The comparative effect of reserpine and carbethoxysyringoyl methylreserpate (Su 3118) upon the  menstrual cycle of the rhesus monkey.


Reductive decomposition of S-sulfoglutathione in rat liver.


Formation and metabolism of 3-beta-hydroxycholest-5-en-7-one and cholest-5-ene-3-beta, 7-beta-diol. Bile acids and steroids 192.


Biosynthesis of phosphatidic acid from dihydroxyacetone phosphate.


Inhibition of folate biosynthesis and function as a basis for chemotherapy.


The stoichiometry of NADP dependent photosynthetic phosphorylation.


Epidemiology and its application to dental disease.


Changes in fungi with age. IV. Role of coenzymes in the respiratory decreases in Rhizoctonia solani and Sclerotium bataticola.


Supersensitivity and dependence on cocaine.


The adult growth examination: preliminary comparisons of physical aging in adults by sex and race.


Analysis of items perceived as objectionable in the Minnesota Multiphasic Personality Inventory.


MMPI profiles of brain-damages and schizophrenic patients.


Strontium and quantal release of transmitter at the neuromuscular junction. 1. Previous work has shown that in calcium-free solutions nerve impulses invade the motor nerve terminals at the neuromuscular junction, but fail to release transmitter. In these conditions, strontium ions applied iontophoretically to a minute part of a junction, or to the whole muscle by bath application, restore to the nerve impulse its ability to release transmitter.2. As with calcium, the transmitter released in the presence of strontium is in the form of packages (quanta) whose release can be predicted from Poisson's Theorem.3. The mean number of quanta released by a nerve impulse increases with the concentration of strontium. Strontium is much less effective than calcium in equimolar concentrations.4. Transmitter quanta released in the presence of strontium evoke larger unit potentials than quanta released in the presence of calcium. The larger size of the Sr-unit potentials is caused by a prolongation of transmitter action, presumably due to a post-synaptic effect of strontium.5. Neuromuscular transmission was blocked in some fibres when the concentration of strontium was raised beyond 10 mM. This junctional block was presumably due to a failure in the propagation of nerve impulses.6. The post-stimulation increase in the frequency of miniature end-plate potentials, which is normally seen in calcium solutions, is also observed when calcium is substituted by strontium. The post-stimulation effect increases with the concentration of strontium.7. It is concluded that strontium can substitute for calcium in the process of quantal release of transmitter. The physico-chemical mechanism of this substitution remains unknown.


XXV. The addict physician: a Minnesota Multiphasic Personality Inventory study of the interaction of personality characteristics and availability of narcotics.


The conversion of S-n-propyl-L-cysteine into its sulphoxide by microsomal preparations from rat liver.


The stoicheiometry of electron transfer by bacterial and plant ferredoxins. 1. The number of electrons carried by ferredoxins from spinach, the blue-green alga Anacystis nidulans, the anaerobic bacterium Clostridium welchii and the photosynthetic bacterium Chromatium was determined. 2. Ferredoxins were reduced by illuminated chloroplasts, and the stoicheiometry of the reoxidation in the dark of the ferredoxins by NADP and benzyl viologen was measured. 3. Spinach and A. nidulans ferredoxins were found to be one-electron carriers, and Cl. welchii and Chromatium ferredoxins were two-electron carriers.


The bacterial metabolism of 2,4-xylenol. 1. Measurements of the rates of oxidation of various compounds by a fluorescent Pseudomonas indicated that metabolism of 2,4-xylenol was initiated by oxidation of the methyl group para to the hydroxyl group. 2. 4-Hydroxy-3-methylbenzoic acid was isolated as the product of oxidation of 2,4-xylenol by cells inhibited with alphaalpha'-bipyridyl. 3. 4-Hydroxyisophthalic acid accumulated at low oxygen concentrations when either 2,4-xylenol or 4-hydroxy-3-methylbenzoic acid was oxidized by cells grown with 2,4-xylenol. 4. When supplemented with NADH, but not with NADPH, cell extracts oxidized 4-hydroxy-3-methylbenzoic acid readily. 2-Hydroxy-5-methylbenzoic acid was not oxidized. 5. Both 4-hydroxyisophthalic acid and p-hydroxybenzoic acid were oxidized to beta-oxoadipic acid by cell extracts supplemented with either NADH or NADPH. 4,5-Dihydroxyisophthalic acid was not oxidized. 6. From measurements of oxygen consumed and carbon dioxide evolved it was concluded that protocatechuic acid is an intermediate in the conversion of 4-hydroxyisophthalic acid into beta-oxoadipic acid.


On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.


Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate. 1. Pneumococcal C-substance was isolated from the non-capsulated Pneumococcus 1-192R, A.T.C.C. 12213, by extraction with trichloroacetic acid solution followed by chromatography on DEAE-cellulose (HCO(3) (-) form). 2. The polymer contains 7.0% of phosphorus and 6.0% of nitrogen and is composed of phosphate, N-acetyl-d-galactosamine, d-glucose, N-acetyldiaminotrideoxyhexose, ribitol and choline in the molecular proportions 2:1:1:1:1:1. 3. After acid hydrolysis, d-galactosamine hydrochloride and galactosamine 6-phosphate were isolated in crystalline form and crystalline derivatives of d-glucose and anhydroribitol were obtained. A product of partial acid hydrolysis was provisionally characterized as 6'-O-phosphoryl-[O-beta-d-galactosaminyl-(1'-->6)-d-glucose]. 4. C-substance contains free amino groups accessible to attack by 1-fluoro-2,4-dinitrobenzene and nitrous acid. 5. Choline phosphate and ribitol phosphate are units in the polymer. 6. Treatment with hot alkali gave a fragment comprising phosphate, d-galactosamine, d-glucose, diaminotrideoxyhexose and ribitol in the molecular proportions 2:1:1:1:1. 7. After selective N-acetylation, the fragment contained one of its phosphate groups as a phosphomonoester and one as a phosphodiester, shown by potentiometric titration and by treatment with a phosphomonoesterase. 8. C-substance from seven other strains of Pneumococcus possesses a structure common to that described for the strain 1-192R. 9. Capsular materials from 26 different strains of Pneumococcus were analysed for suspected contamination by C-substance. In 19 cases the presence of C-substance with the normal structure was demonstrated, and in the remaining seven cases the contaminating C-substance was probably similarly constituted. 10. F-substance was isolated and the associated fatty acid material analysed.


Guidance in nursing education.

Guidance in nursing education.


Some studies on cytisine and its methylated derivatives. 1. In mice cytisine hydrochloride is less toxic intravenously than nicotine hydrogen tartrate, but more toxic by intraperitoneal or oral administration. Compared with cytisine, caulophylline hydrogen iodide is one-fifth to one-tenth as toxic and caulophylline methiodide is less than one-thirtieth as toxic.2. The surprising low oral toxicity of cytisine and nicotine may be ascribed to the method of administration; if the drug is placed directly in the stomach there is no possibility of absorption through buccal mucous membranes.3. The peripheral effects of nicotine, cytisine and caulophylline are similar, though on some preparations those of nicotine last longer. In most tests cytisine is active in doses from a quarter to three-quarters of those of nicotine, caulophylline in doses from 10 to 20 times those of cytisine. Caulophylline methiodide is virtually inactive.4. Cytisine and caulophylline may differ from nicotine in their central effects.5. Cytisine and caulophylline are active as the cations. The pKa of cytisine is 7.92 and that of caulophylline is 7.04; the difference accounts, in part, for the weaker activity of caulophylline. The caulophylline ion is generally one-sixth to one-third as active as the cytisine ion.6. The introduction of the second methyl group to form the quaternary salt does not appear to cause a dramatic change in the conformation of the molecule. Caulophylline methiodide appears to be feebly active because it has feeble affinity.


Spontaneous and evoked release of neurotransmitter substances in the longitudinal muscle of the anterior mesenteric artery of the domestic fowl. 1. Changes in length of the longitudinal muscle of the anterior mesenteric artery of the domestic fowl (LMAMA) were recorded isotonically.2. The actions of physostigmine and hyoscine suggest that the tone of the LMAMA is dependent on a resting release of acetylcholine within the tissue.3. Catecholamines inhibited the contractions obtained in response to stimulation of cholinergic nerves; this was a beta-receptor effect. After beta-receptor blockade, noradrenaline, but not isoprenaline, weakly facilitated the effects of stimulating cholinergic nerves.4. In the presence of hyoscine, nicotine relaxed preparations of the LMAMA in which the tone had been raised with barium chloride. These relaxations were considered to be due to a release of catecholamine probably from sympathetic nerves.


The use and misuse of behavioral science in nursing education.


The many facets of continuing education in nursing.


Selective metabolism of cyclodiene insecticide enantiomers by pig liver microsomal enzymes.


Effect of oral ethamivan on daily fluctuations of carbon dioxide tension in pulmonary emphysema with carbon dioxide retention.


Red cell enzymes glucose-6-phosphate dehydrogenase deficiency.


Castration of abdominal cryptorchid horses by a paramedian laparotomy approach.


Uterine bleeding in Rhesus monkeys after intrauterine contraceptive device insertion: effect of antihistaminic drugs.


Distribution of tricarboxylic acid cycle enzymes and glyoxylate cycle enzymes between mitochondria and peroxisomes in Tetrahymena pyriformis.


Perceptual illusions and brain models.

Perceptual illusions and brain models.


Are there structural alterations in synapses related to functioning?


Outlines of a theory of visual pattern recognition in animals and man.


The non-local storage of temporal information.


Experiments on the r.n.s. (real nervous system) and monkey memory.


The unification of neural activity.

The unification of neural activity.


Encoding the unexpected.

Encoding the unexpected.


A computer model for the perception of syntactic structure.


Unique envelope of a jellyfish ovum: the armed egg. The eggs of Bougainvillia multitentaculata are spawned with an envelope consisting of a single layer of cnidocvtes. The cnidocytes are surficial On eggs, cleavage stages, and young blastulae. During gastrulation, the cnidocytes are Incorporated intO the ectoderm and become an integral part of the planula.


The fight against smoking in children. The role of the physician.


Evaluation of Israel dental health: an epidemiologic study.


Doctors, patients and tranquilizers--recent developments.


Automotive injury and the practicing physician.


Hypertension and ileus; case presentation.


Washing machine dialysis with a new twin coil kidney.


Liability of physicians in committing patients to mental hospitals.


Studies on the effects of centrophenoxine on bioelectrical activity of the rabbit brain.


The effect of antidepressant drugs and cocaine on the self-stimulation in rats.


The influence of some MAO inhibitors and neuroleptics on enzymes concerned in GABA metabolism.


Ubiquinone and NADH oxidation in the isolated rat liver mitochondrial membranes.


Ganglionic blockade by a nitrogen mustard analog of hexamethonium.


An electron microscopic observation on Diplococcus-shaped vesicles in papillary muscle of rat heart.


Movement of choline between the blood and cerebrospinal fluid in the cat.


Intensive cardiac care. Two years experience.


Simultabeous adenocarcinoma of the esophagus and stomach.


Blockade of ovulation in the rat initiated by an antimetabolite.


Medical progress in artificial insemination.


Single daily dosage of griseofulvin in fungus diseases.


