Irreversible cellular damage following a commonly employed iodination procedure.


A comparison of the efficacy of emetic drugs and stomach lavage.


Hay fever symptoms related to immunological findings.


Alleviation of experimental epilepsy by carotid artery ligation.


Hypotonia, mental retardation, obesity, and cryptorchidism associated with dwarfism and diabetes in children.


Syndrome associated with a deficiency of part of the long arm of chromosome no. 18.


Protection of reproductive capacity as a factor in therapy for undescended testicle.


Bacterial glycolipids. Glycosyl diglycerides in gram-positive bacteria. 1. The lipids of ten Gram-positive bacteria have been isolated and the presence in each of a glycosyl diglyceride was established. 2. The glycolipid fractions were isolated and deacylated to give water-soluble glycosides which were purified by paper chromatography. Partial structures for the glycosides have been deduced from chemical and enzymic studies. 3. Nine of the glycosides were disaccharides glycosidically linked to the 1-position of glycerol: the remaining glycoside contained a trisaccharide similarly linked to glycerol.


Catabolism of [4-14C]testosterone by subcellular fractions of human prostate. 1. Incubation conditions were established in experiments with human-prostate homogenates for almost complete conversion of [4-(14)C]testosterone into at least ten transformation products. 2. Whole homogenates of tissue with benign hypertrophy were shown to contain 3alpha-, 3beta- and 17beta-hydroxy steroid dehydrogenases, Delta(4)-3-oxo steroid 5alpha- and 5beta- reductases and unidentified hydroxylases. 3. Most of the 17beta-hydroxy steroid-dehydrogenase activity was located in the mitochondria, which showed little other activity. 4. The 3alpha- and 3beta-hydroxy steroid dehydrogenases and the 5beta-reductase were located in the high-speed supernatant and required supplementation with NADPH for activity. 5. The 5alpha-reductase was located in both microsomal and high-speed supernatant fractions and also required supplementation with NADPH.


Changes in the intracellular concentrations of adenosine phosphates and nicotinamide nucleotides during the aerobic growth cycle of yeast on different carbon sources. 1. Methods for the quantitative extraction of adenosine phosphates and nicotinamide nucleotides from yeast cells are described. 2. The intracellular concentrations of adenosine phosphates and nicotinamide nucleotides were measured during the aerobic growth cycle of yeast on glucose and galactose. 3. When sugars were still present in the media the intracellular concentrations of NADH and AMP were in general higher in glucose- than in galactose-grown cells, whereas ADP concentration was always lower in glucose-grown cells. 4. The adenylate-kinase reaction was found to be far from equilibrium in the glucose-grown cells and when glucose was still present in the growth medium. 5. The significance of the changes in the intracellular concentrations of adenosine phosphates and nicotinamide nucleotides observed during growth on either sugar is discussed in relation to the metabolism and growth of the cells. 6. The differences observed in the concentrations of these cofactors in glucose- and galactose-grown cells are also discussed in relation to the type of metabolism of these cells. Control of glycolysis at the level of phosphofructokinase in galactose-grown cells and at the level of phosphoglycerate kinase in glucose-grown cells is suggested. 7. ADP is suggested to be the inducer of formation of respiratory enzymes.


Clinicopathologic conference. Case presentation.


Polyarteritis nodosa.

Polyarteritis nodosa.


Separation of native and denatured fractions from partially denatured pneumococcal DNA.


Urinary excretion of taurine and creatine in radioprotected animals.


Fractionation of denatured pneumococcal DNA: evidence for resolution of complementary strands.


Altered responses to cortisol in precancerous liver.


Glutamate dehydrogenase concentration as a determinant in the effect of purine nucleotides on enzymatic activity.


Aldosterone synthesis by adrenal mitochondria. II. The effect of citric acid cycle intermediates; identification of the soluble stimulatory factor as fumarase.


Effects of thyroid status and adrenergic blocking drugs on isoproterenol-induced enlargement of the salivary glands.


Anesthesia LXX: effect of inert fluorinated agents on fluroxene and flurothyl.


Effect of hyperbaric oxygen on aerobic bacteria in vitro and in vivo.


Carbon monoxide concentrations and the effect of aminopterin on its production in the gas bladder of Physalia physalis.


Studies in hyperkinetic behavior. II. Laboratory and clinical evaluations of drug treatments.


The use and abuse of antihypertensive drugs in the aged.


IPPB therapy with bronkospray or isoproterenol--a comparison.


Personality profile in Menière's disease.


Further studies on the nasal flora of people of Papua-New Guinea.


Hemodynamic changes attending angiocardiography.


Enzymatic breakdown of UV-irradiated DNA by the extract from Micrococcus lysodeicticus.


Formation of enzyme bound carbon dioxide in the reductive carboxylation of alpha-ketoglutarate by isocitrate dehydrogenase.


The effect of glutathione and glucose-6-phosphate on fatty acid synthesis in E. coli.


Preservation of photophosphorylation in glycerinated chloroplasts.


The purification and properties of nitrite reductase from higher plants, and its dependence on ferredoxin. 1. NADPH-dependent nitrite reductase from the leaves of higher plants was purified at least 70-fold and separated into two enzyme fractions. The first enzyme, a diaphorase with ferredoxin-NADP-reductase activity, is required only to transfer electrons from NADPH to a suitable electron acceptor, which then donates electrons to nitrite reductase proper. 2. Purified nitrite reductase accepted electrons from ferredoxin (the natural donor) or from reduced dyes. Ferredoxin was reduced by illuminated chloroplasts or dithionite, or by NADPH when diaphorase was present. The purified enzyme did not accept electrons directly from NADPH. 3. Ferredoxins purified from maize, spinach or Clostridium were interchangeable in the nitrite-reductase system. 4. Nitrite reductase had K(m) 0.15mm for nitrite. The pH optimum varied with plant and method of assay. The preparation had low sulphite-reductase activity. Ammonia was the product of nitrite reduction. 5. For some plants, the assay of crude preparations with NADPH was limited by diaphorase and the addition of diaphorase gave a better estimate of nitrite-reductase activity. A simple method of assay is described that uses dithionite with benzyl viologen as electron donor.


Effect of oxidized glutathione on some enzymes of erythrocytes and its relation to erythrocytic enzyme activity and electrophoretic mobility. 1. Oxidized glutathione reacts or interacts with some erythrocytic enzymes (glucose 6-phosphate dehydrogenase, EC 1.1.1.49, aspartate aminotransferase, EC 2.6.1.10) but not with some others (lactate dehydrogenase, EC 1.1.1.27). 2. GSSG does not diminish the activity of any of these enzymes and is therefore not responsible for the decreased enzyme activities associated with older erythrocytes. 3. It may be that the reaction of aspartate aminotransferase with GSSG is the cause for the more rapid anodic electrophoretic mobility of this enzyme derived from human erythrocytes when compared with the mobility of the same enzyme from other human tissues. 4. A reinterpretation of some related, previously published, data with regard to the electrophoretic mobility of the above-mentioned enzymes from young and old erythrocytes is presented.


Light reduction of nitrate by chloroplasts depending on ferredoxin and NAD+.


Isolation of a chloroplast fragment fraction with NADP+-photoreducing activity dependent on plastocyanin and independent of cytochrome f.


Schizophrenia in twins: 16 years' consecutive admissions to a psychiatric clinic.


Transepithelial potentials in Hydra.

Transepithelial potentials in Hydra. There is a maintained electrical potential of 15 to 40 millivolts across the two epithelial layers forming the body wall of Hydra, the inside of the animal being positive. Negativegoing (depolarizing) spikes are recorded spontaneously and sometimes in response to depolarizing current pulses. These spikes usually overshoot the zero potential level. The large size of the spikes and the orientation of the potential difference across the body wall indicate that this electrical activity is epithelial rather than nervous in origin.


Accelerated painless labor.

Accelerated painless labor.


Bacteriologic studies of a trachomatous population.


Comparison of psychiatric symptoms in carcinoma of the pancreas with those in some other intra-abdominal neoplasms.


Fluoride tablets.

Fluoride tablets.


Salt fluoridation: an alternate measure to water fluoridation.


Glucose catabolism in Micrococcus sodonensis. The inability of Micrococcus sodonensis to grow on glucose as the sole source of carbon and energy was investigated. Estimation of pathways of glucose catabolism indicated that both the glycolytic and hexose monophosphate pathways are present in this organism. Comparative studies with Escherichia coli demonstrated that key enzymes for glucose catabolism were present in M. sodonensis in quantities equivalent to those of E. coli. The glucose-6-phosphate and 6-phosphogluconate dehydrogenases of M. sodonensis were nicotinamide adenine dinucleotide phosphate (NADP) specific, and glyceraldehyde-3-phosphate dehydrogenase was nicotinamide adenine dinucleotide specific. Transhydrogenase and reduced NADP oxidase were absent. Growth of the organism in the presence of glucose did not result in a repressed ability to oxidize tricarboxylic acid cycle intermediates, but these cells did have a decreased capacity for glucose degradation. The addition of substrates rich in growth-promoting substances, e.g., yeast extract, did not provide requisite nutrients for growth on glucose. Studies with (32)P suggest that M. sodonensis is incapable of synthesizing energy-rich phosphate compounds during the catabolism of glucose.


Transformation during mixed pneumococcal infection of mice. The recent demonstration by others of transformation during peritoneal infection of mice by two genetically distinct pneumococcal strains supports the notion that transformation may be significant in pneumococcal infection in nature. These studies confirm the occurrence of transformation during mixed infection of mice and define some conditions for its occurrence and its significance. Mice were inoculated with deoxyribonucleic acid (DNA) donor (small type III capsule, low virulence, streptomycin-susceptible) and recipient (noncapsulated, low virulence, streptomycin-resistant) pneumococci, and the bacteremia in mice that died was evaluated. Transformants (large type III capsule, virulent, streptomycin-resistant) were isolated from up to 80% of mice that died from mixed peritoneal infection. Transformation occurred in mice that received donor and recipient 6 hr apart; hence, active DNA was released and competence developed during growth in vivo. Transformation was detected only with progressive infection by both strains, and then transformants were few in the blood and apparently were not responsible for the death of the animals. In doubly infected mice treated with streptomycin, transformation was enhanced; transformants numerically dominated the bacteremia and seemed to cause the death of the mice. Transformation was also demonstrated for the first time during infection of the respiratory tract.


Orthophosphite-nicotinamide adenine dinucleotide oxidoreductase from Pseudomonas fluorescens. Information was obtained on the general properties and specificity of orthophosphite-nicotinamide adenine dinucleotide oxidoreductase. The enzyme was extracted from Pseudomonas fluorescens 195 grown in medium containing orthophosphite as the sole source of phosphorus. An enzyme preparation suitable for characterization was obtained from crude extracts by use of high-speed centrifugation, protamine sulfate precipitation, ammonium sulfate fractionation, and Sephadex gel filtration. The enzyme exhibited maximal activity at pH 7.0, and was inactivated within 6 min at 37 C. Arsenite, hypophosphite, nitrite, selenite, and tellurite were not oxidized by the enzyme. Sulfite inhibited the enzymatic oxidation of orthophosphite in an apparent competitive manner.


