Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane. 1. In cats, the effects of intraperitoneal injections of four monoamine oxidase (MAO) inhibitors, tranylcypromine, pheniprazine, pargyline, and nialamide, were examined on rectal temperature and on the hypothermia during anaesthesia produced by a 2 hr period of halothane inhalation.2. A 2 hr period of halothane inhalation produced a steady fall in temperature amounting to between 2 degrees and 3.5 degrees C. After discontinuation of halothane inhalation, temperature quickly returned to the pre-anaesthetic level but no pyrexia developed. A peculiar stiffness of the leg muscles occurred in several experiments either at the beginning of the inhalation or after its discontinuation.3. An injection of tranylcypromine (5 mg/kg) caused a rise in rectal temperature and prevented the hypothermia of halothane anaesthesia. This effect lasted for at least 4 hr; 20 hr after the injection, halothane again caused hypothermia.4. An injection of pheniprazine (10 mg/kg) usually caused a small rise in temperature which was not sustained. Pheniprazine not only prevented the hypothermia of halothane anaesthesia during the subsequent 20 hr, but during the first few hours after the injection halothane inhalation actually produced a steep rise in temperature.5. An injection of pargyline (50 mg/kg) had no effect on temperature but the hypothermia due to halothane inhalation was prevented 1 hr after the injection and attenuated after 20 hr. Injection of 200 mg/kg caused a steady rise in temperature which was accelerated when halothane was administered 1 hr later.6. An injection of nialamide (10, 25 or 50 mg/kg) had no immediate effect on temperature, but pyrexia developed overnight after the two larger doses. The effect on the hypothermia due to halothane inhalation was greater 20 hr after the injection than it was after 1 to 2 hr. Twenty hours after injection of the two larger doses, halothane no longer produced hypothermia but caused a lethal rise in temperature either during or after its inhalation.7. In rabbits, the effect on temperature of halothane inhalation varied. Either temperature rose slightly or it fell, but not as much as in cats. In one rabbit in which the inhalation had produced a transient rise, pyrexia developed 40 min after discontinuation of halothane.


The inhibitory innervation of the bovine iris sphincter.


The effect of "selective" beta-receptor blocking drugs on the myocardial circulation.


The acute exercise test for the preliminary evaluation of beta-receptor blocking drugs in angina pectoris.


The occurrence of pharmacologically active substances in, and the action of drugs on, preparations of the sea anemone Actinia equina.


Beta-receptors in human isolated smooth muscle.


Renal actions of dihydroergocristine and of phentolamine in anaesthetized cats. 1. Comparison has been made of the effects of dihydroergocristine (DCS) and phentolamine mesylate (phentolamine) on cardiac and respiratory rates, systemic arterial pressure, renal clearances of creatinine (C(Cr)) and of p-amino-hippuric acid (C(PAH)) and on the secretion of Na and K, in cats under chloralose anaesthesia.2. Phentolamine antagonized vasomotor tone and the pressor effect of circulating noradrenaline to comparable extent. The extent of reduction in urine flow, C(Cr), C(PAH) and Na excretion correlated with the fall in mean arterial pressure. Innervated and denervated kidneys responded similarly. Cardiac and respiratory rates rose slightly as arterial pressure fell.3. DCS, 10 to 20 mug/kg per min, did not reduce vasomotor tone, markedly reduced the pressor effect of exogenous noradrenaline, caused bradycardia and respiratory slowing but had little or no effect on renal function.4. DCS, 30 to 40 mug/kg per min, lowered mean arterial pressure by 15-25 mm Hg, decreased C(PAH) but not C(Cr), so raising the filtration fraction and caused a small reduction in urine flow and in Na excretion. Innervated and acutely denervated kidneys responded similarly.5. DCS, 30 to 40 mug/kg per min, raised mean arterial pressure, decreased C(PAH), urine flow and Na excretion but did not alter C(Cr) in animals pretreated with full alpha-adrenergic blocking doses of phentolamine.6. DCS, 30 to 40 mug/kg per min, increased the rate of secretion of sympathetic amines from the adrenal medulla and increased the concentration of renin in renal venous blood.7. Isolated kidneys perfused at constant pressure from pump-oxygenator circuits and in saline diuresis responded to DCS (15-17 mug/120 ml. blood) by diuresis and natriuresis and by a rise in the rate of secretion of renin. Higher concentrations of DCS (125-250 mug/120 ml.) were without effect on renal function and did not influence renin secretion.8. The renal effects of full alpha-adrenergic blocking doses of DCS and of phentolamine were comparable, in the whole animal.9. The evidence indicates that the release of noradrenaline by DCS 30-40 mug/kg per min from nerve terminals supplying the juxtaglomerular apparatus may have caused the enhancement of renin secretion.


The activities of NADP transhydrogenase and cytochrome c reductases in developing chick embryos, especially at hatching.


Study on some selective beta-adrenoreceptor blocking effects of 1-(4-nitrophenyl)-1-hydroxy-2-methyl isoproylaminoethane (alpha-methyl INPEA). 1. The effect of methyl substitution in the alpha-carbon position of the ethanolamine side chain of INPEA was investigated on its beta-adrenoreceptor blocking activity in the isolated turtle heart and anaesthetized cats.2. In the turtle heart preparation, the pA(2) value for erythro-alpha-methyl INPEA was 5.3, as compared with 6.9 for INPEA, while threo-alpha-methyl INPEA was extremely weak and its pA(2) value could not be determined.3. In the intact cat experiments, alpha-methyl INPEA produced a competitive blockade of the peripheral vasodilator effect of isoprenaline in doses ranging from 5 to 20 mg/kg. However, this agent had a minimal effect on the cardiac stimulant effect of the catecholamine.4. These results are consistent with the hypothesis that the beta-adrenoreceptors comprise a family of nonhomogeneous receptors and a selective blockade of only some, but not all, responses mediated through their activation can be achieved by specific molecular modification of the beta-adrenoreceptor blocking agents.


A method for the fluorimetric determination of 4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB46), a beta-blocking agent, in plasma and urine.


Optimum level of combined adrenergic blockade for the experimental study of hemorrhagic shock.


Effect of bilirubin on glucose oxidation in red cells.


Stero-bile acids and bile alcohols. CV. Conversion of 7alpha, 12-alpha-dihydroxycholest-4-en-3-one to 5-alpha-cyprinol by carp liver.


Studies on the microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rabbit liver.


Studies on p-hydroxybenzoate hydroxylase from Pseudomonas putida.


Existence and properties of two malic enzymes in Escherichia coli especially of NAD-linked enzyme.


Feedback inhibition of an allosteric triphosphopyridine nucleotide-specific isocitrate dehydrogenase.


Polymyalgia rheumatica: a not so benign syndrome.


Cogan's syndrome. Signs of periarteritis nodosa and cerebral venous sinus thrombosis.


Fee moderation is essential.

Fee moderation is essential.


Gastric polyposis.

Gastric polyposis.


Pitfalls in the diagnosis of subclavian steal.


Group practice in the education of medical students.


Appendix veriforms: an unusual anatomical variation.


Prescription for the minister.

Prescription for the minister.


Effect of maternal virus infections on the fetus. I.


SAMA viewpoints explored.

SAMA viewpoints explored.


Extended care facilities and the geriatric patient.


Water related tularemia cases in Illinois.


School lunch program.

School lunch program.


Truth in lending.

Truth in lending.


Clinical cutaneous lesions in the collagen diseases.


Creative nursing: a need to identify and develop the creative student.


The effect of a new beta blocking drug (butidrine) on some biohumoral indices, liver and kidney function and exercise tolerance.


A behavioral checklist for estimating the development of communication skills.


Message from the White House.

Message from the White House.


Planning for priorities in quality nursing care.


Comparative in vitro evaluation of cryogenine, cyproheptadine, and diphenhydramine as antagonists of furtrethonium, histamine, and serotonin.


Factors relating to the aerobic capacity of 46 healthy British males and females, ages 18 to 28 years.


Biosynthesis of alkyl-ether containing lipid from dihydroxyacetone phosphate.


Calcium-triggered light emission in Renilla. A unitary biochemical scheme for coelenterate bioluminescence.


Systematic desensitization versus implosive therapy.


The MMPI and recidivism.

The MMPI and recidivism.


Positional information and the spatial pattern of cellular differentiation.


A phase-shift model for the spatial and temporal organization of developing systems.


The value of blood flow measurements in acute arterial surgery.


Rise time of the light induced electrical field across the function membrane of photosynthesis. Registration by repetitive laser giant pulse photometry.


On metastable states of carotenoids in primary events of photosynthesis. Registration by repetitive ultra-short-flash photometry.


Chloroazobenzenes: studies on syntheses.


Chloroazobenzenes: IR and UV characteristics.


Studies on beta-lactams.

Studies on beta-lactams.


Properties of the photoactive chlorophyll-aII in photosynthesis.


Further evidcence for an optical response of chloroplast bulk pigments to a light induced electrical field in photosynthesis.


Intracellular localization of enzymes in leaves and chloroplast membrane permeability to compounds involved in amino acid syntheses.


Inhibitory effects of various agents on the activity of tropinesterases.


The turnover of the protein of the inner and outer mitochondrial membrane of rat liver.


Compensatory hypertrophy of testicle in unilateral cryptorchidism.


Immunosuppressive action of mitomycin C on lymphoid cells. I. Effect on cell-mediated immunity after in vitro treatment, tolerance induction, and recovery in vivo.


Morphological and biochemical changes in rat liver during the early stages of ethyl chlorophenoxyisobutyrate administration.


The type-specific substance from Pneumococcus type 11A(43). 1. The type-specific substance from Pneumococcus type 11A(43) is a polymer containing d-glucose, d-galactose, glycerol, phosphate and O-acetyl in the approximate molecular proportions 2:2:1:1:2. 2. Removal of the O-acetyl groups with ammonia gave a compound no longer active towards type 11A antiserum. 3. Treatment of S.11A with sodium borohydride, followed by hydrolysis with alkali yielded a phosphorus-free polysaccharide, whose structure was studied by methylation and by degradation with periodate. 4. Examination of S.11A and its de-O-acetyl derivative by periodate oxidation led to the partial structure (XI) for the type-specific substance, which thus has several features in common with S.18.


Chemotherapy in dental practice barbiturate substitutes. II. Hydroxyzine, methapyrilene, and pyrilamine.


A survey of varsity basketball players in the Rochester area.


Pleuropneumonic reactions to nitrofurantoin.


Beta adrenergic blockaden cariovasculhapy.


Mentally retarded child and pharmacologic therapy.


Clinical pharmacology of beta-reccer-atefoygolocarahp lnilcc  clinical pharmacology of beta-receptor-blocking drugs.


Atypical interstitial pneumonia.

Atypical interstitial pneumonia.


The "energized state" of mitochondria: lifetime and ATP equivalence.


