Effect of catecholamines and angiotensin on extracellular water and cation movements and the effect of alpha and beta-adrenoceptor blockade. 1. The extracellular fluid volume (ECFV), as raffinose space, and its content of Na, K and Ca were measured in anaesthetized dogs in acute experiments before and during the vascular response to intravenous injections and infusions of noradrenaline, adrenaline, isoprenaline and angiotensin.2. In male dogs the effect of noradrenaline was unpredictable, the ECFV might increase or decrease. In female dogs noradrenaline caused an increase in the ECFV. The difference between the responses of the two sexes was statistically significant (P<0.001). After phentolamine, noradrenaline exerted no effect at all in either sex. After bretylium the results were like those in normal animals.3. In both males and females adrenaline generally induced an increase in the ECFV. After phentolamine, adrenaline decreased the ECFV in males and caused little change in females. The differences before and after blockade were statistically significant (P<0.001). After bretylium the results in both sexes were like those in normal animals.4. In both male and female dogs isoprenaline induced an increase in the ECFV and the results were the same as in the normal animals after both phentolamine and bretylium.5. In male dogs there was no change in the ECFV as a result of administering angiotensin, either alone or in the presence of phentolamine or bretylium. In normal females angiotensin induced a decrease in ECFV and the difference between the responses of the males and females was statistically significant (P<0.005). In females which had received either phentolamine or bretylium the results were indistinguishable from those in the males.6. Blockade of the beta-adrenoceptors with pronethalol in a few animals did not change the response to the drugs from those seen in normal animals.7. The cation content of the ECF changed in the same direction and to about the same extent as the water, except after noradrenaline when in some experiments the proportionate change in potassium concentration was considerably greater than that of the other substances.8. The inulin space and its Na and K content were measured in several dioestrous, oestrous and pro-oestrous rats and in normal and stilboestrol treated males before and after giving an intravenous injection of angiotensin. There was little difference between the results of control injections of 0.9% saline solution and of angiotensin in dioestrous and oestrous females and normal males. On the other hand, pro-oestrous females and stilboestrol treated males responded alike to angiotensin in the form of a decrease in ECFV which was statistically different from the responses in the other three groups (P<0.0005).9. It is suggested that the various results depend on two factors: the site of action of the drug-for example, whether it increases or decreases capillary pressure and therefore, fluid transfer-and also the sex of the animal. The ground substance of the small blood vessels is probably important in taking up and releasing fluid, and its capacity for so doing may well vary with the amount of available oestrogen. It appears that the effect of oestrogens and events at the alpha-adrenoceptor site are connected in some way.


Effects of beta-adrenoceptor blocking drugs on the chronotropic and inotropic actions of isoprenaline on the acutely denervated dog heart.


Effect of isoprenaline on histamine induced gastric acid secretion in dogs.


Adrenoceptors mediating metabolic responses in the greyhound.


Resistance to beta-adrenoceptor stimulants and death from bronchial asthma.


Method of studying anticonvulsant properties of drugs in man.


Effect of five beta-adrenoceptor antagonists on the effect of isoprenaline and acetylcholine on human isolated smooth muscle.


Modification of the second set reaction by antilymphocytic serum.


The effect of acute acidosis and its correction on the heart of the conscious dog.


Altered host-allograft relationships for mouse tumors modified by prior passage in vitro and in vivo.


Drug release from methyl acrylate-methyl methacrylate copolymer matrix. I. Kinetics of release.


Drug release from methyl acrylate-methyl methacrylate copolymer matrix. II. Control of release rate by exposure to acetone vapor.


Biopharmaceutical studies on 4-(aminoethanesulfonylamino)antipyrine and related compounds. I.


Biopharmaceutical studies on aminoethanesulfonylphenetidine and related compounds. II.


Some cardiac effects of beta-adrenergic stimulants in animals.


Comparative study of a new beta-adrenergic stimulant in asthma: salbutamol.


A modified screening method for estimating erythrocyte glucose-6-phosphate dehydrogenase.


An introduction to salbutamol and other modern beta-adrenoreceptor stimulants.


Training of paramedical workers and their use in the leprosy program.


The effects of oxprenolol (Trasicor, Ciba 39089-Ba) on patterns of urinary sodium excretion in man.


Control of myocardial oxygen consumption: physiologic and clinical considerations.


Treatment of hypertension.

Treatment of hypertension.


Age-dependent effects in enzyme induction--a biochemical expression of aging.


Relation of left ventricular diastolic and lung vascular pressures: atrial effects.


Role of rough and smooth microsomes in the biosynthesis of microsomal membranes.


Different turnover behavior of phenobarbital-induced and normal NADPH-cytochrome c reductases in rat liver microsomes.


Studies in planning health manpower: the Varna meeting.


Stimulation of insulin secretion by pyridine nucleotides.


Effects of age and sex on 3H-cortisol uptake, binding and metabolism in liver and on enzyme induction capacity.


Effect of cobalt and vitamin B12 on the peroxidase and iodinating activity of mouse thyroid and submaxillary gland: in vitro stimulation of vitamin B12 coenzyme on the iodination of tyrosine.


Adult homocystinuria with ectopia lentis.


Penicillin resistance of D. pneumoniae in upper respiratory infections associated with diving.


Pneumococcal bacteremia. Review of 111 cases, 1957--1969, with special reference to cases with undetermined focus.


The discovery of DNA: An ironic tale of chance, prejudice and insight.


Neonatal rise of rat liver tyrosine aminotransferase and serine dehydratase activity associated with lack of food.


Seize the new tools of medicine!

Seize the new tools of medicine!


Heterospecific transformation of Pneumococcus and Streptococcus. IV. Variations in hybrid DNA produced by recombination.


Catecholamine-independent glycogenolysis in brain during carbon monoxide poisoning.


A comparison of the effects of noradrenaline, adrenaline and some phenylephrine derivatives on alpha-, beta- and beta- adrenergic receptors.


The nematocyte complex in a Hydromedusan, Gonionemus vertens.


Regulation of tyrosine transaminase degradation in the isolated perfused rat liver by cycloheximide and insulin.


The relaxant action of ritodrine, a sympathomimetic amine, on the uterus during term labor.


Physiological implications of reduced glutathione reductase activity of red blood cells in human ariboflavinosis.


The physician's assistant.

The physician's assistant.


An emerging profession.

An emerging profession.


The physician's assistant. Exploration of the concept.


The physician's assistant. Legal considerations.


The physician's assistant. Stephen L. Joyner, P.A.


The physician's assistant. Acceptance of physician's assistants.


Nonphysician surgical assistants.

Nonphysician surgical assistants.


High dihydrofolate reductase levels in Diplococcus pneumoniae after mutation in the structural gene: biochemical and immunological evidence for increased synthesis. A unique class of missense mutations in the dihydrofolate reductase structural gene of Diplococcus pneumoniae determines marked increases in the corresponding enzyme activity. Immunological evidence, based on precipitating and neutralizing antibody reactions, is presented in support of previously derived findings which attribute this increase in activity to an increase in the amount of enzyme protein. Biochemical evidence was obtained which shows that the increased amounts of dihydrofolate reductase protein in the mutants not owing to a decrease in degradation, reducing turnover, or to an increase in stability, and, therefore, probably related to an increase in the rate of synthesis of new protein. The manner in which a missense alteration of a structural gene might quantitatively alter the expression of that gene is discussed.


Purification, properties, and regulation of glutamic dehydrogenase of Bacillus licheniformis. Cell-free extracts of Bacillus licheniformis and B. cereus were found to contain high specific activities of nicotinamide adenine dinucleotide phosphate (NADP)-dependent-l-glutamate dehydrogenase [EC 1.4.1.4; l-glutamate: NADP oxidoreductase (deaminating)]. Maximum specific activities were found in extracts of cells during the late exponential phase of growth when ammonium ion served as the sole source of nitrogen. Extremely low specific activities were detected throughout the growth cycle when l-glutamate or Casamino Acids served as the source of carbon and nitrogen. The enzyme was purified 55-fold from crude extracts of B. licheniformis, and apparent kinetic constants were determined. Sigmoidal saturation kinetics were not observed, and various adenylates had no effect on the enzyme. Repression of enzyme synthesis during growth on l-glutamate or Casamino Acids was partially overcome by additions of glucose or pyruvate, and this apparent derepression was totally abolished by inhibitors of ribonucleic acid and protein synthesis. Similarly, additions of l-glutamate or Casamino Acids to cells growing on glucose-ammonium ion resulted in strong repression of enzyme synthesis. It is suggested that the enzyme serves an anabolic role in metabolism. Nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase activity was not detected in five species of Bacillus, irrespective of nutritional conditions or of the physiological age of cells.


Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures.


Inhibitory effects and metabolism of 5-fluoropyrimidine derivatives in pneumococcus. 5-Fluorouracil (FU), 5-fluorocytosine, and the riboside and deoxyriboside derivatives of these fluoropyrimidines each exhibit a different spectrum of inhibitory effects in pneumococci. The biochemical basis of this finding seems to be the extremely low level of nucleoside phosphorylase (hydrolase) and N-trans-deoxyribosylase activity in pneumococcus and the consequent, relatively limited metabolic interconversion of the different fluoropyrimidines, which can therefore selectively affect one or the other of the several drug-sensitive biochemical reactions in this bacterium. Special attention was paid to the effect of fluoropyrimidines on the metabolism of cytosine and thymidine. In spite of the fact that FU is converted to both fluorouridine triphosphate and fluorocytidine triphosphate, only fluorouridylate but no fluorocytidylate can be detected in the ribonucleic acid Exogenous FU and fluorouridine also inhibit the synthesis of cytosine nucleotides from supplied uridine in a pyrimidine auxotroph. Thymidine was found to be a poor reversing agent for any of the fluoropyrimidine inhibitions. In both the wild type and in a thymidine-requiring (thymidylate-synthetase deficient) mutant, growing with supplied thymidine in the medium, fluorodeoxyuridine (FUdR) treatment caused cell death and inhibition of the incorporation of radioactive thymidine, adenosine, or uracil into deoxyribonucleic acid. It is suggested that FUdR (or a metabolic derivative) inhibits the transport of phosphorylation of thymidine in this microorganism.


Mechanism for regulating the distribution of glucose carbon between the Embden-Meyerhof and hexose-monophosphate pathways in Streptococcus faecalis. Glucose-adapted Streptococcus faecalis produced little if any (14)CO(2) from glucose-1-(14)C, although high levels of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (EC 1.1.1.44) were detected in cell-free extracts. Metabolism of glucose through the oxidative portion of the hexose-monophosphate pathway was shown to be regulated in this organism by the specific inhibitory interaction of the Embden-Meyerhof intermediate, fructose-1, 6-diphosphate (FDP), with 6-phosphogluconate dehydrogenase. Glucose-6-phosphate dehydrogenase activity was unaffected by FDP. The S. faecalis 6-phosphogluconate dehydrogenase was partially purified from crude extracts by standard fractionation procedures and certain kinetic parameters of the FDP-mediated inhibition were investigated. The negative effector was shown to cause a decrease in V(max) and an increase in the apparent K(m) for both 6-phosphogluconate and nicotinamide adenine dinucleotide phosphate (NADP). These effects were apparently a consequence of the ligand interacting with the enzyme at a site distinct from either the substrate or the coenzyme sites. Among the evidence supporting this was the fact that beta-mercaptoethanol blocked completely FDP inhibition, but had no effect on catalytic activity. The possibility that the regulation of 6-phosphogluconate dehydrogenase activity by FDP might be of some general significance was suggested by the observation that this enzyme from several other sources was also sensitive to FDP.