Kinins--a potent biologic agent.

Kinins--a potent biologic agent.


Pulmonary embolism and renal failure.

Pulmonary embolism and renal failure.


New alcoholic treatment program developed.


The perils of immobility. A first-person case report.


Poisoning as a serious problem.

Poisoning as a serious problem.


Japanese encephalitis studies in Vellore, South India. I. Virus isolation from mosquitoes.


A new probably X-linked inherited syndrome: congenital muscular torticollis, multiple keloids cryptorchidism and renal dysplasia.


Complications of inguinal hernia in infants and children.


Serum isocitric dehydrogenase. UV method with NADP.


The analysis of quantitative inheritance simultaneously with twin and family data.


On the occurence of the alpha isomer of diphosphopyridine nucleotide and on the dehydrogenases activated by it, in leucocytes and neoplastic tissues. A metabolic error.


Chemotaxis of human eosinophils.

Chemotaxis of human eosinophils.


Stabilized flavin radical in chloroplast NADP+ reductase.


Butaperazine in chronic schizophrenic patients: a doubled-blinf study.


Solubilization of griseofulvin by nononic surfactants.


A note on the stability of emulsions at high dilution.


The solubility of sulphadiazine in water-dimethyl-formamide mixtures.


A note on the evaluation of results from creep tests using a computer.


A high content (minus)-deguelin concentrate from a commercial derris resin by steady-state distribution.


Quantitative method for determining aminofurantoin.


Simulation methods in drug screening.

Simulation methods in drug screening.


Some pharmacological effects of 1,2,3,4-tetrahydro-2-naphthylamine (beta-tetra) and its secondary N-alkyl derivativex.


Observations on the efficacy of oral hyoscine N-butyl bromide.


Metabolic effects induced by the interaction of reserpine with desipramine.


The guinea-pig isolated vas deferens: a method for increasing sensitivity to drugs.


The effect of probenecid on the elimination from CSF of intraventricularly injected 5-hydroxyindolecetic acid in normal and hydrocephalic dogs.


Cortisone acetate crystal forms.

Cortisone acetate crystal forms.


A further application of the open-ended capillary method for measuring diffusion coefficients.


The effect of promethazine on the antinociceptive actions of some narcotic analgesics.


Tolerance experiments with barbitone-dependent rats.


Moisture permeation through polymer films.


The assay of Rauwolfia cumminsii by quantitative thin-layer chromatography. (African Rauwolfia species-XII).


Antihypertensive agents.

Antihypertensive agents.


Pressure sensitive devices for denervated hands and feet. A preliminary communication.


Antihistamines.

Antihistamines.


Dental health of Israeli children.

Dental health of Israeli children.


Pedodontics in Ghana.

Pedodontics in Ghana.


MMPI correlates of Negro acculturation in a northern city.


Oral characteristics of phenylketonuric children.


Necrotizing vasculitis without visceral involvement. Postmortem examination of three cases with affection of skeletal muscles and peripheral nerves.


Chironex fleckeri ("sea wasp") sting.

Chironex fleckeri ("sea wasp") sting.


Tyramine effects before and after isoproterenol on the isolated reserpinized heart.


Mechanism of enzyme action--an approach through the study of slow reactions.


Why do we go where we go?

Why do we go where we go?


Human skin in relationship to mosquito attraction and repulsion.


Nephroangiography in periarteritis nodosa. Report of a case.


Arbovirus isolations from mosquitoes collected in Waycross, Georgia, 1963, during an outbreak of equine encephalitis.


Microdetermination of D-amino acids and D-amino acid oxidase activity with 3,methyl-2-benzothiazolone hydrazone hydrochloride.


A colorimetric method for the quantitative determination of reduced pyridine nucleotides (NADPH and NADH).


European Congress in Munich; May 11-14, 1968.


The prediction of success in a collegiate program of nursing.


The stability of vocabulary in schizophrenics.


Severe measles in the tropics. II.

Severe measles in the tropics. II.


Perinatal leukemia with a possible variant of the Ellis-van Greveld syndrome.


Fifty-year-old Caucasian man with muscle pains.


Studies on the occurrence of N-demethylase activity in adrenal and hepatic preparations from guinea pigs and rats. The effect of various substances on the magnitude of this activity.


Tyramine, catecholamines and the action of vasopressin on stimulation of water efflux in toad bladders.


Control of gluconeogenesis in biotin-deficient rat liver.


Evaluation of antideppressant properties of A-10,749.


Effect of glucagon, insulin, and thyroxine on tyrosine transaminase and tryptophan pyrrolase of rat liver.


Semiquantitative assay of erythrocyte glucose-6-phosphate dehydrogenase activity by a new modification of the Motulsky test.


Dr. Samuel Van Meter and the Illinois Medical Infirmary, 1857-1877.


Evidence of catecholamine mediation in the "aberrant" behaviour induced by lysergic acid diethylamide (LSD) in the rat.


Rumberg B, Siggel U, Witt HT: Further evidence for a new function unit of photosynthesis.


Effect of hypothermia on leukocytic phagocytosis in rabbits.


Pneumococcal septicemia presenting as a hypopyon.


Reconstitution of enzymatically active particles from inactive soluble elements in Escherichia coli K 12.


Evaluation of the coronary suspect.

Evaluation of the coronary suspect.


Celiac artery stenosis.

Celiac artery stenosis.


Two-year experience with electro-convulsive therapy in a semi-rural hospital.


Medical management of acute alcoholism.

Medical management of acute alcoholism.


Current concepts of toxemia of pregnancy.


Illinois Department of Public Aid. Payment procedures and policies explained. 3.


Placental extract effective in arthritis.


Laser systems. Recent legislation, users, and risks.


Are we dehumanizing human relations?

Are we dehumanizing human relations?


Abortion: Jewish law and the law of the land.


An automated repellency assay system. II. A new electronic "Bitometer-timer".


Aliphatic amines against insecticide-susceptible and resistant strains of Culex pipiens quinquefasciatus and Anopheles albimanus.


The use of sulthiame ("Ospolot") in the epileptic child with the hyperkinetic syndrome.


Clinicopathologic conference No. 121. Maculopapular rash and proteinuria.


Epidemiologic investigations relating to a case of eastern equine encephalitis in a Trinidadian horse.


Nicotinamide-adenine dinucleotide pyrophosphatase of Cambaroides japonica.


Relationship between the interconversion of cytochrome P-450 and P-420 and its activities in hydroxylations and demethylations by P-450 oxidase systems.


Free-radical mechanism by which triphenyltetrazolium chloride stimulates aerobic oxidation of NADPH by microsomes.


Nicotinamide cofactors of intact chloroplasts isolated on a sucrose density gradient.


Inhibitory action of oxaloacetate on succinate oxidation in rat-liver mitochondria and the mechanism of its reversal.


Insulin inhibition of tyrosine transaminase degradation in the isolated, perfused rat liver.


Electrophysiological aspects of the action of antiarrhythmic drugs.


Catharanthus alkaloids. 18. Isolation of hörhammerinine, a new alkaloid from C. lanceus (Apocynaceae).


Uptake of polynucleotides by intact mammalian cells (IV): synthetic homoribopolynucleotides.


Cryptorchidism. Roentgenological and surgical aspects.


The correlation between tick-borne encephalitis virus yeild and interferon production and effect in cell cultures of different in vitro age.


Plaque production by group A arboviruses. II. Enhancing effect of DEAE-destran on plaque numbers in chick embryo cells.


Transformation of dog kidney cells infected with SV 40 and SV 40-adeno 7 hybrid virus.


Multiplication and distribution of attenuated pseudorabies virus in the organism of vaccinated pigs.


The inhibitory effect of certain arboviruses on Shope fibroma formation.


Studies on the pathogenesis of Aujeszky's disease. II. The distribution of virus after subcutaneous infection.


A microagglutination technique for detection and measurement of rickettsial antibodies.


Interferon induction by human adenovirus in vivo.


Threshold of viraemia in Apodemus flavicollis for infection of Ixodes ricinus with tick-borne encephalitis virus.


Active interferonogenesis in the absence of amino acids from culture media and its inhibition by lactalbumin hydrolysate.


Nutrition and the growth of human adenovirus type 1 in monkey cell cultures: the importance of arginine.


Infectious rhinovirus RNA in susceptible and non-susceptible tissue culture systems.


A case of polyarteritis developing after carbenoxolone therapy.


n-decane dehydrogenation by a cell-free extract of Candida rugosa.


Effect of farnesyl methyl ether on reproductive physiology in the cockroach, Byrsotria fumigata (Guérin).


Absorption and fluorescence properties of some basic dyes complexing with nucleosides or nucleic acids.


Light scattering and viscosimetric studies on DNA after the photoreaction with some furocoumarins.


Amylase activity during germination of gamma-irradiated castor seeds.


On the x-ray inactivation at various temperatures of trypsin in dry state and aqueous solution.


A study of the combined role of viruses, mycoplasmas and bacteria in adult pneumonia.


Histochemical studies of the organon vasculosum laminae terminalis of the adult rabbit.


The platelet acquires a personality.

The platelet acquires a personality.


Effects of hypothermia and pronethalol on ionic correlates of ouabain arrhythmias in dogs.


Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).


Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta.


Comparative metabolism of rickettsiae and other host dependent bacteria.


Maternal effect on reproductive capacity of irradiated female mice.


Protein synthesis during the first three cleavages in pond snail eggs (Lymnaea stagnalis).


OStudies on organophosphorus insecticides 3. On the properties of soma alpha-hydroxy phosphonates and related compounds.


The adrenergic transmitter of the female reproductive tract: distribution and functional changes.


Mechanism of aliphatic hydroxylation. Tetralin hydroperoxide as an intermediate in the hydroxylation of tetralin in rat-liver homogenate.


Oxidation of n-hexadecane by subcellular preparations of guinea pig small intestine.


The inhibition of the fatty acid synthetase multienzyme complex of yeast by long-chain acyl coenzyme A compounds.


Kinetic study on the oxidation of L-proline by D-amino-acid oxidase.


Structure and function of D-amino-acid oxidase. 3. Chemical modification of D-amino-acid oxidase caused by glyoxal.


Monomer-dimer equilibrium of D-amino-acid oxidase apoenzyme.


Enzymic differentiation in mammalian liver injection of fetal rats with hormones causes the premature formation of liver enzymes.


Yeast genetics.

Yeast genetics.


Behavioral sciences and the medical school.


Studies on dog heartworm in South Texas.


Effects of diaphenylsulphone (dapsone) against Plasmodium vivax of South West Pacific origin.


Systematic oscillations in metabolic activity in rat liver and hepatomas. Survey of normal diploid and other hepatoma lines.


Testosterone synthesis in vitro by surgically cryptorchid testes of the rat.


Defensive style and discrepancy between self-report and physiological indexes of stress.


Immunofluorescence in the diagnosis of acute bacterial meningitis: a cooperative evaluation of the technique in a clinical laboratory setting.


Neonatal respiratory depression secondary to maternal analgesics, treated by exchange transfusion.


Cholinergic synaptic potentials and the underlying ionic mechasims.


RNA polymerase mutants of Escherichia coli. I. Mutants resistant to streptovaricin.


