The likelihood ratio and the algebra of diagnosis.


Hemolysin production in young rabbits.

Hemolysin production in young rabbits.


Response of wild rats (Rattus norvegicus) bred in captivity to oral inoculation with Salmonella pullorum, Salmonella newington, and Salmonella enteritidis.


The influence of the route of administration of Newcastle disease virus on host response. I. Serological and virus isolation studies.


The renal clearance and plasma binding of vasopressin in the dog.


Stimulation of the reticuloendothelial system in burned rats infected with Pseudomonas aeruginosa.


Bilirubin encephalopathy in the Gunn rat: a fine structure study of the cerebellar cortex.


The responsibilities of excellence. Third Harvey Cushing Oration.


Neuropathological changes following treatment of human malignant disease with Langat virus.


Cholesterol content of xanthogranulomas of the choroid plexus.


The membranous coverings of neural tissues: an electron microscopy study.


Intracarotid coomassie blue eye as an aid in the surgery of intracranial vascular lesions.


Evaluation of the auditory system following surgical section of the vestibular division of the eighth cranial nerve.


Elective circulatory arrest in intracranial surgery. Successful treatment of an aneurysm of the basilar artery with a method of open-chest circulatory arrest.


Prolonged measurement of experimental intracranial pressure using a subminiature absolute pressure transducer.


Alteration of the blood-brain barrier with hyperventilation.


Adenohypophysial carcinoma. Case report.


The pathological basis for postural (intermittent) exophthalmos. Case report.


Aneurysm of the posterior cerebral artery with unexpected postoperative neurological deficit. Case report.


Penetrating skull wound from a pair of scissors. Case report.


Multiple meningiomas of the spinal canal. Case report.


Temporal lobectomy.

Temporal lobectomy.


Electron-microscopic localization of tritiated norepinephrine in rat brain: effect of drugs.


Steric aspects of adrenergic drugs. V. Beta adrenergic blocking effects of optical isomers of methoxamine and isopropylmethoxamine.


Steroid-induced hypertension in the rat. A study of the effects of renal artery constriction on hypertension caused by deoxycorticosterone.


Sulfate-containing mucosubstances of dog gastric mucosa.


Automation in clinical laboratories. The present state and future uses of automation proceedings of a workshop conference.


The early stage of liver injury in the alcoholic.


Protein anabolism and fatty liver of the alcoholic.


The evolution of human cirrhosis deduced from observations in experimental animals.


Acid-base disturbances in patients with cirrhosis of the liver.


Functional renal failure with cirrhosis. The effect of plasma expansion therapy.


Non-hemoglobin heme intermediates in the biosynthesis of bile pigments.


Acute intermittent porphyria: effect of diet and griseofulvin.


Recent developments in our knowledge of the urobilins.


Comparison of effects of pH and concentration gradients on ammonia transport in the human jejunum.


Ex vivo pig liver perfusion for acute hepatic failure: bile salt composition of pig bile during perfusion.


The origin of complete and mosaic mutants from mutagenic treatment of single cells.


A measure of care.

A measure of care.


Effect of an oxytocic on umbilical cord venous pressure.


Hemangiomas of the ovary and the uterine cervix.


Intrauterine pH of women using stainless steel contraceptive device.


Pseudo-Meigs' syndrome with mucinous cystadenoma. Report of a case in which the effusions contained atypical cells.


Fatal air embolism in pregnancy resulting from an unusual sexual act.


Robert Pelvis: a rare pelvic contraction.


Bell's palsy in pregnancy.

Bell's palsy in pregnancy.


Women's reactions to pelvic examination.


Reactions of women to gynecologic examination.


Anaerobic postoperative pelvic infections.


Irradiation ulcer of the urinary bladder.


A critical view of vacuum aspiration: a new method for the termination of pregnancy.


Appendiceal carcinoma incidental to gynecologic operations.


Pitressin hemostasis in conization biopsy of the cervix.


Conservative management of endometriosis: follow-up observations of progestin therapy.


Angiomyxoma of the umbilical cord with atrophy of an umbilical artery.


Benign vaginal adenosis.

Benign vaginal adenosis.


Lipid metabolism in cultured cells VII. Linoleic acid content of cells grown on lipid-free synthetic medium.


Deferoxamine and sweat iron.

Deferoxamine and sweat iron.


Characterization of the Tacaribe group of arboviruses. I. Propagation and plaque assay of Tacaribe virus in a line of African green monkey kidney cells (Vero).


Effect of section of the corpus callosum on cortical after-discharge patterns in the cat.


Immunologic studies in thermal injury: heterophile antibodies.


Effect of some analogues of bradykinin upon vascular permeability.


Comparative effects of some immunosuppressive and anti-inflammotory drugs on allergic encephalomyelitis and adjuvant arthritis.


Influence of age and dietary stress on hexobarbital activity in mice.


Rubella hemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells.


Rubella complement fixing antigen prepared by alkaline extraction of virus grown in suspension culture of BHK-211 cells.


Ventilation of newborn lambs by means of a donor lung.