The effect of monoamines upon rat uterus contractility after blockade of adrenergic system receptors.


Purification and properties of alpha-ketoglutarate reductase from Micrococcus aerogenes. Micrococcus aerogenes grown in media containing glutamate has high levels of glutamate dehydrogenase and alpha-ketoglutarate reductase. The latter enzyme catalyzes the reversible reduction of alpha-ketoglutarate to alpha-hydroxyglutarate in the presence of reduced nicotinamide adenine dinucleotide (NADH). The enzyme has a high specificity for both substrates in either direction and displays Michaelis-Menten kinetics at moderate substrate concentrations. K(m) values of 0.12 to 0.17 mm alpha-ketoglutarate and 0.3 mm NADH for the forward reaction were calculated from data obtained at low substrate concentrations. At high concentrations, this reaction was inhibited by both substrates. The reverse reaction, which proceeded at 0.1 to 0.2 times the rate of the forward reactions, was inhibited by one of the products, alpha-ketoglutarate. K(m) values for the substrates of this reaction were 10 mm for alpha-hydroxyglutarate and 1 mm for nicotinamide adenine dinucleotide. alpha-Ketoglutarate reductase has a molecular weight of 7.5 x 10(4) to 8.2 x 10(4) and is composed of identical polypeptide chains with a molecular weight of 3.6 x 10(4) to 3.8 x 10(4).


Calcium: is it required for transmitter secretion? Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.


The Alderson-Broaddus college program for the physician's assistant.


Interconversion of the multiple forms of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.


Canada's first conference on research in nursing practice.


The National Medicolegal Symposium.

The National Medicolegal Symposium.


Significance of serum N-acetyl-beta-D-glucosaminidase in tissue rejection.


Differential inactivation of lymphocytes and bone marrow stem cells by heterologous anti-mouse gamma-globulin serum.


Suppression of graft versus host reaction by univalent anti-immunoglobulin antibody.


Allogeneic bone marrow transplantation in irradiated baboons and monkeys.


Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras.


The prompt detection of ionizing radiations by a marine coelenterate.


Relationship between age and properties of human erythrocyte glutathione reductase.


The effect of habitual toothcleansing on the occurrence of periodontal disease and dental caries.


Periodic mass treatment with diethylcarbamazine for the control of filariasis in American Samoa. Filariasis surveys made during 1962-63 in 5 villages in American Samoa among persons over 5 years of age gave an elephantiasis rate of 3.4%, a microfilarial rate of 26% and a median microfilarial rate (MfD(50)) of 29. These rates were somewhat higher than those found in surveys made in the same villages among villagers of the same ages some 20 years previously. A mass treatment programme with diethylcarbamazine was then decided on.Preliminary treatment with a single total regimen of 72 mg of the drug per kg of body weight, given in 12 doses of 6 mg/kg, was administered in several villages over a period of 6 months. Among villagers of all ages at the end of 3 years, the microfilarial rate was 7.3% and the MfD(50) value was 2. These results appeared to be inadequate for a successful control programme and a periodic mass treatment project of 2 or more regimens of 72 mg/kg to be administered every 2 years was instituted on the Island of Tutuila, to be continued until considered no longer necessary.Surveys made 2 years after the second mass treatment in the villages of Amouli, Amanave, Onenoa, Tula, Alao, Utumea and Alofau, in which 1407 persons were examined, showed that 3 villages were negative for microfilariae, that the average microfilarial rate in all 7 villages was 0.4% and that the MfD(50) was 1. These villages were also negative in intensive mosquito surveys for infective-stage larvae of Wuchereria bancrofti. It is suggested that interruption of transmission has been observed in the 3 villages negative for both microfilariae and infective-stage larvae and that, if favourable surveys continue, eradication programmes should be established.


Comparative immunology: the hemolytic complement system of the anuran amphibian, Bufo marinus.


Carbon dioxide anesthesia of the face fly, Musca autumnalis De Geer: effects of temperature and oxygen on knockdown rate.


Ultrastructure of the ventricular tissue of the hibernating ground squirrel, Citellus lateralis, in relation to the physiology of the hibernator's heart.


Ion fluxes across normal and diamox-treated brook trout gas bladders.


Thermoregulation and water relations of two East African antelopes: the hartebeest and impala.


Serine metabolism in the culture form of Trypanosoma cruzi: distribution of 14C from serine into metabolic fractions.


Antibody formation in hedgehogs. II. Hibernating animals.


Metabolism of inorganic cations by quail (Coturnix coturnix) drinking solutions of CaCl2 and MgCl2.


Diurnal fluctuation in DNA content and DNA synthesis in the dorsal epidermis of Rana pipiens.


Regional variation in the aerobic metabolism of intestinal mucous membrane.


Cutaneous and respiratory evaporation in the painted quail, Excalfactoria chinensis, during ontogeny of thermoregulation.


Comparative studies of lens alpha-crystallin from eight species.


Homeostasis during hibernation in the golden-mantled ground squirrel, Citellus lateralis.


Topographic correspondence among electrographic pattern, water and electrolytes in the toad brain.


The effect of artificial cryptorchidism on the testis and on testicular blood flow in an Australian marsupial, Macropus eugenii.


Respiration of the avian aorta in relation to spontaneous atherosclerosis.


Potential differences and short circuit current across the skin of Rana cancrivora, in vitro.


Oxygen consumption of tree shrews: effects of ambient temperatures.


Localization of an insoluble excretory product in Cephalogonimus americanus (Trematoda).


Oxidation-reduction potentials of D-amino acid oxidase.


"In situ" visualization of a graft-vs-host reaction.


The response in rabbits to prolonged immunization with type 3 pneumococci.


Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase.


Therapeutic abortion follow-up study.

Therapeutic abortion follow-up study. To determine the long-range psychological effects of therapeutic abortion, 50 women (aged from 13-44 years), who were granted abortions between 1967 and 1968 Because of possible impairment of mental and/or physical health, were analyzed by  use of demographic questionnaires, psychological tests, and interviews.  Testing revealed that 44 women had psychiatric problems at time of abortion.  43 patients were followed for 3-6 months.  The follow-up interviews revealed that 29 patients reacted positively after abortion, 10 reported no significant change and 4 reacted negatively.  37 would definitely repeat the abortion.  Women under 21 years of age felt substantially more ambivalent and guilty than older patients.  A study of 36 paired pre- and post-abortion profiles showed that 15 initially abnormal tests had become normal.  There was a significant increase in contraceptive use among the patients after the abortion, but 4 again became pregnant and 8 were apparently without consistent contraception.  It is concluded that the abortions were therapeutic, but physicians are encouraged to be aware of psychological problems in abortion cases.  Strong psychological and contraceptive counselling should be exercised.


Cholinergic regulation of hepatic tyrosine transaminase activity. 1. The cholinergic agent carbachol (0.5 mg/kg) produces within 2 hr a two- to threefold increase in the activity of hepatic tyrosine transaminase in the adrenalectomized fasted rat.2. The carbachol-evoked rise in enzyme activity is prevented by pretreatment with atropine.3. Cycloheximide, an inhibitor of protein synthesis, prevents the carbachol-evoked rise of enzyme activity; actinomycin D, an inhibitor of RNA synthesis, partially reduces it.4. Atropine or unilateral (right or left) vagotomy suppresses the daily rhythm of tyrosine transaminase by attenuating the normal evening peak but not the normal lower daily levels of the enzyme.5. Electrical stimulation of the right vagus results in a significant elevation of tyrosine transaminase activity within 2 hr.6. The observations suggest that activity of vagal cholinergic nerves produces an RNA-dependent induction of hepatic tyrosine transaminase through a process requiring cholinergic-receptor stimulation. Intermittent activity of this vagal cholinergic system may contribute to the regulation of the daily rhythm in this enzyme.


Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder.


A histologic evaluation of cartilage homograft implant used in preprosthetic surgery.


The electron transport system in nitrogen fixation by azotobacter. 3. Requirements for NADPH-supported nitrogenase activity.


Early stages of spermatozoan development in the colonial hydroid Campanularia flexuosa.


The acceptor specificity of flavins and flavoproteins. 3. Flavoproteins.


On two photoreactions in system II of plant photosynthesis.


Effects of monovalent cations on light energy distribution between two pigment systems of photosynthesis in isolated spinach chloroplasts.


On the siteof action of plastocyanin in isolated chloroplasts.


Haemodynamic effects of beta-receptor blocking drugs during nitrous oxide-halothane anaesthesia.


Cardiovascular effects of pancuronium in man.


Significance of the pulmonary wedge pressure measurement in man.


Preliminary studies of the pharmacological effects of 5-[1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)-ethyl] salicylamide (AH 5158) in man.


The selective uptake of mercury by myocardial infarcts in the rat.


The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine.


The sizing of some powder and liquid sprays from pressurized packs by air sedimentation.


Dissolution rate studies using the B.P. disintegration apparatus.


Non-competitive spasmolytics as antagonists of Ca++-induced smooth muscle contraction.


NOR2 chlorpromazine sulphoxide, a "pink spot" produced in vivo and in vitro from chlorpromazine.


Pharmacological studies of fluphenazine and nortriptyline in combination in man.


Promethazine on hand-eye co-ordination and visual function.


Brain acetylcholine and monoamines during experimental catatonia.


Effect of cholinergic drugs on the somatosensory evoked potentials.


Inhibition by appetite suppressants of the pressor response to (+)-amphetamine in anaesthetized cats.


Modification by a tricyclic series of compounds of the noradrenaline effect on the cat nictitating membrane.


A modified competitive protein binding method for measuring plasma progesterone levels.


A quick method for testing antituberculosis drugs.


The effects of anti-inflammatory drugs on the protein-binding of [1,2-3H] cortisol in human plasma in vitro.


Interactions in phenol-sodium dodecyl sulphate-water systems.


Absorption of some organic compounds from the biliary system of the rat.


Differences in the stereospecificity of closely related compounds; a reinvestigation of the enantiomers of procyclidine, benzhexol and their metho- and etho-salts.


The recovery of noradrenaline in adrenergic nerve terminals of the rat after reserpine treatment.


The action of isoprenaline on the perfused vessels of the rabbit ear.


The protective effect of gallate antioxidants on emulsions and solutions of benzaldehyde.


Effects of acetylsalicylic acid on serum protein binding and metabolism of tryptophan in man.


