Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man. The absorption of cholesterol has been studied in man by perfusing the upper jejunum with a micellar solution of bile salt, 1-monoglyceride, and cholesterol-(14)C, with a triple lumen tube with collection sites 50 cm apart. The absorption of micellar components between the collection sites was calculated from their concentration changes relative to those of the watersoluble marker, polyethylene glycol. Control experiments were performed with cholesterol-free perfusions of saline or bile salt-monoglyceride solutions. Steady state conditions were obtained.Each of the components of the micelle was absorbed to a different extent during passage through the test segment of jejunum. Bile salt was not absorbed (mean, -3%), but micellar monoglyceride was rapidly hydrolyzed and absorbed almost completely (mean, 98%). Cholesterol radioactivity was absorbed to an intermediate extent (mean, 73%), and the absorption of chemically determined cholesterol (mean, 46%) indicated that much of the disappearance of radioactivity represented true absorption and not simple exchange. The specific activity of the perfused cholesterol fell during passage through the loop. This fall was interpreted as signifying the continuous addition of nonradioactive endogenous cholesterol by the test segment. However, the decrease in specific activity may also be considered to signify exchange, in that nonradioactive molecules entered the lumen as radioactive molecules were absorbed. Plant sterols appeared in the intestinal contents during the perfusion and must have been contributed by the perfused segment. The perfusate and samples taken from the upper and lower collection sites were examined by ultracentrifugation to define the physical state of cholesterol. It was found that cholesterol in the perfusate or upper collection site samples did not sediment, but that 23% of the cholesterol in the lower collection site samples was sedimentable (mean of three experiments); bile salt, as control, was not sedimentable. Solubility experiments in model systems showed that cholesterol possessed low solubility in bile salt solution; its solubility increased markedly and in linear proportion to the amount of fatty acid or monoglyceride or both that was added to the bile salt solution. These findings suggest that polar lipid such as fatty acid or monoglyceride as well as bile salt is essential for normal micellar solubilization of cholesterol in intestinal content. They suggest the necessity of considering an insoluble sedimentable phase of particulate sterol in intestinal content as well as an oil and micellar phase for a complete description of sterol absorption. The marked difference in the rates of absorption of individual micellar components suggests that micellar lipid is not absorbed as an intact aggregate and is consistent with the view that polar lipid such as fatty acid is absorbed in molecular form by diffusion from a micellar solution. The experiments confirm previous findings demonstrating that fat absorption without bile salt absorption occurs in the upper small intestine in man.


Release of nonsedimentable platelet factor 3 during coagulation.


Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries. The average plasma testosterone concentration of women with either hirsutism or polycystic ovaries and hirsutism was higher (p < 0.01) than that of normal women although the ranges overlapped. Testosterone blood production rates averaged 830 +/- 120 SE and 1,180 +/- 310 SE mug per day in the two groups of hirsute women and 230 +/- 33 SE mug per day in normal women. The ranges did not overlap. The testosterone metabolic clearance rates of hirsute women (1,090 +/- 140 SE L per day) and of men (1,240 +/- 136 SE L per day) were significantly higher than those of normal women (590 +/- 44 SE L per day). These differences persisted when the metabolic clearance rates were corrected for surface area. We suggest that testosterone metabolic clearance rates vary directly with some function of testosterone production. The mean plasma androstenedione levels (2.8 +/- 0.35 SE and 2.8 +/- 0.30 SE mug per L) and production rates (6,060 +/- 450 SE and 7,360 +/- 345 SE mug per day) of the women with hirsutism or polycystic ovaries, respectively, were significantly higher than those of normal women (1.5 +/- 0.22 SE mug per L; 3,300 +/- 830 SE mug per day). The androstenedione metabolic clearance rates were the same in each group. Plasma androstenedione was the precursor of 49% of plasma testosterone in normal women and of 26% of plasma testosterone in hirsute women. Thus, 74% of the plasma testosterone in these subjects must have been either secreted or derived from a precursor that did not enter the plasma androstenedione pool.


The estimation of 3,4-dihydroxymandelic acid in urine and its excretion by man.


Electrophoresis of hemoglobins following the application of whole blood samples to acrylamide gel.


Estimation of human calcium absorption by external radioisotope counting.


Estimation of conjugated epinephrine and norepinephrine in urine.


Heme and prophyrin synthesis in sideroblastic anemia.


Studies on the anticoagulant action of heparin, protamine, and Polybrene in the activation of factor IX.


A lipid-soluble inert indicator in fat absorption studies in the rat.


Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability.


The postphlebitic syndrome and varicose veins.


Effective treatment of pruritus vulvae due to Candida.


Gas gangrene: successful treatment with hyperbaric oxygenation.


The teaching of rehabilitation medicine in American medical colleges.


The clinical education of the medical student.


Medicine and medical education in China.


Teaching and research in the basic medical sciences in the People's Republic of China, 1965.


Medical school expenditures for regular operating programs.


Salivary electrolytes, urea nitrogen, uric acid and salt taste thresholds in hypertension.


Absence of characteristic reactions in the periodontium and other peripheral tissues of hamsters showing neurophysiologic response to chronic administration of 5,5-diphenylhydantoin (dilantin).


Inactivation of thrombin by oxidized cellulose.


Periodontal pathosis in man. XVII. Effect of glucose drinks upon clinical tooth mobility.


The effect of an automatic toothbrush on periodontitis.


Stability evaluations of furfuryl ether solutions.


The effect of fluoridated drinking water on tissue respiration of rat kidney.


The basis of the low-amplitude discharge produced by acetycholine injection in sympathetic ganglia.


Influence of ouabain on the positive inotropic responses to norepinephrine in isolated guinea-pig and dog heart preparations at 37 degrees and 27 degrees.


Influence of norepinephrine and ouabain of cardiac muscle mechanics during hypothermia.


Inhibition of sympathomimetic effects on the cardiovascular system by 4-(2-isopropylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride (MJ 1999).


The actions of histamine on the mammalian heart.


Influence of myocardial activity on the rate of onset of ouabain action.


Effects of hydroxyamphetamine (paredrine) on the function of the sympathetic nervous system in normotensive subjects.


Studies on the absorption, excretion and metabolism of dimethylsulfoxide (DMSO) in man.


Metabolic fate of beta-(3,4-dimethoxyphenyl)-ethylamine in man.


The effect of 5-hydroxytryptamine on sodium transport in frog skin.


Caffeine effects on radiocalcium movement in normal and denervated rat skeletal muscle.


Glycogen depletion in the newborn rat liver: an electron microscopic and electron histochemical study.


The microstructure of fossil teeth.

The microstructure of fossil teeth.


A micromethod for fixation and embedding of separated blood cell fractions for electron microscopy.


Changes in nucleolar ultrastructure associated with differentiation in the root tip.


Lamellar bodies in the synaptic cytoplasm of the accessory cone from the chick retina as revealed by electron microscopy.


Componential analysis. Kinship studies in cultural anthropology are producing a new tool for semantic analysis.


Technology: academy panel sees need for enhancing applied science.


Living relative of the microfossil Kakabekia. A living, ammonia-obligate, umbellate form, similar to the Precambrian microfossil Kakabekia umbellata Barghoorn, has been isolated from two soil specimens collected at Harlech, Wales. This organism is amenable to culture on agar and in broth. The two soil specimens are similar in that they differ from a typical clay loam in high content of carbon, hydrogen, and organic nitrogen and low levels of sodium, potassium, and titanium. In all other constituents, such as calcium, magnesium, and iron, they are quite dissimilar. Kakabekia-like forms can be grown in glucose-anmonia media with the latter as the sole source of nitrogen, but they can also be grown on peptone and silicate in glucose-free media. Ammonia is necessary, and growth is always slow without glucose. The fission process was not observed, but the enlargement and differentiation of a preumbellate structure into its "mature" form, followed by disintegration (senescence) of this stage, was seem. An ontogeny is proposed in which the stalk and basal bulb of the complete umbellate structure are assumed to be part of the reproductive appartus.


Mitochondrial-satellite and circular DNA filaments in yeast. Mitochondrial DNA of Saccharomyces cerevisiae contains a satellite DNA (density, 1.682) that appears to exist as open-ended filaments at least 5 microns long. DNA from intact cells contains circular filaments whose lengths vary from 0.5 to 7 microns, with a great majority at 1.95 microns. The circular DNA has a density similar to that of the major nuclear peak (1.697). When heat-denatured mitochondrial-satellite DNA is renatured, it cross-links to form a molecule that is larger than the native molecule. The formation of cross-links results in hypersharpening of the density profiles in cesium chloride and also leads to failure to pass Millipore filter paper.


Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro. The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.


Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside. Survival of mice bearing different transplantable leukemias and treated with cytosine arabinoside was compared with uptake and subsequent phosphorylation of the drug in vitro. Capacity for nucleotide formation was correlated with response and is apparently an important determinant of drug sensitivity. Drug uptake, although apparently mediated, was similar in all cell lines.


Catalysis of ester hydrolysis by mixed micelles containing N-alpha-myristoyl-L-histidine. Model compounds are described for the study of the properties of amino acid side chains in the surface of micelles. Mixed micelles of N-(alpha)- mnyristoyl-L- histidine and cetyltrimethylammonium bromide catalyze the hydrolyses of p-nitrophenyl acetate and p-nitrophenyl caprylate at much higher rates than imidazole or histidinie do. The reaction shows a kinetic behavior similar to that of surface-catalyzed reactions.


Food intake controlled by a blood factor. Intake of food by hungry rats was reduced 50 percent below normal after their blood had been mixed with that of satiated rats. Intake of food by deprived rats was not reduced when the donor rat was deprived of food for 24 hours prior to mixing of the blood or when a deprived donor was fed to satiety immediately before such transfusion.


Strophanthidin-sensitive transport of cesium and sodium in muscle cells. Uptake of cesium-134 ions into muscle cells is reduced to very low values by the presence of 10(-5)M strophanthidin in the Ringer solution. Cesium ions can induce extrusion of sodium from muscle cells in which the intracellular sodium content is elevated. The cesium-induced extra efflux of sodium-22 is inhibited by the external presence of 10(-5)M strophanthidin. The coupling between inward movement of cesium and outward movement of sodium appears to be chemical in nature. The evidence suggests that cesium ions are transported into muscle cells by a system of sites or carriers that requires a source of metabolic energy for ion turnover to occur.


Spruce budworm mortality as a function of aerial spray droplet size. The size and number of aerial spray drops impinging on spruce budworm in its conifer forest habitat were determined by means of a new tracer method that uses fluorescent particles in a liquid spray. Examination of 1113 larvae affected by an experimental insecticide that had been applied to a 5000-acre (2024-ha) test area in Montana showed that 93 percent had not been contacted by any droplets larger than 50 micro in diameter. Small numbers of droplets 50 to 100 micro in diameter were found on 7 percent of the larvae, along with lethal numbers of smaller drops. No evidence was found that significant numbers of drops larger than 100 micro reached the target insects. Because about 95 percent of the spray applied to forests by current methods consist of droplets larger than 50 micro, the biologically effective portion of the drop spectrum is only a few percent. The data foreshadow a major potential reduction in insecticide requirements for the successful control of spruce budworm.


