Modification of thrombus formation on prosthetic heart valves by the administration of low molecular weight dextran.


Superiority of buffered Ringer's lactate to heparinized blood as total prime of the large volume disc oxygenator.


Jaundice following open-heart surgery.

Jaundice following open-heart surgery.


Factors necessary for successful replantation of upper extremities.


Cellular swelling: 3. Effects of hypothermia and addition of low molecular weight dextran on oxygen consumption and electrolyte composition of isolated tissues.


Size of the common bile duct following cholecystectomy.


Right hepatectomy for hamartoma in an eleven-month-old infant: a case report.


Distinction between pseudocysts of the head of the pancreas and carcinoma of the pancreas.


Effect of chronic hypercapnia on gastric secretion in the dog.


Surgical implications of the Peutz-Jeghers syndrome.


A comparative environmental investigation of surgeons' skin germicides.


Acute afferent loop obstruction.

Acute afferent loop obstruction.


The deposition and clearance of radioactive particles in the human lung.


Spontaneous resolution of traumatic subclavian steal syndrome.


The photochemical air pollution syndrome. Exhibited by attack of October 1965.


Social and environmental factors in respiratory disease. A preliminary report.


The relationship of air pollution and economic status to total mortality and selected respiratory system mortality in men. I. suspended particulates.


Health and the urban environment. V. Air pollution and illness in a normal urban population.


Air pollution and meteorologic factors. Effects on normal subjects and patients with respiratory disease.


Cigarette smoking and the lungs. Relation to postmortem evidence of emphysema, chronic bronchitis, and black lung pigmentation.


The effects of occupation on chronic respiratory disease.


Biostatistical aspects of the air pollution-health problem.


The geographic pathology of pulmonary emphysema and chronic bronchitis. II. Subjective assessment of emphysema.


Air pollution medical research conference. Summarization of conference.


Clinical implications of basic research in air pollution.


Air pollution and chronic bronchitis.

Air pollution and chronic bronchitis.


Air pollution medical research conference. Over-view.


Application of basic approaches to field studies.


Air pollution. A problem for human ecology.


Meteorological aspects of air pollution. Their relationship to biological responses.


The irritant potential of pollutants in the atmosphere.


The physiological basis of common pulmonary function tests.


Lung surfactant and its possible reaction to air pollution.


Cilia and mucus transport as determinants of the response of lung to air pollutants.


Metabolic and immunologic activities of alveolar macrophages.


Preventive aspects of minor wounds.

Preventive aspects of minor wounds.


Community health impact of the space industry.


Group methods in smoking withdrawal.

Group methods in smoking withdrawal.


Cigarette smoking and thrombotic coagulation of human blood. Further in vitro studies.


Attitudes of physicians entering military service.


Measuring chronic illness morbidity.

Measuring chronic illness morbidity.


Commercial talc and talcosis.

Commercial talc and talcosis.


Toxicology of Abate in laboratory animals.


Evaluation of atypical mycobacteria in an outpatient clinic.


Enhanced potassium loss in blood cells from men exposed to lead.


Influence of carbon disulfide on the eye.


The digital computer and public health.

The digital computer and public health.


Medical aspects of sustained underwater exploration.


The management of industrial injuries. The internist's role.


A current appraisal of drug therapy of atherosclerosis.


Health programs in the Ryukyu islands.

Health programs in the Ryukyu islands.


Quo vadis, occupational medicine.

Quo vadis, occupational medicine.


Attempted suicide with herbicide containing MCPA.


Cigarette smoke and ciliastasis.

Cigarette smoke and ciliastasis.


Anaphylactic shock in man. Report of two cases with detailed hemodynamic and metabolic studies.


Lead-containing particles.

Lead-containing particles.


Pulmonary alveolar proteinosis. Treatment by massive bronchopulmonary lavage.


Cross-allergenicity of the penicillins and the cephalosporins.


Percutaneous renal biopsy. An improved method using television monitoring and high-dose infusion pyelography.


Percutaneous needle biopsy of the lung.

Percutaneous needle biopsy of the lung.


Diabetes mellitus. A review of mortality experience.


Arizona infection of man. Report of a case and review of the literature.


The heart in myotonia atrophica.

The heart in myotonia atrophica.


Furosemide, a new diuretic in edematous states. Clinical studies in patients with congestive heart failure and cirrhosis of the liver.


Staphylococcal endarteritis in a renal artery-inferior vena cava fistula.


Intestinal lymphangiectasia with response to corticosteroids.


Systemic lupus erythematosus associated with pulmonary nocardiosis.


Giant ulcer of the face following surgery for trigeminal neuralgia.


Prevalence of chronic respiratory disease in a pulp mill and a paper mill in the United States.


Chronic bronchitis in miners and non-miners: an epidemiological survey of a community in the gold-mining area in the Transvaal.


Ventilatory function in relation to mining experience and smoking in a random sample of miners and non-miners in a Witwatersrand Town.


A noise-attenuating enclosure for audiometer earphones.


Effects of histamine aerosol in byssinotic subjects.


Heat-protective ventilated jackets: a comparison of humid and dry ventilating air.


Long-term efficacy of oil-adjuvant influenza vaccine in an industrial population.


Determination of the carboxyhaemoglobin saturation of blood by spectrophotometric analysis.


Further investigations on the evaluation of exposure to nitrobenzene.


Mercury poisoning and its treatment with N-acetyl-D, L-penicillamine.


Antilymphocyte serum.

Antilymphocyte serum.


An inorganic mercury hazard in the manufacture of artificial jewellery.


Hirschsprung's disease in infancy.

Hirschsprung's disease in infancy.


Improving medical communication.

Improving medical communication.


Tangled bill.

Tangled bill.


Management of acute poisoning.

Management of acute poisoning.


Metabolism of lactose by intestinal mucosa from normal and lactase-deficient subjects.


Field studies of human stress in Polar Regions.


Behaviour disorders and pattern of crime among XYY males identified at a maximum security hospital.


Lactase activity in newborn and infant Baganda.


Urinary leucocyte excretion in African subjects: its relation to bacteriuria and the passage of bilharzial ova in urine.


Urinary infection presenting with jaundice.


Case of cobalt poisoning.

Case of cobalt poisoning.


Prevention of regurgitation during induction of anaesthesia with a cuffed oesophageal catheter.


Food or drug.

Food or drug.


Medical contraindications to oral contraceptives.


Squamous carcinoma of the thoracic oesophagus in malabsorption syndrome.


Relation between antibody and insulin dose.


Combining hypotensive drugs.

Combining hypotensive drugs.


A "fail safe" oxygen device.

A "fail safe" oxygen device.


Medicine and politics.

Medicine and politics.


Tissue and organ transplantation.

Tissue and organ transplantation.


Psychiatric sequelae of termination of pregnancy.


Cephaloridine and staphylococcal endocarditis.


Dependence on dextromoramide.

Dependence on dextromoramide.


A screening test for Wilson's disease and its application to psychiatric patients. Varied modes of onset make the early diagnosis of Wilson's disease difficult. A deficiency of serum ceruloplasmin, usually characteristic of the disease, was used as the basis for a screening test. Simple test materials and provision for handling about 50 plasma samples simultaneously made this test feasible for large-scale screening.The screening test was applied to 336 persons hospitalized for psychiatric disorders, to detect patients with Wilson's disease before the classical symptoms appeared. Two patients with ceruloplasmin levels below the normal limits were detected but did not have Wilson's disease. Further application of the screening test to relatives of patients known to have Wilson's disease and to individuals with any symptoms of the disease (hepatic disease, extrapyramidal dysfunction, psychiatric disorders, behaviour problems in children) would aid in early diagnosis and more effective treatment.


Diagnostic indices in acute renal failure. The urine/plasma creatinine ratio (U/P Cr), the urine sodium concentration (UNa), and the diuretic response to mannitol infusion in 23 patients were reviewed in an attempt to differentiate functional renal failure (FRF) from acute tubular necrosis (ATN). FRF was diagnosed if the plasma urea nitrogen (PUN) or serum creatinine stabilized within 72 hours. When renal failure persisted longer, patients had ATN. Subjects dying within 72 hours were excluded. Ten patients had ATN and five survived. The minimum duration of renal failure among survivors was 10 days. None responded to mannitol. Of 13 patients with FRF, 11 survived. Seven of 12 who received mannitol responded with a diuresis. The mean UNa in the patients with ATN was 51.4 mEq./1. +/- 9.48 (SE). The mean U/P Cr was 11.2 +/- 1.12. In patients with FRF, the mean UNa was 14.0 mEq./1. +/- 4.2 and the mean U/P Cr was 42.5 +/- 11.5. A significant overlap was present between the two groups. When UNa was factored by the U/P Cr, the resultant ratio was significantly different for the two groups of patients (P < 0.01), and this proved to be a useful clinical index with which to distinguish FRF from established ATN.


The utilization of long nylon catheters for prolonged intravenous infusions. A study of 300 patients receiving intravenous therapy showed that 90 had associated phlebitis. Because of this high rate of complications, the use of long plastic catheters, with the tip located in a large central vessel, was investigated. One hundred and one catheters were inserted into the basilic vein through a cut-down. The patients were divided into four groups: infusions lasting one to seven days, eight to 14 days, 15 to 28 days and 29 days or longer. The most common complication was obstruction of the catheter with clotted blood. In four patients the catheters had to be removed because of phlebitis; two were pulled out by the patients themselves. Infection was not observed. Two factors probably contributed to the successful infusions: the composition of the plastic catheters (nylon) and the location of the tip in a large central vessel.


Consent for treatment.

Consent for treatment.


Medical care of Eskimo children.

Medical care of Eskimo children.


Drug dependency research--expensive luxury or necessary commodity?


Outpost nursing.

Outpost nursing.


Use of narcotics in addict therapy.

Use of narcotics in addict therapy.


Care of patients addicted to non-narcotic drugs.


Serum enzymes in patients with carcinoma of lung: lactic-acid dehydrogenase, phosphohexose isomerase, alkaline phosphatase and glutamic oxaloacetic transaminase. Serial determinations of serum lactic-acid dehydrogenase (LDH), phosphohexose isomerase (PHI), alkaline phosphatase (AP), and glutamic oxaloacetic transaminase (GOT) were carried out in 30 patients with primary and four with secondary neoplasms of the lung. Enzyme values were correlated with the stage of illness, with tumour histology, with chemotherapy and with the extent and site of metastases as determined at autopsy. The activity of the enzymes LDH and PHI was most frequently elevated; their values correlated closely. AP and GOT tended to become elevated only shortly before death. Although, in general, enzyme activity increased with tumour extension and often in relation to chemotherapy, assays provided little assistance in early diagnosis or prognosis except that, in most instances, elevated values of any of the four enzymes indicated the presence of metastases.


Hospital and health care--what price?

Hospital and health care--what price?


Standardization.

Standardization.


Nomograms for use in determining pulmonary compliance and non-elastic resistance.


Improved design of a pulse duplicator to study the natural heart valves.


Traumatic rupture of a papillary muscle of the heart. Report of a case.


Pulmonary muscular hyperplasia. A report of functional data in three cases with a brief review of the literature.


