Calcium movements in resting and stimulated isolated rabbit atria.


Monoamine oxidase inhibiting properties of SU-11,739 in the rat. Comparison with pargyline, tranylcypromine and iproniazid.


Paroxysmal positional giddiness.

Paroxysmal positional giddiness.


Drug-dependence in psychiatric patients.


The effect of disulfiram on catecholamine levels in the brain.


Histological changes in the trachea and bronchi with tracheostomy.


Hodgkin's disease of the pleura: an unusual presentation.


Acute haematogenous osteomyelitis of the os calcis.


Melioidosis.

Melioidosis.


Medical records.

Medical records.


Two different excitatory transmitters acting on a single molluscan neurone.


Melanin, a possible pigment for the photostable electrical responses of the eye.


Mechanism of action of aminothiol radioprotectors.


Mechanism of the insect ear.

Mechanism of the insect ear.


Synthesis of nucleic acids in hair.

Synthesis of nucleic acids in hair.


Respiratory response to carbon dioxide in man.


Demonstration of nerve terminals containing adrenaline by a new histochemical technique.


Origin of eyes and brains.

Origin of eyes and brains.


Oculosympathetic response to circulatory arrest.


Stimulating effect of xylose on the utilization of galactose in some fungi.


Thymectomy and anaphylactic antibody in rats infected with Nippostrongylus brasiliensis.


Synthesis of seleno-amino-acids in cell free extracts of Candida albicans.


Reduction of methaemoglobin in haemoglobin samples using gel filtration for continuous removal of reaction products.


Platelet electrophoretic behaviour in thrombasthenia.


Bioassay of the red chromatophore concentrating hormone of the crayfish.


Multiple specificity of thrombin for synthetic substrates.


1,6-Dibromo-1,6-dideoxy-dulcitol: a new antitumoral agent.


Quantitative determination of conjugated bile acids in serum in acute hepatitis.


Effects of oestrone-17-beta-thiol on the endocrine organs of the castrated female rat.


Effect of histones, other basic proteins and some antibiotics on the transplantability of mouse mammary tumours.


Party game model of biological replication.


Perfusion fluid for the scorpion, Heterometrus fulvipes.


Amino-acid composition of ascitic fluid and blood plasma from mice bearing Ehrlich-Lettre tumour.


Protein synthesis and enzyme response to contractile activity in skeletal muscle.


Palaeo-electron microscopy of mummified tissue.


Reflected light interference microscopy of living and fixed biological surfaces.


Flavianic acid as a hatching agent for Heterodera cruciferae Franklin and other cyst nematodes.


Juvenile sterility in male ticks of Ornithodoros tholozani.


Larval moulting cycle and DNA synthesis in Drosophila hydei salivary glands.


A comparison of cardiac rhythm during halothane and methoxyflurane anaesthesia at normal and elevated levels of PaCO-2.


Increased sensitivity to the muscle-relaxing effect of succinylcholine in irradiated rabbits.


Endotracheal and tracheostomy tubes with self-inflating cuff.


The respiratory effects of pentazocine.

The respiratory effects of pentazocine.


Ergonomics: the state of the art.

Ergonomics: the state of the art.


The assessment of the work place--a prerequisite to the diagnosis of occupational chest disease.


A noise and hearing survey of earth-moving equipment operators.


Are there still local exhaust ventilation problems?


Distribution of arsenic in nonexposed persons (hair, liver, and urine).


Standardization of chemical methods in air sampling.


Environmental and clinical control of lead exposure in a non-ferrous foundry.


The occupational hygiene survey: principles, practice, significance.


Cardiac output after portacaval shunt.

Cardiac output after portacaval shunt.


Surgical problems of the biliary ductal system.


Experimental evaluation of inferior vena cava procedures to prevent pulmonary embolism.


Effects of low molecular weight dextran on peripheral blood flow with controlled cardiac output.


Theoretical considerations, design, and evaluation of a cascade impactor.


Vertebral arterial reconstruction: internal plication and vein patch angioplasty.


Course of posthemorrhagic hypotension after celiac ganglionectomy with and without adrenal denervation.


Experience with the New York State Air Pollution Control Rules--industrial sources.


Hygienic guide series.

Hygienic guide series.


Hygienic guide series. Oxygen difluoride (fluorine monoxide).


Penetrating wounds of the abdomen: analysis of 155 cases with problems in management.


Penetrating heart wounds: analysis of 12 consecutive case individualized without mortality.


Selective conservative management of penetrating abdominal wounds.


Malignant vascular tumors of the lymphedematous extremity.


Studies in burns: IV. The relationship of eschar water content to eschar water transmissivity.


Respiratory gas tensions of thoracic duct lymph: an index of gas exchange in splanchnic tissues.


