Interaction between ferredoxin and ferredoxin nicotinamide adenine dinucleotide phosphate reductase in pyridine nucleotide photoreduction and some partial reactions. II. Complex formation between ferredoxin and ferredoxin nicotinamide adenine dinucleotide phosphate reductase and its relevance to pyridine nucleotide photoreduction.


Albert F. A. King (1841-1914), an armchair scientist.


Studies on the influence of centrophenoxin on bioelectrical activity of the rabbit brain in sodium cyanide intoxication.


Effect of steroid hormone on activation of Endoxan (cyclophosphamide).


Conformation and conformational changes of reduced diphosphospyridine nucleotide in solution.


Mechanism of carcinogenesis with 1-aryl-3,3-dialkyltriazenes. Enzymatic dealkylation by rat liver microsomal fraction in vitro.


Oxidation of 5-beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol by rat-liver mitochondria.


The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. I. Reaction with 5,5'-dithiobis(2-nitrobenzoic acid).


Further studies on corticosteroidogenesis. V. 11 Beta-hydroxylation of deoxycorticosterone by mitochondria incubated with malate, supernatant fraction and supernatant fraction+pyruvate+CO2.


Effect of thyrotropin on thyroid pyridine nucleotides in vitro.


Observations of spontaneous contractions of the cat ovary in vitro.


Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.


The survival time for different bacteria in various transport media.


Histoenzymology of the antidiuretic centres.


The genera Campanella P. Henn. and Dictyoploca (Mont.) Heim.


The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Binding of threonine and of pyridine nucleotides: stoichiometry and optical effects.


The International Union against Tuberculosis.


A specific and sensitive method for the determination of NADPH.


Inhibition of insect nerve cord phosphorylase activity by 5-hydroxytryptamine.


Reaction patterns of dark- and light-adapted Hydra to light stimuli.


Effect of a disulfide reducing agent on coelenterate nematocyst capsules.


Illinois Department of Public Aid payment procedures and policies explained. VI. Of a series.


Physical behavior of pneumolysin.

Physical behavior of pneumolysin. Pneumolysin behaved as an acidic protein having an isoelectric pH of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.


Inhibition of circulating antibody formation induced by propiomazine and epinephrine combination.


Alteration in the magnitude of induction of tyrosine transaminase by glucocorticoids. II. Effects of phenobarbital, o,p' DDD and diethylaminoethyl diphenylpropylacetate (SKF 525A) on metabolism of triamcinolone acetonide.


A new hepatic protein inactivating glucose 6-phosphate dehydrogenase. Two NADP-cleaving enzymes, namely NADP glycohydrolase and NADP pyrophosphatase, are present in a rat liver extract that inactivates G6PD (glucose 6-phosphate dehydrogenase). The following results suggest that a third G6PD-inactivating protein is present in this extract. (1) Nicotinamide, which selectively inhibits NADP glycohydrolase, enhances the G6PD inactivation under conditions where G6PD activity in control experiments is rather stable. (2) DEAE-cellulose adsorbs the bulk of both NADP glycohydrolase and NADP pyrophosphatase, whereas most of the G6PD-inactivating ability is unadsorbed. (3) Out of 37 liver extracts that were prepared, two were found to lack NADP pyrophosphatase. After removal of NADP glycohydrolase from these extracts by centrifugation, they were still found to inactivate G6PD. (4) Deproteinization of DEAE-cellulose supernatants results in a complete loss of G6PD-inactivating ability; moreover, kinetic experiments performed with the extracts lacking pyrophosphatase strongly support the view that the inactivating protein is an enzyme, although its mechanism is not clear. (5) NADP protects G6PD from inactivation and also reactivates the enzyme completely, thus supporting the view of some action of the inactivating protein on the G6PD-bound NADP.


Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine. 1. Whole cells of Pseudomonas AM1 grown on methylamine oxidize methylamine, formaldehyde and formate. Crude extracts oxidize methylamine only if supplemented with phenazine methosulphate. 2. By using a spectrophotometric assay, the methylamine-oxidizing enzyme has been purified 20-fold in 31% yield. 3. The enzyme is a dehydrogenase, unable to utilize oxygen, NAD, NADP, flavines or menadione as electron acceptors, but able to utilize phenazine methosulphate, ferricyanide, cytochrome c or brilliant cresyl blue. 4. The enzyme is non-specific, readily oxidizing aliphatic monoamines and diamines, histamine and ethanol-amine. Secondary and tertiary amines, quaternary ammonium salts and aromatic amines are not oxidized. 5. The pH optima for methylamine, n-pentylamine and putrescine are respectively 7.6, 8.0 and 8.5. 6. The K(m) value for methylamine is 5.2mum and that for phenazine methosulphate 56mum. 7. The enzyme will withstand heating for 15min. at 80 degrees without loss of activity, but is inactivated at higher temperatures. It is not inactivated by any pH value between 2.6 and 10.6. 8. The dehydrogenase is inhibited by semicarbazide (K(i) 3.35mum), isoniazid (K(i) 1.17mum), cuprizone (K(i) 0.49mum), p-chloromercuribenzoate (K(i) 0.45mm) and quinacrine (K(i) 12.1mm). 9. The enzyme is absent from succinate-grown cells, and, during adaptation from succinate to methylamine, activity appears before growth on methylamine begins.


The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride. 1. The effects of several phenothiazine derivatives on lipid-peroxidation systems in rat liver microsomes were studied and the results are considered in relation to the hepatotoxic action of carbon tetrachloride. 2. The lipid-peroxidation system coupled to NADPH(2) oxidation and stimulated by an ADP-Fe(2+) mixture is strongly inhibited in vitro by promethazine (50% inhibition at 29mum). Chlorpromazine and Stelazine also inhibit the peroxidation system but are less effective than promethazine. 3. The effects of promethazine on three other systems involving oxygen uptake (sulphite oxidation, orcinol oxidation and mitochondrial succinate oxidation) were also studied. Promethazine does not inhibit these systems to the same extent as it does the NADPH(2)-ADP-Fe(2+) lipid-peroxidation system. 4. Promethazine also produces an inhibition of the NADPH(2)-ADP-Fe(2+) system in liver microsomes after administration in vivo. It is concluded that the inhibition involves the interaction of the drug (or a metabolite of it) with the microsomal electron-transport chain. 5. Several other compounds known to protect the rat against liver necrosis after the administration of carbon tetrachloride were tested for inhibitory action on the NADPH(2)-ADP-Fe(2+) system. No clear correlation was observed between effectiveness in vivo as a protective agent and inhibitory effects on the NADPH(2)-ADP-Fe(2+) system in vitro. 6. Promethazine was found to inhibit the stimulation of lipid peroxidation produced in rat liver microsomes by low concentrations of carbon tetrachloride. This effect occurs at a concentration similar to that observed in vivo after administration of a normal clinical dose.


Anaphylatoxin tachyphylaxis and anaphylaxis.


Studies on heart anaphylaxis. I. Effect of antigen and histamine on the guinea pig heart-lung preparation.


A two-year comparison of hand and electric toothbrushes.


Adrenoreceptors in the cardiovascular system of the domestic fowl.


Pharmacological investigation of the mechanism of conditional salivation in dogs induced by atropine and morphine.


Diagnostic tests for the Zollinger-Ellison syndrome.


Enhancement of gastrointestinal absorption of a quaternary ammonium compound by trichloroacetate.


Physiological and hygiene problems involved in the study of enclosed and sealed environments.


Physiology of changes in pressure.

Physiology of changes in pressure.


One-electron-transfer reactions in biochemical systems. 3. One-electron reduction of quinones by microsomal flavin enzymes.


Aerobic and anaerobic respiration in Micrococcus denitrificans.


The effect of amino acid mixtures, insulin, epinephrine and glucagon in vivo on the levels of rat liver tyrosine aminotransferase.


MMPI correlates of sensation-seeking in male alcoholics: a test of Quay's hypothesis applied to alcoholism.


Sources of disagreement in the perception of psychotherapy outcomes.


Collegiate normative data on MMPI content scales.


Figure drawing size as an index of depression and MMPI depression and MMPI depression scores in normal adults.


The use of clothing in human figure drawings.


Location and activity of the respiratory enzymes of baker's yeast and brewer's bottom yeast grown under anaerobic and aerobic conditions.


Type 3 diplococcus pneumonia in laboratory rats. An acute respiratory disease, due to Diplococcus pneumoniae type 3, affecting Wistar and Sprague-Dawley rats is described. The infection was experimentally transmitted to Sprague-Dawley rats. The zoonotic potential of the condition dictated euthanasia of affected animals and instigation of rigid sanitary measures.


Localized heat urticaria.

Localized heat urticaria.


Osteoporosis of the foot.

Osteoporosis of the foot.


Selective gonadal venography.

Selective gonadal venography.


Hemi-amputation of the left foot.

Hemi-amputation of the left foot.


Traumatic "cloven foot".

Traumatic "cloven foot".


Preferential hydrolysis of kynurenine peptides.


Radioprotective effect of 5-azacytidine in AKR mice.


Interaction of DNA with ribosomes in cell-free protein synthetizing systems of Chlorella pyrenoidosa.


Synergism between penicillins and lysozyme. Data which led to the synthesis of a new antibiotic salt: lysozyme ampicillinate. 3.


Glyceride fatty acid synthesis by liver homogenates of the developing rabbit.


The occurrence of catecholamines in the sea anemone.


The effect of p-methoxyphenylethylamine (PMPEA) on monosynaptic reflexes in the cat.


The actions of some cholinomimetic drugs on the isolated taenia of the guinea-pig caecum. 1. The actions on the taenia of 4-(m-chlorophenylcarbamoyloxy)-2-butynyl-trimethylammonium chloride (McN-A-343), N-benzyl-3-pyrrolidyl acetate methobromide (AHR-602), tetramethylammonium (TMA) and choline phenyl ether have been examined and compared with the actions of acetylcholine, nicotine and 1,1-dimethyl-4-phenylpiperazinium (DMPP).2. Responses of the taenia to these agonists are quantitatively and often qualitatively dependent on the tone of the preparation. A method is described which makes allowance for the effect of tone on heights of contractions.3. Acetylcholine, McN-A-343 and AHR-602 produced only contractions; TMA produced contractions or biphasic responses; and choline phenyl ether, nicotine and DMPP produced contractions, relaxations or biphasic responses.4. The mode of action of these compounds has been analysed by means of hyoscine, ganglion-blocking drugs, tetrodotoxin and local anaesthetics.5. It is concluded that acetylcholine, McN-A-343, AHR-602, TMA and choline phenyl ether act on muscarinic receptors in the smooth muscle. Choline phenyl ether has an additional action on nicotinic receptors of cholinergic neurones. Nicotine and DMPP act on nicotinic receptors of cholinergic neurones and of inhibitory neurones. An action on the latter is sometimes also seen with TMA and choline phenyl ether.6. With nicotine or DMPP, and TMA or choline phenyl ether in the presence of hyoscine, part of the contraction phase of biphasic responses (in which a contraction follows relaxation) is best explained as being triggered by the initial relaxation-that is, as a "rebound contraction".7. None of the compounds tested appeared to exert an atropine-sensitive action on neurones.8. In the presence of hyoscine high concentrations of agonists can act on sites not involved with lower concentrations.


