Continuous trophic influence of chromatolysed gustatory neurons on taste buds.


An attitude scale for dental health.

An attitude scale for dental health.


Occurrence of inducible and NAD(P)-independent primary alcohol dehydrogenases in an alkane-oxidizing Pseudomonas.


Cytotoxic effects of lymphoid cells in vitro.


The effect of cesium-137 gamma rays on regeneration in tubularia.


Reconstitution of a fatty acid omega-hydroxylation system by a solubilized kidney microsomal preparation, ferredoxin, and ferredoxin-NADP reductase.


Acute respiratory failure in chronic obstructive pulmonary disease. II. Treatment.


Adenosine 3',5'-monophosphate as the mediator of ACTH-induced ascorbic acid depletion in the rat adrenal.


Effect of anterior pituitary perfusion and intraventricular injection of catecholamines and indoleamines on LH release.


Early effects of experimental cryptorchidism on the activity of selected enzymes in rat testes.


Assessment of behavioural effect of drug therapy by the use of personality testing.


Reduction of the delta-4-3-ketosteroids by normal and hypertensive rat liver.


The antagonism of the effects of L-3,4-dihydroxyphenylalanine of spinal reflexes by adrenergic blocking agents.


The clock of the malaria parasite.

The clock of the malaria parasite.


ECG telemetry within a small, closed chamber.


Erythropoietic activity of steroid metabolites in mice. The per cent Fe(59) incorporation into circulating erythrocytes as an indicator for new hemoglobin production was used in the polycythemic exhypoxic mouse system to study the effects of certain steroid hormone metabolites on erythropiesis. Enhanced Fe(59) incorporation was observed after the administration of several metabolites with a 5beta-H configuration, while those with a 5alpha-H configuration had no stimulatory effect. The stimulatory effect in avian systems has been shown by others to be due to an increased activity of delta-aminolevulinic acid synthetase, the limiting enzyme in heme biosynthesis. These in vivo studies thus indicate that in this mouse system, as in previously reported studies with avian and human bone marrow cells, some steroid metabolites stimulate hemoglobin synthesis. The observation that the same structure-junction relationship exists in the currently described system as in the avian suggests that these steroids probably induce delta-aminolevulinic acid synthetase in the mouse. The erythropoietic action of these nonandrogenic steroid metabolites may prove to be clinically useful.


Cardiac output under anaesthesia.

Cardiac output under anaesthesia.


The action of beta adrenergic site stimulating catecholamines on isolated frog skin.


Adrenergic receptors in human veins.

Adrenergic receptors in human veins.


Clinical allergies in cattle.

Clinical allergies in cattle.


Vaginal surgery for non-malignant gynecological conditions.


A diphtheria outbreak in Chicago.

A diphtheria outbreak in Chicago.


Pelvic trauma.

Pelvic trauma.


Therapy for AHF and PTC hemophilia. I.

Therapy for AHF and PTC hemophilia. I.


Medical services in South Africa.

Medical services in South Africa.


Sex chromosome abnormalities and neuropsychiatric disordeers.


The mechanism of glutamate dehydrogenase reaction. 3. The binding of ligands at multiple subsites and resulting kinetic effects.


L-Dopa therapy in Parkinson's disease.

L-Dopa therapy in Parkinson's disease.


Extra pulmonary abscesses due to Diplococcus pneumoniae.


Dermatologic implications of immunological unresponsiveness.


The relation between the uptake of cetyltrimethylammonium bromide by Escherichia coli and its effects on cell growth and viability.


Hypothalamic beta-adrenergic "satiety" system antagonizes an alpha-adrenergic "hunger" system in the rat.


A comparative study of two alcoholic groups and a control group.


On the correlation between enzyme induction, anti-inflammatory and thymolytic activity in a fast-acting and long-acting betamethasone ester.


Painful cutaneous lesions of the feet.

Painful cutaneous lesions of the feet.


A biochemical-cellular-morphological explanation for antiulcerogenic effects of parasympatholytics and of surgical vagotomy in Shay rats.


On the mechanism of hormone action. 18. Alterations of the nature of RNA synthesized in isolated fat body cell nuclei as a result of ecdysone and juvenile hormone action.


Isolation of a ribosome-dependent guanosine triphosphatase from yeast.


Complexes of chromium with beta-glycerophosphate: their nature and properties.


Molecular orbital calculations of the acid-catalysed hydrogen exchange in substituted thiophenes.


Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activity in adrenals of mice with spontaneous adrenocortical lipid depletion. A comparison with C57B1 mice.


Cycles of jungle malaria in West Malaysia.


Production of antibiotics by Epidermophyton floccosum. 4. The antibacterial activity of the "Epidermophyton factor" (EPF) compared with that of some steroid antibiotics.


Cache Valley virus in the Del Mar Va Peninsula. I. Virologic and serologic evidence of infection.


Cache Valley virus in the Del Mar Va Peninsula. II. Identity of virus recovered from mosquitoes.


Cache Valley virus in the Del Mar Va Peninsula. IV. Biological transmission of the virus by Aedes sollicitans and Aedes taeniorhynchus.


Arbovirus isolations from mosquitoes collected in central Utah in 1967.


Cardiac pharmacology.

Cardiac pharmacology.


Aerospace problems in pharmacology and toxicology.


Buttonwillow virus, a new Arbovirus isolated from mammals and Culicoides midges in Kern County, California.


The metabolic alteration of drugs.

The metabolic alteration of drugs.


Disulfide reduction in rat liver. I. Evidence for the presence of nonspecific nucleotide-dependent disulfide reductase and GSH-disulfide transhydrogenase activities in the high-speed supernatant fraction.


Increased release of dopane from striatal dopaminergic terminals in the rat after treatment with a neuroleptic: thioproperazine.


Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro.


An experimental method for demonstrating the gastric antrum and its clinical application.


Independence of antimineralocorticoid and catatoxic effects of various steroids. A series of unrelated steroids were tested for antimineralocorticoid activity by Kagawa's test in male rats and by modified test in female rats.  Adrenalectomized male rats given 12 mcg desoxycorticosterone (DOC) and 2.5 ml normal saline received 1 mg of the test steroid, and their urine was analyzed for sodium and potassium.  Results were expressed as the ratio (log sodium x 10)/potassium, and the end point was reversal of the DOC mineralocorticoid effect, i.e., increasing the ratio lowered by DOC.  As expected, spironolactone and SC-11927 reversed DOC, but ethylestrenol, norbolethone, progesterone, triamcinolone, and prednisolone lowered the ratio as much as, or more than, DOC.  In female rats given 10 mg of test steroids for 3 days, qualitatively similar results were obtained.  These results showed that antimineralocorticoid activity is not associated with catatoxic (i.e., hepatic drug metabolizing) activity in spironolactone, norbolethone, progesterone, or ethylestrenol.


The cholesterol side-chain cleavage enzymes in steroid hormone-producing tissues.


Antibrillatory effect of some beta-adrenergic receptor blocking agents determined by a new test procedure in mice.


The effect of blue light on some flavin enzymes.


Tektite-I program: aerobiological aspects.


The effect of beta-adrenergic receptor blocking agents on drug-induced insulin secretion.


Tektite-I program: bacteriological aspects.


Heat stress in the cockpit of the AH-1G hueycobra helicopter.


Motion sickness in USAF flying personnel.


Treatment of secondary disease in leukaemic mice with host-type and third-party haemopoietic cells and blood.


Adaptation of albumin density gradient centrifugation to human bone marrow fractionation.


Report on the 10-year dental findings in the Lower Hutt fluoridation project.


The immunogenicity of brain, ovary, and skin allografts in mice.


A test to measure the immunosuppressive potency of antilymphocyte sera.


Electron microscope study on the development of Uukuniemi virus.


Electrophoretic studies with L cell interferon in polyacrylamide gels.


Microplaque titration of pseudorabies virus by immunofluorescence.


Susceptibility of rabbit kidney cell cultures to Egyptian strains of tick-borne viruses.


Some biological properties of Uukuniemi virus, strain Poteplí-63.


The relation of caries experience to fasting and postprandial serum glucose levels.


Isolation in Southern France and characterization of new tick-borne viruses related to Uukuniemi: Grand Arbaud and Ponteves.


Uukuniemi virus in small rodents.

Uukuniemi virus in small rodents.


Strategic conventioneering.

Strategic conventioneering.


Release of an interferon-like virus inhibitor during contact of mouse leukocytes with target cells.


Some physical and chemical properties of Uukuniemi virus, strain Poteplí-63.


Purification, characterization, and structural studies of influenza A2 virus components.


Further studies on plant valine dehydrogenase.


Characterization of Neurospora crassa mitochondria prepared with a grind-mill.


Graft-versus-host reactions in nonirradiated mice. Early suppression of Jerne Plaques and Hemopoietic colony-forming units.


Measurement of graft-versus-host reactions on the chorioallantoic membrane of the chicken.


DNA-membrane complex: macromolecular content and stimulation of enzymatic activity by polyadenylic acid. A DNA-cell membrane complex has been isolated from cell suspensions of virulent pneumococci by sarcosyl lysis followed by centrifugation on a sucrose gradient. When polyadenylic acid plus the eight naturally occurring deoxyribonucleosides and deoxyribonucleotides are added to cell suspensions, the percentage of total DNA in the complex increases with incubation time. This increase is not observed in unsupplemented cell suspensions. However, the percentages of RNA, protein, and phospholipid do not increase with incubation time in either supplemented or control complexes. A variety of deoxyribonucleotide kinases and the DNA polymerase are also detected in the DNA-membrane complex, and their specific activities are greater in complexes extracted from supplemented cell suspensions than in those extracted from controls.


Nonmedical drug use among college student psychiatric patients.


Role of the spleen in experimental neonatal infections and transplantation.


Lower urinary tract problems related to infection: diagnosis and treatment.


The diuretic activity of tetrahydroaminacrin in rats.


A Mexican case of mycetoma caused by Streptomyces somaliensis.


A delayed cutaneous reaction following contact with jellyfish.


Excretion of radiocesium (137Cs) in sweat from humans.


Negative results of attempts to prolong the effect of phospholipids (PL) and cholesterol (Chol) on the formation fo tumours induced by 3-methyl-cholanthrene (MeC).


Polyribosomes in thin sections of Leishmania donovani.


