Evidence for a centrally mediated hypotensive effect of L-dopa in the rat.


The use of a compression modulus to describe compaction behaviour.


The prediction of the tensile strength of tablets.


Medical terminology.

Medical terminology.


Biogenic amines in the developing brain.


Effects of cortisol and epinephrine on glial cells in culture.


Alterations related to the cerebral free amino acid pool during development.


Tissue cultures of blood-sucking arthropods and their use for the cultivation of viruses and rickettsiae.


Cations in component reactions of 'malic' enzyme catalysis. The ;malic' enzyme (EC 1.1.1.40) has been purified (300-fold) from wheat germ and its abilities to catalyse the decarboxylation and the hydrogenation of oxaloacetic acid and oxaloacetate esters was studied. The free 1-carboxyl group is essential for the interaction of oxaloacetates and substituted oxaloacetates with the enzyme via cations. The free 4-carboxyl group is required for the decarboxylation but is not indispensable for the hydrogenation. At high concentrations, cations inhibit the enzymic hydrogenation of oxaloacetic acid but not that of 4-ethyl oxaloacetate. A plausible inhibitory mechanism is proposed.


Effect of sulphate-limited growth on mitochondrial electron transfer and energy conservation between reduced nicotinamide-adenine dinucleotide and the cytochromes in Torulopsis utilis. 1. Conditions have been established for the sulphate-limited growth of Torulopsis utilis in continuous culture. 2. Mitochondria prepared from sulphate-limited cells lack both piericidin A sensitivity and the first energy-conservation site (site 1). Sensitivity to antimycin A or cyanide and the second and third energy-conservation sites were apparently unaffected by sulphate-limited growth. 3. Aerobic incubation for 8h of sulphate-limited cells with a low concentration of sulphate (50mum or less) resulted in the recovery of mitochondrial piericidin A sensitivity and site 1. The use of higher concentrations of sulphate (250mum or more) still resulted in the recovery of mitochondrial piericidin A sensitivity and site 1, but also resulted in the appearance of a non-phosphorylating oxidase, which mediated oxidation of the respiratory chain at about the level of cytochrome b in an antimycin A- and cyanide-insensitive manner. Both this alternative route and the conventional normal route of respiration were shown to coexist and to intercommunicate at the level of cytochrome b. 4. Low-temperature spectroscopy failed to identify any new respiratory component to explain the alternative route. 5. The apparent affinity of the alternative route for oxygen was similar to that for the conventional route through cytochrome oxidase, namely half-maximal activity at 0.1mum-oxygen or less. 6. The non-haem iron concentration of submitochondrial particles was unaffected by sulphate limitation, whereas the acid-labile sulphide concentration was lowered tenfold. Marked increases (between four- and 30-fold) in the acid-labile sulphide concentration of submitochondrial particles were observed in sulphate-limited cells after aerobic incubation with various concentrations of sulphate. The lowest increase (fourfold) was observed without added sulphate, the highest (30-fold) with 1.0mm added sulphate. 7. The ratio of non-haem iron to acid-labile sulphide in submitochondrial particles varied with different growth conditions from a maximum of 15.0 to a minimum of 0.72. It is suggested that analytical measurements of non-haem iron are an inadequate guide to the concentration of iron-sulphur protein in complex systems. 8. The effects of sulphate-limited growth on site 1 and piericidin sensitivity are interpreted to indicate a role for iron-sulphur protein in these properties. 9. The aerobic incubation of sulphate-limited cells with cycloheximide resulted in the recovery by mitochondria of site 1 but not of piericidin sensitivity. 10. The appearance of the alternative route for cyanide- and antimycin-A (but not piericidin A-) insensitive respiration on incubating sulphate-limited cells with sulphate concentrations higher than 250mum indicates that the alternative route involves an iron-sulphur protein.


Spectroscopic studies of flavoproteins and non-haem iron proteins of submitochondrial particles of Torulopsis utilis modified by iron- and sulphate-limited growth in continuous culture. 1. A spectroscopic resolution has been made of the components contributing to the ;iron-flavoprotein' trough extending from 450 to 520nm in the reduced-minus-oxidized difference spectrum of submitochondrial particles of Torulopsis utilis. 2. Seven components were identified other than cytochrome b, ubiquinone and succinate dehydrogenase. On the basis of the effects of iron- and sulphate-limited growth of cells on their subsequently derived electron-transport particles, and also by consideration of analytical measurements of the concentration of FMN, FAD, non-haem iron and acid-labile sulphide in the electron-transport particles in relation to the magnitude of the spectroscopic changes, it was possible to identify five of these components as follows: species 1a, the flavin of NADH dehydrogenase ferroflavoprotein; species 1b, the iron-sulphur component of NADH dehydrogenase ferroflavoprotein; species 1', the flavin of an NADPH dehydrogenase; species 2, an iron-sulphur or ferroflavoprotein component; species 3, the flavin of l-3-glycerophosphate dehydrogenase. Two additional components were a fluorescent flavoprotein, probably lipoamide dehydrogenase, and a b-type cytochrome reducible by NADH or NADPH but not reoxidizable by the respiratory chain. 3. Species 1b and 2 were undetectable in electron-transport particles from iron- or sulphate-limited cells, but could be recovered in vivo under non-growing conditions. 4. The recovery in vivo of species 2 but not species 1b was inhibited by cycloheximide. 5. The recovery of species 1b correlates with the recovery of site 1 conservation. 6. The recovery of species 1b with species 2 correlates with the recovery of piericidin A sensitivity. 7. Evidence is presented for an NADPH dehydrogenase distinct from NADH dehydrogenase. The oxidation of NADH and NADPH by the respiratory chain is sensitive to piericidin A, and an iron-sulphur protein common to both pathways (species 2) is suggested as the piericidin A-sensitive component. 8. The approximate E'(0) (pH7.0) values of species 1 (a and b, low potential) and species 2 (high potential) indicate that site 1 energy conservation occurs between the levels of species 1 (a and b) and species 2.


Affinity chromatography of dihydrofolate reductase. 1. Dihydrofolate reductase was purified from Lactobacillus casei MTX/R, and studied on affinity columns containing folic acid and methotrexate. Two forms of the enzyme were interconverted by incubation with substrates. 2. Affinity columns were prepared from agarose activated with cyanogen bromide and coupled with 1,6-diaminohexane. Stable folate derivatives were covalently attached by using a carbodi-imide condensation. 3. Columns containing folic acid retarded but did not retain the enzyme. 4. Methotrexate at pH 6.0 was particularly effective for retention of the enzyme. 5. There is selective loss of one form of the enzyme during affinity chromatography in the absence of added NADPH. This loss is due to conversion into a single enzyme form on the column. 6. NADPH has a dual effect in stabilizing the enzyme and in sensitizing it to inactivation by methotrexate, particularly in the presence of glycine. 7. Protein with affinity for methotrexate, but without dihydrofolate reductase activity, may also be eluted from the columns. 8. In a single-step procedure the enzyme was purified nearly 4000-fold from mammalian skin.


Enzymic and biochemical composition of smooth and rough microsomal membranes from monkey, guinea pig and mouse liver.


Some effects of 3-methylcholanthrene on uridine diphosphate glucuronyltransferase in the rat and guinea pig.


A comparison of some effects of dimethyl sulphoxide and dimethyl sulphone on rat liver microsomal enzymes.


Mitochondrial toxicity of ulcerogenic cinchophen and its derivatives in vitro.


Biochemical characteristics of insect microsomes. N- and O-demethylation.


Reduced nicotinamide-adenine dinucleotide phosphate (NADPH) enhancement of p-nitrophenol glucuronidation.


Physiological electron donor systems to the nitrogenase of the blue-green alga Anabaena cylindrica.


Action spectra of photosystem I and photosystem II in spinach chloroplast grana and stroma lamellae.


Spectrophotometric measurements of metabolic responses in isolated rat brain cortex.


Spectral changes in respiratory intermediates of brain cortex in response to depolarizing pulses.


Nucleo-cytoplasmic interactions in the acheivement of nuclear synchrony in DNA synthesis and mitosis in multinucleate cells.


Studies on the pathogenesis of multiple sclerosis. Basic proteins in the myelin and white matter of multiple sclerosis, subacute sclerosing panencephalitis and postvaccinal leucoencephalitis.


Periodontal reactivity to polymer implants containing cementum and dentin.


The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons.


Histochemical studies in infant Gunn rats with kernicterus.


Behavior and brain contents of catecholamines in mice during chronic administration of methyldopa.


Continuing education and the pediatric nurse associate.


The role of central monoamines in decapitation convulsions of mice.


The influence of sodium, potassium and calcium on spontaneous miniature potentials in frog sympathetic ganglion neurons.


Predicting rehospitalization from community placement.


Acceptance of trait-descriptive vs "medical model" oriented feedback statements.


Release of transmitters from storage: a contractile model.


Simple neuronal models to estimate turnover rate of noradrenergic transmitters in vivo.


The purification and properties of shikimate dehydrogenase.


Biochemistry of synaptic plasticity studied in single neurons.


The role and regulation of poly-beta-hydroxybutyrate synthesis in Azotobacter beijerinckii.


The physiological role of taurine.

The physiological role of taurine.


Trans-synaptic induction of dopamine (3,4-dihydroxyphenethylamine)  -hydroxylase in adrenergic tissues of the rat.


Scope of The National Foundation Conferences on Congenital Renal Dysfunction.


Localization of peroxidase and other microsomal enzymes in thyroid cells.


A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.


Peer supervision: a method of teaching.

Peer supervision: a method of teaching.


Themes in organizational life: the hospital.


Pointers for prospective authors.

Pointers for prospective authors.


A psychological view of nursing.

A psychological view of nursing.


Cyclophosphamide-induced graft-versus-host immunotolerance.


Synthesis and biological evaluation of substituted  -phenylcinnamonitriles. The synthesis of some new substituted alpha-phenylcinnamonitriles is reported.  Biological assay showed no bactericidal or fungicidal activity, no ability to depress the volume of gastric secretions, negative or marginal activity in fertility control, no antiparasitological activity and no agricultural activity.


Verbal response stereotypy as a function of psychological and physiological drive.


Decreased thermal stability of alcohol dehydrogenase in the presence of oxidized nicotinamide-adenine dinucleotide or oxidized nicotinamide-adenine dinucleotide phosphate.


The mechanism of ammonia assimilation in nitrogen fixing Bacteria.


In vitro metabolism of androgens in dog hypothalamus, pituitary, and limbic system.


Serum glutamic-oxaloacetic transaminase: evaluation of a coupled-reaction enzyme assay by means of kinetic theory.


Enzyme profile of the cytoplasmic droplet from bovine epididymal spermatozoa.


The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol.


Male fertility in patients treated for cryptorchidism before puberty.


