Studies on spermatogenesis in rats. V. Increased thermal lability of lysosomes from testicular germinal cells and its possible relationship to impairments in spermatogenesis in cryptorchidism.


Evidence for NADH- and NADPH-specific isozymes of glutamate dehydrogenase and the continuous inducibility of the NADPH-specific isozyme throughout the cell cycle of the eucaryote Chlorella.


Clinicopathological conference of the Medical University of South Carolina. "Progressive hypertension in 60-year-old man with hematuria, abdominal pain and fever".


The effect of phenobarbital on the synthesis of nascent protein on free and membrane-bound polyribosomes of normal and regenerating liver.


Eriochrome black, a means for reduction of nonspecificity in immunofluorescence.


Effect of a beta-adrenoceptor-stimulating compound (Terbutaline) on common bile duct pressure in man.


The dedifferentiated pattern of enzymes in livers of tumor-bearing rats.


Effects of derivatives of cyclic 3',5'-adenosine monophosphate on the growth, morphology, and gene expression of hepatoma cells in culture.


In vitro synthesis of noradrenaline in ganglia and salivary glands after in vivo preganglionic stimulation.


Genetically determined abnormalities of the reproductive system.


Tetracycline-resistant group A streptococci and pneumococci.


The biosynthesis of adrenocortical steroids.


Cephalexin therapy of lower respiratory tract, soft tissue and bone infections.


Oral and dental state in Helsinki preschool children. I. Caries of the deciduous dentition.


The energy metabolism of the thyroid gland.


Aequorin: its ionic specificity.

Aequorin: its ionic specificity.


Nicotinamide inhibition of 3',5'-cyclic AMP phosphodiesterase in vitro.


Presence of red cell type NADH-methemoglobin reductase (NADH-diaphorase) in human non erythroid cells.


Gas exchange in the lamprey, entosphenus tridentatus.


Cancer immunotherapy with HLA-compatible thoracic duct lymphocyte transplantation. A preliminary report.


Testosterone-induced development of limb gills of the lungfish, Lepidosiren paradoxa.


Effects of vagal stimulation on the pacemaker action potentials of carp heart.


Specificity characteristics in the intestinal absorption of model amino acids in domestic fowl.


The effect of preloaded amino acids on lysine and homoarginine transport in chicken small intestine.


85 Sr- 45 Ca discrimination by the active shell gland of the fowl.


Normal buffer lines for oxygenated and deoxygenated blood of the laying hen.


Volume changes of cerebrospinal fluid in Squalus acanthias during carbonic anhydrase inhibition.


Studies on anaerobic metabolism in the fresh-water turtle (Pseudemys scripta elegans).


Sensitivity of the receptors for salt-gland secretion in the domestic duck and goose.


Electrophysiological studies of the effects of sympathetic nerve stimulation and hormones on uterine motility.


Incorporation of dietary nitrogen into microbial nitrogen in the forestomach of the Kangaroo Island wallaby Protemnodon eugenii (Desmarest).


Interrelationships between maternal and neonatal factors and thermoregulation in fasted neonatal swine (Sus domesticus).


The re-evaluation of a central nervous system stimulant: pipradrol hydrochloride.


The mark of an educated assistant.

The mark of an educated assistant.


Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse. The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed.


Rapid viral induction of murine lymphomas in the graft-versus-host reaction. When weanling (SJL/J x C57BL/1)F(1) hybrid mice were given five weekly-injections of small doses of viable SJL/J spleen cells, so as to induce a graft-versus-host reaction (GVHR), reticulum cell sarcomas were induced in all of the host mice by the 40th day after the first cell injection. Such tumors, on transplantation, were accepted by syngeneic (SJL/J x C57BL/1)F(1) and C57BL/1 hosts, but not by SJL/J or NZB mice. Cell-free extracts of SJL/J spleens injected into similar hybrids resulted in identical tumors in all hosts within the same period; the transplantation characteristics were also similar. Normal (SJL/J x C57BL/1)F(1) hybrids as well as similar hybrids injected with SJL/J liver or syngeneic F(1) spleen cells did not develop tumors. Cell-free preparations of eight tumors induced in F(1)'s by viable SLJ/J spleen cells were injected into newborn (C57BL/1 x A)F(1) and C57BL/1 mice: tumors were induced, with seven of eight tumor preparations, with a latent period of 33-49 days. Such tumors were lymphosarcomas, and, in the case of (C57BL/1 x A)F(1) hosts, further transplantation revealed that they were antigenically C57BL/1 tumors. These experiments provide conclusive evidence for a viral etiology of GVHR-induced tumors. Furthermore, tumor induction in the GVHR does not appear to depend specifically on an immunological mechanism but is most probably due to release or activation of a sufficient quantity of oncogenic virus within a certain time period in a highly susceptible host. Comparison with radiation induction of viral leukemia in mice revealed similarities in regard to optimal host age and the spacing of administration of the tumor-inducing agent. SJL/J mice carry a type C virus which causes a high incidence of spontaneous Hodgkin-like tumors by 1 yr of age; C57BL/1 mice do not develop lymphomas spontaneously but carry a latent leukemogenic virus. Their hybrid also has a low incidence of spontaneous lymphomas. Based on the results of these and previous experiments, the viruses of these strains of mice appear to be highly synergistic in tumor induction in the GVHR. The SJL/J virus is a powerful oncogenic agent. The C57BL/1 virus may be a helper virus to the SJL/J, but is a more powerful determinant of the antigenic composition of the induced tumors. This suggests that the virus of C57BL/1 mice, when activated, is capable of controlling the C57BL/1 genome. Because of the ease and rapidity of viral tumor induction, the SJL/J and C57BL/1 strains of mice, with their F(1) hybrid, should be useful for further study of the mechanisms controlling induction of such tumors.