The identification, isolation, and preservation of delta-9-tetrahydrocannabinol (delta-9-THC).


Mass spectrometry of fluorinated corticosteroidal 1,4-dien-3-ones of the British Pharmacopoeia.


The role of cyclic AMP in isoprenaline-induced cardiac necroses in the rat.


The effect of thymoxamine on peripheral blood vessels as monitored by the 133Xe clearance technique.


Mechanism of MJ 1999-induced blockade of neuromuscular transmission.


A note on the assay of atropine sulphate injections.


The preferred conformation of noradrenaline.


A simple method for the quantitative extraction of dye extravasated into the skin.


The inducement of tone and its inhibition in isolated tracheal muscle.


Atropine-resistance of the urinary bladder innervation.


Further studies on the mechanism of the central hypotensive effect of L-dopa, DL-m-tyrosine and L-alpha-methyldopa.


Metabolic degradation of prostaglandin E1 in the rat plasma and in rat brain, heart, lung, kidney and testicle homogenates.


Emulsion stabilization by non-ionic surfactants: experiment and theory.


The effect of heat, pH and some buffer materials on the hydrolytic degradation of sulphacetamide in aqueous solution.


Modifications of the responses to antidiuretic hormone by hydrolytic enzymes.


Demonstration of 3,4-dihydroxy(14C)benzoic acid and (14C)vanillic acid after administration of (14C)noradrenaline in the rat.


Uptake and metabolism of beta-phenethylamine and tyramine in mouse brain and heart slices.


The spontaneous electrical and mechanical activity of the longitudinal smooth muscle of the rabbit duodenum and its modification by drugs and temperature changes.


The metabolism and urinary excretion in man of phentermine, and the influence of N-methyl and p-chloro-substitution.


The influence of hypothermia on chlorpromazine-induced metabolic changes in mouse heart and brain.


Blocking of reticuloendothelial cells by dextran.


Effects of small doses of haloperidol on timing behavior.


Role of L-ascorbic acid in the reversal of the monoamine oxidase inhibition by caffeine.


The significance of the relative potencies of norepinephrine and alpha-methylnoradrenaline for the mode of action of alpha-methyldopa.


Marihuana: importance of the route of administration.


Injectible dispersion of delta 9-tetrahydrocannabinol in saline using polyvinylpyrrolidone.


The temperature dependence of the critical micelle concentrations cationic surface-active agents.


The mechanism of small intestinal villous movement in the pigeon.


Contraction and membrane activation in several mammalian vascular muscles.


Partial purification by affinity chromatography of tyrosine aminotransferase-synthesizing ribosomes from hepatoma tissue culture cells. This report describes a cell-free protein-synthesizing system derived from hepatoma tissue culture cells in which the synthesis of tyrosine aminotransferase is enhanced in relation to total protein synthesis. The enhancement was achieved by using affinity chromatography to select a specific fraction of ribosomes in which the proportion of tyrosine aminotransferase synthesis is higher than it is in unfractionated ribosomes.


Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells. Kinetic and equilibrium studies are presented for the reversible binding of [(3)H]dexamethasone by "specific" macromolecular receptors in the cytoplasmic fraction of cultured rat hepatoma cells. As in the case of the nuclear receptors in the same cells, the binding affinities of various steroids for the cytoplasmic receptors are closely correlated with the activities of these compounds as inducers of both tyrosine aminotransferase (EC 2.6.1.5) and cell adhesiveness. This suggests that the binding reaction is important for the biological effects of the hormones. Steroid-binding activity is inhibited by various proteases, mercurials, and 1 M KCl, but not by DNase or RNase. The receptors sediment in sucrose gradients in 0.5 M KCl near 4S, and at lower ionic strength near 7S; some of their physical properties are altered upon binding steroid. Bound dexamethasone can be recovered from the receptors as the unaltered steroid.


The hepatic outflow tract in dogs.

The hepatic outflow tract in dogs.


Demonstration of imino acids as products of the reactions catalyzed by D- and L-amino acid oxidases. It had long been thought, but never demonstrated, that imino acids are formed in the reactions catalyzed by D- and L-amino acid oxidases (EC 1.4.3.3 and 1.4.3.2). The formation of imino acids is now shown directly by allowing the amino acid oxidase reaction to proceed in the presence of NaBH(4), when the imino acid is reduced to the corresponding racemic amino acid. Thus, when NaBH(4) is added to a mixture of D-amino acid oxidase and D-alanine, a significant amount of L-alanine is formed. Analogous results are obtained using L-amino acid oxidase and L-leucine. Since D-amino acid oxidase is active in the presence of NaBH(4), L-alanine continues to be formed until most of the D-isomer is oxidized by the enzyme. This reaction provides a new method for inverting the configuration of an amino acid. When NaBH(4) is added to a system containing D-amino acid oxidase plus D-alanine and L-lysine, free epsilon-N-(1-carboxyethyl)-L-lysine is formed. When bovine serum albumin is substituted for L-lysine, the same compound results upon acid hydrolysis. It is concluded that the amino acid oxidase reaction produces a free imino acid, which may be reduced by NaBH(4) to a racemic amino acid or may form Schiff's bases by reaction with the epsilon-amino groups of proteins and of free lysine.


The antiallergy properties of U-17,660, a dibenzodiazepine.


The ability of Schizosaccharomyces acidodevoratus to utilize some acids of the Krebs cycle.


Cardiovascular effects of equi-antiarrhythmic doses of alprenolol (a beta-adrenergic receptor antagonist) diphenylhydantoin and procainamide.


Anti-arrhythmic drugs and maximum driving frequency of isolated guinea-pig auricles.


Effects of x-irradiation on the various enzymic functions of NADP plus-linked isocitrate dehydrogenase.


Role of the lungs in the metabolism of circulating hormones.


Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood cells.


The patent omphalomesenteric duct.

The patent omphalomesenteric duct.


Independent council on continuing medical education: a progress report.


EKG of the month.

EKG of the month.


Carcinoma in perforated diverticulum of the colon.


The view box.

The view box.


Management of the patient with terminal illness.


Monitoring of intrathecal polymyxin B dosage during treatment of pseudomonas meningitis.


"DN PERFORMING IVs dispensing medications.


Gardner's syndrome. A variant of congenital familial polyps.


Calling for the prevention of aquatic accidents.


"Caution--living may be hazardous".

"Caution--living may be hazardous".


Positive mental attitude a "must" for us.


Mechanism responsible for release of toxin by Metarrhizium spores in mosquito larvae.


Enzymes of Trichophyton rubrum.

Enzymes of Trichophyton rubrum.


Absorption of alprenolol in man from tablets with different rates of release.


Anti-arrhythmic effect of DL-propranolol, D-propranolol and I. C. I. 50 172 in experimental myocardial infarction in the dog.


Isolation and study of Sumakh virus, a member of the Uukuniemi group, in the U.S.S.R.


The role of topical medications in the management of stasis ulcers.


Traumatic disruption of the developing incisor in rats.


Treatment of anaphylactic shock.

Treatment of anaphylactic shock.


Acute poisoning: some myths and misconceptions.


Oral health in Guatemalan rural populations.


The technology of automated multiphasic health testing (AMHT). Davos, Switzerland, September 14-18, 1970.


Action of thymoxamine on mydriasis induced by levodopa and dopamine. Eye-drops of levodopa and dopamine induce pupillary dilatation which is inhibited by thymoxamine, an alpha-adrenergic blocking drug. This indicates that the mydriatic action of levodopa and dopamine involves excitation of alpha-adrenergic receptors of the dilator pupillae muscle. Such a conclusion is in accord with the previously expressed suggestion that levodopa is rapidly converted to dopamine, which displaces noradrenaline from adrenergic nerve endings.The findings that dopamine exerts alpha-adrenergic effects at the periphery may be construed as evidence in support of the view that the hypotensive action of levodopa is mediated via the central nervous system.


Bacterial genome sizes determined by DNA renaturation studies.


Immunocompetent cells among mouse thymocytes: a minor population. Suspensions prepared from thymuses of TL(+) mice contain a majority of TL(+) cells and a minority of TL(-) cells. The graft versus host reactivity of the TL(-) population is much greater than that of the whole population, as judged by the numbers of cells required to give splenic enlargements in Simonsen's assay. It is proposed that the TL(-) thymocyte represents a stage in the differentiation of TL(+) thymocytes into immunocompetent lymphocytes.


The pharmacology of the normal and diseased heart in relation to cardiac surgery.


Myocardial and haemodynamic effects of phentolamine. 1. In cats anaesthetized with pentobarbitone, intravenous infusions of phentolamine ((10-50 mug/kg)/min for 5 min) increased heart rate, left ventricular dp/dt max (without increasing end-diastolic pressure), aortic dp/dt, cardiac output, myocardial blood flow and metabolic heat production.2. Phentolamine-induced increases in myocardial contractility occurred irrespective of the direction or magnitude of the blood pressure change and were maintained well beyond the actual infusion period.3. In cats treated with alprenolol, bretylium or reserpine there was no evidence of increased cardiac contractility following phentolamine administration.4. It is concluded that phentolamine, in doses less than those required to produce significant alpha-adrenoceptor blockade, increased myocardial contractility through an effect on the sympathetic nervous system.


Distribution kinetics and intestinal absorption of practolol in the rat. 1. After intravenous injection of practolol the blood concentration-time curve is fitted by a bi-exponential function. A two compartment open system model is therefore a minimal requirement in order to describe adequately the distribution of the drug in the body.2. The parameters of the two compartment model for practolol were determined. The mean values for the ;fast disposition' half life and the ;slow disposition' half life were 0.5 min and 13.3 min, respectively.3. The rate constants of distribution and elimination were similar in different animals. The volume of the central compartment was related to the weight of the animal.4. The absorption of practolol from an intestinal site was measured by its appearance in the blood. The rate constant for this process was estimated to be 0.03 min(-1).


Spasmolytic effects of cadmium and zinc ions upon the guinea-pig isolated ileum preparation. 1. An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents.2. Radioisotope studies showed that cadmium and zinc ions have very much larger apparent volumes of distribution than sorbitol, both within whole ileum and within strips of the longitudinal smooth muscle layer. The results of these studies were indicative of surface binding and/or intracellular accumulation of these ions.3. It is suggested that cadmium and zinc ions directly depress smooth muscle contractility in a non-specific manner. This action may result from their binding to or accumulation within the muscle cells.


The effect of solvents on the potency of chlordiazepoxide, diazepam, medazepam and nitrazepam.


The reversal of phenoxybenzamine-produced alpha-adrenoceptor blockade by the isomers of propranolol and INPEA.


Electron transport and oxidative phosphorylation in the blue-green alga Anabaena variabilis.