Hyposensitization with bacterial vaccine in infectious asthma. A double-blind study and a longitudinal study.


The effect of electrical stimulation upon the accumulation of adenosine 3',5'-phosphate in isolated cerebral tissue.


Over-the-counter cough mixtures.

Over-the-counter cough mixtures.


Ferredoxin-NADP reductase from Pinus pinea.


Antiarrhythmic actions of clemizole as pharmacologic evidence for a circus movement mechanism in atrial flutter.


Immunochemistry of newly found substituents of polysaccharides of Rhizobium species. Acetyl and pyruvic acid groups were detected and estimated in the extracellular polysaccharides of Rhizobium trifolii and R. meliloti. Pyruvic acid was found also in the specific polysaccharide of pneumococcal type 27, and is believed to explain the cross-reactivity between antiserum to pneumococcal type 27 and these and other pyruvate-containing bacterial polysaccharides. Removal of pyruvate from a Rhizobium polysaccharide rendered it inactive with its homologous antiserum and with antiserum to pneumococcal type 27, but it then reacted with several antiserums to other pneumococcal types with which the intact material was unreactive.


Conservative treatment of ulcerative colitis: late results.


Hypotensive drugs. I.

Hypotensive drugs. I.


Antihistamine toxicity in children.

Antihistamine toxicity in children.


Pharmacological properties of AF 1161, a new psychotropic drug.


Observations on reovirus type 3 in certain culicine mosquitoes.


Arbovirus activity in southern Arizona. Isolations of virus and observations of sentinel chickens.


Inhibitors of the transhydrogenase activity of spinach ferredoxin-Nicotinamide adenine dinucleotide phosphate reductase.


Purification and properties of three separate menadione reductases from hog liver.


D-amino acid oxidase. IV. Inactivation by maleimides.


A requirement for lipids by the microsomal stearyl coenzyme A desaturase.


Psychological testing of cerebral malaria patients.


A tripartite model of ego functioning values and clinical and research applications.


Combined pharmacotherapy and psychotherapy.


Psychological adjustment and acute response to open heart surgery.


Notes on breeding and endophily of mosquitos in the "Shomron" district, Israel.


Complex formation between ferredoxin triphosphopyridine nucleotide reductase and electron transfer proteins.


Oxidation-reduction properties of flavodoxin from Peptostreptococcus elsdenii.


Residual eye movements in receptive-field studies of paralyzed cats.


Dermatitis medicamentosa.

Dermatitis medicamentosa.


Control of fatty acid synthesis in mitochondrial membranes.


Recent advances in the treatment of parkinsonism.


Electrical properties of the body wall of Hydra. If the hydrostatic pressure in the enteron of Hydra is made more than 2-4 mm of water greater than the outside pressure, the animal becomes distended, indicating that the normal enteron pressure is less than this. Positive enteron pressure attenuates the spontaneous, negative-going electrical spikes across the body wall, which are called contraction pulses (CP's) because of their relation to column contraction. Pressure has little effect on the transepithelial resting potential. The low frequency electrical impedance of the column is nonlinear. The impedance tends to increase as the transepithelial potential is made more negative. The nonlinearity has both initial and delayed components. The DC impedance of the column near the resting potential averages 100 kohms (approximately 5 kohms-cm(2)). The phase between transepithelial potential and imposed sinusoidal current approaches -90 degrees with increasing current frequency. Bode plots of the column impedance and the phase lag indicate that the column has three or more time constants. CP's show several unusual features: (a) their amplitude and frequency are essentially independent of the transepithelial potential when the latter is altered by imposed current; (b) there is practically no change in column impedance during CP firing; (c) when the transepithelial potential is clamped at zero, CP's continue to appear spontaneously as current spikes. These features are consistent with the hypothesis that the CP-generating membrane forms but a small fraction of the total transverse impedance of the column.


Religiosity, generalized anxiety, and apprehension concerning death.


Epilepsy.

Epilepsy.


Feasibility investigations of electrostatic precipitation for the removal of gaseous trace contaminants from manned cabin atmospheres. AMRL-TR-68-111.


Theoretical treatment of ohmic and rectifying properties of electrolyte filled micropipettes.


Current voltage measurements of electrolyte filled microelectrodes with ohmig and rectifying properties.


The nature and significance of invertebrate cartilages.


Motivation factors in persons seeking early diagnosis of cancer. A preliminary report.


Batch-feeding studies on high-solids activated sludge for treating concentrated human waste. SAM-TR-68-108.


A solar-illuminated algal photosynthetic exchanger. SAM-TR-68-66.


Effects of two antihistamine-containing compounds upon performance at three altitudes. AM 68-15.


Compendium of human responses to the aerospace environment. Volume 3. Sections 10-16. 12. Pressure. NASA CR-1205 (3).


Compendium of human responses to the aerospace environment. Volume 3. Sections 10-16. 10. Oxygen-CO2-energy. NASA CR-1205 (3).


Compendium of human responses to the aerospace environment. Volume 3. Sections 10-16. 11. Inert gas. NASA CR-1205 (3).


Compendium of human responses to the aerospace environment. Volume 3. Sections10-16. 13. Contaminants standards. NASA CR-1205 (3).


Compendium of human responses to the aerospace environment. Volume 3. Sections 10-16. 16. Anthropometry and temporo-spatial environment. NASA CR-1205 (3).


Compendium of human responses to the aerospace environment. 7. Acceleration NASA CR-1205 (2).


Synthesis and pharmacological activity of imidazo-(1,2-a)-pyridine-2-acetic and 2,3-dicarboxylic acid and related compounds.


On the hydroxylation of cyclohexane in rat liver microsomes.


Activity of repellents employed in aerosol form.


Synthesis and induction of tyrosine aminotransferase in synchronized hepatoma cells in culture. The generation cycle of an established line of rat hepatoma cells (HTC cells) was studied using synchronized cell techniques. Dexamethasone phosphate (Dex), a synthetic adrenal corticosteriod which induces tyrosine aminotransferase (TAT) in HTC cells randomly distributed in the cell generation cycle, did not affect the durations of the various phases of the cycle. The activities of TAT and several dehydrogenases, and the rates of general protein and RNA synthesis, were studied throughout the cycle.Dex, at 10(-5)M, when added to a synchronized cell population in the latter two thirds of G1 phase or anywhere in the S phase, induces TAT. During the period made up of G2, M, and early G1, Dex does not induce TAT. However, radioisotope incorporation into specifically immunoprecipitated TAT continues during mitosis, when general protein and RNA synthesis are decreased.


Glycerylphosphorylcholine diesterase: inhibition by nucelotides.


Amino acids and cerebral excitability.

Amino acids and cerebral excitability.


Spectrophotometric studies on aggregation of denatured DNA.


The effect of low body temperature on the intraparticulate hydrolysis of 131-I-albumin in toads.


Failure of dimethylsulfoxide to enhance experimental viral infection in laboratory animals.


Cooperation of enzymes responsible for polymerisation and methylation in pectin biosynthesis.


Studies on the mechanism of NAD-photoreduction by chromatophores of the facultative phototroph, Rhodopseudomonas capsulata.


Aromatic amino acid metabolism in the wabbler-lethal mouse.


Therapeutic use of gonadotrophins and clomiphene.


The proportion of two b locus allotypic determinants in rabbit antisera raised against pneumococcal polysaccharide SSS 3 antigen.


Immunochemical relationships of certain streptococcal group and type polysaccharides to pneumococcal capsular antigens.


Inhibition by non-steroidal anti-inflammatory agents of in vivo effects of "slow reacting substance C".


Circadian rhythm in mammalian body temperature entrained by cyclic pressure changes. A 24-hour cycle of pressure (1.0 to 1.09 atmospheres) can act as a zeitgeber to entrain the endogenous circadian rhythm of body temperature in pocket mice (Perognathus longimembris) under constant conditions of environmental temperature and light.


Interactions of the complement system with endotoxic lipopolysaccharide: the generation of an anaphylatoxin.


Attempt to isolate virus from mosquitoes during hemorrhagic fever in Calcutta.


Trauma rounds at the Montreal General Hospital. Case P6.


The inhibitory adrenergic receptors of the rabbit intestine.


One tablet dyspepsia study--pro-banthine.


Experimental frostbite. The effect of "double freeze" on tissue survival in the mouse foot.


Recurrent pneumonia. Predisposing illness and clinical patterns in 158 patients.


Slide histochemistry of enzyme activity in normal and atherosclerotic canine aorta.


Further evidence for charge transfer interaction in the purple complex of D-amino-acid oxidase.


An electrical method of measuring non-electrolyte permeability.


Patterns of non-electrolyte permeability.


Molecular forces governing non-electrolyte permeation through cell membranes.


Drug-induced lung disease.

Drug-induced lung disease.


Submitochondrial distribution of components of the steroid 11 beta-hydroxylase and cholesterol sidechain-cleaving enzyme systems in hog adrenal cortex.


Investigations on pantothenic acid and its related compounds. XX. Biochemical studies. 11. Enzymatic conversion of 2'-ketopantothenate to D-pantothenate in rat.


Studies on the mechanism of shock. The effect of catecholamines on the temperature response to injury in the rat.


The clinical appraisal of a new antihistamine Tavegyl in a dermatological practice.


High bay clean rooms.

High bay clean rooms.


Humoral transmission of hypertension: evidence from parabiosis.


3-beta-hydroxy-C24-steroid dehydrogenase in rat liver microsomes.


A nitrate reductase from Micrococcus denitrificans.


Further purification and properties of Neurospora nitrate reductase.


Uridine diphosphate glucose pyrophosphorylase in Dictyostelium discoideum. Stability and developmental fate.


Studies with specific enzyme inhibitors. XII. Resolution of DL-erythro-fluorocitric acid into optically active isomers.


A rapid method for detecting malformations in rat fetuses.


Temporal arteriography. A new technique for the investigation of giant cell arteritis and polymyalgia rheumatica.


Parents of schizophrenic, neurotic, asthmatic, and congenitally ill children. A comparative study.


The interaction of 6,6'-dithiodinicotinic acid with thiols and with ehrlich ascites tumor cells.


Response differences in some steroid-sensitive hepatic enzymes in the fasting rat.


Oxidative degradation of diazinon by rat liver microsomes.


Effect of histamine and antihistaminics on central vasomotor loci.


An experimental gastric ulcer of the rat produced with anticholinergic drugs under stress.


Effect of tranylcypromine on the mechanical activity of rabbit aorta and esophagus and guinea pig taenia coli.


Changes in personality and subjective experience associated with the chronic administration and withdrawal of opiates.


The influence of ethanol on auditory signal detection.


Plasma adenosine deaminase activity in children with rheumatic fever and rheumatoid arthritis.


