Carriers and specificity in membranes. V. Neuron membranes. High resolution electron microscopy applied to the study of nerve membranes.


Carriers and specificity in membranes. VI. Biological flow structure and their relation to chemicodiffusional coupling.


Carriers and specificity in membranes. VII. Final remarks.


The haematology and histopathology of Trypanosoma congolense infection in cattle. 3. Discussion and conclusions.


The haematology and histopathology of Trypanosoma congolense infection in cattle. I. Introduction and histopathology.


The aparasitaemic interval following diminazine aceturate therapy of a relapsing strain of T. vivax infecting cattle.


Isolation and ultramicro determination of hydrogen sulphide in air or water by use of ion-exchange resin.


A quantitative in situ fluorimetric study of acridine and 5,6-benzoquinoline after thin-layer chromatographic separation from similar air pollutants.


Determination of lead in a minute blood sample by the spectrophotometric method.


Determination of copper(II) and zinc(II) in blood by spectrophotometry and polarographic methods.


Determination of beta-mercaptopyruvic acid in cysteine transamination mixture by titration with o-hydroxymercuribenzoic acid using dithiofluorescein as an indicator.


Medical treatment of chronic hypertension.


The influence of genetical and environmental factors on the prevalence of rheumatoid arthritis and rheumatoid factor.


Studies on young germ-free mice. I. Stress reaction of germ-free mice.


Brain monoamines and endocrine function.


Effect of tilorone hydrochloride on the experimental rabies of mice.


Regional distribution of brain catecholamines and serotonin.


Granular vesicles as criteria for intracellular localization of monoamines.


Monoamines and the control of gonadotropin secretion.


Pituitary-gonad function and brain norepinephrine.


Analysis of norepinephrine metabolism in nonsteady states.


Brain lesion effects on monoamine metabolism and on pituitary function.


Joint effects of lesions on monoamines and endocrine function.


A comprehensive adolescent maternity program in a community hospital.


Adenocarcinoma of the endometrium. Twenty-five years' experience in private practice.


Biochemical-biophysical basis of shock.

Biochemical-biophysical basis of shock.


Changing maternal and child health in Uganda.


Clinicopathological study on experimental Trypanosma brucei infections in horses. 2. Histopathological findings in the nervous system and other organs of treated and untreated horses reacting to nagana.


Acylation of carcinogenic aromatic hydroxamic acids by acetyl-CoA and carbamoyl phosphate to form reactive esters.


Clinicopathological study on experimental Trypanosoma brucei infections in horses. 1. Development of clinically recognizable nervous symptoms in nagana-infected horses treated with subcurative doses of Antrypol and Berenil.


Determination of arsenic in coal and in insecticides by atomic absorption spectroscopy.


Aromatic amine carcinogenesis: the importance of N-hydroxylation.


Elective hysterectomy.

Elective hysterectomy.


Biodegradations of the hydroxamic acid group of p-n-butoxyphenylacethydroxamic acid (bufexamac) in various animal species.


Fate of endotoxin in the circulation.

Fate of endotoxin in the circulation.


Fluorescence properties of the Zimmermann chromogen: paper chromatography of ketosteroids.


Comparative C- and N-oxidation of (plus)- and (minus)-nicotine by various species.


How preventable is invasive cervical cancer? A community study of preventable factors.


Hypertension and oral contraception.

Hypertension and oral contraception.


Introduction: an overview of the shock problem.


Laboratory investigations on the life-cycle of the Karoo paralysis tick (Ixodes rubicundus Neumann, 1904).


Deuterium isotope effects and stereochemistry in the dealkylation and deamination of amphetamines and ephedrines in man.


Laminaria tent: relic of the past or modern medical device?


Comparison of the in vitro and in vivo N-oxidation of the carcinogenic aromatic amines.


Liver metabolism and energy production in Staphylococcus aureus septic shock in mice.


Low cost TV display system.

Low cost TV display system.


Hepatic mixed function amine oxidase. An allosteric system.


Myocardial metabolism during acute hemorrhagic or endotoxic shock.


Nasal acariasis in the chacma baboon, Papio ursinus Kerr, 1792.


Ovulation following therapeutic abortion.


Hydroxylation of the acetamide moiety of N-arylacetamides in rabbits.


Oxyhemoglobin dissociation curve in hemorrhagic and septic shock.


Physiologic mechanisms in clinical shock.


Platelet, hemodynamic, and respiratory changes in shock, sepsis, and trauma.


Postpartum ovarian vein thrombophlebitis. A report on four cases.


Pregnancy following radical operation for rectal carcinoma.


Proliferation and differentiation in the neural tube of the chick following limb bud or somite removal.


Proposed reclassification of shock states with special reference to distributive defects.


N-oxides of the oxindole alkaloids rhynchophylline and isorhynchophylline.


Pulmonary dysfunction after shock and trauma.


Pulmonary dysfunction in shock.

Pulmonary dysfunction in shock.


Metabolic oxidation of aliphatic basic nitrogen atoms and their alpha-carbon atoms.


Radical vaginal hysterectomy: its role in the treatment of cancer of the cervix.


Role of leukocytes in the lung after endotoxin administration.


Release of toxic agents in septic shock.


Oxidative metabolism of tertiary amine drugs by human liver tissue.


Rupture of the spleen. A review and report of a case following abdominal hysterectomy.


Stationary platinum electrode for measurement of o2 exchange by biological systems under hydrostatic pressure.


Studies concerning a radioimmunoassay for oxytocin.


Studies on South African cardiac glycosides. I. Isolation of toxic principles of Homeria glauca (W. & E.) N.E. Br. and observations on their chemical and pharmacological properties.


Synthesis of high-molecular-weight RNA in Xenopus ectoderm after neural induction.


The follow-up of 141 cases of untreated invasive cervical carcinoma.


Some observations on the type I and type II microsomal binding spectra.


The mechanism of the "lung lesion" in shock.


The relationship between oxygen uptake and a toxic factor in septic shock.


Tryptic activation of Clostridium botulinum type C beta toxin.


Vascular lesions in endotoxemia.

Vascular lesions in endotoxemia.


What mechanisms influence oxygen transport and oxygen tissue delivery in endotoxic and hemorrhagic shock?


Involvement of catecholamines and indolamines in the control of pituitary gonadotropin release.


The in vitro metabolism of (35S)chlorpromazine.


The metabolism of repeatedly administered trans-4-dimethylaminostilbene and 4-dimethylaminobibenzyl.


Quantitative histochemistry of rat supraoptic nucleus.


The metabolism of i-diethylcarbamyl-4-methylpiperazine in the rat and the sheep.


Regulation of the reproductive system by the pineal gland and its dependence on light.


The influence of the pineal body on the gonadotropic function of the hypophysis.


Identity of hypothalamic feeding mechanisms.


Impotence in temporal lobe lesions.

Impotence in temporal lobe lesions.


Time sequence of liver phospholipid alterations during deprivation of dietary choline.


Regulation of ovarian cholesterol esters: evidence for the enzymatic sites of prostaglandin-induced loss of corpus luteum function.


Serum phospholipids in diabetic patients with late manifestations.


Lipoprotein and lipid composition of neonatal serum.


The course of the analysis of a narcissistic personality with hysterical and compulsive features.


Spasmodic torticollis: a psychogenic condition?


The Saskatoon Smoking Study. Results of the first year.


The lens and glaucoma. Cryoextraction of cataract.


Seasonal variations of bacterial flora of the conjunctival sac and their relation to infection of intra-ocular operations.


Sarcoidosis of the lacrimal gland. Clinicopathological reports of two cases with successful deep X-ray therapy.


Superficial punctate keratitis.

Superficial punctate keratitis.


Juvenile ankylosing spondylitis. Report of three cases.


The psychoneurological dysfunction child. (Special education center versus special class within the regular school).


Medical experience in nuclear submarines.


Diallel analysis of avoidance conditioning in inbred strains of mice.


Reprise: the coalition of independent health professions.


Synergy of carbenicillin and gentamicin in experimental infection with Pseudomonas.


A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. A computer model of the metabolism of glutamate, glutamine, gamma-aminobutyrate, and the tricarboxylic acid cycle in mouse brain has been constructed in terms of 39 reactions among 19 substances or groups of substances (permitting manipulation of 30 independent variables). The model is divided into two compartments, in conformity with previous models based on indirect evidence, and it is found that this compartmentation is indeed the same as that indicated directly with specifically (14)C-labelled acetate and glucose. The movement of materials between the large and small compartments has been studied; glutamine appears to flow from the small to the large compartment, gamma-aminobutyrate in the reverse direction.


The current uses of coronary angiography.


Pesticide residue levels in foods in the United States from July 1, 1963 to June 30, 1969.


The effects of retinal orientation on word recognition.


Operant conditioning and self-control of smoking and studying.


The structure and vascularization of the skin and of the gills in the river lamprey (Lampetra fluviatilis L.).


Bovine viral diarrhea-mucosal disease virus infection in pregnant cows.


Myenteric ganglial cells in dogs with and without hereditary achalasia of the esophagus.


Effect of ambient temperature on gastric lesions and gastric secretion in swine.


Enzootic pneumonia in rabbits: naturally occurring lesions in lungs of apparently healthy young rabbits.


Identification of crystalline material in urine of rabbits.


Pineal body of the northern fur seal (Callorhinus ursinus): a model for studying the probable function of the mammalian pineal body.


The serodiagnosis of paratuberculosis.

The serodiagnosis of paratuberculosis.


Preweaning weight as a measure of milk production in mice.


Dimensional and architectural disproportion between the intrauterine device and the uterine cavity. A casue of bleeding. Hysterograms were performed on 172 women fitted with 30 mm Lippes Loops to determine uterine dimensions.  Uteri classifications were: normal; triangular, divided into 1) small triangle, 30 mm. loop was too large; 2) medium triangle, device fits snugly, less severe bleeding at 7 months; 3) large triangle, device too small, mild bleeding at 10  months and formal conical cavity, divided into 1) narrow fundus, too small for device, leading to traumatic bleeding; 2) medium, device fits snugly causes intermenstrual bleeding; 3) large, loop covers only a portion of uterine cavity,  bleeding less severe later.  Ideally the IUD should fit snugly against the various borders of the uterine cavity, exerting light and equal pressure.  Congenital anomalies and devices incorrectly positioned caused intermenstrual bleeding.


The effect of fixation on the chemical extraction of glycogen from rat liver.


Subcellular distributions and properties of rat testicular acid phosphatases.


Rabies in Maine, 1971.

Rabies in Maine, 1971.


[Studies on cardiovascular drugs. I. Increasing effect of benzodioxane derivatives on blood flow of anesthetized dogs].


What's your diagnosis?

What's your diagnosis?


Inhibition of DNA synthesis but not of poly-dAT synthesis by the arabinose analogue of cytidine in vitro.


Sensory neglect produced by lateral hypothalamic damage. Unilateral lateral hypothalamlic lesions in rats produce deficits in orientation to contralateral visucal, olfactory, whisker-toluch, and somatosetnsory stimuli. This syndrome of sensory neglect appears to be involved in some of the deficits in feedinig and attack which follow bilateral lateral hypothalamic lesions.


