Toxicity of Panamanian poison frogs (Dendrobates): some biological and chemical aspects. A small Neotropical frog, Dendrobates pumilio, undergoes interpopulational variation in color, degree of toxicity, size, and habits. Differences in body coloration encompass the visible spectrum from red to blue, as well as achromatic black and white. There are wide variations in the degree of toxicity, but these variations are not correlated with supposed warning colors. Extracts of skin yield two toxic compounds characterized as steroidal alkaloids with molecular formulae C(19)H(33)NO(2) and C(l9)H(33)NO(3). The rapid rate of divergent evolution among populations of this frog may result from isolation and chance restriction of original heterozygosity, with subsequent selection acting on different and greatly limited mixtures of alleles.


Synaptic vesicles of inhibitory and excitatory TERMINALS IN THE CEREBELLUM. Populations of synaptic vesicles within cerebellar terminals considered excitatory or inhibitory on the basis of physiological evidence differ with respect to size and shape. Size rather than shape appears to be the main morphological difference between these populations. Elongation of vesicles is depenident on fixation with aldehyde fixatives, and both size and elongation change with age mainly during maturation.


Continuous gas chromatography.

Continuous gas chromatography. Continuous gas chromatography has been achieved with a radialflow chromatographic channel free of packing and formed between two closely spaced (50 to 75 microns) disc surfaces (optically flat and solvent-coated) rotating at one-half or one revolution per second. This technique provides high capacity and immediate response (in a fraction of a second). Mixtures of hydrocarbon gases have been separated at flow rates of 6 to 30 cubic centimeters per minute with 100 to 150 cubic centimeters per minute of nitrogen carrier gas in a chromatographic channel only 39 millimeters long.


Tetrodotoxin derivatives: chemical structure and blockage of nerve membrane conductance. The nerve-impuilse-blocking actions of derivatives of tetrodotoxin have been tested on lobster and squid axons. The block produced by deoxytetrodotoxin was similar to that produced by tetrodotoxin and was probably caused by tetrodotoxin contamination. Tetrodaminotoxin and anhydrotetrodotoxin also produced a similar block but at such high concentrations that tetrodotoxin contamination cannot be ruled out. The hydroxyl group of C(4) and the hemilactal oxygen links play an important role for the nerve-blocking action.


Lactic dehydrogenase and metabolism of human leukocytes in vitro. During transformation and division of lymphocytes in culture, the lactic dehydrogenase isozymes migrate increasingly toward the cathode. With extension of the time in culture, the mitotic index declines, and the isozyme pattern reverts to dominance of those bands that move toward the anode, despite the cellular tendency to anaerobic metabolism. These findings suggest that synthesis of the more slowly migrating lactic dehydrogenase isozymes in this system is related to mitotic activity, and not to the aerobic or anaerobic conditions of cell culture.


Protein metabolism in the developing brain: influence of birth and gestational age. Incorporation of carbon-14-labeled phenylalanine into brain protein of newborn pigs falls sharply within 24 hours after birth. This decrease is related to the time of birth rather than the gestational age of the piglets, although the latter is also associated with a gradual decrease in brain protein synthesis.


Cell-bound immunity to autologous and syngeneic mouse tumors induced by methylcholanthrene and plastic discs. A colony-inhibition assay, was lused to demonstrate specific immunity in vitro against syngeneic mouse sarcomas induced by mlethlylcholanthrene or implanted Dictabelt plastic discs. An immunity to methylcholanthrene-induced tumors could also be demonstrated with lymphocytes derived from the autologous primary tumor-bearing host 3 to 8 days after removal of the primary tumor.


Visual and auditory information processing in children and adults. Children of three ages were compared with adults in a recognition experiment requiring continuous processing of information. The growth in precision for visually presented words is steeper than for auditorially presented words, largely because the former are harder for the first graders and, to a lesser extent, for the third graders. In adults, visual processing of information is at least as good as auditory. The use of receiver operating characteristic curves in describing the data permit greater precision in estimating the capacity of the individual subjects and are particularly useful since the errors of failure to recognize were different from ordinary errors of false recognition, and they occurred in large numbers.


Discrimination learning and inhibition.

Discrimination learning and inhibition.


Methods for facilitation and inhibition of motor activity.


The traditional method of treatment of the cerebral palsied child.


Traditional exercise regimens for the hemiplegic patient.


Demonstration of the traditional approach in the treatment of a patient with parkinsonism.


Demonstration of traditional therapeutic exercise techniques in the treatment of arthritis.


Exploratory and analytical survey of therapeutic exercise. Discussion on terminology.


Exploratory and analytical survey of therapeutic exercise. Discussion on common denominators.


Exploratory and analytical survey of therapeutic exercise. Discussion on the prescriptive relationship.


Research in physical therapy.

Research in physical therapy.


Exploratory and analytical survey of therapeutic exercise. Tenth question and discussion period.


Exploratory and analytical survey of therapeutic exercise. Eleventh question and discussion period.


Exploratory and analytical survey of therapeutic exercise. Fourth question and discussion period.


Disorders of motion.

Disorders of motion.


Normal human excretory functions.

Normal human excretory functions.


Pregnancy and labor from the vantage point of the physical therapist.


Neuromotor pathologies of speech.

Neuromotor pathologies of speech.


Considerations for curriculum development--1976.


Teaching of therapeutic exercise. Summary of group work and pertinent papers.


Analysis of traditional regimens of therapeutic exercise.


The Bobath concept in treatment of neurological disorders; a neuro-developmental treatment.


Neuromuscular reflex therapy as an approach to patient care.


Principles and techniques of the Brunnstrom approach to the treatment of hemiplegia.


Proprioceptive neuromuscular facilitation.


An interpretation of the approach of Rood to the treatment of neuromuscular dysfunction.


Exploratory and analytical survey of therapeutic exercise. Seventh question and discussion period.


Exploratory and analytical survey of therapeutic exercise. Eighth question and discussion period.


Exploratory and analytical survey of therapeutic exercise. Ninth question and discussion period.


Ureteral substitution with ileum.

Ureteral substitution with ileum.


Intravenous ethyl alcohol in small artery surgery.


A simple biopsy knife.

A simple biopsy knife.


Duplications of the rectum.

Duplications of the rectum.


Fifty per cent gastrectomy or pyloroplasty, with vagotomy, for duodenal ulcer. I. Effect upon Hollander test results.


Submental incision for resection of cancer of the floor of the mouth.


Trichobezoar as a cause of obstruction of the colon.


Rhabdomyosarcoma of the spermatic cord. A review and case presentation.


Metastatic disease of the lung.

Metastatic disease of the lung.


Comparison between sham feeding meat and teasing with meat on canine gastric motility.


Treatment of septic shock from colon perforation.


Causal and action models in social psychiatry.


The isoenzymes of lactic dehydrogenase. II. Pulmonary embolism, liver disease, the postoperative state, and other medical conditions.


Technics for chronic drainage of bladder.


Intrauterine transfusion.

Intrauterine transfusion.


Tremulous iris.

Tremulous iris.


Identification by hair.

Identification by hair.


Efficacy and applicability of mass B. C.G. vaccination in tuberculosis control.


Physical and mental disabilities of 1,190 ordinary motorists.


Diurnal variations of platelet stickiness compared with effects produced by adrenaline.


Buccal oxytocin after amniotomy for induction of labour.


Initial cardiac tamponade in acute leukaemia.


Malabsorption.

Malabsorption.


Selection of patients for haemodialysis. Surgeon's point of view.


Selection of patients for haemodialysis. Doctor's duty to his patient.


Aspects of postgraduate medicine. 8. Postgraduate medical centers--Stoke Mandeville and Birmingham.


Hazards of peritoneal dialysis.

Hazards of peritoneal dialysis.


Silicosis and alveolar proteinosis.

Silicosis and alveolar proteinosis.


Toxic effects of aerosol moth spray.

Toxic effects of aerosol moth spray.


Trigeminal neuralgia: complications of its surgical treatment.


Renal failure and low-molecular-weight dextran.


Burkitt's tumour in the West Nile District Uganda, 1961-5.


Acute gastric ulceration associated with drug therapy.


Editorial: Canadian testing services for licensing of professional graduate nurses.


Wadhams' outpost nursing station.

Wadhams' outpost nursing station.


Medical intensive care.

Medical intensive care.


Poison control as a nursing function.

Poison control as a nursing function.


Drug protection for Canadians.

Drug protection for Canadians.


The child care worker in psychiatry.

The child care worker in psychiatry.


A tropical disease--in Quebec.

A tropical disease--in Quebec.


Prospects from the treatment of thyroid carcinoma with radioiodine.


Acute mitral incompetence.

Acute mitral incompetence.


The significance of anaemia in radiotherapy.


Bone metastases, osteoporosis and radiation necrosis in breast cancer.


An intraosseous ependymal cyst.

An intraosseous ependymal cyst.


True aneurysm of the middle meningeal artery, cranial Paget's disease and hypertension: a triad.


The radiological demonstration of osseous metastases. Experimental observations.


Bilateral rete carotidis in man.

Bilateral rete carotidis in man.


Chronic non-specific spinal epidural granuloma.


Irradiation of the masopharynx in children. A survey of patients 5-20 years after treatment for lymphoid hyperplasia.


Carcinoma of the breast: a review of clinical and laboratory examinations relating to treatment policy.


Radioactive phosphorus as an aid to the diagnosis of pigmented skin lesions.


Angiographically demonstrated abnormal vascular pattern in a pituitary adenoma.


The effects of intra-arterial injections of radiographic contrast media on the mesenteric circulation in rats.


Pulmonary infarction simulating bronchial carcinoma.


Limitations of lateral pelvimetry.

Limitations of lateral pelvimetry.


Studies in stress glycosuria. II. Glycosuria and blood sugar elevation in alloxanized subdiabetic white rats subjected to electric shock stress.


Effect of DL-p-fluorophenylalanine on Paramecium aurelia during the cell generation cycle.


Studies on the mechanism of serotypic transformation in Paramecium aurelia. II. The effects of actinomycin D, purimycin, and chloramphenicol on transformations induced by patulin, acetamide, and antiserum.


Guidelines for centralized purchasing.

Guidelines for centralized purchasing.


DNA synthesis in 5-bromouracil tolerant HeLa cells. An autoradiographic study.


Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture.


The application of verbal behavior analysis to the study of psychological defense mechanisms. IV. Speech pattern associated with depressive behavior.


Dream interruption insomnia.

Dream interruption insomnia.


Sibling order, premorbid adjustment and remission in schizophrenia.


Alpha chloralose-activated electroencephalograms in psychiatric patients.


Familial myotubular myopathy: a clinical, pathological, histochemical, and ultrastructural study.


Familial hypokalemic periodic paralysis with permanent myopathy. A clinical and ultrastructural study.


Implantation of the rat embryo: further histochemical observations on carbohydrate, RNA, and lipid metabolic pathways.


