Experimental Trypanosoma brucei infection in lions.


Some aspects of the surface coat formation in Trypanosoma brucei.


Coenzyme A aberration in marginally hyperoxic space capsule environments.


Clinical evaluation of neutral sodium fluoride, stannous fluoride, sodium monofluorophosphate and acidulated fluoride-phosphate denifrices.


Oral health status of independent elderly persons in London, Ontario.


Hospital emergency cases of poisonings and other injuries caused by ingestion.


A perfused teleostean gill preparation: vascular actions of neurohypophysial hormones and catecholamines.


A technique for repeated superfusion or withdrawal of fluid from the exposed cerebral cortex of a conscious animal.


Reduction of electrically-rewarded behavior by interference with monoamine synthesis.


Effect of in vitro irradiation of cells in graft-versus-host reactions.


Growth and senescence of the bone marrow stem cell pool in RFM-Un mice.


2,4-D metabolism: enzymatic conversion of chloromaleylacetic acid to succinic acid.


Effects of endotoxin on myocardial hemodynamics, performance, and metabolism during beta adrenergic blockade.


Success and failure in the NARA addiction program.


Personality factors and patterns of drug usage in college students.


On the presence of acetone in oxidized pyridine nucleotides.


Factors in successful narcotics renunciation.


Homogeneous elicited antibodies: induction, characterization, isolation, and structure.


Introduction to session on homogeneous antibodies.


The pharmacologic blockade of the circhoral mode of LH secretion in the ovariectomized rhesus monkey.


D-glucose suppression of tyrosine aminotransferase in rat-hepatoma cells grown in culture.


Induction of tyrosine aminotransferase with N 6 ,O 2 -dibutyryl adenosine 3'-5'monophosphate in rat-hepatoma cells grown in culture.


Pyridine-nucleotide transhydrogenase. 1. Isolation, purification and characterisation of the transhydrogenase from Azotobacter vinelandii.


Electron flow and cholesterol-side-chain cleavage in ovarian mitochondria.


Pyridine-nucleotide transhydrogenase. 2. Electron-microscopic studies on the transhydrogenase from Azotobacter vinelandii.


Pyridine-nucleotide transhydrogenase. 3. Effect of NADP+ on the spectral properties of transhydrogenase from Azotobacter vinelandii.


Pyridine-nucleotide transhydrogenase. 4. Studies on the reductive mechanism of transhydrogenase from Azotobacter vinelandii.


Pyridine-nucleotide transhydrogenase. 5. Kinetic studies on transhydrogenase from Azotobacter vinelandii.


Studies on nucleotide pyrophosphatases: purification & properties of an enzyme from livers of fresh water fishes (Wallago attu).


Fluorides in community programs; a study of four years of various fluorides applied topically to the teeth of children in fluoridated communities.


Bone induction in experimental periodontal bony defects in dogs with decalcified allogeneic bone matrix grafts. A preliminary study.


Some peripheral pharmacological characteristics of benzoctamine.


Release of vasoactive substances from guinea-pig lungs by slow-reacting substance c and arachidonic acid. Its blockade by nonsteroid anti-inflammatory agents.


MMPI profiles in hospitalized psychiatric patients and their families.


Transhydrogenase activity in mammalian cells in vitro: its possible physiological significance.


Cytokinesis in animal cells.

Cytokinesis in animal cells.


A model for the ecology of avian malaria.


Critical oxygen tensions in the brain.

Critical oxygen tensions in the brain.


Red-cell glucose metabolism.

Red-cell glucose metabolism.


Cerebral effects of hyperventilation.

Cerebral effects of hyperventilation.


Physician support personnel in office practice.


Juvenile generalized pustular psoriasis. A report of five cases and a review of the literature.


Effect of brain stimulation in positive and negative reinforcing regions in the rat on content of catecholamines in hypothalamus and brain.


Microsomal ( S) chemiluminescence (CL) induced by NADPH and its relation to lipid peroxidation.


The relationship between the effects of endotoxin on inducible enzymes and biosynthetic activity in rat liver.


Calibration of condenser microphones under increased atmospheric pressures.


Effect of 4-chlorophenoxyamphetamine (A-6587), d-amphetamine and 4-chloroamphetamine on brain biogenic amines and behavior in mice.


Metabolism of 5-iodo-2'deoxyuridine (IUdR) in brain and liver of dogs.


Studies on methemoglobin reductase. I. Comparative studies of diaphorases from normal and methemoglobinemic erythrocytes.


MMPI correlates of chronic drug abuse in hospitalized adolescents.


Pathway for the synthesis of fatty acids in mamalian tissues.


Localization and metabolism of drugs in the fetus.


WAIS and MMPI correlates of increasing renal failure in adult medical patients.


A single blood culture for confirmation of the diagnosis of neonatal septicemia.


Photochemical activity and structural studies of photosystems derived from chloroplast grana and stroma lamellae.


A quantitative evaluation of three blood culture systems.


Functional significance of serotonin in neuronal systems. Neuronal control of brain serotonin.


Effect of beta-blocking drug propranolol on  131 I utilization in euthyroid patients.


Emphysema: the 14th Annual Aspen Conference. Introduction to the conference.


The effect of 4-bromobenzyl isothiocyanate on the redox state of nicotinamide-adenine dinucleotides in Candida albicans.


Inhibition of calcium transport in mitochondria by  -receptor blocking substances and its reactivation by phospholipids.


Graft versus host activity of bone marrow lymphocytes.


Amino acids as putative transmitters: failure to bind to synaptic vesicles of guinea pig cerebral cortex.


Ergothioneine in the central nervous system.


Relationship of stress and activity to brain dopamine and homovanillic acid.


Effects of mutations and growth conditions on lipid synthesis in Neurospora crassa. A morphological mutant (col-2) of Neurospora, which is partially deficient in glucose-6-phosphate dehydrogenase (G-6-PD) activity and has lower levels of reduced nicotinamide adenine dinucleotide phosphate (NADPH), accumulated three-fold more triglycerides during log-phase growth than the wild-type strain. Increased lipid deposition was not found in other strains that included slow-growing morphological mutants, NADPH-deficient strains, G-6-PD-deficient mutants, wild-type revertants from col-2, and a cel, col-2 double mutant. The cel, col-2 strain was supplemented with an exogenous source of fatty acids because it cannot synthesize these lipid moieties. The observed normal lipid content of this strain suggests that the lipid deposition in col-2 on glucose is due to an overstimulation of fatty acid synthesis and not a deficiency in fatty acid breakdown. The neutral lipid levels in both wild type and col-2 were decreased to identical levels when grown on glutamate as a carbon source. This effect was not due to changes in glutamic dehydrogenase levels. The omission of citrate from the glutamate medium reduced wild-type neutral lipid levels even further, but had no effect on col-2. The variations with time in the neutral lipid levels of col-2 upon changes in these carbon sources are presented, as well as a discussion of the possible types of regulatory effects unique to the col-2 mutation which might affect fatty acid synthesis.


Summing up: some implications of the neuron as a secreting cell.


The effect of a number of drugs with different pharmacological properties upon reserpine induced hypothermia in mice.


The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.


Steady-state kinetics of mitochondrial nicotinamide nucleotide transhydrogenase. 1. The nonenergy-linked reaction.


Analytical-band centrifugation of an active enzyme-substrate complex. 2. Determination of active units of various enzymes.


Regulation of  -aminolevulinic acid synthetase by drugs and steroids in vivo and in isolated perfused rat liver.


Premorbid adjustment and affective expression in schizophrenia.


Induction and regulation of a nicotinamide adenine dinucleotide-specific 6-phosphogluconate dehydrogenase in Streptococcus faecalis. Streptococcus faecalis grown with glucose as the primary energy source contains a single, nicotinamide adenine dinucleotide phosphate (NADP)-specific 6-phosphogluconate dehydrogenase. Extracts of gluconate-adapted cells, however, exhibited 6-phosphogluconate dehydrogenase activity with either NADP or nicotinamide adenine dinucleotide (NAD). This was shown to be due to the presence of separate enzymes in gluconate-adapted cells. Although both enzymes catalyzed the oxidative decarboxylation of 6-phosphogluconate, they differed from one another with respect to their coenzyme specificity, molecular weight, pH optimum, K(m) values for substrate and coenzyme, and electrophoretic mobility in starch gels. The two enzymes also differed in their response to certain effector ligands. The NADP-linked enzyme was specifically inhibited by fructose-1,6-diphosphate, but was insensitive to adenosine triphosphate (ATP) and certain other nucleotides. The NAD-specific enzyme, in contrast, was insensitive to fructose-1,6-diphosphate, but was inhibited by ATP. The available data suggest that the NAD enzyme is involved primarily in the catabolism of gluconate, whereas the NADP enzyme appears to function in the production of reducing equivalents (NADPH) for use in various reductive biosynthetic reactions.


Genetic and biochemical properties of thymidine-dependent mutants of pneumococcus. Independently isolated thymidine-dependent strains were shown to be defective in thymidylate synthetase and mutated at separable but closely linked sites.


Events occurring near the time of synapsis during transformation in Diplococcus pneumoniae. A marker-specific and strongly temperature-dependent reaction was observed to occur at a time during transformation in Diplococcus pneumoniae after the donor deoxyribonucleic acid (DNA) had acquired single-strand properties and immediately preceding the integration of these strands into the recipient chromosome. Operationally, it was observed as the prevention of an intracellular inactivation process, also described in this paper, which is specific for low molecular weight or for damaged DNA, and which occurs if the recipient cells are held at suboptimal temperatures after the DNA has entered. Brief exposure of the cells to a higher temperature stabilized the DNA against this inactivation, in a two step process. It is the first step which has a strong temperature dependence (DeltaHdouble dagger = 70 kcal/mole, DeltaSdouble dagger = 160 entropy units), is marker specific, and which appears to be reversible. The second step is much less temperature-dependent and overlaps in time the start of integration. The enthalpy and entropy of activation are both consistent with those needed to open a loop of six to eight base pairs in a DNA duplex. It is suggested that these observations may reflect, and provide an assay for, the kinetics of synapsis, which on this model is limited in rate by the appearance of unpaired regions on the recipient duplex.