The effects of plastocyanin on photophosphorylation.


Effects of adrenergic blocking agents on basal and stimulated thyroid function.


Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs.


The innervation of the oesophagus of the sea-urchin Heliocidaris erythrogramma.


Alprenolol in angina pectoris. A clinical and ergometric study with a new beta-adrenergic blocking agent.


A sequential comparison of amitriptyline, perphenazine and the amitriptyline-perphenazine combination in recently admitted anergic schizophrenics.


Studies on heart anaphylaxis. II. Effect of histamine and antigen on heart failure in heart-lung-preparation of guinea-pigs.


Effects of the beta adrenergic blocking agents, propranolol, KO592, and MJ-1999 on phenoxybenzamine blockade of norepinephrine.


Inhibition of tyrosine transaminase activity by norepinephrine.


Identification of a thioredoxin induced by bacteriophage T4.


Effect in man of the addition of tryptophan oniacin to the diet on the excretion of their metabolites.


Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.


The effect of dipyridamole on the metabolism of cardiac muscle.


The effects of thyroxine on rat heart adenosine 3',5'-monophosphate, phosphorylase b kinase and phosphorylase a activity.


Blockade of cardiac effects of isoproterenol by 4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide (ICI 50,172).


Antiarrhythmic actions of 4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide (ICI 50,172) in the dog heart-lung preparation.


Supersensitivity to the central stimulant actions of adrenergic drugs following discontinuation of a chronic diet of alpha-methyltyrosine.


Two slow conduction systems in the sea anemone Calliactis parasitica.


Rapid contractions and associated potentials in a sand-dwelling anemone.


The pharmacology of iprindole, a new antidepressant.


The detection of drugs at therapeutic concentrations as applied to aviation accident toxicology.


Infrared identification of lysergide (LSD).


The flow of granular solids through circular orifices.


The effect of dimensions on the compaction properties of sodium chloride.


Potential antiparkinsonism agents. Quinuclidinyl benzhydryl ethers.


On the local anaesthetic effect of barbiturates.


The effect of sodium salicylate on the binding of L-tryptophan to serum proteins.


The inhibition of human platelet 5-hydroxytryptamine uptake by tricyclic antidepressive drugs. The relation between structure and potency.


Some physico-chemical properties of amphetamine and related drugs.


On the mechanism of 5-hydroxytryptamine release by thymoleptics.


Anti-amphetamine activity of fenfluramine and S 992 in the isolated tail artery of the rat.


Concerning the histamine receptor (H1).

Concerning the histamine receptor (H1).


Effect of diazepam on plasma corticosterone levels in the rat.


Diethyldithiocarbamate and structurally-related compounds and the uptake and release of noradrenaline in the heart of the rat.


Cardiovascular effect of a prostaglandin isolated from a gorgonian Plexaura homomalla.


An improved method for the preparation of adnamine.


Modification of the Randall-Selitto analgesic apparatus.


A simplified dissolution rate apparatus.


Experiences of alcoholics during hypnosis.


Psychiatric consultation for a local welfare center.


Acute inflammation: a combined light- and electron-microscope study of the vascular response to incisional and crushing injury of skeletal muscle in the rat.


Scandinavian Symposium in Periodontology 1968.


Anderson dental survey.

Anderson dental survey.


Ecological studies of Japanese encephalitis virus in Mie Prefecture. I. Viremia in natully infected pigs and viremic mosquitoes.


Comparative experimental infections with Costa Rican strains of Leishmania braziliensis Vianna, 1911.


Immunoglobulins and antibodies in Borrelia turicatae infections.


Distribution of Toxoplasma cysts in the central nervous system of slow loris, Nycticebus coucang.


Tick-host relationships. 1. The existence of a circadian rhythm of "drop-off" of engorged ticks from their hosts.


The Javen rhinoceros (Rh. sondaicus Desm.) in Udjung Kulon Nature Reserve. Its ecology and behavior. Field study 1967 and 1968.


Second conference on psychophysiological aspects of cancer.


Blockade of cardiac effects of isoproterenol by the stereoisomers of sotalol.


Drug induced changes in the distribution of 14C5-HT in the pithed reserpinized rat.


A further study of the effect of propranolol on the blockade of alpha adrenergic receptors.


Effects of the adrenergic receptor blocking agents on the ganglionic transmission.


Inhibition of tone in the taenia of the guinea pig caecum.


Physiological and psychological evaluation of the estrogen deprived patient.


Prolonged survival of H-2 incompatible skin allografts on F1 animals treated with parental lymphoid cells.


An unusual inhibitory effect of histamine: suppression of atropine-resistant tetanic spasms after mepyramine block of histamine contractions.


The effects of psychotropic drugs on the double alley frustration effect.


Acquisition and retention of a conditioned avoidance response in mice as influenced by pemoline, by some of its derivatives and by some CNS stimulants.


Assessment of anti-reserpine and anti-apomorphine activities of some psychic energizers in pigeons.


The effect of bacterial T- activating enzymes on the red cell Sp1 antigen.


Sex-linked difference in the specific activity of some dehydrogenases isolated from hamster-liver and hamster-kidney.


The guilt reaction of parents of children with severe physical disease.


The ultrastructure of the zymogen cells in Hydra viridis.


Increase in gustatory acuity and hyperarousal in schizophrenia.


Public health problems arising out of man-made fish ponds in the Western Province of Kenya fish culture.


Some pharmacological actions of cyclizine, chlorcyclizine and homchlorcyclizine.


The mechanism of hypotensive action of N-(2-(2-methoxyphenoxy) ethyl)-3-(2, 5-dimethoxyphenoxy) propylamine hydrochloride.


Abrupt fall in blood pressure by intravenous injection of triphosphopyridine nucleotide.


Heat labile opsonins to pneumococcus. I. Participation of complement. Heat labile opsonins (HLO) in normal rat serum to both encapsulated and unencapsulated pneumococci (a) have the same heat lability as complement (C); (b) are active at 37 degrees C but not at 0 degrees C; (c) are inactivated proportionately to hemolytic C by the addition of immune aggregates to the serum; (d) are adsorbed from serum nonspecifically by bacteria at 37 degrees C but not at 0 degrees C; (e) are Ca(++)- and/or Mg(++)-dependent in their action; and (f) are inactivated by zymosan and a purified cobra venom factor, and in the case of encapsulated pneumococci, at least, by NH(4)OH. Like other opsonins, HLO to pneumococci act primarily on the bacteria rather than on the phagocytes. Their combined properties indicate that they involve multiple components of the hemolytic C system. Since HLO are immunologically polyspecific, they presumably play a broad protective role in the early (preantibody) phase of acute bacterial infections.


Histometric assessment of human testicular biopsies.


Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5. When encapsulated type 25 pneumococci (Pn25) were opsonized with normal guinea pig serum, they consumed much more C3 than other complement (C) components. Fixation of C3 to the organisms was demonstrated by radio-labeling techniques, and its capsular localization was established by the use of monospecific anti-C3 antibody. Treatment of the serum with an appropriate dose of a purified cobra venom factor (VF) destroyed C3 and all of the opsonic activity, without appreciably affecting the other C components. Addition of purified C3 completely restored the opsonic activity of the VF-treated serum, indicating a requirement for C3. Since purified C3 alone had no opsonic activity, it was concluded that the C3 molecules had to be cleaved (to C3b) to function as opsonins. Experiments with C5-deficient mice revealed that C5 also plays a definite, but quantitatively less impressive, role in antipneumococcal defense.


Therapy of acute salicylate ingestion.

Therapy of acute salicylate ingestion.


Effects of prostaglandin and beta-adrenergic drugs on ocular pressure  and pupil size.


Light-phosphoenolpyruvate dependent carbodioxide fixation by isolated sugar cane chloroplasts.


Dehydrogenae-reduced coenzyme difference spectra, their resolution and relationship to the stereospecificity of hydrogen transfer.


Psychiatric diagnosis: a review of research.


Illicit LSD users: their social backgrounds, drug use and psychopathology.


Spasmolytic activity of some newer quinazolones.


Immunologic competence of bone marrow of different genotypes.


Metabolic fate of hydrazines and hydrazides.


Chromatographic analysis of chlorpheniramine, pyrilamine, and methapyrilene in combination.


Current concepts. Sleep: biochemical aspects.


Personality and smoking patterns in a twin population.


Drug advertising.

Drug advertising.


Personality and respiratory responses to sound and light.


Allergy.

Allergy.


An epidemiologic investigation of predictor variables associated with intramural touch football injuries.


Comparison of the antilethal, broncholytic, and antiemphysematous activities of mepyramine in anaphylactic, histamine, and anaphylatoxin shock of guinea-pigs.


The adrenergic-receptor blocking action of verapamil.


Potentiation of the effects of catecholamines by alpha- and their antagonism by beta-adrenergic blocking agents on the guinea-pig isolated trachea in vitro and on the guinea-pig lungs in vivo.


Blockade of conduction in vagal fibers by nicotinic drugs.


Effects of phentolamine on responses of the normal and of the denervated nictitating membrane of the pithed cat to tyramine.


Thyroid storm. A review of 22 episodes with special emphasis on the use of guanethidine.


Influence of microsomal enzyme inducers on the reactivity of the isolated guinea pig seminal vesicle to angiotensin and tyramine.


Effects ofrypsin on the electron transport systems of liver microsomes.


Enzymes of fructose metabolism in the liver of some vertebrates.


The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450. 1. The effects of unsaturated fatty acids on drug-metabolizing enzymes in vitro were measured by using rat and rabbit hepatic 9000g supernatant fractions. 2. Unsaturated fatty acids inhibited the hepatic microsomal metabolism of ;type I' drugs with inhibition increasing with unsaturation: arachidonic acid>linolenic acid>linoleic acid>oleic acid. Inhibition was independent of lipid peroxidation. Linoleic acid competitively inhibited the microsomal O-demethylation of p-nitroanisole and the N-demethylation of (+)-benzphetamine. 3. The hepatic microsomal metabolism of ;type II' substrates, aniline and (-)-amphetamine, was not affected by unsaturated fatty acids. 4. The rate of reduction of p-nitrobenzoic acid and Neoprontosil was accelerated by unsaturated fatty acids. 5. Linoleic acid up to 3.5mm did not decelerate the generation of NADPH by rat liver soluble fraction, nor the activity of NADPH-cytochrome c reductase of rat liver microsomes. Hepatic microsomal NADPH oxidase activity was slightly enhanced by added linoleic acid. 6. No measurable disappearance of exogenously added linoleic acid occurred when this fatty acid was incubated with rat liver microsomes and an NADPH source. 7. The unsaturated fatty acids used in this study produced type I spectra when added to rat liver microsomes, and affected several microsomal enzyme activities in a manner characteristic of type I ligands.


The inhibitory effect of some thiazide diuretics and acetazolamide on the histamine induced gastric secretory response in pigeons.


Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine.