MMPI changes in alcoholics during hospitalization.


Induction of emesis by detergent ingredients and formulations.


A comparison of the pharmacological activities of tertiary bases and their quaternary ammonium derivatives.


Activity of antihistamines in laboratory antidepressant tests.


Actions of a new antihypnic drug (Cylert) upon the sleep and wakefulness neuronal systems.


The effect of exogenous human chorionic gonadotrophin on steroid excretion in the newborn.


Psychiatric dialogue between East and West.


An exploratory study in the treatment of homosexuality by combining principles from psychoanalytical theory and conditioning: theoretical and methodological considerations.


Obsessional traits, obsessional symptoms and anal erotism.


Effects of aldosterone on blood pressure and glucose-6-phosphate dehydrogenase activity of heart muscle.


Studies on the cardiotoxicity of ouabain.


The effect of muscle activity factor (MAF) on cardiac contractility and sugar transport.


Parental relations and male homosexuality in patient and nonpatient samples.


Hippocampal field potentials: their in- teraction and their relation to hippocampal output.


Personality characteristics of male transvestites. 3.


Bacterial oxidation of dimethylamine, a new mono-oxygenase reaction.


The absolute configurations of the pheniramines, methyl phenidates, and pipradrols.


Antimicrobial activity of a series of aminoalkyl esters of benzyldithiocarbamic acids.


Caries-inhibiting effect of fluoride tablets.


Towards a completely computerized record system.


A new anthranilic acid hydroxylase from Aspergillus niger. Purification and properties.


Prevention of cyclic and triton-induced increases in hydroxymethylglutaryl coenzyme A reductase and sterol synthesis by puromycin.


Allosteric inhibition of a triphosphopyridine nucleotide-specific isocitrate dehydrogenase from Crithidia fasciculata by nucleoside triphosphates.


Heterogeneous distribution of enzymes in submicrosomal membrane fragments. Microsomal membranes are postulated to contain either a homogeneous arrangement of individual enzymes or groupings of functionally related enzymes. In the present study we attempt to distinguish between these hypotheses in subfractions of rough microsomes from rat liver. After sonication, the individual vesicles that make up the rough-membrane fraction average less than 1/100 of their previous mass. The vesicles in the sonicated suspension are fractionated roughly according to size on a continuous sucrose gradient. Enzyme activity or concentration in fractions of the gradient is expressed on a phospholipid basis. Fractions containing primarily small vesicles differ from those containing larger vesicles in a manner suggesting a certain degree of separation of NADH-linked from NADPH-linked enzymes. NADH-ferricyanide reductase, NADH-cytochrome c reductase and cytochrome b(5) are most concentrated within the large vesicles in the lowest third of the gradient. In contrast, NADPH-cytochrome c reductase and cytochrome P-450 are found in highest concentration in the small vesicles that make up the upper third of the gradient. The results suggest a nonrandom distribution of these two enzyme groups in the membranes of the endoplasmic reticulum.


The synthesis and turnover of rat liver peroxisomes. I. Fractionation of peroxisome proteins. Rat liver peroxisomes isolated by density gradient centrifugation were disrupted at pH 9, and subdivided into a soluble fraction containing 90% of their total proteins and virtually all of their catalase, D-amino acid oxidase, L-alpha-hydroxy acid oxidase and isocitrate dehydrogenase activities, and a core fraction containing urate oxidase and 10% of the total proteins. The soluble proteins were chromatographed on Sephadex G-200, diethylaminoethyl (DEAE)-cellulose, hydroxylapatite, and sulfoethyl (SE)-Sephadex. None of these methods provided complete separation of the protein components, but these could be distributed into peaks in which the specific activities of different enzymes were substantially increased. Catalase, D-amino acid oxidase, and L-alpha-hydroxy acid oxidase contribute a maximum of 16, 2, and 4%, respectively, of the protein of the peroxisome. The contribution of isocitrate dehydrogenase could be as much as 25%, but is probably much less. After dissolution of the cores at pH 11 , no separation between their urate oxidase activity and their protein was achieved by Sephadex G-200 chromatography.


Antibody to dihydrofolate reductase from a methotrexate-resistant subline of the L1210 lymphoma.


Nine-month-old infant with fever, rash, and pneumonitis.


Medical management of parkinsonian syndrome.


Behaviour of tick-borne encephalitis virus in artificially infected Ixodes persulcatus ticks.


Arbovirus haemagglutinin: inactivation by high pressures.


Interference between Coxiella burneti and cytopathic viruses in chick embryo cell cultures. I. Establishment of the interference.


Experimental respiratory infection induced by rabies virus variants adapted to tissue culture.


Two strains of rickettsiae of Rocky Mountain spotted fever group recovered from Dermacentor marginatus ticks in Czechoslovakia. Results of preliminary serological identification.


Localization of a PR8 influenza virus antigens in tissues and organs of mice infected intraperitoneally and intravenously.


Studies on the inheritance of the susceptibility to poliovirus of phytohaemagglutinin-transformed macrophages.


Fluorescent antibody study of vaccinia virus propagation in chick embryo chorioallantoic membrane.


Haemagglutinating activity of variola virus.


Comparative titrations of street rabies virus according to the cytopathic effect and by immunofluorescence in tissue cultures and in mice.


Comparison of dental caries prevalence in three cities.


The effectiveness of fasting in the treatment of superobesity.


International Cell Research Organization.


Effects on alpha-mannosidase on the active site of Japanese encephalitis viral receptor.


Viraemia of polecats (Putorius putorius) after infection with tick-borne encephalitis (TE) virus by ticks.


Vaccinia virus peritoneal infection in rats of different ages.


Behavioural patterns of tick-borne encephalitis virus variants in human nervous cells in vitro.


Uniformity of structural characteristics throughout the length of skeletal muscle fibers.


Ig-allotype-anti-Ig-allotype reaction in rabbit skin.


Multivariate analysis of clinical rating profiles of suicidal psychiatric inpatients.


DAP correlates of Sc scores on the MMPI.


SPI and MMPI predictors of psychopathology.


Comparative diagnostic judgments from the Rorschach and the MMPI.


On the specificity of lectins with a broad agglutination spectrum. I. The nature of the specific receptors for Ricinus communis and Solanum tuberosum Lectins.


A critical evaluation of three methods for the study of adrenergic beta-blocking and anti-arrhythmic agents.


An investigation of antihistaminic activity and gastric ulceration.


Psychophysical studies of physiological fatigue criteria.


A national medical forum.

A national medical forum.


Presence and properties of dihydrofolate reductases within the genus Crithidia.


Recent advances in the treatment of acute leukemia in children.


The president's page.

The president's page.


Large kidney tumor.

Large kidney tumor.


Resuscitation and treatment following submersion.


The Klinikum.

The Klinikum.


Some medical editors I have known.

Some medical editors I have known.


Ragweed hayfever and asthma.

Ragweed hayfever and asthma.


Use of combined furazolidone and tetracycline in controlling institutional shigellosis.


Should food iron be increased.

Should food iron be increased.


Rx to check child molesting.

Rx to check child molesting.


Studies on vector susceptibility and larval morphology of a filaria of the slow loris, Nycticebus coucang.


A meth for extracting mosquito eggs from soil samples taken from oviposition sites.


Studies on arboviruses and bats (Chiroptera) in East Africa. II. Isolation and haemagglutination-inhibition studies on bats collected in Kenya and throughout Uganda.


Toothbrushing frequency and its relationship to dental caries and periodontal disease.


Pyridine coenzymes. 8. Autoxidation of the reduced form catalyzed by 4-amino-2,6-diiodophenol.


A souble 17 beta-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids.


Adrenal cells in tissue culture. 3. Effect of adrenocorticotropin and 3',5'-cyclic adenosine monophosphate on 11 beta-hydroxylase and other steroidogenic enzymes.


Progress in otorhinolaryngology.

Progress in otorhinolaryngology.


Snake bite.

Snake bite.


Gynecologic profile of the late teenager.


Right pneumonectomy complicated by cardiac arrest in pregnancy.


Challenges facing regulators and regulatees.


Survey of visiting privileges for pediatric patients in hospitals.


Crisis in child care.

Crisis in child care.


Illinois Department of Public Aid payment procedures and policies explained.


Five South American medical school libraries.


The story of public health in Illinois.

The story of public health in Illinois.


Investigations on the interactions between poliovirus RNA and the host cell under the influence of some salt solutions.


The character of interactions of antibodies and inhibitors with influenza virus.


Experimental inhalation infection of laboratory rodents with rabies virus.


Development of inhalation rabies infection in suckling guinea pigs.


Effects of gamma radiation on Western equine encephalomyelitis and tick-borne encephalitis viruses.


Venezuelan equine encephalomyelitis virus: determination of inhalation LD50 for guinea pigs and mice.


Study of plaque titration of vaccinia virus in chick embryo cell cultures. I. Assays under an agar overlay.


Serological properties of certain isolates of red clover necrotic mosaic virus.


Interference between Coxiella burneti and cytopathic viruses in chick embryo cell cultures. II. An attempt to elucidate the mechanism of the interference.


Plaque formation by adenovirus 7 in human diploid cell strains.


Effect of reagents affecting specific groups of proteins on the haemagglutinating activity of rubella virus.


Purification and concentration of parainfluenza virus.


The inhibitory activity of some plant juices on the infectivity of watermelon mosaic virus.


Some properties of red clover necrotic mosaic virus.


Pathological mitoses in cultures of human embryo fibroblasts infected with cytomegalovirus.


Prevailing forms of pathological mitoses in type 1 adenovirus-infected cultures of RES (clone 1) cells.


The use of Hyalomma dromedarii tick tissue cultures for the isolation of tick-borne encephalitis virus from its natural foci.


Augmenters and reducers: a note on a replication failure.


Liver pyridine nucleotides, lactate, and pyruvate in hyperthermic rats.


Microbiological and pharmacological behavior of 7-chlorolincomycin. Replacement of the 7-(R) hydroxyl group of lincomycin by a 7-chloro-substituent produced a compound with greater in vitro activity than the parent. Laboratory studies of this compound showed it to be highly active against all of the following strains of gram-positive organisms examined, including penicillinase- and nonpenicillinase-producing staphylococci, Diplococcus pneumoniae, Streptococcus viridans and Streptococcus pyogenes. The enterococci, as well as all the gram-negative organisms tested, with the exception of some strains of Haemophilus, were uniformly insensitive to this agent. The activity of 7-chlorolincomycin was not affected by serum or inoculum size. Resistance developed in a slow stepwise pattern. Peak levels of approximately 2 mug/ml were achieved in the serum of volunteers after ingestion of 150 mg either in the fasting state or after a meal. No untoward effects were noted. The antibiotic appears to be of potential value in the treatment of infections due to gram-positive organisms, with the exception of enterococcus.


Renal substrates and effect of lipokinetic arylamines on third-factor sodium excretion.


Effects of psychodysleptic drug psilocybin on visual perception. Changes in brightness preference.