Femoral hernia in childhood.

Femoral hernia in childhood.


Volvulus of the cecum.

Volvulus of the cecum.


Moderation.

Moderation.


Hemangiomas of the subglottic region, trachea, and mediastinum in infancy and childhood.


Achalasia and esophageal carcinoma.

Achalasia and esophageal carcinoma.


Experimental emphysema.

Experimental emphysema.


Recurrent aneurysm of the abdominal aorta. Insertion of a vascular prosthesis from the distal aortic arch to the femoral arteries.


Closure of an esophagopleural fistula using onlay intercostal pedicle graft.


A culture medium for the production of Mycoplasma gallisepticum antigen.


The support of the lung during and after traumatic and hemorrhagic shock.


Persistent anisotropy in the livers of ducklings with aflatoxin poisoning.


The antiglobulin procedure for the detection of antibodies of avian origin.


Short communications. Enzymic degradation of cytidine 5'-monophosphate N-acetylneuraminic acid.


Sterol biosynthesis in fungi.

Sterol biosynthesis in fungi.


The iodination of super-reactive and essential tyrosine residues in a microbial aminopeptidase.


Polarographic determination of dipicolinic acid in the presence of bacterial spores and vegetative cells.


Co-operative effects in enzyme catalysis: a possible kinetic model based on substrate-induced conformation isomerization.


Regulation of the concentration or activity of pyruvate kinase in yeasts and its relationship to gluconeogenesis.


Biosynthesis of thyroglobulin and sub-units in the rat thyroid gland in vivo.


Purification and physicochemical properties of human placental lactogen.


The use of photolysis of dinitrophenyl-peptides in structural studies on the cell-wall mucopeptide of Corynebacterium poinsettiae.


The equilibrium sedimentation of hyaluronic acid and of two synthetic polymers. 1. The method of equilibrium sedimentation has been investigated as an alternative to osmotic-pressure measurement for determining thermodynamic properties of polymer solutions at relatively high concentrations. 2. The simplifications that must be made in the theoretical treatment are discussed. 3. Measurements have been made on samples of polyethylene glycol, neutralized polymethacrylic acid and hyaluronic acid. With the first and third, values of the ;non-ideality coefficients' have been obtained that agree with those obtained from osmotic measurements on the same materials. 4. Evidence has been obtained of the presence in hyaluronic acid preparations of a fraction that has either a lower degree of thermodynamic non-ideality or a higher density increment than the bulk of the sample. This fraction is not protein.


Further studies on a new pathway of photosynthetic carbon dioxide fixation in sugar-cane and its occurrence in other plant species. 1. The pathway of photosynthesis in sugar-cane, which gives most of the radio-activity fixed during short periods in (14)CO(2) in C-4 of oxaloacetate, malate and aspartate, was examined under varied conditions. 2. The pattern of labelling was essentially the same with leaves of different ages and with leaves equilibrated at carbon dioxide concentrations in the range 0-3.8% (v/v) and light-intensities in the range 1400-9000ft.-candles before adding (14)CO(2). 3. Radioactive products were examined after exposing leaves of 33 different plant species to (14)CO(2) for 4sec. under standard conditions. 4. A labelling pattern typical of sugar-cane was found in several species of Gramineae but not in others. Of 16 species from other Families only a species of Cyperaceae contained a large proportion of the fixed radioactivity in oxaloacetate, malate and aspartate.


Partial characterization of protocollagen from embryonic cartilage. 1. Attempts were made to isolate and characterize the protocollagen that accumulates in connective tissue when the hydroxylation of proline and lysine is inhibited. The term protocollagen has been used to describe the proline-rich and lysine-rich polypeptide or polypeptides that serve as substrates for the formation of hydroxyproline and hydroxylysine during the synthesis of collagen. 2. Both protocollagen and newly synthesized collagen from embryonic cartilage were isolated as complex aggregates, which contained sulphated mucopolysaccharides and other proteins or polypeptides from the same tissue. The complexes containing protocollagen were similar to those containing newly synthesized collagen when examined with several different techniques. 3. After the complexes were denatured and disaggregated, zone centrifugation and gel filtration indicated that the denatured protocollagen was similar to the denatured newly synthesized collagen obtained from cartilage in which the hydroxylation was not inhibited, and it was also similar to purified alpha-collagen. The results suggest that, when the hydroxylation is inhibited, most of the protocollagen polypeptides that accumulate are as large as complete alpha-chains of collagen. 4. Significant purification of the protocollagen polypeptides was obtained with a new technique for DEAE-Sephadex chromatography in which urea was used to prevent aggregation of the samples and the column was eluted with guanidine thiocyanate. 5. Protocollagen polypeptides were completely hydrolysed to diffusible peptides by a specific collagenase. 6. It is not entirely clear whether the hydroxylation normally begins while relatively short protocollagen molecules are still attached to polysomes, or whether protocollagen molecules of the size of alpha-collagen are synthesized even when the hydroxylation is not inhibited. 7. Results obtained with puromycin suggest that some hydroxylation occurs with smaller polypeptides, but polypeptide chains approaching the size of alpha-collagen are required to obtain complete hydroxylation of the appropriate amino acid residues of protocollagen.


