An inhibitory action of histamine on the guinea-pig ileum. 1. In atropinized, plexus-containing preparations of the longitudinal muscle from the guinea-pig ileum, in which histamine contractions were abolished by mepyramine or diphenhydramine, an inhibitory action of histamine was revealed on the "tetanic spasms" produced by field stimulation.2. The inhibitory action of histamine on the atropine-resistant tetanic spasms, which are due to the excitation of non-cholinergic neurones in Auerbach's plexus (Ambache & Freeman, 1968a, b), was reversible. It is specific for the tetanic spasms, because histamine did not reduce contractions elicited by bradykinin, 5-hydroxytryptamine, prostaglandin E(2), nicotine or dimethylphenylpiperazinium.3. L-Histidinol and 2-mercaptohistamine exerted a considerably weaker inhibitory effect upon the tetanic spasms than histamine. Four other imidazoles tested, L-histidine, murexine, dihydromurexine and imidazolecarboxylcholine, were ineffective; so was the pyrazole ring isomer of histamine, betazole.4. The inhibitory action of histamine persisted after adrenoceptor blockade by phentolamine and pronethalol and after prior reserpinization of the guineapigs.5. The inhibitory action of histamine was also obtained after ganglionic paralysis by hexamethonium or dimethylphenylpiperazinium but was antagonized specifically by nicotine.6. On atropinized preparations of the longitudinal muscle from the guinea-pig descending colon histamine exerted, at most, an insignificant inhibitory effect on the tetanic spasms.


Actions of some sympathomimetic bronchodilator and beta-adrenoceptor blocking drugs on contractions of the cat soleus muscle. 1. (-)-Isoprenaline, salbutamol, orciprenaline and quinterenol injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anaesthetized cat.2. Under the most sensitive conditions, the smallest effective dose of (-)-isoprenaline was of the order of 0.01 mug/kg intravenously. Salbutamol was usually 6-10 times, orciprenaline 20-30 times and quinterenol about 35 times less potent than isoprenaline. The effects of salbutamol were about 1.6 times, of orciprenaline about 1.8 times and of quinterenol more than 20 times as long lasting as those of (-)-isoprenaline.3. The effects of the sympathomimetic amines were blocked by propranolol, H56/28, H35/25 and butoxamine but not by ICI 50172. The combined results with agonists and antagonists indicate that the receptors involved can be classified as of the beta(2) type.4. The effect of the amines on the cat soleus muscle appears to be analogous to that causing enhancement of physiological tremor in man, which suggests that skeletal muscle tremor may be an occasional unwanted side effect of the use of these bronchodilators.


The solubility of dodecane in water-amide mixtures.


Kinetics of buccal absorption of some carboxylic acids and the correlation of the rate constants and n-heptane: aqueous phase partition coefficients.


Some physico-chemical properties of SKF 525-A in aqueous solution.


Further structure-activity relations of heterocyclic analogues of hemicholinium-3.


Some pharmacodynamic effects of the nematocides: methyridine, tetramisole and pyrantel.


Potentiation of the effects of noradrenaline and of sympathetic stimulation of the perfused rat caudal artery by angiotensin.


The effects of P-2-AM on the release of acetylcholine from the isolated diaphragm of the rat.


Effects of salicylate on the incorporation of orotic acid into nucleic acids of mouse tissues in vivo.


A new preparation of the isolated intact trachea of the guinea-pig.


Differential inhibition of RNA polymerase activities by salicylate in vitro.


The effect of pH on the bactericidal activity of pentafluorophenol.


The effect of oxotremorine on the acetylcholine content of different parts of cat brain.


A comparison of the beta-adrenoreceptor stimulant properties of isoprenaline, with those of orciprenaline, salbutamol, soterenol and trimetoquinol on isolated atria and trachea of the guinea pig.


The absence of a significant histamine receptor reserve in vascular smooth muscle.


The formation of 5-hydroxytryptophol from exogenous 5-hydroxytryptamine in cat spinal cord in vivo.


Inhibition of gastric acid secretion by a potent synthetic prostaglandin.


Inhibition of neuromuscular transmission in the intact rat by emetine.


Interactions between calcium and some mylotic agents on depolarized vascular smooth muscle.


Treatment of experimental lymphoedema with coumarin.


Induction of hepatic tyrosine aminotransferase mediated by a cholinergic agent.


Cerebral acidosis following increased intracranial pressure.


Polyarteritis nodosa of the gallbladder.


The occurrence of two new prostaglandin derivatives (15-epi-PGA2 and its acetate, methyl ester) in the gorgonian Plexaura homomalla chemistry of coelenterates. XV.


The identification and control of metabolic states.


Extreme lability of the C-8 proton: a consequence of 7-methylation of guanine residues in model compounds and in DNA and its analytical application.


The therapeutic effect of atropine and tetraethylammonium bromide against anticholinesterase insecticides in mice and rats.


Aromatization of epitestosterone by human placenta.


Genetic aspects of adrenal and hepatic cortisol 2alpha- and 6beta-hydroxylation in guinea pigs: Developmental pattern and effect of substrate concentration.


Some morphological and biochemical characteristics of isolated rat liver cells dissociated with sodium tetraphenylboron and cultured in suspension.


Electronmicroscopic observations on the Sertoli cell in the experimentally cryptorchid rat testis.


Carbon dioxide reduction with alkali-metal amalgams. AMRL-TR-68-36.


Incidence of dental caries and periodontal disease in Down's syndrome.


Unstimulated human parotid fluid: specific gravity and osmolality. SAM-TR-69-37.


Requirements study for a biotechnology laboratory for manned earth orbiting missions. I. Results, recommendations and requirements. NASA CR-1408.


Solid electrolyte system for oxygen regeneration. NASA CR-1359.


Study of the astronaut's capabilities to maintain life support systems and cabin habitability in weightless conditions. NASA CR-1405.


Biochemical and metabolic effects of a six-month exposure of small animals to a helium-oxygen atmosphere. NASA CR-1372.


Requirements study for a biotechnology laboratory for manned earth orbiting missions. II. Summary of individual ezperiments requirements. NASA CR-1409.


Toward a psychodynamic theory of alcoholism.


Polypharmacy in psychiatric treatment. I. Incidence at a state hospital.


Regional distribution and metabolism of H3-tyramine in the rat brain.


Pharmacology of barium nitrosylpentacyanoferrate.


The effect of paragone on the human bladder.


The therapeutic value of cinnarizine in cervico-brachial and ischial syndromes.


Respiratory depression: narcotic versus narcotic-tranquilizer combinations.


Evaluation of preoperative and postoperative sedation with propiomazine with or without meperidine in geriatrics.


Anesthesia for the fractured hip: a survey of 200 cases.


Dissociation between biochemical and ultrastructural effects of 6-hydroxydopamine in rat brain.


Lack of specific inhibition of graft-versus-host reaction by anti-Fab serum.


Competent Diplococcus pneumoniae accept both single- and double-stranded deoxyribonucleic acid. The transforming activity of fractionated complementary strands of Diplococcus pneumoniae deoxyribonucleic acid (DNA) bands at the position of fully denatured DNA in CsCl at pH 11.0, and is completely (> 99.8%) destroyed by digestion with exonuclease-I. These results prove that pure single strands transform the normally prepared competent cells of this species. Their efficiency is about 0.5% that of native DNA of comparable size.


Mutants of Diplococcus pneumoniae that lack deoxyribonucleases and other activities possibly pertinent to genetic transformation. Mutants of Diplococcus pneumoniae that lacked the two major deoxyribonucleases of the cell-one an endonuclease, the other an exonuclease preferentially active on native deoxyribonucleic acid (DNA)-were obtained. The development of a method for detecting mutant colonies, based on the binding of methyl green to DNA, facilitated isolation of the mutants. Neither enzyme was essential for growth of the cells, for repair of ultraviolet damage, or for any phase of DNA-mediated transformation. Residual deoxyribonuclease activity in the double mutant corresponded to an exonuclease, approximately one-fifth as active as the major exonuclease, that attacked native and denatured DNA equally well. This activity appeared to be associated with the DNA-polymerase enzyme. A mutant that apparently lacked a cell wall lytic enzyme was also fully transformable. A mutant strain that was four times more sensitive to ultraviolet light than the wild type also transformed normally. Recipient cells of this strain were deficient in the repair of ultraviolet-irradiated transforming DNA. Mutants were found which, unlike the wild type, integrated donor markers only with high efficiency, thereby indicating that a particular cellular component that is susceptible to loss by mutation, such as an enzyme, is responsible for low integration efficiency.


The timing of the asexual cycles of Plasmodium lophurae and of P. cathemerium.


Human cardiovascular effects of alprenolol, a beta-adrenergic blocker: hemodynamic, antiarrhythmic, and antianginal.


The nature and extent of psychotropic drug usage in the United States.


Electron-nuclear double resonance from flavin radicals in liquid and polycrystalline phase and conjugated to protein.


Effects of thyrotropin in vivo on dog-thyroid pyridine nucleotides.


Adrenocorticotropin-induced generation of 5'-phosphoribosylpyrophosphate and its relation to nucleotide synthesis in the adrenal cortex.


First International Congress of Dento Maxillofacial Radiology.


Studies on march haemoglobinuria.

Studies on march haemoglobinuria.


An insurance adjuster views a dental claim.


Results of eleven years of fluoridation in Fayette, Alabama.


An evaluation of the utility of application and cariostatic effectiveness of phosphate-fluorides in solution and gel states.


Cogan's syndrome.

Cogan's syndrome.


Alcoholism.

Alcoholism.


Modulator theory of adrenergic receptor mechanism: vessels of the dog hindlimb.


A filtration method for the separation of cell sap from the large-particle fraction of rat liver suspensions, enabling the rapid measurement of nucleotide distributions. A simple method is described that allows a rapid separation of a cell-sap fraction from the large-particle fraction of rat liver suspensions. The method is based on the filtration under suction of liver suspensions through Millipore filters that retain nuclei, mitochondria and some of the endoplasmic-reticulum fraction, but allow quantitative passage of cell sap into a collecting tube. The cell sap may be separated in this manner within 2min of the death of the rat. The method was applied to study the intracellular distribution of ATP and of the nicotinamide-adenine dinucleotides and the results obtained were compared with those obtained after separating the cell sap by a rapid centrifuging procedure. The percentage of total liver ATP in the cell sap was found to be 46% by the filtration method and more than 70% by the centrifuging procedure. Corresponding figures found for the distribution of NADP(+)+NADPH were 40 and 49% respectively.


The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog.


Effect of whole and fractionated cobra venom on sympathetic ganglionic transmission.