The enzymatic degradation of hemoglobin to bile pigments by macrophages. Recent studies have identified and characterized the enzymatic mechanism by which hemoglobin-heme is converted to bilirubin. Under physiologic conditions the enzyme system, microsomal heme-oxygenase, is most active in the spleen followed by the liver and bone marrow, all of which are tissues that normally are involved in the sequestration and metabolism of red cells. Indirect evidence suggested that the reticuloendothelial system is important in this process. To test this hypothesis, conversion of heme to bilirubin was studied in macrophages obtained by chemical or immunological means from the peritoneal cavity or from the lungs of rodents. Homogenates of pure populations of these cells were devoid of heme-oxygenase activity, unless before harvesting the macrophages had been exposed to methemalbumin, microcrystalline hemin, or hemoglobin in vivo. In macrophages exposed to heme pigments, the specific activity of heme-oxygenase was far in excess of that in the spleen or liver. Enzyme activity was also present in the granulomatous tissue surrounding subcutaneous hematomas. The heme-oxygenase system in macrophages resembles that in the spleen and liver in that it is localized in the microsomal fraction, has an absolute requirement for molecular oxygen and NADPH, is inhibited by carbon monoxide, and has a similar K(m). These findings indicate that cells of the reticuloendothelial system, presumably including the Kupffer cells of the liver and the macrophages of the spleen, possess the enzymatic machinery for converting hemoglobin-heme to bilirubin. The reaction is a mixed function oxidation, probably involving cytochrome P450 as the terminal oxidase. Enzyme activity in macrophages is capable of regulatory adaptation in response to substrate loads. In the standard assay system for the enzyme, disappearance of heme always was in excess of the amount of bilirubin formed, suggesting the simultaneous presence of alternate routes of heme degradation not involving bilirubin as an end product or intermediate.


Mechanism of the inhibitory action of indomethacin on smooth muscle. 1. Strips of muscle from the wall of the guinea-pig stomach contracted in response to electrical field stimulation (100 ms pulses, 0.2 Hz) or to histamine (1 mug/ml), and these responses were inhibited by indomethacin (2-20 mg/100 ml).2. Glycerol-extracted strips of stomach muscle developed tension when exposed to a mixture of ATP, CP, magnesium chloride and calcium chloride. The tension response was not altered by indomethacin (50 mg/100 ml).3. Indomethacin failed to alter the content of ATP or of CP in strips of stomach muscle.4. The calcium content of strips of stomach muscle increased in response to 30 min of electrical stimulation (100 ms pulses, 0.2 Hz). The uptake of calcium and the contraction of the strips were inhibited by indomethacin (2-20 mg/100 ml) to a similar extent.5. Calcium uptake by electrically stimulated guinea-pig aorta was inhibited by lower concentrations of indomethacin than were required by stomach muscle.


[The oestrogenic and anti-oestrogenic properties of ring methyl-substituted stilboestrols].


Identification and quantitative determination of some metabolites of methadone, isomethadone and normethadone.


The distribution of methadone in man.

The distribution of methadone in man.


A note on the influence of diet in West Africa on urinary pH and excretion of amphetamine in man.


The binding of bupivacaine to maternal and foetal plasma proteins.


Decomposition of methoxamine in aqueous solution: identification of the decomposition products.


Structural differences in solutions derived from polymorphic modifications of aspirin.


A reduced rate of turnover of brain noradrenaline during pentobarbitone anaesthesia.


In vivo electrically evoked release of [3H]noradrenaline from cat brain.


On the positive inotropic action of glucagon in the isolated atria of the guinea-pig.


Inhibitory action of gamma-aminobutyric acid on cryoepilepsy in the frog.


Increase of blood-brain barrier permeability to catecholamines by dimethyl sulphoxide in the neonate chick.


Inhibition of choline acetyltransferase and hexobarbitone-metabolizing enzymes by naphthylvinyl pyridine analogues.


The involvement of plasma free fatty acids in (+)-amphetamine-induced hyperthermia in rats.


Genetic control of adjuvant-induced arthritis in rats.


An apparatus for facilitating the measurement of tracer movements in a large number of muscle strips.


Multiple adenomatosis presenting with psychiatric manifestations.


Further studies on the biochemistry of the toxins from the sea wasp Chironex fleckeri.


Toxicity and some enzymatic properties and activities in the venoms of Crotalidae, Elapidae and Viperidae.


Effects on bacterial transformation of single-strand breaks in DNA produced by deoxyribonuclease I and gamma rays.


A simplified method of determining a population's needs for dental treatment.


Enzyme regulation, lysine pathways and cell wall structures as indicators of major lines of evolution in fungi.


Two-stage orchiopexy.

Two-stage orchiopexy.


Effect of glucagon on the level of adenosine 3',5'-monophosphate in rat liver: dependence on the route of administration.


Conversion of testosterone to androstenedione by the nuclear fraction of pig liver.


A comparative study on the antihistaminic potencies of promethazine hydrochloride, mepyramine maleate and pheniramine maleate in dogs.


Experimental modification of the sleep-induced peak of growth hormone secretion.


Infantile periarteritis nodosa with coronary and brachial aneurysms: a case diagnosed during life.


Physician productivity and medical care.


Interstitial cystitis: treatment by transurethral resection.


Enhancement of tumour homografts by the local graft-versus-host reaction.


Altered immunogenicity of the allogeneic spleen cell preparations from rats affected by the graft-versus-host reaction.


Four years' experience with cadaveric renal transplantation.


Primary influenzal pneumonia.

Primary influenzal pneumonia.


Acute anaphylactic reactions and aspirin allergy.


A comparison of the proteolytic susceptibility of several rat liver enzymes.


Electron transport and progesterone biosynthesis in the bovine corpus luteum homogenate.


Neural mechanism of the relaxing responses of guinea-pig taenia coli.


Photosynthetic control in isolated spinach chloroplasts with endogenous and artificial electron acceptors.


The effects of mianserin hydrochloride on the vascular responses evoked by 5-hydroxytryptamine and related vasoactive substances.


Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.


Effect of some beta-adrenoreceptor blocking agents on the uptake of noradrenaline by adrenergic nerves in the nicititating membrane of the pithed cat.


High nutrition-low cost foods: their impact in developing countries.


A quasi-paranoid feature of students' extreme attitudes againstcolonialism.


Purpose-in-life test: further correlates.


Undernutrition in the neonate: long-term effects upon mitochondrial and microsomal constituents of the rat hepatocyte.


White-light three dimensional microscopy using multiple-image storing and decoding.


Metabolism of progesterone by the rat ovary: formation of 3-beta-hydroxy-5-alpha-pregnan-20-one by ovarian microsomes.


Lung puncture-aspiration as a bacteriologic diagnostic procedure in acute pneumonias of infants and children.


The immune response of allergic and normal subjects to pneumococcal polysaccharide.


Variation in the development of cellular immune reactivity of thymus cells and spleen cells in young inbred mice.


Genetic diversity of the "Mediterranean" glucose-6-phosphate dehydrogenase deficiency phenotype. Genetic diversity of the "Mediterranean" phenotype of G-6-PD (glucose-6-phosphate dehydrogenase) deficiency was revealed when detailed studies were performed on blood specimens from 79 Greek males with G-6-PD levels 0-10% of normal. Four different mutants were found to be responsible for the severely deficient phenotypes: two mutants. G-6-PD U-M (Union-Markham) and G-6-PD Orchomenos, were distinguishable by electrophoresis, while the other two. G-6-PD Athens-like and G-6-PD Mediterranean, were distinguishable on the basis of their kinetic characteristics. Of the kinetic tests applied, the most useful for differentiating the variants were those measuring utilization rates of the analogue substrates deamino-NADP, 2-deoxyglucose-6-phosphate, and galactose-6-phosphate. Among unrelated males with severe G-6-PD deficiency, the relative frequencies of the four variants were: G-6-PD U-M. 5%; G-6-PD Orchomenos, 7%; G-6-PD Athens-like, 16%; G-6-PD Mediterranean, 72%. Genetic, biochemical, and clinical implications of the findings are discussed.


The role of podiatry.

The role of podiatry.


Observations on the treatment of colitis.


Local graft-versus-host reaction in rats as a clinical assay of immunosuppression.


Hydroxylation of aliphatic compounds by liver microsomes. 3. Model hydroxylation reactions.


Optical measurements of the rapid pH-change in the visual process during the metarhodopsin I-II reaction.


Direct and abscopal antitumor action of local hyperthermia.


Effect of lb 46, a new beta-adrenergic antagonist, in hyperthyroidism. Heart rate and blood pressure at rest and during exercise.


Beta-adrenergic blockade in the treatment of left-sided hypertrophic obstructive cardiomyopathy (HOCM).


Clinical and radiologic improvement of regional enteritis and enterocolitis after treatment with salicylazosulfapyridine.


Peroxidative metabolism in alveolar macrophages.


The influence of pH and methylene blue on the pathways of glucose utilization and lactate formation in erythrocytes of man.


Methionine metabolism and cephalosporin C synthesis in Cephalosporium acremonium. D-amino acid oxidase.


The protocol and results of training nonradiologists to scan mammograms.


Migration of transplanted hematopoietic stem cells to the spleen of irradiated mice.


Graft-versus-host reactions in mice. I. Kinetic and immunogenetic studies of alloantigen-sensitive units of lymphoid tissue.


Bone marrow transplantation in patients with leukemia. Incidence and severity of graft-versus-host disease in successful HL-A-matched transplants.


The physician's assistant in Arizona.

The physician's assistant in Arizona.


Analysis of anesthetic-related morbidity in human recipients of renal homografts.


Pharmacological mechanisms in the eustachian tube.


Computerized evaluation of psychic effects of ketamine.


Microbiology of the middle ear and nasopharynx.


Abnormalities of left ventricular contraction induced by beta adrenergic blockade.


The polarity of stenothele differentiation in Hydra attenuata Pall.


The dehydrogenation of 1-indanol by a soluble oxidoreductase from bovine liver.


The effect of bea-adrenergic blockade on the cardiopulmonary response to ketamine.


Studies of nuclear acidic proteins. Evidence for their phosphorylation, tissue specificity, selective binding to deoxyribonucleic acid, and stimulation effects on transcription.


Dihydrouracil dehydrogenase of rat liver. Separation of hydrogenase and dehydrogenase activities.


The enzymic synthesis of ethanolamine plasmalogens.


Influences of hypercapnia on cardiac function in the newborn lamb.


Response of several hepatic adaptive enzymes to a shift from low to high protein diet in intact and adrenalectomized rats.


Failure of propranolol to antagonize halothane depression of the uterus.


Influence of embryo age on the expression of the GvH reaction in the chicken embryo.


Physician assistant--"a health care commando".


The vascular actions of clonidine in man.


Computerized management of the outpatient diabetic.


Antiarrhythmic effectiveness of alprenolol, a new beta adrenergic receptor blocking agent.


Some recent advances in anaesthesia of interest to ophthalmic surgeons.


Thymus-influenced immunological maturation of embryonic liver cells.


The sources of immunogenic stimulation of lymphoid cells mediating a local graft-versus-host reaction in rat kidney.


Necrotizing angiitis associated with drug abuse.