Studies on normal and immune lymphocyte transfer reactions in guinea pigs, with special reference to the cellular contribution of the host. Using guinea pigs of strains 2 and 13 and their F(1) hybrids as experimental subjects, various lines of evidence have been obtained that in this species, as in all others tested, the only significant cellular antigens with which donor lymphocytes engage when normal and immune lymphocyte reactions are incited are radiosensitive leukocytes. Constitutive cells of the skin are unimportant. (a) The intensities of these reactions in irradiated subjects are dependent upon the peripheral leukocyte concentration. When this falls below a certain threshold no reactions are incitable. (b) Highly leukopenic animals are capable of developing immune lymphocyte transfer (ILT) reactions if normal lymphoid cells of their own genetic constitution are mixed with the putative attacking donor cells, as "supplementing antigen," before inoculation. (c) Radiation-chimeric strain 13 animals having F(1) hybrid leukocytes in their bloodstream give typical ILT reactions when challenged intradermally with strain 13 anti-2 node cells. Exposure of strain 2 animals to 600 R does not prevent their becoming actively immunized if, 24 hr later, they are injected intradermally with strain 13 lymphocytes. However, this sensitization, revealed by the host's capacity to give delayed hypersensitivity reactions, wanes as leukopenia progresses. On the basis of this and other findings it is argued that the flare-up stage of the NLT reaction in preirradiated hosts is mainly an expression of host sensitivity against the transferred alien cells. Two unexpected observations have been made in the course of this study: (a) F(1) hybrid animals developed what appeared to be a strong delayed hypersensitivity after intradermal inoculation with parental strain lymphoid cells or antigenic extracts prepared from them. (b) If strain 13 guinea pigs which had been sensitized against strain 2 tissue antigens by intradermal injection of lymphocytes 7 days beforehand were inoculated intravenously with strain 2 antigenic extract a significant proportion of the animals developed severe delayed necrotizing reactions, recall flares, at some or all of the healed skin inoculation sites.


Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation. The functional attributes of minor subpopulations of mouse thymus cells derived by bovine serum albumin density gradient centrifugation, cortisone treatment, or selective depletion by anti-TL or anti-theta treatment have been examined. A subpopulation derived in each fashion contains the cells required to evoke graft-versus-host reactions in neonatal F(1) hybrid recipients and to be stimulated by alloantigens in vitro in one-way mixed lymphocyte cultures and by phytohemagglutinin. The functions of this subpopulation are abrogated by treatment with anti-H-2 plus complement and by high concentrations of anti-theta. A tentative ordering of the various thymus cell subpopulations, on the basis of these and other data, is described.


Guanyl cyclase activity in Morris hepatomas. 7787, 7795, 7800 and 9618A-2.


Acyl-CoA synthetase activity associated with microsomal and mitochondrial contaminants of isolated rat liver nucleic.


Stimulation of stearoyl-CoA desaturase activity by sn-glycero-3-phosphate in mouse liver microsomes.


On the mechanism of malonyl-CoA independent fatty acid synthesis. II. Isolation, properties and subcellular location of trans-2,3-hexenoyl-CoA and trans-2,3-decenoyl-CoA reductase.


Degradation of steroids by intestinal bacteria. IV. The aromatisation of ring A.


Lymphocyte response to phytohaemagglutin in pregnancy.


Reproduction of freshly isolated and laboratory-maintained strains of human herpesvirus in cell cultures.


Transmission of herpesvirus along the trigeminal nerve in rabbits.


Evaluation of the Czechoslovak double-stranded RNA preparation as inducer of interferon in model experiments.


Inhibition of multiplication of mouse cells in culture by interferon preparations.


A new method of preparing diagnostic Q fever antigen.


Localization of tick-borne encephalitis virus in alveolar cells of salivary glands of Dermacentor marginatus and Haemaphysalis inermis ticks.


Isolation and properties of amantadine-resistant variants of influenza A virus.


The influence of cell-free extracts from Ehrlich ascitic carcinoma and Rous sarcoma on the action of antiviral inhibitors.


Activation of the complement system by interferon inducers.


Mammalian cells: normal and deficient in "excision" repair system.


Rapid injection therapy in children with intractable asthma: safety and technique.


Sodium ion movements and the spontaneous and electrically stimulated release of ( 3 H)GABA and ( 14 C)glutamic acid from rat cortical slices.


Some biochemical and behavioural correlates of a possible animal model of human hyperkinetic syndromes.


Graft-versus-host reactivity of lymphoid cells inhibited by anti-recognition structure serum.


Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to  -adrenergic agents. In an effort to better define the role of betaadrenergic blockade in human bronchial asthma, peripheral blood leukocytes and lymphocytes from individuals with this condition were studied for possible alterations in cyclic AMP metabolism. Using a previously described radioimmunoassay to measure cyclic AMP, cells from asthmatic subjects were shown to have a highly significant decrease in their cyclic AMP response to beta-adrenergic agents (isoproterenol, norepinephrine, and epinephrine) by comparison with normal control cells. The alteration in responsiveness was most marked at the time of severe active asthma and returned toward normal during periods of clinical remission. Evidence was presented to indicate that the reduced response in cells from asthmatic individuals was not due to marked alterations in the proportion of T and B lymphocytes. Five normal volunteers were treated with an oral bronchodilator preparation containing theophylline and ephedrine over a 2 wk period without a significant change in the lymphocyte cyclic AMP response. These results provide unambiguous evidence for altered adrenergic responsiveness in bronchial asthma and indicate that purified peripheral blood lymphocytes should be a suitable in vitro system for further elucidation of the abnormality. Despite the reduction in catecholamine responsiveness in the asthmatic population as a whole, major alterations were largely restricted to individuals with severe, chronic asthma. Conclusive evidence for beta-adrenergic blockade in individuals who have not had recent asthmatic symptoms was not obtained, casting some doubt on the theory that bronchial asthma is due to a congenital derangement of cyclic AMP metabolism. Moreover, transient episodes of bronchospasm were often accompanied by a normal cyclic AMP response indicating that episodes of asthma frequently occur in the absence of easily demonstrable adrenergic blockade.


Selective sensitivity of thymus-derived cells to phytohaemagglutinin in vitro.


Heterotransplantation of tumours. IX. Conditioning of the recipient-checking of the effectiveness of suppression in vitro.


Immunosuppression with thyminalkylamine (Ypenyl Spofa): effect on antibody plaque-forming spleen cells.


Host-tumour relationship. XXX. A failure to demonstrate a special hyaluronidase inhibitor in the blood serum of cancer patients.


The growth of children at different altitudes in Ethiopia.


Effects of beta receptor stimulation and blockade on A-V nodal and bundle branch conduction in the canine heart.


Effect of glycerol and glucose additions on lipogenesis from acetate in rat and cow mammary tissue.


Effect of allogeneic cell interaction on the primary immune response in vitro. Cell types involved in suppression and stimulation of antibody synthesis.


The occurrence of L-fucose (D-arabinose) dehydrogenase in selected vertebrate species.


Stereospecificity of some invertebrate lactic dehydrogenases.


Phospholipases of marine invertebrates. I. Distribution of phospholipase A.


Transhydrogenase and anaerobic phosphorylation in Hymenolepis diminuta mitochondria.


Leiner's disease and C5 deficiency.

Leiner's disease and C5 deficiency.


Student health program for migrant farmworkers and rural poor.


Treatment of autosomal recessive lymphopenic agammaglobulinemia by transplantation of matched allogeneic bone marrow.


