Aryl hydrocarbon (benzopyrene) hydroxylase is stimulated in human lymphocytes by mitogens and benz(a)anthracene. A mixed-function oxidase that requires reduced nicotinamide adenine dinucleotide phosphate, is carbon monoxide sensitive, and is drug-metabolizing is present in human lymphocytes and is increased to different levels by treatment with phytohemagglutinin, pokeweed mitogen, and a polycyclic hydrocarbon.


Renal transplantation between histoincompatible rats. I. Acute rejection and prolonged survival of reciprocal renal allografts in immunocompetent rats.


Hepatic allotransplantation in the baboon. V. Preparation, characterization, and mode of action of a soluble donor spleen cell extract used to prolong graft survival.


Studies on postpartum rats accepting heart allografts: evidence for immunological enhancement.


Paucity of thymus-dependent cells in human marrow.


Increased or decreased graft-protective activity of antithymus serum absorbed with lymphoid cells.


Reactive lymphocyte blastogenesis during graft-versus-host reaction.


Studies on the pressor response to aminoalkyl derivatives of theophylline, noradrenalinetheophylline and norephedrinetheophylline.


Validity of important caries activity tests.


Fluorescence of nicotinamide adenine dinucleotides during the active transport of Ca 2+  ions in liver mitochondria.


Enzymatic conversion of chanoclavine-I.

Enzymatic conversion of chanoclavine-I.


A study on the mechanism of energy coupling in the redox chain. I. Transhydrogenase: the fourth site of the redox chain energy coupling.


The effect of alpha- and beta-receptor blocking agents on collagen-induced platelet release reaction. (A comparison with ADP-induced release).


Cooperation in growth of guanidine-dependent and guanidine-sensitive strains of Echoviruses 6 and 7 in the course of mixed infection of human embryo fibroblasts.


Cholinolytic activity of centrophenoxine.


Temperature mutants and recombinants of vaccinia virus. I. Genetic characteristics of temperature mutants.


Temperature mutants and recombinants of vaccinia virus. II. Recombination between temperature mutants.


Mutants of poxviruses resistant to acetone and N-methyl-isatin-beta-thiosemicarbazone.


Inhibition of cell culture respiration by influenza virus strains of different virulence.


Experimental pathogenicity of tick-borne encephalitis virus for dogs.


Viral infection and resistance in immunosuppressed host. I. Activation patterns of silent arbovirus infections.


Isolation of viruses from sera of healthy cattle.


Stabilization of Newcastle disease virus by dimethyl sulfoxide.


Some properties of temperature-sensitive mutants of poliovirus in two cell lines.


Photoreactivation of red clover mottle virus.


Distribution of antiviral and cell-inhibitory activity in interferon preparations.


Diagnostic preparations for the complement fixation reaction with lymphocytic choriomeningitis virus.


pH stability of red clover mottle virus.


Isolation in Portugal of West Nile virus from Anopheles maculipennis mosquitoes.


Isolation in the Moldavian S.S.R. of a Kemerovo group arbovirus from Ixodes ricinus ticks.


Infection of pigs with an influenza virus related to the A2-Hong Kong-1-68 strain.


The specific capsular polysaccharide of Pneumococcus type IV.


Coronary circulation in the conscious dog with cardiac neural ablation.


Volume loading and heart rate.

Volume loading and heart rate.


Inhibitors of lipolysis: potency and mode of action of  - and  -adrenolytics, methoxamine derivatives, prostaglandin E 1  and phenylisopropyl adenosine.


Adrenotropic drugs in lipid mobilization.


The role of cyclic AMP in the actions of some lipolytic and anti-lipolytic agents.


The effecs of methohexital in untreated and nalorphine-pretreated rats: metabolism and sleep times.


Reversible abnormalities in phagocytic function in poorly controlled diabetic patients.


The autonomic nervous system and some aspects of the use of autonomic drugs in children. II.


N-methyl bicuculline, a convulsant more potent than bicuculline.


Penicillin induced seizure activity in the hatchet fish.


Substrate utilization and glycolysis in the heart.


The effects of  -blocking drugs on atrioventricular conduction and contractility.


Sympathetic fibers in the aortic nerve of the cat.


GLC determination of sulthiame in plasma.


Biopharmaceutical studies on guaiacol glyceryl ether and related compounds. V.


Effects of total exposure to  60 Co  -radiation on cerebral nictoinamide nucleotides and glutathione in dogs.


Rapid immunological induction of murine lymphomas: evidence for a viral etiology. A graft-versus-host reaction induced in (SJL/J x C57BL/1)F(1) hybrid mice by injection of SJL/J spleen cells resulted in 100 percent incidence of tumors at 40 days. Transplantation studies revealed that the tumors were antigenically C57BL/1. Since both SJL/J and C57BL/1 mice carry tumorigenic virus, the evidence suggests a viral etiology.


The influence of beta-mimetic catecholamines upon the fetal circulation.


Detection of humoral and cell-mediated immunity to kidney basement membranes in human renal diseases.


In vivo piperazine ring degradation in neuroleptic and antihistaminic drugs.


The sympathoadrenergic system in the cardiovascular responses to hypoxia in the dog.


Catecholamines in turkeys with high or low blood pressure: effects of tyrosine hydroxylase inhibitor and ganglionic blocker.


Studies on the isolation of lymphocytes active in cell-mediated immune responses. 3. The pattern of recovery of immuno-competence by various lymphoid cell populations following cessation of chronic administration of antilymphocyte serum.


Studies on the isolation of lymphocytes active in cell-mediated immiune responses. II. Identification and recovery of an immunocompetent subpopulation of mouse thymocytes.


Pharmacological study of piroheptine, a new antiparkinson drug. II. Anticholinergic, antihistaminic, and psychopharmacological actions and toxicity.


Studies on the isolation of lymphocytes active in cell-mediated immune responses. I. Demonstration of an active population of thymus-derived cells in mouse bone marrow.


Tyrosine hydroxylation in the banana plant.


Angiographic and clinicophysiologic investigation of a case of polyarteritis nodosa.


Coenzyme binding to glutamate dehydrogenase. A study by relaxation kinetics.


Reactivity of lymphocytes from germfree rats in mixed leukocyte culture and in graft-versus-host reaction. The reactivity of lymphoid cells from germfree and conventional CDF rats were compared in mixed leukocyte culture (MLC) with both allogeneic rat leukocytes and with human leukocytes as stimulating cells, and in a graft-versus-host (GVH) assay. There was no difference between germfree and conventional rats in any of these systems. Furthermore, the increase in GVH activity after specific immunization against a strong histocompatibility antigen was small in both cases. The findings are incompatible with the hypothesis that the high proportion of antigen-sensitive cells against strong histocompatibility antigens is caused by cross-reactions between microbial antigens and histocompatibility antigens.


The allogeneic effect in inbred mice. I. Experimental conditions for the enhancement of hapten-specific secondary antibody responses by the graft-versus-host reaction. The administration of allogeneic lymphoid cells to 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH)-primed mice prepares such recipients for markedly enhanced secondary anti-DNP antibody responses to a DNP conjugate of a heterologous carrier. This allogeneic effect phenomenon, reflecting the development of a graft-versus-host (GVH) reaction, was first described in guinea pigs and has been extended in the present studies to inbred mice. The expression of the allogeneic effect in mice is dependent upon critical factors such as the number and route of administration of allogeneic cells, the time interval between cell transfer and secondary challenge, and the strength of histocompatibility differences between the donor and the host. The transient GVH reaction established by the transfer of allogeneic cells obviates the requirement for carrier-specific helper T cells in secondary anti-DNP responses, as evidenced by the ability to elicit such responses with DNP-D-GL, a substance which presumably does not stimulate effective T cell helper function. These studies also demonstrate that primed B cells which are not an integral part of the active GVH reaction fail to produce enhanced levels of antibody.


The allogeneic effect in inbred mice. II. Establishment of the cellular interactions required for enhancement of antibody production by the graft-versus-host reaction. Experimental conditions have been established for the elicitation of an allogeneic effect on the adoptive transfer secondary anti-2,4-dinitrophenyl (DNP) antibody response in mice. Thus, spleen cells from DNP-keyhole limpet hemocyanin (KLH)-primed mice manifest good secondary anti-DNP responses to a challenge with DNP-KLH, but not with DNP-bovine gamma globulin (BGG), after adoptive transfer to irradiated syngeneic recipients. However, a good adoptive transfer secondary anti-DNP response of such cells can be elicited with DNP-BGG when a second transfer of allogeneic lymphoid cells, in appropriate numbers, is carried out 24 hr before secondary challenge. The advantage to this system is that the DNP-primed cell population as well as the population of allogeneic lymphoid cells are accessible to experimental manipulation such that the T lymphocytes of one or the other can be removed. Utilizing this model, we have established that the allogeneic effect on antibody production can operate on a population of primed B lymphocytes which have been depleted of their isologous T lymphocytes by in vitro incubation with anti-theta serum plus complement. The potential cellular interactions involved in the mechanism of this phenomenon are considered and discussed in detail.


A comparison of two typologies for psychotics.


Acute obstructive laryngotracheobronchitis--report of six cases.


Effect of halothane on the hepatic drug metabolizing system.


Properties of the histamine stores affected in the anaphylactic and anaphylatoxin shock of the guinea pig. II. Effect of pretreatment with antigen.


Avoidance acquisition and CNS stimulants.


Elution studies in kidneys with linear deposition of immunoglobulin in glomeruli.


The soluble citric acid cycle enzymes of Drosophila melanogaster. II. Tissue and intracellular distribution of aconitase and NADP-dependent isocitrate dehydrogenase.


Studies on vasculitis. I. Immunoglobulins,  1C, C-reactive protein, and bacterial antigens in cutaneous vasculitis lesions.


Studies of 6-phosphogluconate dehydrogenase from sheep liver. 1. Kinetics of the reductive carboxylation reaction.


On the rate-limiting step in microsomal hydroxylation of steroids.


Studies of 6-phosphogluconate dehydrogenase from sheep liver. 2. Kinetics of the oxidative-decarboxylation reaction, coenzyme binding and analyses for metals.


The geographic pathology of dental disease in Canadian central arctic populations.


Cycloaddition of acetylenes to 7-acylamino-3-azidomethyl-3-cephem-4-carboxylic acids.


Synthesis and pharmacological properties of 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1,2-dialkylpyrrolidine derivatives.


Pharmacological actions of N-(2-o-methoxyphenoxyethyl)-6,7-dimethoxy-3,4-dihydro-2-(1H)-isoquinoline carboxamidine hydrobromide (SC-3123).


Larvae of culicine mosquitoes of Iraq with a key for their identification.


Metabolism of 4-(14C) testosterone by minced rat adrenal glands.


