Isolation of viruses from swallowticks, Argas cooleyi, in the southwestern United States.


Effect of nembutal on uninfected and encephalomyocarditis virus-infected Krebs-II carcinoma cells.


Subviral infectivity in nuclear polyhedrosis of the great wax moth (Galleria mellonella L.).


Morphological changes in cell cultures infected with plague mutants of Chikungunya virus.


Structure of Australia antigen.

Structure of Australia antigen.


Use of DEAE-cellulose in testing disinfectants.


Effect of a thenoyl amide derivative on polysome profiles in influenza A2 virus-infected cells.


Interferon formation induced by various viruses in cultures of leukocytes from children vaccinated against measles.


Deoxyribonucleic acid base composition of members of the typhus group of rickettsiae.


Purification and properties of a microsomal cyclic adenosine monophosphate binding protein required for the release of tyrosine aminotransferase from polysomes.


Physician's assistants in Georgia.

Physician's assistants in Georgia.


Inotropic and toxic responses to acetylstrophanthidin in young animals: relationship of hypercapnia and beta adrenergic blockade.


Aniline hydroxylase microassay suitable for needle biopsy specimens: effects of phosphate and pyrophosphate on aniline hydroxylation.


A comparative study of the hepatic and pulmonary microsomal mixed-function oxidase systems in the rabbit.


On the pharmacology of autonomic ganglia.


Degradation of messenger RNA in mammalian cells.


Fifth Australian Orthodontic Congress opening address.


Interaction of oxygen and aromatic amines with hepatic microsomal mixed-function oxidase.


Filariasis.

Filariasis.


Biosynthesis of phosphatidic acid in mitochondria and microsomes via the acylation of sn-glycero-3-phosphate.


An effective treatment for injuries to the young, permanent anterior teeth.


A technique for accurate soldering.

A technique for accurate soldering.


Host-feeding patterns of Florida mosquitoes. II. Culiseta.


Direct and reflex effects of nitroglycerin on coronary and left ventricular dynamics in conscious dogs. The effects of intravenous and sublingual glyceryl trinitrate (nitroglycerin), 40 mug/kg, were studied on coronary blood flow and resistance, left ventricular (LV) pressures (P) and diameters (D), rate of change of pressure (dP/dt), (dP/dt)/P, and on the velocity (V) of myocardial fiber shortening in conscious dogs. Nitroglycerin i.v. caused substantial coronary vasodilatation prior to any changes in systemic hemodynamics. Mean coronary flow increased by a maximum of 47 ml/min and coronary sinus P(o2) rose from 16 to 26 mm Hg while pressure and diameter began to fall, and heart rate began to rise. After the maximal fall in mean arterial pressure (-26 mm Hg), a secondary peak in coronary flow occurred which was associated with increases in heart rate (100 beats/min), (dP/dt)/P (22%), and isolength V (12%). Beta blockade prevented the reflex increases in contractility but only a part of the reflex tachycardia; the remainder was prevented by cholinergic blockade. Maintaining heart rate constant minimized the decreases in LV D and increases in contractility. When the reflex inotropic and chronotropic effects were prevented by a combination of atrial pacing and beta blockade the early coronary vasodilatation was unaltered, but the later coronary vasodilatation was minimized. Thus i.v. nitroglycerin in the conscious dog exerts a potent direct coronary vasodilating action and also a secondary coronary vasodilation caused by reflex increases in contractility and heart rate. The decreases in diameter are largely the result of tachycardia. Sublingual nitroglycerin produced directionally similar, but quantitatively lesser effects on coronary flow and resistance, LV D, LV P, and contractility.


Spontaneous behaviour in neural networks.


Pneumococcal transformation.

Pneumococcal transformation.


Group psychotherapy with addicted smokers.


Angiographic assessment of autogenous vein grafts.


Adenosine 3':5'-cyclic monophosphate control of the enzymes of glutamine metabolism in Escherichia coli. The effect of cAMP on the intracellular levels of five enzymes concerned with the interconversion of glutamate and glutamine in E. coli has been examined. Cyclic AMP added to the culture medium increases the levels of glutamate dehydrogenase (EC 1.4.1.4) and glutamine synthetase (EC 6.3.1.2); it decreases the levels of glutamate synthase (EC 1.4.1.X), and glutaminase A (EC 3.5.1.2). Cyclic AMP did not affect the level of glutaminase B (EC 3.5.1.2). These alterations in enzyme levels by cAMP require cyclic AMP receptor protein, since the levels of these enzymes were unchanged by cAMP in a mutant lacking this receptor. Chloramphenicol also abolished the effects of cAMP, a result that implies protein synthesis is necessary for these changes in enzyme levels to occur. The reciprocal effects of cAMP on the levels of these enzymes may play an important role in the cellular regulation of nitrogen metabolism.


Mechanism of hormonal induction of tyrosine aminotransferase studied by measurement of the concentration of growing enzyme molecules. Proteins labeled in cultured hepatoma cells grown in the presence of radioactive amino acids and pactamycin consist primarily of growing polypeptide chains initiated before addition of the antibiotic. Nascent tyrosine aminotransferase (EC 2.6.1.5) molecules were labeled in this way, and their radioactivity after completion was measured immunologically. Cells exposed to the synthetic adrenal steroid, dexamethasone, contain 10- to 18- times as much nascent enzyme as uninduced cells. These results indicate that induction control is not at the level of polypeptide-chain elongation or release, but probably operates on either the amount of messenger RNA or the rate of specific polypeptide-chain initiation.


In vivo activity of cytotoxic lymphocytes.


Impact of fractionation procedures on lymphocyte activities in vitro and in vivo. Separation of cells with high concentrations of surface immunoglobin.


Tolerance and enhancement in organ transplantation.


Lymphocyte environment and the durability of transplantation tolerance.


Bilateral phaeochromocytoma in two brothers.


Studies on the feedback actions of gonadal steroids on gonadotropin and prolactin secretion: effects, sites and mechanism of action.


Bronchodilator and corticosteroid effects on regional and total airway resistance in patients with asthma, chronic bronchitis, and chronic pulmonary emphysema.


Photokinetic assay of NADH and NADPH in microdissected tissue samples.


Liver microsomal metabolism of aflatoxin B 1  to a reactive derivative toxic to Salmonella typhimurium TA 1530.


Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.


Naturally occurring and induced levels of amino acid transport and tyrosine aminotransferase in rats bearing Morris hepatomas.


Control of the adenosine 3',5'-monophosphate-adenyl cyclase system in the livers of developing rats.


The role of dental materials in the prevention of dental diseases.


Seven scales for the Minnesota-Briggs History Record with reference group data.


Psychopathological correlates of anthropometric types in male schizophrenics.


A new empirical automated MMPI interpretive program: the 6-8--8-6 code type.


A new empirical automated MMPI interpretive program: the 2-4--4-2 code type.


Moderating effects of age and sex on the association of medical diagnoses and 1-3--3-1 MMPI profiles.


Psychiatric patient self-description via self-report and the MMPI.


The Mayo Clinic Automated MMPI program: cross validation with psychiatric patients in an army hospital.


MMPI alcoholism scales.

MMPI alcoholism scales.


MMPI, Internal-External Control, and Problem Check List scores of obese adolescent females.


Inner- versus other-directedness and hypomanic tendencies in a nonpsychiatric population.


Validity of the Mini-Mult with male reformatory inmates.


Parkinsonian patients' scores on Hovey's MMPI scale for CNS disorder.


Disruptive selection.

Disruptive selection.


Recognizing and managing drug eruptions.


The uptake of glucose by a thermophilic Bacillus sp.


Role of phosphoenolpyruvate-phosphotransferase in glucose utilization by bacilli.


The role of lymphocytes in antibody formation. 3. The origin from small lymphocytes of cells forming direct and indirect haemolytic plaques to sheep erythrocytes in the rat.


The molars of tabby chimaeras in the mouse.


The role of lymphocytes in antibody formation. IV. Carriage of immunological memory by lymphocyte fractions separated by velocity sedimentation and on glass bead columns.


A simple network capable of inductive generalization.


Biosynthesis of furocoumarins: further studies on Ruta graveolens.


Effect of thio- and hydrazino-derivatives of uracil, 6-azauracil and 6-azathymine on the growth of some microorganisms in vitro.


Thionicotinamide-NADP, a nucleotide analog interfering with ferredoxin-NADP reductase-ferredoxin interaction.


Increase in adenosine triphosphatase activity of Ehrlich ascites tumor cells following serial cultivation in media with increased (hypertonic) NaCl content.


Increased oxygen consumption of Ehrlich ascites tumor cells following serial cultivation in media with increased (Hypertonic) NaCl content.


Hypergonadotrophic hypogonadism with anosmia.


Enzymic oxidation of some resistant D-amino acids.


Use of chloroform to terminate the enzyme reaction in the assay of inorganic pyrophosphate-glucose phosphotransferase in rat liver.


Automated fluorometric analysis of biological compounds.


Light-driven periodic changes in urocanase activity of a heterotrophic bacterium.


Preliminary report of a new  -adrenergic blocking agent in Thai patients with cardiac hyperactivity.


Adverse hematologic effects of drugs.

Adverse hematologic effects of drugs.


Purinergic nerves.

Purinergic nerves.


The Mf scale as an index of disturbed marital interactions: a replication.


Relationships between admission variables and MMPI scale scores of hospitalized alcoholics.


The psychiatric side-effects of drugs.

The psychiatric side-effects of drugs.


Initial management of severe open injuries and traumatic amputations of the foot.


Mouthguards in Australian sport.

Mouthguards in Australian sport.


Hormonal effect on tyrosine aminotransferase activities in Yoshida sarcoma and its variant lines.


Tetrahydrobiopterin, a cofactor in mitochondrial electron transfer. A soluble transfer system.


Potentiation of antitumor activity of cyclophosphamide by centrophenoxine.


Altered levels of glucose-6-phosphate dehydrogenase stabilizing factors in X-linked chronic granulomatous disease.


The ambulatory slipper cast.

The ambulatory slipper cast.


Clarification of the cardiomyopathies.

Clarification of the cardiomyopathies.


Fibrinolytic activity of renal transplants in rabbits relation to graft thrombosis and necrosis.


Fatal meningitis in a case of otosclerosis operated upon bilaterally.


Sequential estimation of plasma catecholamines in exercise-induced asthma.


Pseudoephedrine and the dog's eustachian tube.


An electron microscopic study of the rat testis in experimental cryptorchidism.


Treatment of arrhythmias with tolamidol.


Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. VI. Structural changes in mitochondria associated with inactivation of electron transport activity.


Karyometrical and histochemical studies of adult male rat adrenal cortex after treatment with aminoglutethimide.


Pyridine nucleotide transhydrogenase from Azotobacter vinelandii. Some aspects of its structure.


Properties of a specific protease for pyridoxal enzymes and its biological role.


Chippewa and majority alcoholism in the Twin Cities: a comparison.


Hypnotic drugs.

Hypnotic drugs.


Socio-odontologic investigation of school children with high and low caries frequency.


Stimulation of erythropoiesis by pyridine nucleotides.


Haematuria parasitaria and urinary calculi: early indications from Africa.


Sparganosis in the Masailand.

Sparganosis in the Masailand.


