Effect of blockade of adrenergic alpha-receptors on the activity of preparations stimulating and inhibiting the contraction of the rat uterus.


Parental-F1 hybrid bone marrow chimeras: high incidence of donor-type lymphomas.


Reflections on the use of propranolol in angina pectoris.


Cholinoceptive sites in rat sympathetic ganglia.


Studies on heart anaphylaxis. 3. Effect of antigen and histamine on perfused guinea-pig heart.


The effects of some psychoactive drugs on rat brain adenosine triphosphate levels.


Inhibition of gastric emptying by endotoxin (bacterial lipopolysaccharide) in conscious rats and modification of this response by drugs affecting the autonomic nervous system.


Pharmacological properties of Su-19789B, a unique central nervous system stimulant.


Antibiotics and ureter: II. Dicloxacillin.


On a successfully treated acute oral paraoxone (E 600) poisoning.


Organization of the membranes of the endoplasmic reticulum.


Role of cytochrome p-450 in mixed function oxidases using the reconstituted steroid 11beta-hydroxylase of adrenal mitochondria as an example.


Microsomal lipid peroxidation.

Microsomal lipid peroxidation.


Oxygen interaction with reduced cytochrome P-450.


The role of pteridine cofactors in mixed function oxidases.


Some aspects on the hydroxylation of drugs, steroid hormones and fatty acids (omega-oxidation) in rat liver microsomes.


Sign and seer: another example.

Sign and seer: another example.


Antineoplastic components of marine animals.


Effect of chlorpromazine, mepyramine, prenylamine and reserpine of 5-hydroxytryptamine content and fine structure of rat peritoneal mast cells incubated in vitro.


Glutathione reductase from Rhodospirillum rubrum.


Studies on gluconate metabolism in Aspergillus niger. 3. Purification and properties of phosphogluconate dehydrogenase.


Investigations into yellow fever virus and other arboviruses in the northern regions of Kenya. Previous studies having shown an appreciable level of yellow fever immunity to exist in northern Kenya, further epidemiological and serological surveys were carried out there in 1968 in an attempt to define more clearly the distribution of yellow fever and to locate possible vector and reservoir hosts of the disease; these surveys also provided information on a number of other arboviruses.Altogether 436 sera from 5 areas in northern Kenya were screened by haemagglutination-inhibition tests with 8 antigens, and 107 of these sera by neutralization tests for Group-B arboviruses. Small numbers of yellow-fever-immune adults were found in Ileret, Garissa, Loglogo and Mikona. At Marsabit high proportions of immune adults and children were found among the Burgi tribe. As the Burgi are permanent agricultural workers on Marsabit Mountain, an entomological investigation was made, over 15 000 mosquitos being collected. From these, 13 strains of Pongola virus, 1 strain of Semliki Forest virus and an unidentified virus were isolated, but no yellow fever strains. Aedes africanus and Aedes simpsoni were not found at Marsabit; small numbers of Aedes aegypti were collected biting man. The vector potential of other mosquitos collected (particularly Mansonia africana, which is present throughout the year) is discussed.


Effects of hyperglycemia, tolbutamide and glucagon on the pathways of glucose oxidation in the goosefish islet in vitro.


The effects of hypoxia on choice reaction time and movement time.


The diagnosis of polyadenomatosis of endocrine glands.


Filariasis in Sabah, East Malaysia.

Filariasis in Sabah, East Malaysia.


Humoral and cellular responses of mice to a pneumococcal polysaccharide antigen. Circulating antibodies.


Humoral and cellular responses of mice to a pneumococcal polysaccharide antigen. Plaques and paralysis, in vivo and in vitro.


Ureteral obstruction.

Ureteral obstruction.


Popliteal aneurysm: an unresolved problem.


Failure of thymectomy in a six-year old child with myasthenia gravis.


Emerging developments in ophthalmology.

Emerging developments in ophthalmology.


Pulmonary function evaluation.

Pulmonary function evaluation.


Hypnotic effect of methaqualone employing placebo responder elimination.


Leprosy in Ceylon.

Leprosy in Ceylon.


Self-esteem, reception, and influenceability.


Recurrent ventricular tachyarrhythmias in a patient with a prolonged Q-T interval.


Current concepts in the management of the undescended testis.


Rectal pyrilamine-pentobarbital compared with promethazine for vomiting in children.


Bone marrow transplantation. Aggravating factors in graft-versus-host disease.


Urinary beta-glucuronidase in renal homotransplantation.


Treatment of canine graft-versus-host disease with methotrexate and cyclo-phosphamide following bone marrow transplantation from histoincompatible donors.


The mechanism of genetic recombination.

The mechanism of genetic recombination.


Arbovirus encephalitis surveillance in Iowa.


An evaluation of doxapram hydrochloride to control respiration in dogs during and after inhalation anesthesia.


Enzyme histochemical activity in small intestine of the germfree cat.


Liver peroxisomes, cytology and function.


The enzymatic characteristics of peroxisomes of amphibian and avian liver and kidney.


The function of the delayed sensitivity reaction as revealed in the graft reaction culture.


Glucose 6-phosphate dehydrogenase assay in liver and blood.


Cardio-selective beta-adrenergic inhibition by practolol in angina pectoris.


Sympathin E, sympathin I, and the intracellular level of cyclic AMP.


The First Canadian Dental Students Conference.


Effect of phentolamine, an alpha receptor blocking agent, on epinephrine, ADP and collagen induced factor 4 release and platelet aggregation.


Amino acid transport in hepatoma cell cultures during tyrosine aminotransferase induction. Alpha-aminoisobutyric acid transport in hepatoma cells in culture was increased by insulin but not by hydrocortisone. Both of these agents induce tyrosine aminotransferase activity in this system. The apparent increase in alpha-aminoisobutyric acid transport and tyrosine aminotransferase activity produced by glucagon is probably caused by insulin contamination. Insulin did not increase transport in this system until after tyrosine aminotransferase activity had reached maximum levels. The mechanisms underlying increased alpha-aminoisobutyric acid transport appear to differ from those for tyrosine aminotransferase induction with hydrocortisone despite their close association in previous whole animal experiments.


Clinical pharmacology of beta-receptor-blocking drugs.


Intravascular coagulation and arterial disease.


Adrenergic blockade as a research tool in clinical medicine.


The management of bronchial asthma in the aged.


Selecting appropriate mental health and psychiatric nursing content for associate degree nursing programs.


Hypotensive amines: Unbridged cyclohexane analogues of mecamylamine.


Associate degree nursing instruction in science: integration of subject matter.


Preparing the technical nurse practitioner.


Maternal and child nursing content for the associate degree nursing program.


Posttranscriptional control of tyrosine aminotransferase synthesis by insulin. Adrenal steroid hormones induce the synthesis of tyrosine amino-transferase (TAT) in HTC cells, an established line of rat hepatoma cells in tissue culture. The addition of insulin to cells previously induced in a serum-free medium results in a rapid two- to threefold further increase in the rate of synthesis of TAT and a small increase in total amino acid incorporation. These changes do not require concomitant RNA synthesis, suggesting that insulin acts at a step in protein synthesis beyond that of gene transcription. Although the effects of insulin on HTC cells are similar to those caused by dialyzed bovine serum, evidence is presented that insulin and serum affect different aspects of TAT synthesis. Unlike the glucocorticoids, insulin does not cause the accumulation of TAT mRNA, nor the sustained induction of TAT. The continued presence of the inducing steroid is required to permit maximal expression of the insulin effect.


Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine. The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine synthetase. In the present work, D-methionine-SR-sulfoximine, and highly purified preparations of L-methionine-S-sulfoximine and L-methionine-R-sulfoximine were tested in mice for convulsant activity; only L-methionine-S-sulfoximine produced convulsions. The finding that only one of the four optical isomers of methionine sulfoximine induces convulsions, and that only this same isomer inhibits glutamine synthetase, lends support to the conclusion that these two effects of methionine sulfoximine are closely connected.


Fatty acids and pronethalol-induced reversal of saline diuresis.


An interpretive summary of the Bermuda workshop.


Mansonia leberi, a new mosquito from the Panama Canal Zone, with notes on its biology (Diptera: Culicidae).


Exercise-induced glycogenolysis and lipolysis in the rat: hormonal influence.


Synthesis of a mucous cuticle by a zoanthid.


Hydroxylation of aliphatic compounds by liver microsomes. I. The distribution pattern of isomeric alcohols.


Optical rotatory dispersion of the two glucose-6-phosphate dehydrogenases from Candida utilis.


Purification and properties of dihydrouracil dehydrogenaase from pig liver.


Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.


Method for the detection of a biochemical riboflavin deficiency. Stimulation of NADPH2-dependent glutathione reductase from human erythrocytes by FAD in vitro. Investigations on the vitamin B2 status in healthly people and geriatric patients.


Diagnosis and treatment of pheochromocytoma.


Regulation of hepatic tyrosine transaminase in vivo through interaction of norepinephrine and the pyridoxal phosphate co-factor.


The pharmacology of barbiturates.

The pharmacology of barbiturates.


The effects of hypoxia and hypercarbia on myocardial catecholamines.


Mechanism of antitremorine-activity of adrenergic beta-receptor antagonists in the rat.


Clonal evolution in two patients with autoimmune disease and lymphoreticular neoplasia. Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions.


Inherited methemoglobinemia (enzyme deficiencies).


The metabolism in vitro and hepatic microsomal interactions of some enantiomeric drug substrates. 1. The metabolism in vitro and microsomal interactions of (+)-amphetamine, (-)-amphetamine, (+)-benzphetamine and (-)-benzphetamine were studied with hepatic microsomes from phenobarbitone-pretreated male rabbits. 2. (+)-Benzphetamine was N-demethylated 30-35% faster than (-)-benzphetamine, but the apparent Michaelis constants for the two enantiomers were similar. 3. (-)-Amphetamine was deaminated about 200% faster than (+)-amphetamine. 4. The benzphetamine enantiomers gave qualitatively and quantitatively identical type I microsomal difference spectra (peak, 390nm; trough, 425nm) indicating identical apparent binding affinities for microsomes and identical spectral changes at maxima (DeltaE(max.) values). 5. The amphetamine enantiomers gave qualitatively identical type II microsomal difference spectra (peak, 433nm; trough, 395nm). However, the type II spectral data indicated that (+)-amphetamine had a markedly higher apparent binding affinity than (-)-amphetamine for microsomes. The amphetamine enantiomers gave identical DeltaE(max.) values. 6. The benzphetamine enantiomers (0.5mm) enhanced the rate of microsomal cytochrome P-450 reduction by NADPH by 400-500%, (+)-benzphetamine enhancing the rate 20-25% more than (-)-benzphetamine. 7. The amphetamine enantiomers decreased the rate of microsomal cytochrome P-450 reduction by NADPH. At a concentration of 2mm, (+)-amphetamine decreased the rate more than (-)-amphetamine. 7. All four enantiomers enhanced microsomal NADPH oxidation.


Effects ov actinomycin D on the distal end regeneration in Hydra vulgaris Pallas.


The mechanism of blood vessel permeability derangement under the influence of histamine, serotonin and bradykinin.


The intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm. 1. A method is described for extracting separately mitochondrial and extramitochondrial enzymes from fat-cells prepared by collagenase digestion from rat epididymal fat-pads. The following distribution of enzymes has been observed (with the total activities of the enzymes as units/mg of fat-cell DNA at 25 degrees C given in parenthesis). Exclusively mitochondrial enzymes: glutamate dehydrogenase (1.8), NAD-isocitrate dehydrogenase (0.5), citrate synthase (5.2), pyruvate carboxylase (3.0); exclusively extramitochondrial enzymes: glucose 6-phosphate dehydrogenase (5.8), 6-phosphogluconate dehydrogenase (5.2), NADP-malate dehydrogenase (11.0), ATP-citrate lyase (5.1); enzymes present in both mitochondrial and extramitochondrial compartments: NADP-isocitrate dehydrogenase (3.7), NAD-malate dehydrogenase (330), aconitate hydratase (1.1), carnitine acetyltransferase (0.4), acetyl-CoA synthetase (1.0), aspartate aminotransferase (1.7), alanine aminotransferase (6.1). The mean DNA content of eight preparations of fat-cells was 109mug/g dry weight of cells. 2. Mitochondria showing respiratory control ratios of 3-6 with pyruvate, about 3 with succinate and P/O ratios of approaching 3 and 2 respectively have been isolated from fat-cells. From studies of rates of oxygen uptake and of swelling in iso-osmotic solutions of ammonium salts, it is concluded that fat-cell mitochondria are permeable to the monocarboxylic acids, pyruvate and acetate; that in the presence of phosphate they are permeable to malate and succinate and to a lesser extent oxaloacetate but not fumarate; and that in the presence of both malate and phosphate they are permeable to citrate, isocitrate and 2-oxoglutarate. In addition, isolated fat-cell mitochondria have been found to oxidize acetyl l-carnitine and, slowly, l-glycerol 3-phosphate. 3. It is concluded that the major means of transport of acetyl units into the cytoplasm for fatty acid synthesis is as citrate. Extensive transport as glutamate, 2-oxoglutarate and isocitrate, as acetate and as acetyl l-carnitine appears to be ruled out by the low activities of mitochondrial aconitate hydratase, mitochondrial acetyl-CoA hydrolyase and carnitine acetyltransferase respectively. Pathways whereby oxaloacetate generated in the cytoplasm during fatty acid synthesis by ATP-citrate lyase may be returned to mitochondria for further citrate synthesis are discussed. 4. It is also concluded that fat-cells contain pathways that will allow the excess of reducing power formed in the cytoplasm when adipose tissue is incubated in glucose and insulin to be transferred to mitochondria as l-glycerol 3-phosphate or malate. When adipose tissue is incubated in pyruvate alone, reducing power for fatty acid, l-glycerol 3-phosphate and lactate formation may be transferred to the cytoplasm as citrate and malate.


Graft versus host reactivity of embryonic lymphoid cells, activated by irradiated thymus and-or bursa cells.


Interrelationships between the contractile effects of metabolic substrates, beta-adrenergic blocking agents and endogenous catecholamine depletion on isolated rat atria.


Clinical cardiology. Use of anti-arrhythmic agents other than digitalis.


Neurotoxicity associated with a reaction to sulphasalazine.


Cutaneous vasculitis.

Cutaneous vasculitis.


Intramedullary blood flow through arthrodesis-treated joints.


Inhibition of [H3]serotonin uptake by the mouse spleen. A structure-activity study.


Contemporary practices in ophthalmology.


Derivatives of 3,4-dihydro-1(2H)-naphthalenone as beta-adrenergic blocking agents. I. Bunolol and related analogs.


Antimalarial sulfilimines and sulfoximines related to diaminodiphenyl sulfoxide and sulfone.


Evidence for a central noradrenaline receptor stimulation by clonidine.


An objective measure of induced aggression.


Depression and defensiveness in self-descriptive moods of alcoholics.


Prediction of rehospitalization of family-care patients using the MMPI.


Emotions profile index (EPI) pattern for paranoid personality types: cross-validation and extension.


Attitudes toward the mentally ill, knowledge of mental illness, and personal adjustment.


Note on prejudice and personality.

Note on prejudice and personality.


The Zollinger-Ellison syndrome, polyendocrine adenomatosis and other endocrine associations with peptic ulcer.


Control of homograft (allograft) rejection.


Host responses to malignant disease.

Host responses to malignant disease.


Effects of adrenergic blocking agents on gastric secretion and stress-induced gastric ulcer in rats.


Femoral vascular effects of some beta receptor adrenergic blocking agents.


Actions of dibenamine on adrenergic beta-receptors in cat's papillary muscle (molecular pharmacological studies on drug-receptor interaction systems in drug action IX).


Effects of reserpine and desipramine on the uptake and subcellular distribution of 5-hydroxytryptamine in rabbit brain stem after intravenous administration of 5-hydroxytryptophan.


Resistance of mechanical and electrical responses to hypogastric nerve stimulation to alpha-blocking agents in guinea-pig vas deferens.


Beta-adrenergic receptors in various organs.


Phthalic acid in the deep sea jellyfish Atolla.


Stimulation of fetal rat liver tyrosine aminotransferase activity in utero by 3':5'-cyclic nucleotides.


Reduced nicotinamide-adenine dinucleotide phosphate oxidase: activity enhanced by ethanol consumption. Prolonged consumption of ethanol enhances the activities of the hepatic microsomal ethanol oxidizing system and of reduced nicotinamide-adenine dinucleotide phosphate oxidase, but not of catalase. The oxidase-catalase system is not part of the microsomal ethanol oxidizing system since catalase inhibitors dissociate ethanol oxidation by the two pathways. Enhanced reduced nicotinamide-adenine dinucleotide phosphate oxidase activity may contribute to liver injury, possibly by favoring lipoperoxidation.


The neural ectodermal origin of the peptide-secreting endocrine glands. A unifying concept for the etiology of multiple endocrine adenomatosis and the inappropriate secretion of peptide hormones by nonendocrine tumors.


Antisocial personality type with cardiac lability.


Release of alpha imino acid as primary product in D-amino-acid oxidase reaction.


Effect of light on the purple complex of D-amino-acid oxidase.


Redistribution of intrarenal blood flow in the patients with chronic renal disease.


Cyclic 3'5'-AMP, its dibutyryl derivative and theophylline effects on the rat portal vein in vitro.


Influence of some adrenal steroids on hexobarbital and hydroxydione anaesthesia.


Adrenergic stimulating and blocking effects of 1-(o-chlorophenyl)-2-isopropylaminoethanol (isoprophenamine) on some isolated organs of guinea pigs and rabbits.


The effect of cardiac sympathetic blockade on the relationship between cardiac output and carbon dioxide tension in the anaesthetized dog.


The uterus-stimulating activity of the plasma of male rabbits before and after mating.


Torsion of the retained testicle in the dog.


Frequency-force relationship in the blood-perfused canine papillary muscle preparation.


The diagnostic value of routine electron microscopy of renal biopsies.


Direct action of Physalia toxin on frog nerve and muscle.


Platelet glycolytic enzymes: effect of cellular disruption procedures on activity.


Metabolic and biosynthetic features of lymphocytes from patients with diabetes mellitus: similarities to lymphocytes in chronic lymphocytic leukaemia.


Degree of repression and frequency of psychosomatic symptoms.


Sex of figure drawing in identifying practicing male homosexuals.


Repression of colony formation reversed by antiserum to mouse thymocytes. Marrow cells derived from C57BL/6 mice form many fewer splenic colonies in irradiated C57BL/6 x C3H F1 hybrid recipients than in irradiated C57BL/6 recipients (repression of colony formation). This effect is reversed by treatment of the hybrid recipients with active antiserum to mouse thymocytes. The repression phenomenon cannot readily be explained in immunological terms; hence the effect of the antilymphocyte serum on this phenomenon may not result from immunosuppression in the usual sense.


Inactivation of endoportally infused 5-hydroxytryptamine in rats pretreated with a monoamine oxidase inhibitor.


Sensorimotor functions, intelligence and cognition, and emotional status in subjects with cerebral lesions.


The formation and utilization of reducing power in aerobic chemoautotrophic bacteria.


Ferredoxins: chemistry and function in photosynthesis, nitrogen fixation, and fermentative metabolism.


Selective effects of testosterone and isoproterenol upon regenerating submandibular gland isografts in BALB-c mice.


What the pediatrician should know about children's teeth. I. Dental emergencies.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 41-1970.


Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Adenosine 3',5'-monophosphate-dependent protein kinase activity was found in about thirty sources including many mammalian tissues as well as species representative of eight different invertebrate phyla. The data support a unifying theory for the mechanism of action of adenosine 3',5'-monophosphate, namely that its many and diverse effects are mediated through activation of tissue-specific protein kinases.


Tolerance of rat skin grafts in adult mice. Adult CBA mice may be made tolerant of August rat tail skin grafts by short intensive treatments with antilymphocyte serum followed by massive ( approximately 100 x 10(6) cells) injections of August rat lymphoid cells. Prolonged tolerance can be achieved only in thymectomized mice, and is accompanied by lymphoid cell chimerism and the manufacture of rat protein. The rat lymphoid cell donors must be treated beforehand with antirat ALS to avoid complications associated with graft versus host reactions. Rejection of rat skin grafts is accompanied by the formation of high titres of antirat hemolysins and lymphocytotoxins, but in "tolerant" mice the rat skin survives in the continual presence of antirat antibodies. Under certain circumstances, however, passive transfusion of high titre mouse antirat serum can precipitate the breakdown of rat skin grafts. It is doubtful if this represents the primary mechanism of rejection. The reaction of normal mice against rat skin is essentially an intensified allograft reaction; it is at all events wholly immunological in character.


The electron transport system in nitrogen fixation by Azotobacter. II. Isolation and function of a new type of ferredoxin. A new type of ferredoxin was isolated from Azotobacter vinelandii cells. The protein was able to replace the native chloroplast ferredoxin in the photoreduction of nicotinamide adenine dinucleotide phosphate (NADP) and functioned as a reductant for the Azotobacter nitrogenase.


Studies of drug interaction.

Studies of drug interaction.


The influence of the ganglionic blocking agent ganlion on viscerovisceral and viscerocerebral reactions of the cat.


Genetic requirements for graft-versus-host reaction in mouse. Different efficacy of incompatibility at D- and K-ends of the H-2 locus.


Effect of chronic intake of ethanol on pyridine nucleotide levels in rat liver and kidney.


Practicing physicians are in short supply.


Blood lipids after the administration of beta-blockers.


Arteriography: principles and techniques.


Radiography of a non-functioning left half of a horseshoe kidney.


Meteorologic factors in the fallout of pollens and molds.


Neurogenic tumor of the mediastinum.

Neurogenic tumor of the mediastinum.


The private non-affiliated metropolitan community hospital: its responsibility as related to postgraduate medical education.


Statute of limitations in malpractice lawsuits.


Medical licensure: let's reciprocate.

Medical licensure: let's reciprocate.


Medical licensure: let's not reciprocate. Licensure problems in Illinois.


Paul R. Ehrlich: A biologist's remarks on the "population explosion".


