The action of pharmacologically active substances on the flow and composition of cat hind limb lymph. 1. Lymph flow, blood flow and lymph protein concentrations have been measured in cat hind limb.2. When naturally occurring pharmacologically active compounds were infused close arterially to the hind limb it was found that histamine, bradykinin and acetylcholine were the most potent in increasing lymph flow.3. Dilatation of blood vessels per se is not sufficient to cause an increase in lymph flow since potent vasodilator agents such as isoprenaline and prostaglandins were not very active in increasing lymph flow.4. The effect on blood flow was rapid in onset and in return to basal flow, whereas the effect on lymph flow was delayed and prolonged. The duration of the effect on lymph flow was considerably greater with histamine and bradykinin than with acetylcholine.5. An increase in the protein concentration in the interstitial fluid is not a pre-requisite of an increase in lymph flow because (a) in some experiments an increase in lymph flow was not accompanied by an increase in lymph protein concentration after infusion of vasoactive substance and (b) the glucofuranoside, Glyvenol, was found to inhibit the increase in protein concentration but not the increase in lymph flow caused by infusion of histamine or bradykinin.6. In contrast the specific antihistamine, mepyramine, abolished the effect of histamine on lymph flow and lymph protein concentration and considerably reduced the effect on blood flow.7. An increase in venous pressure alone caused a small increase of lymph flow in about 50% of experiments, but when the venous pressure was increased at a time when vascular permeability was high, there was an increase in lymph flow in all experiments.8. When the venous pressure was low only histamine caused a significant increase in the lymph protein concentration, whereas bradykinin sometimes caused a small increase and acetylcholine mostly caused a decrease in the concentration of lymph protein.9. When the venous pressure was high, bradykinin and histamine and occasionally acetylcholine caused an increase in protein concentration in the lymph.10. Infusions of histamine, bradykinin or prostaglandin E(1) did not increase the leakage of intracellular enzymes into the lymph.


Cardio-selective beta-adrenoceptor blockade and the coronary circulation. After blockade of myocardial, but not coronary vascular beta-adrenoceptors by practolol, cardiac sympathetic stimulation or exogenously administered noradrenaline gave rise to coronary vasoconstriction, possibly due to stimulation of coronary alpha-adrenoceptors.


Reflex and other vascular changes in anaesthetized dogs after beta-adrenoceptor antagonism with alprenolol, bunolol and propranolol.


Blood levels of practolol following intravenous administration.


Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine. 1. Administration of two doses of amphetamine HCl (5 mg/kg intraperitoneally) 45 min apart raised body temperature of rats by an average of 3.4 degrees C and increased the turnover rate of brain 5-hydroxytryptamine (5-HT) by almost one-half.2. Both effects were blocked by exposure to 4 degrees C or by pretreatment with the beta-blocker Kö 592 (1-(2-methylphenoxy)-3-isopropylamine-2-propanol), but not by the administration of the ganglionic blocker chlorisondamine combined with atropine.3. Since it has previously been shown that hyperthermia per se increases the turnover rate of brain 5-HT, and that amphetamine does not directly affect the uptake and release of 5-HT in brain slices, it is concluded that the amphetamine-induced increase in 5-HT turnover may be secondary to the rise in temperature produced by the drug.


Studies on T-2636 antibiotics. IV. In vitro and in vivo antibacterial activity of T-2636 antibiotics.


Dental caries in children of immigrants in Liverpool.


Rifampicin in ophthalmology.

Rifampicin in ophthalmology.


Oxprenolol and practolol: new beta blockers.


Effect of propranolol on circulatory regulation.


The presence of beta-adrenergic receptors in the renal vascular bed.


Electron microscopy of vaccine and Breinl strains of Rickettsia prowazeki in louse gut cells.


Experimental approaches to the prophylaxis and treatment of ischaemic heart disease.


A technique for competitive inhibition of haemagglutination caused by arboviruses.


Precipitating antibodies in fractions of sera from patients with Botkin's disease.


Kemerovo virus from a migrating common redstart of Eurasia.


Interaction of plasma membranes with influenza virus. I. Isolation of plasma membranes from chick embryo cells.


Studies on RNA polymerase inhibitor formed in virus-infected cells. 3. Induction of inhibitor of cellular nucleic acid synthesis in vaccinia virus-infected cells.


Studies on restricted growth of herpesviruses in SV40-transformed cell lines.


Reproduction of herpes simplex virus in myxovirus-infected cell cultures.


Immunofluroescence study on the pathogenesis of fixed rabies virus respiratory infection in suckling mice.


Serological characterization of Eurasian Kemerovo group viruses. I. Cross complement fixation tests.


Serological characterization of Eurasian Kemerovo group viruses. II. Cross plaque neutralization tests.


Extraction of active fragment from Japanese encephalitis viral receptor of susceptible cells.


Persistence of virulent pseudorabies virus in herds of vaccinated and nonvaccinated pigs.


Morphological criteria of neurovirulence of viruses in viral vaccine production.


Cell wall deficient bacterial variants from man in experimental cardiopathy.


Treatment of angina pectoris.

Treatment of angina pectoris.


A system for lymphocytes in the mouse.

A system for lymphocytes in the mouse.


Studies on the excretion of [14C]histamine and its metabolites by the rabbit kidney. 1. After intravenous administration of [(14)C]histamine in rabbits, the urinary excretion of [(14)C]histamine and [(14)C]histamine metabolites was examined over a period of 4 hr.2. It was found that [(14)C]histamine was excreted in the unchanged form only in small amounts (6-7%), while 54-71% was eliminated in the form of its metabolites.3. Under normal conditions, the percentage excretion of metabolites, but not of histamine, showed a dose dependence. With the higher [(14)C]histamine dose, a significantly smaller proportion of the dose given was excreted as metabolites than with the lower dose. The proportion of unchanged [(14)C]histamine excreted remained constant.4. Pre-treatment with histamine infusions, or with mepyramine maleate, caused an increase in the excretion of [(14)C]histamine metabolites while the excretion of [(14)C]histamine remained unchanged.5. Pre-treatment with a diuretic, a combination of mersalyl and theophylline, did not influence the excretion of [(14)C]histamine nor of its metabolites.


The carrier effect and cellular cooperation in the induction of antibodies.


Cross-priming and cross-inhibition by antibody in the influenza virus--host antigen system.


Hapten competition and the nature of cell-cooperation in the antibody response.


Lymphocyte cooperation.

Lymphocyte cooperation.


Platelet adhesion in the rabbit abdominal aorta following the removal of the endothelium: a scanning and transmission electron microscopical study.


Studies on the structure and function of the mammalian testis. 3. In vitro steroidogenesis by the seminiferous tubules of rat testis.


On the dissociation of the sheep haemoglobin molecule at neutral pH. I. Osmotic pressure measurements.


On the dissociation of the sheep haemoglobin molecule at neutral pH. II. Sedimentation equilibrium measurements.


Palatopharyngeal fusion in a human fetus and its relation to cleft palate formation.


Immunophylogeny. A review of immune-like mechanisms of inverterbrate species.


Beta adrenergic blockade with practolol in hypertrophic obstructive cardiomyopathy.


Proximal tubule sodium reabsorption during water diuresis in patients with heart disease.


Comparison of effects of propranolol and practolol on exercise tolerance in angina pectoris.


The relation between circulating and tissue concentrations of salicylate in the mouse in vivo.


Adrenergic neuron blocking properties of (plus or minus)-propranolol and (plus)-propranolol.


The effect of acute adrenalectomy on the blood pressure responses to noradrenaline and to preganglionic nerve stimulation.


Some effects of experimentally-produced cigarette smoke on the growth, vitamin C metabolism and organ weights of guinea-pigs.


The interaction of ethanol and amphetamine metabolism.


The biliary metabolism of butylated hydroxytoluene (3,5-di-t-butyl-4-hydroxytoluene) and its derivatives in the rat.


Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens.


A note on the identification of sulphonamides by thin-layer chromatography.


Application of the delta-A method to the determination of morphine.


Photometric evaluation of dye diffusion in the skin.


Salicylates and gastric juice.

Salicylates and gastric juice.


Effects of desipramine, phentolamine and phenoxybenzamine on the release of noradrenaline from isolated tissues.


Non-antigenicity of a salicylamide derivative of aspirin.


A possible role for 5-hydroxytryptamine in drug-induced seizures.


Restoration of blood pressure and heart rate responses to tyramine by infusion of 5-hydroxytryptamine in reserpine-treated pithed rats.


Effects of cocaine and amphetamine on the metabolism of tryptophan and 5-hydroxytryptamine in mouse brain in vivo.


Effects of drugs on human foetal intestine: a preliminary investigation.


Influence of substituted tetrahydroisoquinolines on lipolysis, in vitro.


Transfer of morphine tolerance in rats by brain extracts.


Ultrastructural changes induced by pregnenolone nitrile in the rat liver.


Stereotyped behavior induced by (-)-ephedrine in rats.


Some pharmacological actions of alytesin and bombesin.


The potentiating effects of ethanol on response of aortic strips to stimulant drugs.


Stress-induced increases in catecholamines in the brain of the young chick.


Left ventricular performance at rest, during exercise and electrical pacing in conscious man before and after beta-blockade.


Glucose tolerance and immunoreactive insulin in patients with pheochromocytoma: the effect of alpha-receptor blocking agents.


Pteridines in flies of the genus Glossina (Diptera).


Host-parasite relationships of acarine parasites and their vertebrate hosts. II. Lesions produced by myobiid mites in the skin of their hosts.


Terrestrial snail a new host for trombiculid larvae.


Ingestion of erythrocytes by Entamoeba.

Ingestion of erythrocytes by Entamoeba.


Niridazole in the treatment of onchocerciasis.


Tick-host relationships. II. Factors affecting the circadian rhythm of "drop off" of engorged preimaginal stages of the tick Hyalomma excavatum (Koch, 1844) from the gerbil--Meriones tristrami.


The Yoruba Ibeji statue.

The Yoruba Ibeji statue.


Beta-adrenergic blocking drugs.

Beta-adrenergic blocking drugs.


The endodermal nerve net of scyphozoa.

The endodermal nerve net of scyphozoa.


Impairment of alpha receptor activity induced by cold storage in the isolated rabbit duodenum.


Formation and function of cytoplasmic annulate lamellae in the eggs of Pomatoceros triqueter L.


A reinvestigation of testicular-anterior pituitary relationships in the rat. I. Effects of castration and cryptochidism.


