Differential GSR conditioning of true and false decisions.


Large scale normal adult base-rates for MMPI "privacy" items. I. Sexual attitudes and experiences.


The construction and validation of a Death Anxiety Scale.


Word association and ink blot responses as a function of instructional sets and psychopathology.


The Mosher Guilt Scale: theoretical formulation, research review and normative data.


An actuarial-experimental model of personality assessment.


Ego strength, social impression value of stimuli, and self-reference language.


Ideology and personality in war-peace attitudes.


Effects of some steroids on aggressive behaviour in mice and rats.


Studies with anti-lymphocytic antibody and antibody-fragments.


Differentiating male alcoholic from other psychiatric inpatients. Validity of the MacAndrew Scale.


Characteristics of alcoholics volunteering for lysergide treatment.


The estimation of oxidized and reduced NADP by an enzymic recycling system, with oxidized glutathione as hydrogen acceptor.


Pharmacology of a nicotinamido-methylaminopyrazolone (Ra 101).


Some toxicological aspects of a nicotinamide-methylaminopyrazolone (Ra 101).


Pharmacological actions of 1-(o-methoxyphenoxy)3-isopropylamino-2-propanol hydrochloride (S-D-1601), a new beta-blocking agent.


Potential vectors of Dirofilaria immitis.


Enhancement of the alpha receptor blocking action of N-ethoxycarbonyl-2--ethoxy-1,2-dihydroquinoline (EEDQ) by amines.


The W.M.A. statement on therapeutic abortion.


Further studies on the orthotopic transplantation of skeletal muscle.


Microbes and space flight.

Microbes and space flight.


Up the vocational stairs.

Up the vocational stairs.


Corticoid mediated increase in tyrosine-alpha-ketogluterate transaminase in the rat. A sensitive glucocorticoid assay.


In vitro adrenal mitochondrial 11 beta-hydroxylation following in vivo adrenal stimualtion or inhibition: enhanced substrate utilization.


The effect of alpha- and beta-adrenergic blocking agents on the renin response to hypoglycemia and epinephrine in dogs.


Interaction of drugs with autonomic nervous function and thermoregulation.


From gnats to cold sores.

From gnats to cold sores.


Report of the U.S.-Japan seminar on control of renin secretion.


Mechanism of pigeon liver malic enzyme. Formation of L-lactate from L-malate, and effects of modification of protein thiol groups on malic enzyme, oxalacetate, and pyruvate reductase activities.


Cholinergic and adrenergic receptors at sympathetic preganglionic nerve terminals.


Responses of the canine saphenous vascular bed to various biogenic and foreign substances.


Transmission in sympathetic ganglia.

Transmission in sympathetic ganglia.


Inhibition of RNA synthesis by alpha-amanitin in vivo.


Interaction of factors in the external environment upon the actions of psychotropic drugs in humans.


Drug environment interactions: acute hypoxia and chronic isolation.


Aerospace toxicology. II. Toxicological evaluation of materials associated with spacecraft.


On a new inhibitor of photosynthetic electron-transport in isolated chloroplasts.


Interferon action: effect on the formation of poxvirus specific polysomes and viral RNA.


Heterotransplantation of Ehrlich ascites tumor cells in rats pre-treated with cytostatics and antimetabolites.


Absolute configuration of carboxyacetylquercinic acid, chemical correlation of carboxyacetylquercinic acid with lanosterol.


Flurothyl convulsive therapy.

Flurothyl convulsive therapy.


The outstanding jet pilot.

The outstanding jet pilot.


A comparison of care given by family practitioners and psychiatrists in a teaching hospital psychiatric unit.


Eli Lilly Lecture: estrogen metabolism and action.


Defective testicular testosterone synthesis by the pseudohermaphrodite rat: an abnormality of 17 beta-hydroxysteroid dehydrogenase.


The effect of 4,4-dideuteration of nicotinamide adenine dinucleotide phosphate on steroid hydroxylation.


Traumatic rotational displacements of the distal tibial growth plate. A case report.


Endocytosis of thyroglobulin and release of thyroid hormone in mice by catecholamines and 5-hydroxytryptamine.


Reappraisal of biological ageing.

Reappraisal of biological ageing.


Investigations on the absorption of azulfidine.


An extended role for the nurse? To be or not to be.


Cryptorchism and homosexuality.

Cryptorchism and homosexuality.


Prognosis of permanent teeth involved in jaw fractures. A clinical and radiographic follow-up study.


Comparison of health appraisals by nurses and physicians.


Group psychotherapy for homosexual men by male-female cotherapists.


Emotions and the autonomic nervous system.


Binding of the competence factor to receptors in the spheroplast membrane of pneumococci.


Metabolism of some organophosphorus insecticides.


Glucose requirements of L cells infected with Chlamydia psittaci.


Bronchodilator activity of prostaglandin E2 when administered by aerosol to 3 species.


Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide.


Ego defense and aesthetic distortion: experimenter effects.


The stress of aircraft carrier landings. I. Corticosteroid responses in naval aviators.


The distribution of larvae of Brugia malayi and Brugia pahangi in the flight muscle fibres of Aedes aegypti and Mansonia uniformis.


The role of bone marrow in the immune response.


Serum LH and FSH during sexual maturation in the male rat: effect of castration and cryptorchidism.


Ego-resiliency, ego-control, and smoking cessation.


The Color Pyramid Test: a critical evaluation.


The national nutrition survey in the United States.


Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium.


Degeneration mydriasis and hyperemia of the iris after superior cervical ganglionectomy in the rabbit. Evidence for release of more than norepinephrine during degeneration of adrenergic terminals.


Polysaccharides of type XIX pneumococcus. I. Isolation of type specific polysaccharide.


The relation of reduced triphosphopyridine nucleotide cytochrome c reductase structure to its interaction with cofactors.


Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.


A thioredoxin induced by bacteriophage T4. II. Purification and characterization.


Rose Bengal as a reporter of the polarity and the acidity of the TPN binding site in 6-phosphogluconate dehydrogenase.


A reactive histidine residue at the active site of pig heart mitochondrial malate dehydrogenase.


Purification and properties of the nicotinamide-adenine dinucleotide phosphate-dependent isocitrate dehydrogenase from pig liver cytoplasm. The NADP-dependent isocitrate dehydrogenase from pig liver soluble fraction was purified over 500-fold with an overall yield of 25%. The purified enzyme, which is homogeneous by all the usual criteria, has a molecular weight of about 75000 and is composed of two identical subunits. This has been demonstrated by ultracentrifugation, fluorescence titration and peptide ;fingerprinting'. The maximal turnover number, extinction coefficients at 280nm and 260nm and amino acid analysis are described.


Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroides.


Evidence for two types of hydrogen atom in reduced nicotinamide-adenine dinucleotide phosphate arising from glucose 6-phosphate oxidation, based on the inhibitory action of certain steroids.


Differential effects of reduced nicotinamide-adenine dinucleotide phosphate on cytoplasmic-mitochondrial interactions.


Multiplicity of electron transport reactions in bacterial photosynthesis.


Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis.


Effect of methyl phenyldiazenecarboxylate (azoester) on lens membrane function.


Alteration of tyrosine aminotransferase turnover in rat liver following glucocorticoid administration.


Castration of horses and complications arising from this procedure.


Matrix-bound enzymes. II. Studies on a matrix-bound two-enzyme-system.


Male external genitalia of a girl caused by a virilizing adrenal tumour in the mother. Case report and steroid studies.


Antigastric acid secretory activities of N,N'-bis (1-naphthylmethyl)-1,4-cyclohexane bis (methylamine) dihydrochloride and structurally-related compounds in the rat.


A comparison of the cardiac activity of a new antiarrhythmic drug--pipazetate--with quinidine, procainamide, antazoline and diphenylhydantoin.


Influence of some antibiotics on stationary NAD and NADP concentrations in rat liver and kidney.


Effects of cerebroventricular perfusion of alpha and beta adrenergic blocking agents on carotid occulsion response.


Role of catecholamines in fatal hyperpyrexia induced by imipramine in MAOI treated rabbits.


Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex. 1. In the neuronally isolated cortex of the cat, local application of bemegride, picrotoxin, nikethamide, caffeine and strychnine facilitated the surface positive response of the isolated cortex and lowered the stimulus threshold for this response. Excepting nikethamide, they all produced convulsive discharge in the isolated cortex unrelated to the applied stimulus.2. Local application of glutamate to the cortex produced spreading depression, which was sometimes preceded by spontaneous positive bursting.3. In contrast to the "general depressants" which produce a relatively consistent pattern of effects on the electrical responses of isolated cortex, the "general stimulants", although they all have excitatory effects on isolated cortex, each produced a greatly different type of electrical response in the isolated cortex, suggesting that several different mechanisms of action are responsible for their effects.


Effects of drugs acting alone and in combination on the motor activity of intact mice. 1. When administered to intact white mice, the central depressants-diphenhydramine, promethazine, chlorpromazine, gammahydroxybutyrate, gammabutyrolactone, hyoscine, and pethidine-produced sedation in small doses, but excitement and convulsions in higher doses. When given to mice pretreated with subanaesthetic doses of phenobarbitone these drugs abolished the righting reflex both in convulsant doses (hyoscine excepted) and in non-convulsant doses. These effects are similar to the effects previously observed with local anaesthetics.2. Meprobamate, diazepam and chlorpromazine produced a loss of righting reflex both when given alone and following phenobarbitone. When given alone in higher doses, chlorpromazine induced convulsions.3. The central stimulants bemegride and picrotoxin antagonized the loss of righting reflex produced by phenobarbitone, but nikethamide, caffeine and strychnine did not alter the depressant effects of phenobarbitone.4. On the basis of these and previous studies with intact white mice a tentative classification of drugs having generalized depressant and stimulant effects on the central nervous system was proposed and discussed.


Adrenoceptors of the chick rectum.

Adrenoceptors of the chick rectum. 1. The aim of the investigation was to determine whether the adrenoceptors of the chick rectum preparation complied with Ahlquist's classification; phentolamine (0.1 mug/ml) and propranolol (0.05 mug/ml) were used as specific antagonists of alpha- and beta-adrenoceptors, respectively.2. Propranolol antagonized phenylephrine, isoprenaline and noradrenaline in the chick rectum preparation, although according to Ahlquist's classification phenylephrine stimulates alpha-adrenoceptors selectively.3. In the presence of propranolol, phenylephrine and noradrenaline produced small residual relaxations of the chick rectum preparation which were blocked by phentolamine. In the absence of propranolol, however, phentolamine did not antagonize relaxations to phenylephrine, isoprenaline or noradrenaline.4. The adrenoceptors of the guinea-pig colon preparation compiled with Ahlquist's classification in that they were like those generally present in intestine.