Regulation of the biosynthesis of amino acids of the aspartate family in Coliform bacteria and Pseudomonads. The control of aspartokinase and homoserine dehydrogenase activities was compared in aerobic and fermentative pseudomonads (genera Pseudomonas and Aeromonas), and in coliform bacteria representative of the principal genera of the Enterobacteriaceae. Isofunctional aspartokinases subject to independent end-product control occur in the Enterobacteriaceae and in Aeromonas. In Pseudomonas, there appears to be a single aspartokinase, subject to concerted feedback inhibition by lysine and threonine. Within this genus, the sensitivity of aspartokinase to the single allosteric inhibitors varies considerably: the aspartokinase of the acidovorans group is little affected by the single inhibitors, whereas that of the fluorescent group is severely inhibited by either amino acid at high concentration. In all bacteria examined, homoserine dehydrogenase activity is inhibited by threonine; inhibition is more severe in aerobic pseudomonads than in the other groups. In most of the bacteria examined, either nicotinamide adenine dinucleotide (NAD) or nicotinamide adenine dinucleotide phosphate can serve as a cofactor for this enzyme, though the relative activity with the two pyridine nucleotides varies widely. Aerobic pseudomonads of the acidovorans group contain a homoserine dehydrogenase that is absolutely specific for NAD. The taxonomic implications of these findings are discussed.


Influence of feeding habits and adrenal cortex on diurnal rhythm of hepatic tyrosine transaminase activity.


Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation.


Daily variation in liver tryptophan, tryptophan pyrrolase, and tyrosine transaminase in rats fed ad libitum or single daily meals.


Alpha-chloromethyl-2-methyl-5-nitro-1-imidazoleethanol (Ro 7-0207), a substance exhibiting antiparasitic activity against amebae, trichomonads, and pinworms.


Effect of diet and insulin on the morphology and TPNH generating enzyme activities of rat adipose tissue.


Suppression of the graft-versus-host reaction by passive immunization of donor against recipient antigens.


The effects of anesthesia and pulmonary ventilation on blood loss during elective therapeutic abortion.


Alteration of microsomal biotransformation in the liver in cholestasis.


Hemolysis due to inherited erythrocyte enzyme deficiencies.


Effects of drugs and drug metabolites on erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient individuals.


In vitro activity of coumermycin A1.

In vitro activity of coumermycin A1. The in vitro activity of coumermycin A(1) was compared with that of novobiocin, ampicillin, and minocycline. Coumermycin was found to be the most active antibiotic of the four against Staphylococcus aureus. It was about 50 times more active than novobiocin or minocycline against the strains tested. Coumermycin also showed good activity against group A streptococci and pneumococci, moderate activity against Escherichia coli, indole-positive Proteus species, and Pseudomonas aeruginosa, and poor activity against Klebsiella-Enterobacter and enterococci. Against P. mirabilis, however, coumermycin activity was almost equal to that of ampicillin. The new antibiotic was further found to be greatly reduced in activity in the presence of plasma, but its minimal inhibitory concentration was not greatly affected by inoculum size. Coumermycin was found to be bacteriostatic in its action, and resistance to it developed slowly. Also, cross-resistance was present with novobiocin but absent with ampicillin or minocycline.


Thermal death of Bacillus subtilis var. niger spores on selected lander capsule surfaces. Dry-heat sterilization of planetary lander capsules requires a knowledge of the thermal resistivity of microorganisms in the environment to which they will be subjected during sterilization of the space hardware. The dry-heat resistance of Bacillus subtilis var. niger spores on various lander capsule materials was determined at 125 C. Eight surface materials were evaluated, including a reference material, stainless steel. Survivor curves were computed, and decimal reduction times (D values) were obtained by a linear regression analysis. In four tests on stainless steel, the average value of D at 125 C was 17.07 min. The D values for the other seven materials tested ranged from 18.64 min on magnesium surfaces to 20.83 min on conversion-coated magnesium. Of the materials evaluated, the results indicate that there is only a significant difference in the thermal resistance of B. subtilis var. niger spores on conversion-coated magnesium and conversion-coated aluminum from that on the reference material, stainless steel. The differences in D values for all the test surfaces may be the result of variations in test procedures rather than the effect of the surfaces on the thermal resistivity of the spores.


The composition of phospholipids in outer and inner mitochondrial membranes from guinea-pig liver.


AMA 23rd National Conference on Rural Health.


A microtiter plate technique for the agglutination typing of Diplococcus pneumoniae.


Alpha-adrenergic blocking action of norephedrinetheophylline (NET) observed in the renal vascular response.


Detoxication of ammonia in sheep fed soy protein or urea.


Effect of compounds affecting the adrenergic mechanism on cell growth and division of Tetrahymena pyriformis W.


Formation of assimilatory nitrate reductase by in vitro inter-cistronic complementation in Neurospora crassa. In vitro complementation of the soluble assimilatory nicotinamide adenine dinucleotide phosphate, reduced form (NADPH)-nitrate reductase was attained by mixing cell-free preparations of certain Neurospora nitrate reductase mutants: induced nit-1 (uniquely possessing inducible NADPH-cytochrome c reductase) with (a) uninduced or induced nit-2 or nit-3, or (b) uninduced wild type. The complementing activity of induced nit-1 is soluble while that of nit-2, nit-3, and wild type is particulate but not of mitochondrial origin. All fractions are inactivated by heat or trypsin. The NADPH-nitrate reductase enzymes formed in the above three complementing mixtures are similar to the wild-type enzyme in sucrose density gradient profiles, molecular weight, substrate affinity, sensitivity to inhibitors and temperature, but show different ratios of associated enzyme activities. The data suggest that nitrate reductase consists of at least two protein subunits: a nitrate-inductible subunit as reflected by inductible NADPH-cytochrome c reductase, and a constitutive protein which is activated (as indicated by the appearance of flavine adenine dinucleotide, reduced form (FADH(2))- and reduced methyl viologen-nitrate reductase activities) when it combines with the inductible subunit.


Engineering criteria for spacecraft cabin atmosphere selection. NASA CR-891.


On the significance of inhibiting haptens.


Poisoning in childhood.

Poisoning in childhood.


Effect of different beta-adrenergic receptor blocking agents on hexobarbital induced narcosis in mice.


Aminotransferases in cases of gastric ulcers. I. "Aminotransferase pattern" of a native homogenate and subcellular fractions of the human gastric mucous membrane.


Levels of personal conflict derived from response to the emotion profile index.


A comparison of male and female patients at an alcoholism treatment center.


Growth potential of radish in a controlled environment. SAM-TR-69-72.


Radionuclide concentrations in Columbia river estuarine organisms. BNWL-1051.


Inguinal hernia, hydrocele, and other genitourinary abnormalities in boys with cystic fibrosis and their male siblings.


Simultaneous mixed bacterial meningitis in an infant caused by Diplococcus pneumoniae and Herellea vaginicola.


Computer derived global judgments in psychiatry.


Complications of smallpox vaccination: surveillance during an island-wide program in Puerto Rico, 1967-1968.


Developments in non-anticholinergic anti-ulcer agents.


Children's oral problems in Costa Rica and programs leading to their solution.


The chemistry of carbohydrazide and thiocarbohydrazide.


Histologic observations in crytorchidism: the congenital germinal-cell deficiency of the undescended testis.


Use of anti-arrhythmic agents other than digitalis.


Light and electron microscopic examinations of undescended testicles.


Bicycle spoke injuries of the foot and ankle in children: an underestimated "minor" injury.


Rare bases in animal DNA.

Rare bases in animal DNA.


The electrophysiological study of the responses of the isolated labyrinth of the lamprey (Lampetra fluviatilis) to angular acceleration, tilting and mechanical vibration.


The permeability of arterial endothelium to horseradish peroxidase.


The noradrenaline content of the vas deferens of the guinea-pig.


Perfusion of rat's liver with blood: transmitter overflows and gluconeogenesis.


Excitatory and depressant effects of beta-adrenoceptor blocking agents on skeletal muscle.


Quantitative aspects of vibration-induced mortality.


Influence of guanethidine on contractions of isolated seminal vesicles of the rat.


Adrenergic mechanisms in the initiation of cardiac arrhythmias.


Lymphocyte as a myeloid cell precursor.

Lymphocyte as a myeloid cell precursor.


A new antihistamine in the treatment of allercig disease.


Effect of thyroxin on heparin inhibition of cortisone A-ring reduction.


2 new groups of selective stimulants of adrenergic beta-receptors.


Spontaneous transmitter release from motor nerve endings in muscle fibres of castrated and old animals.


Reversion of alpha- into beta-hemolysis of Diplococcus pneumoniae by low concentration of optochin.


Preparation of biologically active mono-N-acetyl (14C)-derivatives of the membrane-specific polypeptide antibiotic polymyxin B.


A study of the association of prodigiosin, isolated from Serratia marcescens.


Potential transducing properties of microelectrodes filled with electrolyte or metal.


Some heterocyclic nitrogenous compounds as radioprotectants for hematological levels in x-irradiated mice.


On the molecular mechanism of the proton pump in photosynthesis.


CNS at the cellular level: identity of transmitter agents.


Heart.

Heart.


Respiration.

Respiration.


Patency changes in dog's Eustachian tube in response to alpha and beta adrenergic drugs.


Utilization of dicarboxylic acids by Pseudomonas aeruginosa.


Shivering and nonshivering thermogenesis in the bat (Myotis myotis Borkh.) during arousal from hibernation.


The efficacy of antiarrhythmic drugs in the prevention of recurrence of aconitine-induced atrial fibrillation after electrical conversion.


Changes in schizophrenic intelligence under thioproperazine therapy.


A male pseudohermaphrodite dog with a Sertoli's cell tumor, mucometra, and vaginal glands.


The fine structural organization of the sea nettle fishing tentacle.


Effect of gonadotropin in cryptorchism.

Effect of gonadotropin in cryptorchism.


Wilms tumor demonstrating onset and rapid growth.


Some preliminary observations on a psychiatric inpatient merchant seamen population using the MMPI.


Memoir of Sir Henry Hallett Dale 1875-1968.


Hyperbaric oxygenation as a therapeutic method in experimental subacute and chronic peripheral circulatory disturbances.


Modification of adrenaline action at the neuromuscular junctiin by bivalent metals and adrenergic receptor blocking agents.


Necrotizing granuloma of the midline tissues following renal transplantation.


Demonstration of adrenergic receptor function and innervation in the ductus arteriosus of the human fetus.


The effect of gastric juice extracts on histamine as a gastric secretory stimulant.


Studies on the relaxing actions mediated by stimulation of adrenergic alpha- and beta-receptors in taenia coli of the rabbit and guinea pig.


Nutrition in the Kuru region. I. Gardening, food handling, and diet of the Fore people.


Nutrition in the Kuru region. II. A nutritional evaluation of traditional Fore diet in Moke village in 1957.


Studies on the site of development of slow loris (Nycticebus coucang) filaria in mosquitoes.


Purification, stabilization, and properties of bovine mammary UDP-galactose 4-epimerase.


High frequency nuclear magnetic resonance study of the M and P helices of reduced pyridine dinucleotides.


Intracellular localization of enzymes in yeast.


High frequency nuclear magnetic resonance investigation of the backbone of oxidized and reduced pyridine nucleotides.


Investigation of the configuration and conformation of N-methyl-N-ethylnicotinamide-adenine dinucleotide by nuclear magnetic resonance spectroscopy.


Plasma kinin activity in cirrhotic subjects.


Glucose dehydrogenase activity of yeast glucose 6-phosphate dehydrogenase. Inhibition by adenosine 5'-triphosphate and other nucleoside 5'-triphosphates and diphosphates.


Preference intransitivity as an indicator of cognitive slippage in schizophrenia.


