. The physiological significance of the decarboxylation remains to be assessed, but its rapidity makes it important to in vitro work on retinoic acid.


Research on the effects of alteration of the indigenous microflora of the monkey. AMRL-TR-67-177.


Carbon dioxide reduction and water electrolysis system. AMRL-TR-67-227.


Dietary effects on rat liver enzymes in meal-fed rats.


Compendium of human responses to the aerospace environment. 6. Thermal environment. NASA CR-1205(1).


Exploring the brain with drugs.

Exploring the brain with drugs.


Effect of RNA on storage denaturation of DNA.


Effect of x-radiation on the ribosomes of yeast cells.


Phospholipids (PL) retard and cholesterol (chol) promotes the formation of tumours induced by carcinogenic hydrocarbons.


Stimulation of glycollate excretion of algae by disalicylidenepropanediamine and hydroxypyridinemethanesulfonate.


Investigations of an outbreak of Venezuelan equine encephalitis in towns of eastern Venezuela.


Wyeomyla-virus isolations in Trinidad, West Indies.


Contact-spread of Venezuelan equine encephalomyelitis virus among cotton rats via urine or feces and the naso- or oropharynx. A possible transmission cycle in nature.


Effect of inoculum size on in vitro susceptibility testing with lincomycin. There is disagreement in the literature as to whether lincomycin is primarily a bacteriostatic or a bactericidal agent against gram-positive cocci and also regarding the levels of activity of this agent against susceptible microorganisms. These questions were examined in a study of the effect of inoculum size on the results of tube dilution susceptibility determinations with lincomycin against 49 clinical isolates of Staphylococcus aureus and 25 strains of streptococci and pneumococci. Lincomycin was both highly active and bactericidal when tested against 40 strains of S. aureus with inocula containing a maximum of 10(4) cells per ml [median minimal inhibitory concentration (MIC), 0.78 mug/ml; median minimal bactericidal concentration (MBC), 1.56 mug/ml]. With inocula of 10(5) cells per ml, lincomycin was primarily bacteriostatic (median MIC, 1.56 mug/ml; median MBC, 12.5 mug/ml). There were further decreases in inhibitory levels and significant losses of bactericidal activity when inocula containing more than 10(7) cells were tested (median MIC, 3.13 mug/ml; median MBC > 100 mug/ml). Similar measurements with streptococci and pneumococci revealed a lesser effect of inoculum size. The mean MBC value for alpha-hemolytic streptococci increased from 0.40 to 1.05 mug/ml with an increase in inocula from 10(4) to 10(6) cells per ml, but without a marked increase in MIC values. Similar results were obtained for beta-hemolytic streptococci and pneumococci.


Cephalexin and cephaloglycin activity in vitro and absorption and urinary excretion of single oral doses in normal young adults. A large number of recently isolated bacterial pathogens were tested for susceptibility to cephalexin and cephaloglycin by the replica inoculating method. Strains of group A hemolytic streptococci, viridans (alpha and gamma) streptococci, pneumococci, gonococci, meningococci, and penicillin G-sensitive Staphylococcus aureus were all moderately to highly susceptible to both of these cephalosporin analogues, nearly all of the strains being two to eight (median four) times more susceptible to cephaloglycin than to cephalexin. The penicillin G-resistant, penicillinase-producing strains of S. aureus varied in their susceptibility; many were moderately resistant to both analogues, particularly to cephalexin. Strains of enterococci, Haemophilus influenzae, and most of the common gram-negative bacilli were moderately to highly resistant. Reducing the size of the inoculum had variable effects on inhibition by these drugs, depending on the species or strain. The activity of cephalexin was very little affected by pH of the medium within the clinical range or by incubation at 37 C in broth for up to 24 hr. In contrast, cephaloglycin in broth deteriorated rapidly at 37 C, and its activity was markedly reduced in alkaline medium. Both cephalexin and cephaloglycin were rapidly absorbed and excreted into the urine after single oral doses of 500 mg. Much higher levels were achieved and sustained with the former. Absorption of both analogues was delayed when taken with food, and the levels in the serum were significantly higher and better sustained when probenecid was also given. Very high concentrations of cephalexin were excreted into the urine during the first 4 hr, and the levels were still high in the 4- to 8-hr collection. The concentrations of cephaloglycin in the urine at these times were much lower. An average of 80 to 93% of the dose of cephalexin and 25 to 30% of the cephaloglycin were accounted for as active drug in the urine collected in 8 hr. Both analogues were well tolerated.