Submaxillary gland of mouse: properties of a purified protein affecting muscle tissue in vitro. A protein from the salivary gland of mice has been highly purified. It affects embryonic muscle tissue in vitro and has both esterase and peptidase activities. Addition of the pure protein to tissue culture in synthetic medium causes dissociation of muscle fibers in individual myoblasts with loss of myosin. This biological activity, as well as the esterase activity, is inhibited by low concentrations of phenylmethanesulfonyl fluoride; this suggests that the effect on the tissue is a consequence of the protein's enzymatic activities.


Glycogen synthetase activity in liver: regulation by the autonomic nerves. Electrical stimulation of the vagus nerve in intact or pancreatectomized rabbits resulted in a marked increase, within 5 minutes of the onset of stimulation, in the total activity of liver glycogen synthetase. The effect was completely counteracted by simultaneous stimulation of the splanchnic nerve, although stimulation of the splanchnic nerve alone had little effect on the enzyme. Injection of insulin caused an increase in both the total activity of glycogen synthetase and the activity that was independent of glucose-6-phosphate. The response of the enzyme to vagal stimulation was much faster than to administration of insulin.


Regulation of body temperature in the blue-tongued lizard. Lizards (Tiliqua scincoides) regulated their internal body temperature by moving back and forth between 15 degrees and 45 degrees C environments to maintain colonic and brain temperatures between 30 degrees and 37 degrees C. A pair of thermodes were implanted across the preoptic region of the brain stem, and a reentrant tube for a thermocouple was implanted in the brain stem. Heating the brain stem to 41 degrees C activated the exit response from the hot environment at a colonic temperature 1 degrees to 2 degrees C lower than normal, whereas cooling the brain stem to 25 degrees C delayed the exit from the hot environment until the colonic temperature was 1 degrees to 2 degrees C higher than normal. The behavioral thermoregulatory responses of this ectotherm appear to be activated by a combination of hypothalamic and other body temperatures.


Visual discrimination of temporal order. Past research addressed to the minimum temporal separation necessary for the judgment of visual stimulus order has failed to control peripheral adaptation and masking effects. The present study employed pairs of brief stimuli with each member presented to a separate eye; that is, dichoptic presentations. Under these conditions, minimum separations for the correct discrimination of order were found to be far less than those obtained in experiments in which both stimuli were presented to the same eye or to both eyes.


Regulation of intracellular sodium concentrations in rat diaphragm muscle. The concept is suggested that the sodium pump mechanism is influenced by the transmembrane electrical potential, and that the pump acts to maintain a constant electrochemical gradient for sodium. Evidence leading to this suggestion was obtained in rat diaphragm muscle by altering systematically the transmembrane chemical gradient for sodium ions and the transmembrane voltage. The voltage changes were produced by varying the extracellular and intracellular potassium ion concentrations. In each case the intracellular sodium concentration changed, presumably by activity of the sodium pump, so that the total electrochemical gradient for sodium was restored.


Biomathematics and computer science.

Biomathematics and computer science.


Light-induced interactions of Rhodospirillum rubrum chromatophores with bromothymol blue.


Studies on the metabolism of adipose tissue. XX. The effect of thyroid status upon oxygen consumption and lipolysis.


Azocarboxypeptidase: functional consequences of tyrosyl and histidyl modification.


Pseudomonas cytochrome c. I. Effect of modification of the amino groups.


Pseudomonas cytochrome c. II. Effect of modification of the methionine residues.


The heterogeneity of the S peptide of bovine pancreatic ribonuclease A.


Binding of proflavine to alpha-chymotrypsin and trypsin and its displacement by avian ovomucoids..


Ultraviolet irradiation effects in poly-L-tyrosine and model compounds. Identification of bityrosine as a photoproduct.


The tritium-hydrogen exchange of myosin and its proteolytic fragments.


The effect of intermediates upon the transport properties of polymerizing systems. I. Monomer, trimer, and nonamer.


The rate of mitochondrial protein synthesis during synchronized division of Astasia.


On the beta configuration of the C-4 methyl in a 4-methyl-delta-8,24-cholestadien-3-beta-ol isolated from rat skin.


The specificity of lincomycin binding to ribosomes.


Heteropolynucleotide synthesis with terminal deoxyribonucleotidyltransferase.


The preparation and properties of some tritiated diazonium salts and related compounds.


Affinity labeling of the active sites of rabbit anti-2,4-dinitrophenyl antibodies with m-nitrobenzenediazonium fluoroborate.


Chemistry and metabolism of sphingolipids. On the biosynthesis of phytosphingosine by yeast.


The binding of divers detergent anions to bovine serum albumin.


Substituents on the alpha-carboxyl group of D-glutamic acid in the peptidoglycan of several bacterial cell walls.


Metastasizing basal-cell carcinoma.

Metastasizing basal-cell carcinoma.


Weber-Christian syndrome of pancreatic origin.


Letterer-Siwe disease.

Letterer-Siwe disease.


Lymphoedema of scrotum--scrotectomy--lymphangiectasia of anogenital region--? Congenital lymphatic deficiency and past filariasis.


Norwegian scabies and lymphatic leukaemia.


Leiomyosarcoma of the skin.

Leiomyosarcoma of the skin.


Nasal skeletal trauma and the interlocked stresses of the nasal septal cartilage.


Experimental peripheral lympho-venous communications.


Correction of maxillary prognathism by one-stage osteectomy.


Plastic reconstruction of the enlarged breast: report of a new technique.


Hypospadias. Some causes of recurrence of ventral curvature of the penis following the straightening procedure.


Advances in the control of infection in burns.


A buoyant head rest.

A buoyant head rest.


A nasal saw of modified design.

A nasal saw of modified design.


A nasal osteotome.

A nasal osteotome.


Mental health services for children.

Mental health services for children.


Rubidomycin in acute leukaemia.

Rubidomycin in acute leukaemia.


New treatments for heroin addiction.

New treatments for heroin addiction.


Insulin antagonism.

Insulin antagonism.


Disturbances of pulmonary function after acute myocardial infarction.


Aversion therapy in management of 43 homosexuals.


Double-blind trial of four hypotensive drugs (methyldopa and three sympatholytic agents).


Total dose imferon (iron-dextran complex) infusion therapy in severe hookworm anaemia.


Results of sympathectomy in digital artery disease.


Choledochoduodenostomy in treatment of chronic pancreatitis and choledocholithiasis.


Red blood cell fragility in multiple sclerosis.


Heterogeneity of the Ehlers-Danlos syndrome: description of three clinical types and a hypothesis to explain the basic defect(s).


Increased fibrinolytic activity in venous blood of hemiplegic limbs.


Paracetamol and the kidney.

Paracetamol and the kidney.


Mental disorder and delinquency.

Mental disorder and delinquency.


Cyclandelate.

Cyclandelate.


A case of thromboembolic pulmonary hypertension. Demonstrated at the Royal Postgraduate Medical School.


Report on the Oxford Accident Service after 25 years.


Varicose veins, oral contraceptives, and thromboembolism.


Chloasma and the contraceptive pill.

Chloasma and the contraceptive pill.


Effects of ouabain, atropine, and ouabain and atropine on A-V nodal conduction in man.


Histochemical and chemical studies of the localization of adrenergic and cholinergic nerves in normal and denervated cat hearts.


Right duct lymph flow in experimental heart failure following acute elevation of left atrial pressure.


Microvascular hypersensitivity subsequent to chemical denervation.


Characterization of the frequency-force relationship in the dog atrium in situ.


Reduction of cardiac tyrosine hydroxylase activity in experimental congestive heart failure. Its role in the depletion of cardiac norepinephrine stores.


Dependence of wall stress in the human thoracic aorta on age and pressure.


Histamine skin sensitivity and blood histamine in patients with urticaria.


The subcellular localization of catecholamines in nerve terminals in smooth muscle tissue.


Effects of bis-(monoisopropylamino)-fluorophosphine oxide (Mipafox) and of starvation on the lipids in the nervous system of the hen.


Protein synthesis and enzymic patterns in the developing brain following head x-irradiation of newborn rats.


Effect of puromycin on the incorporation of radioactive sugars into gangliosides in vivo.


Subcellular distribution of acetyl-CoA synthetase, ATP citrate lyase, citrate synthase, choline acetyltransferase, fumarate hydratase and lactate dehydrogenase in mammalian brain tissue.


Postnatal changes in brain N-acetyl-L-aspartic acid content of normal and hypothyroid suckling rats.


Cholesterol esters in the white matter of adult human brain, serum and cerebrospinal fluid.


Dopamine formation in brain capillaries--an enzymic blood-brain barrier mechanism.


Brain succinate semialdehyde. II. Changes in the developing rat brain.


Brain gamma-aminobutyrate-alpha-oxoglutarate transaminase. II. Activities in twenty-four regions of human brain.


Brain succinate semialdehyde dehydrogenase. 3. Activities in twenty-four regions of human brain.


The effect of cations on the extractability of gangliosides from brain.


Effect of K+-stimulation on GABA metabolism in brain slices in vitro.


Desmosterol in rat brain myelin.

Desmosterol in rat brain myelin.


The distribution of gamma-L-glutamyl-L-glutamine in mammalian tissues.


The influence of combined glycolytic inhibitor, respiratory inhibitor, and protein antagonist on experimental tumor growth.


St. Marys Hospital-Mayo Clinic medical intensive-care unit. I. Organization.


The transfusion of platelet concentrates in patients undergoing heart surgery.


Role of medical history of incentive to scholarship and spur to interdisciplinary research.


The role of medical history in the teaching of medicine.


St. Marys Hospital-Mayo Clinic medical intensive-care unit. II. Patient population.


Temperature regulation in elderly men in bed.


Obstetrics in Western Queensland.

Obstetrics in Western Queensland.


A survey of obstetrics in a single-handed country practice.


Diabetes mellitus and mental illness.

Diabetes mellitus and mental illness.


Placement of suitable psychogeriatric patients in boarding houses.


The emotional problems of undergraduates.


The second observation of haemoglobin Norfolk occurring in an Italian family together with beta-thalassaemia.


McArdle's syndrome.

McArdle's syndrome.


A computer project in clinical immunology.


Ocular side effects of drug therapy.

Ocular side effects of drug therapy.


Modified septal reconstruction for deflected nasal septum.


Giving up cigarettes: 222 case studies.

Giving up cigarettes: 222 case studies.


Acute hepatic coma treated by cross-circulation or exchange transfusion.


Diagnosis and surgical treatment of mitral regurgitation secondary to ruptured chordae tendineae.


Lead in hair of children with chronic lead poisoning.


Rhabdomyoma of the heart. Two unusual clinical presentations.


Diuretics.

Diuretics.


Spontaneous remission of Cushing's disease. Report of a case.


Case records of the Massachusetts General Hospital. Case 18-1967.


Salmonellosis in disseminated malignant diseases. A seven-- year review (1959-1965).


