The lincoln dental caries study. II. The effect of acidulated carbonated beverages on the incidence of dental caries.


The epidemiology of venous thrombosis.

The epidemiology of venous thrombosis.


Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin.


Antigenic changes of L1210 leukemia in mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide.


Selective thymus-derived cell enrichment in the rat spleen as a result of immunodepression by urethan.


The mechanism of ligand-induced structural changes in glutamate dehydrogenase. Studies of the rate of depolymerization and isomerization effected by coenzymes and guanine nucleotides.


Multiple forms of Pseudomonas multivorans glucose-6-phosphate and 6-phosphogluconate dehydrogenases: differences in size, pyridine nucleotide specificity, and susceptibility to inhibition by adenosine 5'-triphosphate. Two major species of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) differing in size, pyridine nucleotide specificity, and susceptibility to inhibition by adenosine 5'-triphosphate (ATP) were detected in extracts of Pseudomonas multivorans (which has recently been shown to be synonymous with the species Pseudomonas cepacia) ATCC 17616. The large species (molecular weight ca. 230,000) was active with nicotinamide adenine dinucleotide (NAD) or nicotinamide adenine dinucleotide phosphate (NADP) and was markedly inhibited by ATP, which decreased its affinity for glucose-6-phosphate and for pyridine nucleotides. This form of the enzyme exhibited homotropic effects for glucose-6-phosphate. The small species (molecular weight ca. 96,000) was active with NADP but not with NAD, was not inhibited by ATP, and exhibited no homotropic effects for glucose-6-phosphate. Under certain conditions multiplicity of 6-phosphogluconate dehydrogenase (EC 1.1.1.43) activities was also noted. One form of the enzyme (80,000 molecular weight) was active with either NAD or NADP and was inhibited by ATP, which decreased its affinity for 6-phosphogluconate. The other form (120,000 molecular weight) was highly specific for NADP and was not susceptible to inhibition by ATP. Neither form of the enzyme exhibited homotropic effects for 6-phosphogluconate. The possible relationships between the different species of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase are discussed.


The Cheshire cat syndrome. A case report with electron microscopic findings.


The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.


Pediatric manpower problems are solvable.


Effect of neotetrazolium on sympathetic ganglionic transmission.


Clinical trial of LB-46 (d, 1-4-(2-hydroxy-3-isopropylaminopropoxy)indol. An adrenergic beta-receptor blocking agent in migraine prophylaxis.


Anticariogenic effect of dicalcium phosphate dihydrate chewing gum: results after two years.


Maternal modification of responsiveness in the ova-transfer substrain DBA-2eB.


Studies on the syntheses of heterocyclic compounds. 459. Synthesis of rescinnamine-like compounds as antihypertensive agents.


-adrenergic blocking agents. 3-(3-Substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles.


Personality and reactivity to stimulants and depressants.


Fatty acid synthetase of brain: development, influence of nutritional and hormonal factors and comparison with liver enzyme.


The absence of residual memory consolidation following transcranial current.


Psychosomatic medicine. IV. Psychosomatic aspects of coronary artery disease.


Beta-adrenergic blockade and peripheral circulation.


Medical-psychological implications of recent sleep research.


Visualization of glutamine synthetase and  -glutaminyl transferase in polyacrylamide gels.


Recent experimental, clinical, and therapeutic research on the problems of intraocular pressure and glaucoma.


Studies on the pharmacology of nuciferine and related aporphines.


Sensitivity changes of adrenergic  -receptors of isolated ileum and trachea preparations induced by alteration of temperature.


The action of cinnarizine on the contraction induced by calcium in depolarized arterial and intestinal smooth muscle preparations.


Improved purification of bovine adrenal iron-sulfur protein.


The kinetic features of monomers and dimers in high- and low-temperature conformational states of D-amino acid oxidase.


Reactivity of the veins in diabetes.

Reactivity of the veins in diabetes.


The effects of adrenergic drugs on the rabbit oviduct.


Interference of some thiol derivatives with the pharmacological effects of arachidonic acid and slow reacting substance C and with the release of rabbit aorta contracting substances.


Dental health of Puerto Rican migrant workers.


Local synthesis and breakdown of noradrenaline in constricted rat sciatic nerves.


A survey of attitudes of physicians on proper use of physician's assistants.


Immunodeficiency of the thymus-dependent system of the Ames dwarf mouse.


Heat labile opsonins to Pneumococcus. 3. The participation of immunoglobulin and of the alternate pathway of C3 activation.


The influence of carriers on the immune response of rabbits to the synthetic homopolymer poly ( -2-N-morpholinylethyl-L-glutamamide) (PAMEG).


A new model for the structure of the centriolar satellite complex in spermatozoa.


Instructional sets and MMPI items.

Instructional sets and MMPI items.


Microbodies (peroxisomes) in the interstitial cells of rodent testes.


Propiomazine protection in CCl 4  hepatic injury. An electron microscopic study.


Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.


LB-46, a new beta-adrenergic receptor blocking agent in cardiac arrhythmias.


Wound healing. A thermographic study.

Wound healing. A thermographic study.


The isolated frog skin epithelium: presence of alpha and beta adrenergic receptors regulating active sodium transport and water permeability.


The effects of some beta adrenergic blocking agents on the central and peripheral actions of tremorine and oxotremorine.


Alpha and beta adrenergic receptors in the coronary vascular bed.


NADP-linked dehydrogenases in Duchenne muscular dystrophy.


Metabolic changes during spermatogenesis and thoracic tissue maturation in Drosophila hydei.


Histochemistry of human cardiac muscle in ontogenesis.  Variations in the dehydrogenase and phosphatase systems.


Enzyme histochemical studies on rat lungs. 2. Normal enzyme distribution in the alveolar tissue of the mature lung.


Polyarteritis nodosa presenting with gangrene of extremities. A case report.


Replication of DNA in the chromosomes of eukaryotes.


The Leeuwenhoek lecture, 1971. Tumour viruses and the sociology of fibroblasts.


A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat.


Role of Minnesota Multiphasic Personality Inventory in the diagnosis of psychiatric conditions.


Determination of iron in the acid-soluble fraction of human erythrocytes.


Occurrence of phenylalanine hydroxylation in the pineal gland in vivo: possible role of tyrosine and tryptophan hydroxylases.


Changes in the patency of the dog's eustachian tube induced by histamine and antihistamines.


The pharmacology of passive cutaneous anaphylaxis in the calf.


Pressor effect of beta blocking agents in rats.


Adverse reaction to salazopyrin.

Adverse reaction to salazopyrin.


Amphetamine controls.

Amphetamine controls.


Relations of various collagens, elastin, resilin and fibroin.


Effects of drugs on ocular muscles.

Effects of drugs on ocular muscles.


Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition. The properties of partially purified tyrosine hydroxylase from six pheochromocytomas were compared with partially purified normal human and bovine adrenal medulla enzyme. Substrate and inhibition kinetics, cofactor requirements, and intracellular localization of the enzyme from normal and tumor chromaffin tissue of humans were similar, as was the amount of enzyme activity per gram of tissue. Contrary to previous reports, the sensitivity to catecholamine inhibition of the pheochromocytoma enzyme from the six tumors studied was similar to that of both human and bovine adrenal medulla tyrosine hydroxylase. These results suggest that the excessive synthesis and secretion of catecholamines in some pheochromocytomas is not the result of a reduced sensitivity of tyrosine hydroxylase to catecholamine inhibition.


Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization. The pathogenesis of the male pseudohermaphroditism in the mouse with X-linked testicular feminization (Tfm) has been investigated by comparing testosterone formation, the effects of androgen administration, and the metabolism of testosterone-1,2-(3)H in normal mice and Tfm mice of varying ages. First, it was established that the adult Tfm animal, in contrast to the human with testicular feminization, has both a low serum testosterone and a low rate of testosterone formation as assessed in slices of testes utilizing a variety of precursors. However, the formation of testosterone from pregnenolone-7alpha-(3)H was shown to be normal in newborn Tfm testes, suggesting that a defect in testosterone synthesis may not be primary to this mutation. Second, to establish that the pseudohermaphroditic state is due to androgen resistance rather than to diminished androgen biosynthesis during fetal life, the effect of the administration of dihydrotestosterone to pregnant animals was studied in male, female, and Tfm offspring. Whereas normal and carrier female littermates demonstrated striking virilization of the internal genital tract after such treatment, there was no sign of virilization in the Tfm animals. This finding provides direct experimental evidence in support of the view that male pseudohermaphroditism in testicular feminization is the result of resistance to androgen action during androgen-mediated sexual differentiation in embryos. Third, the metabolism of testosterone-1,2-(3)H was investigated both in tissue slices and in functionally hepatectomized animals. Dihydrotestosterone formation in tissue slices of the fetal anlage of the male organs of accessory reproduction is normal in the Tfm animal, suggesting that the primary defect in this disorder involves an intracellular event subsequent to this step and that the deficient dihydrotestosterone formation observed in the adult genital tract of the Tfm mouse is secondary to the failure of differentiation in these tissues. Finally, deficient binding of testosterone in the nuclei of the submandibular gland of adult Tfm animals, a known testosterone target tissue, was demonstrated in functionally hepatectomized mice. This finding could either be a manifestation of the primary genetic defect in this disorder or might reflect another acquired abnormality due to incomplete differentiation of adrogen-sensitive cell lines.


Judgmental dimensions of psychopathology.


An effect of extrarenal beta adrenergic stimulation on the release of renin. The present study was undertaken to examine whether the beta adrenergic agonist, isoproterenol, increases plasma renin activity (PRA) by activation of intrarenal or extrarenal pathways. The effects of intravenous (i.v.) and renal arterial infusion of isoproterenol on PRA and renin secretion rate (RSR) were compared in anesthetized dogs. In 12 studies in 9 dogs i.v. infusion of isoproterenol (0.009-0.018 mug/kg per min) was associated with an increase in PRA from 14.7 to 35.7 ng/ml per 3 hr (P < 0.001). PRA decreased to 19.4 ng/ml per 3 hr (P < 0.001) after cessation of the infusion. In innervated kidneys RSR increased from 1640 to 5062 U/min (P < 0.02) and decreased to 2132 U/min after cessation of the infusion (P < 0.05). In denervated kidneys the control RSR was significantly lower (455 U/min) but still increased during i.v. infusion of isoproterenol to 2762 U/min (P < 0.001) and decreased to 935 U/min (P < 0.001) after the infusion was stopped. These changes in PRA and RSR were associated with an increase in cardiac output averaging 49% and a large decrease in total peripheral resistance. These effects of i.v. isoproterenol to increase RSR were not mediated by changes in renal perfusion pressure since this was held constant by adjusting a suprarenal aortic clamp. In addition, there were no changes in glomerular filtration rate, renal plasma flow, or electrolyte excretion in either denervated or innervated kidneys during i.v. infusion of isoproterenol, and the concentration of potassium in plasma was unchanged. Prior hypophysectomy abolished the antidiuretic effect of i.v. isoproterenol but did not prevent the effect on RSR. In contrast, renal arterial infusion of isoproterenol at the same dose had no apparent effect on PRA and RSR in seven studies in five dogs and also did not produce changes in cardiac output, peripheral resistance or renal hemodynamics. These results do not provide evidence for a role of intrarenal beta adrenergic receptors in the control of renin release and indicate that the effect of beta adrenergic stimulation with isoproterenol to increase the release of renin is mediated by an extrarenal mechanism. Since the effect of i.v. isoproterenol occurred in the absence of changes in plasma potassium concentration, renal perfusion pressure, glomerular filtration rate, renal plasma flow, and electrolyte excretion and was not abolished by renal denervation, the possibility must be considered that the effect on renin secretion is mediated by circulatory factors. The changes in systemic hemodynamics which occurred with i.v. but not renal arterial infusion of isoproterenol may be involved in the initiation of such a pathway.