The recognition and isolation from urine and serum of a peptide inhibitor to calcification.


Relative roles of patassium and chloride in correction of hypokalemic hypochloremic alkalosis.


The spatial distribution of parenchymal cell proliferation during regeneration of the liver.


Acute metabolic acidosis following exercise in normal human subjects.


Clinicopathologic conference. Case presentation (BCH 469861).


Complex congenital cardiac malformation: corrected transposition, origin of both great vessels from the anatomic right ventricle, common ventricle, and dextroversion.


Congenital cerebrospinal fluid otorrhea via a defect in the stapes footplate.


The role of the orthopedic surgeon in the management of the child with muscle weakness.


Autoresorption of nonautogenous transplants: contribution to the problem of the possibility of graft adaptation.


The role of the orthopedic surgeon in cerebral palsy.


Cytotoxicity of dichlorodiphenylacetic acid (DDA) upon cultured KB and HeLa cells, and its reversal by mevalonic acid.


Action of progesterone ans synthetic progestogens on estrogen-induced ovarian growth.


Capacitation of rabbit spermatozoa: species specificity and organ specificity.


A leukemogenic filtrable agent from chemically-induced lymphoid leukemia in C57BL mice.


Influence of a fat-enriched meal on human serum (L-phenylalanine-sensitive) "intestinal" alkaline phosphatase.


Effect of anthocyanin pigments on certain enzymes.


Effect of advancing age on thyrotropin content of the pituitary and blood of the rat.


Effects of metaraminol perfusion of kidney, liver, or brain on renal response to saline infusion in the dog.


Effect of splenectomy on renal arteriovenous reduction in hemoglobin concentration in the anesthetized dog.


Effect of increased urine excretion on renal arteriovenous reduction in hemoglobin concentration in the anesthetized dog.


Mediation of aldosterone induced anti-natriuresis via RNA-synthesis de novo.


Urea excretion in the potassium-deficient rat.


Hematopoietic changes in mice following Bordetella pertussis vaccine.


Epiphyseal growth zones in acute lathyrism. Uptake and distribution of 35SO4 in cartilage and bone.


Labeling of serum, liver, and testicular lipids following the injection of arachidonic-1-C14 acid.


Failure to provoke the local Shwartzman reaction with thrombin.


Neonatal cortisol administration and immunological impairment in the adult rat.


Location of the estrogen effect on uterine glucose metabolism.


Effect of guar gum and pectin N. F. on serum and liver lipids of cholesterol fed rats.


Potentiation of hemolytic plaque formation by incubation of immunized spleen cells in phenothiazine derivatives.


Effect of advancing age on thyroid hormone secretion rate of male and female rats.


Electrolyte-fluid exchanges and renal tissue composition in vasopressin treated polyuric-polydipsic rabbits.


Studies with clearing factor IV. Fatty acid exchange reaction catalyzed by clearing factor.


Dependency of filtration and P-aminohippurate (PAH) secretion on Na reabsorption in the obstructed dog kidney.


Molluscan schistosomiasis mansoni: effect of 2 analogues of chloramphenicol on both parasite and host.


Effect of corticosteroids on amino acid incorporation into protein by rat liver ribonucleoprotein particles.


Distribution of calcium and strontium in the blood of the laying hen.


Influence of hydrazine on the distributions of free amino acids in mouse liver.


A vascular permeability defect in experimental cholera.


Lifetime activity studies in mice from ten to thirty generations of x-irradiated progenitors.


Capillaries in heart and skeletal muscle of dog and rabbit.


Circadian rhythm in duration of salicylate excretion referred to phase of excretory rhythms and routine.


Effect of hemorrhage on hepatic potassium movements.


Comparison of bouyant density of two mutants of ECHO 6 by density gradient ultracentrifugation.


Influence of cholesterol on estrogen induced aortic ruptures in turkeys.


Response of the isolated dogfish gastric mucosa to histamine.


Diuretic action of glycerol in dogs.

Diuretic action of glycerol in dogs.


Renal acid deoxyribonuclease: observations on distribution and cell relationship.


Nutritional requirements for reproduction of a temperature sensitive nematode, reared in axenic culture.


Cyclophosphamide inhibition of experimental allergic encephalomyelitis in Wistar rats.


Influence of intestinal content on radiation lesions of the small intestine.


Low carcinogenicity of the K-region epoxides of 7-methylbenz(a)-anthracene and benz(a)anthracene in the mouse and rat.


Antitumor effects of kethoxal-bis(thiosemicarbazone) and 6-mercaptopurine in neonatally thymectomized mice.


Effect of radiation plus endotoxin on the Walker 256 rat carcinosarcoma.


Influence of Na+ on synthesis of a substrate entry mechanism in a marine bacterium.


Effect of hyperglycemia on fructose biosynthesis in mouse seminal vesicles.


Lung lipase levels in normal rats and rats with experimentally produced fat embolism.


Glutamate-induced hyperglycemia.

Glutamate-induced hyperglycemia.


Suppression of experimental atherosclerosis in dogs by dietary linoleic acid.


Comparison of ratio and covariance analysis of TSH assays.


Congenital defects.

Congenital defects.


Genetics and congenital defects.

Genetics and congenital defects.


Congenital malformations from the obstetrician's point of view.


The SURGICAL APPROACH TO SOME CONGENITAL ANOMALIES.


Cardiac arrest. Resuscitation results.

Cardiac arrest. Resuscitation results.


Serum lipids, nutrition and atherosclerotic complications in man.


Uptake of oxygen and substrates in human skeletal muscle. Studies on muscle and subcutaneous fat tissue in one healthy and one diabetic subject before and after insulin.


The effect of coffee on the function of the sympatho-adrenomedullary system in man.


A case of multiple arterial thromboses after oral contraceptives and ergotamine. A 35-year-old previously healthy woman started using oral contraceptives in May 1965.  In June ergotamine was prescribed for right temporal headaches.  On November 4 she took 5 ergotamine tablets between 4-7 AM.  By 9 AM she was confused and did not answer when spoken to.  She was admitted to the hospital at 11 AM with an apoplexy picture.  On November 6 carotid angiography on the right side showed a total occulsion of the internal carotid artery.  An attempt at thrombectomy proved fruitless.  In spite of intensive therapy, the patient died in cardiac arrest on the 3rd post operative day.  Autopsy showed thrombotic masses in the right carotid artery and left ventricle.  A contributory cause may have been the use of oral contraceptives in conjuction with ergotamine medication.


Trace elements in drinking water and death rate in cardiovascular disease.


Studies in sarcoidosis. IV. Serum immunoglobulin levels.


Excretion of trace elements in two penicillamine-treated cases of cystinuria.


Bone marrow in acute renal failure.

Bone marrow in acute renal failure.


Pharmacodynamic studies in aortic regurgitation.


Complete transposition of the great vessels with anatomic obstruction of the outflow tract of the left ventricle. Surgical implications of anatomic findings.


Right ventricular volumes in pulmonic valve disease.


Measurement of the shortening of cardiac fibers in man.


Studies on ectopic atrial rhythms in dogs.


Aortico-left ventricular tunnel. A new concept.


Postoperative use of the hydrogen-sensitive, platinum-tipped electrode. Detection of residual left to right shunts.


Left ventricular-right atrial communication.


Ebstein's malformation of the tricuspid valve in the neonate. Functional and anatomic pulmonary outflow tract obstruction.


Congenital absence of the pulmonic valve. Report of a case in a seventy-three-year-old man.


Severe myocardial damage and heart failure in scorpion sting. Report of five cases.


Idiopathic hypertrophic cardiomyopathy involving the right ventricle.


Cor triatriatum in the adult. Complicated by mitral insufficiency and aortic dissection.


Origin of the right pulmonary artery from the aorta. A clinical-pathologic study of two types based on caliber of the pulmonary artery.


The composition of rectal mucus in cystic fibrosis.


Salivary studies in cystic fibrosis.

Salivary studies in cystic fibrosis.


Individual differences in attention. The relation between infants' condition at birth and attention distribution within the first year.


Infant orientation to hearing aids: a new approach.


Social patterns and diabetic glucosuria. A study of group behavior and diabetic management in summer camp.


Primary familial erythrocytosis.

Primary familial erythrocytosis.


Familial and congenital simple anhidrosis.


The intrathoracic kidney. Report of a case.


Double aneuploidy: trisomy-18 and Klinefelter's syndrome.


Percutaneous absorption of hydrocortisone in children.


Transverse myelitis from injection of penicillin.


High-solute formulas.

High-solute formulas.


Procainamide HCl-induced lupus syndrome in a child with myotonia congenita.


Use of brain scans.

Use of brain scans.


The role of the "indifferent" cell of the tubal epithelium.


Current trends in therapeutic termination of pregnancy. A review of therapeutic abortion performed at Mt. Sinai Hospital, New York, during the years 1953-1964 is presented.  During this period the total incidence of therapeutic abortions increased from 61 to 99 per 10,000 deliveries.  Abortions for psychiatric reasons rose from 24 to 56 per 10,000 deleveries, whereas abortions for medical and genetic reasons remained stable (12 and 18 per 10,000 deleveries, respectively).  The incidence of abortions for clearly defined medical and psychiatric reasons was similar for private and ward patients.  The incidence of abortions for genetic conditions or malignancies with psychoemotional or social aspects was markedly and consistently higher for private patients.


Absorption of estrogen and progesterone by intrauterine devices.


Cancer of the breast in pregnancy and during lactation.


An evaluation of the vacuum extractor in series of 201 cases.


Comparison of the estimated and actual maturation index.


Comparative study of delivery by vacuum extractor and forceps.


Quantitative studies in fetal electrocardiography. I. Prenatal prediction of the condition of the infant at birth (Apgar rating).


Individual differences in heart rate variability in the human fetus.


Urinary gonadotropin-inhibiting substance in Stein-Leventhal syndrome and other anovulatory states.


Human menopausal gonadotropins for anovulation and sterility. Results of 7 years of treatment.


Fetal heart rate and acid-base status in the assessment of fetal hypoxia.


Histochemical study of the interstitial gland tissue in the ovaries of nonpregnant women.


Neoplastic sequelae of allogenic disease. II. Electron-microscopic study of a neoplasm (reticuloendotheliosis) in survivors of the graft-vs.-host reaction.


The role of capillaries in the pathogenesis of delayed radionecrosis of brain.


The histogenesis of the branchial cyst. II. A study of the lining epithelium.


Inhibition of intercellular matrix synthesis during ingestion of inorganic lead.


Cardiovascular studies on copper-deficient swine. IX. Repair of vascular defects in deficient swine treated with copper.


The lipid content of amyloid fibrils purified by a variety of methods.


Neurohormonal factors influencing "spontaneous" arteriosclerosis in rabbits.


Selective, acute destruction of granule-cell precursors in the dentate gyrus by proton irradiation.