Inorganic nitrogen assimilation in yeasts: alteration in enzyme activities associated with changes in cultural conditions and growth phase. Ammonia assimilation has been investigated in four strains of Saccharomyces cerevisiae by measuring, at intervals throughout the growth cycle, the activities of several enzymes concerned with inorganic ammonia assimilation. Enzyme activities in extracts of cells were compared after growth in complete and defined media. The effect of shift from growth in a complete to growth in a defined medium (and the reverse) was also determined. The absence of aspartase (EC 4.3.1.1, l-aspartate-ammonia lyase) activity, the low specific activities of alanine dehydrogenase, glutamine synthetase [EC 6.3.1.2, l-glutamate-ammonia ligase (ADP)], and the marked increase in activity of the nicotinamide adenine dinucleotide phosphate-linked glutamate dehydrogenase (NADP-GDH) [EC 1.4.1.4, l-glutamate:NADP-oxidoreductase (deaminating)] during the early stages of growth support the conclusion that yeasts assimilate ammonia primarily via glutamate. The NADP-GDH showed a rapid increase in activity just before the initiation of exponential growth, reached a maximum at the mid-exponential stage, and then gradually declined in activity in the stationary phase. The NADP-GDH reached a higher level of activity when the yeasts were grown on the defined medium as compared with complete medium. The nicotinamide adenine dinucleotide-linked glutamate dehydrogenase (NAD-GDH) [EC 1.4.1.2, l-glutamate:NAD-oxidoreductase (deaminating)] showed only slight increases in activity during the exponential phase of growth. There was an inverse relationship in that the NADP-GDH increased in activity as the NAD-GDH decreased. The NAD-GDH activity was higher after growth on the complete medium. The glutamate-oxaloacetate transaminase (EC 2.6.1.1. l-aspartate:2-oxoglutarate aminotransferase) activity rose and fell in parallel with the NADP-GDH, although its specific activity was somewhat lower. Although other ammonia-assimilatory enzymes were demonstrable, it seems unlikely that their combined activities could account for the remainder of the ammonia-assimilatory capacity not accounted for by the NADP-GDH. The ability of aspartate to serve as effectively as glutamate as the sole source of nitrogen for the growth of yeast apparently resides in their ability to utilize aspartate for amino acid biosynthesis via transamination.


Enzymatic basis for differentiation of Rhizobium into fast- and slow-growing groups. Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and other enzymes related to carbohydrate metabolism were studied in rhizobia. A nicotinamide adenine dinucleotide phosphate-6-phosphogluconate dehydrogenase was detected in strains of the fast-growing group of Rhizobium but not in strains of the slow-growing group. An enzymatic differentiation of rhizobia was established.


A profile sheet for the clinical interpretation of the Holtzman Inkblot Technique.


Nutritional studies of Rickettsia guintana: nature of the hematin requirement. Rickettsia quintana grew in a liquid medium consisting of a brain-heart infusion base supplemented with starch and hematin. The growth requirement for hematin could not be substituted by compounds of known catalytic activity for H(2)O(2), viz., catalase, potassium pyruvate, or charcoal, or by the reducing compounds sodium sulfite and sodium thioglycollate. R. quintana was catalase-negative, but no H(2)O(2) production could be demonstrated by the catalase-aminotriazole technique. A minimum inoculum giving 10(5) cells/ml was required to initiate growth. The generation time at 33 C was 10 hr. The temperature range for growth was 28 to 37 C. Growth was enhanced when succinate or glutamate was added as energy source.


Rorschach anatomy response correlates in rehabilitation failure subjects.


Utility of the Mini-Mult in a child guidance clinic setting.


Fatal poisoning involving methapyrilene.


Use of virus recombinants in the analysis of influenza virus antigens.


Analysis of antigenic and biological properties of influenza B virus strains, isolated in Leningrad in 1955-1967.


Effects of some overlay components on plaque number and plaque size of Tahyńa virus in GMK cells.


Effects of influenza virus infection on the chromosomal apparatus of cultured cells.


The use of organ cultures for propagation of polio and infectious canine hepatitis viruses.


Virulence of Tahyna virus in mice and its relation to thermosensitivity and character of plaque population markers.


Study of the antigenic structure of coxiella burneti. IX. Competition of two main antigens in experiments on white mice.


Lethal herpetic infection of rabbits after virus administration into the pulp chamber of incisors.


Endonuclease activities of myxo- and paramyxoviruses.


The use of indirect fluorescent antibody technique in studies on the reproduction of rhinoviruses and for the detection of rhinoviral antigen in materials from patients with acute respiratory diseases and conjunctivitides.


Oral infection of newborn guinea pigs with herpes simplex virus type 1.


Double-stranded f 2  phage RNA as interferon inducer.


An introduction to immunosuppressants.

An introduction to immunosuppressants.


The "long loop vas" orchidopexy for the high undescended testis.


Smallpox and smallpox vaccination policy.


The effect of sterol carrier protein on squalene synthesis.


The kinetics of imino acid accumulation in the D-amino acid oxidase reaction.


Chain elongation of fatty acids by cell-free extracts of epidermis from pea leaves (pisum sativum).


Glucocorticoids: competitive inhibition of glucose transport.


The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen.


Decreased availability of hepatic NADPH in stressed mice.


Role of glutamine synthetase in the repression of bacterial sporulation.


Effects of propranolol on several physiological responses during orthostatic and exercise stress in healthy male subjects.


Biochemical basis of heart function. IV. Energy metabolism and calcium transport in hearts of vitamin E deficient rats.


A lengthened Mini: the Midi-Mult.

A lengthened Mini: the Midi-Mult.


Relationships among patients' emotional problems, neurologists' judgments, and psychological tests of brain dysfunction.


A validation of the psychotic inpatient profile.


The repression sensitization scale: normative age and sex data on 30,000 medical patients.


Cytomorphometry of developing rat liver and its application to enzymic differentiation. Quantitative stereological methods have been adapted for the measurement of the volume of liver attributable to parenchymal, hematopoietic, and Kupffer cells and for the measurement of the relative and absolute number (per unit volume) of these cell types and the mean volume of the parenchymal cell. These morphological parameters are the main ones for interpreting the biochemical differentiation of liver. Quantitative changes in these parameters, in rat liver between the 15th day of gestation and adult life, are presented. Despite the large number of hematopoietic cells, the parenchymal cells fill more than half of the liver volume between the 15th and 18th days of gestation and 0.85 of the liver volume at term. The fraction of liver volume occupied by Kupffer cells is never more than 0.02; the number of Kupffer cells per cubic centimeter increases less than twofold between fetal and adult life. The mean volume of individual parenchymal cells undergoes a threefold rise during late fetal life, declines in the neonatal period, and doubles between the 12th and 28th postnatal days. With the morphometric data obtained, it is impossible to convert enzyme concentrations (units per gram, determined in homogenates of whole liver) to enzyme amounts per unit volume of parenchymal or hematopoietic tissue or per individual cell of either type. In late fetal liver, only rises in enzyme concentration less than twofold may be attributed to the enrichment of parenchymal tissue at the expense of hematopoietic elements. The sudden upsurge, by more than twofold, of hepatic enzymes of the late fetal cluster (and also of the neonatal and late suckling cluster) reflects rises per parenchymal mass and per parenchymal cell. Thyroxine and glucagon, the administration of which to fetal rats promotes enzyme differentiation in liver, are without appreciable effect on the cytological parameters studied. Hydrocortisone accelerates the involution of hematopoietic tissue in fetal liver. Enzymes that are diminished by prenatal injection of hydrocortisone may be concentrated in hematopoietic cells.


Characteristics of hospitalized patients who produce the "floating" MMPI profiles.


MMPI items for invasion of privacy studies.


The veteran NP patient: past and present.


Glutamic acid metabolism in rat retina during postnatal growth.


-Receptor antagonists in angina pectoris.


Regional myocardial blood flow, ischemia and antianginal drugs.


Studies on an epidemic of Japanese encephalitis in the northern region of Thailand in 1969 and 1970.


Graft-versus-host reactions and the viral induction of mouse lymphoma.


Development of neoplasia and karyotype analysis in mice with graft-versus-host reaction.


The immunocapacity of the AKR mouse.

The immunocapacity of the AKR mouse.


The role of glutamine in the oxidative metabolism of malignant cells.


Microspectrophotometric study of histoenzymic reactions in rat epidermis subjected to 0-5 Mrads of deuteron radiation.


Lessons in promoting preventive dentistry.


The effect of the anaesthetics sodium pentobarbitone, urethane and ether on enzyme induction in neonatal rat liver.


Effect of school water fluoridation on dental caries: final results in Elk Lake, Pa, after 12 years.


Ultraviolet spectrophotometric characterization of a glutamate dehydrogenase-reduced coenzyme- -ketoglutarate complex.


20 -hydroxysteroid dehydrogenase of porcine testes.


Localization of the reduced nicotinamide adenine dinucleotide phosphate:   4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate.


Caries experience of school children in West Hartlepool, a natural fluoride area.


Chemical and humoral regulation of blood flow through the precapillary sphincter.


Doctor, there's a puck in my mouth.

Doctor, there's a puck in my mouth.


Studies on a coupled enzyme assay for rate measurements of ATPase reactions.


Nippostrongylus brasiliensis: histamine and 5-hydroxytryptamine inhibition and worm expulsion.


The response of haemopoietic colony-forming units to single and split doses of  -rays of D-T neutrons.


Changes in beta-oxidation and related enzymes during the life cycle of Strongyloides ratti (Nematoda).


On the nature and measurement of antigenic strength.


Studies on neurotransmission mechanisms in the rat and guinea-pig vas deferens.


Treatment of the dry eye and related problems.


Effects of vasoactive agents on isolated human umbilical arteries and veins.


Blood glucose, growth hormone, and cortisol levels after hypothalamic stimulation.


Neurohumoral substances released from hypothalamus of the monkey during hunger and satiety.


Problems of the closed technique of intrauterine fetal transfusion.


NADP + -specific isocitrate dehydrogenase of Escherichia coli. I. Purification and characterization.


Purification and properties of an NADP + -dependent glycerol dehydrogenase from rabbit skeletal muscle.


Electron transport to nitrogenase in Azotobacter chroococcum. Purification and some properties of NADH dehydrogenase.


Cholinesterase activity of the hypothalamo-hypophysial neurosecretory system in rats during the ontogenetic development.


Tentacular and oral-disc regeneration in the sea anemone, Aiptasia diaphana. 3. Autoradiographic analysis of patterns of tritiated thymidine uptake.


Our rich tropical heritage.

Our rich tropical heritage.


Studies on transmission of Bancroftian filariasis in North-Eastern Tanzania.


Mosquitoes of British Honduras, with some comments on malaria, and on arbovirus antibodies in man and equines.


The ANA position on physicians's assistants.


Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis.


Steroid metabolism in rats given (1- 2 H 2 ) ethanol. Biosynthesis of bile acids and reduction of 3-keto-5 -cholanoic acid.


The effects on airways conductance of alpha-adrenergic stimulation and blocking.


Central and peripheral adrenergic blocking actions of LSD and BOL.


Beta-receptor blocking and cardiodepressant actions of 2-nitrilophenoxypropanolamines.


Alpha and beta adrenergic receptors in amygdala: reciprocal inhibitors and facilitators of punished operant behavior.


Effect of several anticonvulsant drugs and procainamide against ouabain-induced cardiac arrhythmias in rabbits.


Hypothermia induced by intraventricular administration of 6-hydroxydopamine in rats.


Toxicological and pharmacological studies on sea anemone, Calliactis polypus (Hormathiidae).


Medical management of patients with angina pectoris.


Travelling.

Travelling.


The isolation and some properties of an enzyme system which catalyzes the degradation of  -nitropropionic acid.


Coupled oxidoreductase activity of horse liver alcohol dehydrogenase.


Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.


Incorporation of radioactive- -aminolevulinic acid into microsomal cytochrome P 450 : selective breakdown of the hemoprotein by allylisopropylacetamide and carbon tetrachloride.


Inhibition of protein synthesis in brain subcellular fractions by the convulsant allylglycine.


Evidence for the presence of  -adrenoceptors in the central thermoregulatory mechanism of rabbits. 1. The effects of intracerebroventricular administration of some alpha- and beta-adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated.2. Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active.3. The noradrenaline response was blocked by alpha-adrenoceptor blocking agents while beta-adrenoceptor antagonists had no effect.4. alpha-Methyl-noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline.5. The possible presence of alpha-adrenoceptors in the central thermoregulatory mechanisms is suggested.


Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and  -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.


Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine. 1. Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25-30% after 30 minutes.2. The effect of several receptor blocking drugs on the amphetamine-induced cerebral glycogenolysis was studied.3. DL-Propranolol (0.25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine.4. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine-induced glycogenolysis.5. D-Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.6. It is concluded that amphetamine-induced glycogenolysis in the mouse brain may be mediated through a beta-adrenoceptor.


Effects of adrenoceptor blocking agents on body temperature. 1. The effect on rectal temperature of adrenoceptor blocking agents, injected through a cannula chronically implanted into a lateral cerebral ventricle, was examined in unanaesthetized rabbits, cats and rats, kept at room temperature (19-22 degrees C).2. In rabbits, the alpha-adrenoceptor blocking agent phenoxybenzamine (50 or 100 mug) produced marked hypothermia when injected intraventricularly but not when injected intravenously. In some rabbits as little as 1 mug was effective on intraventricular injection. Phentolamine and ergotamine, the other alpha-adrenoceptor blocking agents examined, had a much weaker hypothermic action when injected intraventricularly, whereas the beta-adrenoceptor blocking agents propranolol, pronethalol and Trasicor had no effect.3. In rabbits in which the noradrenaline stores of the hypothalamus were depleted by intraventricular injections of reserpine, the hypothermic effect of phenoxybenzamine was abolished and remained abolished for a few days.4. In cats, an intraventricular injection of phenoxybenzamine (200 mug) produced long-lasting hyperthermia, but not in all cats, and only with the first, or the first two or three injections. Injected intraperitoneally, this dose had no effect on temperature. Phentolamine (100 or 200 mug) had a very weak hyperthermic effect and phentolamine (500 mug), a hypothermic effect, but only on intraventricular injection, whereas ergotamine (100 and 200 mug) had a weak hyperthermic effect both on intraventricular and intraperitoneal injection. Propranolol and Trasicor had no effect on temperature when injected intraventricularly.5. In rats, phenoxybenzamine (5 or 20 mug) produced long-lasting hypothermia on intraventricular injection.6. Some of the temperature effects produced by intraventricular injections of the alpha-adrenoceptor blocking agents are explained on the assumption that they prevent the effect on temperature produced by a continuous release of noradrenaline from adrenergic neurones innervating the anterior hypothalamus.


Effects of isoxazolium cations on some isolated muscle preparations. 1. The quaternary ammonium compound, N,t-butyl-5-methyl isoxazolium perchlorate (BIP), an anionic group reagent, initially causes contractions of the rat phrenic-nerve diaphragm, guinea-pig ileum and rabbit aortic strip preparations in vitro.2. In addition, the drug produces an irreversible block of indirectly elicited twitch responses in the diaphragm and of contractions induced by acetylcholine, methylfurmethide, dimethyl-phenylpiperazinium, 5-hydroxytryptamine (5-HT), histamine, angiotensin and pilocarpine in the ileum, while direct electrical stimulation of the diaphragm and contractions of the ileum to Ba and K ions are relatively unaffected.3. BIP is also an irreversible inhibitor of acetylcholinesterase but not of butyrylcholinesterase.4. On rabbit aortic strip preparations, responses to histamine, noradrenaline and 5-HT were differentially sensitive to irreversible blockade by BIP.5. Diphenhydramine, used in conditions which gave complete protection of the histamine response to irreversible block by dibenamine, did not protect against the blocking action of BIP but increased the blockade.6. These results suggest that BIP reacts covalently with anionic groups which mediate receptor initiated stimuli. The isoxazolium group may be useful in conferring irreversible properties by its substitution in drug molecules for the pyrrole or pyrrolidine group.


Competition of antigens during induction of low zone tolerance.


Influence of syngeneic thymus and bone marrow transplants on the intensity of the graft-versus-host reaction.


Effect of M & B 17803A, a new  -adrenoceptor blocking agent, on the cardiovascular responses to tilting and to isoprenaline in man. 1. DL-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M & B 17803A) was given to four healthy volunteers in single oral doses of up to 300 mg. There were no subjective effects and no significant alterations in the heart rate, systolic and diastolic blood pressure in the seated position or in the forced expiratory volume or in the electrocardiogram within 6 h of the dose. There were no abnormalities in haematological tests and estimations of the serum glutamyloxaloacetic transaminase.2. Oral doses of both M & B 17803A and propranolol inhibited the increase in heart rate which occurs on tilting from the supine to the 80 degrees head up position. The results suggest that the degree of beta-adrenoceptor blockade produced by M & B 17803A (100 and 300 mg) is comparable to that of propranolol (10 and 40 mg) respectively. Propranolol is 7.5-10.0 times as potent as M & B 17803A when compared by this method. There were no significant changes in the systolic or diastolic blood pressure after any of the treatments, in either of the positions studied.3. M & B 17803A was also effective in inhibiting the increase in heart rate produced by the intravenous infusion of isoprenaline and in two subjects the degree of beta-adrenoceptor blockade produced by M & B 17803A (300 mg) was comparable to that of propranolol (40 mg). M & B 17803A is a competitive beta-adrenoceptor blocking agent and the duration of the pharmacological activity of both M & B 17803A and propranolol appeared to be very similar as assessed by this method.4. In separate experiments with small oral doses of M & B 17803A no evidence of a selective action on myocardial beta-adrenoceptors was obtained from the study of changes in heart rate and diastolic blood pressure (sphygmomanometric recording).


Effects of imipramine, desipramine and monoamine oxidase inhibitors on the metabolism and psychomotor stimulant actions of d-amphetamine in mice.


Analysis of the actions of alprenolol and propranolol on the beta adrenergic receptors controlling heart rate in the anaesthetized cat.


Pyrrolizidine aminoalcohols: indirect cholinomimetic activity in guinea-pig ileum.


Antioxytocin activity of propranolol, INPEA and their optical isomers on the isolated rat uterus.


The glutamate dehydrogenase of Plasmodium lophurae (avian malaria).


Studies on the mosquitoes of North Arcot district, Madras State, India. 2. Biting cycles and behavior on human and bovine baits at two villages.


Studies on the mosquitoes of North Arcot district, Madras State, India. 1. Seasonal densities.


Effects of ultra-low volume applications of malathion in Hale County, Texas. IV. Arbovirus studies.


Comparative anatomy of the mandible of the fourth instar mosquito larva (Diptera: Culicidae).


Parous rates in Wisconsin mosquito populations.


Studies on the gonotrophic cycle of Anopheles minimus flavirostris and the application of physiological age grading technique on the same species.


Nurse, extended nurse, physician's assistant?


Sympathetic ganglionectomy for treatment of long-QT-interval syndrome.


Influence of bloodmeals from different donors on the infection rates of Trypanosoma brucei in Glossina.


The transmission pattern of smallpox in Eastern Mali.


Some aspects of cattle raising under prophylactic treatment against trypanosomiasis on the Mkwaja Ranch, Tanzania.


Ultrastructural differentiation of the midgut epithelium in female Aedes aegypti (L.) (Insecta, Diptera) imagines.


The development of immunohistochemistry.


The definition and application of evaluation techniques as a guide for the improvement of fluorescent antibody reagents.


Experience with pericyazine in profoundly and severely retarded children. The effectiveness of pericyazine in severe behavioural disorders was evaluated in 15 profoundly and severely retarded children. Pericyazine provided significant improvement in such parameters as co-operation, temper, purposeless activities, hyperactivity, communication and mood. It proved to be statistically superior to the minor tranquillizers in improving co-operation and helpfulness, temper, mood, the understanding of commands and table manners, and in reducing self-abusiveness and abusiveness to staff. The safety of this agent was confirmed and photosensitivity was not found to be associated with its use.


A cell-wall deficient form of the pneumococcus in a case of pneumonia.


A clinical trial of folic acid in Parkinson's disease.


A comparison of cardiovascular and oviduct beta adrenergic receptors.


Stimulation of adrenal corticosteroid secretion by hypercalcemia in the dog.


Minimal alveolar concentration (MAC) and dose-response curves in anesthesia.


Synthesis and pharmacological properties of a series of 2-piperidino alkanol derivatives.


Conversion of retinyl methyl ether into retinol in the rat in vitro.


Role of adrenergic neurone blockade in the hypotensive action of propranolol. 1. Propranolol, in doses of 25-100 mug/kg, blocks contractions of the nictitating membrane to nerve stimulation but not to injected noradrenaline.2. This adrenergic neurone blocking action of propranolol is antagonized by amphetamine.3. It is also reversed by raising the dose of propranolol to amounts exceeding 0.5 mg/kg.4. Still larger amounts potentiate the responses of the nictitating membrane to both submaximal stimulation of the cervical sympathetic nerve and to injected noradrenaline.5. The (+) isomer of propranolol produced adrenergic nerve blockade and some degree of hypotension without blocking cardiac beta-adrenoceptors.6. The relevance of adrenergic neurone blockade to the hypotensive effect of propranolol is discussed.


Further studies on histamine catabolism in vivo. 1. Histamine catabolism in vivo was studied in mice and rats; tissues from animals killed 2.5 min after intravenous injection of (14)C-histamine were assayed for (14)C-histamine and total (14)C. Aminoguanidine, a diamine oxidase inhibitor, and methylhistamine, an inhibitor of the histamine methylating enzyme, were used to evaluate the roles of these enzymes in individual tissues.2. Mouse liver and lung appeared to catabolize exogenous histamine rapidly and completely by methylation. In vivo histamine methylating activity was also found in mouse muscle, heart, kidney and lymph node, but not in stomach or intestine.3. In rats (14)C-histamine was inactivated more slowly than in mice. Catabolism was most rapid in intestine where both diamine oxidase and methylating activities were found. Liver had only diamine oxidase activity. Heart showed no catabolism but had extraordinary ability to extract (14)C-histamine from blood.4. The in vivo evaluation of histamine methylation by individual mouse and rat tissues agrees closely with in vitro findings by another laboratory.5. Aminoguanidine reduced uptake of blood (14)C-histamine by some tissues presumably by occupying sites where histamine is normally bound.6. The marked differences between tissues of mice and rats in destroying (14)C-histamine support earlier evidence that there is no apparent relationship between histamine catabolism and function.7. Urine from mice with both major catabolic pathways blocked showed evidence of an abnormal excretory product of (14)C-histamine. Paper chromatograms of urine of male and female mice showed no evidence of a sex difference in catabolism of injected (14)C-histamine.8. A procedure which may permit evaluating contributions of individual tissues to histamine formation in vivo is presented.9. Pretreatment of mice with antihistamines, or with a histamine analogue, betahistine, did not significantly affect the rate of in vivo(14)C-histamine inactivation.


