Unorthodox repair of a vesico-cervical fistula.


Maternal acid-base changes in pregnancy.


Shirodkar sling operation in the treatment of genital prolapse.


Dysgerminoma with atypical, mixed gonadal dysgenesis. A case report with chromosomal investigation of patient and tumour.


A light and electron microscope study of cells in contact with intrauterine contraceptive devices.


Carcinoma corpus following cystic glandular hyperplasia in a young woman.


Marfan's syndrome and pregnancy.

Marfan's syndrome and pregnancy.


Renal infection in pregnancy. II. Bacteriuria in pregnancy related to maternal factors.


Pregnancy and delivery after mitral valvotomy.


The incidence and significance of vasculo-syncytial membranes in the human placenta.


The unfavourable cervix and induction of labour using a cervical balloon.


The value of urinary oestriol estimation in patients with antepartum vaginal bleeding.


Effect of foetal movements on foetal heart rate.


Blood loss in obstetrics using a haemoglobin dilution technique.


Pneumococcal meningo-encephalitis in pregnancy.


Chorionic gonadotrophin in the serum and urine of Asian women in normal pregnancy.


Malignant transformation in ovarian endometriosis.


The effect of metronidazole therapy on cervical histology in trichomoniasis.


A ring D chromosome and anomalous inheritance of haptoglobin type.


Prezygotic determinants in acute leukemia.


The reserve albumin binding capacity as a criterion for exchange transfusion.


The selective hemolytic action of drugs: clinical and mechanistic considerations.


Serum ionic magnesium in exchange transfusion.


Cerebral lesions in congenital rubella syndrome.


Translocation in trisomy D syndrome. A case of a probable D/18 translocation.


Regulation of body temperature of premature infants with low-energy radiant heat.


A method for long-term quantitative and fractional urine collection.


Hematuria associated with methicillin therapy.


A rapid method for estimation of salicylate in serum.


Sixth National Burn Seminar. Use of gentamicin sulfate in burn therapy.


Migraine.

Migraine.


Sixth National Burn Seminar. Control of burn wound sepsis with topical therapy.


Sixth National Burn Seminar. Special burn problems. Gastrointestinal ulceration.


Sixth National Burn Seminar. Treatment of burned patients by physical means.


Sixth National Burn Seminar. Bleeding in children.


Sixth National Burn Seminar. The effect of growth hormone on the burn patient.


Sixth National Burn Seminar. Nutrition in burns.


Sixth National Burn Seminar. Sympatho-adrenal medullary response to thermal injury.


Sixth National Burn Seminar. Adrenaline and noradrenaline excretion following burns.


Sixth National Burn Seminar. Metabolic problems in burned patients. Evaporative water and heat loss.


Sixth National Burn Seminar. Summarizing remarks.


Sixth National Burn Seminar. Recent developments in the anesthetic management of burned patients.


A false aneurysm of the popliteal artery due to physical exercise. Report of a case.


Saline-irreversible tourniquet shock in germfree, ex-germfree and conventional mice.


Central rupture of the liver with lobar infarction. A unique problem requiring urgent right hepatic lobectomy.


Combat casualty management in Vietnam.

Combat casualty management in Vietnam.


Physiochemical and metabolic effects of low molecular weight dextran in oligemic shock.


Sixth National Burn Seminar. Introductory remarks.


Sixth National Burn Seminar. Fluid therapy. Introduction to fluid therapy.


Sixth National Burn Seminar. Fluid therapy using colloid.


Sixth National Burn Seminar. A guide for fluid therapy in burn patient management.


Superior mesenteric artery division and intestinal function.


Sixth National Burn Seminar. Management of sepsis.


Sixth National Burn Seminar. Electrical burns.


Sixth National Burn Seminar. Control of Pseudomonas infections by the immune processes.


Adolescence and antisocial behaviour.

Adolescence and antisocial behaviour.


The modern physician.

The modern physician.


Strangulated femoral hernia.

Strangulated femoral hernia.


The employment of dialysis in general hospitals and in artificial kidney units.


Orbital decompression after facial fractures.


A medico-psychiatric diagnostic review of remanded (without a request for a psychiatric report) male minor offenders.


A flowering calendar of possible hay fever plants in Brisbane.


Aversion therapy in early alcoholism.

Aversion therapy in early alcoholism.


A case of duodenal ulcer in an infant.

A case of duodenal ulcer in an infant.


Post-operative biliary peritonitis.

Post-operative biliary peritonitis.


Vertebral artery compression in cervical spondylosis.


Hafnia: an unusual cause of postoperative gram-negative bacteriae.


Blunt trauma to the thorax: management of a case of haemopericardium and cardiac tamponade.


"Ritalin" and "sodium amytal": an alternative to L.S.D. 25 as an adjunct to psychotherapy.


Radioisotopes in medicine. 1. Introductory physics.


Total body water and total body density of pregnant women.


Paracervical block anesthesia for dilatation and curettage.


Hodgkin's disease of the uterine cervix. Report of a case.


Postpubertal oogenesis following Co60 irradiation in the albino rat.


Amniography, an accurate way to localize the placenta. A comparison with soft-tissue placentography.


Diffuse intravascular coagulation associated with a degenerating myoma during pregnancy.


Maternal death from puerperal sepsis following cesarean section. A 16-year study in Michigan.


Locked twins. Report of 3 cases.

Locked twins. Report of 3 cases.


Intrascrotal hyperthermia induced by scrotal insulation: effect on spermatogenesis.


Metronidazole treatment of vaginal trichomoniasis. II. Oral vs. vaginal therapy.


Eisenmenger's complex and pregnancy.

Eisenmenger's complex and pregnancy.


Biochemical survey of protein sufficiency during pregnancy in urban women.


Pregnancy before and after surgical correction of left-to-right cardiovascular shunts.


Simple surgical treatment for condyloma acuminatum of the vulva.


Interruption of pregnancy for psychiatric indication--a suggested method of control.


Prelabor pelvic score as a predictor of birth weight.


Tetracycline-induced hepatic coma, with recovery. Report of a case.


A simple technic for shortening the clitoris without amputation.


Pregnancy in the rabbit and antibodies to human menopausal gonadotropin.


The safety of clinical ultrasonic examination. Electroencephalographic examination of the neonate subjected to pulsed ultrasound.


Colpotomy as a definitive operation in ectopic pregnancy.


An improved piper forceps.

An improved piper forceps.


Multiple cesarean section.

Multiple cesarean section.


Maternity care in low-income families.

Maternity care in low-income families.


Milk-like fluid in a mammary adenocarcinoma: biochemical characterization. The milk-like accumulation in the R3230AC mammary adenocarcinoma that follows treatment with estrogen contains lactose, fatty acids, and proteins with electrophoretic properties similar to those of casein and whey of rat milk. This mammary tumor retains the biochemical capacity of the mammary gland in its lactational response to administration of hormone.


Evolution of immunoglobulins: structural homology of kappa and lambda Bence Jones proteins. The amino acid sequence of a human lamba chain has been determined. There are many identities in sequence with human kappa chains, but this intraspecies homology is less than the interspecies homology of kappa light chains of man and mouse. Structural relationships suggest a common evolutionary origin and early differentiation of light- and heavy-chain genes.


Leukocyte oxidase: defective activity in chronic granulomatous disease. The intact leukocytes of two children with chronic granulomatous disease fail to reduce nitroblue tetrazolium during phagocytosis. This is due to defective operation of an oxidase of reduced nicotinamide adenine dinucleotide that is insensitive to cyanide and that indirectly stimulates the oxidation of glucose-6-phosphate in leukocytes. Such leukocytes undergo no increase in oxygen consumption or in activity of the hexose monophosphate shunt during phagocytosis, although lactate production is normal. The addition of nitroblue tetrazolium to a leukocyte suspension appears to provide a sensitive diagnostic screening test for this disease.


Synaptic noise as a source of variability in the interval between action potentials. The source of variability in the interval between action potentials has been identified in a class of cat spinal motoneurons. The observed random fluctuations in membrane potential (synaptic noise) together with an empirical description of spike generation accurately predict the statistical structure of variability observed to occur in the neuron's discharge.


Honey bees: do they use the direction information contained in their dance maneuver? Direction communication experiments, when controlled against unilateral visitation of trained foragers at the experimental site, exhibited no evidence supporting the precision of communication suggested in the dance "language" hypothesis. Results compare well with those which might be expected on the basis of the geometric arrangement of the feeding dishes.


Honey bees: do they use the distance information contained in their dance maneuver? Regular visitors at one site (experimental) in a linear series of sites normally recruit inexperienced hive mates to or near that site. If bees from a second hive were allowed to forage at both control sites, however, recruits from the experimental hive, while orienting to these sites, exhibited no evidence of having used any distance information they might have received before leaving their parent hive.


Reserpine and hypothalamic mediation.

Reserpine and hypothalamic mediation.


The effect of intranasal oxytocin on the pregnant uterus.


Pathogenesis of eccentric fixation.

Pathogenesis of eccentric fixation.


Management of infantile cataracts.

Management of infantile cataracts.


Carcinoma of the sigmoid and rectum: selection of operative procedure.


Clinical studies of induction agents. XVII. Relationship between dosage and side effects of intravenous barbiturates.


Performance of the Portablease and the Fluoxair portable anaesthetic equipment: with reference to use under adverse conditions.


The treatment of psoriasis with methotrexate.


The treatment of vitiligo with psoralens and triamcinolone by mouth.


Alterations in cellular sodium, potassium, calcium, magnesium, copper and zinc levels during the development and maturation of erythrocytes in the rabbit.


Hereditary elliptocytosis: a report of two families from new guinea.


Factor-8 (antihaemophilic factor) activity in sickle-cell anaemia.


Platelets in haemostasis and thrombosis.


New anticoagulant from lysed fibrinogen.


The factor-8 activity in fresh and stored plasma.


The anaemia of erythropoietic porphyria. II. Studies of some red-cell intermediates.


Peripheral mercury embolization occurring during arterial blood sampling.


Vitamin B-12 absorption by inhalation.

Vitamin B-12 absorption by inhalation.


Modified balloon catheter.

Modified balloon catheter.


Prolapsed cord.

Prolapsed cord.


Poisoning with mandrax.

Poisoning with mandrax.


Response of the A-V node of the rabbit to stimulation of intracardiac cholinergic nerves.


Catecholamine metabolism in experimental hypertension in the rat.


Diabetes in an infant following inapparent mumps.


Treatment of respiratory infections in children with methacycline. Observations on therapeutic results and toxicity.


Prolonged mild meningococcemia in an infant.


The nephrotic syndrome: current concepts in diagnosis and therapy advantages of alternate day steroid regimen.


Ureteral reflux in children. Concepts for conservative vs surgical treatment.


From the Massachusetts General Hospital hypoglycemia in infancy. Appraisal of the problem, methods of investigation, possible association of cataracts.