Physiologic and pharmacologic studies of the human oviduct. Tubal motility during the menstrual cycle was measured in women by means of an indwelling polyvinyl catheter.  During all phases of the cycle, there were episodes of tubal motility at regular intervals.  These episodes were more frequent during menstruation but the intensity and duration were greater during the proliferative phase.  During the luteal phase the intensity and duration of the outburst were depressed.  The episodes of motor activity were asynchronous between the 2 tubes and between different portions of the same tube.  Activity in the rabbit was similar to that of the human and was found in the isthmic and ampullar portions of the tube but not in the infundibulum.  Intravenous administration of epinephrine or norepinephrine increased motility.  Alpha-adrenergic blockade with phentolamine mesylate and phenoxybenzamine suppressed spontaneous outbursts in the rabbit.  The tubes were sensitive to oxytocin but almost insensitive to vasopressin.  Suction of the breast increased tubal motility.


Diabetes mellitus with peripheral and autonomic neuropathy: case report of a child.


Right hepatic lobectomy.

Right hepatic lobectomy.


PKU program in Illinois. A 10 year study.


Treatment of penetrating wounds of the liver in Viet Nam.


HASP. Hospital Admission and Surveillance Program.


The eye and learning disabilities.

The eye and learning disabilities.


Illinois State Medical Society response to senate resolution No. 119, submitted October 20, 1971. Introduction.


D-Alanine: membrane acceptor ligase from Lactobacillus casei.


Studies on spinach ferredoxin-nicotinamide adenine dinucleotide phosphate reductase. Kinetic studies on the interactions of the reductase and ferredoxin and a possible regulation of enzyme activities by ionic strength.


Biosynthesis of a thouracil pheomelanin in embryonic pigment cells exposed to thouracil.


Presqualene alcohol. Further evidence on the structure of a C 30  precursor of squalene.


The regulation of tyrosine aminotransferase synthesis. Studies in HTC cells with inhibitors of ribonucleic acid synthesis.


Physical properties of glucose 6-phosphate dehydrogenase from Neurospora crassa.


Purification and partial characterization of glucose 6-phosphate dehydrogenase from Neurosopora crassa.


The pediatric nurse associate in a rural setting.


Some effects of genetic dissimilarity between mother and foetus.


The treatment of angina pectoris.

The treatment of angina pectoris.


Observations about the use of psychopharmaca in child psychiatry.


Impact of tumor grade and host resistance on survival of women with breast cancer.


Requirement for lymphocyte-macrophage interaction in the response of mouse spleen cultures to pneumococcal polysaccharide.


Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells.


Effects of breathing O 2  or O 2 +CO 2  and of the injection of neurohumors on the PO 2  of cat cerebral cortex.


A spectrophotometric method for the direct recording of dioldehydrase activity.


NADPH and ascorbate catalyzed peroxidation of microsomal lipids during ageing.


The induction of liver enzymes by cortisol after combined treatment of mice with X-irradiation and inhibitors of protein biosynthesis.


Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. I. Effects of glucocorticoids, N 6 ,O 2' -dibutyryl cyclic adenosine 3',5'-monophosphate and insulin in Reuber H35 cells.


Morphological aspects of exocytosin in the adrenal medulla.


The challenge to professional nursing.

The challenge to professional nursing.


Chromogranin A dopamine  -hydroxylase and secretion from the adrenal medulla.


Chromogranins in sympathetic nerves.

Chromogranins in sympathetic nerves.


Ultrastructural data on the cytology and cytochemistry of the autonomic nervous system.


The membrane of the chromaffin granule.

The membrane of the chromaffin granule.


Noradrenaline storage particles in splenic nerve.


Localization of neurophysin-II in the hypothalamo-neurohypophysial system of the pig by immunofluorescence histochemistry.


Immunochemical methods for demonstrating macromolecules in sympathetic neurons.


Release of neurophysin together with vasopressin by a Ca 2   dependent mechanism.


Synaptic vesicles in freeze-etched electric tissue of Torpedo.


Freeze-fracturing of presynaptic membranes in the central nervous system.


On the significance of cross-bridges between microtubules and synaptic vesicles.


Dynamic aspects of neurohormonal control of cyclic 3',5'-AMP synthesis in brain.


The actions of hormones on the adenyl cyclase system.


Phosphorylation of histones in vivo under the control of cyclic AMP and hormones.


Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1  with rat liver microsomes.


Circular dichroic titration of dihydrofolate reductase with TPNH.


Inhibition of mitochondrial nicotinamide nucleotide transhydrogenase by CoA-thioesters of long-chain fatty acids.


On the regulation of glutaminase in E. coli: metabolite control.


Prophylaxis of supraventricular tachycardia.


A comparative study of the repopulating potential of grafts from various haemopoietic sources: CFU repopulation.


A specific competitive antagonist of the vascular action of angiotensin. II.


Electrophoretic heterogeneity of bacterial nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenases. The specific activities of the nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase in crude cell-free extracts of 15 different microorganisms, grown aerobically in simple mineral salts media containing glucose as the sole carbon source, ranged from a maximum of 0.820 in Pseudomonas aeruginosa to a minimum of 0.145 in Thiobacillus novellus. Polyacrylamide gel electrophoresis indicated that the bacterial species studied contained electrophoretically distinct proteins exhibiting isocitrate dehydrogenase activity. The electrophoretic mobilities, as well as the differences in stability of the enzyme observed in this study, indicate that the physical and chemical properties of isocitrate dehydrogenase may differ widely between bacterial species.


The incidence of Candida albicans in hospital patients.


Adrenoreceptor classification.

Adrenoreceptor classification.


Acrylamide gel electrophoresis of intracellular proteins during early stages of sporulation in Bacillus subtilis. Acrylamide gel electrophoresis of unfractionated cellular extracts of Bacillus subtilis is shown to be an effective method for characterizing many of the changes in protein composition, when coupled with specific histological-type staining reactions. The results obtained here by using extracts from cells at different stages of growth and sporulation are consistent with observations from other laboratories where extensively purified and highly characterized enzymes have been studied. In several instances, the histochemical reactions can be associated with a specific enzymatic function and appear to indicate the presence of multiple molecular forms. In other instances, the data cannot be evaluated in terms of known enzyme function because the specificity of the histochemical analysis is not certain. However, the assays described permit monitoring of electrophoretic changes at the level of individual proteins within sporulating cultures. The results suggest that B. subtilis may contain two "hexokinase-like" enzymes which cease to function before sporulation is initiated. Aldolase and alanine dehydrogenase are detectable as single bands of enzyme activity during vegetative growth but as multiple molecular forms once sporulation has been initiated. Reduced nicotinamide adenine dinucleotide dehydrogenase activity is represented by an entire family of reactive species in these crude extracts, which undergo multiple changes during the early stages of sporulation. Tricarboxylic acid cycle dehydrogenase enzymes and those bands having esterase activity on alpha-naphthyl acetate show detectable changes in specific activity after cessation of exponential growth. Glucose dehydrogenase is not detectable until the sequence of changes leading to spore formation has progressed for 4 or 5 hr.


Conditioning recipients of hemopoietic cells with antilymphocytic serum (ALS) and partial-body irradiation.


Survey of adolescent drug use. I. Sex and grade distribution.


Additive effects of anesthetics and theories of anesthesia.


Regulation of the cytoplasmic inorganic pyrophosphatase of Rhodospirillum rubrum.


The metabolism of pyruvate by bovine-adrenal-cortex mitochondria.


Clinical signs of anesthesia.

Clinical signs of anesthesia.


Effects of adrenergic stimulation on ventilation in man.


Regional blood flow in acute dextran-exchange anemia.


Small intestinal injury in the immunologically runted mouse. Morphologic and autoradiographic studies.


Separation and spectrofluorometric assay of the  -adrenergic blocker sotalol from blood and urine.


Vasomotor and  -block negating actions of a hydroxamic acid.


Chemical respirogenesis. II. Reversal of postoperative hypoxemia with the "pharmacologic sigh".


Rapidly progressive glomerulonephritis.

Rapidly progressive glomerulonephritis.


Thymus-marrow cell interaction evaluated by PHA stimulation and graft versus host activity.


A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. The 78,000 x g microsomal fraction of canine ventricular myocardium effected a 20-fold concentration of [(3)H]norepinephrine from a 10(-9) M solution. The [(3)H]norepinephrine bound was displaced by physiologic concentrations of the beta-adrenergic catecholamines isoproterenol, epinephrine, and norepinephrine, in that order, which is the order of effectiveness of their actions on the force and rate of cardiac contraction. Alpha-adrenergic compounds did not displace [(3)H]norepinephrine until concentrations four orders of magnitude greater were reached. The beta-adrenergic blocker propranolol displaced at 10(-6) M, whereas the alpha-adrenergic blocker phentolamine was inactive. Metabolites of the catecholamines did not compete for this binding site. It is concluded that, on the basis of specificity and affinity of binding, these microsomal particles are likely to contain the beta-adrenergic receptor.


Effect of neostigmine on cardiac rhythm in digitalized dogs. Guest discussion.


The use of clomiphene citrate to assess pituitary gonadal function in males with delayed puberty.


DNA uptake during genetic transformation and the growing zone of the cell envelope. Continuous cellular incorporation of choline molecules is essential for DNA binding to competent pneumococci. The choline molecules are incorporated into the cell surface at the equatorial region of the cocci. As a working hypothesis, it is proposed that DNA molecules enter these bacteria at the growing zone(s) of the cell envelope.


Glycine-amide effect on the vasopressin stimulated sodium and water transport across toad bladder.


The influence of gonadal hormones on blood fatty acids and on retention of dietary linoleic acid by the immature female chick.


Temperature-induced changes in sodium transport and Na+-K+-adenosine triphosphatase activity in the intestine of goldfish (Carassius auratus L.).


Sexual differences in mitotic division rhythms.


Short period rhythms of liver glycogen content.


Professional liability insurance protection: an affirmative action program.


Role of carbonic anhydrase in lactate secretion by the swimbladder.


High-frequency pulsatile discharge of human sweat glands: myoepithelial mechanism.


Preparation of medical students for patient interviewing.


Tyrosine hydroxylase in bovine caudate nucleus.


Absorption, tissue distribution, and excretion of bunolol- 14 C by dogs.


Bunolol metabolism by dogs: isolation and identification of two acidic metabolites.


Bis-quaternary ammonium compounds: derivatives and congeners of bicyclo(2.2.2)octane.


Polycarboxylic acid ion-exchange resin adsorbates for taste coverage in chewable tablets.


Derivatives of 10,11-dihydro-5h-dibenzo(a,d)cycloheptene and related compounds. V. Homologous 4-azaketones and derivatives.


Synthesis of  14 C-labeled bunolol.

Synthesis of  14 C-labeled bunolol.


Lymphocyte trapping in tolerant mice.

Lymphocyte trapping in tolerant mice.


Leukocyte count in childhood pneumonia.

Leukocyte count in childhood pneumonia.


New enzyme electrode probes for D-amino acids and asparagine.


Alprenolol in resuscitation.

Alprenolol in resuscitation.


Drugs acting on the heart.

Drugs acting on the heart.


The evolution of the physician's assistant: Brownian movement or coordinated progress.


Interactions between glutamate dehydrogenase, transaminases, and keto acids.


Induction of hepatic tyrosine aminotransferase by indole amines.


Oral health status in the three London, Ontario, homes for the aged.


Restoration of norepinephrine responsiveness of solubilized myocardial adenylate cyclase by phosphatidylinositol.