Characterization of the hexahydropolyprenols of Aspergillus fumigatus Fresenius. The isolation and properties of a group of alcohols from the mycelium of Aspergillus fumigatus Fresenius are described. Mass-, nuclear-magnetic-resonance- and infrared-spectrometric studies coupled with evidence from ozonolytic degradation and chromatography show the mixture to contain hexahydroprenols-18, -19, -20, -21, -22, -23 and -24. Each contains a saturated ;hydroxy-terminal' isoprene residue, a saturated omega-terminal isoprene residue and a saturated zeta-isoprene residue (adjacent to the omega-residue). The presence of only two trans-isoprene residues is also a feature of the series of alcohols, but the precise position of these in each molecule is not known.


Lipid composition and metabolism in testicular and ejaculated ram spermatozoa. 1. Spermatozoa collected directly from the testis of the conscious ram contain 25% more phospholipid than ejaculated spermatozoa. The concentration of lecithin, phosphatidylethanolamine and ethanolamine plasmalogen was greater in testicular spermatozoa; little difference was observed in choline plasmalogen. Both types of spermatozoa had significant amounts of cardiolipin and alkyl ether phospholipid. 2. The fatty acids in the phospholipid extracted from testicular spermatozoa have a very high content of palmitic acid. The phospholipids of ejaculated spermatozoa contained less palmitic acid, but more myristic acid. 3. Ejaculated spermatozoa contained less acyl ester and cholesterol. It is suggested that lipids are a source of substrate for spermatozoa during their passage through the epididymis. 4. Testicular spermatozoa when incubated with [U-(14)C]glucose incorporated more radioactivity into the glycerol part of the phospholipid and neutral lipid fractions than did ejaculated cells. The distribution of radioactivity in the individual phospholipids and neutral lipids was similar for both cell types. No radioactivity was detected in choline plasmalogen, which accounted for approx. 40% of the total phospholipid. 5. Testicular spermatozoa incorporated more radioactivity from glucose into formate than into acetate, whereas a higher proportion of radioactivity was found in acetate in ejaculated cells. 6. The implications of these lipid changes in the process of spermatozoal maturation are discussed.


The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol. 1. The syntheses of Delta(7)-[4-(14)C]cholestenol (XVI, Scheme 3) and Delta(7)-[6alpha-(3)H]-cholestenol (XII, Scheme 2) are described. 2. The metabolism of doubly labelled Delta(7)-cholestenol (II, Scheme 1) by rat-liver homogenates was studied. 3. During the enzymic conversion of Delta(7)-cholestenol into cholesterol (IV, Scheme 1) the 6alpha-hydrogen atom of the former is lost and the overall reaction corresponds to a cis-elimination. 4. In the light of these results various mechanisms for the conversion of Delta(7)-cholestenol into cholesterol are discussed.


Reaction of myoglobin with 3,3-tetramethyleneglutaric anhydride. 1. The extent of reaction of the protein with 3,3-tetramethyleneglutaric anhydride was measured by determining the loss of lysine and the equivalent appearance of 3,3-tetramethyleneglutarimidolysine in the hydrolysate at various time-intervals. Of the 19 lysine residues in sperm-whale myoglobin, three did not react with 3,3-tetramethyleneglutaric anhydride. Also, the N-terminal valine did not react. 2. Slight spectral changes were observed on modification of myoglobin. 3. Electrophoretic changes were great since the derivative was negative throughout the range pH6-8.8. 4. The derivative did not react with antisera to native sperm-whale myoglobin.


Enzymic oxidation of some alkylbenzenes in insects and vertebrates. 1. Oxidation rates of alkylbenzenes have been measured in 10000g supernatants of vertebrate livers, locust fat bodies and housefly abdomens. 2. Activity per g. of insect was greater in fly than locust preparations but both were of the same order as a range of vertebrate species. 3. Methyl groups of toluene and p-nitrotoluene were oxidized more rapidly than the side chains of higher homologues. 4. In the higher homologues hydroxylation occurred most readily at the alpha-methylene group and less readily at penultimate methylene and terminal methyl groups. 5. Oxidations in both vertebrates and insects were inhibited by piperonylbutoxide and similar synergists. 6. Oxidation activity was stimulated by pretreatment of rats, but not locusts, with phenobarbitone or 3,4-benzopyrene.