Serum immunoglobulin levels in pulmonary allergic aspergillosis and certain other lung diseases, with special reference to immunoglobulin E.


Depression of free water clearance during pneumococcal bacteremia.


Antagonism of cardiac arrhythmias by beta-adrenoreceptor blocking agents.


Antihypertensive activity of four blocking agents in spontaneously hypertensive rats.


Effects of catecholamines and sympatholytics on the guinea-pig pulmonary circulation.


Systemic and coronary hemodynamic effects of pronethalol practolol, sotalol and D-propranolol.


A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol. 1. [3alpha-(3)H]Cholesta-7,9-dien-3beta-ol is converted in high yield into cholesterol by a 10000g(av.) supernatant fraction of rat liver homogenate. 2. Incubation of cholesta-7,9-dien-3beta-ol with [4-(3)H]NADPH and rat liver microsomal fractions under anaerobic conditions resulted in (3)H being incorporated into the 14alpha-position of cholest-7-en-3beta-ol. 3. Under anaerobic conditions in the absence of NADPH cholesta-7,9-dien-3beta-ol was isomerized into cholesta-8,14-dien-3beta-ol by rat liver microsomal fractions.


A comparison of the NADH oxidase electron transport systems of two obligately chemolithotrophic bacteria.


Ampicillin dosage and use of prednisolone in treatment of pneumonia: co-operative controlled trial. A controlled trial was carried out to investigate whether the rate of recovery from pneumonia treated with ampicillin is dose related. Sixty-three patients received 1 g ampicillin daily and 63 received 2 g ampicillin daily for seven or 14 days depending on the rate of response. Twenty patients in each of these groups received, in addition, 20 mg prednisolone daily for seven days. The treatment groups were comparable and the results of treatment were similar in the four groups. The only difference which was of statistical significance was that a larger proportion of patients receiving 1 g ampicillin daily became afebrile within one week. All the ampicillin rashes occurred in the patients receiving 2 g ampicillin daily with and without prednisolone. Ampicillin 1 g daily appears to be adequate dosage in the treatment of pneumonia, and the rate of recovery has not been shown to be accelerated by using 2 g. No deleterious effects were noted with additional prednisolone therapy and this appeared to increase the rate at which the patients became afebrile, although the figures were not statistically significant.


Poisoning as a complication of enuresis.


Ictal and interictal psychiatric manifestations in epilepsy: specific or non-specific? A critical review of some of the evidence.


Pharmacologic blockade of reflex vasodilation: peripheral actions of antihistamines.


International congress of midwives.

International congress of midwives.


Mechanism of anti-inflammatory activity of  -adrenoceptor blocking agents.


The effect of stimulants and depressants of reticuloendothelial activity on drug metabolism.


Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase.


Possible implication of glutathione reductase in haemolysis by the direct lytic factor of cobra venom (Naja naja).


Carotid body tumors--idiosyncracies.

Carotid body tumors--idiosyncracies.


Change in electrophoretic mobility of glucose-6-phosphate dehydrogenase with aging of erythrocytes.


Some effects of Escherichia coli endotoxin on the graft-versus-host reaction in mice.


Potentials of spleen, lymph node, and Peyer's patches to reconstitute lymphoid tissue and produce graft-versus-host reaction.


Genetic control of graft-versus-host competence.


Spotlight on continuing education.

Spotlight on continuing education.


Damage of the skin during the acute graft-versus-host reaction in mice.


Some effects of a partially purified lymphocyte-inhibiting factor from calf thymus.


The complement-binding and absorptive capacity of human white blood cells treated with neuraminidase.


Graft-versus-host disease induced by fetal thymus and liver cells.


Immunologically competent passenger cells in mouse skin.


Symposium on isoproterenol therapy in asthma.


Conversion of allyl alcohol into acrolein by rat liver. 1. Acrolein was detected in rat liver suspensions incubated in the presence of allyl alcohol and allyl formate. Acrolein was determined by condensation of the distilled aldehyde with semicarbazide, followed by spectrophotometric measurement of the semicarbazone at 257nm and identification by paper chromatography. 2. The transformation of allyl alcohol into acrolein occurred in the presence of NAD(+). Inhibitors of rat liver alcohol dehydrogenase inhibited the reaction. 3. It is suggested that the hepatotoxic actions of allyl alcohol and of allyl formate on rat liver are related to their conversion into acrolein.


Interrelationship and control of glucose metabolism and lipogenesis in isolated fat-cells. Effect of the amount of glucose uptake on the rates of the pentose phosphate cycle and of fatty acid synthesis. In order to study the quantitative relationship between fatty acid synthesis and pentose phosphate-cycle activity under different hormonal and dietary conditions affecting the extent of glucose uptake, cells isolated from rat epididymal adipose tissue were incubated in bicarbonate buffer containing [U-(14)C]-, [1-(14)C]- or [6-(14)C]-glucose. From the amount of glucose taken up, the production of lactate and pyruvate, and the incorporation of (14)C from differently labelled [(14)C]glucose into CO(2), fatty acids and glyceride glycerol, the rates of glucose metabolism via different pathways and the extent of lipogenesis under various experimental conditions were determined. The contribution of the pentose phosphate-cycle to glucose metabolism under normal conditions was calculated to be 8%. Starvation and re-feeding, and the presence of insulin, caused an enhancement of glucose uptake, pentose phosphate-cycle activity and fatty acid synthesis. Plots of both pentose phosphate-cycle activity and fatty acid synthesis versus glucose uptake revealed that the extent of glucose uptake, over a wide range, determines the rates of fatty acid synthesis and glucose metabolism via the pentose phosphate cycle. A balance of formation and production of nicotinamide nucleotides in the cytoplasm was established. The total amount of cytoplasmic NADH and NADPH formed was only in slight excess over the hydrogen equivalents required for the synthesis of fatty acids, glyceride glycerol and lactate. Except in cells from starved animals, the pentose phosphate cycle was found to provide only about 60% of the NADPH required for fatty acid synthesis. The results are discussed with respect to an overall control of the different metabolic and biosynthetic reactions in the fat-cells by the amount of glucose transported into the cell.