Papillomatous growth in sole from Wakasa Bay area.


Direct percutaneous determination of systemic blood pressure and production of renal hypertension in the cat.


Automatic, high-resolution analysis of urine for its ultraviolet-absorbing constituents.


Effect of melatonin on thyroid hormone secretion rate and feed consumption of female rats.


Studies with clearing factor V. State of tissue lipases after injection of heparin.


DNA in human pituitary glands.

DNA in human pituitary glands.


Isolation of two enteroviruses, possible "prime" strains of coxsackie A type 17 virus.


Intestinal transport of calcium and phosphate in experimental magnesium deficiency.


Studies on insulin effect on permeability of dermal connective tissue.


Factors influencing the inotropic effect of corticosteroids.


Comparison of endogenous and exogenous creatinine clearances in man.


Myocardial lesions: spontaneous development in captive ground squirrels.


Additional evidence for the participation of 5-hydroxytryptamine in the intestinal response to morphine.


2-Amino-1,4-naphthoquinone, an oxidation product of 2-amino-1-naphthol.


Source of stimulation of tumor inocula by lethally irradiated cells.


Potentiation of diethylstilbestrol induced aortic ruptures of turkeys with thiouracil.


Metabolism of puromycin aminonucleoside in the normal, "pre-nephrotic," and nephrotic rat.


Metabolic alterations of catecholamines and other compounds in elasmobranch tissues.


Reutilization of presumably degraded radioactive label from a chromosomal fraction of homologous and heterologous cells.


Effects of cortisone and insulin on tumor weights, urinary glucose and nitrogen in rats.


Effect of asiaticoside on wound healing in the rat.


Effect of dietary factors on prothrombin response to acenocoumarin in guinea pigs.


Plasma villikinin.

Plasma villikinin.


Hepatic microsomal activities in rats with long and short sleeping times after hexobarbital: a comparison.


Carbon dioxide seizures in immature rats.


Homeothermic development of the young chick.


The antiviral activity of caprochlorone.


Histopathology of guinea pigs with cholesterol-induced anemia.


Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature.


Lipid mobilizer hormone in triton hyperlipemia.


A simple and inexpensive device for restraining rodents.


Granulocytopoiesis in germfree mice.

Granulocytopoiesis in germfree mice.


Effective immunotherapy of Friend virus infection.


Periodicity in the cytoplasm of freeze-cleaved sheep erythrocytes.


Vitamin D-induced calcium binding factor in rat intestinal mucosa.


Adenosine triphosphate in the in vitro hemolytic tests for paroxysmal nocturnal hemoglobinuria.


Relationship of mast cell population and endogenous histamine concentration in the canine stomach.


An excitatory adrenergic alpha receptor mechanism of terminal guinea-pig ileum.


In vivo fatty acid synthesis in adipose tissue and liver of meal-fed rats.


Hypoxic decompression and fat embolism.

Hypoxic decompression and fat embolism.


Investigation of correlations occurring between the urinary excretion of calcium, nitrogen, phosphorus and hydroxyproline after calcium administration in articular disease.


Analgesic nephropathy in Australia.

Analgesic nephropathy in Australia.


Experiences of intra-articular administration of radioactive gold.


Practical and training aspects of teaching ventilatory resuscitation.


Mechanical hemolysis in patients with valvular heart disease and valve prosthesis.


Myocardial infarction shock revisited.

Myocardial infarction shock revisited.


Unusual patterns of conduction produced by pacemaker stimuli.


The true venous pulse wave, central and peripheral.


Hemodynamic effects of propranolol in patients with Fallot's tetralogy.


The normal atrial electrocardiogram: morphologic and quantitative variability in bipolar extremity leads.


Relationship between the position of chest electrodes (Frank and SVEC-3 systems) and the anatomic position of the heart.


The intracardiac electrocardiogram of human atrioventricular conducting tissue.


Effects of acute digitalization on cardiovascular dynamics in experimental, surgically induced heart block.


Pacemaker attachment to the cardiac conduction system in experimental heart block.


The effect of external compression on the murmur and thrill of the straight back syndrome.


Discrimination of the quantitative ultralow-frequency ballistocardiogram in coronary heart disease.


Blood and urinary vitamin levels as potential indices of body stores.


Biochemical alterations in thiamine deficiency--their interpretation.


Biochemical and physiological changes in vitamin B6 deficiency.


Biochemical and hematologic lesions in folic acid deficiency.


Vitamin B12 deficiency with emphasis on methylmalonic acid as a diagnostic aid.


Vitamin C requirements in stress.

Vitamin C requirements in stress.


Tocopherol deficiency in man.

Tocopherol deficiency in man.


Are we looking at the right enzyme systems?


Biopterin and folic acid deficiency.

Biopterin and folic acid deficiency.


Tocopherol storage and depletion in adipose tissue and plasma of normal and diabetic human subjects.


Importance of zinc in human nutrition.

Importance of zinc in human nutrition.


Changing concept of malnutrition.

Changing concept of malnutrition.


Dietary carbohydrate in hyperlipemia.