Influence of ribonucleic acid from inflammatory leukocytes on the uptake of C14 glycine into protein by bone marrow and thymus cells.


Feeding problems and preschool intelligence scores: a study using the co-twin method.


Leukemia and multiple myeloma in farmers.


African histoplasmosis due to Histoplasma duboisii.


Nutrient intake of Pima Indian women: relationships to diabetes mellitus and gallbladder disease.


A study of the reproductive tracts of female water buffaloes in Iraq.


Further investigations on the use of irradiated eggs to develop immunity against Ascaridia galli in chickens.


A complement fixation test for tick-borne fever of sheep.


The doctor and sex education.

The doctor and sex education.


INsects parasitic on the saw-whet owl, Aegolius acadicus (Gmelin) (Aves: Strigidae).


Epidemiology of cancer of the colon and rectum.


Congenital heart disease--clinical features and pathophysiology.


Pharmacy-veterinary medicine relations.

Pharmacy-veterinary medicine relations.


Rabies in raccoons in the Southeastern United States.


An epizootic of A2/Hong Kong/68 influenza in gibbons.


Roentgenographic presentation of aberrant pancreas in the gastric antrum.


Repeatability estimates and quantification of uterovaginal sperm-host gland numbers and population patterns.


Release of LH by estradiol in cycling ewes.


Second annual Carl G. Hartman Lecture. Experimental studies of mammalian spermatozoa and eggs.


The role of the ovary in control of cyclic LH release in the hamster, Mesocricetus auratus.


The circular dichroism in the ultraviolet of aminoacridines and ethidium bromide bound to DNA.


Bovine serum albumin (BSA)-calcium binding studies with a calcium selective liquid membrane electrode. Preliminary report.


47 CA turnover of a readily exchangeable calcium pool in pregnant and lactating cows.


Genetics of somatic mammalian cells. XII. Mutagenesis by carcinogenic nitroso compounds.


Modification of cell surface antigenicity as a function of culture conditions.


Cytotoxic effects of thiopyrimidines.

Cytotoxic effects of thiopyrimidines.


The 5-methylcytosine content of DNA: tissue specificity.


Cytoplasmic synthesis of an arginine-rich nuclear component during infection with an influenza virus. A component relatively rich in arginine which was induced by infection with an influenza virus was synthesized in the cytoplasm of the infected cell and migrated to the nucleus. This conclusion was drawn from the grain distribution in autoradiograms and the displacement of (3)H-arginine in isolated cytoplasmic and nuclear fractions after a short pulse and subsequent chase.


Deoxyribonucleic acid polymerase activity associated with strain MC29 tumor virus. Chick embryo cells infected with strain MC29 tumor virus yielded progeny virus that contained detectable deoxyribonucleic acid (DNA) polymerase within the first 48 hr after infection. The noninfected culture fluids displayed no such enzyme activity when examined in an identical manner. Enzyme activity was greatly stimulated by adding DNA template to the reaction mixture and required all four deoxyribonucleoside triphosphates for full activity. When calf thymus DNA was used to direct synthesis, the DNA polymerase from the MC29 virus catalyzed the formation of DNA product having a higher buoyant density in CsCl. DNA product formed in the reaction directed by Micrococcus lysodeikticus DNA had the same buoyant density as the template DNA.


Structural proteins of rabies virus.

Structural proteins of rabies virus. Purified rabies virions, unlabeled or labeled with radioactive amino acids or d-glucosamine, were dissociated into their polypeptides by treatment with sodium dodecyl sulfate in a reducing environment and fractionated by electroiphoresis in sodium dodecyl sulfate-containing polyacrylamide gel. The molecular weights of individual polypeptides were estimated by comparison of their rate of migration with that of protein markers of known molecular weight. Purified viral nucleocapsid and a mixture of envelope components, isolated from virions disrupted by sodium deoxycholate, were analyzed by the same procedure. The number of molecules per virion of each polypeptide was estimated from the proportions of the separated components, the known molecular weight of the viral ribonucleic acid, and the chemical composition of the nucleocapsid. The protein moiety of the nucleocapsid particle was estimated to consist of 1,713 molecules of a major polypeptide (molecular weight, 62,000 daltons) and 76 molecules of a minor polypeptide (molecular weight, 55,000 daltons). In addition to 1,783 molecules of a glycoprotein component (molecular weight, 80,000 daltons), the viral envelope contains 789 and 1,661 molecules, respectively, of two other polypeptides (molecular weight, 40,000 and 25,000 daltons).


Tongue rolling among twins.

Tongue rolling among twins.


Role of magnesium in effects of epinephrine on heart contraction and metabolism.


Effect of antibiotics on staphylococcal hemolysin production. Thirty-seven per cent of 126 strains of Staphylococcus aureus, when tested on sheep blood-agar with sensitivity discs containing cephalothin, carbenicillin, oxacillin, penicillin, and cycloserine, produced rings of beta-hemolysis surrounding zones of inhibition of bacterial growth. Each strain capable of producing a ring of beta-hemolysis did so with at least two of the mentioned antibiotics. None of the other 15 antibiotics tested was associated with a ring of beta-hemolysis surrounding any of the zones of inhibition. It appears, therefore, that the beta-hemolysis observed was produced by certain strains of S. aureus only in association with certain antibiotics.


Rapid detection of viral antibody by cellulose acetate electrophoresis. An immunoelectrophoretic procedure utilizing microprecipitation and cellulose acetate electrophoresis was developed for detection of antibody to specific virus. A model system of tobacco mosaic virus and homologous rabbit antiserum is described.


Antibiotic synthesis and morphological differentiation of Cephalosporium acremonium. In submerged cultures, Cephalosporium acremonium exists in four morphological forms: hyphae, arthrospores, conidia, and germlings. The phase of hyphal differentiation into arthrospores coincides with the maximum rate of beta-lactam antibiotic synthesis. Furthermore, arthrospores, separated by density-gradient centrifugation, possess 40% greater antibiotic-producing activity than any other morphological cell type. In a series of mutants, each with an increased potential to produce beta-lactam antibiotics, differentiation into arthrospores was proportional to the increased titer of these antibiotics. Thus, arthrospores exhibit enhanced synthesis of beta-lactam antibiotics and appear to be a determining factor in high-yielding mutants. Since a non-antibiotic-producing mutant readily differentiated into arthrospores, antibiotic synthesis and cellular differentiation are not obligately related.


Heterokaryosis in the entomogenous fungus, Metarrhizium anisopliae.


In vitro sensitivity of Torulopsis glabrata to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097). Thirty-five strains of Torulopsis glabrata were tested by a tube dilution method for their susceptibility to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097). Amphotericin B was the most active in vitro, inhibiting all strains at a concentration of 1 mug/ml and killing all strains at 2 mug/ml. 5-Fluorocytosine inhibited over 80% of strains at 0.24 mug/ml, but three strains required >/=7.8 mug/ml for killing. A concentration of 2 mug of clotrimazole per ml inhibited less than 50% of strains, and 8 mug/ml killed only 10% of strains. Most strains of T. glabrata were killed by therapeutically achievable concentrations of amphotericin B and 5-fluorocytosine, but not clotrimazole.


Microbial epoxidation of cis-propenylphosphonic to (-)-cis-1,2-epoxypropylphosphonic acid. Eighteen species of Penicillium, one of Oidium and one of Paecilomyces were found to effect a stereospecific conversion of cis-propenylphosphonate to fosfomycin which was identified by paper chromatography and gas-liquid chromatography (GLC) of the trimethylsilyl esters. Penicillium spinulosum carried out the epoxidation only after the glucose substrate had been utilized. Glucose controlled the epoxidation since its residual concentrations in the broth severely depresses the reaction. At optimum levels of glucose, an epoxidation efficiency approaching 90% of olefin charged (0.2 g/liter) was obtained after 10 days of incubation. The olefin concentration could be increased to 0.5 g/liter when glucose was replaced by glycerol, whereby a 90% conversion to fosfomycin was attainable in 6 days. The high conversion efficiency, a good agreement between the GLC assay and bioactivity, are indicative of the levorotatory nature of the product.


Further observations on Dipetalonema perstans.


Biosynthesis of lysine in Rhodotorula: accumulation of homocitric, homoaconitic, and homoisocitric acids in a leaky mutant.


Haploid cells in rat kangaroo corneal endothelium cultures and x-ray-induced chromosome aberrations.


Quantitative studies on the mixed lymphocyte interaction in rats. V. Tempo and specificity of the proliferative response and the number of reactive cells from immunized donors. These studies were designed to determine what influence prior immunization with homologous H isoantigens might have on the subsequent proliferative activity of lymphocytes from these animals in the mixed lymphocyte interaction. The results demonstrate the following: (a) Subcutaneous immunization with splenic cells from donors differing at the major H locus accelerates the tempo of the proliferative response to F(1) cells bearing these same antigens in the MLI, whereas antigen given systemically reduces the proliferative response. (b) The altered proliferative behavior is specific for the immunizing antigens. (c) The period after immunization during which the MLI displays an altered tempo is a short one, lasting not longer than 3 wk. (d) Whether they are derived from previously immunized or from normal donors, the proportion of lymphocytes responsive in the MLI is the same, even though the response profiles are different. These results suggest that in comparison to immune responses to other types of antigens, immunologic reactivity to the major H isoantigens already involves a large number of antigen-reactive cells in normal animals and that the proportion of these cells is not increased as a result of immunization. Rather, lymphocytes from immunized animals respond more rapidly to the presence of these antigens.


Participation of three cell types in the anti-sheep red blood cell response in vitro. Separation of antigen-reactive cells from the precursors of antibody-forming cells. Spleen cells of unprimed CBA mice were shown to produce anti-sheep red blood cell antibodies comparable in amount in vivo and in vitro. Under identical culture conditions spleen cells of C57BL mice did not respond. CBA spleen cells, passed through columns of cotton wool (CBAf), were equally inactive in vitro. However combined cultures containing both CBAf and C57BL cells yielded as many or more plaque-forming cells than the same number of unfractionated CBA spleen cells. Analysis of the contribution of each cell population to the synthesis of antibody in the combined cultures has disclosed the participation of three cell types. A thymus-dependent, radiosensitive cell was derived from the CBAf population, while the C57BL was the source of the precursor of the antibody-forming cell and of a radioresistant cell. The latter two were partially separated in a Staput apparatus.


The formation and nature of foci induced by a modified sarcoma virus in human cells.


An unusual membrane organization observed during spermiogenesis in the mite Caloglyphus anomalus.


Treatment of the double cleft of the primary and secondary palate with a protruding premaxilla.


Differences in radiosensitivity of the chromosomes of rat kangaroo (Potorous tridactylis) cells in vitro.


The response of Chinese hamster cells to N-methyl-N'-nitro-N-nitrosoguanidine.


Measurement of the glomerular filtration pressure from sieving data for macromolecules.


Analysis of the isovolumic pressure in the canine left ventricle.


Changes in the interstitial pH of dog myocardium in response to local ischemia, hypoxia, hyper- and hypocapnia, measured continuously by means of glass microelectrodes.


