Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction. At least two functionally different types of ribosomes are found in strains of Staphylococcus aureus which display "dissociated" resistance to erythromycin. One type of ribosome is found under conditions of growth in ordinary nutrient broth, and the second is formed during growth in the presence of erythromycin. In these strains, erythromycin acts as an inducer of resistance to three different classes of inhibitors of the 50S ribosomal subunit-the macrolides, lincosamides, and streptogramin B-type antibiotics. The optimal inducing concentration of erythromycin is between 10(-8) and 10(-7)m. Concentrations as low as 10(-9)m can produce a 10-fold increase in resistant cells over the uninduced, background level, whereas concentrations greater than 10(-7)m block induction owing to inhibition of protein synthesis. Resistant cells begin to appear within 5 to 10 min after addition of erythromycin (to 10(-7)m), and within 40 min (i.e., about one generation) more than 90% of the entire culture is resistant to erythromycin as well as to lincomycin and vernamycin B(alpha). A resistant culture becomes sensitive if grown for 90 min in the absence of erythromycin. The process of induction is inhibited by chloramphenicol and streptovaricin, which inhibit protein and ribonucleic acid synthesis, respectively, but not by novobiocin, which inhibits deoxyribonucleic acid synthesis. Resistant cells produced in this manner fail to concentrate (14)C-erythromycin and (14)C-lincomycin, but not (14)C-chloramphenicol. Constitutively erythromycin-resistant strains which do not require the presence of erythromycin for expression of resistance can be selected on media containing antibiotics which belong to any one of the three classes. Two patterns of constitutive resistance have been found. These are (i) generalized constitutive resistance-which involves resistance in the absence of erythromycin to all members of each of the three cited classes of 50S subunit inhibitors which were tested, and (ii) partial constitutive resistance-which involves different degrees of resistance, in the absence of erythromycin, to various members of the three classes. Several different patterns of variable constitutivity are possible. 50S ribosomal subunits isolated from induced or constitutively resistant cells show decreased ability to bind erythromycin and lincomycin, and possible enzymatic inactivation of these antibiotics has been rigorously excluded. The induced change, therefore involves modification of ribosome structure rather than modification of the antibiotic.


The relationship of PD and MAS scores to approach-avoidance behavior under immediate versus delayed punishment.


H group method of profile analysis.

H group method of profile analysis.


Factor analysis of items on the social introversion and masculinity-femininity scales of the MMPI.


Self-ratings and inventory scores in the measurement of social introversion.


Differences between older institutionalized offenders and nonoffenders on MMPI hostility and control scales.


Client evaluation of therapist strength and positive-negative evaluation as related to client dynamics, objective ratings of competency and outcome.


Estimation of natural antihistamine activity in the urine and blood of man.


On the biology of Simulium damnosum Theoblad, 1903, the main vector of onchocerciasis in the Mahenge mountains, Ulanga, Tanzania.


Suitable blood sources permitting reacquisition of infectivity of culture-form. Trypanosoma (Trypanosoma (Trypanozoon) brucei.


pH-dependent inactivation of nicotinamide--adenine dinucleotide glycohydrolase by its substrate, oxidized nicotinamide--adenine dinucleotide.


Results of double-blind, multicentre study with ritodrine in premature labour. A double-blind placebo-controlled multicentre study with ritodrine, a beta-mimetic uterine relaxant, has been performed in 91 patients in premature labour. All patients were treated according to a fixed dosage scheme consisting of an intravenous infusion followed by oral tablets for a total of seven days. Ritodrine arrested premature labour in 80%, the placebo in 48% of the patients (P=0.02). This short treatment, however, was usually not sufficient to prolong gestation till term. Apart from a slight to moderate rise in maternal heart rate and a slight rise in systolic blood pressure, ritodrine did not give rise to any maternal or fetal side effects. The problems of patient selection and of evaluation of the results are discussed.


Changes in the free nucleotide pool during growth in cultures of Polytoma uvella.


The effect on subsequent fertility of temporary cryptorchidization in Swiss white mice.


Comparison of adrenergic beta-blocking drugs in angina pectoris. The symptomatic, electrocardiographic, and haemodynamic effects of two adrenergic beta-blocking drugs, oxprenolol and propranolol, have been compared in equipotent intravenous doses in six patients with uncomplicated angina pectoris during treadmill exercise. The method of comparison included double-blind assessment and analysis with placebo control and randomized serial comparison in each patient. Both drugs produced an equal amelioration in symptoms in most of the patients. This was closely correlated with improvement in the electrocardiographic changes and a significant reduction in the exercising heart rate and systemic arterial pressure. This method of double-blind combined subjective and objective assessment carries distinct advantages in the comparative assessment of drug treatments in angina pectoris.


Alterations of enzymatic activities during muscle differentiation in vitro.


Estrogen and castration-induced effects on canine prostatic fine structure and C-19-steroid metabolism.


Studies on the immunosuppressive properties of asparaginase.


Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates. Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells. Such a nonimmunogenic compound (DNP-D-GL) will nevertheless elicit a DNP-specific anamnestic antibody response when administered at an appropriate time to DNP-ovalbumin-primed guinea pigs undergoing a graft-versus-host reaction. These experiments are discussed in terms of a two-cell theory of stimulation of antibody responses.


Peculiar immunobiology of bone marrow allografts. I. Graft rejection by irradiated responder mice. Mice are capable of rejecting H-2-incompatible bone marrow grafts after a single lethal exposure to X-rays. The onset of rejection begins 18-24 hr after transplantation and is completed by 96 hr. Maturation of this type of allograft reactivity does not occur until the 22nd day of life. In adult mice, the resistance to marrow allografts can be weakened by administration of cyclophosphamide or dead cultures of Corynebacterium parvum, but not heterologous anti-thymocyte serum. Sublethal exposures to X-rays 7 or 14 days before transplantation also weaken resistance. There is considerable interstrain variation in the ability of mice to resist allografts, even when H-2 differences between hosts and donor are kept identical. Although H-2 incompatibility is a necessary prerequisite for resistance, additional genetic factors influence the outcome of marrow allografts, presumably by controlling recognition. The regulator genes are determinant specific and the alleles for resistance or responder status appear to be dominant. The responder phenotype is expressed by hemopoietic cells and not by the environment. Accordingly, resistance is conferred to otherwise susceptible mice upon transfer of bone marrow cells but not of serum. The production and differentiation of effector cells for marrow graft rejection are thymus independent. In conclusion, bone marrow allografts elicit a particular transplantation reaction, previously unknown, in irradiated mice. Peculiar features of this reaction are the lack of proliferation of host lymphoid cells, tissue specificity, thymus independence, and regulation by genetic factors which apparently do not affect the fate of other grafts.


A psycho-pharmacological analysis of behaviour in rats.


Further studies on the sympathomimetic action of tetanus toxin.


Pharmacological studies on 8-[(1,4-benzodioxan-2-yl) methyl]-3-oxo-1-thia-4,8-diazaspiro-[4,5]-decane maleate.


Effectiveness of a stannous fluoride dentifrice on dental caries.


No need for physicians' assistants in South Africa.


Studies on tetrahydroisoquinolines (THI). 8. Pharmacological properties of metabolites of a new adrenergic  -stimulant, trimetoquinol.


Fatty acid synthetases from Euglena gracilis.


Biosynthesis of sphingolipid bases. IV. The biosynthetic origin of sphingosine in Hansenula ciferri.


Fat metabolism in higher plants. XLIV. Fatty acid synthesis by a soluble fatty acid synthetase from Sclanum tuberosum.


Purification and properties of thyroidal UDP-glucose-4-epimerase.


Address of the past President.

Address of the past President.


Oxidation of biologically active reducing substances by ozone.


The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.


Survival of group A erythrocytes following bone marrow transplantation for reconstruction of lymphopenic hypogammaglobulinemia.


Ventricular function in anemia.

Ventricular function in anemia.


The oral epidemiology of various ethnic groups in selected rural communities of Israel.


Initial management of acute poisoning.

Initial management of acute poisoning.


Xenogeneic graft-versus-host reactions. Assay system for antilymphocytic sera?


The rapid, enzymatic determination of glucose in hemolysates.


Angina pectoris: pathophysiology, evaluation, and treatment.


Neuroleptanalgesia for patients with kidney malfunction.


Should nurses do physical examinations?

Should nurses do physical examinations?


Pharmacological effects of H 56-28: a new  -antagonist on the cardiovascular system.


Presynaptic inhibition in the vertebrate central nervous system.


Ten years in retrospect.

Ten years in retrospect.


A hypothetical synaptic-neural-behavioral model of operant learning.


Acute pulmonary disease and sickle cell anemia.


The permissive role of cortisol in the regulation of rat liver tyrosine aminotransferase.


Properties of an NADP plus-specific isocitric dehydrogenase from Thiobacillus novellus.


The effect of temperature and of cofactor concentrations on the conversion of 4- 14 C-progesterone to corticosterone by rat adrenal preparations.


Prolonged administration of antithymocyte serum in mice. I. Observations on cellular and humoral immunity.


Kinetic mechanism of phosphorylase a. I. Initial velocity studies.


Steroid biosynthesis by the American bullfrog (Rana catesbeiana) interrenals. II. In vitro studies with cholesterol-4-14 C and acetate-1-14 C.


Steroid biosynthesis by the American bullfrog (Rana catesbeiana) interrenals. I. In vitro studies with progesterone-4-14 C and delta 5-pregnenolone-4-14 C.


The impact of imprisonment on selected attitudes of recidivists and first offenders.


Clinical judgments of client pathology and subsequent client improvement.


Relationships among education, the MMPI, and WAIS measures of psychopathology.


The relationship of rate of change of heart rate to MMPI variables.


A moderator variable approach to MMPI validity.


The relationship of defensiveness to responses on the sex inventory.


Comparison of MMPI scores of mothers of enuretic and control children.


A behavioral approach to the group treatment of depressed persons: a methodological contribution.


Cholesterol, cholesterol esters and cholesterol esterase in the sciatic nerve during development of the chick.


Diphenylhydantoin.

Diphenylhydantoin.


Effects of different drugs with beta-adrenolytic activity on experimental models of arrhythmias.


Medical treatment of cardiac arrhythmias.


Delayed bone marrow aplasia in rats protected against lethal irradiation by allogeneic marrow transplantation.


General concepts in the use of beta-blockers: the relative roles of specific and unspecific effects.


Pharmacological control of lipid transport.


The second messenger concept and lipid metabolism.


A clinical study of ram infertilities in Scotland.


A rationale for the treatment of symptoms in allergic diseases.


Microsomal oxidation of alpha-thiocarboxylic acids to sulfoxides.


Glucose effect on tryptophan oxygenase and tyrosine aminotransferase induction after allylisopropylacetamide-induced porphyria in the rat.