Changes in testicular DNA produced in BALB-c mice by diethylstilbestrol.


Pepiatric nurse associate (practitioner).


Kidney enzyme changes in experimental proteinuria.


[36th meeting of the German Society for Circulation Research in Bad Nauheim on April 3-5, 1970].


The volution of corticosteroid function. The effects of corticosteroids on gluconeogenesis in poikilothermic vertebrates.


The processus vaginalis and gubernaculum. Their raison d'etre redefined.


An epidemiologic study of dental caries in race and geographic area.


The problem of hernia in infants and adolescents.


Corneal transplantation and histocompatibility.


Surgical treatment of corneal disorders.


Enhanced ventricular function after beta-blockade in hemorrhagic shock.


Cardiovascular effects of preparation CIBA 34,276-Ba and imipramine.


Is epinephrine reversal a phenomenon purely of  -adrenergic block?


A note on eye movements as a measure of emotional reactivity to chromatic elements in Rorschach stimuli.


Repression-sensitization and medical diagnosis.


The role of pharmacologically-active amines in resistance to Trichostrongylus colubriformis in the guinea-pig.


Tyrosine   ketoglutarate transaminase in the liver of rats with intra-uterine growth retardation.


The use of beta-adrenergic receptor blockade in the treatment of cardiac arrhythmias.


Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus. The injection of adrenergic and adrenolytic drugs directly into the brain through permanently implanted cannulas has yielded results showing that food consumption in the rat is regulated by a hypothalamic alpha-adrenergic "hunger" system. and a hypothalamic beta-adrenergic "satiety" system. The rats' differential responses to alpha-adrenergic and beta-adrenergic drugs injected into different hypothalamic sites indicate the following: (1) the lateral hypothalamic "feeding" center contains beta receptors, the activation of which produces satiation, presumably by inhibition of the lateral "feeding" cells; (2) the ventromedial hypothalamic "satiety" center contains alpha receptors, the activation of which produces eating, presumably by inhibition of the ventromedial "satiety" cells; and (3) the medio-lateral perifornical area of the hypothalamus contains both alpha and beta receptors, which lead to inhibition of the ventromedial or lateral hypothalamic centers respectively. It is suggested that the ventromedial and lateral hypothalamus are connected by reciprocal circuits, so that activation of the ventromedial center results in stimulation of the lateral beta receptors which inhibit the lateral "feeding" cells, and activation of the lateral center results in stimulation of the ventromedial alpha receptors which inhibit the ventromedial "satiety" cells.


Dopamine as a synaptic transmitter and modulator in sympathetic ganglia: a different mode of synaptic action. An analysis of the role of adrenergic transmission in mediating the hyperpolarizing, slow inhibitory postsynaptic potential has revealed that dopamine is apparently the specific synaptic transmitter for this response. An additional action of dopamine was discovered, namely the selective facilitation of another synaptic response, the slow excitatory postsynaptic potential. (This potential is a depolarizing response to the muscarinic action of acetylcholine.) This second, modulatory, role of dopamine has characteristics strikingly different from other known modes of synaptic action. After a brief initial action by dopamine, the facilitation of the slow excitatory postsynaptic potential response can persist for hours and is unaffected by a delayed blockade of the postsynaptic receptors for dopamine. This suggests that the modulation consists of a long-lasting metabolic and/or structural change induced in the postsynaptic neuron by dopamine. These conclusions are based on the demonstrated actions of dopamine and other catecholamines, as well as on effects (on dopamine actions and on slow postsynaptic potentials of alpha-adrenergic blockers, of blockade, of dopamine oxidase, of depletion of ganglionic catecholamine by muscarinic excitation, and of a selective re-uptake of dopamine after such depletion.


Five hundred sixteen ft. (16.6 ATA) five-day ocean saturation dive using a mobile habitat.


Feed digestibility and utilization by growing guinea pigs in helium-oxygen environments of ambient and 21 atmospheres absolute (ATA).


Influence of oxygen and carbon monoxide concentrations on blood carboxyhemoglobin saturation.


Antibody response of normal and germ free rats to injected sheep erythrocytes when held in a helium--oxygen atmosphere.


Human factors in relation to the development of pressurized cabins.


Case of mumps during hyperbaric exposure.


Physician's assistants.

Physician's assistants.


Intrinsic sympathomimetic activity in relation to the precipitation of heart failure by beta-adrenoceptive blockade.


Analysis of the effects of beta-adrenergic blockade on patterns and parameters of the respiratory--heart rate response.


Nursing dilemma.

Nursing dilemma.


Psychotherapy with the first Negro male on one southern university campus: a case study.


Relationship between patient-therapist compatibility and treatment effectiveness.


Utility of the mini-mult with delinquents.


Allied health personnel in the internist's office.


The physician's assistant: perpetuation of problematic patterns of delivering health care services.


Reduction in the incidence of cleft palate by phenobarbital in normal and chlorcyclizine-treated A-Jax mice.


Summary of seventh ANA Nursing Research Conference.


Assistance for the physician: nurse clinician or physician assistant.


Method for the detection of pyruvate kinase, aldolase, and other pyridine nucleotide linked enzyme activities after electrophoresis.


Experimental evidence for imipramine like activity of fenfluramine.


Action of glucagon on histamine-induced gastric acid secretion in dogs and rats.


Confidence limits of results of clinical caries tests with fluoride administration.


Hemodynamic effects of practolol at rest and during exercise.


The adrenergic receptors of the intraocular muscles in man. An in vitro study.


A histochemical study on the distribution of oxidative enzymes in retinal cultures.


Parasitological review. Plasmodium: the fine structure of malarial parasites.


Quantitative studies on the salivary flora. In a quantitative bacteriological study of the salivary flora from 50 children the following aerobic organisms were identified and enumerated: alpha-haemolytic streptococci, beta-haemolytic streptococci, Streptococcus faecalis, pneumococci, Staphylococcus aureus, Staph. albus and Staph. citreus, Neisseria spp, N. meningitidis, corynebacteria, aerobic lactobacilli, B. subtilis, H. influenzae, coliform organisms, and Candida spp. Many of the known potentially pathogenic members were present in large numbers. It is suggested that knowledge of the relative numbers of the organisms that comprise the salivary flora will lead to a greater understanding of the ecology of the mouth and of the pathogenesis of oral infections.


Model of psychological functioning.

Model of psychological functioning.


Drug metabolism by an acetone powder from rat hepatic microsomes.


Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells. 1. Neurones in the supraoptic nucleus were examined for their responsiveness to microiontophoretically applied monoamines and cholinomimetic agents. One hundred and sixty-one of the 749 neurones recorded were antidromically identified as neurosecretory cells.2. The monoamines, dopamine, noradrenaline and serotonin, reduced the activity of all cells which responded.3. Reduction in activity following noradrenaline administration was antagonized by the beta-adrenergic blocking agent MJ-1999 and potentiated by desmethylimipramine.4. Acetylcholine produced either a decrease or an increase in activity of responsive cells with depression the predominant result. Both the depressant and the excitatory response to acetylcholine were seen in individual neurosecretory cells which were depressed by noradrenaline.5. Application of acetyl-beta-methylcholine and carbaminoylcholine consistently resulted in depression of all responsive cells, while nicotine excited the majority of responsive cells. Both types of response were observed on the same neurosecretory cell.6. The depressant response was antagonized by the muscarinic blocking agent atropine while the excitatory response was antagonized by the nicotinic blocking agent dihydro-beta-erythroidine. Responses to acetylcholine were potentiated by the acetylcholinesterase inhibitor physostigmine.7. The data indicate that noradrenaline-containing terminals on these neurosecretory cells are likely to inhibit their discharge rate, while the presumed cholinergic terminals might function as either excitatory or inhibitory, depending on the receptor activated.8. These results support the hypothesis that ADH release is related to the neuronal activity of the supraoptic neurosecretory cell.


The regulation of 4 forms of tyrosine aminotransferase in adult and developing rat liver.


Preliminary report. L-phase organisms in maxillary sinus secretions.


The aetiology of acute otitis media in children. Occurrence of bacteria, L forms of bacteria and mycoplasma in the middle ear exudate. Relationship between bacterial findings in the middle ear exudate, nasopharynx and throat.


Plasma volume changes with long-term beta-adrenergic blockade.


Relationship between ribonucleic acid synthesis and the mechanism of enzyme induction in mammalian liver.


Allosteric binding of coenzymes to alcohol dehydrogenase.


The purification and properties of the respiratory-chain reduced nicotinamide--adenine dinucleotide dehydrogenase of Torulopsis utilis. 1. An NADH-ferricyanide reductase activity has been isolated from the respiratory chain of Torulopsis utilis by using detergents. The isolated enzyme contains non-haem iron, acid-labile sulphide and FMN in the molar proportions 27.5:28.4:1. The preparation is free of FAD and largely free of cytochrome. 2. The enzyme catalyses ferricyanide reduction by NADPH at about 1% of the rate with NADH, and reacts poorly with acceptors other than ferricyanide. The rates of reduction of some acceptors are, as percentages of the rate with ferricyanide: menadione, 0.35%; lipoate, 0.01%; cytochrome c, 0.065%; dichlorophenolindophenol, 0.35%; ubiquinone-1, 0.08%. 3. Several properties of submitochondrial particles of T. utilis (non-haem iron, acid-labile sulphide, FMN and an NADH-reducible electron-paramagnetic-resonance signal) were found to co-purify with the NADH-ferricyanide reductase activity. Thus about 70% of the FMN and, within the limits of accuracy of the experiments, 100% of the non-haem iron and acid-labile sulphide of submitochondrial particles derived from T. utilis cells grown under conditions of glycerol limitation (but relatively low iron availability) can be attributed to the NADH-ferricyanide reductase. 4. It was also shown that the component of submitochondrial particles specifically bleached at 460nm by NADH [species 1 of Ragan & Garland (1971)] co-purifies with the NADH-ferricyanide reductase. 5. This successful purification of an NADH dehydrogenase from T. utilis forms a starting point for investigating the molecular properties of phenotypically modified mitochondrial NADH oxidation pathways that lack energy conservation between NADH and the cytochromes.


Characteristics of the immunocompetent cells in the mouse thymus: cell population changes during cortisone-induced atrophy and subsequent regeneration.


Aspects of anaesthesia for middle ear surgery an blood loss during stapedectomy.


Intraocular pressure and retinal responses of dogs at 45,000 and 80,000 feet.


The Cambridge-Council concept or two nurse practitioners make good.


Early morning seminars that nurses hate to miss.


The role of uterine inflammation in the inhibition of decidualization by intraluminal antihistamines.


Tyrosine hydroxylase in neuroblastoma.

Tyrosine hydroxylase in neuroblastoma.


Glucose metabolism by the cryptorchid rat testis.


White House Conference on Aging, Washington, D.C.--November 28-December 2, 1971. Thoughts and afterthoughts.


Synthesis of new alkylamino- and alkylaminomethyl-5,8-quinolinequinones as inhibitors of coenzyme Q and as antimalarials.


Studies on cardiovascular drugs. 5. 1-Amino-3-phenoxy-2-propanol derivatives as  -adrenergic blocking agents.