Recovery of pulmonary arterial blood flow in patients with pulmonary embolism.


Reovirus type 3 associated with fatal pneumonia.


Paradox of normal selective coronary arteriograms in patients considered to have unmistakable coronary heart disease.


Injuries in traffic accidents.

Injuries in traffic accidents.


Transthoracic needle biopsy.

Transthoracic needle biopsy.


Hypernatremia complicating sodium sulfate therapy for hypercalcemic crisis.


Case records of the Massachusetts General Hospital. Case 20-1967.


Abdominal herniae and their treatment.

Abdominal herniae and their treatment.


Attempted suicide.

Attempted suicide.


An experiment in teaching; student health visitors.


WRVS in a general hospital.

WRVS in a general hospital.


Royal Cornwall Hospital, Treliske.

Royal Cornwall Hospital, Treliske.


The infection control sister.

The infection control sister.


Nursing with the Nuffield.

Nursing with the Nuffield.


Pain, pains and patients. 4. Age, ache, and penury.


The export of plastic surgical training programs to emerging countries.


Coccidioidomycosis involving head and neck.


The use of the combined palatal pushback and pharyngeal flap operation: a progress report.


Cephalometric evaluation of palatal dysfunction in patients without cleft palate.


Macrodactyly with enlarged median nerve associated with carpal tunnel syndrome.


Self-inflicted injury to the wrist.

Self-inflicted injury to the wrist.


Treatment of macrodactyly.

Treatment of macrodactyly.


Dupuytren's contracture: the value of hypotension in surgical correction.


Surgical tape wound closure: a disenchantment.


Complications in surgery of Dupuytren's contracture.


The effect of several variables on cryoprecipitated factor 8 (AHG) concentrates.


Assay of cardiac lactate dehydrogenase iso-enzymes by means of urea.


The absorption of soluble insulin correlated to the diabetic state.


Phenacetin nephropathy in a mother and daughter.


The Lutheran blood groups: a progress report with observations on the development of the antigens and characteristics of the antibodies.


Disappearance rates of coagulation factors: transfusion studies in factor-deficient patients.


The intravenous tolbutamide test in diagnosing mild and latent diabetes mellitus.


Comparative studies of the viability of human platelets stored at 4 C in plastic and glass containers.


Blood transfusion in the U.S.S.R.: notes on a short visit.


Circulation time determined by decholine. An investigation of the accuracy of the method using I-131.


Trends and present pattern of mortality in chronic uremia.


Concentrated antihemophilic factor (AHF) from outdated blood.


Chromosome studies in pernicious anaemia.


Wegener's granulomatosis. A survey and three cases.


Anticoagulant treatment of the defibrination syndrome.


A simple quality control for the antiglobulin phase of the compatibility test.


A simplified centrifuge for the separation and processing of blood cells.


Studies on fatty acid metabolism in diabetics during exercise. I. Plasma free fatty acid concentration in juvenile, newly diagnosed diabetics during exercise.


Studies on fatty acid metabolism in diabetics during exercise. 3. Individual plasma free fatty acids in newly diagnosed, juvenile diabetics during exercise.


Isolation of human subcutaneous fat cells. Preliminary report.


Application of operant conditioning procedures to the behavior problems of an autistic child: a follow-up and extension.


Therapy of maladaptive fear-motivated behavior in the rat by the systematic gradual withdrawal of a fear-reducing drug.


"Extinction" of a head-bumping symptom of eight years' duration in two minutes: a case report.


Social desirability and sex differences in expressed fear.


Automated self-desensitization: a case report.


Efficacy of "flooding" procedures in desensitization of fear: a theoretical note.


The treatment of hysterical spasmodic torticollis by behaviour therapy.


Establishing functional speech in echolalic children.


A follow-up of alcoholics treated by behaviour therapy.


Experimental studies of "the unconscious": operant conditioning of unconscious eyeblinking.


Overseas students.

Overseas students.


Non-synchronized direct-current countershock in cardiac arrhythmias. One hundred and thirty-two direct-current shocks were administered to 82 patients in an attempt to convert supraventricular tachyarrhythmias. Sinus rhythm was restored in 74 patients. In at least seven instances the shock was delivered during the T wave. Ventricular fibrillation did not occur. One episode of ventricular tachycardia and one of third-degree heart block followed countershock and terminated spontaneously. Excessive digitalis was considered to be a contributing factor in these two arrhythmias. Non-synchronized countershock is considered a safe and effective method of converting atrial fibrillation and flutter.


The importance of monitoring during operations on conjoined twins. Besides complete and careful preoperative investigation of thoracopagus conjoined twins, monitoring of the various parameters, such as arterial blood pressure, central venous pressure, blood pH, and temperature, are most essential for accurate blood replacement, maintenance of normal body chemistry and thermoregulation. Equally important is continued monitoring in the postoperative period when assisted ventilation may be required as well.Twin "A" returned from the operating room in excellent condition, breathing spontaneously through an endotracheal tube. Twin "B" returned on positive-pressure-assisted ventilation; this was to prove a poor prognostic sign as this twin died eight hours postoperatively.


Carcinoma of endometrium and polycystic ovaries in a 22-year-old patient.


Pacemaker-induced repetitive firing: report of two cases.


Raw shellfish and infectious hepatitis.

Raw shellfish and infectious hepatitis.


Adolescent coitus and cervical cancer: associations of related events with increased risk.


Hormones influencing postpartum growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.


Janus green B and the biologic "oxygen effect".


Identification of the route of action of the carcinogen 3:2-dimethyl-4-aminobiphenyl in the induction of intestinal neoplasia.


On the significance and mechanism of the binding of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene to rat-liver ribonucleic acid in vivo.


The effect of x-irradiation on the lysosomes of mouse mammary gland carcinomas.


Electron microscopic and cytogenetic studies of cells derived from Burkitt's lymphoma.


Metabolic characteristics of a naturally occurring preneoplastic tissue. II. Soluble Krebs cycle enzyme activities of hyperplastic alveolar nodule outgrowths and adenocarcinomas of mouse mammary gland.


Cytogenetic studies in multiple myeloma: a study of fourteen cases.


Pulmonary artery occlusion. II. Morphologic studies.


Pulmonary artery occlusion. 3. Biochemical alterations.


Blood O2 content measured with the PO2 electrode: a modification.


Surgical technique in experimental venous admixture.


Inexpensive respiratory sensor constructed from miniature incandescent bulb.


Collection of mouse urine or bile.

Collection of mouse urine or bile.


Evaluation of local tissue blood flow by continuous direct measurement of thermal conductivity.


An isolated, perfused rat brain preparation, its spontaneous and stimulated activity.


Vascular responses to venous congestion.


Role of ventilation in maintaining cardiac output under positive-pressure breathing.


Work and effort.

Work and effort.


Metabolic and circulatory adjustments to unsteady-state exercise.


Physical work capacity of young girls, 7-13 years of age.


Maximum oxygen uptakes of college swimmers.


An analysis of age and other factors related to maximal oxygen uptake.


Local effect of temperature on skin evaporative water loss.


Disturbance of heart rhythm during recovery from exercise in man.


Sinus arrhythmia in man at rest.

Sinus arrhythmia in man at rest.


Surface area of the cat.

Surface area of the cat.


Respiratory and cardiac activity of killer whales.


Oxygen tension gradients in peripheral capillary blood.


Cellular adsorption of pulmonary surface-active material.


Pulmonary artery occlusion. I. Volume-pressure relationships and alveolar bubble stability.


Susceptibility of young leghorn chickens to an ornithosis agent isolated from turkeys.


The effects of actinomycin D on tetanus antitoxin formation in mice.


Serodiagnosis of systemic candidiasis.

Serodiagnosis of systemic candidiasis.


Experimental infection of bats (Tadarida brasiliensis) with Blastomyces dermatitidis.


Radiation response of mammalian tumor cells. I. Repair of sublethal damage in vivo.


Cell proliferation kinetics in the gastrointestinal tract of man. 3. Cell renewal in esophagus, stomach, and jejunum of a patient with treated pernicious anemia.


Chromosomes of tumors induced by 3-methylcholanthrene in the golden hamster.


Prelymphoid leukemia phase of Rauscher virus infection.


Observations on a new virus associated with guinea pig leukemia: preliminary note.


Isolation of cantharidin from Epicauta pestifera.


Kinetic investigation of reversible reaction between methionine and iodine. Improved iodometric determination of methionine.


Coumarins. IV. Coumarins of Pteryxia terebinthina. Structures of two new coumarins, isopteryxin and calipteryxin.


Negative thixotropy in flocculated clay suspensions.


3-cyanopyrrolidines.


Separation and quantitative determination of adrenaline using thin-layer chromatography.


Polymorphism and drug availability. II. Dissolution rate behavior of the polymorphic forms of sulfathiazole and methylprednisolone.


Enzyme inhibitors. XVI. Mode of binding of some 9-(2-hydroxyalkyl)-6-(substituted)purines to adenosine deaminase.


NMR spin-spin decoupling studies of some 5,6-disubstituted bicyclo[2.2.2]oct-2-enes. Assignment of vinylic protons and demonstration of allylic coupling.


Synthesis of tropine-labeled atropine. I. Micro methods for the synthesis of tropine and for its esterification with tropic acid.


Mannich bases from 2-phenylindolizines. I. 3-Alkyl-1-dialkylaminomethyl derivatives.


Variability of uniformity of weight test as an indicator of the amount of active ingredient in tablets.


Mechanism of crystallization of hydrocortisone by ultrasonic irradiation.


Antimalarial agents. IX. 3-Alkylquinolones as potential repository drugs.


Effects of beta-hydroxyethylhydrazine on growth and alkaloid formation of Datura stramonium.


Hepatotoxicity of a series of organotin esters.


Kinetics of aggregation of denatured proteins. I. Methodology based on the multichannel particle size analyzer.


Effect of ultraviolet irradiation on chlorpromazine. II. Anaerobic condition.


Esters of aminoalcohols derived from 3-azabicyclo[3.2.2]nonane.


Determination of chlorobutanol in pharmaceuticals by gas chromatography.


Hydrolysis of Methylparaben.

Hydrolysis of Methylparaben.


Possible ethanol-induced tolerance in rats.


Micelle size and stability of aqueous amphotericin B (polyene) systems.


Isolation and identification of 3 alkaloids from the bark of Zanthoxylum elephantiasis.


Evaluation of antacid activity for metal complexes of tris(hydroxymethyl)aminomethane (THAM).


Catharanthus alkaloids. X. Isolation of lanceine and vinosidine from Catharanthus lanceus roots.


Steric aspects adrenergic drugs. IV. Antagonism of norepinephrine effects by ephedrine isomers on the isolated rabbit ileum.


3-Thenyl nitrogen mustards.

3-Thenyl nitrogen mustards.


Antiradiation compounds. 8. Reaction of thiols with cyanogen bromide.


Paper chromatography study of in vitro and in vivo hydrolysis of heroin in blood.


Tissue levels of chloroamphetamines in rats and mice.