Preparation of antisera against cytochrome b 5  and NADPH-cytochrome c reductase from rat liver microsomes.


Cellular and humoral response to transplantation antigens. I. Development of alloantibody-forming cells and cytotoxic lymphocytes in the graft-versus-host reaction. After transfer into heavily-irradiated allogeneic mice, spleen cells were found to produce two types of effector cells directed against the recipient alloantigens, namely alloantibody plaque-forming cells (PFC) and cytotoxic lymphocytes (CL). Both types of effector cells were detectable in vitro by virtue of their lytic effect on target cells carrying the recipient alloantigens. Alloantibody PFC activity was dependent on the presence of an exogenous source of complement and could be inhibited by the addition of heterologous antisera to mouse micro-chain or Fab fragment in the assay system. CL activity was independent of added complement, was not affected by anti-immunoglobulin antisera, but was inhibited by the addition of antibody against target cell alloantigens. Treatment of the transferred spleen cells with anti-theta-serum and complement before in vitro assays for PFC and CL completely abolished the CL activity but had no effect on alloantibody-plaque formation. These results indicate that the two types of effector cells can be differentiated in vitro by virtue of their susceptibility to anti-theta-serum and the mechanisms by which they cause cell lysis.


A comparative study of dextro-alprenolol, dextro-propranolol and practolol in the treatment of ventricular ectopic beats.


A phase-rule study of multiple-phase formation in a model emulsion system containing water, n-octanol, n-dodecane and a non-ionic surface-active agent at 10 and 25 degrees.


The kinetics of dissolution for a non-disintegrating standard substrate.


The influence of compression and formulation on the hardness, disintegration, dissolution, absorption and excretion of sulphadimidine tablets.


The quantitative analysis of polyvinylpyrrolidone by infrared spectrophotometry.


The mechanism of the inhibitory action of salicylate on glutamyl-transfer ribonucleic acid synthetase in vitro.


The neuromuscular blocking activity of some monoquaternary androstane derivatives.


Some 5-hydroxytryptamine-like actions of fenfluramine: a comparison with (+)-amphetamine and diethylpropion.


Effect of amphetamine on the uptake, release and effectiveness of xylocholine in the guinea-pig vas deferens.


The structure of buckwheat, Fagopyrum esculentum Moench.


The effect of beta-phenethylamine on noradrenaline concentrations in guinea-pig brain.


Resistance to tetrodotoxin in the isolated ileum of the rat.


Maintenance of noradrenaline in neuronal cell bodies and terminals: effect of frequency of stimulation.


In vitro study of mutual antagonism between alpha-and beta-adrenoreceptor blocking agents.


The muscarinic and nicotinic activities of some esters related to acetylcholine.


Antagonism of acetylcholine-induced bronchospasm by WG 253, a new sympathomimetic amine.


A comparison of the effects of isoprenaline, WG 253 and salbutamol on the tension and rate of rabbit isolated atria.


On the presence of histidine decarboxylase activity in rat forestomach.


The effect of hypoxia on isonicotinic acid hydrazide-induced seizures in chicks during ontogenesis.


Triglyceride and precursor concentrations in the fatty liver of rats after chronic administration of ethanol.


Angiotensin tachyphylaxis and the uptake of ( 14 C)angiotensin in guinea-pig aortic strips.


Biliary excretion of (14C) edrophonium and its glucuronide conjugate.


A common error in assessing the significance of percentage change in neuropharmacology.


On the nature of the oscillations of the membrane potential (slow waves) produced by acetylcholine or carbachol in intestinal smooth muscle. 1. Intracellular recording was made with glass micro-electrodes from cells of the longitudinal muscle of the guinea-pig ileum in isotonic and in hypertonic solution.2. In isotonic solution spontaneous bursts of electrical activity occurred; these consisted of a slow potential component which carried a burst of spike action potentials. Acetylcholine increased the size (and the frequency) of the slow potential component. This had the effect of first reducing and then abolishing the spike potentials; continuous slow wave activity was thus produced. Slow waves were about 1 sec in duration and up to 50 mV in size in isotonic solution.3. In hypertonic solution the membrane potential was stable. There were no spontaneous spikes and no slow potentials. However, spikes, but not slow potentials, were elicited by depolarizing current. Carbachol (or acetylcholine) reduced the membrane potential and initiated spikes and oscillations of the membrane potential (slow waves). Slow waves were 2-5 sec in duration and 10-40 mV in size in hypertonic solution.4. The response to carbachol in hypertonic solution was unaffected by surgical denervation of the tissue, by tetrodotoxin, or by ganglion blocking agents, indicating that muscarinic stimulants produced their effects by acting directly on the smooth muscle cell.5. In hypertonic solution slow waves occurred only in the presence of a muscarinic stimulant and could not be elicited with depolarizing current (unless carbachol was present) nor by increasing the external potassium concentration.6. In hypertonic solution slow waves were abolished by hyperpolarizing the membrane and their rate of rise was proportional to the level of the membrane potential from which they arose. The membrane resistance was reduced at the peak of the slow wave. Slow waves were rapidly abolished by sodium-deficient solutions but spikes were not.7. It is suggested that slow waves represent an inward current through a slow, sodium-sensitive and voltage-dependent ion channel, and that acetylcholine or carbachol increase, while hypertonic solution decreases, the current carried by this channel.


Evidence against adrenergic motor transmission in the guinea-pig vas deferens. 1. Field stimulation of desheathed preparations of guinea-pig vas deferens, treated with a ganglion-blocking agent, has revealed the presence of two tetrodotoxin-susceptible components in the motor response, suggesting the existence of two sets of post-ganglionic motor nerve fibres of different excitability: one set responding maximally to pulses of 0.1-0.4 msec; the other, to pulses of 2 msec. No distinction could be made pharmacologically between the two components.2. Cooling potentiated that component in the twitch-responses which was due to stimulation of the more excitable fibres.3. The sensitivity of the longitudinal muscle to the motor action of noradrenaline was low and was subject to considerable animal variation. But normal responses to post-ganglionic field stimulation were elicited in noradrenaline-insensitive preparations, in which the twitches elicited by 5 pulses could not be matched with noradrenaline, even 100-125 mug/ml.4. In some forty experiments, small doses of noradrenaline inhibited the twitch-responses evoked by either set of motor fibres. This inhibition differed from that produced by isoprenaline in two respects. Firstly, propranolol did not antagonize the noradrenaline inhibition, thus excluding an action on beta-adrenoceptors; and secondly, noradrenaline did not depress contractions elicited by muscarine or by 5-methylfurmethide.5. Phenoxybenzamine, 10(-6) g/ml., produced a thousandfold reduction in the sensitivity of the muscle to the motor action of noradrenaline, without any decrease in the height of the twitches elicited by 0.1 or 1 msec pulses.6. The twitch-responses were not affected by combined alpha + beta adrenoceptor blockade with phentolamine and propranolol.7. Tyramine, amphetamine, tranylcypromine and prostaglandin E(2) inhibited the twitches but potentiated the contractile effect of noradrenaline.8. The twitch-responses and their inhibition by noradrenaline were present in preparations taken from reserpinized animals.9. Although the twitch-responses could be paralysed by bretylium or guanethidine, the foregoing results excluded adrenergic transmission at the motor endings. Cholinergic transmission was also excluded by negative findings with anticholinesterases, atropine, nicotine and (+)-tubocurarine.10. Motor transmission by histamine, 5-hydroxytryptamine, gamma-aminobutyric acid or ATP was also excluded.


Mechanism of oxidative carbon dioxide production during Renilla reniformis bioluminescence. The oxidation of luciferin catalyzed by sea pansy luciferase results in the emission of light. Molecular oxygen is required and carbon dioxide is produced. When the reaction occurs in the presence of H(2) (18)O, both of the oxygens of the carbon dioxide are labeled. One of the oxygens arises from the nonenzymic exchange of the ketone group of the substrate; the other oxygen is incorporated during the enzymic oxidation of the luciferin. When the reaction is carried out in the presence of (18)O(2), neither of the oxygens of the carbon dioxide is labeled. Thus the source of oxygen in the carbon dioxide is water. A mechanism for the oxidative reaction is proposed.


Evaluation of antimalarial compounds in mosquito test systems.


Dental and oral conditions in a group of mental retardates attending occupation day centers.


Rapid enzymic methods for determination of the specific radioactivity of metabolic intermediates in unpurified brain tissue extracts.


"Free" and "bound" acetylcholine concentrations in rat brain: variability in determination of "free" acetylcholine fraction.


Steroid hormones and enzyme induction.

Steroid hormones and enzyme induction.


Emergency medical care in the Soviet Union. A study of the Skoraya.


The neuro-humoral mechanisms of hypothalamic integrative processes.


Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital. In the supernatant fraction of homogenized rat liver, the activity of aldehyde dehydrogenase that is dependent on nicotinamide adenine dinucleotide (E.C. 1.2.1.3) is increased up to tenfold after administration of phenobarbital for 3 days. The effect is genetically controlled and is inherited as an autosomal dominant characteristic. The mechanism is apparently unrelated to other druginduced increases in enzyme activity such as that which occurs in the hepatic microsomal systems for drug metabolism.


Dimorphism of adiphenine hydrochloride.

Dimorphism of adiphenine hydrochloride.


Tyrosine transaminase induction: differential effect of 5-azacytidine on liver and hepatoma 5123D.


Time-motion study of pediatric nurse practitioners: comparison with "regular" office nurses and pediatricians.


The RN obstetric assistant: a clinical trial.


Factors controlling the flux of glucose through the pentose phosphate pathway.


A gastric acid inhibitor of cerebral origin.


Haemocytic periodicity and periodic disorders: periodic neutropenia, thrombocytopenia, lymphocytosis and anaemia.


On the reversibility of the energy-linked transhydrogenase.


Pyridine nucleotide oxidation by intact human polymorphonuclear neutrophils.


Some peculiar aspects in the treatment of cardiac arrest.


Inhibitory site of carbonyl cyanide m-chlorophenylhydrazone in the electron transfer system of the chlorophasts.


Anaesthetic management of pheochromocytoma: a case report.


Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.


The effect of some beta-adrenoceptive blocking drugs on glucose-6-phosphate and fructose-1,6-phosphate levels, and on hexokinase activity in the mouse brain.


Drug interactions with coumarin anticoagulants. 2.


Utilization of allied health workers: does it solve the basic problem?


Functional studies of right cardiac sympathetic nerves and ganglia in the dog.


Use of allied health professionals in internists' offices. Current practices and physicians' attitudes.