Jejunal biopsy findings in healthy young men.


Dehydrogenase activity and gastric secretion in gastritis.


Microangiopathic hemolytic anemia in ulcerative colitis: report of a case.


Isolations of an arbovirus of the Bunyamwera group (Tensaw virus) from mosquitoes in the Southeastern United States, 1960-1963.


Enzymic degradation of lignin. V. The effect of NADH on the enzymic cleavage of arylalkylether bond in veratrylglycerol-beta-guaiacylether as lignin model compound.


Control of rat liver aromatic amino acid transaminases by glucagon and insulin.


A psychiatric study of atypical facial pain.


Diethylstilbestrol effect on the in vitro synthesis of progesterone in the bovine corpus luteum.


Fatal hemorrhage following tracheostomy.


Formation of polysaccharides by hydra from substrates produced by their endosymbiotic algae.


Neuropathological correlates of neurological impairment following prolonged decompression.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1969.


Oesophageal and anaphylaxis and pharmacological actions.


Resistance to experimental bacterial pneumonia and influenza infection in space cabin environment.


Manned test of a regenerative life support system.


Pharmacology of 2 aminoethyl-3-phenyl norcamphane. I. Action on central nervous system.


Pharmacological studies of a new antiinflammatory compound, 2-phenyl-6-dimethylamino-6H-cycloheptoxazole.


Further pharmacological investigations of 2-aminoethyl-3-phenyl norcamphane dydrochloride. 2. Action on cardiovascular system.


Toxicity and metabolism of drugs in relation to dietary protein.


Intracellular localization and co-factor requirement of nitroreductase in rat liver.


Inhibition of cortisol metabolism in vitro by 2-methylnaphthoquinone (menadione): a possible interpretation of the potentiation of cortisol activity in vivo.


Hypnotic-like experiences in a large general population related to personality inventory responses.


P-hydroxybenzoate hydroxylase: conformational changes in crystals of holoenzyme versus holoenzyme-substrate complex.


Metabolic effects produced by alcohol in the liver and other tissues.


Effect on dental caries of topically applied acidulated phosphate-fluoride: results after two years.


Acute effects of digoxin intoxication on rat hepatic and cardiac cells. Structural and functional changes in the endoplasmic reticulum.


Meniere's disease and the medical treatment of vertigo.


6-phosphogluconate dehydrogenase in cell free extracts of Escherichia coli K-12.


Xanthone derivatives with centrally stimulating and analeptic activities.


Synthesis and pharmacological properties of some 5H-benzo(4,5)cyclohepta(1,2-b)pyridine derivatives.


[The pharmacological actions of butidrine. A comparative study of this new beta-adrenergic receptor antagonist and its four stereoisomers].


A new method for preparation of nicotinamide-adenine-dinucleotide phosphate from Saccharomyces cerevisiae.


On the central action of alkyl derivatives of butyrolactone.


The effect of some psychopharmacological agents, pronethalol and atropine on the vasodilatation of the eye bulb of rabbit due to local application of reserpine and tolazoline.


Pharmacology of new tropine ethers with central activity.


Interactions of polynucleotides and their components. 3. Spectrophotometric study of the thermodynamic values involved in poly A--poly U interactions.


Interactions of polynucleotides and thier components. I. Dissociation constants of the bases and their derivatives.


On the fate of methanol and ethanol in the adult larva of the cotton leaf worm (Prodenia litura F).


Postinfusion phlebitis in infants and children. How to avoid this complication.


Comparative studies on adaptive enzymes in rat liver. 3. Effects of malignant tumor.


Metabolic control and membranes.

Metabolic control and membranes.


Pharmacological and behavioral characteristics of 3-4, dimethoxyphenylethamine and its n-acetyl derivative.


Single presynaptic neurone mediates a two component postsynaptic inhibition.


Enzymatic mechanism of steroid hydroxylation.


Ontogeny of soluble and mitochondrial tyrosine aminotransferases. The development of the soluble and mitochondrial forms of tyrosine aminotransferase was observed in fetal and neonatal rhesus monkey tissues. The mitochondrial activity is detectable in early fetal life; the soluble form reaches significant activity just before the birth of the animal.


The acute hemodynamic changes of beta-adrenergic blockade in patients with thyrotoxicosis.


Fluctuations in haptoglobin levels after minor surgical operations.


Studies on the mechanism of immunokinetics of the tuberculous process. I. Action of the antagonists of histamine and serotonin.


The effects of exogenous histamine on the pulse rate in pregnant and non-pregnant women before and after inhibition of histaminase.


Hypervolemia during ganglionic blockade hypotension.


Tyrosine aminotransferase: activation or repression by a stress.


The lack of hydrate formation at a temperature of 0 C of methoxyflurane, halothane, diethyl ether and fluroxene.


Reports of scientific meetings.

Reports of scientific meetings.


Acute toxicity and general pharmacologic properties of 1,5-dimorpholino-3-(1-naphthyl)-pentane: DA 1686.


Further studies on lidoflazine (R-7904).


Investigation of the elimination of bamethanesulphate in the cat.


An investigation of the inhibitory transmitter substances in the heart of the mollusc Tapes Watlingi.


Gastric motor-stimulating activity of gastrin tetrapeptide in dogs.


Selected physiological and psychomotor correlates of depression in psychiatric patients.


Reconstructive surgery of the foot of a rhesus monkey (Macaca mulatta).


Coronary care conference.

Coronary care conference.


Prediction of sickness in Naval recruits by Minnesota Multiphasic Personality Inventory scores.


A controlled study of three respiratory stimulants in chronic respiratory failure.


Relationship between age and properties of human and rabbit erythrocyte glucose-6-phosphate dehydrogenase.


Profiles of burn management. V. Complications associated with burns.


Conference summary and interpretation.

Conference summary and interpretation.


Nucleic acid and protein synthesis and pattern regulation in hydra. I. Regional patterns of synthesis and changes in synthesis during hypostome formation.


Marine pharmaceuticals.

Marine pharmaceuticals.


Nucleic acid and protein synthesis and pattern regulation in hydra. II. Effect of inhibition of nucleic acid and protein synthesis on hypostome formation.


Giant cyst of the utricle.

Giant cyst of the utricle.


The active chlorophyll-a-II in light reaction II of photosynthesis.


Ipsilateral thigh flap for total plantar resurfacing. Case report.


Effects of some organic phosphate compounds on the oxyhemoglobin dissociation curve in human erythrolysate.


Arbovirus studies in south Florida, with emphasis on Venezuelan equine encephalomyelitis virus.


Gumbo Limbo, a new group C arbovirus from the Florida everglades.


Attacks on cattle by mosquitoes and biting midges.


Effects of centrophenoxine on electrical activity of the rabbit brain in sodium cyanide intoxication.


Atopic erythroderma with bilateral cataract, unilateral keratoconus and iridocyclitis, and undescended testes.


WHO in Boston.

WHO in Boston.


Eosinophils and dietary histamine in the rat.


A rapid clinical method for the estimation of activity of aconitase in blood.


Conceptual objectives for a model course in psychopharmacology in psychiatric education.


The computer and the clinical decision process. II.


The current status of computer interpretation of psychological tests.


The vascular response to mild thermal injury to the rat tongue.


Serum enzymes in combat casualties.

Serum enzymes in combat casualties.


Tyrosine transaminase degradation in perfused liver after inhibition of protein synthesis by cycloheximide.


Healing mechanism of tooth extraction wounds in rats. II. Histochemical observations on hydrolytic and oxidative enzymes in tooth extraction wounds in the rat.


Enzymic oxidation of D-1-aminopropan-2-ol by diol dehydrogenases of microbial origin.


Orthopaedic aspects of war wounds in South Vietnam.


Comparative studies on adaptive enzymes in rat liver. II. Effects of altered thyroid function.


Comparative effects of thyrotropin and long-acting thyroid stimulator on thyroidal intermediary metabolism: relationship to pyridine nucleotide levels.


A new approach to safe obstetrical sedation-analgesia: a controlled study.


Vasculitis presenting as otitis media.

Vasculitis presenting as otitis media.


A psychologic study of patients referred to a medical diagnostic clinic.


Chlorcyclizine produced cleft palate in the ferret.


Comparative aspects of muscle.

Comparative aspects of muscle.


Immunity to the venom of the sea wasp Chironex fleckeri.


Enzymatic deiodination of diiodotyrosine; possible mediation by reduced flavin nucleotide.


Effect of sympathetic blocking agents on the uterine response to estrogen.


Follicular fluid kinin and its action on fallopian tube.


Reduction by progesterone of the estrogen-induced increase in transmitter level of the short adrenergic neurons innervating the uterus.


Electron microscopic localization of 5-hydroxydopamine, a 'false' adrenergic neurotransmitter, in the autonomic nerve endings of the rat pineal gland.


A steroid inhibitory effect on adrenal mitochondria.


Spontaneous hypertension in rats.

Spontaneous hypertension in rats.


Medications in pulmonary insufficiency due to restrictive ventilatory impairment and alveolar-capillary block syndrome.


Nesidioblastosis in familial endocrine adenomatosis.


Common dermatologic conditions seen by the pediatric allergist.


Management of the child with allergic asthma and rhinitis.


The effect of pH on mast cell damage by antihistamines.


Purification of a toxin from tentacles of the anemone Condylactis gigantea.


Equine cryptorchidism.

Equine cryptorchidism.


Release of an acetylcholine-like substance from guinea pig ileum by scorpion venom.


Regulation of fatty acid synthesis.

Regulation of fatty acid synthesis.


Guanethidine and bethanidine in the management of hypertension.


Geographical distribution, vectors, and life cycle of Dirofilaria immitis.


Estimations of pulmonary surface activity in sedentary and exercised rats.


Dissociation of hemolytic and lymphocyte-transforming activities of streptolysin S preparations. The ability of streptolysin S preparations to induce high percentages of transformation in human peripheral blood lymphocytes was confirmed in a series of apparently healthy donors. Transforming activity was not demonstrated in the two media used for streptolysin S production, nor in control preparations in which a strain each of Streptococcus viridans, Staphylococcus aureus (nonhemolytic), and Diplococcus pneumoniae was substituted for the beta hemolytic streptococcal strain used for streptolysin S production. The relation of the hemolytic activity to the lymphocyte transforming activity of streptolysin S preparations was studied by means of inactivation and fractionation experiments. Heating produced a loss in both activities, but more in the hemolytic than in the transforming activity. The transformation obtained with a heated preparation had a high degree of correlation with that obtained with the unheated preparation in a series of normal subjects and patients with various rheumatic diseases, whose lymphocytes were often less responsive to stimulation with streptolysin S preparations (both heated and unheated) than the lymphocytes of the normal subjects studied. Treatment of streptolysin S preparations with chymotrypsin, vegetable lecithin, or trypan blue (the latter in minute amounts) resulted in preparations with no detectable hemolytic activity but with undiminished lymphocyte transforming activity. Chromatographic fractionations on DEAE-Sephadex columns yielded fractions endowed with transforming but not with hemolytic activity, and other fractions endowed with hemolytic but not with transforming activity. The recovery of the hemolytic activity was not complete and quantitation of the recovery of the transforming activity was not attempted. These experiments indicate that the hemolytic and transforming activities of streptolysin S preparations are independent of each other, and specifically that they are the attributes of two different streptococcal products, one of which is streptolysin S. The other is a nonhemolytic streptococcal product present in streptolysin S preparations but previously unrecognized. Some implications of these findings are discussed.