The mechanisms of reductive carboxylation reactions. Carbon dioxide or bicarbonate as substrate of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase and malic enzyme. 1. A simple kinetic method was devised to show whether dissolved CO(2) or HCO(3)- ion is the substrate in enzyme-catalysed carboxylation reactions. 2. The time-course of the reductive carboxylation of 2-oxoglutarate by NADPH, catalysed by isocitrate dehydrogenase, was studied by a sensitive fluorimetric method at pH7.3 and pH6.4, with large concentrations of substrate and coenzyme and small carbon dioxide concentrations. 3. Reaction was initiated by the addition of carbon dioxide in one of three forms: (i) as the dissolved gas in equilibrium with bicarbonate; (ii) as unbuffered bicarbonate solution; (iii) as the gas or as an unbuffered solution of the gas in water. Different progress curves were obtained in the three cases. 4. The results show that dissolved CO(2) is the primary substrate of the enzyme, and that HCO(3)- ion is at best a very poor substrate. The progress curves are in quantitative agreement with this conclusion and with the known rates of the reversible hydration of CO(2) under the conditions of the experiments. The effects of carbonic anhydrase confirm the conclusions. 5. Similar experiments on the reductive carboxylation of pyruvate catalysed by the ;malic' enzyme show that dissolved CO(2) is the primary substrate of this enzyme also. 6. The results are discussed in relation to the mechanisms of these enzymes, and the effects of pH on the reactions. 7. The advantages of the method and its possible applications to other enzymes involved in carbon dioxide metabolism are discussed.


Carbenicillin: activity in vitro and absorption and excretion in normal young men. Carbenicillin is a new semisynthetic penicillin which differs from other penicillins in showing moderate antibacterial activity against Pseudomonas. Its activity in vitro is enhanced at low pH. Serum binding is of low order and does not appreciably alter activity. Strains of Pseudomonas exposed to subinhibitory concentrations of carbenicillin rapidly develop resistance by a mechanism that does not depend upon destruction of the drug. In normal subjects, high levels of anti-Pseudomonas activity are readily obtained in the urine after intramuscular injection. Levels of carbenicillin adequate to inhibit many strains of Pseudomonas can be achieved in serum only with an intravenous administration of a large dose. Carbenicillin appears to exhibit the same low degree of toxicity as do other penicillins.


The equilibrium constant of the isocitrate dehydrogenase reaction. 1. The equilibrium constant for oxidative decarboxylation of isocitrate by NADP(+), catalysed by isocitrate dehydrogenase, was measured in solutions of various ionic strengths and at several temperatures. 2. Thermodynamic values for the reaction were obtained by extrapolation to zero ionic strength, and the heat of reaction was estimated. 3. The effect of Mg(2+) ion concentration on the equilibrium was studied.


Development of the 21-hydroxysteroid dehydrogenases of rat and bovine liver.


Difference in effects of thyroidectomy and thyroxine supplement on hepatic and anterior pituitary enzymes in the rat.


Daily rhythms in the hydroxylation of 3-beta-hydroxyandrost-5-en-17-one by rat liver microsomes.


Presence and mobilization of glycogen in mammalian pancreatic beta cells.


Oxygen uptake and 14CO2 production from citrate and isocitrate by control and parathyroid hormone-treated bone maintained in tissue culture.


Polyarteritis nodosa presenting as an acute abdomen.


A pyridine nucleotide requirement for the enzymatic conversion of delta-7-cholesten-3-beta-ol to 7-dehydrocholesterol.


The use of personality and attitude tests in predicting the academic success of medical and law students.


Influence of gas environment on catabolic activities and on reoxidation of reduced nicotinamide adenine dinucleotide phosphate in Chlamydia. We investigated the effect of the gas environment on the enzymatic reactions of intact isolated cells of the agents of trachoma and of meningopneumonitis of the host-dependent genus Chlamydia. In comparison with the reactions taking place in a gas phase of air, O(2) depressed CO(2) production from pyruvate and glutamate by trachoma and from glutamate by meningopneumonitis. O(2) enhanced the degradation of pyruvate by meningopneumonitis, but this effect was due to increased H(2)O(2), and was reversed by added catalase. Both dehydrogenation of alpha-ketoglutarate and was reversed by added catalase. Dehydrogenation of alpha-ketoglutarate by both agents and production of CO(2) from C(1) of glucose-6-phosphate were stimulated by O(2) and depressed in N(2). The latter activity was stimulated in air, O(2), and N(2) by nicotinamide adenine dinucleotide phosphate (NADP) in relation to the amount added, and also in air or O(2), but not in N(2), by moderate amounts of NADP and an excess of oxidized glutathione with concomitant formation of H(2)O(2). A small but significant amount of O(2) was consumed during the course of these reactions. It is suggested that glutathione reductase activity can occur only when accompanied by an oxidative reaction, and that this close link between the two reactions represents a mechanism of electron transport which transfers hydrogen to molecular O(2).


Effect of beta adrenergic blocking agents on stress induced changes in acetylcholine content of rat's myocardium.


A comparison of the effects of tetraethylammonium, triethylcholine and hemicholinium on choline uptake by the isolated perfused rabbit heart.


Effect of beta adrenergic receptor blockade on skeletal muscle vasodilatation produced by isoxsuprine and nylidrin.


Anesthesia and descending influences on the brain stem reticular formation.


Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3.


Teratology and reproduction studies with an antinauseant.


Liquid crystals.

Liquid crystals.


Issues before the house.

Issues before the house.


Effect of prolonged administration of an anticholinergic drug, propantheline bromide, on gastric histology and acid secretion.