Effects of isoprenaline and aminophylline on the chronotropic responses of the isolated guineapig heart to vagal stimulation and acetylcholine. 1. In isolated perfused guinea-pig hearts, isoprenaline (2 x 10(-8) g/ml) reduced the negative chronotropic responses to vagal stimulation and to exogenous acetylcholine.2. The beta-adrenoceptor antagonist LB46 (2 x 10(-8) g/ml) abolished the effect of isoprenaline in reducing vagal bradycardia. LB46 itself did not alter the responses to vagal stimulation.3. Increase in (86)Rb efflux induced by acetylcholine was not affected by isoprenaline.4. Aminophylline (2.3 x 10(-4) g/ml) almost abolished the negative chronotropic effect of vagal stimulation.5. The ;antivagal' effects of isoprenaline and aminophylline may be at a common site beyond the level of the cardiac beta-adrenoceptors, perhaps related to cyclic-3',5'-AMP and/or sodium transport.


A prune belly (triad syndrome).

A prune belly (triad syndrome).


Adrenoceptor functions in the cat choledochoduodenal junction in vitro. 1. The effects of alpha- and beta-adrenoceptor stimulating agents were investigated on three different kinds of preparation of the isolated sphincter of Oddi and on the duodenum of the cat.2. Adrenaline (1.5 x 10(-7)M-6.3 x 10(-7)M), noradrenaline (1.6 x 10(-7)M-6.3 x 10(-7)M), and tyramine (2.9 x 10(-6)M-5.8 x 10(-6)M) increased the activity and tonus of the sphincter musculature and decreased duodenal activity and tone. The effect on the sphincter resulted in increased resistance to flow through the sphincter. The excitatory effects on the sphincter were blocked by phenoxybenzamine (1.7 x 10(-8)M-1.7 x 10(-7)M).3. No effect was produced by tyramine in concentrations up to 4.6 x 10(-5)M on sphincters taken from reserpinized cats. It is suggested that the cat sphincter of Oddi contains adrenergic nerves of functional importance.4. Isoprenaline (1.9 x 10(-8)M-4.7 x 10(-7)M) and terbutaline (3.5 x 10(-7)M-8.8 x 10(-6)M) decreased spontaneous activity and tonus of the sphincter, and diminished resistance to flow through the sphincter. Both agents decreased spontaneous activity and tonus of the duodenum. On a molar basis, isoprenaline was 2-18 times more active than terbutaline on the sphincter and 35-90 times more active on the duodenum. The effects of isoprenaline and terbutaline were blocked by propranolol (3.9 x 10(-7)M).5. It is concluded that the cat sphincter of Oddi contains alpha-adrenoceptors active in contraction of the sphincter, and beta-adrenoceptors active in its relaxation. The beta-adrenoceptors of the sphincter differ from those in the duodenum; it is suggested that they belong to the beta(2)-group (according to Lands' classification).6. The automaticity of the isolated sphincter of Oddi resembled the sphincter activity recorded in vivo and is probably myogenic in nature, as it resisted treatment with phenoxybenzamine (1.7 x 10(-8)M-1.7 x 10(-7)M), atropine (1.4 x 10(-6)M-5.8 x 10(-6)M), hexamethonium (1.4 x 10(-5)M-1.1 x 10(-4)M) and tetrodotoxin (1 mug/ml). The activity of the sphincter has no propulsive function but prevents passage of fluid through the sphincter.


The action of beta-adrenergic blocking and stimulating agents on insulin secretion. Characterization of the type of beta receptor.


Transplantation tolerance following transfer of donor spleen cells in adult animals.


Studies of protracted shock in guinea pigs.


Physician's assistants. A review of their status.


Immune reactions to Nippostrongylus brasiliensis in the rat. Immunological and pharmacological analysis of primary and secondary immune response.


The subcellular localization of lipolytic enzymes in pig aorta.


The structural basis of muscular contraction.


Motility and energy-rich phosphorus compounds in spermatozoa of Octopus dofleini martini.


Retinal anatomy in some scopelarchid deep-sea fishes.


Cuticle reflectivity and optical activity in scarab beetles: the rôle of uric acid.


The serum concentration of bactericidal antibiotics (rifampicin, cephaloridine) in relation to the low resistance period in experimental infections. Immunological investigations in experimental chemotherapy. V.


The role of the low resistance period in determining the effective dosage of chlortetracycline in mice. Immunological investigations in experimental chemotherapy. IV.


Question of norepinephrine release in the action of cardiac glycosides.


Initial velocity studies of the reverse citrate cleavage reaction.


Approach to a chemical interpretation of the activation mechanism of adrenergic receptors.


Aldose reductase from Rhodotorula. I. Purification and properties.


The metabolism of aromatic compounds in higer plants. X. Properties of the cinnamic acid 4-hydroxylase of pea seedlings and some aspects of its metabolic and developmental control.


The MMPI: a case study in dissimulation.


Education and MMPI Mf scores in homosexual and heterosexual males.


Defensiveness of the MMPI as a function of the warmth of test introduction.


MMPI item differences between smoker and nonsmoker college freshmen males.


Psychophysical approach to clinical judgment of low T scores on the MMPI.


On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.


Microsomal electron transport reactions. II. The use of reduced triphosphopyridine nucleotide and-or reduced diphosphopyridine nucleotide for the oxidative N-demethylation of aminopyrine and other drug substrates.


Microsomal electron transport reactions. I. Interaction of reduced triphosphopyridine nucleotide during the oxidative demethylation of aminopyrine and cytochrome b 5  reduction.


Microsomal electron transport reactions. 3. Cooperative interactions between reduced diphosphopyridine nucleotide and reduced triphosphopyridine nucleotide linked reactions.


[Gas chromatographic determination of caffeine and pyrilamine in association and in the presence of other drugs].


Evidence for the participation of cytochrome b 5  in hepatic microsomal mixed-function oxidation reactions.


Clinical status and toxicology of analeptic drugs.


Escherichia coli nicotinamide adenine nucleotide transhydrogenase driven by aerobic oxidation and its enhancement by an energy transfer factor from rat-liver mitochondria.


Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes.


Preparation of glutamate dehydrogenase from Micrococcus aerogenes.


Resolution of enzymes catalyzing energy-linked transhydrogenation. 3. Preparation and properties of Rhodospirillum rubrum transhydrogenase factor.


Resolution of enzymes catalyzing energy-linked transhydrogenation. II. Interaction of transhydrogenase factor with Rhodospirillum rubrum chromatophore membrane.


Pyridine nucleotide requirements of fatty acid synthetases.


Glucose (hexose 6-phosphate) dehydrogenase in liver of rainbow trout.


Dental service at Teamster Comprehensive Care Program, Montefiore Hospital and Medical Center.


Cornea and sclera.

Cornea and sclera.


Adapt or perish.

Adapt or perish.


Renal transplantation in high-risk patients.


Studies on the role of catecholamines as regulators of tyrosine aminotransferase.


Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1).


Selective protection of serotonin stores against the action of reserpine by  -methyl-5-hydroxytryptpohan pretreatment.


Induction of tyrosine aminotransferase by phentolamine.


Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.


On glutamate-NAD(P)-oxidoreductase activity in the red blood cells.


Ampicillin trihydrate in the treatment of acute otitis media in children.


Otitis media: microbiology and evaluation of therapy.


An approach to acute respiratory infection in children.


Role of Hemophilus influenzae in pediatric respiratory infections.


Broad-spectrum penicillins and other antibiotics in the treatment of surgical infections.


Cerebrospinal fluid levels of ampicillin and penicillin during pneumococcal meningitis: experimental studies in dogs.


The penetration of broad-spectrum antibiotics into the cerebrospinal fluid.


Bacterial meningitis.

Bacterial meningitis.


Preliminary evaluation of hetacillin in the treatment of acute bacterial meningitis.


Histo-pathological changes in cold-exposed kangaroo rats, Dipodomys merriami.


Utilization of ammonium ions for purine precursor synthesis in soluble extracts of Ehrlich ascites cells.


Energy metabolism and body water turnover rates of two species of free-living kangaroo rats, Dipodomys merriami and Dipodomys microps.


Temperature regulation in the somali donkey (Equus asinus).


Tissue K concentration in relation to the role of the kidney in hibernation and the cause of periodic arousal.


Long period rhythms of liver glycogen content.


Electric characteristics of the cellular and nuclear membranes of the salivary gland cells of Drosophila funebris larvae.


Chronic restraint and glycine, phenylalanine and oleic acid absorption.


Chemical control of feeding behavior.

Chemical control of feeding behavior.


Bladder diverticulum.

Bladder diverticulum.


Psoas abscess in Crohn's disease.

Psoas abscess in Crohn's disease.


Electrocardiographic abnormality during non-exertional angina.


New advances in the treatment of human anovulatory infertility.


Doctors and hospitals must report child abuse: recent Supreme Court ruling doesn't invalidate state law.


The development of methemoglobin in mothers and newborn infants from nitrate in water supplies.


Treatment of hypertensive crisis.

Treatment of hypertensive crisis.


Is pressure work of the isolated canine heart dependent on release of catecholamines?


Cardioselective beta-receptor stimulant properties of oxyfedrine.


Clinical status and toxicology of analeptic drugs.


NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis.


A possible role for pituitary function in the age-dependent regulation of hepatic tyrosine aminotransferase activity.


The formation of 3,4-dihydroxy-L-phenylalanine from L-meta-tyrosine by rat liver and beef adrenal medulla.


Physiological functions of NAD- and NADP-linked malic enzymes in Escherichia coli.


Phosphate catalysis in the autoxidation of 1-n-propyl-6-hydroxy-1,4,5,6-tetrahydronicotinamide. A model for adenosine triphosphate formation.


Kinetic and isotope-exchange studies on shikimate dehydrogenase from Pisum sativum.


Identification of phospholipase A 1  and A 2  in the soluble fraction of rat liver lysosomes.


Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants. Mutant strains of Escherichia coli have been isolated in which the synthesis of two of the enzymes involved in tyrosine biosynthesis, 3-deoxy-d-arabinoheptulosonic acid-7 phosphate synthetase (tyr) and chorismate mutase T-prephenate dehydrogenase, is partially constitutive. The mutations involved are closely linked to aroF and tyrA, the structural genes of these enzymes. The gene in which the mutations occur has been designated aroK, and the gene sequence is aroK, aroF, tyrA. In aroK(+)/aroK diploids, the aroK allele only affects the structural genes in the cis position. The mutant allele aroK is not recessive to aroK(+) and aroK/aroK(+) strains exhibit the aroK phenotype of resistance to 4-aminophenylalanine. It is proposed that aroK is an operator locus for an aroF tyrA operon.


Solubilizing effect of nucleotides on isolated insulin secretory granules.


The seeming effect of tobacco consumption on the occurrence of periodontal disease and dental caries.