Interrelationship and control of glucose metabolism and lipogenesis in isolated fat-cells. Control of pentose phosphate-cycle activity by cellular requirement for reduced nicotinamide adenine dinucleotide phosphate. By using inhibitors and stimulators of different metabolic pathways the interdependence of the pentose phosphate cycle and lipogenesis in isolated fat-cells was studied. Rotenone, which is known to inhibit electron transport in the respiratory chain, blocked glucose breakdown at the site of pyruvate dehydrogenase. Consequently, because of the lack of acetyl-CoA, fatty acid synthesis was almost abolished. A concomitant decrease in pentose phosphate-cycle activity was observed. Phenazine methosulphate stimulated pentose phosphate-cycle activity about five- to ten-fold without a considerable effect on fatty acid synthesis. The influence of rotenone on both the pentose phosphate cycle and lipogenesis could be overcome by addition of phenazine methosulphate, indicating that rotenone has no direct effect on these pathways. The decreased rate of the pentose phosphate cycle in the presence of rotenone therefore has to be considered as a consequence of decreased fatty acid synthesis. The rate of glucose catabolism via the pentose phosphate cycle in adipocytes appears to be determined by the requirement of NADPH for lipogenesis. Treatment of cells with 6-aminonicotinamide caused an accumulation of 6-phosphogluconate, indicating an inhibition of 6-phosphogluconate dehydrogenase. The rate of glucose metabolism via the pentose phosphate cycle as well as the rate of fatty acid synthesis, however, was not affected by 6-aminonicotinamide treatment and could still be stimulated by addition of insulin. Since even in cells from starved animals, in which the pentose phosphate-cycle activity is extremely low, no accumulation of 6-phosphogluconate was observed, it is concluded that the control of this pathway is achieved by the rate of regeneration of NADP at the site of glucose 6-phosphate dehydrogenase.


Ring hydroxylation of di-t-butylhydroxytoluene by rat liver microsomal preparations. 3,5-Di-t-butylhydroxytoluene (compound I) was converted into 4-hydroperoxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (compound II), 4-hydroxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (compound III) and 2,6-di-t-butyl-4-hydroxymethylphenol (compound IV) by rat liver microsomal preparations in the presence of NADPH and air. The oxidation of compound (I) by m-chloroperbenzoic acid also produced the same compounds. These results suggest that hydroperoxide can be an intermediate in aromatic hydroxylation and that biological oxygenations resemble per-acid reactions.


Doping.

Doping.


Protective effects of B.W. 501 C 67 and B.W. 204 C 67 against lethal effects of exudates from burnt rat skin.


Effects of hexamethonium and other agents on noradrenaline output released by the sympathetic nerve stimulation in the isolated perfused rabbit's heart.


Pharmacological studies of Panax Ginseng root: pharmacological properties of a crude saponin fraction.


Effects of catecholamines on sympathetic evoked action potentials in the stellate ganglion of the cat.


The effects of caffeine and imidazole on the actions of beta- and alpha-adrenergic stimulants, papaverine and cyclic 3', 5'-AMP.


Exposure and surgical emphysema.

Exposure and surgical emphysema.


Personality pathology and student drug use: an empirical study.


Training physician's assistants.

Training physician's assistants.


Cone-shaped epiphyses in the distal phalanges. Case report of a child with anorchia.


TMA policy on physician's assistant.

TMA policy on physician's assistant.


Secondary disease in mice after in vitro exposure of hematopoietic cells to concanavalin A.


Electrochemically driven biochemical reactions. II. Carbon dioxide fixation by electrochemical reduction of NADP +  in chloroplast extracts.


Differential development of murine immunocompetence to transplantation antigens.


Immunocompetence following allogeneic bone marrow transplantation in man.


Kinetics of graft-versus-host splenomegaly in neonatal F 1  recipients of parental strain mouse lymph node cells and-or thymocytes.


The physician's assistant and the provision of health care.


Latin American experience related to the solution of rural health problems in the United States.


Methods for dissecting dry insects and insects preserved in fixative solutions or by refrigeration. The methods described in this paper for the dissection of dry and preserved insects have been used for several years on various species, mainly mosquitos. In the past, dry or partially dry mosquitos found in traps or in the laboratory had to be discarded. By softening these insects in a detergent solution, however, it is possible to make most observations in the same way as on fresh material. The preservation of insects in the dry state, in a fixative, or in the refrigerator after collection enables much larger samples to be studied; the whole of the material can be examined and the work can be done when time permits. In addition, material can be sent to central laboratories far from the place of collection, and infected insects can be kept in stock for teaching purposes.


Virus-associated immunopathology: animal models and implications for human disease. 1. Effects of viruses on the immune system, immune-complex diseases, and antibody-mediated immunologic injury. The tissue damage caused by virus infection has been traditionally explained by the ability of viruses to multiply in cells and thereby injure or destroy them. Recent evidence suggests, however, that lesions may also be caused by the host's immune response to viral antigens and that the immune system itself may be perturbed by some viruses. This memorandum reviews recent developments in viral immunopathology, with special reference to animal model systems, and indicates the possible relevance of the new concepts and techniques for certain diseases of man. Certain viruses, notably the leukaemia viruses and some of those causing persistent infections, depress the host's ability to mount an antibody response to antigens, while other viruses may enhance the antibody response. Cell-mediated immunity may also be depressed. Another immunopathological manifestation of virus infection is immune-complex disease. When viruses or their antigens persist in the circulation they combine with specific antibody, and the resulting complexes lodge in various sites, especially the kidney. Further combination with complement leads to the release of tissue-damaging substances. A third condition associated with virus infection is antibody-mediated immunologic injury. Both oncogenic and non-oncogenic viruses frequently induce new antigens on the surface of the cells they invade. When antibody attaches to these antigens in the presence of complement, the cells are destroyed.


Membrane proliferation and phosphatidylcholine synthesis in normal, preneoplastic, and neoplastic mammary gland tissues in C3H mice.


Effects of RNA and protein synthesis inhibitors on preinduced levels of rat uterine glucose-6-phosphate dehydrogenase.


The influence of bursectomy and thymectomy on the formation of alloantibodies affecting the skin graft in ducks.


Automobile injuries--the forgotten area of public health dentistry.


Clinical evaluation of stannous fluoride as an anticaries mouthrinse.


Infra-red spectroscopic identification of non-barbiturate sedatives.


Dental vitality tests and pulp status.

Dental vitality tests and pulp status.


Purification and comparison of glutamine synthetase from rat and chick livers.


Perinatal development of tertiary amine N-oxidation and NADPH cytochrome C reduction in rat liver microsomes.


Comparison of myocardial irritability of selected anesthetics.


The influence of age on transplantation immunity. Reactivity to normal lymphocyte transfer at different ages.


On the effect of barbital on Streptomyces mediterranei.


Post-steroid panniculitis with cerebral vascular and pulmonary complications--report of an autopsy case.


Neurophysiologic aspects: hypothalamic factors in the control of eating behavior.


Usual and unusual agranulocytosis during neuroleptic therapy.


Health services and nursing: changing patterns. 2.


The sedative action of several antihistaminics. Electroencephalographic and statistical studies.


The challenge of life. Biomedical progress and human values. Roche anniversary symposium. Biomedical frontiers.