Synthetic gastrin as a dual adrenergic blocker.


Endocrine adjustments in a wild lemming population during the 1969 summer season.


Light and temperature effects on the oxygen consumption rhythms of the leafcutter bee, Megachile rotundata (Fabr.).


A comparative study of respiratory pigment concentrations in six species of turtles.


Temperature regulation in normothermic and hibernating eastern chipmunk, Tamias striatus.


Potassium, sodium, magnesium and calcium contents of Chinook salmon tissues during various stages of the life cycle.


Tubal pregnancy in a patient with an IUD.


The radiographic diagnosis of a traumatic diaphragmatic hernia.


Hydronephrosis.

Hydronephrosis.


Hypertension and duodenal ulcer associated with pneumocystis carinii pneumonitis and dysgamma-globulinemia.


The role of L-dopa in the functional rehabilitation of patients with Parkinson's disease.


Expansion of a local effort. The MECO project.


Refractory psoriasis--a new approach to the management.


The "art" of medicine.

The "art" of medicine.


The doctor as a target in malpractice.

The doctor as a target in malpractice.


Keeping of records.

Keeping of records.


"The appointment system--tool or terror".


Orthopaedic assistant now on the health scene.


Ethyl and grain alcohol counteract. Effects of methyl and wood alcohol.


Alprenolol treatment of angina pectoris.


The Fremont-Smith effect: an historical note.


Gastric lesions produced by cinchophen in the ferret.


Concomitant periodontal disease and dental caries in young adult males.


Effects of chlorcyclizine or phenobarbital on in vitro detoxication activity by larval wax moth gut homogenates.


Preoperative detection of hidden testes.


Beta adrenergic blockade in the circulatory regulation of hyperkinetic states.


Drug-induced pilomotion. An easily demonstrated alpha-effect of sympathomimetic drugs.


Evidence for the release of two atropine-resistant spasmogens from Auerbach's plexus. 1. Two atropine-resistant response-components of nervous origin have been detected in plexus-containing preparations of the longitudinal muscle from the guinea-pig ileum, by alternate field stimulation with equal numbers of pulses at 50 Hz (response A) and at 5 Hz (response B). With trains of ten or more pulses, response A is always larger than B; the ratio of A/B (1.2-21.3) is subject to animal variation.2. Both responses are abolished by tetrodotoxin and are absent from plexus-free preparations.3. Neither response is reduced by ganglion-block with (+)-tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion-paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.4. Neither response is due to a release of histamine, 5-hydroxytryptamine (5-HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin-antagonist SC-19220 (1-acetyl-2(8-chloro-10,11-dihydrodibenz [b,f] [1,4]oxazepine-10-carbonyl) hydrazine).5. The two response-components are affected differentially by a number of drugs.6. Histamine, 0.1 mug/ml., reduces response A to the level of B; this selective inhibition of the histamine-sensitive component in A is specifically antagonized by nicotine, 1-2.5 x 10(-5) g/ml.7. 5-HT, 0.1 mug/ml., and strychnine, 20-40 mug/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.8. Diphenhydramine, 10 mug/ml., produces equality of the two responses by depressing A and potentiating B.9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after alpha + beta adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea-pigs.10. In atropinized plexus-containing preparations of the longitudinal muscle from the guinea-pig descending colon, the responses elicited at 50 Hz and at 5 Hz are virtually equal and both appear to be of Type B since they are not inhibited by histamine, 5-HT or strychnine; diphenhydramine produces strong contractions.


Testicular tumor 18 years following orchiopexy: case report.


Arrhythmias, digitalis and respiratory failure.


Blocking of acetylcholine-induced fibrillation by use of norepinephrine into the AV node artery.


The cortical and medullary blood flows of the isolated dog's kidney.


Hypothalamic alpha- and beta-adrenergic systems regulate both thirst and hunger in the rat. Adrenergic and adrenolytic drugs were injected directly into the hypothalamus of the rat brain through permanently implanted cannulas and were found to have reliable effects on water consumption in water-satiated and water-deprived subjects. The beta-adrenergic agonist stimulated thirst, and the beta-adrenergic blocker suppressed thirst. Conversely, the alpha-adrenergic agonist suppressed thirst, and the alpha-adrenergic blocker enhanced thirst. These results demonstrate the existence of a hypothalamic beta-adrenergic "thirst" system which opposes a hypothalamic alpha-adrenergic "water-satiety" system. In view of our earlier results demonstrating the existence in the hypothalamus of an alpha-adrenergic "hunger" system which opposes a beta-adrenergic "food-satiety" system, we suggest that a reciprocal inhibitory relationship between these adrenergic hunger- and thirst-regulating systems provides a neurochemical explanation for the ability of organisms to maintain food and water consumption at a constant ratio. In the regulation of both hunger and thirst, the central cholinergic system mimics the hypothalamic beta-adrenergic system and opposes the hypothalamic alpha-adrenergic system.


The increase of dental caries in the adult female population of Hungary in the last 15 to 20 years.


Caries frequency and mottled enamel in Austrian regions with high natural F-content in the drinking water.


Dental caries after poliomyelitis.

Dental caries after poliomyelitis.


Wide variations of fluoride supply to infants and their effect.


The buccal absorption of some barbiturates.


The effects of pentobarbitone sodium on the carbon dioxide response and production, and oxygen consumption of the rabbit.


The phase diagram of cetomacrogol 1000-water-benzaldehyde in the presence of gallate antioxidants.


Adenyl cyclase activity of rabbit aorta.


Inhibition of acetylcholinesterase by dibenamine and dibenzyline.


The binding of indomethacin, salicylate and phenobarbitone to human whole blood in vitro.


A new approach to the study of serum concentrations of orally administered cephalexin.


Interaction and acute cross tolerance between ethanol and hexobarbitone in the rat.


Regional variations in the distribution of noradrenaline along the rat vas deferens.


An interaction between hydrocortisone and hemicholiniums in mice.


(3H)dopa in (3H)tyrosine with high specific activity: a serious complication in the study of catecholamine metabolism.


Uptake of [14C]histamine by tissues of the guinea pig.


Analgesic potency and stereochemistry of trimeperidine and its isomers and analogues.


A note on the chloroform-soluble alkaloids of Eagara macrophylla.


Lipid depletion of bacteria induced by biotin deficiency and its relation to resistance to antibacterial agents.


An improved field test for hallucinogens.


Aspirin polymorphism questioned.

Aspirin polymorphism questioned.


In vitro release of aspirin from various wax-coated formulations.


The aggregation of chlorhexidine digluconate in aqueous solution from optical rotatory dispersion measurements.


Tyrosine aminotransferase activity in a soluble extract of ergot fungus.


The effect of temperature and of cetrimide on the rate of loss of refractility of spores of Bacillus megaterium.


Advances in the treatment of hypertension.


Comparative study of duration of action and cardiovascular effects of bronchodilator aerosols.


A new test of the degree of adrenergic beta receptor blockade.


Depression of proximal tubular sodium reabsorption in the dog in response to renal beta adrenergic stimulation by isoproterenol. Water diuresis was produced in anesthetized hypophysectomized, cortisone-treated dogs by infusion of 2.5% dextrose. Alpha adrenergic blockade of the left kidney produced by infusion of phenoxybenzamine in the left renal artery was associated with a significantly (P < 0.05) greater rate of urine flow (V) and free water excretion (C(H2O)) in the left kidney than in the right despite similar glomerular filtration rates (GFR) (17 +/- 1.3 ml/min, left; 18 +/-0.9 ml/min, right). Sodium excretion (U(Na)V) was similar in the two kidneys (3 and 5 muEq/min). When beta adrenergic stimulation of the left kidney was superimposed on alpha blockade by the addition of isoproterenol to the left renal artery infusate, GFR remained unchanged and similar in the two kidneys, as V and C(H2O) increased significantly (P < 0.01) in the left kidney but not in the right. When isoproterenol was discontinued, V and C(H2O) returned towards control in the left kidney and remained unchanged in the right. The ratios of the left kidney to the right during control, isoproterenol, and postcontrol were 1.22, 1.65, and 1.35, respectively, for V and 1.36, 1.90, and 1.44, respectively, for C(H2O). Sodium excretion remained unchanged and similar in the two kidneys throughout the study. The results indicate that blockade of alpha adrenergic activity inhibits the increased proximal tubular sodium reabsorption which anesthesia induces in the dog. Beta adrenergic stimulation appears to decrease proximal tubular sodium reabsorption but does not prevent virtually complete reabsorption of the increased quantity of delivered sodium by the ascending limb of the loop of Henle and the distal tubule. These changes in sodium reabsorption presumably are not associated with changes in colloid osmotic pressure or hydrostatic pressure in the peritubular capillary inasmuch as cortical and non-cortical plasma flow, filtration fraction, and mean arterial pressure in the left kidney were unchanged. Thus, isoproterenol probably produced its effects through a direct action on the renal tubule, possibly through the mediation of the adenyl cyclase system.


L(S)- and D(R)-3-amino-1-phenylpyrrolidines. Stereoselective antagonists for histamine and acetylcholine receptors in vitro.


Experimental myocardial infarction. 8. Chronotropic augmentation of cardiac function in left ventricular failure of acute and healing stages in intact conscious dogs. The hemodynamic effects of tachycardia induced by atrial pacing were investigated in left ventricular failure of acute and healing experimental myocardial infarction in 20 intact, conscious dogs. Myocardial infarction was produced by gradual inflation of a balloon cuff device implanted around the left anterior descending coronary artery 10-15 days prior to the study. 1 hr after acute myocardial infarction, atrial pacing at a rate of 180 beats/min decreased left ventricular end-diastolic pressure from 19 to 8 mm Hg and left atrial pressure from 17 to 12 mm Hg, without change in cardiac output. In the healing phase of myocardial infarction 1 wk later, atrial pacing decreased left ventricular end-diastolic pressure from 17 to 9 mm Hg and increased the cardiac output by 37%. This was accompanied by evidence of peripheral vasodilation. In two dogs with healing anterior wall myocardial infarction, left ventricular failure was enhanced by partial occlusion of the circumflex coronary artery. Both the dogs developed pulmonary edema. Pacing improved left ventricular performance and relieved pulmonary edema in both animals. In six animals propranolol was given after acute infarction, and left ventricular function deteriorated further. However the pacing-induced augmentation of cardiac function was unaltered and, hence, is not mediated by sympathetics.The results show that the spontaneous heart rate in left ventricular failure of experimental canine myocardial infarction may be less than optimal and that maximal cardiac function may be achieved at higher heart rates.