Verbal conditioning of psychopaths as a function of experimenter-subject sex differences.


Catabolite-controlled regulation of glutamate dehydrogenases of Neurospora crassa.


On discussing papers.

On discussing papers.


Effect of alpha-adrenergic blockade on insulin secretion in man.


Oxidation of reduced nicotinamide-adenine dinucleotide in Rhodospirillum rubrum. 3. Properties of a NADH dehydrogenase solubilized from electron transport particles.


The kinetics of changes in the redox state of ubiquinone on the transition from state 4 to state 3 in rat-liver mitochondria.


Properties of partially purified photosynthetic reaction centers from Scenedesmus mutant 6E and Anabaena variabilis grown in the presence of diphenylamine.


Comparison studies on the effects of ultraviolet irradiation on photosynthesis.


Properties of Anabaena variabilis cells grown in the presence of diphenylamine.


Preparation and physicochemical properties of functional hemoprotein P450 from mammalian tissue microsomes.


Adrenergic beta-blockade with ICI 50,172 (practolol, "Eraldin") during bronchoscopy.


The effect of beta-blockade in the relationship between cardiac output and carbon dioxide.


Mechanism of perpetuation of animal viruses in nature.


Actuarial versus clinical prediction in psychopathology.


Psychophysiologic changes accompanying oral contraceptive use.


Experimental treatment of necrosis produced by proteolytic snake venoms. 3. Action of a combination of antihistaminic, adrenalin, and hydrocortisone (AAC).


Dental health education in operation, the Irish example.


Back pain, renal failure, and abnormal infusion pyelogram.


Maine Heart Association notes.

Maine Heart Association notes.


Hypertension and abdominal pain after resection of aortic coarctation.


Polyarteritis presenting with leg pains.


A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers.


Polymyalgia rheumatica.

Polymyalgia rheumatica.


The international union against cancer.

The international union against cancer.


Trial of two beta blockade drugs, Ciba 39089 and ICI 50172, in angina pectoris.


The adrenergic receptors.

The adrenergic receptors.


Clinical and experimental experience with 39089 BA (trasicor) as an anti-arrhythmic agent.


Repeated and continuous exposures of laboratory animals to trichlorofluoromethane.


Positive antihuman globulin test in patients receiving carbromal.


Effect of beta-adrenergic receptor blockade on coronary haemodynamics in the resting unanaesthetized dog.


The possible role of measles virus in the pathogenesis of multiple sclerosis.


The effect of live attenuated measles-virus vaccine on the central nervous system.


Kinetic behavior of D-amino acid oxidase in its reaction with basic amino acids.


Report on congress on medical education.


The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.


Autonomic hyper-reflexia--suppression with alpha-adrenergic blocking agents.


Health of the campus community.

Health of the campus community.


Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system.


Fatty acid synthesis in rat liver: relative contributions of the mitochondrial, microsomal and non-particulate systems.


Effects of antihypertensive drugs in the spontaneously hypertensive rat.


Hydroxylation of oleic acid by cell-free extracts of a species of torulopsis.


The double contrast examination of the small intestine. Preliminary communication of a new technique.


Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction.


Effect of the adrenergic neurone blocker, beta-TM10, on the depletion of noradrenaline induced by denervation or reserpine.


Reduction of urinary precipitates through manipulation of diet in Macaca nemestrina.


Consumption of rehydratable food in zero-gravity environments using conventional eating utensils.


Effect of 4,4-dideuteration of reduced nicotinamide-adenine dinucleotide phosphate on the mixed function oxidases of hepatic microsomes.


Corticosteroid metabolism and liver glycogen in fetal and newborn mice.


Cytochemical demonstration of 'marker' enzymes in nerve cells cultured in vitro.


Comparison of mitochondrial with microsomal acylation of monoacyl phosphoglycerides.


Double infection in a mosquito Armigeres subalbatus (Coquillett) (A. obturbans auct.) with two different species of filaria.


2,5-dimethoxy-4-methylamphetamine: clinical evaluation of a new hallucinogenic drug.


Personality differences in the response to stimulant drugs administered during a sleep-deprived state.


Water quality and pollution.

Water quality and pollution.


Resistance of pig tonsillary and throat mucosa to reinfection with a homologous pseudorabies virus strain.


Some properties of interferon released by mouse peritoneal leukocytes stimulated with endotoxin, mannan and Newcastle disease virus in vitro.


Preparation of concentrated intracellular precipitating antigens of varicella-zoster and herpes simplex viruses and results obtained with them in the gel precipitation reaction.


Experimental infection of horses with A-equi 2-Miami-1-63 and human A2-Hong Kong-1-68 influenza viruses. 3. Immunodiffusion study of the antibody response.


Immunofluorescence detection of lymphocytic choriomeningitis virus in guinea pig blood leukocytes.


Quantitative study of tick-borne encephalitis virus in Ixodes ricinus ticks.


Experimental infection of monkeys with Kemerovo virus.


Pathogenicity of Uukuniemi virus for white mice.


The effect of subsequent passage on the activation of densonucleosis virus in Galleria mellonella L.


Complementation of Coxiella burneti in mixed infection of heat-inactivated "phase" II and host-dependent "phase" I organisms in L cells.


Effect of trypaflavine on host-cell reactivation of some Bacillus subtilis phages irradiated with UV light.


Relationship between strains of Crimean haemorrhagic fever and Congo viruses.


The difference in thermostability of haemagglutinin and neuraminidase of two variants of influenza A2 virus.


Influence of medium from aged uninfected chick embryo cell cultures on interferon formation induced by tick-borne encephalitis virus.


Formation of antibody to tick-borne encephalitis virus in Lacerta viridis and L. agilis lizards.


Studies on Tick-borne encephalitis virus. II. Virus morphology and some data on virus structure.


In vitro action of carbenicillin against bacteria isolated from clinical material. More than 500 bacteria isolated from patient material were tested against carbenicillin (disodium alpha-carboxybenzylpenicillin) by diffusion and dilution modalities. The same bacteria, which included Pseudomonas aeruginosa, Escherichia coli, Klebsiella-Aerobacter-Enterobacter group, various species of Proteus, Staphylococcus aureus and epiddermidis, enterococci, pneumococci, Streptococcus pyogenes, etc., were examined for susceptibility to other antibiotics commonly used with special emphasis on ampicillin and cephalothin. The responses of pyocine-typed P. aeruginosa were the most remarkable. The majority of these bacteria displayed susceptibility to carbenicillin by both the dilution and the diffusion techniques. The concentrations of this antibiotic used in the laboratory were of the same order of magnitude as that of the other drugs. The laboratory behavior of the other bacteria, toward this new semisynthetic penicillin derivative approximated their response to ampicillin and cephalothin.


The influence of the periarterial nerve fibres on an isolated and perfused small mesenteric artery.


Investigation of a possible beta-blocking action of prenylamine in man.


Purification and properties of uronate dehydrogenase from Pseudomonas syringae.


Time and cost factors to provide regular, periodic dental care for children in a fluoridated and nonfluoridated area: final report.


Controlled fluoridation: the dental effects of discontinuation in Antigo, Wisconsin.


Iatrogenic cardiovascular disease (an aspect of preventive cardiology).


Albany topical fluoride study.

Albany topical fluoride study.


An attempt to identify prisoners with an XYY chromosome complement by psychiatric and psychological means.


Degree of splenomegaly in domestic chickens selected for resistance and susceptibility to Marek's disease.


A comparison of the cardiovascular actions of AQ 110 with those of isoprenaline and salbutamol. 1. AQ 110 is a beta-adrenoceptor agonist which, like isoprenaline and salbutamol, acts directly on the receptors.2. Compared with isoprenaline, AQ 110 has relatively stronger actions on bronchial and vascular smooth muscle (beta(2)-adrenoceptors) than stimulant effects on heart muscle (beta(1)-adrenoceptors). The beta(2)-selectivity of AQ 110 is, however, much less than that of salbutamol, mainly due to the weak cardiac actions of the latter.3. At doses which were equipotent in decreasing the bronchoconstrictor effect produced by a standard dose of 5-hydroxytryptamine, AQ 110 had marginally less hypotensive action than salbutamol and considerably less than isoprenaline.4. Although AQ 110, unlike salbutamol, possesses a catechol group it was found not to be a substrate for catechol-O-methyl transferase and this is considered to account for its significantly prolonged action, compared with isoprenaline, in vivo.


The action of beta-receptor antagonists on intracellular cardiac potentials.


Drug-induced pilomotion: as easily demonstrated alpha-effect of sympathomimetic drugs.


Inhibition of rabbit intestine mediated by alpha- and beta-adrenoceptors. 1. The effects of some alpha- and beta-adrenoceptor agonists and antagonists were studied on isolated segments of rabbit intestine in an attempt to characterize the two types of inhibitory response produced by sympathomimetic amines.2. Phenylephrine, an alpha-adrenoceptor agonist, produced an inhibition of rapid onset, from which recovery occurred despite the continued presence of the drug. On washout there was an overshoot in contraction height. Isoprenaline, a beta-adrenoceptor agonist, produced an inhibition of slow onset which was maintained throughout the presence of the drug and there was no overshoot on washout.3. Adrenaline resembled phenylephrine more closely than it resembled isoprenaline, in that it showed more affinity for alpha-adrenoceptors, whereas noradrenaline, and the transmitter released on periarterial nerve stimulation, behaved more like isoprenaline, although both types of receptor were affected.4. Adenosine-5'-triphosphate produced an inhibition resembling that produced by an alpha-adrenoceptor agonist, whereas the dibutyryl analogue of cyclic adenosine 3',5'-monophosphate (cyclic 3',5'-AMP) produced an inhibition resembling that produced by a beta-adrenoceptor agonist.5. In critical concentrations theophylline augmented and imidazole inhibited beta-adrenoceptor mediated responses, as well as responses to dibutyryl cyclic AMP. However, additional actions of theophylline and imidazole were also demonstrated.6. Responses mediated by alpha-adrenoceptors, but not those mediated by beta-adrenoceptors, were blocked by membrane stabilizers, quinidine being the most potent of those studied.7. The results are discussed in relation to the possible mechanisms of action of alpha- and beta-adrenoceptor agonists.


An improved method of spacecraft sterilization.


Some metabolic aspects of the obese-hyperglycemic syndrome in mice.


Effect of DL- and D-propranolol on oscular tension in rabbits and patients.


The influence of pharmacological blockade of presynaptic and postsynaptic adrenergic structures on electrically induced arrhythmias of the guinea-pig atria.


Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.


Effects of metyrapone on liver microsomal drug oxidations.


Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.


Haemodynamic effects of dextro-propranolol in acute myocardial infarction.


An ultrastructural examination of the mesoglea of Hydra.


Need for dental care among adults.

Need for dental care among adults.


The kinetics of DNA methylation in cultures of a mouse adrenal cell line.


The chemistry of some toxins isolated from marine organisms.


Personality, defensiveness and educational achievement. II. The Cattell 16PF questionnaire.


Subject anonymity and motivational distortion in self-report data.


MMPI correlates of ulcerative colitis.

MMPI correlates of ulcerative colitis.