Decline of the necropsy.

Decline of the necropsy.


Radiological training and staffing in the Birmingham region and elsewhere.


Comparison of molindone and placebo in anxious depressed patients.


The occurrence of some amino acids in, and their release from, isolated supra oral sphincter preparations of the sea anemone Actinia equina.


Plasma corticosterone changes following alterations in brain norepinephrine and serotonin.


Care of the feet.

Care of the feet.


Medical versus operative treatment.

Medical versus operative treatment.


Testicular lipids. IV. Effect of unilateral and bilateral cryptorchidism on the fatty acids of esterified cholesterol in the rat and rabbit.


Insect bites and stings.

Insect bites and stings.


Role of transmitter uptake mechanisms in synaptic neurotransmission.


6-phosphogluconate dehydrogenase from sheep liver: inhibition of the catalytic activity by fructose-1,6-diphosphate.


Effect of adrenalectomy, corticosteroids and some other anti-inflammatory agents, Salazopyrin, thyroxine and vitamin A on the exchangeable sulphate pool and on sulphate incorporation in vivo into costal cartilage of the mouse.


The occurrence of multiple glyceraldehyde-3-phosphate dehydrogenases in cariogenic streptococci.


Steroids influencing the toxicity of L-tyrosine.


Proceedings of the 34th annual meeting of the Japanese Circulation Society. 3. March 28, 1970 Nogyo-kaikan and Kenmin-kaikan, Kobe.


Production of D-kynurenine and other metabolites from D-tryptophan by the intact rabbit and by rabbit tissue.


Atropine-resistant spasm of the dog colon induced by intermittent pelvic nerve stimulation.


Specificity of allogeneic cell recognition by human lymphocytes in vitro. Human lymphocytes proliferate in vitro in response to foreign histocompatibility antigens that are present on allogeneic lymphocytes. Within a population of immunocompetent lymphocytes there are specific subpopulations that respond to allogeneic cells from different individuals. A means of selectively eliminating such subpopulations is suggested.


A search for macrophages derived from rat thoracic duct lymphocytes during xenogeneic graft-versus-host reaction.


The hazard of short-term psychotherapy without assessment: a case history.


Moratorium or more.

Moratorium or more.


Small vessel arterial aneurysms of the kidney.


A cytochrome P-450-piperonyl butoxide spectrum similar to that produced by ethyl isocyanide.


The rejection crises in human renal transplantation.


The enhanced myocardial contractility of thyrotoxicosis. Role of the beta adrenergic receptor.


Myocardial infarction: recent accomplishments, current questions.


Effects of beta blockade on the peripheral manifestations of thyrotoxicosis.


Steroid hydroxylation in bovine adrenocortical mitochondria. Competition between side-chain cleavage of cholesterol and 11 beta hydroxylation.


Effect of tyramine on human umbilical artery in vitro. Fifteen of twenty-one perfused human umbilical artery preparations constricted in response to tyramine. These responses were unaffected by atropine, mepyramine or bromolysergic acid diethylamide but were blocked by phentolamine or dihydroergotamine. Cocaine augmented the constriction responses to tyramine or noradrenaline but not those to adrenaline, acetylcholine or 5-hydroxytryptamine. Infusion of noradrenaline restored the responses of preparations which had become tachyphylactic to tyramine.


Specificity of some ganglion stimulants. 1. The specificity of several ganglion stimulants has been tested on the isolated guinea-pig ileum by measuring the dose ratios produced by concentrations of hexamethonium.2. Most ganglion stimulants are also active at postganglionic receptors, some as blocking agents (for example, lobeline and dimethylphenylpiperazinium), others as agonists (for example, o-aminophenethyltrimethylammonium and, to a lesser extent, nicotine). The most specific ganglion stimulant, with the least activity at postganglionic receptors, was p-aminophenethyltrimethylammonium.3. The affinity constants of lobeline and dimethylphenylpiperazinium for the muscarine sensitive receptors in the guinea-pig ileum are 1.05 x 10(6) and 3.71 x 10(4), respectively.4. The antagonism of p-aminophenethyltrimethylammonium by hexamethonium gave results consistent with competition up to dose ratios of about 20. Such results could also be obtained if the antagonism were non-competitive, however, provided large responses could be obtained with less than about 5% of the receptors in the ganglia activated. The affinity constant of hexamethonium is about 2.6 x 10(5).5. It is suggested that the affinity of hexamethonium can largely be ascribed to hydrophobic bonding.


Beta-adrenergic blocking drugs.

Beta-adrenergic blocking drugs.


Effect of benzetimide (R 4929) on ruminal and intestinal motility in sheep.


Cardiovascular reactivity in the experimental hypertensive rat. 1. In pithed preparations, deoxycorticosterone (DOCA)/NaCl-induced hypertensive rats showed increased cardiovascular reactivity to injected noradrenaline, DMPP, tyramine, angiotensin and to sympathetic nerve stimulation.2. Pithed, chronic renal hypertensive rats showed similar hyperreactivity to noradrenaline, DMPP and tyramine but responses to sympathetic nerve stimulation were within normal limits.3. In the isolated, Krebs perfused mesentery preparation, vessels obtained from both DOCA/NaCl and renal hypertensive rats showed hyperreactivity to injected noradrenaline. Responses to periarterial nerve stimulation were also markedly increased in preparations from DOCA/NaCl hypertensive rats, while preparations from renal hypertensive rats showed this effect only at higher rates of stimulation (12 and 25 Hz).


Physician's assistant--second level entrepreneur?


The displacement of L-tryptophan and dipeptides from bovine albumin in vitro and from human plasma in vivo by antirheumatic drugs.


Salicylate-induced inhibition of collagen and mucopolysaccharide biosynthesis by a chick embryo cell-free system.


Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.


DL-5-hydroxytryptophan-induced changes in central monoamine neurons after peripheral decarboxylase inhibition.


Analysis of the action of m-tyrosine on blood pressure in the conscious rat: evidence for a central hypotensive effect.


The influence of hexobarbitone on calcium ion movements in isolated heart muscle.


Spasmolytic action of adenosine on the guinea-pig ileum.


The effect of the histidine decarboxylase inhibitor brocresine (NSD-1055) on gastric acid secretion in rats.


The influence of test conditions on the disintegration time of gelatin capsules.


Constituents of two varieties of Indian dill.


Application of orthogonal functions to spectrophotometric analysis of weakly absorbing compounds in tablets.


The relation between clinical anti-inflammatory activity and the displacement of L-tryptophan and a dipeptide from human serum in vitro.


The effect of additives on the release of drug from hard gelatin capsules.


The release of prostaglandin from the oesophagus and the stomach of the frog (Rana temporaria).


Interactions between prostaglandin E1 and noradrenaline in anaesthetized rats.


Cannabis-induced vocalization in the rat.


Propranolol interferes with inhibitory behaviour in rats.


Biliary excretion of penicillins in the rat.


Influences of cholinergic mechanisms on the function and turnover of brain dopamine.


The effect of angiotensin I and II on hind-limb blood flow in sheep.


Pressor responses in sheep to angiotensin II, noradrenaline and tyramine.


Acetylcholine and "auto-inhibition".

Acetylcholine and "auto-inhibition".


Is 5-hydroxytryptamine involved in the mechanism of action of fenfluramine?


The spectrophotometric determination of ampicillin in body fluids.


Acute pyogenic meningitis in Cairo, Egypt 1961-1966.


Cellular immunity induced by rous sarcoma virus in Japanese quail. II. Effect of thymectomy and bursectomy on oncogenesis of rous sarcoma virus.


Sustained atrial fibrillation induced by carbachol, methacholine and bethanechol.


Effect of theophylline and 3',5'-cyclic adenosine monophosphate on the salivary amylase secretion from rabbit parotid gland.


Sulfhydryl deficiency in connective tissue disorders: correlation with disease activity and protein alterations.


Biochemistry and pathology of tryptoPHAN METABOLISM AND ITS REGULATION BY AMINO ACIDS, vitamin B 6 and steroid hormones.


Virus haemorrhagic fever.

Virus haemorrhagic fever.


Malaria as a medical and veterinary zoonosis.


Activity of 6-phosphogluconate dehydrogenase in the preimplantation mouse and rabbit embryo.


Recent advances in immunology of cancer (a review).


Characteristics of the fluorescence spectra of apoenzyme and flavin portions of D-amino acid oxidase.


Nucleotides and nucleotide sugars in human blood cells. II. Group "O".


Water-soluble phosphates in horse granulocytes and lymphocytes.


Agroclavine hydroxylase of Claviceps purpurea.


The significance of the carbohydrate constituents of bovine thrombin for the clotting activity.


Observations on the increasing malignancy of tumours on prolonged growth: the influence of immunological changes in the host. Spontaneously occurring A-strain mouse mammary carcinomata were individually passaged, at equal intervals into separate groups of isogenic hosts. The tumours showed evidence of increasing autonomy as judged either by the decreasing host lymphoid hyperplasia they evoked, or their decreased killing time, as passaging continued. However, in general, no reduction was found in the ability of spleen cells from hosts bearing succeeding passages of the same tumour to induce a graft-versus-host reaction in (A × CBA)F(1) hybrid mice. It is therefore suggested that the increasing malignancy of the tumours studied was associated with a change in the tumour rather than increasing immunodepression in successive hosts.


Cytoplasmic changes during thioacetamide induced hepatocarcinogenesis in rats. Cytoplasmic changes were investigated in livers of rats at various intervals up to 50 weeks during primary induction of hepatoma by thioacetamide feeding.Microsomal Glucose-6-phosphatase and ATPase activities were shown to decrease progressively with increased period of thioacetamide feeding the fall in activities being more pronounced during the first 15 weeks.Hormonal induction of tryptophan pyrrolase and tyrosine transaminase activities was shown to undergo a significant decrease of 65% and 55% respectively at the end of 50 weeks feeding.The substrate induced tryptophan pyrrolase activity was decreased to 50% during the 50 weeks period whereas the substrate induced tyrosine transaminase activity gradually increased to 200%. The latter is attributable to differences in the optimal induction dose of tyrosine in normal and carcinogen fed rats.The m-RNA template lifetime for tryptophan pyrrolase was shown to be exceeding 24 hours in normal rats as against that of 13 hours in rats fed with carcinogen for 30 weeks. On the other hand the m-RNA template lifetime for tyrosine transaminase was 3 hours in control rats while it was 7 hours in the carcinogen fed rats.The observed changes were shown to occur long before the onset of malignant transformation.The alterations in terms of decreased Glucose-6-phosphatase and substrate induced tryptophan pyrrolase activities were shown to be reversible when the carcinogen was withdrawn from the diet after 30 weeks of feeding.The significance of these observations is discussed in relation to damage to endoplasmic reticulum during hepatocarcinogenesis.


Mixed-function oxidation in tumors.