Comparisons between three small collections of Glossina morsitans morsitans (Machado) (Diptera: Glossinidae) from the Kilombero River Valley, Tanzania. 1. Characteristics of flies exhibiting different patterns of behaviour.


Sterility from crosses between sub-species of the tsetse fly Glossina morsitans.


Ultrastructural study of the midgut mycetome-bacteroids of the tsetse flies Glossina morsitans, G. Fuscipes, and G, brevipalpis (Diptera, Brachycera).


The effect of glucagon on the development of glycogen phosphorylase and glycogen synthetase in rat liver.


Biochemical and cytogenetic characterization of rat hepatoma cell lines in vitro.


An in vitro study of monosaccharide absorption in echinoid gut.


An in vitro study of amino acid and sugar absorption in the gut of Echinus esculentus.


Purine and pyrimidine absorption by the gut of the chiton, Cryptochiton stelleri.


Uptake and assimilation of amino acids by Biomphalaria glabrata (Gastropoda: Planorbidae).


Cardiovascular responses to spinal cord stimulation and autonomically active drugs in Squalus acanthias.


The contractile blood vessels of the earthworm, Lumbricus terrestris.


A study of hibernator erythropoietic responses to simulated high altitude.


Cation transport and energy metabolism in the nucleated erythrocyte of the dogfish shark, Squalus acanthias.


Evidence for a circannual metabolic cycle in Citellus tridecemlineatus, a hibernator.


Intestinal amino acid transfer in the pig (Sus scrofa).


Ionic and body compartment responses to increasing salinity in the perch Perca fluviatilis.


Ionic patterns in the teleost.

Ionic patterns in the teleost.


Urine composition of some hystricomorph rodents confined to metabolism cages.


Seasonal variation in heart rate response to core temperature changes.


Studies on the control of electrolyte excretion by the nasal gland of the lizard Dipsosaurus dorsalis.


The effect of cold acclimation upon glucose-6-phosphatase activity in two species of free-living nematodes. I. The effect of pH.


Amino acid receptors in the antennules of Homarus americanus.


The effect of changes in ambient temperature on spontaneous activity in skipjack tuna.


Induction of T cell tolerance in agammaglobulinemic chickens.


The use of prindolol (Visken) in the treatment of hypertension.


Histocompatibility studies in a closely bred colony of dogs. 17 Cooperstown beagles of known DL-A genotypes were exposed to supralethal total body irradiation and received a bone marrow allograft from a DL-A-identical donor; 11 littermate and 6 nonlittermate donor-recipient pairs were studied. The recipients are surviving uneventfully for 315, 364, 424, 440, 531, 531, 584, 605, 625, 635, and 649 days in the littermate group and for 211, 279, 280, 368, 479, and 480 days in the nonlittermate group. The radiation chimeras underwent bilateral nephrectomy and received a kidney allograft obtained from their respective marrow donor within 43-120 days after bone marrow transplantation. The renal allografts are surviving for 191, 200, 221, 234, 313, 349, 361, 377, 378, 405, 441, 444, 482, 557, 580, 581, and 586 days, respectively. 12 of 13 skin allografts obtained from the marrow donor are at present surviving in the recipients for 107, 110, 110, 110, 116, 122, 128, 143, 143, 162, 178, and 199 days, respectively; one graft was rejected at 84 days. In contrast, the radiation chimeras rejected 25 skin allografts obtained from DL-A-incompatible donors within 10.5-21 days (MST = 15.2 days). Skin transplants obtained from DL-A-identical siblings of the bone marrow donors were rejected within 20-36 days (MST = 25.8 days) in recipients of bone marrow cells obtained from littermate donors. Recipients of nonlittermate bone marrow transplants accorded such allografts a prolonged survival time of 27-76 days (MST = 56.2 days). Prospective selection of genotypically DL-A-identical donor-recipient pairs results in the regularly reproducible long-term survival of bone marrow allografts. The radiation chimeras produced in this manner have developed a donor-specific state of unresponsiveness to kidney and skin allografts. The results are consistent with the existence in the canine species of at least three closely linked genetic systems relevant to transplantation, including DL-A, MLC, and a possible bone marrow transplantation locus.


Genetic control of the immune response. The effect of graft-versus-host reaction on the antibody response to poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys in nonresponder mice. The transfer of parental (H-2(k/k)) nonresponder lymphoid cells into heterozygous (H-2(k/q)) nonresponder recipients at the time of primary challenge with aqueous poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys [(T,G)-A--L] elicited the production of both IgM and IgG anti-(T,G)-A--L antibody. Normally, the production of IgG anti-(T,G)-A--L antibody is restricted to strains possessing the responder Ir-1 allele. The timing and intensity of the graft-versus-host (GVH) reaction required for this effect were found to be critical. Injection of H-2(k/k) cells into H-2(k/q) recipients 1 wk before antigen challenge did not elicit IgG anti-(T,G)-A--L antibody production, and markedly suppressed IgM anti-(T,G)-A--L antibody production. The transfer of alloimmune (H-2(q)-primed) H-2(k/k) cells at the time of antigen challenge was also associated with no IgG and little IgM anti-(T,G)-A--L antibody production. These data are consistent with the model that nonresponder thymus-derived lymphocytes (T cells) activated in a GVH reaction can substitute for (T,G)-A--L-reactive T cells to induce a shift from IgM to IgG anti-(T,G)-A--L antibody production.


Efficacy of thiopropazate dihydrochloride (Dartalan) in treating persisting phenothiazine-induced choreo-athetosis and akathisia.


Inhibition of the graft-versus-host reaction. I. Reduction of the graft-versus-host potential of mouse spleen cells (with a sparing of stem cells) by treatment with antilymphocyte globulin-derived Fab fragments.


The mechanism of specific immunosuppression of renal allograft rejection by donor strain blood.


An enzymic fluorometric micro method for determination of glycoen.


Red cell enzyme deficiencies: a review.

Red cell enzyme deficiencies: a review.


Thin-layer chromatographic determination of the optical purity of labeled amino acids via dipeptide formation.


A comparison of the in-vivo CO 2  titration curves of arterial and mixed-venous blood in dogs.


Natural infection of swine by Japanese encephalitis virus and its modification by vaccination.


The incidence, prevention and treatment of dysrhythmias during anaesthesia for oral surgery.


Aflatoxin metabolism in duck-liver homogenates: the relative importance of reversible cyclopentenone reduction and hemiacetal formation.


The DNA-membrane fraction of Pneumococcus contains a DNA replication complex.


National certification of physicians' assistants by uniform examinations.


Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat. 1. The effect of electrical stimulation of the distal cut ends of the renal nerves of unilaterally nephrectomized, anaesthetized cats was studied. Using stimulation parameters of 15 pulses per second (pps), 15 V and 0.2 msec duration, there was an immediate sharp drop in renal blood flow, as determined by an electromagnetic flowmeter, which was maintained for about 2 min. Flow gradually returned to control values over approximately the next 10 min in spite of continued stimulation for up to 30 min.2. Plasma renin activity (PRA) increased markedly after 10 min of stimulation but 20 min later fell towards pre-stimulation values whether stimulation was maintained or not.3. Phentolamine, an alpha-adrenergic-receptor antagonist, abolished both the blood flow and PRA responses to a 10 min period of renal nerve stimulation.4. When the renal artery was constricted in order to produce blood flow changes similar to those found with renal nerve stimulation, the rise in PRA was similar to that observed with renal stimulation.5. In phentolamine-blocked animals, renal artery constriction, as described, produced the same effect on PRA as was observed with renal nerve stimulation.6. Propranolol, a beta-adrenergic-receptor antagonist, did not block the blood flow response to renal nerve stimulation, but did block the rise in PRA normally associated with renal nerve stimulation.7. It is suggested that the effect of renal nerve stimulation on PRA is mediated, primarily, by changes in renal blood flow and that one of the steps leading to renin release following stimulation is sensitive to propranolol. This step must be distal to the effect on vascular smooth muscle.


Metabolic effects of ethanol.

Metabolic effects of ethanol.


An ultrastructural study of the spermatozoon of Eudendrium ramosum.


Sialographic abnormalities in Sjogren's syndrome, rheumatoid arthritis, and other arthritides and connective tissue diseases. A clinical and radiological investigation using hydrostatic sialography.


The renin-angiotensin system through the phylogenetic scale.


The outpatient treatment of heroin addicts with methadone.


Effects of constant environmental temperatures of 10 degrees C and 31 degrees C on serum biochemical and hematologic measurements of heat-tolerant and cold-tolerant cattle.


Effect of temperature and ration on blood clotting time of heat-tolerant and cold-tolerant cattle.


Plasma kininogen content of toads, fowl and reptiles.


The giant neurons of Tritonia: its electric properties and the ionic dependence of the action potential.


Red cell 2,3-diphosphoglycerate in heat-acclimated hamsters.


Induction of tissue swelling by alteration of orientation of tissue sacs.


Urine concentrating ability of arousing and normothermic ground squirrels (Spermophilus columbianus).


The effect of a graded dose of antigen on the production of hyperimmune anti-mesogastropod ascitic fluid.


CNS control of body temperature during hibernation.


In vitro calcium transport in laying fowl intestine: effect of bile preparations.


Responses of gustatory cells in the tongue of rat to stimuli representing four taste qualities.


Calorigenic effect of adrenaline and noradrenaline in the frog, Rana temporaria.


Oxygen consumption in burrowed and unburrowed ammocoetes of Lampetra planeri (Bloch).


A study of the effect of folic acid deficiency on the amino acid composition of the gonadal hormone-stimulated oviduct of the immature female fowl.


Seasonal variation in blood viscosity of the black bear (Ursus americanus).


Fibrinogen concentration in reindeer blood.


Urea biosynthesis in the South American lungfish, Lepidosiren paradoxa: relation to its ecology.


Investigations of the structure of glutamine synthetase from pig brain.


Epicillin: experimental chemotherapy, pharmacodynamics, and susceptibility testing. Epicillin exhibits excellent therapeutic activity when administered orally or subcutaneously to mice infected with a variety of pathogenic bacteria. These included single strains of Streptococcus pyogenes, non-penicillinase-producing Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Salmonella schottmuelleri, and Pseudomonas aeruginosa, strains of microorganisms selected as typical of those that frequently cause serious clinical infections. In oral chemotherapeutic comparisons of tetracycline, chloramphenicol, cephalexin, ampicillin, and epicillin, the latter, with but minor exceptions, exhibited activity comparable to that of most of the other antibiotics studied. Oral administration to mice of a loading dose of epicillin or ampicillin resulted in similar peak blood levels and decay curves. The concentration in urine and the excretion rates were significantly higher in epicillin than in ampicillin-treated animals. Presumptive evidence suggests that the inter-pretation of zone diameters obtained with 10-mug epicillin discs should be the same as is used for 10-mug ampicillin discs.


Purification of pneumolysin.

Purification of pneumolysin. A procedure for the purification of pneumolysin has been developed. Its use results in a 96-fold increase in specific activity from the original crude pneumococcal extract to the final purified product. The purified material is heat-labile and is inactivated by trypsin and cholesterol; inactivation by p-hydroxymercuribenzoate can be reversed by mercaptoethanol. Intravenous administration of the material to rabbits results in crenation, increased osmotic fragility, and intravascular lysis of the erythrocytes of the animal.