MMPI scores and marital status in male schizophrenics.


A note on the role of facilitative responsibility in the therapeutic relationship.


Mevalonate biosynthesis in rat liver.

Mevalonate biosynthesis in rat liver.


Current status of marine biomedicinals.

Current status of marine biomedicinals.


Effects of chlorpromazine on glutamate dehydrogenase.


Effects on smooth muscle preparations of unidentified vasoactiv peptides from intestine and lung.


Intra-amniotic injection of pyridine nucleotides or adenosine triphosphate as countertherapy for 6-aminonicotinamide (6-AN) teratogenesis.


The human eye as a target to analyse the mechanism of action of substances.


The use of doxapram hydrochloride with intravenous anesthetics in horses. I.


In vitro synthesis of lignoceric and nervonic acids in mammalian liver and brain.


The use of doxapram hydrochloride with inhalation anesthetics in horses. II.


Conformational influences on antihistamine activity. The crystal structure of 2-[(2)-dimethylaminoethyl)-2-thenylamino]pyridine hydrochloride, an antihistamine.


Beta-adrenergic blocking agents. VII. 2-(1,4-benzodioxanyl) and 2-chromanyl analogs of pronethalol (2-isopropylamino-1-(2-naphthyl)ethanol).


Antiprotozoal quinones. 3. Synthesis of 8-amino-5,6-quinolinediones, 8-amino-7-chloro-5,6-quinolinediones, and 8-amino-5,5,7-trichloro-6 (5H)-quinolones as potential antimalarials.


Conversion of carbohydrate to fat in adipose tissue: an energy-yielding and, therefore, self-limiting process. A theoretical analysis of the energy metabolism associated with the conversion of glucose to fat is presented. In tissues where the pentose cycle furnishes some of the NADPH required for fatty acid synthesis, this conversion is an ATP-yielding process. In rat adipose tissue the maximal rate of glucose conversion to fat can be quantatively predicted on the basis of the tissue's ability to use the ATP which is generated in excess during this conversion. The energy-generating nature of this process provides the means for a type of regulation which depends on metabolic state and which, during fasting, contributes to the sparing of carbohydrate. Impairment of lipogenesis in the fasting state is attributed to a decrease in the activity of the malate cycle and to the presence of free fatty acids. However, rather than by inhibiting specific enzymes, it is by virtue of their quality as substrates for energy production that free fatty acids and their CoA derivatives appear to inhibit de novo lipogenesis. The regulatory phenomena discussed here may explain the failure of the attempts made to identify the rate-limiting step for de novo lipogenesis in adipose tissue.


The effects in mice of cortisol combined with thymus antiserum on Sarcoma 180 and antibody responses.


Hyperplasia of the interstitial cells of the testis in experimental cryptorchidism.


Aggressive behavior of rats induced by mesorgydine (Lysenyl Spofa).


The effect of centrophenoxine on EEG vigilance in the course of sleep deprivation and on the EEG pattern of all-night sleep.


Renal transplantation and rejection: a review.


Nuclear electron transport. I. Electron transport enzymes in bovine liver nuclei and nuclear membrane.


Studies on the bioluminescence of Renilla reniformis. VII. Conversion of luciferin into luciferyl sulfate by luciferin sulfokinase.


Oxidation of indan to indanol and indanone by the hepatic microsomal system.


Anomalous mutarotation of glucose 6-phosphate. An example of intramolecular catalysis.


The biosynthesis of thiamine. Conversion of 2-methyl-4-amino-5-formylpyrimidine to 2-methyl-4-amino-5-hydroyxmethylpyrimidine by cell-free extracts of baker's yeast.


Stereochemistry of hydrogen transfer by rat ovary 20 alpha-hydroxysteroid dehydrogenase.


Hydroxymethylation of the benzene ring. V. NADPH requirement for aryl hydroxymethylation by a C-1 donor bound to a macromolecule.


From cultured cells to whole plants: the induction and control of their growth and morphogenesis.


The influence of sympathicolytics of the electrocardiogram.


Male reproductive tract, spermatophores and spermatophoric reaction in the giant octopus of the North Pacific, Octopus dofleini martini.


Spermatozoa of the giant octopus of the North Pacific Octopus dofleini martini.


The accuracy of the patterns of connexions of the first- and second-order neurons of the visual system of Calliphora.


The tiered retina of Dytiscus: a new type of compound eye.


The collagen diseases: Clues as to their etiology.


Quinuclidine chemistry.

Quinuclidine chemistry.


Protection against accidental decompression by compartmentalization of spacecraft and aircraft.


Venous pressure of man in space.

Venous pressure of man in space.


Preliminary investigation of bone change as a result of exposure to reduced atmospheric pressure.


Studies of the effect of beta-adrenergic blockade on abnormal R-ST segment and T-wave changes.


Survival of donor epithelium in experimental corneal xenografts.


Modification of corneal homograft rejection by donor pretreatment with antilymphocyte serum.


New dimensions in legal and ethical concepts for human research. 2. Special problems of medical disciplines. Conditions of use of hazardous substances in clinical research.


Comparative biochemistry of proteases from a coelenterate.


Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver.


Interactions between 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155, Catapresan) and alpha-adrenergic blocking drugs.


The effects of beta-receptor agonists and antagonists on regional blood flow.


Trial of a serotonin inhibitor BC 105 in the prevention of migraine.


The cardiological technician and medical research.


The natural resistance of pigeons to type 3 pneumococcus.


Increased vascular permeability evoked by crush injury in the skin of the rat.


Drug--interaction between sulthiame (Ospolot (R)) and phenytoin in the treatment of epilepsy.


Supraspinal interactions of anesthetic, neuroleptic and analeptic drugs on the fusimotor effects of pinna stimulation in the cat.


Four cases of pedal cryopathy.

Four cases of pedal cryopathy.


A method of coding, recording, and collecting data in a DMF survey.


Yet another look at clinical and statistical prediction: or, is clinical psychology worthwhile?


Occult pneumococcal bacteremia.

Occult pneumococcal bacteremia.


Use of microfluorimetry to study the metabolism of intact cells.


Mild ulcerative colitis.

Mild ulcerative colitis.


Aspects of the determination of biphenyl hydroxylase activity in liver homogenates. I. Effect of the presence of mitochondria.


Our responsibilities.

Our responsibilities.


Clinical cancer chemotherapy aimed at cellular control mechanisms.


Emergency supply of rabies vaccine.

Emergency supply of rabies vaccine.


Future forensic medicine in Illinois.

Future forensic medicine in Illinois.


"Pasteurella multocida".

"Pasteurella multocida".


Experience in suicide prevention. "Calls for help in Chicago".


Congress undermining confidence in doctors, medical society charges.


Morbidity patterns reflected in a school health program during an influenza epidemic season.


Peer review guidelines.

Peer review guidelines.


Response of staphylococcal respiratory infections to dicloxacillin.


The enzymatic defect in essential pentosuria.


Familial endocrine adenomatosis.

Familial endocrine adenomatosis.


Late onset of respiratory insufficiency after poliomyelitis. A preliminary communication.


Polyarteritis nodosa in identical twins.


On the regulation of glycogen metabolism in Tetrahymena.


Purification and properties of wheat germ D-3-phosphoglycerate dehydrogenase.


Respiratory stimulants in treatment of perinatal asphyxia. The effects of two analeptic drugs-taloximine and ethamivan-have been studied in asphyxiated fetal and newborn rabbits. In primary apnoea ethamivan reduced the time before the onset of gasping, while during gasping taloximine increased the gasp rate. In secondary apnoea neither drug initiated respiration, though most animals could be resuscitated by using intermittent positive pressure respiration. From these results it is suggested that analeptic drugs have no place in obstetric or neonatal departments.


Drugs used in vomiting.

Drugs used in vomiting.


An estrogen effect on 20 alpha-hydroxysteroid dehydrogenase activity in the mouse adrenal.


Effects of estradiol on the levels of pyridine nucleotide coenzymes in the rat uterus.


Testosterone-induced hypertension in the rat.


Mono- and indolamines and control of LH secretion.


The activity of oxidative enzymes in short-term explant cultures of gliomas in vitro. II. Coenzyme I and II-bound dehydrogenases and NADPH-diaphorase.


Concentration of estrogens in maternal peripheral plasma in late pregnancy, during labor and post partum.


Strychnine antagonism and glycine: a reply.


Antihypertensive therapy with alprenolol, a beta-adrenergic receptor antagonist.


Effect of aptin, a beta-adrenergic blocking agent, in arterial hypertension.


A dissociable mutant form of diphydrofolate reductase from Diplococcus pneumoniae.


Contractile responses of microvascular smooth muscle to antihistamines.


Factors governing the steady state of the mitochondrial nicotinamide nucleotide transhydrogenase system.


The activities of nicotinamide-adenine dinucleotide- and nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase in insect and vertebrate muscles.


Comparison of the stimulatory effects of oligomycin and factor F1-X on the adenosine triphosphate-driven transhydrogenase in A-particles from ox heart mitochondria.


Subcellular fractionation of anaerobically grown Saccharomyces carlsbergensis by zonal centrifugation.


The chemistry of flavins and flavoproteins: aerobic photochemistry. 1. When a mixture of FMN and a reducing substrate (e.g. unprotonated amine) is illuminated oxygen is consumed. 2. The rate of oxygen uptake increases as oxygen concentration falls with some substrates (type I reaction), but with other substrates (typically aromatic compounds) the rate falls as the oxygen concentration falls (type II reaction). 3. The kinetics of type I reactions with EDTA, dl-alpha-phenylglycine and diethanolamine are all consistent with a mechanism in which the rate-determining step, hydrogen abstraction by the FMN triplet, is followed by rapid reoxidation of reduced FMN by oxygen. The reaction is faster at low oxygen concentrations because oxygen quenches the triplet. 4. The sensitivity of reaction rates to substituents in dl-alpha-phenylglycine can be described by a Hammett rho value of -0.6. 5. Individual rate constants for quenching and reaction of the FMN triplet with substrate were calculated (2.4x10(8) and 2.1x10(7)m(-1)s(-1) respectively for EDTA) on the assumption that oxygen quenches the triplet in a diffusion-controlled reaction. 6. The pH-dependences of oxygen uptake rates with six natural amino acids as substrates were measured. 7. Photoinactivations of l-glutamate dehydrogenase and d-amino acid oxidase by FMN were demonstrated.


Subcellular fractionation of aerobically grown Saccharomyces carlsbergensis by zonal centrifugation.


Some problems of classification of psychiatric disorders in relation to the use of psychotropic drugs.


Basic actions of psychoactive drugs.

Basic actions of psychoactive drugs.


Specific blockade of spasmogens by beta-receptor stimulation with nylidrin and isoprenaline.


Cutaneous vascular permeability factors (histamine, 5-hydroxytryptamine, bradykinin) and passive cutaneous anaphylaxis in sheep.


Neuromuscular blocking agents. Replacement of quaternary ammonium groups in bis-onium compounds by amidinium, guanidinium, thiouronium, sulphonium and sulphoxonium groups.


Pharmacological screening of some Brazilian plants.


The absorption, distribution and excretion of pentazocine in man after oral and intravenous administration.


