On finding striated muscle in the brain. Well-developed striated muscle was found in the leptomeninges of a 2 day old infant with a 13-15 trisomy defect and multiple congenital anomalies. Except for arhinencephaly, minor sulcal abnormalities, and scattered microscopic cerebellar dysplasias the brain was well formed. The extreme rarity of this finding is noted and an attempt is made to explain it on an embryological basis. The implications of this observation in relation to some central nervous system tumours containing striated muscle are briefly discussed.


Comparison of median and ulnar sensory nerve action potentials in the diagnosis of the carpal tunnel syndrome. Recording of median and ulnar digital sensory nerve action potentials in normal subjects showed that the ratio of the median (index finger) to ulnar (little finger) potential amplitude was consistently greater than one. In 15 patients with the carpal tunnel syndrome (seven bilateral) this ratio was found to be less than one for all but two of the 22 clinically affected hands, including three of the four hands with a normal motor latency to threshold stimulation and four of the five hands with a normal sensory conduction. It is concluded that the estimation of the ratio of the median to ulnar sensory potential amplitude is a sensitive test in the diagnosis of the carpal tunnel syndrome and is particularly useful in those patients who show a normal motor latency and sensory conduction.


Pathological findings in a case of hypothyroidism with ataxia. A case of hypothyroidism with ataxia is described. At necropsy there were degenerative changes in the cerebellum, particularly in the anterosuperior portion of the vermis, together with atrophy of ventral portion of the pons, transverse pontine fibres, and middle and superior peduncles. The relationship between ataxia and pathological findings in myxoedema is discussed.


Folate metabolism in epileptic and psychiatric patients. Serum and red cell folate levels and serum vitamin B(12) levels have been estimated in 33 normal controls; 34 epileptic outpatients, 19 of whom also suffered from psychiatric illness; 33 epileptic inpatients with psychiatric illness; and 30 non-epileptic inpatients with psychiatric illness. Significant lowering of serum folate and red cell folate levels was observed in epileptic patients with psychiatric illness, and a less significant fall in red cell folate levels was found in non-epileptic psychiatric patients. Serum folate levels less than 2·5 ng/ml. were found in two controls, seven outpatient epileptics, 29 inpatients, and 10 non-epileptic patients. Red cell folate levels less than 100 ng/ml. were found in two controls, nine outpatient epileptics, 23 inpatient epileptics, and seven non-epileptic patients. A significant correlation was found between serum and red cell folate values in control, epileptic, and non-epileptic patients. In the epileptic patients there was a significant association between low serum and red cell folate levels and the presence of psychiatric illness. The origin and possible significance of these findings are discussed.


Stretch reflexes in the upper limb of spastic man. The reflex response to stretch has been studied in the upper limb of 20 spastic patients. The amplitude of reflex EMG was found to be closely related to the velocity of stretch. Reflex EMG in biceps and triceps muscles was augmented by increasing the length of the muscle, although minimal inhibition of reflex EMG in biceps was obtained in two patients by extreme stretch. The clasp-knife sensation in the upper limb cannot be related to autogenic inhibition but may be explained by the characteristics of a velocity-dependent reflex in which limb movement is braked by the mechanical effect of increasing muscle tension. It is suggested that this be called the pseudo-clasp-knife reaction to distinguish it from the clasp-knife phenomenon of the quadriceps muscle, since the underlying neurophysiological mechanism is quite different.


Effects of S, N and P on amino acid composition of field beans (Vicia faba) and responses of the biological value of the seed protein to S-amino acid content.


The use of the fatty acid composition of lipids in the identification of horse and kangaroo meat.


Changes in sugar phosphate and lactate concentration in trawled cod (Gadus callarias) muscle during frozen storage.


The anaerobic decomposition of ascorbic acid in the pH range of foods and in more acid solutions.


Effect of temperature on threshold values for citric acid, malic acid and quinine sulphate--energy of activation and extreme-value determination.


Extraction and analysis of free amino acids from sheep digesta.


Natural and synthetic sources of vitamin C.


Experimental graded "pump failure" of the left ventricle.


Hypoxia and acidosis in the blood-perfused dog heart.


The effect of truncal vagotomy on jejunal and ileal blood flow.


The effect of the pericardium on pressure-volume relations in the canine left ventricle.


Functional characteristics and lysosomal integrity of the isolated perfused cat pancreas.


Hydrodynamics of male micturition. I. Theory of steady flow through elastic-walled tubes.


Carbohydrate metabolism of the lung.

Carbohydrate metabolism of the lung.


Hydrodynamics of male micturition. II. Measurements of stream parameters and urethral elasticity.


Steady fluid flow through veins and collapsible tubes.


Continuous measurement of peripheral vascular resistance and circulatory function.


Fatigue fracture in the subchondral bone of the human cadaver femoral head.


Intracerebral electrode impedance plethysmography and regional cerebral blood flow.


Dynamic analysis of plastic below-knee drop foot braces.


A calculator controlled medical data acquisition system.


Determination of heart dipole vector P  electrically' and  magnetically'. Comparison.


The waveshape of action potentials recorded with different types of electromyographic needles.


Unit activity from peripheral nerve bundles utilizing correlation techniques.


Information processing in the central nervous system during functional electrical stimulation.


Absolute calibration of phonocardiographic microphones and measurements of chest wall vibration.


Programmable nanoampere constant current sources for iontophoresis.


An operating table plus head holder for rats.


A new apparatus for the simultaneous quantitative evaluation of several biological signals relevant to work physiology.


Baseline stabilization of physiological signals.


An active filter for A.C. bridges.

An active filter for A.C. bridges.


A system for manually or automatically controlled gustatory stimulation.


A simple linear transducer of physiological and pharmacological application.


An electronic delay circuit for biomedical simulations.


A rapid action, self-timing fraction collector.


Modification of a surfactometer for increased versatility.


Adverse effects of succinylcholine chloride.


Mortality experience of the community and of the fluorspar mining employees at St. Lawrence, Newfoundland.


Air pollution in the urban environment.

Air pollution in the urban environment.


Factors influencing the prognosis in myelomatosis.


The long-term treatment of hypertension with thiazide diuretics.


The use of amiloride hydrochloride in the correction of hypokalaemic alkalosis induced by diuretics.


Intravenous glucose tolerance in myocardial infarction.


Inappropriate secretion of antidiuretic hormone in Guillain-Barré syndrome.


Idiopathic retroperitoneal fibrosis.

Idiopathic retroperitoneal fibrosis.


Splenectomy for histiocytic medullary reticulosis.


Amoebic pericarditis.

Amoebic pericarditis.


Airway structure and alveolar emptying in the lungs of sea lions and dogs.


Temperate sprue.

Temperate sprue.


A contribution to the study of whole-blood Bohr effect in the alkaline range.


Gas to blood PCO 2  differences during rebreathing in children and adults.


The volume and rate of volume change of the swimbladder of the goldfish.


Concepts and basic quantities in gas exchange physiology.


Theoretical analysis of respiratory gas equilibration in water passing through fish gills.


Airflow dynamics in the avian lung as determined by direct and indirect methods.


Pathway of respired gas in the air sacs-lung apparatus of fowl and ducks.


Respiratory acidosis with partial metabolic compensation in chick embryo blood during normal development.


Effect of reducing the shell area on the respiratory properties of chicken embryonic blood.


Control of breathing in the exercising dog.


Diffusion constant for CO 2  through urinary bladders of cats.


A review and revision of the subfamily Epomidiostomatinae Skrjabin and Schulz 1937.


Experimental study on the correlation between the pancreas and parotid gland.


Histopathologic structure of adenocarcinomas induced in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine.


Reinnervation of the denervated muscle by direct nerve implantation in cats.


Postmortem blood microbiology using sterile autopsy technique.


Mycoplasmas (PPLO) and human neoplasms.

Mycoplasmas (PPLO) and human neoplasms.


Fine structure of the infiltrative cells in the lamina propria of the human nasal mucosa in allergy.


Effect of ingestion of food on adrenal 17-hydroxy-corticosteroid secretion in the dog.


Negative dromotropic response to phenylephrine blocked by phenoxybenzamine.


Metabolism of pyruvate and malate by isolated fat-cell mitochondria. 1. Metabolism of pyruvate and malate by isolated fat-cell mitochondria incubated in the presence of ADP and phosphate has been studied by measuring rates of pyruvate uptake, malate utilization or production, citrate production and oxygen consumption. From these measurements calculations of the flow rates through pyruvate carboxylase, pyruvate dehydrogenase and citrate cycle have been made under various conditions. 2. In the presence of bicarbonate, pyruvate was largely converted into citrate and malate and only about 10% was oxidized by the citrate cycle; citrate and malate outputs were linear after lag periods of 6-9min and 3min respectively, and no other end products of pyruvate metabolism were detected. On the further addition of malate or hydroxymalonate, the lag in the rate of citrate output was less marked but no net malate disappearance was detected. If, however, bicarbonate was omitted then net malate uptake was observed. Addition of butyl malonate was found to greatly inhibit the metabolism of pyruvate to citrate and malate in the presence of bicarbonate. 3. These results are in agreement with earlier conclusions that in adipose tissue acetyl units for fatty acid synthesis are transferred to the cytoplasm as citrate and that this transfer requires malate presumably for counter transport. They also support the view that oxaloacetate for citrate synthesis is preferentially formed from pyruvate through pyruvate carboxylase rather than malate through malate dehydrogenase and that the mitochondrial metabolism of citrate in fat-cells is restricted. The possible consequences of these conclusions are discussed. 4. Studies on the effects of additions of adenine nucleotides to pyruvate metabolism by isolated fat-cell mitochondria are consistent with inhibition of pyruvate carboxylase in the presence of ADP and pyruvate dehydrogenase in the presence of ATP.


Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones. 1. In epididymal adipose tissue synthesizing fatty acids from fructose in vitro, addition of insulin led to a moderate increase in fructose uptake, to a considerable increase in the flow of fructose carbon atoms to fatty acid, to a decrease in the steady-state concentration of lactate and pyruvate in the medium, and to net uptake of lactate and pyruvate from the medium. It is concluded that insulin accelerates a step in the span pyruvate-->fatty acid. 2. Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate. This suggested that insulin treatment of fat-cells led to persistent activation of pyruvate dehydrogenase. 3. Insulin treatment of epididymal fat-pads in vitro increased the activity of pyruvate dehydrogenase measured in extracts of the tissue even in the absence of added substrate; the activities of pyruvate carboxylase, citrate synthase, glutamate dehydrogenase, acetyl-CoA carboxylase, NADP-malate dehydrogenase and NAD-malate dehydrogenase were not changed by insulin. 4. The effect of insulin on pyruvate dehydrogenase activity was inhibited by adrenaline, adrenocorticotrophic hormone and dibutyryl cyclic AMP (6-N,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate). The effect of insulin was not reproduced by prostaglandin E(1), which like insulin may lower the tissue concentration of cyclic AMP (adenosine 3':5'-cyclic monophosphate) and inhibit lipolysis. 5. Adipose tissue pyruvate dehydrogenase in extracts of mitochondria is almost totally inactivated by incubation with ATP and can then be reactivated by incubation with 10mm-Mg(2+). In this respect its properties are similar to that of pyruvate dehydrogenase from heart and kidney where evidence has been given that inactivation and activation are catalysed by an ATP-dependent kinase and a Mg(2+)-dependent phosphatase. Evidence is given that insulin may act by increasing the proportion of active (dephosphorylated) pyruvate dehydrogenase. 6. Cyclic AMP could not be shown to influence the activity of pyruvate dehydrogenase in mitochondria under various conditions of incubation. 7. These results are discussed in relation to the control of fatty acid synthesis in adipose tissue and the role of cyclic AMP in mediating the effects of insulin on pyruvate dehydrogenase.