Subfractionation of smooth microsomes from rat liver. Total smooth microsomes from rat liver isolated on a Cs(+)-containing sucrose gradient were concentrated and subsequently fractionated by zone centrifugation on a stabilizing sucrose gradient. The prerequisite for fractionation is to prepare total smooth microsomes in a nonaggregated condition, as well as to utilize a procedure which counteracts enzyme inactivation. The median equilibrium density of the various smooth microsomal vesicles ranges from 1.10 to 1.18. The phospholipid/protein ratio is identical in all subfractions, but cholesterol, on a PLP basis, is enriched in the subfractions with the highest sedimentation velocity. The enzyme distribution pattern reveals a pronounced heterogeneity. A number of NADH- and NADPH-oxidizing enzymes are concentrated in the upper part of the gradient and exhibit a certain degree of separation from G6Pase. Mg(++)-ATPase and AMPase are enriched in the lower part of the gradient. No specific enrichment of newly synthesized NADPH-cytochrome c reductase activity occurs in any of the subfractions after phenobarbital treatment. These data demonstrate that smooth microsomes, by adequate fractionation procedure, can be separated into subfractious of heterogeneous composition.


CT1341: further studies in man.

CT1341: further studies in man.


NADPH-regenerating systems in microorganisms producing macrolide antibiotics.


The effect of parathyroid extract on the alkaline phosphatase activity of the surface of isolated bone cells.


Are over-the-counter sleep medications effective? All-night EEG studies.


The frequency of "Allocluster-forming cells" in the lymph nodes of skin-grafted mice as a function of the histocompatibility barrier.


Immunological responsiveness in CBA-PH and C57BL-6 mice and in their first backcross generation.


Androgenic activity and expression of the male-specific antigen in C57BL-6 mice of the Wv-Wv genotype.


A psycho-social study of surviving male coronary patients and controls followed over nine years.


Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H(2)O(2) during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain.


Cholinergic mechanisms in the human uterus.


Hyperbaric oxygen treatment of gangrene in pneumococcemia.


Insect stings.

Insect stings.


Noradrenaline: fate and control of its biosynthesis.


Autonomic responses of male adolescents exhibiting refractory behaviour in school.


Dosimetry of proton radiation fields in space with nuclear emulsions.


The occurrence of some drugs and toxic agents encountered in drinking driver investigations.


Effects of antihistamines on isolation-induced fighting in mice.


Adequate dose excretory urography. Experience with 25,000 cases.


Reactions to intravenous iodides in urography.


Experiences with the midline transabdominal approach in orchiopexy.


Formation of inter-strand cross-linkings in the photoreactions between furocoumarins and DNA.


Putrescine and spermidine changes in heat-synchronized Tetrahymena populations.


On the recovery of x-irradiated bacteria.


Effect of triton X-100 on the galactosyl transferase activity of chick embryo cells.


Cross-bridges between intramacronuclear microtubules and inner nuclear membrane.


A comparison of the cardiovascular actions of four adrenergic  -receptor blocking agents in resting, conscious dogs.


Critical issues in the use of physician associates and assistants.


Partial immunodeficiency and graft-versus host disease.


Cough remedies.

Cough remedies.


Sequential gastrointestinal complications of polyarteritis nodosa.


Malacoplakia of the colon.

Malacoplakia of the colon.


Muscle biopsy at motor point in polyarteritis nodosa.


Notable advances in dermatological treatment over the past twenty-five years.


Patterns of emotional stress in myocardial infarction patients. Periodic assessments of psychological state at discharge and during convalescence.


Educational program in nuclear medicine technology.


Pharmacological features of the gall bladder and its vascular bed of the dog in situ.


Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction.


The influence of propranolol, INPEA, iproveratril and some 1-naphthylethylamine derivatives on the myocardial phosphorylase activity.


Changes in the serum concentration of cholesterol, triglycerides and phospholipids in the mouse and rat after administration of either chlorcyclizine or phenobarbital.


Nitroglycerin biotransformation by rat blood serum.


Hydrocortisone induction of tyrosine aminotransferase activity in genetically obese and diabetic mice--effects of a multiple dosage schedule.


Human liver microsomal drug metabolism.

Human liver microsomal drug metabolism.


Induction of tyrosine aminotransferase in rat liver by epinephrine and theophylline.


Microsomal activation of cyclophosphamide in vivo.


Studies on the regulation of the activity of drug oxidation in rat liver microsomes by androgen and estrogen.


Microsomal epoxidation of aldrin in lepidopterous larvae.


Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.


Modification of an enzyme radiochemical assay procedure for noradrenaline.


Flumethasone induction of liver tyrosine aminotransferase activity in inbred strains and obese mutant mice.


The effect of antihistamines on red blood cell acetylcholinesterase activity in vitro.


Effect of sulthiame on blood and brain levels of diphenylhydantoin in the rat.


Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.


Effect of phenobarbital and chlorcyclizine on the development of atheromatosis in the cholesterol-fed rabbit.


Effect of inhibitors and inducers of drug metabolism on ethanol metabolism in vivo.


Intranuclear metabolism of testosterone in kidneys of male and female rats.


Inhibition of corticosterone formation and 3 -hydroxysteroid dehydrogenase activity in cell-free preparations of rat adrenals.


Insulin release during alpha-adrenergic receptor blockade: primacy of the glycemic stimulus.


Adrenocortical influences on the development of the diurnal rhythm in hepatic tyrosine transaminase.


Oral salbutamol as a supplement too inhaled aerosol in obstructive respiratory disease.


Studies on mechanisms controlling the secretion of neurotransmitters in the rabbit heart.


Steroid hydroxylations in rat adrenal mitochondria. 3. The ATP-steroid-oxygen stoichiometry of ATP-dependent steroid hydroxylation.


The medical research assistant in the pharmaceutical industry.


Anxiety and arousal.

Anxiety and arousal.


The disposition and metabolism of tryptamine and the in vivo formation of 6-hydroxytryptamine in the rabbit.


Effects of some psychotropic drugs on dopamine synthesis in the rat striatum.


Direct and systemic effects of guanethidine on renal function.


Continuing education and the extended role of the nurse or the continuing role of the nurse in extended education.


Postoperative course and treatment in adrenal surgery. II. Cushing's syndrome and pheochromocytoma.


Enhancement of antitumor effect of cyclophosphamide by centrophenoxine.


Antihistaminic activity of synthetic quinoline derivatives.


Post-traumatic calcific hematoma: a case report.


Intelligence and age in discrimination conditioning of the eyelid response.


Treatment of pneumonia in New Guinea. A controlled trial of crystalline penicillin and procaine penicillin aluminium monostearate.


The physician's assistant: licensure and scope of functions.


The utilization of allied health professionals.


The influence of 1-(o-allylphenoxy)-3-isopropylamino-2-propanol hydrochloride (alprenolol) on the central nervous system of the rat.


Allergy as inflammatory reactions.

Allergy as inflammatory reactions.


Fractionation of Sindbis virus by equilibrium centrifugation.


Pathology of carbohydrate metabolism in virus-infected cell cultures. II. Permeability of cell and mitochondrial membranes of chick embryo cells infected with mumps and vaccinia viruses.


Physical and biological properties of deae-dextran--polyriboinosinic: polyribocytidylic acid complexes.


Antigenic relationship between varicella-herpes zoster and herpes simplex viruses studied by the gel precipitation reaction.


Distribution of attenuated vaccine strains of pseudorabies virus in intraperitoneally infected swine foetuses.


Aëdes aegypti mosquitoes as an experimental model for studies on the ecology and genetics of Venezuelan equine encephalomyelitis virus.


Thermosensitivity of Tahyna virus.

Thermosensitivity of Tahyna virus.


Comparative studies on the properties of variola virus strains. II. Pathogenicity for suckling mice and gamma-irradiated adult white mice.


Efficient purification procedure for red clover mottle virus.


Infection of chicks with Venezuelan equine encephalomyelitis virus.


Inhibition of virus multiplication by selected isothiocyanates.


Inhibition of virus multiplication by some derivatives of pyridine- and pyrazinecarboxylic acid.


Isolation in south-west Ukraine of viruses of the Uukuniemi group.


Transmission of tick-borne encephalitis (TBE) virus by Dermacentor marginatus and D. reticulatus ticks.


Diagnosis and certain biological properties of the virus of Marek's disease.


Antibodies to arboviruses in birds in Czechoslovakia.


Experimental cardiac arrhythmias in the evaluation of anti-arrhythmic drugs.


Metabolism of  35 S-sulphate and properties of APS-kinase and PAPS-reductase in Nitrobacter agilis.


An inhospital program for rehabilitation of patients with chronic obstructive pulmonary disease.


Five psychological measures of neurotic depression: a correlation study.


Determination of phenothiazine compounds in biologic specimens by UV spectrophotometry.


Free and bound water in crude drugs: effect of extraction method on subsequent analysis by GLC.


Functional diagnosis of the heart by the spatial T-area vector.


California group arboviruses in Florida. Host-vector relations.


Evaluating legal competency.

Evaluating legal competency.


Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.


Potentiation of AMP-aminohydrolase activity of brain mitochondria by hexokinase.


Triphosphopyridine nucleotide-dependent enzymes in the developing spinal cord of the rabbit.


Dental health status of preschool children from five Washtenaw County communities.


The influence of tyrosine, phenylpyruvate and vitamin B 6 upon seizure thresholds.


Correspondence. Propranolol.

Correspondence. Propranolol.


Multiple determinants of 17-hydroxycorticosteroid excretion in recruits during basic training.


Lipid peroxide formation in rat brain.

Lipid peroxide formation in rat brain.


The release in vivo of dopamine synthesized from labelled precursors in the caudate nucleus of the cat.


Salicylate-induced foetal damage late in pregnancy. An experimental study in mice.


Kinetic testing of drugs against Mycobacterium leprae in mice. Activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin.


Chikungunya virus infection and transmission in five species of mosquito.


An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene.


Cytochromes in bovine liver nuclear membranes.


Turnover of tyrosine transaminase in cultured hepatoma cells after inhibition of protein synthesis.


The inactivation of chick tyrosine aminotransferase by acid and alkaline phosphatases.


A comparative study of aversion relief and systematic desensitization in the treatment of phobias.


Effectiveness of drug therapy in hypertension: present status. A review.


Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.


Conversion of the alpha-hydroxy and alpha-keto analogues of methionine to methionine by cell-free extracts of adult female Ascaris suum.


Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.


Anticonvulsant drugs in idiopathic epilepsy.


Ampicillin and kanamycin concentrations in joint fluid.


Evaluation of tranquillisers with subnormal patients. 3. Behavioural changes.


Hemodynamics of the carotid sinus reflex elicited by bilateral carotid occlusion in the conscious dog. Effect of  - or  -adrenergic blockade on the reflex response.


A curricular experiment with the nurse pediatrist.


Anticipated patient acceptance of new nursing roles and physicians' assistants.


The Community Health Medic Physician-Assistant Training Program.