Dietary carbohydrate in hyperlipemia.


Hepatic alcohol dehydrogenase in alcoholic addicts with and without hepatic damage.


Multiple jejunal biopsies in adult celiac disease.


The effect of lipid on chymotrypsin assay in stools.


Effects of exposure, freezing, and radiation on explanted gastric mucosa.


Segmental hepatic angiography. A preliminary report.


Gastric aspiration in fiber optic endoscopy.


Abbreviated Histalog gastric analysis. Comparison with peak acid output.


Intake-excretion studies of fat and nitrogen in 7 patients with hepatolenticular degeneration (Wilson's disease).


Acute pancreatitis affecting the transverse colon. Report of a case.


Calcium content of duodenal juice.

Calcium content of duodenal juice.


Proteus mirabilis enterocolitis following abdominal irradiation. Report of a case.


Gastrocolic fistula secondary to benign ulcer in a patient given steroids. Report of a case.


Colostomy care: natural evacuation or irrigation?


Do corticosteroids cause peptic ulcer? Another point of view.


Time sharing: its promise and problems.

Time sharing: its promise and problems.


Engineering problems in design and utilization of hyperbaric oxygenation equipment.


Effect of dosage and influenza vaccine content on antibody response in medical students.


Citizen and surgeon.

Citizen and surgeon.


The revised combined operation with selective gastric vagotomy.


Fifteen years' experience with portosystemic venous shunting operations.


Liver trauma.

Liver trauma.


Treatment of the common bile duct in pancreatitis.


Surgical management of adrenocortical hyperfunction.


Thoracocervical occlusive disease.

Thoracocervical occlusive disease.


Videofluoroscopic observations on various types of pyloroplasty.


Hirschsprung's disease: a rare cause of constipation in patients following surgical correction of imperforate anus. Report of two cases.


Preservation of organ function during death.


Lessons from perfusion with broad application to general surgery.


Clinical estimation of acute blood loss by the Tilt Test.


Foreign bodies in the heart.

Foreign bodies in the heart.


Omit the tube.

Omit the tube.


Bile duct cystadenoma of the liver.

Bile duct cystadenoma of the liver.


Pancreatic heteropia.

Pancreatic heteropia.


Mediastinoscopy.

Mediastinoscopy.


Parenteral administration of 6-alpha-methylprednisolone-21- acetate. I. Intra-articular injection: comparison with hydrocortisone acetate.


Partial nephrectomy. Indications and technique.


Retinal vasculitis associated with anterior uveitis.


Insulin depression of human gastric secretion.


Clinical electroretinography. II.

Clinical electroretinography. II.


Food and thought: a sociologic study of food cultists.


Idiopathic hemochromatosis. II. Diagnosis and treatment.


Preventing recurrences of congestive heart failure.


International conference on malnutrition, learning, and behavior.


The dietitian in private practice.

The dietitian in private practice.


Collecting dietary information from groups of older people.


Diet therapy for inborn errors of amino acid metabolism.


Flotation as an aid in the treatment of decubitus ulcers.


Memory and serum ribonuclease activity in the aged.


New aspects of cardiovascular disease in the aged.


Psychiatric disorders common to psychiatric and nonpsychiatric patients in nursing homes.


Diabetogenic hyperinsulinism: pathogenesis and implications of sulfonylurea-induced hypothyroidism.


Effect of pentylenetetrazol (Metrazol) on blood cholesterol.


Lighting needs for older eyes.

Lighting needs for older eyes.


Resistance of long-lived lymphocytes and plasma cells in rat lymph nodes to treatment with prednisone, cyclophosphamide, 6-mercaptopurine, and actinomycin D. The cells of the popliteal lymph nodes of rats were labeled for 4 days after a secondary immunological stimulus. 31 days after the last dose of tritiated thymidine, groups of rats were started on courses of daily, intraperitoneal injections of prednisone, cyclophosphamide, 6-mercaptopurine, or actinomycin D. The initially low doses of these agents were doubled in successive weeks until either lymphoid hypoplasia or death occurred. Rats from each group were killed weekly, and the percentages of persisting, labeled small lymphocytes in the popliteal nodes were determined. Sections of these nodes were examined for persisting, labeled plasma cells. The per cent of lymphocytes labeled increased while the total number of lymphocytes decreased during treatment with prednisone and cyclophosphamide. Prednisone decreased the numbers of long-lived plasma cells, but these cells were preferentially resistant to cyclophosphamide. Neither 6-mercaptopurine nor actinomycin D had an appreciable effect on lymphoid tissues histologically nor on the proportions of labeled, long-lived lymphocytes and plasma cells before causing the deaths of the rats receiving them. These results indicate that long-lived lymphocytes and plasma cells survive treatment with the immunolytic drugs studied, and that long-lived lymphocytes are specifically resistant to prednisone and cyclophosphamide. We believe these results have an application to the attempts to find drugs useful in the treatment of immunologic rejections of organ transplants, and for therapy of autoimmune diseases.