Absorption of ethanol by the common guppy (Lebistes reticulatus).


Potential antiradiation drugs: alpha-alkyloximinonitriles.


New compounds: 3-[2-(2-Chloro-10-phenothiazinyl)ethyl]-3-azabicyclo[3.2.2]nonane.


Rapid method of obtaining the clear aqueous filtrate of an oil-water emulsion.


Intravascular hemolysis with the Gott-Daggett valve.


The effectiveness of various heart-lung machines in the elimination of microbubbles from the circulation.


An effective method of replacing air in the chest with CO2 during open-heart surgery.


The scimitar syndrome. A physiologic explanation for the associated dextroposition of the heart, maldevelopment of the right lung and its artery, and for the systemic collateral supply to the lung.


The prognostic value of the electrocardiographic and vectorcardiographic findings in surgery for aortic regurgitation.


Aneurysm of the pulmonary artery following a Potts' shunt operation. Report of a death from rupture of an aneurysm of the pulmonary artery.


Quantitative evaluation of extracoronary collateral blood flow in the ischemic canine heart. Influence of epicardiectomy and free omental graft.


Cardiac valve replacement for the narcotic addict.


Endocardial radio-frequency pacemaker.

Endocardial radio-frequency pacemaker.


A simple method of producing experimental heart block in dogs.


The influence of diastolic augmentation on infarct size following coronary artery ligation.


Percutaneous needle biopsy of the lung in cases of superior sulcus tumor.


Lymphoma of the lung.

Lymphoma of the lung.


Nontuberculous pulmonary parenchymal conditions predisposing to spontaneous pneumothorax. Report of four cases.


Peptic ulceration and perforation of a left colon bypass for esophageal carcinoma.


Hamartoma of the lung.

Hamartoma of the lung.


Achalasia: dilatation or myotomy?

Achalasia: dilatation or myotomy?


The cause of acute congestive lesions of the lung.


The role of controlled ventilation in the treatment of acute myocardial infarction. An experimental study.


Diastolic augmentation by intra-aortic balloon. Circulatory hemodynamics and treatment of severe, acute left ventricular failure in dogs.


Left atrial myxoma. Diagnosis, treatment, and pre- and postoperative physiological studies.


Injury of the sinus node in open-heart operations.


Unusual aneurysms of the root of the aorta.


Technical considerations for the combined operation of left internal mammary artery or right and left internal mammary implantations with epicardiectomy and free omental graft.


A useful modification of the aortic needle-vent for prevention of air embolism during open-heart surgery.


Severance of mitral prosthesis fixation sutures by annulus calcification.


Congenital mitral stenosis. Report of two cases and a review of the literature.


Unilateral self-retaining retractor for use in internal mammary artery dissection.


The experimental production of chronic mitral valvular obstruction.


Aspergillus aortitis following replacement of aortic valve.


Endvenectomy and decompression in fibrosing mediastinitis causing obstruction of the superior vena cava.


Obstructive lobar emphysema of the newborn infant. Documentation of the "mucus plug syndrome" with successful treatment by bronchotomy.


Fibrinolytic activity in the blood of Nigerian students after four years' residence in the United Kingdom.


Methods in forensic science.

Methods in forensic science.


An automatic dosing apparatus made with standard laboratory ware.


A chromatographic spraying chamber for use with toxic and offensive spray reagents.


Two cardboard boxes adapted for transporting and storing osteological specimens used in gross anatomy laboratory.


An apparatus for the elution of steroids from thin layer chromatograms.


Double standards.

Double standards.


Ultrasonics in molecular research.

Ultrasonics in molecular research.


Peritoneal dialysis.

Peritoneal dialysis.


Pre-discharge ward: a step nearer home.

Pre-discharge ward: a step nearer home.


Nursing research--a reappraisal.

Nursing research--a reappraisal.


A day in the life of a patient (with tongue in cheek of course...).


The growing problem of subnormality. I.

The growing problem of subnormality. I.


Some basic considerations in medical education.


Excitation of nitrogen triplet states by electron impact.


Effect of irradiated sucrose on carbohydrate metabolism of carrot cells.


Irradiation-induced changes in the denaturation temperature and intermolecular cross-linking of tropocollagen.


Sr90-Y90 extracorporeal irradiation in goats and man.


The gross manifestations of continuous gamma irradiation on the prenatal rat.


Age death in Drosophila following sublethal exposure to gamma radiation.


Calibration of the ferrous sulfate dosimeter by ionometric and calorimetric methods for radiations of a wide range of energy.


The effect of prior continuous irradiation on the G2, M, and S phases of proliferating parenchymal cells in the regenerating liver.


Effects of x-irradiation on the hexobarbital-metabolizing enzyme system of rat liver.


Radiation damage to crystalline ribonuclease; identification of the physical alterations by gel filtration on Sephadex.


Delay of fatal pneumonia in x-irradiated mice inoculated with mouse-adapted influenza virus, PR8 strain.


A therapeutic community in the setting of a psychiatric teaching hospital. II. Psychiatric occupational therapy.


Trachoma in Natal and Zululand. II. Severity and some clinical features.


Iatrogenic gynaecological disease.

Iatrogenic gynaecological disease.


Diphenylhydantoin sodium in cardiac arrhythmia.


Recurrent spontaneous pneumothoraces coincident with menstruation.


A new needle adapter for intermittent intravenous therapy.


Inhibition of Rauscher murine leukemia virus growth in vitro by actinomycin D.


A mathematical model for the infectivity-dilution curve of tobacco mosaic virus: theoretical considerations.


A mathematical model for the infectivity-dilution curve of tobacco mosaic virus: experimental tests.


Isolation of "cyanophages" from freshwater ponds and their interaction with Plectonema boryanum.


Induction of DNA nucleotidyltransferase by the Shope fibroma virus.


A quasi-genetic model for plant virus host ranges. II. Differentiation between host ranges.


A quasi-genetic model for plant virus host ranges. 3. Congruence and relatedness.


Localization of wheat streak mosaic virus in the alimentary canal of its vector Aceria tulipae Keifer.


Formation of an infectious nucleoprotein from protein and nucleic acid isolated from a small spherical virus.


Levels of amputation and limiting factors.


Emergency amputations. Lower limb.

Emergency amputations. Lower limb.


Emergency amputations. Upper limb.

Emergency amputations. Upper limb.


Technique of myoplastic amputations.

Technique of myoplastic amputations.


Knee disarticulation and Syme's amputation.


Congenital deformities.

Congenital deformities.


The modern concept of the general management of amputee rehabilitation including immediate post-operative fitting.


Amputees and their prostheses in action.


Early prosthetic rehabilitation.

Early prosthetic rehabilitation.


Bio-engineering aspects of prosthesis design.


Carotid thromboendarterectomy. Technique and results.


Powered arms.

Powered arms.


Significance of outflow obstruction after femoropopliteal endarterectomy.


Infection complicating the use of plastic arterial implants.


Vesicocolic fistula--a complication of colonic cancer. Long-term results of its surgical treatment.


Use of vasopressor agents to increase somatic blood flow.


Toxic megacolon. Significant improvement in surgical management.


Gangrenous extremities resulting from intra-arterial injections.


Thrombosis of axillary and subclavian veins.


Postinfectious intravascular thrombosis with gangrene.


Dextran 40 and dextran 70. A review.

Dextran 40 and dextran 70. A review.


Difficult closures of the duodenal stump.


The recognition of myocardial infarction in the early postoperative period.


The massive bowel resection syndrome. Treatment with reversed intestinal segments.


Complications of small intestinal short-circuiting for obesity.


Obstructing peptic ulcers. Results of treatment.


Surgery for correction of labial angiomas.


Marlex mesh grafts in inguinal hernia repair.


Fibromuscular hyperplasia of the left axillary artery.


Endocytosis in thyroid follicle cells. I. Structure and significance of different types of single membrane-limited vacuoles and bodies.


Subsurface membranes in paired cone photoreceptor inner segments of adult and neonatal Lebistes retinae.


The fine structure of mast cells in normal human gingiva.


A study of nonmyelinated nerves in the rat and rabbit heart.


The arrangement of subunits in flagellar fibers.


The ultrastructure of erythroblastic islands and reticular cells in mouse bone marrow.


Ultrastructure studies of the contraction-relaxation cycle of glycerinated rabbit psoas muscle. I. The ultrastructure of glycerinated fibers contracted by treatment with ATP.


Oral administration of methylene blue to patients with renal calculi.


Prolonged hematuria after renal biopsy.

Prolonged hematuria after renal biopsy.


Late complications of percutaneous renal biopsy.


Kidney size variation during arteriography in hypertensive patients.


Hydatid cysts of the kidney.

Hydatid cysts of the kidney.


Extensive displacement of the kidney by intraperitoneal disease.


Changes in renal function during dreaming sleep.


Periureteritis plastica: report of a case following staphylococcal infection.


Ureteral obstruction: a clinical and laboratory evaluation of the proteolytic enzymes.


Clinical use of long-term indwelling silicone rubber ureteral splints inserted cystoscopically.


Use of silicone rubber in urology.

Use of silicone rubber in urology.


Pitfalls in ureterovesicoplasty for the prevention of reflux.


Cyclophosphamide hemorrhagic cystitis.

Cyclophosphamide hemorrhagic cystitis.


Experience with treatment of 450 cases of bilharzial ulcer of bladder.


Control of bladder tumors by endoscopic surgery.


The treatment of Peyronie's disease by iontophoresis of C21 esterified glucocortocoids.


Epidermoid cysts of the testis.

Epidermoid cysts of the testis.


Metastatic carcinoma of right testicle from primary carcinoma of the appendix.


Perineal extension of adenocarcinoma of the prostate gland after punch biopsy.


Representative causes of ambiguous genitalia.


Office bacteriology.

Office bacteriology.


A simplified urinary collection device.

A simplified urinary collection device.


Evaluation of an autogenous laryngeal papilloma vaccine.


The gamma camera in pediatric urologic diagnosis.


Preservation of the cholesteatoma matrix in the modified radical mastoidectomy.


Meniere's disease--is surgery really necessary?


Tranquilizer prescribing as a function of the experience and availability of the therapist.


Cancer of the larynx. End results report of 106 cases using the clinical staging system.


Operant conditioning in a Vietnamese mental hospital.


Psychopathology and mental retardation.

Psychopathology and mental retardation.


The syndrome of the wrist cutter.

The syndrome of the wrist cutter.


The military psychiatrist as social engineer.


A community project in behalf of the hospitalized mentally ill patient: the cooperative care project.


Response to the presidential address.

Response to the presidential address.


Depression with the use of alpha-methyldopa.


On the experience of nearly dying.

On the experience of nearly dying.


Stages of treatment in the case of a diaper-wearing seventeen-year-old male.


Management of unresolved hypnotic trances as forms of acute psychiatric emergencies.


Cardiovascular actions of angiographic media.


Selective radiopacity in cardiovascular angiography.


The diagnostic scope of catheter angiography.


The role of pulmonary angiography in pulmonary embolism.  A comprehensive review of the roentgen findings.