Cardiac function and mean circulatory pressure in acute impediment to venous return.


Calcium binding, quantum yield, and emitting molecule in aequorin bioluminescence.


Environmental control of macromolecular synthesis in cartilage and bone: morphogenetic response to hyaluronidase.


Steroidogenesis in equine testis.

Steroidogenesis in equine testis.


The reimplanted lung.

The reimplanted lung.


Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.


Studies on the hormone-sensitive lipase of rat epididymal adipose tissue.


Effects of morphine treatment and starvation on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes.


Comparison of beta-adrenergic blocking effect of DCI, methoxamine, propranolol, MJ 1999, H 56-28, LB 46 and I.C.I. 50 172 on the chronotropic response to isoprenaline.


Purification of histamine receptor in cat small intestinal muscle. I. Specificity of labeling histamine receptor with radioactive dibenamine.


Beta-adrenergic blocking property of l-3-methoxy-omega-(1-hydroxy-1-phenylisopropylamino)-propiophenone-HCL (D 563) in femoral circulation.


Practolol (I.C.I. 50172), a beta-adrenergic receptor blocking agent, in the management of cardiac arrhythmias.


A ganglion-blocking action of the toxin isolated from Japanese ivory shell (Babylonia japonica).


Intermittent vs sustained steroid therapy.


Sterol metabolism. 8. Conversion of cholesterol 20 alpha-hydroperoxide to 20 alpha, 21- and 20 alpha, 22R-dihydroxycholesterol by adrenal cortex mitochondria.


Dietary induction of some enzymes of amino acid metabolism following the acute administration of aminoazo dyes.


Kinetic characteristics of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa.


On the loss of reduced and oxidised nicotinamide adenine dinucleotide phosphate added to suspensions of rat liver.


Action of actinomycin D on tryptophan uptake in the adrenalectomized rat and its effect on induction of tryptophan pyrrolase and tyrosine transaminase in liver.


The conversion of phytoene-14C to acyclic, monocyclic, and dicyclic carotenes and the conversion of lycopene-15,15'-3H to mono- and dicyclic carotenes by soluble enzyme systems obtained from plastids of tomato fruits.


Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation.


The metabolism of rat brain mitochondria. Preparation and characterization.


Dental caries in Eskimo children of the Keewatin District in the Northwest Territories.


A comparison of mosquito collection by Malaise and miniature light traps.


Swarming and mating of some California mosquitoes.


The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens.


Influence of hydrocoritsone and glucagon on liver tyrosine transaminase and on brain tyrosine, norepinephrine and serotonin.


Studies on tissue glycohydrolases appearing after infection of guinea pigs with Mycobacterium tuberculosis H37Rv.


Reform of medical education in Italy: Report and recommendations of two conferences.


Co-existent arteriosclerosis, PAN, and premature aging.


A modified actuarial method in the selection of medical students.


Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial.


Protection by catatoxic steroids against meprobamate.


Studies on the induction of nitroreductase activity by DDT and phenobarbital.


Cardiopulmonary effects of antimalarial drugs. 1. 4-Aminoquinolines: chloroquine quinetholate.


Anomalies of the internal organs and diminished calcification of vertebrae in fetuses after benzhydrylpiperazine treatment of pregnant rats.


Fetal edema from benzhydrylpiperazines as a possible cause of oral-facial malformations in rats.


Venezuelan equine encephalitis.

Venezuelan equine encephalitis.


Ferredoxin-reducing substance (FRS) from spinach. II. Separation and assay.


The problems of traumatic skin loss of the lower limbs, especially when associated with skeletal injury.


The effect of hydroxyzine on phenothiazine therapy.


Why does asthma occur at night?

Why does asthma occur at night?


The view box.

The view box.


Intermittent jaundice.

Intermittent jaundice.


The doctor-patient dyad: an interpersonal relationship model.


Argentaffine carcinoma (carcinoid tumor) involving the ampulla of Vater.


Community aspects of epilepsy.

Community aspects of epilepsy.


An analysis of 500 consecutive cases of acute appendicitis in a metropolitan charity hospital.


Biosynthesis of triglycerides from triose phosphates by microsomes of intestinal mucosa.


Triose phosphates as precursors of glyceride biosynthesis by rat liver microsomes.


Histamine and plasma kinins in delayed allergic skin reactions.


Prevention of urological complications after renal allotransplantation.


Studies on immunological competence of lymphoid cells from different lymphatic organs of rats in graft versus host reaction.


Free energy of cell differentiation.

Free energy of cell differentiation.


Molecular weights of hydra and planarian ribosomal RNA.


Tolerance to aortic valve homografts in man.


Molecular-scale drug entrapment as a precise method of controlled drug release. I. Entrapment of cationic drugs by polymeric flocculation.


Action of antibiotics on respiratory tract. II. Dicloxacillin.


The peabody picture vocabulary test: automated application in a statewide psychiatric system.


Propericiazine in the treatment of behavioural disturbances in children.


News in chemistry of psychotropic drugs in the year 1969.


Lung allografts in dogs treated with methotrexate and antilymphocyte serum.


Prevention of nicotine intoxication by catatoxic steroids.


Direct agonistic and antagonistic effects of ergotamine on vertebrate melanophores.


Isolation and some pharmacological properties of two biologically active substances of crown gall infected tomato plants. I. Isolation of the active substances: tomatine and gomatine.


Isolation and some pharmacological properties of two biologically active substances of crown gall infected tomato plants. II. Studies on the antihistamine-like effects of tomatine and gomatine.


Effect of acetoacetate on tyrosine metabolism in guinea-pigs fed a scorbutic diet.


A retrospective analysis of variables related to duration of treatment in a university psychiatric clinic.


Forty-second session of Federal Council.


Modification of ethanol effects by chlorcyclizine in the rat.


Nature of the water-soluble metabolites of 7,12-dimethylbenza(a)-anthracene formed by liver microsomes of normal and 3-methylcholanthrene-treated rats.


Ipecac may not halt drug abuse.

Ipecac may not halt drug abuse.


Current concepts: sialorrhea.

Current concepts: sialorrhea.


Giant-cell arteritis--a spectrum of disease.


[Studies of differentiation of nematocytes in Hydra attenuata Pall].


Pulmonary edema.

Pulmonary edema.


Apparatus for kinetic studies of the reactions of air revitalization chemicals with water vapor and gaseous carbon dioxide.


Kinetic studies on the ES-complex formation of p-hydroxybenzoate hydroxylase using the stopped-flow method.


Reduction of oxidized glutathione by xylitol.


Tricyclic norephedrine analogs. The isomeric 9-hydroxy-10-amino-1,2,3,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrenes.


Role of the benzyl moiety in biochemical and pharmacological processes.


New beta-adrenergic blocking agents. Cyclopropylphenyl derivatives.


Degradation of a pneumococcal type-specific polysaccharide with exposure of group-specificity. Pyruvic acid is an immunological determinant of the quite rigorously type-specific capsular polysaccharide of pneumococcal type IV (S IV). Removal of pyruvic acid by mild hydrolysis converts the capsular polysaccharide of type IV into an analog of the pneumococcal group-specific C-substance. Depyruvylated S IV resembles C-substance so closely immunologically that it not only precipitates a high proportion of the anti-C in antipneumococcal sera, regardless of their immunological types, but also, like C, precipitates human C-reactive protein in the presence of calcium ions. Apparently, the removal of pyruvic acid ketal rings from adjacent sugars unmasks N-acetylgalactosamine residues which must be linked and spaced much as are those in C-substance. Groupings reactive with suitably linked N-acetylgalactosamine, therefore, appear to be located on the surfaces of molecules of human C-reactive protein.


Acute bacterial conjunctivitis in Assiout, Upper Egypt. A one-year study.


Effects of beta-adrenergic blockade on the systolic time intervals.


Adenosine triphosphate: adenosine monophosphate phosphotransferase isozymes in rat liver and hepatomas.


Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. 3. Electron microscopy and analysis of the cytochromes. The membranous nature of pellets obtained from broken Escherichia coli spheroplasts by successive centrifugation at 3500 g (P(1)), 20,000 g (P(2)), and 105,000 g (P(3)), has been established by electron microscopy. Spectrophotometric analysis has shown that about 90% of the cytochromes are concentrated in the particulate fractions. The crude ribosomal pellet (P(3)) contained as much of the total cytochromes as did the pellet obtained at 20,000 g (P(2)). The high cytochrome content of P(3) is consistent with its high oxidative activity (1) and the presence of membrane vesicles in this fraction. Analysis at 77 degrees K intensified the optical extinction of all the cytochrome absorption bands, but the degree of intensification was not uniform for each fraction nor for each band within a given fraction. Carbon monoxide had little or no inhibiting effect on NADH oxidation. Reduced plus carbon monoxide difference spectra yielded artifactual absorption bands in the wave length regions where reduced vs. oxidized absorption bands normally occur. Succinate and NADH, either together or separately, reduced nearly all of the cytochromes, indicating that the cytochrome portion of the electron-transport chain is shared by both substrates. A tentative formulation of the electron-transport chain is presented.


A new class of sympathetic beta-receptor blocking agents. 3,4-dihydro-3-hydroxy-1,5-benzoxazocine.


Ultrastructure of synapses in a primitive coelenterate.


Initiation of sulfite oxidation by spinach ferredoxin-NADP reductase and ferredoxin system: a model experiment on the superoxide anion radical production by metalloflavoproteins.


The effects of aldosterone, angiotensin and electrolytes on kidney glucose-6-phosphate dehydrogenase.


New marine sterol possessing a side chain cyclopropyl group: 23-demethylgorgosterol.


Effect of lack of gravity on airborne infection during space flight.


The medical treatment of hypertension.

The medical treatment of hypertension.


Psychoendocrine study of oral contraceptive agents.


Conversion reactions in student aviators.


Circular dichroic and optical rotatory dispersion spectra of the threonine-inhibited aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Effects of ligand binding and protein denaturation.


Purification and properties of a phosphodiesterase from Avena leaf tissues.


Adult dental health in England and Wales in 1968. 2. Childhood attendance and adult dental health.


Atypical reasoning errors in sociopathic, paranoid, and schizophrenic personality types.


Inhibition of lipid synthesis and glucose-6-phosphate dehydrogenase in rat skin by dehydroepiandrosterone. Lipid synthesis from acetate-1-(14)C by rat skin was inhibited 44-56% by 2.5 x 10(-4) m dehydroepiandrosterone (DHA) in vitro with or without addition of glucose in the incubation medium. This inhibition affected all the lipid fractions examined (hydrocarbons, sterols, sterol esters, tri-, di- and monoglycerides, fatty acids, and polar lipids) and could be reversed by NADPH. DHA also inhibited lipid synthesis from glucose-U-(14)C and the formation of (14)CO(2) from glucose-1-(14)C, indicating interference with pentose cycle activity. Experiments with the 105,000 g supernatant fluid of rat skin homogenates demonstrated considerable activities of malic enzyme (ME) (12.6 nmoles of NADPH generated per min per mg of protein), of glucose-6-phosphate dehydrogenase (G6PD), and of 6-phosphogluconate dehydrogenase (6PGD) (17.5 nmoles of NADPH generated per min per mg of protein). G6PD was inhibited 98% by 2.5 x 10(-4) m dehydroepiandrosterone, while 6PGD and ME were not affected. It can be estimated from these data that the pentose cycle may contribute 41-57% of the NADPH needed for lipid synthesis in rat skin; the remainder of the necessary NADPH is presumably supplied by malic enzyme.