Recovery of donor deoxyribonucleic acid marker activity from eclipse in pneumococcal transformation. After the uptake of deoxyribonucleic acid (DNA), donor marker-transforming activity is temporarily lost. Restoration of the activity by annealing in vitro supports the idea that donor DNA is single-stranded at this stage. Kinetics of in vivo recovery from eclipse were examined for various markers at three temperatures. Sigmoidal recovery curves at lower temperatures indicate that the process consists of several steps. Rate of recovery was found to depend on the nature of the donor marker. Single-site markers recover much more rapidly than multisite markers corresponding to recipient deletions. Single-site markers vary somewhat in recovery rate, with rapidity of recovery inversely related to integration efficiency. Appearance of a recombinant-transforming activity lags only slightly behind recovery of its constituent donor marker.


Factors affecting the pathways of glucose catabolism and the tricarboxylic acid cycle in Pseudomonas natriegens. Less than 50% of theoretical oxygen uptake was observed when glucose was dissimilated by resting cells of Pseudomonas natriegens. Low oxygen uptakes were also observed when a variety of other substrates were dissimilated. When uniformly labeled glucose-(14)C was used as substrate, 56% of the label was shown to accumulate in these resting cells. This material consisted, in part, of a polysaccharide which, although it did not give typical glycogen reactions, yielded glucose after its hydrolysis. Resting cells previously cultivated on media containing glucose completely catabolized glucose and formed a large amount of pyruvate within 30 min. Resting cells cultivated in the absence of glucose catabolized glucose more slowly and produced little pyruvate. Pyruvate disappeared after further incubation. In this latter case, experimental results suggested (i) that pyruvate was converted to other acidic products (e.g., acetate and lactate) and (ii) that pyruvate was further catabolized via the tricarboxylic acid cycle. Growth on glucose repressed the level of key enzymes of the tricarboxylic acid cycle and of lactic dehydrogenase. Growth on glycerol stimulated the level of these enzymes. A low level of isocitratase, but not malate synthetase, was noted in extracts of glucose-grown cells. Isocitric dehydrogenase was shown to require nicotinamide adenine dinucleotide phosphate (NADP) as cofactor. Previous experiments have shown that reduced NADP (NADPH(2)) cannot be readily oxidized and that pyridine nucleotide transhydrogenase could not be detected in extracts. It was concluded that acetate, lactate, and pyruvate accumulate under growing conditions when P. natriegens is cultivated on glucose (i) because of a rapid initial catabolism of glucose via an aerobic glycolytic pathway and (ii) because of a sluggishly functioning tricarboxylic acid cycle due to the accumulation of NADPH(2) and to repressed levels of key enzymes.


Regulation of autotrophic and heterotrophic carbon dioxide fixation in Hydrogenomonas facilis. After growth on various carbon sources, sonic extracts of Hydrogenomonas facilis contained ribulosediphosphate (RuDP) carboxylase and phosphoribulokinase (Ru5-P kinase). After very short sonic treatment, a reductive adenosine triphosphate (ATP)-dependent incorporation of (14)CO(2) was also detectable. Reduced nicotinamide adenine dinucleotide (NADH(2)) served as reductant 30-fold more effectively than reduced nicotinamide adenine dinucleotide phosphate (NADPH(2)). Adenosine 5'-phosphate (AMP) and adenosine 5'-pyrophosphate (ADP) inhibited Ru5-P kinase and NADH(2)-, ATP-dependent CO(2) fixation. The levels and duration of CO(2) fixation suggested that it is a cyclic process. The requirement of reduced pyridine nucleotide and ATP and the sensitivity of fixation to AMP and ADP support the conjecture that it occurs via the Calvin cycle. After thorough study of variables affecting catalysis, specific activities (millimicromoles of substrate disappearing per milligram of protein) at 30 C were determined for RuDP carboxylase (C), Ru5-P kinase (K) and ATP-, NADH(2)- dependent CO(2) fixation (CO(2) F) after growth autotrophically on fructose, glucose, ribose, glutamate, lactate, succinate, and acetate. Values for these growth modes were, respectively-for C: 67.3, 51.1, 51.4, 24.6, 2.05, 10.2, 2.25, 1.4; for K: 24.7, 24.0, 23.2, 14.2, 12.8, 12.9, 13.4, 2.8; and for CO(2) F: 4.54, 4.83, 3.10, 2.87, 0.85, 1.51, 0.24, 0.41. The qualitative parallel between values for RuDP carboxylase and CO(2) fixation suggests that one major control point in fixation is the step catalyzed by RuDP carboxylase.


Regulation of glutamate dehydrogenases during morphogenesis of Schizophyllum commune. The specific activities of two glutamate dehydrogenases (GDH), one requiring nicotinamide adenine dinucleotide (NAD) and the other specific for nicotinamide adenine dinucleotide phosphate (NADP), varied during growth of Schizophyllum commune as a function of the stage of the life cycle and the exogenous nitrogen source. During basidiospore germination on either glucose-NH(3) or glucose-glutamate medium, NADP-GDH increased six- to eightfold in specific activity, whereas NAD-GDH was depressed. During dikaryotic mycelial growth on either nitrogen source, the two GDH increased in a 1:1 ratio, whereas, during homokaryotic mycelial growth on glucose-NH(3), NADP-GDH activity was depressed and NAD-GDH increased six- to eightfold. Homokaryotic mycelium cultured on glucose-glutamate medium yielded high NADP-GDH activities and normal NAD-GDH activities. Intracellular NH(3) concentration and NADP-GDH activities were inversely related during spore germination and homokaryotic mycelium growth, whereas guanosine-5'-triphosphate (GTP) and l-glutamine specifically inhibited NAD- and NADP-GDH respectively in vitro. GTP inhibition was shown in extracts from cells at all stages of the life cycle. Basidiospore germling extracts contained an NADP-GDH essentially resistant to l-glutamine inhibition.


A pharmacologic evaluation of hemicholinium analogs.


Relationships among cardiac inotropic responses to norepinephrine and cardiac and blood concentrations of H3-norepinephrine during hypothermia.


N-oxide formation: a new route for inactivation of the antihistaminic chlorcyclizine.


Interaction of magnesium with vasopressin intestinal smooth muscle.


Observations on the cariostatic effect of calcium sucrose phosphate in a group of children aged 5-17 years. Preliminary report.


The preparation and some properties of crystalline glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides.


Which hypotensive drug?

Which hypotensive drug?


Absence of serological evidence of myxoma virus infection in humans exposed during an outbreak of myxomatosis.


Polyarteritis nodosa-like disease in outbred mice.


Some pharmacological properties of a new adrenergic beta-receptor antagonist.


Renal blood flow in induced hypotension. The effects of THAM and sodium bicarbonate.


Effect of stellate ganglion blockade on the hyperpnea of exercise.


Pemoline and magnesium hydroxide versus pemoline: enhancement of learning and memory of a conditioned avoidance response in rats.


Some effects of chloroquine on oxidative processes in rat heart.


Histidine decarboxylase in experimental tumours.


Coating of pharmaceutical tablets: the spray-pan method.


The relation between noradrenaline content of rabbit heart muscle and the amount of k-strophanthin needed to produce arrhythmias.


The effects of acetates of aliphatic alcohols on the cholinergic nerve structures and the acetylcholine receptor of the guinea-pig ileum.


Complexation of penicillins and penicilloic acids by cupric ion.


The determination of nonylphenol ethylene oxide detergents in wool grease.


Apparatus for accelerated temperature cycling.


Hypotensive action of tyramine in cats.

Hypotensive action of tyramine in cats.


The effect of ethanol on the activity of central catecholamine neurones in rat brain.


Potentiation of noradrenaline toxicity by drugs with antihistamine activity.


The absorption of carrageenans.

The absorption of carrageenans.


Effect of amphetamine and reserpine on the pressor response to tyramine in the rabbit and cat.


Effect of pentobarbitone administration on corticosteroid-induced synthesis of hepatic gluconeogenic enzymes.


Biochemical effects of some newer salicylic acid congeners.


Failure of antihistamine to protect against histamine-induced duodenal ulceration in the guinea-pig.


Potentiation of the anticonvulsant action of acetazolamide.


A comparison of fluphenazine and chlorpromazine on critical flicker fusion frequency.


Interaction of gases with monolayers.

Interaction of gases with monolayers.


Spontaneous rupture of the kidneys due to polyarteritis nodosa: a case report.


The effect of bradykinin and anti-inflammatory agents on isolated arteries.


Effect of diet and atmosphere on intestinal and skin flora. I. Experimental data. NASA CR-661.


Development of an internal restraint system for an integrated restraint-pressure suit system. NASA CR-718.


Study of electrolytic dissociation of CO2-H2O using a solid oxide electrolyte. NASA CR-680.


Rheumatoid arthritis, polyarteritis, polymyositis, gastritis and Hashimoto's thyroiditis.


Psychiatric illness following therapeutic abortion.


Metabolism of 11-hydroxysteroids by cerebral tissues in vitro.


Influence of metopirone on substrate-supported hydroxylation of DOC by rat adrenal mitochondria.


Fate of histamine and N-acetylhistamine administered into the human gut.


Determination of enzymic demethylation of p-chloro-N-methylaniline. Assay of aniline and p-chloroaniline.


Studies on the mechanism of nidation. XXVI. Proestrous estrogen as a hormonal parameter of nidation.


On the significance of glucolysis for cancer growth, with special reference to Morris rat hepatomas.


Further studies with isocitric dehydrogenase in experimental tuberculosis: influence of isoniazid on metabolic damage.


Turnover of constituents of the endoplasmic reticulum membranes of rat hepatocytes.


Effect of sympathectomy and adrenalectomy upon ganglion blockade.


Mechanism of the vasodilator response to pheniprazine.


Biogenesis of endoplasmic reticulum membranes. II. Synthesis of constitutive microsomal enzymes in developing rat hepatocyte. The constitutive enzymes of microsomal membranes were investigated during a period of rapid ER development (from 3 days before to 8 days after birth) in rat hepatocytes. The activities studied (electron transport enzymes and phosphatases) appear at different times and increase at different rates. The increase in the enzyme activities tested was inhibited by Actinomycin D and puromycin. G-6-Pase and NADPH-cytochrome c reductase activities appeared first in the rough microsomes, and subsequently in smooth microsomes, eventually reaching a uniform concentration as in adult liver. The evidence suggests that the enzymes are synthesized in the rough part, then transferred to the smooth part, of the ER. Changes in the fat supplement of the maternal diet brought about changes in the fatty acid composition of microsomal phospholipids but did not influence the enzymic pattern of the suckling. Microsomes from 8-day-old and adult rats lose 95% of PLP and 80% of NADH-cytochrome c reductase activity after acetone-H(2)O (10:1) extraction. However, one-half the original activity could be regained by adding back phospholipid micelles prepared from purified phospholipid, or from lipid extracts of heart mitochondria, or of liver microsomes of 8-day or adult rats, thus demonstrating an activation of the enzyme by nonspecific phospholipid. The results suggest that during development the enzymic pattern is not influenced by the fatty acid or phospholipid composition of ER membranes.


Investigation of sympathetic activity resulting from a dose of acetylcholine producing a hypertensive response.


Relative ganglion-blocking potencies of cyclopropane, halothane and nitrous oxide, and the interaction of nitrous oxide with halothane.