Pyridine nucleotide transhydrogenase from Azotobacter vinelandii. A method is described for the partial purification of pyridine nucleotide transhydrogenase from Azotobacter vinelandii (ATCC 9104) cells. The most highly purified preparation catalyzes the reduction of 300 mumoles of nicotinamide adenine dinucleotide (NAD(+)) per min per mg of protein under the assay conditions employed. The enzyme catalyzes the reduction of NAD(+), deamino-NAD(+), and thio-NAD(+) with reduced nicotinamide adenine dinucleotide phosphate (NADPH) as hydrogen donor, and the reduction of nicotinamide adenine dinucleotide phosphate (NADP(+)) and thio-NAD(+) with reduced NAD (NADH) as hydrogen donor. The reduction of acetylpyridine AD(+), pyridinealdehyde AD(+), acetylpyridine deamino AD(+), and pyridinealdehydedeamino AD(+) with NADPH as hydrogen donor was not catalyzed. The enzyme catalyzes the transfer of hydrogen more readily from NADPH than from NADH with different hydrogen acceptors. The transfer of hydrogen from NADH to NADP(+) and thio-NAD(+) was markedly stimulated by 2'-adenosine monophosphate (2'-AMP) and inhibited by adenosine diphosphate (ADP), adenosine triphosphate (ATP), and phosphate ions. The transfer of hydrogen from NADPH to NAD(+) was only slightly affected by phosphate ions and 2'-AMP, except at very high concentrations of the latter reagent. In addition, the transfer of hydrogen from NADPH to thio-NAD(+) was only slightly influenced by 2'-AMP, ADP, ATP, and other nucleotides. The kinetics of the transhydrogenase reactions which utilized thio-NAD(+) as hydrogen acceptor and NADH or NADPH as hydrogen donor were studied in some detail. The results suggest that there are distinct binding sites for NADH and NAD(+) and perhaps a third regulator site for NADP(+) or 2'-AMP. The heats of activation for the transhydrogenase reactions were determined. The properties of this enzyme are compared with those of other partially purified transhydrogenases with respect to the regulatory functions of 2'-AMP and other nucleotides on the direction of flow of hydrogen between NAD(+) and NADP(+).


Mevalonate metabolism in supernatant fractions of lysates of Lactobacillus plantarum. The supernatant fractions of lysates of Lactobacillus plantarum metabolize mevalonate into lipids. Adenosine triphosphate and uridine, as well as related compounds, and reduced nicotinamide adenine dinucleotide phosphate or reduced nicotinamide adenine dinucleotide stimulate this process. To obtain very active supernatant fractions, the method of lysis is modified to include polyamines during lysozyme treatment of cells and subsequent shocking with citrate buffer.


Tumors and aging.

Tumors and aging.


Review of tumors and tumor-like conditions in protozoa, coelenterata, platyhelminthes, annelida, sipunculida, and arthropoda, excluding insects.


Anomalies of growth and form in hydra: polarity, gradients, and a neoplasia analog.


Water vapor removal system. AMRL-TR-68-42.


Supernumerary heads in Hydra viridis.

Supernumerary heads in Hydra viridis.


Systems approach to evaluating Hydrogenomonas cultures. NASA CR-1296.


The effect of alkyl substitution in drugs. XXI. Synthesis and a comparative pharmacological study of a number of potential orphenadrine metabolites.


Mast cells in corneal immune reaction.

Mast cells in corneal immune reaction.


Dental caries experience of New Zealand children over a twenty-year period.


International patterns of oral health care--the example of New Zealand.


Antigenic structure of influenza A viruses; an immunodiffusion study.


Kinetics of reaction of rabies virus with specific antibodies in conditions on in vitro virus neutralization test.


Behaviour of Kemerovo group viruses in chicks, chick embryos and chick embryo cell cultures.


Detection by the fluorescent antibody technique of Uukuniemi virus in cell cultures and mouse brain sections.


Experimental pathogenicity of Bhanja virus for white mice and Macaca mulatta monkeys.


Growth of Bhanja virus in tissue culture.


The use of cell cultures for some diagnostic methods with Uukuniemi virus.


Study of the virulence of tick-borne encephalitis virus. XII. Resistance to intracerebral challenge of sheep and swine given the monkey-attenuated virus.


Cytopathic changes characteristic of cytomegalovirus in primary outgrowth of fibroblast cells from a canine kidney culture.


Cultures of kidney cells from wild living small mammals and their use in the study of arboviruses.


Immunogenicity of an attenuated pseudorabies virus in cattle.


The biosynthesis of androst-16-enes in boar testis tissue. 1. The metabolism of [4-(14)C]pregnenolone to androst-16-enes has been studied in short-term incubations of boar testis tissue. With fresh tissue androsta-5,16-dien-3beta-ol (8%) and 5alpha-androst-16-en-3beta-ol (2%) were formed. Tissue that had been stored at -20 degrees C was still capable of metabolizing pregnenolone to androsta-5,16-dien-3beta-ol. 2. NADPH was essential for the formation of androsta-5,16-dien-3beta-ol from pregnenolone; NADH had less activity and ATP was not necessary for the reaction. 3. [4-(14)C]Androsta-5,16-dien-3beta-ol, prepared biosynthetically from [4-(14)C]pregnenolone, was shown to be converted by boar testis preparations into androsta-4,16-dien-3-one (31%) if NAD(+) was present or into 5alpha-androst-16-en-3beta-ol (4%) if NADPH was present. 4. 17alpha-Hydroxyandrost-4-en-3-one and 3beta,17alpha-dihydroxypregn-5-en-20-one were considered as possible precursors for androst-16-ene formation, but both were shown to be ineffective. 5. No radioactivity was incorporated into androst-5-en-3beta-ol used to trap any corresponding (14)C-labelled compound formed from [4-(14)C]pregnenolone.


Hepatic drug-metabolizing enzyme activity in rats pretreated with (-)-emetine or (plus or minus)-2,3-dehydroemetine. 1. Pretreatment of female rats with (-)-emetine or (+/-)-2,3-dehydroemetine (at 18mumol/kg body wt. for 24h) prolongs the hexobarbital-induced sleeping-time of the treated animals. 2. This effect is not observed on pretreating animals with other compounds closely related to (-)-emetine, such as (-)-isoemetine or (+)-O-methylpsychotrine. 3. Liver microsomal drug-metabolizing enzyme activity in vitro as measured by N-demethylation of aminopyrine and azo-reduction of Neoprontosil is inhibited in rats pretreated with (-)-emetine or with (+/-)-2,3-dehydroemetine. 4. These inhibitory effects on drug metabolism in vitro are not observed in corresponding experiments involving pretreatment of rats with (-)-isoemetine or (+)-O-methylpsychotrine. 5. Co-administration of emetine or 2,3-dehydroemetine and sodium phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane to rats abolishes or greatly diminishes the stimulation of drug-metabolizing enzyme activity in vitro usually obtained by the administration of phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane alone. 6. Further, in rats pretreated with sodium phenobarbital and subsequently injected with emetine or 2,3-dehydroemetine the pre-stimulated drug-metabolizing enzyme activity in vitro is diminished. 7. The inhibitory effects on drug-metabolizing enzyme activity after pretreatment with (-)-emetine or (+/-)-2,3-dehydroemetine do not appear to be related to NADPH generation.


Evaluation of compounds for insecticidal activity on adult mosquitos. 1. Responses of adult mosquitos to some new insecticides. Responses shown by female mosquitos to topical applications of solutions, to deposits from water-dispersible-powder formulations, or to exposure to the vapour from such deposits, are described for a number of compounds that have shown promise as residual contact insecticides.The behaviour of Anopheles stephensi females in laboratory tests indicates that departures of mosquitos from treated buildings, and their survival rates, are likely to be increased as a result of irritation and consequent activity after only a brief period of contact with phthalthrin (OMS-1011) and other synthetic pyrethroids but not with dieldrin (OMS-18) and lindane (OMS-17) or the carbamates and organophosphorus compounds tested. Mosquitos were not disturbed by exposure to the vapour from deposits of any of the compounds.The rates of action of the different compounds following their application in solution directly to the insect cuticle or contact of the mosquitos with deposits on plywood and plaster emphasize the importance of the lipid-solubility and partitioning properties of an insecticide in determining its passage from a surface deposit into, and through, the cuticle to the site of action.


Evaluation of compounds for insecticidal activity on adult mosquitos. 2. Toxicity to adult mosquitos and the physical properties of some new carbamates. The N,N-dimethylcarbamates are much less toxic and much more volatile than the corresponding N-methylcarbamates. N-acylation of N-methylcarbamates is also generally accompanied by a loss in intrinsic toxicity to adult mosquitos by topical application, but the reduction in toxicity may be relatively small and in some N-acetyl derivatives may not occur at all. N-acylation is also accompanied by changes in physical properties such as lipid solubility and partition coefficient, which influence contact toxicity, and volatility, which affects residual activity. In the series of compounds examined, contact toxicity is maximal in the N-acetyl derivatives but their volatility is often so high that they lack the persistence required of residual insecticides. This does not apply, however, to the N-acetyl derivatives of OMS-597 and OMS-708 because the volatility of the parent compound is so low that some degree of persistence can be sacrificed to obtain some improvement in contact activity.OMS-1064 is the only N-chloroacetyl derivative tested so far that shows promise as a residual insecticide.


Evaluation of compounds for insecticidal activity on adult mosquitos. 3. Properties of some N-methylthiolcarbamates. N-methylcarbamates derived from thiophenols possess negligible insecticidal activity against the mosquitos Anopheles stephensi and Aedes aegypti. The probable basic reason for the inactivity is that these compounds are much less efficient inhibitors of cholinesterase than the oxygen analogues.


Evaluation of compounds for insecticidal activity on adult mosquitos. 4. Insecticidal activity and physical properties of some halogenated organophosphorus esters. The effects of changes in structure upon toxicity to adult mosquitos and upon physical properties which are important in determining contact effectiveness and residual activity are described for a group of O,O-dialkyl O-halogenated-phenyl phosphates, phosphorothionates and phosphamido(thio)ates. This group includes such established insecticides as fenchlorphos, bromophos and iodofenphos.


Evaluation of compounds for insecticidal activity on adult mosquitos. 5. Toxicity to adult mosquitos and residual properties of some pyrethroids. New pyrethrin-like compounds are compared with earlier synthetic pyrethroids and natural pyrethrins for intrinsic toxicity to adult mosquitos and for residual contact activity. Two of the compounds are at least as toxic as pyrethrin I to female Anopheles stephensi and Aedes aegypti. Residues of these compounds are very persistent in the dark or in very subdued lighting but they decompose on exposure to normal intensities of daylight and rapidly lose their insecticidal activity.


Plasmodium ovale malaria acquired in Viet-Nam. Four cases of Plasmodium ovale malaria are reported among US servicemen stationed in Viet-Nam between January 1966 and March 1969. Taken together with other cases cited by the authors, these provide strong evidence of the existence (sometimes disputed) of this Plasmodium in continental South-East Asia.None of the men had served in any other area of endemic malaria and their travel and medical histories suggest that all 4 infections were acquired by mosquito transmission. They constitute only 0.066% of the 6036 malaria cases reported among servicemen returning from Viet-Nam during this period and represent only 0.11% of the blood films from 3686 individuals examined at the US National Malaria Repository during the same period.Serological testing for malaria antibodies with the indirect fluorescent technique corroborated the diagnosis of P. ovale in 1 case. Speciation was not possible in the other 3 cases since titres to P. vivax and P. ovale antigens were identical. Only 1 of the patients reported previous experience with vivax malaria.Most of the parasites seen in thin blood films were developing trophozoites and immature schizonts; ring forms and gametocytes were rare; mature schizonts were not found. The morphology of the parasites was typical of P. ovale, with more than 50% of the infected cells showing fimbriations, an oval shape or both.