Chymotrypsin-like proteases from the sea anemone, Metridium senile.


Sustained oscillations in a lactoperoxidase. NADPH and O2 system.


Efficacy of therapeutic drugs for vertigo.


Auto-immunity and the central nervous system.


Possible role of dopamine as transmitter to promote discharge of LH-releasing factor.


Effect of diethylstilbestrol on enzymes of cryptochid mouse testes of Balb-c mice.


An involvement of St 155 [2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, catapres] in cholinergic mechanisms.


Young drug addicts: background and personality.


The dangers of therapeutic agents used in the treatment of asthma.


Allergic reaction to insect stings.

Allergic reaction to insect stings.


24- and 48-hour cycles of malaria parasites in the blood; their purpose, production and control.


Study of the effect of cabin environment on insensible water loss.


Evolution of epinephrine responses of hypoxic rabbit aortic muscle.


Virus isolation and serological studies of arthropod-borne virus infections in a high rainfall area of North Queensland.


Metabolic response of rat brain to acute hypoxia: influence of polycythemia and hypercapnia.


Fat metabolism and chronic acceleration.


Automated fluorometric determination of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activities in red blood cells.


Studies on immunological paralysis. II. The detection and significance of antibod-forming cells in the spleen during immunological paralysis with type 3 pneumococcal polysaccharide.


Effectiveness of an acidulated phosphate fluoride-pumice prophylactic paste: a two-year report.


Erythrocyte metabolism in the bottle-nosed dolphin, Tursiops truncatus.


A simplified and sensitive method for citrate determination in biological samples.


Studies on immunological paralysis. I. A consideration of macrophage involvement in the induction of paralysis and immunity by type II pneumococcal polysaccharide.


The repression-sensitization scale: effects of several variables and two methods of obtaining scores.


A comparison of psychiatric diagnosis and behavioral classification as criteria for differentiating psychiatric patients.


Alcohol dehydrogenase of retina: substrate specificity and some other properties.


The factorial structure of the Minnesota Multiphasic Personality Inventory from an aged sample.


Bacterial resistance to penicillins and cephalosporins.


Central muscle relaxant properties of 2,6-dimethylphenethylurea and related compounds.


A screening method for vasodilator drugs.


The use of the in vivo trachea preparation of the guinea-pig to asses drug action on lung.


Effect of diazepam and chlordiazepoxide on the metabolism of other drugs.


Effect of nialamide and methyldopa on the analgesic action of morphine in rats and mice.


Resistance to tetrodotoxin in toad sympathetic nerves.


On the cumulation of digitoxin and digitoxigenin in isolated heart muscle preparations.


Non-spherical emulsion particles.

Non-spherical emulsion particles.


Potentiation of the actions of pentobarbitone by nikethamide.


A model for evaluation of thiazide-induced hypotension.


Evidence for a cholinergic mechanism in brain involved in the tetrabenazine reversal by thymoleptic drugs.


Inhibition of nucleic acid polymerases by salicylate in vitro.


Response of aequorin bioluminescence to rapid changes in calcium concentration.


Transformation and DNA size: two controlling parameters and the efficiency of the single strand intermediate.


Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.


Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.


Effects of extracorporeal circulation on personality and cerebration.


Evidence for the hepatic metabolism of some monoalkylhydrazines.


Photoreduction of ferredoxin and its use in NAD(P)+ reduction by a subcellular preparation from the photosynthetic bacterium, Chlorobium thiosulfatophilum.


Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors.


Corticosteroidogenesis and cytochrome levels in the regenerating rat adrenal.


Site-specific inactivation of the photophosphorylation reactions of Anabeana variabilis.


Oxidative enzyme components of avian liver microsomes. Changes during embryonic development and the effects of phenobarbital administration.


Antihypertensive agents. II. Synthesis and hypotensive activity of certain 1,4,5-trisubstituted pyrazoles.


Personality and social class factors associated with occupational disability in patients with chronic obstructive lung disease. An exploratory study.


Effects of opiates and opiate antagonists on the Straub tail reaction in mice. 1. Subcutaneous injections of opiates produced the Straub tail reaction in mice. The potencies of the opiates in mice were consistent with previous estimates of the analgesic potencies in animals and in man.2. The potencies of sixteen antagonists in counteracting the reaction were consistent with those previously obtained with the rat tail-flick test.3. The (-) isomers of four benzomorphan derivatives were much more potent in counteracting the reaction than their (+) isomers and about twice as potent as their racemates. The activity of the isomers seemed to follow Pfeiffer's rule: the lower the effective dose of a drug, the greater the difference in the pharmacological effects of the optical isomers. One of the trans isomers acted like an opiate, while its cis isomer acted like an antagonist.4. Naloxone and nalorphine fulfilled conventional criteria for competitive antagonism, whereas atropine and the (-) and the (+) isomers of pentazocine and of cyclazocine did not do so.5. The Straub tail test seems to be useful for studying structure-activity relations among opiates and opiate antagonists.


Studies on the action of acetylcholine on the sino-auricular node of the dog. 1. The response of the sino-auricular node to direct injection of acetylcholine in the artery supplying the node has been studied in the dog.2. Acetylcholine in graded doses (2, 5, 10 mug) caused acceleration of the sinus rhythm.3. The time course of the positive chronotropic action of acetylcholine resembled that produced by adrenaline or noradrenaline.4. The positive chronotropic action produced by acetylcholine was blocked by dichloro-isopropylnoradrenaline and pronethalol and potentiated by cocaine.5. In reserpinized dogs, acetylcholine in similar doses produced sinus bradycardia. The positive chronotropic response could be temporarily restored by infusion of adrenaline or noradrenaline.6. Atropine blocked both the positive and negative chronotropic actions of acetylcholine.


Dental disease in the mentally handicapped.


Some findings on the endonuclease of pneumococci.


Role of catecholamines in centrogenic cardiac arrhythmia induced by aconitine. 1. Injection of 20 mug of aconitine into the lateral ventricle of dogs anaesthetized with pentobarbitone regularly induced cardiac irregularities and hypertension. The cardiovascular changes appeared within 5 min and lasted for about 90 min. Tachyphylaxis to the aconitine-induced cardiovascular effects was observed.2. The aconitine-induced arrhythmia and hypertension were centrogenic, for they were abolished or prevented by spinal transection (C(2)) or ganglionic blockade.3. Bilateral vagotomy as well as bilateral stellate ganglionectomy merely raised the threshold for arrhythmia without affecting the blood pressure response. The neural supply to the heart, therefore, does not seem to be the major pathway concerned in the genesis of the centrogenic cardiovascular effects of aconitine.4. The centrally evoked release of endogenous catecholamines from the adrenal glands was responsible for the aconitine-induced arrhythmia, since the arrhythmia could be blocked or prevented by prior reserpinization, bilateral adrenalectomy or thoracic splanchnic nerve section.5. alpha- and beta-adrenoceptive receptor blocking agents prevented or abolished the aconitine-induced arrhythmia in a manner similar to the catecholamine-induced arrhythmia.


Three years of supervised toothbrushing with a fluoride-phosphate solution.


A survey of caries-experience among the preschool children of Philadelphia.


Report on the American Dental Association's Conference on the Clinical Testing of Cariostatic Agents.


Results of the City of Milwaukee dental surveys--1950; 1959; 1965.


Report on the 1969 Ohio Conference on Dental Care and Dental Health Education.


Beta-adrenergic blocking agents. IV. Variation of the 2-naphthyl group of pronethalol (2-isopropylamino-1-(2-naphthyl)ethanol).


Rehabilitation following myocardial infarction.


Acute anuria due to polyarteritis nodosa.


The synthesis and properties of phosphopyridoxyl amino acids.


The regulation of tyrosine aminotransferase in Tetrahymena pyriformis.


Regulatory roles of cyclic 3',5'-AMP in bacteria: control of malic enzyme of Escherichia coli.


The sequential stimulation of uracil-rich and guanine-rich RNA species during cortisone induction of hepatic enzymes.


Metabolism of tyramine-3H and octopamine-3H by rat brain.


Unstable binary capsulated transformants in pneumococcus. Through transformation reactions, binary capsulated SI-III strains of pneumococci have been isolated that are unstable and lose the SI capsular genome at high frequency. The instability is caused by the specific mutation in the SIII capsular genome common to all of the unstable strains. In the family of strains studied, the SI capsular genome was integrated into the recipient chromosome in at least two loci: one apparently adjacent to the resident capsular genome and a second some distance from it. A hypothesis is presented to explain the instability of the strains on the basis of redundancy of genetic information.


Steady-state concentrations of glucose-6-phosphate, 6-phosphogluconate, and reduced nicotinamide adenine dinucleotide phosphate in strains of Escherichia coli sensitive and resistant to catabolite repression. No correlation was found between the cellular steady-state concentrations of glucose-6-phosphate, 6-phosphogluconate, and reduced nicotinamide dinucleotide phosphate and resistance versus sensitivity to catabolite repression.


Some properties of the microsomal system metabolizing DDT in Triatoma infestans.


Blocking of pentose phosphate pathway in the brain of rats by 6-aminonicotinamide.


Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application.


Essential pharmacology.

Essential pharmacology.


Ganglionic transmission.

Ganglionic transmission.


Gentamicin in pediatric infections caused by gram-negative organisms.


EEG and human psychopharmacology.

EEG and human psychopharmacology.


Laboratory evaluation of erythromycin in a general hospital.


Malaria parasites of Brazilian monkeys.

Malaria parasites of Brazilian monkeys.


Studies on the life cycle of a filaria of the slow loris, Nycticebus coucang.


Consideration of gentamicin for therapy of neonatal sepsis.


The life cycle of Romanomermis sp. (Nematoda: Mermithidae) a parasite of mosquitoes.


Recent experimental research on avian malaria.


Effect of 2-oxoglutarate on the catalytic activity and stability of glutamate dehydrogenase.


Malate dehydrogenase (decarboxylating) (NADP) isoenzymes of Opuntia stem tissue. Mitochondrial, chloroplast, and soluble forms.


Electron-nuclear double resonance from flavin free radicals in NADPH dehydrogenase ("old yellow enzyme").


The court study unit: patient characteristics and differences between patients judged competent and incompetent.


Objective measurement of an hypnotically induced simulation of psychopathology.


Comparison of emotion profiles as defined by two additional MMPI profile types in ale narcotic addicts.


Introversion, extraversion, and social intelligence: a replication.


The MacAndrew alcoholism scale: a replication.


An attempt to develop a useful process-reactive scale for the MMPI.


Comparability of two methods of administering the MMPI to brain-damaged geriatric patients.


Senility or garden-variety maladjustment?


Comments on mosquito and gnat research activities at Berkeley.


Work at Berkeley on feeding behavior and nutrition of mosquitoes.


The University of California mosquito research program at Fresno.


Ego control patterns and hostility expression: correlation or tautology?


Myasthenia gravis: psychiatric concomitants.


Report on the third bi-annual MAG conference on medical education.