Ecological aspects of mosquito evolution.


The effect of puromycin on the biosynthesis of aldosterone in isolated adrenal mitochondria.


Elevation of serum gonadotropins (LH and FSH) after releasing hormone (LH-RH) injection in normal children and in patients with disorders of puberty.


Studies on benzoheterocyclic derivatives (IX). Structure-activity relations hips of 5 or 7 substituted 2-(3'-alkoxypropylaminomethyl) 2,3-dihydrobenzofuran analogues on analgesic, spinal reflex depressing and adrenergic -blocking effects.


Uptake and storage mechanism of 5-hydroxytryptamine in rabbit brain stem and effect of reserpine.


Mechanisms of activating contractions or relaxations in isolated helical strips of coronary artery.


Effect of dietary lipid on various liver enzymes and on in vivo removal of 3,4-dimethoxyphenylethylamine, 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan in rats.


The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle.


An ultrastructural investigation of spermiogenesis and the mature sperm in the anthozoan Bunodosoma cavernata (Cnidaria).


Heat increment of acetate and corn and effects of casein infusions with growing lambs.


The pharmacology of rapid eye movement sleep.


Effect of ferrous ion on tyrosine hydroxylase of bovine adrenal medulla.


Extreme virilization in a karyotypic female subject with congenital adrenocortical hyperplasia.


Microphotometric measurements of PN-fluorescence in isolated perfused liver.


Nuclear DNA content and minimum generation time in herbaceous plants.


The heterocysts of blue-green algae. 3. Differentiation and nitrogenase activity.


Rating scales for geriatric psychopharmacology--a review.


Central actions of dopa and dopamine.

Central actions of dopa and dopamine.


Serious infection after splenectomy for the staging of Hodgkin's disease.


Clinical pharmacology of 5-hydroxytryptamine and catecholamines venomotor receptors.


Cardiac toxicity of  -lytic drugs.

Cardiac toxicity of  -lytic drugs.


Ethanol and metyrapone effect on the redox potential, its compartimentalization, and its relation to the high energy phosphates of the rat liver in vivo.


Analysis of the adrenergic effects of various drugs.


N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla.


Pharmacological interference with the autonomic innervation of the urinary bladder of the cat.


Drug effects on cardiac inotropism.

Drug effects on cardiac inotropism.


An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondria.


Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor". An adenylate cyclase that is activated specifically by low concentrations of dopamine has been demonstrated in homogenates of caudate nucleus of rat brain. A half-maximal increase in the activity of the enzyme occurred in the presence of 4 muM dopamine. Concentrations of dopamine as low as 0.3 muM stimulated the activity of the enzyme. The adenylate cyclase activity of the homogenates was also stimulated by low concentrations of apomorphine, a substance known to mimic the physiological and pharmacological effects of dopamine. The stimulatory effect of dopamine was blocked by low concentrations of either haloperidol or chlorpromazine, agents known to block the actions of dopamine in mammalian brain. The results suggest that dopamine-sensitive adenylate cyclase may be the receptor for dopamine in mammalian brain. The isolation of this enzyme from caudate nucleus should facilitate the search for new therapeutic agents useful in the treatment of extrapyramidal diseases.


Ternary complexes in solution. XII. Models for biological mixed-ligand complexes: 2,2'-bipyridyl-Cu 2+ -oligoglycine systems.


Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate. Mouse neuroblastoma cells in culture have been used as a model for the study of the mechanism by which activities of tyrosine hydroxylase (EC 1.14.3.a) are regulated in sympathetic tissue. The activity of tyrosine hydroxylase in cultured cells drops to barely detectable activities after 1 week and remains low for months in culture in the uncloned cell line of neuroblastoma. Activity in an adrenergic clone isolated from the uncloned line has about 20% of the activity of the fresh grated tumor cell. N(6), O(2')-dibutyryl adenosine 3':5'-cyclic monophosphate causes a concentration and time-dependent increase in enzyme activity in both the cloned and uncloned cell lines. Enzyme activity is elevated by other stable analogs of adenosine 3':5'-cyclic monophosphate, notably the N(6)-monobutyryl, 8-aminomethyl, and 8-methylthio derivatives of the cyclic nucleotide; by the inhibitor of cyclic nucleotide phosphodiesterase, papaverine; and by sodium butyrate. Changes in cell morphology and tyrosine hydroxylase activity are shown not to be necessarily related.


Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids. Aryl hydrocarbon hydroxylase activity is inducible in mouse 3T3 fibroblasts by benz[alpha]anthracene, whereas no detectable basal or inducible levels of this enzyme occur in rat-hepatoma tissue culture cells. Conversely, tyrosine aminotransferase activity is inducible in hepatoma cells by dexamethasone, whereas only low noninducible levels of this enzyme exist in 3T3 cells. In hybrids formed by fusion of these two parent lines, levels of inducible hydroxylase activity range from the same as, to more than 20-fold greater than, that in the 3T3 parent; aminotransferase levels remain very low and noninducible in all of these same hybrids. A majority of the 1S-chromosomal complement from each parent is retained in most of these hybrids. The kinetics of hydroxylase induction and degradation, responses of hydroxylase induction to actinomycin D and cycloheximide, and the relative thermolability of the control and induced activities are similar in the 3T3 parent and in the hybrids. Failure to inactivate any of the aminotransferase activity in the hybrids with antibody specific for the rat enzyme indicates that all of the basal noninducible aminotransferase activity is derived from the mouse 3T3 parent.


Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ. Activity of serotonin N-acetyltransferase (EC 2.3.1.5) in rat pineal organ is rapidly and markedly elevated in vivo after administration of beta-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), norepinephrine, epinephrine, isoproterenol, monoamine oxidase inhibitors, or theophylline. Serotonin or 5-hydroxytryptophan has no effect on the increase in activity of this enzyme. Inhibitors of protein synthesis or propranolol, a beta-adrenergic blocking agent completely inhibit(s) the increase in activity of serotonin N-acetyltransferase induced by drugs, indicating that new enzyme molecules are formed via stimulation of beta-receptors of pineal cells and adenosine 3':5'-cyclic monophosphate. When rat pineal organ is denervated by ganglionectomy, beta-(3,4-dihydroxyphenyl)-L-alanine induces much more serotonin N-acetyltransferase than in the innervated gland. This superinduction by denervation appears to be due to changes of the postsynaptic site, probably the beta-adrenergic receptor on the pineal cell.


On the mechanism of electric response of the photoreceptors of the barnacle and other animals.


The effects on airways conductance of alpha-adrenergic stimulation and blocking.


Fusion of isolated mitochondria with tissue culture cells.


Enzymes as markers in virus preparations.


A new synthesis of furo(2,3-b)quinoline.


Lithium slows down the Kalanchoe clock.

Lithium slows down the Kalanchoe clock.


Aminopeptidases of Basidiomycetes.

Aminopeptidases of Basidiomycetes.


Enzymatic isolation of protoplasts from the liverwort Sphaerocarpus donnellii Aust.


Generation of reducing power in chemosynthesis. VII. Mechanism of pyridine nucleotide reduction by thiosulfate in the chemoautotroph Thiobacillus neopolitanus.


Bacterial degradation of p-methoxybenzoic acid.


The immunology of streptomycetes in terms of the cytoplasmic antigens.


Microbial conversion of p-hydroxyphenylacetic acid to homogentisic acid.


Acute bacterial meningitis in childhood: an outline of management.


Adrenergic manipulation and thyrotropin releasing hormone (TRH)-induced thyrotropin (TSH) release.


Polypharmacy in psychiatric treatment. Physician's treatment preference and practice survey.


Pediatric nurse practitioner. Analysis of potential training and utilization in New York State.


Priorities of resuscitation and subsequent therapy after trauma.


Experimental immunosuppression with L-asparaginase.


The place of the L-asparaginase in the treatment of acute leukemias.


An electron microscope study of the immediate effects on spermateleosis of a short-time experimental cryptorchidism in the rabbit.


Normal birth following exteriorization and intravenous injection of the early sheep fetus.


AAMI FDA National Conference on Medical Device Standards, Washington, D.C., May 20-21, 1972. Introduction.


The influence of drugs upon  42 K +  fluxes in guinea-pig ileum in vitro.


Interaction between cholinergic and catecholaminergic neurones in rat brain.


Adenosine cyclic 3',5'-monophosphate in fetal rat brain cell cultures. I. Effect of catecholamines.


The effect of cyclophosphamide on the ability of graft-versus-host reaction to suppress leukaemia in mice.


Application of the method of Magnus to measure drug antihistaminic activity in blood plasma.


Selective methods for the determination of brompheniramine and phenylpropanolamine in a sustained release tablet.


Recent advances in rheumatic diseases: the connective tissue diseases other than rheumatoid arthritis--1970 and 1971.


Acceptance of paramedical professionals.


Types of oral contraceptives, depression, and premenstrual symptoms.


History of depression as a risk factor for depression with oral contraceptives and discontinuance.


Comment on "functional speech disorders and personality".


The liver microsomal monooxygenase system in the human fetus: distribution in different centrifugal fractions.


Metabolism of ethylmorphine and aniline in human fetal liver.


Foot disability.

Foot disability.


Receptors for histamine can be detected on the surface of selected leukocytes. Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histaminie, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.


Correlation of beta blockade with serum practolol levels after oral administration.


The role of intraneuronal monoamine oxidase in the regulation of norepinephrine synthesis.


Rapid effects of monoamine oxidase inhibitors on synthesis and release of central monoamines.


Comparative aspects of prostaglandin biosynthesis in animal tissues.


The metabolism of 16-androstenes in boar salivary glands.


In-depth indexing of monograph literature for an on-line retrieval system: a pilot project. One of the unique features of the State University of New York (SUNY) Biomedical Communication Network is the availability of depth-indexed monograph information for on-line retrieval. Approximately 8,000 titles from the Upstate Medical Center Library collection in Syracuse, New York, were indexed in depth, chapter-by-chapter, as to subject content using the control vocabulary Medical Subject Headings. Detailed indexing of monographic conference proceedings was considered of particular importance to the project. This attempt to make monograph literature more readily accessible to medical library patrons is interesting from both a philosophical and a technical point of view. This paper will discuss both of these aspects, giving an overall description of the nature of this innovative project.


Inhibition of migration of peritoneal exudate cells depleted of circulating lymphocytes.


Direct involvement of NADPH oxidase with the stimulated respiratory and hexose monophosphate shunt activities in phagocytizing leukocytes.


Evaluation of factors effective in the determination of the transplanted fraction of colony-forming cells.


Investigation on arboviruses in western Sicily: insect collection and virus isolation.


Determination of oxygen consumption by use of the paramagnetic oxygen analyzer.


A mosquito survey of Guam, Marianas islands with notes on the vector borne disease potential.


