Effects of a convulsant barbiturate on the spinal monosynaptic pathway.


Personality correlates of self-disclosure.


As others see us? The medieval multi-purpose inquiry.


Daily rhythm of liver tyrosine transaminase and of plasma tyrosine and glucose after removal of the pancreas of rats.


Life history and personality correlates of dominant-submissive behavior.


Tetrazolium salts: antagonism of acetylcholine and histamine response on isolated guinea pig ileum by 2:3:5:triphenyl-tetrazolium chloride.


Metabolism of fungicides and related compounds.


Aggressiveness and psychophysiological responsivity in groups of repressors and sensitizers.


Some relationships between effects of insecticides and other stress conditions.


Influence of chlorinated hydrocarbons and organophosphate insecticides on metabolism of steroids.


Metabolism of insecticides in plants and animals.


The effects of oestrogens on bluing lesions by bradykinin and histamine.


On the pharmacology of guanoxan.

On the pharmacology of guanoxan.


1-piperidino-3-(4'-octylphenyl)-propane-3-one-hydrochloride, a new peripheral and coronary vasodilator.


Vitamin B1 is not a systemic mosquito repellent in man.


Histochemistry of Purkinje cells in experimental homogenisation necrosis.


Enzymic hydroxylation.

Enzymic hydroxylation.


The laboratory diagnosis of enzyme defects in the red cell.


The beta adrenergic receptor and cyclic 3',5'-adenosine monophosphate: possible roles in the regulation of melanophore responses of the spadefoot toad, Scaphiopus couchi.


Effects of dilantin and phenobarbitone on histamine and antihistamine activity in various dog tissues.


An investigation into the bradycardic effects of ST 155 [2-(2,6-dichlorophenylamino)-2-imidazoline HCl] in the anesthetized dog.


Narcotic-antagonist analgesics: interactions with cholinergic systems.


The effect of simulated altitude exposure on the lethality of sympathomimetic amines.


Modification of parathion toxicity to wax moth larvae by chlorcyclizine, aminopyrine or phenobarbital.


The hemolytic properties of extracts of tentacles from the cnidarian Chironex fleckeri.


Some epidemiological observations on the etiology of regional enteritis.


An immunochemical study of D-amino-acid oxidase.


Spectrophotometric identification of the purple complex as an intermediate of the reaction of D-amino-acid oxidase using stopped-flow technique.


The nutritional relationship of Anemonia sulcata (Pennant) and its dinoflagellate symbiont.


The developmental genetics of polymorphism in the rotifer Asplanchna. II. A method for quantitative analysis of changes in morphogenesis induced by vitamin E, and the short-term inheritance of the effects of vitamin E.


The developmental genetics of polymorphism in the rotifer Asplanchna. 3. Quantitative modification of developmental responses to vitamin E, by the genome, physiological state, and population density of responding females.


Changes in epididymal spermatozoa and in the testes of rabbits after experimental cryptorchidism.


Some autonomic effects of Physalia toxin.


Reexamination of enzyme activities thought to show evidence of a coenzyme role for vitamin A.


Inhibition of anesthetics and sedative actions by spironolactone.


Studies on the mechanism of induction of tyrosine aminotransferase in neonatal rat liver.


A thermodynamic approach to problems of drug antagonism I. The "Charnière theory".


A double-blind comparison of trifluperidol and trifluoperazine in acute schizophrenic patients.


Nicotinamide adenine dinucleotide phosphate-linked xylitol dehydrogenase in guinea pig liver cytosol.


Induction of hepatic enzymes by adenosine 3',5'-monophosphate in organ culture.


Hepatic tyrosine transaminase rhythm: interaction of environmental lighting, food consumption and dietary protein content.


Homotransplantation of both kidneys from an anencephalic monster to a 17 pound boy with Eagle-Barret syndrome.


Behavior in ex-addict female prisoners participating in a research study.


Perceptual, concept shift, and personality test performance of matched psychiatric outpatient groups.


The therapeutic implications of the hypothesis of allergic hypersensitivity as dysfunction of the intracellular immune mechanism.


Bacteriology of corneal ulcer with special reference to hypopyon corneal ulcer.


Evaluation of topical applications of stannous fluoride to teeth of children born and reared in a fluoridated community: final report.


Feasibility of the use of stannous fluoride mouthwash in a school system.


Synapsis of the human supraoptic nucleus.


Influence of some drugs on chlorpromazine-induced adrenaline release.


The hydroxylation of p-coumaric acid by an enzyme from leaves of spinach beet (Beta vulgaris L.). 1. An enzyme from the leaves of spinach beet (Beta vulgaris L.) that catalyses the hydroxylation of p-coumaric acid to caffeic acid in the presence of ascorbate has been purified about 1000-fold on a protein basis. 2. It is activated by high concentrations of ammonium sulphate and sodium chloride. 3. The preparation shows both hydroxylase and catechol oxidase activities, in a constant ratio throughout the purification procedure; they are similarly activated by salts. 4. Ascorbate acts as a reductant in quantities equivalent to the caffeic acid produced by hydroxylation. 5. Ascorbate can be replaced by tetrahydrofolic acid, NADH, NADPH or 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine, but not by caffeic acid. Among these, the pteridine is the most effective, but the reaction is not inhibited by aminopterin. In experiments with saturating concentrations of NADH and the pteridine, these reductants compete in the reaction and are equivalent on a molar basis. 6. No cofactor has been separated from the enzyme by prolonged dialysis. 7. The relation of the enzyme to other hydroxylases and phenolases is discussed.


Fate of vasopressin and oxytocin in the pulmonary circulation.


Dihydropteridine reductase. A method for the measurement of activity, and investigations of the specificity for NADH and NADPH.


Effects of phosphate and other ionic compounds on the activity of crystalline beef liver glutamate dehydrogenase.


Human placental 17 beta-estradiol dehydrogenase. IV. Differentiation of 17 beta-estradiol-activated transhydrogenase from the transhydrogenase function of 17 beta-estradiol dehydrogenase.


Augmentation of spontaneous hypertension by chronic stress in rats.


Traumatised permanent teeth in children--a follow-up. I. Pulpal complications and root resorption.


Comparative morphology of small vessel lesions in rheumatoid arthritis and periarteritis nodosa.


Traumatised permanent teeth in children--a follow-up. II. The crown fractures.


An evaluation of the French, Spanish, and German translations of the MMPI.


Pharmacotherapy and community psychiatric practice.


Emotional and cognitive changes in pregnancy and early puerperium.


Biochemistry and pharmacology of autonomic neurons.


Faecal flora of patients with ulcerative colitis during treatment with salicylazosulphapyridine.


The action spectrum of xanthotoxin and bergapten for the photoreaction with native DNA.


Fluorescent and non fluorescent C4-cycloadducts in the photoreaction at 365 nm between psoralen-3H and DNA.


Oxygen activation by the iron(II)-2-mercaptobenzoic acid complex. A model for microsomal mixed function oxygenases.


Photoactivation of aerobically and anaerobically grown diploid yeast cells under aerobe and hypoxic conditions.


Lipids of Protosiphon (Chlorophyta). I. Carotenoids and carotenoid esters of five strains of Protosiphon botryoides (Kütz.) Klebs.


Spleen gangliosides: "the structure of ganglioside GLNnT1(NGNA)".


Quantitation of microorganisms in sputum. A method of quantitating microbial cultures of homogenized sputum has been devised. Possible application of this method to the problem of determining the etiologic agent of lower-respiratory-tract infections has been studied to determine its usefulness as a guide in the management of these infections. Specimens were liquefied by using an equal volume of 2% N-acetyl-L-cysteine. The liquefied sputum suspension was serially diluted to 10(-1), 10(-3), 10(-5), and 10(-7). These dilutions were plated on appropriate media by using an 0.01-ml calibrated loop; they were incubated and examined by standard diagnostic methods. Quantitation of fresh sputum from patients with pneumonia prior to antimicrobial therapy revealed that probable pathogens were present in populations of 10(7) organisms/ml or greater. Normal oropharyngeal flora did not occur in these numbers before therapy. Comparison of microbial counts on fresh and aged sputum showed that it is necessary to use only fresh specimens, since multiplication or death alters both quantitative and qualitative findings. Proper collection and quantitative culturing of homogenized sputum provided information more directly applicable to patient management than did qualitative routine methods. Not only was the recognition of the probable pathogenic organism in pneumonia patients improved, but serial quantitative cultures were particularly useful in recognizing the emergence of superinfections and in evaluating the efficacy of antimicrobial therapy.


On the pharmacologic properties of substituted derivatives of bis-(aminopropyl)-benzene.


Ganglionic blocking properties of the diuretic agent amiloride hydrochloride.


Analysis of pressor response of the guinea-pig to nicotinic acid.


Interactions of catecholamines and adrenergic blocking agents at receptor sites mediating glycogenolysis in the rat.


Idiotypy of rabbit antibodies. I. Comparison of idiotypy of antibodies against Salmonella typhi with that of antibodies against other bacteria in the same rabbits, or of antibodies against Salmonella typhi in various rabbits. Sera of rabbits immunized against Salmonella typhi have been studied for the idiotypy of certain of their components, i.e., the property of these components to possess an antigenic specificity which is different in individual rabbits, and which varies with the antigens against which these rabbits have been immunized. The reagent used (precipitating anti-idiotypic sera) have been prepared by injecting rabbits with bacteria agglutinated by anti-S. typhi sera (immunizing sera) as was done in the first observations by the authors of the phenomenon in the rabbit. These first observations have been confirmed and extended. In contrast to allotypy, the anti-idiotypic sera precipitate the corresponding immunizing sera, but not the sera taken in the immunizing rabbits prior to their immunization against S. typhi, nor the immunizing sera absorbed with the somatic antigen of S. typhi, demonstrating that idiotypes are antibodies. The idiotypic specificities of the antibodies of one rabbit against S. typhi are not detected in the antibodies of the same rabbit against another noncross-reacting Salmonella (S. tranoroa) and vice versa; nor are they detected in the anti-pneumococcal antibodies of the same rabbit. Each anti-idiotypic serum fails to precipitate anti-S. typhi sera of rabbits other than the immunizing one except for certain extremely faint reactions, the significance of which has not been established. The idiotypic specificities of anti-S. typhi antibodies of three rabbits were not found in anti-S. typhi antibodies of their parents. This lack of a sign of hereditary transmission of idiotypic specificities contrasts with allotypy. The apparent role of random chance in the determinism of the idiotypic patterns or of the idiotypic determinants has been discussed. Unless it were admitted that antibodies with similar functions do not exist in different individuals, idiotypy apparently adds an order of magnitude to the antibody variability which had been previously envisaged. In one given individual, the heterogeneity of the idiotypic specificities seems to be less extended than that of the antibody functions. The possible relationships between these two levels of molecular variability and between the corresponding levels of cellular variability have been discussed.


The relation beween he bactericidal activities and certain physico-chemical properties of some fluorophenols.


An automated apparatus for dissolution studies.


Antituberculosis activity of some nitrofuran derivatives.


Structure-activity relations in analgesics based on 4-anilinopiperidine.


Methaemoglobin formation by aromatic amines.


The effect of anti-inflammatory drugs on the protein-binding of 11-hydroxysteroids in human plasma in vitro.


Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines.


Interaction between cerebral amines and 4-hydroxybur- ate in the induction of sleep.


Fluorimetric assay of methaqualone in plasma by reduction to 1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolylquinazoline.


Acetylcholine content in the brain of rats treated with paraoxon and pyridinium-2-aldoxime methylchloride.


Determination of dihydroxypropyltheophylline in plasma.


A technique for intrapleural cannulation in experimental animals.


Effect of temperature changes on the tone of perfused mesenteric arteries of rat and on the perfusion pressure responses to sympathetic nerve stimulation and injected noradrenaline.


Effect of aminophylline, butalamine and imolamine on human isolated smooth muscle.


Gas chromatographic evaluation of 5,5-dimethyl-2,4-oxazolidinedione (DMO) for determination of intracellular pH.


Protection against m-fluorotyrosine convulsions and lethality in mice exposed to hypobaric hypoxia.


Is there a simple explanation for the sensitization to histamine produced by adrenergic beta-receptor antagonists?


A clinical comparison of rectal pyrilamine maleate and trimethobenzamide hydrochloride for the control of vomiting in children.


Septicemia and disseminated intravascular coagulation. Occurrence in four asplenic children.


Computer interpretation of the MMPI. Its use in clinical practice.


Increased dihydrofolate reductase synthess in Diplococcus pneumoniae following translatable alteration of the structural gene. I. Genotype derivation and recombinational analyses.


Increased dihydrofolate reductase synthesis in Diplococcus pneumoniae following translatable alteration of the structural gene. II. Individual and dual effects on the properties and rate of synthesis of the enzyme.


Determination of mosquito hosts in salt marsh areas of Louisiana.


Studies on longevity of adult Eretmapodites chrysogaster, Aedes togoi and Aedes (Stegomyia) albopictus females (Diptera: Culicidae).


The alkaloids of Rauwolfia cumminsii Stapf (African Rauwolfia species. IX).


Expanding horizons in medical education. AAAS symposium--28 December 1969, Boston.


Laboratory evaluation of antiepileptic drugs. The use of chronic lesions.


Respiration in blue-green algae.

Respiration in blue-green algae. The low rate of endogenous respiration exhibited by the blue-green algae Anacystis nidulans and Phormidium luridum was not increased by the addition of respiratory substrates. However, endogenous respiration was inhibited by low concentrations of cyanide and by high carbon monoxide tensions. In addition, the uncouplers dinitrophenol and carbonyl cyanide p-trifluoromethoxyphenylhydrazone both stimulated the respiratory rate. The transition of cells from the aerobic steady state to anaerobiosis was accompanied by a decrease in the concentration of cellular nicotinamide adenine dinucleotide phosphate (NADP(+)) and adenosine triphosphate (ATP), whereas the concentration of nicotinamide adenine dinucleotide (NAD(+)) was unchanged. Concomitant with the metabolite decreases were stoichiometric increases io reduced NADP(+) (NADPH), adenosine diphosphate, and adenosine monophosphate. A decrease in ATP was also observed after the addition of uncouplers. These data are interpreted as evidence for the association of oxidative phosphorylation with the oxidation of NADP(+)-linked substrates in these algae. Membrane fragments isolated from the algal cells oxidized succinate, malate, ferrocytochrome c, ascorbate-tetramethyl-p-phenylenediamine, and reduced 2,6-dichlorophenol indophenol but did not oxidize NADPH or reduced NAD(+) in a cyanide-sensitive system. Oxidative phosphorylation has not yet been demonstrated in these fragments, but a dark ATP-P(i) exchange, distinct from the lighttriggered exchange associated with photosynthesis, is readily observed. This exchange was inhibited by phloridzin, Atabrine, and uncouplers in concentrations which suggest that the mechanism of oxidative phosphorylation in blue-green algae is different from that found in other bacteria and in mitochondria. These results led to the conclusion that the biochemical basis for obligate autotrophy in these organisms does not lie in the metabolic events associated with terminal electron transport and energy conservation.


Physico-organic chemical approach to the mode of action of organophosphorus insecticides.


Mechanisms of pesticide interactions in vertebrates.


Induction of tyrosine aminotransferase by D-glucosamine in rat hepatoma cell culture.


220 MHz proton nuclear magnetic resonance study of the geometric disposition of the base pairs in the oxidized and reduced pyridine nucleotides.


Purification and properties of sheep liver phosphofructokinase. 1. The activity of phosphofructokinase in sheep liver was found to be dependent on the composition and molarity of the buffer used in extraction. Under optimum conditions a value of 4-7mumoles/min./g. wet wt. of tissue was obtained. 2. The enzyme was purified 480-fold by a combination of ammonium sulphate fractionation, heat treatment in the presence of ethanol, DEAE-cellulose chromatography and Sephadex G-200 gel filtration. The final specific activity was 18.5mumoles/min./mg. of protein. 3. The purified enzyme was inhibited by ATP and citrate, the degree of inhibition depending on the concentration of fructose 6-phosphate, magnesium chloride and ammonium sulphate, as well as on the pH. ATP and citrate inhibition was overcome by AMP and fructose 1,6-diphosphate. 4. The enzyme was also inhibited by NADH and NADPH in a manner largely independent of other components of the assay medium. AMP and fructose 1,6-diphosphate were not able to overcome this type of inhibition. 5. Octanoate was not an inhibitor of phosphofructokinase. 6. Differences between these results and those of other workers are discussed.


Lipid peroxide formation in microsomes. The role of non-haem iron. 1. Metal ion-chelating agents such as EDTA, o-phenanthroline or desferrioxamine inhibit lipid peroxide formation when rat liver microsomes prepared from homogenates made in pure sucrose are incubated with ascorbate or NADPH. 2. Microsomes treated with metal ion-chelating agents do not form peroxide on incubation unless inorganic iron (Fe(2+) or Fe(3+)) in a low concentration is added subsequently. No other metal ion can replace inorganic iron adequately. 3. Microsomes prepared from sucrose homogenates containing EDTA (1mm) do not form lipid peroxide on incubation with ascorbate or NADPH unless Fe(2+) is added. Washing the microsomes with sucrose after preparation restores most of the capacity to form lipid peroxide. 4. Lipid peroxide formation in microsomes prepared from sucrose is stimulated to a small extent by inorganic iron but to a greater extent if adenine nucleotides, containing iron compounds as a contaminant, are added. 5. The iron contained in normal microsome preparations exists in haem and in non-haem forms. One non-haem component in which the iron may be linked to phosphate is considered to be essential for both the ascorbate system and NADPH system that catalyse lipid peroxidation in microsomes.


Lipid peroxide formation in microsomes. General considerations. 1. Liver microsomes form lipid peroxide when incubated with ascorbate or NADPH, but not with NADH. Increasing the concentration of ascorbate beyond the optimum (0.5mm) decreases the rate of lipid peroxide formation, but this effect does not occur with NADPH. Other reducing agents such as p-phenylenediamine or ferricyanide were not able to replace ascorbate and induce lipid peroxide formation. 2. The rate of ascorbate-induced peroxidation is optimum at pH6.0 whereas the rate of the NADPH system is optimum at pH7.0. Both systems require phosphate for maximum activity. 3. Lipid peroxide formation occurs at the maximum specific rate in very dilute microsome suspensions (0.15mg. of protein/ml.). 4. Treatment of microsomes with deoxycholate and other detergents causes membrane disintegration and inhibits lipid peroxide formation. 5. Lipid peroxide formation is accompanied by a rapid uptake of oxygen and there is a large excess of oxygen utilized for each molecule of malonaldehyde measured in the peroxide method. 6. Boiled microsomes form lipid peroxide in the presence of ascorbate, but not if NADPH is added. 7. Lipid peroxide formation induced by NADPH is strongly inhibited by p-chloromercuribenzoate, weakly inhibited by N-ethylmaleimide and unaffected by iodoacetamide. Ascorbate-induced peroxidation in untreated microsomes is unaffected by p-chloromercuribenzoate, but inhibited if boiled microsomes are used. These experiments may be interpreted on the basis that a ferredoxin-type protein forms part of the system in which NADPH induces lipid peroxide formation. 8. Most heavy-metal ions, with the exception of inorganic iron (Fe(2+) or Fe(3+)), which activates, inhibit both ascorbate-induced and NADPH-induced peroxidation. Mg(2+) increases the rate of peroxidation whereas Ca(2+) inhibits it. 9. Lipid peroxide formation is inhibited strongly by GSH and weakly by cysteine. Ascorbate-induced peroxidation is much more sensitive than NADPH-induced peroxidation. 10. Peroxidation is strongly inhibited by addition of low concentrations (0.01-0.1mm) of cytochrome c or of haemoglobin. 11. It is considered that lipid peroxide formation occurs as a result of the operation of the microsomal electron-transport chain switching from hydroxylation to oxidize unsaturated lipids of the endoplasmic reticulum.


Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation. 1. Aminopyrine strongly inhibits NADPH-induced lipid peroxide formation in rat liver microsomes, but ascorbate-induced peroxidation is inhibited to a smaller extent. 2. Aminopyrine oxidation is stimulated by Mg(2+) but inhibited by Ca(2+). Concentrated solutions (10mm) of iron-chelating agents inhibit aminopyrine oxidation, but the more dilute solutions (0.5mm) of chelators that block lipid peroxide formation do not inhibit aminopyrine oxidation. Microsomes prepared from sucrose-EDTA homogenates rapidly oxidize aminopyrine, but do not form lipid peroxide when incubated with ascorbate or NADPH. 3. Aminopyrine oxidation is strongly inhibited by p-chloromercuribenzoate, less by iodoacetamide and weakly by N-ethylmaleimide. The site of action of these compounds is considered to be a ferredoxin-type protein. GSH and cysteine also inhibit. 4. Other drugs oxidized by microsomes such as caffeine, phenobarbitone and hexobarbitone had either no or little effect on lipid peroxide formation, but codeine inhibited. 5. Most aliphatic hydrocarbons, alcohols, ketones and aldehydes did not affect lipid peroxide formation, but chloroform and carbon tetrachloride inhibited. 6. Many aromatic compounds inhibited lipid peroxide formation. Only aromatic acids were without any effect and phenols and amines were very strong inhibitors. 7. Induction of lipid peroxide formation in microsomes by incubation with ascorbate or NADPH or by treatment with ionizing radiation leads to a sharp decline in the ability of microsomes to oxidize aminopyrine or hydroxylate aniline. 8. It is considered that the two processes of hydroxylation and lipid peroxide formation are closely linked in microsomes. They probably depend on the same electron-transport chain, and peroxide formation, which involves membrane disintegration, may be part of the normal membrane remodelling process.


Metabolic control and structure of glycolytic enzymes. VI. Competitive inhibition of yeast glyceraldehyde 3-phosphate dehydrogenase by cyclic adenosine monophosphate, adenosine triphosphate, and other adenine-containing compounds.


Conversion of light into chemical free energy through chlorophyllin-sensitized photoreduction of oxidized nicotinamide-adenine dinucleotide phosphate by cytochrome c.


The side-chain cleavage of cholesterol and cholesterol sulfate by enzymes from bovine adrenocortical mitochondria.