The treatment of functional heart disorders with beta-adrenergic blocking agents.


The dental needs of Birkirkara primary school children.


Neuroid conduction and the evolution of conducting tissues.


Comparison of haemodynamic effects of alpha-sympathomimetic drugs.


Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis.


Effect of propranolol and [4-(2-isopropylamino-1-hydroxyethyl) methanesulphonanilide hydrochloride] (MJ-1999) on pulmonary circulation.


The application of various correlations in dental measurements and oral hygiene.


The effects of amino acids and some related substances on isolated preparations of the sea anemone Actinia equina.


Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide.


Fate of Bacillus subtilis transforming deoxyribonucleic acid incorporated into transformable Diplococcus pneumoniae.


Simplified method for measuring compliance of superficial veins.


Catecholamines and local rebound in left ventricular contractile force after release of coronary artery occlusion.


Relationship of betel chewing and dental caries.


Conference on school health...a summary.


Current concepts of the basic mechanisms of action of autonomic drugs with special reference to the eye.


The heterogeneity and molecular transformations of glucose-6-phosphate dehydrogenase of the rat.


Glycolytic enzyme activities in bovine hard dental tissue at different ages.


Is group practice the answer?

Is group practice the answer?


Diphtheria in Chicago. 1960-1970.

Diphtheria in Chicago. 1960-1970.


The view box. Neuroblastoma.

The view box. Neuroblastoma.


Toxic megacolon.

Toxic megacolon.


hMO or FMC? Drastic changes ahead in medical care.


"Health care delivery changes in the 70s". Today's health care delivery is sick.


"Health care delivery changes in the 70s". HEW's Rx:HMO.


"Health care delivery changes in the 70s". American Hospital Association views.


"Health care delivery changes in the 70s". Health Insurance Council's formula.


"Health care delivery changes in the 70s". Nat'l Blue Cross views alternatives.


The hypochondriacal patient in the physician's office.


Studies on hypotensive action of properciazine.


Differentiation of ganglionic cells in Hydra.


Estimates of probability of transmitter release at the mammalian neuromuscular junction. 1. Intracellular records of end-plate potentials (e.p.p.s) were obtained from curarized neuromuscular junctions in the rat diaphragm.2. Statistical estimates of the quantal release probability (p) were made at individual junctions from measurements of the means and variances of e.p.p. amplitudes at two different levels of Ca concentration. It was assumed that the release process was binomial and that the number of quanta available for release (n) was independent of external Ca.3. These estimates of p were compared with those obtained by measuring depression of e.p.p. amplitudes after single conditioning shocks and assuming that the depression was due to depletion of n. The statistical estimates were consistently smaller.4. This disparity, plus the additional observation that depression was not linearly related to the number of quanta released by one or more conditioning shocks, suggested that depression was not due entirely to depletion and that the depletion assumption led to an over-estimate of p.5. A third method of estimating p from measurements of the decline of e.p.p. amplitudes during rapid stimulation also appeared to result in an over-estimate.


The physician, his assistants, and Pennsylvania law.


The growth of radiology as a major discipline in American medicine.


New viruses associated with the hemorrhagic fever syndrome.


Effect of combined Mycoplasma pneumoniae and pneumococcal infections in hamsters.


Light-dependent consumption of oxygen by Vicia faba chloroplasts.


Major pathways of glycine and serine catabolism in rat liver.


An ADP-glucsoe pyrophosphorylase with lower apparent affinities for substract and effector molecules in an Escherichia coli B mutant deficient in glycogen synthesis.


Circular dichroism studies of the complex between ferredoxin and ferredoxin-NADP reductase.


Inhibition of nucleoside incorporation into HeLa cells by streptovaricin.


Psychological and neurological comparisons of psychomotor and non-psychomotor epileptic patients.


The use of irradiated immune lymphoid cells for immunotherapy of primary tumors in rats.


Tuna, starfish and kelp.

Tuna, starfish and kelp.


Metabolism of bone cells in a perfusion system. I. The localization of alkaline phosphatase.


The biochemical and antimicrobial activities of phagocytizing cells.


Serious arterial complications following removal of failed renal allografts.


North Carolina physicians' interest in physicians' assistants.


Comparative studies on the sense organs on the antennae and maxillary palps of selected male culicine mosquitoes.


The absence of electrically demonstrable polarizing factors in Hydra.


Clinical and pathologic characteristics of graft-versus-host disease produced in cyclophosphamide-treated adult mice.


Locums and assistants.

Locums and assistants.


Catecholamines and thyroid activity.

Catecholamines and thyroid activity.


Comments on the early development of gastroenterology in the United States of America.


Frontal sinus surgery.

Frontal sinus surgery.


A new spectral intermediate associated with cytochrome P-450 function in liver microsomes.


The hyperglycaemic activity of some catecholamines and the effect of alph- and beta-adrenergic blocking compounds in the mouse.


Incomplete membrane-bound photosynthetic electron transfer pathway in agranal chloroplasts.


Strophocheilus oblongus heart mitochondria: respiration and oxidative phosphorylation.


Differential X-ray sensitivity of hydras in relation to age.


Histoenzymological properties of Askanazy-Hürthle cells of the thyroid gland and neoplasms of these cells.


Boophilus microplus: antihistaminic and tranquillizing drugs and cattle resistance.


Did the pundit do his homework?

Did the pundit do his homework?


Evidence for the presence of 17 beta-hydroxysteroid oxido-reductase and 19-hydroxylase systems in domestic duck (Anas platyrhynchos) adrenal mitochondria.


Thelytochous partenogensis in Cereus pedunculatus (Actiniaria).


The treatment of chronic hypertension.

The treatment of chronic hypertension.


Diagnostic and therapeutic aspects of stable angina pectoris.


Isotope derivative method for determination of microquantities of inorganic pyrophosphate in biological material.


The effects of 2-ethylcitrate and tricarballylate on citrate transport in rat liver mitochondria and fatty acid synthesis in rat white adipose tissue.


Allotypic suppression in rabbits. Operational characterization of the target cells.


Fluoridation studies and dental caries. A review.


Autosensitization in vitro.

Autosensitization in vitro. Autosensitization of rat or mouse lymphoid cells against syngeneic fibroblast antigens was induced in cell culture. Rat lymphoid cells autosensitized by this method were able to produce immunospecific lysis of syngeneic target fibroblasts in vitro or GvH reactions in newborn rats. Autosensitized mouse spleen cells mediated similar GvH reactions when injected into newborn mice. The nature of the system used to induce immunity in vitro appears to argue against the possibility that lymphocytes capable of reacting against self-antigens could arise by mutation in cell culture. Hence, it is likely that cells potentially reactive against self-antigens preexisted in the lymphoid cell donors. The ability of autosensitized cells to mediate immune reactions in vivo suggests that the immunogenic self-antigens present on sensitizing fibroblasts also were accessible in the intact animals. Loss of natural self-tolerance in vitro, therefore, can be explained most simply by the existence of lymphocytes which are reversibly tolerant to self. Hence, ontogenic elimination of potentially self-reactive cells may not be the only basis for natural tolerance. Regulatory mechanisms, such as antigen excess, may have to function in vivo to prevent differentiation of self-tolerant lymphocytes. These regulatory mechanisms appear to be annulled in the cell-culture system. The present system thus may offer a new approach to studies of tolerance and regulation of cellular immunity.


The factor of immunization in the rat. The effect of allogeneic immunization on graft-versus-host activity. Using a popliteal lymph node weight assay the graft-versus-host activity of lymphocytes from donors immunized with allogeneic tissue has been assayed by comparison with that of lymphocytes from nonimmune donors. When the donors were immunized against weak histocompatibility antigens (non-AgB) the specific GVH activity of its lymphocytes was increased. This increase was greater if spleen cells rather than thoracic duct lymphocytes were the source of the donor cells used for assay. The increase in GVH activity was also greater if the standard immunization procedure of two successive skin allografts was followed by three boosting injections of allogeneic lymphoid cells. When donors were immunized against strong histocompatibility antigens the specific GVH activity of the donors' lymphocytes was slightly increased, was unchanged, or was actually decreased depending on the experimental situation. In donors rendered incapable of a humoral alloantibody response by whole body X-irradiation, immunization across a strong barrier was followed by little or no increase in the specific GVH activity of TDL. In the rat, as in other species, the increase in GVH activity after immunization is inversely proportional to the strength of the antigenic barrier involved.


Serologic characteristics of glucokinases from Entamoeba histolytica and related species.


Present status of resistance and susceptibility of four species of West Malaysian culicine mosquito larvae to insecticides.


Soyuz-9 flight, a manned biomedical mission.


Hepatitis associated antigen and periarteritis nodosa (PAN).


Human placental 17 beta-estradiol dehydrogenase. VI. Substrate specificity of the diphosphopyridine nucleotide (triphosphopyridine nucleotide)-linked enzyme.


The effect of temperature and some mediator antagonists on anaphylactic shock in mice.


Responses of coronary vessels to adrenergic stimuli. Coronary responses to adrenergic stimuli were determined in the intact beating heart before and after administration of practolol, 4-(2-hydroxy-3-isopropylaminoproproxy) acetanilide, which in low doses blocks myocardial but not vascular beta receptors. The left circumflex coronary artery of dogs was perfused with arterial blood at constant flow, and coronary perfusion pressure was measured. Before practolol, intracoronary injections of isoproterenol and norepinephrine and electrical stimulation of left cardiac sympathetic nerves caused reductions in perfusion pressure or vasodilatation associated with increases in left ventricular dp/dt, heart rate, and systolic pressure. After practolol, the coronary vasodilator response to isoproterenol was reduced by about 30% and occurred without significant changes in dp/dt, heart rate, and pressures. The addition of propranolol blocked completely the coronary responses to isoproterenol. Vascular responses to isoproterenol in the paw were not altered by practolol. Practolol antagonized the increases in dp/dt, heart rate, and systolic pressure and reversed coronary responses to norepinephrine and nerve stimulation from dilatation to constriction. The constriction, in turn, was reduced or reversed by phentolamine, an alpha receptor antagonist. Propranolol did not augment the constriction seen in response to norepinephrine and nerve stimulation after practolol. These results indicate that the coronary vasodilator action of norepinephrine and sympathetic nerve stimulation is indirect and caused by stimulation of myocardial beta receptors. The direct effect of these two stimuli on coronary vessels is minimal and is mediated through stimulation of alpha (vasoconstrictor) receptors. In contrast, the coronary vasodilator response to isoproterenol is both direct and indirect, resulting from stimulation of vascular and myocardial beta receptors; the direct vascular effect predominated in this study.