Nucleic acid homology as a measure of genetic compatibility among streptococci and a strain of Diplococcus pneumoniae.


Effects of a cardio-selective beta-adrenergic blocking agent on the heart and coronary circulation.


Mechanism of decreased myocardial contractile force after epicardiectomy.


Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. The ability of spleen cells from young (3 month) and old (1 yr) NZB mice to induce GVH reactions in newborn C57BL/6N mice was compared quantitatively using the Simonsen spleen assay. Young NZB cells were five times more reactive than cells from older mice. The minimum number of cells producing detectable reactions was 2 x 10(6) for the young and 10 x 10(6) for the old. Young and old cells combined and injected together produced GVH reactions quantitatively similar to those obtained with inocula composed of young cells alone. Mixtures of two cell populations producing no detectable reactions when injected separately into different recipients (1 x 10(6) young cells and 4 x 10(6) old cells) produced reactions approximately equal to those obtained with 5 x 10(6) young cells. As few as 0.25 x 10(6) young cells were sufficient to effect a reaction when combined with 4.75 x 10(6) old unreactive cells. Viability of both cell populations was essential for GVH reactivity. This evidence of synergy in GVH reactions indicates that old NZB spleen cells can be rendered immunologically more reactive in the presence of a normally reactive population.


Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin. The capacity of cells from different lymphoid tissues obtained from Balb/c mice to produce graft-vs.-host (GVH) reactions was quantitatively determined in C57BL/6N by Balb/c F(1) hybrid recipients. Synergistic responses were observed when small numbers of cells from lymphoid tissues that were rich in GVH activity such as spleen and femoral lymph node were combined with weakly reactive thymus cells. Thymus and spleen cells obtained from 1-wk old mice were separately inactive but produced moderate GVH reactions when combined in equal proportions. GVH activity of spleen cells from mice thymectomized at 3 days of age was partially restored by the addition of small numbers of spleen or thymus cells from adult mice. Changes in ratio between the two cell populations markedly affected the degree of synergy. Synergy was not observed when Balb/c cells were combined with Balb/c x C57BL/6N F(1) hybrid cells and inoculated into C57BL/6N recipients, but was demonstrated when Balb/c and C57BL/6N cells were combined and inoculated into F(1) recipients, indicating that a genetic disposition to mount GVH reactions in both populations is required to produce synergy. The data indicate that at least two cell types are necessary for GVH reactions, and that synergy between cell populations results from favorable adjustments in the ratio between these two cell types.


Allogeneic thymus grafts and the restoration of immune function in irradiated thymectomized mice. Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunological capacity of such animals was studied. Thymus homografts which share the same H-2 locus with the CBA mouse were permanently tolerated and immunological restoration was complete. Skin from the thymus donor was specifically retained, but third party skin with even minor (non-H-2) incompatibility was normally rejected and hemolytic plaque-forming cells of the spleen were restored. Thymus homografts which differ at the H-2 locus were promptly rejected and led to accelerated rejection of skin subsequently grafted from the thymus donor. With such H-2 incompatible thymus grafts, third party skin with minor histo-incompatibility was retained while there was slight to moderate restoration of rejection of skin with major (H-2) incompatibility. Graft-vs.-host activity was restored, but there was no return of plaque-forming spleen cells, hemolysins, hemagglutinins, or peripheral lymphocyte counts. In view of the cross-reactivity at the H-2 locus in CBA mice between thymus and third party skin donors, it was felt that restoration of skin rejection and graft-vs.-host activity could be adequately explained on the basis of immunization by the thymus graft and did not require the postulation of true immune restoration or a thymus hormone.


An analysis of the genetic requirements for delayed cutaneous hypersensitivity reactions to transplantation antigens in mice. The experiments reported herein provide ample evidence that mice, like most other mammalian species, are capable of displaying readily observable and reproducible delayed cutaneous hypersensitivity reactions indicative of transplantation immunity. By employing a variety of genetically defined strains, it has been shown that a genetic requirement for the development of a positive normal lymphocyte transfer reaction in mice is a difference between host and cell donor at the H-2 locus. By contrast, the immune lymphocyte transfer reaction consistently reflected the full range of histoincompatibility, both inclusive and exclusive of the H-2. It was incidentally discovered that erythema regularly accompanied delayed cutaneous reactions in the skins of female mice, whereas no local redness accompanied their counterparts in male skins. The influence of cutaneous erythema on the scoring of delayed skin reactions is discussed.


Quantitative studies on the mixed lymphocyte interaction in rats. IV. Immunologic potentiality of the responding cells. Studies were designed to provide some explanation for the unexpectedly large proportion (2%) of parental rat strain peripheral blood lymphocytes that are reactive in the mixed lymphocyte interaction (MLI) to a strong homologous transplantation isoantigen(s) present on cells from an F(1) donor. The possibilities considered involve nonspecific activation and multispecific reactivity on the part of the responding cells. The essential findings of this study were: (a) In 3-way mixed cultures, lymphocytes obtained from tolerant animals were not "recruited" to proliferate in the presence of cells from normal, isologous donors which were in the process of responding to F(1) cells bearing the tolerance-inducing antigens. With the use of chromosome markers and normal and tolerant parental strain donors of different sexes, the responsive cells were identified and proved to be derived from the normal and not the tolerant donor. (b) The magnitude of the proliferative response is increased additively when potentially reactive cells are exposed to two antigen systems simultaneously. On the other hand, doubling the "gene-dosage" of the genetic determinants of the H isoantigens employed had no effect on the responding cells. (c) A state of induced immunologic tolerance to one H isoantigen system did not alter the response capacity of cells from such a donor to an alternative antigen system. (d) Mixed cultures of heterologous cells from human and rat donors displayed a proliferative response which was less than that of homologous mixed cultures from human or rat donors. Prior sensitization of rat donors with human cells, however, greatly increased the mitotic activity of rat lymphocytes stimulated with human cells. These results suggest that the large number of responsive cells in the MLI do not include a significant number recruited or activated in some nonspecific manner. Rather, they appear to be fully specific in their response capacities so that a given lymphocyte does not react to a multiplicity of different antigens. The degree of proliferation depends on the number of different antigen systems presented to the responding population and not on the number of genetic determinants or "gene dosage" of a given isoantigen system. Finally, on a cell-for-cell basis, the peripheral blood lymphocyte population contains more cells reactive to histocompatibility isoantigens within the species than to heterologous antigens of a different species.


Clandestine drug laboratories.

Clandestine drug laboratories.


Mixed-function oxidation.

Mixed-function oxidation.


Fatty acid synthetase from the liver of the plaice, Pleuronectes platessa.


The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. 1. The activity of 20alpha-hydroxy steroid dehydrogenase in rat ovarian corpora lutea increased at least 50-fold between 2 days before and 2 days after parturition, and then fell gradually during lactation. The activity of 3beta-hydroxy Delta(5)-steroid dehydrogenase decreased by 50% at parturition but remained constant at other times. 2. The 20alpha-hydroxypregn-4-en-3-one/progesterone concentration ratio in the ovary fell tenfold between 1 day before and 1 day after parturition, in contrast with the increase of the ratio for these steroids in plasma. 3. Pregnenolone was metabolized in intact cells or cell-free systems either to pregn-5-ene-3beta,20alpha-diol and then to 20alpha-hydroxypregn-4-en-3-one by 20alpha-hydroxy steroid dehydrogenase and 3beta-hydroxy Delta(5)-steroid dehydrogenase respectively, or directly to progesterone by the latter enzyme. The relative activities of these pathways appeared to reflect the relative amounts of the two enzymes and the concentrations of their respective coenzymes NADPH and NAD(+). 4. From these and other observations it was concluded that the cessation of progesterone secretion, which precedes parturition and lactogenesis at the end of pregnancy, is partly due to the redirected metabolism of pregnenolone away from progesterone and towards 20alpha-hydroxypregn-4-en-3-one as the secreted end product. This is primarily the consequence of the sharp increase in the activity of 20alpha-hydroxy steroid dehydrogenase. This mechanism is super-imposed on the already declining rate of net Delta(4)-steroid release by the ovary. 5. A relationship of these pathways to subcellular compartments of luteal cells is proposed.


Assessment of proximal tubular sodium reabsorption during water diuresis in patients with heart disease. In order to examine the relation between cardiac state and the capacity to excrete a water load, 10 normal subjects and 61 patients with heart disease were studied during water diuresis. Under these conditions, urine flow approximates to the rate of delivery of filtrate, and therefore of sodium, from the proximal tubule of the kidney to the loop of Henle, while free water clearance is a function of distal sodium reabsorption. In 12 patients with complete heart block, ventricular pacing was associated with increased urine flow and free water clearance. Oral propranolol in 3 normal subjects and in 9 patients with intact atrial septa caused a reduction, and oral practolol in 4 normal subjects and 8 patients caused no change. In 6 patients with atrial septal defect, propranolol was without effect. Maximum urine flow correlated with left ventricular end-diastolic pressure but not mean left atrial pressure in 16 patients with chronic rheumatic heart disease. In 7 patients with ischaemic heart disease, maximum urine flow was higher than in those with chronic rheumatic heart disease and similar increase in left ventricular end-diastolic pressure. These results reflect a close relation between proximal tubular sodium reabsorption and cardiac state, and suggest that inappropriate sodium reabsorption at this site may contribute to fluid retention in heart disease.


1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1: a potent beta-adrenoreceptor antagonist. 1. The beta-adrenoceptor blocking activity of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCl (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip.2. USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 mug/kg and higher. On the basis of comparative pA(2) values, USVC 6524 is approximately 10 times more potent as a beta-adrenoceptor antagonist than propranolol.3. Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong beta-adrenoceptor blockade.4. USVC 6524 also blocked beta-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.


Prejunctional actions of some beta-adrenoreceptor antagonists in the vas deferens preparation of the guinea-pig. 1. The beta-adrenoceptor antagonists propranolol, pronethalol, MJ 1999 and Ciba 39089-Ba reduced responses to field stimulation of the guinea-pig isolated vas deferens preparation without significantly affecting responses to exogenously added noradrenaline.2. This prejunctional blocking action of the drugs cannot be correlated with their action as beta-adrenoceptor antagonists or non-specific depressants.3. The blockade produced was more pronounced at low (5-20 Hz) than at high (50 Hz) frequencies of stimulation.4. The blockade was slow in onset, and once established was poorly reversed by washing the preparation over a period of 1 to 2 h.5. The blockade produced could be reversed by dexamphetamine and cocaine.6. These experiments suggest that the beta-adrenoceptor antagonists may have some actions which closely resemble those of the adrenergic neurone blocking agent guanethidine.


The effect of graded doses of practolol on the tachycardia induced by isoprenaline, Valsalva's manoeuvre and exercise.