Resistance to  -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths). 1. Resistance to isoprenaline has been produced in man and dog by prolonged exposure to the same, or the pharmacologically similar compounds, terbutaline and isoetharine.2. In guinea-pigs, pretreatment with these agents increases asthma mortality provoked by histamine which suggests that this resistance may reduce the effectiveness of endogenous sympathetic drive to the bronchi.3. Possible mechanisms by which the asthma death rate could be increased are discussed.4. It is suggested that a drug-induced cross resistance to endogenous sympathetic stimulation could have led to a deterioration of the asthmatic state in patients using the pressurized aerosols of sympathomimetic bronchodilators and that this might account for the rise in asthma death rate.


Effects of  -adrenoreceptor blocking drugs on isolated skeletal and cardiac muscle.


Attempt to assess the selectivity of  -adrenoceptive blocking agents towards the effects of electrical stimulation of the spinal cord on different organs.


Pharmacology of M & B 17803A in man and dog.


Human pharmacology of indoramin.

Human pharmacology of indoramin.


Intracellular enzymes and  -ketolic steroids of the gonads in Xenopus laevis Daud.


Oxidative enzymes and  -ketolic steroids in the interrenal cells of the South African clawed toad Xenopus laevis Daud.


Comparison of the symptomatic, electrocardiographic and haemodynamic effects of acute and long term  -blockade in angina pectoris.


An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. Earlier experiments have shown that significantly more endogenously generated NADPH is available for reduction of corticosterone in liver homogenates from C57BL/10 male mice than in those from the DBA/2 strain. To test the effect of this interstrain difference upon a representative NADPH-requiring biosynthetic pathway in vitro, the biosynthesis of cholesterol from mevalonic acid was studied in homogenates of livers from the two strains of mice, with and without addition of an NADPH-generating system. The incorporation of mevalonic acid into cholesterol in homogenates from the C57BL/10 strain is little affected by omission of the NADPH-generating system, but in the DBA/2 strain, addition of an NADPH-generating system is necessary to elevate the level of cholesterol synthesis to that of the C57BL/10 strain. Without this addition, the DBA/2 homogenate mainly produces lanosterol and other precursors of cholesterol which require NADPH for their further metabolism.


Structural parameters determining cholinergic and anticholinergic activities in a series of 1,3-dioxolanes.


-Adrenergic blocking agents. 12. Heterocyclic compounds related to propranolol.


Antibacterial activity of 6-(5-membered heteroarylacetamido)penicillanic acids.


Nasal secretion in the cat.

Nasal secretion in the cat.


Abortion.

Abortion.


Central neural regulation by adrenergic nerves of the daily rhythm in hepatic tyrosine transaminase activity. 1. In adrenalectomized fasted rats transection of the spinal cord at C7-C8 or placement of bilateral electrolytic lesions in the lateral hypothalamus when performed in the morning interrupted the daily rhythm of hepatic tyrosine transaminase by elevating low (AM) enzyme activities to high (PM) levels; lesions placed in PM did not affect the late afternoon rise in enzyme activity.2. Bilateral thalamic lesions had no affect on enzyme activity.3. The activity of hepatic catechol-O-methyl transferase was unaffected by hypothalamic lesions.4. The lesion-evoked rise of tyrosine transaminase activity was abolished by exogenously administered norepinephrine.5. Cycloheximide blocked the rise of tyrosine transaminase activity caused by hypothalamic lesions.6. The results suggest that rhythmic activity of sympathetic nerves governed by lateral hypothalamus contribute to regulation of the daily rhythm in tyrosine transaminase by regulating the release of norepinephrine peripherally; norepinephrine may block the daily rise of enzyme by interfering with protein synthesis, possibly of new enzyme, by competing with pyridoxal co-factor.7. It is proposed that alternating activity of sympathetic-adrenergic and vagal-cholinergic nerves to liver, controlled by the C.N.S., contribute to rhythmic activity of hepatic tyrosine transaminase.


Peristalsis in the rabbit distal colon.

Peristalsis in the rabbit distal colon. 1. The motility of the distal colon of the rabbit has been examined by the conventional Trendelenburg method and by an isometric, isovolumic modification of this method.2. The colon shows a range of movements, and tetrodotoxin and cold-storage have been used in an attempt to differentiate between myogenic and neurally integrated activities.3. The observable myogenic movements are pendulum movements, ;tone rings' and ;tone waves'; the last of these can be weakly propulsive. The rabbit colon also shows a neurally organized and powerfully propulsive movement which corresponds to the peristaltic wave.4. The implication of a role for nervous structures in the propulsive activity of the rabbit distal colon is at variance with the view of Lee (1960).5. The myenteric reflex arc in the colon has been examined pharmacologically. Cholinergic neural transmission has been implicated at the ganglionic-synaptic and neuroeffector junctions, but additional noncholinergic mechanisms of chemical transmission have not been excluded.


Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?


Histological changes in mosquito flight muscle fibres associated with parasitization by filarial larvae.


Humoral transmission of sleep, V. New evidence from production of pure sleep hemodialysate.


Non-cardiac morphological stigmata of congenital heart disease.


Synergy of antihost antiserum with donor spleen cells in the graft-versus-host reaction.


Relative sensitivity of nonimmunocompetent thymus cells to the action of antiserum to thymus ribosomal fraction.


Direct and beta-adrenoreceptor blocking effects of 4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB-46) on myocardial hemodynamics.


Unbalanced production of reduced nicotinamide-adenine dinucleotide phosphate in rheumatoid synovial lining cells.


Mechanism of inhibition of microsomal mixed-function oxidation by the gut-contents inhibitor of the southern armyworm (Prodenia eridania). A potent inhibitor of microsomal mixed-function oxidation reactions in insects had previously been isolated and partially purified from the gut contents of Prodenia eridania and shown to be associated with proteinase activity. Incubation of rat liver microsomal fraction with low concentrations of this inhibitor led to solubilization of NADPH-cytochrome c reductase, which was paralleled by the inactivation of reduction of cytochrome P-450 by NADPH and by the inhibition of NADPH-linked benzo[3,4]pyrene hydroxylation and aminopyrine demethylation. There was little or no effect on cytochromes b(5) and P-450, nor was the capacity of the latter catalyst to combine with exogenous substrates decreased. Contrary to the findings with NADPH, preincubation of microsomal fraction with the inhibitor did not cause a significant decrease in the rate of cytochrome P-450 reduction by NADH, supporting the assumption that different catalysts are involved in the electron transfer from NADH and NADPH to cytochrome P-450. The findings indicate the importance of taking the possible presence of endogenous inhibitors into consideration when evaluating low or absent mixed-function oxidation activities found in insect systems in vitro.


Investigation of the metabolic oxidation of acenaphthen-1-ol.


Syntheses and antibacterial activities of penicillins from (+)- and ( )- -amino-4-isothiazolylacetic acids.


Preliminary studies of the effects of DMSO on histochemical reactions.


MMPI changes in hospitalized alcoholics. A second study.


Congenital methemoglobinemia: the result of age-dependent decay of methemoglobin reductase.


The effect of cortisone acetate on lysosomal enzyme levels in rat liver.


Congenital heart disease in male and female subjects with somatic features of Turner's syndrome and normal sex chromosomes (Ullrich's and related syndromes).


Haemodynamic effects of practolol.

Haemodynamic effects of practolol.


Chemical mediators of immediate hypersensitivity.


Psychopathology associated with myasthenia gravis and its treatment by psychotherapeutically oriented group counseling.


The effect of chronic adrenergic receptor blockade on plasma renin activity in man.


Biopharmaceutical studies on aminoethanesulfonylpiperidine and related compounds. I. Absorption, excretion, metabolism, and some pharmacological activities.


The hormonal response to HCG stimulation in male children and adolescents.


Synthesis of 2-dialkylaminomethyl-1,4-benzoxathians.


Trans-synaptic regulation of tyrosine hydroxylase activity in adrenergic neurones: effect of potassium concentration on cultured sympathetic ganglia.


Factors involved in the inhibition of drug metabolism by (-)-emetine.


Poly- -hydroxybutyrate biosynthesis and the regulation of glucose metabolism in Azotobacter beijerinckii. Azotobacter beijerinckii possesses the enzymes of both the Entner-Doudoroff and the oxidative pentose phosphate cycle pathways of glucose catabolism and both pathways are subject to feedback inhibition by products of glucose oxidation. The allosteric glucose 6-phosphate dehydrogenase utilizes both NADP(+) and NAD(+) as electron acceptors and is inhibited by ATP, ADP, NADH and NADPH. 6-Phosphogluconate dehydrogenase (NADP-specific) is unaffected by adenosine nucleotides but is strongly inhibited by NADH and NADPH. The formation of pyruvate and glyceraldehyde 3-phosphate from 6-phosphogluconate by the action of the Entner-Doudoroff enzymes is inhibited by ATP, citrate, isocitrate and cis-aconitate. Glyceraldehyde 3-phosphate dehydrogenase is unaffected by adenosine and nicotinamide nucleotides but the enzyme is non-specific with respect to NADP and NAD. Citrate synthase is strongly inhibited by NADH and the inhibition is reversed by the addition of AMP. Isocitrate dehydrogenase, a highly active NADP-specific enzyme, is inhibited by NADPH, NADH, ATP and by high concentrations of NADP(+). These findings are discussed in relation to the massive synthesis of poly-beta-hydroxybutyrate that occurs under certain nutritional conditions. We propose that synthesis of this reserve material, to the extent of 70% of the dry weight of the organism, serves as an electron and carbon ;sink' when conditions prevail that would otherwise inhibit nitrogen fixation and growth.


Metabolic activation of alkylphenyl phosphates.


Heterotopic liver transplantation. I. Postoperative course and histological feature of the canine auxiliary homograft.


Tumour induction by cell-free extracts derived from mice with graft versus host disease.


Evidence for conversion of heteroduplex transforming DNAs to homoduplexes by recipient pneumococcal cells (DNA strand resolution-DNA repair-bacterial transformation-genetic recombination). Heteroduplex molecules of pneumococcal DNA, prepared by cross-annealing resolved complementary strands, have been used as donors in transformation. A number of pairs of genetic markers are situated exclusively in the trans configuration in these heteroduplexes. Insertion of two markers from trans configuration into opposite DNA strands of a recipient genome should result in their segregation after one replication cycle. As a consequence, doubly transformed progeny would not appear, or would be markedly decreased. Contrary to these expectations, transformations with the heteroduplex DNAs give as many doubly transformed progeny for unlinked marker pairs as do homoduplex DNAs. For a pair of markers that normally are weakly linked, the frequencies of cotransfer are actually greater than those observed for a mixture of two singly marked homoduplex DNAs. These results lead to the conclusion that the heteroduplex DNAs are acted upon by repair enzymes of recipient cells so that markers introduced in the trans configuration are frequently converted to the cis configuration, either before or during integration. The efficiency of this conversion suggests that the repair and integration processes may be intimately connected. It is also concluded that complete breakdown of one strand of donor heteroduplex DNA does not occur during DNA uptake by recipient cells.