Oxidation of methyl groups by grass grubs and vertebrate liver enzymes. 1. Oxidation rates of p-nitrotoluene, p-acetamidotoluene and p-toluidine by intact grass grubs and vertebrate liver preparations were measured. 2. The effect of p-substitution in increasing the rate of conversion of the methyl into a carboxy group was in the order acetamido> nitro[unk] amino in mice and grass grubs. 3. Rates of oxidation of the N-methyl group in some alkylaryl N-methylcarbamates was measured and the effect of ring substituents in increasing the rate was in the order hydrogen> o-methyl or o-isopropyl> p-methyl or p-isopropyl> m-methyl or m-isopropyl. 4. Rates of oxidation of the N-methyl groups were similar to those of the p-substituted toluenes.


Amino ketone formation and aminopropanol-dehydrogenase activity in rat-liver preparations. 1. Rat tissue homogenates convert dl-1-aminopropan-2-ol into aminoacetone. Liver homogenates have relatively high aminopropanol-dehydrogenase activity compared with kidney, heart, spleen and muscle preparations. 2. Maximum activity of liver homogenates is exhibited at pH9.8. The K(m) for aminopropanol is approx. 15mm, calculated for a single enantiomorph, and the maximum activity is approx. 9mmumoles of aminoacetone formed/mg. wet wt. of liver/hr.at 37 degrees . Aminoacetone is also formed from l-threonine, but less rapidly. An unidentified amino ketone is formed from dl-4-amino-3-hydroxybutyrate, the K(m) for which is approx. 200mm at pH9.8. 3. Aminopropanol-dehydrogenase activity in homogenates is inhibited non-competitively by dl-3-hydroxybutyrate, the K(i) being approx. 200mm. EDTA and other chelating agents are weakly inhibitory, and whereas potassium chloride activates slightly at low concentrations, inhibition occurs at 50-100mm. 4. It is concluded that aminopropanol-dehydrogenase is located in mitochondria, and in contrast with l-threonine dehydrogenase can be readily solubilized from mitochondrial preparations by ultrasonic treatment. 5. Soluble extracts of disintegrated mitochondria exhibit maximum aminopropanol-dehydrogenase activity at pH9.1 At this pH, K(m) values for the amino alcohol and NAD(+) are approx. 200 and 1.3mm respectively. Under optimum conditions the maximum velocity is approx. 70mmumoles of aminoacetone formed/mg. of protein/hr. at 37 degrees . Chelating agents and thiol reagents appear to have little effect on enzyme activity, but potassium chloride inhibits at all concentrations tested up to 80mm. dl-3-Hydroxybutyrate is only slightly inhibitory. 6. Dehydrogenase activities for l-threonine and dl-4-amino-3-hydroxybutyrate appear to be distinct from that for aminopropanol. 7. Intraperitoneal injection of aminopropanol into rats leads to excretion of aminoacetone in the urine. Aminoacetone excretion proportional to the amount of the amino alcohol administered, is complete within 24hr., but represents less than 0.1% of the dose given. 8. The possible metabolic role of amino alcohol dehydrogenases is discussed.


Regulation of xanthine dehydrogenase in chick liver. Further experiments on the effects of inosine, actinomycin D and other factors. 1. It has been confirmed that the xanthine-dehydrogenase activity of chick liver is enhanced by starvation and by administration of inosine; the effects of these treatments are not additive. 2. Inosine has no effect when given to chicks depleted of the enzyme by feeding a low-protein diet. 3. Actinomycin D prevents the effect of inosine, but itself enhances the activity of xanthine dehydrogenase. 4. The xanthine-dehydrogenase activity is unchanged after addition of orotic acid to the diet, and is stimulated by injection of inorganic iron.


Separation and properties of beta-galactosidase, beta-glucosidase, beta-glucuronidase and N-acetyl-beta-glucosaminidase from rat kidney. 1. The activities of beta-galactosidase, beta-glucosidase, beta-glucuronidase and N-acetyl-beta-glucosaminidase from rat kidney have been compared when 4-methylumbelliferyl glycosides are used as substrates. 2. Separation by gel electrophoresis at pH7.0 indicated slow- and fast-moving components of rat-kidney beta-galactosidase. 3. The fast-moving component is also associated with the total beta-glucosidase activity and inhibition experiments indicate that a single enzyme species is responsible for both activities. 4. DEAE-cellulose chromatography and filtration on Sephadex gels suggests that the beta-glucosidase component is a small acidic molecule, of molecular weight approx. 40000-50000, with optimum pH5.5-6.0 for beta-galactosidase and beta-glucosidase activities. 5. The major beta-galactosidase component has low electrophoretic mobility, a calculated molecular weight of 80000 and optimum pH3.7.