Enzyme activities of the livers of mice infected with Salmonella typhimurium. The activities of the mouse liver enzymes tryptophan oxygenase, tyrosine aminotransferase, and pyruvate kinase were measured after infection with three dose levels of Salmonella typhimurium strain SR-11. Infection occurred in all groups as evidenced by an increase in bacterial numbers and by death of the animals. The activities of the enzymes increased in all groups during the course of the infection. The results obtained during infection are compared with those obtained after endotoxin injection.


Tissue amino acid flux after exposure of rats to Diplococcus pneumoniae. The concentration of 21 individual free amino acids in serum, liver, and skeletal muscle was determined in rats during the incubation, acute illness, and terminal stages of experimental infection with Diplococcus pneumoniae. By 4 hr after subcutaneous inoculation with bacteria, the concentration of total and many individual free amino acids in serum, liver, and muscle was significantly decreased in comparison to findings in noninfected, pair-fed control rats. By use of a nonmetabolizable amino acid analogue (cycloleucine), it was possible to detect a flux of amino acids from muscle to liver in the infected rat. The endogenous amino acids which moved to the liver were rapidly utilized for the synthesis of serum proteins.


Developmental aspects of hepatic and extrahepatic drug-metabolizing enzyme systems: microsomal enzymes and components in rabbit liver and lung during the first month of life.


Advance in histamine antagonists.

Advance in histamine antagonists.


Complications of jogging.

Complications of jogging.


Australia antigen in Papua New Guinea.

Australia antigen in Papua New Guinea.


Inhibition by deuterated water of the mixed-function oxidases of hepatic microsomes of the male rat.


Production of antibodies to rat liver phenylalanine hydroxylase. Cross-reactivity with other pterin-dependent hydroxylases.


Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.


Regulation of adrenal phenylethanolamine N-methyltransferase activity in three inbred mouse strains.


Immunological enhancement: a study of blocking antibodies.


Recent research on spinal cord injury.

Recent research on spinal cord injury.


Release of neurotransmitters and their interaction with receptors.


New N-isopropyl and N-tert.-butyl-phenoxypropanolaminic derivatives having  -adrenolytic, anti-arrhythmic and local anaesthetic activity.


The use of amphetamine induced stereotyped behaviour as a model for the experimental evaluation of antiparkinson agents.


The psychological adjustment of rheumatic fever patients with and without chorea. Comparisons ten years later.


Increase in number of splenic transplantable colony-forming units in the SJL-J mice after infection with Rauscher leukemia virus.


Altered host-allograft relationships for mouse tumors modified by prior passage in vitro and in vivo. II. Reactivity of lymphoid cells.


Recent studies on the binding of cortisol in serum.


Allergy to insect stings.

Allergy to insect stings.


Do we really need more pediatricians?

Do we really need more pediatricians?


Image intensification applied to biological problems.


The use of radioisotopes in normal and diseased joints.


An attempt to use the MMPI as a predictor of failure in military training.


Age determination of some flies and mosquitos by daily growth layers of skeletal apodemes. A new method of determining age in certain Diptera, including Culex and Aedes mosquitos, involves counting-sometimes with the aid of staining techniques-the layers of cuticle growth that form daily at different points (inner apodemes) of the skeleton. If developed, the method would be of great importance for eradication and control programmes. The authors recommend further studies, in particular on the application of the technique to Anopheles and certain flies such as Calliphora.


Sulfhydril groups and the concerted inhibition of NADP +  -linked isocitrate dehydrogenase.


Acclimation to simulated altitude in the lizard Dipsosaurus dorsalis.


Further studies on the specificity of the anti-A agglutinin from Helix pomatia.


Localization of 4- 14 C cortisol in the gills of the North American eel (Anguilla rostrata Lesueur).


Amide and thio-amide permeability across the urinary bladder of Rana esculenta. Effect of posthypophyseal hormones.


Intestinal salt and water transport in a euryhaline teleost, Aphanius dispar (Cyprinodontidae).


The renal reabsorption of histidine, leucine and the cationic amino acids in the young cockerel (Gallus domesticus).


Phosphate absorption and alkaline phosphatase activity in the small intestine of the adult mouse and of the chick embryo and hatched chick.


Electrical activity of the olfactory structures in connection with the thermal environment in a tropical frog, Rana occipitalis.


Telost caudal neurosecretory system: effects of osmotic stress on urophysial proteins and active factors.


The vestibular system of the owl.

The vestibular system of the owl.


Pulmonary, branchial and cutaneous gas exchange in the mud puppy, Necturus maculosus maculosus (Rfinesque).


Crop volume, nectar concentration and hummingbird energetics.


Calcium and phosphorus in the skeleton and blood of the lungfish Lepidosiren paradoxa, with comment on humoral factors in calcium homeostasis in the Osteichthyes.


Seasonal variations in serum concentration and half-life of hedgehog IgG2.


The influence of environmental temperature on the metabolism and liver composition of the immature male chick.


A distinct component of proline transport in chicken small intestine.


Intestinal absorption in experimental Salmonella enterocolitis in mice.


Electrical potential difference across the cloaca and colon of the Australian lizards Amphibolurus ornatus and A. intermis.


The effect of sodium, calcium and magnesium on the overshoot amplitude of the action potential from giant neurons of Planorbarius corneus.


Intracellular calcium injection causes increased potassium conductance in Aplysia nerve cells.


Erythropoietic activity in Rana pipiens--the influence of nutrition and season on spleen and peripheral blood activities.


Mitotic activity in dorsal epidermis of Rana pipiens.


Annual lipid cycle of the gray bat, Myotis grisescens.


Permeability of the blood-brain barrier system to rubidium in euthermia, hibernation and hypothermia.


The effects of short and prolonged cold exposure on arousal in the free-tailed bat, Tadarida brasiliensis cynocephala (Le conte).


Hemoglobin concentration in a new air-breathing fish.


Separation of T and B lymphocytes by preparative cell electrophoresis.


Comparative effects of some cardioactive agents on automaticity of cultured heart cells.


Electrochemically driven biochemical reactions. I. Reduction of pyridine nucleotides in aqueous solution.


Professional liability in exercise testing for cardiac performance.


Synthesis of ribonucleic acid by isolated rat liver mitochondria. Rat liver mitochondria isolated in sucrose-N-tris(hydroxymethyl)methyl-2-aminoethane-sulphonic acid (TES) incorporated [(3)H]UTP into RNA for 1h. Incorporation was inhibited 50% by 1mug of actinomycin D/ml, 1mug of acriflavine/ml and 0.5mug of ethidium bromide/ml but was insensitive to rifampicin, rifamycin SV, streptovarcin and deoxyribonuclease. After the first 10min of incubation, the synthesis was insensitive to ribonuclease. RNA synthesis by mitochondria isolated in sucrose-EDTA was insensitive to actinomycin D and sensitive to ribonuclease during the first 10min of the incubation but thereafter the sensitivities were the same as for mitochondria isolated in sucrose-TES. In a hypo-osmotic medium the relative extent of incorporation of the four ribonucleoside triphosphates into RNA was CTP>UTP=ATP>>GTP. In an iso-osmotic medium the incorporation of CTP and GTP decreased. All four nucleotides were incorporated into RNA in a DNA-dependent process, as indicated by the inhibition by actinomycin D. In addition, CTP and ATP were incorporated into the CCA end of mitochondrial tRNA. ATP was also incorporated into an unidentified acid-insoluble compound, which hydrolysed in alkali to a product that was not ATP, ADP or 5'- or 2(3')-AMP. Atractyloside inhibited the incorporation of ATP into RNA with 50% inhibition at 2-3nmol/mg of protein. The [(3)H]UTP-labelled RNA had peaks of 16S and 13S characteristic of mitochondrial rRNA. In addition a peak at 20-21S was observed as well as heterogeneous RNA sedimenting throughout the gradient. The synthesis of all these species was inhibited by actinomycin D, indicating that rat liver mitochondrial DNA codes for mitochondrial rRNA as well as other as yet unidentified species.


The measure of damage.

The measure of damage.


Antagonism of noradrenaline and histamine by desipramine in the isolated artery of the rabbit ear. 1. The effects of desipramine (DMI) were examined on the vasoconstrictor responses of the isolated perfused artery of the rabbit ear to noradrenaline (NA) and to histamine. Innervated and sympathetically denervated arteries were used.2. In innervated arteries, DMI in concentrations of 1 x 10(-8) to 1 x 10(-7)M enhanced the responses to NA; higher concentrations reduced the responses. In sympathetically denervated arteries, DMI caused only reduction of the responses to NA.3. Responses to histamine were reduced by DMI in both innervated and denervated arteries. DMI was considerably more potent as an antagonist of histamine than of noradrenaline.4. The reduction by DMI of the responses to NA and histamine in both innervated and denervated arteries was associated with a parallel shift to the right of the concentration-response curves of the agonist and a depression of the maximal response. These effects of DMI were reversible.5. Analysis of the data by the method of Arunlakshana & Schild (1959) showed the following: the antagonism of the action of NA by DMI on denervated arteries fulfilled the requirements for competitive antagonism; antagonism of the action of NA on innervated arteries was not competitive; antagonism of the actions of histamine on innervated and denervated arteries was not competitive.6. It is suggested that DMI antagonizes the action of NA and histamine on the perfused artery of the rabbit ear in two ways: (i) reversible specific antagonism which is competitive for NA and not competitive for histamine; (ii) reversible non-specific antagonism which is non-competitive for both agonists.


The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat. 1. A method for the measurement of anaphylactic bronchoconstriction in the rat is described.2. Dexamethasone inhibited this response in a dose-related manner.3. Disodium cromoglycate antagonized the response. A bell-shaped dose-response curve was obtained with peak activity at 1 mg/kg i.v.4. Meclofenamate was not active when given alone or in combination with dexamethasone.5. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.6. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea-pig and to human asthma are discussed.


The pattern of bacterial infection in bronchial diseases in Australia: a serological and bacteriological survey.


Mechanism of beta-blockade hypotension.

Mechanism of beta-blockade hypotension.


Pharmacology of recent beta-adrenoceptor stimulants.


Cardioselective beta-adrenergic blockade.


Cyclic adenosine monophosphate in human adipose tissue.


The nuclear submarine environment.

The nuclear submarine environment.


The effects of extended hypercapnia.

The effects of extended hypercapnia.


Which drug for alcohol withdrawal?

Which drug for alcohol withdrawal?


Long-term effects of facial injuries.

Long-term effects of facial injuries.


Microbiology of the submarine environment.


Restoration of teeth after facial injuries in road accidents.


Factors influencing placental steroidogenesis.


Catalase activity and red cell metabolism.


Enzymatic mechanisms of red cell adaptation to anemia.


Drugs used in the treatment of hypertension. 2.