Effects of (plus or minus)-propranolol, (plus or minus)-,(plus)-, and (minus)-alprenolol on unanaesthetized dogs with ventricular arrhythmias resulting from coronary artery ligation. 1. The effects of (+/-)-propranolol, (+/-)-, (+)- and (-)-alprenolol were studied in unanaesthetized dogs with ventricular arrhythmias produced by ligation of the left coronary artery. The responses were compared with those of similar control dogs which were given only isotonic saline.2. The ventricular arrhythmias were abolished by cumulative doses of 3.5 mg/kg of (+/-)-alprenolol, 7.5 mg/kg of (-)-alprenolol and (+/-)-propranolol and by 15.5 mg/kg of (+)-alprenolol.3. At the time of maximum antiarrhythmic activity none of the drugs produced significant alterations in mean arterial pressure or atrial rate.4. Cumulative doses of 7.5 mg/kg and 15.5 mg/kg of the four drugs resulted in some instances of lip licking, emesis and/or head tremors while 31.5 mg/kg was invariably lethal.5. Since the beta-adrenoceptor blocking activity of (-)-alprenolol is 100 times greater than that of (+)-alprenolol, suppression of these ventricular arrhythmias was apparently unrelated to antagonism of sympathetic influences.6. Alprenolol and propranolol have myocardial depressant properties apart from their effects on beta-adrenoceptors which could account for the anti-arrhythmic activity observed.


Known mosquito hosts of western encephalitis virus in Saskatchewan.


A study of potential mosquito vectors of Dirofilaria immitis Leidy, on Okinawa, Ryukyu Islands.


Borderlines of medicine and ecology.

Borderlines of medicine and ecology.


MMPI profiles in exacerbation and remission of multiple sclerosis.


MMPI scales vs interviewer ratings of paranoia.


Manifest anxiety-defensiveness scale: first factor of the MMPI revisited.


Subtotal and total parotidectomy for chronic bacterial parotitis.


The effect of a ganglion-blocking agent (hexamethonium bromide) upon the secretory response to feeding in dogs with selective vagotomy of the parietal cell mass.


Seasonal decline of a mosquito population producing sample distortion.


Japanese encephalitis in Sarawak: studies on juvenile mosquito populations.


Japanese encephalitis in Sarawak: studies on adult mosquito populations.


Japanese encephalitis in Sarawak: studies on mosquito behaviour in a Land Dayak village.


Ricefield development and arbovirus epidemiology, Kano Plain, Kenya.


Japanese encephalitis in Sarawak: virus isolation and serology in a Land Dyak village.


Virus-inhibitory activity of 6-azauridine dependent on cell-free extracts containing uridine kinase. I. Inhibition of plaque-formation.


Virus-inhibitory activity of 6-azauridine dependent on cell-free extracts containing uridine kinase. II. Quantitative aspects, efficacy of pretreatment.


Production of high titres of interferon in chicken leukocyte cultures inoculated with human adenovirus type 12.


Replication of infectious bovine rhinotracheitis virus in calf kidney cells studied by immuno- and acridine orange-fluorescence.


Influence of anti-leucocyte serum on intraperitoneal vaccinia virus infection of rats.


The use of rivanol for removal of nonspecific inhibitors of arbovirus haemagglutination.


Arboviruses and central nervous system disorders in Egypt.


Immunodiffusion studies on a fluorocarbon-extracted antigen of lymphocytic choriomenigitis virus.


Comparative studies on buffalo pox, vaccinia and cow pox viruses in hamster kidney cell cultures.


Number of plaque forming units of Middelburg virus injected by Aedes aegypti during feeding.


Response of rabbit pancreas in vitro to adrenergic agonists and antagonists.


Quantitative and qualitative microbiological profiles of the Apollo 10 and 11 spacecraft. Microbiological profiles were determined for surfaces of the command module, lunar module (ascent and descent stages), instrument unit, Saturn S-4B stage, and the spacecraft lunar module adapter of the Apollo 10 and 11 spacecraft. Average levels of contamination of the command module were 2.1 x 10(4) and 2.7 x 10(4) microorganisms per ft(2) for Apollo 10 and 11, respectively. With the exception of the exterior surfaces of the ascent stage of the lunar module and the interior surfaces of the command module, average levels of microbial contamination on all components of the Apollo 11 were found to be lower than those observed on Apollo 10. For each Apollo mission, approximately 2,000 colonies were picked from a variety of media and identified. The results showed that approximately 95% of all isolates were those considered indigenous to humans; the remaining were associated with soil and dust in the environment. However, the ratio of these two general groups varied depending on the degrees of personnel density and environmental control associated with each module.


Development of four arboviruses in mice and application to rapid test procedures. Mice were inoculated with St. Louis encephalitis (SLE), Flanders (FLAN), California (CE), or Tensaw (TEN) viruses. At fixed intervals after inoculation, brains from these mice were collected and assayed for infective virus and complement-fixing, hemagglutinating, and precipitating antigens. Detectability of these antigens was correlated with the appearance of signs of illness in the mice. Infective virus appeared 64, 48, 48, and 40 hr before signs of illness and 90, 86, 64, and 56 hr before death in mice inoculated with SLE, FLAN, CE, and TEN viruses, respectively. Diagnostic antigens were also detected well before signs of illness appeared. These findings were applied to the isolation of viruses from field-collected specimens. It was shown that by harvesting tissues at appropriate intervals these viruses could be detected and identified more rapidly than by conventional techniques with mice.


The feedback inhibition of basal disk regeneration in Hydra has a continuously variable intensity.


Enzymes of glucose metabolism in normal mouse pancreatic islets. 1. Glucose-phosphorylating and glucose 6-phosphatase activities, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, NADP(+)-linked isocitrate dehydrogenase, ;malic' enzyme and pyruvate carboxylase were assayed in homogenates of normal mouse islets. 2. Two glucose-phosphorylating activities were detected; the major activity had K(m) 0.075mm for glucose and was inhibited by glucose 6-phosphate (non-competitive with glucose) and mannoheptulose (competitive with glucose). The other (minor) activity had a high K(m) for glucose (mean value 16mm) and was apparently not inhibited by glucose 6-phosphate. 3. Glucose 6-phosphatase activity was present in amounts comparable with the total glucose-phosphorylating activity, with K(m) 1mm for glucose 6-phosphate. Glucose was an inhibitor and the inhibition showed mixed kinetics. No inhibition of glucose 6-phosphate hydrolysis was observed with mannose, citrate or tolbutamide. The inhibition by glucose was not reversed by mannoheptulose. 4. 6-Phosphogluconate dehydrogenase had K(m) values of 2.5 and 21mum for NADP(+) and 6-phosphogluconate respectively. 5. Glucose 6-phosphate dehydrogenase had K(m) values of 4 and 22mum for NADP(+) and glucose 6-phosphate. The K(m) for glucose 6-phosphate was considerably below the intra-islet concentration of glucose 6-phosphate at physiological extracellular glucose concentrations. The enzyme had no apparent requirement for cations. Of a number of possible modifiers of glucose 6-phosphate dehydrogenase, only NADPH was inhibitory. The inhibition by NADPH was competitive with NADP(+) and apparently mixed with respect to glucose 6-phosphate. 6. NADP(+)-isocitrate dehydrogenase was present but the islet homogenate contained little, if any, ;malic' enzyme. The presence of pyruvate carboxylase was also demonstrated. 7. The results obtained are discussed with reference to glucose phosphorylation and glucose 6-phosphate oxidation in the intact mouse islet, and the possible nature of the beta-cell glucoreceptor mechanism.


Electrical potentials of the sigmoid colon and rectum in irritable bowel syndrome and ulcerative colitis. Using a simple and rapid method, electrical potential differences across rectal and colonic mucosa have been measured at routine sigmoidoscopy in patients with irritable bowel syndrome and ulcerative colitis. In patients with irritable bowel syndrome, all of whom had diarrhoea, the mucosa was charged negatively on the luminal side and potential differences were not significantly different from those of normal subjects. In acute exacerbations of ulcerative colitis, the potential difference was reversed, the luminal side being positive. This characteristic change was seen even in mild attacks. The potential difference was usually restored to normal within a few weeks of commencing treatment. In some cases, however, it was persistently abnormal for months and failed to show the normal response to stimulation by the mineralocorticoid, fludrocortisone. The way in which measurements of potential difference can be useful in diagnosis, prognosis, and as a guide to treatment is discussed.


Prevention of cyclopropane-adrenaline-evoked ventricular arrhythmias in the dog by selective beta-receptor antagonists.


Inhibition of gastrointestinal secretion.


Acidosis in low flow states.

Acidosis in low flow states.


Endotoxin shock and colibacillosis.

Endotoxin shock and colibacillosis.


Subacute pericarditis in a guinea pig caused by Diplococcus pneumoniae.


Relation of steroid structure to enzyme induction in hepatoma tissue culture cells.


Augmenters, reducers, and their reaction to cold pressor pain in waking and suggested hypnotic analgesia.


Motor performance under stress: a test of the inverted-U hypothesis.


Men of the sea: a description of a psychiatric population of merchant seamen using the M.M.P.I.


Graft-versus-host reactivity of mouse spleen cells separated on discontinuous albumin gradients.


Genetic and epidemiologic studies of oral characteristics in Hawaii's schoolchildren. I. Caries and periodontal disease.


Gastric mucosal ulceration after epinephrine. A study of etiologic mechanisms.


Role of the hypothalamus in the pathogenesis of cinchophen-induced gastric ulcers in dogs.


Influence of extracted teeth on DMF surface increments in clinical trials of caries preventives.


Public health and the law. "Physicians' assistants": the question of legal responsibility.


New pathway of ethanol metabolism in the liver.


The effect of a fluoride gel used for supervised toothbrushing 15 or 30 times per year.


Clinical anticaries effect of supervised toothbrushing with fluoride tablets for topical application.


220 MHz proton nuclear magnetic resonance study of the interaction between chicken M4 lactate dehydrogenase and reduced diphosphopyridine nucleotide. 220 MHz proton nuclear magnetic resonance investigations of reduced pyridine coenzymes and coenzyme fragments, both in the presence and absence of M(4) lactate dehydrogenase, show the following: (1) That the energy barrier between a folded and open conformation of the reduced pyridine coenzyme (in aqueous solutions) is insignificant because an unfavorable enthalpy change of 5 kcal is compensated for by a favorable entropy change of 19 entropy units. (2) The coenzyme, however, appears to maintain its intramolecularly folded conformation on contact with the enzyme. The binding of the coenzyme results in the immobilization of the adenine and pyridine moieties and there is no longer any gain in the conformational entropy as a result of unfolding as in aqueous solutions. (3) The purine moiety of the coenzyme facilitates the binding of the pyridine ring and indicates how high frequency nuclear magnetic resonance can be utilized to study binding of small molecules to enzymes.


Effect of pyridine nucleotide precursors on the permeability of toad bladder in the presence of vasopression, adenosine 3':5'-cyclic monophosphate, and theophylline. The increase and prolongation of water movement in the toad bladder in the presence of the pyridine nucleotide precursors adenine and nicotinamide (when stimulated with vasopressin, adenosine 3':5'-cyclic phosphate, or theophylline) suggests that pyridine nucleotides may be actively involved in membrane permeability.