Ontogenesis of cell-mediated immunity in murine thymocytes and spleen cells and its acceleration by thymosin, a thymic hormone.


Regional bioenergetic events in the experimental glioblastoma. Aquantitative histochemical study.


Management of thrombotic diseases.

Management of thrombotic diseases.


An appraisal of preperitoneal repair of inguinal hernia.


Prolongation of rat skin allograft survival with isonicotinic acid hydrazide and methapyrilene hydrochloride.


Is methodone enough? The use of ancillary treatment during methadone maintenance.


The effect of temperature on the variability of ECHO 9 (Hill) virus: description of mutants.


Join the microsomal bandwagon.

Join the microsomal bandwagon.


Purification and properties of a nicotinamide adenine dinucleotide phosphate-requiring glyceraldehyde 3-phosphate dehydrogenase from spinach leaves.


Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.


In vivo formation and catabolism of (14C) histamine in mouse brain.


Physician's assistants.

Physician's assistants.


The clinical anticariogenic effectiveness of supplementary fluoride-vitamin preparations. (Results at the end of five and a half years).


The immunological consequences of organ homotransplantation in man.


The nurse as physician's assistant. Con...


The nurse as physician's assistant.

The nurse as physician's assistant.


Associations between drugs administered during pregnancy and congenital abnormalities of the fetus. In a retrospective study to compare the drug consumption during pregnancy of mothers of infants with congenital abnormalities and of those without, over 97% of 1,369 mothers took prescribed drugs and 65% self-administered drugs. Significantly more mothers of infants with congenital abnormalities took aspirin, antacids, dextroamphetamine, phenobarbitone, sodium amytal, other barbiturates, cough medicines, iron, sulphonamides, and nicotinamide than mothers in the control group. However, most mothers taking analgesics, antacids, appetite suppressants, barbiturates, cough medicines, iron, sulphonamides, and vitamins produced normal infants. Any teratogenic effect of these drugs is therefore one of low potency. On the other hand, deficiencies such as those of ascorbic acid and folic acid may have a teratogenic effect. There is need for caution in presuming teratogenic effects on the basis of the associations shown here. During pregnancy, however, it would appear wise to avoid the administration of any drug which carries a suspicion of teratogenicity unless that drug is specifically indicated, and self-medication with common household remedies such as aspirin and antacids should be avoided. These recommendations would also apply to any woman of childbearing age in whom conception is likely.


Practolol in angina.

Practolol in angina.


Safety of combined antidepressant drugs.


The nurse as physician's assistant. Pro...


"Health care delivery changes in the 70s". Hennepin County's program.


"Health care delivery changes in the 70s". FMO: "a better cure".


Psychotropic drugs and amygdaloid after-discharge. An experimental study on the cat.


Structural differentiation of stacked and unstacked chloroplast membranes. Freeze-etch electron microscopy of wild-type and mutant strains of Chlamydomonas. Wild-type chloroplast membranes from Chlamydomonas reinhardi exhibit four faces in freeze-etchreplicas: the complementary Bs and Cs faces are found where the membranes are stacked together; the complementary Bu and Cu faces are found in unstacked membranes. The Bs face carries a dense population of regularly spaced particles containing the large, 160 +/- 10 A particles that appear to be unique to chloroplast membranes. Under certain growth conditions, membrane stacking does not occur in the ac-5 strain. When isolated, these membranes remain unstacked, exhibit only Bu and Cu faces, and retain the ability to carry out normal photosynthesis. Membrane stacking is also absent in the ac-31 strain, and, when isolated in a low-salt medium, these membranes remain unstacked and exhibit only Bu and Cu faces. When isolated in a high-salt medium, however, they stack normally, and Bs and Cs faces are produced by this in vitro stacking process. We conclude that certain particle distributions in the chloroplast membrane are created as a consequence of the stacking process, and that the ability of membranes to stack can be modified both by gene mutation and by the ionic environment in which the membranes are found.


Graft-versus-host reaction modified by in vitro preincubation of marrow with subcellular antigen.


The isolated perfused heart preparation: two suggested improvements.


Animal models for bone-marrow transplantation.


The response to cardioactive drugs of hearts maintained in organ culture.


Analysis of the adrenergic receptors in the urinary tract of dog.


Clinical and laboratory evaluation of an expired anesthetic gas monitor (Narko-Test).


Studies on the mechanism of fatty acid synthesis. XXV. On the mechanism of beta-ketoacylacyl carrier protein reductase from Escherichia coli.


The chemistry of dryopteris acylphloroglucinols.


Colimetric determination of amphetamine salts in dosage forms.


The determination of sodium aminosalicylate in cachets of sodium aminosalicylate and isoniazid by ultraviolet absorption.


The effect of sodium salicylate on the binding of long-chain fatty acids to plasma proteins.


The transfer and penetration of fatty alcohols and fatty acids in relation to their self-bodying action in emulsions.


An in vitro model for drug absorption studies.


Medicament release from fatty suppository bases.


Pharmacological actions of phosphocholine 2,6-xylyl ether bromide (phospho-TM10; PTM10).


The influence of angiotensin on the uptake of noradrenaline by the isolated heart of the rabbit.


The inhibitory effect of sulphonylurea derivatives on liver glycogenolysis increased by catecholamines.


Acid gastric secretory responses to histamine, crude porcine gastrin and pentagastrin in rats.


Investigation of the mechanism of gelatin-induced in vitro red cell aggregation.


Free fatty acid inhibition of alpha-glycerophosphate dehydrogenase activity in rat brain.


Utilization of acetylsalicylic acid as sole carbon source and the induction of its enzymatic hydrolysis by an isolated strain of Acinetobacter lwoffii.


Sympathomimetic action of tetanus toxin.


Pharmacological observations on phyllomedusin.


Toxicity of ethanol barbiturate mixtures.


A simple method for chronic measurement of the electrocardiogram and blood pressure in the conscious rat.


The isolation and identification of quininone from Cinchona ledgeriana.


The isolation and identification of jollyanine from Tabernamontana cumminsii.


Polyarteritis and intrarenal renal artery aneurysms.


Evaluation of Levodopa for Parkinsonism. Levodopa (Dopar, Larodopa).


Active molecular unit and NADP content of human glucose 6-phosphate dehydrogenase.


Changes in the time course of transmitter action produced by procaine. 1. In addition to reducing the sensitivity of the end-plate to transmitter, procaine produced changes in the time course of the end-plate potential. The time to peak potential was reduced by procaine, whether recording from fibres paralysed by tubocurarine or from fibres paralysed by high magnesium concentration. The rate of decay of potential was also markedly reduced. Similar observations were made recording spontaneous miniature end-plate potentials.2. Procaine did not produce any marked change in the electrical constants of muscle fibres.3. In the presence of procaine the accumulation of charge at the end-plate was prolonged; the rate of decay of charge was reduced. It is suggested that the prolonged end-plate potentials arise from a prolongation of the end-plate current.


Beta-adrenoceptor antagonist activity of 3-methoxyisoprenaline. 1. The beta-adrenoceptor antagonist activity of 3-methoxyisoprenaline, the O-methylated metabolite of isoprenaline, was studied on isolated driven atrial strip and tracheal chain preparations of the guinea-pig and on the hind limb blood flow of the dog.2. On both the atrial strip and tracheal chain preparations the blockade of responses to isoprenaline fulfilled the criteria for simple competitive inhibition.3. 3-Methoxyisoprenaline decreased the vasodilator response to isoprenaline in the dog hind limb, but did not affect the response to noradrenaline.4. 3-Methoxyisoprenaline had about 1/3,700 of the potency of propranolol as a beta-adrenoceptor antagonist on the tracheal chain preparation, 1/1,000 on the atrial strip preparation and less than 1/400 on the hind limb blood flow.5. The antagonist activity of 3-methoxyisoprenaline showed a slight specificity for cardiac beta-adrenoceptors, being 4.3 times more active on guinea-pig atria than on trachea.6. Although 3-methoxyisoprenaline antagonized the actions of isoprenaline in the three preparations, its activity was extremely weak. It is unlikely that the formation of 3-methoxyisoprenaline from isoprenaline, administered therapeutically, could lead to beta-adrenoceptor blockade.


Effect of beta-adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea-pig air overflow preparation. Appendix describing a new modification of the air overflow method. 1. Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea-pig.2. After adrenalectomy, propranolol was still active, though less so than before.3. In the pithed guinea-pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the beta-adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967).4. Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea-pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.


Cardiovascular effects of toxins isolated from the cnidarian Chironex fleckeri Southcott. 1. Two unstable high molecular weight toxins have been isolated from tentacles of Chironex fleckeri by exclusion chromatography. Both are cardiotoxic; the lower molecular weight fraction is also a potent haemolysin.2. Both toxins reduce the rate, amplitude of contraction and coronary flow in the isolated, perfused guinea-pig heart. Relative to the mouse lethal dose the haemolytic fraction is less potent in this preparation than the purely cardiotoxic fraction.3. Both toxins cause a rise in arterial pressure in anaesthetized rats and rabbits by a direct action on the vascular musculature. This is followed by hypotension, bradycardia and cardiac irregularity. An increase in respiratory rate is followed by apnoea of variable duration, which is associated with a rise in arterial pressure. Animals frequently show arterial pressure oscillations with periods of apnoea interspersed with hyperpnoea.4. The carotid occlusion reflex is depressed during hypotensive periods after both toxins, although (-)-noradrenaline can still elicit a marked pressor response. Bilateral cervical vagotomy has but little effect on the response to either toxin, save to prevent hyperpnoea, but radical denervation of sinoaortic afferents reduces the arterial pressure fall after the initial hypertensive response, suggesting that this fall is due to a combination of baroreceptor stimulation and a fall in cardiac output. Blood pressure oscillations are still seen, possibly due to central stimulation by hypercapnia.5. Interference with the efferent arm of the vasomotor reflex arc with hexamethonium, bretylium or phenoxybenzamine either abolishes or markedly reduces the blood pressure oscillations without affecting the initial hypertensive response.6. The cardiovascular effects of the two toxins are thought to be due to direct vasoconstriction, cardiotoxicity, baroreceptor stimulation and possibly depression of the vasomotor centre. The resultant disordering of the feed-back system regulating vasomotor tone leads to the characteristic arterial pressure oscillations.