The influence of innervation on the soluble proteins of slow and fast muscles of the rat.


The lateral reticular nucleus of the medulla oblongata of the cat.


The processes affecting the distribution of bromide in blood, brain, and cerebrospinal fluid.


The kinetics of the two-step interaction of chymotrypsin with proflavin.


Type-specific polysaccharide antigens of group B streptococci. II. The chemical basis for serological specificity of the type II HCl antigen. The type-specific antigen of Group B Type II streptococci has been prepared free of other known cell components. This antigen is a capsular polysaccharide containing D-galactose, D-glucose, N-acetyl-D-glucosamine, and a labile component which has not been chemically characterized. Extraction of Type II streptococci with cold TCA yielded this antigen which contained two serological determinants. A partial antigen with only one of the determinants was obtained by extraction with dilute HCl at 100 degrees C. By means of the quantitative precipitin inhibition technique, a (beta-D-galactopyranoside has been established as the determinant of the HCl-extracted polysaccharide. The second determinant, present solely in the TCA antigen, has not been identified.


The metabolism and function of urocanic acid in skin.


Catecholamine-induced mast cell discharge with anaphylactoid purpura.


Enhancement of dinitrochlorobenzene (DNCB) contact sensitization by cyclophosphamide in the guinea pig.


Ovulation detection utilizing hemagglutination inhibition reaction. Preliminary studies.


Early morphological changes produced by anti-inflammatory steroids on tissue culture fibroblasts.


Cell-free protein synthesis in mammalian skin.


Mechanism of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration.


Cryogenic temperature studies of human skin. Temperature recordings at two millimeter human skin depth following application with liquid nitrogen.


Tissue clearance: what it does measure.

Tissue clearance: what it does measure.


Separation of alcohols of human hair lipids by thin layer and gas chromatography.


Effect of ascorbic acid on certain blood fat metabolism factors in animals and man.


Free choice consumption of spiced diets by rats.


Thiamine deficiency, infantile manipulation and startle response in rats.


Influence of dietary fat and protein on metabolic and enzymatic activities in adipose tissue of meal-fed rats.


Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents.


Thyroid and pituitary pathology in iodine-deficient rats fed fresh and oxidized fats and oils.


Pyruvate metabolism in thiamine-deficient calves.


Utilization by the rat of 1,3-butanediol as a synthetic source of dietary energy.


Effect of vitamin E deficiency on collagen metabolism in the rat's skin.


Symposium on modern management of respiratory diseases. Foreword.


Comparative studies of the metabolism of 14C-pyrimidine-labeled thiamine, 14C-thiazole-labeled thiamine and 35S-labeled thiamine in the rat.


Treatment of arteriosclerotic complications, gangrene, and infection in diabetic patients.


Clinical aspects and hemodynamics of pericardial diseases.


Treatment of pericarditis associated with systemic disease.


Treatment of infectious pericarditis.

Treatment of infectious pericarditis.


Treatment of chronic constrictive pericarditis.


Treatment of resistant diabetes mellitus.


Treatment of the postpericardiotomy syndrome, pericarditis of acute myocardial infarction, and postinfarction syndrome.


Ultrasound as an adjunct in the treatment of pericardial effusion.


Treatment of pericarditis in children.

Treatment of pericarditis in children.


Surgical treatment of pericardial disease.


Treatment of diabetic neuropathy.

Treatment of diabetic neuropathy.


Treatment of diabetic retinopathy and oculopathy.


Treatment of diabetic nephropathy.

Treatment of diabetic nephropathy.


Treatment of skin diseases associated with diabetes.


Diabetic lipemia. A form of acquired fat-induced lipemia.


Hemolytic anemia in Wilson's disease.

Hemolytic anemia in Wilson's disease.


An in-training examination for residents as a guide to learning.


Dehydration in infants and children.

Dehydration in infants and children.


Case records of the Massachusetts General Hospital. Case 8-1967.


Renal hypertension. Diagnosis and surgical treatment.


Hemodynamics in the cirrhotic patient during paracentesis.


Potentiation of anticoagulant effect of warfarin by phenylbutazone.


Technical assault and battery.

Technical assault and battery.


Case records of the Massachusetts General Hospital. Case 9-1967.


Case records of the Massachusetts General Hospital. Case 10-1967.


Metabolic activities of sloughed cells from the jejunal mucosa of dogs with Thiry-Vella loops.


Enhancing effect of type specific antistreptococcal antibodies on emergence of streptococci rich in M-protein.


Transmission of Marek's disease with oral washings and feces from infected chickens.


Cancer of the breast as a familial disease.


Role of thymectomy in the management of myasthenia gravis.


Demonstration of typical hemochromogen formation in clinical shock.


Gustatory sweating following parotid surgery and radical neck dissection.


Gunshot wounds of the thoracic aorta with peripheral embolization of the missile: a case report.


Metastasizing carcinoma of the stomach in Peutz-Jeghers syndrome.


Extracranial carotid aneurysms: treatment by excision and end-to-end anastomosis.


Aortic valvular insufficiency associated with cystic medial necrosis: surgical and pathologic considerations.


Percutaneous transhepatic cholangiography.


Role of early laparotomy in acute pancreatitis.


Obstruction of the pancreatic duct by ligature in the treatment of pancreatitis.


Clinical significance of primary hyperplasia of gallbladder mucosa.


Diagnostic peritoneal lavage in blunt abdominal trauma.


Mucocele of the appendix with pseudomyxoma peritonei: a benign or malignant disease?


Wounds of the abdomen: radiographic diagnosis of intraperitoneal penetration.


An ideal bedside commode for the rehabilitation ward.


Electromyography and nerve conduction studies in 116 patients with hemiplegia.


Nerve conduction studies in hemiplegia.

Nerve conduction studies in hemiplegia.


Physiatry--both art and science.

Physiatry--both art and science.


A method of electromyographic kinesiology of the thumb.


Experience with cutaneous vesicostomy for paraplegics and quadriplegics.


Electrophysiologic studies in chronic occlusive peripheral vascular disease.


Peripheral nerve injections with phenol in the management of spastic patients.


Electrocardiogram in Asiatic cholera. Separated studies of effects of hypovolaemia, acidosis, and potassium loss.


Anatomically corrected transposition of the great arteries.


Perforation of peptic ulcer complicating myocardial infarction.


Histology, extensibility, and chemical composition of pulmonary trunk in persons living at sea-level and at high altitude in Peru.


Heart failure with brain damage in the newborn.


Relation of plasma renin to blood pressure in a patient with coarctation.


Coronary artery--right ventricular fistula treated surgically.


Congenital "absence" and anomalous origin of the main pulmonary arteries. Variations of the same congenital defect.


The electrocardiogram in chronic lung disease.


A lead system designed to record proximity effects on the praecordial electrocardiogram.


Aneurysm of the membranous ventricular septum.


Double outlet right ventricle with pulmonary stenosis.


Congenital heart disease with arrhythmia in a family.


Congenital mitral stenosis.

Congenital mitral stenosis.


Experience in the surgical treatment of patients with common atrio-ventricular canal.


Coronary embolism.

Coronary embolism.


Sex of athletes.

Sex of athletes.


Rheumatoid lungs and rheumatoid piles.

Rheumatoid lungs and rheumatoid piles.


Radical bladder surgery.

Radical bladder surgery.


Commonwealth links.

Commonwealth links.


Strokes and fits.

Strokes and fits.


Glycosuria in pregnancy.

Glycosuria in pregnancy.


Referring the patient.

Referring the patient.


Influenza.

Influenza.


Post-hemiplegic epilepsy in the elderly.


Identification of "Ryan Virus" as an amoeba of the genus Hartmannella.


Outcome of medically treated stroke associated with stenosis or occlusion of the internal carotid artery.


Haemolysis in typhoid fever in children with G-6-PD deficiency.


Massive pulmonary embolism.

Massive pulmonary embolism.


A case of osteomalacia, osteoporosis, and hypercalcaemia.


Tybamate.

Tybamate.


Management of cutaneous lupus erythematosus.


Postgraduate surgical education.

Postgraduate surgical education.


Mental subnormality as a specialty.

Mental subnormality as a specialty.


Photographing jejunal biopsy specimens.

Photographing jejunal biopsy specimens.


Citadels?

Citadels?


The many faces of "ulcerative colitis".

The many faces of "ulcerative colitis".


Drinking induced by electrical stimulation of the lateral hypothalamus.


Inhibition of monosynaptic and polysynaptic reflexes and muscle tone by electrical stimulation of the cerebral cortex.


Interaction of peripheral and central input in the main sensory trigeminal nucleus of the cat.


Effect of carbon dioxide on the cortical seizure threshold to lidocaine.


Cancer of the rectum and colon. Review of 2,402 personal cases.


Estrogens and the liver.

Estrogens and the liver.


Evaluation of ligation of hemorrhoids as an office procedure.


Acetylcholine and 5-hydroxytryptamine levels of the lateral geniculate bodies and superior colliculus of cats after visual deafferentation.


Electrophysiological correlates of saccadic suppression.


The indigenous flora of the gastrointestinal tract.


Alcohol and the fine structure of the liver.


Radical colectomy for carcinoma of the colon.


Regional colitis.

Regional colitis.


Treatment of ulcerative colitis with hydrocortisone alcohol retention enemas: a topical and systemic anti-inflammatory agent. II.


Ileorectal anastomosis for ulcerative colitis.


Medium chain triglycerides and the Van de Kamer method.


The indirect method for estimating the gastric acid response to normal solid food.


The pharmacological similarity of pylorus and antrum.


Roentgen therapy for regional enteritis?


Immune inhibition of urea breakdown in patients with cirrhosis.


Choleresis induced by stimulation of the gastric antrum.


Intrinsic factor secretion in response to continuous histamine infusion.


Early fine structural changes in the human liver induced by alcohol.


A method for detecting impaired local blood flow in the intact intestine.


Clearance of circulating radiochromated albumin and erythrocytes by the gastrointestinal tract of normal subjects.


Lactase activity before and after acute febrile bacterial illness.


Effect of aminopterin on the absorption of fat into the lymph of unanesthetized rats.


A secretin test with high doses of secretin and correction for incomplete recovery of duodenal juice.


Uveitis (iritis) associated with ulcerative and granulomatous colitis.


Leiomyosarcoma of the bile ducts.

Leiomyosarcoma of the bile ducts.


Treatment of chronic skin ulcers by a proteolytic enzyme-antibiotic preparation.


Mechanisms leading to hypoventilation in extrapyramidal disorders, with special reference to Parkinson's disease.


Some factors associated with absence of coronary heart disease in persons aged 65 or older.


Spontaneous regression of malignant disease: report of three cases.


Acute peptic ulcer in the elderly: similarity to stress ulcer.


Laboratory studies on the aging kidney.