Rat-urine glycosidases and kidney damage. 1. The activities of beta-galactosidase, beta-glucosidase, beta-glucuronidase and N-acetyl, beta-glucosaminidase were estimated in normal and pathological rat urine, with 4-methylumbelliferyl glycosides as substrates. 2. Kidney damage induced by injections of uranium nitrate, mercuric chloride, potassium dichromate or 4-nitrophenylarsonic acid causes a marked increase in the urinary excretion of all four enzymes. 3. The rise in beta-glucosidase activity was associated with the appearance of a new urinary enzyme species, which was examined by starch-gel electrophoresis, DEAE-cellulose chromatography and filtration on Sephadex G-75 and G-200. 4. This enzyme appears to be identical with its counterpart in the kidney, and it is suggested that it arises in the urine as a result of renal tubular breakdown. 5. The other glycosidases examined also show some physical similarities to the corresponding enzymes of the rat kidney.


Countercurrent-distribution studies on histones. 1. The possibilities of fractionating histones and histone fractions by means of countercurrent distribution between two phases formed by water and butan-2-ol, in the presence of various concentrations of trichloroacetic acid, have been examined. 2. Although the principal histone fractions differ considerably in their partition ratios, a satisfactory resolution of the principal histone fractions from the whole histone has not been achieved. 3. The histone fractions obtained by other methods can be resolved with suitable concentrations of trichloroacetic acid. Besides the main peak several subsidiary peaks are obtained in most cases, the composition of which corresponds with others of the main fractions. 4. The method is therefore capable of removing from the principal fractions as previously prepared contamination by other fractions. 5. Except in one case, no fraction with composition unlike other fractions has been obtained. In several cases the material isolated from the principal peak behaves as a single component on running again. In two cases fractions with similar compositions were distinguished by countercurrent distribution.


Further studies on the biosynthesis of gramicidin  S and proteins in a cell-free system from Bacillus brevis. 1. An improved 11000g cell-free system for the incorporation of [(14)C]valine into gramicidin S has been obtained. The cell-free extract used was the supernatant obtained by treating Bacillus brevis with ultrasonics for 1min. followed by centrifugation at 11000g. The optimum pH for the incorporation was 8.2-8.4 and the optimum Mg(2+) concentration 0.05m. The presence of ammonium sulphate (0.1m) and K(+) (0.01m) increased the incorporation. 2. Cell-free extracts prepared from cells harvested in the early phase of growth (extinction value 0.1) incorporated negligible amounts of [(14)C]valine into gramicidin S compared with that incorporated by cell-free extracts prepared from cells harvested in the late phase of growth (extinction value 0.5). This was not due to the presence of inhibitors in the cell-free extracts prepared from cells harvested early, since there was no marked decrease in gramicidin S synthesis in a mixture of extracts prepared from cells harvested early and late in the growth phase. 3. The small incorporation of [(14)C]valine into protein, which took place in cell-free extracts from cells harvested in the late growth phase, was not inhibited by puromycin, chloramphenicol and ribonuclease. However, the substantial incorporation that took place in cell-free extracts prepared from cells harvested in the early phase of growth was completely inhibited by puromycin, chloramphenicol and ribonuclease. On mixing cell-free extracts prepared from cells harvested early and late in the growth phase, it appeared that the small incorporation that occurs in extracts from cells harvested in the late phase of growth was not due to cellular inhibitors.


A diagonal electrophoretic method for selective purification of methionine peptides. 1. A method is described that selectively purifies methionine peptides from enzymic digests of a protein. The peptides, after paper electrophoresis, are treated on paper with iodoacetamide at acid pH. This specifically converts methionine residues into their sulphonium salts. When the paper is submitted to electrophoresis at right angles to the original direction, the carbamoylmethylmethionine peptides emerge from an undifferentiated diagonal. 2. Heating at neutral pH converts carbamoylmethylmethionine into homoserine and thereby specifically cleaves the peptides. 3. The effect of the modifications on amino acid composition and sequence analyses of the peptides was studied. 4. When the method was applied to a tryptic digest of S-aminoethyl-chymotrypsinogen A, two peptides were selectively purified that had the expected amino acid sequence.


Pathways of retinol and retinoic acid metabolism in the rat. 1. The metabolism of retinoic acid and retinyl acetate labelled with (14)C in various positions was studied after intravenous injection of physiological amounts of these compounds into retinol-deficient rats. 2. Analysis of the resultant radio-activity in the urine, carbon dioxide and faeces led to a postulation of the existence of three major pathways for the metabolism of these two compounds. 3. Evidence is presented that retinoic acid and retinol are metabolized by either the same or at least similar pathways and that retinol becomes oxidized to the carboxyl state before any degradation of the isoprenoid side chain occurs. 4. It is not possible to decide from these data whether retinoic acid is an intermediate in the retinol pathway. 5. Possible sites for the regulation of retinol metabolism are discussed.