Parasitism of mosquitoes by water mites.


Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man. Studies were performed in healthy volunteers to determine the effects of catecholamines and adrenergic-blocking agents on plasma and urinary levels of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP). Plasma cyclic AMP rose in response to infusions of the beta-adrenergic agent, isoproterenol, or in response to infusions of either epinephrine or norepinephrine alone or in combination with the alpha-adrenergic-blocking agent, phentolamine. Although urinary cyclic AMP also rose, the percentage increase was less than that observed in the plasma. These treatments caused no increase in plasma cyclic GMP. Plasma cyclic GMP rose in response to infusions of alpha-adrenergic agents, viz., epinephrine or norepinephrine infused together with the beta-blocking agent, propranolol. These treatments caused no increase in plasma cyclic AMP. These observations are consistent with the current concept that the actions of beta-adrenergic agents are mediated by increases in cyclic AMP formation in target tissues. Such a mediating role has not been established for cyclic GMP, but the data suggest the possibility that cyclic GMP metabolism is responsive either to alpha-adrenergic stimulation or to parasympathetic stimulation which occurs as a reflexive consequence of the pressor effect of alpha-adrenergic agents.


Sensilla on the antennae and palps of selected Wyeomyia mosquitoes.


Concentration and synthesis of acid-soluble nucleotides in myeloid tumour (Graffi) and normal mouse liver.


Prediction of therapeutic uses of psychotherapeutic drugs from experiences with normal volunteers.


Modification of ventricular fibrillation thresholds after sympatholytic drugs in the dog.


Stimulation of oxygen uptake of ferredoxin-NADP reductase-ferredoxin complex by cytochrome c.


Further studies on the pressor action of propranolol in the rat.


Socioeconomic pressure for new methods of health care delivery.


Nursing at Soviet's enterprises.

Nursing at Soviet's enterprises.


Physician's assistants- from a nurse's point of view.


Studies on new  -adrenergic blocking agents. I. Syntheses and pharmacology of coumarin derivatives.


The sympathetic nervous system and the regulation of cerebral blood flow.


Bactericidal and opsonic properties of C4-deficient guinea pig serum.


The influence of the aromatic amino acid side-chains on the sign of the Soret Cotton effect in chironomus hemoglobin (CTT 3).


On the biosynthesis of the benzimidazole bases occurring in corrinoids. Synthesis of 6',7'-dimethylnaphtho-(2',3')-imidazole-4,5 and 6',7'-dimethylnaphtho-(22',3')-imidazole-4,5-yl-cobamide.


High protective action against gamma radiation damage, by a tryptophan-ethanol mixture.


Studies on the mechanism of the photosensitized dimerization of pyrimidines.


Binding of a polycyclic hydrocarbon to mouse skin proteins.


RNA synthesis during "oogenesis to the onset of fertilization" in Limnaea (Mollusc).


Conformation analysis of the polypeptides in the thylakoid membrane.


p-Coumaroyl-meso-tartaric acid from spinach chloroplast preparations.


2-Carbethoxyindole derivatives. II. Synthesis of 8-benzyloxy-3H-pirydazino(4,5-b)indole-4-one.


Metabolism of tricarboxylic acid cycle in rat kidney medulla in vitro.


Sweat gland function in the red deer (Cervus elaphus).


Cardiovascular effects of chronic potassium deficiency in the dog.


Utilization of a microprogrammable computer for statistical analyses of data from a large epileptic patient population. I. Techniques and preliminary results.


Paving the way for new professionals.

Paving the way for new professionals.


A microfluorometric enzymatic assay for the determination of alanine and pyruvate in plasma and tissues.


Diagnosis of bacterial meningitis by counterimmunoelectrophoresis.


Feedback control of dopamine synthesis in dopaminergic terminals of the rat striatum.


In vitro myocardial effects of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956).


Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat.


Res ipsa loquitur. 4. Anesthesia.

Res ipsa loquitur. 4. Anesthesia.


Changes in rats during exposure to nitrous oxide at 7, 14 and 21 psi with physiologic levels of oxygen and nitrogen to a total pressure 36 psi.


Responses of blood lactate-pyruvate and redox state to chronic exposure to 3 per cent Co2.


The evaluation of testicular endocrine function before and in puberty. Effect of a single dose of human chorionic gonadotropin on urinary steroid excretion under normal and pathological conditions.


Helium effect on cardiac mitochondria of mice.


The use of the APL-360 system in pharmacology II--probit analysis.


Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate.


p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate.


Host-feeding patterns of Florida mosquitoes. I. Aedes, Anopheles, Coquillettidia, Mansonia and Psorophora.


Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine.


The presence of fucose, mannose, and glucosamine-containing heteropolysaccharide in collagen from the sea anemone Metridium dianthus.


A proposed mechanism for the TPNH enzymatic lipid peroxidizing system of rat liver microsomes.


Adaptive radiation and behaviour of the Malagasy lemurs.


Pyridine nucleotide transhydrogenases.

Pyridine nucleotide transhydrogenases.


Renal manifestations of connective tissue disorders.


Hyperdynamic circulation and hypertension.


The MEDEX medical occupation concept in subjective medical occupation-profession multidimensional space.


Relationships between Minnesota Multiphasic Personality Inventory socres and job performance measures of fire fighters.


The computer vs the technologist: comparison of psychological reports on normal and elevated MMPI profiles.


Ocular complications of drug therapy.

Ocular complications of drug therapy.


An epizootic of respiratory tract disease in Sprague-Dawley rats.


Current concepts in the pathogenesis and interval treatment of migraine.


Animal maintenance for biomedical evaluation of lunar material.


Enzyme activity and fiber composition in skeletal muscle of untrained and trained men.


Inert gas effects on embryonic development.


Atrial pacing in coronary artery disease.


The bacterial etiology and antibiotic management of septic arthritis in infants and children.


Delineation of chicken lymphocyte populations by specific anti-thymus and anti-bursa sera.


Simultaneous suppression of responses to allogeneic tissue in vitro and in vivo.


The bronchodilator effect of salbutamol administered by IPPB to patients with asthma. A controlled comparison with isoproterenol and placebo.


Occurrence of 19S and 7S anti-IgGs during hyperimmunization of rabbits with streptococci. All 110 rabbits immunized with Group A, A-variant, and C streptococcal vaccines produced 19S anti-IgG in addition to antibodies to the streptococcal carbohydrates. 19S anti-IgG was detected by hemagglutination of rabbit red blood cells coated with rabbit anti-blood group F antibody. Antisera of 88 of these animals were also tested for 7S anti-IgG with a coprecipitation assay. This assay is based on the coprecipitation of 7S anti-IgG with complexes of streptococcal carbohydrate and anti-carbohydrate antibody. 50 of the 88 anti-Group C streptococcal antisera contained 7S anti-IgGs. In eight antisera the concentration was greater than 5 mg/ml. The data suggest a genetic influence on the occurrence of 7S anti-IgG. The eight rabbits which produced more than 5 mg/ml of 7S anti-IgG belonged to three related families. Moreover, there were families in which almost every member produced 7S anti-IgG and other families in which only 30% of the members manufactured 7S anti-IgG. The streptococcal vaccine was an especially efficient stimulus for the production of 19S anti-IgG, whereas the pneumococcal vaccine was much less effective in this respect. Furthermore, 7S anti-IgGs were not detected in antipneumococcal antisera, although the concentration of anti-capsular antibodies was similar to that of anti-carbohydrate antibodies in antistreptococcal antisera.


Comparison of single topical applications of sodium fluoride and stannous fluoride.


Ontogeny of bursal function in chicken. 3. Immunocompletent cell for humoral immunity. To study the occurrence of immunocompetent cells directly responsible for antibody production, cells from yolk sac, embryonic liver, bursa of Fabricius, bone marrow, spleen, or thymus were injected together with SRBC and Brucella abortus into 4-day old cyclophosphamide-treated chicks. A second stimulation was given 4 days later, and samples taken 4 days thereafter were used for antibody titrations. During ontogeny, immunocompetent cells appeared in significant numbers first in the spleen for anti-SRBC responses, but in the bursa for anti-Brucella responses. Later these cells were also found in thymus and bone marrow. In the bursa, cells immunocompetent for anti-SRBC response were not encountered in significant numbers. The slight response to SRBC by transferred bursa cells reflects the presence of stem cells and their immediate descendents in the bursa at different stages of development. These findings are compared with the development and maturation of the stem cell responsible for humoral immunity. In the bursa, development of the stem cell population precedes that of immunocompetent cells. The opposite relationship was found in bone marrow, spleen, and thymus where immunocompetent cells were always present some weeks before the appearance of cells capable of achieving a long-lasting reconstitution of bursa-dependent functions. These observations reveal that the bursa seeds out immunocompetent cells during its entire postembryonic development, but does not release the lymphoid stem cell population before this population has matured sufficiently and before the bursa itself, after fulfilling its function, starts to involute.


Seminar on safety in the operating theatre.


Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F(1), F(2), and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.


Cardiovascular effects of M & B 17803A in man.


Bone marrow transplantation in patients with acute leukaemia.


Mechanisms of azo reduction by Streptococcus faecalis. I. Optimization of assay conditions.


Electromyographic studies of Parkinsonian patients.


Clinical evaluation of antihistamine, HS-592, in seasonal and perennial allergic rhinitis.


Comparative studies on the effect of the nerve growth factor on sympathetic ganglia and adrenal medulla in newborn rats.


Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats.


Temperature and metabolism in Leishmania. 3. Some dehydrogenases of L. donovani, L. mexicana, and L. tarentolae.


Influence of prostaglandins on adrenergic transmission to vascular smooth muscle.


Regulation of glutamine synthetase in cultured Chinese hamster cells. Induction and repression by glutamine.


Student psychotherapists' specialty choices and changes in their perceptions of self and patient.


Temporomandibular joint pain and dysfunction: a clinical study of emotional and occlusal components.


Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides.


Testicular function in hypopituitarism.

Testicular function in hypopituitarism.


A comparative study of two treatment schemes in clinical sinusitis.


Pneumococci producing beta hemolysis on agar. Fifty-six strains of pneumococci were studied for hemolysis on blood-agar Twenty-two (39%) of these strains produced beta hemolysis on agar containing horse red cells, six (11%) were beta hemolytic for sheep cells, and none lysed human or rabbit red cells. The substance producing beta hemolysis appeared after 24 hr of anaerobic incubation. Subsequent exposure to air at low temperature (6 to 20 C) for 48 hr was needed to activate it. There was no relation between serological type and beta hemolysis production. This substance appears to be different from the pneumococcal hemolysin previously described.


Cutaneous polyarteritis nodosa.

Cutaneous polyarteritis nodosa.


Electron microscopic histochemistry of cholinesterase in the posterior, intermediate, and anterior lobes of the rat pituitary.