Radiation protection at the National Nuclear Research Centre, Pelindaba.


Blockade of superior cervical ganglionic transmission by tropine-p-tolylacetate and its quaternary methiodide derivative.


Lymphoproliferative lesion in congenital thymic aplasia associated with agammaglobulinemia.


Diagnostic and therapeutic advantages of serial quantitative cultures of fresh sputum in acute bacterial pneumonia.


Application of verbal behavior analysis to the study of psychological defense mechanisms. V. Speech pattern associated with overeating.


Particulate enzymes of the glyoxylate cycle in Neurospora crassa.


Pharmacological properties of tofenacine hydrochloride: N-methyl-2-[(o-methyl-a-phenylbenzyl)oxy]ethylamine hydrochloride.


Analysis of hormonal-dietary interactions and the role of gluconeogenesis in the regulation of tyrosine aminotranferase in rats.


Studies on hydroid differentiation. V. The control of growth in young colonies of Podocoryne carnea.


What has happened to the AAMC since the Coggeshall Report of 1965?


Implementing the Report of the Citizens Commission on Graduate Medical Education.


Implementing the report of the Ad Hoc Committee on Education for Family Practice.


Implementing the Report of the National Advisory Commission on Health Manpower.


Corticosteroids and allergy.

Corticosteroids and allergy.


Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast.


Binding of substrates by native and chemically modified isocitrate dehydrogenase.


[Solvent effect on fluorescence of fat-soluble riboflavin derivatives].


Biosynthesis of fatty acids in mammary tissue. I. Purification and properties of fatty acid synthetase from lactating-goat mammary tissue.


Biosynthesis of fatty acids in mammary tissue. II. Synthesis of butyrate in lactating rabbit mammary supernatant fraction by the reversal of beta-oxidation.


Mechanism of action of beta-adrenergic receptor blocking agents in angina pectoris: comparison of action of propranolol with dexpropranolol and practolol. The effect on exercise tolerance of racemic propranolol has been assessed in eight angina pectoris patients and compared with that of dexpropranolol (the dextro isomer of propranolol), practolol (I.C.I. 50172), and saline. Dexpropranolol has the same local anaesthetic action as propranolol with negligible beta-adrenergic receptor blocking activity, while practolol is a cardio-selective beta-adrenergic blocking agent which does not have local anaesthetic activity.Saline and dexpropranolol had no significant effect on exercise time; racemic propranolol and practolol improved exercise tolerance in six subjects, the response to the two drugs being very similar in individual patients. It was concluded that the beneficial effect of propranolol in angina pectoris results from its action as a beta-adrenergic receptor blocking agent and is not due to its local anaesthetic, or quinidine-like, activity.


The dental condition of Olympic Games contestants--a pilot study, 1968.


Drug treatment of epilepsy in childhood.


Histochemical and radioautographic studies of serotonin and parafollicular cells in the thyroid gland of the prehibernating bat.


Effect of glucocorticoids on the acid DNase of the thymus.


Erythritol metabolism in wild-type and mutant strains of Schizophyllum commune. Erythritol uptake and metabolism were compared in wild-type mycelium and a dome morphological mutant of the wood-rotting mushroom Schizophyllum commune. Wild-type mycelium utilized glucose, certain hexitols, and pentitols including ribitol, as well as d-erythrose, erythritol, and glycerol as sole carbon sources for growth. The dome mutant utilized all of these compounds except d-erythrose and erythritol. Erythritol- or glycerol-grown wild-type mycelium incorporated erythritol into various cellular constituents, whereas glucose-grown cells lagged considerably before initiation of erythritol uptake. This acquisition was inhibited by cycloheximide. Dome mycelium showed behavior similar to wild-type in uptake of erythritol after growth on glucose or glycerol, except that erythritol was not further catabolized. Enzymes of carbohydrate metabolism were compared in cell extracts of glucose-cultured wild-type mycelium and dome. Enzymes of hexose monophosphate catabolism, nicotinamide adenine dinucleotide (NAD)-dependent sugar alcohol dehydrogenases, and reduced nicotinamide adenine dinucleotide phosphate (NADPH)-coupled erythrose reductase were demonstrated in both. The occurrence of erythrose reductase was unaffected by the nature of the growth carbon source, showed optimal activity at pH 7, and generated NAD phosphate and erythritol as products of the reaction. Glycerol-, d-erythrose-, or erythritol-grown wild-type mycelium contained an NAD-dependent erythritol dehydrogenase absent in glucose cells. Erythritol dehydrogenase activity was optimal at pH 8.8 and produced erythrulose during NAD reduction. Glycerol-growth of dome mycelium induced the erythritol uptake system, but a functional erythritol dehydrogenase could not be demonstrated. Neither wild-type nor dome mycelium produced erythritol dehydrogenase during growth on ribitol. Erythritol metabolism in wild-type cells of S. commune, therefore, involves an NADPH-dependent reduction of d-erythrose to produce erythritol, followed by induction of an NAD-coupled erythritol dehydrogenase to form erythrulose. A deficiency in erythritol dehydrogenase rather than permeability barriers explains why dome cannot employ erythritol as sole carbon source for mycelial growth.


Acute depletion of thyroid ATP and pyridine nucleotides following injection of iodine in the rat.


Enzymes of intermediary carbohydrate metabolism in the obligate autotrophs Thiobacillus thioparus and Thiobacillus neapolitanus. Levels of enzymes operative in the Embden-Meyerhof-Parnas (glycolytic) pathway, pentose phosphate cycle, citric acid cycle, and certain other phases of intermediary carbohydrate metabolism have been compared in Thiobacillus thioparus and T. neapolitanus. All enzymes of the glycolytic pathway except phosphofructokinase were demonstrated in both organisms. There were some striking quantitative differences between the two organisms with respect to the activities of the individual enzymes of the glycolytic pathway and the citric acid cycle. Qualitative differences were also found: the isocitrate dehydrogenase activity of T. thioparus is strictly nicotinamide adenine dinucleotide phosphate (NADP)-dependent, whereas that of T. neapolitanus is primarily nicotinamide adenine dinucleotide-dependent, activity with NADP being low; the glucose-6-phosphate dehydrogenase of T. thioparus is particulate, whereas that of T. neapolitanus is partly soluble and partly particulate; the 6-phosphogluconate dehydrogenase of T. thioparus is soluble, that of T. neapolitanus is partly soluble and partly particulate. All enzymes which function in the carbon reduction cycle were present at very high levels. In contrast, enzymes which operate exclusively in cycles other than the carbon reduction cycle were present at low levels. Of the enzymes not operative in the carbon reduction cycle that were examined, isocitric dehydrogenase had the highest specific activity. Both organisms possessed reduced nicotinamide adenine dinucleotide dehydrogenase activity. The qualitative and quantitative aspects of the data are discussed in relation to possible biochemical explanations of obligate autotrophy.


Microsomal heme oxygenase. Characterization of the enzyme.


The location of different synthetic systems for fatty acids in inner and outer mitochondrial membranes from rabbit heart.


Auxiliary pathways of galactose metabolism. Identification of reaction products of hexose 6-phosphate dehydrogenase and of "galactose dehydrogenase".


Characterization of the fatty acid elongation system in soluble extracts and membrane preparations of rat liver mitochondria.


Cortical cytoplasmic filaments of cleaving eggs: a structural element corresponding to the contractile ring. A sheath consisting of filaments 50-70 A in diameter has been demonstrated in association with the expanded, leading margins of the cleavage furrow in unilaterally and symmetrically cleaving eggs of a jellyfish and a polychaete worm, respectively. The observations suggest that the filament system might provide a structural basis for the existence of the contractile gel that, according to a hypothesis by Marsland and Landau, accomplishes cleavage. The filamentous sheath is present only in the furrow region and is arranged in an arcuate manner in unilaterally cleaving eggs and circumferentially in symmetrical cleavage. The filaments appear to be of finite length, and a number of them must overlap to span the length of the furrow. Contraction may be accomplished if the filaments slide relative to each other. However, contraction per se was experimentally not demonstrated in the studied systems. The disappearance of microvilli and the merocrine type secretion of mucoid droplets at the interdigitating or "spinning" membrane region of unilateral cleavage suggest that the unfolding of a pleated membrane and the insertion of intracytoplasmic membranes might contribute, at least in part, to the necessary extra cell membrane.


Community violence and aggression in dreams: an observation.


Depression of erythrocyte maturation as a result of the graft-vs.-host reaction.


Dengue and chikungunya virus infection in man in Thailand, 1962-1964. V. Epidemiologic observations outside Bangkok.


The effect of alpha and beta adrenergic blockade on thoracic duct lymph flow in normovolemic and hypovolemic dogs.


The effect of ganglionic blockade on the pressor response to angiotensin in systemic hypertension.


Ventrolateral thalamic lesions. The effect on striatal amines in the monkey.


Dengue and chikungunya virus infection in man in Thailand, 1962-1964. IV. Epidemiologic studies in the Bangkok metropolitan area.


Basic genetical and immunological considerations.


Reductive dechlorination of pp'DDT by pigeon liver microsomes.


Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins. Heat-labile opsonins to pneumococci in normal mammalian sera, unlike antibodies, fail to interact with the bacteria at 0 degrees C and require Ca(++) and/or Mg(++). They are readily removed from serum by antigen-antibody complexes that fix complement (C) and are inhibited by reagents that inactivate various C components. The principal heat-labile opsonin to pneumococci is activated C3 (C3(b)), but a slight enhancing effect is exerted by one or more of the late-reacting components of the hemolytic complement system (C5-C9). Since heat-labile opsonins are immunologically polyspecific, they presumably play a broad protective role in the early (preantibody) phase of acute bacterial infections.


The effect of phenoxybenzamine and propranolol and their combination on the restoration of glucose homeostasis after insulin induced hypoglycemia.


Studies on capsella bursa pastoris. II. Diuretic, anti-inflammatory and anti-ulcer action of ethanol extracts of the herb.


A comparative study of the effects of quinidine and a newer antiarrhythmic agent, disopyramide, on mammalian myocardial metabolism of glucose and oxidative phosphorylation.


Cytomorphological alterations of mossy fiber boutons of the hippocampus produced by 3-acetylpyridine, methoxypyridoxine, reserpine, and iproniazid.


Larvae Chaoborinae (Diptera; Culicidae) occurring in small water reservoirs. I. Some observations on larvae of Chaoborus crystallinus (de Geer, 1776) and on the possibility of their predacity in relation to larvae of biting mosquitoes (Diptera; Culicidae, Culicinae).


Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria.


Disulfiram impairment of drug metabolism by rat liver microsomes.


The reversible inactivation of D-glyceraldehyde 3-phosphate dehydrogenase following NAD+ removal.


Measurement of muscle function in astronauts.


Daily variation in rat liver tyrosine transaminase activity.