Fungi isolated from keratomycosis in Ontario, Canada. I. Monosporium apiospermum (Allercheria boydii).


Immunochemical studies on Trichophyton mentagrophytes.


Diagnosis and treatment of aspergillosis in captive cormorants.


Isolation of Microsporum cookei from a human case.


Kasabach-Merritt syndrome: coagulo--analytical observations.


A dietary regimen in the treatment of psoriasis.


Quantitative under-feeding of Drosophila: effects on adult longevity and fecundity.


Insulin peptides. XXI. A synthesis of the B chain of sheep (bovine, porcine) insulin and its isolation as the S-sulfonated derivative.


The treatment of cerebral ischemia with hyperbaric oxygen (OHP).


Heritability of adaptive variation.

Heritability of adaptive variation.


The oilseed industry of India--potential for food use of proteins.


Number and size of nucleoli in binucleate liver cells.


Axo-axonic septate junctions in the basket formations of the cat cerebellar cortex.


Potential danger of Q fever in a university hospital environment.


"Chronic infectious arthritis"--role of mycoplasmas.


Surveillance for Salmonella-1969.

Surveillance for Salmonella-1969.


Studies on Alternaria blight of wheat in Madhya Pradesh.


Metarrhizium anisopliae (Metchinkoff) Sorokin., and its host range.


Toxicity of catechol to Alternaria spp.

Toxicity of catechol to Alternaria spp.


Quantitative trial of free amino acid concentrations in the mouse brain loci by gas-liquid chromatography.


Retention of 1-44 micron simulated fallout particles by soybean and sorghum plants.


Identical twins with marked weight dissimilarity.


In vivo requirement for a radiation-resistant cells in the immune response to sheep erythrocytes. Experiments have been done to establish whether the radiation-resistant or A cell has a specific function in the initiation of an immune response in mice to sheep erythrocytes (SRBC). All previous demonstrations using accessory (A) cells have involved in vitro assays and are possibly explainable as tissue culture artifacts. If A cells are essential, it should be possible to demonstrate their requirement in vivo. Therefore we first established such conditions. Two methods were found for creating an A-cell deficiency in vivo: (a) A cells disappear gradually from the spleens of irradiated mice, presumably by migration since A-cell function was shown not to be decreased by irradiation. If 3 days elapse between irradiation and transplantation of mixtures of bone marrow and thymus cells (which provide B and T but few A cells), the usual synergistic response does not occur. Addition of large numbers of freshly irradiated spleen cells to the mixture of bone marrow and thymus completely restores the immune response. (b) Injection of 10(10) horse erythrocytes into mice suppresses A-cell activity in these mice 24 hr later; a much reduced response to SRBC is obtained when they are given at this time. The response can be partially restored if irradiated spleen cells are given with the SRBC. This observation formed the basis for a quantitative in vivo assay for A cells in which the magnitude of restoration by various suspensions of irradiated cells was used to estimate the A-cell activity of that suspension. A quantitative in vitro assay for A cells was also developed. It was essential for this assay that the total cell number, B-cell number, and T-cell number be kept constant and that only the number of A cells be allowed to vary. Only under these conditions was the response a linear function of the number of A cells added. If the in vivo and in vitro assays are detecting the same class of radiation-resistant cells, the physical properties of the cells active in each assay should be identical. Spleen cells were separated on the basis of both density and sedimentation velocity. Fractions from both separation methods were tested for their content of A cells using both the in vivo and in vitro assays. The density and sedimentation profiles of A cells were similar in both assays. The demonstration that a radiation-resistant cell is required in vivo and that this cell has properties identical to the radiation-resistant cell required in vitro indicates that this cell (the A cell) is directly involved in the initiation of an immune response to erythrocyte antigens.


Cell-to-cell interaction in the immune response. VII. Requirement for differentiation of thymus-derived cells. Experiments were designed to test the possibility that thymus-derived (T) cells cooperate with nonthymus derived (B) cells in antibody responses by acting as passive carriers of antigen. Thoracic duct lymphocytes (TDL) from fowl gammaG-tolerant mice were incubated in vitro with fowl anti-mouse lymphocyte globulin (FALG), which was shown not to be immunosuppressive in mice. On transfer into adult thymectomized, irradiated, and marrow protected (TxBM) hosts together with a control antigen, horse RBC, a response to horse RBC but not to fowl gammaG was obtained. By contrast, TxBM recipients of nontolerant, FALG-coated TDL responded to both antigens and the antibody-forming cells were shown to be derived from the host, not from the injected TDL. These findings suggested that, under the conditions of the experiment, triggering of unprimed B cells in the spleens of TxBM hosts was not achieved with antigen-coated tolerant lymphocytes. Another model utilized the ability of B cells to bind antibody-antigen complexes. Spleen cells from TxBM mice, incubated in vitro with anti-fowl gammaG-fowl gammaG.NIP, were injected with or without normal TDL (a source of T cells) into irradiated hosts. Only mice given both cell types could produce an anti-NIP antibody response. In a further experiment, spleen cells from HGG.NIP-primed mice were injected together with NIP-coated B cells (prepared as above) into irradiated hosts. A substantial anti-NIP antibody response occurred. If, however, the T cells in the spleens of HGG.NIP-primed mice were eliminated by treatment with anti-theta serum and complement, the NIP response was abolished. It was concluded that antigen-coated B cells could not substitute for T cells either in the primary or secondary response. Treatment of T cells from unprimed or primed mice with mitomycin C impaired their capacity to collaborate with B cells on transfer into irradiated hosts. Taken together these findings suggest that before collaboration can take place T cells must be activated by antigen to differentiate and in so doing may produce some factor essential for triggering of B cells.


Analysis of arbovirus ribonucleic acid forms by polyacrylamide gel electrophoresis. Viral ribonucleic acid (RNA) from Semliki Forest virus- and Sindbis virus-infected cells was analyzed by electrophoresis on polyacrylamide gels. In contrast to earlier results obtained by sucrose density gradient centrifugation, all of the known viral RNA forms (i.e., the 42S, 26S, replicative form, and replicative intermediate) were very clearly separated. The high resolution of the electrophoretic method permitted the identification of two new single-stranded RNA species. In addition, the replicative form was shown to be heterogeneous and to consist of at least two forms. The results suggested that the replicative forms occur in vivo although in relatively small amounts.


Irish hospitals: lion's share of funding comes from horses.


Selective impairment of Pavlovian conditional responses by electroconvulsive shock.


Effects of neonatal castration and testosterone on the rat's pup-killing behavior and activity.


Retrograde amnesia and brain seizures in mice.


Time-dependent memory deficits produced by pentylene-tetrazol (Metrazol)--the effect of reinforcement magnitude.


Studies on the size and shape of eggs of Schistosoma japonicum at Khong Island, southern Laos.


Maduromycosis (maduromycotic mycetoma) in the Philippines caused by Madurella grisea.


Intestinal parasitism in residents of the Mekong delta of Vietnam.


Venomous snakes of Southeast Asia.

Venomous snakes of Southeast Asia.


A preliminary report on the life cycle of Stephanofilaria kaeli.


Blood parasites of domestic fowl in Malaysia.


Spirocercosis in dogs in Kuala Lumpur.

Spirocercosis in dogs in Kuala Lumpur.


Studies on human platelets. IV. Protein synthesis in maturing human platelets.


Development and mechanisms of cardiorespiratory responses to maternal deprivation in rat pups.


Biochemical studies on adenovirus multiplication. 18. Resolution of early virus-specific RNA species in Ad 2 infected and transformed cells.


Proteins of polyhedral cytoplasmic deoxyviruses. I. The structural polypeptides of FV 3 .


Expression of concanavalin A binding sites in rabbit kidney cells infected with vaccinia virus.


Separation of two polypeptide chains from the hemagglutinin subunit of influenza virus.


Synthesis of proteins in cells infected with herpesvirus. VII. Lack of migration of structural viral proteins to the nucleus of arginine-deprived cells.


Purification of a nucleoside diphosphate kinase from pea seed and phosphorylation of the enzyme with adenosine ( 32 P) triphosphate.


Penetration of the uterine epithelium during implantation in the rabbit.


Cytoplasmic filaments in developing and adult vertebrate smooth muscle. An extensive study of adult and developing smooth muscle has revealed the widespread occurrence of a distinct filament with an average diameter of about 100 A (termed the 100 A filament). Unlike that of myofilaments, their appearance in longitudinal section is uniform, but in transverse section they have a round profile, occasionally exhibiting a less electron-opaque core. The 100 A filaments are almost invariably preserved under a variety of fixation procedures, whereas myofilaments, particularly the thicker filaments, are preserved inconsistently. The 100 A filaments appear to be randomly oriented throughout the cytoplasm, either singly or in small groups, although they are sometimes concentrated in the juxtanuclear region of the smooth muscle cells. The intimate association of 100 A filaments with dark bodies, in both developing and adult smooth muscle cells, may indicate that these filaments either play a role in dark body formation or, at least, constitute a part of the dark body. The 100 A filaments are conspicuous in developing smooth muscle cells and occasionally form networks or clusters; they appear to decrease in relative number as maturation proceeds, but considerable numbers are still present in adult tissue.


Synthesis and storage of microtubule proteins by sea urchin embryos. Studies employing colchicine binding, precipitation with vinblastine sulfate, and acrylamide gel electrophoresis confirm earlier proposals that Arbacia punctulata and Lytechinus pictus eggs and embryos contain a store of microtubule proteins. Treatment of 150,000 g supernatants from sea urchin homogenates with vinblastine sulfate precipitates about 5% of the total soluble protein, and 75% of the colchicine-binding activity. Electrophoretic examination of the precipitate reveals two very prominent bands. These have migration rates identical to those of the A and B microtubule proteins of cilia. These proteins can be made radioactive at the 16 cell stage and at hatching by pulse labeling with tritiated amino acids. By labeling for 1 hr with leucine-(3)H in early cleavage, then culturing embryos in the presence of unlabeled leucine, removal of newly synthesized microtubule proteins from the soluble pool can be demonstrated. Incorporation of labeled amino acids into microtubule proteins is not affected by culturing embryos continuously in 20 microg/ml of actinomycin D. Microtubule proteins appear, therefore, to be synthesized on "maternal" messenger RNA. This provides the first protein encoded by stored or "masked" mRNA in sea urchin embryos to be identified.


Formation and distribution of nuclear pore complexes in interphase. The possibility of nuclear pore formation in the interphase nucleus was investigated in control and phytohemagglutinin (PHA) stimulated lymphocytes by the freeze-etching technique. 48 hr after the addition of PHA, the newly formed blasts which had not as yet divided had at least twice the number of pores per nucleus as controls. This clearly demonstrates that in lymphocytes nuclear pore formation can take place during interphase. It has generally been assumed that the distribution of nuclear pore complexes in somatic animal cells is random. However, we have utilized freeze etched rat kidney cells and a computer program to evaluate pore distribution. We find a minimum pore center-to-center spacing of approximately 1300 A and multiples thereof with high frequency. This is strong evidence for a nonrandom distribution of nuclear pores. The nonrandomness may be related to an underlying chromosomal organization in interphase. Using three criteria for identifying prospective pore sites (membrane specialization, nonrandomness, and alteration of heterochromatin distribution), we have found forming pores in sectioned material from cultured human melanoma cells. While nuclear pore formation may take place in conjunction with reformation of the nuclear membrane, a mechanism also exists for their formation during interphase.