Laboratory studies on the aging kidney.


Effects of imipramine in elderly incontinent psychiatric in-patients.


Individualized versus mass transfer of nonpsychotic geriatric patients from mental hospitals to nursing homes, with special reference to the death rate.


Short-term learning and memory efficiency as a function of age and health.


Fifty aging men: a demonstration project in social services to psychiatric geriatric patients.


The family group therapy program at Park View Home for the Aged.


Deprivation dwarfism.

Deprivation dwarfism.


A postural sign in the sensory deprivation syndrome in infants.


Congenital chylous ascites: lymphangiographic demonstration of obstruction of the cisterna chyli and chylous reflux into the peritoneal space and small intestine.


The effects of exogenous aldosterone on sweat electrolytes. I. Normal subjects.


The effects of exogenous aldosterone on sweat electrolytes. II. Patients with cystic fibrosis of the pancreas.


Acute pulmonary coccidioidomycosis in children.


Evaluation of sedation during cardiac catheterization of children. Analysis of PaO2, PaCO2, pH, and base excess determinations during hemodynamic investigation.


Growth in children with congenital heart disease.


Hemodynamic effects of arteriovenous oxygenation with a small-volume artificial extracorporeal lung.


Estrogen excretion during the first 24 hours of life. Estrogen-creatinine ratio.


Atrial septal defect associated with pulmonary hypertension in children living at high altitude.


An infant scale guard.

An infant scale guard.


Silver's syndrome: report of a case with chromosomal and dermatoglyphic study.


Corneal opacities resulting from xerophthalmia.


Another view of statistics.

Another view of statistics.


Renal artery aneurysms: their diagnosis and endocrine implications: a case report in a child.


Bilateral renal arteriovenous fistulas and decreased blood pressure following renal biopsies.


Hippuran I-131 renography and clearance measurements used for determination of the individual kidney function.


Radiologic aspects of renal trauma with the emphasis on arteriography and renal isotope scanning.


Renal scan: the test of choice in renal trauma.


Progressive renal fibrosis following acute tubular necrosis: an experimental study.


Renal papillary necrosis: a critique of pathogenesis.


Transitory erythrocytosis induced by unilateral, partial ligature of a renal vein in dogs.


U-tube nephrostomy.

U-tube nephrostomy.


Hypernephroma metastasis in the lung with no demonstrable primary tumor.


Pelvic retroperitoneal lymphoid hamartoma.


Determination of ureteral pressures in the intact dog.


Loop pyeloplasty: a new technique.

Loop pyeloplasty: a new technique.


Spontaneous rupture of the ureter.

Spontaneous rupture of the ureter.


Successful treatment of post-radiation ureteral stricture by simple linear incision.


Use of the Davis nylon loop extractor for removal of low ureteral calculi.


The incidence of vesicoureteral reflux in the premature child.


The effect of cryogenic freezing of the dog bladder.


Treatment of bilharzial-contracted bladder by ileocystoplasty or colocystoplasty.


Observations with electrocystography.

Observations with electrocystography.


Characteristics of bladders reconstructed from intestine covered with vesical mucosa.


The results of urethroplasty using a silicone rubber patch.


Sites of deposition of tritium labeled tetracycline in induced rat bladder tumors and ulcers: a preliminary study.


Penile horn: review of literature with 3 case reports.


Rupture of the dorsal artery of the penis as a result of sexual intercourse.


Testicular torsion in the newborn: report of a case.


The histology and prognosis of prostatic cancer.


External irradiation: a successful modality in preventing hormonally induced gynecomastia.


Spermatic granuloma of the epididymis.

Spermatic granuloma of the epididymis.


Treatment of uric acid urolithiasis with allopurinol: a xanthine oxidase inhibitor.


Allopurinol control of hyperuricosuria: a new concept in the prevention of uric acid stones.


Studies on urolithiasis. IX. The effect of dimethyl sulfoxide in the control of urinary calculi.


Urine beta glucuronidase activity in urinary tract disease.


Diarrhoeal disease in Papuan infants and children.


Anencephalus: a 23-year survey in a Sydney hospital.


B663 in treatment of atypical tuberculous disease.


A cancer detection service for working women, with a report on the first 1,000.


Moles and malignant melanoma: terminology and CLASSIFICATION.


The origins of the practices of circumcision and subincision among the Australian aborigines..


Hypnosis and anxiety as conditioned reflex responses.


Asthma and aerosol sprays.

Asthma and aerosol sprays.


A study of the natural history of cerebral vascular disease.


Bromism induced by "safe" medications, old and new: some psychological considerations.


Ventricular fibrillation and competitive pacing.


Severe postoperative hyperbilirubinemia simulating obstructive jaundice.


Diagnostic usefulness and safety of transtracheal aspiration.


Replantation of an infant's arm.

Replantation of an infant's arm.


Thrombogenesis.

Thrombogenesis.


Replantation--problems solved and unsolved.


The spectrum of jaundice.

The spectrum of jaundice.


Methisazone in progressive vaccinia.

Methisazone in progressive vaccinia.


Potassium therapy.

Potassium therapy.


Postoperative massive liver necrosis. A clinical and pathological study.


Biology of tendon repair.

Biology of tendon repair.


Hyperglycemia and hyperosmolarity in an eighteen-month-old child.


Erythropoiesis in patients with renal failure undergoing chronic dialysis.


The nature of the alpha-methyldopa red-cell antibody.


Anemia and renal disease.

Anemia and renal disease.


New aspects of diabetic coma.

New aspects of diabetic coma.


Case records of the Massachusetts General Hospital. Case 13-1967.


Polyostotic fibrous dysplasia with a high FSH.


Stomatocytosis.

Stomatocytosis.


Malignant melanoma: Regression of metastases after excision of primary growth.


Bilateral chylothorax with multiple osteolytic lesions? Generalized abnormality of lymphatic system.


Prepyloric and pyloric mucosal stenosis (4 cases).


Organochlorine insecticides and wildlife populations.


Hereditary peripheral dysostosis (three cases).


Human exposure to organochlorine pesticides.


Injuries to the cervical spine.

Injuries to the cervical spine.


The orthopaedic bladder.

The orthopaedic bladder.


The post-natal development of the hip-joint.


Haemarthrosis and haemophilia.

Haemarthrosis and haemophilia.


The work of the hospital rehabilitation officer.


The kidney in hypertension: studies with radioactive chlormerodrin.


Dilution anaemia associated with enlargement of spleen.


Cardiac resuscitation--clinical and metabolic studies.


Studies on blood keto acids in vitamin deficiency.


Leiomyosarcoma of the intestine presenting with melaena.


Angina pectoris and the prospective study.


Some uses of prospective observations in the Tecumseh Community Health Study.


An unusual case of myositis ossificans.

An unusual case of myositis ossificans.


Tonometry.

Tonometry.


Automatic visual field tests.

Automatic visual field tests.


Amputation of the lower limb for ischemic disease.


Electrodiagnosis tests in ophthalmology.


Psoriatic arthropathy.

Psoriatic arthropathy.


An improved indifferent electrode in surgical diathermy.


The function of mucus: a hypothesis.

The function of mucus: a hypothesis.


Intravenous infusion techniques.

Intravenous infusion techniques.


Mucus in respiratory disease.

Mucus in respiratory disease.


Exchanges across cell membranes.

Exchanges across cell membranes.


A chemist's view of cancer prevention.

A chemist's view of cancer prevention.


Osteomyelitis of the spine.

Osteomyelitis of the spine.


Again, classical versus molecular biology studies.


Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory. It is apparent that antibiotics are useful in differentiating different stages in the formation of memory. Puromycin gave the first indication that very early memory can be established and survive, for a short period at least, in spite of inhibition of protein synthesis (12). Injection of actinomycin D indicates that RNA synthesis is not essential during this early stage (13). The duration of this early period seems to vary with the inhibiting agent; with puromycin memory was notably degraded in less than an hour, but with actinomycin D or with acetoxycycloheximide it persisted for several hours or more. The fixation or consolidation of memory involves whatever processes give permanence to memory. These processes are disrupted when electroconvulsive shock is administered shortly after a learning experience, presumably because of the interference with organized patterns of neuronal electrical activity. Memory acquired in the presence of antibiotics appears to proceed to a stage beyond that based purely on electrical activity because the memory persists beyond the period usually reported as sensitive to electroconvulsive shock. Further work should show whether this stage is truly insensitive to electroconvulsive shock. Memory acquired in the presence of puromycin does not seem to achieve any durable consolidation. In contrast, memory acquired in the presence of or immediately before injection of acetoxycycloheximide does appear to initiate the later stages of consolidation, as permanent memory. reappears some days after the initial stages have become ineffective in controlling performance. Finally, puromycin has provided evidence of the enlarged area of the neocortex which participates as memory matures. Puromycin also indicates the time required for this maturation process. Since antibiotics have also been useful in studying learning and memory in goldfish (14), this approach seems to have general applicability in defining various stages in the process of memory formation. The initial purpose of these investigations was to determine the molecular basis of the "memory trace" This goal still remains distant, although there are some indications that protein synthesizing systems are involved. This objective, though of enormous interest, is to be regarded as only a necessary first step. Whether new proteins or some other molecules cause the changes in synapses thought to underlie memory, this knowledge of itself will contribute only a beginning to our understanding of the events which account for the functioning of the brain. A determination of the composition of computer components would provide very little information towards unraveling their function. As the experiments proceeded, however, information of a more general nature was being obtained. The identification of different stages of consolidation show how injections of antibiotics can supplement electroconvulsive shock as a way of disrupting the establishment of memory and how it can supplement ablation in destroying memory already laid down in a permanent mode. Applied to larger animals the localization of various regions sensitive or insensitive to the action of the drugs should become more definitive. We hope that such experiments will contribute increasingly to the general problem of brain function.


Basic and applied research: a meaningful distinction?


Single fallout particles and zirconium-95 from the Chinese nuclear explosion of 9 May 1966. Daily fluctuations of the number of single fallout particles and activity of zirconium-95 in the groundlevel air were measured at Fayetteville (94 degrees W, 36 degrees N), Arkansas, for a period of about 3 months after the Chinese nuclear explosion of 9 May 1966. We found a cyclic pattern of variations for both zirconium-95 and fallout particles; this indicated that they were airborne for a long period and traveled far. Apparently, some of the particles circled the world more than once.


Chromosomal damage in human leukocytes induced by lysergic acid diethylamide. Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.


Amino acid transport: evidence for genetic control of two types in human kidney. A mutation affecting renal transport of proline, hydroxyproline, and glycerine occurs in man. In the presumed homozygote there is still significant residual transport of these compounds; however, this remaining function is saturated at normal concentrations of substrate in the plasma and is not inhibited by L-proline in the expected way. The presumed heterozygote has partial loss of a transport system common to the three substrates, which becomes saturated at high concentrations of substrate and is inhibited by L-proline. Two different types of transport systems are proposed: a common system and systems with lower capacity and greater specificity. The two types of transport appear to be controlled by separate genes.