Daily rhythms in hepatic polysome profiles and tyrosine transaminase activity: role of dietary protein. Hepatic polysome profiles vary in untreated rats as a function of time of day. The ratio of polysomes to total ribosomes increases from 50 to 73 per cent in darkness. There is also a daily rhythm in tyrosine transaminase activity which resembles but does not coincide with the polysome rhythm. Both rhythms are dependent on the cyclic ingestion of dietary protein, and disappear in rats given a protein-free diet.


Control of tyrosine aminotransferase synthesis in tissue culture by a factor in serum. The hormonal induction of tyrosine aminotransferase in an established line of rat hepatoma cells is enhanced by the presence of a macromolecular component of serum in the inducing medium. The addition of serum to cells previously induced in serum-free medium results in a rapid two- to threefold increase in the rate of tyrosine aminotransferase synthesis, as measured by specific radio-immunoprecipitation techniques, as well as a smaller increase in over-all protein synthesis. The stimulation of protein synthesis by serum is accompanied by an increase in the proportion of ribosomes sedimenting as polysomal aggregates. The increase in the rate of TAT synthesis is largely independent of RNA synthesis as it is insensitive to antinomycin D, suggesting that the serum acts at a site beyond gene transcription. The maximum effect of serum on TAT synthesis requires the continued presence of the hormone inducer.


An equine intersex with unilateral gonadal agenesis. Cytogenetic and histological studies have been carried out on an intersex horse which was clinically diagnosed as a cryptorchid. The horse had the general conformation of a stallion but the external genitalia included a well developed vulva and a penis. The right testis which was descended was devoid of germ cells and the left "gonad" located in the cavum vaginale contained neither testicular nor ovarian tissue. The male duct system on both sides were relatively well developed despite the absence of a testis on the left side. Chromosome analysis on cultured cells from the descended testis revealed the presence of four chromosomally-distinct cell types with XX, XY, XXY and XO sex complements indicating a quadruple mosaicism. The presence of polymorphonuclear neutrophils exhibiting a drumstick, in the hemopoietic tissues and a sex chromatin body in the nucleated cells of buccal mucosa suggest that mosaicism prevails in other somatic tissues of the horse. On the basis of information derived from similar conditions in humans and some domestic animals it would appear that this horse resulted from an XXY zygote. The four cell types noted in the horse probably resulted through mitotic mechanisms favouring the loss of an X and a Y at different stages during embryonic development. The absence of gonad on the left side of this horse might be causally related to the preponderance of XO cell types in the somatic blastema during early gonadal differentiation.


Oxidative metabolism of glucose, fructose and galactose by normal and glucose-6-phosphate dehydrogenase-deficient human red cell haemolysates.


A clinical study concerning the anticariogenic effects of NaH2PO4-enriched breakfast cereals in institutionalized subjects: results after two years.


Review of 1969 News.

Review of 1969 News.


Adrenergic agonists and antagonists in the treatment of hypovolemic shock.


Dental health and treatment requirements of South Australian secondary schoolchildren.


The Commonwealth Foundation--progress 1966-69.


Effects of doxapram HCl on gastric secretion in dogs.


Kinetic studies of glutamate dehydrogenase with glutamate and norvaline as substrates. Coenzyme activation and negative homotropic interactions in allosteric enzymes. 1. Kinetic studies of glutamate dehydrogenase were made with wide concentration ranges of the coenzymes NAD(+) and NADP(+) and the substrates glutamate and norvaline. Initial-rate parameters were evaluated. 2. Deviations from Michaelis-Menten behaviour towards higher activity were observed with increasing concentrations of either coenzyme with glutamate as substrate, but not with norvaline as substrate. 3. In phosphate buffer, pH7.0, Lineweaver-Burk plots with either coenzyme as variable and a constant, large glutamate concentration showed three or four linear regions of different slope with relatively sharp discontinuities. Maximum rates obtained by extrapolation and Michaelis constants for the coenzymes increased in steps with increase of coenzyme concentration. 4. In the absence of evidence of heterogeneity of the enzyme and coenzyme preparations, the results are interpreted in terms of negative homotropic interactions between the enzyme subunits. It is suggested that sharp discontinuities in Lineweaver-Burk plots or reciprocal binding plots may be characteristic of this new type of interaction, which can be explained in terms of an Adair-Koshland model, but not by the model of Monod, Wyman & Changeux.


The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. 1. The concentrations of the oxidized and reduced substrates of the ;malic' enzyme (EC 1.1.1.40) and isocitrate dehydrogenase (EC 1.1.1.42) were measured in freeze-clamped rat livers. By assuming that the reactants of these dehydrogenase systems are at equilibrium in the cytoplasm the [free NADP(+)]/[free NADPH] ratio was calculated. The justification of the assumption is discussed. 2. The values of this ratio obtained under different nutritional conditions (well-fed, 48hr.-starved, fed with a low-carbohydrate diet, fed with a high-sucrose diet) were all of the same order of magnitude although characteristic changes occurred on varying the diet. The value of the ratio fell on starvation and on feeding with the low-carbohydrate diet and rose slightly on feeding with the high-sucrose diet. 3. The mean values of the ratio were calculated to be between 0.001 and 0.015, which is about 100000 times lower than the values of the cytoplasmic [free NAD(+)]/[free NADH] ratio. 4. The differences in the redox state of the two nicotinamide-adenine dinucleotide couples can be explained on a simple physicochemical basis. The differences are the result of equilibria that are determined by the equilibrium constants of a number of highly active readily reversible dehydrogenases and transaminases and the concentrations of the substrates and products of these enzymes. 5. The decisive feature is the fact that the NAD and NADP couples share substrates. This sharing provides a link between the redox states of the two couples. 6. The application of the method of calculation to data published by Kraupp, Adler-Kastner, Niessner & Plank (1967), Goldberg, Passonneau & Lowry (1966) and Kauffman, Brown, Passonneau & Lowry (1968) shows that the redox states of the NAD and NADP couples in cardiac-muscle cytoplasm and in mouse-brain cytoplasm are of the same order as those in rat liver. 7. The determination of the equilibrium constant at 38 degrees , pH7.0 and I 0.25 (required for the calculation of the [free NADP(+)]/[free NADPH] ratio), gave a value of 3.44x10(-2)m for the ;malic' enzyme (with CO(2) rather than HCO(3) (-) as the reactant) and a value of 1.98x10(-2)m(-1) for glutathione reductase.


The nature of the carbon dioxide substrate and equilibrium constant of the 6-phosphogluconate dehydrogenase reaction. 1. It was shown that dissolved CO(2) and not HCO(3) (-) or H(2)CO(3) is the primary substrate for reductive carboxylation with 6-phosphogluconate dehydrogenase from sheep liver. 2. The equilibrium constant of the reaction was measured in solutions of various ionic strengths and at several temperatures, and the free energy and heat of reaction were determined.


The effect of various agents on the pressor response to dopa in the anesthetized dog.


The effects of ICI 50172, propranolol, pronethalol and MJ 1999 on beta-receptors.


Sympathetic involvement in vagal escape and the effects of beta-receptor blocking drugs.


Interaction of graft-versus-host reaction and lymphocytic choriomeningitis infection in mice: histopathological changes.


Further studies on the antagonism of stereotyped behaviour induced by amphetamine.


The protection of the anemone fish, Amphiprion xanthurus, from the sea anemone, Stoichactus kenti.


The chromatographic identification of psychotropic drugs.


Regulation of liver tyrosine aminotransferase by endogenous factors in the mouse. The levels of mouse liver tyrosine aminotransferase (TAT) are shown to increase rapidly and transiently during and after various challenges (e.g., exposure to cold or shaking) to the homeostatic machinery of the fasted mouse. The increase of TAT is dependent on gene activity. Recent feeding and adrenalectomy are shown to inhibit the induction of TAT during the challenge of cold.


Ageing and the regulation of cell activities during exposure to cold. The inability to maintain body temperature and a selective pattern of changes in the regulation of cell activities were revealed by briefly exposing ageing C57B1/6J male mice to cold (10 degrees C). The induction of liver tyrosine aminotransferase (TAT) during exposure to cold (a gene-dependent process) was markedly delayed in senescent mice (26 months old) as compared with younger mice (3-16 months old); after the delay, the rate of increase of TAT was similar to that prevailing in younger mice. Direct challenge of the liver with injections of corticosterone or insulin elicited the induction of TAT on an identical time course in young and senescent mice. These experiments provide an example of an age change in a gene-dependent cell process (the delayed induction of TAT in senescent mice during exposure to cold) which is not due to a change in the potential of the genome for responding when exogenous stimulae are supplied (injection of hormones). In contrast to the age-related change in liver cell activities, no significant changes were found in the secretion of corticosterone during exposure to cold. Although the seat of these selective age-related changes in the regulation of cell activities remains unclear, it is argued that generalized damage to the genome of cells throughout the body is not involved. The results of this and other studies showing the selective effect of age on cell activities are considered in terms of the concept that many cellular age changes represent the response of cells to primary age-related changes in humoral factors in the internal environment of the body.


Identification of a urinary metabolite of perazine as a piperazine-2,5-dione derivative.


The effects of etorphine and of morphine on respiration, blood carbon dioxide tension, and carbon dioxide sensitivity in the conscious rabbit.


A perfused tail artery preparation from the rat.


The influence of the monoamine oxidase inhibitor pargyling hydrochloride on the retention of dopamine in the isolated perfused spleen of the cat.


Effects of convulsant barbiturates on vascular smooth muscle.


On the role of a central adrenergic mechanism in morphine analgesic action.


The determination of cellulase activity by viscometry.


The effect of butoxamine, N-isopropylmethoxamine and salbutamol (AH-3365) on melanophore beta-adrenergic receptors.


Assay of acetylcholine using toad rectus abdominis muscle in the presence of hemicholinium-like substances.


Potentiation of [3H]noradrenaline accumulation in rat heart by angiotensin.


The effect of ethanol on the metabolism of amphetamine by the rat.


A rapid method for the extraction of angiotensin II from blood.


Observations on some actions of ergometrine, noradrenaline and dopamine on the guinea-pig vas deferens and on the rabbit jejunum.


Metabolism of exogenous cortisol in the rat in various experimental conditions.


Heats of reaction and stability of caffeine complexes.


Toxicity of ethanol-barbiturate mixtures.


Activity of (+)-amphetamine at different environmental temperatures in three strains of mice.


Interactions of methocarbamol with morphine and aspirin.


Studies on the subcellular distribution of [3H]reserpine.


Alterations in noradrenaline turnover in the peripheral sympathetic neurons induced by stress.


The quantitation of metyrapone and its reduced derivative in urine.


Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose.


Regulation of glycogen metabolism in liver by the autonomic nervous system. 3. Differential effects of sympathetic-nerve stimulation and of catecholamines on liver phosphorylase.


Amylase secretion in rat parotid slices by apparent activation of endogenous catecholamine.