Formation of retinoic acid from retinol in the rat. 1. The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered [15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct-cannulated rats. 4. Excretion of unaltered retinoic acid in the urine of intact rats did not occur even after the intrajugular administration of preformed retinoic acid.


Permeability of rat diaphragm muscle to some methyl glycosides and its relationship to monosaccharide transport. 1. Studies in vitro have shown that rat diaphragm muscle is freely permeable to alpha- and beta-methyl d-xylosides and beta-methyl l-arabinoside but not to alpha- or beta-methyl d-glucoside or alpha-methyl d-mannoside. 2. No competition for entry between methyl pentosides and d-xylose, l-arabinose, d-glucose or 3-O-methyl-d-glucose could be demonstrated and alpha-methyl xyloside entry was not inhibited by phlorrhizin. 3. It is concluded that the monosaccharide transport system is unlikely to contribute significantly to the entry of the methyl pentosides in this tissue.


The importance of glucose in the oxidative metabolism of the testis of the conscious ram and the role of the pentose cycle. 1. [U-(14)C]Glucose was infused into one or both testicular arteries of ten conscious rams and the specific activity of the glucose taken up by the testis was compared with the specific activity of the carbon dioxide produced by the testis. 2. Equilibration had occurred after infusion for 3hr. when a mean of 68% of the carbon dioxide was being derived by the testis from blood glucose and 86% of the glucose taken up by the testis was being oxidized to carbon dioxide. After 5hr. infusion, these values were 71% and 83% respectively. 3. In four other conscious rams, [1-(14)C]glucose was infused into one testicular artery and [6-(14)C] glucose into the other and the ;specific yields' of carbon dioxide calculated for the two forms of glucose. 4. From these values, it was calculated that a mean of 9.3% of the glucose taken up by the testis was metabolized via the pentose cycle.


Phosphate and thiol groups in histone f3 from rat liver and thymus nuclei. 1. Differences in washing procedures and conditions of dialysis affected the type of histone f3 obtained from rat liver and thymus nuclei. 2. Sulphur-rich preparations of f3 contained phosphate and had SH+SS: phosphorus ratio 1:2. 3. Sulphur-rich f3 from livers of [(14)C]adenine-labelled rats gave counts indicating a phosphorus: adenine ratio 1:1. 4. Evidence was presented that histones f3 and f1 exist in nuclei as families of proteins, differing with respect to their sulphur or phosphorus content or both. 5. The significance of the different states of phosphorylation and oxidation of histones f1 and f3 was discussed.


A survey of vitamin B-12 deficiency in an elderly psychiatric population.


Vitamin B-12 deficiency and psychiatric illness.


Gastric "hunger" contractions in anorexia nervosa.


Mood and behavioural changes with progestational agents.


The effects of LSD on body sway suggestibility in a group of hospital patients.


Neuroticism and extraversion in ABO blood groups.


A study of pairs of sibs both hospitalized for mental disorder.


Body build and urinary steroid excretion in mental illness.


Psycho-analytical psychotherapy in the National Health Service.


The ecology of suicidal behaviour.

The ecology of suicidal behaviour.


The psychiatric service at Birmingham University.


Side-effects of phenothiazines.

Side-effects of phenothiazines.


Ocular motility and hemiplegia.

Ocular motility and hemiplegia.


Visual field disturbances associated with hemiplegia.


Disturbances of the higher visual functions.


Studies of dark adaptation of discrete paracentral retinal areas. I. Method.


Studies of dark adaptation of discrete paracentral retinal areas. II. Normal eyes 5 degrees, 15 degrees and 30 degrees from fixation.


The consensual tonographic effect in normal and glaucomatous adults.


Congenital nystagmus.

Congenital nystagmus.


Results of filtering operations for glaucoma.


Early case finding and the hereditary factor in strabismus.


The dynamics of change in psychotherapy.


The diagnosis and treatment of borderline schizophrenia in adolescence.


Intensive psychotherapy of schizophrenia. An initial interview.


A dynamic thematic-experimental approach in the treatment of mental subnormality. A preliminary report on an experiment in educational therapy.


The use of brief psychotherapy with children.


The origin and growth of the day hospital.


A study of the psychiatric interview.

A study of the psychiatric interview.


Munchausen's syndrome. A  note on schizoid mechanisms.


Toxic psychosis due to antiparkinsonian drugs.


The selection of delusional persecutors.


Teaching pediatrics in practitioners' offices.