The cardiac action of lysolecithin.

The cardiac action of lysolecithin.


A comparison of the antiarrhythmic actions of two new synthetic compounds, iproveratril and MJ 1999, with quinidine and pronethalol.


A preliminary investigation of the personality of female temporomandibular joint dysfunction patients.


Comparative metabolism of Chlamydia with special reference to catabolic activities.


A suggested mechanism for the selective procedure for isolating thymine-requiring mutants of Escherichia coli.


The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol.


The distribution of nicotinamide nucleotides during the life cycle of the blowfly Lucilia cuprina Wied. 1. Variations in the amounts and distribution of the nicotinamide coenzymes during the life cycle of the blowfly Lucilia cuprina have been investigated. 2. The concentrations of NAD and NADP declined to a minimum in mid-pupal life, then increased threefold from this to about 600 and 40mmumoles/g. fresh wt. respectively in the adult. 3. The NADH/NAD ratio was relatively constant (0.15) except in mid-pupal life (0.09); the NADPH/NADP ratio was lower (0.6) in larvae and mated adults than at other stages (0.90). 4. The increase in NAD content during development was greatest in the thorax, which finally contained about 75% of the total coenzyme. 5. Incorporation of NAD into the thoracic sarcosomes began about 2 days before ecdysis. Initially, most (77%) of the coenzyme was in particles 0.2-1mu in diameter, at a concentration of 11.1mmumoles/mg. of protein. During development there was a gradual appearance of NAD in larger particles (1-10mu) containing 2.8mmumoles/mg. of protein. 6. Similar but less marked changes occurred with NADP, which had a final concentration in the large particles of 0.01mmumole/mg. of protein.


Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito. 1. The disappearance of pyridine nucleotides during incubation with mosquito homogenates proceeds through the hydrolysis of the pyrophosphate linkage of these compounds as demonstrated by the formation of NMN and AMP from NAD(+). This reaction was also demonstrated by the loss in the coenzyme functioning property of NAD(+) (yeast alcohol dehydrogenase reaction) without a concomitant loss in reactivity towards cyanide. Transglycosidase activity was not observed in the mosquito homogenates, and low concentrations of nicotinamide did not inhibit the NAD(+) splitting activity of these homogenates. These observations are all in accord with the presence in these homogenates of a NAD(+) pyrophosphatase rather than a NADase. 2. The NAD(+) pyrophosphatase is destroyed by boiling, is not heat-activated, and has a pH optimum at pH8.75. In addition to NAD(+), other dinucleotides such as NADP(+), the 3-acetylpyridine and thionicotinamide analogues of NAD(+) and the thionicotinamide analogue of NADP(+), function as substrates in the hydrolysis catalysed by the pyrophosphatase. 3. A decrease in the specific activity of NAD(+) pyrophosphatase was observed during larval development, and a barely detectable activity was found in the pupa and adult. 4. Enzyme activity per organism increased in the larva but decreased to a very low value in the pupa and adult. These results indicate that the decrease in specific activity was due to a decrease in enzyme concentration rather than an increase in amounts of protein.


The role of the autonomic nervous system in extraocular muscle function.


Polyarteritis nodosa complicated by bilateral optic neuropathy.


The oxidative enzyme pattern in developing and adult mice and adult rabbits.


Case records of the Massachusetts General Hospital. Case 26-1967.


Study of the adrenal non-heme iron protein (adrenodoxin) by electron spin resonance.


Intestinal epithelial enzyme abnormalities induced by 5-fluorouracil: translocation of NADPH2-dehydrogenase.


NADP dependent oxidation of TDP-glucose by an enzyme system from sugar beets.


Bone nicotinamide adenine dinucleotide levels in response to nicotinamide and parathyroid extract injections.


Blood levels and cardiovascular dynamics during fluroxene anaesthesia in dogs.


Dental Ambassadors.

Dental Ambassadors.


Some social and economic factors relating to periodontal disease among Negroes. II. Observations on personality traits.


Spectroscopic examination of the solubilisation of benzoic acid by a non-ionic surfactant.


The flow of granular magnesia.

The flow of granular magnesia.


Effect of desipramine on directly or indirectly elicited catecholamine pressor responses in rats.


Effect of solubilisation on the antibacterial activity of hexachlorophane.


Aloe-emodin glycosides of senna leaf.

Aloe-emodin glycosides of senna leaf.


Water vapour transmission properties of free polymer films.


Isolation and characterisation of hepatotoxins from Penicillum rubrum.


Relationship of sialic acid to dental caries.


The fibrinolytic activity of anti-inflammatory drugs.


The effect of pregnancy on the central sympathetic components in angiotensin-induced hypertension.


Rabbit reactivity to cannabis preparations, pyraheaxyl and tetrahydrocannabinol.


Inhibition of valyl angiotensinamide II by osajin.


Complications of smallpox vaccination United States 1963. II. Results obtained by four statewide surveys.


Further observations on the somatic chromosome cytology of some mosquitoes (Diptera: Culicidae).


The effects of measured doses of fluoride. A five-year preliminary report.


Effect of cycloserines on D-amino acid oxidase.


Photosynthetic reactions with pyridine nucleotide analogs. II. 3-Pyridinealdehyde-diphosphopyridine nucleotide and 3-pyridinealdehyde-deamino-diphosphopyridine nucleotide.


Chloroplast reactions with dipyridyl salts.


Secretion of testosterone by the eutopic and the cryptorchid testes in the same dog.


Isoprenoid biosynthesis in a cell-free system from pea shoots. A cell-free system consisting of a soluble fraction and plastid fragments from pea shoots incorporates 2-(14)C-mevalonate very actively into farnesol, squalene, geranylgeraniol, and other isoprenoids of different carbon-chain lengths. The products have different cofactor requirements, which makes it possible to channel the pathway into different products by varying the incubation mixture.


Pemoline and magnesium hydroxide: lack of effect on RNA and protein synthesis. Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich ascites carcinoma cells.


Structural basis for the inhibition of protein biosynthesis: mode of action of tubulosine. A structural model for the inhibition of protein biosynthesis was previously formulated on the basis of a topochemical analogy between the ipecac alkaloids and the glutarimide antibiotics. The structure of tubulosine satisfies the requirements of this model. The prediction that such a compound would exhibit amebicidal activity and act by selectively inhibiting the transfer reaction in protein biosynthesis is confirmed.


Effect of pronethalol on the vasodilatory and lactic acid stimulating effects of adrenaline in the human forearm.


Uptake of some tritiated sympathomimetic amines by mouse brain cortex slices in vitro.


Cephaloridine: antimicrobial activity and pharmacologic behavior.


The reduction of DPN+ and TPN+ with sodium borohydride.


The frequency of physical illness as a function of prior psychological vulnerability and contemporary stress.


Tritium-labeled DPN+ and TPN+.

Tritium-labeled DPN+ and TPN+.


Properties of subchloroplast particles prepared by the action of digitonin, triton X-100, and sonication.


Studies on NADPH-cytochrome f reductase of chloroplasts.


Relation of phosphorylation to electron transport in isolated chloroplasts.


Study of the dispersion and flight range of Anopheles sergenti Theo. in Siwa Oasis using radioactive isotopes as markers.


Isolation of and ribonucleic acid synthesis  in nuclei of rat fetal liver.


The electron transfer chain in liver cell plasma membrane.


Pediatric editors' meeting--Tokyo, November 1965: a report.


Inversion and enhancement of the circular dichroic spectrum of flavin adenine dinucleotide by the combination to D-amino acid oxidase.


Studies on an energy-lined pyridine nucleotide transhydrogenase in photosynthetic bacteria. I. Demonstration of the reaction in Rhodospirillum rubrum.


Colonic motility in ulcerative colitis after opiate administration.


Phosphoadenosine diphosphate ribose, a specific inhibitor of nicotinamide adenine dinucleotide phosphate enzymes.


Initiation by glucagon of the premature development of tyrosine aminotransferase, serine dehydratase, and glucose-6-phosphatase in fetal rat liver.


Seminar on panoramic radiography: introductory remarks.


The effect of adrenergic blocking agents on plasma insulin and blood glucose during urethan or epinephrine induced hyperglycemia.


Use of an anticholinergic drug in the closure of an orofacial fistula due to noma. Report of a case.


Inhibition of anaphylactic shock in the rat by antihistamines and ascorbic acid.


A pharmacological investigation of human isolated stomach.


Effects of sympathomimetic amines on neuromuscular transmission.


The site of action of drugs on the isolated taenia caeci from the guinea-pig.


Receptors mediating some actions of histamine.


The effect of 2-halogenoalkylamines on the biological activity of some peptides.


On the mechanism of integration of transforming deoxyribonucleate. The characteristics of the intermediates in the reaction, between DNA and pneumococcus, that results in genetic transformation are described in so far as they have been characterized. Transformation with DNA isolated from bacteria carrying in addition to genetic markers (32)P as a radioactive label and (2)H and (15)N as density labels has permitted the characterization of the product of recombination between the newly introduced DNA and the DNA of a recipient bacterium. The evidence for a single strand displacement mechanism producing a hybrid structure in the DNA of the recipient bacteria is presented. Progeny of single transformants have been examined. The results of these segregation studies permit the further characterization of this hybrid product of transformation as a genetically heterozygous structure.


Personality and coronary heart disease: a review.


Genetic studies of recombining DNA in pneumococcal transformation. The results of genetic fine structure experiments, performed on the amiA locus of Pneumococcus are summarized. The peculiar feature of transformation genetics is that a given donor marker mutation transforms with an efficiency characteristic of the mutated site. In spite of this difficulty, mapping procedures have been devised and quantitative recombination studies performed. It is concluded from these studies that transformation, in this locus, is the consequence of frequent, and essentially random exchanges occurring between donor DNA and the chromosomal DNA of the recipient cell. The average length of uninterrupted donor DNA polynucleotide strand which could be inserted into the chromosome of a transformed cell is estimated, from genetic data, to be probably not greater than 3.10(5) daltons (for a double-stranded insertion). It is proposed, on the basis of genetic evidence, that following essentially random exchanges between donor DNA and recipient chromosome, a revision process, specific for certain types of mutated sites, occurs. The revision process appears to remove preferentially donor DNA sequences from the primary recombinant structure, and allow repair along the chromosomal template, leading to low efficiency in the genetic integration of these sites. A mechanism for this "destruction-choice" process is presented, and evidence in support of this mechanism discussed.


Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.


Smooth muscle stimulating action of N,N'-dibutyl-N,N'-dicarboxymorpholine-ethylenediamine.


Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.


Interactions of nicotine and tyramine with adrenergic blocking agents on ventricle strips.


The effect of reserpine treatment and the influence of pronethalol on free fatty acid levels in adipose tissue.


The influence of NADPH on the hydroxylation of progesterone by rat adrenal homogenates.


Properties and stabilization of the lysosomal membrane.


Changes in the liver concentrations of the nicotinamide adenine dinucleotide coenzymes and in the activities of oxidoreductase enzymes following treatment of the rat with ethyl chlorophenoxyisobutyrate (Atromid-S).


Microcontactor utilizing high density metallic superoxides.


Compounds acting on the central nervous system. IV. 4-substituted 2,3-polymethylenequinolines.