White cell transfusions: six years experience.


The negative inotropic effect of adrenergic betareceptor blocking drugs on human heart muscle.


The role of isoreceptors in the neurohormonal regulation of bivalve hearts.


The use of eight different tetrazolium salts for a quantitative study of pentose shunt dehydrogenation.


Gastrointestinal absorption of two polymorphic forms of aspirin.


Dermatonecrotic properties of extracts from the tentacles of the cnidarian Chironex fleckeri.


A case of polyarteritis.

A case of polyarteritis.


Controlled interviews using drugs.

Controlled interviews using drugs.


Sea wasp (Chironex fleckeri) venom: lethal, haemolytic and dermonecrotic properties.


Enzyme activities during the asexual cycle of Neurospora crassa. 3. Nicotinamide adenosine diphosphate glycohydrolase.


Systematic oscillations in metabolic activity in rat liver and hepatomas: effect of hydrocortisone, glucagon, and adrenalectomy on diploid and other hepatoma lines.


Interaction between tissue glucose-6-phosphate dehydrogenase (G6PD) activities and sex chromatin (SC) frequencies in testosterone propionate treated rats.


The effects of histamine, 5-hydroxytryptamine and bradykinin on rat mesenteric blood vessels.


Histochemical demonstration of enzymes related to NADPH-dependent hydroxylating systems in rat liver after phenobarbital treatment.


Studies upon the mechanism of reserpine-induced arrest in egg transport in the mouse oviduct. II. Comparative effects of some agents with actions on smooth muscle and tissue amines.


Effect of beta-adrenergic blockade and alcohol on simulated car driving.


A simple screening test for glutathione peroxidase activity in red cells.


Interactions of tissue glucose-6-phosphate dehydrogenase (G6PD) activity with age and sexual development in the rat.


Post-vaccinial reactions.

Post-vaccinial reactions.


Reaction of D-amino-acid oxidase with D-lysine.


The value of exploratory laparotomy in fever of undetermined etiology.


Structural relationship and potency of agents which selectively block mouse killing (muricide) behavior in rats.


Serum contributions to culture medium: comparative dehydrogenase activity.


The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.


Changes in the levels of nicotinamide nucleotides and in activities of NADP-dependent dehydrogenases after a brief illumination of red light.


Tybamate: an examination of its actions in "high" and "low" anxious normals.


Spontaneous rupture of pregnant uterus.

Spontaneous rupture of pregnant uterus.


Coronary care unit experience. Clinical experience at Mercy hospital and Medical center.


Should general hospitals admit TB patients?


Pitfalls in the diagnosis of venous thrombosis.


Uterine tumor.

Uterine tumor.


The view box.

The view box.


Rubella.

Rubella.


The ureter in health and disease.

The ureter in health and disease.


Personality correlates of accurate empathy in a college companion program.


Surgical aspects of metastatic bone disease.


SPI discriminators among four psychological health-sickness levels.


Relationship of manifest anxiety to repression-sensitization on the MMPI.


The morphology and anatomy of the flowers of Mitragyna inermis (Willd.) O. Kuntze.


The alkaloids of the leaves of Mitragyna inermis (Willd.) O. Kuntze.


The absolute configurations of the alkaloids of Physostigma venenosum seeds.


Thin-layer chromatography and high voltage electrophoresis of quaternary alkaloids from Fagara species.


Dissolution and absorption of ICI 49,455.


Excretion of cocaine and its metabolites in man.


The influence of substitution in phenylacetic acids on their performance in the buccal absorption test.


Correlation of partition coefficients in n-heptane-aqueous systems with buccal absorption data for a series of amines and acids.


Urinary excretion of the drug and its main metabolite in man, after the administration of (plus or minus)-, (plus)- and (minus)-ethylamphetamine.


The influence of stereochemistry on pKa, rate of quaternization and partition coefficients of corynantheidine-type alkaloids.


Metabolism, excretion and biological availability of 4'-chloro-2-ethylaminopropiophenone.


Some effects of bacterial pyrogens and activated charcoal on polarographic maxima.


Effect of organic matter and increased inoculum size on the minimum inhibitory concentration of crystal violet towards Staphylococcus aureus at various pH values.


The haemolytic activity of sols containing progesterone solubilized by phosphatidylcholine and lysophosphatidylcholine.


Ulcerative colitis in the guinea-pig caused by seaweed extract.


A model for the influence of emulsion formulation on the activity of phenolic preservatives.


The metabolism of thioamides by the supernatant fraction of rat liver homogenate.


The hardness and elastic modulus of some crystalline pharmaceutical materials.


Quality control of white soft paraffin.

Quality control of white soft paraffin.


The preparation and pharmacological properties of psi-corbasil.


The effect of crystal hardness on radial pressure at the wall of a tabletting die.


The effect of particle shape on powder properties.


A quantitative chromatographic method for the determination of purity of oxytetracycline.


A direct non-aqueous titration procedure for determining barbiturates in different pharmaceutical forms.


Determination of 21-acyloxy corticosteroids and other steroid esters.


The gas chromatographic determination of adrenaline in pharmaceutical products.


The gas chromatographic determination of nicotinamide and thiamine in vitamin preparations.


A chromatographic assay for male fern extract.


Crystal growth studies involving phase transitions in aqueous drug suspensions.


The possible use of polytetrafluoroethylene (Fluon) as a tablet lubricant.


Quantitative determination of emetine and cephaëline in ipecacuanha root.


Stabilization of oil-in-water emulsions by non-ionic detergents: electrical and entropic contributions to stability.


Stabilization of oil-in-water emulsions by non-ionic detergents: the effect of polyoxyethylene chain length.


A punched card system for the rapid identification of powdered crude drugs and spices.


The use of a thermoelectric osmometer to measure the osmotic coefficients of aqueous solutions of sodium salicylate at 25 degrees.


The effect of distribution of magnesium stearate on the penetration of a tablet by water.


Caries inhibition by trace elements other than fluorine.


Nerve net models of plausible size that perform many simple learning tasks.


Mechanics of red-cell motion through very narrow capillaries.


Review lecture. Immunosuppressive agents, with special reference to antilymphocytic serum.


The cellular immune response to primary sarcomata in rats. I. The significance of large basophilic cells in the thoracic duct lymph following antigenic challenge.


The cellular immune response to primary sarcomata in rats. II. Abnormal responses of nodes draining the tumour.


Electron-microscopic structure of denervated skeletal muscle.


Oxidative demethylation of N-methylhydrazines by rat liver microsomes.


Multivariate classification of alcoholics by means of the MMPI.


Alcoholism and clinical symptoms.

Alcoholism and clinical symptoms.


Antihypertensive agents 1962-1968.

Antihypertensive agents 1962-1968.


Relationships between the chemical structure and pharmacological activity in a series of synthetic quinuclidine derivatives.


Polymyxin P, new antibiotics of polymyxin group.


Generalizability of California per c5*131-40* A/Norman RD, Fenson JN: Further aspects of construct validity of the Zuckerman Sensation-Seeking Scale.


Conditioned aversion treatment of alcoholics.


My first congress.

My first congress.


Dental caries in U. S. and British adults...a comparison.


Editorial. The ICN Congress.

Editorial. The ICN Congress.


Experimental ischemia in monkeys. 3. Histochemical analysis of gingival epithelium.


A double-blind cross-over clinical valuation of metoclopramide and a combination of haloperidol and isopropamide iodide in gastroenterology.


Metabolic gradients and morphological polarization in embryonic development of hydroid polypes.


Mechanism of changes in brain norepinephrine levels following olfactory bulb lesions.


Editorial. International Council of Nurses.


Posttranscriptional control in the steroid-mediated induction of hepatic tyrosine transaminase. The purine analog azaguanine does not inhibit the initial induction of hepatic tyrosine transaminase by hydrocortisone. However, the continued induced synthesis of tyrosine transaminase, elicited by repeated doses of hydro-cortisone, is inhibited approximately 64 percent in the presence of the analog after 7 to 8 hours and appears to be almost completely inhibited by 9 to 10 hours; this suggests that the induction cycle involves the activation and renewal of a pool of preexisting messenger RNA.


Stimulation of the processes of somatic embryogenesis in some Porifera and Coelenterata. 3. Effect of irradiation on the formative processes in sponges and coelenterata.


Eosinophilic leukemia. Report of five cases and review of literature.


Biosynthesis of 19-hydroxy-prostaglandin A1.


Dietary and hormonal control of enzymes of amino acid catabolism in liver.


Haematin-dependent oxidative phosphorylation in Streptococcus faecalis.


Arbovirus infections in Sarawak: observations on mosquitoes in the premonsoon period, September to December 1966.


Peebles' Rorschach content scoring system: reliability, normative data, and validity.


Cell-mediated immune responses. Report of a WHO scientific group.


Feeding and other responses of tsetse flies to man and ox and their epidemiological significance.


Possible human bartonellosis in the Sudan. Clinical and microbiological observations.


B.663 (Geigy 30. 320) in the treatment of leprosy. A preliminary report.


The distribution and ecology of Bakerocoptes cynopteri (Sarcoptiformes: Bakerocoptidae) in Malaysia.


Suppressive effect of 32'644-Ba "Ambilhar" 1-(5-nitro-2-thiazolyl-2-imidazolidinone) on experimental acute S. cruzi infection in mice.


Influence of some drugs on the accumulation of morphine in rabbit red cells in vitro.


On a successfully treated acute oral paraoxone (E 600) poisoning.


Cytochrome P-450 and drug oxidation.

Cytochrome P-450 and drug oxidation.


The influence of fasting on the metabolism of glucocorticoids in obese subjects.


Cytochrome P-450 in steroid biogenesis.

Cytochrome P-450 in steroid biogenesis.


Effects of thyroid hormones on oxidative phosphorylation and on 11beta-hydroxylation of ox adrenal-cortex mitochondria.


Fat-body lipogenesis during development of the adult male desert locust.


The metabolism of some substituted benzofuran beta-adrenergic blocking agents.


Ethanol metabolism in rats after microsomal metabolizing enzyme induction.


Fetal liver and adult thymus cells: absence of synergism in graft-versus-host reactions.


Role of ferredoxin in photosynthesis.

Role of ferredoxin in photosynthesis.


Inhibitory effects of 4-deoxypyridoxine on the endogenous activity and induction of tyrosine-alpha-ketoglutarate transaminase by cortisol.


Chlorpromazine and GABA.

Chlorpromazine and GABA.


Convulsant activity of homocysteine and other short-chain mercaptoacids: protection therefrom.


Effects of steroid and nonsteroid metabolites on enzyme conformation and pyridoxal phosphate binding.


D-amino acid oxidase in extra-embryonic membranes of the chick.


Penicillin in paranasal sinus secretions.


Differentiation of neurosensory cells in Hydra.


Removal of acid gases and oxides of nitrogen from spacecabin atmospheres. NASA CR-1388.