Raven Progressive Matrices avoidable errors as a measure of psychopathological ideational influences upon reasoning ability.


Toward an operational definition of anhedonia.


The activity record: a measure of social isolation-involvement.


Effects of paraphrasing clinical interview items on structured responses.


Personality variables and sexual status in observer performance.


Physician's assistants.

Physician's assistants.


The effect of alkyl substitution in drugs. XXII. The antihistaminic and anticholinergic activity of a series of thio ether analogues of substituted diphenhydramines.


Pharmacology of a new antianginal drug: perhexiline. II. Heart rate and transmembrane potential of cardiac tissue.


Factors governing the kinetics and steady state of the mitochondrial nicotinamide nucleotide transhydrogenase system.


Studies on the immune responses of BALB-c mice during tumor induction by mineral oil.


Desaturation of saturated fatty acids by rat liver microsomes.


Use of anti-arrhythmic agents other than digitalis.


Pharmacological and dynamic factors in psychotropic drug therapy.


Propetties and composition of the nematocyst toxin of the sea anemone, Aiptasiapallida.


A comparative study of the tricarboxylic acid cycle enzymes in Fasciola hepatica and rat liver.


Comparative electrophoretic patterns of dehydrogenases in different species.


Valine activation of feeding in the sea anemone Boloceroides.


Current evaluation of fluorides in dentistry.


Some problems encountered in attempting to estimate catecholamine turnover using lbbelled tyrosine.


The absorption and excretion of carbenoxolone in man.


The effect of directly and indirectly acting sympathomimetic amines on bronchospasm in the guinea-pig during CO2 inhalation.


The effect of nialamide, pargyline and tranylcypromine on the removal of amphetamine by the perfused liver.


Selective determinations of amines and quaternary ammonium compounds as ion pairs with methyl orange by an automated method applicable to single dose analysis.


Determination of piribenzil in urine containing a metabolite and dextropropoxyphene by an ion pair extraction method.


An investigation of the distribution coefficients of some androgen esters using paper chromatography.


The effects of temperature on the critical micelle concentrations of alkyl alpha-picolinium bromiees.


Nuclear magnetic resonance spectroscopy of the trimethylsilyl ethers of some hydroxyphenylalkylamines.


Effects of oral thymoxamine on blood pressure and pupillary response in normal subjects.


Autacoids in sputum in cases of bronchial asthma and other respiratory diseases.


The stability of glyceryl trinitrate tablets.


An examination of some oil-in-water emulsions by electron microscopy.


A procedure for the estimation of oestradiol, prednisone and testosterone in propylene glycol.


Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat.


Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine.


Effects of 6-hydroxydopamine on the perfused rat mesentery preparation.


Antagonism by amantadine of prochlorpemazine-induced catalepsy.


Central dopamine and noradrenaline receptor activity of the amines formed from m-tyrosine, alpha-methyl-m-tyrosine and alpha-methyldopa.


Effects of chronic morphine administration on the catecholamine depletion induced by reserpine.


Alprenolol and propranolol in hyperthyroid tachycardia.


Drug receptor sites in the rabbit saphenous nerve. 1. The actions of acetylcholine, carbachol, methacholine, pilocarpine, nicotine, tetramethylammonium, 1,1-dimethyl-4-phenylpiperazinium, histamine, 5-hydroxytryptamine, angiotensin, bradykinin and potassium chloride were investigated on the sensory endings of the rabbit saphenous nerve.2. By means of specific antagonists the presence of separate receptor sites sensitive to acetylcholine, histamine, 5-hydroxytryptamine and bradykinin were demonstrated.3. The cholinoceptive receptors were shown to be predominantly nicotinic, but there was evidence of the existence of at least a small population of muscarinic receptors.4. Catecholamines of both alpha and beta types exhibited some stimulatory activity on administration. It is unlikely that this was due to either vasomotor effects or to any action involving the arrectores pilorum muscles.5. The alpha-receptor stimulants modified the response to acetylcholine in a biphasic way. There was a brief enhancement of effect followed by a more prolonged depression. beta-receptor stimulation only produced a prolonged enhancement of acetylcholine-evoked activity.6. The discharge generated by acetylcholine was augmented by anticholinesterases and blocked by ganglion blocking agents. None of these drugs in reasonable doses affected the response to stroking the fur. The results therefore support earlier evidence against a sensory cholinergic synaptic link.


A comparison of the effects of propranolol and practolol on the exercise tolerance in angina pectoris.


Myocardial effects of phentolamine.

Myocardial effects of phentolamine.


Cardiovascular effects of pentazocine in rabbits.


Cardiovascular actions of Wy 21901, a new hypotensive and anti-arrhythmic agent.


Autonomic blocking properties of Wy 21901.


Interaction of isoprenaline and beta-adrenoceptor blocking drugs on intestinal smooth muscle.


Relative affinities of some alpha-adrenoceptor blocking drugs in isolated human smooth muscle.


A comparison between the blocking actions of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) and its N-methyl quaternary analogue (AH 5954). 1. The neuromuscular blocking activities of AH 5183 (2-(4-phenylpiperidino) cyclohexanol) and its N-methyl quaternary analogue (AH 5954) were compared in rapidly stimulated nerve-skeletal muscle preparations of the rat, chicken and cat.2. The evidence indicated that in isolated preparations the neuromuscular block produced by both AH 5183 and AH 5954 was primarily pre-junctional in origin. That produced by AH 5954 was readily reversible either by washing the tissue or by reducing the stimulation frequency, whereas that produced by AH 5183 was difficult to reverse in these ways.3. Low doses of AH 5954 sensitized the rat hemidiaphragm preparation to the neuromuscular blocking action of choline. The neuromuscular block produced by choline was reversible by tetraethylammonium but not by neostigmine. This suggested that the blocking action of choline is at least partly pre-junctional in nature.4. In anaesthetized cats AH 5954 possessed a biphasic neuromuscular blocking action. The initial phase was rapid in onset, suggestive of a post-junctional action, whereas the second phase was prolonged and reversible by choline, suggestive of a prejunctional inhibitory action on the choline transport mechanism. AH 5183 produced no initial blocking action and was irreversible by choline.5. Both AH 5183 and AH 5954 possessed local anaesthetic and alpha-adrenoceptor blocking actions. These actions and the neuromuscular blocking action were affected to different degrees by quaternization, suggesting that the three main actions of the two drugs are independent.6. It was concluded that AH 5954 and AH 5183 act at different pre-junctional sites at the neuromuscular junction, AH 5954 acting extraneuronally by inhibiting choline transport and AH 5183 intraneuronally at the level of the synaptic vesicle membrane.


The immunodepressive activity of Escherichia coli L-asparaginase in some transplantation systems.


Evaluation of a new alpha-blocking vasodilator agent (thymoxamine) in peripheral vascular disease.


Contributions of coronary perfusion pressure, metabolic acidosis and adrenergic factors to the reduction of myocardial contractility during hemorrhagic shock in the cat.


Cardiovascular effects of sustained norepinephrine infusions in dogs. IV. Previous treatment with adrenergic blocking agents.


Morphogenesis in hydra. II. Peduncle and basal disc formation at the distal end of regnerating hydra after exposure to low temperatures.


Gene action and its control in micro-organisms.


Selfish and spiteful behaviour in an evolutionary model.


Control of gene action in Aspergillus nidulans.


Organ-specific gene masking in mammalian chromosomes.


Hormonal control of protein synthesis.

Hormonal control of protein synthesis.


Nuclear transplantation and the control of gene activity in animal development.


The use of cell fusion in the analysis of gene action.


The genetic analysis of puffing in polytene chromosomes of Drosophila.


Gene action in development.

Gene action in development.


Metabolic fate of 3,4,5- and 2,3,5-trimethylphenyl methylcarbamates, the major constituents in Landrin insecticide.


Pharmacology of the central nervous system.


Psychological assessment methods.

Psychological assessment methods.


Conformation of pyridine dinucleotides in solution.


Relation between a dimension of internal-external control and the MMPI with an alcoholic population.


The morphology of immune reactions in normal, thymectomized and reconstituted mice. 3. Response to bacterial antigens: salmonellar flagellar antigen and pneumococcal plysaccharide.


Anxiety, structure, or social desirability?


Effect of accurate forecasts on length of hospital stay of psychiatric patients.


New model for transmitter release at the presynaptic membrane.


Irreversible antagonism at the adrenergic alpha-receptor: the role of calcium.


Inhibition of casein hydrolysate induction and insulin induction of hepatic tyrosine transaminase in the rat.


Socio-odontologic investigation of school children with high and low caries frequency. I. Socio-economic background.


Some haemodynamic effects of LB 46 (Visken).


A case of self-poisoning with Carbrital.


Accelerated decay of glucose 6-phosphate dehydrogenase activity in chronic granulomatous disease.


Deficiency of a glucocorticoid inducible isoenzyme of liver tyrosine aminotransferase in the obese C57BL-6J-ob mutant mouse.


D-glyceraldehyde-3-phosphate dehydrogenase in photosynthetic cells. I. The reversible light-induced activation in vivo of NADP-dependent enzyme and its relationship to NAD-dependent activities.


Phosphopyruvate carboxylase from entamoeba histolytica.


Studies on yeast sulfite reductase. 3. Further characterization.


Angiitis in drug abusers.

Angiitis in drug abusers.


Allogeneic inhibition in thymectomized animals lacking homograft reactivity.


Effect of acute hemorrhage on arterial and venous resistance.


Tween 20 shock in dogs and related fibrinogen changes.


The Medical Commission on Accident Prevention.


Effect of oxprenolol on adrenaline-evoked ventricular arrhythmias in dogs anaesthetized with halothane in oxygen.


Beta blockade in flutter.

Beta blockade in flutter.


The current status of pancreatic transplantation.


Automatic apparatus for the spectrophotometric assay of certain enzymes.


The use of homografts in burn therapy.

The use of homografts in burn therapy.


The thymus, thymosin and anti-thymosin.

The thymus, thymosin and anti-thymosin.


Physicians' assistants: an opinion.

Physicians' assistants: an opinion.


Treatment and pretreatment of graft-versus-host reaction by antilymphocyte serum.


A simple purification method of D-amino acid oxidase.


Different effect of aflatoxin on the induction of tryptophan oxygenase and of microsomal drug-hydroxylase system.


A current nursing issue. Is the R.N. losing her identity?


Subcellular particles in tumors. 3. Peroxisomal enzymes in hepatoma HC and Morris hepatomas 7794A, 7794B, 5123A and 7316A.


The effects of some tetracyclnnes on synchronously growing cultures of Eschericihia coli B-r.


Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides.


Arteritis.

Arteritis.


The excitatory and inhibitory innervation of the stomachs of the domestic fowl.


N-(perhydroazepinoalkynyl)- and N-(perhydroazocinoalkynyl) succinimides as oxotremorine antagonists.