Further experience with peritalar dislocation.


The mechanism of the potentiation of norepinephrine by antihistaminics.


The effect of variations of pH upon the activation of phosphorylase by epinephrine in perfused contracting heart, liver slices and skeletal muscle.


Potentiation of actions of catecholamines by a derivative of hemicholinium.


Uncoupling of oxidative phosphorylation by ultrafiltrates of uremic serum.


Effects of nematocyst toxin of Physalia physalis (Portuguese Man-of-War) on the canine cardiovascular system.


Bushbush, Ieri and Lukuni viruses, three unrelated new agents isolated from Trinidadian forest mosquitoes.


Analysis of trace contaminants in closed ecologic atmospheres. SAM-TR-66-99.


The combustibility of materials in oxygen-helium and oxygen-nitrogen atmospheres. SAM-TR-66-85.


Analysis of trace contaminants contained in samples from a closed environment at 258 MM. Hg. SAM-TR-67-6.


Analysis of selected samples by microwave spectroscopy for trace contaminants collected from a space simulator. SAM-TR-67-3.


Bacterial mutation and the evolution of drug resistance in relation to chemotherapy.


Phase relationships in the simple coacervating system isoelectric gelatin: ethanol: water.


Correlates of somatic concern derived from psychological tests.


Clinical evaluation of a new theophylline derivative in the treatment of psychiatric patients.


The "nicotinic" and "muscarinic" receptors of the urinary bladder of the guinea-pig.


Gas-off studies of cabin materials. AMRL-TR-66-120.


Primary cross-leg flaps.

Primary cross-leg flaps.


Evaluation of fuel cell water for human consumption. AMRL-TR-66-141.


Analytical gas desorption apparatus. AMRL-TR-65-61.


Evaluation of water reclamation systems and analysis of recovered water for human consumption. AMRL-TR-66-137.


Oxygen supply system for manned space enclosures. AMRL-TR-66-169.


Biochemical and physiological evaluation of human subjects in a life support systems evaluator. AMRL-TR-66-159.


Toxicological screening of space cabin material. AMRL-TR-66-120.


Resume of manned experiments. AMRL-TR-66-120.


Contaminant studies in closed ecological systems at the USAF School of Aerospace Medicine. AMRL-TR-66-120.


A dangerous closed atmosphere toxicant, its source and identity. AMRL-TR-66-120.


Oxygen toxicity at near-ambient pressures. AMRL-TR-66-120.


Parts and materials data retrieval program relative to materials selection in toxicology. AMRL-TR-66-120.


Effects of some adrenergic blocking agents on gastric secretion in dogs.


The metabolism of the isomeric decalones. 1. The metabolism of (+/-)-cis-1-, (+/-)-trans-1-, (+/-)-cis-2- and (+/-)-trans-2-decalone in the rabbit has been investigated. 2. (+/-)-cis-2- and (+/-)-trans-2-Decalone were both reduced to racemic secondary alcohols, conformationally related to the ketones administered, and possessing an equatorial hydroxyl group. These alcohols were excreted in the urine as glucuronides in amounts equal to about half the dose administered. The glucuronides were isolated both as triacetyl methyl esters and as sodium salts. The ester obtained after feeding with (+/-)-cis-2-decalone proved to be methyl (cis-cis-2-decalyl tri-O-acetyl-beta-d-glucosid)uronate, whereas (+/-)-trans-2-decalone yielded methyl (trans-cis-2-decalyl tri-O-acetyl-beta-d-glucosid)uronate. The sodium salts were shown to be sodium (cis-cis-2-decalyl glucosid)uronate and sodium (trans-cis-2-decalyl glucosid)uronate. 3. Enzyme hydrolysis of the sodium salts and acid hydrolysis of the esters derived from (+/-)-cis-2-decalone yielded (+/-)-cis-cis-2-decalol, and of those from (+/-)-trans-2-decalone yielded (+/-)-trans-cis-2-decalol. 4. (+/-)-cis-1-Decalone was reduced mainly to (-)-cis-cis-1-decalol and excreted as [(-)-cis-cis-1-decalyl glucosid]-uronic acid. A small amount of the corresponding (+)-isomer was produced, yielding [(+)-cis-cis-1-decalyl glucosid]uronic acid on isolation. Enzyme hydrolysis of these compounds gave the corresponding aglycones; both alcohols possessed an equatorial hydroxyl group. 5. (+/-)-trans-1-Decalone was reduced to (+)-trans-trans-1-decalol, with an equatorial hydroxyl group, and in smaller amount to (+)-trans-cis-1-decalol possessing an axial group. The former alcohol was excreted as [(+)-trans-cis-1-decalyl glucosid]uronic acid, and the latter as [(+)-trans-cis-1-decalyl glucosid]uronic acid. 6. From a knowledge of the conformations, and in some cases the absolute configurations, of the compounds administered and excreted, and by making the assumption that the coenzyme concerned in the reductions is NADH (or NADPH), an explanation of the above findings in terms of steric hindrance and thermodynamic stability is given.


The specific substance from Pneumococcus type 34 the configuration of the glycosidic linkages. 1. The specific compound from Pneumococcus type 34 was isolated from capsular material by ion-exchange chromatography. This separated it from a substance with chemical and serological properties corresponding to those reported for C-substance. 2. The configuration of the two galactofuranosyl linkages in the repeating unit of S.34 was determined and the configurations previously assigned to the other glycosidic linkages were confirmed. 3. The dephosphorylated deacetylated repeating unit is thus O-beta-d-galactofuranosyl-(1-->3)-O-alpha-d-glucopyranosyl-(1-->2)-O-beta-d-galactofuranosyl-(1-->3)-O-alpha-d-galactopyranosyl- (1-->2)-ribitol.


Studies on dihydrofolic reductase, II. The activation of dihydrofolic reductase from chicken liver by iodine.


Nicotinamide adenine dinucleotides in the developing rat brain.


Stimulation by vitamin K3 of NADPH oxidation in liver microsomes.


A simple assay of monoamine oxidase and D-amino acid oxidase by measuring ammonia.


Reaction of D-amino acid oxidase with D-lysine.


The pleated surface of the undischarged thread of a nematocyst and its simulation by models.


The chemical, spectral, and biological properties of monomethine cyanine dyes containing 1,3-benzoxazine and quinazoline nuclei.


Biology of the simian malarias of Southeast Asia. 3. Sporogony of the Cambodian strain of Plasmodium cynomolgi.


Biology of the simian malarias of Southeast Asia. IV. Sporogony of four strains of Plasmodium cynomolgi.


Folate cofactor biosynthesis by Plasmodium berghei. Comparison of folate and dihydrofolate as substrates.


Magnesium pemoline: enhancement of memory after electroconvulsive shock in rats.


The effect of syrosingopine on spontaneous EEG and EEG arousal induced by external stimuli in rabbits.


The type-specific substance from Pneumococcus type 10A(34). Structure of the dephosphorylated repeating unit. 1. A hexasaccharide unit was isolated from the specific substance S. 10A from Pneumococcus type 10A (34) by hydrolysis with alkali followed by enzymic dephosphorylation. 2. The hexasaccharide was shown to be O-d-galactofuranosyl-(1-->3)-O-d- galactopyranosyl-(1-->4)-O-[d-galactofuranosyl- (1-->6)]-O-2-acet-amido-2-deoxy-d-galactopyranosyl- (1-->3)-O-d-galactopyranosyl-(1-->2)-ribitol.


The type-specific substance from Pneumococcus type 10A(34). The phosphodiester linkages. 1. The phosphate groups in the type-specific substance S. 10A from Pneumococcus type 10A (34) were shown to join the hydroxyl group at position 1 or 5 of ribitol and the hydroxyl group at position 5 or 6 of a d-galactofuranosyl residue in the next repeating unit. 2. A partial formula of the type-specific substance was derived.


Trinitrophenylation of D-amino-acid oxidase.


Optical rotatory dispersion and circular dichroism of D-amino acid oxidase.


The response of the microsomal delta 5-3-ketosteroid isomerase from several steroidogenic tissues to nicotinamide-adenine dinucleotides.


Stimulation by triphenyltetrazolium chloride of aerobic oxidation of NADPH2 by tumor microsomes.


A histological and ultrastructural study of germinal differentiation of interstitial cells arising from gland cells in Hydra viridis.


Accumulation of alpha-methyltyramine by the noradrenaline uptake process in the isolated rat heart.


The effect of butylated hydroxytoluene, butylated hydroxyanisole and octyl gallate upon liver weight and biphenyl 4-hydroxylase activity in the rat.


An analysis of the action of drugs on the circular muscle strips from the caecum of the guinea-pig.


Simultaneous polarographic determination of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole and 2-methyl-5-nitroimidazole.


The effect of frequency of coaxial electrical stimulation on the peristaltic activity of the guinea-pig isolated ileum.


The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea-pig to drugs and to coaxial stimulation.


A smooth muscle contracting substance in extracts of human umbilical cord.


Anticonvulsant and some neuropharmacological properties of 2-methyl-3-omicron-tolyl-6-chloro-4(3h)-quinazolone and related compounds.


A note on perfusion with labelled compounds to determine intestinal absorption.


Inhibition of amine uptake in tubero-infundibular dopamine neurones and in catecholamine cell bodies of the area postrema.


Central origin of the lenticular opacities induced in mice by opiates.


Effect of probenecid on the level of homovanillic acid in the corpus striatum.


Potentiation of the noradrenaline-releasing action of tyramine by monoamine oxidase inhibitors.


Differences in the response to insulin of pathogen-free mice and mice bred conventionally.


Fluorimetric detection of tranylcypromine in urine.


Alkaloids from Mitragyna javanica, Koord. and Valeton and Mitragyna hirsuta, Havil.


Inhibitory effect of 1-alkylbenzimidazoles on gastric secretion in the rat.


Concerning the regulation of some diverse biochemical reactions underlying the inflammatory response by salicylic acid, phenylbutazone and other acidic antirheumatic drugs.


The effects of barbiturates on the activity of the catecholamine neurones in the rat brain.


Hepatic lipid alterations produced by doxapram.


Flight research program--3. High impedance electrode techniques.


Concentrations of nicotinamide nucleotide coenzymes in micro-organisms.


Sampling problems in studies of psychosomatic disorders: difficulties in determining personality correlates.


Enzyme studies of skeletal muscle in mice with hereditary muscular dystrophy.


Pyridine nucleotides. II. Radiometric determination of minute quantities of triphosphopyridine nucleotides.


Cobamides and ribonucleotide reduction. V. A kinetic study of the ribonucleoside triphosphate reductase of Lactobacillus leichmannii.


Deoxyribonucleases of Pneumococcus.

Deoxyribonucleases of Pneumococcus.


Repetitive ventricular tachycardia--response to cardioversion, potassium and digitalis.


Complex reaction times at simulated cabin altitudes of 5,000 feet and 8,000 feet.


Coronary artery occlusion in the intact unanesthetized dog: intercoronary reflexes.


The distribution of palmityl-CoA: carnitine palmityltransferase in the animal kingdom.