Roles of impression management in the interview, self-report, and cognitive behavior of schizophrenics.


Clinical judgment as a means of improving actuarial prediction from the MMPI.


Item ambiguity in the 16 PF and MMPI: an assessment and comparison.


The importance of platelet function tests in toxicological screening using laboratory animals.


Stimulation of oxidative metabolism in polymorphonuclear leukocytes by catecholamines.


AAHA '72.

AAHA '72.


Steroid control of genomic expression in embryonic chick retina.


Central hemodynamics in severe poisoning by hypnotic drugs. Coma depth and body temperature.


The effects of the sympathetic nervous system on accommodation. II. Alpha sympathetic nervous system.


The effects of the sympathetic nervous system on accommodation. I. Beta sympathetic nervous system.


Regulation of the two "malic" enzymes in Neurospora crassa.


Epidemiologic studies of caries-free and caries-active students. II. Diet, dental plaque, and oral hygiene.


Hyperbaric chamber noise during a dive to 100 ft.


Dental and associated attitudinal aspects of heroin addiction: a pilot study.


Comparison of DMF teeth scores between Caucasian and Negro male alcoholics.


Possible mechanism (s) of alprenolol (beta adrenergic receptor blocking agent) prolongation of pentobarbital hypnosis in mice.


Azulfidine agranulocytosis with bone marrow, megakaryocytosis, histiocytosis and plasmacytosis.


The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.


Physician's assistant in peripheral vascular disease--pilot program.


Potentiation of bronchomotor responses by beta adrenergic antagonists.


Chromosome characterization of three cell lines derived from Aedes albopictus (skuse) and Aedes aegypti (L.).


Portal pressure responses to catecholamines.


Cholesterogenesis during acute infection in chronically hypercholesterolemic rhesus monkeys.


An innovation in eye care.

An innovation in eye care.


Surgical trainees in the Duke Physician's Associate program.


Sulfonamide vasculitis.

Sulfonamide vasculitis.


Foot-rot in pigs: experimental production of the disease.


The mixed lymphocyte culture interaction. Techniques and immunogenetics.


Clemastine on hand-eye coordination and visual function.


Appraisal of current methods to estimate the turnover rate of serotonin and catecholamines in human brain.


A comparison of intravenous pindolol and propranolol in normal man.


The effect of pyridoxine deficiency on L-aromatic amino acid decarboxylase and tyrosine aminotransferase in developing brain.


Unitary alcoholism factor and its personality correlates.


Partial characterization of the alkylglycerol cleavage enzyme system of rat liver.


The response of T cells to histocompatibility-2 antigens. Dose-response kinetics. The DNA synthetic response of a wide variety of parental thymocyte doses was studied in the lymphoid tissues of lethally irradiated F(1) mice. The response curves of the thymocytes were strikingly similar in shape to those of T cells responding to antigens, such as sheep red cells, which are more labile than the histocompatibility antigens of the F(1) host. The response was characterized by a dose-dependent latent period of 1-3 days, followed by a sharp increase in activity and a significant subsequent shutoff. Larger thymocyte doses tended to shorten the latent period. A comparison of the responses of different cell doses to one another indicated that the response usually simulated a suppressed first-order reaction. However, occasional multiple order reactions were observed. We have interpreted these data to indicate that both positive and negative interactions occur between thymocytes, without the mediation of B cell products such as conventional antibodies.


Nurse as physician's assistant.

Nurse as physician's assistant.


Second National Conference on Breast Cancer, Los Angeles, California, May 17-19, 1971.


Cytotoxicity in graft-versus-host reaction. I. Role of donor and host spleen cells. Under in vitro conditions spleen cells from nonirradiated F(1) hybrids, in which a (graft-vs.-host) (GVH) reaction had been induced with lymphoid cells of parental origin, lysed nonspecifically target cells, i.e., cells syngeneic or allogeneic to the parental genotypes. Furthermore, tumor cells exposed in vitro to spleen cells of F(1) hybrid mice undergoing GVH reaction had markedly decreased ability to grow in syngeneic recipients. Experiments involving inhibition of cytotoxicity with alloantisera indicated that this nonspecific effect was due to host cells. By contrast, spleen cells of lethally irradiated F(1) hybrids undergoing GVH reaction lysed specifically the target cells of the genotype against which the parental (donor) cells had been sensitized; this finding further supports the contribution of host cells to the nonspecific cytotoxic effects in GVH reaction. From these results it was deduced that the cytotoxic effects during GVH reaction involve at least two processes: (a) sensitization of the donor cells to the antigens of the recipient resulting in the activation of their potential to lyse specifically the recipient's cells, and (b) activation of the host's cells into a state of nonspecific cytotoxicity, as a consequence of the immunologically specific attack of the donor cells.


The host cell response in the local graft-versus-host reaction induced in the kidneys of F 1  rats by parental thoracic duct lymphocytes. Radioautographs of infiltrative cells in the kidneys of (Lewis x BN)F(1) rats labeled with tritiated thymidine (TdR(3)H) before the subcapsular injection of parental (Lewis) thoracic duct lymphocytes (TDL) showed a predominantly host-proliferative response by 4 days after grafting. The immediate renal incorporation of TdR(3)H was used to measure the local graft-vs.-host (GVH) reactions. Substantial reactions could still be induced in the face of the considerable degree of leukopenia after 400 R whole body gamma-irradiation. These results suggest that radioresistant cells are capable of carrying on the appropriate host activities and that the weakness of GVH reactions induced after higher doses of irradiation may be due to impairment of the mitotic mechanism of host cells. The importance of circulating leukocytes as a source of immunogenic stimulation was nevertheless substantiated by inducing local GVH reactions with Lew TDL in chimeric parental-type rats that had been repopulated with F(1) bone marrow. This result also emphasizes the nonspecific nature of tissue destruction in the renal GVH reaction in confirmation of Elkins. In this and other situations in which B cells were the predominant F(1) type elements available for interaction with parental-type TDL the reactions were nearly equivalent or equivalent to those in the appropriate controls. Typical local GVH reactions could be induced in heavily irradiated hosts by an inoculum of combined parental and F(1)-type TDL in the apparent absence of mononuclear phagocytes. The possible relationship between the activation of host lymphocytes, the involvement of B cells, and the nonspecific nature of tissue damage in the renal GVH is discussed.


The organization of a cephalopod ganglion.


Inhibition of bacterial DNA replication by 6-(p-hydroxy-phenylazo)-uracil.


Regressing aneurysms in periarteritis nodosa. A report of 3 cases.


Chromosome rearrangements for the control of insect pests.


Replamineform: a new process for preparing porous ceramic, metal, and polymer prosthetic materials. The replamineform process (meaning replicated life forms) is a technique for duplicating the microstructure of carbonate skeletal components in ceramic, metal, or polymer materials. The special pore structures of marine invertebrate skeletal materials such as echinoid spines and corals, which are difficult or impossible to create artificially, can thus be copied in useful materials. Of immediate interest is the possibility of using these replicated microstructures in the fabrication of orthopedic prosthetic devices. By means of this technique, prosthetic materials having a controlled pore microstructure for optimum strength and tissue ingrowth may be obtained.


Detection of a retinol-like substance and the relative abundance of carotenoids in different tissues of the anthomedusa, Spirocodon saltatrix.


Failure to propagate equine arteritis virus in an Aedine and an Anopheline Mosquito species.


Correlation between enzyme activity, susceptibility to antibiotics and mercury bichloride, and phage type in coagulase-positive Staphylococci isolated from protein-rich salads.


Biological activities of bacterial proteins.


Virological studies on acute respiratory infections in childhood.


Amino acid pools and hepatic enzyme activities in rats fed a meal of high or low methionine content.


Juvenile Parkinsonism.

Juvenile Parkinsonism.


Acetylator phenotype and adverse effects of sulphasalazine in healthy subjects. Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were recorded. There was no correlation between the serum concentrations of sulphasalazine and the adverse effects. The slow acetylators obtained enhancement of serum concentrations of sulphapyridine earlier than the rapid acetylators. They also reported adverse effects earlier and of more pronounced nature than the rapid acetylators. The data as a whole suggest that the adverse effects observed were caused by the metabolite sulphapyridine and that they are influenced by the polymorphic acetylation.


Association of polyarteritis and Australia antigen.


A retroperitoneal approach to orchiopexy.


Prune belly syndrome.

Prune belly syndrome.


The role of adrenergic blockade in the treatment of ureteral colic.


Crossed renal ectopia.

Crossed renal ectopia.


Young people discuss drug education.

Young people discuss drug education.


Analysis of metabolic transients in intact cells by rapid microfluorimetry.


Maturation of reactivity to histocompatibility antigens.


Mixed lymphocyte culture and graft-versus-host analyses of organ-grafted rats that defy normal rules for rejection.


International Symposium of Vascular surgery. Introduction.


Role of regional lymphatics in tumor allograft rejection.


Induction of both host- and donor-type tumors as a result of the graft-versus-host reaction.


Suppression of transferred allogeneic plaque-forming cells in mice. Effect of presensitization of the recipient.


Liver infiltration in graft-versus-host reaction. Effect of anti-theta serum.


Antiarrhythmic drugs: electrophysiological actions.


Review of reviews.

Review of reviews.


The link between agonist action and response in smooth muscle.


Patient attitudes to the expanded role of the nurse in family practice.


California encephalitis virus: serological evidence of human infections in Alaska.


The university responsibility.

The university responsibility.


Positive dromotropic effects of the vagus nerves on the canine atrioventricular node.


Triad syndrome (a case report).

Triad syndrome (a case report).