New man in town: the P.A.

New man in town: the P.A.


The physician's assistants. Why they're needed.


The physician's assistants. An inside look at three programs.


Cellular effects of alcohol. A review.

Cellular effects of alcohol. A review.


The physician's assistants. A visit to Bowman Gray.


The physician's assistants. How nurses view their P.A.s.


The physician's assistants. The road ahead--as nurses see it.


The physician's assistants. Officially speaking...


Undescended testes: surgery and its results.


Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis. 1. NADP-malate dehydrogenase and ;malic' enzyme in maize leaf extracts were separated from NAD-malate dehydrogenase and their properties were examined. 2. The NADP-malate dehydrogenase was nicotinamide nucleotide-specific but otherwise catalysed a reaction comparable with that with the NAD-specific enzyme. By contrast with the latter enzyme, a thiol was absolutely essential for maintaining the activity of the NADP-malate dehydrogenase, and the initial velocity in the direction of malate formation, relative to the reverse direction, was faster. 3. For the ;malic' enzyme reaction the K(m) for malate was dependent on pH and the pH optimum varied with the malate concentration. At their respective optimum concentrations the maximum velocity for this enzyme was higher with Mg(2+) than with Mn(2+). 4. The NADP-malate dehydrogenase in green leaves was rapidly inactivated in the dark and was reactivated when plants were illuminated. Reactivation of the enzyme extracted from darkened leaves was achieved simply by adding a thiol compound. 5. The activity of both enzymes was low in etiolated leaves of maize plants grown in the dark but increased 10-20-fold, together with chlorophyll, when leaves were illuminated. 6. The activity of these enzymes in different species with the C(4)-dicarboxylic acid pathway was compared and their possible role in photosynthesis was considered.


Discriminating violence emanating from over-controlled versus under-ontrolled aggressivity.


Oxidation-reduction reactions involving ascorbic acid and the hexosemonophosphate shunt in corneal epithelium.


The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. 1. Adipose tissues from rats fed a balanced diet were incubated in the presence of glucose (20mm) with the following additions: insulin, anti-insulin serum, insulin+acetate, insulin+pyruvate, insulin+lactate, insulin+phenazine methosulphate, insulin+oleate+albumin, insulin+adrenaline+albumin, insulin+6-N-2'-O-dibutyryl 3':5'-cyclic AMP+albumin. 2. Measurements were made of the whole tissue concentrations of adenine nucleotides, hexose phosphates, triose phosphates, glycerol 1-phosphate, 3 phosphoglycerate, 6-phosphogluconate, long-chain fatty acyl-CoA, acid-soluble CoA, citrate, isocitrate, malate and 2-oxoglutarate, and of the release into the incubation medium of lactate, pyruvate and glycerol after 1h of incubation. 3. Fluxes of [(14)C]glucose carbon through the major pathways of glucose metabolism were calculated from the yields of (14)C in various products after 2h of incubation. Fluxes of [(14)C]acetate, [(14)C]pyruvate or [(14)C]lactate carbon in the presence of glucose were also determined. 4. Measurements were also made of the whole-tissue concentrations of metabolites in tissues taken directly from Nembutal-anaesthetized rats. 5. Whole tissue mass-action ratios for phosphofructokinase, phosphoglucose isomerase and the combined (aldolasextriose phosphate isomerase) reaction were similar in vivo and in vitro. The reactants of phosphofructokinase appeared to be far from mass-action equilibrium. In vitro, the reactants of hexokinase also appeared to be far from mass-action equilibrium. 6. Correlation of observed changes in glycolytic flux with changes in fructose 6-phosphate concentration suggested that phosphofructokinase may show regulatory behaviour. The enzyme appeared to be activated in the presence of oleate or adrenaline and to be inhibited in the presence of lactate or pyruvate. 7. Evidence is presented that the reactants of lactate dehydrogenase and glycerol 1-phosphate dehydrogenase may be near to mass-action equilibrium in the cytoplasm. 8. No satisfactory correlations could be drawn between the whole-tissue concentrations of long-chain fatty acyl-CoA, citrate and glycerol 1-phosphate and the observed rates of triglyceride and fatty acid synthesis. Under the conditions employed, the concentration of glycerol 1-phosphate appeared to depend mainly on the cytoplasmic [NAD(+)]/[NADH] ratios. 9. Calculated hexose monophosphate pathway flux rates roughly correlated with fatty acid synthesis rates and with whole tissue [6-phosphogluconate]/[glucose 6-phosphate] ratios. The relative rates of production of NADPH for fatty acid synthesis by the hexose monophosphate pathway and by the ;malic enzyme' are discussed. It is suggested that all NADH produced in the cytoplasm may be used in that compartment for reductive synthesis of fatty acids, lactate or glycerol 1-phosphate.


The transformation of both recipient strands of pneumococcal DNA.


Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.


Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.


Effect of Chrysaora quinquecirrha (sea nettle) toxin on rat nerve and muscle.


Forecasting median and mode dates of prevalence of Japanese encephalitis patients by electronic computer (epidemiological studies on Japanese encephalitis, 31).


An unusual case of chlorpromazine agranulocytosis.


Lithium responders: an evaluation of psychological test characteristics.


Response of mesenteric blood flow to glucagon. Influence of pharmacological stimulation and blockade of adrenergic receptors.


Effect of thioproperazine on 5-HIAA content in urine and cerebrospinal fluid of chronic schizophrenic patients.


Altered fatty acid distribution in mutants of Neurospora crassa. Morphological mutants of Neurospora with decreased levels of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and reduced nicotinamide ad enine dinucleotide (NADH) contained only 20% as much of a polyunsaturated fatty acid (linolenic acid) as the wild type in both the phospholipid and neutral lipid fractions. There was an excellent correlation between linolenic acid levels and morphological appearance as a function of total NADPH content, but no correlation with NADH content. The linolenic acid deficiency was balanced by a relative increase in the amounts of the less unsaturated fatty acids (oleic and linoleic acids), but the level of three other fatty acids did not appear to be changed. This accumulation of these two precursors suggests that the NADPH deficiency preferentially affected the final desaturation step, i.e., the conversion of linoleic to linolenic acid. The NADPH needed for this reaction in vivo was probably generated by the pentose phosphate shunt, since mutations affecting the shunt lead to the decreased levels of linolenic acid. It is not clear whether the changes in fatty acid distribution affect the morphogenesis of Neurospora, or if these changes are just part of the NADPH-deficiency syndrome.


Effect of therapist-patient personality variables on therapeutic outcome.


Asthma of unknown origin as a psychological group.


Item analyses of the MMPI Mf scale using homosexual and heterosexual males.


Host preferences of mosquitoes.

Host preferences of mosquitoes.


Arboviruses known to occur in California and their relationship to different vectors and vertebrate hosts.


Leukemia virus activation in chronic allogeneic disease. Young adult (BALB/c x A/J)F(1) hybrid mice have no detectable leukemia viruses. When inoculated with parental BALB/c spleen lymphoid cells, also free of detectable virus, leukemia viruses rapidly become activated in the injected host. Because of similarities between such graft-induced allogeneic disease and spontaneous autoimmunity, it is proposed that autoimmune reactions may activate latent viruses.


Arbovirus research in the Sacramento Valley.


The Declaration of Oslo.

The Declaration of Oslo.


Staged orchiopexy.

Staged orchiopexy.


A study on the neotetrazolium reductase system in the kidney cells of chick embryo by microspectrophotometry. II. Determination of the activity of the NADP-dependent dehydrogenase system.


Kinetic studies on the reaction mechanism of p-hydroxybenzoate hydroxylase.


Observations on three species of jellyfishes from Chesapeake Bay with special reference to their toxins. I. Chrysaora (Dactylometra) quinquecirrha.


Involvement of photosystem two in non-oxygen evolving non-cyclic, and in cyclic electron flow processes in chloroplasts.


The relationship of caries prevalence data and diagnosed treatment needs in a child population.


A probable intermediate in the enzymic reduction of 3-hydroxy-3-methylglutaryl coenzyme A.


The view box.

The view box.


Acoustic neuroma.

Acoustic neuroma.


Giant fibroma (fibromatosis) of mesentery.


Pathology of ocular trauma.

Pathology of ocular trauma.


Supreme Court decision in hepatitis case.


Medical care of the elderly patient.

Medical care of the elderly patient.


The controversy over vitmin E.

The controversy over vitmin E.


Pilot project in medical review successfully completed.


Microspectrophotometric study of oxidative enzymes in irradiated epidermis.


The pharmacology of isolated sheep umbilical cord blood vessels.


Nutritional circulation in the heart. 3. Effect of isoproterenol and beta adrenergic blockade on myocardial hemodynamics and rubicium-86 extraction in the isolated supported heart preparation.


The renal tubular transport and metabolism of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the chicken.


Clinical investigation of a new broncholyticum--decloxizine--as compared with franol and placebo treatment.


Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Mouse lymphoma cells in culture which are killed by adrenal steroids contain specific cortisol receptors that may be involved in the initial events of hormone action. The similarity of these receptors to those in hepatoma tissue culture cells, where adrenal steroids induce tyrosine aminotransferase, suggests that certain aspects of steroid action are similar in the two systems. In three steroid-resistant lymphoma cell populations specific binding was less than in the parent lines, suggesting that conversion to steroid resistance may be associated with changes in specific steroid binding.


Supraoptic neurosecretory cells: adrenergic and cholinergic sensitivity. Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-beta-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine are directly involved in controlling the release of antidiuretic hormone.


Tolerances to thermal extremes in aerospace activities.


Atmospheric oxygen: effect on resistance of mice to pneumococcal pneumonia.


Betting preferences and personality characteristics of Navy divers.


Heparin efficacy in burns. II. Human thermal burn treatment with large doses of topical and parenteral heparin.


Impaired abstracting ability in chronic alcoholics.


Carnarvon studies. IV. Prevalence of ntal caries in 472 Caucasian schoolchildren examined in Carnarvon, Western Australia (August 1963).


The use of implants as an aid to prosthodontics.


The relationship between dental caries and salivary properties at adolescence.


An ATP-dependent deoxyribonuclease from diplococcus pneumoniae. I. Partial purification and some biochemical properties.


Studies on the structure of tyrosine aminotransferase.


An ATP-dependent deoxyribonuclease from Diplococcus pneumoniae. II. Evidence for its involvement in bacterial recombination.


Rumen acidosis in goats.

Rumen acidosis in goats.


Dissociation of splenomegaly from graft-versus-host disease by host x-irradiation.


The influence of pronethalol on rabbit myocardial lipid metabolism.


Studies on immune lymphocyte transfer reactions in murine homologous cell chimeras.


Deficient cell-mediated immunity in adult NZB mice.


Alprenolol in the treatment of arrhythmias in acute coronary patients.


Polyarteritis nodosa: the natural history of a spontaneously occurring model in outbred mice.


Virus isolations from mosquitoes collected in North Arcot district, Madras state, and Chittoor district, Andhra Pradesh between November 1955 and October 1957.