Role of the phagocyte in host-parasite interactions. 8. Effect of whole-body x-irradiation on nicotinamides, lysosomal enzymes and bactericidal activities of leukocytes during phagocytosis. By studying the effects of whole-body X irradiation on phagocytosis, a correlation between the metabolic and bactericidal activities of leukocytes following X irradiation was demonstrated. The total nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) content of polymorphonuclear neutrolphils (PMN) isolated from irradiated guinea pigs increased significantly when compared to nonirradiated controls. The ratio of unreduced to reduced (NAD) generally increased in PMN isolated from irradiated animals. This occurred with both resting and phagocytizing cells. The ratio of unreduced to reduced NADP of resting PMN isolated from irradiated animals had a tendency to increase. However, in phagocytizing cells a significant decrease in the ratio was noted. The total acid and alkaline phosphatase and beta-glucuronidase increased up to about 10 days postirradiation. These lysosomal enzymes returned to approximately normal by the 17th day postirradiation. All three lysosomal enzymes (acid and alkaline phosphatases and beta-glucuronidase) were released from the granules at a significantly faster rate during phagocytosis after irradiation. The bactericidal activities of PMN isolated from irradiated animals gradually decreased, and in some cases increased growth of the organisms was observed. The uptake or association of bacteria with PMN isolated from irradiated animals varied with the postirradiation time. Generally, a correlation with bactericidal activities could be made. The data indicate that the bactericidal system in phagocytes consists of at least two agents, H(2)O(2) and myeloperoxidase.


Studies on pattern regulation in hydra. 3. Dynamic aspects of factors controlling hypostome formation.


Neuraminidase activities of clinical isolates of Diplococcus pneumoniae.


Studies on pattern regulation in hydra. II. Factors controlling hypostome formation.


Studies on pattern regulation in hydra. I. Regional differences in time required for hypostome determination.


An analysis of the chemical control of polarized form in hydra.


Some aspects of sexual polymorphism in chlorohydra viridissima.


A differential solvent effect on thermal stability of genetic markers in DNA.


Some physicochemical properties of the montmorillonites.


Effect of chronic nortriptyline pretreatment on the acute toxicity of various medicinal agents in rats.


Virus of the California encephalitis complex: isolation from Culiseta inornata. A virus of the California encephalitis complex was isolated from two pools of the mosquito Culiseta inornata, collected in mammalian burrows of Alberta during the summer of 1965. This is the first recorded isolation of California encephalitis virus from mosquitoes in Canada.


Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus. Radioactive choline is incorporated by pneumococcus (strain R36A) into a polymeric substance from which it can be quantitatively recovered as free choline, after hydrolysis by strong acid. The polymeric substance is insoluble in lipid solvents and can be degraded by periodate. Fractionation studies and chemical analyses suggest that choline is linked to a polysaccharide component of pneumococcal cell wall.


Environmental testing of contaminant producing materials from the integrated life support system. NASA CR-794.


The effects of cryptorchism in the guinea pig on the isoenzymes of testicular lactate dehydrogenase.


Denervation effects on the presumed de novo synthesis of muscle cholinesterase and the effects of acetylcholine availability on retinal cholinesterase.


Studies on P-450. I. Preparation and properties of a submitochondrial particulate fraction from bovine adrenal cortex.


Synaptosome pyridine nucleotide content.


Effect of hypothermia in dogs on anesthetizing and apneic doses of inhalation agents. Determination of the anesthetic index (Apnea/MAC).


Intrarenal arterial aneurysms.

Intrarenal arterial aneurysms.


Acetaldehyde oxidation by methanobacillus--a new ferredoxin-dependent reaction.


Chemi-osmotic theory of oxidative phosphorylation.


The undescended testis and torsion of the appendix of the epididymis. Three interesting and instructive cases.


Heritability of personality: a demonstration.


Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.


Further studies of the pharmacology of the pyloric region. Analysis of the effects of intra-arterial histamine, serotonin, phenyldiguanide, morphine, and other drugs on the antrum and duodenal bulb.


MMPI profiles of the parents of behaviorally disturbed children and parents from the general population.


A note on the extension of MMPI configural rules.


Electrical and contractile responses of the pyloric region to adrenergic and cholinergic drugs.


Family structure and pain reactivity.

Family structure and pain reactivity.


The effects of MMPI social introversion on WAIS PA performance.


The effect of historically based inferences on the behavior of withdrawn psychiatric patients.


Factor structure with the new set of MMPI scales and the formula correction.


Demographic variables and MMPI responses.


Estimation of CPI scores from MMPI protocols.


A comparison of repression-sensitization scores obtained by two different methods.


Dermal vasculitis with retinal involvement.


Problems of transplantation.

Problems of transplantation.


Ocular lesions in relapsing polychondritis and other rheumatoid syndromes. The Edward Jackson memorial lecture.


Inflammation induced by dimethylsulfoxide (DMSO). II. Ultrastructural investigation of the inflammatory phase.


The effects of instructed toothbrushing on the cleanliness of teeth and DMF: an eighteen-month study.


The primary biochemical effect of a morphological mutation in Neurospora crassa.


Studies on yeast mitochondria. 1. Existence of three phosphorylation sites along the respiratory chain of isolated yeast mitochondria.


Comparative pharmacology of some animal toxins.


Stability of erythrocytic reduced glutathione and nicotinadenine dinucleotide phosphate in HbE-thalassaemia disease.


Modification of drug responses by hydrolytic enzymes.


Some aspects of the comparative pharmacology of morphine.


Pharmacologic action of Physalia toxin.

Pharmacologic action of Physalia toxin.


The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus.


Cryptorchidism. Its pre- and postpubertal effects on the hypophysis of the rat.


Simple methods for the detection of tropinesterase activity in rabbits.


A basic model for the evaluation and prediction of preservative action.


The effect of pH and temperature on the lysis of yeast cells by cationic dyes and surfactants.


Lowering of plasma triglycerides as a result of decreased free fatty acid mobilization.


The effect of heparin on gastric secretion stimulated by histamine or ametazole hydrochloride.


The effect of tricyclic antidepressive drugs on adrenaline and adenosine diphosphate induced platelet aggregation.


Programmed learning and long-term retention.


Importance of noradrenaline synthesis for the interaction between desipramine and reserpine.


On the mechanism of the hyperglycaemic effect of chlorpromazine.


The intracerebral effects of noradrenaline and its modification by drugs in the mouse.


Inhibition of the taenia of the guinea-pig caecum by acetylcholine, nicotine or 5-hydroxytryptamine.


The role of dopamine in motor excitation of mice induced by brain catecholamine releasers.


On the mechanism of chlorpromazine-induced changes of cerebral homovanillic acid levels.


The importance of the nervous impulse flow for the depletion of the monoamines from central neurones by some drugs.


Effect of intermittent leg cuff inflation and intermittent exercise on the tilt table response after ten days bed recumbency.


Search for a cholinergic component in the sympathetic nerves to the perfused rabbit ear.


N,N'-di-n-butyl-N,N'-dicarboxypiperidine-ethylenediamine as a new potent respiratory stimulant.


Anticholinergic evaluation of 1,1-diphenyl-2-(1-methyl-3-pyrrolidyl) ethanol and N-(2'5'-dimethyl-1'-piperidylmethyl) benzilamide.


Energy-linked reactions in mitochondria: studies on the mechanism of the energy-linked transhydrogenase reaction.


Nitrate reductase electron transport systems in mutant and in wild-type strains of Neurospora.


Phagocytosis inhibition and reversal. II. Possible role of pyruvate as an alternative source of energy for particle uptake by guinea-pig leukocytes.


Stimulation of cholesterol metabolism in the luteinized rat ovary by luteinizing hormone.


A pressor response of the rabbit to nicotinic acid.


Effects of pronethalol on the cardiovascular actions of catecholamines during blockade by phenoxybenzamine.


The MMPI and the aged--some normative data from a community sample.


Mechanism of the central hypotensive action of guanethidine.


A recent occurrence of an African type tooth mutilation in Florida.


Oxidation of 7-dehydrocholesterol by a mouse liver microsomal system dependent on reduced pyridine nucleotides. Aerobic incubation of 7-dehydrocholesterol with mouse liver microsomes in the presence of a detergent, an iron salt, and NADH or NADPH resulted in the conversion of the sterol to more polar products. In the presence of Fe(3+) or low levels of Fe(2+) the reaction was dependent upon reduced pyridine nucleotide and a microsomal enzyme system. At high levels of Fe(2+) or in the presence of Fe(2+) or Fe(3+) and ascorbic acid, nonenzymatic oxidation of 7-dehydrocholesterol occurred in the absence of NADH or NADPH. Chromatograms of products resulting from the enzyme-dependent and enzyme-independent reactions were similar. The enzymatic reaction was inhibited by certain chelating agents, by antioxidants, and by menadione, phenazine methosulfate, and ferricyanide. Low concentrations of EDTA stimulated the reaction and high concentrations inhibited it. In the complete system sterol oxidation was correlated with the peroxidation of microsomal lipids, but peroxidation of microsomal lipids proceeded more rapidly when either the sterol, the detergent, or both were omitted. Ergosterol was resistant to oxidation under conditions that caused extensive loss of 7-dehydrocholesterol. Microsomes from tissues other than liver were relatively inactive.


Studies in histochemistry. LXXXVI. Quantitative histologic distribution in the rat adrenal of enzymes oxidizing pyridine nucleotides and effects of ACTH.


Neuroendocrine and metabolic effects of general anaesthesia and graded haemorrhage.


The blocking action of pronethalol on the contraction of isolated spleen strips produced by adrenaline, acetylcholine or isoproterenol.


Requirement of a new flavoprotein and a non-heme iron-containing protein in the steroid 11-beta- and 18-hydroxylase system.


Sympathetically mediated effects of angiotensin on the dog heart in situ.


MMPI decision rules for the identification of college maladjustment: a digital computer approach.


Substantive dimensions of self-report in the MMPI item pool.


Changes in the ultrastructure of chick embryo cells induced by infection with tick-borne encephalitis virus.


Plating efficiency of Semliki Forest virus; influence of caseinase C treatment of the virus.


Experimental pathogenesis of A-equi 1 influenza virus infection in horses.


Study on the pathogenesis of viral hepatitides.


Distribution area and natural hosts of latent viruses of monkeys. Occurrence of simian vacuolating virus (SV40) and Herpesvirus simiae in Cynomolgus monkeys in Indonesia.


Persistent infection of cell cultures with Coxiella burneti.


Penetration of tick-borne encephalitis virus into the thymus of mice.


Evidence about the type of nucleic acid contained in Kemerovo virus and related viruses.


Viraemia in mice experimentally infected with Kemerovo virus and related European viruses.


Serological survey and isolation of tick-borne encephalitis virus from the blood of the mole (Talpa europaea) in a natural focus.


A mutant of tick-borne encephalitis (TE) virus with lost neurovirulence for monkeys.


The adult adjustment of persons institutionalized as children.


Bone demineralization of foot and hand of gemini-titan IV, V and VII astronauts during orbital flight.


Respiratory failure with normal lungs.

Respiratory failure with normal lungs.