Guidelines for the use of adrenal corticosteroids and antihistamines in allergy.


Management of drug allergy.

Management of drug allergy.


Treatment of allergic emergencies.

Treatment of allergic emergencies.


Treatment of urticaria and physical allergy.


Contamination of mars.

Contamination of mars.


Hydra viridis: inhibition by the basal disk of basal disk differentiation. When the basal dist of Hydra viridis is excised, a new disk is regenerated. A basal disk grafted on an animal regenerating its own disk can suppress this regeneration. The effect is reversed if the grafted basal disk is subsequently excised. For inhibition to occur, the grafted disk must be present for at least 3 hours, beginning no later than 2 hours after amputation. The results indicate that the basal disk participated in the control of its own differentiation.


A comparison of the actions of different bronchodilators in asthma.


The reaction mechanism of p-hydroxybenzoate hydroxylase and a role of the substrate as an effector.


A soluble aerobic reduced nicotinamide-adenine dinucleotide (phosphate) azoreductase.


Allergic vasculitis: clinical and histological features and incidence of renal involvement.


A new metabolic pathway: biosynthesis of alkyl ether bonds from glyceraldehyde-3-phosphate and fatty alcohols by microsomal enzymes.


Studies in the enzymology of glutathione metabolism in human erythrocytes. Spectrophotometric assay methods are described for glutathione synthetase, gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase of erythrocytes. The contents of these enzymes in normal human erythrocytes are reported. Erythrocyte glutathione synthetase is inhibited by ADP; this inhibition is competitive with respect to ATP. gamma-Glutamylcysteine synthetase is subject to feedback inhibition by GSH, and is also inhibited by NADH, and to a lesser extent by NAD(+) and NADPH. This enzyme is irreversibly inactivated by cysteamine.


Control of tyrosine-alpha-ketoglutarate transaminase synthesis in rat liver: studies of superinduction in force-fed rats.


Cerebral blood flow in neurolept-analgesia.


Protective action of anaesthetics against anoxia.


Neonatal resuscitation.

Neonatal resuscitation.


A simple ultramicro method for determination of pyridine nucleotides in tissues.


Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.


Intracellular recordings in chronic focal epilepsy.


Nicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase.


Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium.


Maintenance of pregnancy after implantation in hypophysectomized or ovariectomized mice treated with phenelizine derivatives.


Glucose 6-phosphate dehydrogenase from brewers' yeast (Zwischenferment). 3. Studies on the subunit structure and on the molecular association phenomenon induced by triphosphopyridine nucleotide.


Caries incidence among cerebral-palsied children.


Oral status of Singapore youths.

Oral status of Singapore youths.


Scandinavian Symposium in Periodontology 1967.


Implant dentistry at the 1958 meeting of the Federation Dentaire Internationale.


The fourth Dental Students Conference on Dental Research.


Financial records for advertising and exhibit income.


National nutrition survey completed in Texas.


A psychoendocrine study of pregnancy and puerperium.


Silver Bay reports, following ten years of fluoridated water.


Distribution of D-aspartate oxidase in liver and kidney of various mammals.


The functional significance of changes in activity of the enzymes, tryptophan pyrrolase and tyrosine transaminase, after induction in intact rats and in the isolated, perfused rat liver.


Tyramine-H3: deaminated metabolites in neuroblastoma tumors and in continuous cell line of a neuroblastoma. Neuroblastoma tumors, as well as cultured cells of neuroblastoma, contain high monoamine oxidase activity. The major deaminated metabolite of tyramine-H(3) in the incubation mixtures with the tumors or with the cultured cells is p-hydroxyphenylacetaldehyde. Upon addition of reduced nicotinamide-adenine dinucleotide phosphate, the aldehyde was further metabolized by the reductive pathway to p-hydroxyphenylethanol, whereas upon addition of nicotinamide-adenine dinucleotide phosphate the aldehyde was only metabolized to a minor extent by the oxidative pathway to p-hydroxyphenylacetic acid. Aldehyde dehydrogenase activity is very low in the neuroblastoma tumors and in the cultured neuroblastoma cells. The generation of aldehydes and alcohols by the action of monoamine oxidase suggests that the deaminated metabolites of biogenic amines might exhibit some toxic effects in neuroblastoma patients.


Roles of denial in chronic hemodialysis.


Conversion of testosterone to delta4-androstene-3,17-dione by house cricket (gryllus domesticus) male gonad preparations in vitro.


A first report of the genus Culiseta Felt in Malaysia (Diptera: Culicidae).


Effect of thyroid hormones on metabolism. 3. Effect of thyroxine and thyroidectomy on adrenal gland enzyme activities.


Additional aspects of passivity and feminine identification in the male.


Modification by 8-azaguanine of the effects of hydrocortisone on the induction and inactivation of tyrosine transaminase of rat liver.


Molecular sieve studies of interacting protein systems. IV. Molecular size of the D-amino acid oxidase apoenzyme subunit.


Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri.


Brain catecholamines and the reserpine-induced stimulation of the pituitary-adrenal system.


Studies on the catalytic and regulatory properties of homoserine dehydrogenase of Zea mays roots.


Partial purification of a NADPH-dependent 21-hydroxysteroid dehydrogenase from human placenta.


Glutamate dehydrogenase in Nitrosomon as europaea and the effect of hydroxylamine, oximes and related compounds on its activity.


Microsomal electron transfer system of bovine retinal pigment epithelium.


Residual anticaries effect of repeated topical sodium fluoride applications by mouthpieces.


The effect of light and light deprivation upon the ultrastructure of the larval mosquito eye. 3. Multivesicular bodies and protein uptake.


Relative activity of prostaglandins E1, A1, E2 and A2 on lipolysis, platelet aggregation, smooth muscle and the cardiovascular system.


The effects of osmotic pressure on procaine-induced vacuolation in cell culture.


Relation of brain sensitivity and hepatic metabolism of hexobarbitone to dose-response relations in infant and young rats.


Setaria cervi, a test organism for screening antifilarial agents.


Protection against semicarbazide-induced convulsions in mice at a hypobaric pressure.


On the locus of the airway constricting effect of histamine in the dog.


Jejunal ulcers produced by indomethacin.


Effect of subcutaneously administered degraded carrageenan on the production of histamine-induced gastric and duodenal ulceration.


Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion.


A method for the measurement of therapeutic levels of (+)-amphetamine in human plasma.


Serosal transfer of glucose during peristalsis.


D A/Hersey JA, Barzily RB: Dissolution rates of sparingly soluble tablets.


Solubilization and rheology of the system ascorbic acid-water-polysorbate 80: temperature effects.


A comparison of the effects on blood glucose and ketone-body levels, and of the toxicities, of pent-4-enoic acid and four simple fatty acids.


The preferred conformation of noradrenaline and a consideration of alpha-adrenergic receptor.


Studies on the structure and function of the mammalian testis. II. Cytological and histochemical observations on the testis of the rat after a single exposure to heat applied for different lengths of time.


An electron microscopic study of the early changes proximal to a constriction in sympathetic nerves.


An electron microscopic study of the early changes distal to a constriction in sympathetic nerves.


The alcoholic fermentation of glucose by Moniliformis dubius (Acanthocephala), in vitro.


Suppression of spontaneous spike generation by catecholamines in the smooth muscle of the guinea-pig taenia coli.


Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli.


Electron microscopy of synaptic glomeruli in the thalamic relay nuclei of the cat.


An electron microscopic study of the mode of termination of cortico-thalamic fibres within the sensory relay nuclei of the thalamus.


Increase of membrane conductance by adrenaline in the smooth muscle of guinea-pig taenia coli.


A carbon-phosphorus bond in nature.

A carbon-phosphorus bond in nature.


An evaluation of the adrenergic receptor types in isolated segments of the small intestine of the rabbit.


The effect of NADPH on steroidogenesis by the human adrenal gland in vivo.


Adrenal steroid therapy in neurological disease. Part I.


The pulmonary pressor response to hypoxia in isolated perfused lungs of cats: the influence of mepyramine maleate and semicarbazide.


Aldohexuronic acid catabolism by a soil Aeromonas. Bacteria which utilize mannuronic acid as an energy source were isolated from nature. One of the organisms, identified as a member of the genus Aeromonas, used glucuronate, galacturonate, and mannuronate as the sole source of carbon and energy. Glucuronate- and galacturonate-grown resting cells oxidized both glucuronate and galacturonate rapidly, but mannuronate slowly. Mannuronate-grown cells oxidized all three rapidly, with the rate of mannuronate utilization somewhat lower. Cell-free extracts from glucuronate-, galacturonate-, and mannuronate-grown Aeromonas C11-2B contained glucuronate and galacturonate isomerases, fructuronate, tagaturonate, and mannuronate reductases, and mannonate and altronate dehydratases, with the exception of glucuronate-grown cells which lacked altronate dehydratase. Thus, the pathway for glucuronate and galacturonate catabolism for Aeromonas was identical to Escherichia coli. Glucuronate and galacturonate were isomerized to d-fructuronate and d-tagaturonate which were then reduced by reduced nicotinamide adenine dinucleotide to d-mannonate and d-altronate, respectively. The hexonic acids were dehydrated to 2-keto-3-deoxy gluconate which was phosphorylated by adenosine triphosphate to 2-keto-3-deoxy-6-phospho gluconate. The latter was then cleaved to pyruvate and glyceraldehyde-3-phosphate. Mannuronate was reduced directly to d-mannonate by a reduced nicotinamide adenine dinucleotide phosphate-linked oxidoreductase. d-Mannonate was then further broken down as in the glucuronate pathway. The mannuronate reducing enzyme, for which the name d-mannonate:nicotinamide adenine dinucleotide (phosphate) oxidoreductase (d-mannuronate-forming) was proposed, was shown to be distinct from altronate and mannoate oxidoreductases. This is the first report of a bacterial oxidoreductase which reduces an aldohexuronic acid to a hexonic acid. The enzyme should prove to be a useful analytical tool for determining mannuronate in the presence of other uronic acids.


CVaccines. Wellcome supplies frozen.

CVaccines. Wellcome supplies frozen.


Comparison of methoxyflurane and parenteral agents for obstetric analgesia.


Inhibition of hypostome formation and polarity re-versal in Hydra.


A research report on the anti-fatigue effects of magnesium pemoline.


Oxygen and the micro-aerophilic bacteria: growth and peroxidase activity of Lactobacillus casei.


Kukukuku: medical patrol into one of the last restricted areas in the New Guinea highlands.


9th AMA Air Pollution Medical Research Conference. Synthesis, perspective, and future applications.


Human glucose 6-phosphate dehydrogenase: purification and characterization of Negro type variant (A+) and comparison with normal enzyme (B+).


The management of acute allergic reactions in general practice.