Pteridines produced by Methylococcus capsulatus. Isolation and identification of a neopterin 2':3'-phosphate. Three pteridines have been isolated from the methane- or methanol-oxidizing bacterium Methylococcus capsulatus. Two of these are known compounds, 2-amino-6-carboxy-4-hydroxypteridine and 2-amino-4-hydroxy-6-methylpteridine. The third is shown by degradative and synthetic experiments to be l-threo-neopterin 2':3'-phosphate. Labelling experiments show that both the pteridine moiety and phosphate residue are derived from a single GTP molecule. The possible metabolic significance of these compounds in methanol oxidation is discussed.


Lactate production in the perfused rat liver. 1. In aerobic conditions the isolated perfused liver from well-fed rats rapidly formed lactate from endogenous glycogen until the lactate concentration in the perfusion medium reached about 2mm (i.e. the concentration of lactate in blood in vivo) and then production ceased. Pyruvate was formed in proportion to the lactate, the [lactate]/[pyruvate] ratio remaining between 8 and 15. 2. The addition of 5mm- or 10mm-glucose did not affect lactate production, but 20mm- and 40mm-glucose greatly increased lactate production. This effect of high glucose concentration can be accounted for by the activity of glucokinase. 3. The perfused liver released glucose into the medium until the concentration was about 6mm. When 5mm- or 10mm-glucose was added to the medium much less glucose was released. 4. At high glucose concentrations (40mm) more glucose was taken up than lactate and pyruvate were produced; the excess of glucose was probably converted into glycogen. 5. In anaerobic conditions, livers of well-fed rats produced lactate at relatively high rates (2.5mumol/min per g wet wt.). Glucose was also rapidly released, at an initial rate of 3.2mumol/min per g wet wt. Both lactate and glucose production ceased when the liver glycogen was depleted. 6. Addition of 20mm-glucose increased the rate of anaerobic production of lactate. 7. d-Fructose also increased anaerobic production of lactate. In the presence of 20mm-fructose some glucose was formed anaerobically from fructose. 8. In the perfused liver from starved rats the rate of lactate formation was very low and the increase after addition of glucose and fructose was slight. 9. The glycolytic capacity of the liver from well-fed rats is equivalent to its capacity for fatty acid synthesis and it is pointed out that hepatic glycolysis (producing acetyl-CoA in aerobic conditions) is not primarily an energy-providing process but part of the mechanism converting carbohydrate into fat.


Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz( )anthracene 8,9-oxide and 10,11-dihydrobenz( )anthracene 8,9-oxide and their metabolism by rat liver preparations. The syntheses of 10,11-dihydrobenz[a]anthracene 8,9-oxide, benz[a]anthracene 8,9-oxide and 9-hydroxybenz[a]anthracene are described, together with those of a number of related compounds. The epoxides react both chemically and enzymically with water to yield the corresponding dihydrodiols and with reduced glutathione to form glutathione conjugates, and they react chemically with N-acetylcysteine to yield the corresponding mercapturic acids. 8,9-Dihydro-8,9-dihydroxybenz[a]anthracene, formed enzymically from benz[a]anthracene 8,9-oxide, was identical with a dihydrodiol formed when benz[a]anthracene was metabolized by rat liver homogenates. Similarly 10,11-dihydrobenz[a]anthracene 8,9-oxide yielded a dihydrodiol identical with the product formed when 10,11-dihydrobenz[a]anthracene was metabolized.


The identification of the site of action of NN'-dicyclohexylcarbodi-imide as a proteolipid in mitochondrial membranes. Mitochondrial membranes were incubated with NN'-dicyclohexyl[(14)C]carbodi-imide, which irreversibly inhibited the partial reactions of oxidative phosphorylation by 95-100%. Solutions of the membranes were analysed on polyacrylamide gels. Of the radioactivity recovered from the gels 90% was shown to be associated with a single protein of molecular weight about 10000. The radioactive protein and associated phospholipid was solubilized from the membrane by extraction with chloroform-methanol mixtures and was concentrated 50-fold by solvent fractionation and adsorption chromatography on Sephadex LH-20. Several protein-radioactivity peaks were obtained by Sephadex LH-20 chromatography. However, 90-100% of the radioactivity in each peak was shown to be associated with a single protein similar to the major radioactive protein observed in electrophoretograms of the membrane solutions. It is concluded that dicyclohexylcarbodi-imide inhibits mitochondrial oxidative phosphorylation by reacting covalently with a group on this chloroform-methanol-soluble protein. The possible role of this protein in oxidative phosphorylation is discussed.


The interaction of insulin with phospholipids. 1. A simple two-phase chloroform-aqueous buffer system was used to investigate the interaction of insulin with phospholipids and other amphipathic substances. 2. The distribution of (125)I-labelled insulin in this system was determined after incubation at 37 degrees C. Phosphatidic acid, dicetylphosphoric acid and, to a lesser extent, phosphatidylcholine and cetyltrimethylammonium bromide solubilized (125)I-labelled insulin in the chloroform phase, indicating the formation of chloroform-soluble insulin-phospholipid or insulin-amphipath complexes. Phosphatidylethanolamine, sphingomyelin, cholesterol, stearylamine and Triton X-100 were without effect. 3. Formation of insulin-phospholipid complex was confirmed by paper chromatography. 4. The two-phase system was adapted to act as a simple functional system with which to investigate possible effects of insulin on the structural and functional properties of phospholipid micelles in chloroform, by using the distribution of [(14)C]glucose between the two phases as a monitor of phospholipid-insulin interactions. The ability of phospholipids to solubilize [(14)C]glucose in chloroform increased in the order phosphatidylcholine<sphingomyelin<phosphatidylethanolamine<phosphatidic acid. Insulin decreased the [(14)C]glucose solubilized by phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, but not by sphingomyelin. 5. The significance of these results and the molecular requirements for the formation of insulin-phospholipid complexes in chloroform are discussed.


Biosynthesis of levan and a new method for the assay of levansucrase activity. The polysaccharide levan was synthesized in a solidified agar medium containing sucrose as a source of fructose. The biosynthesis was achieved by the enzyme levansucrase (2,6-fructan-d-glucose 6-fructosyltransferase, EC 2.4.1.10), a small quantity of which was placed in circular wells cut in the agar gel. The enzyme slowly diffused through the agar-sucrose medium and the synthesis of levan was observed as circular white areas, the size of which was dependent on the time of incubation and the concentration of enzyme used.


Determination of the sequences of protein-derived peptides and peptide mixtures by mass spectrometry. Micro-quantities of protein-derived peptides have been converted into N-acetylated permethyl derivatives, and their sequences determined by low-resolution mass spectrometry without prior knowledge of their amino acid compositions or lengths. A new strategy is suggested for the mass spectrometric sequencing of oligopeptides or proteins, involving gel filtration of protein hydrolysates and subsequent sequence analysis of peptide mixtures. Finally, results are given that demonstrate for the first time the use of mass spectrometry for the analysis of a protein-derived peptide mixture, again without prior knowledge of the protein or components within the mixture.


The effect of noradrenaline on glyceride synthesis and oxidative metabolism in vitro in the brown fat of newborn rabbits. 1. The effect of noradrenaline on the synthesis of glyceride from [U-(14)C]glucose and on gas exchange in the brown fat of newborn rabbits in vitro was investigated. 2. The specific radioactivity of l-glycerol 3-phosphate was lower than that of lactate, presumably because glycerol derived from glyceride was rephosphorylated by glycerokinase. 3. In the basal state more than 25% of the total respiration was due to pyruvate oxidation. Noradrenaline stimulated glyceride synthesis and total respiration without changing the proportion of the total respiration due to pyruvate oxidation. 4. The extra ADP released by noradrenaline stimulation of glyceride synthesis could not have supported more than 2% of the observed increase in substrate oxidation if mitochondria from brown-fat-cells remain fully coupled in the stimulated state, but could have supported about one-third of the observed increase if they become uncoupled in the presence of noradrenaline.


Mescaline-induced changes of brain-cortex ribosomes. Role of sperimidine in counteracting the destabilizing effect of mescaline of brain-cortex ribosomes. 1. The effect of spermidine on the mescaline-induced changes of brain-cortex ribosomes was studied by adding spermidine during the treatment of goat brain-cortex slices with mescaline. 2. Mescaline treatment of brain-cortex slices removed a portion of the endogenous spermidine from ribosomes and this removal was significantly prevented when spermidine was present during mescaline treatment. 3. Spermidine present during mescaline treatment of brain-cortex slices counteracted, to some extent, the destabilizing effect of mescaline on ribosomes with respect to heat denaturation. 4. Mescaline treatment of brain-cortex slices made ribosomes more susceptible to breakdown, releasing protein and RNA, and resulting in loss of ribosomal enzymic activities. However, spermidine present during mescaline treatment counteracted moderately the mescaline-induced ribosomal susceptibility to breakdown and ribosomal loss of enzymic activities. 5. Ribosomes of mescaline-treated cortex slices were rapidly degraded by ribonuclease and trypsin. However, if spermidine was present during mescaline treatment of brain-cortex slices the rates of degradation diminished.


Biosynthesis of the carbohydrate portions of immunoglobulin M. Incorporations of radioactive mannose, galactose and fucose into MOPC 104E mouse plasma-cell tumour suspensions suggest a stepwise addition of carbohydrate residues to immunoglobulin M (IgM) during the process of secretion. Mannose and glucosamine residues are added at an early stage, whereas galactose and fucose are added just before, or at the time that, IgM leaves the cell. Free light chains secreted in excess by the same tumour cells incubated with mannose, galactose or fucose contained barely detectable amounts of radioactivity.


Biosynthesis of the carbohydrate portion of immunoglobulins. Incorporation of radioactive fucose into immunoglobulin G1 synthesized and secreted by mouse plasma-cell tumour MOPC 21. Incorporation of radioactive fucose into the immunoglobulin G1 myeloma protein secreted by mouse plasma-cell tumour MOPC 21 is stereospecific for the l-isomer. Heavy chains of the secreted form of the myeloma protein carry 90% of the label in fucose residues of their carbohydrate moieties. A small but significant amount of the intracellular immunoglobulin G1 of the mouse plasma-cell tumour MOPC 21 appears to be labelled. Serum in the incubation medium supplies low-molecular-weight diffusible substances necessary to maintain continuous secretion of fucose-labelled myeloma protein beyond 2-3h, and of leucine-labelled myeloma protein beyond 6-8h. In medium containing extensively dialysed serum the secretion of leucine- and fucose-labelled myeloma protein can be restored by the addition of 250mum-d-mannose, 250mum-d-galactose and 250mum-glucosamine. Synthesis and secretion appear to be facilitated in the presence of these sugars, although secretion of myeloma protein devoid of terminal fucose residues is possible for a limited time-period.