The influence of antibodies on immunologic responses. I. The effect on the response to particulate antigen in the rabbit. The influence of antibody on antibody formation to particulate antigen was examined in the rabbit with special reference to the importance of immunoglobulin type, the amount and relative proportion of antigen and antibody involved, and the specificity of this influence. 19S as well as 7S antibody was shown to be an effective inhibitor of antibody formation, although there was some evidence that 7S antibody was the more efficient of the two in doing so. The inhibitory effect of antibody was found to be specific for homologous antigenic determinants. Both 19S and 7S antibody were also able to enhance antibody formation. In contrast to the suppressive phenomenon, however, enhancement appeared to be nonspecific since antibody reactive with homologous (sheep red blood cell) determinants could enhance the response not only to homologous determinants but to heterologous (dinitrobenzene) determinants conjugated to the red blood cells as well. Smaller amounts of antibody were needed to enhance than to suppress antibody formation, and suppression and enhancement depended to some extent on the amount of antigen as well as to the amount of antibody used. The enhancing and suppressing influence of antibody on antibody formation appeared to be exerted concomitantly, for the response to some antigenic determinants was sometimes suppressed at the same time that the response to others was enhanced. It is suggested that enhancement or suppression of immunologic responses by antibody represents a different balance of at least two competing factors operating together: specific neutralization of appropriate determinants thus decreasing the total effective concentration of these determinants available to stimulate the formation of antibodies, and a nonspecific increase in the availability of antigen to immunologically competent cells.


The immune response to sheep erythrocytes in the mouse. I. A study of the immunological events utilizing the plaque technique. The direct and indirect plaque technique for the detection of antibody-forming cells against sheep erythrocytes was utilized for the investigation of a number of biological parameters of the primary and secondary immune response on a cellular level. The sequential pattern of 19S followed by 7S antibody formation was elicited in the primary response after a latent period of at least 1-2 days and 2-3 days respectively. The secondary response initiated 140 days after primary immunization, in contrast, was characterized by the simultaneous appearance of 19S and 7S antibody-forming cells after an observed latent period of 2-3 days. The cellular dynamics of the recruitment phase of the respective immunoglobulins in the primary and secondary response was interpreted as evidence for the derivation of the two classes of immunoglobulins from separate progenitors. The 19S antibody-forming cells were derived predominantly by a process of transformation and maturation and 7S antibody formers by a process of cellular division with a doubling time of about 12 hr. The draining lymph node exhibited maximal immunological reactivity due to its capacity to retain the particulate antigen. This capacity was considerably enhanced in the sensitized draining lymph node. Minimal cellular activity was also noted in distal lymphoid tissues which included the thymus. Focal cellular activity was observed in the draining lymph node for 60 days after immunization. Subsequently, very low level plaque-forming cellular activity was observed in association with persistence of maximal antibody activity. The appearance at 120 days of a generalized peak of cellular activity in lymphoid tissues throughout the host was considered an explanation for this discrepancy. The change in distribution of cellular antibody-forming activity, from a local to a generalized lymphatic response during the late phase of the immune response, implied a fundamental alteration in homeostatic mechanisms associated with maintenance of immune reactivity. Further manifestations of such an alteration were indicated by the appearance of 2-ME-sensitive 7S antibody nearly 3 months after primary intradermal immunization, which in the ensuing 5 months was associated with, and inversely related to, two major fluctuations in 2-ME-resistant 7S antibody. Evidence for the existence of immunological memory in the 19S system was not established in the present work. 19S anamnesis, for which evidence was derived from measurements of circulating antibody levels, was interpreted from cellular studies as the result of the substantial activity of previously uncommitted 19S lymphoid cells in distal lymphoid tissue associated with previously committed 19S cells contained in the draining lymph node.


Sequential changes in classes of RNA during compensatory growth of the kidney. The synthesis of nuclear precursors of rRNA and of cytoplasmic mRNA has been estimated in mouse kidneys following contralateral nephrectomy. 1. The production of nuclear rRNA parallels mitotic activity in the proximal tubule cells. Its peak is 2 days after nephrectomy; there may be a second peak at 8 days. 2. The production of mRNA is almost the reciprocal of rRNA production. It is least at 2 days and most at 4 days after nephrectomy. It may also decrease immediately after nephrectomy. 3. Growing kidney cells may build a store of ribosomes before they elaborate mRNA. The sequential relation between rRNA and mRNA synthesis raises the possibility that production of rRNA could regulate the production of mRNA and that the stimulus to compensatory hypertrophy might need to act only long enough to set into motion the machinery for making rRNA, either directly or as a consequence of exhausting mRNA.


Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. Hemolytic disease characterized by slight anemia, reticulocytosis, hemosiderosis, extramedullary hematopoiesis, and positive indirect antiglobulin (Coombs') tests and renal disease with proteinuria, hypoalbuminemia, and glomerular lesions were produced in Swiss mice by neonatal intraperitoneal inoculation of cell-free filtrates prepared from the spleens of old NZB/Bl mice. Lymphoid cell and plasma cell hyperplasia as well as hypergammaglobulinemia occurred in some of these inoculated mice. Type "C" murine oncogenic virus-like particles, indistinguishable from those previously described (1), were shown by electron microscopic study to be present in distinctive locations, notably in the basal foldings of convoluted tubules in the kidneys of a newborn NZB/Bl mouse, old NZB/Bl mice, a CBA x NZB F(1) hybrid mouse, and a Swiss mouse inoculated with NZB/Bl spleen cell-free filtrate. These observations point to two (perhaps related) circumstances which may be requisites for the pathogenic action of this newly discovered virus within and outside the strain NZB: infection of newborn, or infant, mice; persistent, possibly tolerant, infection of adult mice.


Benign and malignant hypertension after adrenal enucleation in the rat. Relationship to salt intake, response to hydrochlorothiazide, and similarity to essential hypertension. Adrenal-enucleated, mononephrectomized rats given a high salt diet rapidly develop malignant hypertension, characterized by the presence of necrotizing vascular lesions in a number of organs and tissues. If a normal salt intake is provided, or if hydrochlorothiazide is given together with a high salt diet, there is, instead, the delayed onset of benign hypertension which either stabilizes or increases in intensity extremely slowly; Such animals display few, if any, pathologic vascular changes other than occasional focal glomerular hyalinization, show insignificant cardiac enlargement, and do not exhibit alterations in the serum sodium or potassium. Occasional animals behave atypically and develop malignant hypertension despite normal salt consumption, demonstrating that in susceptible rats excess salt is not essential to this disorder. Hydrochlorothiazide given to rats that imbibed distilled water postoperatively prevented hypertension entirely for 97 days, when one of eight rats developed mild hypertension and some others reached what is regarded as a prehypertensive range. It is concluded that adrenal regeneration provides a physiological milieu favorable to the development of benign hypertension, which is not, as a rule, manifest until regeneration is complete. Salt excess converts the response into one in which malignant hypertension begins during regeneration and worsens rapidly thereafter until death. The course and findings are compared with those of the benign and malignant phases of clinical essential hypertension, and the implications of the similarities are discussed.


The effect of Na2SO4 on urinary acidification in chronic renal disease.


Object anxiety and primitive defenses in schizophrenia.


Methodological formalism in psychiatric research.


The influence of amount and type of information on the rating of affect.


Vaccinial vulvo-vaginitis.

Vaccinial vulvo-vaginitis.


Effect of focal cerebral lesions on perspective and movement reversals.


Induction of ovulation by cyclical hormone therapy.


The relationship between childhood neurotic symptomatology and later schizophrenia in males and females.


Diagnosis of hydatidiform mole by amnioscopy. Preliminary report.


Surface forces in biological material. Measurement of surface tension by drop volume.


A nonallergist looks at allergy.

A nonallergist looks at allergy.


A deluded patient; a psychiatric nursing care study.


Hypertension and hypokalemic alkalosis associated with underproduction of aldosterone.


Postoperative follow-up of restitution procedures in the orbicularis oris muscle after operation for complete bilateral cleft of the lip.


The effect of surgery on maxillary growth and cleft width.


Subtotal removal of the upper and lower lateral cartilages and overlying adipose tissue in rhinoplasty.


Complications of rhytidectomy.

Complications of rhytidectomy.


Alar collapse.

Alar collapse.


Prolonged oliguric renal failure after electric burns.


A simple instrument for ear piercing.

A simple instrument for ear piercing.


Proteus-staphylococcus synergism in punched out ulcers.


The philtrum of the upper lip.

The philtrum of the upper lip.


Council on dental education. Report on graduate and postgraduate programs in dentistry 1954-1955.


Rules for selective grinding. Occlusal equilibration. Correction of occlusal disharmonies.


Pollution in the Great Lakes.

Pollution in the Great Lakes.


Radar observations of locust swarms.

Radar observations of locust swarms.


Cell aggregation: its enhancement by a supernatant from cultures of homologous cells. A supernatant medium has been prepared from living embryonic neural retina cells which specifically promotes their histogenetic aggregation. Its function is dependent upon at least two experimentally separable steps: selective uptake and functional utilization.


Comparative metabolism of copper and zinc in patients with Wilson's disease (hepatolenticular degeneration).


Cardiac and pulmonary fibrosis during methysergide therapy for headache.


The effects of the protracted administration of the chelating agent, sodium diethyldithiocarbamate (dithiocarb).


Acute hemolytic anemia associated with administration of alkylating agents: report of two cases due to cyclophosphamide and review of the literature.


Iron absorption and utilization in chronic nephritis.


The differentiation of Klebsiella from Aerobacter species by sensitivity to cephalothins and penicillins.


Infectious mononucleosis treated with chloroquine. A double-blind study of 40 cases.


In vitro and clinical effects of cephaloridine: a semisynthetic antibiotic.


Fetal survival with premature delivery in complications of pregnancy.


Maternal death associated with premature rupture of the membranes. An analysis of 54 cases.


Altered glucose metabolism in pregnancy. Its determination and fetal outcome.


Abortion deaths in California.

Abortion deaths in California.