Tooth germ transplantation.

Tooth germ transplantation.


The purification and properties of detergent-solubilized rat liver nucleotide pyrophosphatase.


Enzymatic   oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in   hydroxylation.


Experimental transmission of Venezuelan equine encephalitis virus by Deinocerites pseudes Dyar and Knab, 1909.


Allogenic tooth transplantation.

Allogenic tooth transplantation.


Hepatic microsomal ethanol oxidation. Mechanism and physiologic significance.


Neurologic manifestations of periarteritis nodosa (1972).


Thymus tissue as a therapeutic measure.

Thymus tissue as a therapeutic measure.


New anticoagulant for combating antibacterial activity of human blood. 1.


Effect of carotid artery occlusion and lung inflation on the main pulmonary artery. 1.


Variation in tyrosine aminotrasferase induction in HTC cell clones. Examination of tyrosine aminotransferase induction in many HTC cell subclones revealed a wide and unstable distribution of inducibility. The instability of this phenotype cannot easily be explained by classical mutation rates. These observations may be important in interpreting certain cell fusion experiments.


Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase. Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-beta-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine-betahydroxylase activity returned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis. possibly resulting in a persistent increase in aggressive behavior.


Cutaneous reactions to drugs with special reference to severe bullous mucocutaneous eruptions and sulphonamides.


Hereditary elliptocytosis. Haematological and metabolic findings.


Acute response of oxidative enzyme systems in epidermis subjected to beta-radiation.


The contribution of transferred allogeneic lymphocytes to the abrogation of sheep erythrocyte tolerance in rats.


The nature of the response of the cells of the sheep erythrocyte-tolerant rat to transferred allogeneic lymphocytes.


Potential vectors of arboviruses of cattle and buffalo in Australia.


Reactivity of D-amino acid oxidase with artificial electron acceptors.


Purification of tyrosine aminotransferase by affinity chromatography.


Isoenzymes of NADP + -and NAD + -glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rat adipose tissue.


Symptomatology and bacteriology correlated to radiological findings in acute maxillary sinusitis.


Enzymatic and electron microscopic analysis of isolated osteoclasts.


A primary preventive study of Gothenburg, Sweden.


Colony stimulating factor and allogeneic lymphocytes.


Transmission of malaria. 75th anniversary of Ronald Ross's great discovery.


Effect of various drugs on electrical and mechanical parameters of atrial muscle.


Behavioral effects of haloperidol after tyrosine hydroxylase inhibition.


Studies of 1-(o-cyclopropylphenoxy)-3-isopropylamino-2-propanol, a new  -adrenergic blocking drug.


The actions of angiotensin II on the isolated portal vein of the rat.


On the mechanism of adenylylation of glutamine synthetase from E. coli.


Treatment of Rhus dermatitis with non-prescription products.


An epizootic of shope fibromatosis in a commercial rabbitry.


Bovine anaplasmosis can be controlled.

Bovine anaplasmosis can be controlled.


Pneumococcic meningoencephalitis in a rhesus monkey.


Alteration of experimental cerebral vasospasm by adrenergic blockade.


Cerebral blood flow following induced subarachnoid hemorrhage in the monkey.


Genetic variation in activity of enzymes involved in synthesis of catecholamines. A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carried by the CBA/J strain appeared to be dominant to those of the other strains. The pattern of inheritance of tyrosine hydroxylase activity in adrenals differed from that in the brain. In both tissues, dominant genes appeared to determine intermediate, rather than extreme, levels of enzyme activities.


Decarboxylation of 3,4-dihydroxyphenylalanine (DOPA) by erythrocytes: a reaction promoted by methemoglobin and other ferriheme proteins. The decarboxylation of DOPA by erythrocyte hemolysates differs from DOPA decarboxylation catalyzed by aromatic aminoacid decarboxylases that contain vitamin B(6) in several significant respects. The ability of erythrocyte hemolysates to decarboxylate DOPA is associated with interaction between DOPA and methemoglobin; the ferriheme protein is reduced and DOPA is decarboxylated, probably after oxidation to a quinone intermediate. An analogous reaction takes place between DOPA and other ferriheme proteins, such as metmyoglobin and cytochrome c. This phenomenon may be of significance in relation to the side effects observed in patients with Parkinson's disease who are treated with very large doses of DOPA.


Twenty-fifth World Health Assembly. 2.

Twenty-fifth World Health Assembly. 2.


Specific suppression of the antibody response by antibodies to receptors. Balb/c myeloma proteins, TEPC 15 and MOPC 167, bind phosphorylcholine and precipitate with the C-polysaccharide moiety of pneumococci R36A. Anti-idiotypic antibodies to TEPC 15 myeloma raised in A/He mice prevent plaque formation by cells releasing antibody to phosphorylcholine and inhibit induction of the antibody response to phosphorylcholine in vitro and in vivo. This suppression is specific since antibodies against non-crossreacting idiotypic determinants of MOPC 167 do not prevent either formation of plaques or induction of the antibody response. Furthermore, the response to sheep erythrocytes is not suppressed by antibodies to TEPC 15. These results indicate that antibodies to phosphorylcholine and cell receptors for phosphorylcholine share similar antigen-binding sites with TEPC 15 myeloma protein. Thus, anti-idiotypic antibodies directed against TEPC 15 myeloma protein function as "anti-receptor" antibodies since they specifically prevent induction of the primary response to phosphorylcholine. It is proposed that antibodies to receptors may be involved in the homeostasis of the immune response.


Prevalence of dental caries in 2383 Moroccan school children aged eight and twelve.


The dental condition of 10-12-year-old children in Rangoon and Wolverhampton.


Simplified method for determining acetylator phenotype. A chemical method has been developed for estimating the acetylator phenotype without the use of special equipment. One urine specimen taken after ingestion of sulphadimidine, sulphapyridine, or sulphasalazine is required. The acetylator phenotype was assessed correctly in 150 urine specimens from 100 healthy subjects. Between 15 and 25 specimens can be determined hourly. Urine specimens for the test can be stored for two weeks at 37 degrees C without any loss of drugs or their metabolites.


Identification of prostaglandins in the gorgonian, Plexaura homomalla.


The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.


Bilateral pneumothorax and cardiovascular collapse on induction of anesthesia.


Catalytic activity of the monomeric form of D-amino acid oxidase in the presence of urea.


Hepatic metabolism of drugs.

Hepatic metabolism of drugs.


Synthesis of insect-repellent amino analogs of 2-ethyl-1,3-hexanediol (Rutgers 612).


Investigation of the gem-Dialkyl effect in medicinal agents.


Effects of irradiation on malignant cell cytoplasm.


Neuropharmacological actions of two new adrenergic beta-receptor antagonists, bunolol and H 64-52.


Chelation reactions of adenine.

Chelation reactions of adenine.


Studies on dehydrogenase levels in Uromastix hardwickii during active and hibernating periods.


The photoinactivation of tobacco transketolase in the presence of flavin mononucleotide.


A spectroscopic analysis of low-fluorescent mutants of Chlamydomonas reinhardti blocked in their water-splitting oxygen-evolving apparatus.


Energy-linked electron transfer reactions in Rhodopseudomonas viridis.


Coenzyme dependency of alcohol dehydrogenase in the retina of the rat. I. The effects of intraperitoneal injection of ethanol or methanol on the pyridine nucleotides of the liver and retina of the rat.


Coenzyme dependency of alcohol dehydrogenase in the retina of the rat. II. Histochemistry.


Human erythrocyte glucose 6-phosphate dehydrogenase: electron microscope studies on structure and interconversion of tetramers, dimers and monomers.


Observations of enzyme elevations in the serum during streptokinase treatment.


Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.


A comparison of the EEG effects of the potent antihistaminic (DL-chlorpheniramine) with a less potent isomer (L-chlorpheniramine).


Comparative corneal penetration and adrenergic mechanism of isoproterenol, epinephrine, levarterenol and compound AL842 in rabbits.


Salivation in mice as an index of adrenergic activity. II. The effects of atropines and ganglionic blocking agents on adrenergic salivation and temperature responses in mice.


Salivation in mice as an index of adrenergic activity. I. Salivation and temperature responses to d-amphetamine and other sialogogues and the effects of adrenergic blocking agents.


Salivation in mice as an index of adrenergic activity. 3. Partial temperature-dependence of adrenergic drug effects.


Chain shortening of acyl-coenzyme A by rat liver microsomes.


The legal status of the physician's assistant.


Electron transport activities in rat liver microsomal preparations isolated by various methods.


The fate of skin allografts in normal and experimentally altered guinea-pig testis.


Plasma testosterone and accessory sex glands in normal and cryptorchid rats.


Effect of various adrenergic receptor stimulating and blocking agents on human growth hormone secretion.


Urticaria.

Urticaria.


The use of disodium cromoglycate in seasonal rhinitis.


Double-blind crossover trial of depot tetracosactrin in hay fever.


Fat embolism--some clinical observations and a review of controversial aspects.


Effect of cold exposure on drug action and hepatic drug metabolism in the rat.


Modifications to culture techniques in the small teaching insectary.


Electrophoretic forms of glucose phosphate isomerase in oöcysts and blood parasites of Plasmodium berghei.


The effect of pituitary transplants on the tubero-infundibular dopamine neurons in various endocrine states.


MMPI profiles of disability insurance claimants.


Formation of 5 -reduced products from testosterone in vitro by germ cells from immature rats.


The effects of salicylate on the activity of rat liver tyrosine-2-oxoglutarate aminotransferase in vitro and in vivo. 1. Salicylate, in concentrations of 0.25mm and above, enhances the basal activity of tyrosine-2-oxoglutarate aminotransferase in homogenates of rat liver incubated in the absence of added pyridoxal 5'-phosphate (endogenous activity). The effect is decreased by increasing the concentration of the cofactor. 2. The intraperitoneal administration of sodium salicylate enhances the activity of rat liver tyrosine aminotransferase; the major effect during the first hour being on the enzyme in the absence of added pyridoxal phosphate. Actinomycin D prevents the induction of the enzyme by cortisol and tryptophan. Induction by pyridoxine or salicylate is 50% inhibited by actinomycin D. The effects of the injections of various combinations of cortisol, pyridoxine and salicylate were also studied in the absence or presence of actinomycin D. 3. It is suggested that salicylate induces rat liver tyrosine aminotransferase by displacing its protein-bound cofactor and that a cofactor-type induction of the hepatic enzyme occurs in pyridoxine-treated rats.


Periosteal reaction in polyarteritis nodosa.


The topical anticariogenic effect of daily rinsing with an acidulated phosphate fluoride solution.


Dimethyl acetamide and glycerol, nonspecific inactivators of receptor-effector systems in the isolated guinea-pig ileum.