Eosinophilic pleural effusion. A condition with multiple causes.


The internal surface area of nonemphysematous lungs.


Smoking, pulmonary function, and respiratory symptoms in a college-age group.


Smoking and morbidity in a college-age group.


Physiologic changes in the lungs of rabbits continuously exposed to nitrogen dioxide.


The preparation and mouse evaluation of nonviable, solvent-extracted antituberculous vaccines: (a) main assay findings; (b) stability of nonviable vaccines; (c) a major disadvantage of intravenous challenge.


A polypeptide skin-test antigen from Nocardia asteroides. I. Production, chemical, and biologic characterization.


Blastomycosis of the central nervous system. II. A report of nine cases from the Veterans Administration Cooperative Study.


Uric acid oxidation by mycobacteria.

Uric acid oxidation by mycobacteria.


Primary pulmonary sporotrichosis.

Primary pulmonary sporotrichosis.


Micobacterium intracellulare.

Micobacterium intracellulare.


Education of patients by tuberculosis hospitals.


Spontaneous pneumothorax in small community hospitals.


The role of long-term continuous oxygen administration in patients with chronic airway obstruction with hypoxemia.


Asphyxial death: the roles of acute anoxia, hypercarbia and acidosis.


Bronchopulmonary lavage in normal subjects and patients with obstructive lung disease.


Iron treatment in sideropenic intravascular hemolysis due to insufficiency of Starr-Edwards valve prostheses.


Propranolol in the treatment and prevention of cardiac arrhythmias.


Unusual synovial fluid findings in Reiter's syndrome.


Anesthetic management of pheochromocytoma employing halothane and beta adrenergic blockade. A report of fourteen cases.


Chronic pyelonephritis at autopsy.

Chronic pyelonephritis at autopsy.


Cyclopropane effects on renal function in normal man.


Hemodynamic effects of experimental hypercitremia.


The output of protein after pancreozymin. A test of pancreatic function.


The prognostic significance of proteinuria in young college students.


Components of the alveolar-arterial oxygen tension difference in anesthetized man.


Use of medium chain triglycerides in malabsorption.


Pyridostigmin (mestinon) as an antagonist of d-tubocurarine.


Characteristics of the neuromuscular block with succinylcholine and decamethonium in man.


Recurrent epididymitis in sarcoidosis. Report of a patient treated with corticosteroids.


Compassion, computers, and the regulation of clinical technology.


Calcified megakaryocytes in a case of thrombocytopenia.


Central and peripheral effects of muscarinic cholinergic blocking agents in man.


Complications of falciparum malaria and their treatment.


Who speaks for the patient?

Who speaks for the patient?


A new role for glucagon.

A new role for glucagon.


Nosocomial salmonellosis due to carmine.


The demonstration of dehydrogenases and diaphorases in cells of peripheral blood and bone marrow.


Folate deficiency associated with drug therapy for tuberculosis.


Iron-laden mitochondria in reticulum cells of hypersiderotic human bone marrows.


Studies on the mechanism of in vitro acid hemolysis in paroxysmal nocturnal hemoglobinuria.


Observations on Fe59 labeled bone marrow ferritin.


The application of freeze-cleaving technics to studies on red blood cell fine structure.


The Philadelphia chromosome and galactose-1-phosphate uridyl transferase.


Effect of thyroid hormones on metabolism of D,L-norepinephrine by isolated rat liver.


Parathyroid-induced changes in collagen and calcium metabolism in vivo.


The adrenal cortex and the regulation of water exchange during food deprivation.


Depression of enzyme activity by cortisone: an effect on serine metabolism.


Metabolism of radioactive estrone and estradiol by the golden hamster.


A functional role for 20-alpha-hydroxypregn-4-en-3-one in the rabbit.


Extrathyroidal thyroxine formation in completely thyroidectomized rats.


Maintenance and function of corpora lutea in rabbits depend on estrogen.


Effect of lethal x-irradiation on urinary cortisol and 2-alpha- and 6-beta-hydroxycortisol excretion patterns and production rates in guinea pigs.


Reversal of the inhibition of TSH secretion due to acute stress.


Aldosterone secretion in magnesium-deficient rats.


Comparison of early effects of thyrotropin and long-acting thyroid stimulator on thyroid secretion.


Student attrition at colleges of veterinary medicine.


Ion transport by heart mitochondria. VII. Activation of the energy-linked accumulation of Mg++ by Zn++ and other cations.


Rat liver glutamyl ribonucleic acid synthetase. I. Purification and evidence for separate enzymes for glutamic acid and glutamine.


On the mechanism of activation of L-threonine deaminase from Clostridium tetanomorphum by adenosine diphosphate.


Composition and mass of peptides released during tryptic and chymotryptic hydrolysis of myosin.


Macroion interactions involving components of the cytochrome system. V. Reduction of cytochrome c by synthetic polysaccharides.


Oligonucleoides from yeast tyrosine transfer ribonucleic acid.


Hydroxyurea reversal of inhibition and use as a cell-synchronizing agent.


Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase.


Large oligonucleotides isolated from yeast tyrosine transfer ribonucleic acid after partial digestion with ribonuclease T1.


Rapid activation-inactivation of liver uridine diphosphate glucose-glycogen transferase and phosphorylase by insulin and glucagon in vivo.


Difference in the chemical reactivity of the disulfide bonds of trypsin and chymotrypsin.


Fluorescence depolarization measurements on pyrene butyric-bovine serum albumin conjugates.


Stoichiometric inhibition of various 3-beta-hydroxysteroid dehydrogenases by a substrate analogue.


Immunologic studies with urinary follicle stimulating hormone.


Inhibition of 3-beta-hydroxysteroid dehydrogenase from Pseudomonas testosteroni by various estrogenic and progestinic steroids.


Life span of parents of diabetic subjects.


Gluconate carrier in 47Ca kinetic studies.


Urinary amino acids in pregnancy, following progesterone, and estrogen-progesterone.


Maternal urinary estrogen excretion: effect of adrenal suppression.


Biphasic nature of blood glucose and free fatty acid changes following intravenous nicotinic acid in man.


Radioimmunoassay for human follicle stimulating hormone.


Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex.


Changes in the sensitivity of the sweat glands of the cat after denervation.


Monoamine levels and neuronal degeneration in rat brain following lateral hypothalamic lesions.


A pharmacologic analysis of the significance of the chemical functional groups of oxytocin to its oxytocic activity and on the effect of magnesium on the in vitro and in vivo oxytocic activity of neurohypophysial hormones.


The relation between norepinephrine content and response to sympathetic nerve stimulation of various organs of cats pretreated with reserpine.


The capacity of different digitalis materials to induce ventricular rhythm disturbances in the reserpine-pretreated cat.


A mathematical analysis of the interval-strength relationship in the rat ventricle strip and its modification by fluoroacetate.


The in vivo effects of beta adrenergic stimulation and blockade on the human uterus at term.


A biochemical basis for the renal activity of N-7-acetylchlorothiazide.


Effects of dopamine on renal function and hemodynamics in the dog.


Cholinergic properties of the relay junctions of the primary afferent pathway.


Localization of tritiated serotonin in rat brain by electron-microscopic autoradiography.


The effect of drugs on the release of norepinephrine-H from central nervous system tissued by electrical stimulation in vitro.


Interaction between facilitating and depolarizing drugs at the neuromyal junction of the cat.


Modification of the effects of tranquilizers in animals treated with alpha-methyl-l-tryrosine.


Biomedical communication.

Biomedical communication.


Maze learning after the administration of antidepressant drugs.


Antagonism by monoamine oxidase inhibitors of alpha-methyltyrosine-induced catecholamine depletion and behavioral depression.


Immunologic competence of thoracic duct cells. II. Ultrastructure.


Comparative pathology.

Comparative pathology.


The prevention of fatty liver by administration of adenosine triphosphate.


Effect of in vivo and in vitro ethanol administration on liver lipid peroxidation.


Study on hump removal in rhinoplasty.

Study on hump removal in rhinoplasty.


Cochlear otosclerosis. Report of a case, with postmortem histologic findings.


Gliomas involving the temporal bone clinical and pathological aspects.


The transmeatal approach to middle ear and mastoid surgery in cholesteatoma.


Osteomyelitis of the maxilla due to an anaerobic organism. Case report and management.


Myringostomy by use of a fixed prosthesis.


Conservative surgery for chronic maxillary sinusitis.


Inverting papillomata of the nose and sinuses.


Congenital cyst of the larynx in infants.


Secretory otitis media in children: a study of 540 children.


Rare tumors of the ear, nose, and throat.


Prophylactic antibiotics in human stapedectomy.


"Asymptomatic" protruded lumbar disk as a cause of urinary retention: preliminary report.


Squamous-cell carcinoma of the anal canal and anus: current status of therapy.


Modification of the assay of urinary follicle-stimulating hormone for routine diagnostic use.


External biphase pin method for fixation of mandible.


Attempted suicide.

Attempted suicide.


Medicine in South Vietnam today. 7. Binh Dinh Province--rain, red mud and more fighting.


Delayed recognition of postoperative hypoparathyroidism.


The indications for meniscectomy.

The indications for meniscectomy.


Actions of a diuretic (cyclothiazide) effective on administration by mouth on normal man.


Recurrent hematuria and focal nephritis.


Folic acid deficiency in pregnancy.

Folic acid deficiency in pregnancy.


Independence of blood pressure and aldosterone secretion.


Paralytic poliomyelitis in a contact of a vaccinated child.


High myocardial threshold to an artificial pacemaker--report of a fatal case.


Death in the automobile.

Death in the automobile.


World population projection with special reference to Southern Africa.


An evaluation of gastric acid secretion in kwashiorkor by means of the augmented histamine test.


Iron absorption and liver iron deposition in the rat.


A comparison of two antibiotic regimens in the treatment of gastroenteritis in malnourished children with a one-year follow-up of their subsequent progress.


Sex, age and race variations in the body measurements of white, Bantu, Coloured and Indian children aged 7-15 years.


Takayasu's arteritis--case report of an African female.


Management of Colles' fracture.

Management of Colles' fracture.


Hexokinase isoenzymes in human erythrocytes: association of type II with fetal hemoglobin. Hexokinase activity in human erythrocytes is associated with three electrophoretically distinct bands. Normal adult erythrocytes contain hexokinases Types I and III. Type II hexokinase is present in the erythrocytes of newborn infants and absent from those of normal adults; it is, however, present in erythrocytes of adults with hereditary persistence of fetal hemoglobin. Type II hexokinase and fetal hemtoglobin appear to be associated.


Magnetic fields around the torso: production by electrical activity of the human heart. A search was made outside the torso for fluctuating magnetic fields produced by the heart. Detector and subject were housed in a highly shielded enclosure. Magnetic signals with amplitudes of 10(-8) to 10(-7) gauss were detected synchronously with the electrocardiogram, confirming previous reports. A magnetocardiographic chest map, consisting of the magnetic field plotted against time at various spatial positions, shows genteral QRS and T-wave structure, as in the electrocardiogram; this structure varies with spatial position.