Subfractionation and polyacrylamide gel analysis of liver ribonucleic acid from normal and glucocorticoid-treated rats.


Adenyl cyclase activity in particles from fat cells.


Regulation of tyrosine transaminase in the isolated perfused rat liver.


On the reactivity of the sulfhydryl groups of ferredoxin nicotinamide adenine dinucleotide phosphate reductase.


Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver.


Metabolism of cortisol by human leukemic cells.


Adrenergic receptor mediation of renin secretion.


The rate of dissolution of powdered griseofulvin at different stirring rates.


Steroid hormone binding to a macromolecule from hepatoma tissue culture cells.


The determination of bromisoval and carbromal in biological material.


Quantitative determination of physostigmine from aqueous solution.


Comparison of bromisoval and carbromal in the rat.


The binding of salicylate to plasma protein from several animal species.


The influence of ATP in brain extracts on the estimation of acetylcholine assayed on the frog rectus abdominis muscle.


Dopa-induced locomotor stimulation after inhibition of extracerebral decarboxylase.


The human platelet as a pharmacologic model for the adrenergic neuron. The uptake and release of norepinephrine.


The bronchodilator action of analeptics in the guinea-pig.


Interaction between histamine and monoamine oxidase inhibitors.


Possible oestrogenic and anti-androgenic effects in rats treated with the oral hypoglycaemic agents tolbutamide and acetohexamide.


Effect of various decarboxylase inhibitors on the cerebral metabolism of dihydroxyphenylalanine.


Influence of pretreatment with testosterone and nandrolone on the reactivity of guinea-pig isolated seminal vesicles to angiotensin and tyramine.


Metabolic effect of p-aminosalicylic acid on human erythrocytes.


Stabilization of erythrocyte membrane by non-steroianti-inflammatory drugs.


Inhibition of the noradrenaline uptake in guinea-pig vas deferens by continuous nerve stimulation.


The effect of chloral hydrate on the metabolism of ethanol in mice.


Changes of thirst threshold produced by chlorpromazine.


Inhibition of gastric acid secretion in the rat by synthetic prostaglandins.


Simple chromatography of cannabis constituents.


The association of some oxidoreductases with the red cell membrane.


On the chemical distinctions between cholinesterase and cholinoreceptor.


A study of the oedipus complex and neurotic symptoms in a non-psychiatric population.


Leukocyte function in chronic granulomatous disease of childhood. Studies on a seventeen year old boy.


Cryoprotectants--a new class of drugs.

Cryoprotectants--a new class of drugs.


Toxicity of ethanol-barbiturate mixtures.


A simple infrared spectrum retrieval system.


A comparison of the effects of (plus of minus)-propranolol and (plus)-propranolol in anaesthetized dogs; beta-receptor blocking and haemodynamic action.


Monoamine oxidase activities in tissues of thiamine-deficient rats.


The effect of anti-Parkinsonian drugs on oxotremorine-induced analgesia in mice.


The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [14C] amphetamine.


Decrease in homovanillic acid as evidence for dopamine receptor stimulation by apomorphine in the neostriatum of the rat.


The carvone and dillapiole content of dill fruits by gas chromatography without preliminary distillation.


Activation of pepsinogen by sulphated glycosaminoglycans: a possible role in peptic ulcerogenesis.


Amphetamine-induced release of [3H]metaraminol from subcellular fractions of the mouse heart.


The resistance of guinea-pigs to cortisone ulcerogenesis.


Prolonged oestrogenic activity in rats after single oral administration of ethinyloestradiol-3-cyclopentyl ether.


MMPI characteristics of difficult-to-manage federal penitentiary offenders.


Relationship between estimated occurrence and social desirability scale value of objective personality items.


Note on the position of the alcoholic in the therapeutic programme.


Some personality and attitudinal correlates of dogmatism.


Implications of Eysenck's criterion analysis for test construction: is the MMPI schizophrenia scale a criterion for schizophrenia?


MMPI personality characteristics of physical and social science students.


Further evidence regarding the R scale of the MMPI as a measure of acquiescence.


Test of the unimportance of particular item content using the HTP and the MMPI.


The biochemistry of long-chain, nonisoprenoid hydrocarbons. IV. Characteristics of synthesis by a cell-free preparation of Sarcina lutea.


A verandah-trap hut for studying the house-frequenting habits of mosquitoes and for assessing insecticides. 3. The effect of DDT on behavior and mortality.


Induced somatic reactions in asthmatic adults. (Their reduction by use of a psychotropic drug).


Oxidized triphosphopyridine nucleotide specific isocitrate dehydrogenase from Azotobacter vinelandii. Isolation and characterization.


Three types of delinquents: their performance on MMPI and PCR.


Learning to solve emotional problems: a controlled study of short-term anxiety-provoking psychotherapy.


Kinetics of the resolution of complex I (reduced diphosphopyridine nucleotide-coenzyme Q reductase) of the mitochondrial electron transport system by chaotropic agents.


MMPI rational subscales: a question of clinical utility.


What do MMPI zero items really measure: an experimental investigation.


Concurrent validity of MMPI alcoholism scales.


Adult norms at several age levels for Hovey's MMPI scale of CNS disorder.


Oxygen tension in testes of normal and cryptorchid rats.


The Similes Preference Inventory: the unsuccessful search for construct validity in a clinical setting.


The structure of the Marine benzofuran, furoventalene, a non-farnesyl sesquiterpene. Chemistry of coelenterates. XIV.


Detection of glucose-6-phosphate dehydrogenase by fluorescence after cellulose acetate electrophoresis.


The effect of alkyl substitution in drugs. XX. Some pharmacological investigations into a series of 1-(o-alkylphenyl)-2-methyl and 1-(o-alkylphenyl)-2-ethylcyclohexanols.


NAD+ induced nucleoside specificity of oxidative phosphorylation.


The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene.


Role of host RNA polymerase for lambda phage development.


Ethanol oxidation in the microsomal fraction of rat liver.


Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.


Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae.


Ferredoxin reducing substance (FRS) from spinach.


Stimulation of 3',5'-cyclic AMP formation in dog myocardium following arrest of blood flow.


Investigation of mixed function oxidation by means of chemiluminescence.


The nature of the enzymatic reduction of S-sulfoglutathione in liver and peas.


Enzymes of methylglyoxal metabolism in a Pseudomonad which rapidly metabolizes aminoacetone.


A pharmacological study of the toxin in a Cnidarian, Chironex fleckeri Southcott. 1. A study has been made of the pharmacological actions of toxic preparations obtained from the box jellyfish Chironex fleckeri Southcott. Two toxin preparations were used. One was a tentacle extract which was partially purified by Sephadex gel filtration; the second was obtained by a process analogous to snake milking, and is probably similar in composition to the material injected into victims.2. All preparations were extremely toxic; death in animals, following minimally lethal doses, occurred in minutes. Respiratory arrest of central origin appeared to be the terminal event in all species tested. This was accompanied by marked signs of cardiotoxicity. The heart was slowed, irregular, and showed varying degrees of conduction delay. Terminally it showed atrioventricular block.3. Blood pressure changes were biphasic. An initial rise in carotid pressure was followed by a profound fall; a second rise to an above normal level frequently followed this. These blood pressure oscillations were damped down by prior treatment with hexamethonium but the hypertensive response remained.4. Blood samples taken before terminal apnoea showed a variable degree of haemolysis and a raised K(+) level.5. Experiments with isolated organ preparations suggested that the toxin had a non-specific lytic effect on cells, but did not contain pharmacologically active substances of small molecular weight such as 5-hydroxytryptamine.6. It is suggested that the toxin(s) act by altering membrane permeability; the signs at death may reflect the sensitivity of the target organs to such a change.


The monoamine oxidase activity of the hamster gastrointestinal tract.


The influence of anesthesia on baroreceptor reflexes.


Effects of manipulation of biogenic amine levels upon spinal cord reflexes.


Anesthetic potency compared with intensity of effect on oxygen consumption in monolayer cultures.


A comparison of dehydrogenase activities in tissue homogenates and tissue sections.


A study of the metabolism of L-alpha gamma-diaminobutyric acid in a Xanthomonas species. 1. l-alphagamma-Diaminobutyric acid is metabolized in Xanthomonas sp. to aspartic beta-semialdehyde, aspartic acid and oxaloacetic acid. 2. Aspartic beta-semialdehyde is formed from diaminobutyric acid by a pyruvate-dependent gamma-transamination. 3. The transaminase has a pH optimum of 9 and exhibits a high degree of substrate specificity, as analogues of diaminobutyric acid and pyruvate are inert in the system. The transaminase is inhibited by carbonyl-binding agents such as hydroxylamine. 4. Aspartic acid is formed from aspartic beta-semialdehyde by an NAD(+)-dependent dehydrogenation. 5. The dehydrogenase has a pH optimum of 8.5 and is a thiol enzyme. It is specific for aspartic beta-semialdehyde but analogues of NAD(+) such as 3-acetylpyridine-adenine dinucleotide and deamino-NAD are partly active in the system. 6. The significance of these reactions is discussed in relation to diaminobutyric acid metabolism in plants and mammalian systems.


A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates. GSH added to rat liver homogenates inhibited respiration and increased GSSG formation approximately proportionally to the amount of GSH added; the effect was increased by added magnesium chloride. Added NADPH and citrate decreased GSSG formation and increased respiration; 6.0mm-nicotinamide prevented GSSG formation and increased respiration. There was a negative correlation between GSSG formation and oxygen uptake. It is suggested that the decrease in oxygen uptake is mainly due to GSSG concentration and also that in vivo a GSH-GSSG steady state occurs.


Destruction of reduced nicotinamide-adenine dinucleotide phosphate by bromotrichloromethane and by carbon tetrachloride in vitro and in vivo.


Th control of isocitrate oxidation by rat liver mitochondria. 1. The factors capable of affecting the rate of isocitrate oxidation in intact mitochondria include the rate of isocitrate penetration, the activity of the NAD-specific and NADP-specific isocitrate dehydrogenases, the activity of the transhydrogenase acting from NADPH to NAD(+), the rate of NADPH oxidation by the reductive synthesis of glutamate and the activity of the respiratory chain. A quantitative assessment of these factors was made in intact mitochondria. 2. The kinetic properties of the NAD-specific and NADP-specific isocitrate dehydrogenases extracted from rat liver mitochondria were examined. 3. The rate of isocitrate oxidation through the respiratory chain in mitochondria with coupled phosphorylation is approximately equal to the maximal of the NAD-specific isocitrate dehydrogenase but at least ten times as great as the transhydrogenase activity from NADPH to NAD(+). 4. It is concluded that the energy-dependent inhibition of isocitrate oxidation by palmitoylcarnitine oxidation is due to an inhibition of the NAD-specific isocitrate dehydrogenase. 5. Kinetic studies of NAD-specific isocitrate dehydrogenase demonstrated that its activity could be inhibited by one or more of the following: an increased reduction of mitochondrial NAD, an increased phosphorylation of mitochondrial adenine nucleotides or a fall in the mitochondrial isocitrate concentration. 6. Uncoupling agents stimulate isocitrate oxidation by an extent equal to the associated stimulation of transhydrogenation from NADPH to NAD(+). 7. A technique is described for continuously measuring with a carbon dioxide electrode the synthesis of glutamate from isocitrate and ammonia.