Evidence for the humoral control of the hypothalamic-pituitary-adrenal axis.


Role of the chemoreceptor trigger zone in histamine-induced emesis. 1. In unanaesthetized dogs, the emetic action of histamine was studied after its injection into the cerebral venricles through chronically implanted cannulae in order to elucidate the role of the chemoreceptor trigger zone (CT-zone), situated in the area postrema, for this emesis.2. On injection into the lateral cerebral ventricle, about 10 times larger doses of histamine (3 mg) were required regularly to produce emesis, and it occurred after a longer latency than on injection into the fourth ventricle. This is in accord with an action of histamine on the CT-zone.3. After bilateral ablation of the CT-zone, intraventricular injections of histamine no longer produced emesis even when injected in doses which were three to four times greater than those which regularly elicited vomiting in dogs with intact CT-zone. The emesis produced in dogs by intraventricular injections of histamine is thus fully accounted for by an action on the CT-zone.4. Injections of chlorpromazine intramuscularly or of the two antihistamines cyclizine and mepyramine, either intramuscularly or into the lateral ventricle, prevented the emesis caused by histamine injected into the lateral ventricle. This protective action of the antihistamines-which did not extend to the emesis produced by oral copper sulphate-suggests the presence of histaminergic receptors in the CT-zone.


Sensitivity to a phenothiazine (butaperazine).


An unusual neurological side effect of psychotropic drug treatment.


Lunar gravity simulation and its effect on human performance.


Isolation and characterization of human liver aldehyde dehydrogenase.


Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.


Rubber-gas partition coefficients.

Rubber-gas partition coefficients.


School fluoridation studies in Elk Lake, Pennsylvania, and Pike County, Kentucky--results after eight years.


Anesthetic potency determined by depression of synaptic transmission.


The formation of 5-formyluracil by cell-free preparations from Neurospora crassa.


The chemical contral of feeding behavior in Cyphastrea ocellina and in some other Hawaiian corals.


Ferredoxin-dependent reduction of nicotinamide-adenine dinucleotides with hydrogen gas by subcellular preparations from the photosynthetic bacterium, Chromatium.


Participation of the microsomal electron transport system involving cytochrome P-450 in omega-oxidation of fatty acids.


Transformation and restoration of biconcave shape of human erythrocytes induced by amphiphilic agents and changes of ionic environment.


Nonspecific esterases in moquitos.

Nonspecific esterases in moquitos.


Influences of quinidine and mepyramine on adrenaline-induced lipolysis.


Action of insulin and triiodothyronine on energy-controlled pathways of hydrogen.


Modification by antihistaminic drugs of the morphine analgesia in rabbits.


Fluoride and caries: observations on the effects of prenatal and postnatal fluoride on some Perth pre-school children.


The biochemical identification of blood and bone marrow cells of patients with acute leukemia.


The pattern of demineralization of the enamel by dental caries.


Dental health in some Penang schools.

Dental health in some Penang schools.


Dental health survey of primary school children in a rural area of Lucknow.


Methylene blue uptake and the reversal of chemically induced methemoglobinemias in human erythrocytes.


Studies on the reduction of aromatic nitro groups in human and rodent placental homogenates.


Dental health problems in Malaysia, Singapore and Nigeria.


Histamine and some antihistamines: their actions on cerebral cortical neurones.


Sulfenyl halides as modifying reagents for polypeptides and proteins. IV. On the conversion of 2-thio-aryl-tryptophan to 2-hydroxy-tryptophan.


On the metabolism of carotenoids in the crustacean Artemia salina.


The effect of purine and pyrimidine compounds on the virus-host cell interation. I. The effect on interferon production and virus multiplication.


The effect of purine and pyrimidine compounds on the virus-host cell interaction. II. The effect on interferon action.


Production of mature virus particles by Escherichia coli spheroplasts infected with lipid-treated RNA of Ranikhet disease virus and with vaccinia and Ranikhet disease viruses.


Host-cell repair of ultraviolet-irradiated pseudorabies virus in chick embryo cells.


Inactivation of single- and double-stranded ribonucleic acid of encephalomyocarditis virus by ultraviolet light.


Virus multiplication and carbohydrate--oxidative metabolism. 3. Study on lactate dehydrogenase in the multiplication of influenza and poxviruses.


Comparative study of Langat and tick-borne encephalitis viruses in cultured cells.


Studies on tick-borne encephalitis virus. I. Partial purification of virus from rat brain suspensions.


Distribution of clover phyllody virus in the leafhopper Macrosteles fascifrons (Stal).


Enhancing effect of anti-endotoxic serum on interferon induction in mouse peritoneal cells by endotoxin.


Multiplication of pseudorabies virus in the inguinal lymph nodes of pigs.


Neutralizing antibodies of low molecular weight in sera from tick-borne encephalitis patients.


Mechanism of the deoxyribonucleic acid helping effect during transformation.


Vasculitis of the breasts.

Vasculitis of the breasts.


Formation of yeast mitochondria. II. Effects of antibiotics on enzyme activity during derepression.


The retinopathy in polyarteritis nodosa.