The uptake and efflux of glycine from rat cerebral-cortex slices. The kinetics of the influx and efflux of radioactive l-glycine was studied in slices of rat cerebral cortex. The influx showed saturation kinetics and was inhibited by l-alanine. Influx was dependent on the presence of Na(+) ions and a metabolizable substrate. The efflux of glycine was accelerated by alanine. It was concluded that carrier-mediated facilitated diffusion was the mechanism of glycine uptake by, and efflux from, cerebral slices.


Allosteric activation of brain hexokinase by magnesium ions and by magnesium ion--adenosine triphosphate complex. 1. Substrate-saturation curves of brain hexokinase for MgATP(2-) were sigmoidal at sub-saturating concentrations of glucose when the Mg(2+)/ATP ratio was maintained at 1:1. Under identical conditions, except that Mg(2+) was present in excess, hyperbolic curves were observed. 2. The number of binding sites (calculated from Hill plots) is 1.8 at a Mg(2+)/ATP ratio 1:1, and 1.0 with excess of Mg(2+). The apparent K(m) for MgATP(2-) is 6.5x10(-4)m at a Mg(2+)/ATP ratio 1:1, and 3.5x10(-4)m with excess of Mg(2+). 3. Interdependence between substrate-binding sites was indicated by the effects of varying the concentration of glucose. The sigmoidality and deviation from Michaelis-Menten kinetics at a Mg(2+)/ATP ratio 1:1 became less pronounced with increasing glucose concentration. Also, although substrate-saturation curves for glucose were hyperbolic when the Mg(2+)/ATP ratio was 1:1, reciprocal plots were non-linear. These were linear with excess of Mg(2+). 4. High concentrations of Mg(2+) (Mg(2+)/ATP ratios above 5:1) were inhibitory. 5. The results are taken to indicate homotropic co-operative binding of MgATP(2-) and that Mg(2+) is an allosteric activator. Possible implications in regulation are discussed.


The conjugation of glutathione with unsaturated acyl thiol esters and the metabolic formation of S-carboxyalkylcysteines. The partial purification and properties of an enzyme from the soluble fraction of rat liver that catalyses the reaction of glutathione with 2,3-unsaturated acyl thiol esters is described, and its possible role in the formation of S-carboxyalkylcysteines is discussed. The synthesis of S-(3-methylcrotonyl)- and S-(2-methylcrotonyl)-N-acetylcysteamine and of S-crotonyl-NN-dimethylcysteamine hydrochloride and dicyclohexylammonium S-crotonyl-N-acetyl-l-cysteine is described.


Bilirubin glucuronyltransferase. Specific assay and kinetic studies. 1. Bilirubin glucuronide was synthesized in vitro in a system containing a rat liver microsomal fraction, UDP-glucuronic acid, Mg(2+) and bilirubin. The enzymic synthesis was accomplished without the addition of a bilirubin carrier. 2. Azobilirubin and azobilirubin glucuronide were separated by t.l.c. and paper chromatography and the measurement of the conjugate provided a specific assay for bilirubin UDP-glucuronyltransferase (EC 2.4.1.17). 3. This diazo compound was labelled when [U-(14)C]UDP-glucuronic acid was employed in the transglucuronidation reaction. 4. Identity of the glucuronide nature of the product was further confirmed by hydrolysis with beta-glucuronidase prepared from limpets and Helix pomatia. In each instance azobilirubin and glucuronic acid were liberated. 5. There was a close correlation between the bilirubin glucuronyl-transferase activity as measured by two procedures, colorimetric and radioisotopic. The specific activities so measured were 19nmol of bilirubin ;equivalents' conjugated/h per mg of protein and 16.9-18.4nmol of UDP-glucuronic acid incorporated/h per mg of protein, respectively. On this basis, it was concluded that the major product formed in vitro was bilirubin monoglucuronide; this represents about 77% of the total products formed. 6. The K(m) values for bilirubin and UDP-glucuronic acid at pH8.2 are 3.3x10(-4)m and 1.67x10(-3)m, respectively. 7. The addition of Mg(2+) at a final concentration of 5mm to the reaction mixture increased the rate of conjugation by 5.6-fold in the microsomal preparation that had been subjected to overnight dialysis against 10mm-EDTA (disodium salt). 8. Diethyl-nitrosamine at a final concentration of 1-20mm has no effect on the glucuronidation of bilirubin in vitro.


A reconstituted cell-free system for the specific transfer of steroid--receptor complexes into nuclear chromatin isolated from the rat ventral prostate gland. 1. A system has been developed for the specific transfer of [(3)H]dihydrotestosterone-receptor complexes into prostatic chromatin in vitro. 2. Under optimum conditions the overall transfer of [(3)H]dihydrotestosterone into purified chromatin in this reconstituted system is entirely consistent with the results obtained in whole tissue both in vivo and in vitro. 3. The transfer of [(3)H]dihydrotestosterone into chromatin is tissue-specific and maximal into chromatin isolated from androgen-dependent tissues. 4. The tissue specificity is maintained at two levels: first, in the presence of specific cytoplasmic androgen-receptor proteins; secondly, by the nature and composition of the chromatin itself. 5. Evidence is presented that androgenic steroids in vivo may maintain the tissue-specific nature of chromatin in androgen-dependent tissues by the selective induction of nuclear protein synthesis. 6. The relevance of these findings to the mechanism of action of androgenic steroids is discussed.


Calcium binding by human erythrocyte membranes. Significance of carboxyl, amino and thiol groups. 1. The role of the ionized carboxyl groups of proteins of the erythrocyte membrane as Ca(2+) receptor sites was investigated. A water-soluble carbodi-imide [1-cyclohexyl-3-(2-morpholinoethyl)carbodi-imide methotoluene-p-sulphonate], referred to as carbodi-imide reagent, and glycine methyl ester were used to modify the free carboxyl groups of the membrane. The degree of modification was estimated from amino acid analyses, which showed the amount of glycine incorporated. As the concentration of carbodi-imide reagent was raised (0.1-0.4m) incorporation of glycine increased and Ca(2+) binding decreased by about 77%. At 0.4m-carbodi-imide reagent all of the binding of Ca(2+) to protein was abolished and it was estimated that about 37% of the side-chain carboxyl groups of aspartic acid plus glutamic acid had been blocked by glycine. 2. Acetylation of all of the free amino groups was achieved by incubating the erythrocyte ;ghosts' at pH10.3 with acetic anhydride (10-15mg/10mg of ;ghost' protein). Acetylation increased by 1.5-fold the capacity of the ;ghost' to bind Ca(2+), indicating that the remaining carboxyl groups of aspartic acid and glutamic acid were made available for Ca(2+) binding by this procedure. These findings support the concept that in normal ;ghosts', at pH7.4, Ca(2+) binding to free carboxyl groups is partially hindered by the presence of charged amino groups. 3. Treatment of ;ghosts' with N-acetylneuraminidase, which removed 94% of sialic acid residues, and treatment with 1mm-p-chloromercuribenzoate did not alter Ca(2+) binding. The major effect of 5.8mm-p-chloromercuribenzoate upon ;ghosts' was to cause a solubilization of a calcium-membrane complex, which included about one-third of the ;ghost' protein. The molar ratio of Ca(2+): protein in the solubilized material was the same as that in the intact (untreated) ;ghosts'.


Digestion of an exogenous protein by rat yolk-sac cultured in vitro. Yolk-sacs were removed from 17.5-day pregnant rats injected 2-5h previously with (125)I-labelled bovine serum albumin. The specific activities of acid phosphatase and acid proteinase, and the specific radioactivities (trichloroacetic acid-insoluble and trichloroacetic acid-soluble) were measured in subcellular fractions prepared by homogenization and differential centrifugation. The conversion of acid-insoluble into acid-soluble radioactivity within cultured tissue was followed and the nature of the liberated products was investigated by gel chromatography. The results are consistent with the protein entering lysosomes and being digested there. The radiolabel was released chiefly as free iodotyrosine.


Further studies on the glycerol teichoic acid of walls of Staphylococcus lactis I3. Location of the phosphodiester groups and their susceptibility to hydrolysis with alkali. 1. The teichoic acid from walls of Staphylococcus lactis I3 is readily degraded in dilute alkali. 2. Degradation proceeds by selective hydrolysis of that phosphodiester group attached to an alcoholic hydroxyl group of the N-acetylglucosamine and gives a repeating unit in high yield. 3. Further studies on a different repeating unit isolated by partial acid hydrolysis have shown that the glycerol diphosphate is attached to the 4-hydroxyl group of the N-acetylglucosamine and not to the 3-hydroxyl group as was proposed earlier. 4. The susceptibility towards hydrolysis by alkali of other structural types of teichoic acid has been examined and found to vary markedly according to their structure.


The teichoic acids of Micrococcus sp. 24.


Cell-free biosynthesis of wool keratin proteins.


The turnover rate of noradrenergic vesicles.


Comparative biochemistry of chondroitin sulphate-proteins of cartilage and notochord. Fragments that consisted mainly of two polysaccharide chains joined by a short polypeptide bridge (doublets) were prepared from chondroitin sulphate-proteins of lamprey, sturgeon, elasmobranch and ox connective tissues after hydrolysis with trypsin and chymotrypsin. Consideration of molecular parameters, compositions and behaviour on gel electrophoresis and density-gradient fractionation leads to a proposed parent structure for chondroitin sulphate-proteins. A single polypeptide chain of about 2000 amino acid residues contains alternating short and long repeating sequences. A short sequence consists of less than 10 amino acid residues with one N-terminal and one C-terminal serine residue, each of which carries a polysaccharide chain linked glycosidically to its hydroxyl group. This structure constitutes the doublet subunit. Some variation is introduced when the doublet subunit carries only a single polysaccharide chain. The long sequence contains about 35 amino acid residues and is subject to cleavage by trypsin and chymotrypsin. The main polypeptide is probably homologous in the vertebrate sub-phylum with strong conservation of structure suggested for the short sequence. However, polymorphism of polypeptide structures cannot be excluded.


Multiple forms of mammalian deoxyribonucleic acid polymerase. An attempt to relate their interactions with nuclei and free deoxyribonucleic acid in vitro with their possible functions in vivo. THE DNA POLYMERASES OF THE FOLLOWING EUKARYOTIC TISSUES WERE STUDIED: regenerating rat liver, normal rat liver, rat thymus, normal mouse liver and Ehrlich ascites-tumour cells. In all cases two main polymerase forms are observed, one of mol.wt. 200000, preferring denatured DNA to native calf thymus DNA primer, designated type I, and the other, designated type II, of mol.wt. 100000, showing a variable and slight preference for native calf thymus DNA primer. Some catalytic properties of these polymerases are described. Nuclei have been isolated from some of these tissues by using two different buffer systems. The ionic composition of the isolation medium is found to affect greatly the amounts and types of polymerase that bind to the nuclei, and also affects the kinetic properties of the polymerases. The way the polymerases and nuclei change properties as the ionic composition of the buffers is changed suggests that ionic effects may be a significant factor in the control of DNA synthesis in vivo. These ionic effects also explain much of the previous confusion over the localization of specific DNA polymerases.