Problems of resource allocation in United States medical care.


Cardiac rehabilitation: its potential in the early prevention of disability after myocardial infarction.


Enzymic and chemical transformations of the side chain of cephalosporin C.


Type distribution and antibiotic sensitivity of pneumococci from carriers in Kiriwina, Trobriand islands (New Guinea).


Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.


A student looks at the statewide nursing conference.


Health and schools.

Health and schools.


Nucleotide-dependent inactivation of RNA polymerase from Bacillus brevis. RNA polymerase has been purified from vegetative cells of Bacillus brevis and resolved into "core" enzyme and sigma factor. The purified enzyme is rapidly inactivated by incubation at low temperatures in the presence of 1-2 mM ATP, dATP, or NAD(+), while other nucleotides at this concentration have little or no effect. Inactivation is not accompanied by the incorporation of an adenylyl or phosphoryl moiety into RNA polymerase; nevertheless, it is essentially irreversible. DNA, high concentrations of glycerol, as well as low concentrations (1 mM) of orthophosphate protect RNA polymerase from the nucleotide-dependent inactivation.A similar inactivation of RNA polymerase in the presence of ATP is observed with crude preparations from Bacillus subtilis and Bacillus polymyxa. This phenomenon may represent a novel mode of regulation of transcription that does not involve a covalent modification of RNA polymerase or its interaction with other protein factors, but rather is due to a structural transition to an inactive form induced by small molecules.


Synthesis of inducible tyrosine aminotransferase in a cell-free extract from cultured hepatoma cells. A cell-free extract from cultured rat hepatoma cells is described that incorporates amino acids into chains of tyrosine aminotransferase that are identical, by several criteria, with tyrosine aminotransferase from rat liver. Extracts from steroid-induced cells are 6-to 10-times more active for tyrosine aminotransferase synthesis than extracts from uninduced cells, although the total incorporation rates are identical.


Synthesis of plastoquinone analogs and inhibition of photosynthetic and mammalian enzyme systems. New 5-hydroxy- and 5-chloro-6-alkyl-1,4-benzoquinones with one or two methyl groups on the nucleus were synthesized as potential antimetabolites of plastoquinones for biological research on photosynthetic and mammalian enzyme systems; the primary emphasis was on photosynthesis.2,3-Dimethyl-5-hydroxy-6-phytyl-1,4-benzoquinone completely inhibited in chloroplasts the water-dependent electron transport, but photosystem I was insensitive to this analog. The data are consistent with the interpretation that this analog inhibits electron transport in the chain prior to the site of electron donation from the ascorbate-dichlorophenolindophenol couple. Concentrations of 70 muM and 120 muM of this analog caused about 50 and 100% inhibition, respectively, of cyclic photophosphorylation.2,3-Dimethyl-5-hydroxy-6-phytyl-1,4-benzoquinone is a new type of inhibitor of photosynthetic electron transport that specifically inhibits the rate-limiting step between photosystems I and II. Structurally related analogs caused inhibitions in the range of 50-100% in chloroplasts. These analogs showed marginal inhibition in mitochondrial coenzyme Q(10)-oxidase systems from beef heart.


Mesovarial leiomyomas in rats in a chronic toxicity study of mesuprine hydrochloride.


Evidence for infectious etiologies in connective tissue disorders.


The role of an obstetric associate in a private obstetric practice.


Personality changes in the first year of psychiatric residency training.


Therapeutic abortion: a prospective study. II. The psychosomatic and psychological reactions of 75 women applying for a therapeutic abortion were compared with those of 33 women in the same state of pregnancy but not requesting an abortion.  The abortion applicants differed significantly from the control group on 8 of the 10 scales tested.  The abortion applicants had more prepregnancy health problems and more psychosomatic symptoms than the control group.  They also showed more fears for themselves and the baby, less desire for pregnancy, more irritability and tension, less maternal feeling, and more depression and withdrawal than the control group.  Parity was not as important in determining responses to the questionnaire as was the patients' abortion status.  Literature on the use of pregnancy research questionnaires is reviewed.  The possible transience of psychological compared to psychosomatic symptoms is suggested.


The use of antihistamines for the alleviation of urinary retention caused by psychotropic drugs.


Prolonged pregnancy a problem of declining placental function.


Diagnosis and treatment of common bleeding disorders.


Licensure and credentialing of health manpower.


Industry's response to nutritional challenges.


The future for long term care.

The future for long term care.


The view box.

The view box.


EKG of the month.

EKG of the month.


Maternal death study no. 9.

Maternal death study no. 9.


Venereal disease today. II. Syphilis.

Venereal disease today. II. Syphilis.


The injured posterior urethra.

The injured posterior urethra.


Measles high cause of death.

Measles high cause of death.


The care and feeding of a collection agency.


Enhancement of morphine analgesia by two new adrenergic  -receptor antagonists, Bunolol & H64-52.


NMR analysis of pharmaceuticals. 8. Determination of trimethadione in various dosage forms.


2-(Aminoethanesulfonylamino)thiazole and related compounds. I. Stability, absorption, excretion, and some pharmacological activities.


Clinical experiences with prindolol (Visken) in the therapy of hypertension.


Experimental basis of bone marrow transplantation.


Treatment of leukemia and aplastic anemia with histocompatible allogeneic bone marrow transplantation. A review.


Localization of calcium pump activity in smooth muscle. A microsomal fraction isolated from longitudinal smooth muscle of guinea pig ileum actively sequesters calcium ion in the presence of magnesium and adenosine triphosphate in a fashion previously described for microsomes of the rabbit aorta. This activity in guinea pig ileum appears to be associated primarily with the plasma membrane as is found in the red cell. By contrast the uptake of calcium in aortic smooth muscle appears to be associated to an appreciable extent with intracellular membranes, possibly analogous to the sarcoplasmic reticulum of skeletal muscle.


Molecular luminescence studies of flavins. II. Interactions involving the excited states.


Studies of reactions between flavins and quinones, mercaptans, and enolates.


Photochemically induced adduct formation with flavin in pyridine.


On the interaction of flavins with phosphine-derivatives.


Photo-addition reactions in the benzenoid subnucleus of flavoquinones.


Covalent intermediates in flavin-sensitized photodehydrogenation and photodecarboxylation.


pH-dependence, isotope effect and products of flavin-sensitized photodecarboxylation and photodehydrogenation.


Intermediates in the neutral photolysis of riboflavin.


Model studies on flavin-dependent carbonyl-activation: reduction of carbonyl compounds by flavohydroquinone.


Proton magnetic resonance studies of flavoquinone-metal complexes.


Circular dichroism, self interaction and side chain conformation of riboflavin and riboflavin analogues.