Cardiac arrhythmias in acute myocardial infarction. I. Complete heart block and its natural history.


The prognostic value of a reduced maximum breathing capacity in tuberculosis.


Surgical treatment of severe pulmonary hypertension.


The safety of general anesthesia for bronchoscopy demonstrated by a study of arterial and venous oxygen saturation levels.


Relapses in pulmonary tuberculosis.

Relapses in pulmonary tuberculosis.


Pulmonary resection as treatment for coccidioidomycosis of the lung. Review of fifteen cases.


Spontaneous pneumothorax: treatment and mortality.


Comparative study of pacemakers.

Comparative study of pacemakers.


Paroxysmal ventricular tachycardia in non-cardiac diseases.


Roentgenogram of the month.

Roentgenogram of the month.


A report on an implantable electronic cardiac pacemaker.


Use and abuse of statistics.

Use and abuse of statistics.


Rehabilitation of the patient with a permanent pacemaker.


Allergic pulmonary aspergillosis successfully treated with inhalations of nystatin. Report of a case.


Assessing the coronary profile.

Assessing the coronary profile.


Effect of diet on blood cholesterol of the elderly.


Superficial thrombophlebitis. Observations on diagnosis and treatment.


Organic brain syndrome in the elderly.

Organic brain syndrome in the elderly.


Indications for radical mastectomy.

Indications for radical mastectomy.


The clinical use of wine in geriatrics.

The clinical use of wine in geriatrics.


Posthospital care: a challenge to the geriatric treatment team.


The role of cigarette smoking in the causation of atherosclerosis.


On the function of the kinocilia and stereocilia with special reference to the phenomenon of directional preponderance.


The middle ear in accidental deaths.

The middle ear in accidental deaths.


Myringotomy, alpha-chymotrypsin and reverse politzerization for "glue" ears.


A case of objective tinnitus.

A case of objective tinnitus.


The use of hypothermia in intra-arterial chemotherapy for head and neck cancer.


Cancer of the pharynx. A study based on 2,417 cases with special reference to radiation treatment.


Long-term results of adipose tissue in stapedioplasty in otosclerosis.


Normal values for caloric tests using electro-oculography.


Nasopharyngeal cancer in Sarawak (Borneo).


Primary tuberculosis of the nasopharynx in a Nigerian.


A comparison of measurements from the clinical caloric test with those from the test using electro-oculographic recordings.


Metastatic maxillary antrum seminoma.

Metastatic maxillary antrum seminoma.


Fibrosarcoma of tonsil.

Fibrosarcoma of tonsil.


Arteriography in management of epistaxis.


Effect of hibernation on course of infection and immune response in Citellus tridecemlineatus infected with Nippostrongylus brasiliensis.


The in vitro cultivation of Nippostrongylus brasiliensis from the late fourth stage.


Revision of the Porrorchinae (Acanthocephala: Plagiorhychidae) with descriptions of two new genera and three new species.


Effect of hypothyroidism on resistance of mice to infection with Trichinella spiralis.


Aspects of the development of Moniliformis  dubius.


Effects of the immune chicken on the endogenous stages of Eimeria tenella.


Some physiological effects of coccidiosis caused by Eimeria maxima in young chickens.


Demonstration of immunity to Fasciola hepatica in recipient mice given peritoneal exudate cells.


Anaphylactic and reagin-like antibody in rats infected with Toxocara canis larvae.


Thermal activation and inactivation of Philophthalmus gralli metacercariae.


Fasciola hepatica and Hymenolepis microstoma in the laboratory mouse.


Head louse infestation in villages of Shiraz, Iran.


Host-parasite relationships of Fasciola hepatica in the white mouse. II. Studies on acquired immunity.


The life histories of Proterometra albacauda and Proterometra septimae, spp. n. (Trematoda: Azygiidae) and a redescription of Proterometra catenaria Smith, 1934.


Increased resistance in mice to larval Ascaris suum infection induced by Nippostrongylus brasiliensis.


Comparative egg counts and histopathology in turtles infected with Spirorchis (Trematoda: Spirorchiidae).


Occurrence of metacercariae within echinostome rediae transplanted into Australorbis glabratus.


Ultrastructure of mitochondria in a cestode, Lacistorhynchus tenuis (V. Beneden, 1858).


Report of a case of Mesocestoides (Cestoda) in a child in Missouri.


Studies on phosphatase activity in trematoda.


Developmental physiology of cestodes. II. Effects of changes in host dietary carbohydrate and roughage on previously established Hymenolepis diminuta.


The effects of the mating pattern of the mouse on the formation of corpora lutea.


Pulmonary lesions associated with oxygen therapy and artificial ventilation.


Fine structure of the striated border of the intestinal cells of Ancylostoma caninum.


Case records of the Massachusetts General Hospital. Case 7-1967.


Value of genetic variants of glucose-6-phosphate dehydrogenase in tracing the origin of malignant tumors.


Visual changes after antimalarial medication.


Concerning catheter-induced infections.

Concerning catheter-induced infections.


Radiation-induced graft copolymerization of alkyl methacrylates onto polypropylene.


Stimulation of thymic regeneration in irradiated mice with the RLP factor derived from sheep spleen.


The effect of the interval between intraperitoneal administration of cystamine and exposure on the dose-reduction factor for hematopoietic stem cells.


Spectral fluence of scattered radiation in a water medium irradiated with diagnostic x-rays.


Electrophoretic mobility, size distribution and electron micrograph responses of lymphocytes to radiation.


Kinetics of aging as revealed by x-ray-dose-lethality relations in Drosophila.


X-irradiation response by TD-50 and survival time assays for a murine lymphoma.


The interaction of irradiated basic proteins with mono- and polyribonucleotides: a light-scattering investigation.


Rheumatic fever and rheumatic heart disease. A five-year study of rheumatic and non-rheumatic families.


Frequency of twinning in California. Its relationship to maternal age, parity and race.


Mycoplasma pneumoniae infections in a children's population: a five-year study.


Mycobacterial infections in Norway: a preliminary note on determining their identity and frequency.


Epidemiologic studies on gram-negative bacilli in the hospital and community.


A cardiovascular survey of American East Coast telephone workers.


Relationships between toxemia of pregnancy and essential hypertension in a total community.


Epidemiological study of Coxsackie A-21 virus infections in military recruits.


Geographic variation in the antigenic character of West Nile virus.


Prognosis for survival after stroke.

Prognosis for survival after stroke.


The use and value of lung scan in recognition of pulmonary embolism.


The renal carrier state of experimenal Leptospira pomona infections in skunks (Mephitis mephitis).


Serum cholesterol concentrations during physical training and during subsequent detraining.


Beta-glucuronidase excretion in hypertensive patients.


Hemodynamic and oxygen transport responses to exercise in hypertensive and normotensive age peers: effects of hypotensive drug treatments.


Studies on infectious mononucleosis. V. The Arneth count (preliminary observations).


Cytophilic antibody. I. Nature of the macrophage receptor.


In vitro detection of human reagins by double layer leucocyte agglutination: method and controlled blind study.


Relationship between clinical severity of disease and hemodynamic patterns in essential hypertension.


Electrophoretic mobilities of antigen-stimulated lymph node cells.


The cross-reacting antibodies of group O sera:  immunological studies and possible explanation of the observed facts.


Non-precipitating rabbit antibody to hapten: purification and properties.


Delayed hypersensitivity in the guinea-pig to a protein-hapten conjugate and its relationship to in vitro transformation of lymph node, spleen, thymus and peripheral blood lymphocytes.


Physical medicine and rehabilitation for stroke patients.


Some factors in acute renal failure.

Some factors in acute renal failure.


Chronic alcoholism--after thirty years, some second thoughts.


Alcoholism in the aged--modern concepts.


Pulse-wave changes with aging.

Pulse-wave changes with aging.


Aspiration pneumonia after cardiac arrest and resuscitation.


The rehabilitative program in pulmonary emphysema.


Electroencephalographic studies on the aging process. Psychometric correlates.


Pentylenetetrazol with nicotinic acid in the management of chronic brain syndrome.


Effects of nortriptyline on the mental and social adjustment of geriatric patients in a mental hospital.


Humanizing institutional care for the aged.


A rapid disability rating scale.

A rapid disability rating scale.


The effect of thyroxine on the movement of calcium and inorganic phosphate through the small intestine of the rat.


Comparison of an immunoassay and bioassay of insulin in sheep plasma.


A thin-layer chromatography study on the metabolism of prednisolone in the horse.


The effect of blood-borne factors on adrenal steroid synthesis in the golden hamster (Mesocricetus auratus Nehring).


Thyrocalcitonin and its role in calcium homeostasis.


Factors affecting the variation in response of mice to gonadotrophic hormones.


Unit activity in the hypothalamus, septum and preoptic area of the rat: characteristics of spontaneous activity and the effect of oestrogen.


Determination of free and conjugated oestrogens in fluid from human ovaries.


The release of bound corticosteroids from the muscle of the toad (Xenopus laevis).


Biological half-life of intravenously injected oxytocin in the circulation of the sow.


The formation of 21-deoxycortisol by human adrenal tissue.


Fibrosarcoma of larynx--its clinical features and treatment.


Lesions of the apical region of the cochlea.


Tomography of the inner ear in deaf children. Radiological demonstration of two cases with the Mondini malformation.


Naso-alveolar cysts.

Naso-alveolar cysts.


Hearing children of deaf parents.

Hearing children of deaf parents.


Dacryocystorhinostomy in children and infants.


The acuity of hearing in the Kalahari Bushmen . A pilot survey.


The problems of type C tympanoplasty.

The problems of type C tympanoplasty.


Posterior tympanotomy. Its importance in combined approach tympanoplasty.


A punch card system for processing data from stapedectomy operations.


Chondroma of naso-pharynx.

Chondroma of naso-pharynx.


Ossifying fibroma of the sphenoid.

Ossifying fibroma of the sphenoid.


Lateral extensions of nasopharyngeal fibroma.


The medical schools twenty years afterwards: impact of the extramural research support programs of the National Institutes of Health.


The interdependence of regional medical programs and continuing education.


The development of a computer-assisted instruction program in a medical center environment.


The community hospital affiliation program of the New York Medical College.


Fifty medical students: a comparison with "normals".


Learning clinical skills through the use of self-teaching films.


The use of a programmed text during a course in genetics for medical students.


Undergraduate college in relation to medical school acceptance and success.


Turnover of catecholamines in active and hibernating ground squirrels.


The accumulation of organic bases by the human platelet.


The anticonvulsant action of inhibitors of carbonic anhydrase: relation to endogenous amines in brain.


A peripheral component of centrally acting muscle relaxants: chlormezanone and mephenesin.


Liver parenchymal cell injury. IV. Pattern of incorporation of carbon and chlorine from carbon tetrachloride into chemical constituents of liver in vivo.


The pharmacology of 2,3-bis-(p-methoxyphenyl)-indole (indoxole).


The interrelationship between thallium and potassium in animals.


Insecticide inhibition and stimulation of steroid hydroxylases in rat liver.


Steric aspects of adrenergic drugs. 3. Sensitization by cocaine to isomers of sympathomimetic amines.


A possible role for tissue calcium in reserpine supersensitivity.