Punishment, arousal, and avoidance learning in sociopaths.


Vicarious conditioning and sociopathy.

Vicarious conditioning and sociopathy.


Differentiation similarity of patient and therapist and the outcome of psychotherapy.


The academic health center and health care delivery. Preparing personnel to meet the demand.


Self-disclosure with recidivists: optimum interviewer-interviewee matching.


Personality and attitude change after two alcoholism treatment programs. Comparative contributions of lysergide and Human Relations Training.


Paramedical personnel in the distribution of health care.


Psychopathology and seasonal preferences; an aspect of temporal experience.


Where do nurses fit in the delivery of health care?


Renal transplantation. Certain immunological considerations.


Human renal transplantation. Progress in organ preservation in vitro.


Effects of ACTH and related polypeptides on spinal cord.


Results of the use of a new beta-adrenergic blocker (LB 46) in angina pectoris.


Electron microscopic observations on the participation of blood leukocytes in the production of some renal glomerular lesions.


Beta-blockers in hypertension.

Beta-blockers in hypertension.


Development and validation of a psychological screening inventory.


Energy cost of gluconeogenesis in rat liver.


Role of mitochondria in metabolism of pyruvate and lactate by rat adipose tissue.


Pharmacological principles in the management of accidential poisoning.


Emergency management of poisoning.

Emergency management of poisoning.


Re-evaluation of the use of activated charcoal in the treatment of acute poisoning.


Basic toxicology.

Basic toxicology.


Poisoning with psychoactive drugs.

Poisoning with psychoactive drugs.


Therapy of sedative overdosage.

Therapy of sedative overdosage.


Influence of chronic administration of nicotine on the turnover and metabolism of noradrenaline in the rat brain.


The medical-services associate: a new health career for the improvement of health-care delivery.


Training of allied health professionals and physicians' assistants.


Community participation for equity and excellence in health care. General discussion 3.


The antidepressant properties of A-25794: a pilot study.


Kinetic analysis of he glucosephosphate isomerase-glucose-6-phosphate dehydrogenase system from yeast in vitro.


Incremental rates of dental caries after repeated topical sodium fluoride applications in children with lifelong consumption of fluoridated water.


The effect on dental caries of topically applied acidulated phosphate-fluoride: results after three years.


Pulmonary abnormalities in the necrotizing vasculitides and their rapid response to steroids.


Eubenangee (EUB) strain. In 1074.

Eubenangee (EUB) strain. In 1074.


Trubanaman (TRU) strain. MRM 3630.

Trubanaman (TRU) strain. MRM 3630.


Main Drain (MD) strain. BFS 5015.

Main Drain (MD) strain. BFS 5015.


Lokern (LOK) strain. FMS 4332.

Lokern (LOK) strain. FMS 4332.


Tanga (TAN) strain. MP 1329.

Tanga (TAN) strain. MP 1329.


Mount Elgon Bat (MEB) strain. BP 846.

Mount Elgon Bat (MEB) strain. BP 846.


Okola (OKO) strain. YM 50-64.

Okola (OKO) strain. YM 50-64.


Dugbe (DUG) strain. AR 1792.

Dugbe (DUG) strain. AR 1792.


Shuni (SHU) strain. AN 10107.

Shuni (SHU) strain. AN 10107.


Aino (AINO) strain. JaNAr 28.

Aino (AINO) strain. JaNAr 28.


Tamiami (TAM) strain. W-10777.

Tamiami (TAM) strain. W-10777.


Arbovirus infections in Sarawk: virus isolations from mosquitoes.


Kallikrein as a pathogenic agent in Plasmodium knowlesi infection in Macaca mulatta.


Hypertension. II.

Hypertension. II.


Infectious complications in bone marrow transplant patients. In 11 patients receiving transplants of allogeneic bone marrow, the graft was successful in six. Nine patients developed infections, and six died-five of septicaemia and one of Pneumocystis carinii pneumonia. Fifty individual infections occurred. Predisposing factors included severe underlying diseases, long-term exposure to resistant hospital organisms, heavy immunosuppressive therapy, and graft-versus-host disease. Gram-negative bacilli and Candida albicans were the most common causative organisms. In every instance of septicaemia identical organisms were isolated from blood cultures and simultaneously obtained stool cultures. Infection with exogenous organisms often occurred in patients occupying conventional isolation rooms. Isolation of one patient for 45 days in a laminar air flow room prevented infection with exogenous organisms.


Synthesis of corticosteroids by the interrenal gland of selachian elasmobranch fish.


Effects of disintegration of incorporated 3H and 32P on the physical and biological properties of DNA.


Transoceanic flight of mosquitoes on the Northwest Pacific.


Hydroxyproline in the allantoic fluid of the mare.


Increased resistance to penicillin of pneumococci isolated from man.


Can adrenergic blockers be leukemogenic?


Increased resistance in the pneumococcus.


The junior physician (assistant physician) and the physician's assistant.


The pa: "Junior physician" or "supernurse"?


International trauma symposium: the challenge.


Sterol metabolism. XVI. Cholesterol 20-alpha-hydroperoxide as an intermediate in pregnenolone biosynthesis from cholesterol.


Isolation of a peptide containing fucose, mannose and hexosamine from Metridium dianthus collagen.


Isolation and properties of Renilla reniformis luciferase, a low molecular weight energy conversion enzyme.


In vitro dechlorination of a 4,6-dichloro-delta-4,6-keto steroid.


The use of sulthiame with disturbed mentally subnormal patients.


Biochemical and histochemical observations on isocitrate dehydrogenase activity in early wound healing.


Calcium evoked release of 5-hydroxytryptamine from the brain of the unanesthetized cat.


Release of kinins from site of wheal-and-flare allergic skin reactions.


Ego strength, skin conductance, sleep deprivation, and performance.


Cardiostimulatory effects of oxyfedrine, DMPP and sympathomimetics in relation to their 3H-noradrenaline-releasing properties.


Biologically active benzo (b)thiophene derivatives.


Hemodynamic responses to tilt and beta-adrenergic blockade in young patients with borderline hypertension.


Endogenous broncho-active substances and their antagonism.


The effect of adrenalectomy on the production of homocytotropic antibody in rats.


Psychotic-appearing MMPI profiles among alcoholics.


Declination rates on the MMPI validity and clinical scales.


Validation of the Eysenck Personality Inventory by the MMPI and internal-external control scale.


Verbal conditioning as related to awareness, paranoia, and suspiciousness.


The MMPI "conversion V" among 50,000 medical patients: a study of incidence, criteria, and profile elevation.


Factors influencing administrative disposition of psychiatric patients.


MMPI "cookbooks": are rule relaxation and system combination procedures an answer to low classification rates?


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-1971.


Psychologic and social precursors of coronary disease (first of two parts).


Use of amphetamines.

Use of amphetamines.


Abortive effects and comparative metabolism of chlorcyclizine in various mammalian species.


Functional assessment of canine lung transplants by radioisotope lung scanning procedures.


Caries incidence in human primary teeth during the period of the mixed dentition.


The glyceraldehyde 3-phosphate dehydrogenase of Azotobacter beijerinckii and its possible significance in poly-beta-hydroxybutyrate biosynthesis.


An enzymically active P-420-type cytochrome involved in the mixed-function dimethylamine oxidase system of Pseudomonas aminovorans.


Facilitation of the flexor reflex in the cat by intrathecal injection of catecholamines. 1. Effects of some alpha- and beta-adrenoceptor stimulants and antagonists were investigated on flexor reflex (FR) in chloralosed cats.2. Noradrenaline (NA) produced facilitation of FR which was dose-dependent and reproducible and was blocked by alpha-adrenoceptor blocking agents.3. Strychnine also produced facilitation of FR but the response was unaffected by alpha-adrenoceptor blocking agents.4. Metaraminol and alpha-methyl-noradrenaline had little effect on FR but blocked the NA response.5. beta-adrenoceptor stimulants and antagonists had neither any effect on FR nor modified the NA response.6. Vasopressin and histamine also failed to modify FR.7. Possibility of alpha-adrenoceptors in the neurones integrating FR is suggested.


The kinetic properties of spinach leaf glyoxylic acid reductase.


Multiple regulatory processes in nicotinamide adenine dinucleotide-specific glutamic dehydrogenases. Catabolite repression; nicotinamide adenine dinucleotide phosphate, reduced nicotinamide adenine dinucleotide phosphate, and phosphoenolpyruvate as activators; allosteric inhibition by substrates.


Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans.


Wood WA: L-ribulose 5-phosphate 4-epimerase of Aerobacter aerogenes. Evidence for nicotinamide adenine dinucleotide-independent 4-epimerization by the crystalline enzyme.


Regulation of adenosine diphosphate glucose synthase from Escherichia coli. Interactions of adenylate energy charge and modifier concentrations.


Hexose monophosphate pathway in synapses.


The marshfield clinic physician-assistant concept. Critical evaluation of advantages, disadvantages and prospects.


New allied health professionals: implications of the Colorado child health associate law.


Licensure of responsible delegation?

Licensure of responsible delegation?


Use of propranolol in thyrotoxicosis.

Use of propranolol in thyrotoxicosis.


Studies on the transmission of hypostome inhibition in hydra.


Experimental studies on axial polarity in hydra.


Renal transplantation in the early 1970's.


Post-anesthetic tissue necrosis in experimental pedicle skin flaps.


Oxygen effect in gamma-irradiated DNA.

Oxygen effect in gamma-irradiated DNA.


Isolation of a benz(a)pyrene-thymine photoadduct from DNA hydrolized after irradiation at 365 nm in the presence of benz(a)pyrene.


On the nature of hemoglobin-haptoglobin interaction.


Experiments regarding the problem of differentiation in multicellular systems.


Metabolism of human erythrocyte glucose 6-phosphate dehydrogenase. II. Changes of quaternary structure of the enzyme during the metabolite induced inactivation and reactivation.


Formaldehyde induced changes of heat-denatured DNA.


Transcription of 4S RNA in Limnaea (mollusc) embryos.


Interactions of adrenergic blocking drugs with the in vivo release of thyroid hormone induced by thyrotrophin and the long-acting thyroid stimulator.


Metabolism of dehydroepiandrosterone by rat testicular homogenates; kinetic study at different temperatures; direct effect of 17 beta-oestradiol.


The experimental basis for the choice of an anti-arrhythmic drug.


Treatment of gram-negative shock.

Treatment of gram-negative shock.


The influence of psychotropic drugs on the level and metabolism of noradrenaline in brain and behavior of rats.