On the neuromuscular paralysis produced by procaine. 1. The effects of procaine on neuromuscular transmission in the rat phrenic nerve diaphragm preparation have been examined using intracellular recording techniques.2. The paralysis produced by procaine resembled that produced by tubocurarine and it is concluded that this effect of procaine results from a change in post-junctional sensitivity to transmitter; at low rates of stimulation procaine did not depress the transmitter release.3. During high frequency stimulation of the phrenic nerve a distinct form of prejunctional failure was observed. It is suggested that this depression results from a combination of local anaesthesia and anoxia and that it would explain reports of a reduction in the amount of transmitter released when assayed in a conventional manner.


Trial of practolol (Eraldin) in treatment of supraventricular cardiac arrhythmias in the elderly.


Cutaneous reactions to intradermal prostaglandins. 1. The effects of intradermally injected prostaglandins (PGs) E(1), E(2), F(1alpha) and F(2alpha) have been examined in the rat and in man.2. PGE(1) and PGE(2) caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, bradykinin, and 5-hydroxytryptamine), but PGF(1alpha) and PGF(2alpha) were only slightly active even at a dose of 1 mug.3. Prior administration of mepyramine and methysergide, or depletion of skin mast cell amines with compound 48/80, indicated that PGE(2) exerted its permeability effect in the rat by a release of mast cell amines.4. Nanogramme doses of PGE(1) and PGE(2) or microgramme doses of PGF(1alpha) and PGF(2alpha) injected intradermally into the human forearm induced weal and flare responses.5. It is concluded that prostaglandins E(1) and E(2) can act as intermediates in the production of hyperaemia and oedema resulting from cell damage in the rat and man.


Evaluation of the marine physician assistant program.


Evidence for the release of two non-cholinergic spasmogens from the plexus-containing longitudinal muscle of the guinea-pig ileum.


Stress and its influence on gestation.

Stress and its influence on gestation.


The physician's assistant.

The physician's assistant.


Pseudomonas osteomyelitis following puncture wounds of the foot.


Integrated response to exercise in patients with hypertrophic obstructive cardiomyopathy and effect of beta-adrenergic blockade on oxygen transport.


Health care delivery.

Health care delivery.


ppearance of a protein "agglutinin" on the spheroplast membrane of pneumococci during induction of competence. Competent pneumococci and their spheroplasts agglutinate in dilute acid. Agglutination is caused by a trypsin-sensitive agglutinin which is not identical to the competence factor and the appearance of which requires protein synthesis.


Physician productivity and medical care.


Characterization of the reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase of Aspergillus nidulans. The reduced nicotinamide adenine dinucleotide phosphate (NADPH)-nitrate oxidoreductase (EC 1.6.6.2) from Aspergillus nidulans was purified over 200-fold by use of salt fractionation, gel filtration, and ion-exchange chromatography. The purified enzyme was specific for NADPH and catalyzed reduction of nitrate, cytochrome c from isolated mitochondria of Aspergillus, and mammalian cytochrome c. An S(0.725) (20, w) of 7.8 was derived with sucrose density gradient centrifugation, and a Stokes radius of 6.4 nm was derived by gel filtration on Sephadex G-200. From these values, a molecular weight of 197,000 was computed, assuming v = 0.725 cm(3)/g. The spectral properties of the purified enzyme suggested a flavine component was present but revealed no pattern indicative of a hemoprotein. A cytochrome c, similar to the cytochrome c from isolated mitochondria, was found unassociated with the nitrate reductase after ion-exchange chromatography. No NADPH-nitrate reductase activity was detected in isolated mitochondria. Spectrally discernable reduction of the flavine component of the enzyme at 450 nm was noted after reaction with NADPH. This reduction was inhibited by p-chloromercuribenzoate but not by KCN. The addition of nitrate to NADPH reduced enzyme caused a reoxidation of the flavine component via a reaction which was inhibited by KCN but not by p-chloromercuribenzoate. The half-life of the purified enzyme at 37 C was 20 min for NADPH-nitrate reductase and 35 min for NADPH-cytochrome c reductase.


The action of glutamic acid and some derivatives on isolated supra oral sphincter preparations of the sea anemone Actinia equina.


Effect of some antihistaminic drugs on post-coital antifertility activity of oestrogens in rat.


Streptovaricins inhibit RNA dependent DNA polymerase present in an oncogenic RNA virus.


Hypnosis, depth perception and schizophrenia.


Local anaesthetic action of 3 different antihistaminics compared to procaine hydrochloride.


Data regarding the problem of physical allergies.


Factors regulating the behaviour of parasites in blood-sucking insect vectors.


Comparative pharmacological action of different antihistaminics.


Cerebral metabolic aspects in posthypothermic brain edema.


Some pharmacological properties of terbutaline (INN), 1-(3,5-dihydroxyphenyl)-2-(T-butylamino)-ethanol. A new sympathomimetic beta-receptor-stimulating agent.


A dual preparation technique for studying the differentiation of the effect of sympathomimetic agents on heart and tracheal muscle.


Circulatory effects of orciprenaline, adrenaline and a new sympathomimetic beta-receptor-stimulating agent, terbutaline, in normal human subjects.


Studies on Terbulaline, a new selective bronchodilating agent. Introductory remarks.


A comparative clinical trial of different subcutaneous doses of terbutaline and orciprenaline in bronchial asthma.


Metabolic, circulatory and respiratory effects of a new sympathomimetic beta-receptor-stimulating agent, terbutaline, compared with those of orciprenaline.


Clinical testing of fluoride and non-fluoride containing dentifrices inHounslow school children.


Beta-blocking drugs in treatment of cariac arrhythmias during anasthesia.


Transplantation, implantation, and grafts.


The association between cutaneous vasculitis and decreased blood fibrinolytic activity.


The effect of cardioselective beta-adrenergic blockade in patients with abnormal left ventricular function.


Characteristics of male homosexual college students.


Reasons physicians leave primary practice.


Development of Brugia pahangi in the jird, Meriones unguiculatus, with notes on infections in other rodents.


Histochemistry of nervous transmission.

Histochemistry of nervous transmission.


Primary cerebral arterial occlusive disease in children. I. Acute acquired hemiplegia.


The emergence of radiology as a major influence in American medicine. Caldwell Lecture, 1970.


Alpha-receptor mediated hyperglycemia in the mouse.


Some aspects of the adrenergic system of the isolated rat seminal vesicle.


Difference in 2-thenoyltrifluoroacetone sensitivity of electron transport with and against the redox potential gradient.


One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase).


Assay of hydroxylation activity in immunoprecipitates.


Panarteritis nodosa, an angiographic entity--presentation of two cases.


Trial of new bronchodilator, terbutaline, in asthma. Terbutaline, a new bronchodilator acting on beta-adrenergic receptors, was given to 10 asthmatic patients, who received on separate days 5 mg orally, 10 mg orally, and 0.25 mg subcutaneously. The ventilatory response was assessed by measurement of the FEV(1) before and at intervals after administration. The cardiovascular response was assessed by measurement of the heart rate and blood pressure and by electrocardiography at the same times as spirometry was performed.The ventilatory response to all three doses and by both routes was satisfactory. The maximal increase in FEV(1) after 5 mg orally was only slightly less than that after 10 mg. The maximal increase in heart rate after 5 mg orally was about half that which occurred after 10 mg. It is concluded that 5 mg orally and 0.25 mg subcutaneously are suitable doses.In general a modest fall in blood pressure affected the diastolic more than the systolic. On E.C.G. the T wave was often depressed, and in one patient, it was inverted. A trough-like depression of the QRS baseline occurred several times. The significance of the E.C.G. changes is uncertain.


Comparison of two oral selective beta2-adrenergic stimulant drugs in bronchial asthma. The effect of two oral selective beta(2)-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.


Ulcerative colitis. Medical management.

Ulcerative colitis. Medical management.


Studies on hydroid differentiation. VI. Regulation of hydranth formation in Podocoryne carnea.


Complications of smallpox vaccination, 1968: results of ten statewide surveys.


Stellate ganglion block in the management of tinnitus.


Effects of anaesthetic drugs on the central nervous system.


Distribution theory of resistance of neurogenic vasoconstriction to alpha-receptor blockade in the rabbit.


Beta-receptor blockade and myocardial effects of cardiac glycosides.


Studies on Culex pipiens molestus in Israel. 3. Immune reactions in laboratory animals to extracts from the mosquito.


Evidence for a lymphocytic chalone.

Evidence for a lymphocytic chalone.


For the good of the child.

For the good of the child.


The pediatricnnurse practitioner. I. Growth of the concept.


The pediatric nurse practitioner. II. Examining the role.


Guidelines onsshort-term continuing education programs for pediatric nurse associates.


The pediatric nurse practitioner in a neighborhood center.


Therapeutic abortion: a prospective study. I.


Physician's assistant--a threat or a challenge?


Evaluation of the liver adenosine 3',5'-monophosphate response to glucagon.


Boophilus microplus: antihistaminic and tranquilizing drugs and cattle resistance.


The action of anticholinergic drugs on the oxidation of indole activated by acetylcholine chloride.


Kinetics of increased vascular permeabiity induced in rat skin by serotonin.


Anesthetic implications of drugs that act on adrenergic alpha and beta receptors.


The physician's assistant: versions and diversions of a promising concept.


Treatment of atrial arrhythmias with alprenolol.


Autonomic hyperreflexia.

Autonomic hyperreflexia.


Acanthaster in the Indian Ocean.

Acanthaster in the Indian Ocean.


Research, apple juice, and daffodils--a good combination.


Neural nomenclature.

Neural nomenclature.


National conference on research in nursing practice.


MMPI scores of old and young completed suicides.


Authoritarian attitudes, degree of pathology and preference for structured versus unstructured psychotherapy in hospitalized mental patients.


Management of metabolic waste in the space environment.


Animal carotenoids. 5. The carotenoids of some Anthozoa.


Adrenergic modification of glucose-induced biphasic insulin release from perifused rat pancreas.


Dissecting thoracic aneurysm.

Dissecting thoracic aneurysm.


The critically injured patient: a plan for the organization of a statewide system of trauma facilities.


Personality descriptions of mental health center patients for use as pre-therapy information.


A structured approach to group marriage counseling.