Evidence for cell-surface glycosyltransferases. Their potential role in cellular recognition. Intact chicken embryo neural retina cells have been shown to catalyze the transfer of galactose-(14)C from uridine diphosphate galactose (UDP-galactose) to endogenous acceptors of high molecular weight as well as to exogenous acceptors. Four lines of evidence indicate that the galactosyltransferases catalyzing these reactions are at least partly located on the outside surface of the plasma membrane: (a) there is no evidence for appreciable uptake of sugar-nucleotides by vertebrate cells nor did unlabeled galactose, galactose 1-phosphate, or UDP-glucose interfere with the radioactivity incorporated during the reaction; (b) the cells remained essentially intact during the course of the reaction; (c) there was insufficient galactosyltransferase activity in the cell supernatants to account for the incorporation of galactose-(14)C into cell pellets; and (d) the intact cells could transfer galactose to acceptors of 10(6) daltons, and the product of this reaction was in the extracellular fluid. Appropriate galactosyl acceptors interfered with the adhesive specificity of neural retina cells; other compounds, which were not acceptors, had no effect. These results suggested that the transferase-acceptor complex may play a role in cellular recognition.


[Changes in the activity of amylase caused by heating].


Notes of a biology-watcher. The music of this sphere.


Glutamic acid decarboxylase in Parkinson's disease and epilepsy.


Fibrinolytic activity in venous blood of patients with muscular dystrophy.


Reversal of the reserpine syndrome with L-dopa metabolites in reserpinized rats.


When is multiple sclerosis acquired?

When is multiple sclerosis acquired?


An evaluation of the cerebrospinal fluid infusion test for hydrocephalus.


Arteriovenous malformation of the vein of Galen as a cause of heart failure and hydrocephalus in infants.


Citrate and alpha-ketoglutarate in cerebrospinal fluid and blood.


Spinal epidural hematoma and the Brown-Séquard syndrome.


Pseudoperiodic lateralized paroxysmal discharges in electroencephalogram.


Carotid hemodynamics and the ocular pulse in carotid stenosis.


The neurologist and the physically abused child.


Developmental defects of the kidney. A review of renal development and experimental studies of maldevelopment.


Amputation in children. A follow-up of 74 children whose lower extremities were amputated.


Experimental studies of essential hemospermia with special reference to the fibrinolytic activity.


Our priceless possession.

Our priceless possession.


Marijuana and health: a report to the Congress.


Characteristics of Venezuelan equine encephalomyelitis virus ribonucleoprotein.


Effects of electrical stimulation of the cingulate gyrus upon attack behavior elicited from the hypothalamus in the cat.


Effect of genital stimulation on the brain stem multi-unit activity of anestrous and estrous cats.


Behavior therapy.

Behavior therapy.


Telephone therapy.

Telephone therapy.


Multiple affinities for binding of cholinergic ligands to a particulate fraction of Torpedo electroplax.


Schizokinesis: fragmentation of performance in two strains of pointer dogs.


Collimating system for electron beams.

Collimating system for electron beams.


Curvularia endocarditis following cardiac surgery.


Morphology and histology of the teleostean intestine.


Comparative studies on the hydrolysis of odd-chain and even-chain fatty acid cholesterol esters by rat liver sterol ester hydrolase.


Seal milk. II. Harp seal (Pagophilus groenlandicus) milk: effects of stage of lactation on the composition of the milk.


The nymphs of the nemouridae of Eastern Canada (Insecta: Plecoptera).


Axenic production of ova by Enchytraeus fragmentosus (Bell).


Aggressive behavior of Apis mellifera L. workers towards introduced queens. II. Role of the mandibular gland contents of the queen in releasing aggressive behavior.


Wildlife foci of Capillaria hepatica infections in Manitoba.


Why early diagnosis.

Why early diagnosis.


Pattern of anemias in childhood.

Pattern of anemias in childhood.


Characterization of the A component of Streptococcus zymogenes lysin. By utilizing conventional techniques of pressure ultrafiltration, gel filtration chromatography, diethylaminoethyl cellulose chromatography, and preparative polyacrylamide electrophoresis, the A component of the group D lysin produced by Streptococcus zymogenes has been purified to a state of apparent homogeneity when determined by the techniques of anionic and cationic disc gel electrophoresis. The A component was found to be a protein possessing a molecular weight of 27,000, a sedimentation coefficient approximating 3.2S, and a net negative charge at physiological pH.


Naphthyridines. 3. Preparation of pyrimido[1,2-a]-and imidazo-[1,2-a]-[1,8]naphthyridines from 2-amino-1,8-naphthyridines.


Naphthyridines. IV. Preparation of anthyridines and pyrimido-[4,5-beta][1,8]naphthyridines from 2-amino-1,8-naphthyridines.


2,3-Dihydro-3,6-dihydroxy-2-methyl-4-pyrone and curvularin from Penicillium gilmanii.


The gentamicin antibiotics. 3. The gross structures of the gentamicin C components.


Polluted water--a challenge to forensic biology.


Psychological and physiological origins of racism and other social discrimination.


Personal space, anger-arousal, and psychological defense.


Do dogs laugh? A cross-cultural approach to body symbolism.


Inhibition of macrophage migration.

Inhibition of macrophage migration.


Legislative harassment of physicians and researchers.


Pig liver perfusion in the treatment of fulminant hepatic necrosis.


N-substituted analogues of neuroleptics of the octoclothepin series: relations between structure and activity.


Pharmacological properties of a new potential neuroleptic drug oxyprothepin. I. The action on the central nervous system in rodents.


Pharmacotherapy in the premenstrual tension.


Antialcohol effects of some ethanolamine derivatives.


Behaviour of untreated mice to alcohol- or chlordiazepoxide-treated partners.


Effect of palmitoyl ethanolamide on the central nervous system.


The effect of chlorprothixene and caffeine on the conditioned alimentary motor reflexes in cats.


The effect of reserpine and nortriptyline on the excretion of 17-hydroxysteroids.


The human heart at seven postovulatory weeks.


Erythrocyte levels of 2,3-diphosphoglycerate in the syndrome of fetal malnutrition.


Continuous lumbar peridural anesthesia in obstetrics. VII. Distribution of local anesthetic agents in maternal and fetal blood.


Controlled comparison of amitriptyline and meperidine as preanesthetic treatment.


Comparison of automated Doppler ultrasound and Korotkoff measurements of blood pressure of children.


Fetal and maternal effects of bicarbonate administration during labor.


Thoughts about medical writing. VII. Papa, the model.


The correlation between the saturation of membrane fatty acids and the presence of membrane fracture faces after osmium fixation.


Apparatus: an improved automatic laryngoscope spray.


On the mechanism of non-electrolyte permeation through lipid bilayers and through biomembranes.


Computer analysis of respiratory data.

Computer analysis of respiratory data.


Effect of nitrous oxide on the pulmonary circulation during venous air embolism.


Adrenocortical function related to thiopental-nitrous oxide-oxygen anesthesia and surgery in man.


The binding of benzyl alcohol to erythrocyte membranes.


Use of saline injections into the trachea to help mobilize aspirated material for removal by suctioning.


An incident of cylinder retaining screws damaging the Woods metal in the temperature safety screw of a cyclopropane cylinder valve.


Monolayer characteristics and calcium adsorption to cerebroside and cerebroside sulphate oriented at the air-water interface.


Effects of Innovar and innovar plus nitrous oxide on muscle tone and "H" reflex.


Phospholipid-protein interactions: membrane permeability correlated with monolayer "penetration".


BI-ionic potentials of bovine lens capsules and collodion membranes.


Correctable complications of neoplastic disease. 3. Neoplastic effusions.


Preparation of immunologically responsive liposomes with phosphonyl and phosphinyl analogs of lecithin.


An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border.


Penetration of local anesthetics through epithelial barriers.


Cytochalasin effects on BALB-3T3 fibroblasts: dose-dependent, reversible alteration of motility and cytoplasmic cleavage.


Clinical aspects of the various forms of nonmedical use of drugs. I.


12S and 9S RNA species. Localization and fate during development of Strongylocentrotus purpuratus eggs.


It's not how you play the game--it's your form that counts.


Prevention of contamination of the circle system and ventilators with a new disposable filter.


A study of some aspects of plasma free insulin-like activity.


In vitro diagnosis of atopic allergy. II. IgE and reaginic antibodies during and after rush desensitization.


Bence Jones proteinemia and proteinuria in a dog.


Craniolateral approach to the canine hip: a modified Watson-Jones approach.


Ciliary body adenocarcinoma in the dog.

Ciliary body adenocarcinoma in the dog.


Progression of hip dysplasia in military working dogs.


Toxoplasmosis of the canine nervous system: clinicopathologic findings in four cases.


A review of 116 diaphragmatic hernias in dogs and cats.


Resection of diseased ileum in the horse.


What is your diagnosis?

What is your diagnosis?


Rare fungal infections in Kuwait.

Rare fungal infections in Kuwait.


Stimulation of staphylococcal and micrococcal growth in milk of lysed leukocytes.


Effect of high temperature and dietary fat on milk fatty acids.


Effect of feed consumption on plasma amino acid concentrations in lambs.


Method for experimental induction of ketosis utilizing the interaction of low energy intake and thyroxine.


Turnover rates of nucleic acids and extractable cell proteins in lactating rat and bovine mammary glands.


Short estrous cycles in New Zealand dairy cattle.


Metabolism of glycolic acid in lactating and nonlactating goats and in a calf.


Semen characteristics and chemistry from bulls before and after seminal vesiculectomy and after vasectomy.


Absorption of colostral immunoglobulins by newborn dairy calves.


Relationship of genotype and degree of chimerism in coat color to sex ratios and gametogenesis in chimeric mice.


Thyroid status and serum calcium depression at parturition.


[Clinical studies on serum sorbitol dehydrogenase].


In vitro experiments on the venous return from the intervillous space during uterine contraction.


Leiomyosarcoma of the colon with metastasis to the liver: right hepatic lobectomy in presence of variant hepatic artery.


Concurrent session: current trends in neurology and psychiatry.


Mechanisms of trauma during breech delivery.


Environmental levels of radioactivity at Atomic Energy Commission installations. 1. Savannah River Plant: January-June 1970.


Should psychiatry and neurology integrate?


The vicissitudes of the adoption process.


Paratuberculosis cutis caused by Mycobacterium marinum.


Hypoglycemia and infantile cataract.

Hypoglycemia and infantile cataract.


Inhibition of cholesterol side-chain cleavage by azacholesterols.


Two mechanisms for the inhibition in vitro of phenylalanine hydroxylase by catecholamines.


A general method for the specific isolation of peptides containing modified residues, using insoluble antibody columns.