Nitrite and hydroxylamine reduction in higher plants. Fractionation, electron donor and substrate specificity of leaf enzymes, principally from vegetable marrow (Cucurbita pepo L.). Nitrite reductase was purified between 760- and 1300-fold from vegetable marrow (Cucurbita pepo L.) and residual hydroxylamine reductase activity was low or negligible by comparison. With ferredoxin as electron donor, nitrite loss and ammonia formation at pH7.5 were stoicheiometrically equivalent. Crude nitrite reductase preparations showed negligible activity with NADPH as electron donor maintained in the reduced state by glucose 6-phosphate, whereas by comparison, activity was high when either ferredoxin or benzyl viologen were also present and reduced by the NADPH-glucose 6-phosphate system, whereas FMNH(2) produced variable and relatively low activity under the same conditions. At pH values below 7, non-enzymic reactions occurred between reduced benzyl viologen and nitrite, and intermediate reduction products were inferred to be produced instead of ammonia. Activity with ferredoxin (0.1mm), reduced by chloroplast grana in the light, was 25 times that produced with ferredoxin (40mum) reduced with NADPH and glucose 6-phosphate. For an approximate molecular weight 61000-63000 derived by chromatography on Sephadex G-100 and G-200, and a specific activity of 46mumol of nitrite reduced/min per mg of protein with light and chloroplast grana, a minimum turnover number of 3x10(3)mol of nitrite reduced/min per mol of enzyme was found. Two hydroxylamine reductases were separated on Sephadex gels. One (HR1) was initially associated with nitrite reductase during gel filtration but disappeared during later fractionation. This HR1 fraction showed nearly comparable activity with reduced benzyl viologen, ferredoxin or FMNH(2). The other (HR2), of molecular weight approx. 35000, reacted with reduced benzyl viologen but showed negligible activity with ferredoxin or NADPH. Activity with FMNH(2) was associated with an irregular trailing boundary during gel filtration, with much diminished activity in the HR2 region. Activity with NADPH was about 30% of that with FMNH(2), reduced benzyl viologen or ferredoxin and was considered to reside in fraction HR1. Hydroxylamine yielded ammonia under all assay conditions. No activity with hyponitrite or sulphite was observed with reduced benzyl viologen as electron donor in either the nitrite reductase or the hydroxylamine reductase systems, but pyruvic oxime produced about 4% of the activity of hydroxylamine.


The stereochemistry of hydrogen transfer from reduced nicotinamide-adenine dinucleotide phosphate in the reduction of ethylenic linkages during cholesterol biosynthesis. It is shown that during the saturation of steroid carbon-carbon double bonds at Delta(24,25) and Delta(14,15) the ;hydride ion' originates from the 4B side of the NADPH.


The physician assistant. A challenge toward bridging the gap.


The Diamond Jubilee Convention of the National Medical Association.


Vasomotor rhinitis.

Vasomotor rhinitis.


Observations on a haemorrhagic bowel syndrome involving pigs on three associated premises.


Interference of membrane pump blocking and alpha-receptor blocking drugs with noradrenaline release from isolated tissues.


Metabolic effects of prolonged sympathetic nerve stimulation in canine subcutaneous adipose tissue.


Omega- and (omega - 1)-oxidation of fatty acids by rat liver microsomes.


On the fluorescence of NAD(P)H in whole-cell preparations of tumours and normal tissues.


Comparative electron-nuclear double resonance study of two flavoproteins.


Antiarrhythmic, anticonvulsant and local anaesthetic activity of cyclizine, chlorcyclizine and homchlorcyclizine.


Superinduction of tyrosine aminotransferase by actinomycin D in rat hepatoma (HTC) cells.


Effects of duration of convulsions on energy reserves of the brain.


Metabolism of glucose and reduction of retinaldehyde in retinal photoreceptors.


Relationship of phenylalanine to seizure threshold during maturation.


Effects of dichloroisopropylarterenol on respiration, nucleotide (the difference between) P and phospholipids of slices of cerebral cortex.


Brain energetics and neurosurgery. A review of recent studies done at Duke University.


Behavioral reactions of the sea anemone, Anthopleura xanthogrammica, to ultraviolet and visible radiations.


Sleep stage and personality characteristics of "natural" long and short sleepers. A group of college freshmen that typically slept 5(1/2) hours or less per night and a group that typically slept 9(1/2) hours or more did not differ significantly on a battery of personality, scholastic, and medical measures. Compared with control subjects not selected on a sleep length criterion, electroencephalograph recordings of the short sleepers contained reduced amounts of stage 2 and rapid eye movement sleep.


Nucleic acid synthesis and nucleotide pools in purine-deficient Escherichia coli. 1. The synthesis of nucleic acids and the content of purine nucleotides have been studied in selected purine-requiring strains of Escherichia coli including a purB(-) strain and a purB(-)guaA(-) strain. 2. When the exogenous purines can be converted into GTP but not into ATP, RNA is synthesized at the expense of intracellular ATP, ADP and AMP. 3. Net synthesis of RNA as measured by the incorporation of uracil can be correlated with the availability of GTP except when ATP falls to a very low concentration. 4. Nicotinamide nucleotides are not an important reservoir of adenine nucleotides for RNA synthesis.


Effects of oxprenolol on cardiac contractile force, heart rate and coronary circulation.


The effect of oxprenolol on airwy resistance.


Metabolic studies on oxprenolol in animals and man by means of radio-tracer techniques and GLC-analysis.


Comparison of immediate haemodynamic effects of three beta-adrenergic blocking agents.


Haemodynamic effects of intravenous oxoprenolol.


Comparison of tests of adrenergic beta-receptor blockade in man and their application to a comparison of the beta-blocking potency of propranolol and oxprenolol.


Pharmacological aspects of oxprenolol.

Pharmacological aspects of oxprenolol.


Effect upon myocardial blood-flow in man of beta-blocking agents, isosorbide dinitrate, dipyridamole and their combination.


Haemodynamic effects of oxprenolol in hypertensive patients.


Circulatory and electrocardiographic effects of oxprenolol in angina pectoris.


The action of intravenous oxprenolol, practolol, propranolol and sotalol on acute exercise tolerance in angina pectoris: the effect on heart rate and the electrocardiogram.


Long-term clinical results of oxprenolol in the treatment of cardiac arrhythmias, angina pectoris and hypertrophic subaortic stenosis.


The treatment of functional heart disorders with beta-adrenergic blocking agents.


The effect of beta-adrenergic blocking drugs on myocardial function: an explanation at the subcellular level.


Roentgenographic comparison of state of teeth in dental students in 1948 and 1968.


Polyarteritis nodosa in two siblings.

Polyarteritis nodosa in two siblings.


Personality factors in marihuana use: a preliminary report.


Amino-acid oxidase action on D- and L-alpha, gamma-diaminobutyric acids.


Separation of NAD+ and NADH and NADP+ aned NADPH by anion exchange on DEAE-cellulose paper.


Glutathione: a source of interference in pyridine nucleotide determinations by a cycling procedure.


Catecholamines in hypertension.

Catecholamines in hypertension.


Treadmill investigations into the action of beta receptor antagonists on blood pressure and pulse rate.


Acute circulatory effects of a beta adrenergic blocking agent (LB 46) in patients with sympathetic overstimulation.


The impact of diurnal rhythm on drug dosing and drug evaluation.


Beta-adrenergic blocking therapy in hypertension: selection of patients.


Response to dextran in posthemorrhagic shock after combined adrenergic receptor blockade.


The HL-A system. Genetic and biological implications.


Rapid diagnosis of Aujeszky's disease by the fluorescent antibody technique.


Hyperimmunizing effect of live rubella virus inoculated into the rabbit's anterior eye chamber.


Haemodynamic changes in patients with coronary heart disease after beta-adrenergic blockade with propranolol.


Exaggerated delayed hypersensitivity to mosquito venom in association with lymphoproliferative disorders.


Distribution of tritiated-1 delta 9tetrahydrocannabinol in rat tissues after inhalation.


Stimulation of two adaptive rat liver enzymes by quinolinic acid as a function of time.


Some clinical aspects of hypo-orchidism (small testes) in the ram.


The 503nm pigment of Escherichia coli.

The 503nm pigment of Escherichia coli. The yield of cell protein was one-third less for streptomycin-dependent Escherichia coli B than for the wild-type parent strain when both were grown aerobically on a medium with limiting glucose, but anaerobically the yield of protein was similar for both strains. The transient pigment absorbing at 503nm that is known to be present in E. coli and other organisms was not detectable in streptomycin-dependent mutants nor in a non-dependent (energy-deficient) revertant. When wild-type E. coli B was grown on limiting glucose-salts medium containing 2,4 dinitrophenol, the yield of cell protein was decreased and formation of the 503nm pigment was inhibited. Fumarase, aconitase and glucose 6-phosphate dehydrogenase were de-repressed in E. coli B cells grown with excess of glucose in a medium containing 2,4-dinitrophenol. In air-oxidized, wild-type E. coli B cells, the 503nm pigment appeared before reduced cytochromes when gluconate was the substrate but failed to appear when succinate was the substrate. The results provide evidence for a role of the 503nm pigment in aerobic energy metabolism, possibly as an electron acceptor from NADPH.


Steroid hydroxylation and oxidative phosphorylation in human adrenal cortex mitochondria.


An analysis of the coronary vascular responses to catecholamines, using a modified Langendorff heart preparation. 1. A modified Langendorff heart preparation from the guinea-pig was used to analyse catecholamine responses. Contractile force, heart rate and coronary perfusion pressure were recorded.2. Four components of the vascular response could be identified.(a) The initial phase was a vasoconstriction mediated by alpha-adrenoceptors which preceded any effects on heart rate and force.(b) A secondary constriction followed, which was due to the increased myocardial compression during positive inotropic and chronotropic responses.(c) The third, more predominant, effect was a prolonged dilatation probably associated with the increased metabolic activity of the heart.(d) A fourth component was a direct vasodilatation mediated by beta-adrenoceptors which was evident when small doses of catecholamines were used but was usually masked by the more pronounced metabolically linked dilatation.3. The actions of salbutamol were examined and since it caused direct vasodilatation by stimulation of beta-adrenoceptors without other myocardial effects, these adrenoceptors were classified as the beta(2)-type.4. I.C.I. 50,172 was employed to block selectively the myocardial effects due to stimulation of beta(1)-adrenoceptors and leave the vasodilator beta(2)-adrenoceptors unaffected.5. Adrenaline, noradrenaline and isoprenaline were compared at two dose levels, in the presence or absence of effects on heart rate and force.6. Constrictor or dilator effects were found in the absence of other effects and were shown to depend to some extent on the rate of coronary perfusion.


Structure-activity relations for anticholinergic dioxolans.


Combined gas-liquid chromatography--mass spectrometry in the study of barbiturate metabolism.


The synthesis and anti-acetylcholinesterase activities of (plus)-physostigmine and (plus)-physovenine.


The actions of some non-steroidal drugs on lysosomes.


The stabilization-lysis action of anti-inflammatory steroids on lysosomes.


The effects of salicylate on the concentrations of amino-acids in mouse tissues.


Formulation and pharmacological studies of a controlled release pentagastrin injection.


Effects of diethyldithiocarbamate and carbon disulphide on brain tyrosine.


Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms.


Blockade of adrenergic transmission by dehydroemetine.