Mixed-function oxidation in tumors. Liver microsomes of the rat contain a group of hydroxylating enzymes which are coupled to a greater or lesser degree to the electron flow system. In our studies, enzymes believed to be directly associated with the electron flow chain of NADPH, ferricyanide reduction, cytochrome c, cytochrome P-450 and substrate hydroxylation have been observed in livers obtained from normal, tumor-bearing and whole body irradiated rats as well as in Morris hepatoma 7777 and dimethyl-amino-biphenyl induced breast tumors.A significant difference appeared to exist in the activity of NADPH oxidase, NADP-ferricyanide reductase and benzopyrene hydroxylase when normal liver was compared with the liver obtained from a breast-tumor-bearing animal. Both cytochrome P-450 and cytochrome b(5) were decreased in the tumor-bearing animal.Tissue distribution of benzopyrene hydroxylase in normal, lactating and tumor-bearing Wistar rats has been studied.With the exception of NADPH oxidase, the activities of NADP-cytochrome c reductase, NADPH-ferricyanide reductase, benzopyrene hydroxylase and P-450 were markedly different in liver from Morris hepatoma 7777-bearing Buffalo rat when this was compared with homologous tissue obtained from normal Buffalo rat.Whole-body irradiated animals showed increased P-450 and NADPH oxidase activity in liver as a function of irradiation and there further appeared to be a correlation with decreased ferricyanide reductase activity.


Glucose intolerance in man during prolonged exposure to a hypobaric-hyperoxic environment.


Microbial formation of 17-alpha-C21 steroids. Stereochemistry of saturation of the delta-16-double bond.


The nurse-midwife in clinical practice.

The nurse-midwife in clinical practice.


Simulation of the Krebs cycle and closely related metabolism in perfused rat liver. I. Construction of a model.


Emulsion stabilization by non-ionic surfactants: experiment and theory.


Linking health and care. Further report and comment on RSH Congress.


Unjustified malpractice fears are preventing use of docotor's assistants.


Doxapram hydrochloride in hemorrhagic hypotension.


Adrenal 5 alpha-reductase activity in the rat: effects of gonadectomy: some cofactor and substrate requirements.


Failure of beta-adrenergic blocking agents to antagonize the hyperglycemic effect of epinephrine in mice.


The short-term effects of adrenergic-blocking agents in a small group of psychotic patients. Preliminary clinical observations.


Genetic and biochemical studies of the hexose monophosphate shunt in Neurospora crassa. II. Characterization of biochemical defects of the morphological mutants colonial 2 and colonial 3.


Genetic and biochemical studies of the hexose monophosphate shunt in Neurospora crassa. I. The influence of genetic defects in the pathway on colonial morphology.


Chemical radiation protection and the c AMP mechanism.


Primary medical care in Africa. M.D., or M.A.?


Ganglion-blocking effect of some alkaloids of the plant Verbascum nobile vel.


Modern views on pharmacology. VI. Peripheral cholinergic systems.


Group hysteria and the MMPI.

Group hysteria and the MMPI.


Relationship between professed values and emotional adjustment of college students.


Psychopathy, repression-sensitization, and anxiety.


Two-point MMPI code types and academic achievement.


Action of autonomic effector agents on the catecholamine secretion of the suprarenal medulla of the crow and the fowl.


Effect of sympathomimetic drugs upon the human oviduct in vivo.


Pressor reflexes produced by stimulation of afferent fibers in the cardiac sympathetic nerves of the cat.


Effects of prostaglandin A on the systemic and coronary circulations in the conscious dog.


The activation of striated muscle and its mechanical response.


Studies on the intestinal relaxation produced by dopamine.


Science and antiscience.

Science and antiscience.


Mechanism of reflexion in silvery layers of fish and cephalopods.


The effects of stationary retinal patterns upon the behaviour of neurons in the cat's visual cortex.


On the molecular mechanism of facilitated oxygen diffusion by haemoglobin and myoglobin.


Prediction of rehabilitation outcome in chronic court-case alcoholics.


Prison adjustment of alcoholic felons.

Prison adjustment of alcoholic felons.


Autoimmunization mechanisms in parainfectious encephalitis. I. Evidence of organ antibodies.


Uncoupling of monooxygenation and electron transport by fluorocarbons in liver microsomes.


The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7-alpha-Hydroxylase enzyme system.


Enzyme and coenzyme levels, oxygen uptake and lactate production in synchronized cultures of Chinese hamster cells.


Sympathetic modulation of immune response.


Altered lipid and serine metabolism in graft-versus-host disease.


Women's prisons--available population for dental research.


Kalemotropic effect of epinephrine: analysis with adrenergic agonists and antagonists.


Adrenergic mechanisms in canine mesenteric circulation.


Comparative N-demethylation of antihistaminic agents possessing dimethylaminoalkyl group by liver preparations from four animal species.


Tremorgenic toxins from penicillia. II. A new tremorgenic toxin, tremortin B, from Penicillium palitans.


The role of radiographs in clinical studies of caries-inhibitory agents.


Physiological implications of carnosine on the inflammation with reference to its inhibitory action of allergy and the vital defense mechanism.


Fluorides in community programs: results after four years of study of various agents topically applied by two technics.


The effect of self-applied fluoride paste.


Psychological assessment of therapy in coronary artery disease.


The physician assistant. A question in flux.


For a more efficient office.

For a more efficient office.


The certified medical assistant (CMA).

The certified medical assistant (CMA).


President's message.

President's message.


Pharmacological properties of a new beta-receptor blocking agent.


Studies on the site of action of o,p'-DDD in the dog adrenal cortex. II. TPNH- and corticosteroid precursor-stimulation of o,p'-DDD inhibited steroidogenesis.


Role of Ca++ in metabolic actions of drugs in intestinal smooth muscle.


Metabolic disposition of emepronium in animals and man with a note on the relationship between plasma concentration and effect.


Terminal oxidations in Bacillus brevis. II. The electron transport system of Bacillus brevis.


Circumstances influencing Otto Loewi's discovery of chemical transmission in the nervous system.


California group virus infections in small, forest-dwelling mammals of Wisconsin. Some ecological considerations.


Microbodies of Morris hepatomas.

Microbodies of Morris hepatomas.


Metabolism of cyclophosphamide by rat hepatic microsomes.


Survey of some enzyme patterns in transplantable Reuber mouse hepatomas.


Hemodynamic response to exercise after beta-adrenergic blockade in normal and labile hypertensive patients.


The development of the interstitial tissue of the human testis.


Polyarteritis as a cause of intestinal hemorrhage.


Influence of adrenergic blocking drugs on central angiotensin effects.


Hopelessness as a predictor of cervical cancer.


Common drugs can cause psychiatric illness.


Inhibition by adrenergic blockers of hemorrhagic necrosis in the rat's heart.


Morphological peculiarities of virions in clones and population of Venezuelan equine encephalomyelitis virus.


Effects of phenylalanine analogues on virus multiplication and protein synthesis in a cell-free system.


Homologous interference by Newcastle disease virus. First stages of interaction of challenge virus with pre-infected cells.


Physiology of interferonogenesis. II. Mechanism of action of alanine and serine on interferon production in chick embryo fibroblast cultures.


Antibody against Hong Kong influenza viruses in pigs.


Experimental infection of pigs with Hong Kong influenza viruses.


Plaquing of different strains of Tahyna virus in GMK cells.


Oral infection of young mice with herpes simplex virus.


Effect of heparin on reproduction of, and interferon production and interference by, Newcastle disease virus in chick embryo cell cultures.


Haemagglutination reaction with avian myeloblastosis virus.


Structural changes observed in human blood after viral vaccination.


Neutralizing antibody formation in newborn colostrum-deprived germfree piglets after peroral administration of attenuated pseudorabies virus.


Physico-chemical and antigenic properties of some nonspecific inhibitory substances of arbovirus haemagglutination.


Anatolii Aleksandrovich Smorodintsev--70th anniversary.


Trends in the development of antithrombotic agents.


Comparison of the arrhythmic doses of epinephrine during Forane, halothane, and fluroxene anesthesia in dogs.


Gibson spiral maze and MPI scores: a comparison using normal adolescent subjects.


Current status of regional analgesia for diagnosis and therapy.


Ulcerative colitis in children under one year: a twenty-year review.


A function for alpha-tocopherol: stabilization of the microsomal membrane from radical attack during TPNH-dependent oxidations.


Psychopathology and perception of physiques.


Antagonism of intracerebrally induced nicotinic convulsions in mice: a method for measuring the central antinicotinic activity of CNS acting agents.


Further aspects of the exploratory behaviour in aggressive mice.


Fatal pneumococcemia and sickle cell anemia.


Graft-versus-host reactions mediated by spleen cells from amyloidotic and nonamyloidotic mice.


The capacity of lymphocytes from rats bearing enhanced kidney allografts to mount graft-versus-host reactions.


A pharmacologic evaluation of the adrenergic receptors of the rabbit detrusor muscle.


Studies of the 3,methoxy-derivatives of isoprenaline, isoetharine and WG 253 on isolated human tissue.


New aspect of guinea pig liver 17-beta-hydroxysteroid (testosterone) dehydrogenase.


Hypermagnesemia following exposure to acute stress.


Is phentolamine an alpha-adrenergic blocker?


Effect of temperature on the relationship between hepatic microsomal cytochrome P-450 reduction and ethylmorphine demethylation.


Cardiovascular effects of prinodolol (LB-46), a potent beta-adrenergic receptor antagonist.


Nonspecific cytotoxicity in graft-versus-host reactions.


Graft-vs-host reaction in a xenogeneic combination: mechanism of the reaction.


Reduction of portal hypertension by ganglionic blockade.


A noncholinergic excitatory nerve pathway in guinea pig colon.


Oxygen dissociation characteristics of the blood of the rainbow trout, Salmo gairdneri.


A clinical study with propericiazine in chronic psychotic patients.


Alcoholic treatment: the group experience.


Adaptive changes of glycerol 3-phosphate dehydrogenase level in rat skin: effects of starvation, alloxan diabetes and insulin.


Some aspects of the control of dehydroepiandrosterone synthesis in the human adrenal gland in vitro.


The rate-determining step in the oxidative decarboxylation of isocitric acid.


Interconvertible microheterogeneity of glucose-6-phosphate dehydrogenase in rat liver.


Effect of nigral lesion on chlorpromazine-induced acceleration of dopamine synthesis from [14C]tyrosine.


Effects of K+ on the catalytic and regulatory properties of homoserine dehydrogenase of Pseudomonas fluorescens.


Energy metabolism of the normal and cryptorchid rat testis.


Studies on a matrix-bound three-enzyme system.


P.N.A.-threat or boon to pediatricians?

P.N.A.-threat or boon to pediatricians?


The nurse-P.A.: one experiment that's working.


Field evaluation of diethyltoluamide (deet) as a mosquito repellent.


Cardiovascular effects of intravenous lignocaine during nitrous oxide-halothane anaesthesia.


Activators and inhibitors of lens aldose reductase.


The acute cardiovascular changes and adrenergic blockade by droperidol in man.


The nonvalue of sputum culture in the diagnosis of pneumococcal pneumonia.