Ecological dosimetry: radiation levels influenced by plant growth. The feasibility of using lithium-7-fluoride thermoluminescent dosimeters under field conditions for natural radiation at levels of 5 milliroentgens is demonstrated. Radiation dosages in tree trunks increased threefold from winter to spring and summer. This increase is attributed to the gamma radiation field resulting from relatively high levels of potassium-40 and other radionuclides present in the foliage and branches during the growing season.


Lysine transport in human kidney: evidence for two systems. Experiments with slices of human kidney cortex from two control subjects demonstrated two distinct transport systems for lysine (alpha and beta) which differ greatly in affinity and capacity. Both systems were found in kidney from two patients with cystinuria. Studies with rat kidney confirmed these findings. These experiments defined only a single transport system for cystine in kidney from both control and cystinuric subjects.


Giant-cell centrioles.

Giant-cell centrioles. The giant cell of osteoclastic origin and the giant cell produced in response to foreign bodies are characterized by multiple nuclei. Electron microscopy of these multinucleated cells reveals a special centrosphere in the osteoclast, which is not typical of other types of giant cells.


Radio tracking of homing bats.

Radio tracking of homing bats. Neotropical bats, Phyllostomas hastatus, were released 10 kilometers from their home roost, and their homeward flights were tracked by radio. Flights of bats with unimpeded vision were strongly oriented in the homeward direction, while the flights of blindfolded bats did not show this marked orientation.


Information delivery and the sensory evoked potential. The waveform of evoked responses recorded from human scalp is not determined solely by the physical eliciting stimulus, but also varies as a function of the effective information provided by the stimulus. There is a positive component whose latency is determined by the point in time at which ambiguity is reduced, and whose shape and amplitude are influenced by whether it is the presence or absence of an external event which delivers the information.


Mental retardation.

Mental retardation.


Effects of visual form on the evoked response. The average visual evoked potentials elicited from relaxed human subjects are different for a blank visual field and one containing a geometric form, are different for different geometric forms of equal area, are similar for versions of the same geometric fortn of unequal area, and are different for two printed words equated for total letter area. These findings suggest that the waveform of evoked responses is not determined solely by the set of peripheral receptors which is stimulated, but it also reflects the perceptual content of the stimulus.


An experimental and clinical study of cross ureteroureterostomy.


Implantation in cancer of the colon.

Implantation in cancer of the colon.


Management of cervical spine dislocations with locked facets.


Factors influencing the viscosity of blood.


False aneurysms in the lower extremity.

False aneurysms in the lower extremity.


The association of diaphragmatic hiatal hernia and gastroesophageal carcinoma.


Subungual melanoma.

Subungual melanoma.


Umbilical vein catheterization in man.

Umbilical vein catheterization in man.


Problems of wound infections.

Problems of wound infections.


The role of the industrial nurse re-examined.


Technique of abdominoperineal resection of the rectum.


Degrees of mental illness.

Degrees of mental illness.


The fear of radiation.

The fear of radiation.


The nurse in the chemical industry.

The nurse in the chemical industry.


Logland: a Gibbsian view of acid-base balance.


All nurses should be counselors.

All nurses should be counselors.


The distinctive electrocardiogram of Duchenne's progressive muscular dystrophy. An electrocardiographic-pathologic correlative study.


Familial paroxysmal rhabdomyolysis in children. A myoglobinuric syndrome.


Type B botulism in man.

Type B botulism in man.


A sixty-three year old woman with fulminant meningitis and convulsions.


Granulomatous sarcoid nephritis.

Granulomatous sarcoid nephritis.


Angiokeratoma corporis diffusum universale (Fabry's disease) in female subjects.


The straight back syndrome. Another cause of innocent systolic murmurs.


RNA metabolism and protein synthesis in plasma cell leukemia.


Treatment of Wegener's granulomatosis with Imuran.


An aneurysm of the anterior tibial artery. A case report.


The syndrome of mechanical occlusion of the vertebral artery: further observations.


The effect of quinidine on experimental competitive cardiac pacing.


Vascular permeability in experimental brain tumors.


Angiographic and hemodynamic studies of angiokinetic phenomena in dogs.


The biologic consequences of hypercholesteremia in man and its treatment.


Electrocardiographic changes during left heart and aortic angiocardiography with urografin 76 percent and isopaque 60 percent.


Organization and administration of Westminster-Moorfields Eye-Bank.


Modern treatment of severe "shrinkage of the conjunctiva".


Variations in the normal electro-oculogram.


Gonioscopy and artefacts.

Gonioscopy and artefacts.


Cytological survey of conjunctival smears from aboriginal school children at Yalata, South Australia.


Microcornea with myopia.

Microcornea with myopia.


Rhinosporidium granuloma of the conjunctiva.


The detection of disease clustering and a generalized regression approach.


Malignant lymphoma of the orbit with generalized metastases.


Primary (methylcholanthrene-induced) fibrosarcomas and glycoprotein synthesis.


Effect of vitamin A on 7,12-Dimethylbenz(alpha)anthracene-induced papillomas in rhino mouse skin.


Cell morphology of a human diploid cell strain (WI-38) after treatment with arabinosylcytosine.


Radiosensitivity of drug-resistant L1210 leukemia.


Electron microscopic studies on a human fibromyxosarcoma.


Kidney cell proliferation after unilateral nephrectomy as related to age.


Hydroxyurea: effects on Chinese hamster cells grown in culture.


The role of periodic and interrupted treatment of newborn and infant mice with urethan on leukemogenesis.


Relationship of uptake and binding of an antileukemic phthalanilide to its biochemical and chemotherapeutic effects on P388 lymphocytic leukemia cells.


Effect of the N1-oxides of adenosine, 2'-deoxyadenosine, and 3'-deoxyadenosine on tumor growth in vivo.


Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.


Homograft rejection by neonatally thymectomized germ-free mice.


The organ distribution of disseminated 51 Cr-labeled tumor cells.


On the phagocytizing activities of Ehrlich ascites tumor cells.


Influence of heparin upon the resin uptake of 131-I-L-thyroxine from serum.


Circulatory responses to breath holding in man.


Metabolism of 17-alpha-estradiol-6,7-3H by nonpregnant women.


Use of sodium fluoride in the treatment of osteoporosis.


Enteric excretion of metabolites of steroid hormones in the human subject. V. Isolation of  5-alpha-pregnane-3-alpha,20-alpha-diol from meconium.


Effect of pyrogen on blood levels of pituitary trophic hormones. Observations of the usefulness of the growth hormone response in the detection of pituitary disease.


The "taste" test in adrenal insufficiency.


Studies on steroid conjugates. V. Urinary 17-hydroxycorticosteroids in essential hypertension.


Comparative effects of caloric restriction and metabolic acceleration on body composition in obesity.


Radioimmunoassay for human follicle-stimulating hormone.


The use of rheomacrodex in the surgery of intracranial aneurysms.


Aneurysms of the posterior cervicocranial circulation: clinical and angiographic considerations.


A new form of congenital adrenal hyperplasia.


Angiographic identification of the motor strip.


Evaluation and indications for surgery in extracranial cerebrovascular disease.


An arterial posterior fossa extradural hematoma demonstrated by vetebral angiography. Case report.


Anterior third ventricular cysts in infancy. Case report.


Hydrocephalus due to dilatation of the dural sinuses. Case report.


The physician and the computer.

The physician and the computer.


The seminar method for the treatment of disability. I. Experiences of an industrial physician.


The effect of halothane on intracranial pressure in cerebral tumors. Report of two cases.


The seminar method for the treatment of disability. II. Experiences of an internist.


The seminar method for the treatment of disability. 3. Factors in the doctor-patient relationship.


There is much to be done.

There is much to be done.


Visual acuity.

Visual acuity.


Threshold limit values.

Threshold limit values.


Poisoning by parathion.

Poisoning by parathion.


Electrocardiographic changes in children following extubation.


Studies in alcoholism. I. A general hospital medical clinic for the treatment of alcoholism.


Is exercise necessary for the obstetric patient?


Hennessy WB: Simple gastric ulcer--a radiological survey.


Ventilatory capacity in a series of male adults and the effect of respiratory symptoms, productive cough, smoking habit and occupation.


Heart disease in the territory of Papua-New Guinea: a preliminary report based on a necropsy study.


The diet in phenylketonuria.

The diet in phenylketonuria.


The use of the "Medihaler" as an aid to bacteriological diagnosis in pulmonary tuberculosis.


Background music during radiotherapy.

Background music during radiotherapy.


General anesthesia for dental work in Queensland.


The problems of drug addicts.

The problems of drug addicts.


Modified septal reconstruction for deflected nasal septum.


A record system for CSSD.

A record system for CSSD.


How drugs act--second series. 7. Drugs and the colon.


Immunization by nurses in the home.

Immunization by nurses in the home.


CSSD and the nurse.

CSSD and the nurse.


Neurosurgery today. 6. Spinal cord surgery.


Aseptic techniques.

Aseptic techniques.


Clinical instruction. 3. The clinical instructor herself.


Libraries for nurses. Fulham and Charing Cross group of hospitals.


Wertheim's hysterectomy: a nursing care study.


Rehabilitation and resettlement--they're different.


How drugs act--second series. 8. Drugs and cancer.


Evening infant welfare clinic.

Evening infant welfare clinic.


Rehabilitation of patients with neurological deficit.


Social therapy for the elderly blind.

Social therapy for the elderly blind.


Drugs in hospital.

Drugs in hospital.


Salmon--and the problems of administration.


Young minds at risk; NAMH conference.

Young minds at risk; NAMH conference.


Complications of abortion.

Complications of abortion.


Rehabilitation of patients with neurological deficit. 2.


Drugs in hospitals; conference at The Hospital Centre.


Self-care at Kingseat Hospital, Newmachar.


Whittington Hospital: new site for the nursing school.


Preparation for parenthood.

Preparation for parenthood.


Acute appendicitis in pregnancy.

Acute appendicitis in pregnancy.


Acceptance of pregnancy before and since oral contraception.


Parental smoking empirically related to pregnancy outcome.


The Birnberg bow as an intrauterine contraceptive device.


Tetraethylammonium ions: effect of presynaptic injection on synaptic transmission. Tetraethylammonium ions were injected into the presynaptic axon of the squid giant synapse. Injection of these ions caused prolongation of the action potential with decreased out ward current. The prolonged spike was associated with increased release and prolonged activity of the transmitter substance. Although the amplitude of the postsynaptic potential increased with presynaptic depolarization, strong depolarization blocked transmitter re lease. In the injected presynaptic axon, transmitter release was blocked by 10(-6) gram of tetrodotoxin per milliliter. Transmitter release appears to be under control of presynaptic potential levels.