Student input in medical education: an educator's report.


Student input in medical education: a student view.


Butaperazine (Repoise).

Butaperazine (Repoise).


Zoanthid sterols.

Zoanthid sterols.


The monoamine oxidase catalyzed degradation of phenelzine-l-14C, an irreversible inhibitor of monoamine oxidase--I. Studies in vitro.


Spironolactone actions, independent of mineralocorticoid blockade.


Aldrin epoxidase activity of rat liver and rat liver microsomes under various conditions of storage.


The pharmacology of sheep tracheobronchial muscle: a relaxant effect of histamine on the isolated bronchi. 1. Histamine contracted the tracheal and major bronchial muscles of sheep and relaxed the muscles of the lesser bronchi and bronchioles.2. The stimulant action of histamine on the trachea was antagonized by mepyramine, whereas the relaxant effect on the bronchial tree was not.3. 5-Hydroxytryptamine contracted the musculature from all parts of the respiratory tract-an effect which was specifically antagonized by both methysergide and atropine.4. Acetylcholine contracted all sheep tracheobronchial muscle and isoprenaline relaxed it.5. Bradykinin had a very weak stimulant action.6. It is concluded that histamine relaxes sheep bronchi by a direct excitation of histamine-sensitive receptors which are not blocked by mepyramine. No indirect components through autonomic nervous elements or by way of catecholamine release were evident. 5-Hydroxytryptamine seemed to have a dual mode of action in contracting sheep tracheobronchial muscle (a) directly on its own receptors and (b) indirectly through parasympathetic components.


Effects of quaternary ammonium compounds on choline transport in red cells. 1. Neuromuscular blocking agents have been shown to be powerful inhibitors of choline transport in human erythrocytes. Ganglionic blocking agents were weaker inhibitors.2. The affinity of the choline transport site for alkyltrimethylammonium compounds was considerably higher than its affinity for alkyl-bis-(trimethylammonium) compounds of similar chain length. The affinity increases with increasing length of the alkyl chain in both series.3. Tetramethylammonium (TMA), ethyl- and propyltrimethylammonium appear to enter the cells on the choline carrier while the larger monoquaternary compounds, and the bisquaternary compounds, bind to the carrier but are unable to cross the cell membrane.4. Radioactively labelled carbachol, acetylcholine and decamethonium do not enter the cells on the choline carrier.5. Choline transport in erythrocytes from patients with myasthenia gravis is normal, suggesting that this disorder is not associated with a generalized defect of choline transport.


Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle. 1. Mesenteric arteries immersed in a depolarizing solution contract in the presence of calcium. These contractions are proportional to the calcium concentration and are reversible.2. Mesenteric arteries immersed in a calcium-free depolarizing solution contract in the presence of adrenaline. Under the experimental conditions reported here, this response develops only about one-third of the contractile tension developed in polarizing solution (modified Krebs bicarbonate).3. Cinnarizine and chlorpromazine inhibit the contractile response to calcium and induce relaxation of depolarized muscle previously contracted by calcium; cinnarizine was 4 times more potent than chlorpromazine in such activity.4. Chlorpromazine inhibits the response to adrenaline in both polarizing and calcium-free depolarizing solutions, whereas cinnarizine inhibits the response in polarizing solution but not that in calcium-free depolarizing solution.5. The significance of these results is discussed.


Reversal by pronethalol of dibenamine blockade: a study on the seminal vesicle of the guinea-pig. 1. The guinea-pig seminal vesicle has been shown to be a very suitable test object for the study of mechanisms involving alpha-adrenoceptive receptors, because no beta-receptors were found in this preparation.2. Adrenaline, noradrenaline and phenylephrine were directly acting agonists, their ED50 values being 7.1 x 10(-6)M, 1.5 x 10(-5)M and 2.7 x 10(-5)M, respectively.3. Pretreatment with reserpine had no influence on the contractions caused by adrenaline, noradrenaline and phenylephrine but abolished or greatly reduced the contractions caused by dopamine. Cocaine enhanced the effects of adrenaline, noradrenaline and phenylephrine and reduced those of dopamine.4. Pronethalol (6.8 x 10(-5)M) reversed the alpha-receptor blockade by dibenamine, ergotamine and phentolamine of responses to adrenaline, noradrenaline and phenylephrine; it did not affect the blockade by dibenamine of responses to histamine.5. Reversal of the blockade by dibenamine was observed only when its concentration was such that it caused a parallel shift of the dose-effect curves of the agonists to the right; higher concentrations, which caused an unsurmountable depression of the maximal contraction, were not antagonized by pronethalol.6. It is assumed that the reversal is dependent on a direct action on alpha-receptors, "spare receptors" being probably involved.


The role of the sympathetic nervous system in the cardiovascular responses to angiotensin in the pithed rat. 1. Angiotensin (200-500 ng, intravenously) produced a biphasic pressor response accompanied by reflex bradycardia in rats anaesthetized with sodium pentobarbitone. In pithed rats and in anaesthetized animals treated with a ganglion blocking agent there was a similar pressor response but an increase in the heart rate which was coincident with the second phase of the pressor response. In pithed preparations an increase in cardiac contractile force accompanied the heart rate changes.2. Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat. Propranolol abolished the chronotropic and inotropic action of angiotensin, but left the biphasic pressor response unaltered. Bethanidine, or pretreatment with reserpine, altered the pressor response to a simple rise, and also abolished the chronotropic action of angiotensin. Phentolamine also abolished the second pressor component. Desmethylimipramine produced a marked potentiation of the cardiovascular effects of angiotensin at all dose levels tested (10-500 ng).3. It is concluded that in the rat only large doses of angiotensin are capable of indirectly stimulating the sympathetic nerves either at the site of their ganglionic cells or their post-ganglionic nerve ending.


The action of certain haloalkylamines on some biological activities of bradykinin. 1. Bradykinin and histamine reduced the blood pressure in normotensive anaesthetized rabbits. They produced a pressor or biphasic response when the initial arterial pressure was lowered by acute haemorrhagic shock or mecamylamine blockade. When blood pressure was lowered by pretreatment with reserpine, bradykinin remained depressor and histamine produced a biphasic response.2. Phenoxybenzamine abolished the pressor responses to bradykinin and histamine, but potentiated and prolonged the depressor response to bradykinin.3. Phenoxybenzamine-OH and SY28-OH modified neither the pressor nor depressor responses to histamine, nor the pressor response to bradykinin. However, they greatly potentiated and prolonged the hypotensive effect of bradykinin.4. In the isolated rabbit ear preparation, the initial vascular tone influenced the responses to bradykinin and histamine. In preparations having low vascular tone they were vasoconstrictors, but when the tone was raised by angiotensin or noradrenaline, they were vasodilators.5. Phenoxybenzamine blocked the vasconstrictor effect of bradykinin in a rabbit ear preparation having low vascular tone and phenoxybenzamine or its related ethanolamine potentiated the vasodilator response to bradykinin in preparations in which the tone was high.6. The significance of these findings is discussed.


Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.


Nucleic acid labelling of experimentally-induced cryptorchid rat testis.


Periarteritis nodosa associated with salt-losing nephritis.


The role of DHA in the pathogenesis of obesity and its metabolic complications.


Prolonged gestation in the rat and its usefulness in experimental teratology.


Ion movements in red cells treated with propranolol.


Acid phosphatase activity in palates of developing normal and chlorcyclizine treated rodents.


Decayed, missing and filled teeth in British adult populations.


Transfer of Hepatozoon rarefaciens (Sambon and Seligmann, 1907) from the indigo snake to a gopher snake by a mosquito vector.


Gastrin inhibition of gastric secretion before and after portacaval shunt.


Pharmacological properties of bendazac (AF 983) with particular reference to its topical action on some experimental inflammatory processes.


The open and closed mind: a review of dogmatism.


Effectiveness of space crew performance subsequent to sudden sleep arousal.


Recovery of potable water from human urine.


Selection of gravitational environment by locomotion in fields of acceleration.


Prediction of the final volume of the human body exposed to a vacuum.


Status report on space medicine in the United States.


Alpha1-antitrypsin deficiency, emphysema, necrotizing angiitis and glomerulonephritis.


Pyridine nucleotides in human erythrocytes in different metabolic states.


The reductive decomposition of organic mercurials by cell-free extract of a mercury-resistant pseudomonad.


H2O2 prodution during NADPH oxidation by the granule fraction of phagocytosing polymorphonuclear leucocytes.


Studies on the biosynthesis of 5-methoxytryptophol in the pineal.


The role of hydrogen peroxide and glutathione in glucose oxidation by the thyroid.


Extraversion, emotionality, and physiological response to relaxation training and hypnotic suggestion.


Development of an empathy scale.

Development of an empathy scale.


Sensing humor: latency and amplitude of response related to MMPI profiles.


Driver accidents and the neuropsychiatric patient.


Follow-up of the later careers and lives of 1,000 boys who dropped out of high school.


Treatment of allergic rhinitis.

Treatment of allergic rhinitis.


Enzymic epimerization of sequoyitol to D-pinitol in Trifolium incarnatum.


The anamnestic antibody response to type 3 specific pneumococcal polysaccharide. Rabbits immunized with killed type III pneumococci respond to anamnestic challenge by type specific polysaccharide (S III) with the synthesis of anti-S III antibody if a long interval is allowed to elapse between primary and secondary immunization. A study of the anti-S III antibody produced early and late in the immune response revealed no change in molecular class, banding pattern of dissociated light chains, or S III binding characteristics as measured under equilibrium conditions or by study of dissociation kinetics utilizing radioiodinated p-OH-benzyl-S III. Sequential booster injections of S III into rabbits primarily immunized with whole organisms 8 or 9 months earlier led to a progressive decrease in the number of animals showing successful anamnestic responses and in the magnitude of those responses. It is concluded that S III depletes the antigen sensitive cell population in the secondary response largely because of its limited ability to stimulate sustained proliferation by such cells.


Early effects of cadmium and zinc on testis and body temperatures.


Stimulation of oxygen uptake by trenimon in isolated rat thymocytes.


The evaluation of central nervous system stimulants in a new laboratory test for antidepressants.


Selfaggressiveness: a new type of behavioral change induced by pemoline.


The problem of cytoplasmic integration.

The problem of cytoplasmic integration.


Fine structure of cytoplasm in relation to synthesis and secretion in plant cells.


General introduction to cytoplasm.

General introduction to cytoplasm.


The flagellar apparatus as a model organelle for the study of growth and morphopoiesis. With an appendix. Temperature control apparatus used in flagellar regeneration experiments.


Studies on flagella-less, stumpy, and short flagellum mutants of Chlamydomonas reinhardii.


The ultrastructure of mitochondria.

The ultrastructure of mitochondria.


Biochemistry of Chlamydomonas flagella.

Biochemistry of Chlamydomonas flagella.


Uptake of biologically active substances by lysosomes.


The peroxisome: a new cytoplasmic organelle.


The influence of the cytoplasm on the nucleus during cell differentiation, with special reference to RNA synthesis during amphibian cleavage.