Stereochemistry of the hydroxylation in 4-hydroxysphinganine formation and the steric course of hydrogen elimination in sphing-4-enine biosynthesis.


Predictor patterns in the management of therapy-resistant schizophrenia.


Correlative neuroanatomical and neuropharmacological study of tremor and catatonia in the monkey.


The effect of parathyroid extract and dibutyryl cyclic AMP on NAD and NADP levels in embryonic mouse calvarium explants.


The potential use of xylitol in glucose-6-phosphate dehydrogenase deficiency anemia. NADP-linked xylitol dehydrogenase has been found to be present in human red blood cells. This enzyme activity is normal in most glucose-6-phosphate dehydrogenase (G6PD)-deficient red cells. Xylitol was explored as a potential agent for treatment of hemolysis in patients with G6PD-deficiency. Intracellular GSH (glutathione, reduced) was first converted to its oxidized form by incubation of the erythrocytes with acetylphenylhydrazine or by pretreatment with methyl phenyldiazenecarboxylate. The addition of 0.15 M xylitol was shown to be more effective than 0.15 M glucose in maintaining the levels of GSH in G6PD-deficient red cells during such oxidative challenge. Rabbit erythrocytes contain less activity of G6PD and glutathione reductase compared with the normal human adult values, but have an active xylitol dehydrogenase. The rabbit erythrocyte is sensitive to acetylphenylhydrazine and primaquine phosphate. In both in vivo and in vitro experiments, xylitol was found to partially prevent acetylphenylhydrazine induced acute hemolysis of the rabbit red cell and GSH content was found to be preserved. The intravenous injection of xylitol (0.5 g/kg body weight per 6 hr) for 6 days, seemed to be nontoxic to the animal. The results suggest that xylitol should be further investigated as an agent for the treatment of G6PD-deficient patients during acute hemolytic episodes.


Treatment of testicular tumors.

Treatment of testicular tumors.


Canadian Veterinary Students Association student editorial. Does your practice employ a student?


Catecholamine antagonism to oxytocin-induced milk-ejection.


Mosquito-borne infections in Fiji. II. Arthropod-borne virus infections. Surveys of arbovirus activity in Fiji were conducted over a 10-year period from December 1959 to December 1969. No arboviruses were isolated from over 200,000 mosquitoes, 9000 ticks, or 575 serum samples. Eight thousand human and 1117 bird, bat and animal sera were tested for haemagglutination-inhibiting arbovirus antibody using a variety of group A, group B and Bunyamwera group antigens. Only a small number of low-titre reactions were found among the non-human sera, but 14% of all human sera were found to contain Group B antibody. The antibody prevalence increased with increasing age, from less than 1% for persons born since 1950, to 70% for persons born before 1900. The age differences in prevalence could be used to estimate the time and size of previous epidemics. Differences were found in antibody prevalence between the sexes, between ethnic groups and between persons from different regions. These differences could be explained in terms of climate, location and custom.Historical and serological evidence both suggest that all the antibody detected was due to past exposure to dengue virus. The very high proportion of the population with no dengue antibody makes Fiji a high-risk area for a further dengue epidemic. Dengue virus is known to be active in the Pacific and South-East Asia.


Mosquito-borne infections in Fiji. 3. Filariasis in northern Fiji: epidemiological evidence regarding the mechanisms of pathogenesis. During a filariasis survey conducted in northern Fiji in 1968-9 examinations were made for microfilaraemia, enlarged lymph nodes and elephantiasis. Analysis of the microfilarial densities at different ages and the number of anatomical sites showing lymph gland enlargement or elephantiasis have been used to provide evidence on the clustering of infections and pathogenesis.Although there is no evidence of clustering of risk of infection, there is evidence favouring the clustering of adult filariae in individuals. Nevertheless the number of sites of lymph node enlargement do not correspond with this finding and statistical evidence suggests that lymph-node enlargement is not necessarily associated with the near presence in the body of adult filariae, whether dead or alive.Males of Indian ethnic origin showed a higher prevalence of elephantiasis than males of Fijian ethnic origin, but women of either ethnic race showed prevalences lower than those of men.The onset of elephantiasis at a site does not directly reflect the number of infections sustained in the local area, but it appears that filariasis first induces for a limited period a proneness to elephantiasis. During this period a random and discrete event may induce the onset of elephantiasis. The nature of the event is unknown, but it probably is not trauma.


Polyarteritis nodosa: ureteral involvement.


Mosquito-borne infections in Fiji. I. Filariasis in northern Fiji: epidemiological evidence regarding factors influencing the prevalence of microfilaraemia of Wuchereria bancrofti infections. A survey of microfilaraemia among the population of Vanua Levu, Taveuni and Koro islands in northern Fiji was conducted in 1968 and 1969 as a prelude to a campaign of mass treatment with diethylcarbamazine.The prevalences of microfilaraemia were found in the more moist conditions of Taveuni and Koro and on the windward southern side of Vanua Levu to be higher than on the drier northern side of Vanua Levu. On both sides of Vanua Levu prevalences were lower inland than near the coast.Under apparently similar environmental conditions those of Fijian ethnic origin exhibited a higher prevalence of microfilaraemia than that shown by Indians. This ethnic difference and a difference between the prevalences in male and female Fijians are considered to be due more to higher rates of recovery from microfilaraemia in Indians and Fijian women than to diminished exposure to mosquitoes. Mathematical models have been used as an aid to the interpretation of the data, and, where appropriate, comparison has been made with the prevalence of antibodies to dengue, an arbovirus having the same vectors.Household infections were analysed by computer techniques. Infections in large households were not proportionately higher than in small households, indicating that transmission was not intrafamilial. The clustering of infections within households, though present, was not marked. Among the occupants of outlying settlements the prevalence of microfilaraemia was relatively low indicating a lower risk of infection due to isolation.


Some behavioral effects of ascorbic acid deficiency.


A syndrome of dwarfism, mental retardation, lens opacities, nystagmus, strabismus, cryptorchidism and absent patellae. Report of 2 cases in siblings.


Graft-versus-host disease. Morphologic variation and differential diagnosis in 8 cases of HL-A matched bone marrow transplantation.


The supply of electrons for ovarian cholesterol side-chain cleavage.


The amino acid oxidases of Plasmodium berghei.


Rabies: quarantine upheld.

Rabies: quarantine upheld.


Biphasic mechanical response of the isolated vas deferens to nerve stimulation.


Hypothermia produced in mice by histamine acting on the central nervous system. 1. In mice 1-10 mug histamine injected intraventricularly produces hypothermia.2. This hypothermia was not antagonized by chlorcyclizine administered subcutaneously or intraventricularly, but chlorcyclizine injected intraventricularly was effective in antagonizing the hypothermia produced by a subcutaneous injection of histamine.3. Pretreatment with atropine was without effect on the hypothermia produced by an intraventricular injection of 10 mug histamine.4. Amphetamine and tranylcypromine not only effectively reduced the intensity of, or abolished, the hypothermia but also reversed the response to an intraventricular injection of 10 mug histamine so that hyperthermia was produced. Pargyline was without effect.5. Tolazoline strongly potentiated the hypothermia produced by the intraventricular injection of 10 mug histamine, but phentolamine did not.6. It is concluded that at least part of the hypothermia produced by a subcutaneous injection of histamine arises as a result of an action on the central nervous system.7. The possible mechanisms by which histamine acting on the central nervous system produces hypothermia and the suggestion that histamine may have a physiological role in thermoregulation are discussed in the light of these findings.


Cardiovascular pharmacology of quazodine (MJ-1988), with particular reference to effects of myocardial blood flow and metabolic heat production. 1. The effects of intravenous infusions of quazodine (6,7-dimethoxy-4-ethylquinazoline; MJ-1988) on myocardial blood flow, myocardial metabolic heat production and on general haemodynamics have been studied in cats anaesthetized with sodium pentobarbitone.2. Quazodine (0.25 and 0.5 (mg/kg)/min for 10 min) decreased diastolic blood pressure, peripheral vascular resistance, systolic ejection time and left ventricular end-diastolic pressure. Heart rate, cardiac effort, output and external work and left ventricular dP/dt were markedly increased. These changes are indicative of increased myocardial contractility and peripheral vasodilatation.3. In a dose of (1.0 mg/kg)/min, quazodine had a more marked hypotensive effect, systolic pressure being significantly reduced, and had less effect on left ventricular dP/dt and cardiac effort. Calculated external cardiac work was slightly reduced and there were very occasional nodal arrhythmias.4. Changes in heart rate, aortic dP/dt and diastolic blood pressure induced by quazodine were unaffected by the previous administration of the beta-adrenoceptor blocking agent alprenolol in a dose (1.0 mg/kg) which abolished the effects of isoprenaline.5. In all doses, quazodine markedly increased local blood flow (by 70-540%) around an implanted myocardial heated thermocouple recorder. ;Corrected temperature', an index of local myocardial metabolic heat production, was almost unchanged and it is suggested that increased myocardial contractility, occurring with unchanged metabolic heat production and oxygen consumption, probably results from a concomitant decrease in intramural wall tension.


The relation between the vapour pressure of a drug and its concentration emerging in the air stream from a nasal inhaler.


Interaction of preservatives with cetomacrogol.


The effect of drugs upon the uptake of 5-hydroxytryptamine and metaraminol by human platelets.


The drug release characteristics of various rectal suppositories as determined by specific ion electrodes.


The effect of brocresine (NSD-1055) on the histidine decarboxylase activity in the rat gastric mucosa.


Effects of papaverine and eupaverin on calcium uptake by isolated sarcoplasmic vesicles.


Species-dependent effects of fenfluramine on the central nervous system.


The estimation of the "free" and "bound" acetylcholine content of rat brain.


Anti-acetylcholinesterase activity of some stereoisomeric aminobornanes.


Aspirin dissolution: polymorphism, crystal habit or crystal defects.


The site of the inhibitory action of salicylate on protein biosynthesis in vitro.


Interpretation of dissolution rate maxima: dependence upon tablet compression force.


Inhibition of 5-hydroxyindoleacetic acid transport from the spinal fluid by probenecid.


Amphetamine toxicity in genetically aggressive and non-aggressive mice.


Some effects of butoxamine on glycolysis in the mouse brain.


The effect of angiotensin II on the release of catecholamines in the sheep.


The effect of angiotensin I on renal blood flow in sheep.


5-Hydroxytryptamine and monoamine oxidase in adult and foetal sheep blood vessels.


Potentiation by desipramine of the pressor and depressor effects of dopamine.


A novel thin-layer chromatography system for lysergide (LSD).


The tetrahydrocannabinol content of cannabis leaf.


Isolation of speciogynine from the leaves of Mitragyna inermis (Willd.), O. Kuntze.


'Metabolism' of 'amphetamines' to oximes as a route to deamination.


Distruption by carcinogens of the hormone dependent association of membranes with polysomes.


MMPI correlates with disability in multiple sclerosis.