Native and subunit molecular weights of apoferritin.


On the conformation of lysozyme and alpha-lactalbumin in solution.


Yeasts of the matador soils of Saskatchewan and their ability to use flavonoids.


Effect of immunosuppressive agents on antitumor action of lentinan.


Investigation of the pathogenic mechanisms in regional enteritis with in vitro lymphocyte cultures.


Transfer of  131 I from milk into cheese.


Mercury poisoning with central and peripheral nervous system involvement treated with penicillamine.


Cytogenetic, clinical and genealogical analyses in a series of gonadal dysgenesis patients and their families.


Complement in ABO--hemolytic disease of the newborn.


Social setting: influence on the physiological response to electric shock in the rat. A significant fall in tail blood pressure occurs in paired rats after shock-induced aggression. Pressure returns to baseline levels within 4 hours after fighting. Conversely, single rats subjected to jump threshold measurements or to shocks identical to those used in the aggression paradigm show significant elevations in tail blood pressure. The size of the pressure increase in rats shocked alone appears dependent on the intensity of the shocks, while the pressure fall in rats shocked in pairs occurs over a broad range of shock intensities.


On the affinity of rabbit-muscle glycogen phosphorylase for highly branched macromolecular subtrates.


Nonlinear kinetics of the xanthine oxidase reaction catalyzed by chicken liver xanthine dehydrogenase.


Purification and properties of pig liver mitochondrial monoamine oxidase.


The action of sweet potato -amylase on glycogen and amylopectin: formation of a novel limit dextrin.


Studies on bovine pancreatic ribonuclease A and model compounds in aqueous 2-methyl-2,4-pentanediol. I. Amino acid solubility, thermal reversibility of ribonuclease A, and preferential hydration of ribonuclease A crystals.


The molecular weights of glycerol-3-P dehydrogenases from chicken, rabbit, and honey bee.


Mechanism of action of thrombin on fibrinogen. II. Kinetics of hydrolysis of fibrinogen-like peptides by thrombin and trypsin.


Chromatographic separation of the enzymes required for hydroxylation of lysine and proline residues of protocollagen.


Isolation and properties of an inhibitor of phospholipase A from Bothrops neuwiedii venom.


The molecular size of enzymically active aldolase A.


Interchain disulfide bonds of goat immunoglobulin G.


Spleen-pineal gland correlations. Histomorphological and microfluoroscopic studies of the pineal gland in experimental methyl-cellulose hypersplenism.


Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase.


Local pathway controlling luteal function in the guinea pig.


Prolonged maintenance of the corpus luteum of the ewe by continuous infusion of luteinizing hormone.


Effects of isoimmunization and isoantisera against seminal antigens on fertility process in female rabbits.


Egg transport through the ampullae of the oviducts of rabbits under various experimental conditions.


Analysis of symptomatic course and prognosis and treatment of hypertrophic obstructive cardiomyopathy.


Virginal and gravid mammary gigantism--recurrence after reduction mammaplasty.


Synthesis of aminoethyl derivatives of alpha, omega-alkylenediamines and structure-activity relationships for the polyamine-bovine plasma amine oxidase system.


Dose and LET in a rabbit and a rat.

Dose and LET in a rabbit and a rat.


Role of echocardiography in diagnostic and hemodynamic assessment of hypertrophic subaortic stenosis.


Accidents in agriculture.

Accidents in agriculture.


Canine leptospirosis in Cairo.

Canine leptospirosis in Cairo.


Microbial contamination of nonsterile antibiotic market samples: a survey.


Coagulation studies on the peripheral circulation of patients with toxemia of pregnancy: a study for the evaluation of disseminated intravascular coagulation in toxemia.


6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity.


Is smoking teratogenic?

Is smoking teratogenic?


Local oxygen tension field in the glomus caroticum of the cat and its change at changing arterial PO 2 .


The solubility of carbon dioxide in Elasmobranch plasma between 10 degrees C and 22 degrees C.


The effect of renal arterial infusion of albumin on renal function in the rat.


Deformability and traversing time of shape-transformed single red cells passing through a 4   glass-capillary.


Adrenocortical activation during long-term exercise in dogs: evidence for a glucostatic mechanism.


The relation between the reabsorption of urea and of water in the distal tubule of the rat kidney.


Azide sensitive components of potassium efflux as influenced by the external sodium concentration.


Caesarian section in a zebra (Equus burchelli bömi).


Early detection of mastitis.

Early detection of mastitis.


Effect of oxyclozanide on feed efficiency in cattle with chronic fascioliasis.


Isolation of GAL virus from peripheral blood of a chicken.


Weight changes of the developing rat conceptus.


Psychological aspects of early mother-infant relationships.


A model neighborhood program at a Los Angeles health center.


The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro.


Molar absorptivity and A-1 -1cm values for proteins at selected wavelengths of the ultraviolet and visible region. I.


Interactions of hexamethylene tetramine with biopolymers and model compounds in aqueous solution.


Hydrogen ion titration of ionizable side-chains in native and denatured glycinin.


Simultaneous demonstration of exogenous horseradish peroxidase and acid phosphatase activities in phagolysosomes.


Synthesis and pharmacological effects of some alkyl-, aryl-, and aralkylsydnonimines.


Synthesis and antimitotic activity of glycosidic lignan derivatives related to podophyllotoxin.


Antihistomonal activity of ipronidazole and closely related nitroimidazoles.


Phenacylthioimidazolines and 3-aryl-5,6-dihydroimidazo(2,1-b)thiazoles with antidepressant activity.


Uretero-ileal conduit: modifications of the surgical technique.


Iatrogenic dislocation of the corpora cavernosa.


Scrotal wall hemangioma in an infant.

Scrotal wall hemangioma in an infant.


Intrauterine and newborn torsion of spermatic cord.


Complete longitudinal nephrolithotomy for staghorn calculi in children.


Effect of x-irradiation on survival of wild and laboratory rats.


Transformation of mammalian cells by crude histones. A baby hamster kidney cell line (BHK21), maintained in the presence of crude histone preparations for 3 days, has been shown to undergo morphological and behavioural transformations similar in nature to those obtained with viruses and mycoplasmas.


Cancer in Chiang Mai, North Thailand. A relative frequency study. The relative frequency of histologically diagnosed cancer at the Chiang Mai Medical School in North Thailand in 1964-67 inclusive is examined.Most of the 1877 cancers seen are in Thais (males, 927; females, 908), the remainder arising in Chinese (males, 21; females, 12), Hill People (males, 6; females, 1) and others (females, 2). The cancers in Thais are presented by site, sex and 10-year age-group together with the relative frequency (crude and corrected for age).In Thais, the outstanding finding is the extraordinarily high frequency of cancer of the hypopharyngeal-laryngeal region in both sexes (males, 18.4 per cent; females, 3.4 per cent). This may be associated with the smoking of a local variety of the cigar called "keeyo" This cigar, smoked in the usual manner, contains approximately equal quantities of home-grown, sun-dried, Thai tobacco and the chopped bark of the "koi" tree (Streblus asper). In women, who also smoke "keeyo", the frequency of hypopharyngeal-laryngeal cancer is unusually high by occidental standards. There is no sex difference in the frequency of bronchial cancer (4 per cent).In males cancer of the penis, in second rank (6.6 per cent) is much more frequent than cancer of the prostate and testis combined. Stomach and skin cancers (ICD 191) are in third place (each 5.7 per cent).In females the most frequent cancers are cervix uteri (19.8 per cent), breast (8.8 per cent) and skin (ICD 191) (6.1 per cent). Cancers of the lip and skin of the head and neck are more frequent in females than in males. Choriocarcinoma is common (1.9 per cent) and there is a large number of vulvar cancers in young women (2.6 per cent).The geography, economy and medical facilities of Chiang Mai Province are described. It is considered that, although there is likely to be considerable under-reporting of internal cancers, the high frequency of hypopharyngeallaryngeal cancer is not due to selective bias.


Histologic and electron microscopic observations on a tumor-bearing viper: establishment of a "C"-type virus-producing cell line.


Current information on feline and canine cancers and relationship or lack of relationship to human cancer.


Identification of prostaglandins in prevertebral venous blood after preganglionic stimulation of the cat superior cervical ganglion. 1. In four out of seven experiments, prostaglandin-like activity was detected in prevertebral venous blood from the superior cervical ganglion, collected during and after preganglionic nerve stimulation.2. Prostaglandins E(1), E(2), F(2alpha) and a prostaglandin A were identified using solvent partition, column and thin-layer chromatography and bioassay techniques.3. The release of PGF(2alpha) was confirmed by combined gas chromatography-mass spectrometry.


Action of 6-hydroxydopamine on lamb sympathetic ganglia, vas deferens and adrenal medulla: a combined histochemical, ultrastructural and biochemical comparison with the effects of reserpine. 1. The effects of a single dose of 6-hydroxydopamine (6-OHDA) compared with those of chronic reserpine treatment were studied in lamb sympathetic neurones and adrenal medulla by a combination of fluorescence histochemistry, electron microscopy and radiochemical assay.2. In sympathetic ganglia, 6-OHDA produced a rise in noradrenaline concentration within 24 h, and falls in tyrosine hydroxylase and monoamine oxidase activities, whereas reserpine caused a fall in noradrenaline, a rise in tyrosine hydroxylase activity and no change in monoamine oxidase activity. The fluorescence of intra- and postganglionic axons increased greatly within 24 h of 6-OHDA, and there was a corresponding accumulation of large dense-core vesicles within many axons whose neurotubules were disrupted. The changes were almost reversed after 3 weeks.3. In the vas deferens, the concentration of noradrenaline and tyrosine hydroxylase and monoamine oxidase activities had all fallen 24 h after 6-OHDA treatment and had started to recover 3 weeks later. In the adrenal medulla, 6-OHDA did not alter NA concentrations but increased tyrosine hydroxylase activity whereas reserpine depleted noradrenaline and increased tyrosine hydroxylase activity.4. The changes produced in sympathetic ganglia by 6-OHDA may be due both to a direct action on the axoplasmic transport of noradrenaline containing vesicles and indirectly to the reaction of the neurones to loss of the integrity of their axons.


Study of the contractile and electrophysiological maturation responses of the human foetal myocardium.


Autonomic receptors and choline uptake in embryonic chick myocardial cell cultures.


Fear response and aggressive behavior of hippocampectomized house rats.


Effect of destruction of the posterior hypothalamic area on the experimental allergic polyneuritis.


Varieties of adolescent creativity and the high school environment.


Dieldrin residues and cooking losses in pork loins.


Ultraviolet scanning of proteins on ordinary glass plates in thin-layer isoelectric focusing.