Serum hepatitis with polyarteritis nodosa--a personal account.


Cardiovascular effects of 6-hydroxydopamine injected into a lateral brain ventricle of the rat.


Phenethylamine as a neurohumoral agent in brain.


Amino acids as central neurotransmitters.


The nigro-neostriatal pathway: the effects produced by iontophoretic dopamine.


Aminergic neurons and substitute transmitters in brain.


Cyclic AMP and neurotransmitters.

Cyclic AMP and neurotransmitters.


Central adrenergic receptors and the regulation of hunger and thirst.


Neural and hormonal control of catecholamine synthesis.


Experimentally induced parkinsonism.

Experimentally induced parkinsonism.


Electrical versus chemical neurotransmission.


Biochemical aspects of experimentally induced parkinsonism.


The synaptic actions mediated by the different branches of a single neuron.


Regulation of enzymes by small molecules.


Fibrin degradation products in rheumatoid arthritis.


Dental caries: distribution, by age-group, between the mesial and distal surfaces of human permanent mandibular incisors.


The distribution of clinical dental caries between the adjacent surfaces of neighbouring mandibular incisors.


The fermentation of L-sorbose by Gluconobacter melanogenus. I. General characteristics of the fermentation.


Effects of tranquillizers on tachycardia induced by adrenaline in the horse.


Evaluation of the pulse-contour method of determining stroke volume in man.


Evidence for a central activation of a vagal cardiodepressor reflex by clonidine.


Facilitation of vagal reflex bradycardia by an action of clonidine on central  -receptors.


Separation of vasodilator and negative chronotropic actions in analogues of adenosine.


What do we face and where can we go? Questions about future directions.


Relationship of stress to brain serotonin and 5-hydroxyindoleacetic acid.


Althesin and hydroxydione: comparative laboratory and clinical investigations.


A brief history of steroid anaesthesia before Althesin (CT1341).


Effect of mepyramine and spasmolytic agents on guinea-pig anaphylaxis with special reference to the protracted shock.


Contraction of the urinary bladder by muscarinic ganglionic stimulants: possible existence of muscarinic receptor sites on its parasympathetic ganglia.


A calorimetric study of the interaction of Mn 2+  with glutamine synthetase from Escherichia coli.


Some kinetics of the interaction of divalent cations with glutamine synthetase from Escherichia coli. Metal ion induced conformational changes.


Circular dichroic studies on the interaction of dihydrofolate reductase with substrates, coenzymes, and inhibitors.


Fluorometric estimation of 4-hydroxy-3-methoxyphenylethyleneglycol sulphate in brain. 1. A simple, sensitive, and selective method was developed for the fluorimetric estimation of 4-hydroxy-3-methoxyphenylethyleneglycol sulphate (MOPEG-SO(4)) in rat brain.2. MOPEG-SO(4) was isolated on a DEAE Sephadex column. Fluorescence was measured at 465 nm (excitation at 320 nm) after heating the column eluate with acid and reheating after adding ethylene diamine.3. The concentration in brain of MOPEG-SO(4) increased after blockade of its transport from brain by treatment with probenecid and decreased after inhibiting its synthesis by treatment with alpha-methyltyrosine or pargyline.4. Our studies suggest that measurement in changes in the rate of formation of MOPEG-SO(4) may be a useful index of noradrenaline turnover.


The regional and subcellular distribution of catechol-O-methyl transferase in the rat brain.


Regional distribution of tyrosine hydroxylase in rat brain.


Hog liver squalene synthetase: the partial purification of the particulate enzyme and kinetic analysis of the reaction.


Variation of the conformational states of Escherichia coli glutamine synthetase by interaction with different divalent cations.


Effects of cobaltous ion on various catalytic parameters and on heterologous subunit interactions of Escherichia coli glutamine synthetase.


TPNH-dependent binding of amethopterin by dihydrofolate reductase from Lactobacillus casei.


The paramedical courses in Denmark.

The paramedical courses in Denmark.


Glutamine synthetase from rice plant roots.


The vectorial release of nascent protein from membrane-bound thyroid ribosomes.


The influence of levodopa and adrenergic blockade on growth hormone and prolactin secretion in the MStTW15 tumor bearing rat.


Mitochondrial and cytosol malic enzyme in the testicular tissue of cod and rabbit.


Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components.


The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey.


Inhibition of ethanol-induced excitation in mice and rats by  -methyl-p-tyrosine.


The binding of oxidized coenzymes by glutamate dehydrogenase and the effects of glutarate and purine nucleotides. 1. The binding of NAD(+) and NADP(+) to glutamate dehydrogenase has been studied in sodium phosphate buffer, pH7.0, by equilibrium dialysis. Approximate values for the dissociation constants are 0.47 and 2.5mm respectively. For NAD(+) the value agrees with that estimated from initial-rate results. 2. In the presence of the substrate analogue glutarate both coenzymes are bound more firmly, and there is one active centre per enzyme subunit. The binding results cannot be described in terms of independent and identical active centres, and binding is stronger at low coenzyme concentrations than at high concentrations. Either the six subunits of the oligomer are not identical or there are negative interactions between them in the binding of coenzymes in ternary complexes with glutarate. The latter explanation is favoured. 3. The binding studies support the conclusions drawn from earlier kinetic studies of the glutamate reaction. 4. ADP and GTP respectively decrease and increase the affinity of the enzyme for NAD(+) and NADP(+), in both the presence and absence of glutarate. The negative binding interactions in the presence of glutarate are abolished by ADP, which decreases the affinity for the coenzymes at low concentrations of the latter. 5. In the presence of glutarate, GTP and NAD(+) or NADP(+), the association of enzyme oligomers is prevented, and the solubility of the enzyme is decreased; the complex of enzyme and ligands readily crystallizes. 6. The results are discussed in relation to earlier kinetic studies.


Effect of cordycepin on ribosome formation and enzyme induction in rat liver.


Synthesis of amino acids from succinate by the mitochondria of Neurospora crassa.


Handbook of materials and methods.

Handbook of materials and methods.


Physician assistant: one year with general practitioner.


A further study on the morphology and biochemistry of x-ray and dibutyryl cyclic AMP-induced differentiated neuroblastoma cells in culture.


Effect of cordycepin on induction of tyrosine aminotransferase employing hepatoma cells in tissue culture.


Effect of gonadotrophin stimulation of urinary steroid excretion after relocation of normal and cryptorchid testes in the boar.


Early heterografting of partial-thickness burns.


King's Fund transatlantic nursing seminar.


Stereospecificity of hydrogen transfer from NADPH by steroid   4 -5 - and   4 -5 -reductase.


Sulfoglucuronides from incubation of  3 H-estradiol-17  with rat liver microsomes.


Genetics and immunology of sex-linked antigens.


Phagocytosis and leucocyte enzymes in protein-calorie malnutrition. 1. Enzymes pertinent to bactericidal activities of leucocytes were assayed in children suffering from protein-calorie malnutrition. 2. Leucocytes obtained from malnourished and control children contained similar activities for glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Granule-bound NADPH oxidase activity was low in leucocytes isolated from malnourished patients and failed to show the phagocytic stimulation which is normally seen in control leucocytes. Further, leucocytes obtained from malnourished patients did not release the acid phosphatase from lysosomes during phagocytosis, unlike those from controls. 3. Treatment of the malnourishment with a diet high in calories and protein resulted in significant increase in the activities of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and NADPH oxidase and in releasing the acid phosphatase from the lysosomes into the supernatant fraction during phagocytosis. 4. The significance of these enzyme changes are discussed in relation to the increased susceptibility of these patients to infection.


Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides.


Heterogeneity and molecular weight inter-relationships of the esterase isoenzymes of several invertebrate species.


Effect of ethylene dibromide and carbon tetrachloride on lipid peroxidation in rat and chick liver.


Synergistic action of pyrazole on ethanol incoordination: differential metabolic and central nervous system effects.


-Adrenoceptors of aortae from genetically hypertensive rats: reaction with 2-halogenoethylamines.


Fluoridation.

Fluoridation.


Mouse caecum as a selective  -adrenoceptor tissue.


Some factors affecting the absorption of paracetamol.


The metabolic fate of quinine in rabbits.


Sex and species differences in the biliary excretion of tartrazine and lissamine fast yellow in the rat, guinea-pig and rabbit. The influence of sex hormones on tartrazine excretion in the rat.


The influence of some aliphatic alcohols on the enzymic hydrolysis of methyl hippurate.


Relations between particle shape, particle interaction and some rheological properties of hectorite dispersions.


The composition of phytosterols in first and second year Digitalis purpurea L.


Kinetics of some pyrazole derivatives in the rat.


An effect of ibuprofen and prednisolone on lysosomes.


Increased accumulation of ( 3 H) catecholamines formed from ( 3 H) dopa after treatment with caffeine and aminophylline.


The pressor action of 2,5-dimethoxy-4-methylamphetamine in rats.


Changes in the potency of aspirin in the presence of protein-bound dye.


The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats.


-Aminobutyrylcholine: actions on GABA and acetylcholine receptors.


Effects of dopamine, noradrenaline and 5-hydroxytryptamine on the cerebral blood flow in the dog.


Anti-inflammatory substance in human serum.


The recovery of Bacillus megaterium spores from white soft paraffin.


Perineal skin anchorage. A simple reliable method of orchiopexy.


Behavior of CNS single units in the vicinity of topically applied crystalline neurohumors.


Effects of 2, -4 dinitrophenol on release and uptake of noradrenaline in guinea pig heart.


Inhibition of the uptake of biogenic amines into mast cells by tricyclic psychoactive drugs.


Immunity deficiency in children.

Immunity deficiency in children.


Air controllers syndrome. Peptic ulcer in air traffic controllers.


The relationship of degenerative diseases to the blood pressure.


Maternal death study. Case report no. 6.


Mesenteric embolus. Case report.

Mesenteric embolus. Case report.


The value of the screening program on the incidence of sickle cell disease.


Society of critical medicine.

Society of critical medicine.


The view box: caustic esophagitis.

The view box: caustic esophagitis.


Elective interval appendectomy for recurrent right lower quandrant pain. Should the asymptomatic patient have surgery?


EKG of the month: left bundle branch block.


Studies on regulatory functions of malic enzymes. I. Metabolic functions of NAD- and NADP-linked malic enzymes in Escherichia coli.


Indirect correlation between hydroxylation activities and oxidation-reduction of cytochrome P-450.


Glucose-6-phosphate dehydrogenase from sweet potato: substrate-induced change in the sedimentation coefficient of the enzyme.


Structure and function of D-amino acid oxidase. IV. Electrophoretic and ultracentrifugal approach to the monomer-dimer equilibrium.


Suppression of graft-vs-host reaction by a spleen extract.