Observations on the sub-division of beta-adrenoreceptors in the circulation of the dog.


Evidence for separate receptors for melanophore stimulating hormone and catecholamine regulation of cyclic AMP in the control of melanophore responses. 1. Skins of the lizard Anolis carolinensis darken in vitro in response to melanophore stimulating hormone (MSH), a peptide hormone, as well as to catecholamines. These hormones darken Anolis skins by dispersing the sub-cellular organelle, the melanosome, out into the dendritic processes of the dermal melanophores.2. Dibutyryl cyclic AMP and methylxanthines also darken skins. In addition, methylxanthines are synergistic with both catecholamines and MSH in causing skin darkening. These data suggest that the dispersion of melanosomes within melanophores in response to both MSH and catecholamines is mediated by cyclic AMP.3. alpha-Adrenoceptor blocking agents inhibit MSH-induced darkening but potentiate catecholamine-induced darkening. beta-Adrenoceptor blocking agents, in contrast, inhibit catecholamine-induced darkening but have no effect on MSH-induced darkening. This selective blockade of one receptor while the functional integrity of the other receptor is maintained suggests that MSH and catecholamines increase cyclic AMP levels through different receptors.4. Catecholamines exert their action through beta-adrenoceptors; MSH darkens skins through what appears to be a component of the alpha-adrenoceptor. beta-Adrenoceptor stimulation may stimulate adenyl cyclase to increase cyclic AMP levels whereas MSH may inhibit cyclic AMP phosphodiesterase thereby preventing cyclic AMP breakdown.


Apparent correlations between pA2 and pD2' values in a group of drugs with antihistaminic and anticholinergic properties.


Effects of bethanidine on response to ergotamine and noradrenaline.


Two simple, relatively inexpensive, devices to measure the locomotor activity of anaesthetized or unanesthetized animals.


Undescended testis.

Undescended testis.


Space craft.

Space craft.


Effect of a combination of two cariostatic agents in children: two-year clinical study of supervised brushing in children's homes.


The current status of topical fluorides in preventive dentistry. Council on Dental Therapeutics.


Chemical additives in rumen fermentations: in vitro effects of various drugs on rumen volatile fatty acids and protozoa.


Protection by catatoxic steroids against phenindione overdosage.


Specific gravity and osmolality of human parotid fluid.


The dentition of diabetics.

The dentition of diabetics.


Dental problems and dental care during moon flights.


For and against smallpox vaccination.

For and against smallpox vaccination.


Clinical evaluation of practolol, a new cardioselective beta-blocking agent in angina pectoris. In a controlled double-blind study practolol, a new cardioselective beta-blocking drug, was given to 15 patients with angina pectoris, and compared with propranolol 80 mg. q.d.s. The dose of practolol ranged from 200 to 600 mg.b.d. and was decided by initial open titration in individual patients. Though practolol did not influence the incidence of angina or glyceryl trinitrate consumption, it increased the duration of exercise possible in exercise tests and reduced the amount of ischaemic S-T depression in the radiocardiogram during exercise. Propranolol reduced the incidence of angina and, in the exercise tests, increased the amount and duration of exercise but did not affect the degree of S-T depression. Unlike propranolol, practolol did not produce any adverse effects on bronchial smooth muscle. Hence it is concluded that practolol is an effective drug in treating angina, and in the dosage used is of potential value in patients with asthmatic bronchitis and angina. It should, however, be used cautiously in anginal patients with heart failure.


Practolol in treatment of angina pectoris. A double-blind trial. Twenty-four patients with angina pectoris entered a double-blind trial of the cardioselective beta-adrenergic blocking agent practolol. Seventeen experienced less angina and consumed fewer glyceryl trinitrate tablets when on the active preparation. There was also a decrease in the mean number of attacks suffered by patients while on practolol and a reduction in the number of glyceryl trinitrate tablets taken. These results are of statistical significance at, at least, the 5% level.


Fluorescence studies of NAD(P)H binding in intact cells.


Interaction of gluconeogenesis and mixed function oxidation.


Effects of quinolinic acid on the free and total nicotinamide-adenine dinucleotides of rat liver.


Infrared identification of some hallucinogenic derivatives of tryptamine and amphetamine.


Effects of pharmacological inhibition of histamine synthesis upon immunological reactions in guinea-pigs.


Inhibition of enzymes by alkylsalicylic acids.


Some observations on the use of fatty alcohols and fatty acids to increase the consistency of oil-in-water emulsions.


A comparison of the effects of 6-hydroxydopamine immunosympathectomy and reserpine on the cardiovascular reactivity in the rat.


Potentiation of oxotremorine lethality by antihistamines.


Action of rare earth metal complexes on neurogenic as well as on bradykinin-induced inflammation.


The effect of isoniazid and some anticonvulsant drugs on the gamma-aminobutyric acid content of mouse brain in insulin hypoglycaemia.


The metabolism of butylated hydroxytoluene, (3,5-di-t-butyl-4-hydroxytoluene) in man.


On the dopaminergic nature of the gnawing compulsion induced by apomorphine in mice.


Pharmacological actions of pralidoxime in relation to therapeutic doses.


Cardiac effects of strychnine and their mechanism.


The action of desipramine on noradrenaline depletion by reserpine in the vas deferens of the rat in vivo.


The effect of histamine releasers on the output of prostaglandins from rat diaphragms.


Oxotremorine: acute tolerence to it and its central "cholinolytic" effect in mice.


Blockade of noradrenaline uptake and inhibition of gastric acid secretion by 2-[p-chlorophenyl-2-(pyridyl)hydroxymethyl] imidazoline maleate (Sch-12650).


Potentiation of the central actions of 5-hydroxytryptophan in rabbits by DL-alpha-hydrazino-alpha-methyldopa.


Identification of cannabis.

Identification of cannabis.


Nerve biopsy. Choice of nerve, method, symptoms, and usefulness.


Studies on the combined use of beta-adrenergic blockade and antiarrhythmic drugs.


Mechanisms of change in thoracic duct lymph flow during hypotensive states.


Light-scattering studies on rabbit brain microsomes. 3. Coupling of cytochrome b5 and related oxidative activities with microsomal contraction.


Possible regulatory function of a mitochondrial ATPase inhibitor in respiratory chain-linked energy transfer.


Biosynthesis of D-apiose. V. NAD+-dependent biosynthesis of UDP-apiose and UDP-xylose from UDP-D-glucuronic acid with an enzyme preparation from Lemna minor L.


Histochemical demonstration of certain testicular enzymes of the Indian desert gerbil Meriones hurrianae Jerdon and their response to unilateral cryptorchidism.


Human gonadotrophins: a review of recent developments.


Fractionation of immunocompetent spleen cells by albumin density gradient centrifugation.


The role of bacterial antagonism in pneumococcal colonization of the human pharynx.


Septic survival of rabbits induced by in vivo phytohemagglutinin.


Doxapram (Dopram)--an analeptic.

Doxapram (Dopram)--an analeptic.


Bone marrow transplantation: correction of immune deficit in lymphopenic immunologic deficiency and correction of an immunologically induced pancytopenia.


Some hints to avoid pitfalls in quantitative determination of glutathione peroxidase (EC 1.11.1.9).


The role of the spleen in protozoal infections with special reference to splenectomy.


The piercing mechanism of the fruit-piercing moth calpe [calyptra] thalictri bkh. (noctuidae) with reference to the skin-piercing blood-sucking moth c. eustrigata hmps.


The stimulation of emergence from glossina pupae with gamma rays.


Effects of 2-deoxy-D-glucose on insulin-secretory responses to intravenous glucose, glucagon, tolbutamide and arginine in man.


Antimicrobial activity of local anesthetics: lidocaine and procaine.


Resuscitation of the newborn.

Resuscitation of the newborn.


Fine structure of regenerating endothelium and Descemet's membrane in normal and rejecting corneal grafts.


Exchange autografts of skin in lupus erythematosus.


Radioactive xenon tissue clearance: standardization for measurement of peripheral blood flow.


Stool porphyrins in acute intermittent and hereditary coproporphyria. Adverse effect of tranquilizers.


Ethanol oxidation by liver microsomes: evidence against a separate and distinct enzyme system.


A new reaction of glutamate dehydrogenase: the enzyme-catalyzed formation of trinitrobenzene from TNBS in the presence of reduced coenzyme.


Time-dependent increase in rat mammary uridine diphosphate glucose 4-epimerase activity in vitro.


Saccharopine cleavage by a dehydrogenase of human liver.


Pharmacology of the cerebral circulation.


Alteration of enzyme activity in rat liver following the acute and chronic administration of nicotine.


Effects of chronic nicotine, acute hypoxia, and their interactions on myocardial enzymes.


Effects of prototype space diet on the bacterial fecal flora of humans.


Cycle to somewhere. One conferee's reaction to the 1969 White House Conference on Food, Nutrition, and Health.


Effect of beta-receptor blocking drugs on the heart rate during submaximal exercise.


A time-sharing instrument for direct readout of oxidation-reduction states in intracellular compartments of cardiac tissue.


Introduction to the Symposium on Immunity to Selected Canine Infectious Diseases.


Pharmacologic properties and mechanism of action of amfonelic acid.


The fine structure of the spermatozoon of Pennaria tiarella (coelenterata).


Studies on damage to the liver by alcohol.


Memory and disorders.

Memory and disorders.


Advantages of an antagonist.

Advantages of an antagonist.


Three phases of chloroplast research.

Three phases of chloroplast research.


Great Barrier Reef: crown-of-thorns not so fatal.


Synergism between thymocytes and bone marrow cells in a graft versus host reaction.


GABA, bicuculline and central inhibition.


Pathological consequences of artificial cold acclimatization.


Autonomic innervation, sex steroids and uterine contractility.


The relationship between dental conditions and the trace element molybdenum.


Mouth rinses with potassium fluoride solutions containing manganese.


A novel alcohol dehydrogenase present in Rhodomicrobium vannielii.


Tamworth dental survey results 1963, 1969.


Caries reduction in a single annual topical application of acidulated phosphate fluoride.


Women's prisons--available populations for dental research. II. The oral findings of female inmates.


Dental needs and prevalence of dental caries in Wayne County grade school children.


Hazard to teeth of young children.

Hazard to teeth of young children.


Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue.


Estimation of immunological competence of lymphocytes from rat blood by graft versus host reaction.


Acceleration of ventricular pacemakers by transient increases in heart rate in dogs during ouabain administration.


Blood flow, oxygen consumption, and free fatty acid release in subcutaneous adipose tissue during hemorrhagic shock in control and phenoxybenzamine-treated dogs.


Effects of intra-aortic balloon counterpulsation on cardiac performance, oxygen consumption, and coronary blood flow in dogs.


Intermittent jaundice: the result of a prolapsed gastric tumor occluding the common bile duct.


Histochemical demonstration of oxidoreductase activity in the canine ovary.


Therapy for AHF and PTC hemophilia. II.