Control of the steady-state concentrations of the nicotinamide nucleotides in rat liver. 1. The effects of injecting nicotinamide, 5-methylnicotinamide, ethionine, nicotinamide+5-methylnicotinamide and nicotinamide+ethionine on concentrations in rat liver of NAD, NADP and ATP were investigated up to 5hr. after injection. 2. Nicotinamide induced three- to four-fold increases in hepatic NAD concentration even in the presence of 5-methylnicotinamide or ethionine, whereas 5-methylnicotinamide or ethionine alone did not cause marked changes in hepatic NAD concentration. 3. Nicotinamide alone also induced a twofold increase in hepatic NADP concentration. However, in the presence of 5-methylnicotinamide+nicotinamide, the NADP concentration decreased by 25% after 5hr., and in the presence of nicotinamide+ethionine by 30% in the same time. In the presence of 5-methylnicotinamide or ethionine alone hepatic NADP concentrations fell by 50% after 5hr. 4. 5-Methylnicotinamide inhibited the microsomal NAD(+) glycohydrolase (EC 3.2.2.6) by 60% at a concentration of 1mm and the NADP(+) glycohydrolase by 40% at the same concentration. 5. The rat liver NAD(+) kinase (EC 2.7.1.23) was found to have V(max.) 4.83mumoles/g. wet wt./hr. and K(m) (NAD(+)) 5.8mm. This enzyme was also inhibited by 5-methylnicotinamide in a ;mixed' fashion. 6. The results are discussed with respect to the control of NAD synthesis. It is suggested that in vivo the NAD(P)(+) glycohydrolases are effectively inactive and that the increased NAD concentrations induced by nicotinamide are due to increased substrate concentration available to both the nicotinamide and nicotinic acid pathways of NAD formation.


Th biosynthesis of rubber from beta-hydroxy-beta-methylgluarylcoenzyme A in Hevea brasiliensis latex. 1. beta-Hydroxy-beta-methyl[3-(14)C]glutaryl-CoA is efficiently incorporated into rubber on incubation with Hevea brasiliensis latex, and the incorporation is diminished in the presence of unlabelled mevalonate. beta-Hydroxy-beta-methylglutaric acid is not utilized for rubber synthesis, but inhibits the formation of rubber from beta-hydroxy-beta-methylglutaryl-CoA. 2. The incorporation of beta-hydroxy-beta-methylglutaryl-CoA into rubber is stimulated equally by NADP(+) and NADPH and less so by NAD(+) and NADH. ATP is slightly stimulatory and CoA is inhibitory. 3. beta-Hydroxy-beta-methylglutaryl-CoA reductase is concentrated in the sediment (bottom fraction) formed by centrifuging latex at low speed and the enzyme is unstable in the absence of cysteine or GSH. The formation of NADPH takes place in the latex serum. 4. There is a marked seasonal variation in the extent of beta-hydroxy-beta-methylglutaryl-CoA incorporation into rubber in latex, but mevalonate incorporation is relatively constant. This observation, together with the finding that beta-hydroxy-beta-methylglutaryl-CoA reduction is the rate-limiting step in the formation of rubber from beta-hydroxy-beta-methylglutaryl-CoA, suggests that the conversion of beta-hydroxy-beta-methylglutaryl-CoA into mevalonate is of importance in the regulation of rubber synthesis. 5. Evidence suggesting that beta-hydroxy-beta-methylglutaryl-CoA lyase is present in H. brasiliensis latex has been obtained.


A mapping procedure for the geographic pathology of dental caries.


Abnormal sex chromatin pattern in cryptorchidism, girls with short stature and other endocrine patients.


In vitro evaluation of a series of sympathomimetic amines and the beta-adrenergic blocking properties of cyclopentamine.


Pharmacology for the dental practitioner. 4. Unwanted effects due to drugs (continued).


Ego measurements of patients and staff on a medical ward.


Frequency of tooth loss in relation to the dentist's ability to prevent the necessity of extraction.


Extreme response tendency as a function of emotional adjustment and stimulus ambiguity.


Personality factors related to response to social isolation and confinement.


Suicide and natural death in a state hospital population: a comparison of admission complaints, MMPI profiles, and social competence factors.


Internal-external control dimension as related to accident and suicide proneness.


Ideal-self responding on the MMPI.

Ideal-self responding on the MMPI.


Comparison of Negro and white lower class men on the general aptitude testattery and the Minnesota Multiphasic Personality Inventory.


Development of a laboratory model gas analyzer using emission techniques. MRL-TR-68-130.


Functional verification of the Apollo urine transport system. AMRL-TR-67-166.


Toxic Hazards Research Unit annual technical report: 1968. AMRL-TR-68-133.


Bacteria sensor for reprocessed water--microbiological research, design, and fabrication. AMRL-TR-68-173.


Unique altitude chamber for infectious disease research under aerospace profiles. SAM-TR-68-94.


The anorexia nervosa syndrome: phenomenologic and psychodynamic components. Clinical heterogeneity in four cases.


The flammability of skin and hair in oxygen-enriched atmospheres. SAM-TR-68-130.


Drug and toxic hazrds in general aviation. AM-68-16.


Observations of intra-ocular pressure changes during an FBM patrol as measured by Schiotz tonometry. Rep No 554.


Performance effects of increased ambient pressure. I. Helium-oxygen saturation and excursion dive to a simulated depth of 900 feet. Rep No 556.


The intelligibility of helium-speech as a function of speech-to-noise ratio. Rep No. 555.


Arbovirus studies in the Ohio-Mississippi Basin, 1964-1967. I. Introduction.


Enzymes of glucose catabolism in hydra. I. Relative activities of enzymes and absence of 6-phosphogluconate dehydrogenase.


Enzymes of glucose catabolism in hydra. II. Application of microfluorometric analyses to patterns of enzyme localization.


The mechanism of photosynthetic sulfate reduction by isolated chloroplasts.


Electron transfer components of wild-type and photosynthetic mutant strains of Scenedesmus obliquus  D3.


Further studies on corticosteroidogenesis. VI. Pyruvate and malate supported steroid 11-beta-hydroxylation in rat adrenal gland mitochondria.


m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger.


Antigen development in submicrosomal fractions of rat liver.


Preiminary investigation of the pharmacology of the human internal anal sphincter. The smooth muscle from the human internal anal sphincter has been investigated pharmacologically in vitro. The upper and lower parts of the sphincter responded to catecholamines in a similar manner. Noradrenaline caused contraction which could be antagonized by phenoxybenzamine. After phenoxybenzamine, noradrenaline caused relaxation which could be blocked by pronethalol. Isoprenaline caused relaxation which could be specifically prevented by pronethalol. Adrenaline was variable in its effect: low concentrations caused relaxation and high concentrations caused contraction. It is suggested that the anal smooth muscle contains alpha-adrenergic receptors subserving contraction and beta-receptors subserving relaxation. The lower part of the sphincter was generally insensitive to acetylcholine and nicotine whereas the upper part of the sphincter contracted with acetylcholine and regularly relaxed with nicotine. The nicotine response was antagonized by hexamethonium, procaine, and pronethalol. It is suggested that nicotine stimulated some part of the nervous mechanism in the upper part of the sphincter and that a catecholamine was the mediator of the inhibitory response.


Histochemical study of oxidative enzymes and cysteine desulfurase in familiar benign chronic pemphigus and Darier's disease.


Biological activity of megalomicin, a new Micromonospora-produced macrolide antibiotic complex.


Microchemical investigation of medicinal plants. VI. Estimation of reserpine and rescinnamine in Rauwolfia.


Heterogeneity of the enzymatic defect in congenital methemoglobinemia.


Enhancement of rat liver microsomal oxidases by magnesium and a heat-stable factor from the soluble fraction.


Distribution and metabolism of norepinephrine after its administration into the cerebroventricular system of the cat.


Effect of analeptics on brain pentobarbital levels and sleeping time in mice.


Effect of tranquillizer drugs on liver tyrosine-alpha-ketoglutarate transaminase activity.


Pharyngeal edema associated with arteritis. A report of two cases.


Correlates of empathy in psychotherapy: a replication.


Drugs for cardiac arrhythmias. II.

Drugs for cardiac arrhythmias. II.


EEG activation with Dimefline hydrochloride.


The cost of anesthesia with fluorinated volatile anesthetic agents.


Invertebrate collagens: isolation, characterization and phylogenetic aspects.


Who seeks treatment? A study of psychiatrically disabled veterans.


Antibiotic penetration of the brain. A comparative study.


The clinical utility of Block's ego-resiliency and ego-control scales.


The nasal flora of Australian aboriginals of the Pitjantjatjara tribe.


3',5'-cyclic AMP and the adrenal desmolase system.


The chemical composition of sea nettle nematocysts.


Dentists and their meetings.

Dentists and their meetings.


Seminar on dental education. Speech by the Deputy Prime Minister.


Dental health of preschool children.

Dental health of preschool children.


Focus on the future.

Focus on the future.


A pre-fluoridation survey in Asheville, North Carolina.


A histochemical study of the effect of estrogen on oxidative enzymes in the testes of cryptorchid BALB/c mice.


Effect of cyclic 3',5'-AMP on glucose metabolism in thyroid homogenates.


Experimental studies of shift-work. II. Stabilized 8-hour shift systems.


Lincomycin. 8. 4'-Alkyl-1'-demethyl-4'-depropylclindamycins, potent antibacterial and antimalarial agents.


A physicochemical model for the mechanism of action of antihistaminics and cortisol.


Bicyclic homologs of piperazine. IX. Synthesis and pharmacological properties of phenothiazine and of 10,11-dihydrodibenzocycloheptene derivatives of 3,8-diazabicyclo[3.2.1]octanes.


A new genus and species of mosquito from Colombia, Galindomyia leei (Diptera, Culicidae, Culicini).


The importance of endogenous catecholamines in the activity of some CNS stimulants.


Mechanism of action of antihistamines in laboratory antidepressant tests.


Foreign medical scholars and American medical education.


Cutaneous neurohormones.

Cutaneous neurohormones.


Molecular sieve studies of interacting protein systems. V. Association of subunits of D-amino acid oxidase apoenzyme.


Homoserine dehydrogenase of escherichia coli K 12 lambda. I. Feedback inhibition by L-threonine and activation by potassium ions.


Epidemiology of western encephalitis in Alberta: response of natural populations of mosquitoes to avian host.


Interaction between phenylpropanolamine and monoamine oxidase inhibitors.


The in vitro and in vivo metabolism of optically active methylcyclohexanols and methylcyclohexanones.


The evaluation of inflammation induced by material implanted subcutaneously in the rat.


The effects of 1-[di(2-chloroethyl)amino-methyl]benzimidazole and related compounds on the growth of experimental tumours.


The determination of the binding of salicylate to serum proteins.


The effect of ultrasonic energy on the extraction of anthraquinones from senna pericarps.


Calibration and application of high torques to a reaction air turbine viscometer.


The diffusion of sennoside A through a cellulose membrane.


Peripheral factors in the mediation of the effects of L-dopa on locomotor activity.


The effect of purity on the surface tension behaviour of a homogeneous non-ionic detergent.