Routine use of radiogold following operation for ovarian cancer.


Pelvic retroperitoneal fibrosis with response to prednisolone.


The value of preoperative radiation therapy in stage I carcinoma of the uterine corpus.


The linear accelerator in the treatment of cervical cancer. A decade of experience.


Thermography in the detection of breast malignancy.


Estrogen metabolism in the polycystic ovary syndrome. Effect of ovarian wedge resection and clomiphene.


Parental smoking and perinatal mortality.


A simplified gas chromatographic method for large numbers of urinary pregnanediol determinations.


Hirsutism and evaluation of the dexamethasone suppression and chorionic gonadotropin stimulation test.


Metabolism of human cervical tissues. A radioautographic study.


Fine structure of human endocervical epithelium.


Comparative bacteriology of the endocervical mucus.


DNA content of cervical intraepithelial neoplasia studied by two-wavelength Feulgen cytophotometry.


Technical modifications of the 6-phosphogluconate dehydrogenase test of the vaginal fluid.


Detection of preinvasive and early invasive cancer by 6-phosphogluconate dehydrogenase determinations.


Histologic study of the endometrium of intrauterine contraceptive device users.


Endometrial histology associated with an intrauterine contraceptive device.


The plasminogen activator content of the myometrium in nonpregnant, pregnant, and parturient women.


Analgesia in obstetrics. The effect of analgesia on uterine contractility and fetal heart rate.


Prognostic index for vaginal delivery in breech presentation at term. Prospective study.


Single-dose caudal anesthesia: its effect on uterine contractility.


Effects on fetal heart rate and fetal pO2 of oxygen administration to the mother.


Fetal morbidity following potentially anoxigenic obstetric conditions. V. Organic heart disease.


Incidence of twin births among the Chinese in Taiwan.


Fatal Candida septicemia developing after hysterectomy and transfusion.


Modified O'Connor-O'Sullivan retractor for pelvic surgery.


Splenic rupture in sarcoidosis. Report of an unusual case.


Comparative tuberculin testing. Intradermal gun versus intradermal needle.


A chemical determination of isoniazid in serum.


Serologic identification of the atypical mycobacteria and its value in epidemiologic studies.


The place of vaccination in tuberculosis control.


The effect of oxygen breathing on arterial blood gases in patients with chronic airway obstruction living at 5,200 feet.


Occupational diability in patients with chronic airway obstruction.


Studies on pulmonary secretions. II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy.


Goodpasture's syndrome. A review with report of a possible case with apparent recovery.


Ultrasonographic characteristics of malignant melanoma.


Massive preretinal retraction. A biomicroscopic study.


Vitreoretinal traction in serous and hemorrhagic macular retinopathy. A biomicroscopic study.


Descemetopexy. Surgical reattachment of stripped Descemet's membrane.


Transient glaucoma after basal iridectomy.


Acute tuberculous panophthalmitis.

Acute tuberculous panophthalmitis.


Pigmented iris and retrocorneal membrane simulating an iris melanoma.


Acrocephalosyndactyly (Apert's syndrome).


Mitochondrial metabolism in ischemic injury.


Residency training in pathology.

Residency training in pathology.


Spontaneous closure of ventricular septal defects. Anatomic evidence in three patients.


Collagenolytic activity and collagen resorption in experimental cirrhosis.


Primary squamous cell carcinoma of the rectosigmoid portion of the colon.


Connective tissue composition of canine arteries. Effects of renal hypertension.


Optical-to-tactile image conversion aids for the blind.


Possible aid for the deaf through bio-engineering.


Perception of time by hemiplegic patients.


Alterations of cardiovascular control in high spinal myelomalacia.


Open-lung biopsy.

Open-lung biopsy.


Strangulated umbilical hernia with external fecal fistula. Management by delayed definitive surgery.


Congenital diaphragmatic hernia.

Congenital diaphragmatic hernia.


Osmotic diuretics. The effect on renal histological changes in experimental burns.


Rupture of the bronchus.

Rupture of the bronchus.


Intercarpal arthrodesis.

Intercarpal arthrodesis.


Combined stab wounds of the aorta and vena cava of the abdomen.


Giant lipoma of the thigh.

Giant lipoma of the thigh.


Enzyme molecular heterogeneity (isoenzymes) in surgical diagnosis.


Surgical thyroid disease in northern Thailand. A study in geographic pathology.


Arterial embolism. Surgical treatment and results.


Management of abdominal stab wounds. Roentgenographic technique for diagnosis of peritoneal penetration.


Augmentation of arterial collateral blood flow.


Physical factors in electrocoaptation of blood vessels.


Hyperplastic cholecystosis--segmental adenomyomatosis type. Report of two cases.


Epidermoid cyst of the spleen with rupture and inflammation.


Immediate surgery for cardiac and great vessel wounds.


A comparative study of naturally occurring canine achalasia.


Abdominal pain and the appendices epiploicae.


Surgery of the staghorn calculus. British Association of Urological Surgeons Prize Essay.


The role of disturbed pressure gradients in recurrent urinary infection.