Separation of plasma thromboplastin antecedent from kallikrein by the plasma   2 -macroglobulin, kallikrein inhibitor. Plasma thromboplastin antecedent (PTA, factor XI) is an important intermediate in the intrinsic coagulation system, and plasma kallikrein has been implicated as a mediator of the inflammatory process. Whereas their biologic activities are functionally distinct, their identity as separate entities in plasma has not been fully established, and the nature of their plasma inhibitors has not been completely characterized. A partially purified preparation containing the clotting, tosyl arginine methyl ester (TAMe) esterase and kinin-producing activities of these substances has been prepared by DEAE-cellulose chromatography of a Celite eluate obtained from acid-treated human plasma. These activities were not separable by acrylamide gel electrophoresis nor by isoelectric focusing, their pI being approximately 8.7. Human plasma alpha(2)-macroglobulin has been shown to inhibit the proteolytic activity of kallikrein and to inhibit partially its TAMe esterase activity. An alpha(2)-macroglobulin, PTA, kallikrein incubation mixture was separated by gel filtration chromatography. The alpha(2)-macroglobulin formed a high molecular weight complex with kallikrein and appeared in early chromatographic fractions. The PTA-clotting activity was not inhibited by the alpha(2)-macroglobulin; 64% of the initial PTA activity was isolated in later fractions free of kallikrein-induced kinin-like activity. In contrast, clotting, TAMe esterase, and kinin-forming activities were inhibited after gel filtration chromatography of an incubation mixture of these activities and partially purified C1 inactivator (C1 esterase inhibitor). Electrofocusing of an incubation mixture of an activated PTA, kallikrein preparation, and alpha(2)-macroglobulin resulted in the isolation of a PTA fraction free of kallikrein proteolytic activity, and with 4% of the original TAMe esterase activity. In this manner, activated PTA and plasma kallikrein have been shown to be distinct substances, and methods have been introduced for the further purification of active coagulation factor XI.


A second study of anal papillae.

A second study of anal papillae.


Linear free energy relationships in the enzymatic hydrolysis of substituted benzoylcholine esters.


2-amino-5-nitroimidazoles.


Potential antineoplastics. 8. Synthesis and pharmacology of 6-methyl-2-thio-5-arylazouracils.


Retroperitoneal angiomyosarcoma: a case report.


An angled needle holder.

An angled needle holder.


Utilization of nursing talents in Bell Canada.


President's message.

President's message.


The training of nurse-clinicians.

The training of nurse-clinicians.


Interaction between Sindbis virus RNA and ribosomes from chick fibroblasts.


N-fluoroacetyl-alpha-D-glucosamine as a molecular probe of lysozyme structure by using ( 19 F) fluorine nuclear-magnetic-resonance techniques.


Hybrid fibrin: proof of the intermolecular nature of  -  crosslinking units.


Selective precipitation of ribonucleic acid from a mixture of total cellular nucleic acids extracted from cultured mammalian cells. A simple and reproducible method is described for precipitating RNA selectively from total mammalian-cell nucleic acids extracted by the phenol-sodium dodecyl sulphate procedure at pH8.0. Under specified conditions bulk RNA is precipitated almost quantitatively whereas bulk DNA remains in solution. Minor components of RNA (detected by pulse-labelling and chromatography on methylated albumin-kieselguhr) and rapidly labelled components of DNA containing single-stranded regions are also precipitated. The usefulness of the method is discussed in the context of isolating separately both RNA and DNA from cultured cells that are difficult to obtain in quantity.


Cytokinetic analysis of slowly proliferating bone marrow cells during recovery from radiation injury.


Anomalous stimulation of protein synthesis: evidence for translational control in primary cells.


Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. 1. The activities in rat tissues of 3-oxo acid CoA-transferase (the first enzyme involved in acetoacetate utilization) were found to be highest in kidney and heart. In submaxillary and adrenal glands the activities were about one-quarter of those in kidney and heart. In brain it was about one-tenth and was less in lung, spleen, skeletal muscle and epididymal fat. No activity was detectable in liver. 2. The activities of acetoacetyl-CoA thiolase were found roughly to parallel those of the transferase except for liver and adrenal glands. The high activity in the latter two tissues may be explained by additional roles of thiolase, namely, the production of acetyl-CoA from fatty acids. 3. The activities of the two enzymes in tissues of mouse, gerbil, golden hamster, guinea pig and sheep were similar to those of rat tissues. The notable exception was the low activity of the transferase and thiolase in sheep heart and brain. 4. The activities of the transferase in rat tissues did not change appreciably in starvation, alloxan-diabetes or on fat-feeding, where the rates of ketone-body utilization are increased. Thiolase activity increased in kidney and heart on fat-feeding. 5. The activity of 3-hydroxybutyrate dehydrogenase did not change in rat brain during starvation. 6. The factors controlling the rate of ketone-body utilization are discussed. It is concluded that the activities of the relevant enzymes in the adult rat do not control the variations in the rate of ketone-body utilization that occur in starvation or alloxan-diabetes. The controlling factor in these situations is the concentration of the ketone bodies in plasma and tissues.


Achondroplasia and thanatophoric dwarfism in the newborn.


Multiple carboxymethylation of histidines in bovine ribonuclease A.


The preoptico-neurohypophysial neurosecretory system in thyroidless Xenopus laevis larvae.


Ternary coordination complex between human serum albumin, copper (II), and L-histidine.


Activation of yeast pyruvate kinase by natural and artificial cryoprotectants.


Interacting systems of the type A + B = C.


The specificity of porcine elastase and  -chymotrypsin. Effect of fatty acid chain length in a homologous series of nitrophenyl esters.


Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent.


Sensitization to amphetamines.

Sensitization to amphetamines.


Conjoined twinning in rabbits.

Conjoined twinning in rabbits.


Idiopathic hypertrophic subaortic stenosis. Surgical treatment including mitral valve replacement.


Differences in the ribosomes prepared from lactating and non-lactating bovine mammary gland. 1. Ribosomes prepared from bovine lactating mammary gland are able to synthesize protein, whereas similar preparations from non-lactating glands are not. Washing the ribosome suspensions through a medium containing 0.5m-ammonium chloride enhanced their ability to incorporate phenylalanine into polyphenylalanine. 2. Ribosomes isolated from non-lactating bovine mammary gland, in contrast with those from rat liver and lactating mammary gland, contained significant amounts of extraneous nucleases. These enzymes could be removed by washing with a medium A buffer containing 0.5m-ammonium chloride. 3. Only those ribosomes from functionally active tissues were able to bind polyuridylic acid and phenylalanyl-tRNA.


Ultrasound in the investigation of space-occupying lesions of the urinary tract.


The radiosensitivity of melanoma cells in culture.


The radiosensitive tissues in bone.

The radiosensitive tissues in bone.


Studies on the porphobilinogen deaminase-uroporphyrinogen cosynthetase system of cultured soya-bean cells. 1. Porphobilinogenase was isolated and purified from soya-bean callus tissue; its components, porphobilinogen deaminase and uroporphyrinogen isomerase, were separated and purified. 2. The purified porphobilinogenase was resolved into two bands on starch-gel electrophoresis. The molecular weights of porphobilinogenase, deaminase and isomerase fractions were determined by the gel-filtration method. Porphobilinogenase activity was affected by the presence of air; uroporphyrinogens were only formed under anaerobic conditions, although substrate consumption was the same in the absence of oxygen as in its presence. 3. pH-dependence of both porphobilinogenase and deaminase was the same and a sharp optimum at pH 7.2 was obtained. Isomerase was heat-labile, but the presence of ammonium ions or porphobilinogen afforded some protection against inactivation. The action of several compounds added to the system was studied. Cysteine, thioglycollate, ammonium ions and hydroxylamine inhibited porphobilinogenase; certain concentrations of sodium and magnesium salts enhanced activity; some dicarboxylic acids and 2-methoxy-5-nitrotropone inhibited the deaminase. 4. delta-Aminolaevulate and ethionine in the culture media stimulated porphyrin synthesis and increased porphobilinogenase activity, whereas iron deficiency resulted in porphyrin accumulation. 5. The development of chlorophyll and porphobilinogenase on illumination of dark-grown callus was followed. 6. A hypothetical scheme is suggested for the enzymic synthesis of uroporphyrinogens from porphobilinogen.


Changes in the capacity for clonal growth and differentiation in vitro of the vertebral cartilage cells with embryonic development. II. Vitalizing effect of conditioned medium on the cells of younger embryos.


Transfer of insulin into the bile in rabbit late pregnancy.


Sorbitol in the eggs of the silkworm. Bombyx mori.


Studies on the acute effects of clinical angiocardiography on left ventricular function.


Synthesis and pharmacological properties of deaminotocinamide and a new synthesis of tocinamide.


On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine.


Extraluminal recording of oviductal contractions in the unanesthetized rabbit.


Effects of conflicting response requirements and shock-compartment confinement on the Kamin effect in rats.


Galactorrhea in males with tumors in the region of the pituitary gland.


Hydatid disease: another misleading leaflet.


Heterograft mitral and tricuspid valve replacements: a review of seven grafts.


Effects of beta and gamma radiation on a population of springtails, Sinella curviseta (Collembola).


DNA damage and repair following irradiation: the effect of 5-bromodeoxyuridine in cultured Chinese hamster cells.


Ultrastructural differences between the sinus and the Müllerian epithelium of the mouse vaginal anlage.


The mesocaval shunt for portal hypertension.


Remarks on the epidemiology and importance of onchocerciasis in Upper Guinea.


On the kinetics of liver enzyme regression following induction.


Conformational studies on the tryptic digestion fragments of human immunoglobulin G.


Cross-linking of  -chymotrypsin and other proteins by reaction with glutaraldehyde.


The binding of methyl orange to bovine serum albumin studied by frontal analysis in sephadex chromatography.


A quantitative difference in the activity of blood group A-specific N-acetylgalactosaminyltransferase in serum from A 1  and A 2  human subjects.


An investigation of the subunit structure and AMP-deaminases from rabbit and chicken muscle.


Carbohydrate and end group analyses of ovine FSH.


Affinity of protoheme for the apoprotein of cytochrome b 2 .


On inactive precursor of cathepsin D from chicken liver.


Template activity of chromatin during stimulation of cellular proliferation in human diploid fibroblasts. 1. Contact-inhibited confluent monolayers of WI-38 human diploid fibroblasts can be stimulated to divide by replacing the medium with fresh medium containing 30% foetal calf serum. 2. Of the cells 40-75% are stimulated to divide with a peak DNA synthesis between 15 and 21h and a peak mitotic index between 28 and 30h after stimulation. 3. In the first 12h before the initiation of DNA synthesis there is a biphasic increase in the incorporation of [(3)H]uridine into RNA of whole cells. 4. This is paralleled by a similar biphasic stimulation of chromatin template activity measured in vitro in a system in which purified cell chromatin is incubated with an exogenous RNA polymerase isolated from Escherichia coli. 5. The changes in chromatin template activity are believed to represent activation of the genome, with more sites available for RNA synthesis, and to account almost entirely for the changes in RNA synthesis occurring in the whole cell.


Community college health services: a health care crisis.


Amino acid sequences around the cysteine residues of rabbit muscle triose phosphate isomerase. 1. The nature of the subunits in rabbit muscle triose phosphate isomerase has been investigated. 2. Amino acid analyses show that there are five cysteine residues and two methionine residues/subunit. 3. The amino acid sequences around the cysteine residues have been determined; these account for about 75 residues. 4. Cleavage at the methionine residues with cyanogen bromide gave three fragments. 5. These results show that the subunits correspond to polypeptide chains, containing about 230 amino acid residues. The chains in triose phosphate isomerase seem to be shorter than those of other glycolytic enzymes.