-Adrenergic blocking agents. 11. Heterocyclic analogs of pronethalol (2-isopropylamino-1-(2-naphthyl)ethanol).


The distribution of the systemic connective tissue diseases, ulcerative colitis and Crohn's disease in New Zealand: an analysis of hospital admission statistics.


Redox and phosphorylation states and metabolite concentrations in frozen clamped livers of rats fed diets containing 1,3-butanediol and DL-carnitine.


Oxprenolol in Parkinson's disease.

Oxprenolol in Parkinson's disease.


The feldsher in the USSR.

The feldsher in the USSR.


Changes in ovarian venous blood flow following cannulation; effects of luteinizing hormone (LH) and antihistamine.


Multiple differentiated functions in an unusual clonal strain of hepatoma cells.


Further studies on the purification and physiological actions of sea nettle toxin.


Relationship of sodium retention produced by catapres to changes in renal hemodynamics.


Effect of phenoxybenzamine on luteinizing hormone release in the female rat. To clarify the mode of action of phenoxybenzamine, an alpha adrenergic blocking agent, its effects upon plasma LH levels in ovariectomized rats and upon the ovulatory LH surge expected between 1400 and 1600, the critical period, on the day of  proestrus in normal rats were studied.  A single injection of phenoxybenzamine, 20 mg/kg, given at 1300 on the day of proestrus bokced ovulation (1 out of 7 ovulating), while plasma LH did not differ from controls between 1500 and 1600.  An additional injection of 20 iu HCG at 1500 prevented the ovulation block (83% ovulating).  A single phenoxybenzamine injection at 1700 failed to prevent ovulation (5 out of 7 ovulating).  The beta adrenergic blocking agents, propanolol and MJ 1999, did not affect ovulation.  Treatment with phenoxybenzamine for 2 days, 20mg/kg/day, for 8 days, 10mg/kg/day, were did not prevent the rise causing a reduction in blood flow through the ovary rather than acting as a neurogenic stimulus in the hypothalamus.


Relationship between microbodies and the endoplasmic reticulum in the liver of adult rats.


Rapid polarographic microdetermination of dissolved oxygen in water with flavin enzyme.


Ecologic studies of Venezuelan encephalitis virus in southeastern México. 3. Infection of mosquitoes.


Metabolism of acetoin in mammalian liver slices and extracts. Interconversion with butane-2,3-diol and biacetyl. 1. [(14)C]Acetoin was enzymically synthesized from [(14)C]pyruvate with a pyruvate decarboxylase preparation. Its optical activity was [alpha](20) (d)-78 degrees . 2. Large amounts (1000-fold higher than physiological concentrations) of acetoin were incubated with rat liver mince. Acetoin disappeared but very little (14)CO(2) was evolved. A compound accumulated, which was purified and identified as butane-2,3-diol. Chromatography on borate-impregnated paper indicated the presence of both the erythro and threo forms. 3. Liver extracts capable of interconverting biacetyl, acetoin and butane-2,3-diol were obtained. These interconversions were catalysed by two different enzymes: acetoin dehydrogenase (EC 1.1.1.5) and butane-2,3-diol dehydrogenase (EC 1.1.1.4), previously identified in bacteria. Both required NAD(+) or NADP(+) as cofactors and were different from alcohol dehydrogenase. The equilibrium in both cases favoured the more reduced compound. 4. The activity of butane-2,3-diol dehydrogenase was decreased by dialysis against EDTA: the addition of Co(2+), Cu(2+), Zn(2+) and other bivalent metal ions restored activity. 5. Biacetyl reductase was resolved into multiple forms by CM-Sephadex chromatography and electrophoresis.


A disulfide reductase in spores of Bacillus cereus T.


Immunochemical studies of mangle gum (Rhizophora mangle L).


Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects.


Fluorometric analysis of glycolytic intermediates and pyridine nucleotides in peripheral blood cells.


Perspective on the physician's assistant.


Physician's assistants and the law.

Physician's assistants and the law.


Modulation of glutamine synthetase adenylylation and deadenylylation is mediated by metabolic transformation of the P II -regulatory protein. Earlier studies showed that two protein components, P(I) and P(II), are concerned with the adenylylation and deadenylylation of Escherichia coli glutamine synthetase (EC 6.3.1.2). P(I) by itself catalyzes both adenylylation and deadenylylation, but its activity is modulated by the P(II)-protein and by glutamine, 2-oxoglutarate, ATP, and UTP, The P(II)-protein exists in two forms: one form, P(II)-AT, stimulates P(I)-catalyzed adenylylation activity in the absence of glutamine and makes this activity very sensitive to inhibition by 2-oxoglutarate; it does not affect deadenylylation activity. The other form, P(II)-DA, stimulates adenylylation only if glutamine is present, and also stimulates the deadenylylation activity of P(I), which is then dependent upon the presence of ATP and 2-oxoglutarate. Conversion of P(II)-AT to P(II)-DA requires the presence of UTP, ATP, and 2-oxoglutarate; it is catalyzed by an enzyme present in P(I) preparations. UTP may be directly involved in this conversion since P(II)-DA fractions reisolated by filtration through Sephadex G-100 contain small quantities of a bound uridine derivative that lacks the gamma-phosphoryl group of UTP. The activity of P(II)-DA, but not of P(II)-AT, is destroyed by treatment with snake-venom phosphodiesterase. ATP and 2-oxoglutarate apparently function as allosteric effectors for the conversion of P(II)-AT to P(I)-DA.


Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes. HYBRIDS FROM A CROSS OF RAT HEPATOMA CELLS WITH DIPLOID EPITHELIAL CELLS FROM RAT LIVER HAVE BEEN STUDIED WITH RESPECT TO KARYOTYPE AND EXPRESSION OF TWO FUNCTIONS LIMITED TO THE HEPATOMA PARENT: high level of the enzyme tyrosine aminotransferase (EC 2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase) and its inducibility with steroid hormones. The hybrids that contain the complete chromosomal complements from both parents show low enzyme activity and no inducibility. One hybrid clone, and all of its derivatives, which have lost 30-40% of the chromosomes initially present, show enzyme inducibility. Induction of tyrosine aminotransferase in the hepatoma and hybrid cells responds similarly to inhibition by cycloheximide and actinomycin D, and to steroid concentration. The enzymes from induced and noninduced hepatoma cells and from induced hybrid cells are similar in heat sensitivity and intracellular distribution; those from noninduced hybrid and diploid rat epithelial cells are different.


Three closely linked genetic systems relevant to transplantation. The concept that antigens of a major histocompatibility locus (HL-A), the mixed leukocyte reaction, and the rejection of a graft are expressions of the same genetic region has been generally accepted. WE HAVE PRESENTED EXPERIMENTS THAT CHALLENGE THE ABOVE CONCEPT AND SUGGEST THAT THE REJECTION TIME OF SKIN AND ORGAN TRANSPLANTS IS DEPENDENT ON IMMUNIZATION AGAINST THE PRODUCTS OF TWO, AND POSSIBLY THREE, SEPARATE, BUT CLOSELY LINKED, GENETIC SYSTEMS: HL-A, mixed leukocyte reaction (MLR-S), and hypersensitivity delayed reaction (HDR). The findings presented and discussed here suggest that the HL-A antigens are not the primary factors involved in the cell-mediated component of allotransplantation, and that these antigens and phenotypes of the mixed leukocyte reaction can only be used as a guide in predicting the survival of allografts that are obtained from unrelated donors.


Invitro formation of assimilatory reduced nicotinamide adenine dinucleotide phosphate: nitrate reductase from a Neurospora mutant and a component of molybdenum-enzymes. An active Neurospora-like assimilatory NADPH-nitrate reductase (EC 1.6.6.2), which can be formed in vitro by incubation of extracts of nitrate-induced Neurospora crassa mutant nit-1 with extracts of (a) certain other nonallelic nitrate reductase mutants, (b) uninduced wild type, or (c) xanthine oxidizing and liver aldehyde-oxidase systems was also formed by combination of the nit-1 extract with other acid-treated enzymes known to contain molybdenum. These molybdenum enzymes included (a) nitrogenase, or its molybdenum-iron protein, from Clostridium, Azotobacter, and soybeannodule bacteroids, (b) bovine liver sulfite oxidase, (c) respiratory formate-nitrate reductase from Escherichia coli, (d) NADH-nitrate reductase from foxtail grass (Setaria faberii), and (e) FADH(2)- and reduced methyl viologennitrate reductase preparations from certain Neurospora mutants. Several molybdenum-amino-acid complexes, as possible catalytic models of nitrogenase, were inactive (as were some previously tested 20 nonmolybdenum enzymes) in place of the acid-treated molybdenum-containing enzymes. The results imply the existence of a molybdenum-containing component shared by the known molybdenum-enzymes.


Psychomotor stimulant self administration as a function of dosage per injection in the rhesus monkey.


Bancroftian filariasis in two villages in Dinajpur District, East Pakistan. II. Entomological investigations.


Experimental vector and wildlife host ranges of buttonwillow virus in Kern County, California.


Acute pneumonia in tropical infections.

Acute pneumonia in tropical infections.


Ecologic studies of Venezuelan encephalitis virus in southeastern Mexico. 8. Correlations and conclusions.


La Crosse virus isolations from mosquitoes in Wisconsin, 1964-68.


Isoelectric focusing studies on dihydrofolic reductase.


Dihydrofolate reductase from filarial worms and schistosomes.


Kinetic studies of the reaction mechanism of dihydrofolate reductase.


Kinetic investigation of the reaction mechanism of dihydrofolate reductase from L1210 cells.


Antifolate resistance and the genetic control of dihydrofolate reductase activity.


Proton magnetic resonance studies of folate and folate antagonists.


Interfering effect of incubation in carbon dioxide on the identification of pneumococci by optochin discs. Incubation of pneumococci in a CO(2) environment decreases the zone sizes produced by optochin discs, with the result that pneumococcal-like organisms require further study.


Metabolic degradations of nitrofurans by rat liver homogenate.


A comparison of the effects of benzypyrene administration on some hepatic microsomal mixed-function oxidases of rats and mice.


Effect of antimalarial drugs on the efflux of K+ from Streptococcus pyogenes.


Effect of diethylnitrosamine on the respiratory and enzymic response of rat liver to corticosterone.


The isolation of nuclear membrane from a large-scale preparation of bovine liver nuclei.


Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs.


The effect of Ag-B locus compatibility and incompatibility on neuron survival in transplanted sensory ganglia in rats.


In vivo antibacterial activity of disodium -sulfobenzylpenicillin.


Legal responsibility for actions of physicians' assistants.


The effect of LB-46, a new beta adrenergic blocking agent, on pulse and blood pressure at rest and after exercise in healthy volunteers.


The oxidation-reduction potentials of parsley ferredoxin and its selenium-containing homolog.


Electron carriers of the noradrenaline storage vesicles from bovine splenic nerves.


NAD-NADP-dependent MDH activity during the metamorphosis of the mealworm, Tenebrio molitor linnaeus.


Energy-linked nicotinamide adenine dinucleotide transhydrogenase in membrane particles from Escherchia coli.