Therapy for AHF and PTC hemophilia. II.


Retroperitoneal mass.

Retroperitoneal mass.


Adaptation of cardiac catheterization techniques for insertion of intravascular cardiac pacemakers.


Reading and learning problems. Ophthalmological management.


Sustaining the mood to diet. The clinician's role.


Health care in the 70's.

Health care in the 70's.


Illicit LSD users: their personality characteristics and psychopathology.


Malate dehydrogenases and glutamate dehydrogenase in chick liver and heart during embryonic development.


What is asthma?

What is asthma?


The effect of tritoqualine on anaphylactic and anaphylactoid shock in rats, evaluated by renal enzyme excretion studies.


Role of hydrophobic interactions in enzyme inhibition by drugs.


Catalytic properties of the lactate dehydrogenase isozyme "X" from mouse testis.


A comparison of the range of attraction of animal baits and of carbon dioxide for some West African mosquitoes.


Effect of dexamethasone on pituitary-adrenal activation following intrahypothalamic implantation of "neurotransmitters".


Effect of x-irradiation on hydra in the presence of arginine and citruline and study of the radiolytic products.


Effects of irradiation on sub-cellular components. I. Lipid peroxide formation in the endoplasmic reticulum.


Purification and properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa.


Studies on the mechanism of chloramphenicol impairment of human leukocyte function.


Photochemical activities of spinach chloroplast particles fractionated after French press treatment.


The effect of flurothyl and electroshock on pulmonary diffusion.


Coagulation changes in hyperacute rejection of renal xenografts.


The effect of psychostimulants on psychometric test performance with special reference to conflict avoidance behavior.


Proceedings of the 4th annual conference on atmospheric contamination in confined spaces. 10-12 September 1968. AMRL-TR-68-175.


Review of tentative abort, alert, 100 and 1000-day limits for space cabin contaminants. AMRL-TR-68-175.


Contaminant trapping and effect of surface adsorption on atmospheric concentration of contaminants. AMRL-TR-68-175.


An improved contaminant sensing technique for laboratory and spacecraft application. AMRL-TR-68-175.


Humoral antibodies and coagulation mechanisms in the accelerated or hyperacute rejection of renal homografts in sensitized canine recipients.


General instrumental approaches to trace chemical analysis in closed ecological systems. AMRL-TR-68-175.


The determination of chlorinated hydrocarbons at low concentrations in closed atmospheres. AMRL-TR-68-175.


Design of a closed recirculating system for testing specific cabin materials in a 5 PSIA mixed-gas atmosphere. AMRL-TR-68-175.


Fire extinguishing systems for space cabin simulators. AMRL-TR-68-175.


A comparison of experimental control animals housed in altitude chambers and animal rooms. AMRL-TR-68-175.


Philosophy of 100-day and 1000-day limits for space cabin atmospheres. AMRL-TR-68-175.


Relationship of results of long-term toxicity studies to those of shorter duration. AMRL-TR-68-175.


Interactions between some psychodrugs and flavins.


Light amplified inhibition of oxidative phosphorylation by chlorophyllins in rat liver mitochondria.


Biochemical effects in the rabbit of repeated administration of a mixture of DDT, carbaryl, and parathion.


On the structure and synaptic organization of the first optic ganglion in the fly.


Folate deficient mutants of Saccharomyces cerevisiae.


IgG and IgA antipneumococcal antibodies in human serum, colostrum and saliva.


Some observations on true latency and long-term relapses in P. vivax malaria.


The pentose phosphate pathway in cystic fibrosis erythrocytes.


Psychiatric disorders after surgery for duodenal ulcer. A prospective trial was conducted to determine the relationship between personality type and the results of surgery for peptic ulcer. Previous investigations had suggested that patients with an obsessional personality fared less well than those who were not obsessional. However, although there was a high incidence of psychiatric disorders in these surgical patients no significant difference was found between the two groups. It was concluded that classifying patients as obsessional and non-obsessional did not have any bearing on the outcome of operation.


Ineffectiveness of isoxsuprine on intermittent claudication.


Continuing education of the rheumatologist and the nonspecialized practitioner.


Antagonism of D-amphetamine by alpha-methyl-L-tyrosine: behavioral evidence for the participation of catecholamine stores and synthesis in the amphetamine stimulant response.


Mass self-administered stannous fluoride prophylactic paste.


Identification of 7 alpha-hydroxylated androgens as the metabolites of androstenedione by testicular microsomal fraction of rats.


On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase.


Pyridine nucleotide oxidized to reduced ratio as a regulator of muscular performance.


Protection tests on bronchial allergen challenge with disodium cromoglycate and thiazinamium.


Ultrastructural localisation of NADH- and NADPH-dehydrogenases in the erythrocytic stages of the rodent malaria parasite, Plasmodium berghei.


Management of a case of triad syndrome: combined urological and plastic approach.


Blood fibrinolytic activity in skin diseases.


Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog.


Effect of ganglion-blocking agents on renin release in hypertensive patients.


"Testicular feminization" in the rat: Morphology of the testis.


Effects of the amnesic agent flurothyl on EEG and multiple-unit activity in the chick.


Sleep duration and feeling state.

Sleep duration and feeling state.


Beta adrenergic blocking properties of D and DL propränolol in man.


A central effect of angiotensin: release of pituitary pressor material.


Mesenteric vasoactivity associated with eating and digestion in the conscious dog.


Chronic granulomatous disease in females.


Coronary hemodynamic effects of ethyl alcohol in the conscious dog.


Influence of ganglionic blockade on catecholamine and metabolite excretion.


Adrenergic receptors and ggeographic variation in Rana pipiens chromatophore responses.


Levels of pyridine nucleotide coenzymes during parathyroid hormone-induced inhibition of citrate-decarboxylation in calvaria in tissue culture.


Automated personality assessment in medical practice.


The effect of "selective" beta-adrenoceptor blocking drugs on the myocardial circulation. 1. A comparison has been made of the effects of a relatively specific beta(1)-adrenoceptor blocking drug (practolol) and a relatively specific beta(2)-adrenoceptor blocking drug (butoxamine) on myocardial and general haemodynamics in anaesthetized cats.2. Practolol, in a dose (10 mg/kg, intravenously) which had little effect on arterial pressure, heart rate, myocardial blood flow or myocardial vascular resistance, markedly reduced the effects of isoprenaline infusions on heart rate, aortic dp/dt, myocardial blood flow, vascular resistance and metabolic heat production, and the cardiac effort index. Isoprenaline induced vasodepression was unaffected.3. Butoxamine (5 mg/kg, intravenously) decreased heart rate, aortic dp/dt, the cardiac effort index and myocardial blood flow and increased myocardial vascular resistance. This is taken as further evidence for the existence of beta(2)-adrenoceptors in the myocardial microcirculation.4. After butoxamine, the effects of isoprenaline on myocardial blood flow, myocardial vascular resistance and heart rate were unaffected but the peripheral vasodilator effect was abolished. The effects on aortic dp/dt and the cardiac effort index were potentiated.5. It is concluded that the effect of isoprenaline in increasing myocardial blood flow is due predominantly to increased cardiac work and oxygen consumption and that practolol, since it has little direct effect on myocardial blood flow yet abolishes the cardiac stimulant and oxygen wasting effects of released catecholamines, has properties which indicate that it should be an effective and safe anti-anginal drug.


Interactions of inhibitors of noradrenaline uptake and angiotensin on the sympathetic nerves of the isolated rabbit heart. 1. The interaction of angiotensin and several inhibitors of the uptake of noradrenaline across the neuronal membrane (cocaine, desipramine, protriptyline. and pronethalol) on the output of noradrenaline produced by sympathetic nerve stimulation has been studied in the isolated perfused rabbit heart.2. Most of these drugs increased noradrenaline outflow-angiotensin, for example, by 175%. Cocaine (10(-4)M) did not change the amine overflow, probably because this very high concentration inhibited not only the re-uptake but also the liberation of noradrenaline.3. Desipramine, protriptyline, and pronethalol, although infused in concentrations which enhanced the noradrenaline output, were not able to impair the angiotensin-induced increase of transmitter overflow. In the presence of cocaine (10(-4)M) the increase elicited by angiotensin was slightly reduced, though lower concentrations of cocaine, as previously described, do not interfere with the effect of angiotensin.4. In contrast to the interaction between uptake inhibitors and angiotensin, the augmented output of noradrenaline caused by an uptake inhibitor could not be increased further by infusion of a second uptake inhibitor.5. It is concluded that the increase of the outflow of noradrenaline during sympathetic nerve stimulation by small doses of angiotensin is not caused by an inhibition of re-uptake. On the contrary, the transmitter liberation seems to be facilitated. This is a novel principle of drug action on the sympathetic nerve terminals.


The effect of reserpine on the pressor responses to angiotensin in the conscious cat. 1. Blood pressure recordings have been made in conscious cats in an attempt to reveal a possible indirect component to the angiotensin pressor response.2. Reserpine (50 to 250 mug/kg per day) caused a maximal reduction of about 50% in the pressor response to angiotensin whilst virtually abolishing the responses to tyramine and McN-A-343. Responses to noradrenaline were only slightly and transiently reduced.3. Syrosingopine (0.5 mg/kg) and reserpine (250 mug/kg) reduced the responses to angiotensin, McN-A-343 and tyramine to much the same extent, but tetrabenazine only reduced the responses to all these agents in a dose (25 mg/kg) which probably had effects on the catecholamine stores of smooth muscle.4. The reduction in the responses to angiotensin, tyramine and McN-A-343 by reserpine was partly reversed by tranylcypromine. Noradrenaline and (+/-)-dopa infusions were ineffective by themselves, but increased the effects of tranylcypromine in restoring the responses to angiotensin, tyramine and McN-A-343 after reserpine.5. Infusion of alpha-methyldopa markedly increased the responses to angiotensin, tyramine and McN-A-343 after these had been reduced by reserpine.6. The results suggest that the pressor response to angiotensin in the conscious cat is partly mediated by release of noradrenaline from peripheral neuronal stores.


The release of acetylcholine by acetylcholine in the cat's superior cervical ganglion. 1. The experiments described in this paper tested the effect of acetylcholine (ACh), carbachol or preganglionic nerve stimulation on the release of ACh from the cat's perfused superior cervical ganglion; radioactive tracer methods were used.2. When the ganglion's transmitter store of ACh had been labelled, radioactive ACh was released by nerve stimulation (5 Hz for 2 min), but there was no release by ACh (0.15-15 mug) or by carbachol (1-10 mug) when these drugs were injected close to the ganglion. Perfusion with low or moderate concentrations of ACh (0.15-5 mug/ml) also failed to release ACh, but high concentrations (15-50 mug/ml) released a small amount of labelled material. There was no correlation between ganglion stimulation by ACh and release of radioactivity.3. Ganglion-blocking concentrations of ACh did not reduce the release of ACh during continuous nerve stimulation.4. When resting (unstimulated) ganglia were perfused with (3)H-choline and eserine, the extra ACh synthesized and stored by such ganglia (surplus ACh) was labelled. Preganglionic nerve stimulation (5 Hz for 2 min) did not release surplus ACh, but perfusion with ACh (0.5-15 mug/ml), or injection of carbachol (0.5-2.5 mug) did.5. Surplus ACh released by ACh or by carbachol did not contribute to the ganglion stimulating effect of either drug.6. It is concluded that the presynaptic effects of ACh are not of physiological importance.