Drug-induced and naturally occurring myeloid bodies.


The genetics of the mimetic butterfly Papilio polytes L.


Side effects of beta-adrenergic receptor stimulant bronchodilator drugs.


Enzymic oxidation of (-)-nicotine by guinea-pig tissues in vitro.


Aminoquinoline antimalarials--paradoxical regulation of hepatic tryptophan oxygenase and tyrosine aminotransferase by primaquine.


Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro.


Studies of the chemical nature of the  -adrenergic receptor. V. Validity of the receptor protection approach.


Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.


The intrinsic physiologic properties of the developing heart.


The influence of pretreatment with pronethalol on the toxicity of strospeside in the dog heart-lung preparation.


Enzymes of androgen biosynthesis in the desert mouse Gerbillus dasyurus.


Disciplinary problems in a home for older veterans: some psychological aspects in relation to drinking behavior.


[Protective action of drugs on the effects of murine hepatitis virus (MHV 3 )].


The drug treatment of learning disorders: continuing confusion.


Effect of triethylcholine on acetylcholine metabolism in the isolated guinea-pig ileum.


Collagen; ultrastructure and its relation to mechanical properties as a function of ageing.


The biosynthesis of octopamine.

The biosynthesis of octopamine.


Xanthoxin, a recently discovered plant growth inhibitor.


Studies on immunological paralysis. VII. Rapid reversal of Felton's paralysis as evidence for 'tolerant' cells.


Multiple endocrine adenomatosis.

Multiple endocrine adenomatosis.


NADH 2  generation in drug-induced porphyric rabbits.


Role of central dopaminergic receptors in manic response of cats to morphine.


Melanoma and trauma. A clinical study of Zulu feet under conditions of persistent and gross trauma.


Effects of pressure and muscle loading on the toxic actions of echinoderm saponins in neuromuscular tissues.


A comparative study of two procedures used in the determination of hepatic microsomal aniline hydroxylation.


Mechanism of broncho-constrictor action of some adrenergic beta-receptor antagonists.


Actions of emetine dehydroemetine, quinine and quinidine on Finkleman preparation of rabbit ileum.


Effect of some adrenergic receptor blocking drugs on early pregnancy in rats.


The type b capsulation locus of Haemophilus influenzae: map location and size.


Opsonic activity in human serum deficient in C2.


Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 1. Structure-activity relationships of agonists and antagonists of biogenic amines and of tricyclic tranquilizers and antidepressants.


Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 2. Effects of depolarizing agents, membrane stabilizers, phosphodiesterase inhibitors, and adenosine analogs.


Relationship between antihistamine and antidepressant activity in hexahydroindenopyridines.


Cross-validation of a heroin addiction scale from the Minnesota Multiphasic Personality Inventory.


Effects of 5,6-dihydroxytryptamine on monoaminergic neurones in the central nervous system of the rat.


Indications of psychopathology in male narcotic abusers, their effects and relation to treatment effectiveness.


Fluorides in community programs: a study for four years of the cariostatic effects of prophylactic pastes, rinses, and applications of various fluorides.


Symposium: behavior modification by drugs. II. Psychological effects of stimulant drugs in children with minimal brain dysfunction.


Associated acral and renal malformations: a new syndrome?


Otitis media: bacteriology and antibiotics.


Electrocardiogram of the month. Unusual reaction to propranolol.


Criteria for the use of specific forms of therapy for barbiturate overdose.


Use of alprenolol in acute cardiac arrhythmias.


Three families with abnormal, inherited chromosomes: 2q+mat, t(Cp+; 13q-)mat and t(3?-;5q+)pat.


Inhibition by  -blockade of the ST segment elevation after acute myocardial infarction in man.


The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma.


Evaluation of pyrovalerone in chronically fatigued volunteers.


Synthesis of some isoindolines and 1,2,3,4-tetrahydroisoquinolines and their evaluation as alpha-adrenergic and adrenergic neuron blocking agents.


Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.


Studies on the reaction mechanism of adenosine triphosphate: glutamine synthetase adenylyltransferase from Escherichia coli B. Evidence for an ordered mechanism.


Studies on the reaction mechanism of adenosine triphosphate: glutamine synthetase adenylyltransferase from Escherichia coli B. Conformational changes elicited by effectors and substrates: reactivity of sulfhydryl groups.


Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.


The minimal brain dysfunction syndrome in children. I. The syndrome and its relevance for psychiatry. II. A psychological and biochemical model for the syndrome.


Species identity of insect cell lines.

Species identity of insect cell lines.


Low molecular weight active form of inducible liver tyrosine aminotransferase.


End product inhibition of serotonin synthesis in the rat striatum.


Immune reactivity following poly I-poly C treatment in mice.


Hydrogen exchange and double bond formation in cholesterol biosynthesis.


Ability of splenic lymphocytes from injured rats to induce a graft-versus-host reaction.


Coelomic parabiosis of adult mice. Humoral antibodies and cellular chimerism.


Equivalent graft-versus-host reactivity of spleen cells from two lines of mice genetically selected for high and low humoral antibody formation.


Bone marrow transplantation from HL-A matched donors to patients with acute leukemia. Toxicity and antileukemic effect.


Development of a new skin antigen and of tolerance to this antigen in mice infected with a lymphomagenic virus.


Transmissibility of an attenuated Venezuelan equine encephalomyelitis vaccine virus.


Field tests with repellent-treated wide-mesh netting against mixed mosquito populations.


Further isolations of the arboviruses from mosquitoes collected in Tongaland, South Africa, 1960-1968.


The development of Loa loa (Guyot) in Mansonia africana (Theobald).


Biochemical aspects of phagocytic cells as related to bactericidal function.


The concept of immunity in dental caries. II. Specific immune responses.


Activation of leukemia viruses by graft-versus-host and mixed lymphocyte reactions in vitro. Spleen cells from BALB/c or CAF(1) mice released little or no detectable leukemia virus when cultured 2-7 days in vitro. In contrast, spleen cells of CAF(1) mice previously inoculated with parental BALB/c spleen cells released leukemia viruses in 10 of 11 cases studied. Cultures of a mixture of spleen cells from normal BALB/c and CAF(1) mice also contained leukemia viruses. Phytohemagglutinin induced the transformation of lymphocytes in cultures of CAF(1) or BALB/c spleen cells, but this transformation did not activate leukemia viruses. It is concluded that mixed lymphocyte cultures in vitro, just as graft-versus-host reactions in vivo, can activate leukemia viruses that are normally present in a repressed form. This activation is not solely a function of lymphocyte transformation. The activated mouse leukemia virus may subsequently account for the observed high incidence of neoplasia in graft-versus-host disease.


Evidence for reversible inactivation of induced tyrosine aminotransferase in rat liver in vivo. Induction of tyrosine aminotransferase (EC 2.6.1.5) with cortisol is followed by a rapid phase of inactivation of the enzyme, during which administration of puromycin causes a sharp increase in enzyme activity. The increase is not due to puromycin-resistant synthesis of protein, since precipitation of the enzyme with antibodies to tyrosine aminotransferase after pulse labeling inhibited incorporation of radioactive amino acids. Reactivation of the enzyme was specific, since the structurally similar dimethylaminopurine and purine aminonucleoside were ineffective. An action of puromycin other than its capacity to inhibit protein synthesis was required for reactivation, since cycloheximide did not demonstrate such an effect. In vitro studies with free and bound polysomes, isolated during the phase of inactivation, indicated that reactivation by puromycin was not due to release of nascent tyrosine aminotransferase peptides. We conclude that the enzyme is initially reversibly inactivated; therefore, the overall degradation of this intracellular protein is a multistep phenomenon.


Photoreduction of NADP +  sensitized by synthetic pigment systems. Two synthetic pigment systems capable of enzymatically photoreducing NADP(+) are described. One system contains proflavine; the other, acridine. The complete system consists of ethylene diamine tetraacetic acid (EDTA), proflavine (or acridine), ferredoxin-NADP reductase (EC 1.6.99.4), and NADP(+). The two pigments initiate the photoreduction of NADP(+) in different portions of the electromagnetic spectrum. Proflavine photosensitizes in the visible portion; acridine, in the ultraviolet. Neither proflavine nor acridine is structurally related to chlorophyll. The acridine system has the attractive property that the enzyme, ferredoxin-NADP reductase, is the only component of the system that absorbs appreciably in the visible region of the spectrum.


Inhibition of glucose-induced release of insulin by aldose reductase inhibitors. ALDOSE REDUCTASE (ALDITOL: NADP oxidoreductase, EC 1.1.1.21) is the enzyme responsible for the conversion of glucose to its sugar alcohol, sorbitol. In this study, aldose reductase and a closely related enzyme, L-hexonate dehydrogenase (L-gulonate: NADP oxidoreductase, EC 1.1.1.19), were purified from rat pancreas. Glutaric acid, 2,4-dimethyl glutaric acid, 3,3-tetramethylene glutaric acid, and colchicine inhibited both enzymes, albeit with different potencies. These compounds also inhibited both phases of glucose-induced release of insulin by the perfused rat pancreas. The potencies of these inhibitors in depressing the release of insulin correlated with their effectiveness in inhibiting aldose reductase. At higher concentrations of inhibitors, tolbutamide-induced release of insulin was also depressed. The addition of exogenous sorbitol to pancreases treated with glutaric acid restored their ability to respond to glucose and tolbutamide. These findings suggest that the conversion of free intracellular glucose to sorbitol in the beta cell is an essential step in the glucose-induced release mechanism.


Binding ratios by fluorescence with self-compensation for optical inner filter effects.


Radioactive assay for tyrosine aminotransferase.


Preferential inhibition by proflavine of the hormonal induction of glutamine synthetase in embryonic neural retina. The hormonal induction of glutamine synthetase (EC 6.3.1.2) in embryonic neural retina tissue in vitro is blocked preferentially and reversibly by proflavine (3,6-diaminoacridine) in the absence of cell or DNA replication; cell viability is not affected, and the synthesis of total cellular proteins and RNA is only slightly reduced. In the induction of this enzyme, there is a rapid increase in the synthesis and accumulation of the enzyme selectively elicited by the steroid inducer; for this effect, transcription is essential. Radioimmunochemical measurements have shown that proflavine inhibits induction by prevention of de novo synthesis of catalytically active and immunologically reactive glutamine synthetase protein. It does not measurably affect the uptake of the steroid inducer by the retina cells. Since the translation of this enzyme by preformed RNA templates is not stopped by proflavine, the inhibitory effect of proflavine on induction is apparently due to interference with transcriptional or pretranslational processes required for the provision of active transcripts for enzyme synthesis. The finding that proflavine inhibits preferentially a tissue-specific, inducible differentiation in postmitotic embryonic neural cells offers new approaches to the study of regulation of gene expression in eukaryotes.