Concentrations and synthesis of the acid-soluble nucleotides in the liver of various species of vertebrates.


The effect of selective cardiac adrenergic beta-blockade on the hypotensive effect of hydrallazine.


Parkinsonism.

Parkinsonism.


Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.


Effects of beta-adrenoreceptor blockade and nitroglycerin on myocardial oxygenation.


Effect of thiazol-4-ylmethoxyamine, a new inhibition of histamine biosynthesis on brain histamine, monoamine levels and behavior.


Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. V. Use of erythrocytes to demonstrate enzyme-dependent production of a component with the properties of a free radical.


MMPI: comparison between patients with coronary heart disease and their spouses together with other demographic data. A preliminary report.


Ethanol and induction of microsomal drug-metabolizing enzymes in the rat.


Monoamine oxidase inhibition and the activity of other oxidative enzymes in the brains of mice fed cuprizone.


Aflatoxin inactivation. Chemical and biological properties of ammonia and methylamine treated cottonseed meal.


Nature of neutral phosphorus ester metabolites of phosphamidon formed in rats and liver microsomes.


New assay for tyrosine aminotransferase with the amino acid analyzer.


Circulatory responses to beta adrenergic blockade with alprenolol. Studies in patients with chronic heart disease.


An on-line differential converter, for obtaining the first derivative of absorption spectra.


The treatment of shock with beta adrenergic blockade.


Metabolism of the phenothiazine drug perazine by liver and lung microsomes from various species.


"Activation" of nitrofurazone in animal tissues.


Induction by phenobarbital of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) cytochrome c reductase in regenerating rat liver.


Amphetamine-tetrazolium reductase activity in brain.


Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.


Role of phospholipid in electron transfer in a reconstituted liver microsomal enzyme system containing cytochrome P-450.


Studies on cytochrome P-450 of rat kidney cortex microsomes.


A new spectral species associated with cytochrome P-450 in liver microsomes.


Studies of the stoichiometric relationships between the oxidation of drugs and the oxidation of reduced pyridine nucleotides by liver microsomal enzymes.


The inhibitory effect of metyrapone on cytochrome P-450-catalyzed mixed-function oxidation reactions as compared to the effect of carbon monoxide.


Stress and brain nicotinamide adenine dinucleotides in normal and hypophysectomized rats.


The kinetics of ethylmorphine activation of the NADPH-cytochrome P-450 reductase activity of hepatic microsomes from male and female rats.


Studies on drug metabolism in human liver.


The state of NADPH-NADP +  during mixed-function oxidation of hexobarbital in hemoglobin-free perfused rat liver.


Compartmentation in relation to metabolic control in liver.


Salicylate and enzymes.

Salicylate and enzymes.


Decreased distribution of oxotremorine to brain after pharmacological blockade of its peripheral acetylcholine-like effects.


The significance of differences in the potency of enantiomers of anti-acetylcholine drugs.


A method for the continuous recording of peripheral vascular conductance.


The self-association in aqueous solutions of morphine sulphate and some related salts.


The identification of tablets and capsules containing barbiturates by MATR infrared spectroscopy.


Flow properties of aluminium soap-hydrocarbon systems.


The inhibitory transmitter: GABA or its choline ester?


Nuclear magnetic resonance studies of interactions between cetomacrogol and phenol.


Maximal responses in guinea-pig isolated ileum preparations: influence of longitudinal and circular muscle.


Action of methysergide on fenfluramine-induced contractions of the saphenous vein.


Analysis of the supersensitivity to noradrenaline induced by amphetamine in the isolated vas deferens of the rat.


Storage life of prostaglandin E 2  in ethanol and saline.


The identification of blue triphenylmethane food dyes by thin-layer chromatography.


Potentiation of the responses of the vas deferens of the guinea-pig to transmural stimulation and to noradrenaline, by triethylcholine and tetraethylammonium.


Gas-liquid chromatographic estimation of paracetamol.


Acetylcholine-like action of atropine on the ciliary epithelium of the frog oesophagus during the warmer months.


The stereoselectivity of some anti-acetylcholine acetylenic compounds.


Metabolic oxidation on aliphatic basic nitrogen atoms and their  -carbon atoms--some unifying principles.


Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. The effects of potential neurohormones on the intracellular concentrations of adenosine 3':5'-cyclic monophosphate have been examined with three clonal lines of cultured glial tumors. In all cases, norepinephrine and isoproterenol produced striking elevations of the intracellular concentrations of the cyclic nucleotide. The response was mediated by a beta-adrenergic receptor. This effect is hypothesized to represent a molecular mechanism for neuronal-glial communication coupled to concurrent communication between neurons.


Changes in macromolecular synthesis associated with the induction of glutamine synthetase in embryonic retina. The hydrocortisone-mediated induction of glutamine synthetase in the neural retina of chicken embryo in vitro is correlated with enhanced incorporation into protein of [(14)C]aspartic acid, an amino acid abundant in this enzyme. In the induced retina labeled with [(14)C]aspartic acid, a peak of radioactivity was detected in the region of the polysomal profile corresponding to polysomes comprising 12-14 ribosomes. In retinas labeled with [(3)H]uridine, an increased amount of radioactivity was also detected in the same polysomal region of the hydrocortisone-induced retina. If we assume a monocistronic messenger RNA for retinal glutamine synthetase, this region corresponds to the estimated size of the polysomes necessary for the translation of this enzyme. The evidence presented demonstrates a correlation between these changes in incorporation and the induction of glutamine synthetase.


Changes in enzymes of carbohydrate metabolism in rat uterus during early pregnancy.


The effect of amethopterin on the immune response.


The amino acid composition and some properties of the NAD + -specific glutamate dehydrogenase from Neurospora crassa.


Adult dental health in fluoride and non-fluoride areas. 2. Caries experience in each tooth type.


Receptors as defined by their pharmacological properties. In: Molecular properties of drug receptors.


Adenyl cyclase as a component of the adrenergic receptor. In: Molecular properties of drug receptors.


Extinction or distinction?

Extinction or distinction?


Trends in legislation.

Trends in legislation.


Humoral mechanism of ulcer-resistance of the organism adapted to physical exercise.


Tryptophan availability as a control of hepatic pyridine nucleotide concentration in mice.


Conversion of agroclavine by mammalian cytochrome P-450.


Photosystem II activity of chloroplast fragments lacking P700.


Trypsin inhibition of photosystem II.

Trypsin inhibition of photosystem II.


Pathways of intracellular hydrogen transport in the Walker carcinosarcoma 256. I. The intramitochondrial electron transport and the translocation of reducing equivalents across the mitochondrial membrane.


Adult dental health in fluoride and non-fluoride areas. 1. Mean DMF values by age.


Photosynthetic phosphorylation in Chlamydomonas reinhardi. Effects of a mutation altering and ATP-synthesizing enzyme.


Freeze-fracture faces of inner and outer membranes of mitochondria.


Not quite MD, more than PA.

Not quite MD, more than PA.


The Nigerian medical auxiliary.

The Nigerian medical auxiliary.


The fate of  3 H-norepinephrine released from isolated atria and vas deferens: effect of field stimulation.


Interactions of bretylium and other drugs on guinea-pig atria: evidence for inhibition of neuronal monoamine oxidase by bretylium.


Influence of cocaine and desipramine on the contractile response of isolated rabbit pulmonary arteries and aortae to transmural stimulation.


Effect of morphine on the catecholamine content of midbrain nerve cell groups in rat and mouse.


Metabolism of a beta blocking drug, oxprenolol.


The effect of intrahypothalamically injected sympathomimetic amines on temperature regulation in the cat.


Immunobiology of mammalian reproduction.


Everyone wins at health ministers' conference.


Mechanism of prolongation of the R-R interval with electrical stimulation of the carotid sinus nerves in man.


Plasma calcium assay, with use of the jellyfish protein, aequorin, as a reagent.


Halothane hepatitis: a critical review.

Halothane hepatitis: a critical review.


The anesthetic management of pheochromocytoma effect of preoperative adrenergic blocking drugss.


Review of 22 training programs for physician's assistants 1969.


Often unrecognized factors in the etiology of asthma.


Postanesthetic administration of doxapram hydrochloride and/or oxygen at an altitude of 1 mile.


Personality factors in prison volunteers related to response in clinical drug trials.


Toxicological and pharmacological properties of sea pansy, Renilla mulleri.


Some biological properties of Pneumococcus type 37 and the chemistry of its capsular polysaccharide. Pneumococcus Type 37, like pneumococcus Type 3, is characterized by the production of large mucoid colonies on the surface of solid media and by its very large capsule. It differs from the highly virulent pneumococcus Type 3 in that it is only slightly virulent for mice and rats and is isolated infrequently from man. A study of the behavior of pneumococcus Type 37 in systems comparable to those used in the study of pneumococcus Type 3 and an examination of the chemical structure of the capsule of pneumococcus Type 37 are described. The capsular polysaccharide of pneumococcus Type 37 is a viscous, optically inactive polymer composed of 95% hexose. Glucose is obtained in 88% yield upon acid hydrolysis. Periodate oxidation studies and the behavior of the polysaccharide on acid hydrolysis suggest that the molecule consists of a core of repeating units of 1,3 glucosyl-glucose to which short chains of glucose are attached at frequent intervals. Isolation of a disaccharide, the properties of which are identical with those of sophorose (beta1 --> 2 glucosyl-glucose), and of a trisaccharide are described. A tentative structure for the capsular polysaccharide of pneumococcus Type 37 is proposed.


Solution conformations of antihistamines.


Antagonism of norepinephrine responses of isolated rabbit aorta by aliphatic sulfur-containing amines.


The Second World Conference  on Smoking and Health. London, England, September 1971.


Biological disposition of tetrahydrocannabinols.


The tabby syndrome in the mouse.

The tabby syndrome in the mouse.


The complete dependence of beta-adrenergic drinking on the renal dipsogen.


Data on the neurohumoral organization of vasomotor reflex mechanisms.


Standards of performance in expanded practice.


The physiology of carbon monoxide production by deep-sea coelenterates: causes and consequences.


Establishment of "threshold" CO exposure levels.


Effects of sleep deprivation on the periodicity of tyrosine metabolism in mice.


The interaction of a fluorescent probe with rat hepatic microsomes.


Left ventricular approach for the repair of ventricular septal perforation and infarctectomy.


Kaiser health care.

Kaiser health care.


Impact of water fluoridation on dental practice and dental manpower.


Utilization of corpsmen in the occupational health setting.


The physician's associate in occupational medicine.


The nurse's role in meeting the challenges of medical care.


The crystallography of calf rennin (chymosin).


A note on the helical movement of micro-organisms.


Bone marrow grafts and histocompatibility.


Appearance of thrombogenic tendency induced by adrenaline and its prevention by  -adrenergic blocking agent, nialamide and pyridinolcarbamate.


The action of thyrotropin on thyroid metabolism.


Dopamine: spontaneous and drug-induced release from the caudate nucleus in the cat.


Biochemical alterations in the skeletal muscle of vitamin E deficient rats.


A comprehensive gas chromatographic scheme for the estimation of antiepileptic drugs.


Resistance of guinea pigs to leukemia following transfer of immunocompetent allogeneic lymphoid cells.