Testosterone action in the rat ventral prostate. The effects of diethylstilboestrol and cyproterone acetate on the metabolism of ( 3 H)testosterone and the retention of labelled metabolites by rat ventral prostate in vivo and in vitro. Recent reports have indicated that the prior metabolism of testosterone by the secondary sexual tissues may be necessary for its androgenic effect. The effects of two anti-androgens, diethylstilboestrol and cyproterone acetate (17alpha-acetoxy-6-chloro-1,2alpha-methylenepregna-4,6-diene-3,20-dione) used in the chemotherapy of human prostatic carcinoma, have been examined on both the metabolism of testosterone and the retention of its metabolites by the rat ventral prostate gland. Cyproterone acetate was found to inhibit the retention of labelled metabolites of [(3)H]-testosterone by prostatic nuclei, both in vivo and in vitro. This inhibition appeared to be competitive. In contrast with its effect on nuclear retention of metabolites of testosterone, cyproterone acetate had no significant effect on the metabolism of [(3)H]testosterone by rat ventral prostate tissue. Diethylstilboestrol similarly had little effect on the metabolism of [(3)H]testosterone by prostatic tissue, although it did appear partially to inhibit its initial metabolism in all the incubation systems used. Diethylstilboestrol inhibited the nuclear retention of dihydrotestosterone when both [(3)H]testosterone and diethylstilboestrol were injected intraperitoneally in vivo, but had no effect on dihydrotestosterone retention when both testosterone and diethylstilboestrol were supplied directly to the prostate either in vivo or in vitro. It was concluded that if diethylstilboestrol has an anti-androgenic effect at the level of the target organ as distinct from its effect on androgen production by the testes, then it is probably due to a mechanism differing from that of cyproterone acetate.


The association in vitro of polyribosomes with ribonuclease-treated derivatives of hepatic rough endoplasmic reticulum. Characteristics of the membrane binding sites and factors influencing association. 1. Pancreatic ribonuclease in dilute EDTA has been shown to condition rough-microsomal membranes from adult rat liver to accept exogenously added rat liver polyribosomes in vitro at 0-4 degrees C. Treated smooth membranes would not significantly interact with polyribosomes. 2. The conditioning process decreased the membrane RNA content and removed polyribosomes from vesicle surfaces as viewed electron-microscopically. 3. Binding to these conditioned membranes was shown to be uninfluenced by changes of temperature (0-37 degrees C) and pH (6.9-7.8) or the presence of cell sap, but was inhibited by increasing the concentration of potassium chloride. 4. Possession of a polyribosome-binding capacity by conditioned rough membranes was not dependent on adventitious materials that could be dislodged by high ionic strengths. 5. Trypsin treatment under mild conditions destroyed the binding capacity of ribonuclease-conditioned rough membranes. 6. A 2-10S residual RNA was recovered from ribonuclease-conditioned membranes, but its partial removal had no effect on the capacity of membranes to accept polyribosomes. However, some role for this residual RNA in attaching polyribosomes could not be discounted. 7. Evidence is considered that polyribosome-binding sites are intrinsic features of conditioned membranes isolated from rough-microsomal fractions, and that long-range ionic bonding is a primary factor in polyribosome interaction with these binding sites.


Comparison of some metabolic parameters in the perfused and the incubated rat diaphragm muscle with diaphragm muscle in vivo. 1. A method is described for perfusing the rat diaphragm muscle. 2. The following parameters were compared in both perfused and non-perfused incubated preparations: water content, sorbitol space, rate of lactate production, and the concentrations of tissue glucose, pyruvate, lactate, hexose phosphate intermediates, ATP and AMP. No significant differences were found. 3. Significant differences, however, were found on comparison of the tissue kept in vitro with the tissue in vivo. Immediately after removal of the tissue from the animal, the concentrations of the hexose phosphates and ATP were found to be much higher than after incubation or perfusion, and the concentrations of free glucose and of AMP were much lower, possibly indicating that the capacity for oxidative phosphorylation of glucose is impaired in vitro because of hypoxia.


The heterogeneity of uridine diphosphate glucuronyltransferase from rat liver. 1. The glucuronide conjugation of p-nitrophenol, phenolphthalein, o-aminophenol and 4-methylumbelliferone by rat liver microsomes has been studied. The detergent Triton X-100 activated UDP-glucuronyltransferase activity towards all these substrates, therefore the optimum activating concentration was added in all experiments. 2. Mg(2+) enhanced the conjugation of the substrates. 3. With phenolphthalein substrate inhibition occurred but this could be relieved by adding albumin, which binds excess of phenolphthalein. 4. Kinetic constants of the substrates and UDP-glucuronate have been determined. Mutual inhibition was found with the substrates p-nitrophenol, 4-methylumbelliferone and phenolphthalein. p-Nitrophenol conjugation was inhibited competitively by phenolphthalein and 4-methylumbelliferone. 5. o-Aminophenol did not inhibit the conjugation of the other three substrates because these are conjugated preferentially to o-aminophenol. 6. It is concluded that the four substrates are conjugated by one enzyme at the same active site.


The influence of insulin and of contraction on glucose metabolism in the perfused diaphragm muscle from normal and streptozotocin-treated rats. 1. The metabolism of [U-(14)C]glucose in perfused resting and contracting diaphragm muscle from normal rats and rats made diabetic with streptozotocin was studied in the presence and absence of insulin. 2. The incorporation of [U-(14)C]-glucose into glycogen and oligosaccharides was stimulated by insulin under all experimental conditions studied. 3. In the normal perfused resting diaphragm muscle the incorporation of radioactivity from [(14)C]glucose into lactate and CO(2) was not affected by insulin. 4. Periodic contractions, induced by electrical stimulation of the perfused diaphragm muscle in the absence of insulin, caused an increased incorporation of (14)C into glycogen and hexose phosphate esters, whereas incorporation of (14)C into lactate was greatly decreased. Production of (14)CO(2) in the contracting muscle was not significantly different from that in resting muscle. Addition of insulin to the perfusion liquid caused a further increase in formation of [(14)C]-glycogen in contracting muscle to values reached in the resting muscle in the presence of insulin. Formation of [(14)C]lactate was also stimulated by insulin, to values close to those found in the resting muscle in the presence of insulin. 5. In the diabetic resting muscle the rate of glucose metabolism was very low in the absence of insulin. Insulin increased formation of [(14)C]glycogen to the value found in normal muscle in the absence of insulin. Production of (14)CO(2) and formation of [(14)C]hexose phosphate remained unchanged. 6. In the diabetic contracting muscle production of (14)CO(2) was increased to values approaching those found in normal contracting muscle. Formation of [(14)C]lactate and [(14)C]glycogen was also increased by contraction, to normal values. Only traces of [(14)C]hexose phosphate were detectable. Addition of insulin to the perfusion medium stimulated formation of [(14)C]glycogen, to values found in normal contracting muscle. Production of [(14)C]hexose phosphate was stimulated by insulin, to approximately the values found in the normal contracting muscle. Production of (14)CO(2) and [(14)C]lactate, however, was not significantly affected by insulin. 7. These results indicate that the defects of glucose metabolism observed in perfused resting diabetic diaphragm muscle can be partially corrected by contraction, and in the presence of insulin the contracting diabetic muscle has a completely normal pattern of glycogen synthesis and lactate production, but CO(2) production remains impaired.


The early interference of liver carcinogens with protein synthesis and its possible bearing on the problem of tumor induction.


Determinants of toxicity.

Determinants of toxicity.


Rapid mitochondrial enlargement in muscle as a response to triamcinolone acetonide and its relationship to the ribosomal defect.


Inhibition of tryptophan oxygenase in vitro by steroid compounds.


Studies of oxygen dissociation in red cells with abnormal haemoglobins and some enzyme deficiencies.


Some realizations of (M,R)-systems and their interpretation.


Organismic supercategories and qualitative dynamics of systems.


Molecular set theory. 3. The wide sense kinetics of molecular sets.


Basic studies on metabolic steady state. Incompletely mixed systems.


Forecasting and chronic illness.

Forecasting and chronic illness.


Probabilistic and multiple regression modeling of the biologist's decision processes and its implications for medical diagnosis.


An in numero study of glucose-insulin interaction.


Wave propagation in bone media.

Wave propagation in bone media.


An autopsy case of the Klippel-Feil syndrome.


Studies on the placental polymorphic systems in Japanese.


Studies on antigen-antibody reaction in the kidney caused by anti-placental serum in pregnant and puerperal rabbits. II. Electron microscopic study of glomerular changes.


Experimental studies on the chemotherapy of open fracture. 3. the concentrations of kanendomycin (2'-amino-2'-deoxy-kanamycin) locally administered into the bone fracture hematoma.


Ectoparasites from three species of Spermophilus (Rodentia: Sciuridae) in Alberta.


Effect of host dietary constituents on intestinal pH and the migrational behavior of the rat tapeworm Hymenolepis diminuta.


Chromosomal basis of dosage compensation in Drosophila. V. Puffwise analysis of gene activity in the X-chromosome of male and female Drosophila hydei.


Salvage of patients in cardiogenic shock.


Combined adrenergic receptor blockade and circulating catecholamines in hemorrhagic shock.


Prolonged in vivo perfusion of rabbit kidneys with N-2-dihydroxyethylpiperazine-N-ethanesulphonic acid (HEPES).


Effects of hyperbaric oxygen, THAM and antibiotics on experimental burns in rats. Changes in body fluid compartments, electrolytes and acid-base balance.


Disappearance rate of xenon-133 from dog liver with different arterial routes of administration.


Red cell aggregation induced by a high molecular weight gelatin plasma substitute.


Fluorocarbon emulsion as a candidate for artificial blood. Correlation between particle size of the emulsion and acute toxicity.


Histochemical demonstration of sulphate groups by means of diaminobenzidine.


Influenza hemagglutination inhibition antibodies in Northern India.


Anti-streptolysin O test by microtechnique.


Histochemical evidence of chemical sympathectomy by guanethidine in newborn rats.


Histochemistry of non-specific phosphatases: the use of p-nitrophenyl phosphate and  -glycerophosphate as substrates.


Leukocyte culture for chromosome preparations using Eagle's minimum essential medium (MEM) Eagle's modified medium (EM) and Eagle's basal medium (BME).


Studies on the sandflies collected indoors in Aurangabad district Maharashtra state (Diptera: Psychodidae).


Cytopathogenicity of influenza viruses in chick mesoderm cell culture.


Usefulness of plasma ceruloplasmin and transferrin levels in the assessment of protein calorie malnutrition among pre-school children.


Suspected leptospirosis in goats.

Suspected leptospirosis in goats.


Value of serial blood volume measurements by hemolitre in major surgical procedures.


Utility of ascorbic acid in tetracycline therapy.


Epidemiology of peptic ulcer in an urban community in Chandigarh.


Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su.


Studies on peripheral metabolism of glucose and free fatty acids (forearm preparation) in various clinical types of Indian diabetics.


Study of sex chromatin in amniotic membranes of newborns.


Immunoglobulins in carcinoma cervix.

Immunoglobulins in carcinoma cervix.


Role of postural adjustments in conditioning of dogs with electrical stimulation of the motor cortex as the unconditioned stimulus.