Propericiazine in psychiatric emergencies. A controlled comparative study.


Inherited semisterility for control of harmful insects. V. Translocations in Culex tritaenio-rhynchus.


An epidemiological study of child health and nutrition in a northern Swedish county.


Study on the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. I. Crystallization and properties of the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes.


The management of the foot in leprosy.

The management of the foot in leprosy.


The respiratory-chain NADPH dehydrogenase of Azotobacter vinelandii.


Stereochemical course of decarboxylation of S-malate on malic enzyme.


Potentiating effect of Mycoplasma pneumoniae infection on the development of pneumococcal septicemia in hamsters.


Preparation and use of aequorin for rapid microdetermination of Ca 2+  in biological systems.


Left-sided valvular active infective endocarditis. A study of forty-five necropsy patients.


Right-sided valvular infective endocarditis. A clinicopathologic study of twelve necropsy patients.


Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy.


Cardiovascular actions of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) a new alpha-adrenergic receptor antagonist.


Interaction of amines and aminergic blocking agents with blood glucose regulation. I.  Beta-adrenergic blockade.


Identification and separation of antihistamines by thin-layer chromatography.


Interaction of amines and aminergic blocking agents with blood glucose regulation. II.  Alpha-adrenergic blockade.


Effect of central stimulants and depressants on mouse brain acetylcholine and choline levels.


Survey of Argentine medicinal plants. I. Folklore and phytochemical screening.


The hyperkinetic child and stimulant drugs.


Catecholamines.

Catecholamines.


Polymorphonuclear leukocyte activation: effects of phospholipase C.


Marihuana smoking. Cardiovascular effects in man and possible mechanisms.


The influence of neural blocking agents injected into the third ventricle of the rat brain and hypothalamic electrical stimulation on serum prolactin.


Health status of Brazilian Cayapo Indians.


Clinical trial with hycanthone in Schistosomiasis mansoni in Surinam.


Transamination of aromatic amino acids in rat liver and brain.


Inguinal herniography.

Inguinal herniography.


The Biometric Society, the first twenty-five years (1947-1972).


Planning-facilities, programs, and services-government and nongovernment.


An environmental chamber for the study of the physiology of conventional and germ-free laboratory animals.


Studies in cellular immunity. Wrinkles in the models.


Crystal and molecular structure of the antihistamine 2-((2)-dimethylaminoethyl-2-thenylamino)pyridine hydrochloride.


Dimensionality of MF.

Dimensionality of MF.


Age and a group test battery as predictors of types of crime.


International symposium on intermittent treatment with rifampicin.


Porteus Maze Test qualitative performance in pure sociopaths, prison normals and antisocial psychotics.


Endemic cretinism, iodine deficiency and foetal damage.


Interactions of lidocaine with general anesthetics.


A stochastic bioburden model for spacecraft sterilization.


Changing roles of physicians and nurses.


Periarteritis nodosa. A ten-year follow-up study of ten cases.


Effect of a coronary vasodilating substance, carbocromen, on the coronary blood flow under hypoxia and administration of adrenergic blocking agents.


Opposite effects of amiodarone and  -blocking agents on cardiac function under adrenergic stimulation.


Action of some  -blockers on plasma fibrinolysis in vitro and in vivo in man.


Excitation of mammalian central neurones by acidic amino acids.


DOPA decarboxylase in the developing rat brain.


Behavioral, biochemical, and histochemical analyses of the central effects of monoamine precursors after peripheral decarboxylase inhibition.


Alteration of rat brain catecholamine metabolism during exposure to hypobaric hypoxia.


Automation of a kinetic spectrophotometric assay for ATP: creatine phosphotransferase activity suitable for human serum and muscle extracts.


The pharmacology of thalamic and geniculate neurons.


Effect of poly I:C-induced interferon on herpes virus hominis infection in vitro and in vivo.


In vitro inhibition study of diphenylhydantoin upon rat liver enzymes in folic acid metabolism.


Serum hepatitis and the seroprophylaxis of measles.


Quantitative selection of respiratory deficient mutants in yeasts by triphenyltetrazolium chloride.


Interactions of concanavalin A with the membrane of infleunza virus infected cells and with envelope components of the virus particle.


Structural studies of the ribonucleoprotein G-antigen of influenza virus.


Action of angiotensin on adrenergic nerve endings: inhibition of norepinephrine uptake.


Open systems which can mutate between several steady states ("bioids") and a possible prebiological role of the autocatalytic condensation of formaldehyde.


Actions of angiotensin on the central nervous system.


A penile testis.

A penile testis.


Pteridine and riboflavin patterns during tail regeneration in Triturus species and the effects of chloramphenicol, isoxanthopterin and reserpine.


Pteridine and riboflavin in tumor tissue and the effect of chloramphenicol and isoxanthopterin.


Requirement of cellular RNA-synthesis for the inhibition of Semliki Forest Virus by poly (rI)-poly (rC).


Fish eggs: another new source of polyvalent proteinase-isoinhibitors.


Biosynthesis of juvenile hormone from 10-epoxy-7-ethyl-3,11-dimethyl-2,6-tridecadienoic acid in the adult cecropia moth.


The function of newer antiarrhythmic drugs under special consideration of beta blocking adrenergic agents.


Experimental myocardial necrosis.

Experimental myocardial necrosis.


Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.


Observations on the metabolism of cyclophosphamide.


The steroid 5 -reductase activity of rat liver and prostate.


Coronary vascular responses to stimulation of chemoreceptors and baroreceptors: evidence for reflex activation of vagal cholinergic innervation.


Improved method of mass-screening for galactosemia.


The source of aromatic ketoacids in tyrosinaemia and phenylketonuria.


Meclofenoxate after eight years.

Meclofenoxate after eight years.


T and B lymphocytes in New Zealand black mice. An analysis of the theta, TL and MBLA markers.


The epileptogenic action of Na-folate in the rat.


Clonal differences in glutamine synthetase activity of hepatoma cells. Effects of glutamine and dexamethasone.


Annual convention, 1972.

Annual convention, 1972.


Hypersensitive reactions to immunization innoculations and antecedent psychological vulnerability.


The origin of the blood cells.

The origin of the blood cells.


Clinical trial of intravenous hexoprenaline in asthma.


Double-blind trial of a new bronchodilator in asthmatic children.


Redox state of pyridine nucleotides in renal response to aldosterone.


Mechanism of thyroid hormone formation.

Mechanism of thyroid hormone formation.


Drug action of peripheral vascular system.


Clinical trials with amphetamine-blocking drugs.


Prostaglandins.

Prostaglandins.


Report of the 27th International Psycho-analytical Congress.


Some aspects of the mechanism of action of various stimulant amphetamine analogues.


Cell movements in morphogenesis of hydroid polypes.


The effect of prostaglandin F 2   on the utilization of (6- 14 C)glucose by the superovulated rat ovary.


Delayed onset of unilateral cryptorchidism in pigs.


The utilization of dental services by families at the Hill Health Center.


A new method of teamwork in family medicine in Israel with the participation of nurses as physician's assistants.


Nursing in a health maintenance organization. Report on the Harvard Community Health Plan.


Growth rate of an allogeneic mouse tumour in antigenically pretreated hosts as a function of the dose of cell-free H-2 antigens used.


Some observations on the T, Tn and Sda antigens and the antibodies that define them.


Immunosuppression of subacute skin allograft rejection in the newt, Diemictylus v. dorsalis, by alloantigenic pretreatment with kidney and liver implants.


Amoxycillin: a new semi-synthetic penicillin. Amoxycillin (alpha-amino-p-hydroxybenzylpenicillin) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin. Penicillin-sensitive strains of staphylococci, streptococci, and pneumococci were sensitive to concentrations of 0.1 mug or less of amoxycillin/ml. Strains of Haemophilus influenzae were inhibited by a level of 0.5 mug/ml, and most strains of Escherichia coli, Proteus mirabilis, Shigella sonnei, Salmonella species, and Streptococcus faecalis were sensitive to a concentration of 5 mug or less of amoxycillin/ml. Penicillinase-producing strains of Staphylococcus aureus and strains of Pseudomonas aeruginosa, indole-positive Proteus, Klebsiella, and Enterobacter were insensitive to amoxycillin. The new penicillin was bactericidal in activity, as with other penicillins, and its antibacterial activity was not reduced in the presence of serum. After oral administration to volunteer subjects amoxycillin produced serum concentrations twice as high as those obtained with similar doses of ampicillin, and the penicillin was recovered unchanged in high concentrations in the urine. The absorption of amoxycillin was not greatly influenced by food, and administration of probenecid resulted in increased and more prolonged concentrations of amoxycillin in serum.


Biochemical changes in rat liver in response to treatment with drugs and other agents. IV.


Potentiation of insulin secretion in vitro by serotonin antagonists.


A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.


Co-enzyme dependence of retinol dehydrogenase in the retina of adult rat.


Inactivation, stabilization and some properties of ATP: glutamine synthetase adenylyltransferase from Escherichia coli B.


The immunobiology of tissue transplantation.


The immunobiology of tooth transplantations.


The effect of meclofenamic acid on plasma uric acid levels.


Centrophenoxine and chlormethiazol in the treatment of delirium tremens.


Prothidryl--combination of antihistaminic bromadryl and thymoleptic prothiaden. Pharmacological study.


To the antineurotic effect of prothidryl and its tolerance.


The effect of centrophenoxine, lithium and imipramine on the metabolism of rat brain cortex slices in vitro.


Propericiazin, diazepam, chlorpromazine and placebo in a doubleblind trial in pedopsychiatric therapy.


Correlation between glucocorticoid binding to specific liver cytosol receptors and enzyme induction in vivo.


Purification of alditol: NADP oxidoreductase from human placenta.


A glutamate-dependent phenotype in E. coli K12: the result of two mutations.


The cardiomyopathies.

The cardiomyopathies.


Evaluation of  -adrenergic blocking agents in presence of adrenergic tone.


Clinical, electrocardiographic, and haemodynamic effects of digitalis (ouabain) in angina pectoris.


Visual discrimination learning in normal and tectal-ablated nurse sharks (Ginglymostoma cirratum).


New insights into the organization of the shark brain.


In vitro binding of human C-reactive protein by some pathogenic bacteria and zymosan.


Sodium-linked urea transport by the renal tubule of the spiny dogfish Squalus acanthias.


The structure and morphologic relations of rods and cones in the retina of the spiny dogfish, Squalus.


The electrophysiological response of the dogfish gastric mucosa to extracellular potassium.


The effect of foreign compounds on elasmobranchs and the effect of elasmobranchs on foreign compounds.


Prediction of the distribution of methotrexate in the sting rays Dasyatidae sabrina and sayi by use of a model developed in mice.