Biochemical pharmacology of catecholamines and its clinical implications.


Mechanisms of azide ataxia--result of a chemical cerebellar decortication.


Brain uptake of metabolites and drugs following carotid arterial injections.


The reaction of nitro and azo compounds by housefly microsomes.


Effect of pre-irradiation of transplanted bone marrow cells on the survival of lethally irradiated recipient mice.


Studies on the mosquitoes of North Arcot District, Madras State, India. 5. Breeding places of the Culex vishnui group of species.


Studies on the mosquitoes of North Arcot District, Madras State, India. 6. Seasonal prevalence of the Culex vishnui group of species.


Impaired intravascular clearance of pneumococcus type-3 following splenectomy.


The soft-tissue and bone changes in frostbite injuries.


An inguinal approach to equine cryptorchidectomy.


Nuclease activity of large RNA viruses.

Nuclease activity of large RNA viruses.


Growth of herpes simplex virus in cultures of dissociated human nervous tissue.


Observations on neural spread of herpes simplex virus in suckling mice. An electron microscopic study.


Soluble antigens of sheep pox and goat pox viruses as determined by immunodiffusion in agar gel.


Effect of protective substances on inactivation of bacteriophages by hydroxylamine.


Application of permeation chromatography on controlled-pore glass in the purification of plant viruses.


Agar gel precipitation reaction with respiratory-syncytial virus antigen.


Effect of juices from Araliaceae plants on the infectivity of phytopathogenic viruses.


Enhanced virulence of the vaccine strain E of Rickettsia prowazeke on passaging in white mice and guinea pigs.


Pathogenesis of vaccine strains of measles virus in suckling hamsters.


Concerning the question of infraforms in Rickettsia prowazeki.


Concentration of influenza and other respiratory viruses in nasopharyngeal washings by two-phase aqueous polymer systems.


Isolation of tick-borne encephalitis virus from the brain of a sick dog in Switzerland.


Protection of newborn mice during neonatal immunological unresponsiveness from a lethal virus infection by injection of statolon.


Arbovirus plaques in mosquito cell monolayers.


Interaction between hepatitis and animal leukosis viruses.


Simplified plaque assay of Tahyna virus on GMK cells.


Isolation of Yaba 1 arbovirus in Czechoslovakia.


Influence of sympathetic nerve stimulation on pulmonary hydraulic input power.


Advances in dermatology in the last 25 years.


Pentose phosphate shunt and gastric acid secretion in the rat.


Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chickens.


Salazopyrin (azulfidine) treatment in scleroderma.


A winter outbreak of ECHO virus type 9 meningitis in Jerusalem, with cases of a simultaneous mixed pneumococcal-viral infection.


Studies on thymus function. 3. Duration of thymic function. The immune functions of neonatally thymectomized C3Hf mice exposed only temporarily to thymus function show a progressive decay with time in the absence of the thymus. The immune responses studied at different ages in the range of 100-600 days were: first-set rejection of H-2-compatible and incompatible skin allografts, second-set rejection of skin allografts, capacity of spleen cells to produce graft-versus-host reactions in F(1) hybrids, resistance to infection with mouse hepatitis virus, and response of spleen cells to phytohemagglutinin in vitro. These long-term studies had the purpose of determining the duration of the restoration induced by thymus function when the mice were exposed only temporarily to it. Different models were used but the two basic ones were: (a) mice grafted intraperitoneally at 15 days of age with a syngeneic thymus that was removed surgically at 10, 20, or 30 days after grafting, and (b) mice grafted at 15 days of age with allogeneic strain A thymoma or C57BL thymus, these representing situations in which there is spontaneous rejection of the restoring graft. In all the experimental models used, the animals were restored when tested at 100 days of age, but progressively became immunologically incapacitated at 200-300 days of age. From the more controlled experiments in which the restoring thymus graft was removed surgically, the following conclusions can be drawn. (a) A short exposure to a thymus graft can produce restoration of immune functions in neonatally thymectomized mice, but this restoration is not self-sustaining in the absence of the thymus and declines progressively with age. The decline usually starts at 200-300 days of age. (b) This was especially clear in experiments in which the same animal was tested twice in its lifetime for capacity to produce graft-versus-host reactions; these animals were competent at 100 days and became incompetent at 400 days of age. (c) The shortest period of thymic exposure studied was 10 days; if vascularization of the graft is taken into account, 2-3 days of thymic function are sufficient to produce restoration. (d) The immune decay observed in the thymectomized animals exposed temporarily to thymus was more profound than the physiological decay of immunity observed in control animals of similar age. (e) Of all the tests studied, the response of spleen cells to phytohemagglutinin was to be preserved the longest in animals exposed only temporarily to thymic function. The present results were interpreted in accordance with our previous findings indicating that a population of postthymic cells can be developed by temporary exposure of neonatally thymectomized animals to thymic function, but that this population is not self-sustaining in the absence of thymus and progressively decays by physiological attrition.


Changes in distribution of enzymes within the liver lobule during adaptive increases.


A study of the effect of prednisone and an antihistamine on patch test reactions.


Cofactor effects on enhancement in NADP reduction by chloroplasts.


Hypobaric chamber for oral flora study in simulated spacecraft environment.


Neurally mediated and direct effects of acetylstrophanthidin on canine skeletal muscle vascular resistance.


Revascularization of the periodontium after tooth grafting in monkeys.


Effect of acute volume loading on heart rate in the conscious dog.


The effects of some autonomic blocking agents on the heart rate of anesthetized and pithed rats.


A survey of selected drugs on behavioral performance in ethanol-treated rats.


The cardiovascular effects of terbutaline.


Mechanism of circulatory effects of chlorcyclizine.


Hemiallogeneic bone marrow transplantaton in a child with severe combined immunodeficiency disease.


The management of ulcerative colitis and granulomatous colitis.


Tyrosine aminotransferase induction regulation variant in tissue culture.


Analysis of the central receptors concerned in the cardiovascular response induced by intracerebroventricular aconitine.


Actions of 5-hydroxytryptamine and 5-hydroxytryptophan injected by various routes on the rectal temperature of the rabbit.


Relationships among Arrow-Dot IES scores and Wechsler IQS and MMPI scales for hospitalized, disturbed adolescents.


Comparative study of the effect of equine herpes 3 virus and herpes simplex virus on the chromosomes of rabbit kidney cells.


Phentolamine and beta-adrenergic receptors.


Dynamics of IgM, IgA and IgG antibody response in cases of human ophthalmic toxoplasmosis.


Pathogenicity of Bacterium anitratum for experimental animals.


Protection by glucocorticoids against allopurinol nephropathy.


Inhibitory effect of beta-adrenergic-blocking agent propranolol on histamine-stimulated gastric acid secretion in man.


Benign intracranial hypertension and ulcerative colitis.


Dental caries in trisomy 21.

Dental caries in trisomy 21.


Synthesis and some pharmacological activities of 4-alkylamino-2,3-dimethyl-l-phenyl-3-pyrazolin-5-one derivatives.


Purification of NAD-specific isocitrate dehydrogenase from porcine heart.


Method for microassay of microsomal heme oxygenase activity.


NAD + -dependent formation of 2-amino- 4 -hydroxy-6-carboxypteridine from 2-amino-4-hydroxy-6-formylpteridine by cell-free extracts of Escherichia coli.


Glucose-6-phosphate dehydrogenase adsorbed on collodion membranes.


A dental survey among 1,215 school children in the Kota Kinabalu district of Sabah, Malaysia.


Quantitative infectivity studies of avian reticuloendotheliosis virus (strain T) in certain hematophagous arthropods.


Effect of the convulsant methionine sulfoximine on the in vivo uptake and metabolism of D-methionine in rat brain.


Hemodynamic effects of beta adrenergic receptor stimulant and blockade. Hemodynamic effects of isoproterenol after propranolol..


Sleeping sickness survey in Musoma district, Tanzania. I. Investigation of the incidence of sleeping sickness in the human population.


Empyema thoracis in Nigerians.

Empyema thoracis in Nigerians.


Sleeping sickness survey in Musoma district, Tanzania. II. The role of Glossina in the transmission of sleeping sickness.


Sleeping sickness survey in Musoma district, Tanzania. 3. Survey of cattle for the evidence of T. rhodesiense infections.


Confidence intervals for percentage reductions.


Sleeping sickness survey in Musoma district, Tanzania. IV. Examination of wild mammals as a potential reservoir for T.rhodesiense.


Sleeping sickness survey in Musoma district, Tanzania. V. The endemicity of Rhodesian sleeping sickness in Ikoma-Serengeti area. Final discussion.


The ultrastructure of midgut epithelium in Aedes aegypti (L). (Insecta, Diptera) males.


Evaluation of the haematocrit centrifuge and other techniques for the field diagnosis of human trypanosomiasis and filariasis.


Non-specific esterases during development of Culicine mosquitoes.


The haematocrit centrifuge technique for the detection of low virulent strains of Trypanosomes of the Trypanosoma congolense sub-group.


Beta adrenergic blockade, 1972. Pharmacology and clinical uses.


A specific role of reduced adrenodoxin in adrenal mitochondrial steroid hydroxylases.


Production and preferential utilization of dihydroxyacetone phosphate for glyceride synthesis in the presence of glycerol 3-phosphate.


Catecholamine-depleting effect of black widow spider venom in iris nerve fibres.


Effect of pyridoxine defienciency on inducibility and circadian rhythms of some pyridoxine-dependent enzymes.


Temporal effect of m-fluorotyrosine on brain (prosencephalon and rhombencephalon) ammonia and glutamine during seizures.


Dopamine receptor blockade--a central action of chlorpromazine on striatal neurones.


Myocardial reactive hyperaemia responses in the dog after beta receptor block with propranolol.


Who's liable? Medicine and the law of agency.


Development of enzyme systems.

Development of enzyme systems.


Effects of adrenergic drugs on ciliary epithelium.


MMPI profile types and the self-report of psychiatric patients.


Immunological enhancement.

Immunological enhancement.


The effects of beta-adrenergic blockade on cerebral blood flow autoregulation: metabolic mechanism of cerebral autoregulation.


Infective endocarditis: past, present and future.


Effect of growth conditions on the ornithine decarboxylase activity of rat hepatoma cells.


The effect of oligomycin and factor C on respiration linked transhydrogenase in depleted submitochondrial particles.


The isolation and characterization of Rhodospirillum rubrum flavodoxin.


Photosystem I inhibition by polycations.


Bound TPN as the determinant of polymorphism in methemoglobin reductase.