Uptake of [7,8-3H]dihyromorphine by rat cerebral cortical slices and eye tissue.


Vagotomy and atropine antagonism of (plus or minus)-chloroacetyl carnitine chloride mediated blood pressure reduction in the rat.


The uptake of anti-inflammatory steroids by lysosomes.


Amphetamine toxicity and endogenous noradrenaline concentrations in isolated and aggregated mice.


Effects of mescaline and 2,5-dimethoxy-4-methylphenethylamine on sleeping time in mice.


A comparison of the beta-adrenoceptor stimulant properties of salbutamol, orciprenaline and soterenol with those of isoprenaline.


A comparison of the stereochemical requirements of cholinergic and anticholinergic drugs.


Conformations in solution of some cholinergic and anticholinergic compouds.


The effect of amantadine on the uptake of dopamine and noradrenaline by rat brain homogenates.


The effect of prenylamine on adrenaline-induced hypercholesterolemia in mice.


On the mode of action of amantadine.

On the mode of action of amantadine.


Estimation of drug metabolite elimination kinetics in man by the synthesis-blocking method.


Limitations of liquid penetration in predicting the release of drugs from hard gelatin capsules.


The effect of ethanol and amphetamine mixtures on the activity of rats in a Y-maze.


Subconjunctival antibiotic therapy in ophthalmology with special consideration of the penicillins and cephalosporins.


[Progress in the field of drug development. 2].


Effect of proteolytic and lipolytic enzymes on the electron transport particle fraction of Rhodospirillum rubrum. I. Proteases.


Avidity of folic acid for carcinogenic metal ions aluminium(3), chromium(3), beryllium(II), lead(II) and uranium(VI).


Relationship between sensitivity to amytal inhibition and the content of nicotinamide nucleotides in rat-liver mitochondria following some uncoupling treatments.


A contribution to the problem of vascular changes in the rejected allotransplanted organs.


Prevalence of types of Diplococcus pneumoniae and their susceptibility to 30 antibiotics.


Effects of ganglionic blocking agents on the neuromuscular junction.


Cyclic AMP and adrenergic receptors in melanophore responses to methylxanthines.


Effect of ring substitution in 1-isopropylamino-3-phenoxypropan-2-ol on beta-adrenoceptor inhibition.


Aspects of the determination of biphenyl hydroxylase activity in liver homogenates. II. Sex and species differences in the effect of mitochondria.


Gunshot fractures in civilian practice. An evaluation of the results of limited surgical treatment.


Alterations in thyroid hormone economy during acute infection with Diplococcus pneumoniae in the rhesus monkey. In order to study the alterations in thyroid hormone economy that accompany an acute bacterial infection, rhesus monkeys were inoculated i.v. with a virulent Diplococcus pneumoniae culture containing approximately 10(8) organisms per dose. This was found to produce a well-defined febrile illness followed in most instances by spontaneous recovery, thereby permitting sequential observations to be made during progression from the healthy state through acute infection into convalescence. During the acute febrile period of the infection, the clearance of both exogenously labeled L-thyroxine (T(4)) and 3,3',5-triiodo-L-thyronine (T(3)) from their peripheral pools was accelerated. This alteration was often evident by 8 hr after inoculation with the virulent culture and could not be ascribed to a decrease in extracellular binding. Despite the accelerated hormonal clearance, the concentrations of both endogenously labeled thyroid hormone and stable T(4) in the sera of the surviving monkeys remained essentially unchanged or increased, indicating that hormonal secretion must have increased during this period. During the convalescent period, hormonal clearance was similar to preinfection control values. Leukocytes isolated from blood obtained 6 hr after inoculation with the virulent culture displayed enhanced T(4)-deiodinative activity.


Glutathione-dependent peroxidative metabolism in the alveolar macrophage. Phagocytosis by rabbit alveolar macrophages (AM) is accompanied by increases in O(2) consumption, glucose oxidation, and H(2)O(2) formation. Two aspects of the interrelations between these metabolic features of phagocytosis have been studied.First, the following evidence indicates that glutathione, glutathione reductase, and peroxidase serve as a cytoplasmic shuttle between H(2)O(2) and NADPH-dependent glucose oxidation: (a) AM contain 5.9 mmumoles of reduced glutathione per 10(6) cells and exhibit glutathione peroxidase and NADPH-specific glutathione reductase activity; (b) oxidized glutathione potentiates NADP stimulation of glucose oxidation; (c) an artificial H(2)O(2)-generating system stimulates glucose oxidation; (d) the cell penetrating thiol inhibitor, N-ethylmaleimide diminishes glucose oxidation. This effect largely depends on inhibition of the glutathione system rather than on inhibition of either H(2)O(2) formation or enzymes directly subserving glucose oxidation.Second, three potential H(2)O(2)-generating oxidases have been sought. No cyanide-insensitive NADH or NADPH oxidase activity could be detected. D-amino acid oxidase activity was 0.48 +/-0.07 U/10(6) cells with D-alanine as substrate.


The effect of temperature on the solubilities of testosterone propionate in low polarity solvents.


Cyclic adenosine 3',5'-monophosphate in human lymphocytes. Alterations after phytohemagglutinin stimulation. We have studied cyclic adenosine 3',5'-monophosphate (cyclic AMP) concentrations in human peripheral blood lymphocytes after stimulation with phytohemagglutinin (PHA), isoproterenol, prostaglandins, and aminophylline. Purified lymphocytes were obtained by nylon fiber chromatography, and low speed centrifugation to remove platelets. Cyclic AMP levels were determined by a highly sensitive radioimmunoassay. At concentrations of 0.1-1.0 mmoles/liter isoproterenol and aminophylline produced moderate increases in cyclic AMP concentrations, whereas prostaglandins produced marked elevations. High concentrations of PHA produced 25-300% increases in cyclic AMP levels, alterations being demonstrated within 1-2 min. The early changes in cyclic AMP concentration appear to precede previously reported metabolic changes in PHA-stimulated cells. After 6 hr cyclic AMP levels in PHA-stimulated cells had usually fallen to the levels of control cells. After 24 hr the level in PHA-stimulated cells was characteristically below that of the control cells. Adenyl cyclase, the enzyme which converts ATP to cyclic AMP, was measured in lymphocyte homogenates. Adenyl cyclase activity was rapidly stimulated by fluoride, isoproterenol, prostaglandins, and PHA. Since adenyl cyclase is characteristically localized in external cell membranes, our results are consistent with an initial action of PHA at this level.


An infrared study of solute-solvent interactions of testosterone propionate.


Temperature changes occurring during the compression and recompression of solids.


Adsorption of non-ionic surfactants at the griseofulvin-solution interface.


Nuclear magnetic resonance studies on micelle formation by promethazine hydrochloride.


The use of a bromide ion selective electrode for the measurement of counter-ion activity in cationic surfactant solutions.


The correlation of unsteady-state heat transfer data from a sterilizing oven.


Rheology of systems containing cetrimide-cetostearyl alcohol: variation with temperature.


Application of the Ferguson principle to the antibacterial activity of mono- and multi-component solutions of quaternary ammonium surface-active agents.


Grade variation in the rheology of white soft paraffin B.P.


On the release of drug from hard gelatin capsules.


The absorption, blood concentrations and excretion of pentazocine after oral, intramuscular or rectal administration to man.


Some observations on the ageing of sodium chloride compacts.


The effect of particle shape on the variation of fill of a tabletting die.


Preparation and characterization of the tropic acid esters of tropan-3-beta-ol, granatan-3-alpha-ol and granatan-3-beta-ol.


The compression properties of lactose.

The compression properties of lactose.


Pharmacognostical examination of the roots and stems of Rauwolfia mannii Stapf.


The alkaloidal pattern in the leaves, stem-bark and root-bark of Mitragyna species from Ghana.


The effect of antioxidants on the hydrolytic and oxidative degradation of sulphacetamide in aqueous solutions.


Effects of dietary protein deficiency on the conjugation of foreign compounds in rat liver.


Physico-chemical studies of analgesics. The protein-binding of some p-substituted acetanilides.


The effect of rate of loading on the strength of tablets.


The surface hardness of tablets.

The surface hardness of tablets.


An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry.


The compaction of magnesium carbonate.

The compaction of magnesium carbonate.


The influence of wet and dry granulation methods on the pore structure of lactose tablets.


Some observations of the penetration and disruption of tablets by water.


Effect of mescaline HCl on resistance of male mice to histamine stress.


Biochemical and genetic factors influencing drug metabolism. Influence of hepatic microsomal mixed function oxidation reactions on cellular metabolic control.


Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.


Emetics.

Emetics.


A computer-simulated model of an arthropod-borne virus transmission cycle, with special reference to Chikungunya virus.


A non-substrate effector of p-hydroxybenzoate hydroxylase.


Hepatic microsomal ethanol oxidizing system (MEOS): differentiation from alcohol dehydrogenase and NADPH oxidase.


Nursing--evolution or revolution?

Nursing--evolution or revolution?


The condition of the teeth in long term survivors of damage to the esophagus by caustic lye.


Lumbar hernia. An instance reported.

Lumbar hernia. An instance reported.


Mid-gut volvulus with malrotation.

Mid-gut volvulus with malrotation.


The view box.

The view box.


Hemodialysis, 1970.

Hemodialysis, 1970.


The medical student, the public and medical care.


The plans of our doctors in training. 2.


Hyperkineticism in children.

Hyperkineticism in children.


Effect of specific antibodies on the metabolism of guinea pig polymorphonuclear leukocytes.


An experimental study of the beta-receptor blocking agents on the cardiac performance in dogs.


Beta-adrenergic blocker, 2-(2-hydroxy-3-tert-butylaminopropoxy) chlorobenzene hydrochloride (D-69-12).


Response of dog's femoral artery strips to vasoactive substances.


Is there a place for the Aquarian nurse? 2.


Protection by catatoxic steroids against cycloheximide intoxication.


Effects of nicotine on cultured rat heart cells.


Cardiac stimulant 1-(hydroxyphenoxy)-3-isopropylamino-2-propanols.


Nurses expand role in child care.

Nurses expand role in child care.


Encephalitis with catatonic schizophrenic symptoms.


The wound that killed Lincoln.

The wound that killed Lincoln.


The plans of our doctors in training.

The plans of our doctors in training.


Binding of dimethylaminoazobenzene metabolites to DNA and proteins. I. In vitor studies on a microsomal dependent system.


Review of 1970 news. Association affairs.


Studies on P-450. VII. Reconstitution of a steroid 11-beta-hydroxulation system using a P-450 preparation extracted and partially purified from adenocortical mitochondria.


A nursing perspective of new partnership in health care.


On the etiology of hyaline membrane disease.


Effects of dietary modifications on caries in humans.


Changing responsibilities of allied health workers and the law.


A comparison of the cardiovascular effects of halothane, fluroxene, ether and cyclopropane in man: a resumé.


Heterologous antilymphocyte serum: a review.


Successful skin graft on renal allograft: report of a case.