The blood to tissue distribution of various polar materials in the dogfish, Squalus acanthias.


The fate of p,p'-DDT (2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane) in the dogfish, Squalus acathias.


Physiologic and pharmacologic aspects of barbiturates in elasmobranchs.


Contributions to the pharmacology of quinaldine (uptake and distribution in the shark and comparative studies).


Comparative hemostasis: studies on elasmobranchs.


Studies on the mild reduction of shark polymeric and monomeric IgM.


Binding properties of shark immunoglobulins.


Toxic effect of ammonia dissolved in sea water.


A model for passive urea reabsorption in the elasmobranch kidney.


Rectal gland secretion in the stingray, Dasyatis sabina.


Comparison of some parameters of serum and uterine fluid of pregnant, viviparous sharks (Carcharhinus leucas) and serum of their near-term young.


Corticosteroids in plasma of elasmobranchs.


Intrarenal control of urea reabsorption by renal tubules of the marine elasmobranch, Squalus acanthias.


Biosynthesis of trimethylamine oxide in the nurse shark, Ginglymostoma cirratum.


Fine structure of elasmobranch arteries, capillaries and veins in the spiny dogfish, Squalus acanthias.


Morphological correlates of fluid transport in the isolated intestine of Squalus.


Brain-barrier systems in sharks.

Brain-barrier systems in sharks.


Acoustic attraction of Pacific reef sharks: effect of pulse intermittency and variability.


Klinotaxis and rheotaxis in orientation of sharks toward chemical stimuli.


The clasper-siphon sac mechanism in Squalus acanthias and Mustelus canis.


Necrotizing angiopathic neuropathy. Three-dimensional morphology of fiber degeneration related to sites of occluded vessels.


A familial spinal cord disorder with hyperglycinemia.


Oral health of Australian aborigines: survey methods and prevalence of dental caries.


A translational control mechanism in mammalian protein synthesis modulated by cyclic adenosine monophosphate. Translational control of tyrosine aminotransferase synthesis in neonatal rat liver.


Biosynthesis of methylheptadecanes in Anabaena variabilis. In vitro incorporation of S-(methyl- 14 C)adenosylmethionine.


Effects of dopamine on the conductance of perfused vascular beds of the chloralosed cat. 1. Dopamine produced vasoconstriction followed by secondary vasodilatation in the perfused cat hindquarters and splanchnic region. Low doses produced only vasodilatation in the splanchnic region.2. Phenoxybenzamine abolished, while despiramine and cocaine potentiated, the vasoconstrictor and secondary dilator actions of dopamine.3. After phenoxybenzamine, dopamine produced only vasodilatation in both the hindquarters and splanchnic region, being more effective in the latter.4. Haloperidol, but not propranolol, atropine or mepyramine, antagonized dopamine-induced vasodilatation.5. Dopamine differs from other catecholamines in that, while its cardiac effects are mediated by a beta-adrenoceptive mechanism, its vasodilator effects are not.6. The results support the concept of a specific receptor mediating dopamine vasodilatation.


Studies on the possible role of brain histamine in behaviour. 1. The possible role of brain histamine in behavioural performance was studied in rats using thirst-induced water consumption, continuous (Sidman) avoidance, and reinforcement withdrawal test systems.2. Parenteral administration of a variety of antihistamines to rats decreased thirst-induced water consumption; this effect could be antagonized by administration of histamine directly into the brain by a ventricular cannula.3. When intraventricular doses of histamine were administered to rats at weekly intervals, an adaptation was seen in the effects of the amine on continuous avoidance behaviour. With succeeding doses, the initial period of depression of avoidance responding was shortened and the subsequent rebound stimulation disappeared.4. The results support the hypothesis that histamine in the brain is involved in several behavioural phenomena.


Humoral autoregulation of blood flow and blood pressure.


Anesthetic management of patients treated with antihypertensive agents of levodopa.


Studies on the mechanism of the L-3,4-dihydroxyphenylalanine-induced decrease in tyrosine hydroxylase activity.


The role of intercostal block and three general anesthetic agents as predisposing factors to postoperative pulmonary problems.


Histamine methyltransferase: inhibition and potentiation by antihistamines.


Altered microsome function during acute thioacetamide poisoning.


Anesthetic management problems posed by therapeutic advances: 3. Beta-adrenergic blocking drugs.


Hepatic organelle interaction. I. Spectral investigation during drug biotransformation.


Hepatic organelle interaction. II. Effect of tricarboxylic acid cycle intermediates on N-demethylation and hydroxylation reactions in rat liver.


Transmission of Australia Au(1) antigen by Culex mosquitoes.


Fluoridation in Cudahy. Five-year evaluation.


Effects of thyroxine, oxyphenbutazone and imipramine on an inflammatory graft-versus-host reaction in chicks.


Inmate responses to lengthy death row confinement.


Autonomic disturbance at onset of acute myocardial infarction. Of 74 patients seen within 30 minutes of the onset of acute myocardial infarction 68 (92%) had signs of autonomic imbalance. Excessive vagal activity was evident in 41 (55%) and there was sympathetic overactivity in 27 (36%). The high incidence of sudden death in the acute phase of a coronary attack probably results from the electrical imbalance caused by autonomic disturbance. This disturbance must therefore be taken into account in any prophylactic regimen against the lethal early ventricular dysrhythmias.


The correlation between bioelectrical and morphogenetic polarity during regeneration in Tubularia.


Regulatory mechanisms in the induction of glutamine synthetase in the embryonic retina: immunochemical studies.


Corticosteroid-binding globulin in the rat: isolation and studies of its influence on cortisol action in vivo.


Pyridine nucleotides in normal and nicotinamide depleted adrenal tumor cell cultures.


Rectal biopsy as a diagnostic aid in periarteritis nodosa.


Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter.


The next step; presidential address.

The next step; presidential address.


Hexokinase acceptor theory of insulin action. New evidence.


Increased release of xylocholine (TM10) from guinea-pig vas deferens treated with amphetamine sulphate.


Effect of neuroleptic drugs on central catecholamine turnover assessed using tyrosine- and dopamine- -hydroxylase inhibitors.


The effects of corticosteroids on the reduction of  -adrenoceptor blockade produced by  -adrenoceptor blocking agents.


The influence of replacement of the N-ethyl group by the cyanoethyl group on the absorption, distribution and metabolism of (plus or minus)-ethylamphetamine in man.


Automatic weight-control in a rotary tabletting machine.


Partition coefficients of salicylic acid between water and the micelles of some non-ionic surfactants.


The uptake by Escherichia coli and growth inhibitory properties of benzyl alcohol and phenethyl alcohol.


Relation between cation and lipid content of cell walls of Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella aerogenes and their sensitivity to polymyxin B and other antibacterial agents.


The sterols and tetracyclic triterpenoids of Digitalis purpurea L. seeds.


Scopolia lurida, Dunal; the structure of the leaves and stem.


Estimation of phenacetin and paracetamol in plasma and urine by gas-liquid chromatography.


N-oxidation--an important route in the metabolism of methadone in man.


Effect of tranylcypromine sulphate on the metabolism of ( 14 C)tyramine in vivo in the rat.


Preliminary observations on the metabolism of (1- 14 C)tyramine in man.


Sensitization procedures and the blood sugar concentration.


-Aminobutyrylcholine and central inhibition.


Sleep-inducing effects of L-tryptophan.

Sleep-inducing effects of L-tryptophan.


A method of characterizing tablet formation.


Inhibition of glucose absorption by prostaglandins E 1 , E 2  and F 2  .


Aggregation of (+)-propoxyphene hydrochloride in aqueous solution: circular dichroism measurements.


The effects of microfine calcium carbonate on the flow properties of granules and their relevance to tabletting.


Cannabis sativa induces "winning" behaviour in previously "loser" rats.


An improved valve device for the continuous measurement of arterial blood pressure in the conscious unrestrained cat.


Evaluation of infant health care by a nurse practitioner.


The costs of training and the income generation potential of pediatric nurse practitioners.


Allied health workers in pediatrics.

Allied health workers in pediatrics.


Bone marrow transplantation incompatibility modified by F 1  graft inocula.


Editorial: accreditation and national certification of P.A. programs.


Cardiovascular and central nervous system effects of parenterally administered single doses of procarbazine (NSC-77,213).


Morphometric data on the ultrastructure of the pleomorphic bloodforms of Trypanosoma brucei, Plimmer and Bradford, 1899.


Method for preparing NAD labeled with  3 H of high specific radioactivity in the 4-nicotinamide position.


Further studies on corticosteroidogenesis. IX. Energy-linked transhydrogenase in rat adrenal gland mitochondria.


Hyperkinetic circulatory disorder after closure of persistent ductus arteriosus.


Hereditary prolongation of QT interval.

Hereditary prolongation of QT interval.


Effects of gamma-hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes. 1. Convulsant and anticonvulsant effects of gamma-hydroxybutyrate (GHB) have been studied in chicks.2. When administered alone, GHB produced weak myoclonic seizures accompanied by electrocortical synchrony and spikes.3. GHB was found to protect chicks against leptazol- and picrotoxin-induced seizures. A slight potentiation of strychnine-induced seizures was evident.


Comparative study of six  -adrenoceptive antagonists on airway resistance and heart rate in the guinea-pig. 1. The effects of six beta-adrenoceptive antagonists [(+/-)-propranolol, (+)-propranolol, (+/-)-sotalol, (+/-)-practolol, (+/-)-pindolol and (+/-)-procinolol] were studied on airway resistance and heart rate in guinea-pigs and dose-response curves constructed.2. All beta-adrenoceptive antagonists decreased heart rate and increased airway resistance. A significant correlation was found between the increase in airway resistance and the degree of bradycardia induced by all drugs except practolol. The orders of activity of the six drugs in inducing significant variations of the two parameters were respectively, for airway resistance: (+/-)-procinolol>(+/-)-pindolol>(+/-)-propranolol>(+/-)-sotalol>(+)-propranolol>(+/-)-practolol, and for heart rate: (+/-)-pindolol>(+/-)-procinolol>(+/-)-propranolol>(+/-)-sotalol>(+)-propranolol>(+/-)-practolol.3. (+/-)-Sotalol, (+/-)-pindolol and (+/-)-procinolol-induced changes in airway resistance and heart rate reached plateau values, which were not modified by increasing the dose. Since sotalol and procinolol have only very weak partial agonist and cardiac depressant properties, it appears that these changes can mainly be accounted for by the suppression of sympathetic tone. It is probable that this is also the case with pindolol.4. On the other hand, (+/-)-propranolol and (+)-propranolol induced dose-related changes in airway resistance and heart rate. Thus, a direct and non-specific effect of both drugs on the bronchial muscle, similar to that observed on the heart appears to be implicated, together with sympathetic tone suppression in these variations.5. (+/-)-Practolol-induced effects on airway resistance and heart rate were different from those observed with the five other beta-adrenoceptive antagonists.