Educational and diagnostic MMPI characteristics of a private hospital population.


Multidimensional scaling used to evaluate students residing in a rehabilitation unit.


Correlates of delinquent behavior.

Correlates of delinquent behavior.


MMPI and EPPS profiles of high and low verbal interactors in therapy groups.


Studies on the mechanism of tryptophan induction of certain hepatic enzymes.


Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase.


Studies of tryptophan metabolism in experimental animals and man during infectious illness.


Periarteritis nodosa. A remission achieved with combined prednisone and azathioprine therapy.


Functions of the doctor.

Functions of the doctor.


Effects of amino acid derivatives and drugs on the metabolism of tryptophan.


Progressive systemic sclerosis terminating as periarteritis nodosa.


G6PD deficiency and chronic hemolysis: four new mutants--relationships between clinical syndrome and enzyme kinetics.


Sulthiame overdosage.

Sulthiame overdosage.


Stimulating effect of C-reactive protein on phagocytosis of various species of pathogenic bacteria.


Dehydrated food for research studies in simulator chambers.


Effective use of isoniazid and an antihistamine in clinical renal transplantation.


An experimental study of thrombotic ulceration of the gastrointestinal mucosa.


Neurohumoral transmitter studies of canine autonomic innervation.


Beta-mediated vasoconstrictor and vasodilator responses in the canine mesenteric and hepatic circulation.


Immune paralysis induced by pneumococcal polysaccharide. I. Peritoneal cell phagocytic activity and interaction with spleen cells.


Immune paralysis induced by pneumococcal polysaccharide. II. Studies with peritoneal and spleen cell extracts and RNA.


Effect of thyroid hormones on epinephrine-induced lipolysis in adipose tissue of rats.


Beta-adrenergic blocking agents. 10. (3-amino-2-hydroxypropoxy)anilides.


Quinuclidine analogs of tobacco alkaloids.


Development of plasma cells during acute graft-versus-host reactions.


Extraction procedures and their influence on the values of nicotinamide-adenine dinucleotides in frozen brain tissue.


Immunodiffusion studies on pneumococcal antigens with special reference to serotype 27.


Exercise tolerance in patients with angina pectoris. Daily variation and effects of erythrityl tetranitrate, propranolol and alprenolol.


Increased dihydrofolate reductase synthesis in Diplococcus pneumoniae following translatable alteration of the structural gene. 3. Further evidence on the extent of genic involvement.


Evidence for increased constitutiveness of NADP-linked dehydrogenases in the starved-refed rat.


Phospholipase in the nematocyst toxin of Physalia physalis.


Comparison of tentacle extracts from Chiropsalmus quadrigatus and Chironex fleckeri.


Toxic material from the tentacles of the cubomedusan Chironex fleckeri.


A pathogen of the malaria parasite.

A pathogen of the malaria parasite.


Some immunological aspects of sea nettle toxins.


The hydrolysis of nicotinamide adenine dinucleotide phosphate by serum alkaline phosphatase.


Biochemistry of the bioluminescence of colonial hydroids and other coelenterates.


Energy transfer in a bioluminescent system.


Systems analysis of pediatrician efficiency.


An ultrastructural study of experimental demyelination and remyelination. IV. Recurrent episodes and peripheral nervous system plaque formation in experimental allergic encephalomyelitis.


The blood in arthritis.

The blood in arthritis.


Studies on the intestinal vasodilatation observed after mechanical stimulation of the mucosa of the gut.


Cardiovascular and contractile responses to nondepressant beta-adrenergic blockade.


Regulatory responses of cerebral vasculature after sympathetic denervation.


Alpha-adrenergic inhibition of immunoreactive insulin release during deep hypothermia.


The adrenergic receptors of the coronary circulation in the isolated dog heart.


Hemodynamic effects of alprenolol (H56-28).


Drug effects on the blood pressure response to postural changes in the unanesthetized rabbit.


Microbodies in experimentally altered cells. VI. Thyroxine displacement from plasma proteins and clofibrate effect.


The action of MJ1999 on the lethal effects of lanatoside C and ouabain in intact dogs.


Stimulant activity of pemoline and magnesium hydroxide.


Histochemical demonstration of 3 beta-, 3 alpha-, 11 beta-, and 17 beta-hydroxysteroid dehydrogenases in the testis of Fundulus heteroclitus.


A histochemical study of ovarian function in the ovoviviparous elasmobranch, Squalus acanthias.


Lymphocyte transfer factor.

Lymphocyte transfer factor.


Prevalence of dental caries in Australian aboriginal children resident in Carnarvon, Western Australia.


A study of caries aetiology in New South Wales schoolchildren. I. The streptococcal flora of plaque and caries prevalence.


Penicillin-resistaant pneumococci.

Penicillin-resistaant pneumococci.


Beyound the moon--some problems in space medicine.


Physicochemical characteristics of central neurotransmitters.


Effects of epinephrine, norepinephrine and isoproterenol against challenge in Bordetella pertussis-treated and beta-adrenergic blocked mice.


Fresh thoughts on a growing problem: how we could arrest proliferation of allied health professions.


Insulin secretion studied in the perfused rat pancreas. II. Effect of glucose, glucagon, 3'5' adenosine monophosphate, theophylline, imidazole and phenoxybenzamine; their interaction with diazoxide.


Medex: a regional experiment.

Medex: a regional experiment.


Experimental infection of horses with three strains of Venezuelan equine encephalomyelitis virus. I. Clinical and virological studies.


Experimental infection of horses with three strains of Venezuelan equine encephalomyelitis virus. II. Experimental vector studies.


Photokinetic micro assay based on dehydrogenase reactions and bacterial luciferase.


Induction of tyrosine aminotransferase by dibutyryl cyclic-AMP employing hepatoma cells in tissue culture.


Unipolar and bipolar primary affective disorder.


Antiarrhythmic effects of dichloroisoprenaline, H 56-28, ICI 50172, LB 46, MJ 1999 and propranolol on aconitine-induced atrial and ouabain-induced ventricular arrhythmias.


Legal aspects of public health nursing.

Legal aspects of public health nursing.


The 7th bi-ennial Conference of the Caribbean Nurses' Organization.


The redox state of nicotinamide nucleotides in human blood platelets.


Studies of highly purified tyrosine aminotransferase in rat brain.


Effects of droperidol on the vasoconstriction produced by noradrenaline, histamine, sympathetic nerve stimulation and potassium ions in the isolated rabbit auricular artery.


A new neural inhibitor in the gut.

A new neural inhibitor in the gut.


Dissecting aneurysm of superior mesenteric artery.


The view box.

The view box.


Vesicoureteral reflux.

Vesicoureteral reflux.


Clinical experience with a new laxative in children.


Disseminated chlamydial infection. Infection by intracellular parasites, Chlamydiae, has a great variance in clinical appearance and increasing frequency of appearance.


EKG of the month.

EKG of the month.


Drug therapy in alcoholism. It is especially important in the prevention of such complications as seizures, DT's, Wernicke's encephalopathy, or polyneuritis.


Medical gobbledygook and writer's gookledygobb.


The "communication gap" between you and your staff.


Style of adaptation to perceived aversive maternal stimulation and selective attention to evaluative cues.


Inflammatory pseudotumours of the orbit: a probable case of microfilarial granuloma of the orbit.


The drug treatment of hypertension.

The drug treatment of hypertension.


The guest editor speaks out.

The guest editor speaks out.


A look at emerging health manpower developments.


Bridging the medical care gap: the physician's assistant.


Let's look at the P.A. A new member of the health team.


Eastern "equine" encephalitis in Massachusetts.


The effect on human dental caries of weekly oral rinsing with a sodium fluoride mouthwash: a final report.


The influence of the neurohumor serotonin on hibernation in the golden-mantled ground squirrel, Citellus lateralis.


Speaking out on: the physician's assistant.


Effect of rubidium and caesium on electrogenic sodium pumping in rat myometrium.


A peripheral sensory basis for behavioral regulation.


Action of DDT on evoked and spontaneous activity from the rainbow trout lateral line nerve.


Relationship between membrane potential and spike configuration recorded by sucrose gap method in the ureter smooth muscle.


Effect of multivalent cations and drugs on Ca uptake by the rat myometrial microsomes.


Steroidogenesis in post- and pre-spawned ovaries of a cichlid fish, Tilapia aurea.


Nitrogen and water excretion of wallabies: differences between field and laboratory findings.


ATP-dependent Ca uptake by subcellular fractions of uterine smooth muscle.


Electrophysiological properties of nerve cell bodies in the sixth abdominal ganglion of the Maine lobster, Homarus americanus.


Metabolism of intraperitoneally injected  14 C-histamine in the yellow eel (Anguilla anguilla).


Amylase in tissues of the bullfrog, Rana catesbiana and the leopard frog, Rana pipiens.


Relationship between the activity of Na+-K+-activated adenosinetriphosphatase and the number of chloride cells in eel gills with special reference to sea-water adaptation.


Red cell 2,3-diphosphoglycerate in hibernating ground squirrels.


Caries experience of West Hartlepool children aged 2-18 years.


Non-electrolyte permeability across Bufo bufo gall-bladder.


Psychological adjustment and psychiatric complications following open heart surgery.


SAMA vote in the AMA?

SAMA vote in the AMA?


Maldescent of the testicle.

Maldescent of the testicle.


VEE vaccine: fortuitous spin-off from BW research.


A comparison of the effects of propranolol and practolol on forced expiratory volume and resting heart rate in normal subjects.


Dental caries experience and treatment patterns. Social differences in 1,252 university students.


Action of beta-adrenolytics on the isolated guinea-pig atria.


Double-blind three-dose trial of oral alprenolol in angina pectoris.


Surface mapping of the RS-T segment in acute myocardial infarction and effect of beta-blockade.


Acute effects of oral alprenolol on exercise tolerance in patients with angina pectoris. A dose-response study.


Beta-blockade in experimental myocardial ischaemia: metabolic and electrocardiographic effects.


Heart rate response to certain physiological manoeuvres: proposed measure of degree of  -receptor blockade.


Effects of propranolol, oxprenolol, and practolol on denervated dog heart.


Effect of cardioselective  -adrenergic blockade in patients with abnormal left ventricular function.


Assessment of  -adrenergic blocking and non-specific properties of propranolol.


Role of peripheral vascular system in control of cardiac output, demonstrated by use of selective  -adrenergic stimulating and blocking agents.


Research design and narcotic addiction proneness.


Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.


Attempts to detect an alternative vital role for the reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase structural gene in Aspergillus nidulans. A possible alternate vital role of the structural gene for reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase in Aspergillus nidulans was tested for and found to be absent in a significant number of haploid and diploid strains.


Transforming ability of bacterial deoxyribonucleic acid in relation to the marker efficiencies in Diplococcus pneumoniae during thymidine starvation. Thymidine starvation induces a decrease in transforming activity of pneumococcus deoxyribonucleic acid. The integration of low- and high-efficiency markers seems to be equally affected.