Amino acids and the spikes from the retinal ganglion cells. The effects of amino acids or mixtures of amino acids on the spike discharges from the optic ganglion cells were studied. Mixtures of amino acids have different effects than single amino acids. Proper composition of excitatory and inhibitory amino acids can enhance only the light-induced spikes without giving rise to any spontaneous discharges. It is implied that amino acids may play an important role in the regulation of the general sensitivity of cells in the central nervous system.


Adjuvant activity of erythrocyte isoantigens. Erythrocyte isoantigens determined by the B blood-group locus of chickens enhance the immune response to weak isoantigens. This adjuvant action occurs if the antigens are present on the same erythrocyte, and the recipients are capable of responding immunologically to the B antigens.


Plastic films on plants as antitranspirants. Plastic-film-type antitranspirants are more permeable to water vapor than to carbon dioxide. Photosynthesis in treated plants is reduced to the same or greater extent than transpiration, except under conditions of stress, when photosynthesis in treated plants is greater than in controls. This exception is attributed to reduction of stress, as the selective permeability of the films to gases would tend to produce the reverse effect.


Transverse tubule apertures in mammalian myocardial cells: surface array. The technique of " freezeetching" tissues for electron microscopy has permitted observation of the external apertures of the transverse tubules. The apertures appear on the cell surface in approximately parallel rows, which can be interpreted as corresponding longitudinally to the spaces between the myofibrils and transversely to the Z regions of the myofibrils.


Dechlorination of DDT in frozen blood.

Dechlorination of DDT in frozen blood. Dechilorination of a commercial mixture of o, p'-DDT and p, ppDDT to p, p'-DDD and p, p'-DDE occiurs in avian blood stored at-20 degrees C, indicatinig nonenzymalic degradation. The subsequent disappearance of these two metabolites suggests conversion to other metabolites which cannot be detected by gas chromatography with an electron-captutre detector.


Human fibroblasts infected with rubella virus produce a growth inhibitor. A protein that inhibited mitosis of normal human diploid cells was demonstrated in extracts of WI-38 cells that were infected with rubella virus and that had gone into mitotic arrest subsequent to infection. A possible mechanism for the pathogenesis of the rubella syndrome is suggested.


Deuterium and oxygen-18 in natural waters: analyses compared.


Separation of transit of auxin from uptake: average velocity and reversible inhibition by anaerobic conditions. An applied pulse of (14)C-indole-3-acetic acid moved down aerobic corn coleoptiles at about 15 millimeters per hour. When sections with a moving pulse were transferred to nitrogen, the rate fell below 2 millimeters per hour. This inhibition was completely reversible; sections returned to air moved the same amount of auxin as untreated aerobic controls.


Basic science in mission-oriented endeavor. Shannon on pragmatism; Weinberg and Orlans disagree on the role of the university in basic research.


Electron microscopy.

Electron microscopy.


The spectrum of gonadal dysgenesis. A clinical, cytogenetic, and pathologic study.


Role of conization in the treatment of cervical carcinoma in situ.


Cell, tissue, and organ culture.

Cell, tissue, and organ culture.


The nurse-midwife as a mediator of contraception.


Dyskaryosis in cervical cytology and its relationship to trichomoniasis therapy. A double blind study.


Accuracy of a passive hemagglutination inhibition method for the determination of chorionic gonadotropin in the urine.


Urine white-cell excretion and the pyrogen test in pregnancy hypertension.


Placental lactate production in toxemia of pregnancy.


The 2 hour sulfobromophthalein retention test and the transaminase activity during oral contraceptive therapy.


Perivillous fibrin deposition in the human placenta.


Arterial and venous pressures in the human umbilical cord.


Intervillous fibrin deposition--the Rohr, Nitabuch, and Langhans striae. Evolution of the ''additional'' cytotrophoblast in the normal placenta in the second trimester of pregnancy.


Schistosoma mansoni of the ovary.

Schistosoma mansoni of the ovary.


Estimation of fetal weight in utero by simple external palpation.


Tumor metastasis to the eye. 3. The fate of circulating tumor cells to the eye.


The influence of antibody and normal serum factors on the respiration of toxoplasma gondii.


Treatment of urinary bilharziasis in a small focus with sodium antimony dimercaptosuccinate (astiban).


Egg and pigment production in Schistosoma mansoni infections of the white mouse.


The inhibition of granuloma formation around Schistosoma mansoni eggs. I. Immunosuppressive drugs.


Quantitative aspects of Trichinella antigen-antibody reactions with a modified passive cutaneous anaphylactic procedure.


Relation of age, sex, and microfilaria density to treatment of sub-periodic filariasis with diethylcarbamazine.


Hookworm infection and intestinal absorption amongst Africans in Uganda.


Use of adult chickens as arbovirus sentinels. I. Viremia and persistence of antibody in experimentally inoculated adult chickens.


Evaluation of the cephalic phase of gastric secretion: comparison between sham feeding meat and teasing with meat on canine gastric secretion.


Articular and vascular manifestations of polymyalgia rheumatica.


Side-effects of indomethacin.

Side-effects of indomethacin.


Allopurinol in the treatment of uraemic patients with gout.


Phenylbutazone in the treatment of Tietze's syndrome.


Use of the hypospray jet injector for intra-articular injection.


Degenerative joint disease in Praomys (Mastomys) natalensis.


Tryptophan metabolism. A hitherto unreported abnormality occurring in a family.


Lichen sclerosus et atrophicus in children. A report of 24 cases.


Familial erythema of acral regions.

Familial erythema of acral regions.


Hand eczema and atopy in housewives.

Hand eczema and atopy in housewives.


Pemphigus vulgaris involving the cervix uteri.


Iatrogenic miliaria crystallina due to bethanechol.


Metastatic calcinosis cutis with renal hyperparathyroidism.


Generalized granuloma annulare. A report of a case and review of the literature.


Indomethacin in ocular inflammation in rabbits.


Betamethasone 17-valerate. A custom-made topical corticosteroid.


The symptom of vertigo.

The symptom of vertigo.


Vertigo in cerebrovascular disease.

Vertigo in cerebrovascular disease.


Vertigo with diseases of the central nervous system.


The vertigo of endolymphatic hydrops.

The vertigo of endolymphatic hydrops.


Demyelinating diseases as a cause for vertigo.


Paroxysmal postural vertigo and vestibular neuronitis.


Vestibular tests.

Vestibular tests.


Arteriography in the differential diagnosis of vertigo.


Summation of the symposium on the vertiginous patient.


The audiological examination as an aid in diagnosis.


Recurrent meningitis due to congenital petrous fistula. A case report.


Improved wire-crimper for stapes work.

Improved wire-crimper for stapes work.


Purification without loss of viability of neoplastic plasma-cells from the ascites passaged mouse myeloma, X5563.


Left atrial impulse formation in atrial flutter.


Conversion of atrial fibrillation and flutter by propranolol.


Pulmonary artery banding for ventricular septal defect.


Modification of cardiovascular responses by propranolol.


Lung function in patients with left-to-right shunts.


Catheterization of the left atrium by Ross needle and Seldinger wire techniques.


Eight-hour electrocardiogram: technique and clinical application.


Cardiomyopathy and pregnancy.

Cardiomyopathy and pregnancy.


Chronic haemolysis occurring in patients following cardiac surgery.


Geographical aspects of acute myocardial infarction in India with special reference to patterns of diet and eating.


Improved design for a transseptal needle.


Determination of pressure in the pulmonary artery by external graphic recordings.


Peripheral pulmonary artery murmur of atrial septal defect.


Movement of mitral valve cusps in relation to first heart sound and opening snap in patients with mitral stenosis.


Effects of two years' intermittent stay at high altitudes on the pulmonary blood volume in man.


Oxygen extraction rate of the myocardium at rest and on exercise in various conditions.


Right oblique transthoracic electrocardiogram.


Diagnostic auscultatory complex in coarctation of the aorta.


Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.


Phonocardiogram of the ball-and-cage aortic valve prosthesis.


Successful early repair of acquired ventricular septal defect after myocardial infarction.


Fatal fungal infection following open-heart surgery.


Inflammation induced by dimethylsulfoxide (DMSO). 1. Ultrastructural investigation of preinflammatory phase.


Differences in bone formation induced by urinary bladder autografts, homografts and pedicle grafts.


A comparative electron microscopic study of human and rat colonic polyps and carcinomas.


Morphogenesis of human aortic coarctation.


Studies of the pathogenetic role of humoral antibodies reacting with subcellular organ antigens. I. Active immunization of rabbits with rat-organ antigens.


Molecular forms of rabbit antibody synthesized during the primary response to human albumin.


Cardiac murmurs in old age: a clinico-pathological study.


Studies of the pathogenetic role of humoral antibodies reacting with subcellular organ antigens. II. Passive immunization of rats with anti-rat rabbit immune sera.


Response of human blood lymphocytes to tuberculin PPD in tissue culture.


Choreiform movements as side effects of phenothiazine medication in geriatric patients.


Allegedly nonpsychiatric patients in nursing homes.


The fitting of a patellar-tendon-bearing prosthesis 47 years after the original below-knee amputation.


The Rotterdam prosthesis--a simple prosthesis for the aged.


Anemia in the aged.

Anemia in the aged.


An internist's observations on thioridazine in the very elderly.


Water and solute movement in the small intestine of patients with sprue. Water and electrolyte movement in the jejunum of normal subjects and patients with sprue was measured during perfusion with isotonic electrolyte solutions. Normal subjects absorbed water, sodium, and potassium. By contrast, in patients with sprue (seven with adult celiac sprue and one with tropical sprue) who had diarrhea and steatorrhea, these substances were secreted into the intestinal lumen. This indicates that the jejunal mucosa of these patients was in a secretory state with respect to water and electrolytes.A method is presented for detecting abnormalities in the effective pore size in disease states. The method is based on the principle of restrictive diffusion and involves measuring the simultaneous diffusion rates of solutes of different molecular size. Since the method does not depend on measurement of water flow in response to osmotic pressure gradients, it can be used in disease states in which absorption and secretory processes involving water may be abnormal.The ratio of urea to tritiated water diffusion in the jejunum of normal subjects averaged 0.8, compared to 0.2 in patients with sprue. This indicates a marked decrease in the effective pore size of the jejunal mucosa in sprue. This conclusion was strengthened by the finding that erythritol and L-xylose, which are somewhat larger solutes than urea, are essentially non-absorbable in small bowel involved with sprue.