New techniques in cerebral angiography with particular emphasis on the study of cerebrovascular disease.


Newer techniques in the study of the pulmonary circulation.


Initial serological reactions in infectious syphilis.


Incidence of reactive VDRL tests in the normal rabbit.


An analysis of some characteristics of males with gonorrhoea.


Oral chloramphenicol alone and with intramuscular procaine penicillin in the treatment of gonorrhoea.


Primary and secondary syphilis. Country of origin study, 1965.


Arthritis and genital infection in paraplegic patients.


Arrhythmias after myocardial infarction.


Pregnancy in the adolescent.

Pregnancy in the adolescent.


Orthopaedic surgery in spastic paralysis.


Rheumatic fever and streptococcal infection.


Carcinoma of hypopharynx and cervical oesophagus.


Assessment of arrhythmias in myocardial infarction.


Obstetrical implications of pregnancy in primigravidae aged 16 years or less.


Annual incidence, prevalence, and mortality of multiple sclerosis in white South-African-born and in white immigrants to South Africa.


Renal failure after cholangiography.

Renal failure after cholangiography.


Plasma salicylate levels in acute poisoning in adults.


Singledose dexamethasone suppression test for Cushing's Syndrome.


Intracranial hypertension in a child during treatment with nalidixic acid.


Spironolactone.

Spironolactone.


A health week in rural general practice.


"Cruachan"--a home for children with metabolic needs.


Treatment of osteoporosis.

Treatment of osteoporosis.


Opinion: revision in diploma schools of nursing.


Ingrowing toenails.

Ingrowing toenails.


Remotivation to motivation.

Remotivation to motivation.


Hemophilia.

Hemophilia.


The nurse and the hemophiliac patient.

The nurse and the hemophiliac patient.


Prostheses for cancer patients.

Prostheses for cancer patients.


Programmed instruction--can we use it?

Programmed instruction--can we use it?


Sex knowledge of prospective teachers and graduate nurses.


Supracondylar fracture of the adult femur. A study of one hundred and ten cases.


Idiopathic osteo-arthritis of the hip. Comparison of the results of treatment by Austin Moore prosthesis and mold arthroplasty.


The treatment of pyogenic bone and joint infections by closed irrigation (circulation) with a non-toxic detergent and one or more antibiotics.


A simple anteromedial approach to the lesser trochanter of the femur for the release of the iliopsoas tendon.


Transfer of the brachioradialis to improve wrist extension in high spinal-cord injury.


Isolated injury to the median nerve above the elbow. A review of thirteen cases.


Tenolysis in the hand and wrist. A clinical evaluation of two hundred and twenty flexor and extensor tenolyses.


Iron uptake by bone. Its relation to calcium ion concentration.


Intraosseous vertebral venography as a diagnostic aid in evaluating intervertebral-disc disease of the lumbar spine.


Typhoid osteomyelitis of the calcaneus due to direct inoculation.


Tumoral calcinosis. A report of six cases.


Median neuropathy in the carpal tunnel caused by tumor-like conditions. Report of two cases.


Varix involving the tibia.

Varix involving the tibia.


Etiology of shoulder injuries in athletes.


Fractures and ligamentous injuries of the clavicle and its articulation.


Nerve injuries about the shoulder in sports.


Sensory stimulation and the treatment of senile dementia.


Nasal trauma. 2. The management of established post-traumatic deformities.


Blood pressures in Melanesians.

Blood pressures in Melanesians.


Chlorinated hydrocarbon residues in human body fat.


A survey of human sera in Sydney for antibodies to Mycoplasma pneumoniae (Eaton agent).


British medicine and the Common market.

British medicine and the Common market.


Social problems arising in relation to premarital intercourse.


The natural history of intracranial aneurysms.


Unusual arrhythmias after corrective surgery for transposition of the great vessels.


Methods and physical characteristics of the kinetocardiographic and apexcardiographic systems for recording low-frequency precordial motion.


Observations on sustained pulsus alternans during hypothermia.


Control of recurrent ventricular fibrillation by transvenous pacing in the absence of heart block.


Emergency replacement of valves in endocarditis.


Clinical pathologic conference.

Clinical pathologic conference.


The nature of the increased vascular resistance in chronic hypertension.


Determination of glomerular filtration rate with 57Co-B12 measurement of protein binding.


Antibiotic persistence during renal failure and dialysis.


Cardiogenic shock treated with infusion of dextrose solution.


Measurement of anti-arrhythmic potency of drugs in man: effects of dehydrobenzperidol.


The metabolism and elimination of d-tubocurarine-H3.


Nitrous oxide inhibition of sodium transport.


Clinical studies on succinylcholine chloride.


Neuromuscular effects of d-tubocurarine, edrophonium and neostigmine in man.


Effect of subanesthetic concentrations of halothane and methoxyflurane on pain threshold in conscious volunteers.


Progressive myoclonus epilepsy with Lafora inclusion bodies. I. Clinical, genetic, histopathologic, and biochemical aspects.


Effects of calcium and cylopropane on Purkinje fibers.


Progressive myoclonus epilepsy with Lafora inclusion bodies. II. Studies of ultrastructure.


Confirmation of atypical parasympathetic innervation of the parotid gland. Atypical distribution of ninth nerve.


Effects of hyperventilation on the rate of cerebral anesthetic equilibration. Calculations using a mathematical model.


Measurement of a spinal reflex response (H-reflex) during general anesthesia in man. Association between reflex depression and muscular relaxation.


Dyspraxia following division of the cerebral commissures.


Hereditary mirror movements.

Hereditary mirror movements.


Effect of changes in blood volume on body impedance.


Peripheral nerve glycolysis in Wallerian degeneration.


The gas chromatographic determination of mepivacaine in blood with a note on other local anesthetics.


Synergistic effect of cyclopropane and epinephrine on sodium transport in toad bladder.


Electrodiagnostic aspects of the carpal tunnel syndrome.


The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.


Clinical studies with Innovar.

Clinical studies with Innovar.


Mycosis fungoides involving the brain.

Mycosis fungoides involving the brain.


Laryngeal band: possible relation to prolonged naso-tracheal intubation.


The fine structural arrangement of the cortex.


A mechanical aid for positioning psychiatric patients for spinal and epidural anesthesia.


An effective method for the treatment of hiccups during anesthesia.


"Internal" feedback mechanism: response of pituitary FSH and of stalk-median eminence follicle stimulating hormone-releasing factor to median eminence implants of FSH.


Studies on the mechanism of nidation. XXV. A receptor theory for induction of decidualization.


Succinylcholine danger in the burned patient.


Induction of lactation by ovariectomy of pregnant rats.


Metabolism of collagen in experimental hyperthyroidism and hypothyroidism in the rat.


Acute effects of hydrocortisone on gluconeogenesis from 14C- and 3H-labeled substrates in intact rats.


Influence of neonatal hypothyroidism and of thyroxine on the acetylcholinesterase and cholinesterase activities in the developing central nervous system of the rat.


Factors affecting uptake of estradiol-6,7-3H by the hypophysis and hypothalamus.


TSH stimulation of 14C-amino acid incorporation into protein by isolated bovine thyroid cells.


Steroid structural requirements for mammary gland differentiation in vitro.


Thyroxine-like actions of 3'-isopropyl-3,5-dibromo-L-thyronine, a potent iodine-free analog.


Effect of muscular exercise on adrenal 17-hydroxycorticosteroid secretion in the dog.


Metabolism of estrogens in rat adipose tissue.


Quantitative variations in total and soluble collagen in testes of prepubertal and adult rats.


Sensitivity to ADH of normal and diabetes insipidus rats.


Dose-response relationships between hypothalamic PIF and prolactin release by rat pituitary tissue in vitro.


Further studies on species differences in follicle stimulating hormone as revealed by the slope in the Steelman-Pohley assay.


Effect of extracorporeal circulation and deep hypothermia on adrenocortical secretion.


Effects of puromycin and actinomycin in vitro on sulfate incorporation by cartilage of the rat and its stimulation by serum sulfation factor and insulin.


Fatty acid transport and incorporation into human erythrocytes in vitro. When human erythrocytes were incubated in vitro with (14)C-labeled free fatty acids bound to serum albumin, labeled fatty acids were incorporated into erythrocyte triglycerides and phospholipids. The first step in this reaction was the transfer of free fatty acids from the albumin to the cells. This transfer was rapid and reversible. The acids were distributed between albumin and cells according to the relative quantities of albumin and cells present. Each acid had a different distribution coefficient. At equilibrium, relatively larger fractions of the stearic and palmitic acids and smaller fractions of the oleic and linoleic were associated with the cells. All these fatty acids were then slowly incorporated into phospholipids and triglycerides. The rate of incorporation of each was a function of its concentration in the cells, but larger fractions of the oleic and linoleic were incorporated than of the stearic, palmitic, myristic, or lauric. The two processes of transfer and incorporation thus had almost opposite selectivities for the different fatty acids. As a result, the fatty acids incorporated into triglycerides and phospholipids resembled in composition the fatty acids on the albumin except for moderately less stearic acid.


Proceedings of the fifty-ninth annual meeting of the American Society for Clinical Investigation, Inc., held in Atlantic City, N. J., May 1, 1967. Presidential address. The mores of clinical investigation.


Diffusion of glucose, insulin, inulin, and Evans blue protein into thoracic duct lymph of man. Immunoreactive insulin, like inulin, quickly equilibrates with interstitial fluid, as evidenced by recovery in thoracic duct lymph in man. Insulin-like activity not accounted for by immunoreactive insulin behaves as a large protein and is confined to the vascular compartment.


The renal handling of insulin.

The renal handling of insulin. The renal handling of insulin was studied by insulin immunoassay in arterial blood, renal venous blood, and urine of fasting patients with normal renal function and in peripheral venous blood and urine of normal subjects and patients with renal disease before and after an oral glucose load. A renal arteriovenous insulin concentration difference of approximately 29% was found and suggests that in normal subjects renal insulin clearance is significantly in excess of glomerular filtration rate. The insulin excreted in the urine of normal individuals at no time exceeded 1.5% of the load filtered at the glomerulus. This contrasts with the finding of a urinary insulin clearance approaching glomerular filtration rate in patients with severely impaired renal tubular function. It is suggested that insulin is normally filtered at the glomerulus and then almost completely reabsorbed or destroyed in the proximal tubule. If reabsorption occurs, as seems more likely, reabsorbed insulin does not return to the renal vein and is presumably utilized in renal metabolism together with insulin taken up directly from the blood. Caution is advised in the use of urinary insulin concentration or excretion as an index of serum insulin level or insulin secretion because a very small and variable proportion of filtered insulin appears in the urine in normal subjects, and major changes in urinary insulin excretion may arise as a result of minor tubular defects.