Influence of pretreatment with phenobarbitone on the ultrastructure of adrenergic nerve endings in guinea-pig seminal vesicles.


Ulcerative colitis in rabbits fed degraded carrageenan.


Nicotinic activity of choline.

Nicotinic activity of choline.


Duration of effect of atropine sulphate against the toxicity of oxotremorine in mice.


When is a drug inactive? Concerning the uricosuric activity of some anti-inflammatory drugs.


Inability of dextran to release kinin in rats.


Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain.


Hydroxytryptamine turnover decreased by the antidepressant drug chlorimipramine.


Prevention of experimental gastric ulcer in rats by a substance which increases biosynthesis of acid mucopolysaccharides.


The effect of change of solvent on the critical micelle concentration of a non-ionic surfactant.


Antagonistic effects of dopa and propranolol on brain glycogen.


Differentiation of beta-adrenoreceptors by the use of blocking agents.


The estimation of aqueous solutions of omega-diazoacetophenones by polarography.


Potentiometric determination of sodium using a sodium ion responsive glass electrode.


Prevention of the reserpine effect on rat salivary gland noradrenaline by inhibitors of monoamine oxidase and catechol-O-methyl transferase.


The inhibitory effect of non-steroidal anti-inflammatory agents on aggregation of red cells in vitro.


The interaction of hemicholinium-3 and oxotremorine in isolated organ preparations.


Effects of adrenergic blockade on the vasoconstrictor action of angiotensin in the perfused hind limb.


Role of glucose in facilitating the acute steroidogenic action of adrenocorticotropic hormone (ACTH).


Partial purification of sea nettle (Chrysaora quinquecirrha) nematocyst toxin.


The influence of thyroxine and thiouracil on rats fed excess tyrosine.


Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in axenically maintained adult Schistosoma mansoni.


Conference on population explosion.

Conference on population explosion.


International Symposium on Fluoridation and Preventive Dentistry Summary.


Enzymatic reduction of the azo dye, acid yellow, by extracts of Streptococcus faecalis isolated from rat intestine.


Enzymatic maturation of mouse cerebral neocortex in vitro and in situ.


Metabolism of aflatoxin in susceptible and resistant animal species.


The fine structural changes in the corneal endothelium during graft rejection.


Secretion of a phytohemagglutinin-binding glycoprotein in man.


Binocular interaction in the formation of specific intertectal neuronal connexions.


Some factors affecting the passage of insulin into bile in the rabbit, with some observations on glucagon.


Cytogenetic, anatomical and blood group studies of sheep twin chimaeras.


The relationship between abnormalities of pigmentation and of the inner ear.


Morphological changes in growing colonies of Aerobacter (Klebsiella) aerogenes.


Microvascular supply of the regenerated rat testis following cadmium injury.


Fluoridated water benefits continue: Albert Lea's 1969 Dental Survey.


Personality characteristics of patients with rheumatoid arthritis.


Glucose dehydrogenase from pig liver. I. Isolation and purification.


Prolongation of canine renal homograft survival by post-transplantation treatment with antithymocyte serum.


Purification and properties of glucose-6-phosphate dehydrogenase from the thermophilic fungus Penicillium dupontii.


A modification of D-amino acid oxidase apoenzyme by pyridoxal 5'-phosphate.


Influence of pyridoxine on tyrosine transaminase activity in maternal and fetal rat liver.


Effects of epinephrine and propiomazine used alone and as a mixture on granuloma formation.


The use of the mixed lymphocyte reaction to detect antilymphocytic serum activity.


Dental treatment of patients with hemorrhagic disorders.


Experimental transplantation of the spleen for classical hemophilia A. Rationales and long-term results.


Study on the binding nature of acridine orange to DNA by means of flow dichroism.


Recent advances in molecular pathology: a review of the effects of alcohol on the liver.


Influence of client pretesting on counseling outcome.


Comparison of indicators of homosexuality on the MMPI.


Demonstration of hepatic aneurysms in polyarteritis nodosa by arteriography.


Photooxidation by photosystem II of tris-washed chloroplasts. Irradiation of tris-washed chloroplasts with moderate intensities of red light caused a partial bleaching of chloroplast pigments and an inhibition of the hydroquinone-supported photoreduction of NADP. The presence of an electron donor for photosystem 2 (PS2) during the irradiation prevented the bleaching and inhibition. It is concluded that the strong oxidant produced by PS2 accumulates in tris-washed chloroplasts during irradiation and an electron donor for PS2 protects against the photooxidation reactions.


Experiments in the 5H-dibenzo(a,d)cycloheptene series. IV. Synthesis and pharmacology of some 10-mono and 5,10-disubstituted 5H-dibenzo(a,d)cycloheptenes.


Pharmacology of N-(2-picolyl)-N-phenyl-N-(2-piperidinoethyl)amine (TAT-3), a new antitussive agent.


Parotid tumor.

Parotid tumor.


Prolongation of skin homograft survival in rabbits induced by a combination of epinephrine and a phenothiazine derivative, propiomazine.


Equipping a multi-engined aircraft with a fuselage-mounted spray system for the ultra-low-volume application of malathion.


Coenzyme linked dehydrogenases of acetic acid bacteria.


Antiarrhythmic activity of 1-(di-2,6-xylylmethoxy)-3-(isopropylamino) propanol-2-hydrochloride (BS-7977-d) in the dog heart lung preparation.


Experimental manipulation of sense of competence.


International Commission on Radiation Units and Measurements (ICRU). Abridged report submitted by Lauriston S. Taylor to the International Executive Committee of the XIIth International Congress of Radiology--Tokyo, 1969.


Pharmacology of new antimalarial drugs. A piperazine which exerts an unusual type of adrenergic blockade.


In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing. The in vitro activity of minocycline against 1,028 bacterial strains was determined in parallel in Mueller Hinton Agar and Trypticase Soy Agar. The broad antibacterial effect of minocycline against gram-positive cocci and gram-negative bacilli is confirmed. Minimal inhibitory concentrations for gram-positive bacteria in Mueller Hinton Agar were at least twofold less than in Trypticase Soy Agar. Minimal inhibitory concentrations for gram-negative bacilli in Mueller Hinton Agar were usually fourfold less than in Trypticase Soy Agar.


Purification and characterization of a naturally occurring activator of cholesterol biosynthesis from delta 5,7-cholestadienol and other precursors.


Evidence that Renilla luciferase is not a calcium-triggered photoprotein.


Protection against methyprylon overdosage by catatoxic steroids.


Progress, prospects and provender. Chairman's address before the Council on Arteriosclerosis, American Heart Association, Dallas, Texas, November 12, 1969.


Effect of doxapram hydrochloride on unanesthetized subjects and patients with mild central nervous system (CNS) depression.


Repetitive muscle depolarization from single indirect stimulation in anesthetized man.


Responses of perfused isolated leg preparations of the cockroach, Gromphadorhina portentosa, to L-glutamate, gaba, picrotoxin, strychnine and chlorpromazine.


Antimalarials. 8-chloro-4-(2'-n,n-dibutylamino-1'-hydroxyethyl)benzo[h]-1,6-naphthyridine.


Testing of acid-citrate-dextrose anticoagulant solution for absence of pyrogens.


The in vivo and in vitro effect of diphenylhydantoin and phenobarbitone on K+ activated phosphohydrolase and (Na+, K+)-activated ATPase in particulate membrane fractions from rat brain.


A comparison of larval mosquito species occurrence and light trap data.


Deaths attributable to smallpox vaccination, 1959 to 1966, and 1968.


A correlation of larval surveys and source reduction priorities in Salt Lake County.


Dursban effective for mosquito control in creek bottoms and duck ponds.


Use of flit MLO for urban mosquito control.


Evaluation of concentrated insecticide injections against mosquito larvae in polluted water.


Field tests of Abate and parathion granules in catch basins.


Integration of larval surveillance techniques in the operational program of the Fresno Westside Mosquito Abatement District.


Protein-losing enteropathy in the graft-versus-host reaction.


Methotrexate regimens for control of graft-versus-host disease in dogs with allogeneic marrow grafts.


Specific and nonspecific lymphoid cell proliferation in the pathogenesis of graft-versus-host reactions.


Graft-versus-host inhibition. 3. Fetal thymic factor and fetal liver cells to minimize secondary disease.


Utilization of deoxyribonucleosides by virulent and avirulent Pneumococci.


Studies on the respiratory system of aerobically (dark) and anaerobically (light) grown Rhodospirillum rubrum.


Biochemistry of Coxiella burnetii: 6-phosphogluconic acid dehydrogenase. Purified preparations of the rickettsial agent, Coxiella burnetii, have been examined for their ability to decarboxylate 6-phosphogluconate. The enzyme 6-phosphogluconic acid dehydrogenase [6-phospho-d-gluconate: NADP (nicotinamide adenine dinucleotide phosphate) oxidoreductase (decarboxylating), EC 1.1.1.44] was detected in extracts, but not in whole-cell preparations of C. burnetii. Both extracts and whole cells were shown to be free from contaminating host enzyme activity. Partial characterization of the enzyme has shown that it is substrate-dependent, specific for NADP, and requires magnesium for activity. The pH optimum of the rickettsial enzyme is 8.0.


Massive hemoperitoneum resulting from rupture of a seminoma in an undescended testicle.


Light-induced alterations in retinal pyruvate and high-energy phosphates, in vivo.


Mode of nutrition of the larvae of the filarial nematode Brugia pahangi.


Experimental uterotubovarian homotransplantation in the dog.


The respiratory effects of meperidine and propiomazine in man.


Personality patterns in patients with diabetes mellitus of long duration.


Elongation of fatty acids in Mycobacterium tuberculosis. Cell-free extracts of the H37Ra strain of Mycobacterium tuberculosis contain a soluble enzyme system which catalyzes an elongation reaction of long-chain fatty acids. The predominant reaction involves the addition of a single C(2) unit to the acceptor fatty acid; the elongation takes place exclusively at the carboxyl end of the acceptor molecule. The endogenous acceptor lipid can be removed by solvent extraction of the enzyme system. The lipid-depleted enzyme can be fully reactivated with external acyl coenzyme A, after which elongation with acetyl coenzyme A takes place. The elongation reaction is avidin-insensitive and does not require adenosine triphosphate. Reduced nicotinamide adenine dinucleotide is the source of reducing equivalent, whereas reduced nicotinamide adenine dinucleotide phosphate is without effect.


Involvement of the protocatechuate pathway in the metabolism of mandelic acid by Aspergillus niger. Cell-free extracts of Aspergillus niger UBC 814 grown in the presence of dl-mandelate oxidized both d(-)- and l(+)-mandelate via benzoylformate and benzaldehyde to benzoate. dl-p-Hydroxymandelate was oxidized, presumably through a parallel pathway, to p-hydroxybenzoate. A particulate d(-)-mandelate dehydrogenase and a supernatant fraction l(+)-mandelate dehydrogenase converted their respective substrates to benzoylformate. Both flavine adenine dinucleotide and flavine mononucleotide showed a stimulatory effect on the activity of the l(+)-mandelate dehydrogenase. Benzoylformate was decarboxylated to benzaldehyde by an enzyme requiring thiamine pyrophosphate for maximal activity. Two benzaldehyde dehydrogenases dependent on nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), respectively, for their activity dehydrogenated benzaldehyde to benzoate. In the presence of reduced NADP (NADPH), benzoate was oxidized via p-hydroxybenzoate and protocatechuate. Reduced NAD could not replace NADPH. Sensitive methods of assay for d(-)-mandelate dehydrogenase and benzoylformate decarboxylase are described. The fungal pathway is compared with these systems in bacteria.