Muscarine: isolation from cultures of Clitocybe rivulosa. Muscarine has been iso lared in a yield of 0.013 percent from mycelia of Clitocybe rivulosa grown in the laboratory on a medium supple mented with beer wort. Its reineckate and aurichloride derivatives were pre pared.


Ribosomes: effect of interferon on their interaction with rapidly labeled cellular and viral RNA's. Rapidly labeled RNA of mouse L cells and labeled RNA of Mengo virus, unlike cellular RNA labeled under steady-state conditions, form detectable complexes with L-cell ribosomes. These ribosome-RNA complexes formed in vitro appear analogous to those assembled during polysome formation in vivo. When ribosomes are prepared from L cells exposed to homologous interferon, their capacity to associate with cell messenger is preserved, while their ability to interact with viral RNA is markedly reduced. The ribosomes from cells exposed to interferon are thus altered selectively to permit only certain messages to be bound and translated.


Collagen-coated cellulose sponge: three dimensional matrix for tissue culture of Walker tumor 256. Three-dimensional growth of large populations of cells in vitro has been observed in the interstices of a matrix consisting of collagen-coated cellu lose sponge. The growth of Walker tumor 256 in this composite matrix is com pared with that found in a matrix composed of either cellulose sponge alone or collagen sponge alone. The composite matrix is superior to either one. Collagen coated cellulose sponge may provide a simple tool for the study of social interaction of cells in the formation of organized elementary tissue structures.


D-glucose: preferential binding to brush borders disrupted with tris(hydroxymethyl)aminomethane. The actively transported sugar D-glucose binds to brush borders disrupted with tris(hydroxymethyl)aminomethane in preference to D-mannose and L-glucose, which are not actively transported. This preferential binding of D-glucose is not dependent on either added Na(+) or adenosine triphosphatase activity stimulated by Na(+) with K(+) and Mg(2+), but it is temperature-dependent and is completely inhibited by 0.1 millimolar phlorizin and 1 millimolar mercuric chloride.


Ciguatoxin: isolation and chemical nature. Ciguatoxin, the agent responsible for ciguatera, a disease produced in humans from ingestion of certain fishes, has been isolated from specimens of the moray eel, Gymnothorax javanicus. The toxin is apparently a lipid containing quaternary nitrogen, hydroxyl, and carbonyl functions.


Functional chloroplast polyribosomes from tobacco leaves. Incubation of isolated to bacco chloroplasts with ingredients re quired for protein synthesis resulted in liberation of 70S ribosomnes and poly ribosomes that no longer sedimented with the chloroplasts. With increasing time of incubation, polyribosomes broke down to 70S monosomes. Similarly, microgram quantities of ribonuclease caused chloroplast polyribosomes to break down into monosomes. Both polyribosomes and 70S ribosomes that were isolated on sucrose density gra dients and tested separately in cell-free systems were capable of protein syn thesis; however, polyribosomes formed more protein per unit of RNA than monosomes did.


Orientation by taste in fish of the genus Ictalurus. Fish of the genus Ictalurus can find distant chemical clues by means of taste alone, and they exhibit true gradient searching in the absence of a current. Neither unilateral nor bilateral deprivation of the sense of smell impaired their searching ability, but unilateral deprivation of taste receptors which are spread over body and barbels of the animals caused pro nounced circling toward the intact side. The relation of swimming paths of the fish to the chemical in the water suggested that comparisons of concentrations were made in time and space.


Thyroxine: effects of neonatal administration on maturation, development, and behavior. Thyroxine was administered to infant rats within the first 3 days of postnatal life; controls receiving 0.01N NaOH were from the same litter. Thyroxine accelerated the maturation of the pituitary-adrenal response to elec tric shock. The "startle response" ap peared earlier in the experimental ani mals, as did the development and re sponse of the electroencephalogram to novel stimuli. The thyroxine-treated rats, when 16 to 18 days old, acquired a conditioned-avoidance response faster than did controls.


Prevention of induced atherosclerosis by peroxidase. Hepatocatalase peroxidase, an active peroxidase-oxidase subunit isolated from beef-liver catalase, prevents cholesterol deposition and aortic atherosclerosis in cholesterol-fed rabbits and has no apparent toxicity or undesirable de effects. No allergic or immunological reactions have been observed. The participation of this enzymatic subunit in homeostatic control mechanisms and its potential pharmacological value in the control of human atherosclerosis are suggested.


Retinal telangiectasia associated with hypogammaglobulinemia.


Prevention of protein denaturation during exposure to sterilization temperatures. Firefly luciferase exposed to a temperature of 135 degrees C for 36 hours re tained up to 40 percent of its original activity. Prerequisites for heat stability were the use of a molecular sieve (Seph adex G-25 or Biogel P-300) and a high vacuum (5 x 10(-4) mm-Hg). These studies present a possible solution to the problem of sterilization for exobiologi cal experiments.


Retinal function studies in hysterical amblyopia. A unique abnormality of dark adaptation.


Oxidative phosphorylation in experimental bilirubin encephalopathy. Mitochondria from the whole brain or cerebellum of newborn guinea pigs with experimental bilirubin encephalopathy failed to exhibit uncoupling of oxidative phosphorylation. The pigment concentrations required to initiate uncoupling in vitro are much higher than those found in the brain of neurotoxic animals.


Pleoptics versus occlusion of the sound eye in the management of strabismic amblyopia with eccentric fixation.


Experimental retinal detachment: response to photocoagulation.


Necrogranulomatous keratitis associated with Wegener's granulomatosis and rheumatoid arthritis.


Retinal vascular lesions treated by photocoagulation.


Oculodermal melanocytosis and retinitis pigmentosa.


Massive bilateral choroidal detachment occurring in an aphakic patient six years and nine months postoperatively.


Sympathetic uveitis and phacoanaphylaxis.


Visual field changes produced by artificially elevated intraocular pressure.


Ultrasonographic discovery of cyst formation in metastatic neuroblastoma.


Horner's syndrome with geniculate zoster occurring in association with trigeminal herpes in which the ophthalmic division was spared.


A method of corneal suture removal.

A method of corneal suture removal.


Lipid anomalies in cases of xanthelasma.


Correction of excessive width of the inner canthus.


Congenital absence of external rectus muscle.


Regeneration of the mammalian liver. V. Mitotic division in cytologically differentiated liver cells.


Chronic passive congestion of the liver in man. Electron microscopic study of cell atrophy and intralobular fibrosis.


Hyperacute allergic encephalomyelitis. Lymphatic system as site of adjuvant effect of pertussis vaccine.


An electron microscopic study of leukocyte emigration and vascular permeability in tuberculin sensitivity.


Pathogenesis of jejunal mucosal alterations: synechia formation.


Bacterial infection of aortic aneurysms. A clinicopathologic study.


Ultrasonic flow detection. A useful technic in the evaluation of peripheral vascular disease.


Definitive surgical therapy for perforated peptic ulcer. A review of fifty-two consecutive cases.


Treatment of duodenal ulcer in a small metropolitan community hospital.


Chronic relapsing pancreatitis.

Chronic relapsing pancreatitis.


The external carotid as a brain collateral.


Dynamics of occlusion in vascular prostheses.


Malignant melanoma. Review of sixty-six cases and survey of the literature.


Metastatic hypernephroma of the thyroid gland.


Carcinoma of the thyroid after x-ray therapy to the neck. Report of a patient treated after thirty-two years.


Use of transhepatic intubation in biliary stricture repair.


Epithelial elements in a malignant neurogenic tumor of the tibial nerve.


Small bowel obstruction due to a Birnberg bow.


Obstruction of the pylorus by gallstones.


Active splenic granuloma as a source of recurrent brucellosis. Successful surgical treatment.


Gardner's syndrome and periampullary malignancy.


Dysphagia lusoria secondary to complete vascular ring.


Simple primary closure for sacrococcygeal pilonidal disease.


Colon bypass. A technical note.

Colon bypass. A technical note.


A new type of bowel forceps.

A new type of bowel forceps.


Instruments for open heart surgery.

Instruments for open heart surgery.


Observations concerning 487 patients returned to active military service after treament for pulmonary tuberculosis: progress report.


Mass ambulatory chemotherapy in the treatment of tuberculosis in a predominantly urban community.


Active pulmonary tuberculosis with negative tuberculin skin reactions.


Tuberculous peritonitis. A review of 100 cases.


Systems analysis in tuberculosis control: a model.


Droplet expulsion from the respiratory tract.


Retention of liquid aerosols in the lung.


A technique for evaluation of gas mixing in the lung: studies in cigarette smokers and nonsmokers.


A hospital outbreak of Klebsiella pneumonia from inhalation therapy with contaminated aerosol solutions.


Studies of human leukocyte culture as an in vitro test of delayed hypersensitivity.


Aberrant aorta presenting as a superior mediastinal tumor.


Reversion of recently acquired tuberculin reactivity during isoniazid prophylaxis.


Hamycin: chemotherapeutic studies in systemic mycoses of man.


Occurrence of Mycoplasma among patients with chronic chest disease.


Comparative spirometry measurements using a bellows-type and a water-sealed spirometer.


Recovery of culturable tobacco mosaic virus from sputum and thoracentesis fluids obtained from cigarette smokers with a history of pulmonary disease.


Two possibilities of further reduction in mortality from tuberculosis.


Reactivations in active tuberculosis.

Reactivations in active tuberculosis.


Determination of glutamic oxalacetic transaminase activity by coupling of oxalacetate with diazonium salts.


Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays.


Determination of calcium and magnesium in serum, urine, diet, and stool by atomic absorption spectrophotometry.


Determination of unconjugated and total N-acetyl-p-aminophenol (NAPA) in urine and serum.


Determination of sodium in urine by specific ion electrode.


Automated method for the determination of serum creatine kinase activity.


Estimation of the antitrypsin activity of serum.


An in vivo study of the axial rotation of the human thoracolumbar spine.


Straight nails in tibial fractures. Technique and report of thirty cases.


Experimental hemarthrosis. The response of canine knees to injections of autologous blood.


Ulnar deviation of the fingers. The role of joint structure and function.


Congenital angular deformity of the digits. Delta phalanx.


Fractures and dislocations of the spine complicating ankylosing spondylitis. A report of six cases.


Oblique trochanteric osteotomy.

Oblique trochanteric osteotomy.


Synovial cysts (ganglia) of bone. Report of two cases.


Osteomyelitis of the odontoid process. A case report.


Slow arterial leak consequent to unrecognized arterial laceration. Report of five cases.


Non-osteogenic fibroma occurring in the ilium. Report of a case.


Congenital metatarsus varus.

Congenital metatarsus varus.


Reconstruction of the hip in rheumatoid arthritis.