Pharmacology of AH 5158; a drug which blocks both  - and  -adrenoceptors. 1. AH 5158 differs from conventional adrenoceptor blocking drugs in producing competitive blockade of both alpha- and beta-adrenoceptors.2. AH 5158 is 5-18 times less potent than propranolol in blocking beta-adrenoceptors. It resembles propranolol in its non-selective blockade of beta(1)-cardiac and beta(2)-vascular and tracheal adrenoceptors and in its lack of intrinsic sympathomimetic activity.3. AH 5158 is 2-7 times less potent than phentolamine in blocking alpha-adrenoceptors. AH 5158 itself is more active on beta- than alpha-adrenoceptors.4. Blockade of noradrenaline vasopressor responses by AH 5158 in anaesthetized dogs was dose-dependent up to 1 mg/kg but no further blockade was obtained with larger doses of AH 5158. ;Self-limiting' blockade was not observed in dogs pretreated with cocaine, or in untreated dogs if the vasopressor agent was oxymetazoline instead of noradrenaline. A possible cause of ;self-limiting' blockade is discussed.5. In doses higher than those required for either alpha- or beta-adrenoceptor blockade, AH 5158 produced effects on cardiac muscle that are attributable to membrane-stabilizing activity. This was manifested as a negative inotropic action in spinal dogs and in guinea-pig left atrial strips, as a negative chronotropic action in syrosingopine pre-treated dogs, and as an increase in the effective refractory period of guinea-pig left atrial strips. AH 5158 was 3-11 times less potent than propranolol in these tests.6. In open chest dogs AH 5158 resembled propranolol in reducing cardiac output, rate and contractility, effects which are attributable to beta-adrenoceptor blockade. The drug differed from propranolol in decreasing rather than increasing total peripheral resistance and in causing larger decreases in arterial blood pressure at equipotent beta-adrenoceptor blocking doses. These differences are attributable to the alpha-adrenoceptor blocking actions of AH 5158.7. In anaesthetized dogs, intravenously administered AH 5158 antagonized both catecholamine and ouabain-induced arrhythmias. Orally administered AH 5158 lowered systolic arterial pressure in conscious renal hypertensive dogs.8. These results show AH 5158 to possess a novel profile of activity. Possible uses of the drug in cardiovascular disorders such as hypertension, angina pectoris and cardiac arrhythmias are discussed.


Studies on the biosynthesis of 18-oxygenated steroids from exogenous corticosterone by domestic duck (Anas platyrhynchos) adrenal gland mitochondria.


A two-year comparison dental study of 132 Naval Reserve Recruits.


The disease of the NZB mouse. I. Examination of ovum fusion derived tetraparental NZB:CFW chimaeras.


Biochemical effects of 1,1-dichloroethylene in rats: comparison with carbon tetrachloride and 1,2-dichloroethylene.


New Congress president (James W. Rae, M.D.).


Enzyme systems for fatty acid synthesis.


Cholesterol 7 -hydroxylase in rat liver microsomal preparations. Subcellular fractions containing microsomes prepared from rat livers homogenized in the absence of EDTA catalysed the oxidation of cholesterol to 7alpha-hydroxycholesterol, 7-oxocholesterol, 7beta-hydroxycholesterol and 5alpha-cholestane-3beta,5,6beta-triol. These reactions required native protein, molecular oxygen and NADPH. It is suggested that these compounds are formed by a peroxidation analogous to the peroxidation of fatty acids catalysed by liver microsomal preparations. Incubations of [4-(14)C]cholesterol with microsomal preparations from rat liver homogenized in the presence of EDTA gave 7alpha-hydroxy[(14)C]cholesterol as the main product. This reaction required molecular oxygen and NADPH, and was inhibited by CO. The mass of 7alpha-hydroxycholesterol formed during the incubation was measured by a double-isotope-derivative dilution procedure. This procedure was used to assay the activity of cholesterol 7alpha-hydroxylase and to measure low concentrations of endogenous 7alpha-hydroxycholesterol in liver.


Generation of reducing potential in photosynthesis.


Flavoprotein semiquinone.

Flavoprotein semiquinone.


Studies on phosphatases of the mosquito Culex pipiens fatigans.


Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea.


Homoserine dehydrogenase of Serratia marcescens.


Malate metabolism in mycobacteria.

Malate metabolism in mycobacteria.


Isolation of a particulate (membrane) fraction from Mycobacterium smegmatis showing phosphorylation coupled to malate oxidation.


The selectivity of  -adrenergic compounds. II. Studies on the mimetic compound Salbutamol and the lytic compound practolol.


The interaction of rhodopsin with nucleotides.


Interaction of tolbutamide with phenothiazines and diphenhydramine.


Mechanism of stimulant effect of acetylcholine in isolated frog heart.


On the inducing activity of eucalyptol.

On the inducing activity of eucalyptol.


Alcoholics, heroin addicts and nonaddicts; comparisons on the MacAndrew Alcoholism Scale of the MMPI.


Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum. Treatment of rat spleen cells with cobra factor and fresh rat serum provided a simple, rapid means of functionally eliminating complement receptor lymphocytes. Cells able to differentiate into plaque-forming cells in a syngeneic, irradiated host were diminished, but cells able to induce a graft-versus-host reaction were not diminished. There was no effect on plaque-forming cells from an immune spleen.


Molecular symmetry and crystal packing of E. coli glutamine synthetase.


Relaxation studies on an allosteric enzyme: aspartokinase I-homoserine dehydrogenase I.


Neurotransmitters and hepatic failure.

Neurotransmitters and hepatic failure.


Photosynthetic properties of extracts of Anacystis nidulans prepared by lysozyme digestion.


On the psychopharmacology of beta adrenergic blockade.


Acute high altitude stress and enzyme activities in the rat adrenal medulla.


Purification and properties of extra- and intramitochondrial malate dehydrogenase (NADP; decarboxylating) from pig heart.


Early responses of liver to cortisone in alloxan-diabetic rats.


Additional immunochemical relationships of capsular polysaccharides of Klebsiella and pneumococci.


Cellular inflammatory responses of man to bacterial endotoxin: a comparison with PPD and other bacterial antigens.


The in vivo activity of in vitro immunized mouse thymocytes. II. Rejection of skin allografts and graft-vs-host activity.


The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices.


Citrate oxidation in the cytoplasmic fraction of rat brain.


Animal evolution in the field of synaptic substances.


Digitalis toxicity: drug interactions promoting toxicity and the management of toxicity.


Effect of adenine nucleotides and ATP-ase poisons on the rate of oxidation of pyridine nucleotides by kidney microsomes.


Cellular events in the induction and loss of tolerance to pneumococcal polysaccharides.


Metabolism of 3 -hydroxy-  5 - and 3-oxo-  4 -C 19  and C 21  steroids in human liver microsomes.


Direct current cardioversion in a case of congenital atrial flutter.


Utilization of a cyclopentane analog of glutamate (cis-1-amino-1,3-dicarboxycyclopentane) by glutamine synthetase.


Regulation and kinetics of glucose-6-phosphate dehydrogenase from Candida utilis.


Nicotinamide adenine dinucleotide glycohydrolases from Ehrlich ascites tumor cell nuclei: isolation, partial purification, and properties.


Nucleotide and phosphate regulation of glutamate oxidation in pig heart mitochondria by glutamate dehydrogenase (GDH).


Consequences of lysine oversynthesis in Pseudomonas mutants insensitive to feedback inhibition. Lysine excretion or endogenous induction of a lysine-catabolic pathway.


The electromechanochemical model of mitochondrial structure and function.


Epidemiological toxicology of pesticide exposure. Report of an International Workshop.


Australia antigen (hepatitis-associated antigen).


The binding of  -ketoglutarate in a binary complex and in a ternary complex with NADP +  by L-glutamate dehydrogenase.


Conversion of the red semiquinone of D-amino acid oxidase to the blue semiquinone by complex formation.


Patterns of psychotropic drug prescription in four midwestern state hospitals.


Cardiovascular effects of acebutolol (M & B 17803A), in exercising man; a comparative study with practolol and propranolol.


Glutamine synthetase, an enzyme characteristic of vertebrate systems in invertebrate tissues.


Mechanism of dominance of RNA-polymerase structural gene alleles causing sensitivity to antibiotics.


Salazopyrin metabolism in ulcerative colitis.


Erythrocytic methaemoglobin reductases of various mammalian species.


The effect of salazopyrin on water and electrolyte transport in the human colon measured in vivo and in vitro.


A comparative trial of prindolol, clonidine and carbamazepine in the interval therapy of migraine.


White norms and black MMPIs: a prescription for discrimination?


Protective effect of beta adrenoceptor blockade in experimental coronary occlusion in conscious dogs.


Barbiturates and meprobamate: decreases in cathecholamine turnover of central dopamine and noradrenaline neuronal systems and the influence of immobilization stress.


Bemegride-induced paroxysmal discharges in leech ganglion.


Purification and properties of nitrite reductase from spinach leaves.


The present and projected capabilities of the diving industry in the support of offshore petroleum production.


Some studies and comments on hepatic and extrahepatic microsomal toxication-detoxication systems. A limited discussion of some of the heterogeneities of these systems and of their responses to stimulation of enzyme "induction".


Kinetics of integration of transforming DNA in pneumococcus. Integration of donor genes, as measured by recovery of their transforming activity from eclipse in lysates of newly transformed cells of pneumococcus, has been followed at temperatures from 0 to 40 degrees . There is a lag in the recovery curve that is marker-dependent and increases as temperature falls. An Arrhenius plot of the rates shows a sharp break between 15 and 20 degrees . Brief exposure of the system to 37 degrees before incubation at 10 or 15 degrees removes the lag and raises the subsequent rate of recovery. This activation is unstable, however, and disappears when the cells are held at 0 degrees after the exposure at 37 degrees and before incubation at 15 degrees . The results are interpreted in terms of a reaction sequence A right harpoon over left harpoon B --> C, with activation energies for the first forward rate-constant of the order of 50 Cal/mol, for the second, 20-21 Cal/mol, and for the reverse reaction, less than 20 Cal/mol. The properties of the first step, including its marker dependence, are the same as those observed earlier for stabilization of donor markers against intracellular inactivation, and it is suggested they may reflect an activation of the recipient chromosome prerequisite to synapsis.


Changes in intrinsic circular dichroism of several homogeneous anti-type 3 pneumococcal antibodies on binding of a small hapten. Three homogeneous antibodies against the capsular polysaccharide of Type III pneumococci of similar specificities and affinities were purified from a single bleeding of an individual rabbit and fractionated by isoelectric focusing. A comparison of the circular dichroic spectra of the three antibodies revealed differences among them, although the spectra were generally similar to those obtained previously for heterogeneous rabbit antibodies [Cathou, R. E., Kulcycki, A., Jr. & Haber, E. (1968) Biochemistry 7, 3958]. On binding of the hexasaccharide, -[-->3)-beta-D-glucuronic acid-(1-->4)-beta-D-glucose-(1-](3)-->, significant changes in all three circular dichroic spectra were observed. Since the oligosaccharide alone shows no transitions above 220 nm, these spectral changes can be attributed to changes in the intrinsic optical activity of the antibodies. Calculated difference circular dichroism spectra (of antibody minus that of antibody-hapten complex) of the three antibodies are different from each other, and resemble spectra of tryptophan and tyrosine derivatives. These changes in optical activity can be ascribed to changes in the asymmetric environments of aromatic chromophores directly in the combining site and/or to changes in orientation inside or beyond the site. Since the hapten-antibody interactions are different in the three antibodies, as shown by the difference spectra, the structures of the combining sites are presumably also different. We have interpreted these observations to mean that a relatively simple ligand may be bound by several different complementary sites.