Nature of the renal concentrating defect in sickle cell disease. Free water reabsorption (T(c) (H2O)) measured during 10% mannitol diuresis and subsequently during 3% saline diuresis was compared in patients with sickle cell anemia and in normal subjects. During mannitol infusion, T(c) (H2O) progressively rose with increasing osmolar clearance (C(osm)) and reached a maximal level in both groups studied. During hypertonic saline diuresis, T(c) (H2O) progressively rose in the normal subjects and exceeded the maximal levels attained during mannitol diuresis, with no evidence of a maximal T(c) (H2O) level appearing. In contrast, none of the saline curves significantly exceeded the mannitol curves in the sickle cell patients but tended to parallel the mannitol curves at comparable rates of solute clearance. Since T(c) (H2O) is an index of both solute (sodium) transport from the loop of Henle and solute accumulation in the hypertonic medullary interstitium, tubular sodium handling was examined in both sickle cell patients and control subjects alike. No difference in the tubular transport of sodium could be demonstrated either under conditions of sodium loading or under conditions in which the tubular sodium load was low (water diuresis). These data support the conclusion that the defect in urinary concentration in sickle cell patients is caused by a limitation in maintaining a high concentration of solute in the medullary interstitium, thus limiting the rate of T(c) (H2O) from the collecting duct.


Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. Insulin secretory responses to paired intravenous and oral glucose loads were determined in 38 nonobese individuals classified as normal (nondiabetic) subjects, "mild" diabetics (fasting blood glucose below 105 mg per 100 ml), or "moderate" diabetics (fasting glucose below 192 mg per 100 ml). Studies were also performed in 29 obese persons who were similarly grouped. The intravenous load was given to assess the alacrity of hormonal release after glycemic stimulus, and the oral glucose to determine how the speed of initial insulinogenesis modifies the disposition of ingested carbohydrate. In the nonobese group, normal subjects responded to massive hyperglycemia after rapid injection of glucose with immediate and maximal outpouring of insulin, in contrast to a desultory insulinogenic response in patients with mild diabetes, and no initial response at all in moderate diabetics. During oral glucose tolerance tests, the much faster clearance of blood sugar in nondiabetic subjects was actually associated with lower absolute insulin output than was found in mildly diabetic patients, since the latter exhibited delayed hyperinsulinemia in concert with prolonged hyperglycemia. Moderate diabetics never showed excessive insulin release despite even greater hyperglycemia. An empirical "insulinogenic index," the ratio relating enhancement of circulating insulin to magnitude of corresponding glycemic stimulus, was used to compare the secretory capacities of respective groups. Despite the higher absolute hormonal output after oral glucose in mild diabetics, the index revealed that insulin release in normal subjects was proportionally more than twice as great. This relatively greater normal secretory response declared itself shortly after the administration of glucose by either route, and was maintained throughout both tests. In the 29 obese individuals, differences among groups were essentially the same as in persons of normal weight. Obese nondiabetics did show much larger absolute insulinogenic responses during both tests than did nonobese controls. Since corresponding glucose tolerance curves were also higher, the mean insulinogenic indexes for obese subjects were not statistically greater. Moreover, when comparable glucose curves of obese and nonobese controls


Peroxidative hemolysis of red blood cells from patients with abetalipoproteinemia (acanthocytosis). The effect of peroxidative stress on tissue was studied by exposure of red blood cells (RBC) from patients with abetalipoproteinemia to minute amounts of H(2)O(2)in vitro. Red blood cells from untreated patients showed a marked sensitivity to H(2)O(2), as evidenced by hemolysis and lipid peroxidation (peroxidative hemolysis). The appearance of lipid peroxidation products in sensitive cells after exposure to H(2)O(2) was indicated by 1) increases in the 2-thiobarbituric acid (TBA) reaction of trichloroacetic acid extracts, 2) increases in ultraviolet light absorbency of lipid extracts, and 3) decreases in polyunsaturated fatty acids. These changes were accompanied by a decrease in phosphatidyl ethanolamine and phosphatidyl serine in the RBC lipid extract. Similar lipid changes on exposure to H(2)O(2) were observed in the RBC from vitamin E-deficient rats. Treatment of the patients with d-alpha-tocopherol polyethylene glycol succinate by mouth, or addition of dl-alpha-tocopherol to the incubation medium protected the RBC from peroxidative hemolysis. Tocopherol appears to provide a primary biologic defense against peroxidative hemolysis. The presence of nitrite or carbon monoxide, which produced methemoglobin and carboxyhemoglobin, respectively, inhibited peroxidative changes, suggesting a catalytic role for oxy- or deoxyhemoglobin. Substances that prevented lipid peroxidation also prevented hemolysis; in addition, lipid peroxidation appeared to precede hemolysis. These observations suggested that hemolysis was a consequence of lipid peroxidation.


The effects of chronic hypoxemia on electrolyte and acid-base equilibrium: an examination of normocapneic hypoxemia and of the influence of hypoxemia on the adaptation to chronic hypercapnia. We have carried out balance studies in normal dogs in order to appraise the effects of chronic hypoxemia on acid-base and electrolyte equilibrium. During the first phase of observation we produced a state of "pure" hypoxemia by reducing the oxygen concentration (utilizing nitrogen as a diluent) and by adding carbon dioxide to the environment in a concentration sufficient to keep arterial CO(2) tension (PCO(2)) within normal limits. The data demonstrate that such a 9-day period of normocapneic hypoxemia has no effect on electrolyte excretion and is virtually without effect on plasma composition. During the second phase of observation we subjected the hypoxemic dogs to stepwise increments in arterial carbon dioxide tension in order to evaluate the effects of the low oxygen tension on the acid-base adjustments to a chronic state of hypercapnia. At least 6 days was allowed for extracellular composition to reach a new steady state at each level of inspired carbon dioxide. The data demonstrate a rise in both plasma bicarbonate concentration and renal acid excretion that was not significantly different from that which has been described previously for hypercapnia without hypoxemia. Just as in these earlier studies, plasma hydrogen ion concentration rose with each increment in carbon dioxide tension, each millimeter Hg increment in PCO(2) leading to an increase in hydrogen ion concentration of 0.32 nmole per L. It thus appears that the chronic"carbon dioxide response curve" is not significantly influenced by moderately severe hypoxemia.


The renal lesion associated with hemoglobinemia: a study of the pathogenesis of the excretory defect in the rat. The role of renal ischemia in the pathogenesis of the renal failure produced by hemoglobin injection in the rat is evaluated. The data indicate that in the initial hours of this lesion renal blood flow is consistently reduced and that during its subsequent evolution blood flow rises towards normal levels, in some animals, while inulin clearance remains severely depressed. Volume expansion during the initial stage of the lesion may effect a rise in renal blood flow to normal levels with little effect on inulin clearance rate, further demonstrating the relative lack of dependence of the excretory defect on concomitant renal ischemia. These observations indicate that renal ischemia is probably a necessary factor in the initial production of the lesion; that it persists during its initial phase, up to 24 hours in most rats; and that, although it may contribute to the observed excretory defect, it is not the predominant etiologic factor. Other functional data indicate that renal blood is perfusing nephrons in which the excretory capacity is impaired but which retain the ability to extract Diodrast from the peritubular capillaries. This functional pattern indicates an excretory defect secondary either to intratubular obstruction or to a primary reduction of glomerular filtration rate of undefined etiology. The morphological findings of numerous dense intratubular hemoglobin casts and, in the well-perfused kidney, dilatation of proximal tubules, are suggestive of an obstructive lesion. However, the data do not conclusively distinguish between these two pathogenetic mechanisms.


Uphill transport of urea in the dog kidney: effects of certain inhibitors. To study the renal medullary transport and accumulation of urea in dogs independent of water transport, we obliterated the medullary electrolyte gradient by a sustained ethacrynic acid diuresis. Infusions of urea were also given at various rates to vary urinary urea concentration. In the steady state, the kidneys were removed, and slices were analyzed for water, urea, and electrolytes. In every experiment in 15 dogs over a range of urinary urea concentration from 19 to 230 mmoles per L and urine flow from 0.5 to 9.7 ml per minute per kidney, an intrarenal urea gradient persisted, and urinary urea concentration was always lower than papillary water urea concentration. The magnitude of this uphill urinary-papillary gradient (mean +/- SE = - 21 +/- 2.9 mmoles per L) was not affected by hemorrhagic hypotension or a nonprotein diet. In 12 additional experiments begun similarly, inhibitors were infused into one renal artery. Both iodoacetate, an inhibitor of anaerobic glycolysis, and acetamide, an analogue of urea, markedly and significantly reduced both the intrarenal urea gradient and the uphill urinary-papillary gradient. In contrast, cyanide, an inhibitor of oxidative metabolism, had no observable effect on the urea gradients. The data are best explained by postulating an active transport system for urea in the medullary collecting duct deriving its energy from anaerobic glycolysis.


Studies on human platelet glycolysis. Effect of glucose, cyanide, insulin, citrate, and agglutination and contraction on platelet glycolysis. Evidence for a metabolically active plasma-free platelet system is presented. Glycogenolysis was found to be a potent pathway for lactate production. Aerobic glycolysis constituted a major fraction of glucose metabolized. Both insulin and cyanide increased lactate production in the presence of glucose. The Krebs cycle appeared to be operative for ATP synthesis when citrate was used as substrate. The first stages of gluconeogenesis were noted to be present. Glucose uptake contributed to increased lactate production.Thrombin, epinephrine, and ADP resulted in platelet agglutination and contraction and increased platelet glycogenolysis (phosphorylase activity). Epinephrine appeared to be a more potent activator of phosphorylase, resulting in a 70% increase in glucose 6-phosphate levels. Thrombin and epinephrine both increased glucose uptake and lactate production. Glucose uptake decreased in the presence of ADP. Except for incubations with epinephrine, glucose 6-phosphate remained constant under conditions in which lactate flux increased 3-fold and glucose uptake increased 2-fold. Thrombin, epinephrine, and ADP decreased ATP levels in the presence or absence of glucose.


Postural augmentation of plasma renin activity and aldosterone excretion in normal people. Peripheral plasma renin activity and aldosterone excretion rates have been measured in normal people during recumbency, recumbent exercise, tilting, and continuous ambulation. Upright posture induces a prompt elevation in peripheral plasma renin activity beginning in 15 minutes and peaking between 60 and 120 minutes. Aldosterone excretion is increased during 120 minutes of upright posture and correlates directly with the elevation in renin activity. Upright posture induces increased plasma renin activity regardless of the level of sodium intake in the preparatory diet. Concomitant measurements of endogenous creatinine clearance and the rates of excretion of sodium and potassium suggest that a fall in renal arterial perfusion resulting from upright posture induces increased release of renin and the subsequent secondary stimulation of aldosterone secretion. Our data indicate that the changes in plasma renin activity are due to changes in the amount of the enzyme rather than to changes in other elements of the reninangiotensin systm. This report discusses the physiologic importance of postural augmentation of renin production, emphasizing that for proper interpretation of values of plasma renin activity, posture as well as dietary factors must be considered and controlled.