Antagonism by bulbocapnine of adrenergic inhibition in parasympathetic ganglia in the urinary bladder.


Localization of photophosphorylation and proton transport activities in various regions of the chloroplast lamellae.


Salbutamol--an effective bronchodilator.


Proliferation of hemopoietic stem cells in culture of embryonal liver of mice.


Routine identification of drugs of abuse in human urine. II. Development and application of the XAD-2 resin column method.


Liquid-solid extraction of lyophilized biological material for forensic analysis. I. Application to urine samples for detection of drugs of abuse.


Oestrogen synthesis from (4- 14 C-1,2- 3 H)testosterone by placental microsomes from baboons.


Regulation of steroid biosynthesis in rabbit ovarian homogenates by pyridine nucleotides and citric acid cyclic intermediates.


Regulation of steroid synthesis in rabbit ovarian homogenates by luteinizing hormone, cyclic AMP and pyridine nucleotides.


Concerning the nature of the histamine-antagonistic effect of adrenaline in the pulmonary circulation.


Inhibited migration of peritoneal exudate cells altered by the local graft-versus-host reaction.


Prostaglandins in fertility control.

Prostaglandins in fertility control.


Studies of Patois group arboviruses in Mexico, Guatemala, Honduras, and British Honduras.


Passive hemagglutination inhibition technique for the identification of arthropod blood meals.


Agents encountered during arboviral ecological studies: Tampa Bay area, Florida, 1963 to 1970.


An investigation of the possible disadvantages of antihistamines in allergic asthma.


Allergy skin test. I. Antihistamine inhibition.


Oculocraniosomatic neuromuscular disease with "ragged-red" fibers.


Muscle transplantation into mice with muscular dystrophy.


Reduction of the selenotrisulfide derivative of glutathione to a persulfide analog by glutathione reductase.


The reaction mechanism of aldose reductase from Rhodotorula.


Molecular weight of the photoprotein aequorin.


Immunological surveys of arbovirus infections in South-East Asia, with special reference to dengue, chikungunya, and Kyasanur Forest disease. Serological surveys have been widely used in South-East Asia to determine the presence and activity of arboviruses. The haemagglutination-inhibition test has been most frequently employed but complement-fixation and neutralization tests have also been used in some investigations.Although virus isolations provide the most conclusive evidence, they can be carried out in a few specialized centres only, and serological surveys are very important for studying the distribution of arboviruses.The surveys have shown that group B arboviruses (principally all four types of dengue, Japanese encephalitis, and West Nile) are widely prevalent. Dengue and Japanese encephalitis viruses are more widespread than West Nile virus, which was not known previously to extend east of India although recent survyes have shown that its range extends to Burma. Japanese encephalitis is frequent in most of South-East Asia but in India is found mainly in eastern and south-eastern parts of the country. Kyasanur Forest disease (KFD) and Langat viruses are the only tick-borne group B arboviruses definitely known to occur in the region, the former in India, the latter in Malaysia. KFD virus has been isolated only from a small focus in Mysore, although human and animal sera containing neutralizing antibodies to this virus have been found sporadically in widely scattered areas. Among the group A arboviruses, chikungunya and Sindbis have been detected in serological surveys, but the former has not yet been found in Malaysia.


Daunorubicin metabolism by human hematological components.


Effects of autonomic blockade on the baroreflex in man at rest and during exercise.


Meeting the nation's health manpower needs.


Rates of transfer of organic protolytic solutes between an aqueous and an organic phase. I. A study of the transfer dependency of pH and the absolute rate of resolvation.


Empathy, warmth and genuineness in psychotherapy.


The effect of chronic adrenergic blockade on the inhibition by epinephrine of growth hormone and insulin release in sheep.


Substrate binding and reaction intermediates of glutamine synthetase (Escherichia coli W) as studied by isotope exchanges.


Action patterns of feedback modifiers on equilibrium exchanges and applications to glutamine synthetase (Escherichia coli W).


The myopathology of the Prune belly syndrome.


Effects of acetylcholine on the incorporation of ( 32 P) orthophosphate in vitro into the phospholipids of nerve-ending particles from guinea pig brain.


Comparative statistical investigations regarding incidence, etiology and topography of subacute bacterial endocarditis.


The course of infection of Japanese saurian malaria (Plasmodium sasai, Telford & Ball) in natural and experimental hosts.


Pulmonary disease with osinophilia.

Pulmonary disease with osinophilia.


Cardiac transplantation in mice. IV. Relationship between antithymocyte-globulin (ATG) dose, allograft survival and anti-ATG immunity.


Successful bone marrow grafts in experimental aplastic anemia using antilymphocytic serum for conditioning.


Torsion infarction in ectopic cryptorchidism: a rare entity occurring most commonly with spastic neuromuscular disease.


A study of the central action of flurothyl and methoxyflurane.


Characterization of a flavodoxin from the green alga Chlorella.


Marked enhancement of diplococcus pneumoniae competence for transformation by tryptic peptides of casein.


Mechanism of nitrate and nitrate reduction in Chlorella cells grown in the dark.


Molecular interactions of six aromatic competitive inhibitors with bovine liver glutamate dehydrogenase.


Activity of human placental sulfatase and 11  -hydroxysteroid dehydrogenase with respect to steroids of the pregn-4-ene C-21-yl sulfate series.


Haemodynamic effects of a new beta-adrenergic blocking agent: trasicor (CIBA  39089-Ba) in mitral stenosis.


In vitro induction of tyrosine aminotransferase in liver slices by hydrocortisone.


Alteration in graft vs host reactivity and in hematopoietic stem cells of spleen cell inocula from donor mice pretreated with pertussis antigen.


Aromatic amino acid hydroxylase inhibitors. 2. 3-Alkyl- -methyltyrosines.


Stereochemical aspects of antihistamine action. 4. Absolute configuration of carbinoxamine antipodes.


Microbiological and chemical modification of N-benzoyl-N,2,3,3-tetramethyl-exo-2-norbornanamine (N-benzoylmecamylamine).


4(5)-(2-Amino-1-hydroxyalkyl)imidazoles.


2-Aminoindan-2-carboxylic acids. Potential tyrosine hydroxylase inhibitors.


Absolute configuration of the optical isomers of salbutamol.


Complexities of teaching in the clinical laboratory.


An instructional simulation system offering practice in assessment of patient needs.


An example of community planning for nursing education.


The preparation of the nurse in the university setting.


Why they choose nursing.

Why they choose nursing.


A study of some possible mechanisms by which glucose inhibits drug metabolism in vivo and in vitro.


Adrenergic and cholinergic receptors of intestinal villi in dogs.


Structure and function of DNA-dependent RNA-polymerase.


Negative chronotropic response to phenylephrine of the canine S-A node.


Diplococcus pneumoniae infections in children with sickle cell anemia.


An enzymatic measurement of the riboflavin status in man.


Chemistry of the streptovaricins. VII. Revised structures for stretovarone and streptovaricin C.


Chemistry of the streptovaricins. VI. Oxidation products from streptovaricin C.


Age and the discriminative "power" of the MMPI with schizophrenic and nonschizophrenic patients.


Some personality characteristics related to response to subtle and obvious items on the MMPI.


Patient-therapist identification in relation to both patient and therapist variables and therapy outcome.


Effect of o-2-hydroxy-3-(tert.-butylamino) propoxybenzonitrile HCl (KO 1366) on beta adrenergic receptors in the cardiovascular system.


Local and neurally mediated effects of morphine on skeletal muscle vascular resistance.


A quantitative study of alpha adrenergic receptors in the spleen and aorta of the rabbit.


Microphallus: characteristics and choice of treatment from a study of 20 cases.


Failure of urogenital union with secondary amputation of the epididymal tail: a case report with complete review of the literature.


Evolution of recurrent lobular glomerulonephritis in a human kidney allotransplant. Combined light-, immunofluorescence-, and electron microscopic studies of serial biopsies.


Contrasting seroepidemiology of Australia antigen and arbovirus antibodies in New Guinea.


The antagonism of the local anaesthetic activity and of acute toxicity of propranolol and pronethalol by  -adrenergic blocking agents.


Reticulum cell sarcoma and hypercalcemia in an elderly woman.


Subcellular fractionation by differential and zonal centrifugation of aerobically grown glucose-de-repressed Saccharomyces carlsbergensis. 1. Homogenates were prepared from sphaeroplasts of aerobically grown glucose-de-repressed Saccharomyces carlsbergensis and the distributions of marker enzymes were investigated after differential centrifugation. Cytochrome c oxidase and cytochrome c were sedimented almost completely at 10(5)g-min, and this fraction also contained 37% of the catalase, 27% of the acid p-nitrophenyl phosphatase, 53 and 54% respectively of the NADH- and NADPH-cytochrome c oxidoreductases. 2. Zonal centrifugation indicated complex density distributions of the sedimentable portions of these enzymes and of adenosine triphosphatases and suggested the presence of two mitochondrial populations, as well as a bimodal distribution of peroxisomes and heterogeneity of the acid p-nitrophenyl phosphatase-containing particles. 3. Several different adenosine triphosphatases were distinguished in a post-mitochondrial supernatant that contained no mitochondrial fragments; these enzymes varied in their sensitivities to oligomycin and ouabain and their distributions were different from those of pyrophosphatase, adenosine phosphatase and adenosine pyrophosphatase. 4. The distribution of NADPH-cytochrome c oxidoreductase demonstrated that it cannot be used in S. carlsbergensis as a specific marker enzyme for the microsomal fraction. Glucose 6-phosphatase, inosine pyrophosphatase, cytochrome P-450 and five other enzymes frequently assigned to microsomal fractions of mammalian origin were not detected in yeast under these growth conditions.


Pharmacotherapy of cardiac arrhythmias in acute myocardial infarction.


Relationship between catecholamines and serotonin in sympathetic nerves of the rat pineal gland.


The effect of aging resolved chromatophores of Rhodospirillum rubrum on the capacity to reconstitute the energy-linked transhydrogenation.


Inhibition of erythroid cell growth in irradiated mice by allogeneic lymphoid cells: a quantitative method for graft-versus-host-reactivity of lymphoid cells.


Effect on male mice of a gonadotropic-like factor found in milk.


Interaction of thymus lymphocytes with histoincompatible cells. 3. Immunological characteristics of recirculating lymphocytes derived from activated thymus cells.


The role of the hypothalamo-neurohypophysial system in maintaining hydromineral balance in larval salamanders (Ambystoma tigrinum).


An assessment of the energy cost of gill ventilation in the plaice (Pleuronectes platessa L.).


Amino acids as olfactory stimuli in freshwater catfish, Ictalurus catus (Linn.).


Ultrastructure of the proximal convoluted tubule of a hibernator correlated with renal enzymology.


Unit responses from the nucleus angularis in the pigeon's medulla.


Avian intrapulmonary CO 2 -sensitive receptors: a comparative study.


Corticosterone and the circadian pigeon cropsac response to prolactin.


Immunochemical comparison of ovalbumins from nine different species.


The effect of acclimation temperature on amino acid transport in the goldfish intestine.