Urinary enzymes in benign and malignant urinary tract disorders: alkaline phosphatase and lactic acid dehydrogenase.


A method of producing experimental uraemia in the rabbit with some observations on the influence of uraemia on peritoneal healing.


Surgical reconstruction of the external genitalia in female pseudohermaphrodites.


Adenocarcinoma of the ureter secondary to ureteritis cystica.


Retropubic dissecting forceps.

Retropubic dissecting forceps.


Automated potentiometric determination of inorganic blood constituents (Na+, K+, H+, Cl).


Kinetic parameters of continuous flow analysis.


Effects of tomatine on the colorimetric determination of cholesterol by the Zak procedure.


Hippuric acid analysis of urine using the Hofmann rearrangement.


The Reitman-Frankel colorimetric transaminase procedure in suspected myocardial infarction.


A rapid spectrophotometric method for the determination of citric acid in blood.


Methanolysis of the intervertebral disc.


An automated method for the determination of serum calcium with glyoxal bis (2-hydroxyanil).


Purification of a cytotoxic serum factor from thyroglobulin-sensitized guinea-pigs.


Synthetic antigens composed exclusively of L- or D-amino acids. I. Effect of optical configuration on the immunogenicity of synthetic polypeptides in mice.


Immunogenicity of heterologous Fc and Fab immunoglobulin fragments in rabbits, guinea-pigs and rats.


Production of hapten-specific unresponsiveness in adult guinea-pigs by prior injection of monovalent conjugates.


Purification and some properties of valyl ribonucleic acid synthetase from yeast.


Molecular sieve studies of interacting protein systems. I. Equations for transport of associating systems.


Rabbit serum monoamine oxidase. II. Determinants of substrate specificity.


Incorporation of glyceraldehyde into the pyridine ring of nicotine.


Purification and properties of porcine gastricsin.


Regulation of cobamide-dependent ribonucleotide reductase by allosteric effectors and divalent cations.


Spectrophotometric studies of copper (II) complexes of glycylglycine.


Biosythesis of the peptidoglycan of bacterial cell walls. II. Phospholipid carriers in the reaction sequence.


Biosynthesis of the peptidoglycan of bacterial cell walls. IV. Incorporation of glycine in Micrococcus lysodeikticus.


Biosynthesis of the peptidoglycan of bacterial cell walls. V. Separation of protein and lipid components of the particulate enzyme from Micrococcus lysodeikticus and purification of the endogenous lipid acceptors.


The optical rotatory dispersion and circular dichroism of calf lens alpha-crystallin.


Inhibitors of protein biosynthesis. II. Mode of action of anisomycin.


Adenosine triphosphate conservation in metabolic regulation. Rat liver citrate cleavage enzyme.


Abdominal aortic aneurysm. A critical clinical reappraisal.


The importance of proper caliber of lumen in femoral popliteal arterial reconstruction.


Effects of castration and of progesterone implantation on muscle composition in the ferret.


Hemodynamic arteriosclerosis.

Hemodynamic arteriosclerosis.


Body weight and food consumption of lactating rats: effects of ovariectomy and of arrest and resumption of suckling.


Distribution of hydroxysteroid dehydrogenases in the placentae and foetal membranes of various mammals.


Arteriography of the breast by one contrast injection.


Anti-shock action of hyperbaric oxygenation.


Radiologic examination in head and neck localizations of arterio-venous fistulae and congenital aneurysms.


Growth and obesity in male rats after placement of ventromedial hypothalamic lesions at four different ages.


Surgical correction of ventricular septal defects. Classification and analysis of 151 patients.


Glutamic-pyruvic transaminase and gluconeogenesis in liver slices: a comparison of the effects of cortisol injection with treatment in vitro.


Coxsackie B-3 virus infection in the pregnant mouse.


Experimental cholera in the rabbit intestinal loop: fluid accumulation and sodium pump inhibition.


Reaction of rabbit leukocytes to staphylococcal alpha hemolysin in vivo.


Gastrointestinal absorption of tetanus toxin in the fetal and newborn rat and rabbit.


The significance of the radiological examination in evaluating the results of surgical treatment of atrial septal defects.


Terms, definitions, and symbols in reflectometry.


Lambert diffuse reflection from general quadric surfaces.


Arteriovenous fistula following nephrectomy.


Depolarization of linearly polarized EM waves backscattered from rough metals and inhomogeneous dielectrics.


Formulas for using wave plates in ellipsometry.


Long term results of epicardial pacing for Stokes Adams attacks in twelve cases.


Pseudoaneurysm of the heart following cardiotomy for total correction of tetralogy of Fallot.


Absorption of low-energy photons in the transition metals.


Interpretation of the infrared optical constants of metals. II.


Reflectance and transmittance of evaporated aluminum and aluminum: magnesium fluoride films in the ultraviolet (-1800A).


Optical properties of insulators in the extreme ultraviolet.


Film-grain noise in wavefront-reconstruction imaging.


Low-intensity reciprocity failure of a AgBr emulsion: effect of halogen acceptors.