Isolation and identification of pharmacologically active amino acids in skin and their structure-activity relationship on the guinea-pig ileum. 1. Aqueous extracts of stratum corneum were found to cause histamine-like contractions of the guinea-pig ileum which were not antagonized by mepyramine, atropine or bromolysergic acid diethylamide.2. The compounds responsible for this contraction were isolated by chromatography and shown to be common amino acids, particularly L-serine and L-alanine which occur in abundance in the stratum corneum.3. Amino acid analogues were assayed on the guinea-pig ileum against alanine as standard. With the exception of gamma-amino butyric acid and L-alanine benzyl ester all analogues which had appreciable activity gave dose-response curves parallel to L-alanine.4. The response to L-alanine benzyl ester was abolished by mepyramine and this analogue appears to be a partial agonist on the histamine receptor.5. The effects of substitution on the equipotent molar ratios of amino acid analogues indicate that all four chemical groups attached to the alpha-carbon of L-alanine interact with the receptor.6. Our results suggest that the guinea-pig ileum contains an L-alpha-amino acid receptor.


The action of propranolol on the dog heart.


Negative inotropic responses of the isolated heart of the rat to isoprenaline. The isolated heart of the rat perfused at 38 degrees C responded to isoprenaline with an initial positive inotropism followed by a bi-phasic negative inotropic effect. The latter was associated with the simultaneous biphasic rate increase. On reduction of the perfusion temperature to 20 degrees C, isoprenaline no longer increased the rate but a negative inotropic response remained. Blockade of this by practolol suggested that it was mediated via beta(1)-adrenoceptors.


Psychological adjustment and response to open-heart surgery: some methodological considerations.


Effects of the inhibition of noradrenaline uptake and synthesis on the maintenance of the response to continuous nerve stimulation in the central artery of the rabbit ear. 1. The central artery of the rabbit ear was perfused through its lumen in vitro, with a constant pressure technique, and stimulated continuously via its periarterial sympathetic nerves at the physiological frequency of 5 Hz.2. The vasoconstrictor response, which led initially to an almost complete cessation of intraluminal flow, deteriorated steadily over a period of hours. The involvement of presynaptic mechanisms in this effect was indicated by the finding that noradrenaline, administered extraluminally, produced a similar response before the onset of continuous stimulation and at a late stage when the constriction had decreased markedly. In addition, the noradrenaline precursor DOPA, restored the depressed responses towards their original values, indicating that failure involved depletion of mediator for release.3. Responses to continuous stimulation declined significantly faster after inhibition of tyrosine hydroxylase with alpha-methyl-p-tyrosine. However, inhibition of the uptake of noradrenaline with cocaine did not enhance the decline of the response, even when the sensitization produced by the compound was taken into account.4. It is concluded that synthesis, along with the mobilization of stored mediator, rather than uptake and re-use of noradrenaline maintain the effector response in the central artery of the rabbit ear stimulated continuously at a frequency within the physiological range.


Genital function in males with vesical exstrophy and epispadias.


The presence of  -adrenoceptors in the guinea-pig seminal vesicle. 1. The preparation of longitudinal smooth muscle strips from guinea-pig seminal vesicles is described.2. Isoprenaline and salbutamol inhibited contractions produced by parasympathomimetic agents.3. The inhibitory action of isoprenaline was blocked by low concentrations of propranolol and butoxamine. It was concluded that beta(2)-adrenoceptors were present in the tissue.4. The inhibitory action of isoprenaline was not apparent when adrenaline, noradrenaline, hypogastric nerve or transmural stimulation were used to contract the tissue.


Beta-adrenergic blocking activity and haemodynamic effects in man of Kö 1313, a new beta-adrenergic antagonist.


The evaluation of histamine antagonists in man.


Effects of a new stimulator of beta-receptors, terbutaline, on ventilatory capacity, lung resistance, heart rate and blood pressure.


The properties of tablets manufactured on an automatically-controlled rotary machine.


Enhanced migration of the ionized forms of acidic drugs from water into chloroform in the presence of phospholipids.


X-ray analysis of Th 1165a and salbutamol.


The absorption, metabolism and elimination of (plus minus)-N-(2-benzoyloxyethyl)norfenfluramine (JP992) in man.


Desoxyisoprenaline: an adrenoceptor stimulating and blocking agent.


Comparative investigation of inhibitors of extracerebral dopa decarboxylase in man and rats.


Adaptation to the natriuretic actions of hydrochlorothiazide, frusemide and amiloride, by rats.


Effect of  -adrenoceptor antagonists on the decline of the chronotropic response to isoprenaline.


Responses of blood vessels to various amines applied by microiontophoresis.


Analogues and homologues of atropine: anti-acetylcholine activities.


Cutaneous reaction to prostaglandins E 1 ,E 2  and F 2   in the bovine.


Isomeric substrate studies with normal and atypical serum cholinesterase.


Effect of disulfiram and ascorbic acid on catecholamine content in rat brain.


[Protection against phenylisothiocyanate by various steroids, phenobarbitone and diphenylhydantoin].


Experimental gastric ulcers and stomach tissue pepsin activity in the rat.


The dextro-isomer of noradrenaline as a false transmitter.


Effect of phenylbutazone breakdown products on drug metabolism assay.


Aggression in rats treated with dopa and 6-hydroxydopamine.


On the neuromuscular blocking action of succinylmonocholine in the rat.


A simple equation to estimate the fraction of drug remaining in the body after an intravenous injection.


A rapid photographic method for the determination of vein-islet number and stomatal index of leaves.


Sulfhydryl requirement for alpha adrenergic receptor activity and melanophore stimulating hormone (MSH) action on melanophores.


Systemic therapeutic agents and glaucoma.


Three cases of 'restless legs' or 'Ekbom's syndrome' as seen in general practice.


Partial purification and some properties of guinea pig kidney 17 -hydroxy-C 19  steroid dehydrogenase.


Heterogeneity of guinea pig kidney 17 -hydroxy-C- 19 -steroid dehydrogenase activity observed by disc gel electrophoresis.


Treatment of Wolff-Parkinson-White syndrome.


Convulsive activity in garter snakes.

Convulsive activity in garter snakes.


Reduced pyridine nucleotide binding to beef liver and dogfish liver glutamate dehydrogenases.


Evidence for translational regulation of specific enzyme synthesis by N 6 , O 2' -dibutyryl cyclic AMP in hepatoma cell cultures.


Kinetic studies on substrate-enzyme interaction in the adrenal cholesterol side-chain cleavage system.


Specific synthesis of 1-(5-glutamyl)-2-methylhydrazine by glutamine synthetase.


A possible role for transhydrogenation in side-chain cleavage of cholesterol.


Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression.


Mechanism of anti-arrhythmic action of propranolol.


Comparative evaluation of dopamine and other adrenergic amines in some isolated organs.


Effect of two new beta-blocking drugs on heart rate and blood pressure during passive tilting in man.


The glutamic acid dehydrogenase of adult female Ascaris suum.


The effects of ganglionic blockade on tracheobronchial muscle in fetal and newborn lambs.


The serotonin-catecholamine-dream bicycle: a clinical study.


The metabolism in vivo and in vitro of 3-oxo-7 -hydroxychol-4-enoic acid-24- 14 C as an intermediate of chenodeoxycholic acid biogenesis.


The inheritance of cryptorchism in a small crossbed flock of sheep.


Glucocorticoid receptors: relations between steroid binding and biological effects.


Immunologic reconstititution of a patient with combined immunodeficiency disease.


The autonomic nervous system and some aspects of the use of autonomic drugs in children. I.


Pediatric cardiology: a new role for the pediatric assistant.


A new sterol from an alcyonarian.

A new sterol from an alcyonarian.


An important distinction.

An important distinction.


Obsessions of infanticide. A review of 42 cases.


Absorption, metabolism, and excretion of salicylazosulfapyridine in man.


Flucloxacillin: a new semisynthetic isoxazolyl penicillin.


Effects of dream loss on waking behaviors.


An anomalous ESR signal from rapidly frozn liver microsomes.


The value of  G degrees for the hydrolysis of ATP.


Attempted suicide and social class. I.

Attempted suicide and social class. I.


Thiopental activation and spontaneous sleep and dream patterns of resistant schizophrenics.


Enzymic synthesis of 6-deoxy- -D-glucopyranosyl  -D-glucopyranoside and  -D-xylopyranosyl  -D-glucopyranoside.


Experience with the use of doxapram in the treatment of respiratory failure.


3 -reduction of 5 -dihydrotestosterone by rat ventral prostate.


Stability in zoological nomenclature.

Stability in zoological nomenclature.


Decrease and loss of vascular  -adrenergic response in hindlimbs of dogs with chronic aortic coarctation.


Alterations of fatty acid metabolism in liver cells of hyperlipaemic old rats.


The influence of the wives on the treatment outcome of alcoholics: a follow-up study at two years.


Interpersonal patterns in alcoholic marriages.


Independent study: impossible dream or intriguing challenge?


Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase.


Individualizing instruction in nursing.

Individualizing instruction in nursing.


Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines.


On the suitability of aequorin as an intracellular calcium detector.


Biological function of the ammonia-induced inactivation of glutamine synthetase in Escherichia coli.


Theory of antimotion sickness drug mechanisms.


Mosquito transmission of Plasmodium vivax from night monkey to night monkey.


Drugs and respiratory control.

Drugs and respiratory control.


Strain differences in behavior and brain tyrosine hydroxylase activity.


MMPI performance in chronic medical illness: the use of computer-derived interpretations.


Tyrosine hydroxylase in human adrenal glands and human pheochromocytoma.


Personality attributes of the young, nonaddicted drug abuser.


Personality characteristics and drug of choice.


Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex.


Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.


The binding of desialylated glycoproteins by plasma membranes of rat liver. Development of a quantitative inhibition assay.


The trend of dental caries in Korea.

The trend of dental caries in Korea.


Derivatives of 10,11-dihydro-5H-dibenzo(a,d)cycloheptene and related compounds. 6. Aminoalkyl derivatives of the aza isosteres.


Biological properties of carrageenan.

Biological properties of carrageenan.


Studies on enzymes from parasitic helminths. II. Purification and properties of malic enzyme from the tapeworm, Hymenolepis diminuta.


Evidences for the involvement of a histidine residue in the binding of the substrate to the 6-phosphogluconate dehydrogenase.


Aminoaldehyde dehydrogenases from a Pseudomonas species grown on polyamines.


Digital computer prediction of the optimal anaesthetic inspired concentration.