Evidence for muscarinic receptors in the adrenal medulla of the dog. 1. The release of catecholamines from the adrenal medulla by the cholinergic drugs was monitored by the perfusion pressure rise in autoperfused and sympathetically denervated hindlimbs of the dog.2. Acetylcholine, dimethylphenylpiperazinium (DMPP) and methacholine, given in relatively small doses into the aorta proximal to the blood supply to the adrenal glands, caused a marked rise in perfusion pressure which was due to the release of catecholamines from the adrenal medulla.3. Atropine (1 mg/kg intravenously) blocked the pressor response to methacholine only. The ganglion-blocking agents (mecamylamine 4-5 mg/kg or hexamethonium 10 mg/kg) given subsequently blocked the pressor responses to the other two cholinergic drugs. The ganglion-blocking agents, when given before atropine, blocked the pressor action only of DMPP. These agents partly depressed, rather than potentiated, the pressor response to methacholine.4. The results suggest that muscarinic as well as nicotinic receptors are present in the adrenal medulla of the dog.5. Neither atropine nor ganglion-blocking drugs alone reduced the pressor response to acetylcholine. It is postulated that the blockade of one set of receptors makes more acetylcholine available for the other set of receptors and so inactivation of the former receptors are compensated by the increased release through the activation of the latter's.


Inhibition by cinnarizine and chlorpromazine of the contraction induced by calcium and adrenaline in vascular smooth muscle.


Taloximine, a new respiratory stimulant with brochodilator properties. 1. A novel phthalazine analogue taloximine (1-hydroxyimino-4(2-dimethyl-aminoethoxy)-1,2-dihydrophthalazine monohydrochloride monohydrate) stimulated respiration in conscious rabbits at doses of 7 mg/kg and above.2. Taloximine antagonized the depressant action of morphine on respiration in rabbits at doses of 10 mg/kg. At high doses it resuscitated rabbits after they had been given lethal doses of sodium pentobarbitone.3. In in vitro preparations of the trachea or bronchus taloximine was about equiactive with aminophylline. In the Konzett-Rössler preparation the intravenous ED50 for taloximine was about 18% of that of aminophylline, whereas after oral administration the two drugs were equiactive.4. Taloximine, unlike aminophylline, did not protect guinea-pigs against anaphylactic microshock to egg albumen.5. Taloximine shortened the duration of the loss of righting reflex in mice due to hexobarbitone more effectively than bemegride, nikethamide or vanillic acid diethylamide.6. In the dose required to stimulate respiration taloximine had only slight cardiovascular effects. Up to four times this dose produced no evidence of general excitation of the central nervous system.


Analgesic activity after intracerebral injection in the mouse.


The release and fate of vaso-active hormones in the circulation.


A measles vaccine withdrawn.

A measles vaccine withdrawn.


Solubilities of testosterone propionate in non-polar solvents at 100 degrees.


Polyarteritis nodosa.

Polyarteritis nodosa.


The effect of pH and sodium metabisulphite on the stability of physostigmine sulphate solutions to heat and ionizing radiation.


The isolated expansor secundariorum--a smooth muscle preparation from the wing of the domestic fowl.


The effect of alloxan diabetes upon adjuvant-induced arthritis in the rat.


Effect of pretreatment with monoamine oxidase inhibitors or (+)-amphetamine on leptazol convulsions in mice and rats.


An adrenergic neuron blocking action of propranolol in isolated tissues.


Micro-colorimetric determination of adenosinetriphosphatase activity in freeze-dried sections of rat diaphragm muscle.


The metabolism of 16 alpha-ethylprogesterone by rat liver in vitro.


The uptake of cetyltrimethylammonium bromide by Escherichia coli.


Protein-binding of small molecules: new gel filtration method.


Some limitations of continuous shear methods for the study of pharmaceutical semi-solids.


Thixotropy and rheopexy of propyliodone suspensions in arachis oil: effect of median particle size.


Energy utilization in a fluid energy mill.


A modified pressure wheel for the instrumentation of rotary tabletting machines.


Binding of crystal violet by nucleic acids of Escherichia coli.


The mixing of powders flowing down an inclined plane.


The use of diffusion theory for the assessment of mixing in a rotary coating pan.


The bactericidal effect of silver ions on Pseudomonas aeruginosa.


Coagulation and flocculation in suspensions of griseofulvin and polystyrene latex.


The anti-acetylcholinesterase activities of the alkaloids of Physostigma venenosum seeds.


The dissolution of paracetamol tablets and the in vitro transfer of paracetamol with and without sorbitol.


Synthesis and pharmacological action of some N-alkyl morpholines and their salts.


Dissolution rate measurement by an automated dialysis method.


The influence of alkyl substitution in acids on their performance in the buccal absorption test.


Some observations on the use of absorbance measurements in bacteriology.


Water-in-oil solubilized vaccine adjuvants.


The effect of acetylsalicylic acid, phenylbutazone and indomethacin on the binding of 11-hydroxysteroids to plasma proteins in patients with rheumatoid arthritis.


An impurity in polyethylene glycol 300.

An impurity in polyethylene glycol 300.


The cathode ray polarography of phenylmercuric nitrate.


The anomalous chromatographic behaviour of dichlorophen and p-chlorophenol.


The polarography of cephalosporin C derivatives.


Routine detection and identification in urine of stimulants, analgesics, antihistamines, local anaesthetics and other drugs, some of which may be used to modify performance in sport.


The effect of a non-ionic surfactant upon the antifungal activity of benzoic acid.


Pharmaceutical applications of vapour-controlled thin-layer chromatography.


The determination of diamorphine by thin-layer chromatography and spectrophotometry.


Examination of fennel fruits by gas chromatography without preliminary distillation.


Isothermal diffusion measurement on the system water-sodium salicylate-sodium chloride at 25 degrees at one composition.


Gas-liquid chromatography of heteroyohimbine alkaloids: the effect of methoxy substitution and of configuration.


The crystallization of aspirin from ethanol.


Cell size changes during the growth of Escherichia coli partially inhibited by some antibacterial agents.


The preparation and properties of (+)- and (--)-guanoxan.


The extraction of azovan blue from precipitated plasma proteins.


Inhibition of glutamate decarboxylase by salicylate in vitro.


The kinetic behaviour of cardiac glycosides in vivo, measured by isotope techniques.


Biological half-lives of [4-14C]testosterone and some of its esters after injection into the rat.


Effects of nicotine on motor co-ordination and spontaneous activity in mice.


The dissolution of commercial aspirin.

The dissolution of commercial aspirin.


An improved cannula suitable for chronic implantation into a lateral cerebral ventricle of the rat.


Effect of chelating agents on copper content and tyramine response of the rat heart.


The mechanism of action of 2-halogenoethylamines at the adrenergic alpha-receptor and a further investigation of the "spare receptor" hypothesis.


5-Hydroxyindole compounds in the perfusates from frog head.


Bradykinin antagonism by dimethothiazine.


The transport and life-span of amine storage granules in bulbospinal noradrenaline neurons of the rat.


Effect of gastrin I and caerulein on gastric acid secretion in rats.


Noradrenaline turnover in renal hypertensive rats.


On the mechanism of lipomobilizing effect of chlordiazepoxide.


Examination of the hallucinogen 2,5-dimethoxy-4-methylamphetamine.


Enhancement of the convulsant action of thiosemicarbazide in mice.


Relative activities of NAD- and NADP- isocritric dehydrogenases in bean mitochondria modified by glycerol or NADP. Mitochondria from cotyledons of Vigna sesquipedalis (L.) Fruwirth (starchy seed) showed no NAD-isocitric dehydrogenase (NAD-IDH) activity by the methods which have been known to be useful for the detection of NAD-IDH in mitochondria of plants including castor bean and alaska pea. When the Vigna cotyledon mitochondria were treated with glycerol, NAD-IDH activity appeared and NADP-isocitric dehydrogenase (NADP-IDH) activity was inhibited. The inhibition of mitochondrial NADP-IDH by glycerol was overcome by the addition of excess NADP. On the other hand, NADP-IDH activity in the soluble fraction of cell components was only slightly inhibited by glycerol and no NAD-IDH activity was elicited. It was postulated that NADP-IDH in mitochondria is converted to NAD-IDH by glycerol and back to NADP-IDH with NADP by the alteration in the spatial configuration of the enzyme. However, there could be 2 proteins as the other possibility. The NADP-IDH in the soluble fraction which is not subject to such alteration is different from the mitochondrial NADP-IDH.


Pills for everything.

Pills for everything.


Recent advances in neuropharmacology of neurological interest.


Interactions of polynucleotides and their components. II. Interaction of uracil derivatives with alkali- and alkali earth chlorides.


Kinetics of the hydrolysis of phosphatidylcholine and lysophosphatidylcholine.


Esters of choline and beta-trimethylammoniopropionic acid: geometrical isomerism and anti-acetylcholinesterase activity.


Metabolism and excretion of promazine by the horse.


Buccal absorption and other properties of pharmacokinetic importance of imipramine and its metabolites.


The corticotrophic activity of tetracosactide in the adrenal ascorbic acid depletion test.


Effect of Coprinus atramentarius on the metabolism of ethanol in mice.


Anticholinergic effects and passage through the intestinal wall of N-butylhyoscine bromide.


Competitive antagonism of isoprenaline-induced cardiac necroses by beta-adrenoreceptor blocking agents.


Detection of drugs with peripheral vascular effects similar to those of nicotinic acid.


Inhibition by phenobarbitone of oestrogen-stimulated increases in uterine enzymes.


Effect of actinomycin D on the recovery of cardiac noradrenaline after depletion with guanethidine.


The presence of dopamine in cat spleen and blood.


The effect of diet in West Africa on the pH of human urine.


Corticosteroid modification of guinea-pig anaphylaxis.


Removal of plasma metyrapone in rats submitted to previous pharmacological treatment.


Proteolytic activity, its inhibitors, and the blastic reaction in graft rejection.


New halocyclopropane insecticides and the mode of action of DDT.


On the degranulation of mesenteric mast cells caused by antihistamine in albino rats. Effects of various dosages of antihistamine.


Correlation between field formation, proton translocation, and the light reactions in photosynthesis.


Correlation between plastoquinone reduction, field formation and proton translocation in photosynthesis.


The effect of 2,4-dinitrophenol on adipose-tissue metabolism. 1. The effect of dinitrophenol on the metabolism of glucose labelled with (14)C and tritium by epididymal fat-pad segments from fed rats was studied. Dinitrophenol at concentrations of 0.1-0.3mm: (a) had little effect on glucose utilization; (b) depressed synthesis of fatty acids and greatly increased that of lactate; (c) increased the T/(14)C ratio in fatty acids synthesized from [U-(14)C,3-T]glucose and decreased that in fatty acids synthesized from [U-(14)C,4-T]glucose; (d) abolished randomization of (14)C from [6-(14)C]glucose in lactate. 2. Dinitrophenol stimulated oxidation of pyruvate and greatly inhibited the oxidation of lactate. It inhibited lipogenesis from pyruvate and lactate. 3. From the isotope data it was calculated that: (a) dinitrophenol stimulates oxidation via the tricarboxylic acid cycle three- to six-fold; (b) dinitrophenol depresses markedly the operation of the pentose cycle; (c) in the presence of dinitrophenol, NADPH formed in the pentose cycle provides all the hydrogen equivalents for fatty acid reduction, whereas, in its absence, NADPH provides 50-70% of the hydrogen equivalents; (d) in the presence of dinitrophenol, there is an excess of ATP produced in the cytoplasm, which flows into the mitochondria. A reverse flow operates in the absence of dinitrophenol. 4. A balance of formation and utilization of reduced nicotinamide nucleotides in the cytoplasm was established. With dinitrophenol there is some excess of NADH. There are indications that this excess may be transferred into mitochondria in the form of malate. 5. Our results are interpreted to indicate the absence from adipose tissue of the alpha-glycerophosphate shuttle for transferring reducing equivalents from the cytoplasm to mitochondria. 6. The effects of dinitrophenol are accounted for in terms of decreased ATP concentrations in the cells, leading to marked decrease in pyruvate carboxylation in the mitochondria and depression of fatty acid synthesis in the cytoplasm.


Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. Lanosterol was biosynthesized in pig liver homogenate from [4,8,12-(14)C(3)]farnesyl pyrophosphate and [4S-4-(3)H]NADPH through the intermediary formation of squalene labelled asymmetrically with (3)H. The biosynthetic lanosterol, freed from labelled 24,25-dihydrolanosterol, which was also synthesized, was converted into 24,25-dihydrolanosteryl acetate and subjected to chemical degradations to locate the position(s) of the (3)H label in the molecule. The ratio of (3)H at C-11 to that at C-12 was found to be 1.28. Although a certain inequality of labelling was thus indicated, experimental uncertainties did not permit the conclusion that the asymmetrically labelled squalene might have been cyclized preferentially from one end.


The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. 1. Changes in liver glutathione reductase and glutathione peroxidase activities in relation to age and sex of rats were measured. Oxidation of GSH was correlated with glutathione peroxidase activity. 2. Glutathione reductase activity in foetal rat liver was about 65% of the adult value. It increased to a value slightly higher than the adult one at about 2-3 days, decreased until about 16 days and then rose after weaning to a maximum at about 31 days, finally reaching adult values at about 45 days old. 3. Weaning rats on to an artificial rat-milk diet prevented the rise in glutathione reductase activity associated with weaning on to the usual diet high in carbohydrate. 4. In male rats glutathione peroxidase activity in the liver increased steadily up to adult values. There were no differences between male and female rats until sexual maturity, when, in females, the activity increased abruptly to an adult value that was about 80% higher than that in males. 5. The rate of GSH oxidation in rat liver homogenates increased steadily from 3 days until maturity, when the rate of oxidation was about 50% higher in female than in male liver. 6. In the liver a positive correlation between glutathione peroxidase activity and GSH oxidation was found. 7. It is suggested that the coupled oxidation-reduction through glutathione reductase and glutathione peroxidase is important for determining the redox state of glutathione and of NADP, and also for controlling the degradation of hydroperoxides. 8. Changes in glutathione reductase and glutathione peroxidase activities are discussed in relation to the redox state of glutathione and NADP and to their effects on the concentration of free CoA in rat liver and its possible action on ketogenesis and lipogenesis.


The type-specific substance from Pneumococcus type 29. 1. A pentasaccharide, corresponding to the dephosphorylated repeating unit of the specific substance, S.29, from Pneumococcus type 29, was obtained by hydrolysis with alkali followed by enzymic dephosphorylation. 2. The pentasaccharide was shown to be O-2-acetamido-2-deoxy-beta-d-galactopyranosyl-(1-->6)-O-beta-d-galactofuranosyl-(1-->3)-O-beta-d-galactopyranosyl-(1-->6)-O-beta-d-galactofuranosyl-(1-->1)-ribitol. 3. The phosphodiester linkages in S.29 join the hydroxyl group at position 5 of ribitol and the hydroxyl group at position 3 or 4 of a 2-acetamido-2-deoxy-d-galactose residue in the next repeating unit. 4. A partial structure for S.29 was deduced from these experiments.


Oxidative phosphorylation in an extract of Anabaena variabilis.


Abnormalities of the upper urinary tract in cryptorchidism.


Metabolism of leucine in protein-calorie-deficient rats. 1. Protein-calorie-depleted rats exhibit a decreased ability to oxidize leucine as compared with control animals. 2. The block in degradation of l-leucine is due to decreased activities of l-leucine transaminase and d-amino acid oxidase associated with liver mitochondria. 3. Cytoplasmic l-leucine transaminase in liver is not affected by the protein depletion. 4. The specific activities of the mitochondrial enzymes can be increased by a single oral dose of 1g. of Bacto-Peptone (meat hydrolysate). The effect of Bacto-Peptone can be inhibited by prior administration of dosages of 10mg. of puromycin/100g. body wt., suggesting that the increased enzyme specific activities may be due to new synthesis of enzyme protein.


Seminoma in undescended testes.

Seminoma in undescended testes.


Transverse ectopia of the testis.

Transverse ectopia of the testis.


Combined drug treatment of newly hospitalized, acutely ill psychiatric patients.


A study of variation and progression in oncongenicity in an SV 40-transformed hamster heart cell line and its clones.


The anatomy and physiology of the posterior stomach nerve (p.s.n.) in some decapod crustacea.


Host antigens in schistosomiasis.

Host antigens in schistosomiasis.


Protective action of various drugs on provocation tests with respiratory irritants in patients with chronic non-specific lung disease (CNSLD).


Capabilities and limitations of major drug groups in allergy: their role within current theories.


Effects of pipradrol hydrochloride on geriatric patients.


Studies on the mechanism of sex difference in drug-oxidizing activity of liver microsomes.


Metabolism of drugs in old rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of old rats.


Failure of cycloheximide to induce tyrosine transaminase in the anesthetized rat. It was recently reported that cycloheximide, an inhibitor of protein synthesis, induces tyrosine transaminase in the liver of adrenalectomized rats. We have been unable to confirm this effect in the anesthetized animal and our data show that cycloheximide inhibits the induction caused by hydrocortisone in adrenalectomized rats or by stress in intact rats.


Effect of neurohumors on spinal vasomotor neurons.


Tyrosine enteroreceptor of Hydra: its function in eliciting a behavior modification. Hydra that still contain partially digested food in their gastrovascular cavities, undergo a modified feeding response when they ingest additional prey. A localized constriction is formed just below the sites of tentacle attachment, preventing the loss of gastrovascular contents. This response involves the interaction of an ectodermal receptor system for glutathione and an endodermal receptor system for tyrosine.


Hexokinase isozymes in human erythrocytes.


Hereditary hemolytic anemia due to glucose-6-phosphate dehydrogenase Torrance: a new variant.


Antibiotic production by new form-genera of the Actinomycetales. I. Sporangiomycin, an antibacterial agent isolated from Planomonospora parontospora var. antibiotica var. nov.


Correspondence: the mentally handicapped.


Study of man during a 56-day exposure to an oxygen-helium atmosphere at 258 mm. hg total pressure. XIV. Communications.


Attempted suicide: facts and theories.

Attempted suicide: facts and theories.


Comparative studies on the influence of different anti-arrhythmic drugs on the alpha- and beta-receptors in cat blood pressure test.


The exhaustion of adaptive reserve and depression.


Hospitalized alcoholic patients. I. A two-year study of medical, social, and psychological characteristics.


Synaptic transmission in the central nervous system and its relevance for drug action.


The use of LSD and ditran in the treatment of therapy resistant schizophrenics (symptom provocation approach).


The influence of the water fluoridation on the surface enamel.


NADP-linked 17-beta- and 20-alpha-steroid reductase activity in the rabbit uterus.


The effect of progesterone, glucose-6-phosphate dehydrogenase, adrenocorticotrophic hormone and metyrapone on adrenocortical secretion of rat adrenal glands cultured under hyperbaric oxygen.


The allergist and the eosinophil.

The allergist and the eosinophil.


The management of allergic disorders in children. A long-term program based on immunologic and nonimmunologic principles.


The effect of hyperbaric oxygen on delta-5-3-beta-hydroxysteroid dehydrogenase, 11- and 18-steroid hydroxylases, and on nicotinamide-adenine dinucleotide phosphate-linked dehydrogenases in organ cultures of rat adrenal glands.


Adrenergic control of cochlear blood flow.


Mosquito collections in a high rainfall area of North Queensland, 1963-1964.


A psychiatric study of patients with regional enteritis.


Effect of sulfate and phosphate esters of estrogens on the level of aminotransferases in the perfused rat heart.


N-demethylation of the chemosterilant HEMPA by ouse fly microscomes.


Glucose dehydrogenase of Bacillus megaterium KM. Coupling of the cytoplasmic enzyme with membrane-bound cytochromes.


Stabilization of oil-in-water emulsions by non-ionic detergents: properties of synthetic detergents at anisole- and chlorobenzene-water surface.


King Edward's Hospital Fund for London: the Hospital Centre.


Transmitters and antagonists.

Transmitters and antagonists.


Adrenergic receptors in the guinea-pig trachea.


Effects of transection on the intestinal slow-wave frequency gradient.


Comparison of enzymes of twelve species of mosquitoes.


Toxicity and effects on motor coordination of some neurotropic drugs on the cockroach nauphoeta cinerea.


Metabolism of alpha-glyceryl ethers by Tetrahymena pyriformis. II. Properties of a cleavage system in vitro.


Assay and substrate specificity of liver 11 beta-hydroxysteroid dehydrogenase.


Lack of inter-action between propranolol and mebanazine.


The role of calcium in neurohumoral and neurohormonal extrusion processes.


Mutal suppression of cardiovascular effects of some beta-adrenoreceptor agonists in the cat.


A psychological study of survivors and nonsurvivors of myocardial infarction.


The effect of some non-ionic surfactants and a polyoxyethylene glycol on the dissolution rate of griseofulvin.


The optical rotatory dispersion of some N-decyl-N-N-dimethylalanine salts and their critical micelle concentrations.


Aspirin and mucus.

Aspirin and mucus.


Distribution and metabolism of dopamine in guinea-pigs.


A new approach to the use of histamine skin tests in the study of antihistamine drugs.


Adrenergic effector mechanisms in the stomach of the sheep.


Aggressive bahviour provoked by pargyline in rats pretreated with diethyldithiocarbamate.


Failure of morphine dependence in rats to influence brain noradrenaline turnover.


An apparatus for the study of intestinal transfer of drugs.


Brain desipramine level in relation to the anti-reserpine acitivity of imipramine.


On the mode of action of some immunosuppressant drugs.


The continuous recording of arterial blood pressure in the conscious unrestrained rat.


Structural requirement for antitussive activity in some novel 16-substituted derivatives of 6,14-endoethenotetrahydrothebaine.


The effect of methylcellulose on the absorption of nitrofurantoin from the gastrointestinal tract.


Effect of protriptyline on the formation of (3H)noradrenaline from (3H)dopa.


Uptake of (3H)noradrenaline in the rat heart during increased sympathetic nervous activity associated with cold.


Effect of some psychotropic drugs on mice from a spontaneously aggressive strain.


The isolation of L-leucine-free hypoglycin-A.


In vitro demonstration of adrenergic receptors controlling melanophore responses of the lizard, Anolis carolinensis.


Emergency treatment of heart-rate disturbances and pulmonary oedema.