Ethanol-induced artifacts in the metabolism of 3H-vitamin D3.


The digestive function of lysosomes as studies by the turnover of ingested foreign macromolecules.


Prevention of experimental allergic encephalomyelitis by combination of epinephrine and a phenothiazine derivative, propiomazine.


Rapid electrophoretic examination of diaphorases in Mycobacterium tuberculosis.


A simplified method for determination of nicotinamide-adenine dinucleotides in liver tissue.


A case of so-called demyelinating encephalitis.


Reconstructive surgery in lesions of the foot.


Stimulation of the processes of somatic embryogenesis in some porifera and coelenterata. II. Provocation of somatic embryogenesis in Laomedea flexuosa hinks by colchicine and mechanical injuries.


Dental caries in children related to availability of sweets at school canteens.


Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.


New light on how aspirin works.

New light on how aspirin works.


Isolation and purification of human erythrocyte glucose-6-phosphate dehydrogenase from small amounts of blood.


A new determination of oxidized and reduced nicotinamide-adenine dinucleotide in tissues.


Case report. Bilateral sertoli cell tumour in a canine cryptorchid with accompanying pathological lesions.


Purification and regulatory properties of the biosynthetic L-glycerol 3-phosphate dehydrogenase from Escherichia coli.


Protection of cattle against experimentally induced anaphylaxis.


Recent developments in the chemistry of nitrogen fixation.


Progress in the biochemistry of nitrogen fixation.


Special aspects of nitrogen fixation by blue-green algae.


Biological and ecological aspects of nitrogen fixation by free-living micro-organisms.


Nitrogen fixation in legume root nodules: biochemical studies with soybean.


Genetics of symbiosis and nitrogen fixation in legumes.


Stimulation of the process of somatic embryogenesis in some porifera and coelenterata. I. Effect of cancerogenic agents on some porifera.


Psychological factors related to spontaneous and therapeutic abortion.


Recent trends in cancer biochemistry: the importance of studies on fetal tissue.


Purification and properties of a DPNH-TPNH diaphorase from Clostridium kluyverii.


Histochemical study of endometrial carcinoma. Systemic investigations of enzymes in infiltrating regions of tumors and interrelations with infiltrated connective tissue.


Inflammation in healing. 1. Time-course and mediation of exudation in wound healing in the rat.


Effects of hypophysectomy and ACTH administration on the level of adrenal cholesterol side-chain desmolase.


Comparison of two methods for the bioassay of oxytocin.


Division of isolated furrows and furrow fragments in invertebrate eggs.


Beta-adrenergic blocking agents. VI. Pronethalol and propranolol analogs with alkyl substituents in the alkanol side chain.


The Croonian Lecture, 1968. The haemoglobin molecule.


Effects of selection and migration on geotactic and phototactic behaviour of Drosophila. II.


Concurrent regulation of two enzymes in fungi.


The Ferrier lecture, 1968. Motor apparatus of the baboon's hand.


Caries experience of five-year-old children from fluoride and non-fluoride communities.


Patterns of tooth loss in British populations. Studies on National Health Service patients.


On the positional specificity of phospholipase A of certain species of mosquitoes.


Of spirit, for strength.

Of spirit, for strength.


Mucopurulent conjunctivitis and Hemophilus.


Soluble and mitochondrial forms of tyrosine aminotransferase. Relationship to human tyrosinemia.


The equilibrium reaction sorbitol--fructose in the intact mosquito.


NADP specific dehydrogenases and hepatic lipogenesis in the hibernator.


Substances modifying the cardiac cholinergic excitation in Tapes watlingi.


A new psychotropic agent. Psychological and physiological effects of 2,5-dimethoxy-4-ethyl amphetamine (DOET) in man.


Anesthesiologist sued for injury to teeth.


Why bother with conventions?

Why bother with conventions?


Simplified indices for estimating the prevalence of dental caries-experience in children seven to twelve years of age.


Implant dentistry at the First Internationa Dental Congress and XXI National Spanish Dental Meeting.


Quantitative studies on tissue transplantation immunity. IX. Induction of tolerance with antilymphocytic serum.


The induction of chromosome aberrations by nitrogen mustard and its dependence on DNA synthesis.


Sock inner sole.

Sock inner sole.


Substrate-induced efflux of anions from bovine adrenal cortex mitochondria and its relationship to steroidogenesis.


ICN Congress report.

ICN Congress report.


The Prader-Labhart-Willi syndrome.

The Prader-Labhart-Willi syndrome.


Contributions of medicinal chemistry to medicine from 1935.


Magnesium pemoline and job performance in mentally handicapped workers.


Antiarrhythmic compounds.

Antiarrhythmic compounds.


Purification and properties of rat liver tyrosine aminotransferase.


Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components.


The conversion of lycopene-15,15'-3H to cyclic carotenes by soluble extracts of higher plant plastids.


Fluroxene anesthesia for pheochromocytoma removal.


Effect of glycopyrrolate and brompheniramine maleate on the recurrence rate of duodenal ulcer.


Maldescended testicles.

Maldescended testicles.


Ipecac syrup in acute poisoning in children.


Regulation of branched biosynthetic pathways in bacteria.


Torsion of an intra-abdominal testicle. A case report.


Fractures of the os calcis.

Fractures of the os calcis.


The effect of urea on gastric acid secretion.


Periarteritis nodosa and bilateral facial paralysis.


Chemical, electron microscopic and physiological observations on the role of catecholamines in the carotid body.


Interaction of influenza virus with leukocytes and its effect on phagocytosis.


A. The blood clotting mechanism. The development of a theory of blood coagulation.


Biochemical aspects of blood coagulation.


B. The fibrinolytic mechanism. The mechanism of fibrinolysis.


The observations on which the theory of blood coagulation is based.


The fibrinolytic activation mechanism in human plasma.


The signficance of fibrinolysis. The significance of the fibrinolytic mechanism.


The dynamics of the renin-angiotensin system.


D. The kinin system. A history and review of the kinin system.


Enzymic aspects of plasma kinin formation.


Effect of clomiphene and compound 48-80 on uterine glycogen in the rat.


Clinical and pathological aspects of kinins in man.


E. Complement. The immunochemistry of complement.


Some functions of complement.

Some functions of complement.


F. The relation of complement to other systems.


G. The relation of the fibrinolytic mechanism to other systems. Influences on the kinin system by proteolysis in plasma.


Relation of the fibrinolytic mechanism to other proteolytic systems in plasma.


H. The kinetics of enzyme cascade systems. General kinetics of enzyme cascades.


The clotting plot--an analysis of the kinetics of the blood clotting reactions.


Mosquitoes for drawing blood from small reptiles.


A survey of a familial transmission of an anomalous autosome in group 13-15.


Characteristics of and hazards from local fallout.


Mosquito colonies in veterinary research.


Isolation of Bunyamwera-group viruses from Wisconsin mosquitoes.


Reduction of arbovirus plaque numbers by suspensions of normal mosquitoes.


Sulphite reductase from bakers' yeast: a haemoflavoprotein.


Effects of 5-azacytidine on polyribosomes and on the control of tyrosine transaminase activity in rat liver.


Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes.


The oxidation of glycine by D-amino acid oxidase in extracts of mammalian central nervous tissue.


The management of acute childhood poisoning.


Developments in sexual organogenesis.

Developments in sexual organogenesis.


The reaction of a mangabey monkey (Cercocebus galeritus agilis Milne-Edwards) to inoculation with yellow fever virus.


The reaction of a species of colobus monkey to inoculation with yellow fever virus.


The management of respiratory insufficiency in myocardial infarction.


Cortisone in clinical otorhinolaryngology. Its action mechanisms; its indications; its contraindications.


The Yukon school dental care experiment.


Metabolism of hexoses in the intact mosquito: exclusion of glucose and trehalose as intermediates.


Optimum fluoride concentration for arctic and sub-arctic water supplies.


Some effects of unilateral cryptorchism and vasectomy on sexual development of the pubescent ram and bull.


The heterogeneity of rat brain mitochondria isolated on continuous sucrose gradients.


Synthesis of adenosine triphosphate by myelin of spinal nerves of rabbit.


Application of differential scanning calorimetry to the study of sulphathiazole crystal forms.


Effect of vitamin C deficiency on the metabolism of drugs and NADPH-linked electron transport system in liver microsomes.


Species differences in the alteration of drug-metabolizing activities of liver microsomes by thyroxine treatment.


Depressor response to noradrenaline in hypothermic cats.


"Mechanical" hemolytic anemia improved by corticosteroids. Patient with mitral insufficiency at the prosthetic valve in a case of Marfan's syndrome.


Preliminary studies on oral health conditions in Malta.


The reaction mechanism of glutathione reductase from human erythrocytes.


Mechanism of enzyme action. V. Demonstration of an initial step of enzyme-substrate complex using D-amino-acid oxidase and D-lactate or D-mandelate.


Relationship between stability and state of association in glutamate dehydrogenase.


Space craft sterilization.

Space craft sterilization.


Triacetic acid lactone, a derailment product of fatty acid biosynthesis.


Microsomal marker enzymes and their limitations in distinguishing the outer membrane of rat liver mitochondria from the microsomes.


Founder of a State Medical Journal, Dr. George N. Kreider.


The Illinois Medical Journal and the State Society.


Biochemistry of the erythrocyte.

Biochemistry of the erythrocyte.


Fracture of the femur with popliteal arterial injury.


Normal and abnormal gait patterns.

Normal and abnormal gait patterns.


One year's experience in a small community hospital.


The coronary care unit in a non-teaching hospital.


Rehabilitation of geriatric patients.

Rehabilitation of geriatric patients.


Community child care. The role of the Neighborhood Health Center.


An examination of the effects of stimulant and depressant drugs on escape avoidance conditioning in strains of rats selectively bred for emotionality non-emotionality: intertrial activity.


Effects of phenylephrine, butylsympatol, pilocarpine, and lithium on runout of 86Rb from isolated rabbit ciliary processes.


Structure-activity relationships in the adrenergic-blocking agents.


Effect of certain drugs on perfused human placenta. IX. Mode of action of angiotensin.


Bee and wasp stings.

Bee and wasp stings.


Uncommon disease onsets with dysphagia.

Uncommon disease onsets with dysphagia.


Accidental injection of S.19 vaccine.

Accidental injection of S.19 vaccine.


Permissible base sequences for non self complementary messenger RNAs.


Studies on the chemistry of lichens. VII. Chemical investigations of the lichen species Lecanora (Aspicilia) Myrinii (Fr.) Nyl.


A note on in vitro inhibition of thymine degradation by some pyrimidine analogues and related products.


The effect of isoniazid on nicotinamide nucleotide concentrations in tubercle bacilli. A correction and further observations.


Identical transformability of both strands of recipient DNA in Diplococcus pneumoniae.


Surgical treatment of brown spider bites.


Studies on soluble and mitochondrial tyrosine aminotransferase: evidence for a physical change in the cytosol enzyme during induction.