Shift toward anaerobic glycolysis in the regenerating rat kidney.


Enzymes of the uronic acid pathway in the human epidermis.


Effects of monoamine oxidase inhibitors, glyceryl gualacolate, and ethanol on experimental arterial thrombosis.


Histopathologic and ultrastructural study of allogeneic hepatic transplantation in isogenic rats.


Selective interactions with beta adrenergic receptors.


Characteristics of adrenergic receptors in lipid mobilization in the rat.


Nobel prize: 3 share 1970 award for medical research. 1. Von Euler and Axelrod.


Glutamate and gamma-aminobutyric acid in brain.


Nobel prize: 3 share 1970 award for medical research. 2. Katz.


Adrenergic receptors for metabolic responses in adipose tissue.


Pathways of fatty acid synthesis and reducing equivalent generation in mammary gland of rat, sow, and cow.


The inhibitory effects of endogenous NADPH-pyrophosphatase on the reduction of cytochrome c and the oxidation of drugs by liver microsomes.


Pharmacological characteristics of adrenergic receptors.


6 Beta-hydroxylation of triamcinolone acetonide by a hepatic enzyme system. The effect of phenobarbital and 1-benzyl-2-thio-5,6-dihydrouracil.


Biochemical aspects of the visual process. 8. Enzymatic conversion of retinylidene imines by retinoldehydrogenase from rod outer segments.


Adrenergic receptors for metabolic responses in skeletal and smooth muscles.


Insulin and adrenergic receptors.

Insulin and adrenergic receptors.


Purification and properties of glucose-6-phosphate dehydrogenase from rat kidney cortex.


Host and tumor modifications associated with serial heterotransplantation of tumors through immunologically tolerant animals.


Dihydroergotamine, propranolol and the beta adrenergic receptors of fat cells.


Cytochrome p450: the tip of another iceberg.


Circulatory effects of oxprenolol, a new beta-adrenergic blocking agent.


Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity.


Hydrazide-induced seizures and cerebral levels of gamma-aminobutyric acid: a re-evaluation.


Traumatic injuries of the hand and foot during combat.


Vasoactive drugs in treatment of shock.

Vasoactive drugs in treatment of shock.


Caries prevalence in crippled children--special emphasis on environmental variation.


Isocitrate dehydrogenase in mouse embryos: activity and electrophoretic variation.


Traumatic arterial spasm. An angiographic study in rabbits.


Recent advances in rheumatic diseases: 1967 through 1969.


2-tetrahydropyridylindoles as histamine and serotonin antagonists.


Influence of various drugs on accumulation of 3H-nicotine in isolated rat atria.


A bacteriological study of acute lower respiratory tract infections in infancy and childhood.


Role of antihistaminics in preventing systemic side effects of iron-dextran therapy.


Hypertension: the general practitioner's approach to the problem, with special reference to the use of methyldopa (Aldomet).


Muscle tension and effort at self-control during anxiety.


Response specificity among muscular and autonomic variables.


Unde et quo.

Unde et quo.


Observations on the mechanism of renin release by catecholamines.


Cinnarizine in cerebrovascular disease.

Cinnarizine in cerebrovascular disease.


Cardiopulmonary actions of 1-isopropylamino-3-(3-tolyloxy)-2-propanol hydrochloride: a new adrenergic beta receptor antagonist.


Podiatry's role in basketball.

Podiatry's role in basketball.


Treating more patients in less time.

Treating more patients in less time.


Human placental 17 beta-estradiol dehydrogenase. V. Purification and partial characterization of the diphosphopyridine nucleotide (triphosphopyridine nucleotide)-linked enzyme.


Rose Bengal as a specific photosensitizer for a histidine residue at the triphosphopyridine nucleotide binding site of 6-phosphogluconate dehydrogenase.


Biosynthesis of uridine diphospho-N-acetylmuramic acid. 3. Purification and properties of uridine diphospho-N-acetylenolpyruvyl-glucosamine reductase.


Localization and properties of hydroxypyruvate and glyoxylate reductases in spinach leaf particles.


Beta-adrenergic blockers.

Beta-adrenergic blockers.


Frog muscle responses to catecholamine beta-receptor blocking agents.


On the biosynthesis of glycerol ethers in mitochondria.


Purification of iodotyrosine deiodinase from bovine thyroid.


Changes in tumour inhibiting activity of allogeneic lymphoid cells derived from donors altered by the graft-versus-host reaction.


Resistance and susceptibility to tumours. IV. The temporary survival and rejection of the Ehrlich ascites carcinoma in xenogeneic hosts.


Allograft survival after treatment with antilymphocyte serum combined with immunosuppressive drugs.


Chromosome and sex-chromatin studies of patients with hypospadias.


Simulated alpha-blockade due to inhibition of release of nor-epinephrine by a beta-blocking agent Ko 592.


A new group of viruses in Jamaica. I. Initial studies.


Studies on the transmissibility of pathogenic-organisms to liver by larvae of liver fluke and hookworm.


The effect of beta-adrenergic receptor blockade on the atrial refractory period of hyperthyroid rabbits.


Separation of infectious canine hepatitis virus antigens: intact virions and empty capsids.


Some properties of pea enation mosaic virus.


Influence of the host system on the properties of Venezuelan equine encephalomyelitis virus.


Effects of beta-blocking agent Ko 592 in massive doses upon catecholamines in arterial tissue and plasma and peripheral blood flow in anesthetized dogs before and after electric stimulation of sympathetic ganglia.


Study of the antigenic structure of Coxiella burneti. VII. Properties of phenol-extracted phase I antigenic component.


Study of the antigenic structure of Coxiella burneti. 8. Immunogenicity of phenol-extracted phase I antigenic component.


Serological relationship of buffalopox virus to vaccinia and cowpox viruses.


A note on heat, chloroform and ether sensitivity of sheep pox and goat pox viruses.


Inhibitory effect of sera from patients with Botkin's viral hepatitis on the differentiation and mitotic activity of lymphocytes and integrity of their chromosomes in the course of serial passaging in vitro.


The use of rivanol treatment for removal from arbovirus antisera of nonspecific inhibitors of haemagglutination.


Determination of inorganic phosphate by the molybdovanadate method in the presence of ATP and some interfering organic bases.


Alterations in induction of tyrosine aminotransferase and tryptophan oxygenase by glucose pretreatment.


A comparative effect of central nervous system acting drugs on the open field performance in rats.


Contact dermatitis.

Contact dermatitis.


The innervation of the frog's heart. I. An examination of the autonomic postganglionic nerve fibres and a comparison of autonomic and sensory ganglion cells.


Properties and regulation of pyruvate carboxylase from Bacillus stearothermophilus.


The innervation of the frog's heart. II. The effects of axotomy on the adrenaline content of the sympathetic nerve fibres.


The innervation of the frog's heart. 3. Electronmicroscopy of the autonomic nerve fibres and their vesicles.


The thymus and circulating lymphocytes of mice.


Cryptorchidism, chest deformities, and other congenital anomalies in three brothers.


Beta-adrenergic receptors in the hypothalamus for learned and unlearned taste aversions.


Alpha-adrenergic receptors in hypothalamus for the suppression of feeding behavior by satiety.


Control of arteriovenous shunt flow.

Control of arteriovenous shunt flow.


The use of 2-chloroethanol for reversible depolymerisation of the protein shell of bacteriophage fr.


Direct and indirect transfer of ATP and ADP across the chloroplast envelope.


Change in sedimentation profile of protein synthesizing particles observed after protein synthesis.


Influence of pH on the stability of some aminoacyl transfer ribonucleic acids and their elution pattern in chromatography on columns of methylated albumin adsorbed on kieselguhr.


Advanced initiation of synchronous mitoses in physarum polycephalum following UV-irradiation.


Ascaris suum infection in calves. I. Clinical signs. Clinical signs consistent with those of atypical interstitial pneumonia (AIP) were induced in calves sensitized with infective Ascaris suum eggs at seven to 20 weeks of age and challenged at three-week intervals one or more times. These signs usually appeared on the sixth or seventh day postinfection and reached maximum severity between the tenth and 13th days following infection. Prominent signs were: dyspnea, often with expiratory grunt, coughing, mouth breathing and emphysema as well as increased respiration and heart rates. In general, the intensity of signs was dependent upon dose size, although a single small dose resulted in acute signs and death in one calf. Intermittent coughing and vesicular sounds were induced in calves given A. suum eggs continually over prolonged periods. No respiratory abnormalities resulted from challenge with Toxocara canis after sensitization with A. suum. Antihistamine therapy did not alter the clinical signs in A. suum infected calves.


Epoxides as obligatory intermediates in the metabolism of olefins to glycols.


Ascaris suum infection in calves. II. Circulating and marrow eosinophil responses. An increment in the number of circulating eosinophils occurred between the 11th and 14th days after infection with Ascaris suum and this increase was generally greater after a challenge infection. Continual infection with small numbers of A. suum eggs over prolonged periods resulted in circulating eosinophil levels which fluctuated and were dose-dependent. The per cent marrow eosinophils always increased after a primary infection and a greater increase usually followed a challenge infection. The maximum increment of marrow eosinophils occurred between the tenth and 12th days and preceded the rise in circulating eosinophils by 36 hours. Antihistamine therapy did not alter eosinophil responses to A. suum. Circulating eosinophilia was not usually reflected by drastic changes in differential white cell counts. However, an increase in total white cell count often followed infection with A. suum and frequently parallelled changes in eosinophil counts. Hemoglobin and P.C.V. values remained within normal limits in A. summ infected calves.


Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4 alpha-methyl sterol to a 4 alpha-carboxylic acid during cholesterol biosynthesis.


Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4,4-dimethyl sterol to a 4 beta-methyl-4 alpha-carboxylic acid during cholesterol biosynthesis.


Antihistamines.

Antihistamines.


NAD and NADP-dependent glutamate dehydrogenase in Hydrogenomonas H 16.


The substance with competence inducing activity interacts with DNA and produces a hyperchromic increase of optical density.


Content uniformity in rectal suppositories.


Steric aspects of adrenergic drugs.

Steric aspects of adrenergic drugs.


Detailed study of contaminant production in a space cabin simulator at 258 mm. mercury.


Effect of cooling on beta-receptor mechanisms in isolated saphenous veins of the dog.


Quantitation of the degree of antagonism of chloroquine to histamine, acetylcholine and serotonin (PA2 values).


Studies on heart anaphylaxis. IV. Effect of antigen and histamine on depressed isolated heart preparations.


Use of anti-arrhythmic agents other than digitalis.


Cyclacillin, a semisynthetic aminoalicyclic penicillin. I. Antibacterial activity in vitro and in vivo compared with ampicillin and cephalexin.


Metabolism and mentation.

Metabolism and mentation.


HCG stimulation test in prepubertal boys with cryptorchidism, in bilateral anorchia and in male pseudohermaphroditism.