Contraction of the spleen following needle puncture: significance in studies of portal hypertension.


Ultrasonic examination of the hemoglobin dissociation process in aqueous solutions of guanidine hydrochloride.


Synthesis and central nervous system effects of some benzothiazinones.


Ciliary structure, ciliogenesis, microvilli. (Electron microscopy of the mucosa of the upper respiratory tract).


The importance of diagnostic syndromes in the drug treatment of hyperkinesis.


Preoperational radiological surveillance of the Florida Power Corporation's Crystal River power reactor site.


Evaluation of the sampling frequency of the pasteurized milk network.


Permanent deficit of neurones in cerebral and cerebellar cortex following early mild undernutrition.


An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides. In an anaerobic system soya-bean lipoxygenase together with linoleic acid induces a structural rearrangement of 13-hydroperoxyoctadeca-cis-9-trans-11-dienoic acid leading to the formation of 13-oxotrideca-cis(trans)-9-trans-11-dienoic acid and n-pentane as well as 13-oxo-octadeca-9,11-dienoic acid. It is proposed that the 13-peroxyoctadeca-cis-9-trans-11-dienoic acid radical formed through hydrogen radical abstraction by the linoleic acid radical is the key intermediate for these reactions.


Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells.


Differential efferent projections of the lateral and medial septal nuclei to the hippocampus in the cat.


Interaction of some daunomycin derivatives with deoxyribonucleic acid and their biological activity.


Adaptive value of hearing and vision in kangaroo rat predator avoidance.


Differential localization of progesterone uptake in brain. Role of sex, estrogen pretreatment and adrenalectomy.


Differential effects of hyperphenylalaninemia on the development of the brain in the rat.


Studies on leukocyte phosphatases. 3. Inhibition of leukocyte acid phosphatase by zinc.


Karyological patterns and expression of malignancy in some homologous mouse somatic hybrid cells.


Total synthesis of polymethoxyoestrane compounds. I. Synthesis of (+)-2,3,4-trimethoxyoestra-1,3,5(10)-trien-17-beta-ol and related compounds.


Eupacunin, a novel antileukemic sesquiterpene lactone from Eupatorium cuneifolium.


Effect of testosterone and of some of its 17-hydroxylated metabolites on the müllerian duct of the foetal rat, in organ culture.


Liatrin, a novel antileukemic sesquiterpene lactone from Liatris chapmanii.


Total synthesis of polymethoxyoestrane compounds. II. Synthesis of (+)-2,4-dimethoxyoestra-1,3,5(10)-trien-17-beta-ol.


The gentamicin antibiotics. II. Separation and degradation of the gentamicin C components. The purpurosamines, a new class of naturally occurring 2,6-diaminomonosaccharides.


Conditioned suppression produced in rats by tones paired with escapable or inescapable shock.


MCAT scores in relation to personality measures and biographical variables.


The laboratory in community medicine: examples from Northern Thailand.


Capillaria and Hymenolepis in a wild rat: hazards to barrier-maintained laboratory animals.


Amounts and turnover rates of brain proteins in morphine-tolerant mice.


Child care centre for Aboriginal children.


Spontaneous lactation in virgin Sprague-Dawley rats.


Lancefield type C streptococcal infections in strain 2 guinea-pigs.


Operative delivery in obstetrics.

Operative delivery in obstetrics.


Vitamin K1.

Vitamin K1.


Effect of A1PO4 on antibody response.

Effect of A1PO4 on antibody response.


Immunogenicity of cytolipin H aggregated with Acholeplasma laidlawii membrane proteins.


Corpus luteum action on ovarian follicular development after destruction of macroscopically visicle follicles in ewes.


Oxytocic activity in posterior pituitary glands of male rats measured by two bioassays.


Studies on lectins with a broad agglutination spectrum. XII. N-acetyl-D-galactosamine specific lectins from the seeds of Soja hispida, Bauhinia purpurea, Iberis amara, Moluccella laevis and Vicia graminea.


Gonocytes in fetal guinea pig testes: phagocytosis of degenerating gonocytes by Sertoli cells.


Some evolutionary aspects of human gender.


Application of a specific-ion electrode to the determination of disulfide groups in proteins.


An automated rate analysis of lipase, trypsin, and chymotripsin reactions by constant pH titration.


Molecular sieve studies of interacting protein systems. 8. Critical evaluation of the equilibrium saturation technique using stacked gel columns.


Radiochromatographic assay for thiol groups of soluble proteins using mercury-203 labeled methylmercury.


General enzyme studies with a substrate-selective electrode: characterization of cholinesterases.


Hexosamine interference with the determination of protein by the Lowry procedure.


Assay for phospholipase A activity of snake venom with asolectin as substrate.


Impairment of herpesvirus growth in chick embryo fibroblast cultures by  -amanitin. Brief report.


Bovine virus diarrhoea virus: inhibition of growth by proflavine sulphate. Brief report.


Hydrogen ion titration curve of lysozyme in 6 M guanidine hydrochloride.


Exposure of the tyrosyl and tryptophyl residues in trypsin and trypsinogen.


Complete hydrolysis of branching linkages in glycogen by Pseudomonas isoamylase: distribution of linear chains.


Cyclic-voltammetric determination of cysteine in rat organs after intravenous injection.


Stability characteristics of deuterated myoglobin.


The effect of gonadotrophins on the in vitro growth of the free-living nematode Cephalobus sp. Bastian.


The prenatal development of the dog: preimplantation events.


Geraldius n. gen., Macrolaiminae n. subfam., with a revision of the subfamilies and genera of Chambersiellidae (Nematoda).


Cholestyramine and nicotinic acid in the treatment of familial hyperbetalipoproteinaemia in the homozygous form.


Lactate dehydrogenase isozymes of Xenopus laevis: factors affecting their appearance during early development.


Genetic control of qualitative changes in protein synthesis during early amphibian (Mexican axolotl) embryogenesis.


Cooking techniques for broiler chickens.


Pharmacy and the health manpower crisis.


Idiopathic thrombocytopenic purpura with normal platelet survival time. Platelet survival has been measured in 16 patients with idiopathic thrombocytopenic purpura. Of this group, three patients had a normal result and surface counting did not show high splenic uptake. The clinical features of these patients are described. These patients have remained well for several years without treatment.


The role of psychosocial factors in the development of arteriosclerosis in CBA mice. Observations on the heart, kidney and aorta.


Ink-blot responses of identical and fraternal twins.


Q fever in Ireland. Survey of cattle and sheep sera in the Republic of Ireland.


Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma. A severe, pure deficiency of factor VII has been defined in haematological and biochemical terms in the Alderley Park colony of beagle dogs. By modification of the conventional factor VII assay to improve its specificity an apparent low activity of between 1 and 2.5% of the normal beagle has been found. When this plasma is used as a substrate for factor VII assays it compares well with human factor VII-deficient plasma in the measurement of both raised and depressed factor VII activity. It also appears to be a valuable reagent in the quality control of tissue thromboplastin extracts.


Genetic factors in tests of perception and the Rorschach.


Inhibition by nucleotides of mouse brain UDPgalactose 4-epimerase in vitro.


The free amino acids of foetal brain in Tay-Sachs disease.


[Clinical studies on the relation between aldosterone and various hypertensive and renal diseases. 1. Studies on the secretion and metabolism of aldosterone in various hypertensive and renal diseases].


Toward a theory of early infantile autism.


Hemagglutination inhibition with arboviruses: relationship between titers and source of erythrocytes. Antigens for Grand Arbaud, Hazara, and California arboviruses were able to agglutinate goose and either dog, hamster and guinea pig, or hamster red blood cells (RBC) to the same titer at the same pH; in hemagglutination-inhibition (HI) tests, titers for homologous and related sera were the same with these different types of RBC or occasionally one dilution higher with the mammalian cells. Antigens for St. Louis encephalitis and Eastern equine encephalitis viruses required use of lower antigen dilutions with human, guinea pig, and hamster RBC than with goose RBC. The results of comparative HI testing with these latter antigens and types of RBC indicate that HI titer is not directly related to the antigen dilution used with different types of RBC.


Antifungal activity of substituted nitrobenzenes and anilines. Series of 1,3-dihalogeno-5-nitrobenzenes, 3- and 3,5-halogenoanilines, and 2,6-dihalogeno-4-nitroanilines were tested for fungitoxicity against Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes in shaken culture by using Sabouraud dextrose broth enriched with yeast extract as the test medium. 1,3-Dichloro-5-nitrobenzene, 1,3-dibromo-5-nitrobenzene, 3-iodoaniline, 3,5-dichloroaniline, and 3,5-dibromoaniline were found to possess sufficient activity, compared with 8-quinolinol, to warrant further study.


Pithomyces chartarum, a mycotoxin-producing fungus, isolated from seed and fruit in Oregon.


Rubella virus hemagglutination with a wide variety of erythrocyte species. In HEPES diluents, rubella antigens agglutinated a wide range of species of erythrocytes, and the hemagglutination reaction showed little or no dependence on low temperatures.


Reduction of nucleic acid content in Candida yeast cells by bovine pancreatic ribonuclease A treatment. Yeast as a source of protein for human consumption is limited by its relatively high nucleic acid content. In this study, we developed an enzymatic method of decreasing the nucleic acid content. Candida utilis cells, heat-shocked at 80 C for 30 sec, were treated with bovine pancreatic ribonuclease A. Maximum leakage of nucleic acid was observed when the incubation temperature was between 55 and 65 C, the pH of the system from 6.75 to 8.0, and the enzyme-to-cell ratio 1:10,000 on a weight-by-weight basis. Other factors, such as yeast strain, age of cells, and method of propagation, did not influence the susceptibility of the yeast cells to the action of ribonuclease. Buffers and monovalent cations had no inhibiting effects. Magnesium and calcium ions at concentrations greater than 0.001 m showed marked inhibition on the rate of nucleic acid leakage. This enzymatic method reduced the nucleic acid content of yeast cells from 7.5 to 9.0% to 1.5 to 2.0% with no significant concomitant loss of protein.


New records of mushroom stones from Guatemala.


Modification of carboxyl groups in bovine carboxypeptidase A. I. Inactivation of the enzyme by N-ethyl-5-phenylisoxazolium-3'-sulfonate (Woodward's reagent K).


Modification of carboxyl groups in bovine carboxypeptidase A. II. Chemical identification of a functional glutamic acid residue and other reactive groups.


pK change of imidazole groups in bovine serum albumin due to the conformational change at neutral pH.


Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants.


Studies on phospholipase A and its zymogen from porcine pancreas. 3. Action of the enzyme on short-chain lecithins.


Cholesterol uptake by egg-yolk phosphatidylcholine.


Disappearance of retino-epithelial scar tissue from ruby laser photocoagulations.


A parametric analysis of bone fixation plates on fractured equine third metacarpal.