The efficacy of managing postanaesthetic respiratory depression with analeptics.


Electroencephalographic effect of doxapram hydrochloride in humans.


The search for a pharmacologic ventilator.


Controlled hypotension effected by sodium nitroprusside.


Glucose 6-phosphate dehydrogenase and hexose 6-phosphate dehydrogenase of mammalian tissues.


On the stimulation of ornithine decarboxylase and RNA polymerase activity in rat liver after treatment with growth hormone.


Proprietary hallucinogens.

Proprietary hallucinogens.


Intracellular location and genetic control of isozymes of NADP-dependent  isocitrate dehydrogenase and malate dehydrogenase.


The delta-5-3-beta-hydroxysteroid dehydrogenase of rat ovarian tissue. The effect of adenosine 3',5'-cyclic-monophosphoric acid.


The pharmacology of parkinsonism (a review).


Prediction of job success for hospital aides and orderlies from MMPI scores and personal history data.


What pathological dimensions lie beyond the normal dimensions of the 16 PF? A comparison of MMPI and 16 PF factor domains.


An electron microscopic study of the liver of endotoxin-shocked dogs treated with a combination of propiomazine and levarterenol.


Psychological assessment methods.

Psychological assessment methods.


Shock treatment.

Shock treatment.


Performance errors on Ravens progressive matrices (1938) by sociopathic and schizotypic personality types.


Masculinity-femininity orientation on the MMPI and marital status.


Incidence of dental disease among the Navajo Indians of Monument Valley, Utah.


Deuterium solvent isotope effects in reactions catalyzed.


Number of transformable units per cell in Diplococcus pneumoniae. Analysis of frequencies of single and random multiple transformations in Diplococcus pneumoniae showed that there are at least two transformable units per cell of the total population in highly competent cultures. If 100% of the cells are competent in these cases, the units may be interpreted as the strands of one duplex deoxyribonucleic acid recipient chromosome. The theory is developed to allow for extension to more complex situations.


Escherichia coli mutant with elevated nicotinamide adenine dinucleotide phosphate (reduced) oxidase activity. A slow-growing mutant of Escherichia coli with greatly elevated nicotinamide adenine dinucleotide phosphate (reduced; NADPH) oxidase activity has been isolated. The oxidase activity of the wild-type organism, normally low at pH 7.5, was increased when the assay was performed at pH 6.0. Sucrose density gradients of sonic extracts of the mutant and wild-type strains revealed several peaks of NADPH oxidase activity at pH 6.0. The parent organism had a peak of activity of high molecular weight which was absent from the mutant. The mutant strain had an activator capable of increasing the activity of all wild-type density gradient peaks, especially the one of high molecular weight. The activator was either missing or masked in the wild type. Agar gel electrophoresis of the extracts uncovered a rapidly moving band from the wild type, missing from the mutant; the material in this band had weak NADPH-diaphorase activity and strongly inhibited the activity of the mutant NADPH oxidase. It was concluded that, in wild-type E. coli, NADPH oxidase activity is regulated by a proper balance of an activator and an inhibitor. The absence of the inhibitor, as in the mutant, or the inactivation of the inhibitor at acid pH levels, results in a high level of NADPH oxidase activity. The relation of high NADPH oxidase levels and subsequent decrease of the NADPH pool to the decrease in growth rate is considered.


Characterization of excess deoxyribonucleic acid synthesized by pneumococci in the presence of polyadenylic acid and deoxyribonucleic acid precursors. Excess deoxyribonucleic acid (DNA) synthesized by cell suspensions of encapsulated pneumococci in the presence of polyadenylic acid plus all eight of the naturally occurring deoxyribonucleosides and deoxyribonucleotides has been characterized in several ways. The DNA represents complete molecules, is synthesized by a relatively large population at a steady rate, and is replicated in a semiconservative manner.


Demonstration of a bactericidal substance against beta-hemolytic streptococci in supernatant fluids of staphylococcal cultures. Staphylococcal skin isolates belonging to phage type 71 were found to produce a bactericidal substance against some streptococci, pneumococci, and corynebacteria. Fifteen strains of group A streptococci belonging to 13 different M types, group C streptococci, and group D streptococci were uniformly inhibited on solid media and in broth by membrane-filtered supernatant fluids of the staphylococcal broth cultures. Inhibition of group G streptococci and other staphyloccoci was variable, and no inhibition of group B streptococci or of a variety of gram-negative rods was demonstrable. A quantitative variation observed to exist among susceptible organisms was a function of the inoculum size of the inhibited strains. The bactericidal substance could be detected best from 24 to 48 hr after inoculation of the staphylococci in tryptic soy broth or in a dialysate of tryptic soy broth. Little or no bactericidal activity was noted when the organisms were grown in several other liquid media. The bactericidal substance was nondialyzable and could be precipitated with ammonium sulfate. It was heat-stable and its activity was not altered within a pH range of 4.0 to 8.5. Pronase and three times crystallized trypsin totally abolished its activity. The concentrated ammonium sulfate precipitate could be fractionated on a Sephadex G-100 column into several peaks, with the bactericidal activity localized to a single peak.


Inhibition of pacemaker systems in the hydroid Tubularia.


Neuromuscular properties of mesenteries from the sea-anemone metridium.


Genetics society of Canada symposium. II. On methodology in genetics research. Winnipeg, Manitoba, May 17, 1968. Methodology in human genetics.


Purification and characterization of genetic variants of 6-phosphogluconate dehydrogenase.


A study of the biological activity of toxic material derived from nematocysts of the cubomedusan Chironex flecki.


Bacterial resistance to antimicrobials.

Bacterial resistance to antimicrobials.


Iron deficiency anemia and hepatic lesions in weanling rats.


A gauntlet to the med schools.

A gauntlet to the med schools.


Convulsive disorders in infants and children.


The telephone and the practice of medicine.


Illinois Department of Public Aid payment procedures and policies explained. V. Of a series.


Surgical grand rounds. Non-parasitic cyst of the liver.


Liquid butaperazine in the treatment of chronic psychosis in a mental health clinic.


Medical-legal problems of Illinois physicians. Medical Practice Act.


The historical background of the gridiron or muscle-splitting incision for appendectomy.


Abortion--a Catholic view.

Abortion--a Catholic view.


Psychotherapy applied to comprehensive medical practice.


Pharmacologic evaluation of a new series of cholinergic antagonists containing an agonist moiety.


Antihistamines.

Antihistamines.


Methodological implications of content-acquiescence correlation in the MMPI.


Microorganisms on Mars.

Microorganisms on Mars.


Antihistamines in otolaryngology.

Antihistamines in otolaryngology.


Altered response to pneumococcal polysaccharide in offspring of immunologically paralyzed mice. The dose of pneumococcal polysaccharide type III required to induce immunologic paralysis in newborn offspring of immunologically paralyzed mice was one-tenth of the corresponding paralyzing dose for newborn offspring of normal mice. Similarly, immunization of the offsprinig of the paralyzed mice was accomplished with one-tenth the dose of polysaccharide necessary to immunize normal newborn mice. The altered susceptibility of newborn mice from paralyzed mothers to the induction of both paralysis and immunity was predicted from theories of antibody formation which postulate that the induction of tolerance or immunity is controlled by the concentration of natural antibodies specific for the antigen used.


The mechanism of action of adrenocorticotropic hormone.


Restoration of glycolysis and respiration in Ehrlich ascites tumor cells inhibited by 2,2'-dithiodipyridine.


Antagonistic effects of three dichlorophenylethanolamines (dichloronoradrenaline, dichloroadrenaline and dichloroisoproterenol) on isoproterenol-induced free fatty acid mobilization.


Enhanced glucuronide formation in different tissues following drug administration.


Table-salt fluoridation in Hungary.

Table-salt fluoridation in Hungary.


The metabolism and distribution of penoline in rat brain.


Comparison of speech materials recorded in room air at ground level and in a helium-oxygen mixture at a simulated altitude of 18,000 feet.


Caries prevalence and caries intensity among 12,344 schoolchildren of French Polynesia.


Experimental study of a passive thermal control system for space suits.


Prevalence of dental caries and periodontal disease in military personnel.


Scrotal abnormalities in rams in tropical Queensland with particular reference to ovine brucellosis and its control.


The cariostatic effect of calcium sucrose phosphate in a group of children aged 5-17 years. IV.


Nuclear and microsomal nicotinamide-adenine dinucleotidases of rat liver.


Religion and attempted suicide.

Religion and attempted suicide.


Effect of pH, temperature, osmolarity and drugs on 5-hydroxytryptamine content and light and electron microscopic structure of rat mast cells in vitro.


Cryptorchidism with ectopic internal inguinal ring.


Influence of transcortin and albumin on the rate of reduction of progesterone on human placental 20-alpha-hydroxysteroid dehydrogenase.


Intra-arterial fluorescein in the evaluation of a vasodilator drug.


Effects of alpha and beta adrenergic blockade on the capability of the heart after myocardial infarction.


Microsomal enzymes in porcine lens.

Microsomal enzymes in porcine lens.


Recent developments in lincomycin research.


Effect of pre- and post-irradiation administration of magnesium pemoline on radioresistance.


Preliminary clinical report of the medical aspects of Apollos VII and 8.


Regenerable carbon dioxide sorbents.

Regenerable carbon dioxide sorbents.


Drug treatment of the out-patient asthmatic (chronic asthmatic).


Mechanism of conversion of the purple intermediate into the fully reduced form of D-amino-acid oxidase.


Observations on dengue fever, benign protector and killer: a Dr. Jekyll and Mr. Hyde.


NADP-specific malate dehydrogenase and glycerate kinase in leaves and evidence for their location in chloroplasts.


Charge transfer and excitation energy transfer between reduced and oxidized pyridine nucleotides.


Decrease of rated adjustment on repeat DAP tests apparently due to lower motivation.


Oxidation of reduced flavins by quinones.


Studies on nitro-reducing systems of rat liver.


Glycine in the spinal cord of cats with local tetanus rigidity. In cats, significant loss of glycine occurred in spinal grey matter on the side of local tetanus, whereas the gamma-aminobutyric acid concentration remained unaltered. These findings suggest that tetanus rigidity is due to the blocking of the spinal inhibitory transmission by decrease of inhibitory transmitter and that glycine is an effective inhibitory transmitter in cat spinal cord.


Tetracycline-resistant pneumococcal infection. Incidence, clinical presentation, and laboratory evaluation.


Membrane adenosine triphosphatase activity of vascular smooth muscle.


Structure--activity and metabolism studies on organophosphate teratogens and their alleviating agents in developing hen eggs with special emphasis on Bidrin.


Seizure threshold and hexafluorodiethyl ether in brain tissue.


Drug reactions. V. Cutaneous reactions to anticoagulants.


Evaluation of a new treatment paradigm for phobias.


The loss of antigen(or hapten)-binding activity of Fab fragments of antibodies after irradiation by monochromatic ultraviolet light at 289 nm.


Engulfment and bactericidal capabilities of peripheral blood leukocytes in chronic leukemias.


Human liver aldehyde dehydrogenase: partial purification and properties.


The enzyme histochemistry of gastric carcinoma in man.