Quantitative analysis of 4'-chloro-2-ethyl-aminopropiophenone, 4'-chloro-2-amino-propiophenone and the corresponding amino-alcohols in a mixture of the four compounds.


Micellar polydispersity of the non-ironic detergent cetomacrogol.


Effect of tyramine and octopamine on lipolysis in isolated fat cells of the rat.


Effect of capsaicin on the guinea-pig isolated atrium.


Relative blocking effectiveness of propranolol and of practalol [4-(2-hydroxy-3-isopropylaminopropoxy) acetanilide] on isoprenaline in beta-1 receptor mediated calorigenesis.


The potency of heparin fractions obtained by gel filtration.


A use of the isomeric ratio as a criterion to differentiate adrenergic receptors.


The analgesic and respiratory depressant activities of N-allyl noretrophine and morphine in the mouse.


An improved method of filtration in the determination of morphine by precipitation with fluorodinitrobenzene.


2-Alphahydroxysteroid dehydrogenase and reductive metabolism of progesterone in mammalian cell cultures.


The role of mixed function oxidases in kaurene metabolism in Echinocystis macrocarpa Greene endosperm.


NADH-dependent synthesis of butyric acid by rabbit mammary gland mitochondrial enzymes.


Inhibitors of the catalytic activity of bovine adrenal glucose-6-phosphate dehydrogenase.


Atropine inhibition of insulin-, histamine-, and pentagastrin-stimulated gastric electrolyte and pepsin secretion in the dog.


Selection of anesthesia.

Selection of anesthesia.


Characteristics of patients with hallucinations.


Effect of extent of temporal lobe surgery and neuropathology on the MMPI.


Clinical normative data for MMPI special scales: critical items, manifest anxiety, and repression-sensitization.


MMPI two-point code-type correlates in a state hospital population.


Utility of MMPI "cookbooks".

Utility of MMPI "cookbooks".


A comparison of two MMPI actuarial systems used in classifying an alcoholic out-patient population.


A comparison of oral and booklet forms of the MMPI for psychiatric inpatients.


The ego strength scale and the Goldberg scale in evaluating clinic outpatients.


Prediction of length of hospital stay from MMPI scales.


Epidemiologic features of diffuse connective tissue disorders in Rochester, Minn., 1951 through 1967, with special reference to systemic lupus erythematosus.


New method for assay of tyrosine transaminase.


A fluorometric procedure for estimation of galactose-1-phosphate uridylyltransferase activity in red blood cells.


Discouraging drug abuse.

Discouraging drug abuse.


Effects of adenosine phosphates and nicotinamide nucleotides on pyruvate carboxylase from baker's yeast. 1. Pyruvate carboxylase from baker's yeast is inhibited by ADP, AMP and adenosine at pH8.0 in the presence of magnesium chloride concentrations equal to or higher than the ATP concentration. The adenine moiety is essential for the inhibitory effect. 2. In the absence of acetyl-CoA (an allosteric activator) ADP, AMP and adenosine are competitive inhibitors with respect to ATP. In the presence of acetyl-CoA, besides the effect with respect to ATP, AMP competes with acetyl-CoA, whereas ADP and adenosine are non-competitive inhibitors with respect to the activator. 3. Pyruvate carboxylase is inhibited by NADH. The inhibition is competitive with respect to acetyl-CoA and specific with respect to NADH, since NAD(+), NADP(+) and NADPH do not affect the enzyme activity. In the absence of acetyl-CoA, NAD(+), NADH, NADP(+) and NADPH do not inhibit pyruvate carboxylase. 4. Pyruvate carboxylase is inhibited by ADP, AMP and NADH at pH6.5, in the presence of 12mm-Mg(2+), 0.75mm-Mn(2+) and 0.5mm-ATP, medium conditions similar to those existing inside the yeast cell. The ADP and NADH effects are consistent with a regulation of enzyme activity by the intracellular [ATP]/[ADP] ratio and secondarily by NADH concentration. These mechanisms would supplement the already known control of yeast pyruvate carboxylase by acetyl-CoA and l-aspartate. Inhibition by AMP is less marked and its physiological role is perhaps limited.


Production of diiodohydroxyphenylpyruvic acid from diiodotyrosine by nonenzymatic reaction.


5-HT autopotentiation and drug induced changes in the 5-HT vasomotor response in the pithed rat.


Action of central nervous system stimulant and depressant drugs in the intact animal. 4. Surface activity of drugs with central stimulant depressant, or dual stimulant-depressant action.


The inhibitory effect of convulsant agents on the enzyme in brain which inactivates nerveside. 1. An enzyme which can be extracted from brain inactivates nerveside in the optimum pH range 5.8-7.0.2. The polybasic acids trypan blue and its analogue trypan red, bromphenol blue and its analogue bromthymol blue at concentrations of 0.22 mM and ethylenediaminetetra-acetic acid (EDTA) at a concentration of 1 mM are strong inhibitors of the enzyme.3. Penicillin which is a monobasic carboxylic acid also inhibits the enzyme but only if concentrations as high as 3.6 mM are used. The antibiotic streptomycin which is a basic substance does not inhibit the enzyme.4. Caffeine at a concentration of 7.2 mM only weakly inhibits the enzyme.5. Chymotrypsin and wheat germ acid phosphatase also inactivate nerveside at pH 5.9 and are inhibited by the acidic dyes and penicillin. EDTA inhibits wheat germ phosphatase but activates chymotrypsin.6. Inactivation of nerveside by the brain enzyme and by wheat germ phosphatase is different from the action of chymotrypsin. Nerveside solutions incubated with chymotrypsin completely lose all biological activity whereas if incubation is carried out with either the brain enzyme or wheat germ acid phosphatase a residual biological activity remains even when the concentration of these two enzymes is increased. This residual biological activity is due to a peptide as it is destroyed by chymotrypsin.7. The manner in which nerveside is inactivated by the brain enzyme is uncertain as the preparation of the latter contained phosphodiesterase and protease activities which were similarly inhibited by the acid dyes, penicillin and EDTA.8. Pentylenetetrazole, picrotoxin, strychnine and tetanus toxin do not inhibit the brain enzyme.9. The nerveside-inactivating enzyme is not identical with the Substance P-inactivating enzyme in brain as the former is inhibited by EDTA while the latter is not.


Nervous and humoral influences on the blood flow response of brown adipose tissue to cold in the rat.


Phenolic acids in experimental uremia. II. Relationship of phenolic acid structure to seizure threshold in uremia.


Post-vaccinial complications. Report of 45 cases.


Brain damage, schizophrenia and five MMPI scales.


NADH and AMP as allosteric effectors of ribulose-5-phosphate kinase in Rhodopseudomonas spheroides.


TPNH and pyridoxal-5'-phosphate: activators of ADP-glucose pyrophosphorylase of Escherichia coli B1.


Oleic acid synthesis by a particulate preparation from developing castor oil seeds.


Activation by manganese of photochemical oxygen evolution and NADP+ photoreduction in chloroplasts.


Studies on the three photosynthetic mutants of Scenedesmus.


Metabolism and mechanism of action of oestrogens. XII. Structure and mechanism of formation of water-soluble and protein-bound metabolites of oestrone in rat-liver microsomes in vitro and in  vivo.


Antimycin A as an uncoupler and electron transport inhibitor in photoreactions of chloroplasts.


Galactolipid transformations and photochemical activities of spinach chloroplasts.


Immunologic factors involved in the growth of primary tumors in human or animal hosts.


Some enzyme patterns of Morris hepatoma 9618A under controlled feeding schedules.


Structural feature of Pneumococcus type XIX specific polysaccharide.


Hypertrophied non-failing rat heart; partial biochemical characterization.


Relation of pulmonary arterial pressure to pressure in the pulmonary venous system.


Observations on the sporogonic cycle and transmission of Plasmodium simium Da Fonseca.


Abnormal regulation of adenosine 3',5'-monophosphate and corticosterone formation in an adrenocortical carcinoma. A spontaneously occurring rat adrenocortical carcinoma which produces corticosterone was maintained by transplantation. The carcinoma appeared to utilize corticosterone biosynthetic steps similar to those of the normal adrenal, but the tumor produced only about 1-10% as much corticosterone per unit tissue weight as nontumorous adrenal glands. The tumor demonstrated little or no increase in corticosterone production in response to adrenocorticotropic hormone (ACTH) either in vivo or in vitro. In normal adrenals, ACTH increases the activity of adenyl cyclase which catalyzes the conversion of adenosine triphosphate (ATP) to adenosine-3',5'-monophosphate (cyclic AMP), the latter then serving as an intracellular regulator of steroidogenesis. ACTH failed to increase cyclic AMP levels in the tumor in vivo or in slices in vitro, conditions under which there were 50- and 20-fold increases in nontumorous adrenals. However, in homogenates fortified with exogenous ATP, adenyl cyclase activity was comparable in the tumor and adrenals, and cyclic AMP formation was increased 3-fold by ACTH in each. As measured in homogenates, the tumor did not possess a greater ability to destroy cyclic AMP than did normal adrenals. Although ATP levels in the carcinoma were found to be considerably lower than those in normal adrenals, it was not clear that this finding can explain the inability of ACTH to increase cyclic AMP levels in intact tumor cells. While the failure to normally influence cyclic AMP levels in the carcinoma cells could be an important factor in the lack of a steroid response to ACTH, several lines of evidence suggest that the tumor possesses one or more additional abnormalities in the regulation of steroidogenesis. First, in the absence of ACTH stimulation, the tissue concentrations of cyclic AMP were comparable in the tumor and in nontumorous adrenals, but these cyclic AMP levels were associated with a lower level of steroidogenesis in the tumor. Second, tumor slices failed to increase corticosterone production when incubated with cyclic AMP, in contrast to 5-fold increases observed with nontumorous adrenals.


A light and electron microscopic study of nematocytes of Chrysaora quinquecirrha.


Salivary thiocyanate secretion during a fleet ballistic missile submarine patrol. 561.


The distribution of cinnarizine and its metabolites in the rat.


The treatment of lobotomized schizophrenic patients with butaperazine.


Codeine and its alternates for pain and cough relief . 4. Potential alternates for cough relief. In this report-the fourth of a series on codeine and its alternates for pain and cough relief-an attempt is made to evaluate, on the basis of experimental and clinical data, and wherever possible in comparison with codeine, the effectiveness of a number of antitussive substances currently in clinical use. In the discussion of the undesired side-effects particular attention is paid to the risk of dependence and abuse.


Pheochromocytoma with predominant epinephrine secretion.


The amino acid composition of the subunit of the NADP-specific glutamate dehydrogenase from Neurospora crassa.


Pneumolysin and antipneumolysin.

Pneumolysin and antipneumolysin.


Preparation of semisynthetic coumermycin A1 derivatives. 3. Aromatic and heteroaromatic derivatives of 3-amino-4-hydroxy-8-methyl-7-[3-O-(5-methyl-2-pyrrolylcarbonyl) noviosyloxy]coumarin.


The ontogeny of interstitial cells in Pennaria tiarella.