Synaptic contribution to the production of the plateau formation of the biopotential of somatic neuromembranes treated with convulsants: experiment on the identified giant neurone of a snail's subesophageal ganglion-complex.


The iso--and allotransplanted rat heart. Histological, electrocardiographic and serological observations.


Arbovirus epizootics involving man, mosquitoes and vertebrates at Lunyo, Uganda 1968.


Microbial metabolism of pyridinium compounds. Metabolism of 4-carboxy-1-methylpyridinium chloride, a photolytic product of paraquat. 1. A bacterium, Achromobacter D, isolated from garden soil by elective culture, utilized N-methylisonicotinic acid (4-carboxy-1-methylpyridinium chloride) as sole carbon source. 2. Extracts of N-methylisonicotinate-grown cells oxidized this substrate only after supplementation with a source of nicotinamide nucleotides and then consumed 1 mol of O(2) and released 1 mol of CO(2)/mol of N-methylisonicotinate supplied. 3. The N-methyl group of the substrate was released as methylamine whereas the five C atoms of the pyridine ring were accounted for as succinate and formate. The CO(2) evolved by extracts was believed to derive from the carboxyl group on C-4 of the heterocyclic ring. 4. The immediate precursor of the succinate end-product was succinic semialdehyde; the inducible nature of succinic semialdehyde dehydrogenase in N-methylisonicotinate-grown cells supported this finding. 5. There was no evidence for monohydroxylation of the ring, but the time sequence of the appearance of the end-products indicated that the oxygen-requiring, NADH-requiring and decarboxylation steps clearly preceded the formation of methylamine and succinate. 6. The results are consistent with the oxidative cleavage of a partially reduced heterocyclic ring followed by several hydrolytic and dehydrogenase steps resulting in the appearance of the end-products.


The cellular production of hydrogen peroxide. 1. The enzyme-substrate complex of yeast cytochrome c peroxidase is used as a sensitive, specific and accurate spectrophotometric H(2)O(2) indicator. 2. The cytochrome c peroxidase assay is suitable for use with subcellular fractions from tissue homogenates as well as with pure enzyme systems to measure H(2)O(2) generation. 3. Mitochondrial substrates entering the respiratory chain on the substrate side of the antimycin A-sensitive site support the mitochondrial generation of H(2)O(2). Succinate, the most effective substrate, yields H(2)O(2) at a rate of 0.5nmol/min per mg of protein in state 4. H(2)O(2) generation is decreased in the state 4-->state 3 transition. 4. In the combined mitochondrial-peroxisomal fraction of rat liver the changes in the mitochondrial generation of H(2)O(2) modulated by substrate, ADP and antimycin A are followed by parallel changes in the saturation of the intraperoxisomal catalase intermediate. 5. Peroxisomes supplemented with uric acid generate extraperoxisomal H(2)O(2) at a rate (8.6-16.4nmol/min per mg of protein) that corresponds to 42-61% of the rate of uric acid oxidation. Addition of azide increases these H(2)O(2) rates by a factor of 1.4-1.7. 6. The concentration of cytosolic uric acid is shown to vary during the isolation of the cellular fractions. 7. Microsomal fractions produce H(2)O(2) (up to 1.7nmol/min per mg of protein) at a ratio of 0.71-0.86mol of H(2)O(2)/mol of NADP(+) during the oxidation of NADPH. H(2)O(2) is also generated (6-25%) during the microsomal oxidation of NADH (0.06-0.025mol of H(2)O(2)/mol of NAD(+)). 8. Estimation of the rates of production of H(2)O(2) under physiological conditions can be made on the basis of the rates with the isolated fractions. The tentative value of 90nmol of H(2)O(2)/min per g of liver at 22 degrees C serves as a crude approximation to evaluate the biochemical impact of H(2)O(2) on cellular metabolism.


Neuronally mediated enzyme induction.

Neuronally mediated enzyme induction.


Factors influencing the development of the sympathetic nervous system: trans-synaptic regulation and the influence of nerve growth factor.


Adenosine 3':5'-cyclic monophosphate as a mediator in the action of neurohumoral agents.


The influence of chicken and mammalian luteinizing hormones on ovarian estrogen synthesis in the pullet (Gallus domesticus).


Effect of potassium ion concentration on cultured sympathetic ganglia: conclusions about trans-synaptic modulation.


The effects of cooling on electrical responses of goldfish (Carassius auratus) central nervous system.


Effects of cold exposure on urinary and adrenal catecholamines in a hibernator, the golden hamster.


Platelet factor 3 availability in bleeder swine.


A haematological study of the southern elephant seal, Mirounga leonina (linn.).


Neonatal hypothalamic and cerebral cortical tissue QO 2 .


Seasonal differences in resting metabolic rate of Alaskan ptarmigan.


Effect of aminophylline on blood platelet reactions.


Effects of cold exposure and seasonal acclimatization on protein and DNA synthesis in the rodent Microtus pennsylvanicus.


Seasonal changes in the fatty acid spectrum in the hibernating and non-hibernating ground squirrel Citellus tridecemlineatus.


Evidence for xanthine dehydrogenase action on lipid metabolism in Artemia salina (L.).


Ascorbic acid levels in mammalian tissues and its metabolic significance.


Metabolic heat production of parents and offspring.


Relationship between blood levels of testosterone and accessory sex gland weights in impala (Aepyceros melampus).


Conversion of 3 ,7 -dihydroxychol-5-enoic acid to allochenodeoxycholic acid by carp liver preparation.


Red cells and their enzymes.

Red cells and their enzymes.


Causalgia and transthoracic sympathectomy.


The influence of donor-recipient histocompatibility on the efficacy of anti-lymphocyte serum.


Infective endocarditis. An African experience.


Cellular location of the uptake of some amino acids into the rabbit retina.


Rheumatic and collagen involvement of the heart.


Physician assistant.

Physician assistant.


Health care training of the physician assistant: a proposed cardiopulmonary program.


Pathology of angina pectoris.

Pathology of angina pectoris.


Abnormalities of left ventricular function associated with the anginal state.


Medical management of angina pectoris.

Medical management of angina pectoris.


Serological comparisons among Hart Park virus and strains of Flanders virus. The antigenic relationships among Hart Park (HP) virus strain AR 70, Flanders virus strain 61-7484, and other related strains were investigated. Strains AR 70 and 61-7484 were shown to be antigenically related but different from each other in neutralization, complement fixation, and double-diffusion tests. Two strains isolated in Texas and one strain each, isolated in Illinois and Florida, appeared to be closely related if not identical to Flanders virus (61-7484) and antigenically related but different from HP virus AR 70. Ten additional strains isolated in 10 different states were compared to the two prototype strains. Seven of the 10 could not be distinguished from Flanders virus, and all 10 strains were different from HP virus. The results indicate that a virus-type consisting of viruses antigenically related if not identical to Flanders virus is widely distributed within the United States, whereas HP virus is antigenically related but different from this type.


Mechanisms of hormonal induction of enzymes.


The surgical assistant--new on the OR team.


Psychosomatic medicine. XI. Gynaecology.


Mosquito blood meals: identification by a fluorescent antibody method.


Significance of cell interactions in production of graft versus host splenomegaly.


Regulation of isocitrate metabolism in peroxisomes in Tetrahymena pyriformis.


Immobilized pyridine nucleotide transhydrogenase from Azotobacter vinelandii: resolution and some properties.


Effect of ascorbic acid on tyrosine hydroxylase activity in vivo.


Respiration-coupled glucose transport in membrane vesicles from Azotobacter vinelandii.


Quantitative studies of the spatial distribution of synaptic vesicles within normal and degenerating motor axons of the locust, Schistocerca gregaria.


The oxygen tensions of the extraembryonic fluids of the chick embryo.


Anterior hypothalamic-preoptic lesions impair normal thermoregulation in house sparrows.


Carbohydrases of the digestive gland and the crystalline style of the Atlantic deep-sea scallop (Placopecten magellanicus, gmelin).


Heat loss from small birds: analogy with Ohm's law and re-examination of the "Newtonian model".


Effects of acetazolamide, betazole, and HCO -  3  on the acid-base transport of the tortoise urinary bladder, Damonia subtrifuga.


Function of the omasum in several ruminant species.


A comparative study of intestinal phlorizin hydrolase in various animal species.


The effects of dietary protein content on water requirements and ammonia excretion in pigeons, Columba livia.


Thermoregulatory ability and the thyroid gland: their development in embryonic Japanese quail (Coturnix c. japonica).


Digestion of sugars in the crop.

Digestion of sugars in the crop.


Adaptation of primary gustatory nerve responses in the frog.


Monoamine-containing nervous fibres in foregut and salivary gland of the desert locust, Schistocerca gregaria Forskal (Orthoptera, Acrididae).


Hematologic parameters of the nine-banded armadillo, Dasypus novemcinctus.


Does the devil sweat?

Does the devil sweat?


Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y).


Lack of effect of calcitonin on renal function in the elasmobranch, Squalus acanthias.


Amiloride and sodium fluxes across fish gills in fresh water and in sea water.


Temperature-induced delays in prolactin-initiated second metamorphosis of the newt (Notopthalamus viridescens).


Heart rates in freely diving Weddell Seals, Leptonychotes weddelli.


The sexual cycle of male bats: changes of testicular lactate dehydrogenase isoenzymes.


A new isolated perfused gill preparation for the study of the mechanisms of ionic regulation in teleosts.


Comparative study of concentrative prostaglandin accumulation by various tissues of mammals and marine vertebrates and invertebrates.


Fine structure of normal and degenerating motor axons and nerve-muscle synapses in the locust, Schistocerca gregaria.


Concerning the induction of dormancy in spores of Agaricus bisporus.


Pyridine isosteres of the  -adrenergic antagonists, 2-(p-nitrophenyl)-1-isopropylamino-2-ethanol and 3-(p-nitrophenoxy)-1-isopropylamino-2-propanol.


Arbovirus activity in Israel.

Arbovirus activity in Israel.


25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties.


Reaction between reduced diphosphopyridine nucleotide and glutamate oxalacetate transaminases.


Investigation of the component reactions of oxidative sterol demethylation. Role of an endogenous microsomal source of reducing equivalents.


Isolation and characterization of glutamine synthetase from chicken neural retina.


Urocanase of Pseudomonas putida. Subunit structure and origin of enzyme-bound  -ketobutyrate.


Toxic thrombocytopenic purpura following use of a nonprescription medication.


Some aspects of the control of dehydroepiandrosterone synthesis in the human adrenal gland in vitro.


A comparison of ipecac syrup and apomorphine in the immediate treatment of ingestion of poisons.


A blueprint for pediatric health manpower for the 1970's. The 1972 George Armstrong Lecture.


Planning for pediatric care.

Planning for pediatric care.


Enzyme defect in saccharopinuria.

Enzyme defect in saccharopinuria.


Studies with cholecystokinin in vitro. 3. Mechanism of the effect on the isolated rabbit gall bladder strips.


Congenital deficiencies of the thymus dependent system of cellular immunity. Treatment by transplantation of bone-marrow or fetal tissues.