Human placental lactogen: studies of its acute metabolic effects and disposition in normal man. The acute metabolic effects and disposition of human placental lactogen (HPL) have been studied in 15 men and 8 women during continuous intravenous infusions. The mean plasma half-life, metabolic pool size, and turnover rate of HPL are comparable to the values previously reported for human growth hormone (HGH). From the data presented, we calculate that the placenta secretes approximately 290 mg HPL daily at term. After 12-hour infusions of HPL in physiologic amounts, impairment of glucose tolerance despite increased plasma insulin responses to glucose was observed in 7 of 8 subjects tested. However, HPL, unlike HGH, did not produce significant changes in blood glucose, plasma insulin, or plasma free fatty acid concentrations in fasting subjects before glucose administration or in carbohydrate tolerance or plasma insulin responses to glucose during 5-hour infusions. These findings are compatible with the thesis that HPL is a physiologic antagonist to insulin during pregnancy.


Measurement of gastrointestinal protein loss using ceruloplasmin labeled with copper. Ceruloplasmin labeled with (67)copper and administered intravenously to dogs, control human subjects, and patients with excessive gastrointestinal loss was shown to fulfill the requirements for a label for quantification of gastrointestinal protein loss. The radiocopper moiety was poorly absorbed from the gastrointestinal tract, not actively secreted into the intestinal tract, and did not alter significantly the metabolism of ceruloplasmin. Approximately 70% of the body pool of ceruloplasmin in both dog and man was within the intravascular space. In control human subjects the mean ceruloplasmin concentration was 30 mg per 100 ml with total circulating and total body ceruloplasmin pools of 15.5 and 22 mg per kg, respectively. In patients with excessive gastrointestinal protein loss secondary to intestinal lymphangiectasia, the serum ceruloplasmin concentration was reduced to 16 mg per 100 ml with a comparable reduction in the total circulating and total body ceruloplasmin pools to 8.8 and 12 mg per kg. The survival half-time of ceruloplasmin was 6.1 days in normal human subjects and 4.5 days in normal dogs. From 1.0 to 1.9% of the intravascular pool of ceruloplasmin was lost into the gastrointestinal tract of the dog per day, representing less than 11% of the over-all metabolism of this protein. In control human subjects from 1.9 to 3.9% of the intravascular pool was lost into the gastrointestinal tract each day, representing a maximum of from 11 to 22% of the over-all metabolism of this molecule. In contrast, patients with intestinal lymphangiectasia had a markedly shortened ceruloplasmin survival of 3.1 days, with from 15 to 40% of the intravascular pool of ceruloplasmin cleared into the gastrointestinal tract daily. This represented 76% of the over-all metabolism of this protein. Thus, although bulk loss of serum proteins into the gastrointestinal tract does not normally appear to be a significant factor in protein metabolism in normal dogs and men, such loss is a major factor in the pathogenesis of the hypoceruloplasminemia noted in patients with intestinal lymphangiectasia.


Increased plasma arginine vasopressin in clinical adrenocortical insufficeincy and its inhibition by glucosteroids. Trichloroacetic acid extracts of plasma were fractionated on a CG-50 resin column and the 50% acetic acid eluents chromatographed on silicic acid-impregnated glass paper in butanol-acetic acid-water. The specific arginine vasopressin (AVP) zone was eluted and assayed for antidiuretic activity in the diuretic rat. Thioglycolate inactivation was used to confirm AVP activity. Recovery of as little as 4 muU AVP per ml plasma ranged between 80 and 90%. In normal subjects after an overnight fast, plasma AVP ranged between 2.5 and 10.0 muU per ml. AVP secretion was inhibited by hemodilution and stimulated with nicotine and hypertonic saline. Plasma AVP was absent in patients with diabetes insipidus even after neurohypophyseal stimulation. Plasma AVP was abnormally elevated during mild dehydration and remained above the normal range despite hemodilution in patients with untreated adrenocortical insufficiency demonstrating a delayed water diuresis. Glucosteroid therapy lowered plasma AVP to normal in dehydrated patients. A normal diuretic response to hydration was accompanied by a fall in plasma AVP to zero in steroid-treated patients. These findings suggest that hypersecretion of AVP may play an important role in the abnormal water metabolism of adrenocortical insufficiency and that the glucosteroids promote normal water diuresis by inhibiting the secretion of AVP from the neurohypophysis.


Blood ferrokinetics in normal man.

Blood ferrokinetics in normal man. The clearance of radioiron from plasma and its appearance in circulating erythrocytes in normal subjects are studied. The importance of correcting for plasma iron fluctuations and for mean body hematocrit is illustrated. The data are analyzed by probability theory to determine relationships between intravascular and extravascular iron. Two refluxes are described, one of about 7 particles of every 100 leaving the plasma, and the second of about 23. The return times of these are about 5 hours and 8 days, respectively.


Lung tissue resistance in diffuse interstitial pulmonary fibrosis. 1) Measured during spontaneous breathing in ten patients with diffuse interstitial lung disease, total pulmonary resistance averaged 3.53 +/- 1.56 cm H(2)O per L per second; airway resistance, 1.63 +/- 0.79 cm H(2)O per L per second; and lung tissue resistance, 1.90 +/- 0.95 cm H(2)O per L per second (range, 0.89 to 3.96). The lung tissue resistance was on an average about four times higher in patients with lung fibrosis than in ten healthy persons of the same age. No significant difference in airway resistance was found between healthy subjects and patients.2) In three patients the lung tissue resistance was measured during spontaneous breathing and during panting. Much higher values were found during spontaneous breathing.3) In patients with lung fibrosis and also in healthy subjects, there seems to have been an inverse correlation between the vital capacity, or the compliance, on the one hand, and the lung tissue resistance on the other. Nevertheless, in patients with lung fibrosis the lung tissue resistance was more increased than could be attributed to the loss of normally compliant lung tissue only.4) No correlation was found between the lung tissue resistance and severity of impairment of pulmonary gas exchange; especially no relationship appeared to exist between the lung tissue resistance and the alveolar-end capillary PO(2) gradient during hypoxia. This result indicates that the pathological alterations producing a measurable end gradient in hypoxia may be independent of the augmentation of the fibrous framework responsible for the stiffening of the lung.


Intestinal transport of cystine and cysteine in man: evidence for separate mechanisms. Cystine and cysteine are transported by energy-dependent, mediated processes in human gut. When either of these amino acids is transported, only cysteine is recovered intracellularly, indicating that cystine is reduced to cysteine after achieving an intracellular location. In contrast to results with cystine, cysteine uptake is not defective in gut from cystinuric patients, nor do lysine and arginine compete with cysteine for transport. It is, therefore, concluded that cystine and cysteine are transported by different mechanisms, and that only the cystine transport mechanism is defective in cystinuria.


Studies on the absorptive defect for triglyceride in abetalipoproteinemia. The nature of the gastrointestinal absorptive defect for triglyceride in three subjects with abetalipoproteinemia has been investigated by studying peroral biopsies of the gastrointestinal mucosa. The following conclusions were reached.1) In confirmation of other studies, the abnormal vacuoles within the duodenal absorptive cells of these individuals were lipophilic.2) On chemical analysis there was significantly more mucosal lipid than found in normal fasting specimens, and almost the entire increase was due to triglyceride.3) This excess mucosal lipid was reduced by a low fat diet, but even after 34 days on such a diet there was still an excess of lipophilic material near the villus tip and increased quantities of total lipid and triglyceride when compared with material from normal subjects similarly treated.4) Although there are demonstrable qualitative changes in mucosal and plasma lipids after an acute fat load, they are not quantitatively as great as in normal individuals. Fat balance studies and the qualitative changes in plasma and tissue lipids that do occur after more extended periods on different types of dietary fat do indicate that a considerable percentage of the dietary fat is assimilated. The route by which it is absorbed remains to be clarified.


The mechanism of suppression of proximal tubular reabsorption by saline infusions. The mechanism by which expansion of extracellular fluid volume with isotonic saline suppresses reabsorption in the proximal tubule was studied in rats by examining the relations among glomerular filtration rate (GFR), absolute and fractional reabsorption of filtrate, intrinsic reabsorptive capacity (rate of reabsorption per unit tubular volume), transit time, and tubular volume. Saline infusions reduced the per cent of the glomerular filtrate reabsorbed in the proximal tubule from 50% during antidiuresis to 25% during saline diuresis. The suppression of proximal reabsorption was the result of two factors: 1) a 30% reduction of intrinsic reabsorptive capacity, and 2) a 26% reduction of tubular volume per unit GFR.GFR invariably rose during saline diuresis. However, prevention of the rise in GFR by aortic clamping had no effect on either the inhibition of intrinsic reabsorptive capacity or the reduction in tubular volume per unit GFR produced by saline infusions. Expansion of extracellular fluid volume with isotonic saline, therefore, depressed intrinsic reabsorptive capacity and tubular volume per unit GFR by some mechanism completely independent of GFR. The effects of furosemide administration were contrasted with those of saline infusions. Furosemide inhibited intrinsic reabsorptive capacity by 40% but had no significant effect on proximal fractional reabsorption. The failure to suppress fractional reabsorption was the consequence of a disproportionate rise in tubular volume (relative to GFR) that was sufficient to completely overcome the inhibition of intrinsic reabsorptive capacity. Inhibition of intrinsic reabsorptive capacity alone, therefore, will not result in a net suppression of reabsorption of filtrate in the proximal tubule. We concluded that, although intrinsic reabsorptive capacity was inhibited during saline diuresis, the critical factor responsible for translating this inhibition into effective net suppression of proximal reabsorption was the observed reduction in tubular volume per unit GFR.


Thyrocalcitonin and the response to parathyroid hormone. 1) In the absence of the thyroid gland, the infusion of parathyroid hormone leads to a prompt rise in plasma calcium and to prompt increase in the rate of excretion of calcium in the urine.2) In the presence of the thyroid gland, the parathyroid hormone-induced rise in plasma calcium is less marked; the rate of urinary calcium excretion falls initially and rises only after 20 to 30 hours of continuous parathyroid hormone infusion.3) The infusion of exogenous thyrocalcitonin along with the parathyroid hormone into a thyroparathyroidectomized animal leads to a pattern of response similar to that seen in the animal with an intact thyroid gland.4) Thyrocalcitonin has little apparent effect upon the immediate changes in renal function induced by parathyroid hormone.5) We conclude that bone is a major site of action of thyrocalcitonin and that it probably inhibits bone resorption.