Recent progress in human transplantation immunology.


Action of dopamine to induce release of FSH-releasing factor (FRF) from hypothalamic tissue in vitro.


Effects of bromopyruvate on the control and catalytic properties of glutamate dehydrogenase.


North Dakota field test of cariostatic effect of 1 per cent sodium dihydrogen phosphate and disodium hydrogen phosphate added to presweetened breakfast cereals.


Nonenzymatic reduction and oxidation of myoglobin and hemoglobin by nicotinamide adenine dinucleotides and flavins.


Sodium dodecyl sulfate inactivation of bovine liver glutamate dehydrogenase.


Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharides at ehe cellular level.


Polysaccharide in delayed hypersensitivity. I. Pneumococcal polysaccharide as inducer and elicitor of delayed reactivity in guinea pigs. A highly purified pneumococcal polysaccharide (Type II SSS) is a very efficient inducer of delayed hypersensitivity in random-bred guinea pigs. The cellular reactivity induced by this polysaccharide administered subcutaneously in complete Freund's adjuvant is of "tuberculin type"; it increases in intensity with time after the sensitizing injection, as judged by skin tests, the macrophage inhibition reaction and transfer of reactivity by peritoneal exudate cells. By contrast, the cellular reactivity induced by this immunogen in the absence of mycobacterial adjuvant has the characteristics of "Jones-Mote" reactivity. It is best seen at about 1 wk after sensitization; the reactions are characteristically little indurated and show histologic differences from tuberculin type responses; and the reactive state begins to disappear by 2-3 wk, with the accession of Arthus reactivity. This type of delayed reactivity may be related to an early phase of antibody synthesis.


Effect of maternal protein deprivation on morphological and enzymatic development of neonatal rat tissue.


Rationale and indications for preoperative adrenergic receptor blockade in pheochromocytoma.


Control of degradation and synthesis of induced tyrosine aminotransferase studied in hepatoma cells in culture.


Willingness to accept limitations and personal adjustment.


The current management of paranasal sinusitis.


Note on headache, personality traits and visual performance at altitude.


The mammalian pineal as a neuroendocrine transducer.


Cell-mediated immune responses. Report of a WHO scientific group.


Tentacular and oral-disc regeneration in the sea anemone Aiptasia diaphana. II. Oxidative metabolism during wound healing and tentacular differentiation.


Cogan's syndrome treated with oral glycerine. Report of a case.


A new insight for the gastrointestinal surgeon.


Management of severe status asthmaticus.


Raising brighter children.

Raising brighter children.


Adrenal neoplasm.

Adrenal neoplasm.


History of urology in Illinois.

History of urology in Illinois.


Oral treatment of iron deficiency anemia.


Confrontation technique applied to delirium and confusional states.


Successful pregnancy in a woman with severe uremia.


The prophylactic effect of Innovar in experimental hemorrhagic shock.


The age-related susceptibility of mice to graft versus host reactions.


Some immunologic aspects of cardiac transplantation.


Isolation of a strain of Chlamydomonas reinhardi with altered control of glyceraldehyde 3-phosphate dehydrogenase.


Why the mosquito bites: a tale of blood, sweat and tears.


Adaptation of mammalian protein metabolism to amino acid supply.


Perfusion of the spleen with blood containing prostaglandin E1: transmitter liberation and uptake.


The chemical energetics of muscle contraction. I. Activation heat, heat of shortening and ATP utilization for activation-relaxation processes.


The chemical energetics of muscle contraction. II. The chemistry, efficiency and power of maximally working sartorius muscles. Appendix. Free energy and enthalpy of atp hydrolysis in the sarcoplasm.


Propranolol as an antihypertensive agent.


Diplococcus pneumoniae bacteremia.

Diplococcus pneumoniae bacteremia.


The formation of glyceryl ethers by cell-free Tetrahymena extracts.


Nicotinamide adenine dinucleotide phosphate-specific glycerol dehydrogenase of Aspergillus niger.


Some cardiovascular actions of cyclizine, chlorcyclizine and homchlorcyclizine.


Polyarteritis nodosa as a cause of perirenal and retroperitoneal hemorrhage.


Angiographic findings in polyarteritis nodosa. Report of a case.


Effect of experimental cryptorchidism and cadmium injury on the spontaneous contractions of the seminiferous tubules of the rat testis.


Studies on ACTH-induced changes at the NADP+-binding site of bovine adrenal glucose 6-phosphate dehydrogenase.


Studies of gluconeogenic mitochondrial enzymes. V. The effect of transaminases on reactions catalyzed by glutamate dehydrogenase.


Fatty acids as model systems for the action of Ricinus leaf extract on higher plant chloroplasts and algae.


The role of the phagocyte in host-parasite interactions. XIX. Leukocytic glutathione reductase and its involvement in phagocytosis.


Mutual antagonism in the metabolism of D-valine and D-leucine and antagonism by their analogs.


Alteration of centrally mediated cardiovascular manifestations by intraventricular pronethalol and phentolamine.


Noradrenaline sensitive cells in cat cerebral cortex.


The diurnal variation of urinary and plasma 17-hydroxy-corticosteroid (17-OHCS) levels and the plasma 17-OHCS response to lysine-8-vasopressin in depressive patients.


Specific determination of hydroxy groups with yeast ADH.


Frog rod outer segments, investigated by the freeze-etching technique.


A working hypothesis concerning the fine structure of the rod outer segment in the frog retina.


Reduction in the incidence of wasting disease in neonatally thymectomized CBA-W mice by the injection of thymosin.


Classification of MMPI profiles from non-psychiatric populations using two cookbook systems.


Clofibrate inhibition of 11-beta-hydroylation in bovine adrenal cortex mitochondria.


The relationship of premorbid social activity level of psychiatric patients to test performance on the WAIS and the MMPI.


MMPI "cookbook" pattern frequencies in a psychiatric unit.


A configural scoring of the MMPI and diagnosis in counseling.


Urine levels of leucine naphthylamidase (aminopeptidase) and sex chromosome abnormalities in man.


Caries experience of fifteen-year-old recruits joining the Royal Navy at HMS Ganges.


Differential distribution of cytochrome P-450 and cytochrome P-448 in liver microsomal membranes.


Growth of haemopoietic spleen colonies after grafting of human bone marrow in mice.


Ethanol-induced changes in levels of metabolites related to the redox state and ketogenesis in rat liver.


Adrenaline and the plateau phase of the cardiac action potential. Importance of Ca++, Na+ and K+ conductance.


Diaphorases and dehydrogenases during differentiation of the skeletal muscle in the chick.


Purification of ctochrome b5-ike hemoprotein from anaerobically grown yeast.


Metabolism of 3H-11-deoxycorticosterone and 4-14C-11 beta-hydroxyprogesterone by rat adrenal preparations.


Factors affecting urea inactivation of NADP-specific beta-isocitrate dehydrogenase.


Metabolism of organophosphorus insectides by liver homogenates from different species.


The ecology and control of blood-sucking ceratopogonids.


Your organization; majority-minority. The rule of the majority and the rights of the minority.


Dopa-induced excitement in the cat. Its relationship to brain norepinephrine concentrations.


Arboviruses from Saskatchewan mosquitoes--isolation of a member of the Flanders-Hart Park group and of a strain as yet unidentified.


The medical aspects of professional baseball.


Congress in Chile.

Congress in Chile.


Discussion of questions and proposals from concurrent discussion groups.


The electron microscopy of livers of mice runted as a result of the graft versus host reaction and bacterial endotoxin.


Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus.


The Prader-Willi syndrome.

The Prader-Willi syndrome. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, Associate Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


Prevention of the Arthus reaction in rats and mice by combination of epinephrine and a phenothiazine derivative, propiomazine.


Work study of a desk computer in the clinical laboratory. Calculating results from laboratory data is a time-consuming part of laboratory work, particularly in chemical pathology, and is a frequent source of mistakes. It is much less popular with technical staff than the basic laboratory work. The reasons for purchasing a desk computer, and its use to perform the calculations in a number of investigations and to convert AutoAnalyzer data into concentration units, are discussed. The introduction of a desk computer improved morale, speeded up the work, and reduced both fatigue and mistakes.


The excitatory input to a single smooth muscle cell.


Chronopotentiometry and coulometric titration of N-substituted phenothiazines.


Non-medical use of drugs with particular reference to youth.


The role of catecholamines in mepyramine resistance of anaphylactic bronchospasm in vitro.


Effects of thalidomide and chlorcyclizine on the biosynthesis of nucleic acids and proteins in fetal and maternal tissues of the rat.


Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.


Norchlorcyclizine analogs: relationship of teratogenic activity to in vitro cartilage binding.


Inhibition of the inflammatory response in the microcirculation by tourniquet shock and release of adrenal hormones. In vivo and electronmicroscopic observations.


Relationships of ATP to fatty liver: effects of adenine analogue, 4-aminopyrazolopyrimidine on lipid metabolism in rat liver.


Localization of beta-receptors in the circulatory tract.


Antibody responses to bacterial antigens during exacerbations of chronic bronchitis.


The separation of parasympatholytics by thin-layer chromatography.


The sensitizing action of Bordetella pertussis vaccine.


A protein-deficient diet. Effect on the liver, pancreas, stomach, and small intestine of the rat.


The role of the nurse in stimulating early learning.


Evaluation: a suggested method for appraising quality.


Generalizations in nursing instruction.

Generalizations in nursing instruction.


Nursing students help children express their feelings.


Knowing the learner.

Knowing the learner.


Effect of antihistaminics, trasylol and cortisone acetate on kallikrein-induced proteinuria.


Pancreatitis as an adverse reaction to salicylazosulfapyridine.


The "in vivo sensitivity test"--bacteriology of middle ear exudate, during antimicrobial therapy in otitis media.


The critically ill child: management of acute bacterial meningitis.


The management of children with epilepsy.


Psychological characteristics of psoriatics. Implications for management.


Effect of decloxizine on histamine aerosol induced bronchoconstriction in the conscious guinea-pig.


Effects of some phenothiazines on unilateral ovarian compensatory hypertrophy in the rat.


The effect of bretylium on the cardiovascular response to tyramine in the rat.


Spinach 5-phosphoribose isomerase. Purification and properties of the enzyme.


The synthesis of long-chain fatty acids by a cell-free system from Mycoplasma laidlawii A.


Centrally mediated cardiovascular and EEG responses to bradykinin and eledoisin.


Structure-activity relationship of the beta adrenoreceptor blocking agents.


The action of some agents active at autonomic ganglionic sites on the secretory response of the Heidenhain pouch to various stimuli.


Pathways for the oxidation of aromatic compounds by Azotobacter.


Empyema in children: review of mayo clinic experience.


Butaperazine and hemoglobin C trait.

Butaperazine and hemoglobin C trait.