Autistic behaviour patterns in phenylketonuric children.


How necessary is the "routine check-up"?


Fabrics and accidental burns.

Fabrics and accidental burns.


Functional role activities of the private practitioner. A method of investigating office practice and time study of the typical day of 25 physicians.


Chemical pneumonitis from medicated vapor aerosol spraying.


Approaches to child rearing: early recognition and modification of vicious-circle parent-child relationships.


Tolbutamide orinase in human breast milk.


Specific learning disabilities. I. Medical aspects.


Specific learning disabilities. II. Psychosocial aspects.


Malnutrition in early childhood: the newer insights.


Pulmonary gas exchange and hemodynamics in patients with recurrent pulmonary embolism and polycythemia vera.


Experimental atherosclerosis in rabbits with motility restriction.


The external carotid pulse wave in aortic stenosis.


Histology of vasoconstriction and vasodilatation of muscular arteries by the freeze-drying method.


Toxicological studies with a hydrocarbon solvent, SBP 62/82.


Studies of brown FK. I. Composition and synthesis of components.


Comparative survey of lead at selected sites in the British Isles in relation to air pollution.


Sufficient challenge.

Sufficient challenge.


Chemical studies on tobacco smoke. II. Comparison of the yields of several selected components in the smoke from five major Turkish tobacco varieties.


The value of estimations of foetal blood in severe Rh-immunization cases.


Radiation hazards and radiation safety standards in manned space operations.


Live-time and half-life control of scanner for whole-body radiation counter.


Cesium-137 in Alaskan lichens, caribou and eskimos.


Factors influencing radiostrontium accumulation in Daphnia.


Radon film badge.

Radon film badge.


The effect of various dietary calcium levels on the elimination of strontium-89.


A floor monitor for alpha contamination.


A data transfer system for the digital analysis of thermoluminescent spectra.


Hazards of flight in the supersonic transport.


Determination of some trace elements in human serum-albumin by neutron-activation analysis.


Irradiation of estrone in aqueous solutions.


Preservation of cheese with combined use of gamma-rays and sorbic acid.


Assay of Ca45 in biological materials by liquid scintillation counting.


New colloidal chromic radiophosphate (P32) for local irradiation of the central nervous system.


Instrumental radioactivation analysis of selenium in biological materials.


A liquid-scintillation technique for the radioassay of calcium-45.


Technetium-99-m macroaggregated albumin: a new lung scanning agent.


On the use of thymidine H-3 in tissue culture.


Specific and permanent deficits in instrumental avoidance responding following forebrain ablation in the goldfish.


Influence of strychnine on classically conditioned defensive reflexes in the cat.


Effect of intracerebral actinomycin D and of electroconvulsive shock on passive avoidance.


Instrumental learning of heart rate changes in curarized rats: shaping, and specificity to discriminative stimulus.


Thresholds for thermal stimulation of the inner thigh, footpad, and face of cats.


Genotype and conditioned avoidance learning in the mouse.


Reinforcement value of water and hypotonic saline in discrete trial situations.


Hoarding and inbred strains of mice.

Hoarding and inbred strains of mice.


Effect of reduced cholinesterase activity on the maintenance of an operant response.


Extinction of conditioned fear as a function of percentage of reinforcement.


Loss of auditory pattern discrimination following insular-temporal lesions in cats.


Visual intensity discrimination in pigeons following unilateral and bilateral tectal lesions.


Modification of a visceral response, salivation in thirsty dogs, by instrumental training with water reward.


Slow potential change in human brain related to level of motivation.


Inversion of discrete trial water-saline preference as a function of prior drinking experience.


Effects of inescapable shock upon subsequent escape and avoidance responding.


Discrimination based on differential nonshock confinement in a shuttle box.


Response suppression as a function of intensity and duration of a punishment.


Frustration-suppression effect in a discrete-trial operant situation.


Resistance to extinction in the runway following a shift from small to large reward.


Positional matching in rats and fish.

Positional matching in rats and fish.


Number of responses as a stimulus in fixed interval and fixed ratio schedules.


Genetic analysis of geotaxis in Drosophila melanogaster: complementation between forward and reverse selection lines.


Socially facilitated reduction of the feat response in rats raised in groups or in isolation.


Albinism and avoidance learning in mice.


Instrumental conditioning of the heart rate in the curarized rat.


Age, food deprivation, nonnutritive sucking, and movement in the human newborn.


Cardiac responsiveness and differential conditioning.


Acquisition of avoidance behavior following septal lesions in the rat.


Variability in mallomonas.

Variability in mallomonas.


The influence of dissolved oxygen concentration on the respiration and glucose metabolism of Klebsiella aerogenes during growth.


Kinetic aspects of the growth of Klebsiella aerogenes with some benzenoid carbon sources.