Alloxan diabetes in the pig (Sus domesticus). Response to glucose, tolbutamide and insulin administration.


In vitro lipogenesis in adipose tissue from alloxan-diabetic pigs (Sus domesticus).


The lipochrome pigment of molluscan neurons as a specific electron acceptor.


Influence of sex and reproductive condition on metabolic rates in the allegheny mountain salamander Desmognathus ochrophaeus.


The effect of different acclimation temperatures on gas secretion in the swimbladder of the bluegill sunfish, Lepomis macrochirus.


Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer.


The coagulation system of rhesus monkeys, Macaca mulatta.


Effect of face immersion on body temperature and tail blood flow in the rat.


Malabsorption in C57 mice experimentally infected with Johne's disease.


Selectively neutral mutations, transferrins and the evolution of natricine snakes.


Thermal acclimation and metabolism in the Allegheny Mountain salamander Desmognathus ochrophaeus.


Thermoregulatory responses of the peruvian penguin, Spheniscus humboldti.


Osmotic acclimation in the Red River pupfish, Cyprinodon rubrofluviatilis.


Oxygen consumption and water turnover of the fat-tailed marsupials Dasycercus cristicauda and Sminthopsis crassicaudata.


Forebrain activation of single units in preoptic area of sunfish.


Methemoglobin in erythrocytes of rainbow trout.


Evidende for an effect of sodium pumping on spontaneous contractility of rabbit detrusor muscle.


Somatic and gametic dry matter and protein in gravid females of several amphibian species.


Developmental physiology of cestodes. X. The effects of crowding on carbohydrate levels and on RNA, DNA and protein synthesis in Hymenolepis diminuta.


Oxygen consumption and water metabolism in a carnivorous mouse.


Fluctuations in the preoptic-anterior hypothalamic temperature in the bat, Eptesicus fuscus.


Creatine in diving animals--a comparative study.


On the mechanisms of water absorption in the rat colon.


Heat balance during preoptic heating and cooling in the ground squirrel, Citellus tridecemlineatus.


Temperature acclimation in the nervous system of the brown bullhead (Ictalurus nebulosus).


Respiratory response of the teleost Poecilia reticulata to rising temperature.


Immunodiffusion--a technique for coelenterate polyp identification.


Four cases of periarteritis nodosa associated with persistant Australia antigen.


Some new vascular and biochemical aspects of the mechanism of action of ergot compounds.


A multiple-examiner clinical evaluation of a sodium fluoride dentifrice.


Studies on P-450. 8. Effects of steroids on the reaction with oxygen and the rate of reduction of partially purified P-450 from adrenocortical mitochondria.


Substrate induced dimerization of D-amino-acid oxidase.


Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors. Interactions between human platelets and several common species of bacteria have been studied in vitro by the technic of recording nephelometry. Results of this investigation have established the following parameters of platelet-bacterial interaction: (1) Bacteria are potent stimuli of the platelet-aggregating reaction. (2) The platelet-bacterial interaction proceeds through four distinct phases which are separable by varying the platelet-bacterial ratios or adding appropriate chemical inhibitors. (3) The degree and rate of the platelet response is proportional to the ratio of bacteria to platelets. (4) Direct contact between platelets and bacteria, physiologic levels of divalent cations and nucleotide release from platelets are essential for aggregation of platelets by bacteria. (5) By adding equivalent numbers of six species of microorganisms to platelet-rich plasma, their potency as initiators of the platelet reaction was determined, with Staphylococcus being the most powerful.


Tachycardia in thyrotoxicosis.

Tachycardia in thyrotoxicosis.


Alpha-adrenergic blockade in treatment of heart failure.


Differential responses of glucose 6-phosphate dehydrogenase and lipogenesis to fat-free diets.


Resistance to beta-adrenoceptor stimulants.


Screening for mental disorder.

Screening for mental disorder.


Personality subtypes of male and female alcoholic patients.


Chemical and enzymatic composition of microsomal subfractions from rat liver after treatment with phenobarbital and 3-methylcholanthrene.


Codeine and glutethimide addiction.

Codeine and glutethimide addiction.


The effect of phloxin on bethanechol and histamine stimulated gastric acid secretion in rats.


Studies on the glutathione stability of normal and glucose-6-phospate-dehydrogenase-deficient human erythrocytes.


L-leucine: a neuroactive substance in insects. A compound was isolated from the blood of silkworm larvae, Bombyx mori, which had been prostrated with DDT; this compound increased the spontaneous discharge in the isolated abdominal nerve cord of the American cockroach, Periplaneta americana. The compound was identified as L-leucine.


Bone marrow transplantation in man.

Bone marrow transplantation in man.


Experimental aspects of bone marrow transplantation in primates.


Allogeneic marrow transplants in cyclophosphamide treated mice.


Screening of African Strychnos species for convulsant and muscle-relaxant effects.


Thymus: an essential factor in lymphoid repopulation.


Hemolysis of erythrocytes by primary pharmacologic agents.


Dihydrofolate reductases: structural and mechanistic aspects.


-Oxidation of fatty acids. II. Enzymatic oxido-reduction of 17-hydroxystearic acid.


Control of glutamine synthesis in rat liver. 1. On perfusion of livers from fed rats with a semi-synthetic medium containing no added amino acids there is a rapid release of glutamine during the first 15min (15.6+/-0.8mumol/h per g wet wt.; mean+/-s.e.m. of 35 experiments), followed by a low linear rate of production (3.6+/-0.3mumol/h per g wet wt.; mean+/-s.e.m. of three experiments). The rapid initial release can be accounted for as wash-out of preexisting intracellular glutamine. 2. Addition of readily permeating substrates, or substrate combinations, giving rise to intracellular glutamate or ammonia, or both, did not appreciably increase the rate of glutamine production over the endogenous rate. The maximum rate obtained was from proline plus alanine; even then the rate represented less than one-fortieth of the capacity of glutamine synthetase measured in vitro. 3. Complete inhibition of respiration in the perfusions [no erythrocytes in the medium; 1mm-cyanide; N(2)+CO(2) (95:5) in the gas phase] or perfusion with glutamine synthetase inhibitors [l-methionine dl-sulphoximine; dl-(+)-allo-delta-hydroxylysine] abolishes the low linear rate of glutamine synthesis, but not the initial rapid release of glutamine. 4. In livers from 48h-starved rats initial release (0-15min) of glutamine was decreased (10.6+/-1.1mumol/h per g wet wt.; mean+/-s.e.m. of 11 experiments) and the subsequent rate of glutamine production was lower than in livers from fed rats. Again proline plus alanine was the only substrate combination giving an increase significantly above the endogenous rate. 5. The rate of glutamine synthesis de novo by the liver is apparently unrelated to the tissue content of glutamate or ammonia. 6. The blood glutamine concentration is increased by 50% within 1h of elimination of the liver from the circulation of rats in vivo. 7. There is an output of glutamine by the brain under normal conditions; the mean arterio-venous difference for six rats was 0.023mumol/ml. 8. The high potential activity of liver glutamine synthetase appears to be inhibited by some unknown mechanism: the function of the liver under normal conditions is probably the disposal of glutamine produced by extrahepatic tissues.


Oxidation of reduced nicotinamide nucleotides by diamide (NNN'N'-tetramethylazoformamide).


Regulation of tyrosine- -ketoglutarate transaminase in rat liver.


Solubilization and purification of trans-farnesyl pyrophosphate-squalene synthetase.


The effects of reduced nicotinamide adenine dinucleotide phosphate, its structural analogues, and coenzyme A and its derivatives on the rate of dissociation, conformation, and enzyme activity of the pigeon liver fatty acid synthetase complex.


Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver.


Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450.


The recovery of spermatogenesis in the rat testis after heat-induced degeneration.


Platelet transfusion therapy.

Platelet transfusion therapy.


Two years' experience with cadaveric renal transplantation.


Poisoning from delayed release tablets.

Poisoning from delayed release tablets.


Interactions of substrate and non-substrate effectors with p-hydroxybenzoate hydroxylase from pseudomonas fluorescens.


Efflux of amino acid neurotransmitters from rat spinal cord slices. I. Factors influencing the sponatenous efflux of ( 14 C)glycine and  3 H-GABA.


The pharmacology of recurrent inhibition in the supraoptic neurosecretory system.


Glucose production and glucose-6-phosphatase activity in rabbit retina.


An electrophysiological study of auditory masking of clicks in goldfish.


Efflux of amino acid neurotransmitters from rat spinal cord slices. II. Factors influencing the electrically induced efflux of ( 14 C)glycine and  3 H-GABA.


Effects of temperature and feeding on intermediary metabolism in North American eels (Anguilla rostrata LeSueur).


Effects of a high protein, "carbohydrate-free" diet on liver and kidney constituents and kidney function in chicks.


The water economy of Israel amphibians: the urodeles triturus vittatus (Jenyns) and Salamandra salamandra (L.).


The contribution of absorbed linoleic acid to the metabolism of the mature laying hen.


The absence of brown adipose tissue in birds.


The effect of temperature on the oxygenation of gopher snake blood.


Thermoregulation in the northern elephant seal, Mirounga angustirostris.


Electrocardiographic observations on the tuatara, Sphenodon punctatus.


On the water economy of Israel amphibians; the anurans.


Persistent rhythms of locomotion activity in the turtle Pseudemys scripta.


A re-evaluation of the anaerobic endproducts of fresh-water fish exposed to environmental hypoxia.


Comparative study on some amylases in mammalian blood serum.


Septal olfactory organ in Peromyscus.

Septal olfactory organ in Peromyscus.


Seasonal changes in lemming pituitary-adrenal response to cold exposure.


In vitro uptake of tritiated glucose, tyrosine and leucine by adult Alaria marcianae (La Rue) (trematoda).


Excretion of urea by two teleosts exposed to different concentrations of ambient ammonia.


The cholinergic nature of the cercal nerve-giant fiber synapse in the sixth abdominal ganglion of the American cockroach, Periplaneta americana (L.).


Screening for neurotransmitters: a rapid radiochemical procedure.


Influence of lanthanum on transmitter release at the neuromuscular junction.


Effect of metabolic inhibitors upon virus-induced inhibition of host cell macromolecular synthesis.


Serological of feces.

Serological of feces.


Alcaligenes odorans, varietas viridans.

Alcaligenes odorans, varietas viridans.


Prophylactic effect of clofazimine in murine tuberculosis.


Isolation and study of antigenic mutants of saprophytic and pathogenic Leptospiras.


Use of physicians' assistants in the delivery of medical care.


Intraleukocytic microbicidal defects.

Intraleukocytic microbicidal defects.


Enzymatic studies on the oxidative cyclizations of squalene.


The effect of the administration of N,N-dimethyl-4-aminoazobenzene (DAB) on the activity of DAB-reductase and NADPH-cytochrome c reductase.


Hepatic glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase levels in Japanese quail following the ingestion of p,p -DDT and related compounds.


Diminished biological activity of C 21 -steroids in rats pretreated with a thiouracil derivative. Stimulation of steroid hydroxylation?


Increased activity of liver tyrosine-alfa-ketoglutarate transaminase in rats subjected to trauma.