Distribution, dose dependency, and effect of donor presensitization on liver infiltration in the graft-versus-host reaction.


Treadmill neutralization of antibody and central inhibition. Separate components of pneumococcal polysaccharide paralysis.


Tryptophan pyrrolase, tryptophan and tyrosine transaminase changes during allylisopropylacetamide-induced porphyria in the rat.


Importance of demethylenation in the metabolism in vivo and in vitro of methylenedioxyphenyl synergists and related compounds in mammals.


Model systems for aromatic nitro group reduction--relationships to tissue catalyzed reagents.


The effects of adjuvant-induced arthritis on the liver metabolism of drugs in  rats.


The effect of diet and phenobarbitone on quinine metabolism in the rat and in man.


Effect of monoamine oxidase inhibitors on the disposition of intracisternally administered metaraminol-3H.


The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro.


Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.


Steroid delta 4-reductases of pig lver: partial purification of testosterone 5 beta-reductase.


Anorchia. A variety of the "empty scrotum".


To sterilize an astronaut.

To sterilize an astronaut.


Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.


The production of interferon by animal viruses.


Reversion in cells transformed by tumour viruses.


Glycolipid synthesis in normal and transformed animal cells.


Induced cellular DNA synthesis by 'early' and 'late' temperature-sensitive mutants of polyoma virus.


The viral genome in transformed cells.

The viral genome in transformed cells.


DNA and the RNA viruses.

DNA and the RNA viruses.


SV40 specific 'repressor' in infected and transformed cells.


Novel assay of 7-alkylation of guanine residues in DNA. Application to nitrogen mustard, triethylenemelamine and mitomycin C.


Mutant strains of Chlamydomonas reinhardi with lesions on the oxidizing side of photosystem II.


Hematopoietic and immunologic tissue grafting. Current concepts and indications in pediatric patients.


Host and graft factors in the homing of haematopoietic cells.


Bone marrow chimeras in man and animals.


Observations under treatment with norethisterone-enanthate.


A soluble dihydrofolate reductase from human placenta: purification and properties.


Action of halothane upon mitochondrial respiration.


The conversion of L-lysine to saccharopine and alpha-aminoadipate in mouse.


Biosynthesis of bacterial glycogen IX: regulatory properties of the adenosine diphosphate glucose pyrophosphrylases of the Enterobacterieae.


Enzymatic synthesis of fatty alcohols in Brassica oleracea.


An experimental approach to study the toxicity of nonparticulate air pollutants. II. Effect of ozone inhalation on nadide phosphate levels in tracheal mucosa.


The effects of calcium, magnesium and manganese on dextran production by a cariogenic streptococcus.


Effect of spironolactone, norboletone, progesterone, hydroxydione and beta-diethylaminoethyl diphenylpropylacetate on the disappearance rate of indometacin from blood.


An analysis of graft-versus-host disease in Syrian hamsters. II. The epidermolytic syndrome: studies on its pathogenesis. The epidermolytic syndrome that can be obtained at will in F(1) hybrid hamsters by the cutaneous inoculation of adequate doses of parental strain lymphoid cells has been investigated to determine whether the cutaneous lesions are due to an autoimmune process arising from the severe, initial GVH reactions in the skin. It was amply demonstrated that inoculation of donor cells into the skin was of crucial importance to the development of epidermolysis. Parental strain lymphoid cells in similar doses delivered by any other route into normal F(1) hybrids failed absolutely to incite the acute syndrome. If "immune lymphocyte transfer" reactions incited by donor cells in the host's skin were surgically removed at timed intervals after inoculation, only complete excision within 24 hr prevented the appearance of epidermolysis in F(1) hybrid hosts, indicating that inoculated donor cells must remain within the confines of the skin for approximately 24 hr in order to evoke the disease, persistence for longer periods of time being unnecessary for the subsequent course of the disease. However, reconstitution experiments involving the intramuscular inoculation of suspensions containing mixtures of donor cells and host lymphoid cells, in the presence or absence of epidermal cells, unequivocally indicated that no intimate exposure of lymphoid cells to putative skin-specific antigens was essential. Similarly, the elicitation of generalized epidermolysis in F(1) hybrids irradiated with 300 r and then inoculated intravenously with donor cells casts further doubt on the pathogenic importance of the skin as a source of tissue-specific antigen. The results of subsequent experiments indicated that host leukocytes, rather than parenchymal cells of the dermis or the epidermis, were important contributors of the transplantation antigenic stimulus. Moreover, a series of experiments, using (CB x MHA)F(1) hybrid hosts that had been lethally irradiated and reconstituted with bone marrow cells from ALS-treated MHA donors, indicated that from 6 to 10 wk after reconstitution-when direct and immune lymphocyte transfer reactions showed a virtual absence of native F(1) leukocytes from the circulation-donor cells obtained from specifically sensitized MHA donors were completely ineffective in inducing epidermolysis, while equivalent lymphoid cell inocula derived from CB donors evoked the cutaneous disease irrespective of the time elapsed since reconstitution. To explain these findings it is postulated that in hamsters, the primary targets in graft-versus-host disease incited by the intracutaneous inoculation of donor cells are leukocytes originating in bone marrow or lymph node, or both.


An analysis of graft-versus-host disease in Syrian hamsters. I. The epidermolytic syndrome: description and studies on its procurement. F(1) hybrid hamsters derived from genetically disparate strains develop a severe and often lethal cutaneous disorder when inoculated intracutaneously with immunologically competent lymphoid cells from either parental strain, The disease is characterized clinically by extensive epidermal necrolysis, and histologically by a complete dissolution of the dermal-epidermal junction. The requisites for elicitation of this syndrome were determined to be: (a) the parental strains must differ from each other at a major histocompatibility locus, and (b) the donor inoculum must contain immunologically competent parental strain cells. In addition it was found that specifically sensitized cells surpassed normal unsensitized ones in their ability to elicit the disease, and that the disease can be transferred adoptively from affected to normal F(1) hosts by means of lymphoid cells. On the basis of these observations, it was concluded that the disease was immunologic in nature, and graft-versus-host in type. However, a series of critical studies failed to demonstrate that the epidermolysis had an immunogenetically specific basis, thus invalidating the provisional assumption that this lesion resulted from a direct immunologic attack upon parenchymal cells of the epidermis and dermis. With the aid of radiation chimeras, it was clearly established that typical epidermolysis could be induced in skin of the same genetic constitution as the attacking donor lymphoid cells. This paradox was taken into account by the possibility that, amid the intense local cutaneous graft-versus-host reactions, "skin-specific" antigenic determinants are bared which incite a quasi autoimmune response that in turn is responsible for the epidermolytic lesions.


Synergism of thymus and bone marrow in the production of gra a5hilgard HR: Synergism of thymus and bone marrow in the production of graft-versus-host splenomegaly in x-irradiated hosts. Graft-versus-host splenomegaly may be elicited from 500 R X-irradiated F(1) hybrid hosts if the hosts are injected with bone marrow cells and thymus cells from parental strain donors. Cells from thymus only or bone marrow only will not elicit graft-versus-host splenomegaly in these hosts. In this requirement for cells from both sources, the bone marrow cells play a nonimmunologic, proliferative role in the splenomegaly, and the thymus cells carry out the immunologic attack. Thus the mechanism of this synergism is quite different from that reported for the humoral immune response to sheep erythrocytes in which both thymus and marrow interact in the production of the specific immunologic response itself.


Fluorimetric study of enzyme kinetics in localized compartments of intact cells.


Risks of smallpox vaccination complications in the United States.


The case for continuing "routine" childhood smallpox vaccination in the United States.


The effect of beta-adrenergic inhibition on respiratory gas exchange and lung function.


Role of the inhalation therapist.

Role of the inhalation therapist.


The course of graft-versus-host reaction against some H-2 and non-H-2 target antigens.


Statistical treatment of percentage inhibitions of human dental caries incremental data.


Therapeutic conditions and outcome.

Therapeutic conditions and outcome.


Intellectual and personality characteristics of parents of autistic children.


Regulatory properties of an inorganic pyrophosphatase from the photosynthic bacterium Rhodospirillum rubrum. In Rhodospirillum rubrum, inorganic pyrophosphatase activity is observed in both the cytoplasmic and membrane fractions. The soluble enzyme accounts for about 80% of the total activity in crude extracts, and is the subject of this report. Zn(2+) is required for both activity and stability of the enzyme, which has a molecular weight of approximately 90,000 (gel-filtration determinations). The substrate is MgP(2)O(7) (2-), and free pyrophosphate (P(2)O(7) (4-)) is a strong inhibitor. Kinetic experiments indicate homotropic interactions between substrate-binding sites; these interactions are influenced by Mg(2+), which is an activator. At low concentrations of Zn(2+), the pyrophosphatase is inhibited by NADH, NADPH, and MgATP; 50% inhibition occurs at 0.4-0.7 mM. These effects are reversed by high concentrations of Zn(2+) (10(-4)-10(-3) M). The nucleotides appear to inhibit activity of the "native" enzyme through an effect on Zn(2+) binding. The R. rubrum enzyme seems to be the first known example of a bacterial inorganic pyrophosphatase subject to allosteric regulation.


The effect of a new sympathomimetic beta-receptor stimulating drug (terbutaline) on the pulmonary mechanics in bronchial asthma.


A clinical comparison of the effect of oral terbutaline and orciprenaline.


Palytoxin: a new marine toxin from a coelenterate. Palytoxin has been isolated from the zoanthids "limu-make-o-Hana" (Tentatively identified as Palythoa sp.) as a noncrystalline, chromatographically pure entity. Apart from polypeptide and protein toxins, it is the most highly toxic substance known, with a lethal dose (LD(59)) in mice of 0.15 microgram per kilogram by intravenous injection. Unlike the potent toxins batrachotoxin, saxitoxin, and tetrodotoxin which have molecular weights of 500 or less, palytoxin has an estimated molecular weight of 3300 and contains no repetitive amino acid or sugar units.


Effect of temperature on sympathetic transmission in the human fallopian tube.


Protection of hermit crabs (Dardanus spp.) from octopus by commensal sea anemones (Calliactis spp.).


Pneumococci insensitive to penicillin.

Pneumococci insensitive to penicillin.


Inhibition of pyridoxal enzymes by L-canaline.


Dental caries in young diabetics.

Dental caries in young diabetics.


Oxprenolol (Trasicor) during halothane anaesthesia in surgical patients.


The violent 4-3 MMPI personality type.