Biosynthesis of cholestanol: 5-alpha-cholestan-3-one reductase of rat liver. The 3-beta-hydroxysteroid dehydrogenase of rat liver which catalyzes the conversion of 5alpha-cholestan-3-one to 5alpha-cholestan-3beta-ol is localized mainly in the microsomal fraction. The enzyme required NADPH as hydrogen donor and differed from the known 3-beta-hydroxysteroid dehydrogenases of the C(19) series in being inactive in the presence of NADH. The microsomal preparations did not reduce the 3-keto groups of cholest-4-en-3-one, cholest-5-en-3-one, or 5beta-cholestan-3-one to the corresponding 3beta-hydroxy compounds. The conversion of 5alpha-cholestan-3-one to 5alpha-cholestan-3beta-ol was only slightly inhibited by the reaction product or by other monohydroxy steroids, but a strong inhibitory effect was noted with cholest-5-en-3-one, 5alpha-cholestane-3beta, 7alpha-diol and 5alpha-cholestan-7-on-3beta-ol. The microsomes, but not high speed supernatant solution, catalyzed the reverse of the cholestanone reductase reaction, namely the conversion of 5alpha-cholestan-3beta-ol to 5alpha-cholestan-3-one in the presence of oxygen and an NADP-generating system. The action of the microsomal preparations upon 5alpha-cholestan-3-one produced 5alpha-cholestan-3alpha-ol in addition to the 3beta-epimer. The 3-alpha-hydroxysteroid dehydrogenase involved functioned with either NADH or NADPH as hydrogen donor. The ratio of 5alpha-cholestan-3beta-ol to 5alpha-cholestan-3alpha-ol formed from 5alpha-cholestan-3-one was approximately 10:1 and was independent of the sex of the animal from which the microsomes were prepared.


Decreases in concentrations of the nicotinamide coenzymes in the livers of fasting pregnant sheep and of field cases of pregnancy toxaemia.


Electrophoretic studies of human placental dehydrogenases.


Periarteritis nodosa in a cat.

Periarteritis nodosa in a cat.


Dehydroquinate hydro-lyase and shikimate: NADP oxidoreductase in sliced roots of sweet potato.


Isozymes and genetic control of NADP-malate dehydrogenase in mice.


Electrochemical reduction of triphosphopyridine nucleotide.


Thioredoxin from Lactobacillus leichmannii and its role as hydrogen donor for ribonucleoside triphosphate reductase.


Glucose 6-phosphate-dehydrogenase activity in the preimplantation mouse embryo. 1. The activity of glucose 6-phosphate dehydrogenase was determined in mouse embryos during the first 5 days of development from the time of ovulation up to implantation. 2. The activity decreased from 1.39 to 0.19mmumoles of NADP reduced/hr./embryo from ovulation to implantation. 3. The specific activity of the embryo on the first day was higher than specific activities reported for most other tissues.


The effects of potassium ions and denervation on protein synthesis and the transport of amino acids in muscle. 1. The effects of varying concentrations of K(+) during incubation, of denervation and of various drugs on the accumulation of (14)C-labelled amino acids, their incorporation into protein and the stimulation of these processes by insulin in rat diaphragm preparations were studied. 2. The accumulation of glycine and aminoisobutyrate and incorporation of glycine into protein was less in tissue incubated in K(+)-free buffer or 20mm-K(+) than with 5-10mm-K(+). Incorporation of leucine was unaffected. 3. Incorporation into protein of amino acids by diaphragm that had been denervated 3 days previously was elevated. Accumulation of both glycine and aminoisobutyrate was also raised but that of phenylalanine was unaffected. 4. Accumulation of glycine by diaphragm and extensor digitorum longus muscle was decreased by a number of agents including cocaine and mepyramine. 5. The stimulation of incorporation by insulin was unaffected by changes in K(+) or in the presence of cocaine and mepyramine. Denervated tissue was markedly less responsive to insulin than its control. 6. The results are discussed in the context of the relation of amino acid accumulation to operation of the Na(+) pump and the influence of insulin thereon.


Nicotinamide-adenine dinucleotides in acute liver injury induced by ethionine, and a comparison with the effects of salicylate. 1. The effects of single doses of ethionine or sodium salicylate on the nicotinamide-adenine dinucleotide content of rat liver have been studied. 2. There was no significant change in the sum of NAD+NADH(2) during the early period (0-2hr.) of the liver injury induced by ethionine but there was a decrease in this value of approx. 30% by 4hr. after administration. 3. Ethionine had no significant effect on the NADP+NADPH(2) during the first 2hr. period after administration. The sum then decreased to a value approx. 70% of the control by 3hr. after dosing but showed a partial recovery at the 4hr. period before decreasing again in later stages of the poisoning. 4. Salicylate produced a very rapid decrease in the NADP+NADPH(2) in the liver after intraperitoneal injection. After 1hr. the decrease was approx. 30% of the initial value; the sum slowly returned towards the normal range during the following 4hr. 5. A high parenteral dose of salicylate was found to cause only a small depression in the concentration of ATP in rat liver in contrast with the rapid depletion produced by ethionine. 6. These results are discussed in terms of the liver disturbances produced by ethionine and salicylate.


Liver nucleotides in acute experimental liver injury induced by dimethylnitrosamine and by thioacetamide. 1. The concentrations of the nicotinamide-adenine dinucleotides in rat liver have been determined at intervals during the period 1-24hr. after feeding adult female rats with dimethylnitrosamine or thioacetamide. 2. The administration of dimethylnitrosamine resulted in a rapid decrease in the sum of NAD+NADH(2). This sum was decreased by 40% 3hr. after dosing. 3. Dimethylnitrosamine administration also produced an overall decrease in the NADP+NADPH(2) but this decrease was not so early nor as marked as that found for NAD+NADH(2). 4. The changes produced by thioacetamide were quite different from those obtained with dimethylnitrosamine. Thioacetamide produced a temporary rise in the NAD+NADH(2) followed by a small fall. The NADP+NADPH(2) was little changed in the early hours after dosing with thioacetamide but had decreased by approx. 15% 18hr. after administration. 5. These changes are discussed in terms of the known hepatotoxic actions of dimethylnitrosamine and thioacetamide, and are compared with previously reported changes found after the administration of carbon tetrachloride.


Differentiation of the barbiturate stimulation of the glucuronic acid pathway from de novo enzyme synthesis.


Glucose metabolism in the mucosa of the small intestine. Enzymes of the pentose phosphate pathway. 1. The occurrence of five enzymes of the pentose phosphate pathway in cell-free preparations of the mucosa of rat small intestine is described. These enzymes were found to be localized mainly in the supernatant fraction (6240000g-min.). 2. The properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were studied with respect to K(m) values for substrates and NADP(+), pH optima and the effects of p-chloromercuribenzoate and palmitoyl-CoA. Higher total and specific activities of these two dehydrogenases were noted in the proximal half of the small intestine of the rat than in the distal half. 3. The specific activities of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the mucosa of the small intestine of the rat, cat, rabbit and guinea pig were compared. 4. In the rat the specific activities of ribose 5-phosphate isomerase, transketolase and transaldolase were higher in the supernatant fractions from the intestinal mucosa than in those from the liver. 5. The role of the pentose phosphate pathway is discussed in relation to the metabolism of hexose phosphates in the intestinal mucosa.


Antagonism between stereoisomeric amphetamines, amphetamine derivatives and other monoamine oxidase inhibitors.


On the existence of spectrally distinct classes of flavoprotein semiquinones. A new method for the quantitative production of flavoprotein semiquinones.


Studies on a barley mutant lacking chlorophyll b. I. Photochemical activity of isolated chloroplasts.


Measurements of reduced pyridine nucleotides in a single neuron.


Semiquinone formation of D-amino-acid oxidase by irradiation.


Characteristics of the cysteinesulfinate-forming enzyme system in rat liver.


The burst in ATP synthesis observed on addition of ADP to mitochondria.


Developmental patterns and specificities of alkaline phosphatase in the embryonic chick limb.


The effect of nicotinamide adenine dinucleotide on lipolysis in adipose tissue in vitro.


Action of eledosin on isolated vascular strips.


The interaction of pyridoxal phosphate with tyrosine analogs.


Antispasmodic ortho-substituted phenoxyalkylamines.


5-hydroxytryptamine participation in vagal relaxation of the stomach.


Effects of oxygen tension on vascular and other smooth muscle. 1. The resting tension of various isolated intestinal and vascular smooth muscle preparations varied directly with the P(O) (2) of the stream of blood used to bathe them.2. This effect was also obtained when artificial salt solution was used and was therefore not due to circulating hormones.3. The effect could not be antagonized by specific pharmacological antagonists such as hyoscine, phenoxybenzamine, hexamethonium, bromolysergic acid, diethylamide or mepyramine.4. The reactions of the isolated organs to catecholamines and 5-hydroxytryptamine (5-HT) were increased by the higher P(O) (2).5. These results support the view that oxygen tension may play a major role in autoregulation of blood flow.


Structured personality tests and dissimulation.


Effects of sodium extrusion and local anaesthetics on muscle membrane resistance and potential. 1. Membrane potentials and resistances of K-depleted muscles were measured in the cold and again after warming in K-containing media so that active ion movements occurred.2. On warming there was a fall of resistance and a gradual rise of potential which passed through a maximum. Later measurements of resistance in a chloride medium showed that values were, if anything, higher than initially in the warm.3. The excess potentials measured approximated to those required to induce passive inward movement of the K ions through the measured K resistance.4. Permeabilities for K(+) and Cl(-) were deduced. When cocaine, procaine, amytal or mepyramine were added or when K(+) was replaced by Rb(+) in the Cl(-)-free solution the K(+) permeability was eventually reduced. The same agents led to an enhanced initial response of potential to warming, but later the potentials in Cl(-)-free media fell to less than the K(+) equilibrium values.5. A method for obtaining the resistivity of the membrane from measurements made in conditions of non-linear voltage-current dependence was applied.


The rise in clotting factor 8 induced in man by adrenaline: effect of alpha- and beta-blockers. 1. Human subjects received intravenous infusions of adrenaline preceded by saline, phentolamine (an alpha-blocker) or either pronethalol or propranalol (beta-blockers), in different experiments.2. Clinical measurements of blood pressure and pulse rate confirmed that alpha- or beta-blockade had been achieved.3. The rise in clotting factor VIII induced by adrenaline was blocked by pronethalol and propranalol but not by phentolamine. This indicated that the effect of adrenaline on factor VIII was mediated by beta-receptors.


Waste management and personal hygiene under controlled environmental conditions.


Modification by guanethidine and nethalide of the pressor effects of bradykinin in the rat.


Norepinephrine induced reflex vasodilation and vascular effects of serotonin.


The effect of reserpine and syrosingopine upon pentobarbital depression.


An isotopic assay for dihydrofolate reductase.


Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes.


Comparative reduction of nitrate by spinach nitrate reductase with NADH2 and NADPH2.


Regulation of citrate synthase activity in escherichia coli.


Analysis of 3-alpha-and 3-beta-hydroxysteroid oxidoreductases of rat liver by disc electrophoresis.


Accelerated crystal growth of sulphathiazole by temperature cycling.


Amino acid oxidase activity in renal glomeruli and tubular epithelial cells.


A calcium requirement for release of 3H-guanethidine by sympathetic nerve stimulation.


Identification of the thiazide diuretic drugs.


Metal binding tendencies of various antibiotics.


The antifungal activity of some thiocyanatoaniline derivatives.


A comparison of aralkylamines and aralkylguanidines as antagonists of adrenergic neurone blockade.