Oxidation of cholesterol, 3 -hydroxy-5-pregnen-20-one and 3 -hydroxy-5-androsten-17-one by rat liver microsomes.


Synchronous activation of the alleles coding for the S-form of the NADP-dependent malate dehydrogenase during mouse embryogenesis.


The view box.

The view box.


Physicians + organized medicine = action.


Toward the rational use of digoxin.

Toward the rational use of digoxin.


EKG of the month.

EKG of the month.


Long term fate of arterial homograft.

Long term fate of arterial homograft.


Obesity. A much neglected public health problem.


Method of peer review for cancer cure.

Method of peer review for cancer cure.


File it and find it.

File it and find it.


Disposable vs. cloth surgical drapes.

Disposable vs. cloth surgical drapes.


Eat what you like.

Eat what you like.


Quo Vadis, M.D.

Quo Vadis, M.D.


Mechanism of bronchoconstriction due to beta adrenergic blockade. Studies with practolol, propranolol, and atropine.


Physician's assistants in Florida.

Physician's assistants in Florida.


Efforts so far.

Efforts so far.


The physician's assistant. A blessing or a curse?


Physician's assistants in radiology.

Physician's assistants in radiology.


Dr. Jekyll or Mr. Hyde.

Dr. Jekyll or Mr. Hyde.


Physician's assistants. The three types.


The physician's assistant--who needs him.


Lack of antibody activity in human myeloma proteins.


The influence of transfusions from unrelated donors upon marrow grafts between histocompatible canine siblings.


Beta adrenergic blocking and cardiovascular properties of two new substances, Kö 1313 and Kö 1366.


Effects of oxprenolol on coronary circulation and cardiac metabolism.


Effect of ethacrynic acid on hindlimb vascular resistance of anephric dogs.


Studies on the nonspecific blocking action of benzyltrimethylammonium bromide (BTM).


A comparison of the effects of halothane and CCl 4  on the hepatic drug metabolizing system.


Daunorubicin metabolism by rat tissue preparations.


Intensive care of the trauma patient.

Intensive care of the trauma patient.


Bovine adrenal glucose-6-phosphate dehydrogenase. 3. Control of the activity by ascorbate, substrates, and hydrophobic molecules.


Isolation and structure of hypothalamic MSH release-inhibition hormone.


Electroencephalographic seizure activity in dogs during anaesthesia.


Role of ventilation and blood flow in pulmonary clearance of inhalation anaesthetics. A theoretical study.


Hemodynamic effects of oxprenolol and practolol during halothane anesthesia.


Further evidence for 'active' reflex vasodilation.


Oxidative metabolism of leukocytes from nondiabetic and diabetic patients.


Biochemical characterization of Kupffer and parenchymal cells isolated from rat liver.


Salem dental survey--1971.

Salem dental survey--1971.


Cardiopulmonary effects of antimalarial drugs. V. Cycloguanil and a new triazine compound (WR 99,662).


Noradrenergic mediation of experimental cerebrovascular spasm.


The hysterical character in psychoanalytic theory. Evolution and confusion.


Fatty acid synthesis from pyruvate in white adipose tissue: the effect of norepinephrine.


6-Methylsalicylic acid synthesis by isolated barley chloroplasts.


The cholesterol side-chain cleavage enzyme system in mitochondria of human term placenta.


Hemodynamic effects of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956): a nonadrenergic myocardial stimulant.


Inability of substrates to alter the carbon monoxide and ethyl isocyanide difference spectra of microsomal hemoprotein.


Effect of 4-(2-hydroxy-3-isopropylaminopropoxy) acetanilide (AY 21,011) on the myocardial and coronary vascular responses to adrenergic stimulation.


Some cardiovascular and autonomic effects of fenfluramine hydrochloride.


A bilaterally cryptorchid springbok ram, Antidorcas marsupialis marsupialis.


Tooth transplantation in the mouse. II. The role of the histocompatibility-2 (H-2) system in tooth germ transplantation.


Oxygen consumption by seminiferous tubules and interstitial tissues of normal and cryptorchid rat testes.


Studies on the correlation between dental caries and the presence of Candida in the oral cavity of children.


Studies on the symmetry of dental caries in schoolchildren.


The effects of disodium etidronate on the reproductive functions and embryogeny of albino rats and New Zealand rabbits.


Human placental hydroxylation of 3,4-benzpyrene during early gestation and at term.


The cardiovascular actions of ellipticine.


Electron transport in sarcoplasmic reticulum of fast and slow muscles.


Delayed onset of encephalitis in mice passively immunised against Semliki Forest virus.


The nature of experimental second-set kidney transplant rejection. 4. The disturbed haemodynamics and the general significance of failure to perfuse the outer cortical glomeruli in acute renal failure.


Some psychosomatic aspects of neoplasia.


Risk-taking and arousal regulation.

Risk-taking and arousal regulation.


Effect of hypophysectomy on liver enzymes in the chicken, Gallus domesticus: replacement therapy with growth hormone and thyroxine.


Effect of hypophysectomy on some enzymes involved in lipid metabolism of the domestic chicken (Gallus domesticus).


Immunocompetent cell functions in mice infected with Friend leukemia virus.


Structure-activity relations for anticholinergic 2(1-aryl(or cyclohexyl)-1-hydroxy-1-phenyl)methyl-1,3-dioxolans.


The ganglion blocking activity of diastereoisomeric dimethylaminobornyl acetates and their methiodides.


Correlation of the recovery of the granular uptake-storage mechanism and the nerve impulse induced release of ( 3 H)noradrenaline after reserpine.


The polymorphism of sulphathiazole.

The polymorphism of sulphathiazole.


The reversal of experimental cardiac arrhythmias by indoramin (Wy 21901).


Methods for the preparation of lysophosphatidylcholine.


The effect of suspensions on the bactericidal activity of m-cresol and benzalkonium chloride.


Interference of chemoluminescence with ( 3 H)scintillation counting.


A comparison of adrenergic alpha-receptors by the use of NN-dimethyl-2-bromo-2-phenylethylamine (DMPEA).


Nikethamide and doxapram effects on pentazocine- and morphine-induced respiratory depression.


Antagonism of (+)-amphetamine-induced hyperthermia in rats by pimozide.


Variation in hydroxytryptamine metabolism in the rat: effects on the neurochemical response to phencyclidine.


On the mechanism of papaverine action on the control of vascular smooth muscle contractile activity by extracellular calcium.


Physical performance of mice treated with propranolol, sotalol and INPEA.


Inhibition of (+)-amphetamine hyperthermia by blockade of dopamine receptors in rabbits.


The fluorimetric determination of thymoxamine in plasma.


Reversal by sotalol of the respiratory depression induced in mice by ethanol.


Experimental gastric ulcers and uropepsinogen excretion in the rat.


The effect of amantadine on spontaneous locomotor activity in the rat.


Urinary histamine and urine volume in man.


An automated method for the determination of dissolution rate and urinary concentration of sulphonamides.


Help for the physician--physician assistant.


A strategy for health manpower. Reflections on an experience called MEDEX.


The syniatrist. A suggested nomenclature and classification for allied health professionals.


Comparison of the immunosuppressive effect of IgG and IgM fractions of rabbit anti-mouse thymocyte serum.


Observations on the feeding habits of some mosquitoes in Gunma Prefecture, Japan.


Cytochrome P450 and steroid 21-hydroxylation in microsomes from human adrenal cortex.


Mechanism of activation and deactivation of Dyfonate (o-ethyl S-phenyl ethylphosphonodithioate) by rat liver microsomes.


Renal allotransplantation in humans. Collective review and case reports.


Penicillin allergy. A review of the immunological and clinical aspects.


Feedback about interpersonal behavior as an agent of behavior change: a case study in the treatment of depression.


Cellular components specifically labeled during sorbose stimulation of sugar transport in neurospora.


Evidence of the participation of deoxycholate in cancer immunity.


Antibodies to chlorophyll and their reactions with chloroplast preparations.


Dielectric studies of aggregation phenomena with separated alpha and beta chains of human hemoglobin.


A simple method of preparation of labelled peptides possessing antibiotic properties.


Flash photolysis of rhodopsin. I. Measurements on bovine rod outer segments.


Effect of practolol on exercise tolerance in patients with angina pectoris.


Roentgenologic-pathologic evaluation of rejection in allografted lungs.


I. Prevalence of extrachromosomal drug resistance. Changes in asusceptibility of selected pathogenic bacteria to widely used antibiotics.


Evidence for a covalent linkage between heteropolysaccharide and an hydroxy proline-containing peptide from Metridium dianthus connective tissue.


Investigation of the component reactions of oxidative demethylation of sterols. Metabolism of 4 -hydroxymethyl steroids.


Synthesis and uptake of 5-hydroxytryptamine by the myenteric plexus of the guinea-pig ileum. A histochemical study.


Development of cyclophosphamide activation and its implications in perinatal toxicity to mice.


Activation of parathion and guthion by mammalian, avian, and piscine liver homogenates and cell fractions.


Graft-versus-host activity of rat bone marrow, marrow fractions, and lymphoid tissues quantitated by a popliteal lymph node weight assay.


The effect of antilymphocytic antibody on the primary immune response of mice to sheep erythrocytes, bovine serum albumin, and type 3 pneumococcus polysaccharide.


Toxicologic studies of glycopyrrolate in combination with other drugs.


Decrease in reduced glutathione and NADPH and inhibition of glucose-6-phosphate dehydrogenase activity caused by metabolites of fluroxene and halothane.


Drug metabolism in man: past, present, and future.


A review of current advances in metabolism of inhalation anesthetics.


The role of microsomes in the hepatic metabolism of ethanol.


Factors affecting drug metabolism.

Factors affecting drug metabolism.


The antihistaminic and anticholinergic activities of optically active diphenhydramine derivatives. The concept of complementarity.


Evidence for a different CO-binding pigment in solubilized rat hepatic microsomes.


Comparison of the effects of menadione and 2,3-dimethylnaphthoquinone on the energy-coupling reactions of beef-heart mitochondria. Evidence for the involvement of a thiol group in the reactions of oxidative phosphorylation.


4,4,6-trimethyl-3,4-dihydropyrimidine-2-thiol, an effective inhibitor of dopamine-beta-hydroxylation in vivo.


Enzymatic reduction of niridazole by rat liver microsomes.


Oxidation of cycloalkenes in liver microsomes.


Reduction of niridazole by rat liver santhine oxidase.


Some approaches to psychosomatic clinical research.


Virologic studies in rheumatoid arthritis and other connective tissue diseases.


Vasculitis in association with Australia antigen.


The relationship between the inhibition of dopamine uptake and the enhancement of amphetamine stereotypy.


Modification of the antinociceptive action of aminopyrine by an  -adrenergic blocking agent (phentolamine) and 2  -adrenergic blocking drugs (propranolol, oxoprenolol).