Rapid electrophoretic microzone membrane technique for Regan isoenzyme (placental type alkaline phosphatase) usine a fluorogenic substrate.


An implantable incontinence device.

An implantable incontinence device.


An investigation of some factors affecting cross-reactivation between influenza A viruses.


Purification of oat necrotic mottle virus with silver nitrate as clarifying agent.


Studies on the assembly of Newcastle disease virus: incorporation of structural proteins into virus particles.


Inhibition of host-specific DNA and RNA synthesis in KB cells following infection with frog virus 3.


Mercury pollution--a fish story.

Mercury pollution--a fish story.


Restoration of function after apparent tuberculous autonephrectomy.


Carcinoma of the scrotum, radical excision and repair using ox fascia: case report.


Mature form of the deoxyribonucleic acid from chick embryo lethal orphan virus. The deoxyribonucleic acid (DNA) of chick embryo lethal orphan (CELO) virus, an oncogenic avian adenovirus, had a biphasic denaturation profile indicating intramolecular base composition heterogeneity. This was confirmed by shearing the DNA and centrifuging it to equilibrium in Cs(2)SO(4) in the presence of HgCl(2) when two bands were formed. No circular molecules formed when CELO virus DNA was annealed, although lambda DNA formed circles under the same conditions. No circular molecules were found by sedimentation or electron microscopy when the DNA was digested with exonuclease III and then annealed, but 30 to 40% of T7 DNA molecules became circular under similar conditions. The complementary strands of CELO virus DNA both appeared to be continuous, and, when CELO DNA was denatured and then annealed under appropriate conditions, all of the renatured molecules were linear. It is concluded that CELO virus DNA consists of a unique rather than permuted collection of linear molecules that lack exposed single-strand complementary ends or duplex terminal repetitions. These results are discussed in relation to the replication of viral DNA and the transformation of host cells.


Transfer of 6-azauridine through the placental barrier in the rat.


Comparison of effects of cyclophosphamide, Cytembena, and Ypenyl in the treatment of inoperable ovarian carcinoma.


Sound-induced seizures during ethanol withdrawal in mice.


EEG correlates of morphine challenge in post-addict rats.


Radiosensitization with 5-bromodeoxyuridine of Chinese hamster cells x-irradiated during different phases of the cell cycle.


Some plant virus-beetle vector relations.


Induction of sugar uptake by a hamster pseudotype sarcoma virus.


Establishment of lactation.

Establishment of lactation.


Cost-value and selection of milks for use in artificial feeding.


Aorta to coronary artery bypass grafts combined with intracardiac procedures for acquired heart disease.


The isolation of acidic nuclear proteins from Physarum polycephalum.


The reaction of monoamine oxidase with phenethylhydrazine.


Structural studies on bovine  -crystallin. The amino acid sequences around the cysteine residues in the lens protein, gamma-crystallin, were studied. Fraction II of the gamma-crystallin from calf lens (Björk, 1964) was used. The protein was oxidized with performic acid and then hydrolysed with trypsin. Six peptides containing cysteic acid were isolated. One of the peptides contained three residues of cysteic acid and the others contained one residue of cysteic acid. We conclude that there are eight unique residues of cysteic acid in the oxidized protein. Amino acid analysis suggests that there are also eight residues of cysteic acid in the molecule, which thus contains only one polypeptide chain.


C-terminal amino acid sequence of bovine  -crystallin.


Effects of continuous competition in two species of cellular slime mold: Dictyostelium discoideum and Polysphondylium pallidum.


Monogenetic trematodes from the Bay of Quinte area, Ontario. II. Genus Gyrodactylus Nordmann, 1832.


The systematic status of the African molossid bats Tadarida bemmeleni and Tadarida cistura.


In vitro cultivation of hemocytes of Malacosoma disstria Hübner (Lepidoptera: Lasiocampidae).


Aggressive behavior of Apis mellifera L. workers towards introduced queens. 3. Relationship between the attractiveness of the queen and worker aggression.


Post-traumatic amnesia.

Post-traumatic amnesia.


The requirement for macrophages in the in vitro immune response.


Hypertrophic subaortic stenosis with ostium secundum atrial septal defect.


Sociogenetic brain damage.

Sociogenetic brain damage.


Sulfur amino acid nutrition of the growing chick: quantitative aspects concerning the efficacy of dietary methionine, cysteine and cystine.


Utilization by rats of protein from a trypsin-inhibitor variant soybean.


Bloat in cattle. XV. The relation of viscosity and cell-free polysaccharide content of rumen fluid to feedlot bloat.


LH and prolactin in blood serum from estrus to ovulation in Holstein heifers.


Effect of lactation and energy intake on postpartum ovarian activity in the cow.


Oxytocin and the secretion of luteinizing hormone in cattle.


Influence of ammonium salts of volatile fatty acids upon ration digestibility, rumen fermentation and nitrogen retention by steers.


Some effects of obesity in beef females.


Genetic and phenotypic parameters including occurrence of estrus in rambouillet ewe lambs.


Protein requirements of milking cows.

Protein requirements of milking cows.


Corn gluten feed in swine diets and effect of pelleting on tryptophan availability to pigs and rats.


Seasons of calving: age, management, and genetic differences for milk.


Failure of oxytocin to initiate prolactin or luteinizing hormone release in lactating dairy cows.


Nitrogen additions to high moisture corn and its utilization by ruminants.


Estimation of lower critical temperatures for dry and lactating dairy cows.


A mathematical simulation of body burden with inhaled mercury vapor.


20-hydroxyecdysone, what it can do.

20-hydroxyecdysone, what it can do.


Causes of death in captive wild waterfowl in the Kortright Waterfowl Park, 1967-1970.


The cytotoxic effect on human lymphocytes of rabbit antisera to human Fc (IgG).


The occurrence of Setaria in reindeer.

The occurrence of Setaria in reindeer.


Helminth parasites in snowshoe hares from northern Michigan.


Infectious pancreatic necrosis virus--temperature and age factors in mortality.


Occurrence of Capillaria hepatica (Nematoda: Trichuridae) in the spotted skunk in Florida.


Gastric ulcers associated with Contracaecum SPP. (Nematoda: Ascaroidea) in a Steller sea lion and a white pelican.


Some histopathological lesions caused by helminths in marine mammals.


Elaeophora poeli (Nematoda: Filarioidea) in African buffalo in Uganda, East Africa.


Polydactylism in a barren-ground caribou from northwestern Manitoba.


The pathology of Filaria taxideae (Filarioidea: Filariidae) infection in the badger.


Ventricular function in idiopathic hypertrophic subaortic stenosis. A ballistocardiographic and angiographic correlative study.


Fate of the patient with the Eisenmenger syndrome.


Reversal of hemodynamic and phonocardiographic abnormalities in idiopathic hypertrophic subaortic stenosis.


Clinical observations of necrosis of the skin of suckling piglets.


Cyclophosphamide in the treatment of mycotic dermatitis of sheep.


Some observations on the use of drugs for the capture of feral buffalo.


Crowding without stress.

Crowding without stress.


Rhabdomyosarcoma of the lungs of a sheep.


Correlations of electrocardiographic pattern, shape of ventricular septum, and isovolumetric relaxation time in irregular hypertrophic cardiomyopathy (obstructive cardiomyopathy).


Metabolites of Verticillium dahliae: the isolation and structure elucidation of some disaccharides and a trisaccharide.


Pathways of purine ribonucleotide catabolism in Ehrlich ascites tumor cells in vitro.


Rapid induction of sarcomas in rats by combination of nickel sulfide and 3,4-benzpyrene.


Multigeneration studies on the effect of dietary DDT on the vitamin A status of the weanling rat.


The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture.


Histochemical demonstration of 3 alpha-hydroxysteroid dehydrogenase activity in cultured ovarian granulosa cells in swine, Sus scrota.


The composition of nerve induced canine prostatic secretion.


Renal pelvic carcinoma in a cat.

Renal pelvic carcinoma in a cat.


Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases.


Toxicity of famfur to young Brahman heifers and bulls.


RElation of the human antibody response to flagellin to GM genotype.


Ovine fascioliasis in California.

Ovine fascioliasis in California.


Antigen binding cells. II. Effect of highly radioactive antigen on the immunologic function of bone marrow cells.


Specific vulnerability of the largest telocentric chromosome of rat bone marrow cells to 7,12-dimethylbenz[a]anthracene.


Industry's nurses and collective bargaining. A statement by the American Association of Industrial Nurses, inc.


Nurse is friend to the girls who fly.

Nurse is friend to the girls who fly.


Who killed Staph Rose? The story of Minocin.


Toward a solution to absenteeism.

Toward a solution to absenteeism.


Immunocompetence of embryonic hemopoietic cells after traffic to thymus.


An outbreak of Venezuelan equine encephalomeylitis in Central America. Evidence for exogenous source of a virulent virus subtype.


Studies in the epidemiology of myxomatosis in California. IV. The susceptibility of six leporid species to Californian myxoma virus and the relative infectivity of their tumors for mosquitoes.


The epidemic potential of Brazilian myxoma virus (Lausanne strain) for three species of North American cottontails.


Malignant vascular endothelial tumor with distal embolization. A new entity.


A bicellular mechanism in the immune response to chemically defined antigens. II. Immunological tolerance.


A bicellular mechanism in the immune response to chemically defined antigens. 3. Interaction of thymus and bone marrow-derived cells.


Osteoarthritis associated with osteopetrosis treated by total hip replacement arthroplasty. Report of a case.


Suppression of chick pancreatic xanthine dehydrogenase by unnsaturated fatty acids.


Plasma estrogen and progesterone levels in cows prior to and during estrus.


Control of the proestrus surge of prolactin and luteinizing hormone secretion by estrogens in the rat.


Age-dependency of various protein methylases.


Effect of LH on peripheral progesterone concentrations in intact and hysterectomized heifers.


Synthesis and release of prolactin and growth hormone in vitro during the estrous cycle of the rat.


Cellular events concerning the developmental potentiality of the transplanted nucleus, with reference to the aging lens cell.


Age changes in the relationship among endocrine glands of the beagle.


[Misdirection syndrome in oculomotor nerve palsy].


Evidence of tool-using by chimpanzees in the Ivory Coast.


Pulmonary embolus and testicular atrophy in a gorilla.


Inductive formation of cellulase by sophorose in Trichoderma viride.


Spectral changes of porcine trypsin induced by divalent cations.


Inbreeding and variance effective numbers in populations with overlapping generations.


Effects of punishing the coping response (conflict) on stress pathology in rats.


Mössbauer effect of metmyoglobin and its hydrogen peroxide compound.


Amnesia produced by brief electrical stimulation of amygdala or dorsal hippocampus in cats.


Calf thymus alanine-rich, leucine-rich histone: sequences of the tryptic peptides and characteristic distributions of the basic and other residues in the molecule.


Effects of coping behavior in different warning signal conditions on stress pathology in rats.


Effects of coping behavior with and without a feedback signal on stress pathology in rats.


Mechanisms of territorial marking in the male and female Mongolian gerbil (Meriones unguiculatus).


Neural pathways involved in the ventromedial hypothalamic lesion syndrome in the rat.