Correlation between reduced nicotinamide adenine dinucleotide phosphate levels and morphological changes in Neurospora crassa. A colonial mutant of Neurospora crassa, previously shown to be altered in the structure of glucose-6-P dehydrogenase [a reduced nicotinamide adenine dinucleotide phosphate (NADPH) producing reaction], contained only 40% as much NADPH in extracts as did the wild type. A partial revertant strain, when grown at 23 C, had the same total NADPH content as the wild type, but, at 34 C, had lower levels of NADPH as well as a colonial morphology. A revertant with complete wild-type morphology had wild-type levels of NADPH. Two different colonial mutants, which have also been reported to be altered in NADPH-generating reactions, were found to have a lower content of NADPH, whereas other colonial mutants had wild-type levels. The wild-type strain, when grown under conditions in which it contained a lower total content of NADPH, had a morphology similar to that of a colonial mutant. The evidence indicates that lowered NADPH content leads to a dramatic alteration in the morphology of Neurospora, but not necessarily vice versa. The possible pleiotropic effects of the NADPH deficiency are discussed.


Public health nursing concepts in the basic curriculum.


The tutorial concept permits acceleration in nursing.


Art appreciation and the nurse.

Art appreciation and the nurse.


Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence. Metabolic inhibitors have differential effects on various phases of genetic transformation in pneumococci. Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular "competence." The precise role of this protein(s) in genetic transformation is not known, but it seems essential for some function subsequent to the interaction of competence factor and cells.


Instructional technology and nursing education.


Strategies for developing critical thinking.


The use of the MMPI in describing an inpatient population of merchant seamen.


A severe outbreak of bovine mycotic stomatitis.


Pharmacological evidence of autonomic nerve activities in canine papillary muscle.


Amino acid catabolism in environmental extremes: effect of high altitude and calories.


Distinctive patterns of NADP binding to dimeric and tetrameric glucose 6-phosphate dehydrogenase from human red cells.


Direct fluorophotometric recording of enzyme kinetics in cryostat sections. Glucose 6-phosphate dehydrogenase in the endocrine mouse pancreas.


Regulatory mechanisms involving nicotinamide adenine nucleotides as allosteric effectors. 3. Control of glucose 6-phosphate dehydrogenase.


Identification of O-alkyldihydroxyacetone phosphate, O-alkyldihydroxyacetone, and diacyl glyceryl ethers after enzymic synthesis.


Vasodilation in treatment of hypertension.


Effects of adrenaline and noradrenaline on euglobulin lysis time and effects of adrenergic receptor blocking agents on shortening of lysis time by adrenaline.


New p-di-(2-aminopropyl)-benzene derivatives.


Comparative quantitative studies on cholinolytics. 3. The action of propanteline, methanteline, oxyphenonium and diphemanil.


Control of glycogen and fat metabolism in the mosquito.


Psychological function in individuals with amyotrophic lateral sclerosis (ALS).


The syndrome of the metacentric microchromosome.


Metabolism of human erythrocyte glucose 6-phosphate dehydrogenase. V. Exchange between free and apoenzyme-bound NADP.


Formation and metabolism of 7 alpha-hydroxy-5-alpha-cholestan-3-one and 7 alpha, 12 alpha-dihydroxy-5-alpha-cholestan-3-one in rat liver.


Degradation of phenols by intact cells and cell-free preparations of Trichosporon cutaneum.


Human antilymphocyte serum. 2. Further preparations and in vivo testing.


The organization of motivated and conditioned reflex processes.


Pathomechanism of the side-effects of hydralazine.


Effect of desoxycorticosterone acetate and cortisone on the development of cinchophen ulcer in the dog.


Enzymatic conversion of isopentenyl pyrophosphate-4-14C and phytoene-14C to acyclic carotenes by an ammonium sulfate-precipitated spinach enzyme system.


Early penetrating corneal retransplantation.


Study of biological pigments by single specimen derivative spectrophotometry. The single specimen derivative (SSD) method provides an absolute absorption spectrum of a substance in the absence of a suitable reference. Both a reference and a measuring monochromatic beam pass through a single sample, and the specimen itself acts as its own reference. The two monochromatic beams maintain a fixed wavelength difference upon scanning, and the difference in absorbance of the two beams is determined. Thus, the resulting spectrum represents the first derivative of the conventional type absorption spectrum. Tissues and cell fractions have been examined at room and liquid N(2) temperature and chromophoric molecules such as the mitochondrial cytochromes and blood pigments have been detectable in low concentrations. In the case of isolated cellular components, the observed effects of substrates and inhibitors confirm similar studies by conventional spectrophotometry. The extension of the SSD concept to the microscopic level has permitted the study of the tissue compartmentalization and function of cytochromes and other pigments within layered tissue.


Enzymes and metabolites of intermediary metabolism in urea-fed sheep.


Effects of brocresine on Zollinger-Ellison syndrome. Report of 2 cases.


Biosynthetic control of the diurnal rhythm of tyrosine alpha-ketoglutarate transaminase activity in rat liver.


On the mechanism of the light-induced activation of the NADP-dependent glyceraldehyde phosphate dehydrogenase.


Mn2+ as electron donor in isolated chloroplasts.


Pig atherosclerosis. Effect of the antihistamine, chlorpheniramine, on atherogenesis and serum lipids.


Cell division during dedifferentiation and redifferentiation in the regenerating isolated gastrodermis of Hydra.


Children's oral problems in Costa Rica and programs leading to their solution.


The effect of terbutaline (PINN) 1-(3,5-dihydroxyphenyl)-2-(t-butylamino)-ethanol on the choledochoduodenal sphincter.


Council classifies colgate with MFP (sodium monofluorophosphate) in group A.


Pheochromocytoma.

Pheochromocytoma.


Control and use of scientific information.


Water reclamation by reverse osmosis. AMRL-TR-68-190.


Biocidal rubber for water reclamation systems. AMRL-TR-69-17.


Effect of space environment on man's response to infection; a review of literature and annotated bibliography. NASA CR-1487.


Factors influencing the time of safe unconsciousness (TSU) for commercial jet passengers following cabin decompression.


Satuation exposures at 31 ATA in an oxygen-helium atmosphere with excursions to 36 ATA.


The mediation of the canine prostatic secretion provoked by hypogastric nerve stimulation.


Inhibitory beta adrenergic receptors in the human distal esophagus.


Enzymes of the nonphosphorylative (sorbitol) pathway for fructose biosynthesis in primate seminal vesicles.


Daily rhythms in content and utilization of tyrosine in the whole mouse.


Occurrence, function and biosynthesis of wax esters in marine organisms.


Treatment of Menière's disease.

Treatment of Menière's disease.


Fluorimetric technique for monitoring changes in the level of reduced nicotinamide nucleotides in continuous cultures of microorganisms. A metabolite fluorimeter was modified to monitor nicotinamide nucleotides in cells growing in a chemostat culture. By illuminating and collecting fluorescence over a relatively large area of the side of the culture vessel, the noise level was kept low even in highly turbulent cultures. Calibration of the system was by enzymatic assay of samples. Changes in nicotinamide nucleotide of concentration less than 0.1 nmoles/ml could be detected [i.e., less than 10% aerobic/anaerobic response for a cell concentration of 5 mg (dry wt) per ml].


Effect of temperature on toxicity and cardiac chronotropic action of sympathicotropic drugs.


The action of practolol and propranolol on the rabbit isolated atrium.


Effect of some drugs on the responses of the vas deferens and seminal vesicle to hypogastric nerve stimulation in guinea-pig in vivo.


Blood flow and volume distribution following alpha adrenergic blockade.


Effect of adrenergic blocking agents on response of rabbit arterial and venous strips to catecholamines.


Stimulation of renal vascular "alpha-receptors" with isoproterenol.


Associations of Wiscosin mosquitoes and woodland vertebrate hosts.


Brachial and crural blood pressure during general anaesthesia.


Parasitic disease of surgical importance.


Studies on tetrahydroisoquinolines (THI). VI. Effects of trimetoquinol on tracheal and some other smooth muscles.


Plasma free fatty acid levels during general anaesthesia and operation in man.


Glutamate dehydrogenase of nuclear and extra-nuclear compartments of Chang's liver cells.


Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma. Twenty patients with extrinsic type bronchial asthma are shown to have a significant fall in vital capacity (V.C.) and forced expiratory volume in 1 second (F.E.V.(1)) after an intravenous infusion of 50mug. of histamine dihydrochloride. In 10 of these subjects the fall in V.C. and F.E.V.(1) produced by intravenous histamine is inhibited by the alpha-receptor blocking drugs phentolamine and phenoxybenzamine injected before the histamine test. The inhalation of disodium cromoglycate in 10 subjects is also shown to inhibit the fall in V.C. and F.E.V.(1) produced by the intravenous infusion of histamine. It is suggested that bronchial smooth muscle in asthmatic subjects has alpha-adrenergic receptor sites, and that a possible mechanism for the action of disodium cromoglycate is that it stabilizes the cell membrane, thereby altering calcium ion transport.


Comparative aspects of fatty acid synthesis in Bacillus subtilis and Escherichia coli.


Role of molybdenum in the regulation of nitrate reductase in Neurospora crassa.


Mechanism of malate utilization in Ascaris-muscle mitochondria.


Characteristics of male undergraduate registrants of firearms.


Action of antibiotics on respiratory tract. I. Ampicillin.


Interaction of amine drugs with a polycarboxylic acid ion-exchange resin.


The appearance and disappearance of the post-transcriptional repressor of tyrosine aminotransferase synthesis during the HTC cell cycle. The synthesis of the enzyme tyrosine aminotransferase in HTC cells (an established line of rat hepatoma cells) is inducible by glucocorticoid hormones only during the latter part of G1 phase and throughout S phase in the cell generation cycle. We have earlier shown that during the first few hours of G1 phase when the enzyme cannot be induced, its synthesis is constitutive, presumably using as template, preexisting messenger RNA. Our model for tyrosine aminotransferase gene regulation in eukaryotic cells entails a specific post-transcriptional repressor which is formed only during the periods in the cell cycle when tyrosine aminotransferase is inducible. This model predicts that during the noninducible period, G2, the tyrosine aminotransferase repressor would not be present and thus tyrosine aminotransferase synthesis would be constitutive. Data are presented which confirm this prediction in further support of the model.


The binding of reduced nicotinamide adenine dinucleotide phosphate to mammalian and avian fatty acid synthetases. Number of binding sites and the effect of reagents and conditions on the binding of reduced nicotinamide adenine dinucleotide phosphate to enzyme.


Recent investigations on sea-wasp stingings in Australia.


A warm welcome in a cold city.

A warm welcome in a cold city.


The pharmacologic basis of bronchospasmolytic agents.