Stimulus control in rabbits (Oryctolagus cuniculus) as a function of different intensities of intracranial stimulation.


Specificity of brain stimulation reward in the rat.


Contrasting development of visually triggered and guided movements in kittens with respect to interocular and interlimb equivalence.


Reward and aftereffects of reward in the learning of goldfish.


Behavior of the aquatic turtle (Chrysemys picta) on a modified visual cliff.


Acquisition, transfer, and reacquisition of single-alternation responding in the rat.


Pavlovian reconditioning and the recovery of avoidance behavior in rats after extinction with response prevention.


Differential classical conditioning in rabbits (Oryctolagus cuniculus) to tones and changes in illumination.


Coerced approach to shock, punishment of competing responses, and resistance to extinction in the rat.


Autonomic reactivity in the rat: effects of genetic selection for emotionality.


Trial spacing and emotionality in the rat.


Effect of housing density on the incidence audiogenic seizures in DBA-2J mice.


Dissociation of arousal and regulatory behaviors induced by hypertonic and hypovolemic thirst.


Quinine and saccharin preference-aversion threshold determinations in rats with septal ablations.


Vicious circle behavior in the rat: measurement problems visited again.


Effects of posttrial limbic stimulation on retention of a one-trial passive-avoidance response.


Numerical analysis of pressure and flow pulsations in a segment of the arterial tree.


A theoretical study of capacitive plethysmography.


Viscoelastic response of intervertebral disks at audiofrequencies.


An experimental stress analysis of the neck of the femur.


A more efficient waveform for cardiac stimulation.


A pacemaker digital electrocardiogram for accurate assessment of implanted cardiac pacemakers.


A microelectrode amplifier with novel frequency compensation.


The impedance of stainless-steel electrodes.


Monitoring of breathing with a segmental air-filled mattress.


A sine to square-wave converter for use in electromagnetic flowmetering.


An automatic device for the measurement of oedema in the feet of rats and guinea pigs.


Epilepsy associated with eating.

Epilepsy associated with eating.


Experimental urea-induced myoclonic seizures: mechanism and site of action.


Variation in response to anticonvulsants in a group of epileptic patients.


Reversal of organic brain syndrome with seizures and hyperuricosuria subsequent to allopurinol therapy.


Compression of EEG data.

Compression of EEG data.


Palinacousis of persistent auditory sensations.


Differential cerebral dominance to noise and verbal stimuli.


Giant cell arteritis (temporal arteritis).


Mechanisms of auditory comprehension. II. Cerebral dominance.


Transcortical motor aphasia associated with left frontal lobe infarction.


The minor cerebral hemisphere as a source of aphasic speech.


Correlates of facial recognition.

Correlates of facial recognition.


Dysprosody due to posterior fossa lesions.


Congenital myasthenia gravis in identical twins with crises in the newborn period.


A proposed biochemical mechanism for traumatic spinal cord hemorrhagic necrosis. Successful therapy for severe injuries by metabolic blockade.


Nervous system involvement as the heralding and-or major manifestation of infectious mononucleosis.


Thermography in migraine.

Thermography in migraine.


Tumor hyperthermia in the treatment of malignant gliomas of the brain.


Relative movement perception following unilateral cerebral damage.


Some ultrastructural observations in the floor of the IV ventricle of the rat and the cat.


Carotid-cavernous fistula: a technique for occlusion of fistula with preservation of carotid blood flow.


A cerebrospinal fluid transfer model for hepatic and uremic encephalopathy.


Lumbar CSF infusion test and shunt patency.


Remote effects, in time and place, of x-irradiation of the visual cortex in the monkey.


Familial neuromuscular disease with nonketotic hyperglycinemia.


Evaluation of periodic brain scanning in children with intracranial neoplasms.


The metabolism of orally administered L-dopa in Parkinson patients.


Multiple sclerosis and dental work.

Multiple sclerosis and dental work.


Experimental evaluation of L-dopa penetration in brain.


Synergism of levodopa by alpha methyldopa.


Raeder's benign paratrigeminal syndrome with dysgeusia.


Anterior spinal artery syndrome in young persons.


Edema formation within the spinal cord.

Edema formation within the spinal cord.


Cerebrotendinous xanthomatosis: in vivo labeling of cerebral sterols and sterol esters.


Neurophysiological studies in Batten's disease.


Manganese intoxication in the United States.


Electroencephalographic changes occurring during L-dopa treatment.


Spinal cord compression by vertebral acromegaly.


Electroencephalographic signs during cardiac surgery with morphine anesthesia and reversal with naloxone.


Cerebrovascular disease in an autopsy population. 4. Reduced frequency of stroke in patients with liver cirrhosis.


A genetic analysis of Parkinson's disease.


The ecologic implication of the neurologic effect of methylmercury.


The numerical impact of the major neurologic and sense organ disorders.


Neonatal white matter vulnerability: changes with time.


Positive criteria for the determination of electrocerebral silence.


New method for measuring regional cerebral blood flow and blood volume in man using the gamma camera.


The small lumbar canal: a suggested classification.


Regional cerebral blood flow response to hypercapnia in stroke.


An unusual neuromuscular defect in a case of possible botulism.


Amyotrophic lateral sclerosis: metabolism of central monoamines and treatment with L-dopa.


Cerebral embolism with cardiac myxoma: clinicopathological aspects.


Scanning electron microscopy of intracranial vessels.


Prognosis in amyotrophic lateral sclerosis.


Leptomeningeal metastasis from systemic cancer: a report of 47 cases.


Corticofugal antidromic activity in epileptogenic foci.


Cerebral spinal fluid lactic acid following circulatory arrest.


Non-resting tremor in Parkinson's disease.


Correlative study of EEG and brain scintiphotography.


The effects of acetylcholine and reticular stimulation on the motor cortex.


Conversion hysteria--a therapeutic opportunity for the neurologist.


On the effect of modulation of cerebral amine metabolism on the learning and memory of goldfish (Carassius auratus).


Development of criteria for the diagnosis of irreversible coma.


Measurement of cerebral blood flow during carotid endarterectomy.


Evaluation of patients undergoing therapy for gliomas by examination of CSF sterols after triparanol treatment.


The blood-brain barrier to several materials.


Distribution of diphenylhydantoin in rat brain: study with cellular and subcellular fractions.


A familial neurological disease with symptomatic response to levodopa.


Ion content, potassium efflux and cable properties of myotonic, human, external-intercostal muscle.


Experimental studies on the diagnostic (problem solving) skills of the neurologist and their implications for neurological traning.


Modification of L-dopa therapy of Parkinsonism by alpha-methyldopa hydrazine (MK-486).


Alpha-methyldopa as an adjunct to levodopa treatment of Parkinson's disease.


Sensory perineuritis.

Sensory perineuritis.


Immunological studies of sulfatase A in normals and in metachromatic leukodystrophy.


Neuronal activities in epileptogenic foci of immature cortex.


Effects of penicillin on cat motoneurons and guinea pig cerebral cortex slices.


Malaria infection in adult NZB mice and in adult (NZB x NZW) F 1  hybrid mice.


Acquired immunity to Plasmodium berghei yoelii in mice.


The effect of filariasis on the ability of a vector mosquito to fly and feed and to transmit the infection.


Measles vaccination: studies in methods and cost reduction in developing countries.


African histoplasmosis complicating pregnancy.


Experimental infection of Aedes aegypti and Aedes albopictus with dengue viruses.


Studies on the functional capacity of the tryptophanniacin pathway in bilharzial children from rural areas.


The propagation and survival of Trypanosoma brucei in vitro at 37 degrees C.


A new method of assessing the flea index of rats.


Amyloidosis as a manifestation of familial Mediterranean fever in siblings.


A lactose-free diet for malnutrition in rural Africa.


Some observations on experimental infection of cyclops with Ancylostoma caninum larvae.


Liver and yeast as larval diets in colonization of a sandfly (Phlebotomus longipes).


Synchronization of growth and division of rat-adapted Plasmodium vinckei chabaudi by photoperiodic rhythm.


Mebendazole (R-17,635): a new anthelmintic in the development of hookworms.


Haemoglobin changes in infected Biomphalaria glabrata.


Folate synthesis in Ae. aegypti and Drosophila melanogaster larvae.


Epidemiological significance of Strongyloides in sputum.


A case of congenital malaria.

A case of congenital malaria.


Diurnally sub-periodic microfilarial pattern in Brugia malayi in West Malaysia.


Treatment of Heterophyes heterophyes infections by radeverm.


The effect of metrifonate in vitro on Schistosoma haematobium and s. mansoni adults.


A dipole representation of the human visual cortex.


The human visual cortex as a system of four generators.


Incidence of "asbestos" bodies in basal lung smear. (A post-mortem study in residents of Sarajevo).


Protection of automobile occupants.

Protection of automobile occupants.


Similar sounds.

Similar sounds.


Community coronary care.

Community coronary care.


Author questioned: the patient with rheumatoid arthritis.


Some medical school applications data.

Some medical school applications data.


Perforated appendix in children.

Perforated appendix in children.


Recognizing scoliosis early.

Recognizing scoliosis early.


Retrocaval ureter.

Retrocaval ureter.


Clinical indications for propranolol.

Clinical indications for propranolol.


Degeneration behaviour of the cochlear nerve.


The effect of ionic concentration, metabolic inhibitors and high energy phosphate compound on the microphonic potential.


Least-cost diets in Cristalina, Goiăs, Brazil.


The uterus of the ewe. I. Secretion from the cannulated uterus.


Alterations in host metabolism by the specific and anorectic effects of the cattle tick (Boophilus microplus). 3. Metabolic implication of blood volume, body water, and carcass composition changes.


Effects of self-interaction of ligands on binding processes: studies with the acceptors firefly luciferase and thyroglobulin.


Ultrastructure of nuclear division in Paramecium aurella. I. Mitosis in the micronucleus.


Ultrastructure of nuclear division in Paramecium aurelia. II. Amitosis of the macronucleus.


Cell differentiation in the lower outer sheath of the Romney wool follicle: a companion cell layer.


New sunscreen preparations.

New sunscreen preparations.


Pattern of neutral polymorphism in a geographically structured population.


Multiple recombinational events within the 84W locus of Ascobolus immersus.


Meiotic disjunction in mouse translocations and the determination of centromere position.


The dispersal of Culex nigripalpus marked with high concentrations of radiophosphorus.


Survival of Rickettsia conori in nymphal Rhipicephalus sanguineus ticks at different temperatures.


Comments on the genus Neopsylla (Siphonaptera: hystrichopsyllidae) on Taiwan.


Anopheline mosquitoes of the Lanao Plateau, Philippines, and status of the local malaria vector (Diptera, Culicidae).


An automatic tick collector for studying the rhythmicity of "drop-off" in Ixodidae.


A new Ctenophthalmus (Siphonaptera: Hystrichopsyllidae) from voles on Taiwan.


Distribution of Leptotrombidium (Leptotrombidium) arenicola (Acarina: Trombiculidae) on the ground in West Malaysia.


The subgenus Persicargas (Ixodoidea, Argasidae, Argas). ll. Ecology and seasonal dynamics of A. (P.) arboreus Kaiser, Hoogstraal & Kohls in Egypt.


Daily and seasonal man-biting activity of phlebotomine sandflies in Panama.