The behaviour of sub-periodic Brugia malayi, Buckley and Edeson, in Anopheles gambiae, Giles and Aedes aegypti, Linnaeus.


Necrotizing angiitis associated with drug abuse.


[The organization of biologic membranes].


The thymus as an endocrine gland: properties of thymosin, a new thymus hormone.


Analysis of host and donor cell proliferation in chorioallantoic pocks.


A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.


Renal glomerular disease.

Renal glomerular disease.


Studies on some physicochemical properties of a thymus humoral factor conferring immunocompetence on lymphoid cells. By means of an assay of graft-versus-host activity some properties of the thymic humoral factor which confers immunocompetence upon lymphoid cells in vitro have been studied. Allogeneic and xenogeneic thymic preparations were found to activate lymphoid cells from neonatally thymectomized mice, enabling initiation of a graft-versus-host response. Thus, this thymus factor is apparently neither strain nor species specific. The active principle of calf thymus extracts was found to be in the supernatant after prolonged ultracentrifugation. When exhaustive dialysis and ultrafiltration through Diaflo membranes were performed, the active thymus agent was found to pass through both the dialysis sac and Diaflo UM-2 membranes. The molecule which confers immunocompetence upon lymphoid cells thus seems to be of molecular weight of an order of magnitude of 1000 or less. Dialyzed thymus preparations injected into neonatally thymectomized mice also restored the capacity of spleen cells of these mice to induce graft-versus-host activity. When injected into intact mice, thymus extract also increased the proportion of competent cells in the spleens of these animals, probably by activation of target cells originating outside the spleen.


Neuromuscular synapse: stochastic properties of spontaneous release of transmitter. The spontaneous quantal release of transmitter from the motor nerve endings is a random process which follows the Poisson theorem; the liberation of each quantum is independent of the release of previous quanta. Increase in the extracellular calcium concentration produces a statistical interdependence in the release of the spontaneously appearing packages.


Biochemical studies of bacterial sporulation and germination. XXII. Energy metabolism in early stages of germination of Bacillus megaterium spores.


A comparative study of butaperazine, chlorpromazine and placebo in chronic schizophrenics.


The pathogenesis of the vascular and glomerular lesions of rejection in renal allografts and their modification by antithromtotic and anticoagulant drugs.


The anxiety-depression syndrome.

The anxiety-depression syndrome.


Renal allograft rejection.

Renal allograft rejection.


Beta-receptor antagonists.

Beta-receptor antagonists.


Use of a new antidepressant in the female climacteric.


A study in vivo of adrenergic receptors in the rectum and in the internal and sphincter of the cat. THE SMOOTH MUSCLE SPHINCTERIC ACTIVITY OF THE ANUS IN CATS IS BASED ON TWO DISTINCT MECHANISMS: a typical anal component, characterized by anal slow pressure waves not related to spike potentials in the internal anal sphincter, and an intestinal-like pressure component related to spiking activity in the internal sphincter. Anal slow pressure waves are influenced by the activity of alpha excitatory receptors within the internal sphincter, whereas no conclusive data are available concerning the action of adrenergic beta receptors on this pressure component. Intestinal-like pressure waves and the correlated spiking activity in the internal anal sphincter are influenced by alpha and beta inhibitory adrenergic receptors. The rectal wall of the cat contains alpha and beta adrenergic receptors producing relaxation.


Ovarian function in uteroovarian homotransplantation.


The role of the phagocyte in host-parasite interactions. XXV. Metabolic and bactericidal activities of leukocytes from pregnant women.


Studies on the enzymatic composition of osmophilic yeasts.


The stimulation of the hexosemonophosphate shunt and glutathione reduction by chlorpromazine in the presence of a subcellular, particulate fraction of guinea pig brain.


Characterization of the particulate nitrite oxidase and its component activities from the chemoautotroph Nitrobacter agilis.


The cardiovascular pharmacology of bunolol, a new beta adrenergic blocking agent.


The possible role of brain monoamines in the acute toxicity of digitoxigenin.


Antiarrhythmic activity of bunolol, a new beta adrenergic blocking agent.


Ecdysones and synthetic analogs: Molting hormone activity and inhibitive effects on insect growth, metamorphosis and reproduction.


Immunosuppression and the Guillain-Barré syndrome.


Observations on the possible role of central mechanisms in acute digitoxigenin toxicity.


Psychotropics in anxiety and depression--combination or single agent?


The diagnosis game.

The diagnosis game.


Oxidation of 5 beta-cholestane-3alpha, 7alpha, 12alpha-triol by rat liver microsomes.


Caution in the use of ophthalmic technicians and assistants.


Subcellular localization of neurotransmitters and releasing factors in the rat median eminence.


Neurohumors and neurohormones: definitions and terminology.


Quantitative histochemistry of nicotinamide adenine nucleotides in human skin.


Catecholamines and tryptamines.

Catecholamines and tryptamines.


Subcellular distribution of neurohumors and chemical receptors in the central nervous system.


Quantitative determination of butaperazine by TLC.


Dermophilic insect repellents with perdurable efficacy.


Histamine synthesis and its inhibition in rabbit platelets in vitro.


Testosterone metabolism by gastrointestinal microsomes.


Kinetic studies of glutamate dehydrogenase. The reductive amination of 2-oxoglutarate. 1. Kinetic studies of the reductive amination of 2-oxoglutarate catalysed by glutamate dehydrogenase with NADH and NADPH as coenzyme were made at pH7.0 and pH 8.0. The concentrations of both substrates and coenzymes were simultaneously varied over wide ranges. Lineweaver-Burk plots with respect to each substrate and coenzyme were linear, except that with high concentrations of 2-oxoglutarate or coenzyme inhibition occurred. There was no evidence of the negative homotropic interactions between the enzyme subunits that were revealed in previous kinetic studies of the reverse reaction. 2. The initial-rate results are shown to be inconsistent with any of the six possible compulsory-order mechanisms for this three-substrate reaction, and it is concluded that a random-order mechanism is the most likely one. On the basis of this mechanism, the dissociation constants of all the binary, ternary and quaternary complexes of the enzyme and substrates are calculated from initial-rate parameters. 3. The results are discussed in relation to those of earlier workers who concluded that the mechanism is of the compulsory-order type.


Sedation for cataract surgery. Comparison of Carbrital and neuroleptanalgesia.


Safe mydriasis.

Safe mydriasis.


The effect of isoprenaline on adrenoceptors in human saphenous vein. 1. The order of potency of sympathomimetic amines in causing contraction of strips of human saphenous vein was (-)-adrenaline>(-)-noradrenaline>(-)-phenylephrine>(+/-)-isoprenaline.2. The competitive alpha-adrenoceptor blocking drugs tolazoline, phentolamine, and thymoxamine and the irreversible blocking drug phenoxybenzamine all blocked noradrenaline and isoprenaline contractions.3. Contractions produced by 5-hydroxytryptamine were also blocked by phentolamine and thymoxamine. Fenfluramine-induced contractions were not blocked by thymoxamine or phenoxybenzamine.4. ED50 contracting doses of isoprenaline did not cause consistent relaxation of noradrenaline-contracted strips.5. It is concluded that human saphenous vein contains a dominant population of alpha-adrenoceptors which can be stimulated by high doses of isoprenaline, but the occurrence of beta-adrenoceptors mediating relaxation is rare.


Effect of beta-haloalkylamines and ephedrine on noradrenaline release from the intact spleen of the cat. 1. The effects of beta-haloalkylamines, phenoxybenzamine (PBZ), N-alpha-naphthyl-methyl-N-ethyl-beta-bromoethylamine (SY28), N-cyclohexyl-methyl-N-ethyl-beta-chloroethylamine (GD131) and ephedrine on noradrenaline (NA) output following nerve stimulation were studied in the intact spleen of the cat. Postganglionic sympathetic nerves were stimulated at frequencies of 10 and 30 Hz for a total of 210 stimuli.2. PBZ and SY28 (10 mg/kg) increased the transmitter output at 10 Hz by nearly 5-10 times.3. Administration of GD131 (10 mg/kg) had no effect on output at either frequency. Phentolamine (3 mg/kg) given after GD131 increased NA output at 10 Hz.4. Ephedrine (0.5 mg/kg) caused no changes in catecholamine output, while higher doses of ephedrine (10-20 mg/kg) increased the amount released at 10 Hz.5. Perfusion of the spleen with Krebs-bicarbonate solution containing either SY28, GD131 or ephedrine (10 mug/ml) increased the recovery of infused NA by 80-90%.6. It is concluded that presynaptic as well as postsynaptic events determine the overflow of NA following stimulation of sympathetic nerves of the spleen.


Relaxations of the isolated portal vein of the rabbit induced by nicotine and electrical stimulation. 1. A pharmacological analysis of the inhibitory innervation of the isolated portal vein of the rabbit has been made.2. In untreated preparations, transmural stimulation elicited a long-lasting relaxation at low frequencies (0.2-1 Hz); at higher frequencies a contraction followed by a prolonged after-relaxation occurred. Tetrodotoxin abolished the contractions but a higher dose was required to abolish the relaxations. Veratrine lowered the threshold of stimulation for producing relaxations in the untreated vein. The relaxations were unaffected by hyoscine or hexamethonium. They were reduced or altered by antagonists of alpha-adrenoceptors for catecholamines and by adrenergic neurone blockade. They were sometimes slightly reduced by antagonists of beta-adrenoceptors.3. In the presence of antagonists of alpha-adrenoceptors, electrical stimulation elicited relaxations which increased with frequency of stimulation and became maximal at 20-30 Hz. These relaxations were partially reduced by antagonists of beta-adrenoceptors, or by adrenergic neurone block; the antagonisms were more pronounced at the higher frequencies of stimulation. Noradrenaline also caused relaxations which were abolished by beta-adrenoceptor blocking drugs. Cocaine increased the sensitivity to noradrenaline by 7-8 fold after alpha-adrenoceptor blockade but had little or no effect on the relaxations induced by electrical stimulation at high frequencies.4. In the presence of antagonists of alpha- and beta-adrenoceptors, or adrenergic neurone blocking agents, or in veins taken from rabbits pretreated with reserpine, electrical stimulation elicited rapid relaxations which were greatest at 20-30 Hz. These relaxations were increased by veratrine and abolished by tetrodotoxin or by storing the vein for 9 days at 4 degrees C. They were unaffected by antagonists of acetylcholine, or by dipyridamole.5. Prostaglandins E(1), E(2) and F(2alpha) inhibited contractions elicited by electrical stimulation and noradrenaline, but in higher doses caused contractions themselves.6. Nicotine (10(-6)-10(-5) g/ml) relaxed the portal vein; higher concentrations elicited mixed inhibitory and excitatory effects. All these effects were abolished by tetrodotoxin, cocaine, hexamethonium or storage. The contractor effects were abolished by drugs or procedures that blocked adrenergic mechanisms.7. The relaxations produced by nicotine in untreated preparations and in veins from rabbits pretreated with reserpine were mediated mainly by a non-adrenergic non-cholinergic nervous mechanism. Relaxations induced by nicotine in the presence of antagonists of a-adrenoceptors were only partially antagonized by antagonists of f3-adrenoceptors.8. It was concluded that all the effects of nicotine and transmural stimulation were mediated by nerves. Part of the inhibitory effects was mediated by non-adrenergic, non-cholinergic nerves.