Regulation of catecholamine turnover by variations of enzyme levels.


Comparison between the effect of neuronal activity and nerve growth factor on the enzymes involved in the synthesis of norepinephrine.


Regulation of catecholamine metabolism in the sympathetic nervous system.


Changes in tyrosine hydroxylase and dopa decarboxylase induced by pharmacological agents.


Extramitochondrial fatty acid synthesis in Ehrlich ascites tumor cells propagated in vitro and in vivo.


Direct cardiac action of E. coli endotoxin.


Resolved: that the present system of prenatal care is inadequate. A debate.


Some applications of insolubilised cofactors to the purification of pyridine nucleotide-dependent dehydrogenases.


Ammonia inhibition of the general amino acid permease and its suppression in NADPH-specific glutamate dehydrogenaseless mutants of saccharomyces cerevisiae.


NADPH-dependen lipid peroxidation catalyzed by purified NADPH-cytochrome C reductase from rat liver microsomes.


Evidence for the presence of an iron sulphur protein in rat kidney cortex microsomes.


Regulation by ammonia of nitrate reductase synthesis and activity in Chlamydomonas reinhardi.


A long-term pilot study of pipothiazine palmitate in chronic schizophrenia.


The enzymatic oxidation of porphobilinogen.


Allosteric inhibition of NADP-linked malic enzyme from an extreme halophile by acetyl-CoA.


A fluorescent modification of flavin adenine dinucleotide.


Mutual inhibition between NADH oxidase and succinoxidase activities in respiring submitochondrial particles.


Amino acid oxidase in leukocytes: evidence against a major role in phagocytosis. The addition of either d- or l-amino acids fails to increase hexose monophosphate shunt activity of resting or phagocytizing neutrophils. This is presumptive evidence against a major role for amino acid oxidase in the bactericidal activity of the cell.


Hypogonadotropic eunuchoidism. I. Clinical study of the mode of inheritance.


Hypogonadotropic eunuchoidism. II. Gonadal responsiveness to exogenous gonadotropins.


Episodic and distributive nursing in an emergent curricular plan.


Water relations of sugar-tolerant yeasts: the role of intracellular polyols.


Nursing education and practice: putting it all together.


Research in nursing as input to educational programs.


Decisions and directions: determinations no longer to be deferred.


Toward a full profession of nursing: the challenge of the eductor's role.


Eleven months to Ennistymon.

Eleven months to Ennistymon.


You can't get there from here: articulation in nursing education.


Help for the hyperkinetic child in school.


Spontaneous thymidine incorporation by leukocytes or renal transplant recipients.


Vascular surgery.

Vascular surgery.


A review of "blue bottle" stings on an eastern suburbs beach.


Medical approach to ophthalmopathy of Graves' disease.


Influence of temperature on the sensitivity of the  -receptors and the contractility of guinea-pig atrium.


Isolation of A2-Singapore-57 influenza virus V and S antigens by isoelectric focusing.


The fine structure of the gonads in the complete form of testicular feminization syndrome.


Psychological reaction to therapeutic abortion. II. Objective response.


The response of the unanesthetized sheep fetus to sympathomimetic amines and adrenergic blocking agents.


Effect of beta-adrenergic blocking agents on the spontaneous motility of mice.


Chlorcyclizine-induced changes in the epididymides and the prostatic complex of rats.


Adenine nucleotide concentration and redox value of human spermatozoa.


The effect of burimamide on gastric secretion in man.


The effects of early experimental cryptorchidism and subsequent orchidopexy on maturation of guinea-pig testicles.


Diamine oxidase and histamine in the small intestine after experimental ischaemia.


A new ophthalmological examination unit for clinical assistants.


Formation in vitro of 5alpha-dihydrotestosterone and other 5alpha-reduced metabolites of 3H-testosterone by the seminiferous tubules and interstitial tissue from immature and mature rat testes.


Properties of purified pneumococcal hemolysin. With a purified preparation of pneumococcal hemolysin, a sigmoid relationship was found to exist between lysin concentration and hemolytic activity. Hemolysis was inhibited by a high ratio of erythrocytes to lysin, suggesting a multi-hit mechanism of action. Reaction rate decreased rapidly with time, possibly due to competition between ghosts and unlysed erythrocytes for fixation of lysin. The effects of pH and various agents on the processes of lysin adsorption and hemoglobin release were determined. The pneumococcal preparation did not possess nicotinamide adenine dinucleotide glycohydrolase activity.


Target-organ treatment of neurotropic virus disease with interferon inducers. Interferon inducers were used against vaccinial encephalitis to study the target-organ treatment of neurotropic disease and to correlate interferon levels and the antiviral state following such treatment. A 45-mug amount of statolon, 30 mug of polyribinosinic-polyribocytidylic acid complex (poly I.poly C), or 0.0154 HA unit of Sendai virus given intracerebrally protected 100% of mice challenged the next day with 1,000 median lethal doses (LD(50)) of vaccinia virus. Significant protection against 1,000 LD(50) of vaccinia virus persisted for 1, 4, or 3 weeks after poly I.poly C, statolon, or Sendai virus (154 HA units), respectively. These doses of poly I.poly C and statolon were also used to study postinfection treatment. Mice challenged with 1, 10, 100, or 1,000 LD(50) were treated intracerebrally with poly I.poly C or statolon 24 or 48 hr later. Significant increases in survival time were seen in mice challenged with 1 to 100 LD(50) of vaccinia virus and treated 24 hr later. At challenges of 10 or 100 LD(50), statolon was more effective than poly I.poly C in increasing survival times. When treatment was delayed until 48 hr after infection, significant increases in survival time occurred only when the challenges were in the range of 1 to 10 LD(50), with poly I.poly C and statolon being equally effective. Interferon was measured by Finter's dye-uptake method, with L-929 cells and Semliki Forest virus. Poly I.poly C, statolon, or Sendai virus, given intracerebrally to mice, produced serum interferon peaks of 5,120 units/ml at 2 hr, 2,560 units/ml at 12 hr, or 320 units/ml at 18 hr, respectively. Corresponding brain interferon peaks were 640 units/g at 2 hr, 640 units/g at 4 to 24 hr, and 960 units/g at 72 hr.


Caries-free teeth in the absence of the fluoride ion.


Dental injuries in Seattle's public school children; school year 1969-70.


Histochemical determination of neurotransmitter distribution.


Sedation of young children for electric response audiometry (ERA). Summary of a symposium.


Resistance of bacteriophage PBS2 infection to rifampicin, an inhibitor of Bacillus subtilis RNA synthesis.


Antihypertensive drugs in the treatment of hypertension.


Experimental pneumococcal infection in embryonated eggs previously infected with influenza C virus. Cumulative mortality rates for embryonated eggs, compiled for a variety of pneumococcal strains, indicated a uniformly high degree of virulence. Based on median lethal dose values for combined infection with influenza C virus and single infection with pneumococcus, it is difficult to conclude that pneumococcal virulence is enhanced in combined infection. However, there was a significant increase in mortality during the first 24 hr following combined infection. A significantly greater in vitro growth rate for pneumococcus was shown in amniotic fluid from virus-infected embryonated eggs. Microscopy study of selected embryos revealed the absence of a discernible inflammatory reaction during the first 24 hr. From 48 through 96 hr after inoculation, inflammatory reactions were restricted to the upper and lower respiratory tract and consisted of a polymorphonuclear leukocyte infiltration in response to the localization of pneumococci in the paranasal sinuses, bronchi, alveolar ducts, and alveolar spaces. Extensive, severe inflammatory reactions were more frequently encountered in the combined infection. The various phases from early exudation to eventual resolution, which characterize pneumococcal pneumonia in the human host, were in clear evidence following both the single and combined infection of the chick embryo.


Nitrogen metabolism and protein synthesis during pneumococcal sepsis in rats. Markedly increased synthesis of alpha(2) and beta globulins and alpha(1), alpha(2), and beta glycoglobulins occurs during pneumococcal sepsis in the rat simultaneously with decreased albumin formation, diminished tritiated leucine incorporation into muscle protein, and enhanced excretion of nitrogen. This augmented synthesis of specific serum proteins does not become evident until fever and bacteremia develop, and it appears to be a fundamental aspect of host response to a proliferating bacterial infection in that it occurs even in rats fed a protein-deficient (6% protein) diet after weaning and before exposure to Diplococcus pneumoniae. Although amino acid catabolism, in general, appears to be increased during infection, tryptophan degradation via the kynurenine pathway, as assessed by measuring diazotizable urinary metabolites, changes little or is, at times, significantly less than in control animals. Coincidentally, functional tryptophan oxygenase activity decreases at 16 hr after exposure. Total tryptophan oxygenase activity, however, is unchanged.


Nicotinamide adenine dinucleotide glycohydrolase activity in guinea pig polymorphonuclear leukocytes. An enzyme is present in extracts of guinea pig polymorphonuclear leukocytes which can catalyze the hydrolysis of pyridine nucleotides. The enzyme is equally active toward nicotinamide adenine dinucleotide (NAD) or NAD phosphate, has an acid pH optimum, and is inhibited by either nicotinamide or isonicotinic acid hydrazide. This enzyme might be involved in the regulation of the pyridine nucleotide concentration within the leukocyte.


Growth of Venezuelan encephalitis virus in embryonic cell cultures of wild birds. Primary embryonic cell cultures made from nine species of wild and domestic birds were infected with Venezuelan encephalitis virus and reproduced each strain to moderately high levels.


Anti-gamma globulins and chronic infection: comparative studies of the immune response to various bacteria and gamma globulin preparations. A study of the relationship of clinical states associated with prolonged infection (bacterial endocarditis and osteomyelitis) and generation of serum anti-gamma globulins was made with particular reference to quantitative amounts of staphylococcal protein A in various infecting strains. No correlation between individual strain amounts of protein A and presence of anti-gamma globulins was detected. Thirty-eight rabbits were immunized intravenously with various strains of bacteria (Staphylococcus aureus, enterococci, Streptomyces viridans, pneumococci, pseudomonas, and Escherichia coli) for periods of 6 weeks, and antibacterial as well as anti-gamma globulin antibodies were assayed. No single group or strain of bacteria stood out as being more prone to produce anti-gamma globulins than others tested. Most rabbits developed anti-gamma globulins reacting with human gamma globulins, whereas the specificity for rabbit gamma globulin appeared more restricted. In 16 rabbits immunized with eight different strains of S. aureus, quantitative elevation of serum gamma globulin above 2.5 g per 100 ml often seemed to be correlated with presence of detectable serum anti-gamma globulins. By contrast 15 rabbits immunized with autologous or isologous rabbit gamma globulins in many instances developed extremely high titers of anti-gamma globulins showing primary specificity for human rather than rabbit gamma globulin. These studies further amplify the remarkably heterogeneous anti-gamma globulin reactivity associated with various types of immune response.


Work study in the assessment of the effects of phenothiazines in schizophrenia.


Changes in statistical parameters during facilitation at the crayfish neuromuscular junction. 1. Transmitter release at excitatory neuromuscular junctions of the crayfish was studied at different frequencies of stimulation ranging from 1/sec to 20/sec.2. Over this frequency range the average number of quanta released per stimulus (m) increased with frequency by a factor of 6-7.3. Analysis of the fluctuations in quantal release using binomial statistics indicated that the increase in m was associated with increase in the average quantal release probability (p) at stimulation frequencies between 5/sec and 20/sec. Between 1/sec and 5/sec there was an apparent increase in the number of quanta available for release (n).