The subgenus Persicargas (Ixodoidea, Argasidae, Argas). 12. Biological studies on the immature stages of A. (P.) arboreus Kaiser, Hoogstraal & Kohls in Egypt.


Ixodes hyatti, n. sp., and I. shahi, n. sp. (Acarina: Ixodidae), parasites of Pikas (Lagomorpha: Ochotonidae) in the Himalayas of Nepal and West Pakistan.


Ixodes (Ixodes) nuttallianus Schulze: redescription of female, description of male, and hosts and ecology in Nepal (Acarina: Ixodidae).


Trombicula jamesoni Brennan, 1948 (Acarina, Trombiculidae) placed in the genus Euschoengastia.


Two new species of Leptotrombidium (Ascarina, Trombiculidae) from Malaysia.


Female gynandromorphs of Lutzomyia trinidadensis Newstead from Panamá.


Foniatric cases in an ENT practice.

Foniatric cases in an ENT practice.


Intra-arterial chemotherapy with surgery or radiotherapy in tumours of the head-neck region.


Unusual presentation of a rhabdomyosarcoma of the ear.


On preservation of the posterior bony canal wall in middle ear surgery.


Introduction to the present state of medical speech pathology and speech therapy in Holland.


Neurophysiological aspects of the function and remobilization of paretic vocal cords.


Homograft myringoplasty with micro-sliced septal cartilage.


Decompression for 'malignant' exophthalmos.


The external ear canal and the middle ear cavity.


Eosinophilia in the practice of otolaryngology.


Growth regulation of the sympathetic nervous system: immunosympathectomy and chemical sympathectomy.


The renal handling of calcium in normal subjects and in renal disease.


[Role of triterpenes in the binding of L-amino acids by matricial RNA].


Distribution and turnover of serum albumin in various tissues of the mouse.


Monoamine oxidase activity in sympathetic ganglia and in peripheral tissues of newborn animals treated with 6-hydroxydopamine.


Substitution of the liver. I. A physiologic approach to the technique of isolated pig liver perfusion.


Chromosome aberrations in cultures of peripheral blood from personnel of a radiotherapy department.


The Factories Acts.

The Factories Acts.


An exposure to risk registry for compressed air workers.


Developmental changes in asbestos bodies and their significance.


The monitoring and control of industrial exposure to lead.


Carcass composition of Sudanese calves fattened on diets containing different levels of concentrates.


The use of human plasma in the blood incubation infectivity test to differentiate Trypanosoma brucei and Trypanosoma rhodesiense.


Symptoms and diagnosis of retroperitoneal fibrosis. Analysis of 31 cases.


The extra-vesical antireflux plasty. Statistical analysis.


Nonpenetrating traumatic rupture of thoracic aorta.


Fatal complications following inferior vena cava interruption.


Postmortem measurement of intercoronary anastomotic flow in normal and diseased hearts: a quantitative study.


Limb salvage by crossed femoro-popliteal shunt.


A thoracic window for incident light microscopy.


Metabolic changes in rat sceletal muscle after acute arterial occlusion.


Acute renal failure following ethyleneglycol poisoning. Report of three successfully treated cases.


Biological activity of carotid body tumours.


Effect of intravenously administered vasoactive substances on hepatic blood flow in experimental jaundice.


Combination of iridencleisis and cataract extraction.


Complex formation between macromolecules and drugs. V. A study of human serum albumin (HSA) binding of some 4-sulfanilamidopyrimidines and 2-sulfanilamidopyrimidines.


Complex formation between macromolecules and drugs. VI. Correlation of binding parameters for the binding of sulfa drugs to human serum albumin (HSA) with partition coefficients, thermodynamic values and quantum mechanical data.


Biosynthesis of tetrahydroisoquinoline alkaloids in Lophophora williamsii (Lem.) Coult.


The effect of microencapsulation with ethyl cellulose upon the disintegration in vivo and the dissolution of iron tablets.


Fibrin-stabilizing factor inhibitors. 3. Sulphonamides related to monodansylcadaverine.


Quantitative determinations by ion pair extraction. 7. Extraction of ionizable organic compounds with ion-pairing and adduct-forming agents.


Studies on arecaidine and quinuclidine derivatives--discovery of a sigmatropic rearrangement in the 2-dehydroquinuclidine system.


Anticonvulsant drugs. Benzylation of hydantoins using strong anion exchange resin.


Comparison between the U.S.P. 18 and the wet sieving disintegration tests.


The histology of the oviduct of domestic fowl in the course of the postincubation development. The development of the vagina.


Hereditary studies of congenital nystagmus in a Swedish population.


Prevalence and inheritance of congenital nystagmus in a Swedish population.


Some further data on the joint segregation of HL-A and haptoglobin.


Analysis of population structure. II. Two-dimensional stepping stone models of finite length and other geographically structured populations.


An inherited X-autosome translocation in man.


Genetic aspects of factor XIII deficiency.


Adenosine deaminase isozymes in human tissues.


Comparison of thermostabilities of different human placental alkaline phosphatase phenotypes.


Relatives of probands: models for preliminary genetic analysis.


The pathology of necrotic enteritis in domestic fowl.


Mutation frequency of red and clear plaque types of the Hickman strain of Newcastle disease virus.


Methods of isolating six mutant classes from the Hickman strain of Newcastle disease virus.


Gizzard erosion and ulceration in Peru broilers.


The Liverpool jacket.

The Liverpool jacket.


A comparison of intensive and longterm antibacterial treatment in patients with chronic pyelonephritis with renal failure.


Cor pulmonale in ankylosing spondylitis.


A checklist of parasites and diseases reported from the bobwhite quail.


Experience with clindamycin in common infections seen in general practice.


Multiple synchronous cancer of colon.

Multiple synchronous cancer of colon.


Incidence of tenosynovitis in Maine broilers.


Principal poultry diseases diagnosed, North Central Poultry Disease Conference Area, 1970.


Conservative management of renal masses.


Management of closed renal injuries.

Management of closed renal injuries.


Efficacy of sulfadimethoxine in turkey diseases.


Hypothermia in the conservative surgery of renal disease.


The long-term results of removal of staghorn calculi by extended pyelolithotomy without cooling or renal artery occlusion.


Angiographic characteristics of renal hamartoma.


The electrocardiogram of the turkey.

The electrocardiogram of the turkey.


Corrective operative procedure after unsuccessful pelvi-ureteric plastic surgery.


Report of the committee on nomenclature and reporting of diseases, Northeastern Conference on Avian Disease, June 1971.


The systemic effects of malignant renal tumours.


Ultrasonography of the urinary tract.

Ultrasonography of the urinary tract.


Chronic interstitial cystitis.

Chronic interstitial cystitis.


Persistence of parental infectious bursal disease antibody and its effect on susceptibility of young chickens.


A new concept in the management of carcinoma of the prostate.


Avian disease diagnoses in the Western States and Western Canada--1970.


Disease reports of the Southern Conference on Avian Diseases (SCAD) 1970.


"Estracyt".

"Estracyt".


Biochemic, serologic, and immunologic properties of isolates of Pasteurella multocida obtained from turkeys.


The incidence of deep vein thrombosis after prostatectomy.


Interrelationships in the metabolism of liver arachidonoyllecithins and plasma cholesteryl arachidonate in the rat.


On the structure of the renin inhibitor from hog kidney.


Cholesterol metabolism and vitamin B 6 . IV. Synthesis of cholic acid conjugates in vitamin B 6 -deficient rats.


Adenine as substrate for purine nucleoside phosphorylase.


Studies on plasminogen. IX. Purification of human plasminogen from Cohn fraction 3 by affinity chromatography.


Phosphorylation of histones in normal goose erythrocytes.


Circular dichroism properties of conalbumin and its iron and copper complexes.


Evaluation of methods for preparing proteins from plasma high density lipoproteins.


The mass spectrometric identification of the isomers of tyramine: identification of para-tyramine in rat brain.


Studies on chymotrypsin-P. I. Characterization.


Red-stained human bones from Qumran.

Red-stained human bones from Qumran.


Diurnal variations in calcium phosphate and calcium oxalate activity products in normal and stone-forming urines.


Calcium carbonate treatment of uremic acidosis.


Heart valve replacement. Seven years experience.


Vomiting during pregnancy in Jerusalem women.


Gastric secretion and acid output in the rat following hippocampal, septal and midbrain stimulation.


The acute effect of acid aspiration on lung mechanics and gas exchange in the rabbit.


Echinococcus granuiosus. Isolation and partial characterization of sRNA and DNA.


The balance of research, teaching and service in medical education.


Aspects of the purity control of drugs.

Aspects of the purity control of drugs.


Tuberculosis in Brent.

Tuberculosis in Brent.


The opportunist mycobacteria--a 20-year retrospect.


Tuberculous cervical lymphadenopathy.

Tuberculous cervical lymphadenopathy.


Tuberculin sensitivity in tuberculosis.

Tuberculin sensitivity in tuberculosis.


Spinal tuberculosis.

Spinal tuberculosis.


Potentially serious side-effects of high-dose twice-weekly rifampicin.


Problems of drug resistance in tuberculosis--the newer anti-tuberculosis drugs.


Tuberculosis in England and Wales in the next 20 years.


Future policy for BCG vaccination in Britain.


Breast cancer mortality in Yugoslavia.

Breast cancer mortality in Yugoslavia.


A premutational state induced in yeast by ethidium bromide.


A circular dichroism study of transketolase from baker's yeast.


Sequence and structure of a cysteinyl flavin peptide from monoamine oxidase.


Complete amino acid sequence of bovine neurophysin II.


The flavin of chromatium cytochrome C-552.


The structure of myo-inositol hexaphosphate dodecasodium salt octatriacontahydrate: a single crystal x-ray analysis.


Effect of estradiol-17  on collagen biosynthesis, degradation and re-utilization in vivo. The effects of estradiol-17beta on total body collagen metabolism were studied in adult female guinea pigs in which all collagen had been prelabelled by the chronic administration of -Lproline during the period of rapid growth.  Estradiol-17beta produced a decrease in collagen biosynthesis in skin in the presence of normal or increased collagen degredation.  Total carbon-14 label was unchanged in skin and in the granuloma.  Estradiol-17beta did not inhibit collagen biosynthesis in the granuloma; the content of soluable collagen was reduced.  Total uterine weight, collagen and noncollagenous protein were increased by estradiol-17beta, and the total carbon-14 label was markedly increased.  The wet weight and the dry, defatted weight of metaphyseal bone were increased by estradiol and the specific activity of hydroxyproline in collagen and proline in the noncollagenous protein was increased.


Arginine requirement for late mRNA transcription of vaccinia virus in KB cells.


Mechanism of the luminescent oxidation of cypridina luciferin.


Biosynthesis of yeast mitochondria. Drug effects on the petite negative yeast kluyveromyces lactis.


X-ray crystal structure of (Cu(adenineH) 2 Br 2 )Br 2 ; a copper complex involving non-bridging adenine.


RNA dependent DNA polymerase in cells of xeroderma pigmentosum.


A new method using 'proteinase K' to prevent mRNA degradation during isolation from HeLa cells.


Electrical properties of isolated cells of Necturus gastric mucosa.