Inhibition of hydroid aging in Campanularia flexuosa. Hydranths of the colonial marine hydroid Campanularia flexuosa (phylum Cnidaria, class Hydrozoa, order Calyptoblastea) have a mean life span of approximately 7 days in intact colonies in culture. Hydranths then regress and are absorbed, and their cellular materials are utilized by the colony for continued growth. Hydranth life spans can be extended to 20 days in isolated hydranths if, repeatedly, the pedicel is damaged by pinching and is allowed to partially regen-erate. This suggests that tissue damage and reorganization function to maintain the hydranth.


Increased enzyme activity in vitro and metabolism of substrates in vivo.


Effect of the venom of the black widow spider, Latrodectus mactans tredecimguttatus, on evoked action potentials in the isolated nerve cord of Periplaneta americana.


Acid polysaccharides from invertebrate connective tissue: phylogenetic aspects. Polyfucose sulfate and a chondroitin sulfate were isolated from echinoderm connective tissue. Coelenterate and poriferan connective tissues were devoid of these acid polysaccharides.


Poisoning by the medusa Gonionemus vertens in the sea of Japan.


Chromatographic properties of the hemolysin from the cnidarian Chironex fleckeri.


Year-long medico-engineering experiment in a partially closed ecological system.


Decompression sickness in simulated Apollo space-cabins.


Induction of tyrosine aminotransferase in isolated liver cells.


Inhibition of glucose-6-phosphate dehydrogenase from Ehrlich ascites carcinoma by ATP.


The subunits of porcine heart TPN-linked isocitrate dehydrogenase.


Isolation and purification of the isocitrate dehydrogenase (NADP+) of Azotobacter vinelandii.


Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation.


Free energy of cell differentiation.

Free energy of cell differentiation.


The effects of various pharmacological agents on the distribution of antihistamine activity of rat tissue extracts.


President's report to members.

President's report to members.


Further studies on the brown fat tissue and thyroid gland in the bat.


Inhibition of estrogen-induced elevation of cyclic 3',5'-adenosine monophosphate in rat uterus. I. By beta-adrenergic receptor-blocking drugs.


Studies on the mechanism of nitro reduction by rat liver.


Cardiovascular manifestations due to hypersensitivity.


Genes and isozymes.

Genes and isozymes.


Mechanical properties of insect fibrillar muscle at large amplitudes of oscillation.


Uptake and re-use of sympathetic transmitter in the cat's spleen.


Diaphorases and dehydrogenases in the muscle of the adult chicken.


Hypersensitivity and the lung.

Hypersensitivity and the lung.


A chloroplast cytoplasmic shuttle and the reduction of extraplastid NAD.


The distribution of polyol: NADP oxidoreductase in mammalian tissues.


Increased incidence of urethan-induced lung adenomas in neonatally thymectmized mice challenged with lymphoid cells.


Current trends in hepatic response tests.


Hypertensive pulmonary arteritis.

Hypertensive pulmonary arteritis.


Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients. Pituitary and gonadal function was studied in seven chromatin-negative men, ages 15-27 yr, with retarded sexual and somatic development, skeletal anomalies, and hyposmia. These hyposmic patients were compared with normal men, prepuberal boys and hypogonadal patients with hypopituitarism. The urinary follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels of hyposmic subjects were the same as those of normal boys and hypopituitary patients but significantly lower than those of normal men. Clomiphene citrate did not cause an increase in plasma FSH and LH levels in either hypogonadal group as it does in normal men. In contrast to hypopituitary patients, thyroid and adrenocortical function and release of growth hormone in the hyposmic subjects were normal. The plasma testosterone levels were equally low in prepuberal, hypopituitary, and hyposmic patients but were increased to a greater extent by human chorionic gonadotropin (HCG) treatment in prepuberal and hypopituitary subjects than in the hyposmic patients. Prolonged treatment with HCG has failed to return plasma testosterone levels to normal in two hyposmic patients. These observations suggest that there are defects of both pituitary and Leydig cell function in men with the syndrome of hypogonadism, skeletal anomalies, and hyposmia. They have impaired secretion of FSH and LH and a Leydig cell insensitivity to gonadotropin.


Pressor effects of neurohypophysial peptides in the eel, Anguilla anguilla L., with some reference to their interaction with adrenergic and cholinergic receptors.


The use of insect suction traps for sampling mosquitoes.


Heart rate and its neural regulation with rising body temperature in anesthetized rats.


Late contraction of nictitating membrane of the dog.


National conference on breast cancer, Washington, D. C., May 8-10, 1969.


Studies of the host response to infectious disease: alterations of RNA metabolism in mouse tissues.


The effect of calcium depletion on the combination of agonists and competitive antagonists with alpha adrenergic and histaminergic receptors of rabbit aorta.


Metabolic effects of ethanol in perfused rat liver.


Enzymatic studies in a case of hereditary tyrosinemia with hepatoma.


Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice. 1. The ganglion blocking agents, chlorisondamine, pentamethonium, mecamylamine, decamethonium and hexamethonium all block nicotine extensor convulsions when administered intraventricularly in mice. Tetraethylammonium was inactive.2. For the intraventricular route, there is a relationship between ganglionic blocking potency and blocking of nicotine extensor convulsions. Indirect evidence suggests that the site(s) of action of nicotine extensor convulsions and lethality is central in origin and associated with brain areas near the ventricles.3. When ganglion blocking agents are given orally, subcutaneously or intravenously varying degrees of protection can be observed probably depending on factors such as whether or not the drugs cross the blood-brain barrier, absorption, etc., and the effectiveness in protecting mice from nicotine is not related to ganglionic blocking potency.4. Atropine and morphine given intraventricularly or subcutaneously did not protect mice from the LD95 of nicotine. Chlorpromazine gave very erratic results and phenobarbitone was effective subcutaneously and to a lesser extent intraventricularly.


Further evidence for the involvement of kinin in anaphylactic shock in the rat. 1. Sodium phenylbutazone, soya bean trypsin inhibitor, or the concomitant administration of ascorbic acid and mepyramine protected rats against anaphylactic shock at 10 days after sensitization but gave no protection against anaphylaxis at 20 days.2. During anaphylactic shock in rats at 10 days after sensitization, the plasma bradykinin and bradykininogen levels, as well as those in the intestinal lumen and peritoneal cavity, were markedly raised.3. The results support the hypothesis that there are two phases in anaphylaxis in the rat-an early phase in which bradykinin is a mediator and against which phenylbutazone or soya bean trypsin inhibitor or the mixture of ascorbic acid and mepyramine, give protection, and a late phase which does not involve bradykinin.


The action of glucosulphone [N,N'-di (glucose sodium sulphonate) of 4,4'-diaminodiphenyl sulphone] on pancreatic kallikrein. 1. The effects of sulphone have been studied on kinin production in dog plasma and on capillary permeability in the skin of rabbits.2. Dog plasma was used as a substrate for pancreatic kallikrein in vitro and the addition of sulphone caused an inhibition of kinin production, which was dependent on the concentration of the drug.3. The increased vascular permeability produced in vivo by intradermal injections of kallikrein was partially inhibited by sulphone injected intravenously. The same doses of sulphone also inhibited the increase in permeability produced by bradykinin and histamine in the skin of rabbits.


The action of eledoisin on the peristaltic reflex of guinea-pig isolated ileum. 1. Low concentrations of eledoisin, acting from the serosal surface of the guinea-pig isolated ileum, had no effect on the peristaltic reflex, whereas in high concentrations it depressed or sometimes abolished this reflex.2. Eledoisin stimulated the peristaltic activity of the guinea-pig ileum subjected to continuously raised intraluminal pressure. This stimulatory effect could be produced regularly when the interval between additions of eledoisin was at least 20 min. When added at shorter intervals, tachyphylaxis to eledoisin developed, but its ability to promote peristaltic activity was restored by the addition of an anticholinesterase to the bath fluid. During tachyphylaxis to eledoisin, nicotine and dimethylphenylpiperazinium were unable to restore peristalsis.3. When the peristaltic reflex had been abolished by ganglion-blocking agents, morphine and morphine-like substances, or adrenaline, eledoisin restored the reflex. Eledoisin was much more effective in overcoming the blocking effect of hexamethonium, tetraethylammonium and azamethonium than that of nicotine or dimethylphenylpiperazinium.4. Eledoisin did not antagonize the inhibitory effects of atropine, hyoscine and hyoscine butylbromide.5. It is suggested that the stimulant effect of eledoisin may be due to a direct action on the smooth muscle and a release of acetylcholine from postganglionic nerve endings, but an effect on the intestinal ganglion cells cannot be excluded.


Stimulant action of tetraethylammonium on the peristaltic reflex of the guinea-pig isolated ileum. 1. Tetraethylammonium (TEA) in concentrations below 0.5 mg/ml. depressed or blocked the peristaltic reflex of the guinea-pig isolated ileum: in concentrations above 0.5 mg/ml. it caused a contraction of the longitudinal muscle and restored the peristaltic reflex previously blocked by the lower concentrations.2. The peristaltic reflex, when blocked by ganglion-blocking agents, morphine and morphine-like agents, 5-hydroxytryptamine, catecholamines or atropine, was restored by high concentrations of TEA.3. The possible mechanisms of these effects are discussed.


Factors involved in maintenance of cardiac catecholamine content: relative importance of synthesis and re-uptake. 1. When animals were exposed to a temperature of 4 degrees C for 6 hr, endogenous catecholamines remained unaltered or reduced slightly depending upon the strain of rats used. In contrast, labelled noradrenaline declined rapidly, but the decline was inhibited when animals were pretreated with monoamine oxidase inhibitors.2. Increased sympathetic nervous activity associated with cold resulted in a four-fold increase in rate of synthesis of noradrenaline.3. Reduction in endogenous and labelled catecholamine levels associated with cold was exaggerated by pretreatment with cocaine, imipramine or phenoxybenzamine-drugs known to inhibit the uptake of noradrenaline into the nerve terminal.4. Cocaine and imipramine in higher doses inhibited the release of both endogenous and labelled noradrenaline, suggesting a dual action: in small doses they increased the depletion of catecholamines by blocking the reincorporation, while in higher doses they inhibited the release of noradrenaline.5. It is concluded that, under normal conditions, the re-uptake mechanism may not play a significant role in the maintenance of normal cardiac catecholamine levels and that such levels are maintained by synthesis alone. However, when the heart is subjected to high impulse nerve activity, synthesis is not sufficiently accelerated to compensate for impulse-induced massive release and may require the support of an additional mechanism, such as the partial reincorporation of released transmitter. In fact, the re-uptake mechanism is enhanced during high impulse activity.


Actions of phenylephrine on beta-adrenoceptors in guinea-pig trachea. 1. Phenylephrine produced relaxation of the isolated guinea-pig tracheal chain preparation, its potency being 1/5 that of noradrenaline on normal tissues.2. The potentiation of phenylephrine by cocaine (10(-5)M) was only slight. Thus on cocaine-treated tissues phenylephrine was 1/45 as potent as noradrenaline.3. The dose-response lines to phenylephrine were shifted in a parallel manner by propranolol 10(-8)M and 10(-7)M, suggesting that the relaxations were mediated through beta-adrenoceptors.4. Phenylephrine had a lower intrinsic activity than the catecholamines and produced multiphasic dose-response lines at the higher doses used in the presence of propranolol (10(-6)M). These observations have been explained by the evidence obtained that phenylephrine is a partial agonist with beta-adrenoceptor blocking activity.5. From experiments using alpha-adrenoceptor blocking drugs, it has been concluded that stimulation of alpha-adrenoceptors has little influence on the beta-adrenoceptor relaxation to phenylephrine on the guinea-pig tracheal chain preparation.