Neuropsychological patterns in multiple sclerosis.


Personality trait dependent performance under psilocybin. II.


Inhiition of neuronally induced tyrosine hydroxylase by nitinic receptor blockade.


Charateristics of induced benzpyrene hydrylase activity in the rat foeto-placental unit.


Beta-adrenergic blocking agents. 8. Reactions of beta-haloalkylamines related to pronethalol and propranolol.


Antimalarials. II. Quinolinemethanols with decreased phototoxicity.


The effect of bretylium on amine retention in rat heart.


An evaluation of the vasodilation produced by mephentermine and certain other sympathomimetic amines.


Intraocular penetration of cephalexin in man.


Gluconeogenesis in the cow. The effects of a glucocorticoid on hepatic intermediary metabolism. 1. The hepatic concentrations of the ketone bodies and of metabolites and activities of enzymes involved in gluconeogenesis were measured in healthy lactating and non-lactating cows 48h after administration of Voren, an ester of dexamethasone, and compared with those found in control animals given saline. Parallel measurements were also made of the blood concentrations of several of the metabolites. 2. Blood glucose concentrations were raised in the Voren-treated animals, whereas blood ketone body and free fatty acid concentrations were unaltered. Similarly there was no change in the hepatic concentrations of the ketone bodies. 3. Significant increases were found in the hepatic concentrations of citrate, 2-oxo-glutarate and malate in both groups of animals given Voren. 4. The hepatic concentrations of those glycolytic intermediates that were measured either decreased or did not change after Voren treatment. 5. The enzymes aspartate transaminase and fructose 1,6-diphosphatase were unchanged in activity after Voren administration, whereas phosphopyruvate carboxylase (EC 4.1.1.32) activity was depressed in the lactating group. However, glucose 6-phosphatase, tryptophan oxygenase and tyrosine aminotransferase increased in activity. 6. In several cases those hepatic metabolites that increased in concentration after Voren administration were present in lower concentration in normal lactating cows than in normal non-lactating cows. The same applied mutatis mutandis to those metabolites that were decreased by Voren. 7. These findings are discussed in relation to the use of glucocorticoids in the treatment of bovine ketosis.


Nuclear magnetic resonance study on D-amino acid oxidase reaction.


Preparation and properties of an electrophoretically homogeneous monoamine oxidase from monkey intestine.


Tyrosine transaminase: inactivation by tyrosine metabolic end products.


Comparison of the effects of propranolol and MJ 1999 on cardiac beta-adrenoceptors in man. 1. Propranolol, a beta-adrenoceptor blocking drug with local anaesthetic and a direct myocardial depressant action, and MJ 1999, a beta-adrenoceptor blocking drug which has no local anaesthetic or intrinsic sympathomimetic action, were compared for beta-adrenoceptor blocking activity in man.2. Propranolol was 2.67 times more active than MJ 1999 in reducing by 50% the tachycardia produced by the intravenous infusion of isoprenaline in healthy volunteers.3. Propranolol and MJ 1999 intravenously both reduced resting heart rate in the standing position and an exercise tachycardia, but there was no qualitative or quantitative difference between them.4. On oral administration, both propranolol and MJ 1999 reduced resting heart rate and an exercise induced tachycardia; propranolol was only slightly more active than MJ 1999.5. In patients with thyrotoxicosis propranolol was about twice as active as MJ 1999 in reducing the heart rate.


Studies on the blocking action of 2-(4-phenyl piperidino) cyclohexanol (AH5183). 1. AH5183 (2-(4-phenyl piperidino) cyclohexanol) produced neuromuscular block of slow onset in rapidly stimulated nerve-skeletal muscle preparations of the rat, chicken and cat.2. The neuromuscular block was not antagonized by neostigmine, tetraethylammonium (TEA) or choline. The rate of onset of transmission failure was enhanced by factors which increase the release of acetylcholine.3. It was concluded that the neuromuscular blocking activity was primarily pre-junctional in origin, being due either to a non-competitive action on the choline transport mechanism, or to an intracellular action on acetylcholine metabolism.4. In high doses AH5183 possessed local anaesthetic activity, but this was considered insufficient to bring about the failure of neuromuscular transmission.5. AH5183 also produced a block of sympathetically innervated preparations that was indistinguishable from that produced by an alpha-adrenoceptor blocking drug.


The effect of catecholamine infusions on myocardial blood flow, metabolic heat production and on general haemodynamics, before and after alprenolol (H56-28), in anaesthetized cats. 1. In cats anaesthetized with pentobarbitone sodium, infusions of adrenaline, noradrenaline (0.5 mug/kg per min) and isoprenaline (0.25 mug/kg per min) increased myocardial blood flow, myocardial heat production, left ventricular systolic and end-diastolic pressures, left ventricular +ve and -ve dp/dt max, and calculated cardiac output, effort and oxygen consumption. These effects (apart from the effect of noradrenaline on left ventricular systolic pressure) were markedly reduced by previous administration of alprenolol (0.5 or 1.0 mg/kg).2. Infusions of adrenaline and noradrenaline increased arterial diastolic blood pressure and isoprenaline reduced it. After alprenolol the effects of adrenaline and noradrenaline were potentiated and that of isoprenaline abolished; in some experiments isoprenaline increased arterial diastolic pressure after alprenolol. Alprenolol did not influence the increases in arterial systolic pressure which followed the administration of adrenaline and noradrenaline.3. Isoprenaline-induced tachycardia was markedly reduced and adrenaline tachycardia was converted to bradycardia after alprenolol. The bradycardia which occurred during noradrenaline infusions was unaffected.4. After blockade by alprenolol, recovery of the effects of isoprenaline on left ventricular dp/dt and on heart rate occurred more quickly than recovery of the effects on arterial diastolic pressure. This suggests that alprenolol has a greater affinity for beta(2)- than for beta(1)-adrenoceptors.5. Intravenous administration of acetylcholine decreased arterial blood pressure, left ventricular pressure and +ve and -ve dp/dt max. During recovery from these effects there was a marked increase in +ve dp/dt max. which was absent after the administration of alprenolol (0.5 mg/kg). Because this dose of alprenolol is thus able to block the effects of reflex sympathetic cardiac nerve stimulation but does not completely antagonize the effects of exogenous adrenaline on dp/dt, it is suggested that alprenolol may have some adrenergic neurone blocking activity.6. Increases in liver and myocardial blood flow and heat production produced by noradrenaline, adrenaline and isoprenaline were reduced after alprenolol.7. Isoprenaline reduced air-way resistance and this effect was abolished by alprenolol; increases in air-way resistance produced by adrenaline and nor-adrenaline were augmented. All three amines inhibited intestinal smooth muscle contractions in vivo. Only the effect of isoprenaline was reduced by alprenolol.


Hypertrophic subaortic stenosis as a complication of fixed obstruction to left ventricular outflow.


Supraventricular tachycardia during left ventricular angiocardiography treated with practolol.


Reduction of increased vascular permeability by calcitonin.


Proteins in excitable membranes: their properties and function in bioelectricity are discussed.


Use of drugs to protect against fetal asphyxia.


Psychiatry in the United Kingdom.

Psychiatry in the United Kingdom.


Prevention of death after renal transplantation. I. Recognizable patterns leading to death in long-term survivors.


Meta- and para-hydroxy-1-cyanophenethylamines.


The effect of some drugs on oxalic acid excretion in urine.


A sensitive and specific assay for vasopressin in the circulating blood. 1. A search was made for an assay tissue with selective sensitivity to vasopressin. Of those smooth muscle preparations tested, the longitudinal muscle of the isolated rectum of the rabbit was the most satisfactory.2. The rabbit isolated rectum, bathed in Krebs solution, was contracted by acetylcholine, angiotensin II amide, bradykinin and 5-hydroxytryptamine. It was relaxed by vasopressin, oxytocin and the catecholamines.3. Vasopressin was active in concentrations of 4-100 muu./ml (0.01-0.25 ng/ml) and was 20-30 times more active than oxytocin. Bretylium had no effect on the relaxant action of vasopressin; nor did concentrations of alpha- and beta-adrenoceptor blocking agents sufficient to abolish the actions of catecholamines. Lignocaine reduced the sensitivity of the rabbit rectum to both vasopressin and oxytocin without altering the actions of adrenaline. High concentrations of either vasopressin or oxytocin desensitized the rabbit rectum to the actions of both hormones, without affecting the actions of adrenaline. It was concluded that vasopressin and oxytocin act on a common population of receptors different from those for catecholamines.4. Phentolamine, unlike other alpha-adrenoceptor antagonists, reduced the relaxant action of vasopressin on the rectum.5. When superfused with blood from an anaesthetized dog, the rabbit rectum maintained a higher tone than in Krebs solution; it retained its sensitivity to vasopressin. Pronethalol, administered intraluminally, reduced spontaneous movement and abolished the actions of low concentrations of catecholamines, thereby increasing the specificity of the assay. No other substance tested relaxed the rectum in concentrations likely to be found in blood.6. Vasopressin was stable in dog's blood; it survived passage through the pulmonary vascular bed; it had a half-life in the circulation of about 1 min.7. The half-life of vasopressin in the circulation may depend upon the duration of the infusion.


A controlled study of LSD treatment in alcoholism and neurosis.


Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle. 1. Alprenolol, a beta-adrenoceptor blocking drug reported to have the same potency as propranolol in vitro and in vivo, was found to be four times more active than procaine as a local anaesthetic on frog sciatic nerve.2. At doses of 0.125 mg/kg and above alprenolol protected anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation.3. In isolated rabbit atria, resting potentials were unchanged, and the duration of the action potential was not prolonged, by concentrations of alprenolol up to 10.5 x 10(-6)M. The maximum rate of depolarization (MRD), however, was reduced by 30% at a concentration of 0.525 x 10(-6)M. This was 214 times less than the concentration which reduced the frog action potential height by 25%.4. The concentration of alprenolol required to produce more than 15% decrease in contraction or maximum driven frequency was 3.5 x 10(-6)M.5. As a test of the direct action of alprenolol on isolated cardiac muscle, MRD was also a more sensitive test than the measurement of electrical threshold or conduction velocity.


Occurrence of free porphyrins in certain coelenterates.


Effects of hydrocortisone and growth hormone on tyrosine aminotransferase and tryptophan oxygenase levels in hypophysectomized rats.


Effects of salicylate on RNA polymerase activity and on the incorporation of orotic acid and thymidine into the nucleic acids of rat foetuses in vitro.


Preparation of active, drug-metabolizing, microsomal enzymes under optimal conditions and by iso-electric precipitation.


Simultaneous determination of the effect of a non-ionic surfactant on the dissolution rate and biological activity of tablets of chlorpromazine hydrochloride.


Stereochemical influences upon antihistamine activity. Further studies of isomeric 4-amino-1,2-diarylbutenes.


Phosphocholine 2,6-xylyl ether bromide: proton-phosphorus coupling constants and preliminary pharmacological assessment.


Effect of tetracycline, polymyxin B, and rifampin on phagocytosis.


The mode of action of insulin potentiation by mebanazine.


A test for the assessment of the duration of the action of neostigmine and of the relative potencies of various anticholinesterases using the pupil of the mouse.