Relation of potassium to urate accumulation by kidney slices from desert spiny lizards (Sceloporus magister).


Daily fluctuations of DNA synthesis in the corneas of Rana pipiens.


Seasonal changes in hydrocortisone secretion rate of reindeer, Rangifer tarandus.


Some cardiovascular aspects of temperature regulation in the lizard Dipsosaurus dorsalis.


Iron kinetics in the frog (Rana montezumae).


Thermoelastic tension changes in the muscles of the abdominal stretch receptors of the crayfish.


Some comments upon acid-base balance in teleost fishes and its relationship to environmental temperature.


Alterations in sodium and potassium in red blood cells and plasma during the malaria infection (Plasmodium lophurae).


Acute effects of sea water on frogs (Rana pipiens).


Resonant panting in pigeons.

Resonant panting in pigeons.


Impaired thermoregulation in the thiouracil-treated neonate fowl.


Reversal effect on norepinephrine induced lipolysis in isolated perfused rat liver by a beta blocking agent H 56-28 (Alloprenalol).


Preclinical evaluation of the interrelationships between cancer chemotherapy and immunity.


Abnormal bactericidal, metabolic, and lysosomal functions of Chediak-Higashi Syndrome leukocytes. Phagocytic, antimicrobial, and metabolic functions were studied in leukocytes obtained from three patients with the Chediak-Higashi syndrome (CHS) and compared to normals, individuals, heterozygous for Chediak-Higashi syndrome, and two subjects with chronic granulomatous disease of childhood (CGD). Chediak-Higashi syndrome leukocytes showed normal ingestion of a variety of bacteria, Candida albicans, and polystyrene latex particles. Intracellular destruction was significantly impaired for Staphylococcus aureus, Group D streptococci, and a rough strain of Type II pneumococci over a 2 hr incubation. Killing of Serattia marcescens was consistently delayed at 1 hr whereas that of Escherichia coli and C. albicans appeared normal, unless the incubations were shortened to 20 min. Examination of the rates of killing indicated that the greatest defect occurred in the first 20 min of contact between Chediak-Higashi syndrome cells and bacteria. Separation of Chediak-Higashi syndrome granulocytes from monocytes revealed that the former were most defective in bactericidal activity. After phagocytosis, Chediak-Higashi syndrome granulocytes displayed a normal burst in oxygen consumption and oxidation of glucose-1-(14)C and glucose-6-(14)C and formate-(14)C. Oxidation of glucose-1-(14)C by non-phagocytizing Chediak-Higashi syndrome granulocytes and monocytes averaged 2-3 times normal, whereas glucose-6-(14)C and formate-(14)C oxidation were not significantly increased by resting cells. Iodination of intracellular protein by Chediak-Higashi syndrome leukocytes was significantly increased above normal in both the resting and phagocytizing state. Electron microscopic histochemistry revealed that almost all peroxidase activity was localized to the giant granules in Chediak-Higashi granulocytes, and after bacterial ingestion there was a failure of delivery of peroxidase to many phagosomes. Upon longer incubation more phagosomes acquired peroxidase activity, presumably through a fusion process, although many giant granules remained intact. The contrasting patterns and kinetics of the killing defects and the differing metabolic properties of Chediak-Higashi syndrome and chronic granulomatous disease leukocytes emphasize the pleiomorphic nature of inherited disorders of leukocyte function.


Improvement of patient care in a solo OB-GYN practice by using an R.N. physician's assistant.


Public perceptions of the physicians' assistant--a survey of the attitudes and opinions of rural Iowa and Minnesota residents.


New enzyme cycling method for determination of oxidized and reduced nicotinamide adenine dinucleotide.


Mold hyposensitization in rhinitis: a two-year study.


Assay of tyrosine hydroxylase by coupled decarboxylation of DOPA formed from 1- 14 C-L-tyrosine.


Lipid composition of sarcoplasmic reticulum of human skeletal muscle.


Effects of ethanol on lipid metabolism in adipose tissue.


A new method of isolating the cerebral cortex. Study of the normal and epileptic evoked activity.


Aging and brain enzymes.

Aging and brain enzymes.


Central nervous system stimulation and cardiac ischemic changes in monkeys.


Factors influencing the production of cardiomyopathies by methoxamine and metaraminol.


Mechanisms in the development of myocardial lesions in hemorrhagic shock.


Pharmacological studies on heart muscle lesions induced by isoproterenol.


A comparative study of the peroxidases from thyroid glands of pigeon (Columba livia domestica) and common myna (Acridotheres tristis).


Effect of thermal acclimation on multiple forms of the liver-soluble NADP + -linked isocitrate dehydrogenase in the family Salmonidae.


Study of tyrosine aminotransferase in developing salmon.


Paramedical help in Maine practice?

Paramedical help in Maine practice?


Brainstem encephalopathy following antirabic vaccination. A case report.


Effects of pure oxygen atmosphere in vivo on plasma lecithin-cholesterol acyltransferase reaction.


Red cell enzyme polymorphisms in rhesus monkeys and chimpanzees.


Tissue typing of rhesus monkeys: application in transplantation research.


The effect of adrenergic drugs on spontaneously active vascular smooth muscle studied by long-term intracellular recording of membrane-potential.


Immunochemical studies on malate dehydrogenase (decarboxylating) (NADP).


Thermal inactivation of alcohol dehydrogenases in the presence of NAD +  or NADP + .


CNS cellular level: membranes.

CNS cellular level: membranes.


Active centre equivalent weight of glutamate dehydrogenase from dry weight determinations and spectrophotometric titrations of abortive complexes.


Significance of catecholamine-induced ganglionic blockade and of reflex inhibition of adrenergic discharge at a peripheral locus as mechanisms producing reflex vasodilatation.


A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes.


Ethanol oxidation in rat-liver mitochondria.


Suppressor T cells.

Suppressor T cells.


Effect of C3 inactivator on bound C3 antigen.


Factors relating to selection of psychiatric residents.


DNA synthetic response of thymocytes to a variety of antigens.


Sharing experience through a visitors conference.


Standard 2. Organization is a process.

Standard 2. Organization is a process.


Immunologic reconstitution in severe combined immunodeficiency without bone-marrow chromosomal chimerism.


Erythropoiesis in mice with graft-versus-host reaction: effects of cells from various tissues on erythropoiesis and other measures of graft-versus-host reaction.


Individual differences in behavioral reactions of psychiatric patients to brief partial sensory deprivation.


Nurses' travel.

Nurses' travel.


Report of the Public Health Committee AMWA, the 1971 White House Conference on Aging: Dr. Geraldine Dickinson, Chairman.


The Joint Commission on Accreditation of Hospitals Standards for Nursing Services.


The white cat's tale.

The white cat's tale.


Good advice.

Good advice.


A nurse consultant in action.

A nurse consultant in action.


Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.


The dental health of South Australian country children.


L-Threonine acetaldehyde-lyase in a strain of Bacillus subtilis.


Action of actinomycin D on gastro-intestinal glucose uptake and on the glucose effect upon rat liver tyrosine transaminase activity.


Evaluation of a nursing consultant.

Evaluation of a nursing consultant.


Studies on peroxisomes. I. Intraparticulate localization of peroxisomal enzymes in rat liver.


6-Amnionicotinamide (6-AN) as a diabetogenic agent. In vitro and in vivo studies in the rat.


Supervisory development for nursing leaders.


Isoenzymes of NAD and NADP dependent dehydrogenases.


Quinones and nicotinamide nucleotides associated with electron transfer.


The binding of NAD +  and NADH to glyceraldehydephosphate dehydrogenase.


An overview of chronic recurring headache.


Yeast hemoglobin-reductase complex.

Yeast hemoglobin-reductase complex.


NADH-dependent cytochrome P-450 oxidase system in submicrosomal particles.


Glucagon in heart failure and in cardiogenic shock. Experience in 50 patients.


Simple fluorometric method for estimating practolol (1-(4-aminophenoxy)-3-isopropylaminopropan-2-0l) in blood and urine.


Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension. A comparative study of minoxidil and hydralazine.


Proceedings of clinical meetings of the Dermatological Society, India, West Bengal held at the skin department, Goenka Hospital, Calcutta University on April 17, 1971.


Purification and properties of a yeast nucleotide pyrophosphatase.


17 -Hydroxysteroid dehydrogenase of rat skin. Substrate specificity and inhibitors.


Pathway of L-sorbose metabolism in Aerobacter aerogenes.


The electron transport components of wild type and poky strains of Neurospora crassa.


Structural studies with the glycopeptides from porcine pancreatic ribonuclease.


Phenotypic mixing of vesicular stomatitis virus with fowl plague virus.


The influence of infection with Venezuelan equine encephalomyelitis virus on antibody response against sheep erythrocytes. I. Experiments on mice.


The influence of infection with Venezuelan equine encephalomyelitis virus on antibody response against sheep erythrocytes. II. Experiments on guinea pigs.


A simple quantitative microtest for determination of the complement fixing activity of foot-and-mouth disease virus.


SV40 neutralizing antibodies in the sera of man and experimental animals.


Adaptation to the laboratory mouse of rabies-like viruses isolated from wild rodents.


Multiplication of Langat virus in the tick Ixodes ricinus.


Pathogenicity of "wild-mouse" rabies-like strains for laboratory animals.


Enchanced plaque formation by Sindbis and vaccinia viruses under methyl-cellulose overlay in the absence of carbon dioxide.


Cultivation of Rickettsia tsutsugamushi in ixodid ticks.


Interaction between encephalomyocarditis (EMC) virus and polio-virus in cultured cells. Increase in the number of EMC virus-producing cells.


Chromosome aberrations in cytomegalovirus-infected human diploid cell culture.


Biophysical characteristics of Sindbis virion components.


Effect of some biological substances on the dog retractor penis in vitro.


Selective metabolic and cardiovascular beta receptor antagonism in the rat.


Adrenaline reversal after  -adrenergic blockade in conscious and anaesthetized animals.


Central and peripheral actions of the acetylcholine antagonist, ambutonium bromide.


The pharmacology of N,  -dimethyl-N- -chloroethylphenethylamine. Hci--effects on the autonomic nervous system.


Synthesis of alcohol and wax ester by a cell-free system in Mycobacterium tuberculosis.


Effect of prostaglandin E 1  on the induction of rat liver tyrosine aminotransferase.


Histochemical studies on proteins on the milkweed bug after juvenile hormone treatment.


Blockade of the antiadrenergic action of Bretylium by an aqueous extract of the leaves of Rhoeo spathacea.


Angiographic demonstration of total renal shutdown during apneic "diving" in the rabbit.


Amino acid contents of the brain and the muscle of young salmon (Salmo salar L.) at parr and smolt stages.


The postnatal induction of serine dehydratase in rat liver.


Organ distribution of exogenous  14 C-urea in elasmobranchs, with special regard to the nervous system.


Luminescence cross-reactions of Porichthys luciferin and theories on the origin of luciferin in some shallow-water fishes.