The effects of calcium and magnesium on statistical release parameters at the crayfish neuromuscular junction. 1. Transmitter release at excitatory neuromuscular junctions of crayfish muscle was studied at low temperature by recording synaptic potentials with extracellular micro-electrodes.2. Increasing the Ca concentration in the bathing solution produced an increase in the average number of quanta released per nerve stimulus (m). Increasing the Mg concentration resulted in a decrease in m.3. Statistical analysis of fluctuations in the quantal release from trial to trial, assuming binomial statistics, indicated that both the changes in m were due to changes in the average quantal release probability (p).


Rejection of marrow allografts: importance of H-2 homozygosity of donor cells.


Treatment of hyperacute graft-versus-host disease in mice with cytosine arabinoside.


Comparative effects of selected cytotoxic agents on transplanted hematopoietic cells.


Attempts to demonstrate an in vivo role for serum blocking factors in tolerant mice.


Allotype synthesis by transplanted embryonic spleen cells in chickens.


Antibody production in thymectomized mice with implants of rabbit tonsillar tissue.


MEDEX--an operational and replicated manpower program: increasing the delivery of health services.


Some cardiac metabolic and haemodynamic alterations due to adrenergic beta-receptor blockade.


Auditory signal detection in paranoid and nonparanoid schizophrenics.


Propiomazine-induced acceleration of mammary involution in mice.


Lidoflazine: a new drug in the treatment of angina pectoris.


Use of physician's assistants in Gilchrist County, Florida.


Overloaded skeletal muscles of a nonhuman primate (Galago senegalensis).


Effect of alpha adrenergic blocking agents on myocardial toxicity of cardiac glycosides in guinea-pigs.


General practice and principles for pondering.


An attempt to elucidate the central depressive action of Tempidon.


Acid and alkaline phosphatase levels in various tissues of a lizard during activity and hibernation.


Studies on esterases levels in various tissues of Uromastix Hardwickii during activity and hibernation.


Differential effect of ethidium bromide and cytosine arabinoside on mitochondrial and nuclear DNA synthesis in HeLa cells.


In vivo methylation of DNA in different organs of rat at various ages.


Regeneration through peripheral nerve allografts. An electrophysiological and histological study following the use of immunosuppressive therapy.


Specific cleavage between variable and constant domains of rabbit antibody light chains by dilute acid hydrolysis.


Reiter's syndrome treated with methotrexate.


EKG of the month.

EKG of the month.


The private physician's role in venereal disease control.


Selected findings of the Ten-State Nutrition Survey.


Underachievement and some associated syndromes.


A total emergency medical service system for Illinois.


Programs of USDA's Food and Nutrition Service.


Maternal death study no. 8.

Maternal death study no. 8.


Operation for lymphedema.

Operation for lymphedema.


ISMS recommendations on health care licensure.


The 50 per cent maximum tax on earned income.


Be your own tax collector.

Be your own tax collector.


The view box.

The view box.


Recommendations on smallpox immunization.


Venereal disease today. I. Gonorrhea.

Venereal disease today. I. Gonorrhea.


Epizootiology of Venezuelan equine encephalomyelitis in the Americas.


Septic conditions of the equine foot.

Septic conditions of the equine foot.


The binding of cytochrome b 5  to liver microsomes.


p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Reactivity with oxygen.


Fatty acid synthetases in Euglena gracilis.


Studies on nicotinamide adenine dinucleotide phosphate reductase of spinach chloroplasts.


Gel filtration of the sperm attractants of some marine hydrozoa.


In vitro fertilization and capacitation-like interaction in the hydroid Campanularia flexuosa.


Microbodies in Leydig cell tumors of rat testis.


The in vitro interconversion by mercaptans of type I glucose 6-phosphate dehydrogenase isozymes of rat.


On the function of central catecholamine neurons--their role in cardiovascular and arousal mechanisms.


Interactions of digitoxigenin and digoxigenin with cytochrome P-450.


Comparing MMPI statements and mental status items.


The psychology of hallucinogenic drug discontinuers.


The distribution in the methylobacteria of some key enzymes concerned with intermediary metabolism.


Lipid peroxidation during enzymatic iodination of rat liver endoplasmic reticulum.


The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans.


Effects of denervation on the activities of some tricarboxylic acid-cycle-associated dehydrogenases and adenine-metabolizing enzymes in rat diaphragm muscle. 1. The activity of several tricarboxylic acid-cycle-associated dehydrogenases, adenine-metabolizing enzymes and glutathione reductase and the content of myoglobin were measured in rat diaphragm muscle after unilateral nerve section. 2. Consistent with morphological disintegration of the mitochondria there was a rapid diminution in activity of NAD- and NADP-linked isocitrate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. 3. Creatine phosphokinase and adenylate kinase, by contrast, showed little change in activity; adenylate deaminase and glutathione reductase activities increased during the hypertrophic phase. The concentration of myoglobin at first declined, then increased again. 4. The distribution of enzymes between the left and right hemidiaphragms was found not to be uniform. 5. Activities of adenine-metabolizing enzymes in the diaphragm were as great as in white muscle. It is suggested that their reputedly lower activities in red muscle properly refer to muscle containing a high proportion of intermediate fibres, which is not the case with diaphragm. 6. The possible causes of the transient hypertrophy after nerve section are discussed.


Purification and properties of Penicillium glucose 6-phosphate dehydrogenase. 1. Glucose 6-phosphate dehydrogenase was isolated and partially purified from a thermophilic fungus, Penicillium duponti, and a mesophilic fungus, Penicillium notatum. 2. The molecular weight of the P. duponti enzyme was found to be 120000+/-10000 by gelfiltration and sucrose-density-gradient-centrifugation techniques. No NADP(+)- or glucose 6-phosphate-induced change in molecular weight could be demonstrated. 3. Glucose 6-phosphate dehydrogenase from the thermophilic fungus was more heat-stable than that from the mesophile. Glucose 6-phosphate, but not NADP(+), protected the enzyme from both the thermophile and the mesophile from thermal inactivation. 4. The K(m) values determined for glucose 6-phosphate dehydrogenase from the thermophile P. duponti were 4.3x10(-5)m-NADP(+) and 1.6x10(-4)m-glucose 6-phosphate; for the enzyme from the mesophile P. notatum the values were 6.2x10(-5)m-NADP(+) and 2.5x10(-4)m-glucose 6-phosphate. 5. Inhibition by NADPH was competitive with respect to both NADP(+) and glucose 6-phosphate for both the P. duponti and P. notatum enzymes. The inhibition pattern indicated a rapid-equilibrium random mechanism, which may or may not involve a dead-end enzyme-NADP(+)-6-phosphogluconolactone complex; however, a compulsory-order mechanism that is consistent with all the results is proposed. 6. The activation energies for the P. duponti and P. notatum glucose 6-phosphate dehydrogenases were 40.2 and 41.4kJ.mol(-1) (9.6 and 9.9kcal.mol(-1)) respectively. 7. Palmitoyl-CoA inhibited P. duponti glucose 6-phosphate dehydrogenase and gave an inhibition constant of 5x10(-6)m. 8. Penicillium glucose 6-phosphate dehydrogenase had a high degree of substrate and coenzyme specificity.


The control of nucleic acid and nicotinamide nucleotide synthesis in regenerating rat liver. 1. The effect of injecting nicotinamide on the incorporation of [(14)C]orotate into the hepatic nucleic acids of rats after partial hepatectomy was investigated. 2. At 3h after partial hepatectomy the rapid incorporation of [(14)C]orotate into RNA, and at 20h after partial hepatectomy the incorporation of [(14)C]orotate into both RNA and DNA, were inhibited in a dose-dependent fashion by the previous injection of nicotinamide. 3. The injection of nicotinamide at various times before the injection of [(14)C]orotate at 20h after partial hepatectomy revealed an inhibition of the incorporation of orotate into RNA and DNA which was non-linear with respect to the duration of nicotinamide pretreatment. 4. The induction of a hepatic ATP depletion by ethionine demonstrated that the synthesis of hepatic NAD and NADP in partially hepatectomized rats was more susceptible to an ATP deficiency than in control rats. 5. The total hepatic activity of ribose phosphate pyrophosphokinase (EC 2.7.6.1) was assayed at various times after partial hepatectomy and found to be only marginally greater than the maximum rate of hepatic NAD synthesis induced in vivo by nicotinamide injection between 12 and 24h after partial hepatectomy. 6. It is suggested that a competition exists between NAD synthesis and purine and pyrimidine nucleotide synthesis for available ATP and particularly 5-phosphoribosyl 1-pyrophosphate. In regenerating liver the competition is normally in favour of the synthesis of nucleic acid precursors, at the expense of NAD synthesis. This situation may be reversed by the injection of nicotinamide with a subsequent inhibition of nucleic acid synthesis.


Protein fluorescence of nicotinamide nucleotide-dependent dehydrogenases. 1. The decrease in the protein fluorescence (F) of Neurospora crassa glutamate dehydrogenase is linearly related to the increase in the fraction of the coenzyme sites occupied by NADPH (alpha) at pH6.35. Under these conditions NADPH causes this enzyme to dissociate to monomers. 2. There is a non-linear relationship of F to alpha for NADH binding to give the alcohol dehydrogenase-NADH-isobutyramide complex, the l-glycerol 3-phosphate dehydrogenase-NADH complex and the bovine glutamate dehydrogenase-NADH-glutamate complex. The non-linearity is accurately represented by F=[1-alpha(1-x)](n) where n is the number of NADH-binding sites per protein molecule. 3. The co-operative binding of GTP to bovine glutamate dehydrogenase in the presence of NADH gives a linear relationship between F and alpha. 4. The prediction from the equation F=[1-alpha(1-x)](n) that initial tangents to non-linear protein-fluorescence-quenching curves will intercept the fluorescence when alpha=1 at a value of total ligand concentration less than the sum of the concentration of binding sites in the solution plus the dissociation constant of ligand is quantitatively fulfilled. 5. Non-linear protein-fluorescence titrations may be used to obtain information about the distribution of ligand among the protein molecules in solution.