Measurement of intracellular pH of skeletal muscle with pH-sensitive glass microelectrodes. We used three methods to examine the relationship among intracellular pH, transmembrane potential, and extracellular pH. Single-barreled electrodes permitted the determination of resting potential and intracellular pH with a minimum of cellular injury. Double-barreled electrodes, which incorporated a reference as well as a pH-sensitive electrode in a single tip, facilitated the direct measurement of intracellular pH without the interposition of the transmembrane potential. Triple-barreled electrodes permitted measurement of intracellular pH during the controlled hyperpolarization or depolarization of the cell membrane. The results of all three methods were in close agreement and disclosed that the H(+) activity of intracellular and extracellular fluid is in electrochemical equilibrium at any given transmembrane potential. This implies that the determinants of intracellular pH are the transmembrane potential and the blood pH. The actual pH of the normal resting muscle cell is 5.99, as estimated from the normal transmembrane potential and blood pH, or as determined by direct measurements of intracellular pH.


Pulmonary mechanics during pregnancy.

Pulmonary mechanics during pregnancy. Previously reported changes in static lung volumes during pregnancy have been confirmed. Measurements of lung compliance (C(L)) and total pulmonary resistance (R(L)) were made in 10 women in the last trimester of pregnancy and 2 months postpartum, employing an esophageal balloon and recording spirometer. C(L) was unaffected by pregnancy, but R(L) was 50% below normal during pregnancy. Measurements of airway conductance (C(A)) were made, employing the constant pressure body plethysmograph on 14 nonpregnant and 13 pregnant women. Specific airway conductance was increased during pregnancy. Serial measurements of C(A) indicated a progressive increase beginning at about 6 months of gestation and a return to normal by 2 months postpartum. The mechanism of the increased C(A) during pregnancy is not known. It may be related to changes in bronchial smooth muscle tone and conceivably explains the tolerance of certain patients with lung resections to pregnancy.


Estimation of the secretion rate of thyrotropin in man. The plasma concentration of a pituitary hormone is determined by the rate of secretion, degradation, and the volume of distribution of that hormone. Using a radioimmunoassay for human thyrotropin (TSH) and human TSH-(131)I, we have estimated the rates of degradation and distribution of TSH in man and calculated the rate of secretion. Either 0.5 or 5 mug of TSH-(131)I with specific activities of 1 to 50 muc per mug was administered intravenously to 12 euthyroid subjects. Serial determinations were made of TSH-(131)I, and the half-time of disappearance (t((1/2))) was thus estimated. The average t((1/2)) in euthyroid subjects was 53.9 minutes with a volume of distribution averaging 5.8% of body weight. The mean endogenous plasma TSH concentration was 1.8 mmug per ml (2.7 muU per ml in terms of the human TSH reference standard A). The mean total TSH pool, excluding the pituitary, was 5.8 mug (8.7 mU). From these data the mean secretion rate of TSH in euthyroid man was calculated to be 110.1 mug per day (165.2 mU). Similar data were estimated for 3 mildly hypothyroid patients. The t((1/2)) were 75.1, 97.1, and 83.6 minutes, with a mean of 85.3 minutes (1.6 times normal). The mean TSH pool was 58.1 mug (10 times normal). The secretion rate was 688.7 mug per day (1,033.1 mU). In other hypothyroid patients, plasma TSH levels ranging from 6 to 230 mmug per ml (9 to 345 muU) have been found. If similar half-times and a normal distribution volume are assumed, the secretion rate of TSH in hypothyroid patients can be estimated to range from about 260 to 15,350 mug per day (390 to 23,025 mU) or from about 2 to 307 times normal. Therefore, the elevated plasma TSH levels found in hypothyroidism are a result of both slower degradation and increase in rate of secretion.


The metabolism and secretion of aldosterone in elderly subjects. The secretion rates [34 +/- 6 (SE) mug per day, 9 subjects] and metabolic clearance rates (MCR) [1,288 +/- 120 (SE) L of plasma per day, 9 subjects] of aldosterone in elderly subjects are significantly lower than those of young subjects [77 +/- 7 (SE) mug per day and 1,631 +/- 106 (SE) L per day, respectively]. There is a correlation of the MCR and secretion rate values (p = 0.02), but the calculated plasma concentrations (secretion rate/MCR) are also significantly low in the elderly subjects [2.6 +/- 0.3 (SE) compared with concentrations in the plasma from young subjects of 4.7 +/- 0.6 (SE) mug per 100 ml plasma]. The urinary excretion of radioactivity from oral and intravenously administered labeled aldosterone as aldosterone in the neutral extract, as aldosterone released by acid hydrolysis, and as tetrahydroaldosterone released by incubation with beta-glucuronidase is generally similar for young and elderly subjects except that a larger portion of the oral compared with the intravenous dose is excreted as free aldosterone in the elderly subjects, indicating that the splanchnic extraction is reduced. The calculated splanchnic blood flow (assuming no alteration in extrasplanchnic metabolism) is also slightly lowered. Therefore, as in patients with mild cardiac dysfunction, the lowered MCR of subjects is due to both reduced splanchnic extraction and blood flow. However, unlike the heart failure patients, in the elderly subjects the plasma concentration of aldosterone is also reduced.


Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build. The turnover rate of plasma total esterified cholesterol was measured after the intravenous injection of tritiated mevalonic acid in 16 men with coronary heart disease. Four subjects were normocholesterolemic and 12 were hypercholesterolemic; among the latter, 3 suffered from familial hypercholesterolemia and 6 were overweight. The turnover rate of plasma esterified cholesterol was highest among the overweight hypercholesterolemic subjects and least among the subjects with familial hypercholesterolemia. Hypercholesterolemic subjects of normal weight had turnover rates similar to those found in normocholesterolemic men. Significant correlations were found between body surface or body weight and the turnover rate of plasma esterified cholesterol. We conclude that the factors which determine the development of hypercholesterolemia are not identical in all hypercholesterolemic subjects and that when hypercholesterolemia is associated with overweight there is an increased formation of at least plasma esterified cholesterol.


Renal clearance of cystathionine in homozygous and heterozygous cystathioninuria, cystinuria, and the normal state. Cystathionine is more readily cleared from the plasma than other amino acids. This is because the amino acid has a very low tubular maximum (Tm), in the order of 1 mumole per minute per 1.73 square meters body surface area (BSA). No essential differences in the reabsorption of cystathionine were observed in four normal subjects, two patients with homozygous cystathioninuria, one patient with heterozygous cystathioninuria, and one patient with cystinuria. Apparent net tubular secretion of cystathionine was demonstrated in a child with homozygous cystathioninuria only after an intravenously administered load of lysine.


Hyperplastic and early neoplastic lesions of the liver in Buffalo strain rats of various ages given subcutaneous carbon tetrachloride.


Ceruloplasmin in Wilson's disease.

Ceruloplasmin in Wilson's disease. Ceruloplasmin was highly purified from one patient with Wilson's disease and partially purified from a second unrelated patient. The highly purified ceruloplasmin was indistinguishable from normal ceruloplasmin by electrophoresis, tryptic peptide map, oxidase activity, and copper, amino acid, and sugar composition. The partially purified ceruloplasmin was indistinguishable electrophoretically from normal ceruloplasmin. With penicillamine therapy, ceruloplasmin disappeared from the serum of the first patient; it reappeared after the drug was discontinued. The significance of this observation in regard to the basic defect in Wilson's disease is discussed.


Poorly differentiated cholangiocarcinomas occurring "spontaneously" in C3H and C3H x Y hybrid mice.


Comparison of the carcinogenic actions of subcutaneous implants of iron and aluminum in rodents.


Gastric ulceration in tumor-bearing rats.


Virus particles associated with strain 2 guinea pig leukemia (L2C/N-B).


Levels of 3-methylcholanthrene and 7, 12-dimethylbenz[alpha]anthracene in rat mammary fat pads after intragastric administration, and relationships to carcinogenic response.


Clinical pathological conference. The Children's Hospital Medical Center, Boston, Mass.


Mode of development of cleft lip.

Mode of development of cleft lip.


Complication resulting from an intramuscular injection.


The question of sex hormone therapy in cases of delayed puberty.


Longitudinal studies of acid-base status in infants with low birth weight.


Monarticular juvenile rheumatoid arthritis.


Defective thirst mechanism secondary to a hypothalamic lesion: studies in a child with adipsia, polyphagia, obesity, and persistent hyperosmolality.


A human ring D chromosome associated with multiple congenital abnormalities.


Heritable dysmorphic syndrome with normal intelligence.


Seasonal variation of congenital hypertrophic pyloric stenosis.


Enuresis and nocturia in sickle cell disease.


Effect of trace elements in drinking water on dental caries.


Effect of pasteurisation on the chemical composition of liquid whole egg. I. Development of a scheme for the fractionation of the proteins of whole egg.


The purpose and work of geriatric day hospitals.


When caring for the seriously injured.

When caring for the seriously injured.


Rubella. 2.

Rubella. 2.


Foresterhill College, Aberdeen.

Foresterhill College, Aberdeen.


Pictorial paediatrics. 3. Odd faces.

Pictorial paediatrics. 3. Odd faces.


Medical records.

Medical records.


Outpatient nursing; sisters' views.

Outpatient nursing; sisters' views.


Big money for nurses?

Big money for nurses?


Why not nursing?

Why not nursing?


Stress ulcers: a survey of the experience in a large general hospital.


The role of vagotomy in duodenal ulcer surgery.


Hemodynamic state early after replacement of aortic valve with ball-valve prosthesis.


Functional circulatory disorders of lower extremities due to regional hemokinetic imbalance: a new clinical and angiographic concept.


An experimental study of venous hemostasis.


Antibody production in mice after thermal and tourniquet trauma.


The toxicity of alkyl 2-cyanoacrylate tissue adhesives: brain and blood vessels.


Effects of electrical stimulation of the carotid sinus nerve in reversal of experimentally induced hypertension.


Treatment of experimental shock: comparison of the effects of norepinephrine, dibenzyline, dextran, whole blood, and balanced saline solutions.


Prolonged cross-circulation for reversible pulmonary failure.


Colonic reconstruction of the esophagus in infants and children.


Clinically unrecognized myocardial infarction in the Western Collaborative Group Study.


Recurring and fatal myocardial infarction in the Western Collaborative Group Study.


Detection of coronary-prone subjects in a normal population by radioelectrocardiographic exercise test. Follow-up studies.


"Mapping" the precordium. I. Heart sounds of normal subjects.


Experimental production of intracavity pressure differences. Possible significance in the interpretation of human hemodynamic studies.


Design of a centralized electrocardiographic and vectorcardiographic system.


A computer program for the peripheral pulse wave.


Rapidly progressing pulmonary vascular obstructive disease. Association with ventricular septal defects during early childhood.


Sickle cell states and cardiomyopathy. Sudden death due to pulmonary thrombosis and infarction.


Unilateral chronic pulmonary edema and pleural effusion after systemic-pulmonary artery shunts for cyanotic congenital heart disease.


Normal splitting of the second heart sound in atrial septal defect.


The systolic murmur of combined pulmonary stenosis and infundibular stenosis.


Supernormal phase of atrioventricular conduction. Association with second degree ventricular-ectopic block.


Location of the pre-excitation areas in the Wolff-Parkinson-White syndrome.