Cardiovascular effects of the 1-(2" pyrimidyl)-5 piperonyl piperazine (ET 495).


Species dependent effects of doxapram HCl on alcohol dehydrogenase activity.


Diencephalic pathology in the clinical picture of certain collagenoses in young and middle aged patients.


Brain disorders induced by pharmacological blockade of the pentose phosphate pathway.


Immunochemistry and genetics of a "new" allotypic specificity Ae14 of rabbit gamma-G immunoglobulins: recombination in somatic cells.


Growth inhibition of Crithidia fasciculata by serotoninergic and adrenergic drugs.


Periarteritis nodosa with perirenal hemorrhage: a case report with angiographic findings.


Some properties and distribution of the omega-hydroxylation system of medium-chain fatty acids.


Microsomal hydroxylation of decane.

Microsomal hydroxylation of decane.


The dehydrogenation of 5 beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetrol by rat liver.


Electrophoretic characterization of glucose-6-phosphate dehydrogenase (G6PD) in granulocytes and lymphocytes of normal and fava bean-sensitive subjects.


Midsummer in Montreal.

Midsummer in Montreal.


Croeso '69--welcome '69.

Croeso '69--welcome '69.


The possible role of pleuropneumonia-like organisms in neurological disease.


Reactions of glycine synthesis and glycine cleavage catalyzed by extracts of Arthrobacter globiformis grown on glycine.


A fluorescent protein factor from spinach chloroplasts.


The microsomal oxygenation of ethyl benzene: isotopic, stereochemical, and induction studies.


Goodpasture's syndrome and its radiological features.


Enzymic pathway for thyroxine synthesis through p-hydroxy-3,5-diiodophenylpyruvic acid.


Student dental health program of the University of Alabama in Birmingham. I. The influence of dental treatment on DMF rates.


Adrenergic receptors in the veins of the dog.


Medicine and the moon flight.

Medicine and the moon flight.


Hereditary cryptorchidism.

Hereditary cryptorchidism.


First steps in biological nitrogen fixation.


Biology and ecology of nitrogen fixation by symbiotic associations of non-leguminous plants.


The peroxisome: a new cytoplasmic organelle.


The hydration structure of collagen.

The hydration structure of collagen.


Photoreactivity (3655 Angstrom) of various skin-photosensitizing furocoumarins with nucleic acids.


Experimental pathogenicity of Tribec arbovirus of mice.


Selection of herpes simplex virus mutants sensitive to sulphated agar polysaccharides.


Inactivation of viruses by phenethyl alcohol at temperatures below and above 0 degrees C.


Relation of parotid flow rate, sodium, potassium, and chloride concentrations to caries experience.


Combined effects of diphenyliodonium chloride, pine oils, and mustard oil soaps on certain microorganisms. Bactericidal and bacteriostatic activities of an emulsion containing 10.0% (v/v) terpineol, 0.5% (w/v) diphenyliodonium chloride, 11.0% (v/v) ethyl alcohol, and 5.62% saponified mustard oil were tested against a number of different types of organisms. The bactericidal concentration for Salmonella typhosa was 1:400. In the presence of 5.0% horse serum, it increased to 1:250. The bacteriostatic concentration varied from organism to organism; Escherichia coli and Staphylococcus aureus required 4,000 mug/ml for complete bacteriostasis, whereas Corynebacterium diphtheriae, Salmonella paratyphi-A, and Shigella required only 2,000 mug/ml for complete inhibition. A 4.0% concentration of the emulsion killed the spores of Bacillus subtilis within 6 hr.


Cytogenetical analysis of an ovine male pseudohermaphrodite and the possible role of the Y chromosome in cryptorchidism of sheep.


Antipseudomonal activity of alpha-sulfoaminopenicillins. A series of penicillins characterized by the presence of a sulfoamino or a modified sulfoamino group in the side chain was subjected to in vitro antimicrobial screening tests. Although the most potent members of the series were less active than benzylpenicillin against gram-positive bacteria and comparably active against most gram-negative bacteria, they were, on the average, 8 to 16 times more effective against strains of Pseudomonas aeruginosa. In other comparative laboratory tests against P. aeruginosa, these compounds were about as active as carbenicillin and four to eight times more active than ampicillin. An examination of structure-activity relationships indicated that maximal potency was obtained with penicillins having an alpha-(aromatic or heteroaromatic)-alpha-sulfoaminoacetamido side chain. The compound with an alpha-phenyl group was comparable in activity to those having an alpha-(2- or 3-thienyl) group, whereas any modification in position or structure of the alpha-sulfoamino group reduced activity. Results of studies with a cell-free P. aeruginosa beta-lactamase suggest that the marked inhibitory effects of alpha-sulfoamino penicillins for P. aeruginosa can be attributed, at least in part, to their high degree of resistance to this enzyme. Some derivatives, however, had weak antipseudomonal activity, despite possessing a high degree of beta-lactamase resistance.


Annual meeting of the Endocrine Society in conjunction with International Congress of Endocrinology.


Morphogenesis in hydra. I. Peduncle and basal disc formation at the distal end of regenerating hydra after exposure to colchicine.


Steady-stake kinetics of one-substrate enzymic mechanisms involving two enzyme conformations. II. Kinetic treatment of a reversible mechanism: effects of modifiers and product inhibition.


Genetic regulation of maltosaccharide utilization in Pneumococcus.


Uterine bleeding in rhesus monkeys after intrauterine contraceptive device insertion: effect of long-acting antihistaminic drugs.


Site-specific uncoupling of photosynthetic phosphorylation in spinach chloroplasts.


Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group.


Renal vein thrombosis in cases of polyarteritis nodosa and of the Henoch-Schoenlein syndrome. The occurrence of renal vein thrombosis in a case each of polyarteritis nodosa and the Henoch-Schoenlein syndrome is reported. It is suggested that obliteration of the arterioles that supply the walls of the veins may have initiated the venous thrombosis in these two cases.


"Tavegyl" (meclastine): a pilot trial in allergic rhinitis.


Butaperazine maleate (Repoise maleate).

Butaperazine maleate (Repoise maleate).


Effect of carbon tetrachloride on induction of liver enzymes by acute stress or corticosterone.


The role of serum factors in the enhancement of phagocytosis.


Para-infectious and post-vaccinal encephalomyelitis.


Disseminad vasculomyelinopathy. A review of the clinical and pathologic reactions of the nervous system in hyperergic diseases.


Carcinoma multiplex.

Carcinoma multiplex.


Deadline for opinion survey.

Deadline for opinion survey.


Portal hypertension due to schistosomiasis.


Psychological and physiological aspects of drug treatment in older children.


The Illinois school code. Current physical examination and immunization procedures.


Reactions to drugs.

Reactions to drugs.


Enzymatic treatment of fissure in ano.

Enzymatic treatment of fissure in ano.


On the quality of the physician's life.

On the quality of the physician's life.


Systemic disease in traumatic splenic rupture.


Jacksonville. First in state institutions.


Current needs of the food service industry.


Histamines and antihistamines.

Histamines and antihistamines.


A comparative study of beta-adrenergic blocking drugs as infiltration anaesthetic.


Bullrout stings.

Bullrout stings.


Participant list. 20th National Dental Health Conference, April 14-16, 1969.


Monoamine oxidase activity of the cat nictitating membrane and superior cervical ganglion under various experimental conditions.


The inhibitory effect of aureomycin (chlortetracycline) pretreatment on some rat liver microsomal enzyme activities.


Effect of N-bromosuccinimide on dihydrofolate reductase.


Caries experience of 15-year-old children from fluoride and non-fluoride communities.


Stannous fluoride and sodium monofluorophosphate dentifrices. Clinical testing in London school children--radiological findings.


Antagonism of ventricular arrhythmias induced by digitalis--a neural phenomenon.


D-amino acid oxidase induction in the kidneys of germ-free mice. High levels of d-amino acid oxidase activity were found in the kidneys of conventionally reared mice, whereas the enzyme was absent from the kidneys of most germ-free mice. Injection of d-alanine or monocontamination with Bacillus cereus stimulated d-amino acid oxidase activity in the kidneys of germ-free mice.


CO-binding pigment (P-450) and other electron transport components in hepatoma bearing rats.


Psychiatry--psychiatric screening.

Psychiatry--psychiatric screening.


The pharmacolgy of 5-(2-t-butylamino-1-hydroxyethyl) salicylamide (ah 3474), a beta-adrenoreceptor blocking agent.


Simulation of the apparent effects of mebanazine on growth hormone by pair-feeding of control animals.


Evaluating acidulated phosphate fluoride solution as a caries inhibitor.


Comparison of intracisternally and intraperitoneally injected harmaline on body temperature and tremor in the rat.


Prostaglandin e1 action on canine isolated tracheal muscle.


Effect of glycopyrronium bromide on basal, and histamine- or gastrin-induced gastric secretion.


The effect of two synthetic steroids on the ultrastructure of the liver of rattus norvegicus l.


The effect of 1,1-dimethyl-4-phenyl-piperazinium on the response of mesenteric arteries to sympathetic nerve stimulation.


A note on the colorimetric determination of butyrophenones with 3,5-dinitrobenzoic acid.


The control of oil-in-water emulsion consistency using mixed emulsifiers.


Basic dihydromorphanthridinones with anticonvulsant activity.


The non-specificity of diethyldithiocarbamate.


Effect of a single dose of phentolamine and mj 1999 on aspirin-induced gastric ulceration in rats.


An antihistamine compound with potent antibradykinin activity.


The effects of reserpine on the distribution of [14c]5-hydroxytryptamine in the rat.


The effect of narcotics and narcotic antagonists on the tail-flick response in spinal mice.


Inhibition by morphine of the release of [14c]acetylcholine from rat brain cortex slices.


Monoamine oxidase inhibition and bretylium on adrenergic neuronal transmission.


Oxidation of chlorprothixene with ceric sulphate.


Absence of central nervous system effects of practalol [ICI 50,172; 4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide], a new adrenergic beta-receptor blocking drug.


Fenfluramine and body temperature.

Fenfluramine and body temperature.


Antidotes for phosgene-induced pulmonary oedema.


Autonomic blocking drugs on circulatory adaptations at rest and during exercise in man. Pronethalol and poldine in long-term treatment.


Modification of rabbit body temperature induced by the simultaneous injection of gonococcus vaccine and various phenothiazine neuroleptics.


Regulation of isocitrate dehydrogenase from thiobacullus thiooxidans and Pseudomonas fluorescens.


Gas chromatographic analysis of amine mixtures in drug formulations.