Regulation of sugar transport in muscle: effect of increased external potassium in vitro.


The intestinal uptake and esterification, in vitro, of fatty acid as a diffusion limited process.


The number of Na + :K +  pump sites on red blood cells from HK and LK lambs.


The effects of ethanol and chlorpromazine on the passive membrane permeability to Na + .


Structural comparisons of native and reaggregated membranes from Mycoplasma laidlawii and erythrocytes by x-ray diffraction and nuclear magnetic resonance techniques.


Structural comparisons of native and reaggregated membranes from Mycoplasma laidawii and erythrocytes using a fluorescence probe.


Active F- transport: species and age effects with rodent intestine, in vitro.


Temperature effects on the proline transport system of Saccharomyces chevalieri.


On the location of I-anilino-8-naphthalene-sulfonate in lipid model systems. An x-ray diffraction study.


Stabilization and inactivation of biological membranes during freezing in the presence of amino acids.


Circular dichroism of biological membranes. I. Mitochondria and red blood cell ghosts.


Glucose transport carrier activities in extensively washed human red cell ghosts.


On the mechanism of mutual inhibition among sodium-dependent transport systems in the small intestine. A hypothesis.


Glycogen in isolated mucosal and serosal fractions of turtle bladder.


Disruption of mitochondrial membrane by acetone extraction.


19 F NMR of monofluorostearic acids in lecithin vesicles.


Reversal potentials of L-glutamate and the excitatory transmitter at the neuromuscular junction of the crayfish.


Studies on the sugar carrier in skeletal muscle: modification of carrier mobility by nitrogen mustard in vitro.


Amiloride, Ca 2+  and oxygen consumption of the urinary bladders of toads.


Vascular system of the optic nerve head and retina in the pig.


Early signs of the glaucomatous disc.

Early signs of the glaucomatous disc.


Urokinase in the management of traumatic hyphaema.


Corneal optical prostheses.

Corneal optical prostheses.


Bilateral oedema at the posterior pole. Hypersensitivity reaction to Alavac P injection.


Fluorescein fundus photography of angioid streaks.


Chorio-retinal hazards in aphakia.

Chorio-retinal hazards in aphakia.


Ocular effects of antifreeze poisoning.

Ocular effects of antifreeze poisoning.


Injury to the eye by the sap of Euphorbia royleana.


Miotics or mydriatics for atony of the ciliary muscle with delayed re-formation of anterior chamber after cataract extraction with complete iridectomy.


Impacted microfilaria in the lens capsule.


Stochastic treatment of cooperative specific adsorption.


Elastic deformation in orthotropic oval vessels: a mathematical model.


Possible origin of action potential and birefringence change in nerve axon.


Sporadic sustained nonperiodic oscillations in the activities of organismic sets.


A quantum model for controlled enzymic reactions. II. Controlled biochemical networks.


Confusions about the structures of nucleic acids.


Compertz curves, allometry and embryogenesis.


Synchronization of cell divisions in the fission yeast, Schizosaccharomyces pombe, using heat shocks.


The excretion of catecholamines in rats during acute and chronic exposure to altitude.


A new design of valve for rapid interruption of respiratory gas flow.


Immunoreactive rat growth hormone: physiological variations in serum and urine.


Amino acid imbalance and diet preference in the hypothalamic-hyperphagic rat.


Human serum pseudocholinesterases: molecular weight estimation of a subunit structure.


A contribution to the mechanism of the distribution of pulmonary blood flow in patients with mitral stenosis.


The pre- to post-capillary resistance ratio in the human forearm.


Sequential lowering and raising of brain gamma-aminobutyric acid levels by isonicotinic acid hydrazide.


Recovery after inadvertent massive overdosage of vincristine (NSC-67574).


Blood clearance of ICRF 159 (NSC-129943).


Influence of mitotic cycle inhibitors on the antileukemic activity of cytosine arabinoside (NSC-63878) in mice bearing leukemia L1210.


Vocal cord paralysis: a toxic reaction to vinblastine (NSC-49842) therapy.


Cerebellar ataxia during 5-fluorouracil (NSC-19893) therapy.


Induction of hyperplasia in mouse salivary gland isografts.


Cell free transmission of a plasmocytoma to various strains of adult mice.


Nucleic acids and acid-soluble derivatives released by isotonic solutions of cryoprotective agents from Ehrlich-Lettré ascites carcinoma and mouse spleen cells.


Effects of active specific and non-specific immunotherapy on E male G2 leukemia according to the route of administration and combination of immunological stimulants.


Contribution to the study of the Ehrlich-ascites tumor cells. A cytological and cytochemical analysis of the effects of sarcolysine.


Carcinoma of the bladder treated by preoperative irradiation followed by cystectomy.


Structure and activity in chemical carcinogenesis. Studies of variously substituted 7-bromomethylbenz(a)anthracenes.


Preliminary clinical screening with 6-aminochrysene in lung cancer. Cooperative group for clinical trials in lung cancer.


Measurement of the antitumoral immune reactions against a strain-specific chemically-induced sarcoma in syngeneic and F1 hybrid mice.


Inotropic effects of dexamethasone in mammalian heart muscle.


A study of the extraneural uptake of norepinephrine in the perfused heart of the guinea-pig.


Perivascular nerve degeneration produced in the hamster cheek pouch by 6-hydroxydopamine.


Antagonism of centrally mediated oxotremorine effects by a peripherally acting drug.


An attempt to correlate kinetic data on the drug receptor interaction with the chemical structures of cholinomimetic agents.


Catechol-o-methyl transferase and monamine oxidase activities in rat submaxillary gland: effects of ligation, sympathectomy and some drugs.


Degree and duration of prostaglandin E 1-induced inhibition of platelet aggregation in the rat.


A simple nerve bath and stimulator-unit for demonstrating the action of drugs on nerve.


Behavioral evidence for two types of cholinergic receptors in the C.N.S.


Dual effect of dexamphetamine on body temperature in the rat.


Uptake of morphine-3-glucuronide by choroid plexuses in vitro.


Role of brain acetylcholine and dopamine in acute neurotoxic effects of DDT.


Neuronal localization of dopamine, noradrenaline, and 5-hydroxytryptamine in the central and peripheral nervous system of Lumbricus terrestris (L.).


Electron microscopic and cytochemical study on the role of golgi elements and plasma membrane of enterocytes in the intestinal lipid transport.


Fine structural localization of acid phosphomonoesterase in the brush border region of osteoclasts.


Histochemical observations of alkaline phosphatase activity of the lingual epithelium after the suppression of salivation.


Association of coronary-prone behavior scores with recurrence of coronary heart disease.


Studies of mortality and morbidity data. I. An analysis of mortality data from some Canadian hospitals.


Spirometry using motivational techniques.


Tuberculin allergy and cancer risk.

Tuberculin allergy and cancer risk.


Affect levels and improvement in physical rehabilitation.


Satisfaction with medical care in a low income population.


The conservative management of rheumatoid arthritis.


Chromatography of carotenoid pigments from Sarcina lutea on sephadex LH-20.


Role of physical therapy and rehabilitation medicine in the management of chronic arthritis.


Investigations into rhizosphere microflora. I. Succession of microflora on root regions of Oryza sativa L.


Surgery and its place in the therapy of chronic arthritis.


The irritable colon syndrome.

The irritable colon syndrome.


Approaches to the patient with degenerative joint disease.


Medical management of chronic constipation.


Colostomy simplified.

Colostomy simplified.


Pruritus ani.

Pruritus ani.


Diarrhea: classification and treatment.

Diarrhea: classification and treatment.


Is a DVM a veterinarian?

Is a DVM a veterinarian?


Surgical management of urethral obstruction in male cats.


Use of wire sutures to stabilize fractures.


A new indwelling venous catheter.

A new indwelling venous catheter.


A massive chondrosarcoma in a poodle.

A massive chondrosarcoma in a poodle.


An attempt to assume absorption and excretion of lead in the healthy Japanese population.


Methemoglobinemia due to local anesthetics.


Effects of cataractogenic compounds, fatty acids and related compounds on cation transport of the incubated lens.


Perceptual conflict and alcoholics.

Perceptual conflict and alcoholics.


Subjective velocity estimates of apparent movement following visual stimulation.


Stutterers' perception of time-compressed speech.


Serial learning of CVC combinations with high and low social-content ratings by schizophrenics and normals.


Phonetic correlates of graphic recall.

Phonetic correlates of graphic recall.


Performance of malnourished rats on the Hebb-Williams closed-field maze learning task.


Effect of relative positions of segments on strength of the Mueller-Lyer illusion.


Salivary response to lemon juice as a measure of introversion in children.


Effect of stimulus-change method on tactile-image recognition.


Effects of symbolic verbalization by the model on children's observational learning.


Color preference as a function of background and illumination.


Scores made by retarded readers on the Holtzman Inkblot Technique.


Normative study of oral and non-oral structures using vibrotactile stimuli.


WAIS-predicted category test scores with the Halstead neuropsychological battery.


Extraversion, anxiety, creativity and grades.


Measuring spatial aptitudes of the retarded.


Accounting for sex differences on the rod-and-frame test.


High self-esteem and identification with adult models among economically deprived children.


Multi-modality responding as a function of mental age of retardates.


Basal skin resistance of premature infants.


Relations among chronicity, diagnosis, premorbid adjustment, defensiveness and two measures of perceptual scanning.


Apparent brightness of gapped and non-gapped moving lines.


Non-verbal rigidity and academic achievement in high school and college.


Pain and distraction in athletes and non-athletes.


Field dependence and Rorschach white-space figure-ground reversal responses.


Uncertain pain and the pain of uncertainty.


Stress and flicker perception. I. The effects of shock induced anxiety.


Visual-field restrictions in cases of reading disability.


Expectancy as a factor in reaction to delayed auditory feedback.


Field dependence-independence as related to college curricula.


On the enlargement of acute angles.

On the enlargement of acute angles.


Effects of distance and retinal velocity on duration of spiral aftereffect.


Halstead's Category Test and lateralized brain damage.


Comparison of task-central and task-peripheral forms of the Canter-BIP in diagnosing brain damage in adults.


Awareness of the back of the body and homosexual impulses.


Relationships among Raven progressive matrices avoidable and atypical errors and Bender Gestalt errors.


Contiguity of placebo administration and misattribution.


Naming of meaningful nonverbal sounds by blind children.


Two tests of psychomotor function in detection of organic cerebral damage in elderly psychiatric patients.


Verbal intelligence and susceptibility to visual illusions.


Variations in body image as a function of achievement level in school performance.


Psychomotor performances of patients undergoing L-dopa therapy.


Spatial perception of highly skilled and poorly skilled females.


Eye orientation during visual discrimination learning by humans.


A simple method for modifying a standard activity wheel to increase sensitivity.


Factor analyses of the de Hirsch Predictive Index.


Accuracy of predicting reaction and movement times of a gross motor performance from the dominant hand under simple and choice stimulus conditions.


Hue-tone sensory interaction: a negative result.


Individual differences in attention and the prediction of flight criteria.


The isolation and characterization of the lamellar body of bovine lung.


Visual acuity and stimulus area.

Visual acuity and stimulus area.


Heart rate deceleration after erroneous responses. A phenomenon complicating the use of heart rate variability for assessing mental load.