The relation of the clinical investigator to the patient, pharmaceutical industry and federal agencies.


Effect of intravenous aminophylline on distribution of pulmonary blood flow in obstructive lung disease.


Exercise and intrapulmonary ventilation-perfusion relationships in chronic obstructive airway disease.


Studies of pulmonary function in patients with Schistosomiasis mansoni.


Differential identification of mycobacteria. II. Subgroups of Groups II and 3 (Runyon) with different clinical significance.


Psychotoxic reaction during ethionamide therapy.


A re-evaluation of normal pulmonary function measurements in the adult female.


A controlled trial of community-wide isoniazid prophylaxis in Alaska.


An epidemic of respiratory infection due to Mycoplasma pneumoniae in a civilian population.


Massive venous thrombosis and carcinoma of the lung.


The quantitative measurement of emphysema using diazo replication and the particle analyzer.


Spinal cord changes in familial dysautonomia.


Fibrin promotion and lysis in arthritic joints.


The electroencephalogram in hypercalcemia.


Sylvian seizures and midtemporal spike foci in children.


"Centrencephalic" seizure discharges in focal hemispheral lesions.


Monomelic myopathy. Congenital hypertrophic myotonic myopathy limited to one extremity.


Transient recurring paralysis of ocular abduction. A syndrome of intracranial hypertension.


The serial sevens subtraction test.

The serial sevens subtraction test.


Intracranial chordoma in children.

Intracranial chordoma in children.


Cryosurgery in ophthalmology.

Cryosurgery in ophthalmology.


Macular disease and amblyopia. The visual-evoked response.


Electro-oculography in vitelliform degeneration of the macula.


Mydriatic effect of four drugs determined with pupillograph.


Inheritance of dexamethasone hypertension and glaucoma.


Ratio of accommodative convergence to accommodation. Accommodative strabismus.


Acquired superior oblique palsy. Diagnosis and management.


Conjunctival dehiscence and atrophy of orbital fat. Complication of scleral buckling operation.


Peripheral cystoid degeneration of the retina. Incidence and distribution in 1,000 autopsy eyes.


Grid for scoring visual fields. I. Tangent screen.


AC:A nomogram.

AC:A nomogram.


Intraocular manifestations of multiple myeloma.


Congenital teratoma of the orbit.

Congenital teratoma of the orbit.


Pancreatic carcinoma with metastasis to the optic nerve.


Symposium on safe surgery. The maintenance of homeostasis. Surgical nutrition.


Mechanisms of host response in the eye. 3. Interocular protein transfer.


Clinical aspects of supportive perfusion.


Symposium on safe surgery. Circulatory and respiratory problems. Respiratory support.


Effect of flow and pressure on pulmonary vessels. A semiquantitative study based on lung biopsies.


Further observations on the effect of hydrogen ion on the pulmonary circulation.


Characterization of the circulatory response to maximal upright exercise in normal subjects and patients with heart disease.


Relation of heart rate and systolic blood pressure to the onset of pain in angina pectoris.


Use of ultrasound to measure left ventricular stroke volume.


Hemodynamic studies in cardiogenic shock. Treatment with isoproterenol and metaraminol.


Clinical sequelae from arterial needle puncture, cannulation, and incision.


The Frank vectorcardiogram and the electrocardiogram in Duchenne progressive muscular dystrophy.


Intrapulmonary segment in anomalous pulmonary venous connection. Resemblance to scimitar syndrome.


Reciprocal beating from artificial ventricular pacemaker. Report of a case.


Warts.

Warts.


Adolescents and summer accidents.

Adolescents and summer accidents.


Warning regarding administration of fluids.


Intrauterine contraceptive devices.

Intrauterine contraceptive devices.


Obesity in childhood.

Obesity in childhood.


Serologic tests in relation to prenatal and postnatal diagnosis of hemolytic disease of the newborn.


Counselling the parents of the mentally handicapped child.


Pediatric gynecologic conditions: a series of short discussions.


Therapy of diarrheal disease in early childhood. Principles based on observations in the tropics.


Bromide intoxication in infants.

Bromide intoxication in infants.


Clinical Rounds from the Massachusetts General Hospital. Ketotic hypoglycemia, an important cause of seizures.


Hand, foot, and mouth disease. A clinically recognizable virus infection seen mainly in children.


The World Health Organization. A description and appraisal.


The unmet needs of children.

The unmet needs of children.


Importance of low shear rate blood viscometry in extracorporeal circulation.


Phospholipids of Trypanosoma lewisi, T. vivax, T. congolense, and T. brucei.


Comparison of reactions of human antisera in the methylene blue dye test for toxoplasmosis using bioassay procedures.


Respiratory changes accompanying Leishmania to leptomonad transformation in Leishmania donovani.


Effects of limb disability on lousiness in mice. IV. Evidence of genetic factors in susceptibility to Polyplax serrata.


Comparison of hemoglobins of Fasciola gigantica (Trematoda: Digenea) and its host.


Pathologic physiology and chemotherapy of Plasmodium berghei. I. Suppression of parasitemia by sulfones and sulfonamides in mice.


Studies on the oxidation-reduction potentials of heme proteins. VI. Human hemoglobin treated with various sulfhydryl reagents.


Incorporation of 35SO4 into endogenous heparin by a microsomal fraction from mast cell tumors.


Mammalian liver glycogen synthetase. Altered primer requirements in the presence of glucose 6-phosphate or orthophosphate.


Glycogen synthetase of bee larvae.

Glycogen synthetase of bee larvae.


The formation of diiodotyrosine in iodinated human serum albumin.


Physiological processes and dynamics in the disposition of small and large doses of biologically active and inactive 131-I-insulins in the rat.


The properties of thyroglobulin. XV. The function of the protein in the control of diiodotyrosine synthesis.


A method for the quantitative modification and estimation of carboxylic acid groups in proteins.


Multiple molecular forms of bovine heart cytochrome c. V. A comparative study of their physicochemical properties and their reactions in biological systems.


Optically active absorption bands of hemoglobin and its subunits.


Inhibition of beta-glucuronidase by cholesterol and retinol.


Peroxidase isozymes from horseradish roots. II. Catalytic properties.


Electron carries for the phosphoroclastic reaction of Desulfovibrio desulfuricans.


Esterase and clotting activities derived from citrate activation of human prothrombin.


An improved purification, crystallization, and some properties of rabbit muscle 5'-adenylic acid deaminase.


Purification and properties of human transferrin C and a slow moving genetic variant.


A study of the cooper content of beta-mercaptopyruvate trans-sulfurase.


Optical rotatory dispersion of aldolase and glyceraldehyde 3-phosphate dehydrogenase.


The involvement of the amino-terminal amino acid in the activity of pancreatic proteases. I. The effects of nitrous acid on elastase.


The involvement of the amino-terminal amino acid in the activity of pancreatic proteases. II. The effects of nitrous acid on trypsin.


The structure of goat hemoglobins. I. Structural studies of the beta chains of the hemoglobins of normal and anemic goats.


Accumulation of tricarboxylic acids related to lysine biosynthesis in a yeast mutant.


The isolation of identical hydroxylysyl glycosides from hydrolysates of soluble collagen and from human urine.


Evidence for an oxygenated intermediate in the tryptophan pyrrolase reaction.


A comparison of certain properties of catechol-O-methyl transferase to those of adrenergic beta receptors.


Agonist-antagonist interactions in the normal and supersensitive nictitating membrane of the spinal cat.


The stimulation of canine prostatic secretion by sympathomimetic amines.


Structure-activity relationships among a series of acetylenic carbamates related to McN-A343.


Quantitative aspects of the replacement of norepinephrine by dopamine as a sympathetic transmitter after inhibition of dopamine-beta-hydroxylase by disulfiram.


Release of intestinal 5-hydroxytryptamine by morphine and related agents.


Relationship between hypothalamic catecholamines and gonadotrophin secretion in rats.


Inhibition of gluconeogenesis by hydrazine administration in rats.


Pharmacokinetics of salicylamide elimination in man.


Effects of dopamine and alpha-methyl-dopamine on smooth muscle and on the cardiac pacemaker.


The effect of stress upon the performance of the amine-depleted heart.


Cardiovascular and myocardial metabolic effects of infusions of phenylephrine.


Reactivation by pyridinium aldoxime methochloride (PAM) of inhibited cholinesterase activity in dogs after poisoning with pinacolyl methylphosphonofluoridate (soman).


Malathion inhibition of esterases as a determinant of malathion toxicity.


The use of a clinical whole-body counter in long-term exchangeable sodium studies for the comparison of the effect of different diuretics.


Chlorothiazide-induced kaliuresis after adrenalectomy.


The anticonvulsant action of inhibitors of carbonic anhydrase: site and mode of action in rats and mice.


Relation of chlorpromazine-evoked hypothermia to disruption of conditioned avoidance-escape behavior.


Variations in the course of the facial nerve as illustrated by tomography.


Diagnostic correlates in fenestral otosclerosis.


Chondrosarcoma of the larynx.

Chondrosarcoma of the larynx.


Post-laryngectomy care in the Middle Western United States.


Tonal patterns of cochlear impairment following intense stimulation with pure tones.


The standardization of bone-conduction thresholds.


Acoustically-evoked potentials in man: mediation of early components.


Perilymph fistula in stapes surgery.

Perilymph fistula in stapes surgery.


Arterial perfusion of the inner ear. Evaluation of different perfusion media. (With motion picture).


Radioisotope scanning of the salivary glands. A preliminary report.


Non-traumatic aseptic necrosis of the femoral head.


Neurogenic heterotopic ossification.

Neurogenic heterotopic ossification.


The fractured scaphoid: a modern view.

The fractured scaphoid: a modern view.


Glomerulonephritis in the territory of Papua-New Guinea: a preliminary report based on a necropsy study.


Severe incompatible transfusion reaction without demonstrable antibodies.


Traffic accidents: a comprehensive Australian study.


Children of phenylketonuric mothers.

Children of phenylketonuric mothers.


Radioisotopes in medicine. 2. The localization of space-occupying lesions.


A medical and sociologic study of the unwed mother. I. Background and medical care.


Nonunion of pathologic fracture after radiation therapy.


The three E's of the occupational nurse:  education--experience--economics.


From the Crimea to the planets.

From the Crimea to the planets.


Occupational health nursing in the Dallas area.


A need, a goal, a joint project.

A need, a goal, a joint project.


Medical electronics in our future.

Medical electronics in our future.


A study of disillusionment: depressive reactions of Liberian students returning from advanced training abroad.


Some observation on the viscosity of blood in various diseases. Effect of intravenous heparin.


Women in medicine.

Women in medicine.


Permanent endocardial pacing in complete heart block. Assessment of the technique and the advantages in 20 patients.


Management of sclerosing fibrosis of the mediastinal and retroperitoneal areas.


Cervicothoracic sympathectomy in neurovascular abnormalities of the upper extremities: experiences in 76 patients with 104 sympathectomies.


Carotid body tumors.

Carotid body tumors.


Vagotomy and pyloroplasty in the management of hiatal hernia.