Personality (MMPI) and cognitive (WAIS) changes after levodopa treatment.


On the electron donating properties of the major tranquilizers.


Generalized hyperhidrosis following epilepsy.


Conversion of oleic acid into threo-dihydroxystearic acid by rat liver microsomes.


Activation of slaframine by liver microsomes and flavins.


Immune complex diseases.

Immune complex diseases.


Inter-relations of folic acid and vitamin B 12  in drug-treated epileptic patients.


Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.


Vasoconstriction produced in the iris-ciliary body of the cat eye by stimulation of local ganglion-like receptors.


Transketolase and myelin.

Transketolase and myelin.


The cause and prevention of postoperative intraperitoneal adhesions. This literature review attempts to enumerate possible etiologies of postoperative peritoneal adhesions as well as to suggest preventitive measures.  The theory that the cause of adhesions was development of fibrous tissue resulting from the destruction of serosa at surgery is discussed, but the author points out that numerous experimental and clinical experiences point to a more complicated etiology.  Serosal defects do heal, and not necessarily through adhesion formation, as shown in experimental animals; therefore a new notion of the process of peritoneal repair was advanced which, simply stated, sees free-floating macrophages as the principal source of new serosa.  So other areas and tissue types are probably the source of adhesions.  The discussion of these other etiological factors include ischemic tissue as a source of adhesions and foreign body causes of granuloma and adhesions (primarily surgical glove powder).  In terms of adhesion prevention, many approaches have been tried from using prophylactic agents to inhibit the formation of fibrin in peritoneal exudate (agents such as sodium citrate, heparin, and anticoagulants), use of enzymes and fibrinolytic agents, such as streptokinase and hyaluronidase, to introduction of inert polysiloxanes for prevention at the time of surgery.  The use of cortisone, which has been reported to have good results, is also discussed.  Finally, the control of distribution of adhesions by plicative techniques is enumerated.  With the up-to-date knowledge that adhesions which develop after abdominal operations represent a vascular response by surrounding structures to the stimulus of ischemic tissue or foreign material within the peritoneal cavity, rather than a healing mechanism for serosal defects, a rational approach toward operating on adhesions is presented; this technique requires scrupulous surgical procedure, freedom from foreign body intrusion, the leaving open of serosal defects (rather than pulling together under tension), and, frequently, attempts to surgically ensure that the inevitable adhesion formation occurs in areas which are innocuous to adjacent structures.


Fundamentals of the treatment of asthma.


Ocular toxin of the pneumococcus.

Ocular toxin of the pneumococcus.


Levodopa's awakening effect on patients with Parkinsonism. The effects of levodopa on tests measuring auditory and visual perception, auditory, and visual short-term memory, verbal learning, and on attention and concentration were studied in 29 patients with Parkinsonism. Thirty-two control subjects matched with the Parkinsonism patients on age, educational level, and verbal IQ were administered the same tests to control for practice effects. Significant improvement occurred for the Parkinsonism patients in verbal learning (an intermediate memory test) and in auditory perception. These improvements were unrelated to changes in anticholinergic medications, increases in alertness or concentration, lessening of depression, or improved motor ability or control. There was no test evidence of levodopa improving visual perception, short-term auditory or visual memory, alertness or concentration. Thus, there is no objective test evidence for levodopa producing a generalized awakening or an alerting effect in Parkinsonism patients who are intellectually alert and well-orientated. Interpretation of the test findings suggests a specific awakening effect, that of improvement in intermediate memory but not in short-term memory. Overall, the Parkinsonism group scored below the control group on all tests, suggesting that cognitive impairment accompanies Parkinson's disease even in patients who are intellectually intact and well oriented.


The medical manpower shortage.

The medical manpower shortage.


Acute controlled hypotension and EEG in patients with hypertension and cerebrovascular disease. Forty-seven patients with hypertension and/or cerebrovascular disease were examined by an acute controlled hypotension test. This was performed by intravenous administration of the ganglionic blocking agent pentholonium and head-up tilting on a pivoted table with observation of the clinical neurological state and simultaneous EEG recording. Blood pressure was reduced by approximately 55% and brought to the point where signs of general cerebral ischaemia developed. By tilting back to horizontal the blood pressure returned to near the normal level. No change in focal neurological symptoms or changes in the EEG were observed, and it is concluded that the majority of hypertensive patients with or without previous stroke do tolerate normalization of their blood pressure. Controlled hypotension with tilting seems a simple and valuable test for excluding those few subjects who might not tolerate a blood pressure reduction. Whether EEG monitoring during the test increases the value of the test has not been answered.


Mode of activation of granule-bound NADPH oxidase in leucocytes during phagocytosis.


Interaction of toxic venoms with the complement system.


Screening method for detection of drugs of abuse in human urine.


ACS/NIH organ transplant registry. First scientific report.


Antigenic competition in vitro of spleen cells subjected to a graft-versus-host reaction.


Theoretical considerations of alpha and beta adrenergic activity.


Effect of cycloheximide on the mixed-function oxidase system of cat liver.


Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.


Metabolism of the volatile anesthetics.

Metabolism of the volatile anesthetics.


Enzymes of amino acid metabolism in Dictyostelium discolideum. I. Tyrosine transaminase.


The bacteriology of chronic bronchitis.

The bacteriology of chronic bronchitis.


Unique beta adrenergic stimulation and blockade by quinterenol.


Oxidative drug metabolism in human liver microsomes.


Morphine-induced fetal malformations. II. Influence of histamine and diphenhydramine.


Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. 3. Studies on the average avidity of the antibody produced by specific plaque-forming cells.


New concepts on the epidemiological features of bovine besnoitiosis as determined by laboratory and field investigations.


Stimulation of new bone formation on intact bones by decalcified allogeneic bone matrix.


Cryptorchism: effect on pituitary gonadotropin secretion in the rat.


A career ladder in nursing. Problems and prospects.


Anatomical and chemical studies of a nigro-neostriatal projection in the cat.


Structure and chemistry of glucose-producing cells in meningeal tissue of the lamprey.


On the requirement for calcium during the steroidogenic effect of ACTH.


Effects of pinealectomy on the testicular function of the adult male duck.


The use of a recording microdensitometer for the quantitative measurement of enzyme activities inside tissue sections.


Determination of cell flow in an impaired condition of growth zone in hydra.


Per os transmission of Chilo iridescent virus to mosquitoes.


Studies on some physico-chemical properties of DNA isolated from fresh-water sponge, Ephydatia meyeni.


Inhibition of glyceraldehyde-3-phosphate dehydrogenase in mammalian nerve by iodoacetic acid.


Tissue specificity and systematics of a Nosema in some species of Aedes, Anopheles, and Culex.


Personality characteristics of alcoholics in relation to age and intelligence.


The MMPI in differentiating early multiple sclerosis and conversion hysteria.


MMPI social introversion-extroversion and hypnotic previous existence fantasies.


Validation of Gilberstadt and Duker's 8-6 profile type on a black sample.


Lymphography in systemic lupus erythematosus.


Pharmacological studies on the stereoselective antihistaminic and anticholinergic properties of L(S)- and D(R)-3-ethylamino-1-phenylpyrrolidine.


The effect of racemic propranolol, dextro-propranolol and racemic practolol on the human and canine cardiac transmembrane action potential (beta blockade and the cardiac action potential).


The effect of beta-adrenergic blockade on coronary blood flow in the homografted canine heart.


Effects of cyclic AMP, sympathomimetic amines, and adrenergic receptor antagonists on renin secretion.


'Metabolic' neuropathies and myopathies in infancy and childhood.


Drugs and motor functions.

Drugs and motor functions.


Polyarteritis nodosa of infancy. Fatal late complication.


[Cryopathies of the skin].

[Cryopathies of the skin].


Role of reduced TPN in the response to interstitial cell stimulating hormone.


Activity of NADH- and NADPH-dependent methemoglobin reductases in erythrocytes from fetal to adult age. A parallel assessment.


Cytotoxic antibody for epithelial cells in human graft versus host disease.


Selective inhibition by streptovaricin of splenomegaly induced Rauscher leukaemia by virus.


Streptovaricins inhibit focus formation by MSV (MLV) complex.


Effect of cholecystokinin on histamine- and pentagastrin-stimulated acid secretion in conscious cats.


A comparison of the effects of partial surgical and partial chemical (CCl 4) hepatectomy on microsomal cytochrome b 5 and P 450 and oxidative N-demethylation.


Arboviruses isolated from mosquitoes collected in southeastern Iowa in 1966.


Autoimmune progesterone urticaria.

Autoimmune progesterone urticaria.


Antibody formation by spleen cells of immunologically tolerant mice stimulated with antigen-antibody complexes.


Comparability of study groups in clinical trials of caries preventive agents.


Comparison of caries experience in mentally retarded and normal children.


Comparative immunologic studies on fish and invertebrate collagens.


The continuous and simultaneous measurement of O2-consumption, rate of decarboxylation of 14C-substrates and the performance of spontaneously-beating isolated heart atria of guinea pigs.


Bacterial meningoencephalitis in rhesus monkeys: clinical and pathological features.


Adoptive transfer of tumour homograft immunity by lymph node cells undergoing graft-versus-host reaction.


The effect of some beta-adrenergic receptor blocking drugs on carbohydrate metabolism in mouse brain.


The pharmacist as a primary practitioner: a guarded view.


Succinate semialdehyde dehydrogenase of Rhodopseudomonas spheroides which is active with both NADP +  and NAD + .


Intraendothelial inclusions in kidneys of patients with systemic lupus erythematosus.


The interaction of brain stem adrenergic systems and 8th nerve stimulation on the spinal cord.


Increased incidence of inguinal hernia, hydrocele, and undescended testicle in males with cystic fibrosis.


Tranquillizing effects of propranolol demonstrated in rats.


"Home rule powers" may threaten physicians.


Billing under the new fee-splitting legislation.


Review of the clinical implications of the virus--autoimmune response.


The transplantation biology of mammalian gestation.


Adolescent nutrition.

Adolescent nutrition.


Amniography in the early diagnosis of molar pregnancy.


Evaluation of a rapid technique for detecting minor tranquilizers.


Cooperative gastro-camera study with intravenous innovar.


Lung tumor following mastectomy.

Lung tumor following mastectomy.


Issues in graduate education; training for education in teaching.


Mechanism of action of p-hydroxybenzoate hydroxylase from Pseudomonas putida. 3. The enzyme-substrate complex.


Issues in graduate education in nursing.


Issues in graduate education; preparation for clinical specialization.


A ferredoxin-linked sulfite reductase from Clostridium pasteurianum.


Graduate education: some basic issues.

Graduate education: some basic issues.


Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate in each of the two reductive steps catalyzed by beta-hydroxy-beta-methylglutaryl coenzyme A reductase.