Evidence for a persistent central depressant action seen after recovery from anaesthesia.


A note on the effects of some psychotropic drugs on the aggressive behaviour in the ant, Formica rufa.


Recovery of noradrenaline levels after reserpine compared with the life-span of amine storage granules in rat and rabbit.


Diethyldithiocarbamate and amphetamine stereotype behavior.


Uptake of tritiated tyramine and (+) amphetamine by mouse heart slices.


Bowel 5-hydroxytryptamine levels in the immunosympathectomised mouse.


Reserpine and the neuromuscular junction.


Pargyline on blood pressure in spinal and decerebrate cats.


Two different mechanisms for incorporation of 3H-metaraminol into the amine-storing granules.


The relation between vanilyl mandelic acid and 5-hydroxyindoleacetic acid excretion in a patient with a carcinoid tumour.


On the neurotoxic effects induced by alkylating agents.


Liberation of noradrenaline from the dog spleen.


The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.


The histochemical localization of 20alpha-hydroxysteroid-dehydrogenase activity in the human placenta and its significance to the foetal placental circulation of gestagens.


The action of trypsin on blockade by 2-halogenoalkylamines: speculation on the nature of the alpha receptor for catecholamine.


The effect of 5-hydroxytryptamine on the human ileum and colon in vitro.


The tricarboxylic acid cycle, the glyoxylate cycle, and the enzymes of glucose oxidation in Pseudomonas aeruginosa.


The role of interstitial cells in the maintenance of Hydra. IV. Migration of interstitial cells in homografts and heterografts.


Influence of monovalent cations on the growth of Hydra littoralis.


Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrin.


The effects of polyoxyethylene compounds on the hydrolysis of chlorbutol.


The effect of isoprenaline on the contraction of smooth muscle produced by histamine, acetylcholine or other agents.


Effect of metal ions on the lysis of yeast cells by cationic dyes and surfactants.


Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents.


Neuromuscular blocking agents: branched-chain tetra-onium compounds.


Ionisation constants and partition coefficients of some analgesically active 2-benzylbenzimidazole derivatives and related compounds.


Lack of effect of yeast RNA upon two types of conditioning.


Methixene: a non-competitive antagonist of bradykinin.


Effect of solanaceous alkaloids on the 5-hydroxytryptamine content of rat brain.


The stimulation of beta-adrenergic receptors by macusine B.


Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.


The effects of morphine, pethidine and nalorphine on the isolated frog skin preparation.


Evaluation of conjunctival and nasal bacterial cultures before intra-ocular operations.


Osteochondritis dissecans with associated malformations in two brothers. A review of familial aspects.


Undergraduate dental school curriculum: dental radiology.


Deafness due to orally administered neomycin.


Effect of CO2 and HCN on the quinone Hill reaction with Anabaena variabilis.


Histological changes of the scrotal testis in unilateral cryptorchidism.


Studies on the bioluminescence of Renilla reniformis. VI. Some chemical properties and the tentative partial structure of luciferin.


Role of adrenergic and cholinergic structures in the control of the pituitary-adrenal system.


Biosynthesis of gibberellins. 3. The conversion of (-)-kaurene to (-)-kauren-19-oic acid in endosperm of Echinocystis macrocarpa Greene.


Natural occurrence and enzymatic synthesis of alpha-nicotinamide adenine dinucleotide phosphate.


The response of human skin to long-term space flight electrodes.


The sympathetic nervous system as a homeostatic mechanism. I. Absolute need for sympathetic nervous function in body temperature maintenance of cold-exposed rats.


Mechanisms of sympathomimetic effects of dichloroisoproterenol: comparison with tyramine, nicotine and norepinephrine.


The negative inotropic action of ephedrine and its modification by various agents.


The influence of sympathetic nervous activity on cardiac catecholamine levels.


A new anorexic agent, WY-5244: cardiovascular actions and influence on sympathomimetic amines.


Effect of monoamine oxidase inhibition on biliary excretion of metabolites of norepinephrine by isolated rat liver.


Premedication: an aid in obtaining accurate complete denture impressions.


Mechanism of radiation-induced granulocytosis.


Inhibitors of microsomal oxidations in insect homogenates. 1. Homogenates of insect tissues were assayed for enzymes capable of oxidizing p-nitrotoluene to p-nitrobenzoic acid. 2. Locust fat-body homogenate 10000g supernatant was an effective enzyme and required no added cofactors. 3. Homogenates of other insects or locust organs and 10000g sediment from locust fat-body were not active and inhibited microsomal oxidations carried out by locust fat-body or rabbit liver enzyme. 4. Inhibitory power was high in homogenates of whole flies and of fly heads or thoraces. 5. Inhibition appeared to involve both irreversible inactivation of enzyme and the removal of essential cofactors.


Retrograde amnesic effects of diethyl ether and bis(trifluoroethyl) ether.


State compensation laws for dental and jaw injuries.


Pathology of Laurence-Moon-Bardet-Biedl syndrome.


Cholinergic-anticholinergic antagonism in parkinsonism.


Enzymic processes in vascular permeability and fragility changes in the skin radiation reaction.


Modifications of the terminal circulation induced by beta adrenergic blockade in normal and coronaropathic subjects.


The effect of glyceraldehyde on glucose metabolism in ehrlich ascites tumor cells.


Indoklon and metrazol convulsions in epileptic and control monkeys.


The relationship between nutrition and androgenic activity in pubescent twin calves, and the effect of orchitis.


Inhibitory effect of salicylates and cinchophen derivatives on amino-acid incorporation.


Self-reports of male alcoholics. A dimensional analysis of certain differences from nonalcoholic male psychiatric outpatients.


Studies on postnatal testicular changes, semen quality, and anomalies of reproductive organs in the mink. A clinical, histological, and histochemical study.


Methodological problems in programmed composition of psychological test reports.


Histochemical studies on the human testes, especially on the interstitial cells of Leydig.


Host-parasite relationships of acarine parasites and their vertebrate hosts. I. The lesions produced by Bakerocoptes cynopteris in the skin of Cynopterus brachyotis.


Variability of Western equine encephalomyelitis virus. I. Genetic markers of virus variants obtained by formaldehyde treatment and ultraviolet irradiation.


Self-limiting infection with herpes simplex virus in cell culture.


A survey of biographical and psychological features in extraordinary fatness.


The effect of monovalent cations on the thermostability of viruses of the tick-borne encephalitis complex.


Morphological study of cultured cells from trypsinized chick embryo tissues, uninfected and infected with tick-borne encephalitis virus.


Variability of Western equine encephalomyelitis virus. II. Pathogenicity of apathogenic and pathogenic virus variants.


Onset and possible site of rabies virus ribonucleic acid synthesis in the cell.


Study of autointerference of influenza virus A (strain WSN).


Alteration of the Newcastle disease virus particle after treatment with pronase of caseinase C.


Inactivation of Bacillus subtilis bacteriophages by hydroxylamine.


Serological survey concerning the presence of influenza haemagglutination inhibitors in normal dog sera.


Fine structure of Rickettsia prowazeki in the haemocytes of ticks Hyalomma dromedarii.


Morphologyof purified tick-borne encephalitis virus.


Measles virus reproduction at suboptimal temperature.


The pharmacology of (minus)-3-hydroxy-N-cyclopropylmethylmorphinan (cyclorphan).


On the central muscle relaxant activity of D.C.I., nethalide and propranolol.


The effect of hemicholinium and triethylcholine on the peristaltic activity of the isolated guinea-pig ileum.


Contribution to the question of specifity of the adrenergic lipomobilization.


Local cholinergic-adrenergic interaction in the dog salivary gland preparation.


Desensitization of the allosteric sites of glutamate dehydrogenase by fluorodinitrobenzene.


Nicotinamide-adenine dinucleotide phosphate enzymes in the mosquito during growth and aging. 1. Optimum conditions were established for determining the activities of the NADP(+)-linked enzymes, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase, in mosquito tissues. 2. The activity of each dehydrogenase was determined in samples of mosquitoes of different ages throughout the life-span. The specific-activity curves attained maximal values in the pupal or early adult period. From these maxima an 81% decrease in glucose 6-phosphate-dehydrogenase and 67% decrease in 6-phosphogluconate-dehydrogenase activities occurred after the tenth day of adult life; a 77% decrease in isocitrate-dehydrogenase activity occurred before the fifth day. 3. The activity differences were found in different body regions as well as in whole organisms. 4. Starvation of the larva or adult did not result in decreases in enzyme activity. 5. These findings support the hypothesis that the activities of enzymes that form NADPH are related to the biosynthetic activity, for the enzyme activities increased during the period of cellular growth and decreased during the aging period.


Biochemical effects of the methyl ester of streptonigrin.


Effects of physostigmine on smooth muscle.


Some properties and mechanism of action of the beta-hydroxy-beta-methylglutaryl coenzyme A reductase of yeast.


The 11-beta-hydroxylation of progesterone and deoxycorticosterone by rat adrenal mitochondria.


Cyclic voltammetry of the pyridine nucleotides and a series of nicotinamide model compounds.


Measurement of the activity of the hexose monophosphate pathway of glucose metabolism with the use of [18O]glucose. Variations in its activity in Escherichia coli with growth conditions.


Isolation and characterization of the N-methyl derivatives of 2-aminoethylphosphonic acid from the sea anemone, Anthopleura xanthogrammica.


In vitro conversion of sepiapterin to isosepiapterin via dihydrobiopterin.


A proposed mechanism for the inactivation of atopic allergens in dilute solution.


Aggregation of certain medicinal amines in aqueous solutions of their salts.


The effect of E. coli endotoxins upon the fluorescein permeability of the blood-aqueous humour barrier.


Ion-exchange separation and ultraviolet  determination of phenylephrine, codeine, and selected antihistamines.


Inhibition of the extraneuronal metabolism of noradrenaline in the isolated heart by adrenergic blocking agents.


Tremorigenic and convulsant actions of intracerebrally administered vegetative poisons in the mouse.


Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds.


Analgesically active basic anilides: stereospecificity and structure of the basic group.


The metabolism of ethionamide and its sulphoxide.


An in vitro model for soluble drug absorption.


Enzymatic decyanation of cyanocobalamin in rat tissues.


A note on spectrophotometric methods for the determination of norethynodrel and mestranol in tablets.


Pharmacological properties of tetrahydropapaveroline.


Some pharmacological effects and chemical properties of N-propargylnoratropine.


Inhibition of the dual amine uptake-concentration mechanisms of the adrenergic neurons by epsilon-aminocaproic acid.


Effects of inhibition and induction of the liver microsomal enzyme system on the narcotic activity of ethanol in mice.


Histamine liberators and melanophores of Rana tigrina.


Beta-adrenergic auto-inhibition of the effect of noradrenaline on avian pulmonary artery.


Effect of desipramine and reserpine on the in vivo beta-hydroxylation of alpha-methyl-m-tyramine and alpha-methyldopamine.


Antihypertensive effect of methyldopa in metacorticoid immunosympathectomized rats.


Similar pharmacological properties of ergometrine and methysergide.


The action of commercial preparations of oxytocin and vasopressin on the smooth muscle of the gut.


Drug retention by the isolated diaphragm preparation.