Beta-adrenoceptor stimulating properties of para-dimethylaminobenzaldehyde. 1. Studies on the various isolated tissues indicate that para-dimethylaminobenzaldehyde (DMAB) is a beta-adrenoceptor stimulant. DMAB is antagonized by the beta-adrenoceptor blocking agent, MJ 1999, but not by the alpha-adrenoceptor blocking agent, phentolamine.2. A study of dose-response relationships suggests a competitive interaction between MJ 1999 and DMAB.3. DMAB was about 122 times less potent than isoprenaline on the isolated guinea-pig tracheal preparation. The effects of DMAB on isolated rabbit atria were not only very weak, but were also very brief. On this tissue, DMAB was respectively 72,000 and 55,400 times less active than isoprenaline in producing positive chronotropic and inotropic effects. DMAB caused the relaxation of the guinea-pig taenia coli and the rabbit ileum. These actions were very weak in comparison with those of isoprenaline.4. These results suggest that a compound (DMAB) structurally different from isoprenaline may mimic isoprenaline responses by stimulating beta-adrenoceptors through different mechanisms.


The case against the use of respiratory stimulants.


The use of "respiratory stimulant" drugs.


Discovery and geographic distribution of Venezuelan encephalitis virus in Guatemala, Honduras, and British Honduras during 1965-68, and its possible movement to Central America and México.


Combined effect of trace elements and fluorine on caries.


Relationship of concentrations of eleven elements in public water supplies to caries prevalence in American schoolchildren.


Sotalol-induced beta blockade in cardiac patients.


Personality factors in college drug users.


Some social factors in college drug usage.


A comparative study of growth and development in Florida mosquitoes. I. Effects of environmental factors on ontogenetic timings, endogenous diurnal rhythm and synchrony of pupation and emergence.


Feeding habits of five species of Deinocerites mosquitoes collected in Panama.


A comparative study of growth and development in Florida mosquitoes. 2. Effects of larval nurture on adult characteristics at emergence.


A betalight trap for mosquito larvae.

A betalight trap for mosquito larvae.


Proceedings of the First International Workshop on Tissue Valves October 4-5, 1969.


The bronchoconstrictor action of capsaicin in the guinea pig.


Immunologic effects of heterologous antilymphocytic sera.


Ultrastructural investigations on the inflammatory response in skin allografts.


The effect of depth of anesthesia on the neuromuscular refractory period of anesthetized man.


Anesthetic effects on baroreceptor reflexes.


A note on the biotransformation of fluroxene in two volunteers.


Stimulatory effect of exogenous catecholamines on plasma HGH concentrations in presence of beta adrenergic blockade.


In vitro assembly of Neurospora assimilatory nitrate reductase from protein subunits of a Neurospora mutant and the xanthine oxidizing or aldehyde oxidase systems of higher animals. In vitro assembly or complementation of a hybrid assimilatory nitrate reductase was attained by mixing a preparation of nitrate-induced N. crassa mutant nit-1 specifically with acid-treated (pH 2.5) bovine milk or intestinal xanthine oxidase, rabbit liver aldehyde oxidase, or chicken liver xanthine dehydrogenase. The complementation reaction specifically required induced nit-1, the only nitrate reductase mutant of Neurospora that lacked xanthine dehydrogenase and was unable to use hypoxathine or nitrate as a sole nitrogen source. The complementing activities of the above acid-treated enzymes correspond to their xanthine or aldehyde oxidizing activity profiles on sucrose density gradients. The resulting soluble, reduced nicotinamide adenine dinucleotide phosphate (NADPH)-nitrate reductases are the same as the Neurospora wild type enzyme in sucrose density gradient profile, molecular weight, substrate affinities, and sensitivity to inhibitors and temperature. By analogy to a similar in vitro complementation of nitrate reductase in mixtures of induced nit-1 and individual nonalleic Neurospora mutants, or uninduced wild type, the complemented nitrate apparently consists of an inducible protein subunit (possessing inducible NADPH-cytochrome c reductase) furnished by nit-1 and a subunit from the acid-treated xanthine or aldehyde oxidizing system which can substitute for the constitutive component furnished by the other mutants or uninduced wild type. The data suggest that Neurospora nitrate reductase and the xanthine oxidizing system and aldehyde oxidase of animals, all of which are molybdenum-containing enzymes catalyzing the reduction of nitrate to nitrite, share a highly similar protein subunit.


Isozyme patterns and sexual morphogenesis in Schizophyllum. Isozymes of several different classes of enzymes in partially purified protein extracts of five strains of Schizophyllum commune, isogenic except for genes controlling sexual morphogenesis, were separated on polyacrylamide gel by disc electrophoresis. After staining, isozyme patterns were compared on the bases of the presence or absence, electrophoretic mobility (R(f) values), and relative activities of specific isozymes. Differences in isozyme patterns in 14 enzymes, i.e., NADH-dehydrogenase, NADPH-dehydrogenase, a number of NAD and NADP-dependent dehydrogenases, acid phosphatases, leucine aminopeptidase, and esterases, were correlated with the operation or inactivity of the A-and B-sequences of sexual morphogenesis. In only a single instance, i.e., phenolases, no marked differences could be correlated with sexual morphogenesis.


Isolation and characterization of structurally homogeneous antibodies from antipneumococcal sera. Antibodies of sufficient homogeneity for sequence studies were readily obtained in high concentrations from rabbits immunized with pneumococcal vaccines. By taking advantage of slightly differing immunologic specificity for Type III and Type VIII capsular polysaccharides, an antibody with unique electrophoretic mobility could be isolated from serum containing several distinct antibody components by using appropriate cross-reacting immunoadsorbents. A unique sequence for the N-terminal 11 amino acid residues of the light chain of the antibody was found, in contrast to several sequences in the antibody mixture from which this component was isolated. The sequence of a nonimmune light chain pool demonstrates even greater heterogeneity. Chymotryptic peptide maps of the antibody light chain show two unique cysteine-containing variable region peptides not seen in maps of nonimmune light chain pool of the same allotypic specificity as that of the antibody light chain. The experimental approach described here may provide further insight into the structure-function relationship of several homogeneous antibodies of closely related specificity for the same polysaccharide antigen.


Caries experience during a decade.

Caries experience during a decade.


Glycolipids of marine invertebrates.

Glycolipids of marine invertebrates.


A survey of the oral health of a group of orthopedically handicapped children.


Oral contraceptives: depression and frigidity.


Subcellular distribution of aromatic amino acid transaminases in rat brain.


Localization of tyrosine aminotransferase in brain.


Effect of pronethalol on left ventricular volumes of dogs during hemorrhagic shock.


Enzymes of carbohydrate metabolism in the rat cerebellum developing in situ and in vitro.


Ascaridia galli: lactic acid production, glycogen content, glycolytic enzymes and properties of purified aldolase, enolase and glucose-6-phosphate dehydrogenase.


Morphological study of organs, blood cells and bone marrow of white rats and mice with "vaccinial disease".


Tolerance of rhesus monkeys to graded increase in environmental CO2: Serial changes in heart rate and cardiac rhythm.


Reflections on beta-adrenergic blockade in anaesthetics.


Antiasthmatic action of sympathomimetics: a review of the literature on their bronchopulmonary effects.


The amino acid content of sea nettle (Chrysaora quinquecirrha) nematocysts.


Steroid induction of phenylethanolamine-N-methyl transferase in adrenomedullary explants: independence of adrenal innervation.


A comparative study of the effects of methaqualone and glutethimide on sleep in male chronic insomniacs.


The effect of alpha-ketoglutarate and other alpha-keto acids on the recovery of tyrosine aminotransferase activity from chick embryo liver.


Study of differences in the occurrence of dental caries in Caucasian and Negro children.


Biological phosphonates: determination by phosphorus-31 nuclear magnetic resonance. Advanced methods of phosphorus-31 nuclear magnetic resonance spectroscopy provided a method whereby biological phosphonates and phosphates can be determined on simple lipid fractions of biological origin. The spectra consist of two easily distinguished resonance bands; one corresponds to families of phosphonates, and the other corresponds to families of orthophosphates.


Arthralgia.

Arthralgia.


Studies of adjuvant-induced arthritis in the albino rat (CFN strain).


Significance of antinuclear factor in the connective tissue diseases.


Mechanism of epinephrine and serotonin inhibition of insulin release in the golden hamster in vitro.


Ipecac-induced emesis for acute poison ingestion.


Editorial. Annual general meeting of the Irish Guild of Catholic Nurses.


Effects of a space-cabin atmosphere on the immune response. II. Histochemical and biochemical alterations in oxidative enzyme activity.


Effects of a space-cabin atmosphere on the immune response. I. Depression in spleen weights and antibody titers.


Treatment of the poisoned child.

Treatment of the poisoned child.


Effects of postulated neurohumoral transmitters on the isolated radula protractor of Busycon canaliculatum.


New compounds: some potential chemotherapeutic agents derived  from aralkyl ketones.


Pharmacological evaluation of seizures induced by electrical stimulation of the hippocampus.


Immunological evidence for the presence of latent Ca2 dependent ATPase and carboxydismutase on the thylakoid surface.


Preliminary report on the protection from Ehrlich ascites tumor with tumor cells photoinactivated in the presence of psoralen or 8-methyl-psoralen.


Patient sex differences and MMPI changes--1958 to 1969.


The structure of Leuconostoc mesenteroides Strain C dextran. I. Methylation analysis.


Multiple antibiotic resistance in a bacterium with suppressed autolytic system.


Transmitter release by presynaptic impulses in the squid stellate ganglion.


Incomplete dosage compensation for glucose-6-phosphate dehydrogenase in human embryos and newborns.


Quantitative determination of emetine and cephaëline in ipecacuanha root and its preparations.


Pharmacological investigations of the essential oil of Colubrina asiatica.


Caries prevalence in a Finnish rural population.


Student dental health program of the University of Alabama in Birmingham. 3. The influence of third molars on DMF counts.


Weight loss and psychological observations of gynecological patients. II.


Final report on the efficacy of a stannous fluoride-calcium pyrophosphate dentifrice.