Adrenoceptors in the cat choledochoduodenal junction studied in situ. 1. The effects of adrenaline, noradrenaline, isoprenaline and terbutaline (PINN), 1-(3,5-dihydroxyphenyl)-2(t-butylamino)-ethanol, on the sphincter of Oddi were studied in anaesthetized cats. Both adrenaline and noradrenaline (1-4 mug/kg) increased resistance to flow through the sphincter. This effect was blocked by dibenamine (0.5-2.5 mg/kg) and by phenoxybenzamine (0.5-1.0 mg/kg).2. Isoprenaline (0.5-5.0 mug/kg) as well as terbutaline (0.5-10.0 mug/kg) inhibited the spontaneous sphincter activity and decreased flow resistance. In these doses, isoprenaline provoked marked tachycardia and relaxation of the duodenum, whereas the cardial and intestinal effects of terbutaline were minimal. The effects were blocked by propranolol (0.5-1.0 mg/kg).3. The results confirm earlier observations of the presence of alpha-adrenoceptors active in contraction of the sphincter musculature and of beta-adrenoceptors active in its relaxation. It is suggested that the beta-adrenoceptors belong to the beta(2) type according to Lands' classification.


A quantitative study of beta-adrenergic receptors in rabbit atria.


Influence of the optical isomers of some centrally acting drugs  on norepinephrine responses.


Increased plasma renin activity induced in rats by physostigmine and effects of alpha- and beta-receptors blocking drugs thereon.


A selective beta-adrenoreceptor stimulant (Th1165a) related to orciprenaline.


Effective doses of some cholinolytics in the treatment of anticholinesterase poisoning.


Binding aspects of D-amino-acid oxidase with various carboxylic acids.


Actions of amino acids and convulsants on bulbar reticular neurones.


Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. 3. Properties of homoserine dehydrogenase.


Multivalent regulation of glutamic dehydrogenases from fungi. Effects of adenylates, guanylates, and acyl coenzyme A derivatives.


Transformation of testosterone into 17 beta-hydroxy-5 alpha-androstan-3-one by microsomal preparations of human skin.


Liver cytosol tyrosine aminotransferase. Product inhibition and interaction with substrates.


Stereospecificity of hydrogen transfer reactions of the Pseudomonas aeruginosa pyridine nucleotide transhydrogenase.


Local effects of beta-adrenergic blocking drugs in asthmatics.


Reactivity of the bronchial tree to different stimuli.


Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. 8. Inductions by hydrocortisone and insulin in cultured hepatoma cells.


Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. IX. Studies of the mechanisms of hormonal inductions in cultured hepatoma cells.


The secretion of fluid by the testes of rats, rams and goats with some observations on the effect of age, cryptorchidism and hypophysectomy.


Action of antihistamines on the endometrium and the histamine theory of decidual induction.


Adrenergic blockade and the corticosteroid and growth hormone responses to methylamphetamine.


Enhancement of the pre-irradiation action of TAB.


Pulmonary lesions with eosinophilia.

Pulmonary lesions with eosinophilia.


Treatment of respiratory failure.

Treatment of respiratory failure.


Inhibition of carbohydrate breakdown in brain by adrenergic beta-receptor blocking drugs: comparison of INPEA and propranolol.


Autonomic control of insulin secretion and the treatment of heart failure. To investigate the role of the autonomic nervous system in controlling insulin secretion 13 normal subjects and 5 patients with heart failure underwent insulin secretion tests. Alpha-adrenergic stimulation and beta-receptor blockade significantly depressed the secretion of insulin in response to intravenous tolbutamide in normal subjects, while both alpha-blockade and beta-stimulation significantly increased the insulin secretion response in both normal subjects and patients in heart failure. Parasympathetic stimulation and blockade had no significant effect on the insulin secretion response. These findings suggest that drugs that block the alpha-adrenergic receptors or stimulate the beta-adrenergic receptors by their ability to counteract the insulin suppression resulting from increased sympathetic nervous activity may play a vital metabolic part in the deranged metabolism of the failing heart in addition to their direct haemodynamic benefits.


Controlled trial of oxprenolol and practolol in hypertension. In controlled trials of the beta-adrenergic blocking drugs oxprenolol and practolol in hypertension both drugs were well tolerated without side effects and caused statistically significant non-postural reduction of blood pressure. In less than half the patients on eitherdrug the reduction of blood pressure was clinically adequate. No attempt was made to compare the two drugs.


Oscillatory behaviour of enzymic reactions: a new phenomenon.


Antagonism of hypotensive action of bethanidine by "common cold" remedy.


Investigations on the specificity of the so-called analgesic activity of non-narcotic drugs.


3H-normetanephrine uptake in rat brain slices. Relationship to extraneuronal accumulation of norepinephrine.


Reflex vascular responses to vasoactive substances.


Catecholamine accumulation in tissues of thiamine-deficient rats after inhibition of monoamine oxidase.


Meningoencephalitis following an influenza vaccination.


F1 hybrid animals: reactivity against recognition structures of parental strain lymphoid cells.


Biological aspects of collagenous homografts.


Tympanic membrane homografts in ear surgery.


Nature of cardiovascular decompensation during hemorrhagic hypotension.


Effects of 5-methoxytryptamine derivatives on reserpine-syndrome in mice.


Changes in pre- and postcapillary resistance in pathogenesis of hemorrhagic shock.


Inhibition of tyrosine transaminase by homogentisate and benzoquinoneacetate.


The role of neurohumours in early embryogenesis. 3. Pharmacological analysis of the role of neurohumours in cleavage divisions.


Enzymic reduction of long-chain acyl-CoA to fatty aldehyde and alcohol by extracts of Clostridium butyricum.


Tyrosine transaminase induction by dexamethasone in a new rat liver cell line. A cell line derived from normal, adult rat liver has been established; the cells are similar to hepatocytes, as shown by electron microscopy. The addition of dexamethasone to the culture medium induced a three- to sixfold increase in the specific activity of tyrosine alpha-ketoglutarate transaminase; this increase was inhibited by the simultaneous addition of cycloheximide or actinomycin D. The latter, when added to cells given prior treatment with dexamethasone, further enhanced the transaminase activity. Contact-inhibited cells showed a lower response to dexamethasone than exponentially growing cells.


Contribution of hypercapnia and hypoxia to the vascular response to ischaemia.


Estrogen-neurons and estrogen-neuron systems in the periventricular brain.


Structure and function of the median eminence.


Epidemiologic studies of possible cross protection between dengue and St. Louis encephalitis arboviruses in Florida.


Adrenergic beta receptors in vas deferens.


The imino acid content of the connective tissue of virgularia sp. (Cnidaria) and Triphyllozoon benemunitum nov-nov (Polyzoa).


Upper urinary tract abnormalities associated with cryptorchidism.


Respiratory metabolism of a "petite negative"yeast Schizosaccharomyces pombe 972h-. The respiratory metabolism of Schizosaccharomyces pombe 972h(-), a fission, haplontic, "petite negative" yeast, was studied. Glucose and glycerol are good growth substrates and are oxidized under appropriate conditions. l-Lactate, ethanol, malate, and succinate are oxidized but are poor substrates for growth. d-Lactate and pyruvate are neither oxidized nor used for growth. Limited growth was observed under anaerobic conditions. The addition of 0.3% KNO(3) to a rich medium relieves the oxygen requirement. A continuous increase of cell respiration during growth on repressive concentration of glucose was observed, suggesting the presence of glucose repression of respiration. Reduced nicotinamide adenine dinucleotide (NADH), succinate, alpha-glycerophosphate, and ascorbate plus tetramethyl-p-phenylenediamine are oxidized by a mitochondrial fraction. NADH and succinate oxidations are inhibited by antimycin A and NaCN but not by rotenone, suggesting the absence of the phosphorylation site I and the presence of sites II and III. The effects of several mitochondrial inhibitors on growth and respiration indicate that the requirement of an oxidant for growth is related neither to the functioning of the respiratory electron transport chain nor to the formation of respiratory energy. The previously suggested correlations between the nonviability of vegetative "petites" mutants, the absence of repression of respiration by glucose, and the incapacity to grow under anaerobic conditions are thus not strictly valid for S. pombe.


Triggering of the stomach eversion reflex of Acanthaster planci by coral extracts.


Locomotory response of Acanthaster planci to various species of coral.


Incorporation of CO2 into coral skeleton.


Reactive perforating collagenosis.

Reactive perforating collagenosis.


Mechanism of action of luteinizing hormone.


Cutaneous periarteritis nodosa.

Cutaneous periarteritis nodosa.


Local vascular changes induced by the cocarcinogen, phorbol myristate acetate.


Adrenergic regulation of insulin secretion during fasting in normal subjects.


A comparative study of germ cell kinetics in the testes of children with unilateral cryptorchidism: a preliminary report.


Moderator-variable effect on personality-test-item endorsements of physically disabled patients.


The use and abuse of beta-adrenergic blockade in the surgery of hyperthyroidism.


The South Australian school canteen programme: an interim report.


Effects of plastic-foil-occlusion on psoriatic lesions.


Suicide of the spouse as a divorce substitute.


Role of glutathione in regulation of hexose monophosphate pathway in Ehrlich ascites tumor cells.


Nitrogen metabolism in the perfused rat liver.


Nicotinamide adenine dinucleotides in the convulsant rat brain.


Malignancies in mainland Tanzania: squamous cell carcinomas.


Leishmanin skin sensitivity in northwestern Mali.


Diplococcus pneumoniae bacteremia.

Diplococcus pneumoniae bacteremia.


Lymphocytes in immunobiology.

Lymphocytes in immunobiology.


An enzymic method for determination of inorganic pyrophosphate and its use as an assay for RNA polymerase.


Fluorometric assay of amino acids.

Fluorometric assay of amino acids.


A sensitive fluorometric assay for amino acid oxidases.


Immunological similarity between NADH-cytochrome c reductases of mitochondrial outer membrane and microsomes.


Induction of alanine transaminase by adrenal steroids in cultured hepatoma cells.


Holography and holographic interferometry: industrial applications.


Metabolism of parathion by two species of Rhizobium.


Repellents against mosquitoes in Thailand.


Synergistic effects of adrenaline and mepyramine on the anaphylactic reactions of the bronchi and pulmonary vessels in the guinea pig heart-lung-preparation.


Metabolism of metyrapone by a soluble enzyme system in rat liver.


Beta-galactoside transport in bacterial membrane preparations: energy coupling via membrane-bounded D-lactic dehydrogenase. The transport of beta-galactosides by isolated membrane preparations from Escherichia coli strains containing a functional y gene is markedly stimulated by the conversion of D-lactate to pyruvate. The addition of D-lactate to these membrane preparations produces a 19-fold increase in the initial rate of uptake and a 10-fold stimulation of the steady-state level of intramembranal lactose or thiomethylgalactoside. Succinate, DL-alpha-hydroxybutyrate, and L-lactate partially replace D-lactate, but are much less effective; ATP and P-enolpyruvate, in addition to a number of other metabolites and cofactors, do not stimulate lactose transport by the vesicles. Lactose uptake by the membrane preparations in the presence of D-lactate requires oxygen, and is blocked by electron transport inhibitors and proton conductors; however, uptake is not significantly inhibited by high concentrations of arsenate or oligomycin. Furthermore, the P-enolpyruvate-P-transferase system is not involved in beta-galactoside transport by the E. coli membrane vesicles. The findings indicate that the beta-galactoside uptake system is coupled to the membrane-bound D-lactic dehydrogenase via an electron transport chain but does not involve oxidative phosphorylation.