A receptor mechanism for the inhibition of insulin release by epinephrine in man. Normal adult men and women have been infused with epinephrine, 6 mug per minute, during lipolytic blockade with nicotinic acid, beta-adrenergic blockade with propranolol and Butoxamine, and alpha-adrenergic blockade with phentolamine. Epinephrine infusion was associated with low serum levels of immunoreactive insulin (IRI) except when phentolamine was given simultaneously. These findings are compatible with an alpha receptor mechanism for the epinephrine inhibition of insulin release. Phentolamine had no blocking effects on the tachycardia and widened pulse pressure or lipolytic stimulation by epinephrine, whereas both propranolol and Butoxamine blocked lipolysis, tachycardia, and widened pulse pressure. These findings are consistent with an alpha receptor blocking action for phentolamine and beta receptor blocking action for propranolol and Butoxamine. Inhibition of lipolysis by nicotinic acid did not alter IRI or glucose responses to epinephrine. It is concluded that the lipolytic effect of epinephrine is unrelated to its effects on IRI release. Lipolytic blockade by nicotinic acid also did not change IRI or glucose in fasting subjects or their responses to a glucose infusion, 300 mg per minute. These observations appear to conflict with the Randle hypothesis (the glucose-fatty acid cycle) and raise some doubt as to whether plasma FFA concentrations are direct determinants of glucose or IRI concentrations in normal man.


The concentration dependence of active potassium transport in the human red blood cell. The relation between the active potassium influx in the human red blood cell and the extracellular potassium concentration does not appear to be consistent with the Michaelis-Menten model, but is adequately described by a model in which two potassium ions are required simultaneously at some site or sites in the transport mechanism before transport occurs. The same type of relation appears to exist between that portion of the sodium outflux that requires the presence of extracellular potassium and the extracellular potassium concentration. Rubidium, cesium, and lithium, which are apparently transported by the same system that transports potassium, stimulate the potassium influx when both potassium and the second ion are present at low concentrations, as is predicted by the two-site model.


Light chain distribution in immune deposits on glomeruli of kidneys in human renal disease. The gammaG-immunoglobulin (IgG) deposited on glomeruli of 32 percutaneous renal biopsies from 30 patients with various forms of renal disease was examined by fluorescent techniques to determine its light chain composition. Serum kappa: lambda light chain ratios were determined on 17 serum samples from 16 of the 30 patients. Glomerular IgG staining with only antikappa antiserum, only antilambda antiserum, and with both antisera was demonstrated. No correlation of serum kappa: lambda light chain ratios with the type or types of light chains demonstrable on the glomeruli was observed. We concluded that the IgG deposited on glomeruli of patients with various forms of renal disease is not a nonspecific sample of the circulating immunoglobulin pool but may well reflect more specific selection, as in the deposition of specific antibody formed against exogenous or endogenous antigens during the development of the renal lesion.


The immunologic character of acquired inhibitors of antihemophilic globulin (factor 8) and the kinetics of their interaction with factor 8. Investigations were undertaken of the chemical nature and kinetics of interaction of three acquired inhibitors of Factor VIII. The inhibition was stoichiometric, one molecule of inhibitor (or one site on a molecule) being required to inactivate one molecule of Factor VIII. All three inhibitors were found to be monotypic antibodies of class IgG, Type K (gamma(2) kappa(2)). This appears to be the second syndrome due to the production of monotypic antibody, and the first instance involving IgG immunoglobulins.


Glucose titration studies in patients with chronic progressive renal disease. Glucose titration studies were performed on 17 patients with either chronic pyelonephritis or chronic glomerulonephritis. Glomerular filtration rates for the group ranged from 4.3 to 58.1 ml per minute. In none of the patients in whom the glomerular filtration rate was over 15 ml per minute was there appreciable splay, and the mean titration curve for these patients resembled that obtained by Smith and associates in normal man (1). In half of this group of eight patients, GFR ranged from 16.6 to 22.7 ml per minute; in the other half values ranged from 42.3 to 58.1 ml per minute. Yet, the mean titration curves were identical for the two groups. In addition, no difference was observed in the titration curves for patients with pyelonephritis and those with glomerulonephritis. In patients with GFR values below 15 ml per minute, increased splay was observed, and below a GFR of 10 ml per minute, the splay was very marked. Both the absence of exaggerated splay in patients with reduction of glomerular filtration rate by as much as 85%, and the emergence of exaggerated splay in patients with more marked reduction of GFR, require explanation. Theoretical considerations are presented in the text.


On the mechanism of the splay in the glucose titration curve in advanced experimental renal disease in the rat. Glucose titration studies were performed in rats with unilateral chronic pyelonephritis before and after removal of the contralateral control kidneys. Identical studies were performed in animals with unilateral partial renal infarction in which the experimental kidneys had a marked reduction in nephron population but no anatomic deformation in the surviving nephrons. In the initial studies, both groups of animals were free of clinical and chemical abnormalities of uremia. In the follow-up studies uremic abnormalities were present. Minimal splay was observed in the titration curves in the initial studies; marked splay was present in the group data from the same kidneys in the subsequent studies. Thus a marked reduction in the nephron population was associated with the evolution of splay in both groups of animals. In association with the increase in splay, the mean values for maximal glucose transport increased; thus a defect in glucose transport can be excluded as the basis of the splay. Glomerular filtration rate increased proportionately more than the maximal transport of glucose; hence the ratios of glomerular filtration rate to maximal glucose transport increased consistently. The possibility of asymmetric hypertrophy of glomerular and tubular functions among the nephron population imposed by scar tissue or other anatomic deformities was considered, but the results in the animals with partially infarcted kidneys militate against this explanation. The splay also could reflect an asymmetric alteration in the distribution of glomerulotubular balance among the residual units initiated by functional adaptations. Finally, the splay could relate to an alteration in the kinetics of glucose transport without any change in the level of functional homogeneity. The possible nature of these has been considered in the text.


Concomitant alterations of sodium flux and membrane phospholipid metabolism in red blood cells: studies in hereditary spherocytosis. The role of membrane phosphatides in transport processes has been investigated in red cells from splenectomized patients with hereditary spherocytosis (HS). Incorporation of inorganic (32)phosphate into the membrane phosphatides of HS red cells was approximately twice normal, coinciding with the nearly twofold increment in flux of sodium ions in the cells.A consistent, inordinate increase in specific activity of a chromatographic fraction containing phosphatidylserine provided the bulk of the over-all increase in labeling of HS red cell phosphatides. The specific activity of phosphatidic acid was increased but not consistently. Radioactivity of the "acidic phosphatides" (phosphatidylserine and phosphatidic acid fractions) decreased, in general, when the sodium flux was low, i.e., when the cells were suspended in media of low sodium content. When the cation flux was elevated (hypotonic media), there was a marked (ca. 35%) increase in the labeling of phosphatidylserine fractions. Normal red cells whose permeability to cations was increased by exposure to 0.5 N butanol also exhibited increased labeling of acidic phosphatides. Considerations of the stoichiometry of cation transport and phosphatide labeling make it unlikely that phospholipids act directly as carrier molecules for cations in red cell membranes. On the other hand, the involvement of these lipid substances in cation movements is substantiated by correlating several different states of sodium flux with the labeling of the phosphatidic acid and phosphatidylserine fractions.


Atrial fibrillation in the intact unanesthetized dog: hemodynamic effects during rest, exercise, and beta-adrenergic blockade. The effects of atrial fibrillation were studied in 12 healthy unanesthetized dogs, 9 to 49 days after surgical implantation of transducers for measurement of aortic flow and left ventricular diameter. Atrial fibrillation and pacing at comparable ventricular rates were induced by electrical stimulation of the right atrial appendage, and their effects were compared with observations made during sinus rhythm in each dog. At rest, cardiac output and mean arterial pressure were not significantly different during sinus rhythm, atrial fibrillation, and atrial pacing. After beta-adrenergic blockade with propranolol, cardiac output during fibrillation was significantly less than that during pacing at comparable ventricular rates. Arterial pressure was not detectably altered. During moderately severe treadmill exercise by six dogs, cardiac output fell significantly upon induction of fibrillation. After pentobarbital anesthesia fibrillation caused decrements in cardiac output and arterial pressure that were accentuated after thoracotomy.These observations suggest the existence of compensatory mechanisms that maintain an essentially constant cardiac output when atrial fibrillation is induced in healthy unanesthetized dogs at rest. These mechanisms appear to fail during moderately severe exercise, beta-adrenergic blockade, and pentobarbital anesthesia.


Regulation of renal citrate metabolism by bicarbonate ion and pH: observations in tissue slices and mitochondria. The effect of acid-base balance on the oxidation and utilization of citrate and other organic acids has been studied in tissue slices and isolated kidney mitochondria. The results show that: 1) With bicarbonate-buffered media, citrate oxidation and utilization are inhibited in slices of renal cortex and in kidney mitochondria when [HCO(3) (-)] and pH are increased within the physiologic range (pH 7.0 to 7.8; 10 to 60 mumoles HCO(3) (-) per ml). When phosphate or Tris buffers are used, no comparable effect on citrate oxidation occurs when pH is varied. 2) This effect is not demonstrable in heart or liver slices when a physiologic buffer is used. 3) alpha-Ketoglutarate utilization is inhibited in slices of renal cortex under similar conditions. Pyruvate and L-malate utilization are not inhibited in slices or mitochondria. 4) Citrate content in slices of renal cortex incubated with a high [HCO(3) (-)] is considerably greater than the concentration found with a low [HCO(3) (-)] in the medium. This effect is not duplicated by pH change in a nonbicarbonate buffer system. In mitochondria citrate content is also increased markedly at high bicarbonate concentrations. 5) The kinetic characteristics of the inhibition of citrate oxidation are those of a competitive type of inhibition. 6) When pH was varied with a constant [HCO(3) (-)] in the media, citrate oxidation was inhibited by increasing pH in slices of renal cortex but not in mitochondria. On the other hand, when [HCO(3) (-)] was increased without change in pH, no decrease in citrate oxidation occurred in slices, but a marked inhibitory effect was found when mitochondria were used. From a comparison of these results with those previously obtained in intact animal experiments, we conclude that the inhibition of citrate oxidation caused by increasing pH and [HCO(3) (-)] in slices of renal cortex and kidney mitochondria is an in vitro representation of the inhibition of citrate reabsorption in the nephron that occurs in metabolic alkalosis. Thus, citrate clearance increases in metabolic alkalosis because of inhibition of oxidation of reabsorbed citrate within cells of the renal tubules. This inhibition is the result of an inhibitory effect of bicarbonate ion on citrate oxidation in mitochondria.