Hyperimmune response to a protein and a polypeptide antigen coated on pneumococcus R36A.


Plasmodium berghei NK65 in the inbred A-J mouse: age immunity in the female retired breeder A-J mouse.


Undetected carrier state in chronic granulomatous disease.


Plasmodium berghei NK65 in the inbred A-J mouse: immunity in the A-J mouse naturally recovered from NK65C and challenged with NK65E.


Phagocytosis as a surface phenomenon. Contact angles and phagocytosis of non-opsonized bacteria.


Antigenic relationship of normal hepatic organelle fraction to CxRP and the effect of CxRP and CRP on peroxisomal oxidase activity.


Differential acute effects of phenobarbital and 3-methylcholanthrene pretreatment on CCl 4 -induced hepatotoxicity in rats.


Comparison of the cardiovascular actions of NSC-109,724 (ifosfamide) and cyclophosphamide.


Effect of polyethylene glycol on the cardiovascular response of the dog to autonomic agents.


Human ecology and malaria.

Human ecology and malaria.


Alteration of renin release by stress and adrenergic receptor and related drugs in unanesthetized rats.


Genetic control of mosquitoes.

Genetic control of mosquitoes.


Jaundice following fluroxene anesthesia.


Sagittal tomography with gasserian ganglion block.


Reconstitution of photosystems I and II using spinach subchloroplast fragments fractionated by triton treatment.


The presence of P700 in chloroplast fragments prepared by short time incubation with triton X-100.


Physicians' assistants.

Physicians' assistants.


Bone marrow transplantation in a patient with drug-induced aplastic anemia. A 23-year-old woman gravely ill with Pseudomonas septicemia secondary to presumed drug-induced bone marrow aplasia received marrow transplantation from two male HL-A identical sibling donors. She had a successful engraftment with excellent but temporary clinical improvement. Subsequently she succumbed to graft-versus-host disease manifested by Pseudomonas and Candida albicans septicemia, cytomegalovirus pneumonitis, three phases of dermatitis, nausea, vomiting, dysphagia, diarrhea, fever, edema and bone pain, with gradual but complete graft suppression by the 74th day after the transplantation. A second marrow transplant on the 70th day was unsuccessful.


Stimulated granulocytopoiesis in mice bearing fibrosarcoma.


Social and psychological aspects of speed use. A study of types of speed users in Toronto.


Drug use among college females: socio-demographic and social psychological correlates.


Effects of histamine, 5-hydroxytryptamine and bradykinin on cattle and their modification by antagonists and by vagotomy.


Agitation of the solvent in tablet dissolution studies--a flow visualization technique.


Modification of acute systemic anaphylaxis in cattle by drugs and by vagotomy.


The effect of propranolol and atropine on venomotor reflexes in man. Venous reflexes--effect of propranolol and atropine.


Some aspects of the failure of sucrose tablets.


Determination of pharmacokinetic parameters for rapid and slow acetylators of sulphadimidine.


Inhibition of dopadecarboxylase in the rat by a series of benzyloxyamines.


Abolition of the morphine effect on body temperature in midbrain raphe lesioned rats.


A comparison between the negative inotropic action of various antiarrhythmic drugs and their influence on calcium movements in heart muscle.


Antagonism of prostaglandin F 2   induced bronchoconstriction and blood pressure changes by polyphloretin phosphate in the guinea-pig and cat.


The effect of  -phenethylamine upon spontaneous motor activity in mice: a dual effect on locomotor activity.


The effect of fourteen day treatment with diuretics on mouse blood sugar and glucose tolerance.


The relation between the subcellular distribution of [3H]resperpine and its proposed site of action.


The intraparticulate structure of calcium phosphate.


Microphotographic study of lyophilization of oil-in-water emulsions.


Skin reactions to prostaglandins.

Skin reactions to prostaglandins.


Blockade by pimozide of (+)-amphetamine-induced hyperkinesia in mice.


Clonidine-induced cardiovascular effects after stereotaxic application in the hypothalamus of rats.


The effect of L-dopa and (+)-amphetamine on the locomotor activity after pimozide and phenoxybenzamine.


9 -Tetrahydrocannabinol and its metabolites in monkey brains.


Some actions of dimethylsulphoxide at the neuromuscular junction.


Dimethylsulphoxide effect on myocardial  -adrenoceptors.


Noradrenaline effects and pH.

Noradrenaline effects and pH.


The biological estimation of free choline in tissues.


The quantitative determination of fluocinolone acetonide and acetonide acetate in formulated products by high pressure liquid chromatography.


Detection and identification of trace steroids in prednisolone.


Neuromuscular blocking and antimuscarinic activity of a series of bis-atropinium and N-n-alkyl atropinium compounds.


Effect of frusemide on the reactivity of rat portal vein.


On the localization of the hypotensive effect of L-dopa.


The central hypotensive action of amphetamine, ephedrine, phentermine, chlorphentermine and fenfluramine.


Binding of prostaglandin to human serum albumin.


Phenoxybenzamine blockade of neural and exogenous noradrenaline.


A common error in brain dopamine assays.


Effect of 6-hydroxydopamine on catecholamine concentrations and behaviour in the morphine-tolerant rat.


Antagonism by INPEA of isoprenaline-induced tachycardia in man.


Breath analysis of cannabis smokers.

Breath analysis of cannabis smokers.


A pimozide-sensitive effect of apomorphine on body temperature of the rabbit.


Potentiation of responses to and inhibition of extraneuronal metabolism of catecholamines by veratrine.


Phenitrone: ineffective blockade of (-)-trans-  9 -tetrahydrocannabinol in mice and dogs.


Effects of oestrogen, progesterone and betamethasone on the guinea-pig uterus.


3-Hydroxy-4-methoxyphenethylamine: the endogenous toxin of parkinsonism?


The tensile strength of deep concave tablets.


Effects of sympathomimetics on water movement across toad isolated bladder.


Physicochemical properties of spray-dried agglomerated particles of salicylic acid and sodium salicylate.


Structure of an iron-dextran complex.

Structure of an iron-dextran complex.


Application of orthogonal functions to spectrophotometric analysis: the  p j  method.


The fate of ( 14 C)disodium cromoglycate in man.


The pharmacokinetics of inulin and urea: a comparison of the dose eliminated from a compartmental model and that eliminated in urine.


Cholinesterase activity in the plasma and acid-secretory gastric mucosa of normal, castrated, and castrated oestrogen-treated male rats.


The effects of eserine and neostigmine on the guinea-pig ileum and on ileal longitudinal muscle strips.


Serum and brain concentrations of pentazocine in relation to analgesic activity in mice.


The antinociceptive activities of oxotremorine, physostigmine and dyflos.


Effects of a bicyclic thymoleptic drug (LU 3-010) on neuroeffector function in rat isolated portal veins.


The effect of chlorpromazine on drug metabolism.


Non-steroidal anti-inflammatory drugs and leucocyte emigration.


Spironolactone--a weak enzyme inducer in man.


Effect of chlorpromazine and some of its metabolites on the accumulation of homovanilic acid in brain of mice.


Evidence for alpha-methyl-m-tyrasmine as a false dopamine-like transmitter.


Reduction of acetylcholine output from the indirectly stimulated rat diaphragm preparation by some carbamates and phenols.


Activation of the antineoplastic drug isophosphamide by rat liver microsomes.


Nuclear magnetic resonance studies of interactions between oxyethylene-oxypropylene polymer, macrogol and phenol.


Apomorphine and its dopamine-like action.


The synthesis and analgesic and cns-suppressant activities of 2-amino-, 2-methylamino-, 2-dimethylamino-1,1-dimethyltetralin hydrochlorides.


Education and role of the physician. A redefinition.


Peyer's patch cells. Absence of graft-versus-host reactivity in mice and rats.


Pulmonary vasculitides. Importance of the clinical and pathologic differentiation.


Response of Class IV patients to alpha blockade prior to open-heart surgery.


Topical adrenergic potentiators in primary open-angle glaucoma.


Induced emesis--a questionable procedure for the treatment of acute poisoning.


Beta-adrenergic receptors in coronary and skeletal muscle arteries.


Peripheral distribution of cutaneous sympathetic vasodilator system.


Brain adrenergic system in the feeding response induced by 2-deoxy-D-glucose.


Immunochemical studies on the capsular polysaccharide of pneumococcal type IX. 1. In addition to the previously identified components, d-glucose, N-acetyl-d-glucosamine and d-glucuronic acid, the immunologically specific capsular polysaccharide of pneumococcal type IX (polysaccharide S IX) is now found to contain mannosamine and galactosamine, probably as their N-acetyl derivatives. 2. Partial hydrolysis yields a complex mixture of oligosaccharides, several of which have been separated. 3. One of these is alpha-d-glucuronopyranosyl-(1-->3)-d-glucose. It is an inhibitor of the precipitation of antipneumococcal type IX serum by polysaccharide S IX. 4. Two others, d-glucuronopyranosyl-(1-->3)-d-glucosamine and d-glucuronopyranosyl-(1-->3)-d-galactosamine have been identified and a trisaccharide and pentasaccharide partially characterized.


Combined treatment of atrial fibrillation with quinidine and beta-blockers.


Actions of beta-adrenergic blocking drugs assessed in patients with aortic Starr-Ewards prostheses.


Oxidation of the capsular polysaccharide of pneumococcal type IX by periodate. 1. The pneumococcal type IX polysaccharide (polysaccharide S IX) has been oxidized by sodium metaperiodate and reduced by sodium borohydride. Of the constituent monosaccharides, N-acetylglucosamine and N-acetylmannosamine remain unaltered, whereas 40% of the glucose and 90% of the glucuronic acid are oxidized. 2. The effect of oxidation and subsequent reduction on the precipitation of polysaccharide S IX in anti-(pneumococcal) sera is described and interpreted in structural terms. 3. Oligosaccharides produced by oxidation, reduction and hydrolysis with dilute acid have been isolated and partially characterized. 4. The results in this paper and the preceding one (Higginbotham et al., 1972) are used to postulate a possible structure for polysaccharide S IX.


Importance of intrinsic activity to action of practolol.


Controlled clinical trial of beta-adrenergic blockade in hypertrophic obstructive cardiomyopathy (HOCM).


Relationship between brain monoamine levels and Sidman avoidance behavior in rats treated with tyrosine and tryptophan hydroxylase inhibitors.


Mechanism of efferent inhibition of carotid body chemoreceptors in the cat.


The distribution of  -N-acetylglucosaminidase in marine invertebrates.


Regulation of blood pressure by sympathetic nerve fibers and adrenal medulla in normotensive and hypertensive rats.


Occurrence of 3-hydroxy-L-kynurenine in gorgonians.


Complexity of in vivo induction of tryptophan oxygenase and tyrosine aminotransferase: effects of tryptophan metabolites.