Studies on auditory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids. Auditory thresholds for sinusoidal tones were determined in eight patients with adrenal cortical insufficiency (four with Addison's disease and four with panhypopituitarism) and compared to those in normal volunteers. In adrenal cortical insufficiency (ACI) the auditory detection sensitivity is significantly more acute than that of normal subjects over most of the frequency range, but especially in the region of greatest hearing sensitivity of normal subjects, 1,000 to 2,000 cycles per second (cps). Treatment of the patients with deoxycorticosterone acetate decreased serum potassium concentration and produced gains in body weight but did not alter auditory detection thresholds. Treatment with prednisolone or with maintenance doses of carbohydrateactive steroids returned the auditory detection threshold to normal in every patient tested.The mechanism by which carbohydrate-active steroids affect the sensitivity of the nervous system to sound is not known. However, since the senses of taste, smell, and hearing are all affected in similar fashion by their removal and replacement, there appears to be a generalized increase in sensitivity to all sensory stimuli in patients with ACI not receiving steroids. These hormones may play a significant role in maintaining the level of responsiveness of the sensory system to incoming stimuli.


Bacterial interference in chick embryos. Chick embryos infected intra-allantoically with nonvirulent staphylococci are protected from death due to infection with virulent staphylococci. The protection is associated with a delay in growth of the challenge strain and a delay in the production of toxic substances in the allantoic fluid. The protection is influenced by the number of bacteria in the protecting and challenge inocula and by the interval between the administration of the protecting and challenge strains. Protection cannot be transferred by administration of sterile filtrates of allantoic fluid in which the protecting strain has grown.


Portal blood flow in cirrhosis of the liver. Direct measurements of portal flow and pressure in a relatively large number of patients with cirrhosis show a marked reduction in flow associated with a nearly constant plateau of portal pressure. This lack of correlation indicates the complex relationships of resistances in the splanchnic, collateral, and hepatic circuits determining the division of the available splanchnic flow between the portal vein and the collateral pathways. Subtracting the measured portal flow from well-established estimates of total hepatic blood flow in cirrhosis suggests that the hepatic artery contributes more than one-half of the blood perfusing the cirrhotic liver. There was no instance of retrograde portal flow during the preshunt measurements, although such reversal was frequent after side-to-side portacaval anastomosis. Attempting to explain the plateau of portal pressure in the face of an increasing outflow resistance presumably associated with progress of the disease, we postulate that an augmented inflow resistance to the splanchnic chamber reduces splanchnic flow in cirrhosis. End-to-side portacaval anastomosis did not return normal portal flow, although it decreased pressure to accepted control levels. The assumption is that most of the splanchnic blood was flowing through the shunt, leading to a high splanchnic resistance in the immediate postshunt status. If this resistance was previously elevated, as suggested by the plateau of portal pressure, the mechanism responsible for the elevation was not immediately deactivated after the shunt, and the true effect of the operation upon splanchnic flow may not be measurable at such time. Respiratory oscillations were a significant component of portal flow in cirrhosis before and after portacaval anastomosis, indicating the limitations of any steady state analysis of the circulatory derangement in cirrhosis.


Prostaglandin content of amniotic fluid during pregnancy and labour.


Determination of distribution of diffusing capacity in relation to blood flow in the human lung. A method for appraising the distribution of diffusing capacity of the lungs (D(L)) in relationship to pulmonary capillary blood flow ([unk]Q(C)) in normal human subjects was derived from measurements of oxygen diffusing capacity (D(LO2)) and carbon monoxide diffusing capacity (D(LCO)) performed during breath holding. This method utilizes the fact that the observed D(LO2) is considerably reduced in value if uneven distribution of D(L) with respect to [unk]Q(C) (uneven D(L)/[unk]Q(C)) is present. In contrast, D(LCO) is barely affected by uneven D(L)/[unk]Q(C), and from its measured value one can calculate the value D(LO2) would have if no uneven D(L)/[unk]Q(C) were present (true D(LO2)). Once observed D(LO2) and true D(LO2) are known, the degree of uneven D(L)/[unk]Q(C) in the lung can be calculated. In five normal, resting, sitting subjects average values for true D(LO2) were 57 ml per (minute x mm Hg), and the directly measured D(LO2) was 33 ml per (minute x mm Hg). These values could be explained if one-half of total [unk]Q(C) were distributed to approximately 15% of total D(L). These measurements did not permit the determination of the alveolar to end capillary O(2) gradient, but calculations demonstrate that an important factor in determining its size may be the pattern of uneven D(L)/[unk]Q(C) present in the lungs. Estimations of the alveolar-end capillary O(2) gradient from measurements of D(LCO) or D(LO2) that do not take into account uneven D(L)/[unk]Q(C) may underestimate its size.


Incidentally discovered microscopic carcinoma of the prostate.


The induction of drug-metabolizing enzymes in rat liver during growth and regeneration. A biochemical and ultrastructural study.


Enzymes in blister fluid.

Enzymes in blister fluid.


Segregation of nucleolar components in mycoplasma-infected cells.


Lipid transport in liver. I. Electron microscopic identification of very low density lipoproteins in perfused rat liver.


Acute pancreatic necrosis induced by puromycin.


Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes.


Lymphocyte fine structure in the bursa of fabricius, the thymus, and the germinal centers.


Evolution of adrenal regeneration hypertension in rats with actively regenerating or fully regenerated glands.


Necrotizing polyarteritis in aging RF mice.


Active immunization in the pediatric age group.


Protein synthesis in epiphyseal cartilage. I. Incorporation rates and distribution of glycine-H3 and Na2S35O4 in vitro.


Current problems in the enteric infections.


Cholera: whither prevention?

Cholera: whither prevention?


Typhoid fever vaccine--yes or no?

Typhoid fever vaccine--yes or no?


The influence of age and nutrition on the incidence and control of enteric infections.


Immunoprophylaxis of arthropod-borne virus diseases.


Malaria: the changing outlook.

Malaria: the changing outlook.


The impact of vector-borne viral diseases in the Middle Atlantic States.


The rise in venereal disease: epidemiology and prevention.


The common cold: prospects for its control.


Tuberculosis and BCG.

Tuberculosis and BCG.


Epidemic influenza: immunization and control.


Clinical syndromes in adults caused by respiratory infection.


Role of mycoplasmas in human respiratory disease.


Current status of National Immunization Programs.


Community organization for immunization programs.


Arterial thrombus prevention and dissolution after low molecular weight dextran infusion in sheep.


Immunization for foreign travel.

Immunization for foreign travel.


Superficial thrombophlebitis.

Superficial thrombophlebitis.


Biochemical studies in phrynoderma (follicular hyperkeratosis). II. Polyunsaturated fatty acid levels in plasma and erythrocytes of patients suffering from phrynoderma.


Effect of daily MgO and vitamin B6 administration to patients with recurring calcium oxalate kidney stones.


Effect of ethanol on plasma glycerol in man.


Fasting plasma amino acids and nitrogen retention in man following prolonged supplementation with wheat gluten or egg whites.


Human zinc deficiency, endocrine manifestations and response to treatment.


Phenylketonuria. 3. Measurement of multiple parameters of liver function.


Tryptophan metabolism in women using steroid hormones for ovulation control. This is an extension of work recently reported by Rose regarding young women using a combination of progesterone and estrogen for ovulation control.  The 10 subjects studied had an abnormal xanthurenic acid excretion after a loading dose of tryptophan.  After treatment with 2.5 mg norethynodrel and .1 mg mestranol (Enovid-E) from Days 5 to 24 of the the cycle, 24-hour urine specimens were collected before and after administration of 2 gm of L-tryptophan.  They were then given 25 mg of pyridoxine hydrochloride 4 times a day during the 48 hours required to repeat the tryptophan loading test.  Controls were 18 healthy women not taking drugs.  Metabolites of trytophan determined were indican, anthranilic acid glucuronide, 0-aminohippuric acid, kynurenic acid, acetylkynurenine, kynurenine, 3-hydroxykynurenine, xanthurenic acid, and N-methyl-2-pyridone-5-carboxamide.  Urine specimines were analyzed for these and for 4-pyridoxic acid taking usual precautions to avoid dietary factors or drugs which might vitiate the results.  At first the ingestion of the steroid had no significant effect on the basal excretion of urinary tryptophan metabolites.  However, after the loading dose of tryptophan, the subjects taking Enovid E- excreted a mean level of 697 micro-moles of xanthurenic acid compared with a mean level of 29.8 micro-moles in controls.  Some of the other metabolites were also excreted in increased quantities: 3-hydroxykynurenine, kynurenine, kynurenic acid, and acetylkynurenine.  The others were excreted in normal quantities.  When experimental subjects were given 100 mg/day of supplemental pyridoxine hydrochloride, tryptophan metabolism was essentially normal.  These results should be considered in human metabolic studies of pyridoxine-requiring enzyme systems.


Excretion of vanilmandelic acid by obese women. Preliminary report.


Serum lipids, dietary factors and ischemic heart disease.


Quantitative estimation of diets to control serum cholesterol.


Sugar intake and myocardial infarction.

Sugar intake and myocardial infarction.


Hormonal stimulation of Necturus gastric mucosa in vitro.


Influence of isobaric and hyperbaric oxygen on biliary PO2 and the mechanics of bile flow.


Temporary coronary occlusion in conscious dogs: collateral flow and electrocardiogram.


Effects of epinephrine and norepinephrine on the mesenteric circulation of the cat.


Inotropic augmentation of myocardial oxygen consumption.


Influence of hypoxia on mean circulatory pressure and cardiac output.


Intracellular pH of the human lymphocyte.


Interactions of gram-negative bacterial endotoxin with rabbit blood in vitro.


Blood platelets and heparin-induced lipolytic activity.


Effect of glucose, phlorizin, and parathyroid extract on renal phosphate transport in chickens.


Transport mechanisms for renal tubular excretion of creatinine in the chicken.


Effect of DCA and Na intake on mice bred for high and low juxtaglomerular indices.


Effect of altered cardiac metabolism and work on lipoprotein lipase activity of heart.


Effect of fluoride administration on plasma fluoride and food intake in the rat.


Turnover of lactic acid in normal and diabetic dogs calculated by two tracer methods.


Insulin secretion in hypothermic dogs.

Insulin secretion in hypothermic dogs.


Ovarian function in pigs following hypophysial stalk transection or hypophysectomy.


Exchange of albumin between blood, cerebrospinal fluid, and brain in the cat.


Deoxy-D-glucose and cyanide depression in Xenopus single medullated nerve fibers.


Aberrations of regulation in ground squirrels following hypothalamic lesions.


Elastic components of cat papillary muscle.


Chemical basis for the [H+] gradient across frog skin.


Tidal volume in CO2 regulation: peripheral denervations and ablation of area postrema.


Function of the excretory system of the crocodile (Crocodylus acutus).


Roentgenologic studies of the alimentary tract in kwashiorkor.