Synthesis of amodel system for the primary energy conversion reactions in photosynthesis. A model system is constructed which, like the photosynthetic apparatus of green plants, can convert light to chemical free energy through pigment-sensitized photooxidation of water. The system has two light-harvesting subunits connected electrically in series. Each subunit is made of a multimolecular layer of Zn(II)-tetraphenylporphyrin deposited on a clean aluminum surface and immersed in an aqueous mixture of potassium ferri- and ferrocyanide. Upon illumination by amber light, charge transfer takes place across more than 70 molecular layers of the pigment with a photoelectromotive force of 1.1 to 1.3 volts per subunit. With NADP as the electron acceptor and NADP-reductase as a mediator, the system can photooxidize water to oxygen gas. With these model experiments as a guide, a molecular mechanism for the primary energy conversion reactions in photosynthesis is formulated that offers a unified interpretation of most of the relevant observations reported in the literature.


Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat. The extraneuronal spontaneous efflux of (3)H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the (3)H amine in superfusates of isolated striatum of the rat previously incubated with (3)H-tyrosine. The (3)H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of (3)H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.


D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system. D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.


A new ribonucleotide reductase system after infection with phage T4. The ribonucleotide reductase system of Escherichia coli B participates in the biosynthesis of DNA by reducing ribonucleoside diphosphates to the corresponding deoxyribonucleotides. The enzyme is regulated in a complicated way by allosteric modifiers. We now find that infection of E. coli with the bacteriophage T4 results in the appearance of a new ribonucleotide reductase system which shows a somewhat different pattern of regulation. Two new proteins, provisionally called fractions A and B, were purified from the extracts of infected bacteria. The reduction of ribonucleotides by these two fractions required the addition of either dithiothreitol or TPNH and E. coli thioredoxin reductase. Mutants of T4 which lacked fraction A activity were obtained. Fraction B may be a virus-induced thioredoxin.


Influence of antiadrenergic measures on the blood catecholamine level in protracted intracranial hypertension.


Synthesis of long-chain fatty acids in mitochondria.


Oxidation of n-hexadecane by mouse liver microsomal fraction.


Is fresh water Hydra vulgaris attenuata a spirochaetales' reservoir host?


The effect of some anticholinesterase agents and of hemicholinium on the amount of substance P in rabbit brain and gut.


Anaphylaxis in demethylchlortetracycline.


The doctor in space.

The doctor in space.


The reactivity of flavoproteins with sulfite. Possible relevance to the problem of oxygen reactivity.


Tryptophan metabolism of rats fed a threonine-free amino acid diet.


Absence of hyperchromic effect in DNA heated above Tm., in the presence of tryptophan.


The role of DNA concentration.

The role of DNA concentration.


The nature of electrode processes of guanine and its derivatives. II. Effect of substitution.


Thermal denaturation equilibria of TMV coat proteins with chemically defined differences in their primary structure.


Adrenal medullary hormones and phenothiazine: effects on the Arthus reaction in adult rabbits.


Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.


Studies on the mechanism of drug-induced bronchiolar relaxation in the guinea pig.


The effects of reserpine, alpha-methyltyrosine, and L-3,4-dihydroxyphenylalanine on brain tyrosine transaminase. The effects of a variety of pharmacological and physiological manipulations on the activity of hepatic tyrosine transminase have been extensively investigated. Brain tyrosine transaminase, however, has received only limited attention. Since tyrosine transaminase may be important in the regulation of catecholamine biosynthesis in the brain, the effects of agents affecting catecholamine storage and synthesis on brain tyrosine transamination were investigated. Transamination in the 12,000 x g fraction was measured by a radioactive procedure. alpha-Methyltyrosine and reserpine, agents which deplete brain catecholamines, decreased tyrosine transaminase activity. Administration of the catecholamine precursor, L-3,4-dihydroxyphenylalanine to the reserpine-and alpha-methyltyrosine-treated rats elevated the tyrosine transaminase activity to normal. The possible implications of these findings in the regulation of the biosynthesis of the catecholamines are discussed.


Propiomazine, pentobarbital, hydroxyzine, and placebo: double-blind comparison of sedative effects.


Biosynthesis of microsomal nicotinamide-adenine dinucleotide phosphate-cytochrome c reductase by membrane-bound and free polysomes from rat liver. 1. NADPH-ferricytochrome c oxidoreductase (EC 1.6.2.3) was purified from the endoplasmic reticulum of rat liver cells. The methods, which involved digestion of membrane with Steapsin, a crude pancreatic extract containing diastase and trypsin, gel filtration and preparative electrophoresis on polyacrylamide, provided an enzyme with a high specific activity in good yield. 2. The incorporation of (14)C-labelled amino acids into the purified reductase by the incubation of various subcellular fractions was studied. The microsome fraction, bound polysomes, free polysomes and detergent-treated polysomes effected the synthesis of the enzyme. 3. The reductase that had been synthesized by the polysomes was tightly bound to preparations of smooth-surfaced endoplasmic reticulum that were added to the incubation medium. 4. Reductase activity could be detected on both free and detergent-treated polysomes. Evidence is presented to show that this activity was due, at least in part, to the presence on the ribosomes of nascent enzyme. The association of enzyme with detergent-treated polysomes did not appear to be due to contamination of the ribosomes with either membrane or cell sap but it is possible for such ribosomes to adsorb some enzyme. 5. The amount of reductase activity associated with the detergent-treated polysomes was increased when the rats from which the polysomes were derived had been previously injected with phenobarbitone. 6. The results are discussed with respect to their relevance for the question of the existence of two functionally different groups of polysomes in the liver and for current ideas on the biogenesis of membranes.


Enzymic changes in rabbit and rat mammary gland during the lactation cycle. 1. Activities of glucose 6-phosphate dehydrogenase (EC 1.1.1.49), 6-phosphogluconate dehydrogenase (EC 1.1.1.44), isocitrate dehydrogenase (EC 1.1.1.42), malate dehydrogenase (EC 1.1.1.37), malate dehydrogenase (decarboxylating) (EC 1.1.1.40), and pyruvate carboxylase (EC 6.4.1.1) were determined in subcellular fractions of mammary gland from rabbits during pregnancy, at different stages of lactation and during weaning. The results were compared with those obtained in similar experiments with rat mammary gland. 2. Three bases of expression of the activity of enzymes in the particle-free supernatant fraction of mammary gland were compared. During lactation, activity expressed per mg. of particle-free supernatant protein (uncorrected for milk protein) correlated well with that expressed per mug. of DNA phosphorus. The disadvantages of expressing activities per g. wet wt. are discussed. 3. The major differences between the two tissues were: (a) neither malate dehydrogenase (decarboxylating) nor a soluble form of pyruvate carboxylase could be detected in rabbit mammary gland at any stage of the lactation cycle; (b) isocitrate dehydrogenase increased in activity during lactation in rabbit mammary gland, but not in that of the rat. 4. Pyruvate carboxylase in the mitochondrial fraction of rabbit mammary gland, and in both the mitochondrial and the soluble fractions of rat mammary gland, did not change in activity during lactation. 5. For each tissue, the NADP-dependent dehydrogenases studied had a high activity at all stages of the lactation cycle compared with the rate of fatty acid synthesis at mid-lactation. The significance of these results is discussed with respect to the supply of NADPH via NADH.


The metabolism of D-glyceraldehyde by the lens. 1. The metabolism of d-glyceraldehyde by the lens was examined. 2. When low concentrations of d-[U-(14)C]glyceraldehyde were incubated with lens extracts there was no incorporation of the label into protein; more than two-thirds of the labelled metabolites consisted of glyceric acid and glycerol, their relative proportions depending on the species. Lactic acid, a phosphate, glutathione-glyceraldehyde compounds and a neutral compound were also formed. 3. When high concentrations of d-[U-(14)C]glyceraldehyde were incubated with lens, extensive incorporation of the label into protein occurred and the protein became yellow-brown. This coloured protein did not exhibit the fluorescent properties shown by the brown proteins of human cataractous senile lens, or of naphthaquinone-treated lens. 4. Evidence that d-glyceraldehyde is formed by the lens was sought but not found.


Syndrome of retardation with urogenital and skeletal anomalies (Smith-Lemli-Opitz syndrome): clinical features and mode of inheritance.


A.M.A. study group on medical education.


Electron microscopic radioautographic studies of the carotid body following injections of labeled biogenic amine precursors. Adult Syrian hamsters were given a subcutaneous injection of reserpine 3 days before an intraperitoneal injection of (3)H-3,4 dihydroxyphenylalanine or (3)H-5, hydroxytryptophan and the carotid bodies were subsequently prepared for electron microscopic radioautography. Other Syrian hamsters were given a subcutaneous injection of reserpine and the carotid bodies were subjected to a sensitive cytochemical test for the detection of unsubstituted amines. These studies were made to determine whether the labeled amine precursors were incorporated into the cells and to see whether the parenchymal cells were affected by reserpine treatment. Material from hamsters treated first with reserpine and subsequently injected with (3)H-3,4 dihydroxyphenylalanine or (3)H-5, hydroxytryptophan exhibited reduced grains of silver over the cells which were associated mainly with the dense cores of the cytoplasmic granules. These studies offer evidence that the granules of the carotid body incorporate catecholamine and indolamine precursors. Material from hamsters incubated for the presence of unsubstituted amines gave a positive reaction (opaque cytoplasmic granules) for catecholamines but not for indolamines. The latter substances may not be present in quantities sufficient to register a positive reaction in the cytochemical test. The opaque granules, indicative of the presence of catecholamines, decreased in density after reserpine treatment. 5 days after one reserpine injection the granules had regained opacity and were comparable to those seen in the control cells.


Evoked release of 5-HT and NEFA from the hypothalamus of the conscious monkey during thermoregulation.


Student dental health program of the University of Alabama in Birmingham. II. Socio-economic similarities and perceptual differences between two groups of nursing students.


Smallpox vaccine encephalomyelitis. (Case report).


Cerebral arteriolar spasm inhibited by beta-adrenergic blocking agents.


Genetic and biochemical studies of suppression of ribosomal resistance to streptomycin and erythromycin in Pneumococcus.


A genetic analysis by transformation of a group of uracil-requiring mutants of Diplococcus pneumoniae.


A study of the bronchoconstrictor and hypotensive actions of curarizing drugs by Charles M. Landmesser.


Oxygen electrode measurements in biochemical analysis.


C. The renin-angiotensin system. A history and review of the renin-angiotensin system.


Mechamism and stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5alpha-steroid.


The antibody response preceding immunological paralysis.


Dental survey of children in country districts of Queensland.


Effect of antihistamines on ribonucleic acid synthesis in the uterus of the ovariectomized rat.


Some relationships between the MMPI and 16 PF.


Similarities between effects of adenosine 3',5'-monophosphate and guanosine 3' 5'-monophosphate on liver and adrenal metabolism.


Classification of MMPI profiles using the Gilberstadt-Duker rules.


Differentiation of alcoholism from general psychopathology by means of two MMPI scales.


The Edwards SD scale: further evaluation and comment.


The modern nurse administrator.

The modern nurse administrator.


Needed: changes in hospitals to utilize the new practitioner in nursing.


Changing attitudes and approaches to nursing care through continuing education.


Changing the climate for nursing care.

Changing the climate for nursing care.


Associate degree nursing ... are changes needed in the practice field for new graduates?


Biliary flow after microsomal enzyme induction.