The influence of potassium and chloride ions on the membrane potential of single muscle fibers of the crayfish.


Intestinal absorption in ducklings (Anas platyrhynchos) maintained on fresh water and hypertonic saline.


Temperature selection by the bullfrog, Rana catesbeiana.


Cationic amino acid transport in chicken small intestine.


Renin secretion in a monotreme (Tachyglossus aculeatus).


Conjugation and excretion of administered estrogens in the rabbit, hen and cat.


Membrane resistance change induced by nitrate and other anions in long and short sarcomere muscle fibres of crayfish.


Evaluation of biological activity of chicken insulin in alloxan-diabetic rats.


The effect of sodium, calcium and magnesium on the amplitude of the action potential from giant neurons of Limnaea stagnalis.


Secretion of free glucose and related carbohydrates in the male accessory organs of rodents.


Red cell survival in the frog (Rana montezumae).


Ion and water balance in normal and mutant fluid imbalanced (ff) embryos of the axolotl (Ambystoma mexicanum).


Calcium action potentials in insect myocardial fibers.


Wavelength-dependent solar heating of harp seals (Pagophilus groenlandicus).


Ion transport in proximal and distal halves of turtle colon.


Estimation of extracellular space in rabbit detrusor muscle.


The metabolism of progesterone in the laying hen (Gallus domesticus).


Electrophysiological activity of tetrodotoxin on the resting membrane of the squid giant axon.


The ecological significance of certain new haematological findings in the mole and hedgehog.


II. Morphological and cultural characteristics of Culiseta inornata and Aedes vexans mosquito cell lines.


3. Antigenic relationships of mosquito cell lines as determined by immunodiffusion techniques.


IV. Production of human-mosquito somatic cell hybrids and their response to virus infection.


Ovarian-adrenal-liver interactions in the estrous cycle in the rat.


Studies on the nature of the privilege enjoyed by corneal allografts.


Influence of level and source of nitrogen intake on liver glutamine synthetase activity in the chick.


The ultrastructure of fishing tentacle muscle in the jellyfish Chrysaora quinquecirrha: a comparison of contracted and relaxed states.


Anaerobic energy metabolism in Moniliformis dubius (Acanthocephala).


Predictions of ethical risk taking by psychopathic and non-psychopathic criminals.


Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina. A catecholamine-sensitive adenylate cyclase system is present in homogenates of both calf and rat retinas. Dopamine is a more potent activator of the bovine enzyme than is norepinephrine or epinephrine. Cyclic AMP concentrations in intact bovine retina are increased by dopamine, as well as by other catecholamines, and by depolarizing agents. Studies with adrenergic blocking agents suggest that the stimulation of retinal adenylate cyclase by catecholamines cannot be clearly defined in terms of the characteristics of alpha or beta adrenergic receptors. Bovine retina also contains a protein kinase that is stimulated 20-fold by cyclic AMP. It is proposed that dopamine is the major activator of a retinal adenylate cyclase, and that this activation is related to its role as a neurotransmitter.


Studies on adrenal steroid hydroxylases. Reactivity of iron atoms in adrenal iron-sulfur protein (adrenodoxin) with iron-chelating agents.


Mood-modifying drugs prescribed in a Canadian city: hidden problems.


Bovine liver glutamate dehydrogenase. Equilibria and kinetics of imine formation by lysine-97 with pyridoxal 5'-phosphate.


Bovine liver glutamate dehydrogenase. Equilibria and kinetics of inactivation by pyridoxal.


A comparison of the size of the urinary bladder of two South American anurans of different habitat.


Hypertonic salt gland secretion in the glaucous-winged gull, Larus glaucescens, in response to stomach loading with dilute sodium chloride.


The effects of gonadectomy on osmoregulation in the migrating river lamprey: Lampetra fluviatilis L.


Physiological, demographic and pathological changes in wild Norway rat populations over an annual cycle.


Environmental influence of regulated body temperature in torpid hummingbirds.


Blood changes in torpid and non-torpid columbian ground squirrels, Spermophilus columbianus.


Anoxia and sodium loss associated with the death of brook trout at low pH.


Body compartmentalization and ion distribution in the teleost (Perca fluviatilis).


The composition of ovine mammary cells.

The composition of ovine mammary cells.


Glucose and fructose absorption in chronically immobilized rat.


Water metabolism of the bandicoot Isoodon macrourus Gould in the wild.


The impact of social aggregation on the respiratory physiology of Australian hopping mice.


The strengthening of cod connective tissue during starvation.


Co-ordination between the activity of the heart and the pectoral muscles during flight in the pigeon.


The cough or expulsion reflex in the Port Jackson shark, Heterodontus portusjacksoni.


Thermal acclimation and metabolic rates in the dusky salamander Desmognathus fuscus.


Seasonal variations in the pattern of lipids in the sexual segment, kidney and liver of the Indian house lizard, Hemidactylus flaviviridis Ruppell.


Extracellular spaces and composition of various tissues of perch.


The effect of thermal acclimation on heart rate and oxygen consumption of frogs during submergence.


Adrenergic and serotoninergic control of growth hormone secretion in adult male rats.


The effect of antiadrenergic drugs on ovulation in hens.


The effect of acute infection with Diplococcus pneumoniae on hepatic mitochondrial alpha-glycerophosphate dehydrogenase activity.


Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.


Regulation of diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Binding of inhibitory nucleotides.


Effect of prostaglandin E 1  administration on the liver glycogen synthetase and phosphorylase systems.


Nitromethane. A novel substrate for D-amino acid oxidase.


Plasma renin activity in hyper- and hypothyroidism: effect of adrenergic blocking agents.


A receptor kinetic model of a vascular neuroeffector.


Effect of propranolol upon the hemoglobin-oxygen dissociation curve.


Direct plaque-forming cell response to sheep red blood cells in rat spleen undergoing graft-versus-host reaction.


Effects of sympathetic and central nervous system alterations on the blood pressure responses to phentolamine.


Religious authoritarianism and psychopathology in college students.


In vivo formation of methionine sulfoximine phosphate, a protein-bound metabolite of methionine sulfoximine.


Aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12 . Subunit molecular weight and nicotinamide-adenine dinucleotide phosphate binding.


Isolation and structure determination of glucosylgalactosylhydroxylysine from sponge and sea anemone collagen.


Purification and properties of rat liver 6-phosphogluconate dehydrogenase. Activity at normal in vivo concentration of coenzyme.


Microsomal dehydrogenation of omega1-  and   omega2-hydroxy fatty acids.


Some physical-chemical properties of the rabbit's "sleep hemodialysate".


Blockade of biochemical and physiological responses of cardiac muscle to norepinephrine by N-tert.-butylmethoxamine (butoxamine).


Determination of sympathetic vasodilator responses during renal nerve stimulation.


Effects of nicotine and sympathomimetic amines on potassium intoxication.


Centrogenic cardiac arrhythmia induced by aconitine: a new "model" for screening of anti-arrhythmic drugs.


Adrenolytic property of NEM in the guinea pig atria in vitro.


Further studies on interfering peaks in gas chromatographic exclusion screening of direct chloroform extracts of blood.


Regional disappearance of catecholamines formed from  14 C-tyrosine in rat brain: effect of synthesis inhibitors and of chlorpromazine.


Soluble tyrosine aminotransferase deficiency: an unusual cause of corneal ulcers.


Interaction of thymus lymphocytes with histoincompatible cells. I. Quantitation of the proliferative response of thymus cells.


Cell-mediated immune response in vitro. I. A new in vitro system for the generation of cell-mediated cytotoxic activity.


The effects of anti-theta antiserum upon graft-versus-host activity of spleen and lymph node cells.


Suppression of graft versus host reactions in chickens by pretreatment of leucocytes with anti-light chain sera.


Response of urinary pregnanetriol to a single dose of human chorionic gonadotropin. A simple test to recognize testicular endocrine activity in prepubertal boys and adolescents.


Effect of beta adrenergic blockade on tremorine tremors in mice.


Leydig cell tumors of testis including cryptorchid testis.


Anti-inflammatory, analgesic and antipyretic activities of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284).


Can nasal bacterial flora be predicted from clinical findings?


Physician's assistant: why, who and how?


Long term therapy of ulcerative colitis with 6-mercaptopurine: a personal series.


Trans-synaptic regulation of growth and development of adrenergic neurones in a mouse sympathetic ganglion.


Physician's assistants--boon or bomb?

Physician's assistants--boon or bomb?


Altered norepinephrine metabolism, following experimental spinal cord injury. 2. Protection against traumatic spinal cord hemorrhagic necrosis by norepinephrine synthesis blockade with alpha methyl tyrosine.


Treatment of essential hypertension with combined vasodilation and beta-adrenergic blockade.


The effects of methoxamine on the pulmonary and systemic circulations in comparison to those of other sympathomimetic agents.


Preventive dentistry symposium.

Preventive dentistry symposium.


Endemic goitre in the Gilgit Agency, West Pakistan with an appendix on dermatoglyphics and taste-testing.


Effects of chemical and physical treatments on learning and memory.


Identification and treatment of acute psychotic states secondary to the usage of over-the-counter sleeping preparations.


Conversion of Hollander tests in man from positive to negative: beta-adrenergic blockade with propranolol hydrochloride.


Polyarteritis nodosa in a bovine carcase.


Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.


Dihydrofolate reductase. Purification and characterization of the enzyme from an amethopterin-resistant mutant of Escherichia coli.


The biosynthesis of 18-hydroxycorticosterone from exogenous corticosterone by teleost fish adrenocortical tissue in vitro.


Male infertility.

Male infertility.


Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action.


Clinical and bacteriological evaluation of intravenous doxycycline in severe hospital infections.


Evaluation of an aminotetraline, CP 14.368, as an antidepressant.


NADH diaphorase in erythrocytes. I. Partial purification of diaphorase.


An improved manual and semi-automatic assay for NADP-dependent isocitrate dehydrogenase activity, with a description of some kinetic properties of human liver and serum enzyme.


Tachyphylaxis of indirectly acting sympathomimetic amines. II. Recovery of tyramine tachyphylaxis and crossed tachyphylaxis between tyramine and other indirectly acting sympathomimetic amines in dogs.


Tachyphylaxis of indirectly acting sympathomimetic amines. I. Difference of pressor effect produced by repeated administration of ephedrine, methamphetamine and pheniprazine in dogs.


"Capillary permeability" in patients with collagen vascular diseases. "Capillary permeability" to serum albumin has been measured in patients with collagen vascular diseases by a method which compares the dilution of intravenously injected (131)I-human serum albumin and (51)Cr-R.B.C.s. The results indicate an increased capillary permeability comparable to that which occurs in patients with extensive inflammatory skin disease. We suggest that this increased capillary permeability may be the cause of the episodes of oedema which occur in patients with collagen vascular diseases such as disseminated lupus erythematosus, systemic sclerosis, dermatomyositis, polyarteritis nodosa, and rheumatoid arthritis. "Spontaneous periodic oedema" may be the presenting feature of collagen vascular disease and is due to increased capillary permeability.