A look at the dental health of school children in Richmond, Indiana.


Abnormal kinetics of the redox reactions of intrinsic mitochondrial pyridine nucleotides in hypothyroidism.


Microphotometric determination of enzyme activity in single cells in cryostat sections. I. Application of the gel film technique to microphotometry and studies on the intralobular distribution of succinate dehydrogenase and lactate dehydrogenase activities in rat liver.


Intravenously administered doxycycline in urological and surgical infections.


Graft versus leukemia for "cell cure" of long-passage AKR leukemia after chemoradiotherapy.


Myocardial metabolism and dynamics after practolol during light halothane anaesthesia.


-Adrenergic blocking agents of the chromone and xanthone groups. II. Propranolol type derivatives.


Role of brain amines in learning associated with "amphetamine-state".


Thymic dysplasia associated with lymphopenia.


Enzyme histochemical studies on wound healing in rat liver.


Studies on some aspects of peroxidase from submaxillary gland.


Peripheral ischemia and collagen disease: clinical manifestations, diagnosis, and treatment.


Ion exchange method for the separation and spectrophotometrie determination of some sympathomimetic amines, antihistamines, and phenothiazines in pharmaceuticals.


Tyrosine hydroxylase activity in neuroblastoma and human adrenal gland.


The problem of behaviour at the cellular level (cytoethology).


The prevention and treatment of hay fever.


Meclastine in hay fever.

Meclastine in hay fever.


Clinical and rehabilitation regime in patients with chronic obstructive pulmonary diseases.


Recent investigations on the nature of sterol intermediates in the biosynthesis of cholesterol.


Suggestions for a mathematical model of a pathological neuron with spontaneous repetitive discharges.


Simulation of normal MMPI profiles by repressors and sensitizers.


Drug abusers and their clinic-patient counterparts: a comparison of personality dimensions.


Cardiac beta-adrenergic receptors and coronary hemodynamics in the conscious dog during hypoxic hypoxia.


Renal transplantation in rabbits. VI. Immunofluorescent study of IgG deposits in renal allografts.


Clinical trial of doxapram hydrochloride in the resuscitation of the newborn.


Effects of some sympathomimetic drugs and their antagonists on afterdischarges elicited in chronically isolated slabs of cerebral cortex. 1. The role of sympathomimetic agents in the maintenance and termination of induced cortical epileptiform activity was studied in chronically neuronally isolated slabs of cerebral cortex in the suprasylvian gyrus of unanaesthetized, unrestrained cats.2. The administration of the sympathomimetic agents (+)-amphetamine, methamphetamine, tyramine, and ephedrine resulted in a highly significant decrease in the duration of epileptiform afterdischarge (EADs).3. The alpha-adrenoceptor blocking drugs phenoxybenzamine, phentolamine and tolazoline did not significantly alter the duration of EADs but prevented the decrease in duration of EADs produced by the sympathomimetic drugs.4. The effect of atropine and arecoline on the duration of EADs, previously described, were not modified by the alpha-adrenoceptor blocking drugs, but atropine prevented and reversed the inhibitory action of amphetamine.5. It is suggested that (1) in the chronically neuronally isolated cortical slab there is normally no spontaneous adrenergic activity, (2) a cortical, cholinergic inhibitory mechanism, previously described, is modulated by ascending adrenergic influences, (3) adrenergic cholinergic linkages might be arranged in the cortex in an alternating network, as proposed by Feldberg.


Effect of reserpine on the activity of adrenal enzymes involved in the synthesis of adrenaline. 1. After administration of reserpine to rats, the tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) activity in their adrenal glands was found to be increased under in vitro conditions.2. The increase in TH activity occurred at 12-18 h after reserpine whereas the PNMT activity increased at 30 hours. Unlike the TH, the increase in PNMT activity did not appear to be neuronally mediated since ganglion blockade by chlorisondamine failed to antagonize the reserpine-induced increase in PNMT activity. The increase in PNMT activity may be a response to increased utilization of catecholamines.3. Hypophysectomy resulted in a diminution of the activities of both enzymes; the activity of TH, but not of PNMT, could be partially restored by reserpine. ACTH restored the activities of both enzymes almost to normal.4. The differential effect of reserpine suggests that the activities of these two enzymes are controlled by different mechanisms.


Effect of mescaline on single cortical neurones. The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The correlation between the effects of mescaline and 5-HT, however, was less consistent. The beta-adrenoceptor blocking agent MJ-1999 and the 5-HT antagonist methysergide were both effective in antagonizing mescaline responses.


Training of military enlisted paramedical personnel for greater use in civilian and military practice of surgery.


Oxidation--reduction properties of phytoflavin, a flavoprotein from blue-green algae.


A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase.


Emotions and the skin: the conditioning of scratch responses in cases of atopic dermatitis.


Tetracycline effects on statolith and nematocyst differentiation in Aurelia.


Antitumor activity in mice of four coelenterate extracts.


Potential antihistamines with increased receptor specificity.


New compounds: amides derived from ((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl) thio)acetic acid.


Glutamic acid release in the isolated supra oral sphincter preparation of the sea anemone Actinia equina.


Eating caused by 6-hydroxydopamine-induced release of noradrenaline in the diencephalon of the rat. 1. Although it is well established that exogenous noradrenaline injected into the diencephalon causes the satiated rat to eat, it is not known whether eating may be induced by release of endogenous diencephalic noradrenaline. In the present experiment 6-hydroxydopamine was injected into the diencephalon of the rat to release catecholamines and produce degeneration of catecholamine-containing neurones.2. Injection into the preoptic area of 0.01-16.0 mug of 6-hydroxydopamine caused satiated rats to eat.3. All doses of 6-hydroxydopamine above 0.01 mug produced long-lasting partial depletion of noradrenaline and dopamine in the region of the brain composed of septum, preoptic area and hypothalamus.4. Repeated injections of 8 mug 6-hydroxydopamine at intervals of several days caused progressively less eating.5. Eating in response to 6-hydroxydopamine was inhibited by pre-treatment with desmethylimipramine, or by pre-treatment with the adrenergic blocking agents phentolamine or MJ-1999.6. Water intake after 6-hydroxydopamine was reduced by pre-treatment with desmethylimipramine or MJ-1999 but was enhanced after pre-treatment with phentolamine.7. It is concluded that release of diencephalic catecholamines by injection of 6-hydroxydopamine causes eating in rats and that the catecholamine responsible for eliciting eating is noradrenaline.


Aldehyde derivatives of indoleamines and the enhancement of their binding onto brain macromolecules by pentobarbital and acetaldehyde.


Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits.


The prevalence of dental caries in Godhavn and Scoresbysund districts, Greenland.


The appropriateness of analysis of variance to the statistical analyses of dental clinical trials.


Histochemical study of mandibular joint adaptation in experimental posterior mandibular displacement in the rat.


Fluoridation in Tamworth 1963-1971.

Fluoridation in Tamworth 1963-1971.


Infective factors in exacerbations of bronchitis and asthma. Infections of the respiratory tract were studied in a group of families each containing a patient with chronic bronchitis or with asthma. A wide variety of infective agents may be associated with exacerbations in susceptible subjects, but the types of organism to which patients are most at risk differ according to the family structure. Exacerbations in the susceptible subject are more likely to be related to viral infections when the family contains children than when it does not.Two patients with asthma experienced frequent respiratory infections, many of which provoked attacks of asthma.


Specific neurohistory comes of age: a look back and a lood forward. The Jonas S. Friedenwald memorial lecture.


Acid phosphatase profile during the life-span of the mosquito.


Congenital absence of the fibula and craniosynostosis in sibs.


The effect of unilateral orchidectomy and unilateral cryptorchidism on sperm output in the rat.


An early differential effect of cadmium on the scrotal and contralateral cryptorchid testes in the rat.


Serum and salivary antibodies to glucosyltransferase in dental caries in man.


Vasodilator response to epinephrine in denervated muscle: role of pulse pressure.


Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures.


Non-random distributions of caries attacks among mesial and distal surfaces of human permanent maxillary incisors.


The prevalence of dental caries, enamel opacities and enamel hypoplasia in Ugandans.


Hematologic responses to hypobaric hyperoxia.


Day and full-time psychiatric treatment: a controlled comparison.


Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination.


Root surface caries in Lufa, New Guinea. 1. Clinical observations.


The New Zealand School Dental Service: lesson in radical conservatism.


Splint technique for dental-alveolar trauma.


Increased vascular permeability induced by staphylococcal alpha-toxin.


Homology in capsular transformation reactions in Pneumococcus.


Erythrocyte glutathione reductase--a measure of riboflavin nutritional status.


Mechanisms of synaptic transmission.

Mechanisms of synaptic transmission.


Efficiency of the glycolytic pathway in erythrocytes of children with Down's syndrome.


Fluid ear.

Fluid ear.


Nasal obstruction.

Nasal obstruction.


A common modality of action of simulated space stresses on the oxidative metabolism of ethylmorphine, aniline and p-nitroanisole by male rat liver.


A comparison of enzyme patterns in the granular and molecular layers of the rabbit cerebellar cortex.


Studies on the site of action of tolbutamide in the lipolytic system.


Bidirectional effects of interaction between parental thymocytes and F1 spleen cells in the production of graft vs host splenomegaly.


A new medical practice act for Indiana.

A new medical practice act for Indiana.


The urological assistant: a preliminary report.


Capillary tube migration of peritoneal exudate cells from animals affected by footpad-induced graft-versus-host reaction.


Effect of phenobarbital on hepatic transport and excretion of  131 I-rose bengal in children with cholestasis.


Separation and characterization of long-chain alcohol dehydrogenase isoenzymes from Pseudomonas aeruginosa.


Electrophoretic migration and redox behavior of malate dehydrogenases from cell suspension cultures of tobacco.


Structural studies on pneumococcus type II capsular polysaccharide.


Drug-induced porphyrin biosynthesis. VII. Species, sex, and developmental differences in the generation of experimental porphyria.


Regional development of catecholamine biosynthesis in rat brain.


Tyrosine hydroxylation in the rat striatum in vitro and in vivo after nigral lesion and chlorpromazine treatment.


The effect of dimorpholamine on crayfish neuromuscular junction.


Effect of the stimulation of afferent fibers in Hering's nerve on the blood flow and resistance in the coronary vessels of dogs.


Platelet adhesion in the rabbit abdominal aorta following the removal of endothelium with EDTA.