Specificity of certain biochemical derangements in hepatocarcinogenesis. Earlier work on acid-soluble nucleotides and other liver constituents as affected by azo-dye carcinogenesis has now been extended, with trial of ethionine (weakly carcinogenic) and of α-naphthylisothiocyanate (noncarcinogenic). The effects of ethionine feeding on whole-tissue nucleotide levels were not dramatic, and were generally dissimilar to those produced by azo-dye feeding. However a fall in some or all of the purine nucleotides can still be regarded as a feature of hepatocarcinogenesis.A fall in mitochondrial nucleotides, as previously found in azo-dye experiments, likewise occurs with ethionine feeding, but also with α-naphthylisothiocyanate. It is suggested that the latter warrants testing as a co-carcinogen. Unlike azo-dyes, ethionine is without adverse effect on the yield of protein in cytoplasmic particles and (in common with α-naphthylisothiocyanate) it raises the yield of RNA in the supernatant fraction.In liver from ethionine-fed rats and in ethionine-induced hepatomas, the activity of enzymes concerned in UMP synthesis showed a rise more striking than that found with azo-dyes.


Comparison of the effect of alprenolol and propranolol on specific airway conductance in asthmatic subjects. Alprenolol did not cause a significant fall in the mean of the specific airway conductance in nine asthmatic subjects who did show a significant fall with propranolol. Thus alprenolol is not contraindicated in asthmatic subjects, though it should be used with caution intravenously, as one subject showed a substantial fall in airway conductance at three minutes which recovered within 30 minutes. Until further studies are completed these results should not be applied to bronchitics with increased airway resistance.


Diquat cataract: formation of the free radical and its reaction with constituents of the eye.


Cord paralysis following injection into traumatic cervical meningocele. Complication of stellate ganglion block.


Multiple forms of aspartate oxoglutarate transaminase and malate dehydrogenase in resting cottonseeds.


Glutamate dehydrogenase in Azotobacter chroococcum.


Dehydrogenation of glucose and xylose catalyzed by rat and sheep liver microsomal and soluble fractions.


Comparative beta-blocking activities and effects on sodium excretion of sotalol and propranolol.


Coexistent hyperthyroidism and hyperparathyroidism.


Folate reductase of the amethopterin-resistant Streptococcus faecium var. durans-Ak. I. Inhibition by amethopterin and methasquin, a new quinazoline antifolate.


The stimulation of adenyl cyclase of rat erythrocyte ghosts.


Kinetics of induction of rat liver enzymes by glucocorticoids.


Cell division during regeneration in Hydra.


Steroid dehydrations in porcine subcellular fractions.


Fluorides and dental health.

Fluorides and dental health.


Polyarteritis nodosa of the gallbladder and bile ducts.


Adrenergic mechanisms in the systemic plasminogen active response to adrenaline in man.


Comparative trial of serotonin antagonists in the management of migraine. The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with BC105 were significantly better than those with placebo (P<0.02). The total improvement rates with methdilazine (45%) and cyproheptadine (43%) were better than those with placebo (32%) but did not achieve statistical significance. A new preparation, methylergol carbamide maleate, which is chemically related to methysergide, did not give better results than placebo.


A role of inductive factors in interstitial cell differentiation in Hydra.


Rhinocytology and its diagnostic possibilities in allergy.


The effect of granule properties on the pore structure of tablets of sucrose and lactose.


Vascular smooth muscle. II. Pharmacology of normal and hypotensive vessels.


Glucocorticoids in the connective tissue diseases.


Increment of dental caries over two years of fluoridation of domestic salt. A preliminary report.


Tissue damage in disseminated intravascular coagulation--mechanisms of localization of thrombi in the microcirculation.


Glucocorticoids in allergic diseases.

Glucocorticoids in allergic diseases.


Some properties of urea dehydrogenase in tissues of higher plants.


Nature of the inactivation of the isocitrate dehydrogenase from an obligate halophile. The nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenase (ICDH) of Halobacterium cutirubrum is rapidly inactivated at low NaCl levels. From sucrose gradient analysis, it was estimated that the active ICDH has an S(20,w) of 5.3 and a molecular weight of 75,000. The inactivation by removal of NaCl causes an unfolding of the protein yielding a less-compact conformer with an S(20,w) of 2.0. This inactivation apparently causes internal sulfhydryl groups to be exposed. Over 90% of the initial activity can be restored by dialyzing the inactivated ICDH against 4 m NaCl, provided that the exposed sulfhydryl groups are protected with dithiothreitol. The ICDH is permanently inactivated when the sulfhydryl groups are oxidized or alkylated. The alkylation of the inactive ICDH was demonstrated by treatment with (14)C-N-ethyl maleimide. Sucrose gradient analysis showed that (14)C was bound to a protein with sedimentation properties identical to that of reversibly inactivated ICDH, i.e., an S(20,w) of 2.0. Much less (14)C was bound when active ICDH was treated with (14)C-N-ethyl maleimide. The H. cutirubrum ICDH resembles other bacterial isocitrate dehydrogenases in being susceptible to concerted feedback inhibition by oxalacetate and glyoxalate.


Skin lesions as a diagnostic aid in barbiturate poisoning.


Bacteriophage tail components. II. Dihydrofolate reductase in T4D bacteriophage. The protein component of the T-even bacteriophage coat which binds the phage-specific dihydropteroyl polyglutamate has been identified as the phage-induced dihydrofolate reductase. Dihydrofolate reductase activity has been found in highly purified preparations of T-even phage ghosts and phage substructures after partial denaturation. The highest specific enzymatic activity was found in purified tail plate preparations, and it was concluded that this enzyme was a structural component of the phage tail plate. Phage viability was directly correlated with the enzymological properties of the phage tail plate dihydrofolate reductase. All reactions catalyzed by this enzyme which changed the oxidation state of the phage dihydrofolate also inactivated the phage. Properties of two T4D dihydrofolate reductase-negative mutants, wh1 and wh11, have been examined. Various lines of evidence support the view that the product of the wh locus of the phage genome is normally incorporated into the phage tail structure. The effects of various dihydrofolate reductase inhibitors on phage assembly in in vitro complementation experiments with various extracts of conditional lethal T4D mutants have been examined. These inhibitors were found to specifically block complementation when added to extracts which did not contain preformed tail plates. If tail plates were present, inhibitors such as aminopterin, did not affect further phage assembly. This specific inhibition of tail plate formation in vitro confirms the analytical and genetic evidence that this phage-induced "early" enzyme is a component of the phage coat.


Motor disturbance induced by tremorine and oxotremorine.


The effect of restraint and some ulcerogenic agents on the sulphation and turnover rates of gastrointestinal polysaccharides.


Airplane cockpit noise levels and pilot hearing sensitivity.


The tektite-I dive. Mycological aspects.


The endocrine pancreas in erythroblastosis fetalis.


Evidence for a temperature and ionic control of growth in Hydra viridis.


Trichloroethylene in combination with CNS drugs. Effects on visual-motor tests.


Homotransplant of the small intestine and the graft-versus-host reaction.


Morphology and histochemistry of the corneal epithelium of mammals.


Effects of anesthesia in therapeutic abortion.


Ventricular fibrillation and catecholamine responses during profound hypothermia in dogs.


The use and misuse of pressor agents.

The use and misuse of pressor agents.


Minimum alveolar concentrations in man on awakening from methoxyflurane, halothane, ether and fluroxene anesthesia: MAC awake.


Control of dental caries by the school dental service. The application of preventive treatment and incremental care.


Obtaining 16PF scores from the MMPI, and MMPI scores from the 16PF.


Ultrastructural studies on the life cycle of a short-lived metazoan, Campanularia flexuosa. II. Structure of the old adult.


The beta-adrenergic blockade hypothesis of asthma.


Summary of medical experience in the Apollo 7 through 11 manned spaceflights.


Disposition of newly synthesized amines in cell bodies and terminals of central catechol aminergic neurons. I. Effect of amphetamine and thiorproperazine on the metabolism of CA in the caudate nucleus, the substantia nigra and the ventromedial nucleus of the hypothalamus.


The clinical evaluation of a patient-administered SnF2-ZrSiO4 prophylactic paste in children. I. Results after one year in the Virgin Islands.


Critical review of contemporary cellulartherapy (celltherapy).


Elective surgery in hypertensive patients--preoperative considerations.


Contingency transfer system.

Contingency transfer system.


Osteoporosis: the state of the art. A symposium report.


Recent improvement in hypoxia warning systems.


Kinetic changes in microsomal drug metabolism with age and diphenylhydantoin treatment.


Toxicity of acids and bases after intraperitoneal injection.


The actions of selective beta-receptor antagonists on the guinea pig trachea.


Developments in the carotenoid field.

Developments in the carotenoid field.


Human skin-surface lipid fatty acids--mosquito repellents.


Strain differences in the lethal faster exerted by submandibular glands transplanted from male mice.


Stimulation of alpha- and beta-receptors in the isolated rat jejunum.


Comparison of beta-adrenergic blocking activity of DCI, H56-28, ICI50172, LB46, methoxamine, MJ1999 and propranolol in the blood perfused canine papillary muscle preparation.


Acrocephalosyndactyly type 3: Chotzen's syndrome.


The effects of excessive fluoride intake.


Dental caries and periodontal disease in girls of different ethnic groups. A comparison in a London secondary school.


Characterization of cell lines derived from Culiseta inornata and Aedes vexans mosquitoes.


Special application of fluorescence histochemistry: studies on eight monoamine oxidase inhibitors in brain neurons.


The effects of imidazole on adrenal metabolism in vitro.


Determination of brompheniramine in blood and urine by gas-liquid chromatography.


Morphological effects of intrauterine contraceptive devices.


Report of accidental poisoning death from fluid extract of Ipecac.


Report of fatality: spider bite (Loxosceles).


Prolapsus uteri with pelvic kidney.

Prolapsus uteri with pelvic kidney.


Epiphrenic diverticulum of the esophagus.


Gastric obstruction from gastrostomy tube.


Fractures of the hand.

Fractures of the hand.


The MMPI K+ profile: a reexamination.

The MMPI K+ profile: a reexamination.


Distinction between "self" and "not-self" in lower invertebrates.


Developmental biochemistry--a relevant endeavor. Borden Award address.


Tentacle responses of the sea anemone Anthopleura xanthogrammica to ultraviolet and visible radiations.


Hemodynamic effects of elevated cerebrospinal fluid pressure: alterations with adrenergic blockade. The cardiovascular effects of elevated cerebrospinal fluid (CSF) pressure were studied in 18 dogs, 6 in a control group, 6 after alpha adrenergic blockade, and 6 after beta adrenergic blockade. Vascular pressures did not change until CSF pressure was increased from 100 mm Hg to 200 mm Hg. In the control group, the aortic, pulmonary arterial, wedge, and right atrial pressures increased significantly. Cardiac output, heart rate, and stroke volume increased but systemic and pulmonary vascular resistances did not change. In the alpha adrenergic blockade group, vascular pressures did not increase after elevation of CSF pressure. Cardiac output increased or did not change, stroke volume increased, systemic resistance decreased, and pumonary resistance did not change. In the beta adrenergic blockade group, the vascular pressures all increased significantly when CSF pressure was elevated, but cardiac output did not change. Systemic resistance increased and pulmonary resistance decreased. Central blood volume increased in all three groups when CSF pressure was 200 mm Hg. The data suggest that a large and distinct alpha and beta adrenergic stimulus occurred when CSF pressure was increased to 200 mm Hg.