Effect of diet upon intestinal disaccharidases and disaccharide absorption. The administration of a carbohydrate-containing diet for 24 hours to rats previously fasted for 3 days led to a twofold increase in total intestinal sucrase and sucrase specific activity. The specific activity of maltase was similarly increased, but lactase activity was unaffected. The sucrose-containing diet led to a greater increase in sucrase than maltase activity, whereas the converse was true of the maltose-containing diet. A carbohydrate-free isocaloric diet led to a slight increase in the total intestinal sucrase, but sucrase specific activity was unchanged. Assay of sucrase activity of mixed homogenates from casein-fed and sucrose-fed rats or fasted and sucrose-fed animals yielded activities that were additive. The Michaelis constant (Km) of the enzyme hydrolyzing sucrose was similar in the fasted, casein-fed, and sucrose-fed rats. The maximal velocity (Vmax) was twice greater in sucrose-fed as compared to casein-fed or fasted rats, suggesting an increased quantity of enzyme subsequent to sucrose feeding. Adrenalectomized rats maintained on 1.0% salt intake had sucrase and maltase levels comparable to those of controls. Steroid administration did not significantly increase their activities. The response to sucrose feeding was similar in both control and adrenalectomized rats, indicative of the absence of steroidal control on sucrase and maltase activity in the adult animal. Studies using intestinal ring preparations indicated that sucrose hydrolysis by the intact cells proceeded more rapidly when animals were fed sucrose. Additional corroboration of the physiologic significance of the increased enzyme levels in homogenates was afforded by intestinal perfusion studies. Sucrose hydrolysis increased twofold and fructose absorption fourfold in animals fed sucrose when compared to either fasted or casein-fed rats.


Tissue lipoprotein lipase in normal individuals and in individuals with exogenous hypertriglyceridemia and the relationship of this enzyme to assimilation of fat. Lipoprotein lipase activity (LLA) was measured in the adipose tissue of six healthy subjects and five members of a family in whom the trait for familial exogenous hypertriglyceridemia was segregating. The lipase activity measured was characteristic of lipoprotein lipase: increased by feeding, dependent on the presence of serum, and inhibited by sodium chloride and protamine sulfate. When compared with lipase activity in healthy individuals, LLA was grossly deficient in two siblings with postabsorptive chylomicronemia and was intermediate in both parents and one sibling, who had normal postabsorptive triglycerides. These findings are compatible with autosomal recessive inheritance. The hormone-sensitive lipolytic enzyme responsible for mobilization of free fatty acids from adipose storage was normal in the hyperlipemic subjects. After a 104-g fat meal, the serum triglyceride increased more in subjects heterozygotic for LLA deficiency than in the healthy subjects, and there was a relatively greater increase in chylomicrons and very low density lipoproteins in the affected individuals. These observations demonstrate the physiologic importance of lipoprotein lipase in removal of these lipoprotein groups and further clarify the differences between endogenous and exogenous hypertriglyceridemia.


Evidence that an acute increase in glomerular filtration has little effect on sodium excretion in the dog unless extracellular volume is expanded. The concept that acute increases in glomerular filtration rate (GFR) will cause large concomitant increases in sodium excretion has been re-examined. In previous work, GFR was elevated by volume expansion, usually with saline infusions. Recent evidence shows that tubular reabsorption is depressed during saline loading; hence, the independent effect of increased GFR on sodium excretion cannot be assessed.TO DETERMINE THE EFFECT OF ACUTE INCREASES IN GFR PER SE ON SODIUM EXCRETION, WE RAISED GFR BY FOUR TECHNIQUES NOT INVOLVING VOLUME EXPANSION: protein feeding, dopamine infusion, intravenous dexamethasone, and cross-circulation. GFR increased acutely by 5 to 85% in these experiments. In 12 of 24 experiments, GFR increased by more than 30%. In all but one experiment, sodium excretion increased by less than 75 muEq per minute. Data from experiments using each of the four techniques were comparable. The results were the same whether mineralocorticoid activity was high or low. In contrast, during saline loading, sodium excretion increased more than 800 muEq per minute with equal or lesser changes in GFR. These results demonstrate that acute increases in GFR per se have little effect on sodium excretion. We suggest that, due to constant fractional sodium reabsorption in the proximal tubule (glomerulotubular balance) and increased distal reabsorption, virtually all of the increase in filtered sodium is reabsorbed when GFR increases. Depression of tubular reabsorption is required for natriuresis.


Radioimmunoassay for luteinizing hormone in human plasma or serum: physiological studies. It is not practical to quantitate gonadotropin in the blood of normal men and women by utilizing bioassays. We have developed a method for sensitive, precise, and specific radioimmunoassay of luteinizing hormone (LH) in human serum or plasma. Antisera were developed against human chorionic gonadotropin, and one of these was selected for extensive cross-reaction with human LH. Highly purified LH was radioiodinated by the method of Greenwood, Hunter, and Glover. Separation of antibody-bound from free LH-(131)I was accomplished by a double antibody technique. Dose-response curves for the purifed LH, an impure urinary LH preparation, pituitary powder, and LH in plasma were all identical. Immunoassay and bioassay of impure urinary and pituitary gonadotropin preparations in terms of a common standard resulted in an index of discrimination of close to unity. LH levels in plasma from 32 adult men and 30 women outside the midcycle ranged from 0.6 to 3.2 mmug per ml (1 mmug of our laboratory LH standard is equivalent to 8 mU of the Second International Reference Preparation of Human Menopausal Gonadotropin). Levels were remarkably constant in men from day to day and in women except at midcycle, when a sharp peak occurred lasting less than 24 hours. In all women studied who had a midcycle LH peak, mean plasma LH levels during the follicular phase of the menstrual cycle were higher than mean values obtained during the luteal phase. Prepubertal children had detectable plasma LH, and mean values were only slightly less than in adults. Plasma from castrate men or women or postmenopausal women contained 4.5 to 10.5 mmug per ml. Clomiphene treatment of four men resulted in a doubling of plasma LH in 5 days.


Complement associated peptidase activity of guinea pig serum. I. Role of complement components.


Complement associated peptidase activity of guinea pig serum. II. Role of a low molecular weight enhancing factor.


Studies on human peripheral blood lymphocytes in vitro. 3. Fine structural features of lymphocyte transformation by pokeweed mitogen.


The effect of treatment of acidosis on calcium balance in patients with chronic azotemic renal disease. Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present. Only small quantities of calcium were excreted in the urine, but fecal calcium excretion equaled or exceeded dietary intake. Complete and continuous correction of acidosis by NaHCO(3) therapy reduced both urinary and fecal calcium excretion and produced a daily calcium balance indistinguishable from zero. Apparent acid retention was found throughout the studies during acidosis, despite no further reduction of the serum bicarbonate concentration. The negative calcium balances that accompanied acid retention support the suggestion that slow titration of alkaline bone salts provides an additional buffer reservoir in chronic metabolic acidosis. The treatment of metabolic acidosis prevented further calcium losses but did not induce net calcium retention. It is suggested that the normal homeostatic responses of the body to the alterations in ionized calcium and calcium distribution produced by raising the serum bicarbonate might paradoxically retard the repair of skeletal calcium deficits.


Immunologic relationship between blood group substances and a fucose-containing glycolipid of human adenocarcinoma.


Localization of anti-brain radioantibodies in rat brain.


Hereditary deficiency of the second component of complement (C'2) in man: further observations on a second kindred.


Radioiodination of antibodies and adsorbed to insoluble antigens.


The removal of acoustic neurinomas.

The removal of acoustic neurinomas.


Quantitative hemadsorption, a new assay technique. II. Assay of neutralizing antibodies to hemadsorbing viruses.


Reversal of post-thymectomy wasting disease in mice by multiple thymus grafts.


Epidermoid (mixed) tumors of the central nervous system.


Lumbar intervertebral disc disease in Africans.


Effect of experimental water restriction on brain water.


Wound infections complicating neurosurgical procedures.


Electromyographic analysis of the lumbar musculature in patients operated on for lumbar rhizopathy.


Experimental cerebral infarction: modification by treatment with hemodiluting, hemoconcentrating, and dehydrating agents.


Primary malignant leptomeningeal melanoma in association with giant hairy nevi.


Acoustic tumors.

Acoustic tumors.


Treatment of basal skull fractures with and without cerebrospinal fluid fistulae.


Glial origin of monstrocellular tumor. Case report of prolonged survival.


Fatal hemorrhage into a medulloblastoma. Case report.


Bilateral spontaneous carotid-cavernous fistulae in Ehlers-Danlos syndrome. Case report.


Retrobulbar orbital myxoma and its detection by ultrasonography. Case report.


The use of adhesive and lyophilized dura in the treatment of cerebrospinal rhinorrhea. Technical note.


A technique for recording single neuron potentials in the human spinal cord. Technical note.


Compendium on shortness of stature.

Compendium on shortness of stature.


Permanent intracochlear electrodes in cats, tissue tolerance and cochlear microphonics.


Secondary phase nystagmus: the caloric test.


Surgical obliteration of the maxillary sinus. A clinical and experimental study.


Hyporhinolalia associated with Eustachian tube dysfunction.


Hodgkin's disease of the nasopharynx. Report of a case.


Chemodectomas of the glomus jugulare tumors.


A method of examination of the larynx through a suspension laryngoscope, using a bronchoscopic telescope.


Adrenalectomy for metastatic mammary carcinoma.


Electronystagmography in the diagnosis of vertigo. I.


A pollen survey in Canberra.

A pollen survey in Canberra.


Aspects of the management of acute pancreatitis.


Sampling for serial blood volume estimations in children.


A review of cancer of the cervix in New South Wales. I.


A diencephalic syndrome of early infancy.


A true circle conversion for the C.I.G. "midget mark 1" anaesthetic machine.


Bat ears.

Bat ears.


Allergic broncho-pulmonary aspergillosis.


Dermoid cysts of the brow, a technique of excision.


Ocular complications of midfacial fractures.


Treatment of tracheal stenosis.

Treatment of tracheal stenosis.


The pharyngeal flap as a speech mechanism.


Blood volume determinations in cleft lip-palate infant surgery.


Primary restoration of thumb opposition with median nerve decompression.


Induced resolution of cavernous hemangiomas following prednisolone therapy.


A European trip sponsored by the Foundation of the American Society of Plastic and Reconstructive Surgery.


Loss of nerve function in the hand caused by ganglions.


Random reflections on rhinoplasty.

Random reflections on rhinoplasty.


Results of cleft palate operations.

Results of cleft palate operations.


Tear gas gun injury of the hand.

Tear gas gun injury of the hand.


Management of hemophilia in plastic surgery.


Some thoughts on resident and post-residency training.


Carcinoma-in-situ of the urinary bladder--histological and cytological observations.


Post-nephrectomy arteriovenous fistula.

Post-nephrectomy arteriovenous fistula.


Diet in chronic renal failure.

Diet in chronic renal failure.


Surgical problems of renal failure.

Surgical problems of renal failure.


Problems in the management of primary pelvic hydronephrosis.


The value of infusion urography.

The value of infusion urography.


Bladder tumours in rubber workers.

Bladder tumours in rubber workers.


Immunosuppression in relation to organ transplantation.


Operations on the lower end of the ureter and ureteric reflux.


Werner's syndrome ('progeria of the adult').


Ruptured amoebic liver abscess leading to inferior vena cava obstruction.


Mitral incompetence following acute cardiac infarction treated surgically.


Coeliac axis stenosis.

Coeliac axis stenosis.