Path of glucose breakdown and cell yields of a facultative anaerobe, Actinomyces naeslundii.


Serum mediated killing of three group D salmonellas.


The growth and metabolic versatility of the gram-negative Bacterium NCIB 8250 ("Vibrio 01").


Computer analysis of Acinetobacter iwoffi (Moraxella iwoffii) and Acinetobacter anitratus (Moraxella glucidolytica) strains.


The activation of spores of Clostridium bifermentans.


An electron microscope study of dinoflagellate flagella.


Studies of bromouracil deoxyriboside substitution in DNA of bean roots (Vicia faba).


A determination of mutagen specificity in bacteria using nonsense mutants of bacteriophage T4.


Evidence suggesting a non-random character to nucleotide replacements in naturally occurring mutations.


Studies on microbial ribonucleic acid. IV. Two mutants of Saccharomyces cerevisiae lacking N-2-dimethylguanine in soluble ribonucleic acid.


Conformational change of tyrosyl-RNA synthetase induced by its specific transfer RNA.


Stability of 5s ribonucleic acid in mammalian cells.


The C. O. Sappington Memorial Lecture 1967. Education for occupational medicine.


Examining the individual in relation to his environment.


Effects of atmospheric contamination on cancer mortality in petroleum refinery employees.


Ann Arbor Case Reports. Cutting and grinding fluids in chronic pulmonary airway disease.


A quantitative study of leucocyte emigration in chronic inflammatory granulomata.


Identity of a disputed, haemophilus-like organism in non-specific vaginitis.


The electron microscopy of parabiotic renal amyloid.


Detection of mycoplasma in cell cultures.


Observations on experimental oral infection with Salmonella dublin in calves and Salmonella choleraesuis in pigs.


The effect of cirrhosis and ethanol ingestion on hepatic iron deposition in the rat.


Lysosome changes in acute liver injury due to heliotrine.


Structure of the gall bladder.

Structure of the gall bladder.


The pathology of Clonorchis sinensis infestation of the pancreas.


The microcirculatory effects of dextran.


The pathology of the adrenal gland in Cushing's syndrome.


Electron-microprobe analysis of calcium phosphorus and sulphur in human arteries.


Histological changes produced by experimental erythrocyte aggregation.


The effect of oxygen on experimental tumour growth in the liver and spleen.


The nature and properties of the haemagglutinin of Clostridium septicum.


Microthrombosis in injured and burned patients.


Ultrastructure of the livers of rats bearing transplanted tumours.


Mixed mesodermal tumours of the ovary.

Mixed mesodermal tumours of the ovary.


Adenomatosis in Bowman's capsule in primary liver cancer.


The utilisation of proline by the sinusoidal cells of mouse liver damaged by hepatotoxic agents.


The effect of suppression of endogenous thyroid-stimulating hormone secretion on experimental allergic thyroiditis in the guinea-pig.


Hyperplasia of the thymus in progressive systemic sclerosis.


Isolation and culture of human macrophages from the living and the dead.


Role of mycoplasma infection in the development of experimental bronchiectasis in the rat.


Chondrosarcoma with long-delayed metastasis of unusual distribution.


Atypical mycobacterium in tuberculosis-like lesions in wood pigeons.


Regeneration of crushed mammalian skeletal muscle and effects of steroids.


Ultrastructure of globule leucocytes in immune rats infected with Nippostrongylus brasiliensis and their possible relationship to the Russell body cell.


Kinetics of replication of copolymeric DNA.


Two-factor models, neural nets and biochemical automata.


Application of the lattice gas theory to lipid monolayers.


Interlayer-interaction for a lipid bilayer model.


Some modern radium applicators and treatment policies for cancer of the cervix.


Endocardial and epicardial pacemaking in the management of heart block.


Problems in tetanus prophylaxis: the immune patient.


The overuse syndrome in athletes.

The overuse syndrome in athletes.


Ruptured false aneurysm of the splenic artery.


A study of the personality of voluntary blood donors.


Communications in medicine: the printed word. I.


Programmed learning in medical instruction.


Mathematical interpretation of heart kymography.


Action of atomic hydrogen on ribonuclease in aqueous solution.


A reversible inhibitor of nucleic acid synthesis.


Growth regulatory effects of cellular interaction.


Biochemical evidence for a distinct type of primary gout.


Acetate repression of chlorophyll synthesis in Euglena gracilis.


Dependence of uptake of succinate by mitochondria on energy and its relation to potassium retention.


Isoamylases of human parotid saliva.

Isoamylases of human parotid saliva.


Radiommunoassay of bradykinin.

Radiommunoassay of bradykinin.


Membrane filtration for determining protein in the presence of interfering substances.