Issues in graduate education; education of nurse administrators for complex settings.


Issues in graduate education; training for research.


Release of noradrenaline from the dog heart in situ after intravenous and intracoronary administration of 5-hydroxytryptamine.


Immunological reactions carried out at a liquid-solid interface.


Prevention of colchicine intoxication by catatoxic steroids.


Glucose assay systems: evaluation of a colorimetric hexokinase procedure.


Civil aeromedical standards for general-use aerospace transportation vehicles.


Practolol in hyperthyroid cardiac failure.


Strabismus.

Strabismus.


The effect of inhalation of halogenated anesthetics on rat liver mitochondrial function.


Time pattern of antileukemic effect of graft-versus-host reaction in mice.


International agreement on a microtechnique of platelet complement fixation (Pl. C fix.).


Catecholamine release during anaphylactic shock in guinea pigs.


A common pathogenesis for the lesions of graft-versus-host disease.


Graft-versus-host reactions in bone marrow transplantation.


Clinical experience with bone marrow transplantation: failure and success.


Review of bone marrow transplants at the Ontario Cancer Institute.


Marrow transplanation in man following cyclophosphamide.


Antilymphoid globulin in the therapy of secondary disease.


The hypothermic effect of eserine in the rat.


Elicitation and expression of transplantation immunity in the uterus.


Dimethyl sulfoxide, a reversible inactivator of receptor-effector systems in the isolated guinea-pig ileum.


A new quantitative GVH assay: simultaneous estimation of mitostatic and lymphotoxic effects of immunosuppressants.


Allogeneic bone marrow transplantation after elimination of immunocompetent cells by means of density gradient centrifugation.


The influence of adrenergic receptor-blocking agents, amphetamine, and 6-aminonicotinamide on thermoregulation.


Immune status of allogeneic radiation chimeras.


Passenger leukocytes and induction of allograft immunity.


Simple method of 24-hour spleen preservation: further studies relating to hemophilia.


Bone marrow transplantation.

Bone marrow transplantation.


Use of low doses of homozygous allogeneic bone marrow cells to induce tolerance with antilymphocyte serum (ALS): tolerance by intraorgan injection.


Tolerance to skin allografts by immunosuppressive "pulse" of methylhydrazine derivatives and antilymphocyte serum.


Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: dose and timing.


Studies on time-dependence of immunosuppressive effects of antilymphocyte serum in vivo and in vitro.


Allogenic nucleated cells as immunogen and target for plaque-forming cells in mice.


Enhanced antibody production to type III pneumococcal polysaccharide in mice treated with antilymphocyte serum: evidence for cellular regulatory mechanism of IgM antibody response.


Mode of action of antilymphocyte sra (ALS).


Lymphoid cells sensitized in vitro against allogeneic or syngeneic fibroblasts produce immune effects in vitro and in vivo.


Demonstration of thymic function in vitro.


Toxic effects produced in insects by organophosphorus compounds. This paper reviews the toxicity of organophosphorus compounds in relation to cholinesterase inhibition in insects. It covers anticholinesterase effects on different stages of the life cycle and the relationship between cholinesterase inhibition and lethality. Other effects of organophosphorus compounds, which may account for anomalies in insecticidal action, are also considered.


-D-glucose:NAD(P) oxidoreductase (1.1.1.47) activity in aqueous extracts from the stomach muscles of domestic birds.


Time pattern of the antileukemic effect of graft-versus-host reaction in mice.


Yeast glutathione reductase. I. Spectrophotometric and kinetic studies of its interaction with reduced nicotinamide adenine dinucleotide.


Allograft reactivity in chick embryos.

Allograft reactivity in chick embryos.


Is high blood pressure a psychosomatic disorder? A critical review of the evidence.


Yeast glutathione reductase. II. Interaction of oxidized and 2-electron reduced enzyme with reduced and oxidized nicotinamide adenine dinucleotide phosphate.


Effects of synergists on the metabolism and toxicity  of anticholinesterases. Insecticide synergists enhance insecticidal action through their ability to block the enzymatic detoxification of insecticides with which they are combined. The structure of the synergist is therefore determined by the nature of the insecticide and the critical biochemical pathway responsible for its degradation.Synergists can be broadly classified as either analogue synergists, whose structure closely resembles that of the insecticide they synergize, or inhibitors of microsomal oxidation. Metabolism of the phenyl methylcarbamates is effected largely by the microsomal enzymes. Consequently microsomal enzyme inhibitors, such as the methylenedioxyphenyl compounds, the aryloxyalkylamines, the thiocyanates, the propynyl aryl ethers, and the 1,2,3-benzothiadiazoles, are all effective carbamate synergists. The detoxification pathways of the organophosphates, however, are more complex and include hydrolysis, dealkylation, and carboxylesterase pathways as well as oxidation. Because phosphorothioates are activated by oxidation, their toxicity is often antagonized by oxidase inhibitors. The effectiveness of different synergists towards resistant strains of insects is likely to vary in a manner that reflects the critical metabolic pathway on which resistance depends.


Effect of length of starvation, refeeding, and 8-azaguanine on serum insulin and NADP-linked dehydrogenases of rat liver.


Intersexuality in the pig.

Intersexuality in the pig.


Primary glaucoma profile on the Minnesota Multiphasic Personality Inventory.


Some ophthalmological factors affecting the personality patterns in primary glaucoma patients as determined by the Minnesota Multiphasic Personality Inventory.


Characteristics of a bacteriocin derived from Streptococcus faecalis var. zymogenes antagonistic to Diplococcus peumoniae. A bacteriocin-producing strain of Streptococcus faecalis var. zymogenes (E-1) was isolated from clinical material (conjunctiva). The active substance differed from bacteriocins described by other investigators primarily in its spectrum of antibacterial activity, especially by its marked inhibition of Diplococcus pneumoniae. The E-1 bacteriocin also inhibited nonhemolytic strains of enterococci as well as one-third of the Viridans group of streptococcal strains investigated. The degree of inhibition, however, as indicated by the size of the zones against the latter organisms, was significantly reduced. No activity was detected against any of the strains belonging to the following groups of bacteria: hemolytic enterococci, beta-hemolytic streptococci, nonhemolytic streptococci, staphylococci, and various gram-negative species. Similarly, three strains each of Bacillus cereus and Listeria monocytogenes and one strain of Erysipelothrix insidiosa were not inhibited. The bacteriocin was able to diffuse through bacterial membranes as well as cellulose dialyzer tubing. It was inactivated by heating to 80 C for 20 min but resisted inactivation by either trypsin or chloroform.


Regenerative functions and microbial ecology of coral reefs. I. Assays for microbial population.


Regenerative functions and microbial ecology of coral reefs. II. Oxygen metabolism in the regenerative system.


Localization and persistence of metaraminol and  -methyl-m-tyramine in rat and rabbit brain.


The inhibition by methylmalonic acid of malate transport by the dicarboxylate carrier in rat liver mitochondria. A possible explantation for hypoglycemia in methylmalonic aciduria. We report the effects of methylmalonic acid (MMA) on the mitochondrial transport systems for malate, alpha-oxoglutarate, and isocitrate. MMA is shown to be a substrate for all three carrier systems, and an inhibitor of the malate-phosphate exchange carrier. The effects of MMA on the metabolism of malate, oxoglutarate, and isocitrate by rat liver mitochondria are demonstrated to be mediated by the influence of MMA on the transport step. A hypothesis regarding the metabolic impairments responsible for hypoglycemia and ketonemia in methylmalonic aciduria is formulated in relation to these findings.


The nature of the interaction of amines with the pancreatic beta cell to influence insulin secretion.


Further studies on the effects of metal ions on rat liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase.


An analysis of the uptake of 5-hydroxytryptamine by the myenteric plexus of the small intestine of the guinea pig.


A function for  -tocopherol: stabilization of the microsomal membrane from radical attack during TPNH-dependent oxidations.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 46-1971.


The adrenergic receptors in isolated rabbit stomach muscle.


Practical experience in peer review controlling quality in the delivery of dental care.


The effects of hydrocortisone on the immune response.


Physician's assistants in dermatology.

Physician's assistants in dermatology.


Cough in allergic respiratory disease.

Cough in allergic respiratory disease.


Immunofluorescence of cutaneous vasculitis associated with systemic disease.


The heterogeneity of personality among alcoholics.


A2 cell pancreatic microadenomas in a case of multiple endocrine adenomatosis.


Synthesis and degradation of glucose-6-phosphate dehydrogenase in the rat uterus.


Effects of sex hormones on three glucocorticoid-inducible enzymes concerned with amino acid metabolism in rat liver.


Personality patterns and alcohol abuse in a state hospital population.


Ecdysone-initiated ovarian development in mosquitoes.


Immunotherapy of cancer.

Immunotherapy of cancer.


Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity.


Rates of transmitter turnover in spinal monosynaptic pathway investigated by electrophysiological techniques.


Persistent changes in transmission in spinal monosynaptic pathway after prolonged tetanization.


The etiology of idiopathic epididymitis.


A pharmacological study of the alkaloids 1-canadine methochloride and d-tembetarine chloride.


Some properties of the junctional and extrajunctional receptors in the vas deferens of the guinea-pig.


The thymus humoral factor under scrutiny.


Psychiatric patients' responses to MMPI religion items.


A histochemical and electron microscopic study of epinephrine-induced myocardial necrosis.


Vagal non-adrenergic inhibition of guinea-pig stomach. 1. The effect of vagal and sympathetic stimulation on the mechanical and electrical activity (intracellular recording) of the body of the guinea-pig stomach was investigated in vitro.2. Following atropine, 1 x 10(-6)-1 x 10(-7) g/ml., vagal responses were reversed from excitatory to inhibitory.3. Sympathetic blockade, produced by alpha- and beta-receptor antagonists and adrenergic neurone-blocking agents, reduced or abolished sympathetic, but not vagal inhibition.4. Hexamethonium (5 x 10(-5) g/ml.) reduced vagal relaxation to 11-30% according to the stimulation rate. The residual response was maintained in the presence of 5-hydroxytryptamine tachyphylaxis.5. Many muscle cells were observed to be under the influence of both vagus and sympathetic nerves: the effect of sympathetic stimulation was always inhibitory in nature, but high stimulation rates were required. The effect of vagal stimulation was both excitatory and inhibitory even in the absence of atropine: low stimulation rates gave rise either to E.J.P.s (excitatory junctional potentials), often followed by spikes, or to I.J.P.s (inhibitory junctional potentials).6. In some spontaneously firing cells the interruption of electrical activity produced by vagal stimulation at 2/sec and sympathetic stimulation at 20/sec was recorded for a long enough time to check the effect of guanethedine (5 x 10(-6) g/ml.): the drug selectively blocked sympathetic inhibition.7. The significance of the inhibitory non-adrenergic transmitter, released by the intramural neurones activated by preganglionic vagal fibres, is discussed.