Pentose cycle and reducing equivalents in rat mammary-gland slices. 1. Slices of mammary gland of lactating rats were incubated with glucose labelled uniformly with (14)C and in positions 1, 2, 3 and 6, and with (3)H in all six positions. Glucose carbon atoms are incorporated into CO(2), fatty acids, lipid glycerol, the glucose and galactose moieties of lactose, lactate, soluble amino acids and proteins. C-3 of glucose appears in fatty acids. The incorporation of (3)H into fatty acids is greatest from [3-(3)H]glucose. (3)H from [5-(3)H]glucose appears, apart from in lactose, nearly all in water. 2. The specific radioactivity of the galactose moiety of lactose from [1-(14)C]- and [6-(14)C]-glucose was less, and that from [2-(14)C]- and [3-(14)C]-glucose more, than that of the glucose moiety. There was no randomization of carbon atoms in the glucose moiety, but it was extensive in galactose. 3. The pentose cycle was calculated from (14)C yields in CO(2) and fatty acids, and from the degradation of galactose from [2-(14)C]glucose. A method for the quantitative determination of the contribution of the pentose cycle, from incorporation into fatty acids from [3-(14)C]glucose, is derived. The rate of the reaction catalysed by hexose 6-phosphate isomerase was calculated from the randomization pattern in galactose. 4. Of the utilized glucose, 10-20% is converted into lactose, 20-30% is metabolized via the pentose cycle and the rest is metabolized via the Embden-Meyerhof pathway. About 10-15% of the triose phosphates and pyruvate is derived via the pentose cycle. 5. The pentose cycle is sufficient to provide 80-100% of the NADPH requirement for fatty acid synthesis. 6. The formation of reducing equivalents in the cytoplasm exceeds that required for reductive biosynthesis. About half of the cytoplasmic reducing equivalents are probably transferred into mitochondria. 7. In the Appendix a concise derivation of the randomization of C-1, C-2 and C-3 as a function of the pentose cycle is described.


16-unsaturated C 19  3-oxo steroids as metabolic intermediates in boar testis. 1. The formation of the two 16-unsaturated alcohols 5alpha-androst-16-en-3alpha-ol and 5alpha-androst-16-en-3beta-ol from [5alpha-(3)H]5alpha-androst-16-en-3-one has been demonstrated in boar testis homogenates. 2. The optimum yield (23%) of the 3alpha-alcohol was obtained in the presence of NADPH, whereas that for the 3beta-alcohol (74%) was obtained when NADH was the added cofactor. 3. The two alcohols were not interconvertible. 4. Prolonged storage of boar testis tissue at -20 degrees C abolished the ability to form all androst-16-enes except androsta-4,16-dien-3-one from [4-(14)C]progesterone. 5. The production of 5alpha-androst-16-en-3-one and the two alcohols from [7alpha-(3)H]androsta-4,16-dien-3-one only occurred when fresh tissue was used, whereas reduction of [5alpha-(3)H]5alpha-androst-16-en-3-one was unaffected by storage of testis at -20 degrees C. 6. NADPH was the preferred cofactor for the reduction of androsta-4,16-dien-3-one. 7. The previously established conversion of androsta-5,16-dien-3beta-ol into androsta-4,16-dien-3-one was shown to be reversible, NADH and NADPH being equally effective cofactors. 8. Pathways of biosynthesis of 5alpha-androst-16-en-3alpha- and 3beta-ols, with the C(19) 3-oxo steroids as intermediates, are presented.


Selective  -adrenergic myocardial stimulant.


Comparative study of propranolol and practolol with non-invasive methods in essential circulatory hyperkinesis.


Clinical pharmacological evaluation of beta-receptor antagonists. I. The effect of propranolol, oxprenolol, alprenolol on some central circulatory parameters in patients with essential circulatory hyperkinesis (ECH).


Aseptic necrosis of the first metatarsal.


All-weather track syndrome.

All-weather track syndrome.


Drug therapoy of clinical depressions--current status and implications for research on neuropharmacology of the affective disorders.


Mechanism of pressor effect of 5,6-dihydroxytryptamine in pithed rats.


Double peaked positive chronotropic response of the isolated blood-perfused S-A node to caffeine.


Anaesthesiological aspects of the operative treatment of phaeochromocytoma.


Prevention of recurrent nosebleeds in children. Some practical suggestions.


Serum -glytamyl transpeptidase activity in liver disease. Serum gamma-glutamyl transpeptidase (GGT) activity correlates closely with the activities of alkaline phosphatase (ALP) and 5'-nucleotidase (5NT) in various forms of liver disease. Maximum elevations of all three enzyme activities are observed in diseases which particularly affect the biliary tract. Compared with the other two enzymes GGT is generally increased to a greater extent and is thus the most sensitive indicator of biliary-tract disease, while estimations of serum GGT are more reproducible than those of 5NT. However, a group of patients who had been treated with phenytoin and barbiturates were found to have elevated serum GGT activities without any other evidence of liver disease. The apparent effect of certain drugs on serum GGT activity indicates the need for caution in interpreting the results of this test.


Report on symposium on atherosclerosis. 48th annual meeting of the American Association of Neuropathologists.


Effect on dental caries of self-application of acidulated phosphate fluoride paste and gel.


Review of 1972 news.

Review of 1972 news.


Bioassay determination of isecticide residues in alfalfa.


Studies of calcium influx into squid giant axons with aequorin.


Practolol in the treatment of tachyarrhythmias in patients with bronchial asthma.


International Orthodontic Congress to be a major educational event.


The sympathetic nervous system and the regulation of cerebral blood flow in man.


Site of the biosynthesis of CDP-diglyceride in plant mitochondria.


Increased "malic enzyme" activity during adaptation to a low protein diet.


Photochemical activities of a particle fraction P 1  obtained rom the green alga Chlorella fusca.


The effects of beta-blockade on left ventricular performance in experimental halothane anaesthesia.


Reaction mechanism of L-glutamate dehydrogenase. Characterization of optical and kinetic properties of various enzyme-reduced-coenzyme complexes.


Fast-kinetic studies of the oxidative deamination of glutamate catalyzed by glutamate dehydrogenase.


Validity of the 16 Pf and the MMPI in a mental hospital setting.


Over-the-counter daytime sedatives. A controlled study.


Sensitivity to azathioprine.

Sensitivity to azathioprine.


Functional ethology and the human sciences.


The prostaglandins.

The prostaglandins.


Behavioural analysis of the monkey's visual nervous system.


The effect of a new adrenergic beta 2 -receptor-stimulating agent (rimiterol, R798) in patients with chronic obstructive lung disease.


Viral hepatitis: current concepts.

Viral hepatitis: current concepts.


Osteoporotic bone disease in the pyridoxine-deficient rat.


The electron transport system in nitrogen fixation by azotobacter. IV. Some oxidation-reduction properties of azotoflavin.


Coenzyme specificity of dehydrogenases and fermentation of pyruvate by clostridia.


Syrup of ipecac as an emetic in the cat.


Transformation and deoxyribonucleic acid size: extent of degradation on entry varies with size of donor. The fate of label introduced as donor deoxyribonucleic acid (DNA) into competent cells of Diplococcus pneumoniae was determined immediately after entry at 25 C, as a function of the size of the donor DNA. Part of the label is found to be acid soluble, part has been incorporated into chromosomal DNA, apparently through reincorporation of degraded donor DNA, and part is found in single strands of length smaller than that of the input donor DNA strands. The last fraction apparently constitutes the precursor for integration of intact donor genetic markers and is referred to as the intact fraction. For large donor DNA the intact fraction contains over 80% of the total intracellular label, but the median strand length has been reduced to 2.2 x 10(6) daltons. For small donor molecules (1 x 10(5) to 6 x 10(5) daltons per strand) the fraction intact increases with donor size from 10 to 50% of the total intracellular label, and the median strand length of this fraction is half that of the donor strands. By combining these results with earlier data on the size dependence of the yield of transformants per unit of total intracellular donor label, we have calculated the probability that a marker in the intact fraction will be integrated, as a function of the length of the donor strand after entry. This probability has a linear dependence on strand length for activities below 40% of maximum, and extrapolates to zero activity at 77,000 daltons per strand.


Irreversible adrenergic  -receptor antagonism by (R)-and (S)-N-(2-chloroethyl)-N-methyl-2-phenyl-2-hydroxyethylamine and related agents.


Regulation of the tyrosine biosynthetic enzymes in Salmonella typhimurium: analysis of the involvement of tyrosyl-transfer ribonucleic acid and tyrosyl-transfer ribonucleic acid synthetase. Mutants of Salmonella typhimurium were isolated that require tyrosine for growth because of an altered tyrosyl-transfer ribonucleic acid (tRNA) synthetase. Extracts of one strain (JK10) contain a labile enzyme with decreased ability to transfer tyrosine to tRNA(Tyr) and a higher K(m) for tyrosine than the wild-type enzyme. Strain JK10 maintains repressed levels of the tyrosine biosynthetic enzymes when the growth rate is restricted due to limitation of charged tRNA(Tyr). Several second-site revertants of strain JK10 exhibit temperature-sensitive growth due to partially repaired, heat-labile tyrosyl-tRNA synthetase. The tyrosine biosynthetic enzymes are not derepressed in thermosensitive strains grown at the restrictive temperature. A class of tyrosine regulatory mutants, designated tyrR, contains normal levels of tyrosyl-tRNA synthetase and tRNA(Tyr). These results suggest that charging of tRNA(Tyr) is not necessary for repression. This conclusion is substantiated by the finding that 4-aminophenylalanine, a tyrosine analogue which causes repression of the tyrosine biosynthetic enzymes, is not attached to tRNA(Tyr) in vivo, nor does it inhibit the attachment reaction in vitro. A combined regulatory effect due to the simultaneous presence of tyrS and tyrR mutations in the same strain was detected. The possibility of direct participation of tyrosyl-tRNA synthetase in tyrosine regulation is discussed.


Benzopyrones. 9. Synthesis and pharmacology of some novel bischromones.


Massive pulmonary embolism in the rat after alpha blocking.


A survey of professional activities of veterinary graduates in Victoria.


Castration of a stallion with bilateral abdominal cryptorchidism by flank laparotomy.


Dental caries and soil content of trace metals in two Colombian villages.


Determination of antibody to pneumococcal polysaccharides with chromic chloride-treated human red blood cells and indirect hemagglutination. A method is described for the quantitation of serum antibody to type-specific pneumococcal polysaccharide. The method uses highly purified pneumococcal polysaccharide coated onto human O+ red blood cells by the chromic chloride technique. Each of 14 pneumococcal polysaccharide types was individually coated onto red blood cells and used to determine the antibody response following primary immunization. The method was found to be sensitive, detecting antibody titer increases of several hundred to a thousand-fold. The presence of high preimmunization antibody titers did not obscure the detection of antibody titer increases. The method detected antibody of both the immunoglobulin M and immunoglobulin G class when quantitated after ultracentrifugation and sucrose density gradient separation. By using serum samples obtained from volunteers immunized with a single pneumococcal polysaccharide, the method was standardized resulting in an ability to compare samples taken at different times and obtained from different sources. The method appears to be simple, reproducible, and inexpensive and can be utilized to determine the antibody response following immunization in large population studies.


Are antibiotic drugs needed for the treatment of upper respiratory tract infections in infants? Much confusion exists about the necessity of using antibiotic drugs to treat upper respiratory tract infections in children, especially infants. In this study the frequency of bacterial causes of such infections was studied in 4746 children under three years of age. Clinical evidence of infection was absent in half of these children and present in the others. There was no practical difference between the frequency of positive cultures from infected and non-infected children, suggesting that antibiotics were not required.


An examination of some  -adrenoreceptor stimulants for selectivity using the isolated trachea and atria of the guinea pig.


A procedure for estimating sample size in clinical trials of dental caries preventives.


The mechanism of glutamate dehydrogenase reaction. IV. Evidence for random and rapid binding of substrate and coenzyme in the burst phase.


Primary structure of Escherichia coli glutamine synthetase. 3. Chemical evidence for subunit identity; amino acid sequences at the NH 2  and COOH termini.