A comparison of the local anaesthetic-, "quinidine-like"- and adrenergic beta-blocking-activities of five beta-receptor antagonists.


Response of female mice to anticonvulsants after pretreatment with sex steroids.


Prostaglandins in dog renal medulla.

Prostaglandins in dog renal medulla.


3-Ethyl-8-methyl-1,3,8-triazabicyclo(4,4,0)decan-2-one: a new antifilarial agent.


The effect of ovariectomy on the gamma-aminobutyric acid content in the cerebral hemispheres of young rats.


An isotonic transducer for general use.

An isotonic transducer for general use.


Effects of a marihuana homologue (Pyrahexyl) on avoidance learning in the gerbil.


L-dopa induced changes in central monoamine neurons after peripheral decarboxylase inhibition.


Reversal by trypsin of the action of a 2-haloalkylamine.


The influence of pulsation on the dissolution rate measurements in column type apparatus.


The effects of stress and intravenous 0.9 per cent NaCl injection on concentrations of whole brain 5-hydroxytryptamine in the neonate chick.


Menstrual irregularity, symptoms and personality.


Natural and induced malarias in western hemisphere monkeys.


One-day treatment for lobar pneumonia.

One-day treatment for lobar pneumonia.


Some properties of the ATP receptors of Glossina austeni.


Enzymes in trypanosome extracts.

Enzymes in trypanosome extracts.


Nucleoside trypanocides and Trypanosoma congolense.


Ricefields and mosquito populations, Kano Plain, Kenya.


Cultivation in vitro of sporozoites of Plasmodium berghei.


Clinical course of keratoconus.

Clinical course of keratoconus.


Cofactor requirements and general characteristics of a soluble fatty acid elongating system from mitochondria.


Identification of possible intermediates in the mitochondrial fatty acid chain elongation system.


Degradation of steroids by intestinal bacteria. II. Enzymes catalysing the oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl group.


Medium-chain fatty acyl-CoA requirement for long-chain fatty acid synthesis in some anaerobic bacteria.


Delta-aminolevulinic acid synthetase. 3. Synergistic effect of chelated iron on induction.


The involvement of the thioredoxin system in the reduction of methionine sulfoxide and sulfate.


Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. 3. Transient formation of phospholipid peroxides.


Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.


Early actions of cadmium in the rat and domestic fowl testis. I. Testis and body temperature changes caused by cadmium and zinc.


Family study in home dialysis.

Family study in home dialysis.


The treatment of salicylate poisoning using mannitol and forced alkaline diuresis.


Clinical efficacy of a self-applied stannous fluoride prophylactic paste.


Comparative effectiveness of anti-lymphocyte serum (A.L.S.) and imuran with respect to suppression of hemagglutinin formation and skin homograft rejection.


Maternal modification of tissue antigenicity and the graft-versus-host reaction.


Immune response in tumor-bearing patients and animals. IV. Immunological competence in lymphoid cells of tumor-bearing mice.


Excitation of autonomic nerve fibers in the canine papillary muscle.


Auxiliary partial liver transplantation in Macaca mulatta.


The effect of cofactors on steroid biosynthesis in normal ovarian tissue.


The university and social needs of the 70's.


Testing for health. Multiphasic screening program.


Hiatal hernia after vagotomy.

Hiatal hernia after vagotomy.


Primary hemangioma of the pericardium.

Primary hemangioma of the pericardium.


Medical aspects of professional basketball.


The other side of the coin.

The other side of the coin.


Maternal mortality in Chicago. Chicago Board of Health Maternal and Infant Care Project 502 interim report.


What "generation gap"?

What "generation gap"?


The growth of forensic pathology in Illinois.


Nicotinamide adenine dinucleotide as an active site director in glyceraldehyde 3-phosphate dehydrogenase modification.


5-keto-D-fructose. VI. A specific reduced nicotinamide adenine dinucleotide phosphate-linked reductase from yeast.


Dexamethasone phosphate-induced synthesis of tyrosine aminotransferase in hepatoma tissue culture cells. Studies of the early phases of induction and of the steroid requirement for maintanance of the induced rate of synthesis.


The effect of polyinosinic-polycytidylic acid upon graft-vs-host activity in BALB/c mice.


The effect of parathyroid hormone on the concentration of adenosine 3',5'-monophosphate in skeletal tissue in vitro.


A look ahead at transplantation.

A look ahead at transplantation.


Influence of propericiazine on the behavior of difficult delinquents.


Spacecraft cabin radiation distributions for the fourth and sixth Gemini flights.


Psychiatric disorders affecting civil aircrew in the fifth and sixth decades.


A comprehensive summary of dose rate measurements aboard the fourth and sixth Gemini flights.


Psychological measures in aircrew.

Psychological measures in aircrew.


Sex chromosome mosaicism in 3 sibs. Clinical and pathologic aspects.


Nursing research.

Nursing research.


Vitamin K3-dependent NADPH oxidase of liver microsomes. Purification, properties, and identity with microsomal NADPH-cytochrome c reductase.


A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes.


5-Hydroxytryptamine, histamine and N-acetyl-histamine in the nervous system of Dosidicus gigas.


Properties of rat brain NAD-kinase.

Properties of rat brain NAD-kinase.


Respiration and glucose oxidation in human and guinea pig leukocytes: comparative studies. A comparison has been made of the metabolic shifts in human and guinea pig leukocytes when they phagocytize. Respiration of guinea pig polymorphonuclear leukocytes (PMN) and the increment during phagocytosis were each about 2(1/2)-fold that of human PMN. This was also true of the direct oxidation of glucose-6-P (hexose monophosphate shunt). Enzymes potentially responsible for these phenomena have been compared in each species. Cyanide-insensitive NADH oxidase and NADPH oxidase were measured and only the formed exhibited adequate activity to account for the respiratory stimulus durintg phagocytosis. The hydrogen peroxide formed by this enzyme stimulates the hexose monophosphate shunt by oxidizing glutathione which upon reduction by an NADPH-linked glutathione reductase provides NADP to drive the hexose monophosphate shunt. Other linkages between respiratory stimulation and that of the hexose monophosphate shunt also pertain in the guinea pig.


Stimulation of piriform- and neo-cortical tissues in an in vitro flow-system: metabolic properties and release of putative neurotransmitters.


Differences in the regulation of tyrosine aminotransferase in brain and  liver.


Urinary steroid excretion in cryptorchidism in the pig.


A Philippino glucose-6-phosphate dehydrogenase variant (G6PD Union) with enzyme deficiency and altered substrate specificity.


Clinical experience with dextro-alprenolol. Experience with dextro-alprenolol in nine patients has shown that it is relatively ineffective in treating arrhythmias associated with acute myocardial infarction. Marginal effectiveness in the control of ventricular ectopic beats after myocardial infarction is outweighed by an appreciable hypotensive effect with risk of infarction. The drug was ineffective in the management of supraventricular arrhythmias.


Leucocyte antigens in renal transplantation: 9. Matching for the HL-A system and the early course of cadaveric renal grafts.


Ulcerative colitis: the experience of a Sydney teaching hospital.


Improvement in renal blood flow of rejecting renal allografts during heparin infusion.


The management of Parkinsonism.

The management of Parkinsonism.


Characteristics of guinea pig liver and adrenal monooxygenase systems.


Donor-recipient pairing for transplantation: present limitations and future objectives.


Stem cells circulating in the blood.

Stem cells circulating in the blood.


Bone marrow transplantation in lymphopenic immunological deficiency disease.


The role of beta adrenergic blockade in the treatment of septic shock.


Severe reactions after cryoprecipitated human factor VIII.


Etiology, pathogenesis, and prevention of a fatal host-versus-graft syndrome in parent-F1 mouse chimeras.


Heterotopic heart and lung transplantation in the rat.


Reversible inactivation of Azotobacter vinelandii TPN+ -isocitrate dehydrogenase by the formation of an intramolecular disulfide bridge.


Evaluation of a new procedure for measuring serum creatine kinase activity.


Adipose tissue metabolism: influence of periodicity of eating and diet composition.


Metabolic functions affecting the contribution of adipose tissue to total energy expenditure.


Immunologic mechanisms in bovine paratuberculosis.


A controlled study of the effects of diphenylhydantoin on anxiety, irritability, and anger in neurotic outpatients.


Premedication of children with promethazine, propiomazine, and mepazine: comparison of oral and intramuscular routes.


Methodological considerations in the histamine skin test.


Comparative evaluation of benzoctamine and diazepam in treatment of anxiety.


A spectrophotometric asay for cellobiase.


Metabolism of the obligatory aerobic yeast Rhodotorula gracilis. I. Changes in metabolite concentrations following D-glucose and D-xylose addition to the cell suspension.


The evidence of gene duplication for S-form NADP-linked isocitrate dehydrogenase in carp and goldfish.


Control of liver tyrosine aminotransferase expression: enzyme regulatory studies on inbred strains and mutant mice.


Variation of glucose 6-phosphate dehydrogenase in the HeLa and Detroit 98 cell lines and their clonal derivatives.


Alprenolol in acute myocardial infarction: Double-blind trial.


The aetiology of Polyareritis nodosa: A review.


A cytotoxic serum factor in polyarteritis nodosa and related conditions.


"Salazopyrin" in the treatment of granular proctitis.


The abolition of tolerance of skin homografts in rats with isoantiserum.


Anti-pneumococcal polysaccharide type 3 hemolytic plaques in mice: cellular response in immunity and immunologic paralysis.


Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum.


Category width and acquiescence.

Category width and acquiescence.


Congenital absence of the abdominal muscles: a clinicopathologic correlation.


Treatment of edema disease of swine.

Treatment of edema disease of swine. Antihistamine (Allermin) was used sucessfully in the treatment of naturally occurring edema disease of swine under the field and laboratory conditions. A high recovery rate (88.8%) was obtained in the group of pigs with mild clinical signs. The intravenous route of Allermin administration had definite beneficial value. The release of histamine induced by circulating immune-complexes may be responsible for the clinical signs characteristic of edema disease. Three pigs that recovered clinically following the Allermin treatment were examined histologically. Fibrinoid persisted in the vascular walls at least 30 days after the initiation of the treatment. The fibrinoid vasculitis, generalized eosinophilia at the tissue level, and favorable response of pigs to antihistamine treatment suggest that edema disease may be caused by allergy.


Bacterial colonization of newborn infants and subsequent acquisition of hospital bacteria.


Personality characteristics of mental health center patients classified by referral source.


Metabolic adaptation in the brain.

Metabolic adaptation in the brain.


Mechanisms of rat renal allograft enhancement by antigen and antibody.


A test to measure the immunosuppressive potency of antilymphocyte sera.


Maintenance of cardiac output despite deliberate hypotension.


Germinal cell deficiency of the undescended testis: a congenital defect.


Empyema necessitatis.

Empyema necessitatis.


Effect of thioproperazine (Majeptil) on some Wechsler Bellevue Subtests.


Testosterone metabolism by homogenates of human and rat placenta.


A study of the concentration of pyridine coenzymes in the human corium with special referenec to Dermatitis herpetiformis.


Divergent phenotypes among 48,XXXX and 47,XXX females.