Biochemical characteristics of insect microsomes: NADPH oxidation by intact microsomes from the housefly, Musca domestica.


New patterns of health care services advocated.


Psychological comparison of patients with cardiac neurotic chest pain and angina pectoris.


Localization of tyrosine transaminase in rat brain.


Sibling-sex-status and ordinal position effects on females' sport participation and interests.


The repression-sensitization scale and measures of prejudice.


Decision-making studies in patient management.


Metabolism of norethynodre, a 19-nor progestin: subcellular localization of enzyme activity. The subcellular distribution of the enzymes involved in the metabolism of norethynodrel (17 alpha-ethynyl-17 beta-hydroxy-estr-5(10)-en-3-one) to the 3alpha and 3beta diols (17 alpha-ethynyl-3alpha (or 3beta-17 beta-dihydroxy-estr-5(10)-ene)  and 17 alpha-ethinyl estradiol was studied.  The purity of the male rat liver subcellular fractions was evaluated by the use of marker enzymes.  Sample sections were viewed by electron microscopy.  The data showed that the cytosol fraction contained the highest relative specific activity for the hydroxysteroid dehydrogenases required for the formation of the diols.  The cytosol fraction also contained the highest total activity.  The enzymes required for the formation of ethinyl estradiol were distributed equally among mitochondrial and microsomal fractions, however, the highest relative specific activity was associated with the heavy microsomal fraction (18,000 g).


The changing face of dentistry in New Zealand.


Ten years of fluoridation in Lower Hutt.


Sympathomimetic bronchodilator preparations available in the United States.


Cytology and histology of haemopoietic cell transplantation under the influence of ALS in mice. II. The effect of marrow from donors pretreated with antilymphocyte serum (ALS) on the recipient.


Coronary flow changes and cardiac adrenergic blockade during nitroglycerin infusions.


Beta-adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines.


Role of catecholamines in inflammation.

Role of catecholamines in inflammation.


Anxiety and dental health in institutionalized delinquent adolescent.


Control of red cell glycolysis. The cause of triose phosphate accumulation.


Evaluation of a new antipsychotic agent. Piperacetazine (quide).


A kinetic study of the effect of alpha-D-galactose, alpha-D-mannose, alpha-D-glucosamine, N-acetyl-alpha-D-glucosamine, and alpha-D-ribose diphosphate on the activity of phosphoglucomutase.


Lymphocytes.

Lymphocytes.


Expression of differentiated functions in hepatoma cell hybrids. I. Tyrosine aminotransferase in hepatoma-fibroblast hybrids. The inducible enzyme tyrosine aminotransferase (TAT) has been investigated in hybrids between rat hepatoma cells and mouse fibroblasts. In the latter the TAT baseline activity is low, and in the presence of steroids does not change. By contrast, the hepatoma cells have high TAT activity, and this activity increases by a factor of 4-6 in the presence of steroids. The hybrid cells, like the fibroblasts, have low TAT activity and are not inducible. Heat inactivation curves demonstrate that the hybrid cells contain both parental forms of TAT, and therefore contain the parental genes specifying the enzyme. The presence in the hybrids of detectable rat TAT and the total absence of its inducibility suggest that a second gene is involved in the regulation of TAT inducibility, and that this gene is not expressed in the hybrids.


Possible mechanism of liver necrosis caused by aromatic organic compounds. Treatment of rats with phenobarbital, which stimulates the activity of the drug-metabolizing enzymes in the liver, potentiates hepatic necrosis elicited by bromobenzene and a number of other chemically inert halogenated aromatic hydrocarbons. Radioautographic studies indicate that [(14)C]bromobenzene is covalently bound at the sites of necrosis. From these results, it is inferred that the hepatotoxic effects of the halogenated aromatic hydrocarbons are mediated by chemically active metabolites formed in hepatocytes. In accord with this view, a number of aromatic halogenated hydrocarbons are converted by microsomes in vitro to active intermediates which form covalent complexes with glutathione (GSH).


Neurotransmitter-specific synaptosomes in rat corpus striatum: morphological variations. This communication describes ultrastructural variations among synaptosomal fractions isolated from the corpus striatum of the rat by incomplete equilibrium sedimentation in sucrose density gradients, and attempts to relate the variations to neurotransmitter-specific synaptosomes. The concentration of synaptosomes in each fraction of the density gradient was found to be correlated with the concentration of potassium, a marker for cytoplasm occluded within synaptosomes. Monoamine oxidase activity was found to be correlated with the incidence of free mitochondria in the gradients. Synaptosomes from denser gradient fractions showed a markedly increased frequency of adherent postsynaptic elements and intraterminal mitochondria. These denser gradient fractions were rich in synaptosomes containing norepinephrine, dopamine, serotonin, and acetylcholine, while synaptosomes in lighter portions of the gradients were rich in gamma-aminobutyric acid and other amino acids. These data suggest that significant morphological variations may exist among different neurotransmitter-specific nerve terminals in the brain.


Changes in renal blood flow during renal nerve stimulation.


Persistence of increased inducibility of NADP-linked dehydrogenases in rat liver.


Oxidized triphosphopyridine nucleotide specific isocitrate dehydrogenase from Azotobacter vinelandii. 3. The path of hydrogen in the enzymatic reaction.


Effect of cholestyramine on the terminal reactions of sterol biosynthesis.


Failure of etiological differentiation of human diseases associated with fibrinoid necrosis.


The effect of cycloheximide administration on vitamin K-stimulated prothrombin formation.


Homoisocitric dehydrogenase from yeast.

Homoisocitric dehydrogenase from yeast.


Melanosis of the skin, cause unknown. Jaundice secondary to ulcerative colitis.


Characterization of ferredoxin from nutsedge, Cyperus rotundus L., and other species with a high photosynthetic capacity.


The reduction of sulphite, nitrite and hydroxylamine by an enzyme from baker's yeast.


Particle fractionation from spinach leaf homogenates and diffusion of spinach protein factor.


Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.


Medicine must reply.

Medicine must reply.


Cellular aspects of aging: a review.

Cellular aspects of aging: a review.


The pathologic diagnosis of retorperitoneal fibrosis complicated by an aortic aneurysm.


Specificity in steroid histochemistry, with special reference to the use of steroid solvents. Distribution of 11-beta-Hydroxysteroiddehydrogenase in kidney and thymus from the mouse.


Functional hearing loss in children.

Functional hearing loss in children.


The management of headache.

The management of headache.


Gastrophotography.

Gastrophotography.


The general use of psychotropic drugs.

The general use of psychotropic drugs.


Tranquilizers in general practice: some practical hints.


Radiographic diagnosis of a urologic disease.


A little slice of death.

A little slice of death.


Cooperation--medical societies and industrial commissions.


Lead poisoning--a potential problem in all areas.


Actinomycosis of the appendix.

Actinomycosis of the appendix.


Oral contraception.

Oral contraception.


Recommendations for public health and school hearing conservation programs regarding hearing tests and criteria for failure and referral.


The third way.

The third way.


A worldwide commitment.

A worldwide commitment.


Air conservation: meeting the challenge.


The role of industry--air quality.

The role of industry--air quality.


Purposes and objectives.

Purposes and objectives.


Metabolism in vitro of diazinon and diazoxon in rat liver.


Recent beta-adrenoreceptor stimulants.

Recent beta-adrenoreceptor stimulants.


Beta-blockers in hypertension.

Beta-blockers in hypertension.


Oxidative metabolism of aldrin and isodrin by bean root fractions.


Further studies on the submitochondrial localization of cholesterol side chain-cleaving enzyme system in hog adrenal cortex by sonic treatment.


Early histological and histochemical changes in the heated and cryptorchid rat testis.


The laboratory transmission of Coxsackie A6 virus by mosquitoes. Coxsackie A 6 virus, strain V 29, originally isolated from Aedes polynesiensis in Fiji, was found to survive in A. australis for 5 days after intrathoracic injection and for 6 days after feeding on viraemic mice, and in Culiseta tonnoiri for 8 days after feeding.The virus level in both fed and injected mosquitoes fell steadily after infection and never exceeded the original level.No virus transmission was obtained in 46 successful second feedings on days 10-14 with A. australis, but three transmissions were obtained with C. tonnoiri, two on day 10 and one on day 13, from 12 successful second feedings.


Frequency response model of vagal control of heart rate in the cat.


Radioautographic evidence for equatorial wall growth in a gram-positive bacterium. Segregation of choline-3H-labeled teichoic acid.


Methapyrilene toxic psychosis mimicking eclampsia.


Morphologic and microbiologic features of trachea and lungs in germfree, defined-flora, conventional, and chronic respiratory disease-affected rats.


Comparative chronotropic activity of beta-adrenoceptive antagonists. 1. Chronotropic dose-response curves (non-cumulative) for beta-adrenoceptive antagonists were constructed from results in rats anaesthetized with pentobarbitone and depleted of catecholamines by pre-treatment with syrosingopine.2. Depletion of catecholamines lowered resting heart rate and reduced the threshold to the chronotropic action of isoprenaline by about 50%. Eight beta-adrenoceptive antagonists produced a dose-dependent chronotropic response but the maximum response was in all cases smaller than that obtained with isoprenaline. The order of activity was dichloroisoprenaline>LB 46>practolol>INPEA>oxprenolol>pronethalol>alprenolol>I.C.I. 45,763 (Kö 592). Propranolol and sotalol were without significant activity. The duration of the chronotropic response to the antagonists was more prolonged than that to isoprenaline. Propranolol caused a parallel shift to the right of the dose-response curves for the agonist effects of the antagonists.3. Estimation of beta-adrenoceptor blocking activity in anaesthetized cats gave an order of activity dissimilar to that found for maximum agonist responses: LB 46 > oxprenolol > alprenolol > propranolol > I.C.I. 45,763 > practolol > dichloroisoprenaline > sotalol > INPEA > pronethalol.4. Consideration of chemical structure and physico-chemical properties did not explain the differences between the agonist activities of the adrenoceptive antagonists.


Morphologic and microbiologic features of nasal cavity and middle ear in germfree, defined-flora, conventional, and chronic respiratory disease-affected rats.


The effects of "autonomic drugs" on villous movement in the small intestine of the pigeon. 1. The responses of pigeon duodenal villi to intravenous injection or local application of "autonomic drugs" were studied and compared with those reported in dogs by other workers.2. Choline esters, anticholinesterases, noradrenaline, adrenaline and nicotine all stimulated villous movement in the pigeon. Similar responses to these drugs have been reported in the dog. The effects of these drugs on villous activity could be inhibited by pretreatment of the bird with suitable antagonists, although hexamethonium was ineffective in preventing the effects of nicotine. Some of the antagonists also stimulated the villi.3. Isoprenaline caused inhibition of villous movements, which could be prevented by pretreatment of the bird with propranolol. It appears that in pigeons the villi have both alpha-adrenoceptors, stimulation of which increases villous activity, and beta-adrenoceptors, stimulation of which depresses villous movements.