Properties of a halophil nicotinamide--adenine dinucleotide phosphate-specific isocitrate dehydrogenase. Preliminary studies of the salt relations and kinetics of the crude enzyme. The effects of chlorides on NADP-specific isocitrate dehydrogenase from Halobacterium salinarium were investigated. The enzyme is stabilized by potassium chloride and sodium chloride and this effect is discussed in relation to the Hill (1913) equation. Kinetics of the enzyme were studied within a range of concentrations of potassium chloride and sodium chloride. Apparent Michaelis constants for both substrates were affected by salt concentration, the effect being greater in sodium chloride than in potassium chloride. Minimal apparent Michaelis constants for both substrates were similar to the corresponding constants reported for yeast isocitrate dehydrogenase. V(max.) was maximal in each salt at a concentration of about 1m. The maximum was higher in sodium chloride than in potassium chloride. At salt concentrations above about 2.3m, the apparent V(max.) was lower in sodium chloride than in potassium chloride, and at salt concentrations below 0.75-1.0m, each salt behaved as a linear activator of the enzyme. Within this concentration range salt and NADP(+) acted competitively; the activation by salt was overcome at finite concentrations of NADP(+). At concentrations above about 1m, potassium chloride was a linear non-competitive inhibitor of the enzyme. Within the range 1.0-2.5m, sodium chloride was also a linear non-competitive inhibitor, but above 2.5m it caused more pronounced inhibition.


Absence of a common intermediate pool among individual enzyme chains of the energy-conservation pathway in chloroplasts of Euglena gracilis. Tri-n-butyltin chloride is a specific inhibitor that binds stoicheiometrically and irreversibly with the ATP-synthesizing sites of chloroplasts. Titration of Euglena chloroplasts with tri-n-butyltin chloride shows about six ATP-synthesizing sites per molecule of cytochrome c(552) or per 380 molecules of chlorophyll. This system was used to study the possibility of linkage between individual enzyme chains of the energy-conservation pathway or the possible existence of a common pool of an intermediate in this pathway. The inhibition of ATP synthesis by tri-n-butyltin chloride at low rates of electron transport (low light-intensities, NADP(+) or ferricyanide as electron acceptor) agrees with a kinetic model of two to four ATP-synthesizing sites per energy-conservation chain. At high rates of electron transport, however, the results occasionally agree with a model of 20 or more sites per chain. The results are interpreted as indicating the absence of a common intermediate pool, but the presence of a limited degree of linkage between individual chains. It also indicates the presence of two energy-conservation sites in these chloroplasts.


Neurological complications of systemic diseases. II.


The therapeutic role of propranolol.

The therapeutic role of propranolol.


Receptor paralyzing agents applied in the treatment of glaucoma simplex.


Effects of 3',5'-cyclic adenosine monophosphate and its dibutyryl derivative on the motility of isolated rat ileum.


An experimental evaluation of the anticonvulsant activity of some antihistaminic drugs.


The action of sympathomimetic amines and a new beta-adrenergic blocking agent (4-(2-hydroxy-3-isopropylaminopropoxy)-indole) on the isolated trachea of guinea pigs.


Effects of enzyme inhibitors on junction potentials in response to adrenergic nerve stimulation.


Interaction of adrenaline and beta-adrenergic blocking agents on the isolated seminal vesicle of guinea pigs.


Pharmacological properties related to the mechanism of action of potent analgesic drugs.


D- and L-Alanylphosphatidylglycerols from Mycoplasma laidlawii, strain B.


Inhibition of aldobiouronates in the precipitation of pneumococcal type II and III systems.


The production, isolation, and characterization of a grisein-like sideromycin complex.


Pustular dermatoses.

Pustular dermatoses.


Preparation of an exonuclease from Lactobacillus which releases 5-mononucleotides from polynucleotides.


Quantitative estimation of thioproperazine psychomotor manifestations in schizophrenia.


On the mechanism of action of the adrenocorticotrophic hormone. The stimulation of the activity of enzymes involved in pregnenolone synthesis.


Allergic reactions to antibiotics.

Allergic reactions to antibiotics.


Polyarteritis nodosa with bilateral renal artery aneurysms and perirenal haematomas: angiographic and nephrotomographic features.


Drug-induced photosensitivity.

Drug-induced photosensitivity.


Toxic gas contaminants in enclosed environments.


Medical mistakes: misdiagnosis of nervous fatigue.


MMPI scores as related to age, educaton, and intelligence among male job applicants.


Plaque pH during and after ingestion of solid sugar.


Merodiploid ribosomal loci arising by transformation and mutation in pneumococcus. Merodiploid states have been detected in the ery and str loci of the pneumococcal genome. They are associated with particular mutations (ery-r10 and str-d2) which add to, rather than replace their homologous sites during deoxyribonucleic acid (DNA)-mediated transformation. Markers at linked sites do not become diploid at the same time. The heterozygous condition thus produced is maintained during cell reproduction. However, in the case of the ery merodiploid at least, segregation of haploid types does occasionally occur. The transforming properties of DNA isolated from the merodiploids, taken together with the segregation patterns of the merodiploids, reveal the heterozygous condition. The merodiploid condition can be transferred via a single molecule of DNA, which can be explained by assuming that both alleles at the diploid site are integrated into the linear continuity of the bacterial chromosome. In the case of the ery merodiploid, two distinct, relatively stable but interconvertible states are recognizable. Their interconvertibility, as well as the segregation of hapliod descendants, can be explained as the result of occasional pairing of the duplicated regions with loss of one of these duplicated regions by recombination.


Responses of saphenous and mesenteric veins to administration of dopamine. Others have observed that dopamine (3,4-dihydroxyphenylethylamine) constricts resistance vessels in skin, but dilates these vessels in the mesentery. We studied the effects of dopamine on cutaneous and mesenteric veins of dogs to see if this agent also produced qualitatively different effects on the tone of capacitance vessels (veins) in these vascular beds. The lateral saphenous or the left colic vein was perfused at constant flow with blood from a femoral artery. Pressures at the tip of the perfusion cannula and at the tip of a catheter 15 cm downstream were recorded continuously. Increases in the pressure gradient between these two points indicated venoconstriction; decreases indicated venodilatation. Dopamine and norepinephrine injected into the perfusion tubing caused constriction of both veins. The constriction was antagonized by blockade of alpha receptors. A dilator action of dopamine was not seen, even after alpha receptor blockade or in the presence of increased venous tone produced by serotonin, norepinephrine, or nerve stimulation. Reserpine and cocaine did not alter responses to dopamine in the saphenous vein; this suggests that the venoconstrictor action of dopamine results mainly from a direct effect on alpha receptors and that uptake into sympathetic nerve endings may not be important in regulating the amount of dopamine available to receptors in the saphenous vein.


Marihuana psychosis. A case study.

Marihuana psychosis. A case study.


Occupational differences of male psychiatric patients on the MMPI.


Increased vascular permeability produced by human platelet granule cationic extract. A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.


An emotional profile of depression.

An emotional profile of depression.


Acanthaster: a disaster?

Acanthaster: a disaster?


Blocking of beta adrenergic receptors in the urinary bladder using sotalol.


Prophylactic treatment of cluster headache with a new serotonin antagonist, BC 105.


Enzymatic properties of L-kynurenine 3-hydroxylase (EC 1.14.1.2) in Neurospora crassa.


Influence of x-irradiation on enzyme induction: phosphoenolpyruvate carboxykinase in the liver of irradiated mice.


Alpha-amanitin, a specific inhibitor of transcription by mammalian RNA-polymerase.


Transduction of Streptococcus pyogenes K 56 by temperature-sensitive mutants of the transducing phage A 25.


Separation of poliovirus specific RNA structures by analytical gelelectrophoresis.


Structural and functional changes in DNA after exposure to hydrogen atoms and gamma radiation.


Quantitative treatment of the function of plastoquinone in phostosynthesis.


Theory and techniques of personality measurement.


Geropsychology.

Geropsychology.


A simple two-step procedure for isolation of C-reactive protein.


Inhibition of the tuberculin reaction in albino rats.


Studies on denitrification. XI. Some properties of nitric oxide reductase.


NAD-dependent cytochrome b5 reduction in liver microsomes of mice.


Mechanisms of the action of propranolol and phenoxybenzamine on the coronary artery tone; an experimental study.


Group assertion training and group insight therapies.


Manifestations of cerebral arteriosclerosis unaffected by a vasodilator.


The pharmacology of SK & F 11197 (2,6 diamino-4-dimethylaminoethoxy pyrimidine), an unusual hypotensive agent. II. Mode of action studies.


On the pressor action of propranolol in the rat.


The effect of blood sugar level on the histamine-stimulated gastric secretion in shay-rats.


The effects of adrenergic drugs and blockers upon the efficiency of isotope clearance from the subcutaneous tissues of the cat.


Analysis of nicotine-induced vascular reflexes in the dog.


Combined preparation of ferredoxin, ferredoxin-NADP+ reductase and plastocyanin from spinach leaves.


Some responses of bovine intestinal musculature to humoral agents in vitro and in vivo.


Relationship between adrenergic mechanisms and the analgesic effect of sodium salicylate and mefenamic acid.


The relationship between cryptorchidism and canine testicular neoplasia.


Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme.


Thioxanthene psychopharmacological agents. I. 9-(3-aminopropyl)thioxanthene-2-sulfonamides.


Synthesis of C18- and C20-dihydrosphingosines, ketodihydrosphingosines, and ceramides by microsomal preparations from mouse brain.


Tissue culture of lizard organs.

Tissue culture of lizard organs.


Antiprotozoal quinones. II. Synthesis of 4-amino-1,2-naphthoquinones and related compounds as potential antimalarials.


Effect of H56-28 (Aptine) on catecholamine-induced arrhythmias and neuromuscular transmission in man.


Studies on the mobilization of fats in lower vertebrates.


Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.


Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat.


Osseal changes in young mice undergoing graft-versus-host reaction.


Responses to stressors of mice undergoing graft-versus-host reaction.


Comparative action of propranolol and sotalol (MJ-1999) on myocardial oxygen consumption in dogs: hemodynamic correlates.


Studies on synergistic thymus-bone marrow cell interactions in immunological responses.


Effect of adrenergic blocking agents on the vasopressin inhibiting action of norepinephrine.


Immunological studies of the Snell-Bagg pituitary dwarf mouse.


Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes.


The "malate shuttle" and control of steroid hydroxylation in the adrenal cortex.


The relation between eosinophilia, serotonin and histamine in experimental trichinellosis.


Time-dependent variations in amino acid metabolism: mechanism of the tyrosine transaminase rhythm in rat liver.


Regulation of lipolysis in cardiac muscle: a system similar to the hormone-sensitive lipase of adipose tissue.


Central neurohumoral systems involved with narcotic agonists and antagonists.


Stimulant self-administration by animals: some comparisons with opiate self-administration.


Antibodies of restricted heterogeneity for structural study.


Distribution of vasodilator nerves in the canine hindlimb.