The significance of crossed and uncrossed projections for the acquisition and retrieval of visual engrams in hooded and albino rats.


Directional separation and the size cue to distance.


Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty.


The action of lauryl-sulfate on the activation of contraction in frog skeletal muscle. The potentiation of potassium contractures by low concentrations of lauryl-sulfate.


Relationship between antral acidity and gastrin releasing potency of chemical stimulants.


Adrenergic innervation and drug responses of the oval sphincter in the swimbladder of the cod (Gadus morhua).


The effect of arterial hypoxemia upon acid-base parameters in arterial blood and cisternal cerebrospinal fluid of the rat.


Endogenous inhibition of the mechanical response of the isolated rat and guinea-pig vas deferens to pre- and postganglionic nerve stimulation.


Impulse activity of the isolated spindle in potassium-free solution.


Interaction between the fastigial pressor response and the baroreceptor reflex.


The effect of stomach distension on the efferent activity in the chorda tympani nerve of the rat.


The hemodynamic consequences of regional hypotension in spontaneously hypertensive and normotensive rats.


Differences in the antidiuretic response to intracarotid infusions of various hypertonic solutions in the conscious goat.


Heart rate in relation to sympathetic efferentation associated with the Bainbridge reflex in dogs.


Perfusate qualities and spontaneous edema formation in an isolated perfused lung preparation.


Histomorphological studies of the salivary glands in normal male and castrated pigeons.


The activity of N-acetylglucosamine kinase from human gastric mucosa.


Cystine metabolism in vitamin B 6  deficiency: evidence of multiple taurine pools.


Unstable hemoglobin hemolytic anemia: in vitro incubation studies on erythrocytes with hemoglobin Sabine.


Charcoal-catalyzed oxidation of creatinine to methylguanidine.


Activation of phenylalanine hydroxylase by phenylalanine.


Maltase, isomaltase and glucoamylase activities of the acid alpha-D-glucoside glucohydrolase isolated from cattle liver.


Four forms of human pancreatic procarboxypeptidase A demonstrated by isoelectric focusing.


Renal dipeptidase: localization and inhibition.


Electrophoretic and chromatographic separation of phosphoenolpyruvate carboxykinases.


A proposed structure for the  330 -nm chromophore of glutamate decarboxylase and other pyridoxal 5'-phosphate dependent enzymes.


Glyoxylate carboxy-lyase activity in the unicellular green alga Gloeomonas sp.


A second-order kinetic reaction catalyzed by riboflavin synthetase from a high-riboflavinogenic Eremothecium ashbyii.


Experimental rabbit syphilis.

Experimental rabbit syphilis.


Pancreatic juice co-lipase: physiological importance.


Nerve deafness in early syphilis.

Nerve deafness in early syphilis.


Inhibition of growth of treponemes by antimicrobial agents.


Treatment of acute gonorrhoea with a single oral dose of rifampicin.


Asymptomatic non-specific urethritis.

Asymptomatic non-specific urethritis.


A comparison of serological tests for the diagnosis of gonorrhoea.


Continued efficacy of streptomycin in the treatment of granuloma inguinale.


On the variability of conduction velocity measurements on repeated examinations.


Investigation of gait. 2. Gait analysis in normal individuals.


Some data and problems relating to electromyographic investigations of patients with infantile cerebral paralysis.


The jaw opening reflex in man.

The jaw opening reflex in man.


Computer assisted on line measurement of motor unit potential parameters in human electromyography.


A case of cholesterol pleurisy with special reference to lipid analysis of the serum and pleuiral fluid.


Comparative embryological study on the abnormal development of adrenohypophyseal system.


Effect of malnutrition on head growth. (Preliminary communication).


Anaphylactoid purpura associated with smallpox vaccination.


Isolation of virulent Paracolobactrum aerogenoides microorganisms from a rat.


Neonatal bilirubinaemia and its relationship to long term neurological deficits.


Biochemical alterations associated with pneumonia in infancy and childhood.


Study of maternal factors in relation to birth weight and gestational age of the new born.


Lung puncture : aid to bacteriological diagnosis of pulmonary tuberculosis in children.


Variability in interpretation of clinical signs by trained pediatricians.


L-dopa and parkinsonism.

L-dopa and parkinsonism.


Alport's syndrome (familial nephropathy with deafness).


Infectious endocarditis.

Infectious endocarditis.


Random observations.

Random observations.


Alcohol and drug abuse in Hawaii.

Alcohol and drug abuse in Hawaii.


Congenital heart disease in childhood--a clinical study.


A note on system modelling, aggregation and reductionism.


X-ray view box.

X-ray view box.


Mathematical simulation of the electroencephalogram using an autoregressive series.


The analysis of dental surveys using the computer.


Life's window--the pupil.

Life's window--the pupil.


A model for the diffusion of information by synapsis.


Socialization and conformity.

Socialization and conformity.


Drop-off rhythms of engorged rabbit ticks, Haemaphysalis Leporispalustris (Packard, 1896) (Acari: Ixodidae).


Water balance in the lone star Tick (Acarina: Ixodidae): the effects of relative humidity and temperature on weight changes and total water content.


Taste receptors of the mosquito Anopheles atroparvus Van Thiel.


Arthropod parasites collected from white-tailed deer.


A modification of the washing technique for quantitative evaluation of the ectoparasite load of small mammals.


Comparative survival, weights, and pupation rates of four Aedes Aegypti (L.) strains reared with a standard technique.


The effects of diet on life-span, fecundity and flight potential of Aedes taeniorhynchus adults.


Comments on Eudusbabekia, new name (Jamesonia Dusbábek, 1967, preoccupied), with two new species (Acarina: Myobiidae).


Transstadial (nymph-to-adult) infection of Anaplasma marginale in Dermacentor andersoni Stiles.


Biochemical and physiological studies of certain ticks (Ixodoidea). The sugar content and concentration in Argas and Hyalomma biological fluids.


Response of ovipositing Amblyomma maculatum Koch (Acarina: Ixodidae) to photoperiod.


Biochemical and physiological studies of certain ticks (Ixodoidea). Total free amino acids in gut, hemolymph, and coxal fluids of Argas (Persicargas) Persicus (Oken) and A. (P.) arboreus Kaiser, Hoogstraal & Kohls (Argasidae).


Blood-feeding patterns of midges of the Culicoides variipennis complex in Kern County, California.


Plague vector studies. I. The rate of transfer of fleas among Citellus, Rattus and Sylvilagus under field conditions in southern California.


Plague vector studies. II. The role of climatic factors in determining seasonal fluctuations of flea species associated with the California ground squirrel.


Sexual sterilization of screwworm flies: further studies of reliability of the chemosterilant technique.


Studies on autogeny in natural populations of Culex pipiens. II. Seasonal abundance of autogenous and anautogenous populations.


Chiggers of the genus Helenicula of the Old World including descriptions of 9 new species (Acarina: Prostigmata, Trombiculidae).


Genetic incompatibility and hybridization studies on two members of the Culex pipiens complex.


Anomalaspis ambiguus Brennan, 1952 redescribed and the questionable association of South American species with pseudoschoengastia (Acarina: Trombiculidae).


Adult flight activities of some British Culicoides species.


A large-scale artificial feeding technique for infecting mosquitoes and its application to screening antimalarial chemicals.


A simple method for obtaining a circadian temperature cycle from an air conditioner in an insectarium.


Inhibitors of protein synthesis involved in memory disruption. A study of their effects on sympathetic ganglion isolated in vitro.


Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brain.


Influx of glutamic acid in peripheal nerve. Energy, ionic, and PH dependence.


Effects of halothane and colchicine on microtubules and electrical activity of rabbit vagus nerves.


Phospholipid biosynthesis in the intestinal wall and relevant role o glycerol.


Cholesterol esterification from dietary fatty acids in intestinal wall.


Obesity in the Japanese: its prevalence and major complications.


Familial occurrence of obesity: an observation about height and weight of college women and their parents.


Angiotomography in cerebral angiography.


Studies on the numerical changes of the lymphocytes in the efferent lymphatics with lymphogenously given antigen.


Studies on the biological background of the sprouting of the vessels--its relations to the plasma exudation.


A pharmacological study of N-( -(p-l-hydroxypropyl)phenoxyethyl)-l-phenyl-2-aminopropane.


L-Amino acid inhibition of epinephrine-induced hyperglycemia.


Interaction between 5-dimethylaminonaphthalene-l-sulfonamide and human serum albumin.


Poisoning in the United States.

Poisoning in the United States.


Inhibition of the function of human blood platelets in vitro by VK 744.


Observations on cryopreservation of lymphocytes in chronic lymphocytic leukaemia and normal human lymphocytes.


Thrombotest and the diagnosis of disseminated intravascular coagulation (DIC).


Alternating appearance of IgD and IgG myeloma protein during treatment.


Leucopoietic properties of four different androgenic hormones in irradiated rats.


Myelosclerosis and paroxysmal nocturnal haemoglobinuria.


Congenital sideroblastic anaemia in a girl.


Thrombocytopenia in rabbits induced by heparin, protamine, and polybrene.


Primperan and its side-effects.

Primperan and its side-effects.


Inactivation of human chorionic gonadotropin extracted from chorionic tissue and serum by neuraminidase.


Renal arteriography in standing position for movable kidney.


Cytological studies on the enterochromaffin cells in the intestinal metaplasia.


Histometrical studies of the pulmonary artery in sudden death of young and apparently healthy subjects.


Submucosal extension with spherical appearance of esophageal carcinoma into gastric cardia--clinico-pathologic study of four cases.


A device for automatic plotting of the atrioventricular conduction time.


Studies on radioactive iodination of fluorescein isothiocyanate.


Measurement of collateral flow at quasialveolar level in excised dog lung.


The next ten years of meat hygiene.

The next ten years of meat hygiene.


Antibiotics and calf diarrhoea--the effect of serum immune globulin concentrations.


What industry expects of its training.

What industry expects of its training.


The illegal sale of veterinary antibiotics.


A maturation requirement for strongyle larvae.


Massive liver necrosis in pregnancy.

Massive liver necrosis in pregnancy.


The electrocardiogram in endomyocardial fibrosis.


The daily urinary volume, sodium and potassium in adult Ghanaians.


Experience with CI-581 (Ketamine). Value as an induction agent and analgesic supplementation of light general anaesthesia.


Hepatic amoebiasis with jaundice.

Hepatic amoebiasis with jaundice.


Typhoid fever in Ilesha, Western State, Nigeria.


Cardiac and renal involvement in mumps.

Cardiac and renal involvement in mumps.


The in vitro transformation of progesterone by Rhizopus nigricans REF 129.


Effects of some chemical mutagens on survival and reversion of some mutant strains of Fusarium spec.


Transfer of the primary induction stimulus by small numbers of amphibian ectoderm cells.


Effects of phosphate upon CO binding kinetics and NMR spectra of hemoglobin valency hybrids.


Retention of in vitro biological activities by desialylated human luteinizing hormone and chorionic gonadotropin.


Investigation on the mechanism of acylase-I-catalyzed acylamino acid hydrolysis.


Comparative properties of human erythrocyte sialoglycopeptides released by trypsin.


Glycogenolysis and glycogen synthesis in a cell-free system from rat liver.