Influence of temperature on the composition of fatty acids and on lipogenesis in frog tissues.


pH profile of a peptide receptor.

pH profile of a peptide receptor.


New dimensions in the treatment of alcoholism.


New alcoholism treatment program.

New alcoholism treatment program.


The view box.

The view box.


Blood lipoproteins may be key to understanding atherosclerosis.


Does Buerger's exist?

Does Buerger's exist?


Disease of the year swine brucellosis.

Disease of the year swine brucellosis.


Clinical evaluation of the Pap smear and the importance of followup.


New questions in medical morality.

New questions in medical morality.


Self-concept and change-seeking need of first-year student nurses.


Mosquito control agents derived from petroleum hydrocarbons. 3. The effect of FLIT MLO on first and second larval instars.


Reexamination of reinforcement in the learning process.


Students' opinions concerning patient selection for clinical practice.


Liability for malpractice...its role in nursing education.


A creative approach to curriculum development.


The undescended testis.

The undescended testis.


Synthesis and decomposition of aminoacetone in sera of healthy subjects and of patients with various internal diseases.


Gastrin inhibition of histamine-induced gastric secretion.


Multiple forms of methemoglobin reductase.


Comparative immunochemical behavior of acid polysaccharides of Cryptococcus laurentii, Tremella mesenterica and of oxidized cellulose with a type II antipneumococcal serum.


Comparison of ipecac-induced emesis with gastric lavage in the treatment of acute salicylate ingestion.


Preparation and pharmacological activity of pyrazole derivatives with potential antihistaminic properties. II. An attempted synthesis of 1-phenyland 1-benzyl-3-methyl-5-pyrazolones aminoalkylated at position 2.


Effects of neomycin and penicillin administration on mucosal proliferation of the mouse small intestine. With morphological and functional correlations. The effects of an oral neomycin and penicillin regimen on intestinal bacteriology and on morphology and function of the small intestine of mice were investigated. Quantitative and qualitative stool cultures on selective media of the treated animals revealed only growth of yeast organisms. The treated animals developed enlargement of the ceca with fluid contents and watery stools, resembling characteristics of germfree animals. Radioautography with tritiated thymidine revealed an increased epithelial cell migration rate in the mice treated with the antibiotics for 3 to 5 wk. A slight increase in villus height was also noted. The treated male mice showed greater variance than the treated females in epithelial cell migration rates. Histochemical staining reactions showed a decrease in nonspecific esterase and in NADH dehydrogenase activity in the proximal gut of the antibiotic animals. Stains of distal gut and those for acid and alkaline phosphatase, NADPH dehydrogenase, lactic dehydrogenase, and succinic dehydrogenase were similar to the controls. A slight increase in sucrase activity and a slight decrease in lactase activity in the antibiotic animals was observed in contrast to control animals. Germfree mice, however, had greater sucrase and lactase activity. Transport of L-methionine was slightly reduced in the distal segment of the treated animals. Since the direction of these changes is away from the intestinal state observed in germfree animals, they are probably the result of the direct action of the antibiotics on the gut.


Molecular quantum mechanics in biology.

Molecular quantum mechanics in biology.


Dental caries experience of Negro and Caucasianchildren in Portland, Oregon.


Influence of pronethalol on ouabain toxicity in dogs treated with reserpine.


Methodology for clinical trials of drugs affecting the nasal airways.


Effect of ionizing radiation on excretion of the biotransformation products of pyridine coenzymes in rat urine.


The effect of sustained release hexocyclium tablets on gastric acid secretion.


Effect of streptovaricin on RNA synthesis in phage T4-infected Escherichia coli.


Concerted inhibition of NADPplus-specific isocitrate dehydrogenase and the implications for metabolic regulation.


Effect of oxamate, pyruvate, nicotinamide and streptozotocin on the pentose phosphate pathway intermediates in ascites tumour cells.


Resistance of beta-haemolytic streptococci and pneumococci to the tetracyclines.


Histologic changes in the testis following anatomically successful orchidopexy.


Technique for the prolonged exposure of animals to a controlled atmosphere.


Histochemistry of 3 beta-hydroxysteroid dehydrogenase in human testis in normal, dysgenetic and various pathological conditions.


Studies on the microsomal drug-metabolizing enzyme system--effect of isooctane and pyridine nucleotides.


Intracellular distribution of pyridine nucleotides in the liver of rats after long-term exposure to carbon disulphide.


D-aspartate oxidase from pig kidney. VII. Protection by competitive inhibitors against thermal inactivation.


Clinical judgment from the MMPI: simple or complex?


Congenital hemiatrophy.

Congenital hemiatrophy.


Anxiety and temporal perspective.

Anxiety and temporal perspective.


The performance of male prisoners on the Marlowe-Crowne social desirability scale. II. Differences as a function of race and crime.


"Organic" vs. "functional" diagnoses from 1-3 MMPI profiles.


Myocardial infarction and ischaemic heart disease in infants and children. Analysis of 29 cases and review of the literature.


Size of figure drawing in relation to depression.


Personality traits as related to symptomatology and running performance at altitude under normal and drug (acetazoleamide) conditions.


Multiple endocrine adenomatosis presenting as Cushing's syndrome and concurrent hyperparathyroidism with massive gastric hemorrhage. (Case report with ACTH, parathyroid hormone, and gastrin assays).


Regulation of the synthesis of rat liver serine dehydratase by adenosine 3', 5'- cyclic monophosphate.


CO2 fixation by malic enzyme in a species of Micrococcus.


Effect of alpha-methyltyrosine on the electrocorticogram of unrestrained rats.


Sympathetic nervous control of adipose tissue lipolysis.


Evaluation of antispasmodic and related activity in the intact dog.


Further study of performance errors on Ravens progressive matrics (1938).


MMPI profiles of parents of young retarded children.


The effect of endotoxin and thorotrast on inducible enzymes in the isolated, perfused rat liver.


Mechanism of the TPNH-linked reduction of methemoglobin by methylene blue.


Metabolic dependence of red cell deformability. The contribution of the metabolic state of human erythrocytes to maintenance of cellular deformability was studied during and after in vitro incubation in serum for periods up to 28 hr. An initial loss of membrane deformability became apparent between 4 and 6 hr when cellular adenosine triphosphate (ATP) levels were approximately 70% of initial values. Membrane deformability then remained stable between 6 and 10 hr. After 10 hr, when cellular ATP had decreased to < 15% of initial values, progressive parallel changes occurred in red cell calcium which increased 400% by 24 hr and in the viscosity of red cell suspensions which had risen 500-750% at 24 hr. A further progressive decrease in membrane deformability also occurred and was reflected by a 1000% increase in negative pressure required to deform the membrane. Red cell filterability decreased to zero as the disc-sphere shape transformation ensued. These changes were accompanied by an increase in ghost residual hemoglobin and nonhemoglobin protein. Regeneration of ATP in depleted cells by incubation with adenosine produced significant reversal of these changes, even in the presence of ouabain. Introduction of calcium into reconstituted ghosts prepared from fresh red cells mimicked the depleted state, and introduction of ATP, ethylenediamine tetraacetate (EDTA), and magnesium into depleted cells mimicked the adenosine effects in intact depleted cells. ATP added externally to 24-hr depleted cells was without effect. Simultaneous introduction of EDTA, ATP, or magnesium along with calcium into reconstituted ghosts prevented the marked decrease in deformability produced by calcium alone. Incorporation of adenosine diphosphate (ADP), nicotinamide adenine dinucleotide (NAD), NAD phosphate (NADP), NADP, reduced form (NADPH), glutatione, reduced form (GSH), inosine triphosphate (ITP), guanosine triphosphate (GTP), and uridine triphosphate (UTP) was without effect. These data suggest that a major role of ATP in maintenance of red cell viability relates to preservation of red cell membrane deformability. It is proposed that the changes seen in the physical properties of ATP-depleted erythrocytes represent ATP-calcium-dependent sol-gel changes occurring at the interface between the membrane and the cell interior, and that the sol-gel balance determines membrane deformability.


Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells. A method was described for the sensitization of erythrocytes with purified type-specific pneumococcal polysaccharide antigens using chromium chloride as a coupling agent. Erythrocytes so sensitized can be used in routine passive hemagglutination and hemolysis tests as well as in the technique of localized hemolysis-in-gel for the detection of specific antibody and specific antibody-producing cells, respectively.


In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. Concentrations of cephalexin (an orally absorbed derivative of cephalosporin C) in serum and urine were determined in normal volunteers and patients. The in vitro antibacterial activity was also studied. All strains of group A beta-hemolytic streptococci and Diplococcus pneumoniae were inhibited by 3.1 mug/ml. Of the Staphylococcus aureus strains, 88% were inhibited by 6.3 mug/ml, and 12.5 mug/ml was inhibitory for all S. aureus, 80% of Escherichia coli, 72% of Klebsiella-Aerobacter, and 56% of Proteus mirabilis strains. About 90 to 96% of E. coli, Klebsiella Aerobacter, and P. mirabilis strains were inhibited by 25 mug of cephalexin per ml. Pseudomonas and indole-positive Proteus strains proved to be quite resistant to cephalexin. Cephalexin was well absorbed after oral administration. A peak serum concentration of cephalexin of at least 5 mug/ml was achieved in each volunteer with 250 and 500-mg doses. A mean peak serum concentration of 7.7 mug/ml was achieved with 250-mg doses; 12.3mug/ml was achieved with 500-mg doses of antibiotic. Food did not interfere with absorption. Probenecid enhanced both the peak serum concentration and the duration of antibiotic activity in the serum. Over 90% of the administered dose was excreted in the urine within 6 hr. The mean peak serum concentration of cephalexin after an oral dose of 500 mg was adequate to inhibit all group A streptococci, D. pneumoniae, and S. aureus, 85% of E. coli, and about 40 to 75% of Klebsiella-Aerobacter and P. mirabilis strains. Levels of cephalexin in urine were adequate to inhibit over 90% of E. coli, and P. mirabilis and 80 to 96% of Klebsiella-Aerobacter strains.


On the synthesis of tyrosine transaminase in vitro.


Objective measures of suspiciousness.

Objective measures of suspiciousness.


Habituation of the orienting response as a function of individual differences in anxiety and autonomic lability.


Relationship between voice-quality profiles and MMPI profiles in psychiatric patients.


A reexamination of the relationship between body boundary and site of disease.


The hysteria and psychiasthenia constructs as an alternative to manifest anxiety and conflict-free ego functions.


Experience with vaccines--general comments.


Effect of prednisolone on the development of cinchophen ulcer in the dog.


Giant cell arteritis: a common disease of the elderly.


Malic enzyme of Escherichia coli. Diversity of the effectors controlling enzyme activity.


Malic enzyme of Escherichia coli. Possible mechanism for allosteric effects.


Isolation of old yellow enzyme in free and complexed forms.


Regulatory mechanisms involving nicotinamide adenine nucleotides as all teric effectors. II. Control of phosphoenolpyruvate carboxykinase.


Biosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene.


Interaction between ferredoxin and ferredoxin nicotinamide adenine dinucleotide phosphate reductase in pyridine nucleotide photoreduction and some partial reactions. I. Inhibition of ferredoxin nicotinamide adenine dinucleotide phosphate reductase by ferredoxin.