Selective reduction in neurogenically induced constriction by phenoxybenzamine.


The influence of calcium on the cardiotropic actions of rhodochlorin and ouabain.


The effects of sodium ion and rate of stimulation on the refractory period of isolated rabbit atrial muscle.


Effects of methylguanidine on the electrical activity of single pacemaker fibers in the sinus node of the rabbit.


The cardiopulmonary effects of a quinazoline (MJ 1988): cardiac stimulant, pulmonary vasodilator and bronchodilator.


The effect of sanitation on ascariasis in an Iranian village.


A note on the biometrics of Ascaris infection.


Uptake of propranolol by isolated guinea-pig atria.


Scarabiasis.

Scarabiasis.


A sample of the medical population of Zambia, 1965.


Rhabdite formation in planaria: the role of microtubules.


The ultrastructure of the nuclear periphery. The zonula nucleum limitans.


Three-dimensional studies of neurons in the lateral geniculate nucleus of the rat. 3. Specialized neuronal contacts in the neuropil.


The occurrence of DNA fibrils in chloroplasts of Laurencia spectabilis.


Observations on the postnatal development of neuronal structures in the lateral geniculate nucleus of the rat by electron microscopy.


Studies on the protein synthesis in the guinea pig thyroid. II. In vivo labeling of thyroglobulin with 3H-leucine.


Ultrastructure and development of iron mineralization in the radular teeth of Cryptochiton stelleri (Mollusca).


The ultrastructure of wax deposits on plant leaf surfaces. II. Cuticular pores and wax formation.


The development of the secretory granules in the rat adrenal medulla.


The occurrence of inclusions within membrane-limited structures that run longitudinally in the cells of mammalian heart muscle.


Tubular systems in Purkinje cells of the cat heart.


The morphology of arabis mosaic virus.

The morphology of arabis mosaic virus.


Multifunctional plastids in the meristematic region of potato tuber buds.


The importance of the follow up visit in the treatment of head and neck cancer.


Neurilemmoma of the pharynx. Report of two cases.


Inner ear pathology in experimental diabetes.


Non-surgical recording of auditory nerve action potentials in man.


Congenital cholesteatoma of the temporal bone. A case report.


Pathology of epistaxis.

Pathology of epistaxis.


Inter-specialty cooperation in the stabilization of cervical spine fracture/dislocation.


Regional enteritis in children: surgical aspects.


Histamine formation: histidine decarboxylase determination using carboxyl-14-C-labeled histidine.


Experience in providing a viral diagnostic laboratory compatible with medical practice.


Aneurysms of the anterior communicating artery complex.


Histiocytosis X: a clinical study.

Histiocytosis X: a clinical study.


A comparison between arterial and arterialized capillary blood in infants.


A case of compound volvulus in a Basuto.


The hazards of skin- and scuba-diving.

The hazards of skin- and scuba-diving.


Malignant melanoma--a clinico-pathological survey.


Oral contraception dropout rate.

Oral contraception dropout rate.


Vectorcardiography as an aid to the understanding and teaching of the electrocardiogram.


Methods in parapsychology.

Methods in parapsychology.


Studies of nonrandom groups.

Studies of nonrandom groups.


Analysis of protein components of tomato strains of tobacco mosaic virus.


Factors affecting the local lesion response of Nicotiana glutinosa to lettuce necrotic yellows virus.


Infective subviral particles from cell cultures infected with myxoma and fibroma viruses.


Physiology of tobacco etch virus-induced wilt of tabasco peppers.


Broadbean mottle virus in leaf tissue.

Broadbean mottle virus in leaf tissue.


The occurrence in the body of Bemisia tabaci of a factor apparently related to the phenomenon of "periodic acquisition" of tomato yellow leaf curl virus.


Electrophoretic and buoyant density variants of southern bean mosaic virus.


Induction of T antigen in HeLa cells by adenotumor extracts and differential inactivation of the T antigen inducibility and the infectivity of type 12 adenovirus.


Integration-negative (int) mutants of phage lambda.


The purification of potato leafroll virus from its vector Myzus persicae.


Hypocalcemia and defective hemostasis after massive blood transfusion. Report of a case.


The distribution of viral antigen in cells infected with tobacco mosaic virus as revealed by electron microscopy.


Correlation of histologic grading with 5-years survival rates in endometrial carcinoma.


Electron microscopy of cytoplasmic inclusion bodies in cells infected with rinderpest virus.


Serological and immunochemical studies of snail (Otala lactea) anti-A: a simple purification method.


Management of anatomic urinary incontinence by vaginal repair.


Intraepithelial carcinoma of the cervix in association with pregnancy.


Further studies on the effect of adenine in blood preservation.


A study related to the significance of hemolysins observed among aborters, nonaborters and infertility patients.


Azathioprine (Imuran) and pregnancy.

Azathioprine (Imuran) and pregnancy.


Some chemical studies on a strain of white clover mosaic virus.


Serial hormone assays in patients with uteroplacental insufficiency.


Mass lesions in the left atrium.

Mass lesions in the left atrium.


Treatment of pancreatic duct obstruction by "split" pancreaticojejunostomy.


The blood inventory control system--helping blood bank management through computerized inventory control.


Selective actions of volatile anesthetics on synaptic transmission and autorhythmicity in single identifiable neurons.


The effect of volatile anesthetic agents on neuromuscular transmission.


Effects of anesthetics on spinal cord of mammals.


The heritages of the past are the privileges of the future.


Chemical transmission and cortical arousal.


The effects of anesthetic drugs on cortical units.


The effect of inhalation anesthetics on repetitive activity generated at motor nerve endings.


Thiopental: effects on subcortical mechanisms in temporal lobe epilepsy.


Evaluation of a rebreathing tube for preventing atelectasis.


Effects of lidocaine on the central nervous system.


An anesthetic machine for small mammals.


A quantitative technique for the evaluation of peripheral neuromuscular blockade in man.


Preoperative correction of coagulation in tetralogy of Fallot.


Persistent postoperative idionodal hypotension treated with minimal bicarbonate.


External electroenterography.

External electroenterography.


Altered lymphatic dynamics caused by cancer metastases.


Exaggerated spread of epidural block.

Exaggerated spread of epidural block.


The inspiratory force measurement using the anesthesia circuit.


Fetal arrhythmia during caudal block with prilocaine.


Treatment of volvulus of the sigmoid colon and cecum.


Isolated block of musculocutaneous and perineal nerves in the management of spasticity with special reference to the use of a nerve stimulator.


Epiglottic elevator.

Epiglottic elevator.


Excision of glands in continuity for malignant melanoma. Review of end results following several techniques.


Adenoid cystic carcinoma of the breast.

Adenoid cystic carcinoma of the breast.


Prolonged anesthesia, overcurarization, and resection of the abdominal wall.


Pain mechanisms.

Pain mechanisms.


Superior sulcus tumor with 14-year survival.


Brain stem mechanisms of sleep.

Brain stem mechanisms of sleep.


Lobar staphylococcal pneumonia. An unusual variant.


The mechanisms of general anesthesia.

The mechanisms of general anesthesia.


Congenital cysts of the thymus gland.

Congenital cysts of the thymus gland.


Perspectives.

Perspectives.


The neurophysiology of anesthesia.

The neurophysiology of anesthesia.


Bile duct proliferation in atresia and related hepatic diseases. A morphological study.


Fine structure of cell contact and the synapse.


N-alkyl-alpha-cyanoacrylate monomers in surgery. Speed of polymerization and method of their application.


A combined intraluminal and extraluminal vein stripper.


A disposable endotracheal tube with self-inflating cuff.


A simplified, trouble-free transducer holder.


Intersigmoid hernia. Review of the literature and report of an additional case.


Left inguinal herniation of the cecum.

Left inguinal herniation of the cecum.


Liposclerotic mesenteritis.

Liposclerotic mesenteritis.


Duplication cyst of the duodenum.

Duplication cyst of the duodenum.


Dietary prevention of experimental shock lesions.


Functional organization of the spinal cord.


Acute, severe hemodilution with lactated Ringer's solution.


Species differences in response to cortisone in wounded animals.


Micromethods in neuropharmacology: an approach to the study of anesthetics.


Visceral arterial occlusion. Effects on portal venous flow and pressure.


Gangrene of the hand following intra-arterial injection.


Atherothrombotic embolism of lower extremities in arteriosclerosis.


Epilepsy and driving.

Epilepsy and driving.


Early diagnosis of bladder cancer.

Early diagnosis of bladder cancer.


Results of no-loop gastrectomy for duodenal ulcer.


Delayed chloroquine retinopathy.

Delayed chloroquine retinopathy.


Ingrowing toenails.

Ingrowing toenails.


An obsolete term.

An obsolete term.


Post-transfusion hepatitis.

Post-transfusion hepatitis.


Driving after temporal lobectomy for epilepsy.


Depression.

Depression.


Progressive focal sclerosis of retinal arteries: a sequel to impaction of cholesterol emboli.


Correlation of chromosome counts with histological appearances and prognosis in transitional-cell carcinoma of bladder.


Parietal cell responsiveness in duodenal ulcer.


Parietal lobe inadequacy in mental deficiency.


Bethanidine.

Bethanidine.


Medullary thyroid carcinoma and phaeochromocytoma: a familial chromaffinomatosis.


New turning-tilting bed and head-traction unit.


Dangerous patients.

Dangerous patients.


Special experience and service.

Special experience and service.


Measures against drug addiction.

Measures against drug addiction.


Mercurialism extraordinary.

Mercurialism extraordinary.


Prolonged endotracheal intubation.

Prolonged endotracheal intubation.


Mycoplasma hominis in abortion.

Mycoplasma hominis in abortion.


Unusual case of mercury poisoning.

Unusual case of mercury poisoning.


Host defences to Burkitt tumour.

Host defences to Burkitt tumour.


Self-administration of mercury by subcutaneous injection.


Pericyazine.

Pericyazine.


Calcium injection for cardiac arrest.

Calcium injection for cardiac arrest.


Bleeding peptic ulcer.

Bleeding peptic ulcer.


Tybamate.

Tybamate.


Androgens in metastatic renal adenocarcinoma.


Phenothiazines in early labour.

Phenothiazines in early labour.


Thiopentone in status epilepticus.

Thiopentone in status epilepticus.


Dependence on dextromoramide.

Dependence on dextromoramide.


Bilateral rupture of quadriceps tendons.


Hazards of cosmetic surgery.

Hazards of cosmetic surgery.


Spontaneous closure and treatment of ventricular septal defect.


Lessons of the "pink spot".

Lessons of the "pink spot".


Jarisch-Herxheimer reaction.

Jarisch-Herxheimer reaction.


Preventing pressure sores in hospital: controlled trial of a large-celled ripple mattress.


Selective thymic venography: new method for visualization of the thymus.


The Talbot fingers: a study in symphalangism.


Assessment of possible glucocorticoid activity of carbenoxolone sodium.


Motor-car driving and the heart rate.

Motor-car driving and the heart rate.


Iron and folate supplements in pregnancy.


Case of Demons-Meigs's syndrome.

Case of Demons-Meigs's syndrome.


Swimming-pool granuloma.

Swimming-pool granuloma.