Role of DNA and specific cytoplasmic receptors in glucocorticoid action. Glucocorticoids induce tyrosine aminotransferase (EC 2.6.1.5) synthesis in cultured rat hepatoma cells. These steroids penetrate the cell membrane and bind to specific cytoplasmic receptor proteins. The resulting complex binds to the nucleus. This nuclear binding has now been studied in a cell-free preparation. The reaction appears to require a temperature-dependent modification of the steroid-receptor complex. There is a fixed number of nuclear sites that are half saturated at a complex concentration of 6 to 24 x 10(-11) M. Treatment with deoxyribonuclease destroys nuclear-binding capacity. The complex also binds to purified HTC cell DNA with characteristics similar to the binding to isolated nuclei, and, as in intact cells, receptors complexed with an anti-inducer steroid bind very poorly to DNA. These data suggest that the nuclear sites for binding steroid-receptor complexes are on the DNA. Since the extent of complex binding to purified DNA exceeds that observed with isolated nuclei, chromosomal proteins may act to restrict binding to certain regions of the DNA. These studies suggest that steroid hormones stimulate the synthesis of specific proteins by affecting the transcription of structural or regulatory genes.


The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species.


Observations upon the metabolism of fluorocitrate in rats.


Neurophysins and posterior pituitary hormones in the suiformes.


The reconstruction of a three-dimensional structure from projections and its application to electron microscopy. II. Direct methods.


The sites of the systemic insecticidal action of sulphaquinoxaline.


Clinico-pathologic conference. Scleroderma and an acute abdomen.


The activity of glucose-6-phosphate dehydrogenase in whole blood samples dried and stored on filter paper.


Drugs and folic acid absorption.

Drugs and folic acid absorption.


Selective beta adrenergic receptor blockade in the rat.


A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.


A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogs. 1. The haemodynamic effects of propranolol, practolol and 4-hydroxypropranolol have been compared in anaesthetized dogs both at free heart rates and at heart rates fixed by electrical pacing. All three drugs produced a fall in heart rate at the lowest dose of 0.09 mg/kg.2. Practolol caused less change in dP/dt, cardiac output and blood pressure than did propranolol. 4-Hydroxypropranolol had intermediate effects. Since the changes in dP/dt caused by these three drugs were still present when the heart rate was fixed by pacing, it is concluded that these were independent of changes in heart rate.3. The fact that practolol and 4-hydroxypropranolol cause less change in haemodynamic function than propranolol may be associated with the intrinsic sympathomimetic activity possessed by the first two of these drugs.


Assessment of the effectiveness of  -adrenoceptor blocking agents towards cardiac and bronchiolar responses of the pithed guinea-pig to electrical stimulation of the spinal outflow. 1. The responses of heart rate and resistance to lung inflation of the pithed guinea-pig on electrical stimulation of the thoracic spinal roots could be related to similar responses to injected catecholamines, such that dose-stimulus frequency relations could be plotted.2. The range of frequency of stimulation that was equi-effective with a dose range of injected catecholamines was higher for effects on air overflow than for heart rate. The slope of the relations for heart rate also differed from that for air overflow. These features may reflect a difference in effectiveness of the sympathetic innervation of heart and bronchial tree.3. Propranolol was equally effective in reducing the responses of heart rate and air overflow to injected noradrenaline. Practolol was somewhat more active against the effects of noradrenaline on air overflow than on heart rate, though equally active against the effects of isoprenaline.4. For the assessment of equivalent blockade of the effects of cord stimulation on heart rate and air overflow, frequency-ratios corresponding to a noradrenaline dose-ratio of 2 were derived from the slopes of the dose-frequency relations; for air overflow this value was approximately 2 and for heart rate approximately 1.4.5. When the doses required to produce these degrees of blockade were computed from the dose-response relations for blockade of the effects of cord stimulation by propranolol, they were found to be similar for effects on heart rate and air overflow. For practolol, the effective dose for block of heart rate increase was found to be lower than that for air overflow.


Effects of histamine, 5-hydroxytryptamine and bradykinin on the vascular system of isolated lungs of the guinea-pig and the influence of phenylbutazone on these effects. 1. In isolated lungs of the guinea-pig perfused through the pulmonary artery repeated doses of histamine progressively increased pulmonary arterial pressure and reduced fluctuations in tracheal pressure. Phenylbutazone almost completely abolished the effect of histamine on the arterial pressure and suppressed the progression of the effect on tracheal pressure.2. The effects of 5-hydroxytryptamine and bradykinin did not show such progression.3. The fractions of radioactivity remaining in the lungs after doses of (14)C-histamine did not differ significantly after successive doses. The outflow of radioactivity from previously loaded lungs was greatly increased by histamine, bradykinin and 5-hydroxytryptamine. This increase was not affected by papaverine.4. Successive doses of histamine, but not 5-hydroxytryptamine, produced a progressive increase in weight of the lungs and this effect was accompanied by a progressive increase in arterial pressure. Both effects were strongly suppressed by phenylbutazone.5. It is concluded that repeated administration of histamine causes an accumulation of fluid in the lungs probably mainly in the interstitial spaces, which results in an inhibition of the tracheal pressure fluctuations. Phenylbutazone prevents this effect by suppressing the vasoconstrictor action of histamine without affecting the increased vascular permeability.


Vectors of the 1969 yellow fever epidemic on the Jos Plateau, Nigeria. Entomological investigations of the possible mosquito vectors of the yellow fever epidemic on the Jos Plateau, Nigeria, were carried out between 27 October and 15 November 1969.Of the 5 species of Aedes (Stegomyia) collected, Ae. luteocephalus was the most abundant in human-bait captures. Ae. aegypti, Ae. africanus, and Ae. vittatus were collected in low numbers. The aegypti larval index in the areas investigated was very low and the species was not considered to be the primary vector in the epidemic. Ae. simpsoni larvae were abundant, but no adults were collected on human bait.Six isolates of 5 different arboviruses were obtained: yellow fever from damaged Stegomyia sp.; dengue 2 from damaged specimens, probably all Ae. luteocephalus; Zika (2 isolates) from Ae. luteocephalus; Bwamba from Anopheles funestus; and a Nyando-group virus from An. gambiae.


Comparative partial agonist activity of  -adrenoceptor antagonists. Inotropic dose-response curves were constructed for a series of beta-adrenoceptor antagonists, based on the inotropic responses of isolated dog trabecular muscles stimulated to contract at a regular rate. Propranolol exerted only a negative inotropic effect but K01366, LB46, oxprenolol and practolol all evoked a positive inotropic response, whether or not catecholamine-depleted muscles were used. The order of potency for this positive inotropic activity was K01366>LB46>oxprenolol>practolol. The duration of the positive inotropic response to the antagonists was more prolonged than that due to isoprenaline. Propranolol significantly reduced the positive inotropic response to K01366, LB46, oxprenolol and practolol.


Effect of morphine on tyrosine hydroxylase activity in mouse brain.


A dual action of histamine on guinea-pig lung vessels. 1. In isolated guinea-pig lungs perfused through the pulmonary artery, histamine caused a rise in perfusion pressure which was converted to a fall by a prior injection of mepyramine.2. Evidence is provided to show that at least part of the histamine effect was due to its direct action on pulmonary vascular tissue, and was largely independent of bronchomotor tone.3. Neither the pressor nor the depressor effects were modified by adrenoceptor blocking agents, phentolamine and propranolol, in doses which reversed or blocked the effects of noradrenaline, adrenaline or isoprenaline. The actions of histamine could therefore not be attributed to catecholamine release. The involvement of cholinergic mechanisms was also excluded since atropine failed to influence the histamine effects.4. It is suggested that the mepyramine-sensitive pressor, and the mepyramine-resistant depressor effects of histamine, were mediated by different receptors.5. It is proposed that a vasodilator action of histamine leading to a partial obstruction of the pulmonary airways could be part of the explanation for the relative ineffectiveness of mepyramine in blocking anaphylactic bronchoconstruction in the guinea-pig.


Spinal monoamines and the toxic interaction between monoamine oxidase inhibitors and tricyclic antidepressants.


Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons.


Emergency service improvement looks bright.


Presentations at AMA's 121st Annual Convention in June in San Francisco.


Synthesis of the hydroxyacids in lipid A of Pseudomonas aeruginosa.


Insect and scorpion sting.

Insect and scorpion sting.


The traumatized tooth.

The traumatized tooth.


The traumatized tooth: a synthesis.

The traumatized tooth: a synthesis.


Phagostimulation with blood platelets.

Phagostimulation with blood platelets.


Use and abuse of hemopoietic cell grafts in immune deficiency diseases.


Ecology of arboviruses in a Maryland freshwater swamp. I. Population dynamics and habitat distribution of potential mosquito vectors.


Ecology of arboviruses in a Maryland freshwater swamp. II. Blood feeding patterns of potential mosquito vectors.


Ecology of arboviruses in a Maryland freshwater swamp. 3. Vertebrate hosts.


Control of cerebral vasospasm by parenteral phenoxybenzamine.


Investigation of specificity in membrane breakage occurring during sonication of rough microsomal membranes.


Self-applied fluoride paste; effect on dental caries.


Isolation of plasma membrane and endoplasmic reticulum fragments from chick embryo fibroblasts.


Soluble cytochrome b 5  reductase from human erythrocytes.


Test of a method for estimating prevalence of DMFT.


Therapy of the respiratory distress syndrome.


Drug metabolism in the human fetus and newborn infant. This is a literature review designed to present the current state of knowledge regarding drug metabolism in the human fetus.  Since pharmaco-kinetic processes, i.e., absorption, distribution, metabolism, and excretion of drugs, largely determine the intensity and duration of drug action, such knowledge is useful as a guideline for drug therapy in the newborn period.  Both in vitro and in vivo studies dealing with pre-and postnatal drug metabolism in humans and animal species are reviewed.  The liver is considered the principle organ of drug metabolism.  Animal fetuses seem to have a negligible capacity to oxidize and conjugate drugs.  After birth the capacity increases at different rates, depending on the species, the type of reaction, and the type of drug.  There is, on the other hand, evidence that drug metabolism occurs in human fetuses.  The human fetal liver contains the drug-metabolizing enzyme system early in gestation.  The data which argues for and that arguing against the concept of low drug-oxidizing capacity in the newborn is summarized.  The old concepts regarding drug metabolism during the early part of life need reevaluation.


Dopamine: mediator of brain polysome disaggregation after L-dopa. The disaggregation of brain polysomes which is produced by giving large doses of (L)-dopa to rats is not reproduced by administering its metabolite, 3-O-methyldopa, by giving D-dopa, which also depletes the brain of S-adenosylmethionine but is not converted to catecholamines, or by giving the L-dopa after a decarboxylase inhibitor. Polysome disaggregation is potentiated by the prior administration of a monoamine oxidase inhibitor, indicating that formation of a catecholamine is an obligatory requirement. These observations suggest that the mechanism by which L-dopa disaggregates brain polysomes involves its conversion to dopamine within the majority of brain cells.