The degeneration contraction of a sympathetically innervated smooth muscle in the rat after reserpine, inhibition of monoamine oxidase or tyrosine hydroxylase.


"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme.


Regulation of liver tyrosine aminotransferase activity in inbred strains and mutant mice. II. Studies on the starvation-induced enzyme adaptation.


An acute allergic inflammation in the rat.


Immunity and paralysis in mice. Serological and biological properties of two distinct antibodies to type III pneumococcal polysaccharide.


Use of neomycin blood agar with the optochin disk for rapid identification of pneumococci.


Timely topics in microbiology: gram positive bacteria, 1967-1969.


Isolated polyarteritis nodosa of the gallbladder.


Growth inhibition of tumour implants by associated surface active agents. Whereas dilute solutions of surface active agents modify the properties of cell membranes, particularly in relation to their electrical behaviour, moderate and strong solutions provoke more serious structural damage of the membrane, leading to an increase of its permeability and, finally, to cytolysis. These phenomena have inspired some authors to apply detergents as possible cancer chemotherapeuticals so far, however, with only poor results. The disintegrating effect of tumour emboli into single cells by certain detergents, and the ingenious discovery that the mutual adhesiveness between cancer cells is much less than between normal cells, have led the present authors to investigate the action of some biological surface active agents, alone as well as in some of their associations on the "take" of Yoshida sarcoma implants. Certain associations showed, in contradistinction to the separately applied components, surprisingly favourable activity. It could be established that a correlation actually exists between inhibitory effect and surface activity.


Multiple congenital skin webbing with cutis laxa.


Environmental influence on experimental teratocarcinogenesis in testes of mice.


Hemodynamic effects of phenoxybenzamine in anesthetized dogs. Our studies demonstrated that phenoxybenzamine, 10 mg/kg, administered intravenously to intact anesthetized dogs, produced an immediate and significant increase of heart rate and cardiac output. In heart-lung preparations, phenoxybenzamine had no effect or a negative cardiac inotropic effect, hence these actions were not related to direct cardiac action or to release of myocardial norepinephrine stores. Serial estimations of arterial blood catecholamines after phenoxybenzamine showed an increase of epinephrine and norepinephrine; the peak values of these catecholamines did not correlate well with the maximum cardiac output responses. Ganglionic blockade largely eliminated the early cardiac effects of phenoxybenzamine, hence its action did not appear to be upon peripheral terminals of postganglionic sympathetic or parasympathetic nerves. Phenoxybenzamine was found to have antivagal actions which might account for some of the delayed cardiac acceleration. When beta adrenergic receptor blockade was induced by sotalol, the cardiac effects of phenoxybenzamine were largely eliminated. Baroreceptor denervation prevented the increase of cardiac output after phenoxybenzamine. These observations are consistent with the concept that the increase of cardiac rate and output produced by phenoxybenzamine is principally mediated by baroreceptor reflexes acting through sympathetic cardiac nerves or circulating catecholamines.


Automated fluorimetric techniques based on NAD- and NADP-linked enzyme systems in the study of intermediary carbohydrate metabolism.


Some psychological effects of cosmetics.


Dogmatism, religiosity and mental health in college students.


Personality test configurations in acne vulgaris.


Cognitive innovation and stimulus-seeking: a study of the correlates of the Obscure Figures Test.


Cardiac replacement: current status of cardiac transplants and prostheses.


The significance of heart-binding antibody in human cardiac rejection.


Studies on the biosynthesis and degradation of sphingosine bases.


On the chemistry and occurrence of sphingolipid long-chain bases.


Physician support personnel in the 70's--economic implications.


The California "physicians' assistants" law.


The physiology of the synthesis of amino acids and their movement into the seed proteins of plants.


Types of pneumococci found in blood, spinal fluid and pleural exudate during a period of 15 years (1954-1969).


Spontaneous development of tyrosine aminotransferase activity in fetal liver cultures.


Induction of a previously non-inducible enzyme in Morris hepatoma 9618A.


Ecological aspects of common dermatoses in Thailand.


Scleritis and aortic incompetence. Two manifestations of connective tissue disease.


Characterization by transformation of an ampicillin-resistant mutant of pneumococcus.


In vivo restoration of the biological activity of transforming DNA inactivated by 32P disintegration.


The effect of some vasoactive agents on portal hypertension.


The influence of adrenergic and some other cardioactive drugs on electric activity of the isolated frog atrium.


The influence of the adrenergic drugs on the electrical responses of the rabbit isolated heart atrium.


Some aspects of carbohydrate metabolism in ripening mangoes.


Studies on immunological paralysis. 3. Recirculation and antibody-neutralizing activity of 14C-labelled type 3 pneumococcal polysaccharide in paralysed mice.


Pediatric assistants in the seventeenth century.


Effect of glucose, galactose, and different nitrogen-sources on the activity of yeast glutamate dehydrogenase (NAD and NADP-linked) from normal strain and impaired respiration mutant.


Effect of cold storage on the response of guinea-pig taenia coli to certain catecholamines and other agents.


Treatment of the poisoned child.

Treatment of the poisoned child.


Hidden hypercapnia in hemorrhagic hypotension.


Metabolic effects of catecholamines in sheep.


Comparison of erythrocyte 6-phosphogluconate dehydrogenases of man and various ungulates.


Uptake of glycine and release of nucleoside-polyphosphates by Zooxanthellae.


The selective action of antilymphocyte serum on recirculating lymphocytes: a review of the evidence and alternatives.


Central hypotensive effect of L-3,4-dihydroxyphenylalanine in the rat.


Self-preparation stannous fluoride prophylactic technique in preventive dentistry: report after two years.


The effects of calcium on adrenergic neuron blockade.


Reduction of gastric acid secretion and ulcer formation by 3,3-dimethyl-1-(3-methylaminopropyl)-1-phenylphthalan (Lu 3-010); an inhibitor of noradrenaline uptake.


The influence of protein binding on the excretion of some sulphanilamidopyrimidines in man.


The effect of sodium salicylate on the release of acid phosphatase activity from rat liver lysosomes in vitro.


The relative purgative activities of 1,8-dihydroxyanthracene derivatives.


Moisture uptake and tensile strength of bulk solids.


A stability study of chloramphenicol in topical formulations.


The polymorphism of aspirin.

The polymorphism of aspirin.


A borax-chloramphenicol complex in aqueous solution.


Treatment of adjuvant arthritis with antibradykinin drugs.


Inhibitory effect of p-hydroxyphenylisopropylarterenol on the isolated human myometrium.


Effect of some arrhythmogenic agents upon the acetylcholine content of the rabbit atria.


Effect of apomorphine and pimozide on synthesis and turnover of labelled catecholamines in mouse brain.


Individual elution of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine from a single, strong cation exchange column, by means of mineral acid-organic solvent mixtures.


Inhibitory effect of propranolol on the vasoconstrictor response to sympathetic nerve stimulation.


Reduced variation of [3H]noradrenaline uptake into rat submaxillary glands by atropine pretreatment.


Effects of induced sodium gradients on the transport of metaraminol.


The binding of neurohypophysial hormones in van Dyke protein.


Inhibition by p-chloroamphetamine of the conversion of 5-hydroxytryptamine to 5-hydroxyindoleacetic acid in rat brain.


A simple method for the simultaneous recording of blood pressure and heart rate.


Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogs.


Potentiation by amantadine hydrochloride of L-dopa-induced effects in mice.


Alteration of rat skin acid and alkaline phosphatase and beta-glucuronidase activity after topical application of fluocinolone acetonide cream.


Intestinal blood flow and absorption of non-dissociable substances.


Inhibition by propranolol of ethanol-induced narcosis.


Insulin tolerance in thiamine-deficient rats.


Acetylcholine release from cortical brain slices of rats injected with lithium.


Response to social and monetary reward in neurosis.


Action of cobalt compounds on vascular permeability, mast cells and blood clotting in rats and rabbits.


Drug addiction prevention program.

Drug addiction prevention program.


The presence of a monooxygenase system in human fetal liver microsomes.


Pneumococcal antibodies in IgA of serum and external secretions.


Successful bone marrow transplantation in a patient with humoral and cellular immunity deficiency.


Biochemical characteristics of microsomal preparations from diazinon-resistant and -susceptible houseflies.


Genetics of audiogenic seizures. 3. Time response relationships between drug administration and seizure susceptibility.


Mechanism of cholestasis. 1. Effect of bile acids on microsomal cytochrome P-450 dependent biotransformation system in vitro.


Quantitative estimation of the urinary sediment after renal transplantation.


Fine structure of growing cellulose fibrils of Ochromonas malhamensis Pringsheim (syn. Poteriochromonas stipitata Scherffel).


Comparison of the influence of spermidine and monovalent salts on RNA synthesis.


Influence of chloramphenicol in irradiated bacteria.


The watersplitting system of photosynthesis. I. A postulated model.


Role of dietary magnesium in the metabolism of drugs by NADPH-dependent rat liver microsomal enzymes.


Release of norepinephrine and normetanephrine from cat brain by central nervous system stimulants.


Isolation of C-reactive proteins of man, monkey, rabbit and dog by affinity chromatography on phosphorylated cellulose.


Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in coelenterates.


Pentylenetetrazol and ethamivan effects on brain serotonin metabolism.


The effects of Ca++ ions on the C14-catecholamine biosynthesis from C14-tyrosine in slices from the striatum of rats.


Possible effects of space cabin environments on drugs.


Inhibition of hepatic microsomal mixed function oxidases by D2O.


Neuromuscular disorders in rheumatoid arthritis. A motor-point muscle biopsy study.


Inhibition of mitochondrial electron transport by nor-dihydroguaiaretic acid (NDGA).


Interaction of a new antiphlogistic drug with histamine, bradykinin and tissue kinins.


Enhancement of tyrosine transamination in vivo by catecholamines.


Successful treatment of "drinamyl" addicts and associated personality changes.


Molecular orbital studies on the conformation of gamma-aminobutyric acid and muscimol.


Dental health status of students at the North Carolina advancement school.


Dental needs of the chronically ill and aged.


The oral health of narcotic addicts.

The oral health of narcotic addicts.


Etiology and pathogenesis of traumatic dental injuries. A clinical study of 1,298 cases.


Anesthetic management of an incompletely controlled hyperthyroid patient for thyroidectomy.


Flavoenzyme catalysis.

Flavoenzyme catalysis.


Control of enzyme levels in animal tissues.


Premarital sexual behavior, attitudes, and emotional adjustment.


Personality variables and the effectiveness of techniques to facilitate creative problem solving.


Physicians' assistants: an opinion.

Physicians' assistants: an opinion.