Idiopathic Haemochromatosis.

Idiopathic Haemochromatosis.


Anaesthesia for dental extractions.

Anaesthesia for dental extractions.


Amines and depression.

Amines and depression.


Prognosis in breast cancer.

Prognosis in breast cancer.


Imported tropical disease.

Imported tropical disease.


Bronchial neoplasms and hormonal secretions.


Periodic paralysis complicating thyrotoxicosis in Chinese.


Influenza, respiratory syncytial virus, and pneumonia in Glasgow, 1962-5.


Studies on an epidemic of respiratory disease caused by Mycoplasma pneumoniae.


Peripheral gangrene in infancy and childhood.


Thymectomy in acute systemic lupus erythematosus and rheumatoid arthritis.


Behçet's syndrome and autoimmunity.

Behçet's syndrome and autoimmunity.


Childhood nephrosis followed by acute glomerulonephritis in adulthood.


Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease.


Topical ampicillin and wound infection in colon surgery.


Case of Reiter's disease treated with lincomycin hydrochloride.


Allopurinol.

Allopurinol.


A case of staphylococcal septicaemia with endocarditis and cerebral abscess.


Chloramphenicol.

Chloramphenicol.


Group practice nurse: an analysis and comment on six months' work.


Forged prescriptions.

Forged prescriptions.


The difficult teenager.

The difficult teenager.


Imipramine and benzhexol.

Imipramine and benzhexol.


Epidemiology.

Epidemiology.


Epilepsy and driving.

Epilepsy and driving.


Debate on the health service.

Debate on the health service.


Polio vaccine and congenital defects.

Polio vaccine and congenital defects.


Ovarian cancer at the Ontario Cancer  Foundation Clinics, 1938-1958. In Ontario, ovarian cancer causes 7% of female cancer deaths, exceeding cancer of the uterine cervix or corpus in women aged 50 years and over. For 1722 patients with ovarian cancer registered at the Ontario Cancer Foundation Clinics in 1938-1958, who received some or all of their treatment at the clinics or were untreated anywhere, the crude survival rate at five years was 28%. Survival was greatly influenced by extent of disease and by histological type; survival rates remained constant or rose slightly over successive periods although an increasing proportion of advanced cases were registered. The method of choice for initial treatment was panhysterectomy with bilateral salpingo-oophorectomy and radiotherapy. Agreement on classification by histological type and extent is urgently needed.


Thalassemia in Canadians.

Thalassemia in Canadians. Thirteen Canadians with a mild hypochromic anemia were found to have beta thalassemia trait. The families of these individuals had resided in Canada for two to five generations and, where known, had not emigrated from areas with a high incidence for the thalassemia gene. A Negro family with abnormal erythrocyte morphology was suspected to be carrying the thalassemia gene although the hemoglobin A(2) concentration was normal and abnormal minor components were not detected. Thalassemia trait has been detected in practically every ethnic group, and its sporadic occurrence among Canadians without Mediterranean ancestry can be expected.


Atypical mycobacteria in the Niagara Peninsula. From 1960 to 1965, 44,629 cultures were performed on persons attending chest clinics in the Niagara Peninsula.Tubercle bacilli were cultured from 965 biological specimens (2.16%) and atypical mycobacteria from 281 specimens (0.62%).Twelve subjects had more than one variety of atypical mycobacterium in their secretions, suggesting the occurrence of mutation. The administration of antituberculous drugs may have contributed to the emergence of atypical mycobacteria in some instances, but 41 patients had never received antituberculous drugs.Of 113 persons from whom atypical mycobacteria were cultured only two had lung infection primarily due to the atypical mycobacterium isolated.


The effects of hypnotherapy on homosexuality. Fifteen homosexuals were treated with hypnosis. The patients were selected from a general psychiatric practice and had a long history of confirmed homosexual behaviour and showed no evidence of organic or psychotic illness. The type of hypnotic induction attempted in all cases is described. In those where a satisfactory depth of hypnotic trance was achieved a change in sexual orientation was suggested to the patient.Before therapy, each patient was assessed using the Kinsey scale. Results were evaluated in terms of the patient's subsequent behaviour and his subjective feelings. Of the 15 patients, three showed no improvement, four showed a mild improvement and eight showed a marked improvement. There was a significant correlation between the depth of hypnosis achieved and the therapeutic outcome. Those patients who reached a deep level of hypnotic trance were most likely to show a marked improvement. There were no significant correlations with other factors such as degree of homosexuality as measured on the Kinsey scale and the patient's marital status.Treatment of homosexuals with hypnosis may produce more satisfactory results than those obtainable by other means. The best results are likely to be achieved in patients who are good hypnotic subjects.


Clinical conference on cancer of the ovary.


Chromosomal aberrations following radioiodine therapy.


Gilbert's disease and the bilirubin tolerance test.


Lift those feet.

Lift those feet.


Pulmonary emphysema: pathology and pathogenesis.


Respiratory acidosis: diagnosis and management.


Emphysema and chronic bronchitis: clinical manifestations and their physiologic significance.


Acute respiratory failure. Experiences of a respiratory care unit.


Rehabiliation of patients with chronic obstructive lung disease.


Prognosis in chronic obstructive pulmonary disease.


Evaluation of surgical risk in patients with chronic obstructive lung disease and other respiratory handicaps.


Pulmonary diffusion and alveolar-capillary block.


Diffuse interstitial pulmonary fibrosis.


Sarcoidosis: clinical features and management.


Recognition and current management of the systemic mycoses.


Atypical mycobacterial infections; pathogenesis, clinical manifestations, and treatment.


Suppurative lung diseases.

Suppurative lung diseases.


Clinical and intellectual causes of defective statistics for the prognosis and treatment of lung cancer.


Comparison of thyroxine secretion rate of docile and flighty lines of fowls.


Alcoholic lung disease--an hypothesis.

Alcoholic lung disease--an hypothesis.


Pheochromocytoma masquerading as overwhelming infection.


The possible role of hemoconcentration in the etiology of myocardial infarction.


Effects of posture and exertion on levels of serum cholesterol and lactic acid.


Apexcardiography: use in coronary heart disease and reproducibility.


Radiologic evaluation of pulmonary vasculature in infants with heart disease.


Histogenesis of experimentally induced myositis ossificans in the heart.


Deceleration of the heart by alternating current. A new experimental technique.


Electrocardiographic changes and oxygen consumption in acute salt depletion.


Certain immunologic substances in the serum of patients with myocardial infarction and other cardiovascular diseases.


Effect of propranolol, a beta-adrenergic antagonist, on blood flow in the coronary and other vascular fields.


Cardiac manifestations of hyperparathyroidism, with presentation of a previously unreported arrhythmia.


Clinical pathologic conference (coronary disease).


Atrioventricular dissociation with S-A interference (ventricular capture), A-V interference (atrial capture), and reciprocating beating. "Incomplete" retrograde unidirectional A-V block.


Reappraisal of digitalis. VI. Chemistry of commonly used cardiac glycosides.


Lumbar sympathectomy.

Lumbar sympathectomy.


Primary prevention of coronary heart disease by diet.


Aneurysmal degeneration of arterial homografts.


The heart in hyperthyroidism.

The heart in hyperthyroidism.


The education of nurses.

The education of nurses.


Inner ear pathology in acoustic neurinoma.


Endolymphatic duct pressure produces cochlear damage.


Inner ear pathology of congenital deafness.


Hydrogen peroxide and irradiation of tumors.


Congenital malformations of the stapes footplate.


Streptomycin in Ménière's disease. Long-term follow-up.


Subluxation and depression of stapes footplate. Comparison with fat graft and wire stapedectomy.


The fixed malleus head. A report of 35 cases.


Stapedectomy for otosclerosis. Some causes of failure.


Vestibulospinal reflexes. X. Theoretical and clinical aspects of the stepping test.


Hibernoma of the neck.

Hibernoma of the neck.


Osteoma of the tongue.

Osteoma of the tongue.


Intravenous lidocaine with general anesthesia for endoscopy.


Prolonged nasotracheal intubation in infants and children.


Microlaryngoscopy with a new laryngoscope.


Rhinoscleroma. A case report.

Rhinoscleroma. A case report.


Watermelon seed in the tracheobronchial tree in Iran.


The influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney.


Coated charcoal assay of erythrocyte vitamin B 12 levels.


Regulation of fetal and adult hemoglobin formation in patients with sickle cell disease transfused to normal hematocrits.


Protease content and fibrinolytic activity of human leukocytes.


The effect of plethora on growth and differentiation of normal hemopoietic colony-forming cells transplanted in mice of genotype W/Wv.


Leukemia or lymphoma occurring subsequent to an autoimmune disease.


Studies of lymphocyte kinetics in man.

Studies of lymphocyte kinetics in man.


The effects of allografts of thymic epithelial reticular cells on the lymphoid tissues of neonatally thymectomized mice.


Evidence for the origin of plasma cells from adventitial cells. I. Sensitized subcutaneous connective tissue examined by light microscopy.


Composition and structure of cytoplasmic globules in leukemic lymphocytes.


Detection of glucose-6-phosphate dehydrogenase deficient heterozygotes.


Diagnosis of osteoporosis in childhood.

Diagnosis of osteoporosis in childhood.


Multiple myeloma presenting as pulsating sternal tumours.


An automatic gamma-ray exposure device.

An automatic gamma-ray exposure device.


Some observations on the course taken by cardiac catheters in children.


The oxygen effect for acute and protracted radiation exposures measured with seedlings of Vicia faba.


Modified guide wire for percutaneous catheterisation of kinked or severely atheromatous arteries.


Instrumental and technical notes. An apparatus for dispensing radioactive solutions.


A self-retaining injector for sinography.


Dystrophia myotonica--a radiological survey.


Angiographic appearances of bilharzial mass of the colon.


pH dependence of the oxyhemoglobin dissociation curve at high oxygen tension.


Medullary surface chemoreceptors and regulation of respiration in the cat.


Differential pulmonary diffusion capacity in normal dogs.


Quantitation of collagen in the wall of the human urinary bladder.


Peritoneal dialysis during hemorrhagic shock.


Renal servocontrol of arterial blood pressure.


Cardiovascular effects of acclimatization to heat and cold in chickens.


Effect of parathyroid extract on magnesium excretion in man.


Role of plasma proteins in the effect of polybasic polymers on red blood cell charge.


Effect of changes in Pa-CO2 and Pa-O2 on cardiac performance in conscious dogs.


A simple inexpensive heartbeat monitor.

A simple inexpensive heartbeat monitor.


Electrical impedance plethysmography: a critical analysis.


A rapid blood sampler.

A rapid blood sampler.


A simple blood pressure stabilizer: its use as a noradrenaline blood pressure regulator.


Sympathico-adrenomedullary activity in dogs during acute heat exposure.


A clamp for precisely controlled progressive constriction of the pulmonary artery.


Electroejaculation and evaluation of semen from the albino rat.


Muscle balance with electrical-to-mechanical loading transducer.


A continuous-flow calorimeter for measuring total heat production by skeletal muscle.


Intragastric balloon without gastric surgery for the rat.


An air-driven micropipette sharpener.

An air-driven micropipette sharpener.