Conditions for the formation, partial purification and assay of an inhibitor of adenosine 3',5'-monophosphate.


The glutamate dehydrogenases of yeast: extra-mitochondrial enzymes.


Properties and developmental changes of human hepatic aryl pyruvate enzymes.


Antilymphocyte serum and the induction of tolerance to transplantation antigens.


Effect of glucagon on cyclic 3',5'-AMP, phosphorylase activity and contractility of heart muscle of the rat.


Hepatic enzyme activities early in lactation: a comparison of normal and ketotic cows.


Effects of Chironex fleckeri toxin on the isolated perfused guinea pig heart.


Further studies of toxic material from nematocysts of the cubomedusan Chironex fleckeri Southcott.


Reduced triphosphopyridine nucleotide binding sites of the fatty acid synthetase of chicken liver.


Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization.


Dihydrofolate and dihydropteroate synthesis by partially purified enzynes from wild-type and sulfonamide-resistant pneumonococcus.


Symposium on cerebral and cerebellar motor control.


Microsomal cytochromes b5 and P450 during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture.


The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. 3. Effect of N-ethylmaleimide on chemical and physical properties.


The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. II. Effect of N-ethylmaleimide on kinetic properties.


Studies of thoracic duct lymphocytes of mice. II. A quantitative comparison of the capacity of thoracic duct lymphocytes and other lymphoid cells to induce graft-versus-host reactions.


Extract of Ipomoea pes-caprae (Convolvulaceae) antagonistic to histamine and jelly-fish poison.


Central sympathetic excitation caused by fluroxene.


Cardiovascular effects of fluroxene in man.


Prophylactic treatment of angina pectoris. A double-blind cross-over comparison of alprenolol and pentanitrol. Twenty-one patients with angina pectoris took part in a double-blind cross-over comparison of alprenolol (an adrenergic beta-blocker), pentanitrol (pentaerythritol tetranitrate), and placebo. Two-thirds of the patients were clinically improved on alprenolol 100 mg. four times daily, which was found to be significantly better than pentanitrol 30 mg. four times daily and placebo. There was also an indication of reduced severity of anginal attacks during alprenolol therapy. It is concluded that success in at least two-thirds can be expected with alprenolol. No serious complications or side-effects occurred during alprenolol treatment.


Antihistamines.

Antihistamines.


Adjustment, mental health opinions, and proficiency of child care personnel.


Sensation seeking, impulsivity, and psychopathic personality.


Personality characteristics of parents of neurotic, aggressive, and normal preadolescent boys.


Effect of intelligence, anxiety, and diagnosis on arithmetic and digit span performance on the WAIS.


Treatment of essential hypertension with a new vasodilator in combination with beta-adrenergic blockade.


Lymphomas in mice: failure of induction after a graft-versus-host reaction. A mild graft-versus-host reaction induced in (BALB/cJ x DBA/2J) F(1) mice by the administration of parental spleen cells that differ at several weak histocompatibility loci did not influence the development of lymphomas in these animals. Rous sarcoma virus also failed to induce tumors in the runt and control animals. Breast carcinomas, presumably due to contamination of the inoculums with mammary tumor virus, occurred in those experimental groups given parental cells, whether or not they were viable or immunologically competent. We found no evidence that the immunologic process-as represented by the graft-versus-host reaction-is causally related to the induction of neoplasia.


Effects of inhibitors of DNA synthesis on haemagglutinin and infectious SV 15 virus formation in green monkey kidney cells.


Study of the virulence of tick-borne encephalitis virus. XI. Genetic heterogeneity of the virus from naturally infectious Ixodes ricinus ticks.


Further studies on interferon and virus production in young and old cell cultures prepared from ordinary and RIF-free chick embryos.


Experimental infection of horses with A-equi 2-Miami-1-63 and human A2-Hong Kong 1-68 influenza viruses. I. The course of infection and virus recovery.


Study of the avidity of anti-influenza antibodies in sera of convalescents or subjects vaccinated with a live influenza virus vaccine.


Experimental infection of horses with A-equi 2-Miami-1-63 and human A2-Hong Kong 1-68 influenza viruses. II. Antibody response to the infection.


The role of alveolar macrophages in inhalation infection of rabbits with vaccinia virus. II. Experiments with medium and small doses of virus.


The role of alveolar macrophages in inhalation infection of rabbits with vaccinia virus. I. Experiments with large doses of virus.


Delayed hypersensitivity in vaccinia-infected mice. I. Antigen(s) responsible for developing delayed hypersensitivity.


Comparative studies on the properties of variola virus strains. I. Characteristics of chorioallantoic membrane lesions and pathogenicity for chick embryos after different methods of inoculation.


A pox-like virus in the midge Camptochironomus tentans.


Cross-neutralization studies with group C arboviruses.


"Vaccinial disease" of mice.

"Vaccinial disease" of mice.


Experimental inhalation infection of mice with venezuelan equine encephalomyelitis virus.


Coronary and hemodynamic effects of myocardio-selective beta-receptor blockade by ICI 50172 in the closed-chest dog. Differentiation of coronary and myocardial beta receptors.


Spectrophotometric assay of L-glutamic acid decarboxylase.


The effects of beta adrenoceptor blocking agents on the membrane potential and spike generation in the smooth muscle of guinea-pig taenia coli. 1. The measurement of changes in spike generation and membrane resistance in the guinea-pig taenia coli, using the sucrose gap extracellular recording method, has been shown to be a useful way to demonstrate the intrinsic sympathomimetic activity of the beta adrenoceptor blocking agents.2. Pronethalol, INPEA, MJ 1999, MJ 1998 and dichloroisoprenaline abolish the spontaneous spike discharge and produce a hyperpolarization of the cell membrane. These sympathomimetic effects were blocked by a mixture of alpha (phentolamine) and beta (propranolol) adrenoceptor blocking agents.3. Propranolol reduced the frequency of the spontaneous spike potentials but did not raise the resting membrane potential of the taenia coli.4. When the metabolism of the taenia coli was depressed, all the beta adrenoceptor blocking agents produced a depolarization of the cell membrane and sometimes initiated spike potential activity. The depolarization of the cell membrane was antagonized by superfusing the taenia coli with Krebs solution containing phentolamine. The effects of the beta adrenoceptor blocking agents were not antagonized by the presence of atropine.5. Experiments performed on the reserpinized taenia coli preparation show that depletion of the stores of catecholamines did not modify the sympathomimetic actions of the beta adrenoceptor blocking agents on the normal or metabolically depressed taenia coli preparation. The sympathomimetic action of the beta blocking agents does not appear to be mediated through the release of catecholamines within the taenia coli.


Adrenergic control of melanocytes.

Adrenergic control of melanocytes.


Effects of monoamine oxidase inhibitors and amphetamine on hypothermia produced by halothane. 1. In cats, the effects of tranylcypromine and pheniprazine, two monoamine oxidase (MAO) inhibitors with strong amphetamine-like actions, of pargyline, an inhibitor without amphetamine-like actions, and of amphetamine itself, were examined on the hypothermia produced by a 2 hr period of halothane inhalation.2. The hypothermia was prevented by intraperitoneal injections of the three MAO inhibitors. Tranylcypromine and pheniprazine acted in doses of a few milligrams, pargyline in doses of over 100 mg.3. The hypothermia was prevented by injections into the cerebral ventricles of tranylcypromine and pheniprazine, in doses which were effective also on intraperitoneal injection; intraperitoneal injections were sometimes more effective. The large doses of pargyline needed to prevent the hypothermia when injected intraperitoneally were not tested by the intraventricular route, as the injections had to be made in a volume of 0.1 ml. In smaller doses intraventricular pargyline was not effective.4. The hypothermia was prevented by an intraperitoneal or intraventricular injection of amphetamine in a dose as little as 1 mg; intraperitoneal injections were sometimes more effective.5. The effects of tranylcypromine and pargyline given intraperitoneally, and of amphetamine given intraventricularly as well, were also examined on the hypothermia produced by an intraventricular injection of 200 mug noradrenaline. The two MAO inhibitors and amphetamine prevented the hypothermia, or greatly reduced it.6. It is concluded (a) that even on intraventricular injection the MAO inhibitors must first be absorbed into the blood stream before they can prevent the hypothermia of a halothane anaesthesia; (b) that their action may not be solely on the anterior hypothalamus; and (c) that they may not act only through MAO inhibition.


Restoration of tyramine responses by bretylium, BW392C60, bethanidine and monoamine oxidase inhibitors in reserpine-treated rats. 1. Bretylium, BW392C60, bethanidine, nialamide and pheniprazine, but not guanethidine or ouabain, were all capable of restoring the cardiovascular response to tyramine in reserpine pretreated rats anaesthetized with sodium pentobarbitone.2. In parallel with their recorded in vitro activity as monoamine oxidase inhibitors, BW392C60 was found to be more potent at restoring the response to tyramine than bretylium or bethanidine.3. The restored responses to tyramine were completely blocked by desmethyl-imipramine or by a combination of phentolamine and propranolol.4. The effect of bretylium on the tyramine response was not influenced by bilateral adrenal demedullation, urethane anaesthesia, the dose or duration of the reserpine pretreatment and was not dependent upon the frequency of the tyramine injections.5. Bretylium, BW392C60 or bethanidine did not alter the pressor response to intravenous noradrenaline.6. Nialamide-induced restorations of the responses to tyramine were not further enhanced by the administration of bretylium, BW392C60 or bethanidine.7. In pithed reserpine-treated rats the ability of bretylium and BW392C60 to restore the response to tyramine was reduced.8. It is concluded that all the drugs which reversed the reserpine-induced subsensitivity to tyramine were acting as monoamine oxidase inhibitors, thus allowing the intra-neuronal accumulation of endogenously formed catecholamines. The presence of nerve impulses in the adrenergic fibres of reserpinized rats appears to be an important factor in mediating this effect.


Some pharmacodynamic properties of carrageenin in the rat. 1. Carrageenin oedema is suppressed by pre-treating the rats with cellulose sulphate, a kininogen depleting agent. This inhibition is closely related to the dose of cellulose sulphate and to the time course of kininogen depletion.2. Oedema induced by egg white or by dextran, in which the mediators are histamine and 5-hydroxytryptamine, is quite unaffected by cellulose sulphate treatment.3. Carrageenin injected intravenously lowers the arterial blood pressure of rats. This hypotensive effect is unaffected by histamine antagonists and is abolished by protease inhibitors and thus seems to be due to kinin release from plasma substrates.4. Like cellulose sulphate, carrageenin enhances the esterolytic activity of the blood from treated rats when incubated with benzoyl-arginine ethyl ester.5. The ability of carrageenin to activate the kinin-forming system could account for both its inflammatory and hypotensive effects.


Comparative actions of beta-adrenergic receptor blocking drugs on the contractile and electrical properties of isolated human atrial muscle.