Transient-state intermediates involved in the hydride transfer step of the glutamate dehydrogenase reaction.


The degradation of hydroxy-L-lysine in liver via its phosphate ester.


Ferredoxin dependent CO-2 reduction to formate in Clostridium pasteurianum.


Does reduced nicotinamide adenine dinucleotide phosphate have a dual function in steroid hydroxylation reactions in adrenal mitochondria?


Plasma propranolol levels in the quaniitative assessment of beta-adrenergic blockade in man. Plasma propranolol levels associated with reductions in endogenous and exogenous cardiac beta-stimulation were determined in normal people. The levels associated with a given degree of blockade of exercise-induced tachycardia were about three times greater after intravenous administration than after oral administration. This shows that an active metabolite of propranolol is formed only after the drug is taken by mouth. The greatest reduction in the tachycardia of strenuous exercise was associated with plasma levels of 40 ng./ml. with oral administration and 100 ng./ml. with intravenously administered propranolol.The effect on isoprenaline-induced tachycardia following intravenously administered propranolol showed that the dose ratio for isoprenaline was about 30 with plasma levels of 100 ng./ml. and 10 with levels of 10-20 ng./ml. These plasma levels give 100% and 20-30% blockade of exercise-induced tachycardia. These findings suggest that some of the therapeutic effects of propranolol may be unrelated to beta-adrenergic blockade.


Oxidation of branched-chain fatty acids in rat liver homogenates.


Relative radio-sensitivity of different cell-types in Hydra.


Vocational training. Ancillary workers.

Vocational training. Ancillary workers.


Comparison on interferon production in mouse leukocytes by statolon and a complexed polyribonucleotide (poly I:C).


Interference activity of animal adenoviruses in chick embryo cell cultures.


Studies on the possibly digitoxin-sensitive phase of poliovirus-host cell interaction.


Infection of rabbit alveolar macrophages with a neurotropic vaccinia virus strain in vitro.


Multiplication of lymphocytic choriomeningitis virus in various systems.


Infection of rabbit alveolar macrophages with a dermotropic vaccinia virus strain in vitro.


Pathogenesis of herpetic encephalitis in cortisone-treated mice.


Infection of insect cells with Coxiella burneti.


Analysis of sialic acid present in some serum myxovirus inhibitors of glycoprotein nature.


Enhancement of interferon synthesis by polyinosinic-polycytidylic acid in L cells pretreated with interferon.


Inhibitory effect of n-methyl-N(2-hydroxyphenyl)N'-benzylthiourea on multiplication of poliovirus in cell cultures.


Detection of viraemia in acute respiratory disease of man.


Experimental infection of rhesus monkeys with Uukuniemi virus.


Comparative study of chromosome aberrations in cell cultures induced by tumorigenic and non-tumorigenic adenoviruses.


Isolation of a new arbovirus strain (Kemerovo group) from Ixodes ricinus ticks in the South-western region of Romania.


Non-serological methods for the initial classification of newly isolated arboviruses.


Investigations on mouse-adapted scrapie virus.


Improved method of preparing phase II Coxiella burneti antigen for the microagglutination test.


Emotional expression, memory and feelings during and after interviews with drugs.


Strength of H-2 and non-H-2 antigens as compared in ALS-suppressed recipients.


Strength of the tumour-specific antigens and of the "hybrid effect" of three chemically-induced sarcomas of the same inbred strain origin.


Relative strength of the male-specific antigen.


Comparison of colony-forming performance of bone marrow cells in syngeneic and allogeneic cellular environment within a single host.


The effect of antilymphocyte serum on graft-versus-host reactivity.


Studies on the kinetics of cytochrome P-450 reduction in rat liver microsomes.


The effect of Listeria monocytogenes on resistance to  pneumococcal infection.


Effect of heavy metals on dental caries and tooth eruption.


A clinical comparison of fluoride and antienzyme dentifrices.


Phenylketonuria--oral manifestations.

Phenylketonuria--oral manifestations.


Hexose-6-phosphate dehydrogenase: distribution in rat tissues and effect of diet, age and steroids.


L-phenylalanine ammonia-lyase. IV. Evidence that the prosthetic group contains a dehydroalanyl residue and mechanism of action.


Effects of hydroxylamine on electron-transport system in chloroplasts.


A hydrogen--deuterium exchange study of the conformation of bovine liver glutamate dehydrogenase.


Cyheptamide. A pharmacological evaluation.


Studies on the myocardial depressant effect of KL 255: a beta adrenergic receptor antagonist.


Pig heart triphosphopyridine nucleotide specific isocitrate dehydrogenase. A single polypeptide chain.


Thermolability of proteins of mosquitoes Culex pipiens molestus Forsk.


Quantitative aspects of graft-versus-host reaction in popliteal lymph node.


Torsion of an intra-abdominal testis. A case report.


Paramedical help in Maine practice?

Paramedical help in Maine practice?


Macrophage turnover in inflamed connective tissue.


Personality testing: a new diagnostic aid.


Multivariate analysis in the genetics of spermatozoan dimensions in mice.


Time zone disruption and sleep patterns in pilots.


The Congo experiment.

The Congo experiment.


Oviposition attractants for four species of mosquitoes in natural breeding waters.


Chemistry and pharmacology of a new potential antidepressant. (N-methyl-N-[4-chlorobenzyl-methyl-3-(10,11-dihydro-5H-dibenz(b,f) azepin-5-yl)]-propylamine hydrochloride). (Leo 640, lopraminehydrochloride).


Studies on the antihistaminic effects of thymoquinone, thymohydroquinone and quercetin.


Sympathomimetic drugs and repolarization of ventricular myocardium of the dog.


Co-induction of the hepatic amino acid transport system and tyrosine aminotransferase by theophylline, glucagon and dibutyryl-cyclic AMP in vivo.


Systematic desensitization of social anxiety in the treatment of alcoholism: a psychometric evaluation of change.


Immunological treatment of leukaemias.

Immunological treatment of leukaemias.


On the role of serotonin and acetylcholine in sea urchin morphogenesis.


The transplantation immunology of certain mammalian mothers and progeny.


A theory for cerebral neocortex.

A theory for cerebral neocortex.


Horse haemoglobin polymorphism: evidence for two linked non-allelic alpha-chain genes.


Inhibition of norepinephrine uptake and adrenergic antagonism by N-methyl-N-benzylphenylethanolamine and N,N-dibenzylphenylethanolamine.


Comparison of the pharmacological properties of deptropine, its methobromide--BS 7020a--and the 10,11-dehydro analogues.


Effect of adrenergic drugs on the hemodynamics of the isolated perfused rat liver.


Studies on the mechanism of estrogen biosynthesis. 3. The stereochemistry of aromatization of C19 and C18 steroids.


Purification and partial characterization of glucose 6-phosphate dehydrogenase from cow adrenal cortex.


The metabolism of bile acids in the developing rat liver.


Inactivation of guanosine 5'-phosphate reductase by 6-chloro-, 6-mercapto-, and 2-amino-6-mercapto-9-beta-D-ribofuranosylpurine 5'-phosphates.


Immunological aspects of reticulum cell neoplasia.


Clinical pharmacology. Sympathetic amines.


On the mechanism of potentiation of the activity of acetylcholinesterase by some quaternary ammonium compounds.


The subcellular distribution of (plus or minus)-2,3-dehydroemetine and (-)-emetine in rat liver and changes in hepatic lipid content after treatment of rats with (plus or minus)-2,3-dehydroemetine.


Inhibition by chlorpromazine of the effects of dopamine on the dog kidney.


The effect of a range of Triton non-ionic surfactants on rodent ovaries.


The inhibition of the development of the spores of a spoilage mould by chemical preservatives.


Anti-inflammatory properties of a series of phenyl- and phenoxy-alkanoic acids.


The preparation and intravenous anaesthetic activity of tetrahydrofuran-3-ols.


The distribution of chloroquine in man after fatal poisoning.


The accumulation and metabolism of dopamine by the human platelet.


Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.


On the local anaesthetic action of chlorpromazine and some non-tranquillizing analogues.


Effect of SKF 525A on the fate of thiopentone.


2-mercaptobenzothiazole, an inhibitor of dopamine beta-hydroxylase.


The inhibition of catecholamine biosynthesis by apomorphine.


Inhibition of hepatic ribonuclease activity by chronic administration of phenobarbitone.


Pentazocine and nikethamide antagonism.

Pentazocine and nikethamide antagonism.


Sensitivity changes to noradrenaline in the guinea-pig vas deferens induced by amphetamine, cocaine and denervation.


The time course of the carrageenan-induced oedema of the paw of the rat.


Absorption of (-)-nicotine-l-N-oxide in man and its reduction in the gastrointestinal tract.


A neutron diffraction study of an acetylcholine analogue-erythro(plus or minus)-alpha,beta-dimethylacetylcholine iodide.


Accumulation of 5-hydroxytryptophan in mouse brain after decarboxylase inhibition.


Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slices.


The quantitative analysis of alkyl polyoxyethylene glycol monoethers with mass spectrometry and proton magnetic resonance spectroscopy in combination.


Effects of some phenothiazines, tricyclic antidepressants and antihistamines on red cell agglutination.


Effect of some antiparkinsonian drugs on catecholamine neurons.


Corticosteroid-collagen interaction in vitro: fibril formation from collagen solutions.


Theoretical changes in drug distribution resulting from changes in binding to plasma proteins and to tissues.


The effect of the anion on the absorption of tetracycline from the rat stomach.


The effects of drugs on barbiturate withdrawal convulsions in the rat.


The effect of magnesium ions and Tris buffer on the uptake of cetyl trimethyl ammonium bromide by Escherichia coli.


Thermodynamics of micellization of some non-ionic surfactants in mixed solvents.


The frog as a subject for screening thymoleptic drugs.


A new dry extract of cascara (Rhamnus purshiana D.C. bark).


Molecular complexation of morphine and indol-3-yl sulphuric acid in the dog.


Effect of a progestogen and an oestrogen on the gamma-aminobutyric acid content in the cerebral hemispheres of ovariectomized rats.


Effects of the marihuana-homologue, pyrahexyl, on open field behaviour in the rat.


Cortical stimulation in rabbits by fenfluramine is probably due to an unusual metabolite.


Adrenergic neuron blocking action of dehydroemetine.


Modified technique for recording perfusion rats.


Faecal excretion of degraded and native carrageenan by the young rat.


Effects of desipramine and cocaine on sympathetic responses in the pithed rat.


Correlation of urinary histamine excretion and 24h urine volumes in rats and man.


Macrocationic enzyme inhibition: pepsin and two polylysines.


The demonstration of a tyramine-like substance in a heart extract (Recosen).


The isolation and identification of (-)-apparicine from Tabernamontana cumminsii.


Induction of hepatic drug metabolism in rats by methylchloroform inhalation.


Inotropic actions of dipolar aprotic solvents.


The metabolism and distribution of the selective adrenergic beta blocking agent, practolol.


Negative and positive inotropic responses of the blood-perfused canine papillary muscle to acetylcholine.


Licensure of assistants--a differing view.


The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.


Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide.


The incidence in purebred dogs in Australia of abnormalities that may be inherited.


Sensory deprivation versus sensory variation.