Circumferential small bowel ulcers: a report of nine cases.


Penetrating wounds of the abdomen: analysis of 776 operative cases.


The pathology of peritoneal repair: its relation to the formation of adhesions.


Reappraisal of open intestinal anastomoses.


Management of chronic hyperchloremic acidosis.


Single-layer open gastrointestinal anastomosis.


Benign gastric ulcer with life-threatening hemorrhage.


Anastomotic ulcers.

Anastomotic ulcers.


Surgical correction of facial paralysis: a plea for better reconstructions.


Limits of non-colloid solution replacement in experimental hemorrhagic shock.


Red cell life span in iron deficiency anaemia.


The natural history of lymph node-to-vein anastomoses.


Atypical hereditary spherocytosis: biochemical studies and sites of erythrocyte destruction.


Malignant retroperitoneal fibrosis.

Malignant retroperitoneal fibrosis.


Arterial perfusion of the breast with cytotoxic drugs.


Non-malignant retroperitoneal fibrosis.

Non-malignant retroperitoneal fibrosis.


Acanthosis nigricans.

Acanthosis nigricans.


Femoral vein pressures in post-phlebitic iliac vein obstruction.


Experimental arterial patching using veins and other autologous tissues.


Hyperparathyroid crisis.

Hyperparathyroid crisis.


Colonic replacement after pharyngolaryngectomy.


Differential systemic and visceral cooling through peritoneal circulation.


Solitary ulcers and diverticulitis of the caecum.


Ninety-two cases of ileosigmoid knotting in Uganda.


Successful amputation through the hip for pseudotumour in severe haemophilia.


Intraluminal obstruction of the femoral vein by an angiomatous malformation.


Absorption of toxic drugs from burns.

Absorption of toxic drugs from burns.


The biopharmaceutical properties of solid dosage forms. I. An evaluation of 23 brands of phenylbutazone tablets. The potency, disintegration and dissolution characteristics of 23 brands of phenylbutazone tablets were determined. Five (21.7%) of the 23 brands failed to comply with the minimum requirements of the compendia or the regulations appended to the Food and Drugs Act. The in vitro characteristics of four brands were substantially different from those that disintegrated and released the drug satisfactorily. The in vivo characteristics of three of the four brands were compared with those observed for a pharmaceutically acceptable product. The latter product released the drug to the blood quickly, but the former products released the drug only after the tablets had been in the body for six to eight hours and, in the case of one product, released quantities much below those that would be acceptable to the physician. These results show that different products containing the same drug are not necessarily equivalent. This is contrary to the generic equivalency hypothesis which assumes that all products comply with specifications and, therefore, must be clinically effective.


Experience with the use of frozen blood. The long-term preservation of blood by conventional methods, i.e. beyond five to six weeks, has not progressed significantly since World War I. In the past 10 years, freezing techniques have opened new avenues in this field; it is now possible to store blood for periods of five years or more. Several techniques have been developed, either using liquid nitrogen and the rapid-freezing principle or using "cryophylactic agents" such as glycerol, where the rate of freezing is unimportant and the blood is kept at -85 degrees C. The latter methods require washing of the blood before transfusion to remove the intracellular glycerol and thus avoid post-transfusion osmotic hemolysis. At the National Defence Medical Centre in Ottawa, the Huggins' technique of freeze-preservation of blood has been adopted. This novel method of deglycerolization is based on the "reversible agglomeration" of erythrocytes in electrolyte-free sugar solutions. The in vitro and in vivo studies have yielded satisfactory results, and certain applications of the method are discussed.


Studies on infectious mononucleosis: a progress report. The authors recently reported the occurrence of an unstable cytopathic effect and a "first passage" interference phenomenon in tissue culture as well as the detection of antigens by immunofluorescence following inoculation of material from patients with infectious mononucleosis.These tissue cultures have since been discovered to be contaminated by a bacterial L-form. The part played by the contaminant in the results obtained has been determined: it can explain only one of the patterns shown by immunofluorescence.The same labile interference phenomenon has been observed by two independent investigators.


Histological effect of certain pickles on the human gastric mucosa. A preliminary report. The histological effects of several types of pickles and control substances were assessed by repeated suction (per os) biopsies of the gastric antrum in three healthy men. The ingestion of 30 ounces of fukujinzuke (assorted vegetables pickled in soy sauce) or of vinegared gherkins over a three-day period caused marked changes in the surface epithelium and gastric pits in all three subjects. The abnormalities consisted of loss of cellular mucus, nuclear enlargement, prominent nuclear chromatin and an increased number of mitotic figures. All control biopsies were normal, as were biopsies after the ingestion of 30 ounces of raw carrots or cucumbers over a three-day period. This study shows that eating a sufficient quantity of certain types of pickles causes marked changes in the human stomach. Peroral suction biopsy of the gastric antrum appears to be a practical method for testing the effect of various foods on the human gastric mucosa.


Telangiectases simulating hereditary hemorrhagic telangiectasia in scleroderma. Report of two cases.


Veratrum alkaloids in the therapy of myasthenia gravis.


Post-gastrectomy problems in patients with personality defects: the "albatross" syndrome. Of a series of 130 patients undergoing operation for peptic ulcer disease at the Vancouver General Hospital, seven patients with personality defects had a disastrous outcome after operation.THE MAIN FEATURES OF THIS POSTGASTRECTOMY SYNDROME WERE REMARKABLY SIMILAR: persistent abdominal pain without demonstrable cause, intermittent and inexplicable nausea and vomiting, continued analgesic drug dependence and marked nutritional deficiencies. The high incidence was surprising and was not confined to any particular socioeconomic group. Such patients fall into three groups: those with true ulcer disease, those with salicylate addiction, and those without positive signs of ulcer but with chronic complaints. A history of a personality defect should warn the surgeon, and operation should be performed only for the complications of true ulcer disease. Though operation may cure the ulcer, the patient is worse off because the resulting physiologic derangements cannot be accepted or handled by him. These patients continue to haunt the surgeon, and the syndrome has been named the "albatross" syndrome.


Bacterial endocarditis occurring after open-heart surgery. A review was made of 520 patients who survived cardiopulmonary bypass for repair of congenital or acquired heart disease between 1956 and 1965. The incidence of early and late bacterial endocarditis was 2.7%, a figure which was higher than the reported incidence in the pre-bypass era but comparable to the experience reported by others. When those patients who had ball-valve prostheses inserted were considered separately, endocarditis was found to have occurred in 3.9%. The most common infecting organism was Staphylococcus albus (nine of 14 cases). Twelve of the 14 patients died, most often from complications of the infection, such as disruption of patches and prosthetic valves. The infections were difficult to control and in three patients recurred from one to three times. There was no apparent source of infection. Six patients developed infections six to 45 months after operation; the remaining eight had proved endocarditis within two months of operation. With one possible exception, treatment with antibiotics appeared to be ineffective in eradicating the infection unless foreign material was removed from the heart.


The restless leg syndrome.

The restless leg syndrome. The author reviews and provides examples of the restless leg syndrome (Ekbom's syndrome), emphasizing the frequency of the disorder and its distressing symptoms. The syndrome is characterized by a creeping, crawling sensation in the lower legs, usually at night. It is accompanied by an irresistible urge to move the legs, and this movement eventually relieves the symptoms. It is found in 5% of the general population, with a higher incidence in pregnant women and people with anemia, but no vascular, neurological or other abnormalities are found on examination. Patients are treated empirically with vasodilators or intravenous iron. The etiology is unknown.


17-18 trisomy in a Japanese infant.

17-18 trisomy in a Japanese infant.


Idiopathic hemochromatosis i Etiology and pathogenesis.


The social basis of cigarette smoking.

The social basis of cigarette smoking.


Hypogammaglobulinemia, thymoma and ulcerative colitis.


Impairment of carbohydrate metabolism of the squirrel monkey.


Studies on Culex pipiens molestus in Israel. 2. Skin response in man to extracts from the mosquito.


Neurophysiology of extraocular muscles.

Neurophysiology of extraocular muscles.


Pharmacological studies of extraocular muscles.


Antagonistic action of cholesterol on mycobacillin.


The incidence of hypertension long after poliomyelitis.


On the diagnostic criteria of active rheumatoid arthritis.


The complement fixation antibody test in the diagnosis of chronic pulmonary histoplasmosis and blastomycosis.


Methodological problems in behavioral research on disease.


Multiple sclerosis in New Orleans, Louisiana, and Winnipeg, Manitoba, Canada: follow-up of a previous survey in New Orleans, and comparison between the patient populations in the two communities.


Endemic goiter in Greece: salivary iodide clearance in goitrous and nongoitrous persons.


Changes in plasma thyroxine concentration and metabolism, catecholamine excretion and basal oxygen consumption in man during acute exposure to high altitude.


Reciprocal variations in urinary cortisol and aldosterone in response to the sodium-depleting influence of hydrochlorothiazide and ethacrynic acid in humans.


Serum thyrotrophin in myxedema and in asymptomatic atrophic thyroiditis.


Simultaneous metabolism of 3H-corticosterone 21-sulfate and corticosterone-14C in man.


Implantation of the sella turcica with 90-yttrium in the treatment of Cushing's syndrome of pituitary origin.


Taste thresholds in hyper- and hypothyroidism.


A quantitative study of the effects of progesterone and related steroids on the uterus:plasma concentration ratio for radioactive iodide in the rat.


Ovulation in immature rats treated with ovine follicle-stimulating hormone: facilitation by progesterone and inhibition by continuous light.


Influence of pituitary homografts on the weight of seminal vesicles in castrated mice.


Isomerization of radioactive aldosterone at C-17: enzymic purification of the 17-alpha- and beta-isomers.


Failure of the pineal gland to prevent gonadotrophin-induced ovarian stimulation in blinded hamsters.


United States, Beryllium Case Registry (1952-1966). Review of its methods and utility.


Eye-survey study of nuclear-reactor workers.


Cohort study of workers exposed to betanaphthylamine and benzidine.


Fifty years' experience with executive health examinations.


Asthma and occupational stress.

Asthma and occupational stress.


Specific antidote for pesticide poisoning.


Application of pneumatic techniques to surface tension determinations. The surfactometer.


Natural toxoplasma infection sought in insectivorus animals collected at Abu-rawash, Giza, U.A.R.


Studies on intradermal test in Bilharziasis in U.A.R.


Evaluation of the intracutaneous test in the diagnosis of Bancroftian filariasis in Egypt.


Chemotherapy of schistosomiasis with oral dehydroemetine.


The 1965 cholera outbreak in Afghanistan.


Future of automation in pathology.

Future of automation in pathology.


The early stage of amelogenesis as observed in molar teeth of young rats.


Fine structure of interphase liver cell nuclei in acute ethionine intoxication.


Pulmonary alveolar lesions in vagotomized rats.


Lupus nephritis with organized deposits in the kidneys.


Haemoglobin J Baltimore interacting with beta-thalassaemia in an Australian family.


Ultrastructural evidence for an abnormality in proteinpolysaccharide metabolism in lathyritic cartilage.