3-Hydroxylation of coumarin or 4-methylcoumarin by rat-liver microsomes and its induction by 4-methylcoumarin given orally.


The quantitative assessment of the therapeutic effect of methamphetamine on psychiatric patients.


Synthesis of 1-p-chlorobenzyl-7-azaindole-3- -piperidylmethanol as a potential antimalarial agent.


-Adrenergic blocking agents of the chromone and xanthone groups.


Synthesis of trimethoprim variations. Replacement of CH 2  by polar groupings.


Changes in glutamic acid and glutamine metabolism in the rat brain after whole body X-irradiation.


The effect of bicuculline, metrazol, picrotoxin and strychnine on the release of ( 3 H)GABA from rat brain slices.


Homotransplantation of the canine larynx.


Pulmonary dirofilariasis--a case in Western Australia.


Release of ( 3 H)noradrenaline and ( 3 H)dopamine from field stimulated cerebral cortex slices. Effect of tyrosine hydroxylase and dopamine- -hydroxylase inhibition.


The influence of pregnenolone-16 -carbonitrile on hepatic mixed-function oxygenases.


Effects of adenosine-3',5'-monophosphate on steroidogenesis and glycolysis in the rat adrenal gland incubated in vitro.


Suppression of graft-versus-host reaction by cis-platinum. II. Diaminodichloride.


The conditioning of the recipient as a factor enhancing immune insufficiency induced by the graft-versus-host reaction.


Uncoupling of oxygen activation from hydroxylation in the steroid C-21 hydroxylase of bovine adrenocortical microsomes.


Treatment of arrhythmias with pindolol.

Treatment of arrhythmias with pindolol.


Effects of phenazine methosulfate on glucose metabolism in rat adipose tissue.


Significance of the steroid-induced type I spectral change in steroid C-21 hydroxylase system of bovine adrenocortical microsomes.


Metabolism of human erythrocyte glucose-6-phosphate dehydrogenase. VI. Interconversion of multiple molecular forms.


Evidence for a tyrosine residue at the triphosphopyridine nucleotide-binding site of 6-phosphogluconate dehydrogenase.


Ganglionic blockade by rhazidine.

Ganglionic blockade by rhazidine.


Fine structure of the spermatozoon of Tubularia larynx (Hydrozoa, Coelenterata).


Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1  hybrid rats.


Peroxidative oxidation of methanol in human liver: the role of hepatic microbody and soluble oxidases.


Effect of decarboxylase inhibition and neuroleptic drugs on the DOPA level in rat brain.


Protection by glucocorticoids against ganglioplegics.


Inhibition of 7- 14 C-nicotinic acid metabolism in the human blood platelet by anti-inflammatory drugs.


Treatment of pregnancy toxaemia with alpha-blocking agents.


Neurohumoral mechanisms in the brain slice.


Disodium cromoglycate. Mode of action and its possible relevance to the clinical use of the drug.


Effects on cardiac muscle of the  -adrenoceptor blocking drugs INPEA and LB46 in relation to their local anaesthetic action on nerve. 1. As a local anaesthetic on frog nerve, LB46 had 0.4 times the activity of procaine and 2 times that of INPEA.2. In reducing the maximum rate of depolarization (MRD) of intracellularly recorded cardiac action potentials, LB46 was 20 times more potent than INPEA.3. As an antagonist of the chronotropic effect on atrial muscle and of the inotropic effects on ventricular muscle of isoprenaline the pA(2) values for LB46 were 9.05+/-0.15 and 9.30+/-0.06 respectively, and for INPEA 6.00+/-0.16 and 6.10+/-0.12.4. LB46 was 8 times more active than racemic propranolol in blocking the effects of isoprenaline on isolated cardiac muscle, and since its direct action on the cardiac membrane was only 0.1 times that of propranolol, there was a net gain of 80 times in the specificity of LB46 for class 2 (antisympathetic) over class 1 (depression of MRD) antidysrhythmic actions.5. INPEA was 2.5 times less active as a beta-adrenoceptor blocking drug on cardiac muscle than (+)-propranolol, and 1,300 times less active than LB46.6. INPEA, but not LB46, prolonged the duration of both atrial and ventricular intracellular action potentials.


Glutamine antagonists in chemotherapy.

Glutamine antagonists in chemotherapy.


Blockade by phenoxybenzamine of the contractor response produced by agonists in the isolated ileum of the guinea-pig. 1. The effects of various concentrations of phenoxybenzamine (dibenzyline) on the contractor response of the isolated ileum of the guinea-pig were investigated. The agonists tested were histamine, 5-hydroxytryptamine (5-HT), acetycholine and potassium chloride.2. In addition, uptake of (14)C-phenoxybenzamine into the ileum was determined as a function of antagonist concentration. The uptake increases sharply at concentrations above 10(-6) g/ml, (3x10(-6)M) and was not saturable at any concentration tested.3. In the presence of low concentrations of phenoxybenzamine, the dose-response curve for histamine undergoes a parallel shift of about 0.5 log units. At higher concentrations of phenoxybenzamine the maximum response is depressed. In the case of the other agonists, the maximum response is depressed as soon as any blockade becomes apparent.4. The ease of blockade with phenoxybenzamine is 5-HT >/= histamine>> acetylcholine >/= potassium chloride.5. These results do not lend support to the ;spare-receptor' hypothesis and may be better explained by the ;two-site' hypothesis of Moran & Triggle (1970).6. It may further be concluded that the successful antagonism of potassium-induced contractions in this preparation lies in the ability of phenoxybenzamine to prevent the action of released acetylcholine. In the case of the contraction induced by 5-HT, phenoxybenzamine probably interferes with the 5-HT receptor responsible for neuronal release of acetycholine.


Bretylium potentiation of the contractor responses of isolated rabbit aortic strips to potassium and tyramine. 1. Pretreatment of rabbit aortic strips with bretylium potentiated the contractor response to potassium and tyramine but not to noradrenaline. On the other hand, such pretreatment inhibited the response to nicotine.2. Even in reserpinized or cold stored aortic strips, pretreatment with bretylium enhanced the contractor response to potassium and tyramine.3. Pretreatment of fresh, reserpinized, or cold stored aortic strips with pheniprazine potentiated the contractor response to potassium and tyramine.4. Pretreatment of aortic strips with bretylium or pheniprazine did not potentiate the response to 5-hydroxytryptamine (5-HT).5. The results indicate that both bretylium and pheniprazine potentiate the action of tyramine and potassium, not by presynaptic mechanisms, but by postsynaptic action, causing an increase in the sensitivity of the effector cells to the stimulants.


Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. 1. 4-Hydroxypropranolol, a metabolite produced after oral administration of propranolol, has been shown to be a beta-adrenoceptor blocking drug. It is of similar potency to propranolol in antagonizing the effects of isoprenaline on heart rate and blood pressure in cats and against isoprenaline protection of guinea-pigs from bronchospasm. It is not cardioselective.2. In rats depleted of catecholamine 4-hydroxypropranolol produced an increase in heart rate, suggesting that it has intrinsic sympathomimetic activity.3. In anaesthetized dogs 4-hydroxypropranolol produced a decrease in heart rate and dP/dt and an increase in A-V conduction time at doses within the range 0.09-1.25 mg/kg. These effects are a result of beta-adrenoceptor blockade. In dogs depleted of catecholamines these same doses produced an increase in heart rate and dP/dt and a decrease in A-V conduction time. These responses were antagonized by propranolol, and were due to the intrinsic sympathomimetic activity of the compound. At higher doses (5.25 and 13.25 mg/kg) a further dose dependent decrease in heart rate and dP/dt and an increase in A-V conduction time occurred. This trend was also seen in animals depleted of catecholamines. These changes represent membrane stabilizing activity of 4-hydroxypropranolol.4. 4-Hydroxypropranolol is a potent beta-adrenoceptor blocking drug with both intrinsic sympathomimetic activity and membrane stabilizing activity.


Effect of chronic administration of nicotine on the concentrations of adrenal enzymes involved in the synthesis and metabolism of adrenaline. Chronic administration of nicotine caused an increase in tyrosine hydroxylase and catecholamine concentrations in rat adrenals, but failed to affect adrenal monoamine oxidase, catechol-O-methyl transferase or phenylethanol-amine N-methyl transferase activities.


Pyruvic acid metabolism and ethanol formation in Erwinia amylovora.


Cell culture as a test system for toxicity.


Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain.


Administration of two or more related drugs to investigate the effect of molecular modification and formulation on drug absorption, metabolism and excretion.


Some aspects of the metabolism of morphine-N-oxide.


The metabolism and binding of ( 14 C)mycophenolic acid in the rat.


Structural influences upon antihistamine activity; 3-amino-1-aryl-1-(2-pyridyl)propenes and related compounds.


Potential irreversible inhibitors of acetylcholinesterase: N-trimethyl-N-iodoacetyl diaminoalkane iodides.


The effects of substituting tetrazole for carboxyl in two series of anti-inflammatory phenoxyacetic acids.


Sulphamethoxydiazine crystal forms.

Sulphamethoxydiazine crystal forms.


Correlation of analgesic potencies of N-substitued normeperidines and in vitro N-dealkylation.


-Methyltryptophan increases 5-hydroxytryptamine-like material in rat brain.


A possible synaptic mechanism underlying the similar behavioural effects of adrenaline-like and acetylcholine-like drugs.


Failure of peristaltic stimulants to restore peristalsis previously blocked by 2,4-dinitrophenol.


Increased toxicity of morphine-like analgesics in aggregated mice.


The effect of pethidine on the 5-hydroxytryptamine and 5-hydroxyindoleacetic acid content of the mouse brain.


Comparison of four vehicles for intraperitoneal administration of  -tetrahydrocannabinol.


Changes in brain monoamine concentrations during the oestrous cycle in the mouse: possible pharmacological implications.


Relaxing potency of terbutaline and orciprenaline on rat uterus.


The centrally induced fall in blood pressure after the infusion of amphetamine and related drugs into the vertebral artery of the cat.


The effect of diethyldithiocarbamate on amphetamine-induced behaviour in rats.


Isoprenaline stimulates  -adrenoceptors in bovine pulmonary blood vessels.


A study of aqueous systems of purified non-ionic surfactant by membrane osmometry.


Further evidence on the question of polymorphism in aspirin.


The potential of bacterial photosynthesis in recycling of human wastes.


Catecholamines and the hydroxylation of tyrosine in synaptosomes isolated from rat brain. Tyrosine hydroxylase activity of synaptosomes isolated from rat brain was examined. A modified tritium-displacement assay was used, which allowed the measurement of tyrosine hydroxylase activity without the addition of either inhibitors of the metabolism of the hydroxylated products or added exogenous cofactor. The enzyme activity was strongly inhibited by the addition of exogenous catecholamines and 3,4-dihydroxy-L-phenyl-alanine. Aromatic amines other than catechols did not markedly influence tyrosine hydroxylase activity. These in vitro findings support the hypothesis that synthesis of catecholamines is regulated by a mechanism of end-product inhibition at the tyrosine hydroxylase step.


Effects of lanthanum ions on function and structure of frog neuromuscular junctions.