An electronic analogue of carbon dioxide distribution in the body.


Shivering and heat production in men exposed to intense cold.


Rate of loss of acclimatization in summer and winter.


Experimental determination of coefficient of heat exchanges by convection of human body.


Cold exposure of farm and laboratory workers.


Heat acclimatization by controlled hyperthermia in hot-dry and hot-wet climates.


Metabolic stress of endurance swimming in the laboratory rat.


Effect of acclimatization on the sweat rate-rectal temperature relationship.


Physical performance of women following heat-exercise hypohydration.


Hemodynamic response to work with different muscle groups, sitting and supine.


Interaction of physiological mechanisms during exercise.


Significance of the relationship between lung recoil and maximum expiratory flow.


Central temperature regulation in the spinal man.


Acclimatization of highly trained men to work in severe heat.


Ultrasonic examination of teeth.

Ultrasonic examination of teeth.


Further advances in ultrasonic diagnosis.


Long-term follow-up study in idiopathic steatorrhea.


Retinal reattachmnet without release of subretinal fluid.


Use of teflon in retinal detachment surgery.


Management of traumatic hyphema.

Management of traumatic hyphema.


Prognosis in stripping of Descemet's membrane in cataract extraction.


Anatomic considerations in the plastic construction of a palpebral fold in the full upper eyelid.


The volume of blood in the intact living eye.


Macular illumination test in central serous retinopathy.


Enzymatic zonulolysis and postoperative ocular hypertension.


Simple dacryops.

Simple dacryops.


Massive intrafacial foreign body.

Massive intrafacial foreign body.


Sterile disposable cautery.

Sterile disposable cautery.


Suturing forceps for corneal and cataract surgery.


Anterior-chamber knife-needle.

Anterior-chamber knife-needle.


Double-end plastic retractor for round-pupil cryoextraction of cataract.


Bilateral symmetrical sectoral pigmentary lesions of retina.


Ocular changes in myotonic dystrophy.

Ocular changes in myotonic dystrophy.


Glaucoma masque.

Glaucoma masque.


Pupillary response to momentary light stimulation to eyes unequally adapted to light.


The tonic pupil: a re-evaluation.

The tonic pupil: a re-evaluation.


A new operating microscope for ocular surgery.


Desferrioxamine B in ophthalmology. Applications and therapeutic possibilities.


The maintenance of excellence.

The maintenance of excellence.


Skin temperature and blood flow changes in occlusive arterial disease under physical and pharmacologic therapy.


Hereditary telangiectasia and pulmonary fistula. Case of large right-to-left shunt surgically corrected.


Functional, hemodynamic, and anatomic changes in isolated perfused dog lungs: the importance of perfusate characteristics.


Acute parenchymal dysfunction with acute anuria induced by retrograde pyelography.


Studies of the changes in growth and DNA synthesis in the rat kidney during experimentally induced renal hypertrophy.


The Adelaide ventilation guide.

The Adelaide ventilation guide.


Electroencephalographic activity during voluntarily controlled alveolar hyperventilation.


Recording and analysis of clinical data.


Anaphylaxis to suxamethonium. A case report.


Accidental injection of thialbarbitone into an anomalous radial artery.


Pleural effusion complicating thiopentone administration. A case report.


Ectopic pregnancy: a statistical review of 360 cases. In a statistical analysis of 360 cases of ectopic pregnancy admitted to the Montreal General Hospital over a 20-year period ending December 1964, ectopic gestation occurred once in every 83 admissions to the gynecological service. This incidence has remained constant over the years. Only one out of four patients had had more than one child and 30% of the patients had absolute or relative infertility. Diagnosis was delayed or not made in 58 patients. There was evidence that neurogenic factors play a role in the etiology of ectopic gestation. Ten per cent of the patients had had a previous operation for the same condition. Symptomatology is variable and the possibility of ectopic pregnancy must never be overlooked in a woman of child-bearing age. Once the diagnosis is made the treatment is early operation. The morbidity rate in this series was 28% and there was one death.


The relationship of diabetes mellitus and body weight to osteoporosis in elderly females. Assessment of roentgenographic measurements of cortical bone of the radius in 196 elderly females, including 63 diabetics, revealed that: (1) in the non-diabetic group there was a significant loss of cortical bone relative to the number of years after the menopause and to body weight; (2) although there was a significant loss of cortical bone relative to years postmenopausal in a group of diabetic patients the cortex in the diabetic group was better preserved than in those non-diabetic controls in whom no vertebral compressions were diagnosed in the roentgenograms; no correlation between bone loss and body weight was found among the diabetics; (3) the thinnest cortical bone and the lowest average body weight was found in the 34 non-diabetics with vertebral compression deformities. It thus appears that involutional osteoporosis will be less prevalent among old women suffering from diabetes mellitus than in comparable non-diabetic subjects, and more prevalent among non-diabetics of low body weight than in old women who are obese or of normal weight.


The prognostic significance of circulating tumour cells: a five-year follow-up study of patients with cancer of the breast. One hundred and sixteen patients with proved cancer of the breast were followed up for five years to detect circulating tumour cells. Such cells were found in 61 patients, but, irrespective of the stage of the disease, the five-year survival rate in these was not significantly different from those in whom no tumour cells were found. The higher incidence of patients without circulating tumour cells in Stage I was not sufficient to influence the survival rate of the whole group. While the validity of the identification of these cells is questionable, the results of this study indicate that the presence or absence of tumour cells in the blood is of no prognostic significance.


Three years' experience with implanted pacemakers. At the University Hospital, Saskatoon, over the last three years, pacemakers have been inserted in 40 patients with complete or incomplete heart block. Fourteen of the patients were females and 26 were males. The average age was 65 years; 12 were over 80 years of age, and the youngest patient was 8 years of age. In none was the heart block due to operation. Thirty-three patients are still alive and well. There have been seven deaths three early and four late. One patient died because of a "runaway" pacemaker, and two as a result of infection persisting around the pacemaker. Twenty-nine Medtronic pacemakers were used and 14 Atricor pacemakers; currently we favour the latter instrument.


Initial experience with the permanent implantable transvenous pacemaker: a report of 33 patients. Thirty-three patients with heart block were treated by implantation of a permanent transvenous pacemaker. There were no deaths and few complications even though 25 of these patients were over 70 years of age. Follow-up examinations, including electrocardiograms, were done in all patients.The technique of the operation is discussed and the importance of performing it under fluoroscopic guidance in a proper surgical operating suite is emphasized. This arrangement may require the use of a portable image intensifier.This simple, effective procedure can be performed under local anesthesia and with safety, even in the elderly, frail or debilitated patient. Currently it is the authors' method of choice in the treatment of heart block; thoracotomy is now obsolete unless a synchronous pacemaker is needed or a permanent transvenous pacer cannot be inserted.


Endocrine syndromes associated with non-endocrine tumours.


The inspissated stool syndrome: an unusual mode of presentation of cystic fibrosis beyond the newborn period.


Chromosome polyploidization in human leukocyte cultures treated with streptonigrin and cyclophosphamide.


Palliative urinary diversion in patients with advanced carcinoma of the cervix.


Series elasticity in heart muscle. Its relation to contractile element velocity and proposed muscle models.


Determination of regional cerebral blood flow by inhalation of 133-Xenon.


Positive and negative factors in the therapeutic community.


Responses to drug-induced myocardial necrosis in rats with various degrees of arteriosclerosis.


Pericardial pressure during transverse accleration in dogs without thoracotomy.


Trends in admissions and resident population of a state hospital.


Microelectrode studies on retrograde concealment of multiple premature ventricular responses.


Use of psychodrama with hospitalized schizophrenic patients.


Clinical neuropathological conference.

Clinical neuropathological conference.


Developmental analysis of EEG abnormalities in juvenile delinquents.


IUPAC-IUB commission on biochemical nomenclature rules for naming synthetic modifications of natural peptides tentative rules.


Inactivation of rabbit muscle adenosine triphosphate-adenosine 5'-phosphate phosphotransferase by alkylation of methionine residues.


Spectral studies on the catalytic mechanism and activation of Pseudomonas tryptophan oxygenase (tryptophan pyrrolase).


Location of the heme moiety of cytochrome c by solvent perturbation.


Pteridine biosynthesis in the butterfly Colias eurytheme.


Adenylate deaminase. II. Purification and some regulatory properties of the enzyme from calf brain.


Studies on the equilibria and kinetics of the reactions of peroxidase with ligands. II. The reaction of ferroperoxidase with oxygen.


Treatment of defective spermatogenesis with human gonadotropins.


Studies on ribonucleic acid synthesis in tadpole liver during metamorphosis induced by thyroxine. I. Relation of synthesis of ribonucleic acid and of carbamyl phosphate synthetase.


Studies on the role of ribosomes in the regulation of protein synthesis in hypophysectomized and thyroidectomized rats.


Metabolism of taurolithocholic acid in the hamster.


The varicocele as related to fertility.

The varicocele as related to fertility.


Protein synthesis in brain slices. Effects of electrical stimulation and acidic amino acids.


The volume of the semen. A study of 3544 childless men.


An exonuclease induced by bacteriophage lambda. I. Preparation of the crystalline enzyme.


An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction.


Daily immunoassay of luteinizing hormone excretion in patients receiving clomiphene citrate.


Subcellular localization and properties of 5'-nucleotidase in the rat liver.


Tubal plastic surgery.

Tubal plastic surgery.


Binding of human serum high density lipoprotein apoprotein with aqueous dispersions of phospholipids.


The role of oxygen in the photoexcited luminescence of bacterial luciferase.


Studies on the removal of endogenous messenger ribonucleic acid activity from rat liver microsomes. Effect of removal on polyuridylic acid-directed incorporation of phenylalanine.


Adenine aminohydrolase. An investigation of specificity.


Melilotate hydroxylase. Purification of the enzyme and the nature of the prosthetic group.


Studies on the transfer of incomplete polypeptide chains across rat liver microsomal membranes in vitro.


The effect of ligand binding on the optical rotatory dispersion of myoglobin, hemoglobin, and isolated hemoglobin subunits.


Function of carnitine in the fatty acid oxidase-deficient insect flight muscle.


Subacute necrotizing encephalomyelopathy of infancy and childhood. Subacute necrotizing encephalomyelopathy appears to be a distinct pathological entity occurring in infancy and childhood. The neurological manifestations are diverse but the course is one of progressive deterioration. The aetiology is not known and no treatment is available. Histologically the lesion is characterized by multiple areas of necrosis and is remarkable because of a lack of glial or small cell reaction. There is a predilection for the brain-stem but the entire neuraxis may be involved. The mammillary bodies are generally spared. Capillary proliferation and status spongiosus are seen either separately or more commonly in combination. Areas may be found in which no neural tissue is spared or a nucleus may selectively be involved with sparing of adjacent white matter, or occasionally only white matter is involved. In this account the twenty-first, twenty-second and twenty-third cases, one of which had a lesion in the mammillary body, are reported. Possible aetiological mechanisms are discussed.


Idiopathic anterior hypopituitarism in one of monozygous twins.


A comparative study on the virulence of Mycoplasma arthritidis and "Mycoplasma hominis, type 2" strains in rats.