Recognition relations between macromolecules in growth, disease, aging, and the homograft reaction.


Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.


Premature labor: its management and therapy.


Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages.


Medical assistants--good or bad?

Medical assistants--good or bad?


Comparative study of the metabolic and bactericidal characteristics of severely glucose-6-phosphate dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with chronic granulomatous disease.


The elusive T cell receptor.

The elusive T cell receptor.


Intestinal transplantation.

Intestinal transplantation.


The demand for ophthalmic assistants.

The demand for ophthalmic assistants.


Nerve growth factor and preganglionic cholinergic nerves; their relative importance to the development of the terminal adrenergic neuron.


An attempt to develop an objective test battery for the selection of nursing students.


Effects of thermal acclimation on the lipid metabolism in the earthworm Lampito mauritii.


A comparison of activities of metabolic enzymes in lizards and rats.


Temperature and the kinetic analysis of trout isocitrate dehydrogenases.


Tricarboxylic acid cycle enzymes of the striped shore crab, Pachygrapsus crassipes.


Developmental changes in rat adrenal tyrosine hydroxylase, dipamine- -hydroxylase and catecholamine levels: effect of denervation.


Regional blood flow in anemia.

Regional blood flow in anemia.


Comparison of the standard MMPI and the Mini-Mult in a psychiatric outpatient clinic.


What is the sensation seeker? Personality trait and experience correlates of the Sensation-Seeking Scales.


Systematic relaxation as a nursing intervention technique with open heart surgery patients.


Assessing the diagnostic utility of MMPI and 16 PF indexes of homosexuality in a prison sample.


Resistance of inbred mice to Salmonella typhimurium.


Effects of cholinomimetics on adrenergic transmission.


Pharmacological characterisation of  -receptor blocking agents.


Arterial blood pressure decrease following adrenergic  -receptor stimulation in the central nervous system.


The Australian Council of Social Service.


Dental caries and diet in an Alaskan Eskimo population.


Pointers in the clinical diagnosis of acute peripheral nerve injuries.


Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. The ability of fourteen marine invertebrates to utilize [(14)C]mevalonate for the biosynthesis of isoprenoid compounds was investigated. Several of the animals, in particular crustaceans, bivalve molluscs, a coelenterate and a sponge, were unable to synthesize squalene and sterols, whereas gastropod molluscs, echinoderms, an annelid and a sponge could. Regardless of sterol-synthesizing ability the animals (with the exception of a sponge) always made dolichol and ubiquinone, and thus a specific block in squalene and sterol synthesis was indicated in some animals. Radioactivity accumulated in relatively large amounts in farnesol and geranylgeraniol in those animals incapable of making sterols.


Effect of hypobaric stress on enzymes of tryptophan metabolism. 1. On exposure of rats to hypobaric stress the tryptophan pyrrolase and tyrosine aminotransferase activities of the liver increased about threefold in 4h. 2. The tryptophan hydroxylase activity increased about 50% on exposure for 24h or more. 3. The increased activities reverted to the basal value on removal of the stress. 4. Treatment with cycloheximide inhibited the increase in the enzyme activities when the time of exposure was short (4h). However, the inhibitor-treated animals showed paradoxically high tyrosine aminotransferase activity on prolonged exposure (24h). 5. The pattern of haematin saturation indicated that the increase in pyrrolase activity under low pressure resembled that obtained with cortisol and not with tryptophan. 6. Repeated administration of cortisol or tryptophan did not have any effect on the activity of tryptophan hydroxylase. 7. The stress-induced increase in hydroxylase activity was not eliminated by the prior administration of 5-hydroxytryptophan to the animals.


The intermediary role of 5-pregnene-3 ,20 -diol in the biosynthesis of 16-unsaturated C 19  steroids in boar testis. 1. The possible involvement of 5-pregnene-3beta,20beta-diol in 16-unsaturated C(19) steroid biosynthesis has been investigated. 2. 5,16-Androstadien-3beta-ol (andien-beta) formation from [4-(14)C]pregnenolone (3beta-hydroxy-5-pregnen-20-one), 5-pregnene-3beta,20alpha-diol and 5-pregnene-3beta,20beta-diol was studied in homogenates of boar testis and the mean yields obtained were 25.6, 2.7 and 16.0% respectively. 3. Short-term kinetic studies with pregnenolone and 5-pregnene-3beta,20beta-diol separately and together suggested that the latter compound might be an intermediate in the biosynthesis of andien-beta. 4. In agreement with this interpretation, radioactive 5-pregnene-3beta,20beta-diol has been isolated during andien-beta biosynthesis from [4-(14)C]pregnenolone in the presence of NADPH, more radioactivity being trapped under limiting conditions of andien-beta formation with NADH present as cofactor. 5. Further, 5-pregnene-3beta,20beta-diol and andien-beta have been shown to inhibit the formation of the 16-unsaturated C(19) steroid from [4-(14)C]pregnenolone, the yield of radioactive 5-pregnene-3beta,20beta-diol increasing in the presence of added unlabelled andien-beta. 6. It is concluded that there may be two pathways leading to 16-unsaturated C(19) steroid formation from pregnenolone, one of these involving 5-pregnene-3beta,20beta-diol as an intermediate. Possible mechanisms are presented and discussed.


The respiratory-chain dehydrogenases of Azotobacter vinelandii.


The allosteric properties of the reduced nicotinamide-adenine dinucleotide phosphate dehydrogenase of Azotobacter vinelandii respiratory membranes.


The involvement of iron in the respiratory system of Azotobacter vinelandii.


Labelling of cholinergic receptors in subcellular fractions from rat cerebral cortex.


Output of ( 14 C)adenine derivatives on electrical excitation of tissues from the brain: calcium ion-sensitivity and an accompanying re-uptake process.


Mechanism of the decrease in coronary blood flow after beta-blockade in conscious dogs.


Steroid sex hormones as inhibitors of aflatoxin metabolism in liver homogenates.


Effect of lithium chloride on the rat's paw edema induced by serotonin, histamine and formalin.


Hemodynamic and pharmacological aspects of the biphasic pressor response to acetylcholine in atropinized dogs.


Immunochemistry of type XIV pneumococcus capsular polysaccharide oxidized by D-galactose oxidase.


The emerging concept of clinical immunology.


Sporozoite and normal salivary gland induced immunity in malaria.


The receptors concerned in the actions of catecholamines on glucose release, membrane potential and ion movements in guinea-pig liver. 1. Experiments have been made to identify the kinds of receptors concerned in the actions of catecholamines in increasing potassium efflux, membrane potential and glucose release in tissue slices prepared from guinea-pig liver.2. Glucose release could be accelerated by activation of either of two distinct receptors, one of which resembles the alpha receptor of Ahlquist's classification, the other being beta-like. Thus both amidephrine and isoprenaline (sympathomimetic amines which selectively activate alpha and beta receptors respectively) elicited the response.3. The effect of isoprenaline on glucose release was inhibited by the beta blocking agent propranolol (1 muM) but not by the alpha blocker phentolamine (10 muM), whereas the converse held for amidephrine. However, the degree of antagonism observed with phentolamine was less than found in smooth muscle, suggesting that the alpha-like receptor in the liver may differ somewhat from that in other tissues, or be less accessible to the antagonist.4. Amidephrine, like noradrenaline, increased the efflux of (42)K from the slices and caused hyperpolarization, suggesting that the increase in potassium permeability underlying these responses is alpha-mediated. This conclusion was supported by the finding that the effect of amidephrine on membrane potential was inhibited by phentolamine but not propranolol (1 muM).5. In keeping with this interpretation, low concentrations (20-50 nM) of isoprenaline, although sufficient to activate the beta receptors (as judged by the effect on glucose release) had little effect on the ionic composition of the tissue, and caused only a small increase in (42)K efflux. Thus the ;ion movement' and ;glucose' responses could be largely dissociated.6. Larger concentrations (1-6 muM) of isoprenaline increased (42)K efflux to a greater extent, although the effect was always less than with the same concentration of noradrenaline.7. Activation of the beta-receptors caused a small and inconsistent hyperpolarization which became more pronounced and also more reproducible on replacing the chloride content of the bathing fluid by the larger anion isethionate.8. Although these results show that activation of either of two distinct adrenergic receptors in guinea-pig liver can cause the same end-response (e.g. an increase in glucose release, or, under some circumstances, hyperpolarization of the cell membrane), the underlying mechanisms cannot be assumed to be identical. This is discussed.


Enhancement of aniline p-hydroxylation by acetone in rat liver microsomes.


Drugs and memory disorders in human aging.


Some studies on insolubilized nicotinamide nucleotides.


Regulation of the pentose phosphate pathway in the fungus Aspergillus nidulans.


Interaction of safrole and isosafrole with hepatic microsomal haemoproteins.


Dehydrogenation of DL-methylphenylcarbinol in the rat.


Single-step purification of dihydrofolate reductases on pteridine matrices.


Degradation of p-methoxybenzoate by cell-free extracts of Pseudomonas fluorescens.


Medical aspects of college football.

Medical aspects of college football.


Studies on the glutamate dehydrogenase from Neurospora crassa.


The post-ragweed syndrome.

The post-ragweed syndrome.


The subunit structure of the nicotinamide-adenine dinucleotide phosphate-dependent glutamate dehydrogenase of Neurospora crassa.


Osler-Rendu-Weber syndrome and Meckel's diverticulum.


The stereospecificity of nicotinamide-adenine dinucleotide-dependent oxidoreductases from plants. 1. The stereospecificity of 20 enzymes from plants is reported. 2. The stereospecificity of all known forms of malate dehydrogenase in plants and animals has been shown to be A-specific. 3. The generalization that ;the stereospecificity of a particular reaction is independent of the source of the enzyme' is confirmed for a total of 12 plant enzymes. 4. A new generalization is proposed: ;When a metabolic sequence involves consecutive nicotinamide-adenine dinucleotide-dependent reactions, the dehydrogenases have the same stereospecificity.'


Trends in gonorrhea ecology.

Trends in gonorrhea ecology.


The view box.

The view box.


Understanding phase II control. 2.

Understanding phase II control. 2.


An FDA overview of nutritional guidelines and nutritional labeling.


Maternal death study. Case report no. 7.


A plan for the organization of emergency services on Chicago's North Side.


EKG of the month.

EKG of the month.


"Hot-line" crisis counseling service.

"Hot-line" crisis counseling service.


The recrudescence of preventable communicable diseases.


Studies on aggregated multienzyme systems. Stimulation of oxygen uptake of ferredoxin-nicotinamide adenine dinucleotide phosphate reductase-ferredoxin complex by cytochrome.


Substrate independence of molecular weight of triphosphopyridine nucleotide-specific isocitrate dehydrogenase.