Mutant strains of Escherichia coli K12 that use D-amino acids. A series of mutations has been isolated that confer upon amino-acid auxotrophs of Escherichia coli K-12 the ability to grow when fed various D-amino acids. Several distinct systems, mediating cellular use of the D-isomers of leucine, histidine, phenylalanine, tyrosine, tryptophan, isoleucine, and valine, can be mutationally activated. Mutations leading to D-tryptophan use (dadR) all map near purB. They result in high activities of an enzyme that deaminates D-amino acids. Neither the enzymes of the tryptophan biosynthetic pathway nor tryptophanase (EC 4.2.1.e) are involved in D-tryptophan utilization.


The ontogeny of tooth succession in Lacerta vivipara Jacquin (1787).


Thyroid state: effects on pre- and postsynaptic central noradrenergic mechanisms. For hypothyroid rats, spontaneous motor activity was less than that in matched normal controls, and the specific activity of tyrosine hydroxylase in the midbrain was significantly greater than that in controls. Rats made hyperthyroid with thyroxine became hyperactive and showed increased sensitivity to the behaviorally activating effects of norepinephrine administered intraventricularly. In hyperthyroid rats, the specific activity of tyrosine hydroxylase in the midbrain remained within the normal range. These results are consonant with studies that suggested both receptor "tuning" and feedback regulation of activity of enzymes involved in biosynthesis of presynaptic neurotransmitter as methods of regulation of the central catecholamine synapse. These results may also help explain the reported potentiation by thyroid hormone of the antidepressant effects of imipramine.


Preliminary report on the distribution and epidemiology of filariasis in the Seychelles Islands, Indian Ocean.


Molecular aspects of drug metabolism.

Molecular aspects of drug metabolism.


A study of the mechanism of immunological unresponsiveness to skin allograft as induced by cell-free tissue extracts. I. Combination of alloantigens in cell-free and cellular forms.


Different sensitivity of H-2K and H-2D incompatibility to ALS immunosuppression.


Some changes in verbal reactions, attentions, intellectual work capacity and memory in elderly and old people physically trained in the course of two years.


Treatment of insect sting reactions.

Treatment of insect sting reactions.


Infection with Diplococcus pneumoniae and Salmonella typhimurium in monkeys: changes in plasma lipids and lipoproteins.


Medical assistants. The legal angle.

Medical assistants. The legal angle.


Long-term adaptation of weanling rats to high dietary levels of methionine and serine.


MMPI alcoholism scales. Factor structure and content analysis.


Differences in drug response of the sporogonous cycles of three strains of Plasmodium falciparum in Anopheles stephensi.


Effects of psychoactive drugs on sperm motility.


Blood histamine, polyamines and the schizophrenias. Computer correlations of the low and high blood histamine types.


Chemoprophylaxis of experimental post ischemic edema of the rat paw.


The significance of diagnosis in the treatment of narcotics addicts.


Phenobarbital-induced changes in NADPH-cytochrome c reductase and smooth endoplasmic reticulum in human liver.


Synthesis of NADP-dependent triosephosphate dehydrogenase independent of illumination in Chlorella variegata.


The emerging physician's assistant.

The emerging physician's assistant.


Photosynthetic carbon metabolism.

Photosynthetic carbon metabolism.


The Utah MEDEX demonstration project.

The Utah MEDEX demonstration project.


The light reactions of photosynthesis.

The light reactions of photosynthesis. Historically, the role of light in photosynthesis has been ascribed either to a photolysis of carbon dioxide or to a photolysis of water and a resultant rearrangement of constituent atoms into molecules of oxygen and glucose (or formaldehyde). The discovery of photophosphorylation demonstrated that photosynthesis includes a light-induced phosphorus metabolism that precedes, and is independent from, a photolysis of water or CO(2). ATP formation could best be accounted for not by a photolytic disruption of the covalent bonds in CO(2) or water but by the operation of a light-induced electron flow that results in a release of free energy which is trapped in the pyrophosphate bonds of ATP. Photophosphorylation is now divided into (a) a non-cyclic type, in which the formation of ATP is coupled with a light-induced electron transport from water to ferredoxin and a concomitant evolution of oxygen and (b) a cyclic type which yields only ATP and produces no net change in the oxidation-reduction state of any electron donor or acceptor. Reduced ferredoxin formed in (a) serves as an electron donor for the reduction of NADP by an enzymic reaction that is independent of light. ATP, from both cyclic and noncyclic photophosphorylation, and reduced NADP jointly constitute the assimilatory power for the conversion of CO(2) to carbohydrates (3 moles of ATP and 2 moles of reduced NADP are required per mole of CO(2)).Investigations, mainly with whole cells, have shown that photosynthesis in green plants involves two photosystems, one (System II) that best uses light of "short" wavelength (lambda < 685 nm) and another (System I) that best uses light of "long" wavelength (lambda > 685 nm). Cyclic photophosphorylation in chloroplasts involves a System I photoreaction. Noncyclic photophosphorylation is widely held to involve a collaboration of two photoreactions: a short-wavelength photoreaction belonging to System II and a long-wavelength photoreaction belonging to System I. Recent findings, however, indicate that noncyclic photophosphorylation may include two short-wavelength, System II, photoreactions that operate in series and are joined by a "dark" electron-transport chain to which is coupled a phosphorylation site.


Familial immunopathy with chromosomal and functional abnormalities of lymphocytes.


Alterations in coelenterate malic dehydrogenase isoenzymes during temporary anaerobiosis.


Prescription of psychotropic drugs in Eastern Kentucky.


Studies on hydroid differentiation. VII. The hydrozoan stolon.


Microphallus: characteristics and choice of treatment from a study of 20 cases.


Nutritional status of British Columbia Indians. II. Anthropometric measurements, physical and dental examinations at Ahousat and Anaham.


The effect of iron and iron-8-oxyquinolinic chelate on the virulence of bacteria.


Proteolysis products of Candida albicans as a substratum for growth of staphylococcus aureus--a preliminary report.


Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems.


Effect of repeated administration of 2-deoxy-D-glucose or insulin on catechol-amine-synthesizing enzymes in rat adrenals.


Inhibition of NADPH-cytochrome c reductase by propyl gallate.


Microsomal metabolism of morphine in a hyperbaric helium environment.


Sympathetic activation of thyroid hormone secretion in mice.


Pyridine nucleotide stimulation of insulin release from isolated toadfish insulin secretion granules.


The in vivo and in vitro conversion of testosterone to 17 -hydroxy-5 -adrosten-3-one (dihydrotestosterone) by the sebaceous gland of hamsters.


Reductive metabolism of corticosterone in mice: differences in NADPH requirements of liver homogenates of males of two inbred strains.


Effect of adrenergic beta receptor blocking agents on cardiac output.


Differences in direct effects of adrenergic stimuli on coronary, cutaneous, and muscular vessels. Direct effects of adrenergic stimuli on coronary vessels in dogs were compared with effects on vessels to skin (hind paw) and skeletal muscle (gracilis muscle) after intravenous administration of practolol (2 mg/kg), a selective myocardial beta receptor blocker which minimized indirect effects of myocardial stimulation on coronary vascular resistance. The left circumflex coronary, cranial tibial, and gracilis arteries were perfused separately but simultaneously at constant flow. Perfusion pressures, left ventricular pressure and dP/dt. and heart rate were recorded. Changes in perfusion pressure to each bed reflected changes in vascular resistance. The direct constrictor effects of sympathetic nerve stimulation, norepinephrine and phenylephrine on coronary vessels were minimal compared with effects on cutaneous and muscular vessels. Subsequent blockade of vascular beta receptors did not augment the constrictor responses. Angiotensin, a nonadrenergic stimulus, produced striking coronary vasoconstriction which exceeded that in skin and approximated that in muscle. These results suggests that there is a paucity of alpha adrenergic receptors in coronary vessels compared to cutaneous and muscular vessels. Direct dilator responses to isoproterenol were similar in coronary and cutaneous vessels, but were greater in muscular vessels. Responses to glyceryl trinitrate, a nonadrenergic dilator, also were greater in skeletal muscle. Therefore, differences in effects of isoproterenol on the three beds may reflect differences in reactivity to dilator stimuli rather than differences in the density of beta receptors. In contrast to norepinephrine, the predominant direct effect of epinephrine on coronary vessels was dilatation mediated through activation of vascular beta receptors. A constrictor effect caused by stimulation of alpha receptors was unmasked by propranolol.Finally, the order of potency of agonists in stimulating coronary vascular beta receptors and the demonstration of selective beta receptor blockade with practolol suggest that beta receptors in coronary vessels resemble those in peripheral vessels more than those in myocardium.


Effects of phentolamine on electrophysiologic properties of isolated canine purkinje fibers.


Relationship between furosemide-induced volume depletion and reduction in hind limb blood flow.


Effects of a convulsant barbiturate on dorsal root ganglion cells and dorsal root discharges.


Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites). Neuroblastoma clones were examined for choline acetyltransferase (EC 2.3.1.6), tyrosine hydroxylase (EC 1.14.3.a), acetylcholinesterase (EC 3.1.1.7), and also for neurite formation. One clone does not form axons or dendrites. Three types of clones were found with respect to neurotransmitter synthesis: cholinergic, adrenergic, and clones that do not synthesize acetylcholine or catechols. All clones contain acetylcholinesterase. These results show that genes determining neurotransmitter species can be expressed in dividing cells, that the parental programs of gene expression are inherited, and that dividing cells can be programmed with respect to their ability to communicate with other cells.


Glutamic acid as a precursor to N-terminal pyroglutamic acid in mouse plasmacytoma protein (protein synthesis-initiation-immunoglobulins-pyrrolidone carboxylic acid). Cell suspensions derived from a mouse plasmacytoma (RPC-20) that secretes an immunoglobulin light chain containing N-terminal pyroglutamic acid can synthesize protein in vitro. Chromatographic examination of an enzymatic digest of protein labeled with glutamic acid shows only labeled glutamic acid and pyroglutamic acid; hydrolysis of protein from cells labeled with glutamine, however, yields substantial amounts of glutamic acid in addition to glutamine and pyroglutamic acid. The absence of glutamine synthetase and presence of glutaminase in plasmacytoma homogenates is consistent with these findings. These data indicate that N-terminal pyroglutamic acid can be derived from glutamic acid without prior conversion of glutamic acid to glutamine. Since free or bound forms of glutamine cyclize nonezymatically to pyroglutamate with ease, while glutamic acid does not, the data suggest that N-terminal pyroglutamic acid formation from glutamic acid is enzymatic rather than spontaneous.


Photoreactivity (365 nm) of some coumarins and 4',5'-dihydro-furocoumarins with nucleic acids.


Nuclear magnetic relaxation spectroscopy in solutions of bovine hemoglobin.


On the reaction between chlorophyll-a, and its primary electron donors in photosynthesis.


On the nature of the anti-dextran activity of the Helix pomatia "anti A" agglutinin.


Lipoamidase activity in virus induced tumours and in the corresponding normal tissue.


Biology of Echinococcus granulosus as it occurs in South India.


Oocyte differentiation and vitellogenesis in Glossina morsitans Westw.