Nitroalkanes as reductive substrates for flavoprotein oxidases.


4a,5-Cycloaddiction reactions of acetylenic compounds at the flavoquinone nucleus as mechanisms of flavoprotein inhibitions.


Comparison of stopped flow and steady state kinetics in the reaction of D-amino-acid oxidase with  -chloroalanine.


Spectrophotometric studies on lysine monooxygenase, a flavoprotein.


Spin label studies on the flavoproteins lipoamide dehydrogenase and D-amino acid oxidase.


Comparative kinetics between matrix-bound lipoamide dehydrogenase and the free enzyme.


Oxygen reaction of 4-hydroxybenzoate monooxygenase.


Recent advances in the chemistry of covalently bound flavin coenzymes.


D- and L-6-hydroxynicotine oxidase, enantiozymes of Arthrobacter oxidans.


Some properties of formate dehydrogenase.


Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans.


Activation of soluble succinate dehydrogenase by reduction.


Sequence around the active center cystine of lipoamide dehydrogenase from pig heart, comparison with the E. coli enzyme.


Butyryl coenzyme A dehydrogenase: studies on the specificity of the formation of acyl coenzyme A complexes with long-wavelength absorption.


NADH dehydrogenases from Azotobacter vinelandii.


On the mechanism of adenylyl sulfate reductase for the sulfate-reducing bacterium, Desulfovibrio vulgaris.


The reduction of flavodoxin from Azotobacter vinelandii by pyruvate.


Flavin interaction in NADPH-sulfite reductase.


Flavodoxin from the sulfate reducing bacterium Desulfovibrio vulgaris. Its structure at 2.5 A resolution.


Amino acid sequences of Clostridium pasteurianum flavodoxin.


Metabolism of organophosphorus insecticides. XIV. Malathion breakdown by soil fungi.


Circadian rhythm of oxygen consumption in rat liver suspension culture: changes of pattern.


The structure of the network of the vessels of the carotid body of the cat and its evaluation by means of the scanning electron microscope.


A demographic survey of physicians in Arizona--1972.


Increased tyrosine hydroxylase activity of sympathetic ganglia cultured in the presence of dibutyryl cyclic AMP.


Determination of serum 5-nucleotidase by means of a NADH-linked reaction.


The origin of urinary p-hydroxyphenylpyruvate in a patient with hepatic cytosol tyrosine aminotransferase deficiency.


Toxicity from Lomotil. Accidental ingestion by a 22-month-old child.


Substances with potential for abuse by elementary and secondary school pupils. An informational reminder.


Properties of 1-isopropylamino-3-(4-indanoxy)-2-propanol (USVC 6524), an adrenergic  -receptor blocking agent.


Counterimmunoelectrophoresis for rapid diagnosis of meningitis due to Diplococcus pneumoniae.


The effect of catecholamines and adrenergic blocking agents on the calcium and glycogen content in the rat heart.


Role of metabolism in pathogenesis of bacteremia due to Diplococcus pneumoniae in rabbits.


Absolute configuration by asymmetric synthesis of  (+)-1-(4-acetamidophenoxy)-3-(isopropylamino)-propan-z-ol (practolol).


A new empirical automated MMPI interpretive program: 2-8 and 8-2 code types.


Studies on a new 1,5-benzothiazepine derivative (CRD-401). 3. Effects of optical isomers of CRD-401 on smooth muscle and other pharmacological properties.


Studies on the lability of lysosomal membranes in S. mansoni infection. I. Observations on normal liver.


Graft-versus-host activity of rat lymphocytes after sensitization in vitro.


Pharmacokinetic studies of practolol, a beta adrenergic antagonist, in man.


Inducibility of benzo( )pyrene hydroxylase in human skin by polycylic hydrocarbons.


Specific enzyme production in eukaryotic cells.


Phoenix House. Changes in psychopathological signs of resident drug addicts.


Follow-up after therapeutic abortion in early adolescence.


Paranoia and naivete. Coexisting traits in three patients.


Plasma dopamine- -hydroxylase activity. Elevation in man during cold pressor test and exercise.


Purification, properties and reconstitutive activity of a DPHN dehydrogenase.


Muscle phosphofructokinase deficiency.

Muscle phosphofructokinase deficiency.


Microsomal ethanol-oxidizing system (MEOS): purification and properties of a rat liver system free of catalase and alcohol dehydrogenase.


Evaluation of the Hill coefficient for allosteric inhibitors.


Enzymic redox reactions of cytochromes c.


On the convulsive action of castrix.

On the convulsive action of castrix.


The effect of chewing gum on the incidence of dental diseases in Greek children. A 3-year study.


Biological effects of the adjuvant Corynebacterium parvum. I. Inhibition of PHA, mixed lymphocyte and GVH reactivity.


Biological effects of the adjuvant Corynebacterium parvum. II. Evidence for macrophage-T-cell interaction.


Pharmacology of bronchoconstriction.

Pharmacology of bronchoconstriction.


The pharmacology of bronchiolar muscle relaxation.


The effect of age differences in ability-extraneous performance variables on the assessment of intelligence in children, adults, and the elderly.


Effect of salbutamol on pulmonary circulation, ventilation and gas exchange in patients with chronic obstructive airways disease. Preliminary report.


Adrenal catecholamine levels and synthesizing enzyme activities in newborn swine exposed to cold and 6-hydroxydopamine.


Enhanced hepatic microsomal activity by pretreatment of rats with acetone or isopropanol.


Effect of 17-ketosteroids on glucose-6-phosphate dehydrogenase activity (G6PD) and on G6PD isoenzymes.


Ventilation-perfusion relationships studied with  133 xenon before and after bronchodilating drugs in patients with obstructive lung disease.


Soluble H-2 antigens: effect on graft-versus-host reaction and factors influencing its effect on host-versus-skin-graft reaction.


Use of antilymphocyte serum and bone marrow for production of immunological tolerance and enhancement: review and recent experiments.


Active or passive enhancement and allograft survival.


The problems and practice of bone marrow transplantation in man: the severe combined immunodeficiency syndrome as the ideal model.


The use of cyclophosphamide for clinical marrow transplantation.


Leukemic transformation of engrafted human marrow.


Activity of catecholamine enzymes in vas deferens during nerve stimulation.


Analeptic effects of N-sulfamoyl-hexahydro-azepine, SaH 41-178.


Elevation of ventricular fibrillatory threshold by beta-adrenergic blocking agents.


Histamine-like actions of 3 -aminoethyl-1,2,4-triazole.


On the mechanism of carbon tetrachloride toxicity--coincidence of loss of drug-metabolizing activity with peroxidation of microsomal lipid.


Aniline hydroxylation in the human placenta--mechanistic aspects.