Distribution of radioactivity in body fat and organs of rats treated with labeled quinestrol, ethynylestradiol or 17 beta-estradiol.


Decrease in numbers of mouse spleen nodules with time post-irradiation.


Effects of acutely induced ischemic heart failure on myocardial high energy phosphate stores.


Odontogenic hamartomas in an inbred strain of mouse (STR-1N).


Agglutination of H-viruses with various types of red blood cells.


Comparative localizing response of inflammatory and irradiated tissues to injected protein.


Rapid production of interferon in bovine leucocyte cultures.


Effect of cocaine on vagal escape in the open-chest dog.


Rubella virus neutralization by plaque reduction.


Metabolic depression in animals exposed to air after living in a he-O2 environment.


The multiple nature of crystalline egg-white lysozyme.


Effect of chronic lead intoxication on in vivo I-131 uptake by the rat thyroid.


Water-food interrelationships in rats fed chemically defined liquid diets.


Cardiovascular changes in neonatal swine.


Effect of acetoacetate and beta-hydroxybutyrate on vitamin B 12 in rats.


Renal excretion of some isomeric hexoses in the dog.


Reduction of methemoglobin in human adult and cord blood erythrocytes incubated with glucose or inosine.


The "free" and "buried" tryptophan and tyrosine residues of human plasma alpha 1-acid glycoprotein.


Inhibitory effect of chlorothiazide in vitro on glucose metabolism of adipose tissue.


Brain maturation in the neonatal rat after varied light cycles.


Rheumatoid factor and immuno-conglutinin responses following various vaccinations.


Influence of protein synthesis inhibitors on circulatory dynamics.


Effects of androgens on concentrations of LH and FSH in the male rat pituitary.


Imidazole lactic acid--a component of normal human urine.


Ethanolamine metabolism in the rat.

Ethanolamine metabolism in the rat.


Composition of plasma triglyceride fatty acids and free fatty acids in hypothalamic obese mice.


Effect of 2-mercaptoethanol on rabbit pancreas isoantibodies.


Febrile responses of rabbits to bacterial endotoxin following incubation in homologous serum and plasma.


Comparison of the effect of hypothalamic and pituitary implants of estrogen and testosterone on reproductive system and adrenal of female rats.


Role of PMN-leukocyte lysosomes in tissue injury, inflammation and hypersensitivity. V. Partial suppresssion in leukopenic rabbits of vascular hyper-permeability due to thermal injury.


Biological properties of freeze-dried attenuated shigella vaccines.


Influence of chelation on gold metabolism in rats.


Metabolic effects of isoproterenol and propranolol in normal subjects before, during and after triiodothyronine-induced hypermetabolism.


Effects of epinephrine and acetylcholine on hypothalamic content of prolactin inhibiting factor.


Selective suppression of penicillin hypersensitivity by certain phenoxy propanediols.


Relationship between maximum bicarbonate and maximum acid outputs in the dog.


Effect of insulin on blood glucose and corticosterone levels in sodium fluoroacetate induced diabetes.


Effect of hypophysectomy on concentration of intrinsic factor in rat gastric mucosa.


Differential mortality of male and female germfree C3H mice introduced into a conventional colony.


Subcellular distribution of histamine in human leucocytes.


A study of passive immunization against a transplanted G+ leukemia with specific antiserum.


Short term tissue distribution of several radionuclides useful in bone scanning.


Interferon and murine leukemia. I. Inhibitory effect of interferon preparations on development of friend leukemia in mice.


Influence of glutamine on multiplication and cytopathic effect of respiratory syncytial virus.


Preliminary observations on reversal of hypovolemia with intravenous fat emulsion.


Interferon and murine leukemia. II. Factors related to the inhibitory effect of interferon preparations on development of Friend leukemia in mice.


Migration of cells to the thymus demonstrated by parabiosis.


High definition versus standard television in televised fluoroscopy.


Glutathione reductase in red blood cells: variant associated with gout. A variant of red cell gluta thione reductase, characterized by greater electrophoretic mobility, in creased enzyme activity per unit of hemoglobin, and an autosomal mode of inheritance, has been found in Negro populations. There appears to be an association of this variant with primary gout.


Acute cholecystitis. An analysis of current treatment.


Genetics of mitochondria.

Genetics of mitochondria.


Anterior lumbar fusion. A technique combining intervertebral and intravertebral body fixation.


A survey to trace previously unknown diabetes mellitus. Results from part of the health survey in the county of Värmland.


Plasmalogens in human plasma during pregnancy. A study of healthy non-pregnant and pregnant women.


Individual plasma phospholipids in women. A comparison of menstruating and menopausal 48-year-old women.


Recent developments in the early diagnosis of hyperparathyroidism.


A gel filtration method for the determination of protein in normal urine with some observations on normal renal protein excretion.


Cholesterol, phospholipids, and triglycerides in plasma in 50-year-old women. Influence of menopause, body-weight, skinfold thickness, weight-gain, and diet in a random population sample.


The myocardial metabolism in essential hypercholesterolemia. Arterio-venous differences of oxygen, glucose, lactate, pyruvate, free fatty acids and amino acids.


Gout and the pathogenesis of its attacks.


Measurement of blood flow through human abdominal subcutaneous fat tissue by local injection of radioactive xenon. Preliminary report.


Bendroflumethiazid and sweat electrolytes.


Polycythaemia and nephropathias in diabetic and hypertensive patients.


Liver-muscle enzyme activities in the serum of alcoholics on a diet poor in carbohydrates.


The tubular transport of glucose as a measure of parathyroid function.


Arterio-hepatic venous differences of free fatty acids and amino acids. Studies in patients with diabetes or essential hypercholesterolemia, and in healthy individuals.


A case of chronic poisoning with potassium cyanide?


Use of chloroquine phosphate--a new treatment for spontaneous leg cramps.


Some instrumental and methodological modifications of the technique for percutaneous renal biopsy.


Human lymphocyte migration as a parameter of hypersensitivity.


A clinical technique using Hg197 for determining the blood-cerebrospinal fluid barrier: a preliminary report.


The postaccident anxiety syndrome: psychosocial aspects.


On the need for interprofessional collaboration: psychiatry and architecture.


Perphenazine therapy among outpatients.

Perphenazine therapy among outpatients.


Kleine-Levin syndrome: report of a case.


Diagnosis and management of depressant drug dependence.


An analysis of suicide at a training center.


Automation of behavioral observations on hospitalized psychiatric patients.


Visual imagery and cognitive organization.


Postgraduate education in psychiatry for the nonpsychiatric physician: recruitment.


Studies of the therapist's role in the treatment of the schizophrenic patient.


Perceptual disorders in schizophrenia.

Perceptual disorders in schizophrenia.


Depression in acute schizophrenic psychosis.


A hydraulic lifting trolley for a high-pressure oxygen chamber.


One year after discharge: community adjustment of schizophrenic patients.


Spectrophotometric measurements of serum nickel.


Rapid fluorometric assay for plasma warfarin.


Distribution patterns of uric acid in coronary artery disease.


Calcium determinations in kinetic studies. I. A new method for low urinary calcium concentrations.


A micromethod for the determination of ferroxidase (ceruloplasmin) in human serums.


Hyperfibrinogenemia in schizophrenia.

Hyperfibrinogenemia in schizophrenia.


A source of error in an autoanalyzer determination of serum iron.


A simplified method for the analysis of ultracentrifuge film records of low-density lipoproteins of human serum.


The amount of bone in the metacarpal and the phalanx according to age and sex.


Symposium on brain tumour localisation. (1). The viewpoint of the radiotherapist.


An analysis of the progression and development of metastases in patients receiving x-radiation in hyperbaric oxygen.


Bone metastases in carcinoma of the nasopharynx.


Lymphography with supplementary tomographic examination in the pre-operative analysis of melanosarcoma.


Failure of metastatic nodes to fill during lymphography.


Bronchography with hytrast.

Bronchography with hytrast.


Who's teaching the diabetic?

Who's teaching the diabetic?


Maternal carbohydrate disorder and congenital malformations.


Evaluation of the relative pathogenic roles of diabetes and serum cholesterol levels in the development of cardiovascular lesions in rats.


Triglyceride metabolism in the alloxan-diabetic rat.


Progesterone in ovarian venous plasma and corpora lutea of the pig.


An estrogen study in the feminized dog with testicular neoplasia.


Changes in neurohypophysial proteins induced by dehydration and ingestion of saline.


Increased release of amino acids from rat thymus after cortisol administration.


Altered metabolism of DNA in rat thymus, and early response to cortisol.


Studies of the so-called virilizing effects of steroids in female rat fetuses.


Effect of estradiol benzoate on lipid metabolism in the rat.


Stability of thyrotropin in the rat pituitary gland after death.


Further studies on the purification of human postmenopausal urinary luteinizing hormone.


In vivo release of follicle-stimulating hormone following administration of hypothalamic extracts in normal, castrated, and castrated testosterone-treated rats.


Isolation of internally labeled rat prolactin by preparative disc electrophoresis.


Androgen inhibition of mammary gland differentiation in vitro.


Metabolism of 99mpertechnetate by the thyroid gland of the rat.


Effect of phenobarbital administration on the in vitro hydroxylation of cortisol and on over-all substrate and product metabolism in the guinea pig and rat.


Effect of estrogen on cycloleucine-14C and putrescine-3H uptake by the rat uterus.


Enhanced response to thyrotropin given to rats by infusion rather than injection.


Chronic thyroiditis in Buffalo rats with carbon tetrachloride-induced cirrhosis.


Potassium influx into rat erythrocytes: lack of effect of some adrenal substances, especially aldosterone, upon it.


Recovery of added gonadotrophins from human male urine following extraction by tannic acid.


Randomness of platelet adhesiveness with respect to their ATP, O2 consumption, and size.


Hemodynamic effects of peripheral vasoconstriction in normal and thyrotoxic subjects.


Direct and indirect vascular effects of cyclopropane and halothane in the dog forelimb.


Hemodynamic and metabolic effects of beta-adrenergic blockade in exercising dogs.


Cardiovascular responses to carbon dioxide before and after beta-adrenergic blockade.


Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs.


Brain CO2 buffering capacity in respiratory acidosis and alkalosis.


Respiratory mechanics and pulmonary diffusing capacity with lower body negative pressure.


Tissue oxygenation during hemorrhage in dogs breathing 1 and 3 atmospheres of oxygen.


Mathematical analysis and digital simulation of the respiratory control system.


Effect of O2 in high concentration on lung N2 clearance curve in patients with chronic bronchitis.


Respiration of dehydrating men undergoing heat stress.


Sweat inhibition by cutaneous cooling in normal sympathectomized and paraplegic man.


Factors affecting transthoracic impedance signals used to measure breathing.


Metabolic reactions to work in the desert.


Plasma enzymes in relation to aldosterone administration and heat acclimatization in rats.


Effects of drugs on heat acclimatization by controlled hyperthermia.


Local xenon 133 clearance from the quadriceps muscle during exercise in man.


Variations in olfactory sensitivity to exaltolide during the menstrual cycle.


Taste localization on the tongue, palate, and pharynx of normal man.


Responses of dogs to hyperoxic-, pentylenetetrazol-, and electroshock-induced convulsions.