Energy sources for gastric secretion: substrates.


Roentgenologic features of a primary carcinoma of the liver in infants and children.


Hepatic uptake and excretion of Hg197 chlormerodrin used for renal scanning.


Achondroplasia.

Achondroplasia.


Primary hyperoxaluria; roentgenographic, clinical and pathologic findings.


Roentgen findings in homocystinuria.

Roentgen findings in homocystinuria.


Roentgenological evaluation of bladder neck obstruction.


Roentgenographic evaluation of late results of ileal loop urinary diversion in infants and children.


An unusual case of neonatal hydrometrocolpos.


Congenital stenosis of medullary spaces in tubular bones and calvaria in two proportionate dwarfs--mother and son; coupled with transitory hypocalcemic tetany.


Pleuropulmonary pseudotumors in childhood.


Intrathoracic neuroblastoma.

Intrathoracic neuroblastoma.


Hodgkin's disease in children.

Hodgkin's disease in children.


Development-radiologic reevaluation: an overview.


Skeletal changes in the Cornelia de Lange syndrome.


Turner's syndrome and pseudo-Turner's syndrome.


The roentgenographic features of the oto-palato-digital (OPD) syndrome.


Cleidocranial dysostosis: some atypical roentgen manifestations.


Progressive osteolysis in progeria.

Progressive osteolysis in progeria.


Significance of the muscle cylinder ratio in infancy.


The newborn skull: the diagnosis of fracture.


The failure of surgeons as scientists.

The failure of surgeons as scientists.


Acalculous cholecystitis.

Acalculous cholecystitis.


Primary carcinoma of the gallbladder. Review of fifty-two cases.


Thromboelastographic evaluation of the method of heparin administration.


Thrombophlebitis after vena caval clipping.


Prognostic significance of cancer cells in the circulating blood. A ten year evaluation.


Clinical and experimental use of gelatinized dacron grafts.


Division of the left renal vein as an adjunct to resection of abdominal aortic aneurysms.


Sequential angiographic observations on internal mammary implants.


Ovarian tumors in infants and children.

Ovarian tumors in infants and children.


Unusual presacrococcygeal cystic tumors.


An appraisal of the role of surgical face masks.


Spontaneous fistula between the aorta and left renal vein.


Resection of the extracranial internal carotid aneurysm.


Post-traumatic external pancreatic fistula.


Hereditary chronic relapsing pancreatitis. A clue to pancreatitis in general?


Acute arthritis. A complication of surgically induced hypoparathyroidism.


Hematoma of the liver discovered one year after injury.


Obstruction of the colon. A rare sequel to partial gastrectomy.


Late development of colonic carcinoma complicating ureterosigmoidostomy.


Partial mandibular replacement with a silicone strut.


Suction drainage of the subhepatic area after cholecystectomy.


An automatic cartridge stapler.

An automatic cartridge stapler.


Exploration of the common bile duct with Van Buren sounds.


Is destructive surgery ever necessary for treatment of thyroid cancer in children?


Bronchial adenoma and the carcinoid syndrome.


Anatomic etiology and operative treatment of peptic esophagitis: an experimental study.


Surgical considerations in the management of achalasia of the esophagus.


Benign stricture of the esophagus secondary to gastroesophageal reflux.


The persistent left superior vena cava. Surgical implications, with special reference to caval drainage into the left atrium.


Surgical management of the tetralogy of Fallot: influence of a previous systemic-pulmonary anastomosis on the results of open correction.


Experiences with the treatment of 59 patients with lower esophageal web.


Coarctation of the abdominal aorta with renal arterial stenosis: surgical considerations.


Aorto-iliac reconstruction without preoperative aortogram.


Salvage of arteriosclerotic legs by vascular repair.


Surgical treatment of iliofemoral thrombosis.


Phlegmasia cerulea dolens: an experimental study.


Sleep and depression. A follow-up study.


The depressed woman returns. A study of posthospital adjustment.


LSD and psychiatric inpatients.

LSD and psychiatric inpatients.


Sleep and electroconvulsive therapy.

Sleep and electroconvulsive therapy.


The generality of specificity.

The generality of specificity.


The court-appointed psychiatrist. His role in the commitment of the mentally ill person.


Some riddles of riddance. Relationships between eliminative processes and emotion.


The diagnostic evaluation process. A follow-up of 49 children studied in an outpatient clinic.


The good therapy hour. Experiential correlates of patients' and therapists' evaluations of therapy sessions.


The doctor's personality and social recovery of schizophrenics.


The pattern of anaesthesia in a general hospital.


The use of computers in clinical trials.


Physics applied to anaesthesia. 8. Ionizing radiations.


Drug treatment centres.

Drug treatment centres.


Ataxia and myxoedema.

Ataxia and myxoedema.


Dermal ridges and rubella.

Dermal ridges and rubella.


Health of university students.

Health of university students.


Glomerular filtration rate.

Glomerular filtration rate.


Uveoparotitis.

Uveoparotitis.


Attitudes to smoking.

Attitudes to smoking.


Effect of prostaglandin E1 on platelet behaviour in vitro and in vivo.


Disorders of the outflow tract of the left ventricle.


Vi reaction in Hong Kong.

Vi reaction in Hong Kong.


The thymus in systemic lupus erythematosus: a quantitative histopathological analysis and comparison with stress involution.


Heparin administration by constant infusion pump.


Use of the Quinton/Scribner arteriovenous shunt in management of aplastic anaemias.


Medical aspects of divorce and nullity of marriage.


Skeletal metastases from cerebellar medulloblastoma.


Centres for treatment of drug addiction. Advantages of special centres.


Centres for treatment of drug addiction. Treatment in the community.


Centres for treatment of drug addiction. Importance of research.


Collection and handling of medical data.


The family--changing patterns of medical care.


Centres for treatment of drug addiction. Integrated approach.


Reports on gentamicin.

Reports on gentamicin.


Basic medical education.

Basic medical education.


Electrical anaesthesia.

Electrical anaesthesia.


Consequences of tobacco research.

Consequences of tobacco research.


Total replacement of the knee.

Total replacement of the knee.


Public health dispute.

Public health dispute.


Better conditions of service.

Better conditions of service.


Clinical, manometric, and pathological studies in diffuse oesophageal spasm.


Normal confinement: a domiciliary and hospital study.


Dosage of gentamicin for pseudomonas infections.


Gentamicin and colistin in chronic purulent bronchial infections.


Parenteral administration of gentamicin in renal failure: patients undergoing intermittent haemodialysis.


Effect of mental stress on the fibrinolytic reactivity to exercise.


Hypophysitis and hypopituitarism: report of a case.


Radioactive isotopes in clinical medicine. II.


Fatal case of Pasteurella pseudotuberculosis infection associated with hepatic cirrhosis.


Babies at risk.

Babies at risk.


Health centres and the general medical practitioner.


Decentralizing administration.

Decentralizing administration.


Tenovus.

Tenovus.


Epidemiology of head injuries in children: a pilot study. A retrospective study of children with head injuries and head lacerations in an active emergency department (Vancouver General Hospital) revealed differences in incidence with age and sex, as well as relationships between the frequency of visits and the season, the day of the week and the time of day. Radiographs were taken of a large number of the patients with head injuries and a significant proportion of these children were admitted to hospital.A prospective study is proposed which would examine the natural history of accidental head injuries in children.


Hospital emergency services for children and adolescents: a one-year review at the Vancouver General Hospital. The records of visits of children and adolescents to the emergency department of the Vancouver General Hospital were reviewed during the period July 1, 1965, to June 30, 1966, and the diagnostic and disposal data recorded. One-quarter of all visits were made by children and adolescents. Three-quarters of the visits were made for surgical conditions. There were more males than females in both surgical and medical groups, and the peaks in attendance were of those in the early preschool and late adolescent age groups. Three-quarters of the patients were referred to the family doctor and approximately one-sixth were admitted to the hospital. These findings suggested that while prompt medical attention was usually indicated, the majority of problems were not urgent and that the emergency department was becoming a substitute for the office of the family physician.


Hemihypertrophy and medullary sponge kidney.


Another look at pulmonary embolism.

Another look at pulmonary embolism.


The positive tuberculin test.

The positive tuberculin test.


Attrition of students from Canadian medical schools.


The education of orthopedic surgeons in the University of British Columbia.


Pneumonia in Indian and Eskimo infants in Canada.


Left ventricular contraction and the therapy of cardiogenic shock.


A hemodynamic study of left ventricular aneurysm.


Arteriolar abnormalities with chronic systemic hypertension. A quantitative study.


An autopsy study of leg vein thrombosis.


Histochemical studies of the myocardium and conduction system in acquired iron-storage disease.


Basal lamina of abdominal skeletal muscle capillaries in diabetics and nondiabetics.


Digital arteriography in occlusive arterial disease and clubbing of the fingers.


Distensibility characteristics of the human pulmonary vascular bed. Study of the pressure-volume response to exercise in patients with and without heart disease.


Relation of body weight to development of coronary heart disease. The Framingham study.


Effect of aminophylline on urinary excretion of epinephrine and norepinephrine in man.


Chronic primary chylopericardium. Report of a case and review of the literature.


Bilateral bundle-branch block. Clinical and electrocardiographic aspects.


Correction of total anomalous pulmonary venous drainage in infancy utilizing deep hypothermia with total circulatory arrest.


Evolution of corrective surgery for Ebstein's anomaly.


Surgical correction of tetralogy of Fallot with previous systemic to pulmonary artery shunts.


Results of operation for atrial septal defect in patients forty-five years of age and older.


Adjustable prosthesis for pulmonary artery banding. Comparison with umbilical tape and teflon bands.


Surgical significance of angiographic patterns in coronary arterial disease.


"Demand" and internal mammary artery implantation.


Combined prosthetic replacement of the mitral and aortic valves. Preoperative and postoperative hemodynamic studies at rest and the left ventricular response to muscular exercise.


Application of gas endarterectomy to atherosclerotic peripheral vessels and coronary arteries. Clinical and experimental results.


Operative therapy for femoral-popliteal arterial occlusive disease. A comparison of therapeutic methods.


Follow-up studies of acute dissecting aortic aneurysms managed with antihypertensive agents.


Relative evaluation of left heart bypass, whether pulsatile or pulseless, with counterpulsation as technique for myocardial augmentation.


Effect of total cardiopulmonary bypass on human lung elastic properties.


Effect of airway hypocapnia on mechanics of breathing during cardiopulmonary bypass.


Influence of oxygen flow rate on arterial oxygenation and acid-base balance during cardiopulmonary bypass with use of a disc oxygenator.


Pulmonary compliance following open-heart surgery and its relationship to ventilation and gas exchange.


Sublethal damage to the red blood cell from pumping.


Hemodynamic results with full-flow orifice prosthetic valves.


Effects of induced ventricular fibrillation on ventricular performance and cardiac metabolism.