The effect of purgative drugs on the intestinal absorption of glucose.


Effects of ACTH and TPNH on progesterone-4-14C metabolism in the adrenal gland of the Mongolian gerbil.


Disulfiram and the effect of catecholamines on neuroleptic-induced catalepsy in mice and rats.


Potentiation of catecholamines by a new diphenylalkanolamine. I. Studies in vivo and general pharmacology.


Conversion of 17-alpha-hydroxypregnenolone to dehydroepiandrosterone by adrenal homogenates of immature and adult guinea pigs.


Partial purification of rat liver D-arabinose dehydrogenase.


Clinical studies on the EEG-activating effects of a new central stimulant, sodium-beta, beta-pentamethylene-gamma-hydroxybutyrate.


A new computerized method for the fully automated printout of MMPI graphic profiles.


An evaluation of MMPI scoring accuracy by two national scoring agencies.


Analysis of attitudinal and personality variables in relation to a programmed course in psychiatry.


MMPI F scale as an indicator of severity of psychopathology.


Differentiation of types of college misconduct offenses with MMPI subscales.


Epidemiology and control of bancroftian filariasis in Ceylon.


State health manpower conference.

State health manpower conference.


A.D.A. Conference on Dental Laboratory Relations.


Surfing: another etiological factor in injuries to teeth.


Conference speakers cite problems facing dentistry.


Secondary activation effects of mitochondrial isocitrate dehydrogenases from yeast.


Investigation of the conformation of D-glyceraldehyde-3-phosphate dehydrogenase.


The crystallization and properties of glyceraldehyde-3-phosphate dehydrogenase isolated from rabbit muscle by a simplified procedure.


Investigation of the conformation of lactate dehydrogenase and of its catalytic activity.


A radiochemical enzymatic activity assay for glycerol kinase and hexokinase.


California group arboviruses: immunodiffusion studies.


A sociocultural theory of appropriate sexual role identification and level of personal adjustment.


Effect of psychopathology on group consensus and cooperative choice in a six-person game.


Attraction and similarity of personality characteristics.


Failure of magnesium pemoline to enhance acquisition of the avoidance response in mice.


Paediatric education in the Western Pacific Region.


Effects of medical education on anxiety in students.


Rapid screening assays for soluble and particulate bacterial dehydrogenases.


Theory of hypnosis since the first International Congress, 1889.


Bradykinin induced bronchoconstriction in guinea pigs and its modification by various agents.


Effects of pronethalol on the cardiac action and the lethal dose of strospeside in open-chest dogs.


The quantitative regulation of specific proteins in animal tissues; words and facts.


Effects of various drugs on the bronchoconstriction produced by transmural stimulation of the perfused guinea pig lung.


Release of catecholamines in the guinea-pig by substances involved in anaphylaxis.


Synthesis and pharmacological properties of new 9,10-dihydro-9,10-ethanoanthracene derivatives.


Clinical experience gained in the treatment of advanced genital cancer by the application of the MBBA preparation.


Suppression of the early inflammatory response in the sheep by strophanthin G.


Effect of hemicholinium on the morphology of the developing chick embryo.


The peripheral vascular effects of propranolol and related compounds.


Direct aromatization of C19-steroid sulphates.


Thin-layer chromatography of nucleotides with U.V. transparent plates.


Studies on the regional biosynthesis and metabolism of catecholamines in the central nervous system of the monkey.


A new "antiviral" agent.

A new "antiviral" agent.


Antigens of the oral bacterial flora in the dental pulp.


Track injuries in racing greyhounds.

Track injuries in racing greyhounds.


Thioredoxin. A localized conformational change accompanying reduction of the protein to the sulfhydryl form.


A study of the hemoproteins of thyroid microsomes with emphasis on the thyroid peroxidase.


Biosynthesis of fatty acids in obese mice in vivo. I. Studies with glucose-1-3-H(1-14-C), glucose-6-3-H(6-14-C), DL-lactate-2-3-H(2-14-C), and glycerol-2-3-H(1,3-14-C).


Morphogenetic movements during budding in Hydra.


Serial testing in assessing the effect of meclofenoxate on patients with memory defects.


Tissue dynamics of steady state growth in Hydra littoralis. I. Patterns of cell division.


Adenosine triphosphate-linked control of Pseudomonas aeruginosa glucose-6-phosphate dehydrogenase. Extracts of Pseudomonas aeruginosa (ATCC 7700) cells grown on glucose, gluconate, or glycerol had enzyme activities related to the Entner-Doudoroff pathway. These activities were present in no more than trace amounts when the bacteria were grown on succinate. Fructose-1,6-diphosphate aldolase could not be detected in extracts of the bacteria grown on any of the above carbon sources. Therefore, it appears that P. aeruginosa degrades glucose via an inducible Entner-Doudoroff pathway. The apparent absence of fructose-1,6-diphosphate aldolase in cells growing on succinate suggests that the bacteria can form hexose and pentose phosphates from succinate by an alternate route. d-Glucose-6-phosphate dehydrogenase, a branch-point enzyme of the Entner-Doudoroff pathway, was purified 50-fold from glucose-grown cells. Its molecular weight, estimated by sucrose density gradient centrifugation, was found to be approximately 190,000. The enzyme was strongly inhibited by adenosine triphosphate, guanosine triphosphate, and deoxyguanosine triphosphate, which decreased the apparent binding of glucose-6-phosphate to the enzyme. It is suggested that adenine nucleotide-linked control of glucose-6-phosphate dehydrogenase may regulate the overall catabolism of hexose phosphates and prevent their wasteful degradation under certain conditions requiring gluconeogenesis.


True hermaphroditism discovered 10 years after hypospadias repair: report of 2 cases.


Determination of phenylephrine in combinations with other drugs.


Comparative studies of atrial responses following nicotine and transatrial stimulation.


Modaline and locomotor activity in the mouse.


Pool sizes of metabolic intermediates and their relation to glucose repression of beta-galactosidase synthesis in Escherichia coli. 1. The intermediary metabolism of two strains of Escherichia coli has been examined. One strain (Q22) exhibits acute transient repression of beta-galactosidase synthesis when glucose is supplied to cells growing on glycerol; the other strain (W3110) does not. The two strains do not differ genetically in their lac operons. 2. Strain Q22 uses about twice as much glucose as strain W3110 per unit of cell mass produced. 3. Pentose phosphate-cycle activity in the presence of glucose is much stronger in strain Q22 than in strain W3110. 4. In strain Q22 the pool sizes of glucose 6-phosphate, 6-phosphogluconate, fructose 1,6-diphosphate and NADPH increase when glucose is added to cells growing on glycerol, and beta-galactosidase synthesis is severely inhibited. After about 1hr. the synthesis of beta-galactosidase is partly resumed, and the pool sizes of the four compounds fall. ATP, NADH and several other phosphorylated compounds show no concentration changes. 5. These concentration changes do not occur in strain W3110, in which beta-galactosidase synthesis is only rather weakly repressed by glucose. 6. It is suggested that repression of enzyme synthesis by glucose requires the rapid operation of the pentose phosphate cycle, and is mediated by one of the four substances whose concentration rises and later falls in strain Q22. A definite choice of effector from among these four possibilities cannot at present be made.


Fluorimetric determination of D-amino acid oxidase. 1. A sensitive fluorimetric procedure for the assay of d-amino acid oxidase has been developed. 2. The method depends on the formation of a fluorescent derivative, 2-hydroxy-3-methylquinoxaline, on condensation of pyruvate with o-phenylenediamine in acid medium. 3. 2-Hydroxy-3-methylquinoxaline fluoresces strongly in 50% (v/v) sulphuric acid after excitation at 375mmu. A single emission peak is observed at 480mmu. 4. Formation of the quinoxaline is dependent on time, temperature, acidity and relative concentration of reactants. 5. A particulate preparation from mouse kidney required FAD for optimum activity at pH8.5; K(m) was 3.8x10(-3)m; K(FAD) was 1.4x10(-7)m and the reaction was strongly inhibited by p-chloromercuribenzoate and phenylmercuric acetate. 6. Subcellular fractionation on a sucrose density gradient confirmed that the d-amino acid oxidase was localized on small granules.


Address of the president.

Address of the president.


Clinical evaluation of laboratory guidance to antibiotic therapy.


Changes in the enzyme pattern of the mammary gland of the lactating rat after hypophysectomy and weaning. 1. The enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, phosphoglucomutase, UDP-glucose pyrophosphorylase, phosphofructokinase, ATP-citrate lyase and acetyl-CoA carboxylase have been assayed in rat mammary glands in various stages of involution after hypophysectomy and weaning. 2. After hypophysectomy all seven enzymes decline in activity over a 12-16hr. period but the extent of the decline varies, with acetyl-CoA carboxylase becoming almost totally inactive, ATP-citrate lyase and phosphofructokinase showing a large decrease, and the remaining enzymes a less marked decline. 3. Within 24hr. of removing the litter a change in the pattern of enzyme activity is found very similar to that after hypophysectomy. 4. The significance of these results is discussed in relation to the endocrine control of mammary gland metabolism and the mechanisms of involution.


An interaction between tremorine and various autonomic agents on cardiac norepinephrine in the rat.


Atropine-like properties of hemicholinium-3.


Stimulation of 11-beta-hydroxylation in rat adrenal homogenates following inhibition of the respiratory chain by cyanide.


Prospective and retrospective psychological studies of coronary heart disease.


Studies on interstitial cells in tissue culture: steroid biosynthesis in monolayers of mouse testicular interstitial cells.


Surgical problems and treatment of foot lesions associated with diabetes mellitus.


Cytochemical demonstration of glutathione reductase (EC 1.6.4.2) in Saccharomyces cerevisiae.


Effects of gastrin and its analogues on isolated smooth muscles.


Congenital malformations in nonhuman primates: spontaneous and experimentally induced.


Substrate transformations dependent on respiratory states of mitochondria. Changes in metabolic control sites of rabbit heart mitochondria.


Oxidation of reduced triphosphopyridine nucleotide by pyridinium salts.


A histochemical study of the human odontoblast.


Preparation of starch gel zymograms: peroxide-producing enzymes and ceruloplasmin.


Personality and obsessional neurosis.

Personality and obsessional neurosis.


Citrate synthase interaction with polyphosphate derivatives.


A short scale for the assessment of mental health in the community aged.


Gas-liquid chromatographic analysis of sciatic nerves and spinal cords in experimental allergic neuritis.


Morphological and biochemical studies on the storage of serotonin and histamine in blood platelets of the rabbit.


Studies on the mechanism of nidation XXX: selective antihistaminic inhibition of uterine responses in relation to suppression of decidualization.


Dihydrofolate reductase from Trypanosoma equiperdum. I. Isolation, partial purification, and properties.


The Hastings Fluoridation Project V. Dental effects between 1954 and 1964.


Do we have too many dental meetings?

Do we have too many dental meetings?


The effect of fluoridation on a Dental Public Health Programme.


A solidifiable formic acid-PVA solution for transporting, preserving and mounting mosquito larvae and pupae.


Advances in large-animal surgery.

Advances in large-animal surgery.


Participation of the lysine pathway in dipicolinic acid synthesis in Bacillus cereus T.


The role of C-type cytochrome in the Hill reaction with Euglena chloroplasts.