The effect of an NADH oxidase inhibitor (hydrocortisone) on polymorphonuclear leukocyte bactericidal activity. Polymorphonuclear neutrophils (PMN) from patients with chronic granulomatous disease of childhood have impaired bactericidal activity and are deficient in diphosphopyridine nucleotide, reduced form of, (NADH) oxidase. Since hydrocortisone had been shown to inhibit NADH oxidation, experiments were undertaken to determine the effect of hydrocortisone on several parameters of human PMN function. The phagocytic and bactericidal capacity of PMN with or without hydrocortisone (2.1 mM) was determined by quantitation of cell-free, cell-associated, and total bacteria. Phagocytosis of Staphylococcus aureus and several gram-negative rods was unimpaired by the presence of hydrocortisone in the media. In contrast, killing of bacteria was markedly impaired by hydrocortisone. After 30 min of incubation, there were 20-400 times as many bacteria surviving in hydrocortisone-treated PMN as in simultaneously run controls without hydrocortisone. The defect of intracellular killing noted in the presence of hydrocortisone was not related to impaired degranulation. Quantitative kinetic studies of degranulation revealed no difference in the release of granule associated acid phosphatase in hydrocortisone-treated and control PMN after phagocytosis. Electron microscopy of PMN also indicated that the presence of hydrocortisone had no effect on the extent of degranulation after phagocytosis. These observations were confirmed by studies using histochemical techniques to detect lysosomal enzymes. After phagocytosis, hydrocortisone-treated PMN demonstrated less NADH oxidase activity, oxygen consumption, and hydrogen peroxide production than postphagocytic control PMN. In addition, Nitro blue tetrazolium dye reduction was diminished in hydrocortisone-treated PMN.Thus, impairment of NADH oxidase activity in normal human PMN by hydrocortisone results in reduced intracellular killing of bacteria, diminished postphagocytic oxygen consumption, decreased ability to reduce Nitro blue tetrazolium, and decreased hydrogen peroxide production. These abnormalities are similar to those seen in the PMN of patients with chronic granulomatous disease of childhood.


Genetic control mechanisms in man and other mammals.


Biological aspects of individuality.

Biological aspects of individuality.


The immunosuppressive effects of 6-azauridine.


The current status of human heart transplantation.


The time of death.

The time of death.


Psychosomatic aspects of headache.

Psychosomatic aspects of headache.


Traumatic rupture of the duodenum.

Traumatic rupture of the duodenum.


A clinical study of a hypersensitivity pneumonitis.


Blindness due to steroid induced glaucoma.


"Increasing professional productivity".

"Increasing professional productivity".


The Illinois Regional Medical Program for heart disease, cancer and stroke.


Observation on erythema nodosum.

Observation on erythema nodosum.


Effects of pentobarbital sodium anesthesia and neurohumoral agents on the cardiac orienting reflex.


Ocular trauma.

Ocular trauma.


Biosynthesis of an O-alkyl analogue of phosphatidic acid and O-alkylglycerols via O-alkyl ketone intermediates by microsomal enzymes of Ehrlich ascites tumor.


Isolation and some properties of the triphosphopyridine nucleotide isocitrate dehydrogenase from Bacillus stearothermophilus.


Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain.


Studies on photodynamic action. I. The action on pneumococcal transforming DNA.


Undescended testes.

Undescended testes.


Riboflavin nutritional status of rats suffering from essential fatty acid deficiency.


Orthostatic hypotension during vincristine therapy.


Nomenclature of birthweight and gestational age. Suggestions of a working party of the Second European Congress of Perinatal Medicine, April, 1970.


Cytogenetic analysis of the inactivated component in transplanted mixtures of spleen cells of two different genotypes.


The role of immunoblasts in host resistance and immunotherapy of primary sarcomata.


Is atherosclerosis a disorder of intramitochondrial respiration?


Hereditary angioneurotic edema. Report of a large kindred with defect in C'1 esterase inhibitor and review of the literature.


Isolation, localization and biosynthesis of crassin acetate in Pseudoplexaura porosa (Houttuyn).


Restoration of regenerative ability in ligated stems of Tubularia in an electric field.


A comparative study of dextro-alprenolol, dextro-propranolol, and practolol in treatment of ventricular ectopic beats.


Comparison of haemodynamic effects of oxprenolol (trasicor), alprenolol (aptin), and sotalol (MJ 1999) in man.


Preliminary studies on the chemical nature of mosquito-breeding waters in Delhi.


Hereditary prolongation of QT interval . Study of two families. A syndrome has previously been recognized, which is characterized by recurrent episodes of loss of consciousness, some of which end fatally. The electrocardiogram in affected subjects shows prolongation of the QT interval. In the present study, 2 unrelated families with a total membership of 82 were investigated; 30 living subjects were examined and 20 were found to be affected. A further 14 members, 11 of whom died suddenly, were presumed from their histories to have been affected. The condition seems to be much more common, at least in South Africa, than the small number of previously reported cases would suggest. In contrast to the similar syndrome in which congenital deafness is also a feature and in which the disorder is transmitted in an autosomal recessive manner, analysis of the present data reveals an autosomal dominant inheritance with variable penetrance. The fundamental nature of the disorder remains unknown. Though treatment is generally unsatisfactory, beta-adrenergic blocking agents may be of value.


We need adequate public health protection.


Perforation of the caecum by blunt abdominal trauma.


Gas gangrene of abdominal wall after appendectomy.


Large defect on liver scan caused by extrahepatic mass.


Electroneuroprosthesis. History and forecast.


Frostbite.

Frostbite.


Cardiac catheterization, positive blood cultures and antibiotic prophylaxis.


Effect of maternal virus infections on the fetus. II.


Surgical management of Parkinsonism.

Surgical management of Parkinsonism.


Post-thymectomy autoimmune phenomena in mice. II. Morphologic observations.


Stepwise introduction of transformable penicillin resistance in Pneumococcus.


The photosynthetic apparatus of Euglena gracilis. I. Adaptation to population density change.


Intermediates of fatty acid synthesis: sites of binding to the pigeon liver fatty acid synthetase.


Biphasic effect of norepinephrine in the regulation of hepatic tyrosine transaminase activity.


Thiocyanato-indoles as energy-transfer inhibitors in photophosphorylation.


Incomplete inversion of D-leucine and D-valine.


Dental caries and the adolescent girl in Brisbane.


Medications in pulmonary insufficiency related to obstructive airway disease.


Mechanisms of release of constituents from rabbit platelets by antigen-antibody complexes and complement. II. Interaction of platelets with neutrophils.


Management of hyperkinetic behavior in children with epilepsy.


Treatment of narcolepsy.

Treatment of narcolepsy.


Blood pressure responses to stress in renal patients.


Behaviour therapy or personality therapy?


Gonadal histology in children with male pseudohermaphroditism and mixed gonadal dysgenesis.


The agalactia complex in the sow: A review.


A study of some possible mechanisms by which magnesium activates hepatic microsomal drug metabolism in vitro.


Electrophysiologic effects of bretylium tosylate on single fibers of the canine specialized conducting system and ventricle.


A health and nutrition study among Michigan Indians.


Hydroxyprolinemia: an apparently harmless familial metabolic disorder.


Personality traits and coronary heart disease: a re-examination of Ibrahim's hypothesis using longitudinal data.


Innervation and contractile response of the human ductus arteriosus.


Survival of human thyroid tissues in mice treated with antilymphocyte serum.


Biochemical observations on so-called hereditary tyrosinemia.


Block of adrenergic beta-receptors by propranolol in the treatment of thyrotoxicosis.


Effect of beta-adrenergic blockade on electrically induced repetitive ventricular responses (RVR) in the digitalized animal.


Hypoxaemia during cardiopulmonary bypass.


New tactics for hyperthyroidism: sympathetic blockade.


MMPI comparisons between parents of young emotionally disturbed and organically retarded children.


Effects of rule relaxation and system combination on classification rates in two MMPI "Cookbook" systems.


On the Enzymatic hydrolysis of FAD in spinach leaves.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 34-1970.


Cardiovascular effects of beta-receptor blocking drugs during halothane anaesthesia in man.


Experiences with cogentin in the treatment of Parkinsonism. A one-year controlled study of 94 patients.


Ultrastructural aspects of delayed hypersensitivity.


The role of nicotinamide-adenine dinucleotide phosphate-dependent malate dehydrogenase and isocitrate dehydrogenase in the supply of reduced nicotinamide-adenine dinucleotide phosphate for steroidogenesis in the superovulated rat ovary. 1. Superovulated rat ovary was found to contain high activities of NADP-malate dehydrogenase and NADP-isocitrate dehydrogenase. The activity of each enzyme was approximately four times that of glucose 6-phosphate dehydrogenase and equalled or exceeded the activities reported to be present in other mammalian tissues. Fractionation of a whole tissue homogenate of superovulated rat ovary indicated that both enzymes were exclusively cytoplasmic. The tissue was also found to contain pyruvate carboxylase (exclusively mitochondrial), NAD-malate dehydrogenase and aspartate aminotransferase (both mitochondrial and cytoplasmic) and ATP-citrate lyase (exclusively cytoplasmic). 2. The kinetic properties of glucose 6-phosphate dehydrogenase, NADP-malate dehydrogenase and NADP-isocitrate dehydrogenase were determined and compared with the whole-tissue concentrations of their substrates and NADPH; NADPH is a competitive inhibitor of all three enzymes. The concentrations of glucose 6-phosphate, malate and isocitrate in incubated tissue slices were raised at least tenfold by the addition of glucose to the incubation medium, from the values below to values above the respective K(m) values of the dehydrogenases. Glucose doubled the tissue concentration of NADPH. 3. Steroidogenesis from acetate is stimulated by glucose in slices of superovulated rat ovary incubated in vitro. It was found that this stimulatory effect of glucose can be mimicked by malate, isocitrate, lactate and pyruvate. 4. It is concluded that NADP-malate dehydrogenase or NADP-isocitrate dehydrogenase or both may play an important role in the formation of NADPH in the superovulated rat ovary. It is suggested that the stimulatory effect of glucose on steroidogenesis from acetate results from an increased rate of NADPH formation through one or both dehydrogenases, brought about by the increases in the concentrations of malate, isocitrate or both. Possible pathways involving the two enzymes are discussed.


Effect of some antihistaminic agents on the chronotropic response of adrenaline hydrochloride on isolated rat atria.


Hydrocortisone-mediated changes in the concentration of tyrosine transaminase in rat liver: an immunochemical study.


Comparative studies on the effects of ganglion-blocking and pressor agents on the microscopic appearance of the kidneys and livers of animals in hemorrhagic shock.


Effect of oxytocic preparations upon the contractility of the isolated rats uterus and the bioelectric phenomena after blocking of the beta-receptors.