Inducing root end closure of traumatically injured permanent teeth.


Lethal midline granuloma. A review of the literature.


Antibody against Chikungunya virus in wild primates in Southern Africa.


The use of provocative skin tests and provocative nasal tests to predetermine therapeutic results in treatment of ragweed pollinosis.


Manpower shortage--fact or fancy?

Manpower shortage--fact or fancy?


Effects of dehydroepiandrosterone and its conjugates upon the activity of glucose-6-phosphate dehydrogenase. 3. Inhibition of glucose-6-phosphate dehydrogenase in human ovarian tissue.


Post-meiotic nuclear divisions in the oöcyst of Plasmodium berghei.


The adverse effects of a microsporidan on sporogony and infectivity of Plasmodium berghei.


Some effects of juvenile hormone mimics on Aedes aegypta and Rhodnius prolixus.


Anoxia in mosquito pupae under insoluble monolayers.


Infection of an Aedes albopictus cell line with an arbovirus isolated from anopheline mosquitoes.


Studies of the epidemiology of arthropod-borne virus infections at Mitchell River Mission, Cape York Peninsula, North Queensland. IV. Arbovirus infections of mosquitoes and mammals, 1967-1969.


Endeavour and reality. Reflections on the IVth International Congress on Pharmacology.


Selective effects of heterospecific antilymphocyte sera on graft and host components in graft-versus-host reactions.


The effect of prostaglandin E 1  and bradykinin on normal and depolarized isolated duodenum of the rat.


Resistance to picrotoxin poisoning induced by catatoxic steroids.


The effect of amphetamine and tyramine on the guinea-pig urinary bladder.


Experiments on the mechanism of action of caerulein at the level of the guinea-pig ileum and colon.


Prostaglandin E-1: a potential mediator of the inflammatory response.


Effect of caffeine on hepatic microsomal cytochrome P-450.


The rate-limiting step in aminopyrine demethylase of rat liver microsomes.


Patterns of drug use in the Haight-Ashbury neighborhood.


Death anxiety as related to depression and health of retired persons.


MMPI profiles of males with abnormal sex chromosome complements.


Some properties of a preparation of rat colon perfused in vitro through the vascular bed. 1. A technique is described for the perfusion of the isolated colon of the rat, involving the infusion of an appropriate fluid through both the inferior and the superior mesenteric arteries. During neither the preparation nor the subsequent perfusion is the colon without an adequate supply of oxygen. The preparation remains histologically intact and metabolically viable and is capable of actively transporting ions for up to 5 hr.2. The addition of at least 3 g albumin/100 ml. perfusate is necessary to prevent the formation of large quantities of serosal exudate. With erythrocytes added to the vascular perfusate the preparation appears to be adequately oxygenated as judged by measurements of the rate of glycolysis. The mean rate of oxygen utilization over 4 hr is 9.2 +/- 0.3 (4) mumole. hr(-1).g(-1) fat free dry weight.3. Ion transport rates approaching those found in vivo are found only after the administration of an antihistamine substance to the colon donor rat before operation. In the absence of an antihistamine substance there appears to be an ultrafiltration of the plasma fluid into the lumen.4. Vasodilatory substances accumulate in the recycled perfusate. In a ;single pass' perfusion, the transport capacity of the preparation decreases at high perfusion pressures. It is suggested that this is due to some form of autoregulation whereby perfusate is shunted away from the epithelium into deeper layers as the pressure is increased.5. With CO(2) absent from the vascular infusate there is an increase in the net lumen to blood flux of total CO(2). This increased flux is accompanied by an equivalent amount of cation, comprising Na(+) and K(+) in the ratio of 12:1.6. The presence of ammonium in the lumen, a physiological constituent of the contents of rat distal colon in vivo, has a marked inhibitory effect upon the secretion of CO(2) into the contents of the lumen of the colon.


Erythropoiesis in mice with graft-versus-host reaction:  59 Fe distribution in normal and x-irradiated mice and mice with graft-versus-host reaction.


The effect of adrenaline and noradrenaline on the blood flow, electrical conductance and external secretion of the pancreas. 1. Adrenaline and noradrenaline cause a biphasic change in the transverse electrical conductance across the cat pancreas. After a latent period of from 5 to 30 sec a phase of decreased conductance lasting about 30 sec occurs which gives way to a phase of increased conductance lasting from 5 to 8 min.2. Coincidentally with the phase of decreased conductance, vasoconstriction and a reduction in blood flow occurs and an increased blood flow with the phase of increased conductance. The blood flow and conductance records run a parallel time course.3. Weight for weight adrenaline produces changes of greater magnitude than noradrenaline.4. The phase of decreased conductance and blood flow was abolished by an alpha-receptor blocking agent and the phase of increased conductance and blood flow by a combination of alpha- and beta-receptor blocking agents.5. Inhibition of the volume rate of secretion coincident with the phase of decreased conductance followed rapid intravenous injection of adrenaline or noradrenaline. During the phase of increased conductance secretion either returned to control values or was transiently augmented.6. Inhibition of secretion occurred after alpha-receptor blockade in the absence of vasoconstriction, suggesting that the catecholamines have a direct action on the cell.7. beta-receptor blockade increased the effectiveness of adrenaline to inhibit pancreatic secretion. When the effects of the catecholamines on secretion were tested, secretion was always induced by secretin.


Bacteria and serologic reactions against bacteria in patients hospitalized with acute respiratory illness.


Toxic epidermal necrolysis (Leyell's syndrome). A report on four cases with three deaths.


The biology of rodent malaria with particular reference to Plasmodium vinckei vinckei Rodhain 1952.


Studies on cellular and humoral immune factors in human renal transplantation.


Workshop on paediatric education. Xii. International Congress of Paediatrics, Mexico City, November 30, 1968: working document.


Report of stingings by the coelenterate Rhizophysa eysenhardti gegenbaur in California waters.


Treatment of sting ray wounds.

Treatment of sting ray wounds.


Human injuries from invertebrate animals in the Australian seas.


Report of stingings by the sea anemone Triactis producta Klunzinger from Red Sea.


Free-flow electrophoretic separation of lymphocytes. Separation of graft versus host reactive lymphocytes of rat spleens.


Antagonism of slow reacting substance by polyphloretin phosphate on isolated human bronchi.


Quantitative evaluation of release and reuptake of adrenergic transmitter in the rabbit heart.


Electrophysiological changes in humans during sensory isolation.


Measurement of tremor in the Makai Range 520-foot saturation dive.


Rotating vivarium concept for earth-like habitation in space.


Effect of mesuprine hydrochloride upon nonpregnant uterine contractility and the cardiovascular system.


The nonphysician as primary therapist in hospital psychiatry.


Abdominal compression: a valuable aid in the examination of the esophagus.


Equilibrium of the ATP: glutamine synthetase adenyltransferase reaction.


Inversion in the metabolism of D-tryptophan in the rabbit and the rat.


On the differential cytotoxicity of actinomycin D. Actinomycin D (AMD) at concentrations that inhibit cellular RNA synthesis by 85% or more causes an acute phase of lethal cell degeneration in HeLa cultures beginning as early as 3 hr after drug exposure, resulting in the nearly complete loss of viable cells by 12 hr. The loss of cells during this acute phase of lethality is closely dose dependent. Vero, WI38, or L cells are not susceptible to this early acute cyto-intoxication by AMD, and may begin to die only after 1-2 days. Differential susceptibility to acute cyto-intoxication by AMD, or other inhibitors of RNA synthesis (daunomycin or nogalamycin), among different types of cultured cells is analogous to that observed in vivo in certain tissues and tumors, and cannot be accounted for by differences in the effect of AMD on RNA, DNA, or protein syntheses, or by the over-all loss of preformed RNA. Actinomycin D in a dose that inhibits RNA synthesis causes an equivalent loss of the prelabeled RNA in all the cell types studied. Inhibition of protein synthesis with streptovitacin A or of DNA synthesis with hydroxyurea does not cause acute lethal injury in HeLa cells as does inhibition of RNA synthesis. Furthermore, since Vero or L cells divide at about the same rate as HeLa cells, no correlation can be drawn between the rate of cell proliferation and susceptibility to the cytotoxicity of AMD. Susceptibile cells are most vulnerable to intoxication by AMD in the G(1)-S interphase or early S phase. Inhibition of protein synthesis (which protects cells against damage by other agents affecting DNA) does not protect against AMD-induced injury. Although HeLa cells bind more AMD at a given dose than Vero or L cells, the latter cell types, given higher doses, can be made to bind proportionally more AMD without succumbing to acute cyto-intoxication. It is suggested that the differential susceptibility of these cell types to acute poisoning by AMD may reflect differences among various cells in the function or stability of certain RNA species not directly involved in translation whose presence is vital to cells. In HeLa cells, these critical species of RNA are presumed to have a short half-life.


Studies of absorption, excretion, antibacterial and clinical effect of cephalexin.


Immunologic aspects of renal transplantation.


Regulation of norepinephrine synthesis.

Regulation of norepinephrine synthesis.


The effect of pyrimidine analogues and tryptophan on enzyme synthesis and degradation in rat liver.


Enteric flora and mammalian enzyme induction.


Further studies on the induction of tyrosine aminotransferase in Morris hepatoma 9618A.


Immunologicc activity of the aged.

Immunologicc activity of the aged.


Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.


Metabolism of ethanol by rat liver microsomal enzymes.


Pharmacologic properties of anti-vertiginous drugs.


Reconstructive surgery of primary megalo-ureter.


A case of transverse testicular ectopia.


The influence of biographical anamnesis and group psychotherapy on postmyocardial patients.


Tolerance to, and dependence on, some non-opiate psychotropic drugs.


Natural and synthetic materials with insect hormone activity. 9. Structure- juvenile activity relationships in simple peptides.


Cell cycle analysis and stimulation of rat kangaroo cells (PtK 2 ) after pulse labeling.


Re-vascularisation of a free skin autograft.


The simple sociopath: physiologic and sociologic characteristics.


Physicians' assistants.

Physicians' assistants.


Urinary studies of schizophrenics and controls.


Meiosis in the male of Culex pipiens and Aedes albopictus and fertilization in the Culex pipiens-complex.


Etiologic factors in 1294 consecutive cases of male infertility.


On the role of separated gas in decompression procedures.


Structural and functional changes of frog neuromuscular junctions in high calcium solutions.


Studies on immunological paralysis. IV. The relative contributions of continuous antibody neutralization and central inhibition to paralysis with type 3 pneumococcal polysaccharide.


Drug inhibition of memory formation in chickens. II. Short-term memory.


Drug inhibition of memory formation in chickens. I. Long-term memory.


a model for collagen hydration.

a model for collagen hydration.