Dependence on a placebo: a case report.

Dependence on a placebo: a case report.


Immunocompetence of spleen cells from neonatally thymectomized mice conferred in vitro by a syngeneic thymus extract. Impaired immunological competence of spleen cells from neonatally thymectomized C57B1/6 young adult mice was apparent when these cells were tested in an in vitro graft-versus-host assay. Spleen cell inocula prepared from thymectomized mice did not induce enlargement of (C3H/eb x C57BI/6)F(1) newborn spleen explants, whereas the same number of cells from intact donors consistently initiated splenomegaly. Spleen enlargement was observed, however, when the explants were challenged by cells from thymectomized donors in the presence of syngeneic thymus extract, indicating that the spleen cells in suspension attained immunological competence under the influence of a non-cellular component of the thymus. Immunocompetence was also evident when the cells from thymectomized donors were first incubated with thymus extract for 1 hr and subsequently tested for reactivity. Cells from the same thymectomized donor mice exposed in parallel to extracts from syngeneic spleen or mesenteric lymph node at an equivalent protein concentration did not initiate a graft-versus-host response. These experiments demonstrate that immune reactivity in the graft-versus-host response involves activation of lymphoid cells by a humoral factor of the thymus acting directly upon these cells.


Vascularization of the testis with ileal seromuscular grafts.


The pharmacology of the cholinoceptor in muscle preparations of Ascaris lumbricoides var. suum. 1. The preparation of a muscle strip of Ascaris lumbricoides for the study of the effect of drugs in vitro is described.2. Stimulant drugs which are classified as nicotine-like in mammalian pharmacology increased the isometric tension of this preparation. These drugs were, in descending order of potency: dimethylphenylpiperazinium, nicotine, acetylcholine, carbachol, decamethonium and pyridine-2-aldoxime methiodide.3. Muscarine-like drugs (oxotremorine, methacholine, pilocarpine) had no activity.4. Potassium and barium ions stimulated the tissue, while the anti-cholinesterases, dichlorvos and eserine, increased the resting tension of the preparation and potentiated the responses to acetylcholine.5. Adrenaline neither stimulated the tissue nor affected the responses to nicotine-like drugs.6. The relative potency of several blocking agents which antagonize the responses to nicotine-like drugs was assayed. These blocking agents were, in descending order of potency: mecamylamine, (+)-tubocurarine, hexamethonium, atropine and piperazine. Acetylcholine, dimethylphenylpiperazinium and pyridine-2-aldoxime methiodide apparently act on a common receptor, for each blocking agent had a similar molar inhibitory concentration against these stimulants.7. It is concluded that the cholinoceptor in muscle preparations of Ascaris lumbricoides is pharmacologically similar to that of the mammalian autonomic ganglion.


Effect of methyl phenyldiazenecarboxylate (azoester) on the feeding behaviour of blood sucking invertebrates.


Effect of monoamineoxidase inhibitors on 5-hydroxytryptamine output from perfused cerebral ventricles of anaesthetized cats. 1. In cats anaesthetized with pentobarbitone sodium, intraperitoneal injections of four inhibitors of monoamine oxidase (MAO) were shown to increase the 5-hydroxytryptamine (5-HT) in the effluent from the perfused cerebral ventricles.2. Weight for weight, tranylcypromine was found to be about twice as potent as pheniprazine, eight times as potent as nialamide and sixty times as potent as pargyline.3. The effect of tranylcypromine was also examined after reserpine had been injected into the cerebral ventricles or after p-chlorophenylalanine, given intraperitoneally. In both conditions tranylcypromine retained its ability to increase the 5-HT output from the perfused cerebral ventricle, but the effect was attenuated, more after p-chlorophenylalanine than after reserpine.4. Evidence is put forward that in both conditions the brain is not completely depleted of its 5-HT, but that the 5-HT is only reduced, more after p-chlorophenylalanine than after reserpine.


Stimulation by glucose of steroidogenesis from acetate by the superovulated rat ovary in vitro.


Respiratory depression in the coma of myxedema: treatment with ethamivan intravenously.


Hormone induced modification of the cell surface.


Significance of mixed oxygenases and nitroreductase in drug metabolism.


Treatment of schistosomiasis japonica with niridazole.


Biochemical basis for the in vitro pro-oxidant action of carbon tetrachloride.


Identification of reduced nicotinamide adenine dinucleotide phosphate-dependent aldehyde reductase in a Rhodotorula strain. Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-aldehyde reductase was isolated in 24% yield and 66-fold purification from a dl-glyceraldehyde-grown Rhodotorula species. This enzyme was specific for NADPH, and d-, l-, or dl-glyceraldehyde were equally good substrates. Other substrates had activities as follows: methylglyoxal, 50%; fructose, 33%; d- and l-arabinose, 12%; d-xylose, 8%; d-glucose, 5%; d-erythrose and d-threose, 0 to 5%. The product from the reduction of dl-glyceraldehyde was glycerol, as shown by high voltage electrophoresis, paper chromatography, and direct enzymatic analysis. Kinetic studies gave K(m) values of 0.89 mm and 0.013 mm for dl-glyceraldehyde and NADPH, respectively. An optimal pH range of 6.3 to 6.7 was found for maximal activity. Reduction of NADP(+) by glycerol was not demonstrable. This Rhodotorula NADPH-aldehyde reductase activity was compared to similar enzymes from other sources.


Nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate-linked succinic semialdehyde dehydrogenases in a Pseudonomas species. A Pseudomonas species grown on polyamines was found to have the following enzymes that can dehydrogenate succinic semialdehyde: a constitutive nicotinamide adenine dinucleotide phosphate (NADP)-linked dehydrogenase, an inducible NAD-linked dehydrogenase specific for succinic semialdehyde (EC 1.2.lb), and more than one inducible NAD-linked aminoaldehyde dehydrogenase which can act on succinic semialdehyde, 3-aminopropanal, and 4-aminobutanal. These enzymes have been separated from each other by ammonium sulfate precipitation, column chromatography on diethylaminoethyl-Sephadex, and electrophoresis on polyacrylamide gel. The level of NAD-linked succinic semialdehyde dehydrogenase in cells grown on various C and N sources has been determined and found to be as expected of an inducible enzyme with, however, two slight variations: the basal level of the enzyme in cells grown on Casamino Acids is relatively high and readily detectable, and the level of this enzyme is the same when the cells are grown on gamma-aminobutyrate with or without glucose and is, therefore, not subject to the classical glucose effect.


Spontaneously occurring bacterial transformations in mice. In 1963, it was reported that deoxyribonucleic acid (DNA)-mediated transformations could take place spontaneously between genetically distinguishable pneumococci growing in a living host, the mouse. It was found in the present study that such transformations could be increased in frequency if infected animals were treated with a drug which kills only one of the two infecting strains. The frequency of in vivo transformations was also increased if the infection was prolonged. Interspecific transformation between pneumococci and streptococci without the addition of purified DNA was demonstrated both in vitro and in vivo. These results make it seem more likely that DNA-mediated transformations occur in nature.


Further studies on the tumour enhancing effect of the local graft-versus-host reaction.


Testosterone metabolism by rat placenta.


Histocompatibility antigens on mouse spermatozoa.


Cholinergic and adrenergic interactions in the thermoregulatory centers of the rat.


Relative "strength" of histocompatibility barriers as compared on the basis of different criteria.


Antigenic strength of non-H-2 systems in mice.


Modulation of mammalian polyol: NADP oxidoreductase activity by ADP and ATP.


Oxidation of 1,5-diphenylcarbazide as a measure of photosystem 2 activity in subchloroplast fragments.


Mechanism of nitrate reduction in Chlorella.


Influence of phenobarbital pretreatment on the in vitro ring A reduction of delta4-3-oxo-steroids in rat liver microsomes.


Effects of Chrysaora quinquecirrha (sea nettle) toxin on the rat cardiovascular system.


The quantitative histochemistry of the experimental glioblastoma: glycolysis and growth.


Gas chromatographic determination of mepivacaine in capillary blood.


The effects of halothane on the responses of cardiac sympathetic ganglia to various stimulants.


Differences in rate of phenotypic expression in separated strands of pneumococcal transforming DNA and evidence for change of reading direction.


Subcellular distribution of tyrosine aminotransferase in rat brain.


Synthesis and some reactions of the pantetheine-glutathione mixed disulfide.


Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems.


Cryptorchism: a brief review of current concepts.


Polyphasic synaptic activity.

Polyphasic synaptic activity.


5-hydroxytryptamine levels in peripheral organs of immunosympathectomized rats.


Studies on immunosuppression by purine nucleoside analogues. II. Effects on skin-graft rejection and immediate hypersensitivity in mice.


Immunosuppressive effects of adamantoyl cytarabine. I. Inhibition of hemagglutinin formation and graft versus host reactions in mice.


Studies on a biphasic lipolytic response to catecholamines in isolated fat cells.


Testosterone inhibition of 6beta-, 7alpha- and 16alphahydroxytestosterone metabolism by rat liver microsomes.


Glyceryl trinitrate and angina.

Glyceryl trinitrate and angina.


Allergic rhinitis and its control by antihistamines: clinical trial of Tavegyl (meclastine).


Epilepsy.

Epilepsy.


Effects of local anesthetics on muscarinic sites of the isolated frog ventricle.


A calorigenic effect of imipramine in the mouse?


Adrenergic changes due to pertussis: insulin, glucose and free fatty acids.


Suppression of renal excretion of fencamfamine in man.


The development and use of the hostility and direction of hostility questionnaire.


Tabular compilation of drug interactions.


Investigation of adrenergic beta-receptor blockade and mescaline-induced bradycardia.


Differentiation of mechanisms of the antilipolytic actions produced by alpha and beta adrenergic blocking agents.


Properties of the bioluminescent protein aequorin.


Characterization of a partially purified photosynthetic reaction center from spinach chloroplasts.


Chiari-Frommel syndrome as a part of the Zollinger-Ellison multiple endocrine adenomatosis complex.


Pharmacology of EEDQ (N-ethoxycarbonyl-2-ethoxy-1-2-dilhydroquinoline).


Frostbite and its sequelae in captive exotic birds.


Effects of various passages on some properties of an attenuated strain of Japanese encephalitis virus with special regard to mosquito infectivity.


Amino acid levels and enzyme activity in tissues of rats force-fed diets differing methionine content.


The young veteran as a psychiatric patient.


Diagnostic lung puncture in the pneumonias of infants and children.


The effect of cholinergic and adrenergic blockage on basal and pentagastrin-induced acid secretion.


Effect of dimethyl sulfoxide on barley and yeast glucose-6-phosphate dehydrogenase.


Biosynthesis of phosphatidylinositol.

Biosynthesis of phosphatidylinositol.


The influence of lactic dehydrogenase on the metabolic pathways of glucose in the ocular tissues of rainbow trout (Salmo gardneri).


Isoenzymes of snail livers. II. Dehydrogenases.


Immunology of spontaneously arising rat mammary adenocarcinomas.


Fight or flight response in clinical practice.