Enzymes in cancer.

Enzymes in cancer.


Improved manual and automated colorimetric determination of serum glucose, with use of hexokinase and glucose-6-phosphate dehydrogenase.


Relationship between repression-sensitization and A-B therapist types.


Relation between locus of control and the MMPI with obese female adolescents.


A word association measure of severity of current symptoms in schizophrenia.


Clinicians' multidimensional perceptions of MMPI scales.


Patterns of masculinity-femininity among college- and noncollege-oriented police officers: an empirical approach.


Relationship of MMPI alcoholism, prison escape, hostility control and recidivism scales to clinical judgments.


A new empirical automated MMPI interpretive program: the 1-2--2-1 code type.


A new empirical automated MMPI interpretive program: the 2-7--7-2 code type.


A new empirical automated MMPI interpretive program: the 6-9--9-6 code type.


Maximizing classification rates of Marks and Seeman code types.


Racial comparisons on the Minnesota Multiphasic Personality Inventory.


MMPI changes associated with short-term psychiatric hospitalization.


Personality characteristic differences between alcoholics who leave treatment against medical advice and those who don't.


Variables that differentiate between single- and multiple-admission psychiatric patients at a state hospital over a 5-year period.


High-, average- and low-rated clergymen in a state hospital clinical program.


Excretion of an antihistamine principle in mammals.


Comparative dental caries activity in dropouts and non-dropouts from a three-year study.


Emergency intravenous cholangiography in patients with acute abdominal pain.


An effect of ethanol administration on tryptophan oxygenase in the perfused rat liver. Decreased enzyme synthesis dependent on low perfusate pH.


Effects of vitamin K and naphthoquinones on lipid peroxide formation and oxidative demethylation by liver microsomes.


Significance in vivo of the increase in microsomal ethanol-oxidizing system after chronic administration of ethanol, phenobarbital and chlorcyclizine.


Effect of chlorpromazine on induction of different hepatic enzymes.


Cytochrome P-450 in 7 -hydroxylation of taurodeoxycholic acid.


Dihydrofolate reductases of Escherichia coli and bacteriophage Tr. A spectrofluorometric study.


Intravenous pyelography in asymptomatic cryptorchid males.


Studies on adrenal steroid hydroxylases. Oxidation-reduction properties of adrenal iron-sulfur protein (adrenodoxin).


Orthopaedists aid ballet.

Orthopaedists aid ballet.


Isolation and properties of glutamate dehydrogenase from pea chloroplasts.


Gamma-irradiated flavin adenine dinucleotide: a D-amino acid oxidase inhibitor.


Acute dytonia due to phenothiazines.

Acute dytonia due to phenothiazines.


Milk fluoridation as a public health measure.


Membrane current and contraction in frog atrial fibres. 1. Membrane current and mechanical activity were recorded from short segments of frog atrial muscle strips using a double sucrose gap voltage clamp arrangement. Experiments were performed at 4-7 degrees C. Two types of contraction were observed dependent upon the duration of the clamp.2. Short-lasting depolarizations caused a flow of Ca inward current, I(Ca), and development of a phasic contraction. Time to peak tension approximated 400 msec. Both I(Ca) and contraction, as functions of membrane potential, had a threshold of about - 40 mV and were maximal at inside positive potentials in normal Ringer fluid. Peak tension decreased at strong depolarizations.3. The minimum time of depolarization required for initiation of a phasic contraction was 40-70 msec. The time necessary for full activation of contraction was 200-300 msec and comparable to the period of time covered by the flow of I(Ca).4. There was no marked change in peak tension upon repetitive depolarization to the same membrane potential.5. Restoration of (phasic) contractility after a preceding contraction was strongly dependent on the level of membrane potential between conditioning and test pulse. Restoration was half complete at potentials around - 45 mV.6. Long-lasting depolarizations generated tonic (sustained) contractions superimposed on the phasic (transient) ones. Threshold potential for initiation of tonic contractions was usually positive to the threshold of phasic contractions. The time taken to attain the final level of tension ranged between 0.7 and 3 sec. Plateau tension, as a function of membrane potential, increased with increasing depolarization and reached a flat maximum at about + 50 mV in normal Ringer fluid.7. At membrane potentials near zero level, plateau tension developed by the tonic mechanism was about twice peak tension due to phasic contraction.8. Removal of Ca ions from the external medium resulted in an almost complete abolition of phasic contraction within 1-2 min and a gradual decrease of tonic contraction during the first 10 min. Application of a ;Ca inhibitor' to normal Ringer fluid caused a strong reduction of both I(Ca) and phasic contraction without affecting tonic contractions.9. It is concluded that phasic contractions are directly activated by the flow of I(Ca). Generation of tonic contractions may be attributed to a Ca transfer mechanism different from I(Ca) or a release of Ca from intracellular stores.


Acid phosphatases of the rat testis in experimental conditions.


Histocompatibility in humans.

Histocompatibility in humans.


Effects of daily rinsing and ingestion of fluoride solutions upon dental caries and enamel fluoride.


Heat lability of NADPH at physiologic pH.


Influence of dietary iron levels on hepatic drug metabolism in vivo and in vitro in the rat.


Studies on the localization of reaction sites within the reduced nicotinamide-adenine dinucleotide phosphate-oxygenase system of rat liver microsomes for the N- and C-oxidation of dimethylaniline and for the peroxidation of unsaturated fatty acids.


Inhibition of tyrosine hydroxylase by naphthoquinone pigments of echinoids.


The stereochemistry of the reduction of mevaldic acid-coenzyme A hemithioacetal by rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase.


The purification and properties of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria.


Keratoconjunctivitis sicca caused by sulfadiazine.


The relationship of the nurse and the physician's assistant.


First international education conference in health sciences.


You believe--I believe. Health care is a priority.


Possible role of NADPH-dependent enoyl coenzyme A reductase in  -oxidation of unsaturated fatty acids.


Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase.


Effects of new beta-blocking agent (DL-tiprenolol) on conduction within normal and anomalous atrioventricular pathways in Wolff-Parkinson-White syndrome.


Pulmonary eosinophilia associated with vasculitis and extra-vascular granulomata. A case report and review of the literature.


Functions of thymus-dependent lymphocytes.


Haemodynamic effects of selective beta-adrenergic blockade during acute stage of myocardial infarction.


Cutaneous polyarteritis.

Cutaneous polyarteritis.


Early changes at the node of Ranvier in segmental demyelination. Histochemical and electron microscopic observations.


Metabolism of steroid hormones, sterols, and bile acids in liver microsomes from male, female, and male-pseudohermaphroditic rats.