Erythrocyte velocity measurement in microvessels by a two-slit photometric method.


A multiple, continuously variable infusion apparatus for small animals.


A flexible nonmetallic common left coronary arterial cannula.


Blood sampling by a chronic artificial external arteriovenous shunt in dogs.


Catheter-tip manometer for measuring blood pressure during g changes.


Miniature Peltier effect heat exchanger for extracorporeal circulation.


"In" vivo method for calibrating electromagnetic flowmeter probes.


Polygraph measurements of restrained rodents.


Lung washings in living dogs: surface activity in sedimentary fraction.


A versatile system for measuring oxygen consumption in man.


Renal function in unanesthetized normal and diabetes insipidus rats.


Design of body plethysmograph for use in field studies.


Variability of plethysmographic measurements of airways resistance in man.


The relationship between social class, average grade in college, medical college admission test scores, and academic achievement of students in a medical school.


Back-up facilities for multidiscipline laboratories.


Some applications of behavioral principles to clinical speech problems.


Auditory discrimination and articulation.


Audiologic evaluation of acoustic neurinomas.


Hypernasality as the presenting symptom of myasthenia gravis.


Audiological report of a patient with left hemispherectomy.


Differential diagnosis between aphasic and schizophrenic language in children.


Middle ear reflex measurements in pseudohypacusis.


Development of language behavior in an autistic child.


Case selection.

Case selection.


Some suggestions for more effective therapy for tongue thrust.


An approach to the correction of the defective /r/.


Use of television to study articulatory problems.


Intertest variability and the air-bone gap.


Use of 4-hydroxybutyrate to facilitate endoscopy.


The histological response to intracordal injection of teflon paste.


Pleomorphic granulosa-cell tumor. A borderline case resembling gynandroblastoma.


Twisted parovarian cysts.

Twisted parovarian cysts.


Stromal edometriosis or endometrial sarcoma.


Selection of patients for the intrauterine contraceptive device.


Incidence of postpartum sterilization.

Incidence of postpartum sterilization.


Rapid method for fetal heart rate determination.


Planned ovulation: clomiphene citrate to regulate cycles in patients using the rhythm method.


Pregnancy associated with giant hemangiomata, thrombocytopenia, and fibrinogenopenia (Kasabach-Merritt syndrome). Report of a case.


Premature separation of the normally implanted placenta. Six deaths due to gross bilateral cortical necrosis of the kidneys.


Lymphography as a diagnostic aid in female genital malignancy.


Intrapartum diagnosis of conjoined twins. Report of a case.


Gonadoblastoma (gonocytoma 3). Report of a case.


Intrauterine contraceptive devices: a comparison between their use in indigent and private patients. Use of intrauterine contraception for an aggregate 8291 months in a group of 706 private patients (mean age 27.5 years, mean number of pregnancies 2.75, 9 nulligravidas) was analyzed and compared briefly with use in a group of 623 women from  a lower socioeconomic level.  Considering private patients only, 195 (27.6%) had intermenstrual bleeding after IUD insertion and 27 (3.8%) experienced an increase in the amount or duration of menstrual flow.  All women had cramping after insertion of the Lippes loop (or Permaspiral in 2 patients); 43 (6.1%) expelled the device.  Infection developed in 9 (1.3%), and perforation of the uterus during insertion of the loop occurred in 2 patients.  The pregnancy rate for all users was 2.6 pregnancies per 100 years of use.  Termination of intrauterine contraception in 216 (30.6%) was because of intermenstrual bleeding (89 women), increased menstrual flow (7), cramping (19), infection (8), spontaneous ejection (22), a sterilizing operation on either spouse (8),  pregnancy when IUD inserted (2), pregnancy desired (37), and other personal reasons (6).  The IUD continued to be acceptable to 535 (75.8%, including those sterilized or desiring pregnancy) of 706 upper and middle class women an aggregate of 6655 months of use.  Private patients compared to clinic ones had a lower incidence of irregular bleeding (195 of 706 vs. 391 of 623), but more of them discontinued intrauterine contraception because of irregular or excessive bleeding (96 or 13.6% of private  patients vs. 28 or 4.5% of clinic patients).  The infection rate, total expulsion rate, and final rate for discontinuation due to expulsion were lower for private vs.  clinic patients (1.3% vs. 8%, 6.1% vs. 15%, and 3% vs.  5.7%, respectively).  It was found that the main advantage of the IUD, constant unburdensome protection against pregnancy, was important to both groups and that couples of any social class could effectively use intrauterine contraception.  Differences in use are due to lesser dependence on the IUD among upper strata women, who can use other contraceptive methods successfully.


Pelvic actinomycosis in the presence of an endocervical contraceptive device. Report of a case.


The fetus and the placenta as a source of insulin during pregnancy.


Oral contraceptives and intravenous glucose tolerance. I. Data noted early in treatment. The effect of oral contraceptives (OCs) on intravenous glucose tolerance tests (iv GGT) to see if the results in a "pseudopregnancy state" parallel those of actual pregnancy was evaluated.  65 women (41 nondiabetic; 24 diabetes suspects) took Enovid (5 mg norethynodrel with .075 mg mestranol) for 2-3 months.  12 women (7 nondiabetic; 5 diabetes suspects) took Ovulen (1 mg ethhynodiol diacetate and .1 mg mestranol) and 14 women (7 nondiabetic; 7 diabetes) with intrauterine devices (IUD) served as controls.  All subjects had the iv GTT before and after treatment.  The GTT was expressed as K, the % fall/min of the blood glucose level from 10-60 min after injection of 25 gm glucose.  Enovid caused a significant k decline (p .005) but no change in fasting blood sugar levels.  No women  in the Ovulen or IUD group had abnormal k values.  6 women with previosly normal k values developed abnormally low values while taking Enovid.  2 of these were in the diabetes suspect group.  Diabetes suspects using OCs appeared to show a greater loss in GT than nondiabetic subjects.  No correlation was found between carbohydrate metabolism during pregnancy and that of the "pseudopregnancy state" of progestin-estrogen administration.  The possible mechanisms responsible for these changes, in particular the role of estrogen, were discussed.


Oral contraceptives and intravenous glucose tolerance. II. Long-term effect.


Pseudosarcoma of the endometrium.

Pseudosarcoma of the endometrium.


Dysfunctional uterine bleeding. A classification.


Emphysematous vaginitis.

Emphysematous vaginitis.


Mucoid impaction of the bronchi in cystic fibrosis.


The perpetuation of hemophilia by mutation.


Mist tent therapy of the obstructive pulmonary lesion of cystic fibrosis.


The incidence of mental and physical handicaps in school age children of very low birth weight. II.


Serum levels of methicillin and ampicillin in newborn and premature infants in relation to postnatal age.


Cellular growth in human placenta. I. Normal placental growth.


Acute respiratory illness associated with Coxsackie B4 virus in children.


Urinary catecholamine excretion by healthy children. I. Daily excretion of dopamine, norepinephrine, epinephrine, and 3-methoxy-4-hydroxymandelic acid.


Coexistent megacolon and megaureter. Report of a case with normal vesical autonomic innervation.


Diagnosis and treatment: psychosocial aspects of well child care.


Skin infections and acute nephritis in American Indian children.


Skin dimples and rubella.

Skin dimples and rubella.


Cantharidin poisoning from ingestion of a "Blister Beetle".


Galactose-1-phosphate uridyl transferase actiivity in hemolysates of newborn infants.


Serum amylase activity in the newborn.

Serum amylase activity in the newborn.


The lack of association between the appearance of complement fixing antibodies and the recovery of virus in a child with congenital rubella.


American Jurassic symmetrodonts and Rhaetic "pantotheres". The molar morphology of the symmetrodonts Tinodon and Eurylambda from the late Jurassic of North America is virtually identical to that of so-called "pantotheres" from the Rhaetic of Wales. Therefore a primitive symmetrodont molar pattern was probably present in the phylogeny of pantotherian and tribosphenic molars. Occlusion of Tinodon and Eurylambda produced complex wear facets unlike the simple trigon-trigonid shear surfaces of Spalacotherium and Peralestes.


Fibrinogen from human plasma: preparation by precipitation with heavy-metal coordination complex. Potassium tetrathiocyanato-(S)mercurate II [K(2)Hg(SCN)(4)] is used in a mild and rapid procedure for the isolation of human fibrinogen from fresh plasma. The final product, 94 to 99 percent of which is coagulable by thrombin, represents an average yield of 80 percent and is stable in solution. It is free of plasmin, streptokinase-activatable plasminogen, and coagulation factors II, V, VIII, X and XIII. Sedimentation analysis reveals a single peak with a sedimentation coefficient equal to 7.0S at infinite dilution. Immunodiffusion on cellulose acetate results in two precipitin lines with rabbit antiserum to whole human serum. The fibrinogen precipitates are unusual in that they are flocculent and readily redissolve.


Radiation of hemocyanin: inactivation and reactivation of oxygen-carrying capacity. Oxygen-carrying capacity of hemocyanin from Limulus and Busycotypus (Busycon) decreases with increasing radiation, giving initial yield values for G(-O(2),) of 1.1 and 1.0, respectively. High radiation doses regenerate this capacity of Busycotypus hemocyanin. These effects are attributed largely to the dual nature of hydrogen peroxide, which, at low concentrations, oxidizes protein-bound copper and at high concentrations, that is, at high doses, reduces oxidized copper. The ability of hemocyanin to decompose hydrogen peroxide is relatively unaffected by irradiation, which suggests that copper atoms at the active sites are not all equivalent. The catalase-like activity of Busycotypus hemocyanin can be simulated by amino acid chelates of copper, including arginine, histidine, and glycine.


Deuterium oxide: direct action on sympathetic ganglia isolated in culture. Immature ganglia from chicks and rodents were maintained as organized, developing cultures for 2 months or more, during which time they were continuously exposed to deuterium oxide in their medium. Observations of the living cell communities with the light microscope indicated that deuteration within viable limits (up to 25 percent) accelerates and increases the growth of sympathetic neurons and favors their repeated subdivision as a very large size is attained, thus inducing them to recapitulate cyclically the early stages of neurogenesis. Living deuterated cells appear more opaque and heteromerous than control neurons; furthermore, electron micrographs reveal an unusual abundance of granular and fibrillar elements in the nuclei of both neurons and supporting cells. Sheaves of complexly organized fibrillar components appear in the neuronal perikaryon; and ribosomes, Golgi elements, and microtubules are conspicuously numerous. Both fine structure and function of these ganglia therefore appear to have been modified directly by action of the deuterium isotope.


Sex chromosomes in lizards.

Sex chromosomes in lizards. Karyotypes of many species of the genus Sceloporus support the generalization that there are no morphologically recognizable sex chromosomes in lizards; however, there is a marked sexual dimorphism in the karyotypes of Sceloporus jarrovi and Sceloporus poinsetti. During meiosis in males, whose diploid number of chromosomes is 31, preferential segregation of chromosomes from a trivalent results in heterogamety.