Lycopersene and prelycopersene pyrophosphate. Intermediates in carotene biosynthesis.


The relation between biological activity and the degree of resolution of optical isomers.


Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. VI. Solubilization and characterization of the electron transport chain. Membranes obtained from Escherichia coli have been solubilized with deoxycholate. The solubilized dehydrogenases and cytochromes are not sedimented at 105,000 g. These components readily penetrate the "included space" of Sepharose 4B (Pharmacia Fine Chemicals Inc., Uppsala, Sweden) and polyacrylamide gels and have been fractionated on the basis of molecular size. Solubilization destroys nicotinamide adenine dinucleotide, reduced form (NADH) oxidase and D-lactate oxidase activities, but leaves an appreciable part of the original succinoxidase activity intact. Evidence for a succinate dehydrogenase-cytochrome b(1) complex is given. Menadione added to the solubilized preparation does not elicit NADH oxidase activity nor stimulate the existing succinoxidase activity, but does provoke an active D-lactate oxidase activity. This D-lactate oxidase activity, however, does not use cytochromes and is not sensitive to cyanide.


Neuromuscular blocking and ganglion blocking activities of some acetylcholine antagonists in the cat.


Localization of ( 3 H)pimozide in the rat brain in relation to its anti-amphetamine potency.


A modification of rat adjuvant arthritis for testing antirheumatic drugs.


A rapid method for the determination of salicylate binding by the use of ultrafilters.


Titrimetric determination of sulphate in pharmaceutical products.


The effect of intra- and extragranular maize starch on the disintegration of compressed tablets.


A new spectrophotometric method for the determination of penicillins.


The influence of formulation variables on phase inversion temperatures of emulsions as determined by a programmed viscometric technique.


Cake thickness and deposition rate variation in a plate-and-frame filter press.


Relation between binding to plasma protein, apparent volume of distribution, and rate constants of disposition and elimination for chlorpromazine in three species.


Evidence of absorption of bromsulphthalein from the biliary system of the rat.


Antagonism by p-chlorophenylalanine of late tranylcypromine toxicity.


Effects of four cholinesterase inhibitors on the response of the guinea-pig isolated ileum to transmural electrical stimulation.


Interaction of fenfluramine analogues with the in vivo metabolism of (+)-amphetamine in the rat.


Do "loser" rats become "winners"?

Do "loser" rats become "winners"?


The content of (-)  9 -trans-tetrahydrocannabinol (  9 -thc) does not explain all biological activity of some Brazilian marihuana samples.


A comparison of Mg pemoline and (+)-amphetamine effects upon avoidance behaviour and the amine pump.


Changes in body core and skin temperature following intracerebroventricular injection of substances in the conscious rat: interpretation of data.


Effect of diazepam on  -aminobutyric acid (GABA) content of mouse brain.


A new method for the rapid determination of azovan blue leaked into the skin.


Recombination within the HL-A locus.

Recombination within the HL-A locus.


Transformaing principle of pneumococcus.


The effects of etafenone on the coronary and femoral circulations before and after adrenergic  -blockade in intact dogs.


Effect of cryptorchidism and castration of FSH and LH levels in the adult rat.


Ionized calcium concentration in saliva and its relationship to dental disease.


Amphetamine response in rat after dopamine neurone destruction.


Comparison of dental surveys in Elmira and Corning, New York.


Lysosome disruption by a free radical-like component generated during microsomal NADPH oxidase activity.


Regulatory properties of rat liver glutamine synthetase.


New horizons in surgical immunobiology. Host defence mechanisms in burns.


Reduction of D-amino acid oxidase by  -chloroalanine: enhancement of the reduction rate by cyanide.


Factors influencing photosynthetic enhancement in isolated chloroplasts.


Recent theories on the pharmacological basis of tolerance and dependence.


The psychological basis of drug dependence: the intellectual and personality characteristics of opiate users.


Lichen planus; an inborn error of metabolism.


The health care system looks at allied health personnel.


Manpower problem in obstetrics and gynecology: statistics and possible solutions.


The obstetric-gynecologic team: focus on the worker member.


The law and allied health personnel.

The law and allied health personnel.


The development of allied health personnel in pediatrics.


A special deoxyribonuclease activity accompanying competence-inducing activity.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1972.


Degradation of haem compounds to bile pigments.


Further evidence for posttranscriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells.


Dental status of La Tuna prisoners.

Dental status of La Tuna prisoners.


Comparison of the functional state of the liver in patients with positive and negative test for Australia antigen.


Enrichment of rhodopsin in rod outer segment membrane preparations. Biochemical aspects of the visual process. 18.


The in vivo seeding of hemopoietic colony-forming cells in irradiated mice.


Biological effects of heterologous antilymphocyte serum.


Principles of medical ethics.

Principles of medical ethics.


Medical legal information.

Medical legal information.


Nonidentity of the aspartate and the aromatic aminotransferase components of transaminase A in Escherichia coli. Tyrosine, added to the growth medium of a strain of Escherichia coli K-12 lacking transaminase B, repressed the tyrosine, phenylalanine, and tryptophan aminotransferase activities while leaving the aspartate aminotransferase activity unchanged. This suggested that the aspartate and the aromatic aminotransferase activities, previously believed to reside in the same protein, viz. transaminase A, are actually nonidentical. Further experiments showed that, upon incubation at 55 C, the aspartate aminotransferase of crude extracts was almost completely stable, whereas the tyrosine and phenylalanine activities were rapidly inactivated. Apoenzyme formation was faster, and apoenzyme degradation proceeded more slowly with aspartate aminotransferase than with tyrosine aminotransferase. Electrophoresis in polyacrylamide gels separated the aminotransferases. A more rapidly moving band contained tyrosine, phenylalanine, and tryptophan aminotransferases, and a slower band contained aspartate aminotransferase. A mutant of E. coli K-12 with low levels of aspartate aminotransferase exhibited unchanged levels of tyrosine aminotransferase. Thus, transaminase A appears to be made up of at least two proteins: one of broad specificity whose synthesis is repressed by tyrosine and another, specific for aspartate, which is not subject to repression by amino acids. The apparent molecular weights of both the aspartate and the aromatic aminotransferases, determined by gel filtration, were about 100,000.


Restoration of reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity of a Neurospora mutant by extracts of various chlorate-resistant mutants of Escherichia coli. Acid-treated extracts of Escherichia coli were tested for their ability to restore reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity to an extract of a Neurospora nit-1 mutant which produces a defective enzyme. With wild-type E. coli this complementation activity was more readily detected in the cytoplasmic fraction, although the nitrate reductase activity was found primarily in the particulate fraction. chlB mutants of E. coli appeared to have more complementation activity in the cytoplasm than was observed in the wild type, but no activity in the particulate fraction. The other chl mutants had little or no activity in either fraction. These results suggest that chlB mutants can produce a component or cofactor which is missing in the other mutants and in the Neurospora mutant, but cannot transfer it to the nitrate reductase enzyme.


Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12. Mutants of Escherichia coli in which the lysine-sensitive aspartokinase is feedback-resistant are described. In these strains, as well as in the wild type, aspartic semialdehyde dehydrogenase is subject to multivalent repression by lysine, threonine, and methionine. When these amino acids were added to a culture in minimal medium, the differential rate of synthesis of the enzyme dropped to zero and remained there for about one generation.


Mutant strains of Escherichia coli K-12 exhibiting enhanced sensitivity to 5-methyltryptophan. Eighteen mutants (designated MT(s)), isolated in Escherichia coli K-12, showed increased sensitivity to inhibition of growth by 5-methyltryptophan. All mutants were also much more sensitive to 4-methyltryptophan and 7-azatryptophan but exhibited near normal sensitivity to 5-fluorotryptophan and 6-fluorotryptophan. All of the mutations were linked to the trp operon. Their locations within the trp operon were established by deletion mapping. There was good agreement between the map position of an MT(s) mutation and a lowered activity of one of the tryptophan pathway enzymes. Three mutants, one of which contained a mutation that mapped within the trpE gene, were deficient in their ability to use glutamine as an amino donor in the formation of anthranilic acid. Another trpE mutation led to the production of an anthranilate synthetase with an increased sensitivity to feedback inhibition by tryptophan.


The role of surface sialic acid in adenovirus-cell adsorption.


The infectiousness of antigenic competition: conferrability of nonreactivity upon allogeneic T-cells.


Medical management of primary hypertension. 3.


Women who seek therapeutic abortion: a comparison with women who complete their pregnancies.


The treatment of chronic pain with psychotropic drugs.


Fluroxene toxicity in mice.

Fluroxene toxicity in mice.


Immunologic activities of pertussis-treated lymphocytes.


Haemodynamic and coronary effects of quazodine in cats with developing myocardial infarcts.


Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline levels and blood pressure in spontaneously hypertensive rats.


The effects of apomorphine, (+)-amphetamine and L-dopa on maximal electroshock convulsions--a comparative study in the rat and mouse.


Effects of narcotic analgesics on contractions of the chick isolated, innervated oesophagus.


Hypothermic effect of apomorphine in the mouse.


Influence of the electron-donating properties on the psychotropic activity of phenothiazine derivatives.


Gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma.


Determination of yield value of hectorite gels by the falling sphere method.


Some parameters describing the dissolution rate of salicylic acid at controlled pH.


Plasma levels in man of nitroglycerin after buccal administration.


Effect of micelle formation and the nature of the oil-phase on the distribution of a non-ionic surfactant in three- and four-component emulsions.


Noradrenaline excitation of cortical neurons: a reply.


The effect of L-dopa on neuroleptic-induced catalepsy.


Absence of potentiation of phenylephrine-induced cardiac necroses by theophylline. Selective inhibition by dihydroergocryptine and nicergoline.


Phosphatase activity of guinea-pig tissues on creatinol O-phosphate in vitro.


Kinin-like substances in saliva of larvae of wasps and hornets.


Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity.


Uptake of ( 14 C)xylocholine in mouse vas deferens after chemical sympathectomy.


Micelle formation by some antihistamines in aqueous solution.


Medical manpower and the emergence of new professions.


Action of some cardiovascular and neurohumoral agents on the formation of the chick embryo heart. I. Morphology.


Delegating tasks to physicians' assistants: physicians' reactions.


A toxic protein from the nematocysts of the scyphozoan medusa, Chrysaora quinquecirrha.


Double-stranded ribonucleic acid from maize rough dwarf virus.


Effect of cycloheximide on in vitro formation of rabbit granulocyte pyrogen induced with influenza A-PR8 virus or endotoxin.


Serum and bone marrow interferons in radiation chimeras.


Studies on bovine viral diarrhea-mucosal disease virus. I. Cultural behaviour and antigenic relationship of some strains.


Effect of Tween 80 on the haemagglutinating activity of group B arboviruses.