Studies on the metabolism of steroids in the foetus. Metabolism of 4-androstene-3,17-dione by human foetal-liver microsomes.


Lipogenesis in chicken uropygial glands.


Cigarette smoking and personality.

Cigarette smoking and personality.


Kinetic studies on the enzyme-substrate complex formation of p-hydroxybenzoate hydroxylase by the stopped-flow method.


Synthesis of biologically active triazenes from isolable diazoniums salts.


The interaction between pyrimidine nucleosides and benzene in aqueous solution, studied by proton magnetic resonance.


Photochemically active chlorophyll-containing proteins from chloroplasts and their localization in the thylakoid membrane.


Electrochemical evidence of specific action of indole acetic acid on membranes in Mnium leeaves.


Transcription and degradation of heavy (pre 28S)RNA and 4S RNA during embryogenesis in Limnaea.


Cleavage of ATP by mouse uterine chromatin after in vivo administration of oestradiol.


Demonstration of blood group substance H and galactosyl groups on Candida albicans.


Nonphysicians for coronary care delivery: are they legal?


Pneumococcal meningitis: the problem of the unseen cerebrospinal fluid leak.


Pathways for androgen synthesis in vitro by the testes of Japanese quail (Coturnix coturnix japonica).


Immunologic induction of malignant lymphoma: genetic factors in the graft-versus-host model.


Sulphasalazine induced lung disease.

Sulphasalazine induced lung disease.


The alpha and beta adrenergic responses to epinephrine in the rabbit eye.


Modification by ethanol of the hepatic triglyceride response to chronic administration of chlorcyclizine and DDT.


Training and functions of ophthalmic assistants. Kenya.


Public health ophthalmology within the nations. Introduction.


Gender identity. The problem of a true hermaphrodite. II.


Degree and duration of skin test suppression and side effects with  antihistamines. A double blind controlled study with five antihistamines.


Training and functions of ophthalmic assistants. Africa.


The effect of adenosine 3',5'-cyclic-monophosphoric acid on the 17beta-hydroxysteroid dehydrogenase of rat testis.


Enzyme response of traumatized tissue after intracortical injection into 5 day old rat brain. Penetration of a microneedle and injection of 4 μl. saline into the neocortex of the 5 day old rat brain produced no changes in behaviour of the rats up to 21 days post-injection. Within 24 hours sections indicated that tissue damage was apparent only at the pia-arachnoid membrane and where fluid was released; elsewhere the needle pathway was identified by the enzyme response. The enzyme histochemistry showed a marked increase in glial cell activity of some phosphatases within 24 hours at the site of injury; the pia-arachnoid and outer limiting membrane also showed abnormally high phosphatase reactions. NADH(2)-diaphorase was the only dehydrogenase that was raised in some nerve and glial cells at 24 hours post-injection but other dehydrogenases, mainly LDH and SDH, showed changes at four days post-injection. The phosphatases and 5'-nucleotidase previously showing intense glial cell enzyme reactions appeared to reach peaks of activity at eight days, and at 16 days the onset of scarring was apparent. In the pia-arachnoid enzyme activity increased to 21 days. Some enzymes, particularly AChE and MAO, showed no alterations of note throughout.


Cryptorchism and character: a case study.


The patterns of RNA synthesis and induction of glycogenic enzymes in rat liver under continuous cortisol administration.


Auxiliary ophthalmic training. The Joint Commission on Allied Health Personnel in Ophthalmology.


Auxiliary ophthalmic training in Canada.


Training and functions of ophthalmic assistants. India.


Training and functions of ophthalmic assistants. Ethiopia.


Regional organization of ophthalmic services in Malawi.


Cholinergic mechanism--monoamines relation in certain brain structures.


Ternary complexes in solution. XIV. The stability increasing effect of the pyridyl and imidazole groups on the formation of mixed amine-copper(II)-adenosine 5'-monophosphate complexes.


Purification and immunological identification of bovine retinal aldose reductase.


The diagnosis and adrenergic therapy of open-angle glaucoma.


Electron spin resonance spectrum of a new anthraquinone aglycone (Nodosin).


On the reaction of D-amino acid oxidase with  -chloroalanine.


Viscometric studies on the stability of DNA-proflavine complex.


Isoelectric behaviour of different rabbit interferons induced by Newcastle disease virus.


On the participation of singlet oxygen in the acridine orange sensitized photoinactivation of lysozyme.


Isolation of (--)-manool from the liverwort, Jungermannia torticalyx.


n-Paraffins from flowers of L. umbellata Thumb.


Modification of platelet function.

Modification of platelet function.


Bronchial secretions and mucociliary clearance. Biochemical characteristics.


The oxidation of external NADH by adult and plerocercoid Diphyllobothrium latum.


The triphasic response of the isolated superior cervical ganglion of the rat to cholinergic stimulants.


Tabulation of somatic cell hybrids formed between lines of cultured cells.


Effect of cobra venom factor on the local GVH reaction. I. Partial characterization of a cytotoxic factor from cobra venom for rat lymphocytes.


Prevention of marrow allograft rejection with radioactive strontium: evidence for marrow-dependent effector cells.


Graft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors.


Increased responsiveness to phytohemagglutinin and graft-vs-host reactivity of thymus cells from Snell-Bagg dwarf mice.


Antibodies against sporozoites of human and simian malaria produced in rats.


Chlorcyclizine-induced changes in the ovaries and the uterus of rats.


Renal pharmacology of 'shock' and its congeners.


Microsomal enzymes of sterol biosynthesis.


An investigation of interrelated factors affecting the flow and concentration of salt-induced nasal secretion in the duck, Anas platyrhynchos.


The patellar-tendon-bearing (PTB) orthosis.


Sodium and potassium transport in camel red cells.


Respiratory and circulatory responses in a hemoglobin-free fish, Chaenocepahlus aceratus, to changes in temperature and oxygen tension.


Aortic blood flow and cardiac output in the hemoglobin-free fish Chaenocephalus aceratus.


Evolution of catalase in fish.

Evolution of catalase in fish.


A comparative study of transepidermal water loss through the skin of various animals.


The correlation between transepidermal water loss and the thickness of epidermal components.


Alanine flux across rabbit Peyer's patches.


Pituitary gonadotropin release patterns in pre-spawning brook trout, Salvelinus fontinalis, rainbow trout, Salmo gairdneri and leopard frogs, Rana pipiens.


Blood composition in normothermic and hyperthermic kangaroo rats Dipodomys merriami and laboratory rats Rattus norvegicus.


Responses of some hematologic parameters of active and hibernating squirrels (Spermophilus mexicanus) upon exposure to hypobaric and isobaric hyperoxia.


Red cell survival in the gerbil (Meriones unguiculatus).