Disruption of hibernation caused by hypothalamic lesions. Lesions were made in the preoptic-anterior hypothalamic area or ventromedial nucleus of ground squirrels (Citellus tridecemlineatus). Four squirrels, two with preoptic damage and two obese hyperphagics, entered hibernation within 1 to 3 days. They all died after 11 to 12 days, shortly after all normal hibernating squirrels had awakened. Seven squirrels with preoptic damage, rendered hypothermic before being placed in the cold, died within 2 to 6 days.


Phenylketonuria: enduring behavioral deficits in phenylketonuric rats. The behavioral deficit in rats made "phenylketonuric" by ingestion of L-phenylalanine was evaluated 23 to 65 days following cessation of treatment. Animals treated from birth to 60 days showed significant deficit on reasoning and discrimination learning tests but not on discrimination reversal sets. Animals treated from 30 to 60 days showed significant deficit only on the reasoning test.


Partial pressure of anesthetic gases and their mode of administration.


Conservative management of eosinophilic infiltration of the gastrointestinal tract. Report of a case.


Villous adenoma of the rectum associated with severe electrolyte imbalance. Report of a case.


Air-contrast examination of the colon: an entity of the past.


The importance of fluoroscopic tube placement during gastric analysis.


The effect of vasoactive substances on the circulation and glucose absorption of an isolated jejunal loop in the dog.


Comparison of D(+)xylose with glucose in the study of the pathophysiology of the postgastrectomy dumping syndrome.


Effect of glucose and glycine solution on the circulation of the isolated jejunal loop in the dog.


Intestinal fat absorption in cirrhosis of the liver. Effect of carbon-chain length and degree of saturation of fatty acids.


Nutritional studies in patients with dumping syndrome. I. Subjects with postcibal symptoms.


Insulin effects on gastric secretion and blood electrolytes modified by injected potassium.


Lactase deficiency in ulcerative colitis, regional enteritis, and viral hepatitis.


Progressive hypersplenism after portacaval anastomosis. Report of 3 cases.


Concentration of gastric-juice proteins in a patient with Menetrier's disease. Report of a case.


Concentration and localization of calcium in frog gastric mucosa.


Development of active sugar and amino acid transport in the yolk sac and intestine of the chicken.


Functional hypertrophy and atrophy of the salivary glands of rats.


Influence of pancreas on gastric secretion in dogs.


Oxidative and transfer site of glucose-14C in dog parotid gland.


Dissociation of potassium and glucose efflux in isolated perfused rat liver.


Hormonal effects on accumulation of naturally occurring amino acids in vivo and in vitro.


Diminished responsiveness to insulin in the growth hormone-treated normal dog.


Enrichment of depot fat with odd and even numbered medium chain fatty acids.


Comparison of heparin-released and epinephrine-sensitive lipases in rat adipose tissue.


Role of hepatic adenosine triphosphate in BSP transport and metabolism in vivo.


Metabolism of exogenous triglyceride by the isolated perfused rat heart.


Prostaglandin influences on intraocular pressure and pupil size.


Metabolic rate of camels: effect of body temperature and dehydration.


Reticuloendothelial stimulation and estrone-induced hypocholesteremia.


Temperature regulation and evaporative cooling in the ostrich.


Isometric tension of glycerinated muscle fibers following adrenalectomy.


Some aspects of hepatic and renal excretion in Myxine.


Countercurrent multiplication by the thin loops of Henle.


Movement of Na and K across and within frog skin.


Internal iron exchange in the rat.

Internal iron exchange in the rat.


Extracellular space of rat cerebral cortex.


Free water reabsorption during solute diuresis in normal and potassium-depleted rats.


Mechanism of hydrazine excretion by the mammalian kidney.


Renal localization of albumin and its function in the concentrating mechanism.


Extravascular renal albumin.

Extravascular renal albumin.


Interactions of K, Na, and vagal stimulation in the S-A node of the rabbit.


Location of pacemaker in chick embryo heart at the time of initiation of heartbeat.


Interaction between Na, Ca, Mg, and vagal stimulation in the S-A node of the rabbit.


Neurogenic control of thrombolysis.

Neurogenic control of thrombolysis.


Left ventricular function and tissue hypoxia in irreversible hemorrhagic and endotoxin shock.


Effects of acetylcholine on transmembrane potentials in frog ventricle.


Transcapillary fluid movement during vasopressin and bradykinin infusion.


Catecholamine sensitivity of cat leg vessels after sympathectomy.


Dynamic response characteristics of carotid sinus baroreceptors.


Mesenteric blood flow and vascular volume in hemorrhagic shock.


Influence of blood oxygen saturation on pressure-flow curve of dog hindleg.


Cutaneous and skeletal muscle vascular responses to hemorrhage and irreversible shock.


Time-dependent responses of brown fat in cold-exposed rats.


Hemodynamic and metabolic responses of infused low molecular weight dextran.


Effects of acute and chronic hemolysis on iron metabolism in the Sprague-Dawley rat.


Metabolic changes in rats exposed to an oxygen-enriched environment.


Adaptation to cold in three hours.

Adaptation to cold in three hours.


Serum enzymes in sex-linked (Duchenne) muscular dystrophy.


The orthostatic hypotension syndrome of Shy-Drager. A clinicopathologic report.


Western encephalitis and cerebral ontogenesis.


Syndrome of subacute generalized muscular stiffness and spasm.


Creatin kinase in human tissues.

Creatin kinase in human tissues.


An electron microscopic study of myotonic dystrophy.


Solitary intracranial plasmacytoma.

Solitary intracranial plasmacytoma.


Control mechanisms in cortical epileptogenic foci. "Surround" inhibition.


Evaluation of the urea washout pyelogram and urography in the assessment of renovascular hypertension. The urea washout (UWT) modification of the intravenous pyelogram was used to study 146 hypertensive patients in order to detect the presence of significant renovascular abnormalities. A positive result was obtained in 55 patients and direct confirmation of main renal artery stenoses by selective renal arteriography was obtained in 26. Bilateral abnormalities were confirmed in seven of the 26 patients. No false-negative results were encountered. The usefulness of this test as a comprehensive screening test is outlined. It demonstrated a high degree of accuracy in the diagnosis of significant unilateral or bilateral main renal artery stenosis in addition to the detection of diffuse intrarenal arteriolar disease. It was of value in the postoperative assessment of operative repair of main renal artery defects. The urea washout test embodies both an anatomical and a physiological approach in the roentgen diagnosis of curable renovascular hypertension. The altered physiology resulting from significant main renal artery stenosis makes possible the use of the urea washout intravenous pyelogram. The value of other forms of intravenous pyelography is described.


Pneumonia in Indian and Eskimo infants and children. I. A clinical study. Ninety-seven Indian and Eskimo infants and children who suffered 112 episodes of pneumonia were the subjects of a prospective study carried out at the Charles Camsell Hospital, Edmonton, Alberta, from August 1963 until August 1964. Investigation included viral studies and an evaluation 10 days after admission. The patients were divided into four diagnostic categories and a comparison was made between cases of bacterial and viral origin. The frequency of right-sided disease, particularly of the upper lobe and/or dependent segment involvement, is described. An evaluation of physical signs is attempted. The problem of recurrent pneumonia and the differential diagnosis of tuberculosis in Indian and Eskimo children with pneumonia is discussed.


The irrigation smear--a new cytodiagnostic technique for the detection of cancer of the uterine cervix. Using the Davis cytopipette, cytologic smears were prepared from 2014 patients; 1367 of these specimens were obtained by the patients themselves. The series included 57 cases of carcinoma or atypia of the cervix, and 50 (88%) of these cases were found to have abnormal cells in the irrigation smear.Cytopipette samples were obtained by a nurse from 647 Eskimos, but cell preservation in this group was not satisfactory because of a delay of several weeks in preparing the smears. Accurate results depend also on specific training of the personnel reading the smears because fewer cells may be present in these smears than in cervical scrape smears.The irrigation smear is recommended as a reasonably accurate method of screening women for cancer of the cervix if they are not being examined regularly by the cervical scrape method. Hospital admissions of females may be a fruitful source of such cases.


Urinary steroid pattern in male hypogonadotrophic hypogonadism. During clinical studies on a 34-year-old man with marked hypogonadism secondary to pituitary gonadotrophin insufficiency, an attempt was made to determine whether the testes were capable of androgen production when stimulated by exogenous chorionic gonadotrophin (A.P.L.).Androgen excretion before and after chorionic gonadotrophin administration was studied. Total and fractionated 17-ketosteroid patterns suggested a severe Leydig cell deficiency which was confirmed by testicular biopsy.Panhypopituitarism was considered excluded by a normal response to metyrapone ditartrate, by a normal serum PBI and a normal radioactive iodine uptake. Genetic disorders were likewise excluded to the extent possible by determining that the chromosome pattern was normal and by determining that no similar condition existed in another member of the same family. The association of anosmia with gonadotrophin insufficiency in this case suggests a primary disorder in the hypothalamo-mamillary-tuber cinereum area.


Creation of intramyocardial pathways to channel oxygenated blood between ventricular arteriolar zones: a preliminary report.


Chandler BM: Traumatic aneurysm of thoracic aorta: a case presenting as a coarctation.


Cytology in the detection of early carcinoma of the uterine cervix.


"Man errs so long as he strives".

"Man errs so long as he strives".


The effect of alcoholism on the absorption of folic acid (H3-PGA) evaluated by plasma levels and urine excretion.


Relationship between serum phosphate concentration and bone resorption in osteoporosis.


Studies on the pathogenesis of acute inflammation. 8. The failure of ADP and other nucleotides to modify phagocytosis and clumping by human leukocytes.


The determination of tryptophan in plasma, liver, and urine.


The use of benzene phosphinic acid to prepare mixed samples of 55Fe and 59Fe for liquid scintillation counting.


Radiophosphate "closed" system efflux rate constant and ATP metabolism in intact human red cells.


The effect of clinical dextran on platelet aggregation, adhesion, and ADP release in man: in vivo and in vitro studies.


Hemoglobin M Reserve: studies on identification and characterization.


Characteristics of RNA synthesized in vitro by lymphocytes of chronic lymphocytic leukemia.


Presidential address. The whetstones.

Presidential address. The whetstones.


Antineutrophilic serum, its use in studies of white blood cell dynamics.


Changes in the amino acid composition of proteolipids of white matter during maturation of the human nervous system.


RNA synthesis in mouse brain.

RNA synthesis in mouse brain.


Saponifiable fatty acids of myelinated and unmyelinated nerve fibres of the garfish.


Ammonia and urea in the brain of garden dormice during hibernation.


The effect of a nutritional pyridoxine deficiency on free amino acids and related substances in mouse brain.


The effect of sulphydryl and other disulphide reducing agents on choline acetyltransferase activity estimated with synthetic acetyl-CoA.


Effect of inanition during the neonatal period on discrimination learning and brain biochemistry in the albino rat.


Uptake and metabolism of [14C] serotonin in rat brain.


Long-chain bases of brain and spinal cord of rabbits.


Immunochemical studies of organ and tumour lipids. XVII. The existence of two complement-fixing systems involving cerebroside.


6-phosphogluconate dehydrogenase (6PGD) activity in the cervical mucus and vaginal fluid in benign and malignant gynaecological lesions.


Oestrogen metabolism in oligomenorrhoeic hirsute women.