Glucose oxidation in nuclei isolated from frat thymus.


Coronary sinus outflow and O2 content in anterior cardiac vein blood at different levels of right ventricle performance.


Lung disease caused by drugs.

Lung disease caused by drugs.


Influence of sympathetic nerve stimulation on ventricular function in the newborn lamb.


Recovery of noradrenaline in adrenergic axons of rat sciatic nerves after reserpine treatment.


Histochemical studies on the depletion of noradrenaline by adrenaline in adrenergic nerves of the rat iris.


Some effects of dihydroergocrisine and of phentolamine mesylate on renal function in rats.


Conditioning in the prediction of therapeutic outcome in depressions.


The effect of SC-15396, atropine and mepyramine on gastrin-, bethanechol- and histamine-stimulated gastric acid secretion in rats and guinea-pigs.


The actions of atropine, tropenziline and N-butyl hyoscine bromide on the isolated distal colon of the guinea-pig: a comparison of their activities and mechanisms of action.


Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug.


Some observations on the toxicology of morphine-N-oxide.


Gas chromatographic analysis of acetylsalicylic acid, phenacetin, caffeine, and codeine in APC and codeine tablets.


Preservation of fluorescein solutions against contamination with Pseudomonas aeruginosa.


The subcellular distribution of (+)-amphetamine and (plus or minus)-p-chloroamphetamine in the rat brain as influenced by reserpine.


The effects of a phencyclidine derivative, CI-634, on blood pressure in rats.


Treatment of adjuvant arthritis in rats with the histidine decarboxylase inhibitor hypostamine.


Effect of amphetamine and amphetamine-like drugs on homovanillic acid concentration in the brain.


Hypoxia and methionine sulphoximine seizures in mice.


The effects of alpha- and beta-sympathicomimetics on rumen motility and heart rate frequency in conscious goats.


The nature of the products from the reaction between Mayer's reagent and tertiary amines.


Comparative spasmolytic potencies of atropine sulphate and N-butyl hyoscine bromide following intravenous injection, injection into a mesenteric vein, and intraduodenal instillation.


Some effects of resibufogenin: an aglycone of animal origin.


Cobalt ion action on the vascular permeability and mast cells of the rat.


Effects of some anti-inflammatory drugs on capillary permeability of the gastric mucosa in the rat.


Dissolution characteristics of reserpine-polyvinylpyrrolidone co-precipitates.


Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors.


Excitatory adrenergic receptors in the human stomach and pylorus.


The effect of some oral anticholinergics on gastric emptying, pH and osmolarity in man.


The effect of the phenylhydrazine moiety on the substitution at the carbonyl residue in phenylhydrazones of isohydrocoriamyrtin and allethrolone.


Coriamyrtin. 13. The reactions of isohydrocoriamyrtin and isocoriamyrtin with phenylhydrazine analogues.


Electrophysiological and pharmacological properties of the stomach of the squid Loligo pealii (Lesueur).


Modified lipophilic vitamin. II. Effect of tocopheronolactone on lipid-peroxidation.


Steroid biosynthesis by the equine testis.


MMPI correlates of religiousness in late adolescent college students.


Retrospective study of 200 maldescended testicles and results of follow-up.


Participation of antibodies in acute cardiac-allograft rejection in man.


Antibodies and rejection.

Antibodies and rejection.


In vitro characterization of adrenergic receptors controlling skin gland secretion in two anurans Rana pipiens and Xenopus laevis.


Microelectrode studies on the membrane properties of isolated mitochondria. II. Absence of a metabolic dependence. Mitochondrial membrane potentials and resistances have been determined under various metabolic conditions by the use of piezoelectric-driven microelectrodes. The mean state 3 potentials (about +19 mv) are higher than the potentials in state 4 (about +9 mv). DNP in uncoupling concentrations or KCN have no significant effect on membrane resistance or potential. Previous experiments have shown the potential to be sensitive to mitochondrial swelling and have suggested that it depends predominantly on anionic distribution.


Treatment of encephalitis in children with centrophenoxin as a supplementary drug.


Control of specific gene expression examined in synchronized mammalian cells. The control of synthesis of the steroid-inducible enzyme, tyrosine aminotransferase (TAT), has been studied in synchronized cultures of HTC cells, an established line of rat hepatoma cells. During the mitotic and early G1 periods of the generation cycle of cells previously exposed to inducer, TAT synthesis is maximal in the absence of inducer, i.e., synthesis is constitutive. (By contrast, in random cells maximal TAT synthesis is always dependent upon the presence of the inducer.) After the third hour of G1 "G1[3]"), TAT synthesis is inhibited by a specific posttranscriptional repressor, the formation of which requires RNA synthesis. We speculate that this repressor is antagonized by the steroid inducer. The degradation of TAT during mitosis and G1 is constant and not affected by cycloheximide or actinomycin D in our experiments.


Differential radioprotection by glutathione of two growth functions in the hydroid Campanularia flexuosa.


The effects of carbon tetrachloride and some antioxidants on the hydroxylation of tetralin by rat liver homogenate.


Peritoneal and alveolar macrophages derived from lymphocyte populations during graft-versus-host reaction.


Mixed function oxidation in perfused rat liver. The effect of aminopyrine on oxygen uptake.


Enzyme histochemistry and hormones of the developing gastrointestinal tract of the chick embryo. II. The histochemistry of oxidative enzymes.


Characterization of phospholipase B of Culex pipiens fatigans. Phospholipase B has been found in the mosquito Culex pipiens fatigans, and some of its properties have been studied. The enzyme had a high optimum temperature (45 degrees C) and broad alkaline pH optimum (8-9). It was inactive toward diacylphospholipids, and hydrolyzed lysolecithin at a higher rate than lysophosphatidyl ethanolamine. The enzyme was heat labile, but lysolecithin protected it against heat inactivation. Phosphatidyl ethanolamine, phosphatidyl choline, deoxycholate, Fe(+++), and Hg(++) inhibited the enzyme markedly. The enzyme was present mainly in larvae; little enzyme activity was detected in pupae or adults. The total and specific activities were highest in IV instar (6 day) and I instar (1st day) larvae, respectively. It was localized in the microsomal fraction and was distributed mainly in the abdomen and thorax of the insect. The enzyme was present at much higher levels of activity in larvae of the mosquitoes Anopheles stephensi and Aedes aegypti.


Ileus: use of sympathetic blocking agents in its treatment.


Selective cardiac sympathetic blockade as an adjunct to bronchodilator therapy.


The nature of the adrenergic receptors in isolated human bronchi.


Hypertensive pulmonary arteritis.

Hypertensive pulmonary arteritis.


Alpha excitatory, alpha inhibitory and beta inhibitory adrenergic receptors in the guinea-pig stomach.


Comparison of the effects of pronethalol, MJ 1999, D(-) INPEA and L(+) INPEA on the pressor response to acethycholine in atropinized dogs.


The effect of the opticalisomer of N-1-(4'-nitrophenyl)-2-isopropylethanolamine (INPEA) on the uptake of 3H-norepinephrine by the cardiac muscle of the rat in vitro.


Effects of a new beta-adrenergic receptor blocking agent, alprenolol, andts optical isomers.


Effect of some beta-pyridyl derivatives and of histamine on the rat uterus under different functional states.


The effects of pronethalol and propranolol on the coronary circulation of the dog. 1. The actions of pronethalol and propranolol have been studied to see if there was any relationship between the reduction in coronary flow and any other cardiovascular action they have.2. The experiments were carried out in anaesthetized open chest dogs. Measurements included central arterial, left and right venous or atrial pressures, heart rate, ventricular size and stroke volume, intra-ventricular pressures, total left coronary flow, arterial and coronary sinus blood pO(2). The pressure-time index (PTI) and maximum rate of isovolumetric contraction (dp/dt) were obtained from these records.3. It was concluded that, in these experiments, the reduction in coronary flow produced by pronethalol and propranolol was not directly related to a decrease in perfusion pressure, a raised venous pressure, the increase in ventricular volume and hence wall tension, the decrease in heart rate, or to the increased duration of systole.4. The PTI and dp/dt were always reduced at the same time as the coronary flow. These findings are discussed.5. Studies of the effects of sympathetic stimulation, of phentolamine, of reduced arterial oxygen tension and electrical pacing of the heart, all after beta-blockade, did not support the suggestion that the reduction in coronary flow after beta-blockade was due to the unmasking of an active vasoconstriction.


Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. 1. The effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) on myocardial and general haemodynamics were studied in anaesthetized cats.2. Alprenolol (0.5 mg/kg and 1.0 mg/kg) reduced femoral systolic and diastolic pressures, heart rate and left ventricular systolic pressure. The rate of rise of the left ventricular pressure pulse (dp/dt) was reduced despite a significant elevation of left ventricular end-diastolic pressure. This is evidence for decreased myocardial contractility. On some occasions there was a transient initial increase in +ve dp/dt max. possibly indicative of moderate beta-adrenoceptor stimulant activity.3. Myocardial and liver blood flows were measured using a heated thermocouple technique. Alprenolol slightly decreased both myocardial and liver blood flows (mean of 17% and 15% respectively with a dose of 1.0 mg/kg). Myocardial and liver vascular resistances were only very slightly increased.4. Alprenolol had no direct effect on calculated myocardial and liver metabolic heat production.5. In doses up to 1.0 mg/kg alprenolol had no effect on airway resistance but occasionally decreased (in vivo) intestinal muscle movement.6. Since alprenolol (although reducing calculated myocardial oxygen consumption and the myocardial and metabolic heat stimulant effects of catecholamines) has no significant effect on myocardial vascular resistance, it is suggested that it would be a useful adjunct in the therapy of angina pectoris.


Interaction between (plus or minus)-amphetamine and atropine on the rat cardiovascular system. 1. The effects of atropine on the pithed rat blood pressure after (+/-)-amphetamine depend on the pattern of the cardiovascular responses to the latter.2. If the pressor response to amphetamine is followed by oscillations of blood pressure and a reduction in pulse pressure or by a fall in blood pressure terminating in circulatory failure, atropine increases blood pressure, but if it is not followed by these patterns, atropine decreases blood pressure.3. The fall in blood pressure produced by atropine after amphetamine might be due to weak alpha-adrenoceptor blockade.


The effect of marked hyperventilation upon tissue levels of NADH, lactate, pyruvate, phosphocreatine, and adenosine phosphates of rat brain.


A comparison of the anti-arrhythmic actions of I.C.I. 50172 and (--)-propranolol and their effects on intracellular cardiac action potentials and other features of cardiac function. 1. I.C.I. 50172 had marked quinidine-like effects on intracellular cardiac action potentials at concentrations above 20 mg/l. (6.61 x 10(-5)M). The rate of rise and overshoot of the action potential, conduction velocity and contractions were decreased. (-)-Propranolol had similar effects at less than 1/30 this concentration.2. I.C.I. 50172 had 1/100 the activity of (-)-propranolol as a local anaesthetic. Since this is also the ratio of their in vitro beta-receptor blocking activities, I.C.I. 50172 provides no net increase in specificity of beta-receptor blockade.3. In contrast, the in vivo activity of I.C.I. 50172 in protecting anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation was 40% that of (-)-propranolol.4. Structure-activity relations of beta-receptor blocking drugs are discussed.