The violent 4-3 MMPI personality type.


Glutamine synthetase from Nocardia corallina.


An antisocial behavior pattern associated with a specific MMPI profile.


Hypertensive pulmonary vascular disease in rats after prolonged feeding with Crotalaria spectabilis seeds.


Ultrastructural changes induced in the liver of rats by various steroid compounds.


Comparison of the anti-arrhythmic action and beta-blocking potency of LB 46 and (--)-propranolol.


Drug allergy. II.

Drug allergy. II.


Peripheral neuropathy: etiological and clinical aspects.


Feeding and crop emptying in Glossina brevipalpis Newstead.


Polymorphism in the African edible grasshopper Homorocoryphus nitidulus (Tettigonoidea Conocephalidea) revisited.


The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis.


Screening for T-groups: thy myth of healthy candidates.


Interpersonal patterns of personality for drug-abusing patients and their therapeutic implications.


Periarteritis nodosa. (Report of a case).


Urinary steroid excretion in response to endogenous and exogenous gonadotrophin stimulation of cryptorchid testes in the pig.


The role of the phagocyte in host-parasite interactions. XXIX. Use of intact leukocytes for spectrophotometric assay of different enzymes.


Enzymatic conversion of 2-amino-4-hydroxy-6-formyl-7,8-dihydropteridine to 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine by cell-free extracts of Escherichia coli B.


Lipid peroxidation in the vitamin E deficient rat liver.


Objectives of biological pollution studies.


I. Measurements of pollution effects on living organisms. Bioassays to determine allowable waste concentrations in the aquatic environment.


Techniques for assessment of pollution effects on seabird.


Assessment of pollution effects by the use of algae.


Influence of pesticides on marine ecosystems.


II. Sublethal effects and changes in ecosystems. Assessment of the effects of pollutants on physiology and behaviour.


Ecological effects of sewage discharge in the marine environment.


Some changes in intertidal sand communities due to thermal pollution.


3. Effects of particular pollutants. Mercury pollution in Sweden with special reference to conditions in the water habitat.


The effects of heavy metals (other than mercury) on marine and estuarine organisms.


Effects of oil and oil dispersants on the marine environment.


The biological effects of radioactive waste.


IV. Prevention and monitoring. Pollution prevention.


Monitoring the marine environment.

Monitoring the marine environment.


Future research needs.

Future research needs.


On Setaria digitata, its specific characters, incidence and development in Aedes vittatus and Armigeres obturbans in India with a note on its ectopic occurrence.


Chest pain, personality and coronary arteriography: a preliminary study.


Family doctors' use of office assistants and opinions regarding nurses in primary care.


Effect of phenoxybenzamine on the relaxing response of Taenia coli.


Partial in vitro reconstruction of Japanese encephalitis virus receptor.


Polyphosphoinositides as receptor substances for certain groups of arboviruses.


Influence of pH, heat, deoxycholate and ether on arbovirus haemoagglutinin.


Interferonogenicity and other properties of partially inactivated influenza virus.


Isolation of St. Louis encephalitis virus from man in Argentina.


An antigenic comparison of strains of Coxiella burneti.


Separation of infectious canine hepatitis virus antigens: soluble antigens.


Reaction with mannan of a live Japanese encephalitis virus vaccine.


Varicella-zoster virus cultivation in cell cultures of non-primate origin.


Effect of poly I:C on parainfluenza 3 virus multiplication in WISH cells.


Differential reflex adjustments in cutaneous and muscle vascular beds during experimental coronary artery occlusion.


Relative efficacy of butaperazine and chlorpromazine in acute schizophrenia.


Isozymes of NADP-linked isocitric dehydrogenase in psoriasis and human basal cell carcinoma.


Bacterial and viral throat flora. Comparison of findings in children with acute upper respiratory tract disease and in healthy controls during winter.


Essential histidyl residues in arginine oxygenase (decarbosylating). Comparison with amino acid oxidases.


Neuraminidase activity in bacterial meningitis. The relation of neuraminidase to morbidity and mortality was examined in patients with Haemophilus influenzae, meningococcal, and pneumococcal meningitis. Ten strains of H. influenzae and eight strains of meningococci from infected cerebrospinal fluid (CSF) did not elaborate neuraminidase. Each of 27 strains of pneumococci from infected CSF elaborated both neuraminidase and N-acetylneuraminic acid (NANA) aldolase. There was no correlation between amount of neuraminidase secreted in vitro and survival of patients. Values for free and total NANA concentrations were derived from admission CSF samples of 63 patients with meningitis; 18 patients infected with Neisseria meningitidis, 10 with H. influenzae and 35 with Diplococcus pneumoniae. Mean values for total NANA were elevated in each type of bacterial meningitis; however, abnormal concentrations of free CSF NANA were detected only in 17 patients with pneumococcal meningitis. 11 of 18 patients with pneumococcal meningitis showing normal free CSF NANA concentrations were cured, whereas only 4 patients with abnormal free NANA levels survived without residua. Both coma and bacteremia occurred significantly more often among patients with elevated concentrations of free CSF NANA. The association of elevated concentrations of free CSF NANA with coma and with an adverse prognosis suggested that neuraminidase may be a factor in the pathogenesis of penumococcal meningitis.


Effect of ganglionic blockade on the responses of coronary blood flow to cardiac sympathetic stimulation in the dog.


Influence of cell dose on mortality from graft-versus-host disease.


Inhibition of the graft-versus-host reaction by thymus-specific antibodies.


Chimaerism and mortality of irradiated mice injected with allogeneic spleen and bone marrow cells.


Immunopathology; a note on the history of my study.


Rhythmicity of plasma amino acids and relation to dietary intake.


Bionomics of autogenous mosquitoes.

Bionomics of autogenous mosquitoes.


The microfilaria of Brugia: a first stage nematode larva.


Hydrocortisone resistance of activated initiator cells in graft versus host reactions.


Development of megakaryocytes in bone marrow of the rat: an analysis by electron microscopy and high resolution autoradiography.


Protection by catatoxic steroids against cyclophosphamide-induced organ lesions.


Carnarvon studies. V. Oral lactobacillus estimations of 390 caucasian school children exposed to increased fluoride content of the town water supply in Carnarvon, Western Australia (August, 1965).


Fibrocystic disease of the pancreas (mucoviscidosis). Case report.


The dental health and habits of South Australian children from different socio-economic environments.


Dental conditions observed in Australian aboriginal children resident in Warburton and Cundeelee missions, Western Australia (August, 1968).


The normal lymphocyte transfer reaction in lambs thymectomized in utero.


Homograft rejection and hypersensitivity reactions in lambs thymectomized in utero.


Teenage maternal mortality in Chicago 1956-1968.


The radiographic diagnosis of an osteoblastic metastatic disease of the bone.


Recurrent duct stones.

Recurrent duct stones.


Doctors of the people, by the people, for the people. A bold proposal for minority recruitment and medical education.


Health care delivery crisis.

Health care delivery crisis.


EKG of the month: electrocardiographic diagnosis of bundle-branch block.


Instructional effects on word association commonality in high and low "schizophrenic" college students.


Adding drugs to blood transfusions.

Adding drugs to blood transfusions.


The primary health care professional was a nurse.


Objective--a national policy on aging.

Objective--a national policy on aging.


Two views on the latest health manpower issue: expanding the nurse's role does not make her a physician's assistant.


Two views on the latest health manpower issue: physician's assistants belong in the nursing profession.


Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response.


Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. II. Studies on the relative rate of antibody synthesis and release by antibody-producing cells.


Suppressive effect of graft versus host reactions on the immune response to heterologous red cells.


The use of scanning electron microscopy in morphology and taxonomy of some mites and mosquitoes.


Production of ATP in leukocyte mitochondria from hyperthyroid patients before and after treatment with a beta-adrenergic blocker and antithyroid drugs.


On the Japanese B--West Nile virus complex or an arbovirus problem of six continents.


Isolations of Nepuyo virus strains from Honduras, 1967.


Inhibition of the growth of primary fibrosarcomas in rats with immune or non-immune spleen and lymph-node cells.


Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: delta 4-3-ketosteroid 5 alpha-oxidoreductase of rat prostate.


Protection of snails against miracidia of Schistosoma mansoni by various aquatic invertebrates.


The cultivation of Plasmodium relictum in mosquito cell lines.


Skin reaction specificity of guinea pig immediate hypersensivity to bites of four mosquito species.


Enzymes of CO2 fixation in larval and adult Moniliformis dubius (Acanthocephala).


Pneumococcal vaccine.

Pneumococcal vaccine.


Immunosuppression by alpha blockade.

Immunosuppression by alpha blockade.


Airborne microbes: their significance and distribution.


Visual identification of synaptic boutons on living ganglion cells and of varicosities in postganglionic axons in the heart of the frog.


Synaptic transmission and its duplication by focally applied acetylcholine in parasympathetic neurons in the heart of the frog.


Differential chemosensitivity of synaptic and extrasynaptic areas on the neuronal surface membrane in parasympathetic neurons of the frog, tested by microapplication of acetylcholine.


The development of chemosensitivity in extrasynaptic areas of the neuronal surface after denervation of parasympathetic ganglion cells in the heart of the frog.


Renal arteriography enhanced by tolazoline. Value in the diagnosis of polyarteritis nodosa complicated by perinephric hematoma.


Communications between community health researchers and practitioners. Evaluation of an attempt at improvement.


Immunologic studies of human group I pepsinogens.


Electronic representation of the lipophilic parameter pi.


Beta-adrenergic blocking agents. 9. Absolute configuration of propranolol and of a number of related aryloxypropanolamines and arylethanolamines.


Beta adrenergic blocking agents.

Beta adrenergic blocking agents.


Iind National Congress of Internal Medicine, Bucharest.


Bilateral interstitial hernia in the newborn infant.


The pretreatment of E. coli endotoxin shock with WR 2823: a new alpha-adrenergic blocking agent.


Glial cells in the myenteric plexus.

Glial cells in the myenteric plexus.


Effect of proteolytic and lipolytic enzymes on the electron transport particle fraction of Rhodospirillum rubrum. II. Phospholipases.


Are acidic polysaccharides involved in collagen fibril formation or stabilization?


Time course of enzyme adaptation. 3. Periodic and nonperiodic responses of rat liver enzyme activities to diets in meal-fed rats.