Exercise tolerance and hemodynamic studies after replacement of canine mitral valve with and without preservation of chordae tendineae.


A nonthrombogenic, nonanticoagulant-dependent mitral valve prosthesis.


Early clinical experience with homotransplantation of the aortic valve.


Surgical treatment of cardiac defects associated with corrected transposition of the great vessels.


Conservative management of tricuspid regurgitation in patients undergoing mitral valve replacement.


Factors affecting thromboembolism associated with prosthetic heart valves.


Late postoperative pathological findings after cardiac valve replacement.


Influence of rhythm and anticoagulation upon the incidence of embolization associated with Starr-Edwards prostheses.


Cardioversion after mitral valve operations.


A survey of the current status of pulmonary embolectomy for massive pulmonary embolism.


Abbreviation of the glucose tolerance test.


Correlation of serum and urine enzyme activity in patients with acute myocardial infarction.


Determination of serum calcium by automated atomic absorption spectroscopy.


Early results of use of homografts for replacement of the aortic valve in man.


Porphyrin patterns in different types of porphyria.


Interference by formaldehydogenic drugs in the quantitative determination of urinary hydroxyindoleacetic acid.


Stability of plasma enzymes during storage.


Recalibration of the Gilford absorbance indicator.


Psycho-social prescription for music therapy in hospitals.


Observations on the relationship of tranquilization effects and alterations of blood sedimentation values.


Schizophrenia, oligospermia, and the phenothiazines.


Autobiography of a transsexual. (Ten years as a woman).


Hysterical blepharospasm.

Hysterical blepharospasm.


Chromatographic analysis of biologically active lipids from rabbit irides.


Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract.


Epithelial potential of the cornea.

Epithelial potential of the cornea.


The isolation of whole cells from the ciliary epithelium together with some observations on the metabolism of the two cell types.


Experimental degeneration of the rabbit retina induced by sodium fluoride. An electron microscope study.


Action of cyclodialysis utilizing an implant studied by manometry in a human eye.


Solute movement across the constituent membranes of the cornea.


A note on bioluminescence as measured by Tarusov and its non-contrinution to entoptic phenomena.


Observations on corneal potential.

Observations on corneal potential.


Effects of transcranial electric currents on intraocular and cerebrospinal fluid pressures.


Quantitation of lower esophageal sphincter competence.


Fiberoptic and conventional esophagoscopy in the diagnosis of esophageal varices. A comparison of techniques and observers.


A routine method for the gas chromatographic determination of pregnanediol.


Origin of follicle cells in the infant mouse ovary.


Correlation of serum L-phenylalanine-sensitive alkaline phosphatase, derived from intestine, with the ABO blood group of cirrhotics.


Comparative effects of gastrin II and histamine on pepsin secretion in man.


Transport of radioactive iodine (I-131) to the vaginal lumen and genital tract of the rat.


Intestinal transport of sodium, potassium, and water in the dog during sodium depletion.


Lysosomal injury in murine viral hepatitis.


Intestinal absorption of essential amino acids in man.


Secretion of calcium by the canine pancreas.


Perforation of an esophagogastric anastomotic ulcer into the left atrium. Case report and review of the literature.


Modified uterine sound for placing sperm in the uterine cavity.


Effect of wheat proteins in celiac disease.


A simple technic of hysterography for evaluating side effects and mode of action of intrauterine devices. A study of 100 cases. This paper describes the use of a simple technique of hysterography to evaluate the side effects and mode of action of IUD.  The technic utilizes 2 x-ray films per patient of the lower abdomen:  a flat film to determine the presence or absence of the device, and a hysterogram; diluted water-soluble contrast medium was used, allowing visualization of the device and the endometrial cavity in a single x-ray exploration.  The technic was performed on 100 women fitted with Lippes loop; 74 of these experienced side effects while 22 patients with no complaints were used as controls; 1 had an asymptomatic uterine peforation with the loop lying in the pelvis and 3 were pregnant (2 had a double uterus).  In the control group, the hysterograms were performed 3-6 months after loop insertion while in the study group, the hysterogram were done 3-190 days after insertion, with the exception of true expulsion cases where a device similar to that ejected was reinserted just before taking x-ray.  44 patients were found to have bilateral cornual spasm.  Incomplete fundal coverage of the device was associated with an increase in the incidence of side effects, mainly bleeding.  Out of 23 cases of clinically suspected expulsion, the device was found in situ in 12 cases.  In 10 cases, the IUD position was reversed with the thread withdrawn into the uterine cavity.  In the remaining 2, the loop was found in the abdominal cavity.  Congenital uterine abnormality was also found in 4 out of 10 cases with true expulsion.  The incidence of side effects can be minimized by constructing IUDs which would fit properly into the endometrial cavity.  Hysterography is a useful diagnostic tool for determining the incidence of side effects and possible mode of action of IUDs; it can also provide an index of the probable efficiency of the device after insertion.


In-vitro studies of oxytocin and motility of guinea pig uterus and vagina.


The postcoital test and semen analysis.

The postcoital test and semen analysis.


Assessing the strength of a sphincter.

Assessing the strength of a sphincter.


Biologic determinants of birth intervals in mice.


Renal artery disease: treatment and results.


Nontuberculous complications of pulmonary tuberculosis.


Refractory heart failure.

Refractory heart failure.


Mental health services for older people.


Recognizing the potential suicide.

Recognizing the potential suicide.


Catheter perforation of the ventricle after intracardiac pacing.


The vesicorenal reflex.

The vesicorenal reflex.


Pharmacologic evaluation of ureteral smooth muscle. A technique for monitoring ureteral peristalsis.


Long term effects of unilateral vesical denervation in a canine bifid bladder preparation.


The use of 99mTc labeled sulfur colloid to study particle dynamics in the urinary tract. Vesicoureteral reflux.


Correlation of renal hemodynamics, metabolism, and erythropoietin release in hemorrhagic hypotension and the response to chlorpromazine treatment.


A direct effect of antiovulatory compounds on human testicular biosynthesis in vitro. Human testes, removed in treating patients for prostatic carcinoma, were used.  Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4  ,9(10)-androstadiene-17beta-ol-3-one).  Further biochemical procedures are described.  Results show that the compounds added in vitro to the homogenates inhibited the conversion of progesterone to 17alpha-hydroxyprogesterone, 20alpha-hydroxy-4-pregnene-3-one, and androgens.  It is thought that these 2 compounds exert a direct effect on the activity of 2 human testicular enzymes related to the biosynthesis of androgens and on the 20alpha-hydroxy steroid dehydrogenase.  With the concentrations employed, no androgen biosynthesis was observed with the larger doses and only partial inhibition with the smaller doses.  The action could be on the enzyme systems themselves or on the synthesis of the enzymes.  Results are valid for in vitro conditions only.


Localized heating of tissue by electric and nonelectric means.


The normal range of renal size in children.


Electrolyte determinations in normal, denervated, and defunctionalized dog bladders.


Approaches to teaching adults.

Approaches to teaching adults.


"Program aides" for work with low-income families. 1. Use of a home economics program aide.


"Program aides" for work with low-income families. 2. Developing a training program for program aides.


"Program aides" for work with low-income families. 3. Developing leaflets for working with families.


"Program aides" for work with low-income families. 4. Pilot study in Alabama.


A short dietary method for epidemiologic studies. 1. Developing standard methods for interpreting seven-day measured food records.


Food habits of the valley people of Laos.


Studies on human antibodies. V. Amino acid composition of antidextrans of the same and of differing specificities from several individuals. Human dextran-antidextran-specific precipitates from individuals immunized with dextrans containing either one or two antigenic determinants, were analyzed for their content of various amino acids. Large differences in certain amino acids were found among alpha-(1 --> 6)-specific antidextrans. Wide variations were also observed in antidextran fractions from a given individual specific for alpha-(1 --> 6)- and alpha-(1 --> 2)-linked glucose residues.


Studies on cyclophosphamide-induced tolerance to sheep erythrocytes. Complete immunological tolerance to sheep cells can be induced in mice when cyclophosphamide is injected together with sheep cells or up to 72 hr before or 48 hr after the antigen. As is true for radiation-induced immune suppression, the drug is most effective when given in the 24 hr prior to antigen. Complete cyclophosphamide-induced immunological suppression requires large doses of sheep cells (6.2 x 10(9) cells), presumably to enable antigen to reach sequestered receptor sites. The cyclophosphamide tolerance system has been analyzed with the Jerne technique to determine plaque-forming cells and with isotopic methods to measure rates of nucleic acid synthesis. This drug suppression has been found to consist of two components. The first is nonspecific injury to the lymphoid system caused by the cytotoxic drug and is related to the proportion of spleen cells killed. The second is antigen-specific immunological tolerance and appears to correlate with profound depression of deoxyribonucleic acid synthesis in the surviving cells. This tolerance is thought to be most consistent with a mechanism in which antigenic stimulation in the presence of cyclophosphamide-inhibited DNA synthesis and mitosis leads to the elimination or death of the specific immunological clone. Tolerance induction with cyclophosphamide is associated with loss of the 19S hemolysin plaques which are seen in nonstimulated mouse spleen, implicating these cells in immune responsiveness. The ability to induce tolerance is lost on the 3rd postantigen day at the end of a 24-hr period in which 19S cells have increased 8-fold and 7S cells 200-fold. The data suggest that loss of sensitivity is due to the emergence on day 3 of drug-resistant plaque-forming cells, particularly those of the 19S variety. In the succeeding days after antigen injection there is a progressive increase in the resistance of plaque-forming cells to cyclophosphamide administration.


Electron microscopic studies of normal and abnormal elastic fibers of the skin.


Quantitative studies of phytohemagglutinin-induced DNA and RNA synthesis in normal and agammaglobulinemic leukocytes. Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.


Morphologic changes induced by methotrexate. Histologic studies of normal and psoriatic epidermis.


Nerve stimulation and the movement of melanin granules in the pigment cells of the frog's web.


Peroxidase activity in normal and neoplastic melanocytes.


Dermo-epidermal separation with suction. Electron microscopic and histochemical study of initial events of blistering on human skin.


Spontaneous and experimental hair growth of the mouse pinna.


Plasma torch reactions in the skin.

Plasma torch reactions in the skin.


Electron microscope observations of the fine structure of Microsporum gypseum.


Absence of formaldehyde sensitivity in phenol-formaldehyde resin dermatitis.


Receptor organs of the human palmar skin over cicatrical neuroma.


Radioiodine uptake studies of the human fetal thyroid.


Non-dialyzable manganese and copper levels in serum of patients with various diseases.


Comparison of adsorption of iodine-131-thyroxine to glass and plastic containers.


Energy absorption in cylinders containing a uniformly distributed source.


Technetium-99m as a label for erythrocytes.


Carotid artery occlusion due to nonpenetrating injury.


Uptake of selenomethionine by mouse and in human lymphomas, with observations on selenite and selenate.