Pathway of carbon flow during fatty acid synthesis from lactate and pyruvate in rat adipose tissue. The metabolism of pyruvate and lactate by rat adipose tissue was studied. Pyruvate and lactate conversion to fatty acids is strongly concentration-dependent. Lactate can be used to an appreciable extent only by adipose tissue from fasted-refed rats. A number of compounds, including glucose, pyruvate, aspartate, propionate, and butyrate, stimulated lactate conversion to fatty acids. Based on studies of incorporation of lactate-2-(3)H and lactate-2-(14)C into fatty acids it was suggested that the transhydrogenation sequence of the "citrate-malate cycle"(1) was not providing all of the NADPH required for fatty acid synthesis from lactate. An alternative pathway for NADPH formation involving the conversion of isocitrate to alpha-ketoglutarate via cytosolic isocitrate dehydrogenase was proposed. Indirect support for this proposal was provided by the rapid labeling of glutamate from lactate-2-(14)C by adipose tissue incubated in vitro, as well as the demonstration that glutamate can be readily metabolized by adipose tissue via reactions localized largely in the cytosol. Furthermore, isolated adipose tissue mitochondria convert alpha-ketoglutarate to malate, or in the presence of added pyruvate, to citrate. Glutamate itself can not be metabolized by these mitochondria, a finding in keeping with the demonstration of negligible levels of NAD-glutamate dehydrogenase activity in adipose tissue mitochondria. Pyruvate stimulated alpha-ketoglutarate and malate conversion to citrate and reduced their oxidation to CO(2). It is proposed that under conditions of excess generation of NADH malate may act as a shuttle carrying reducing equivalents across the mitochondrial membrane. Malate at low concentrations increased pyruvate conversion $$Word$$ citrate and markedly decreased the formation of CO(2) by isolated adipose tissue mitochondria. Malate also stimulated citrate and isocitrate metabolism by these mitochondria, an effect that could be blocked by 2-n-butylmalonate. This potentially important role of malate in the regulation of carbon flow during lipogenesis is underlined by the observation that 2-n-butylmalonate inhibited fatty acid synthesis from pyruvate, but not from glucose and acetate, and decreased the stimulatory effect of pyruvate on acetate conversion to fatty acids.


De novo fatty acid synthesis and elongation of fatty acids by subcellular fractions of lung. Fatty acid synthesis by subcellular fractions of rabbit lung was studied by measuring the incorporation of either radioactive acetyl coenzyme A or malonyl coenzyme A into long-chain fatty acids. Evidence is presented to support the conclusions that the 95,000 g-supernatant fraction contains the enzymes, i.e., fatty acid synthetase and acetyl coenzyme A carboxylase, necessary for de novo fatty acid synthesis and is capable of synthesizing long-chain fatty acids, probably palmitic acid, under the appropriate conditions. The mitochondrial fraction incorporates the short-chain coenzyme A derivatives into fatty acids predominantly by the elongation pathway. It is suggested that the palmitic acid synthesized in vivo by the de novo fatty acid synthetic pathway, demonstrated in vitro in rabbit lung, may be a source of the lecithin palmitic acid utilized in the synthesis of pulmonary surfactant.


Rotational isomerism in Bis-(p-(3-methyl-butyloxy)-phenyl)-thiourea.


The effect of stereoisomeric structure on retention time in gas liquid chromatography of per-O-trimethylsilyl derivatives of pentoses and hexoses.


Further evidence for carotenoids engaged in a metastable state in photosynthesis.


Localization of ferredoxin in the thylakoid membrane with immunological methods.


Appearance and disappearance of phosphorylases in potatoes.


On the structure of peuarenarine, a new coumarin from Peucedanum arenarium.


Photoreactions and complex formation of retinal monolayers at a water-air interface.


The sparing effect of UV- and X-ray-fractionation in starved diploid yeast.


The juvenile hormone-like effect of farnesol derivatives on the pupal development of Cerura vinula L.


Serological behaviour of an "incomplete" and "superagglutinating" anti-A from the snail Helix pomatia.


Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat.


Evidence for the coupling of the regulations of tyrosine aminotransferase and phosphoenolpyruvate carboxykinase.


Chromatographic determination of the D- and L-amino acid residues in pneumococcal C-polysaccharide.


Alpha- and beta-adrenergic receptors as mediators of accumulation of cyclic adenosine 3',5'-monophosphate in specific areas of guinea pig brain.


Hypothalamic regulation of the daily rhythm in hepatic tyrosine transaminase activity.


Bone marrow lymphocytes: their isolation, colony-forming capacity and graft-versus-host potential. I. The isolation and characterization of subpopulations of bone marrow lymphocytes.


Attentuation of some effects of anaphylaxis by 1,18-diamino-6,13-diaza-9,10-dithiaoctadecane tetrahydrochloride (WR 149,024).


The urological assistant.

The urological assistant.


ICN statement on nursing education, nursing practice and service and the social and economic welfare of nurses.


Adapting nursing education to today's student population.


High school counselors' interpretations of nursing school programs.


Working with the foreign nurse in the United States.


Contemporary guidelines in teaching.

Contemporary guidelines in teaching.


Physician's assistant.

Physician's assistant.


International congress in Prague.

International congress in Prague.


Family nurse practitioners in Eastern Kentucky.


Physician's assistants.

Physician's assistants.


Where are we going in baccalaureate education in nursing.


The American Nurses' Association--American Medical Association dialogue on utilization of the nurse.


An expanded role.

An expanded role.


Nursing--evolution or revolution?

Nursing--evolution or revolution?


The circulatory response to hypercapnia during fluroxene anesthesia in man.


The metabolic effects of nonvolatile anesthetics on mammalian hepatoma cells in vitro. I. Inhibition of cell replication.


Dissociation of tracheobronchial and cardiac effects of some beta-adrenergic stimulants.


Systemic arterial pressure changes cased by sympathomimetic amines and influence of norepinephrine infusion on chronically reserpinized dogs.


Possible dopaminergic pathway from substantia nigra to putamen.


Modification of the pressor response to sympathomimetic amines by acutely administered reserpine in dogs.


The health care disciplines. 2 The physician assistant.


Report on occupational health nursing session ICN congress.


Fibromuscular dysplasia. Neurologic disorders associated with disease involving the great vessels in the neck.


Inner ear response to surgery in otosclerosis.


Drug abusers, suicide attempters, and the MMPI.


A bicycle-mounted trap for collecting adultmosquitoes.


Unit spike activity in the coelenteran neural network.


Activity of an NADPH-dependent nitroreductase in houseflies. A nitroreductase, reducing parathion to aminoparathion, was found in the soluble fraction that was obtained from abdomens of female houseflies. The reaction required reduced nicotinamide adenine dinucleotide phosphate (NADPH), but was not affected by the presence or absence of oxygen. Further degradation of aminoparathion into water-soluble compounds occurred in NADPH-fortified incubation mixtures over prolonged incubation periods. The effect of sesamex or SKF 525-A on these reactions is described.


The effect of methylphenidate and prolintane on the metabolism of ethyl biscoumacetate.


Some molecular properties of pneumoccal neuraminidase isoenzymes.


Caries experience of 5-year-old children living in fluoride and non-fluoride areas of Essex.


Dental caries prevalence in 5-year-old children following five and a half years of water fluoridation in Birmingham.


Dietary habits at bedtime in relation to dental caries in children.


The effect of Incidal, administered to pregnant Wistar strain rats, upon the fetuses.


Body temperature changes during organ transplantation.


Notable advances in the treatment of skin diseases 1946-1970.


The place of beta-adrenergic blocking drugs in the deliberate induction of hypotension.


Cardioversion and the anesthesiologist.

Cardioversion and the anesthesiologist.


Hemodynamic effects of propiomazine.

Hemodynamic effects of propiomazine.


Specificity of catalase degradation in C57BL mice: comparison with other liver enzymes.


Effects of three beta adrenergic receptor blockers on myocardial oxygen consumption in the dog.


Cardiovascular effects of intravenous morphine in the anaesthetized rat.


Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain.


Evidence for an alpha-sympathomimetic component in the effects of catapresan on vasomotor centres: antagonism by piperoxane.


Comparison of the effects of various betaadrenergic blocking agents with known antiarrhythmic drugs on aconitine-arrhythmia produced by the cup method.


Dermatological complications of peripheral vascular disease.


Antilipolytic activity of 4-(2-hydroxy-3-isopropylaminopropoxy) acetanilide (Practolol).


Influence of age and diet on the induction of microsomal enzymes in the mouse.


Procedure for determination of D-amino acids.


Circulating beta adrenergic stimulator during elevated cerebrospinal fluid pressure.


Haemodynamic effects of oxprenolol and practolol in dogs under halothane anaesthesia.


Nursing service.

Nursing service.


Teenager maternal mortality in Chicago (1956-1968).


The view box.

The view box.


The role of L-DOPA in the functional rehabilitation of patients with Parkinson's disease.


Ischemic colitis. A case report.

Ischemic colitis. A case report.


Molecular interactions of competitive inhibitors with bovine liver glutamate dehydrogenase.


Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.


Reaction mechanism of 17-beta-estradiol dehydrogenase determined by equilibrium rate exchange.


Glutamic dehydrogenases of Oomycetes. Kinetic mechanism and possible vvolutionary history.


The effect of controlled oral hygiene procedures on the progression of periddontal disease in adults: results after third and final year.


"Free" time for the practicing physician.


Controversy and trends in medical education. Report of the 8th annual Conference on Research on Medical Education.


Some central and peripheral effects of meclastine, a new antihistaminic drug, in man.


Effect of beta-adrenoceptor blocking compounds (propranolol, practolol and LB 46) on isoprenaline induced changes in regional blood flow in the rat. 1. The effects of three beta-adrenoceptor blocking agents on isoprenaline induced changes in systemic and regional blood flow have been investigated in rats anaesthetized with pentobarbitone. The blood flow to the principal vascular beds was measured by the (86)Rb fractionation method.2. Isoprenaline infusion at a rate of 0.3 (mug/kg)/min intravenously caused an increase in cardiac output and a decrease in peripheral resistance which affected different vascular fields unevenly. The coronary and carcass fractions of cardiac output increased while the cutaneous, renal and splenic fractions decreased.3. Pretreatment with propranolol (2 mg/kg intravenously) blocked all isoprenaline effects. Practolol (8 mg/kg intravenously) lessened the effect on cardiac output but did not prevent the vascular effects except those on the coronary circulation. LB 46 (0.2 mg/kg) had less marked beta-adrenoceptor blocking activity than propranolol (2.0 mg/kg).