Carbon arc in a controlled atmosphere as a radiation standard.


Optical aberration coefficients. 13. Theory of reversible semi-symmetric systems.


Radiative lifetimes of some n=4 and n=5 states in HeII.


Newly identified lines of Ni 18, Cu XIX, and Zn XX in the Na I isoelectronic sequence.


Optimization of the MacAdam-modified 1965 Friele color-difference formula.


Work-function estimation with a single yield measurement.


Optical constants of sapphire in the far infrared.


Formula for calculating the refractive index of a thin transparent plate from polarization-state transmission measurements.


Polarizing holography.

Polarizing holography.


Application of the convolution theorem to Rayleigh's integral formulas.


Superachromatic lens design.

Superachromatic lens design.


Comments on "excitation of waveguide modes in retinal receptors".


Nuclear spin of 249Bk from the hyperfine structure in its emission spectrum.


Normal-incidence reflectance of aluminum films in the wavelength region 800-2000 A.


Infertility in mice caused by fasting at about the time of mating. 3. Pathogenesis.


Maternal behaviour in the rat: some parameters affecting the acceptance of young delivered by caesarian section.


Protein content of the mouse embryo during the first five days of development.


Studies of effects of t-alleles in the house mouse on spermatozoa. I. Male sterility effects.


Early embryonic death and subsequent cycle length in the ewe.


Revascularization of the posterior myocardium by means of a free graft of internal mammary artery.


Intramural coronary artery aneurysm. A coronary artery steal syndrome.


Traumatic arteriovenous fistula of the chest wall and lung. Secondary to insertion of an intercostal catheter.


Systemic-pulmonary arteriovenous fistula of the chest wall and lung. A report of a case and review of the literature.


Retrograde lung scanning. Its contribution to the study of collateral systemic flow to the lung.


Traumatic communication between the aorta, right atrium, and left atrium. A case report.


Myocardial perforation from a permanent endocardial electrode.


Homotransplantation of the mitral valve in dogs treated with azathioprine.


Contribution to the in vitro testing of pumps for extracorporeal circulation.


Hemodynamic studies in experimental ventricular alternans.


Bronchoscopy and esophagoscopy under neuroleptanalgesia with droperidol-fentanyl.


Aortic arch interruption: treatment with pulmonary artery banding.


Systemic embolization after aortic valve replacement.


Cardiovascular responses to acute hemopericardium, compression by balloon tamponade, and acute coronary artery occlusion.


Hemorrhagic pleural effusion secondary to aortography. A case report.


An evaluation of function and failure of artificial cardiac pacemakers. A report of a 5-year experience with implanted cardiac pacemakers and a technique for diagnosing and correcting the cause of pacing failure.


A method to prevent torsion of arterial prosthetic grafts.


The cause and treatment of pulmonary edema after the Mustard operation for correction of complete transposition of the great vessels.


2000 A.D.--prognosis.

2000 A.D.--prognosis.


Bowel habit after gastric surgery.

Bowel habit after gastric surgery.


Atrial fibrillation in acute myocardial infarction.


A comparison of computer and planimetry cardiac output determinations.


The determination of serum and urinary calcium levels with the use of "hydroxy naphthol blue" as complexometric indicator.


A source of Pseudomonas pyocyanea in hospitals and its elimination.


A reverse correlation between the sex ratio of live births and the death rate from malignant neoplasms.


A presentation of a case of hydatid disease.


Presymptomatic diagnosis.

Presymptomatic diagnosis.


Fatal Candida albicans bronchopneumonia.


Why the kissing ought to stop.

Why the kissing ought to stop.


Symposium. Manipulative treatment.

Symposium. Manipulative treatment.


Recovery from radiation injury in swine as evaluated by the split-dose technique.


Macromolecular synthesis and delayed mitotic death due to radiation and drugs in Chlamydomonas and Chlorella.


The isolation of ultraviolet sensitive mutants from Aspergillus rugulosus.


Studies on spleen oxygen tension and radioprotection in mice with hypoxia, serotonin, and p-aminopropiophenone.


Lack of x-ray-induced lethal sectoring in haploid Saccharomyces.


Effect of gamma irradiation on the enzymatic activity of actomyosin--its possible mechanisms.


X-irradiation of defined areas of the heads of weanling rats: effect on body growth and incisor development.


Histologic effects of total-body x-irradiation in various dose fractionation patterns on fetal cerebral hemisphere.


Effect of gamma radiation on the prepuberal bovine ovary.


Radiation and whole light effects on molluscan nerve cells in vitro.


Temperature dependence and effect of glycerol on the radiation sensitivity of bacteriophage-Escherichia coli complexes related to direct and indirect radiation effect.


On the formation of amino acids by gamma-ray-induced carboxylation of amines in aqueous solutions.


Influence of DTPA therapy on long-term effects of retained monomeric plutonium: comparison with polymeric plutonium.


Insulin and epinephrine.

Insulin and epinephrine.


Vascular complications after arterial catheterization and puncture.


Mucoviscidosis (cystic fibrosis of the pancreas) in Bantu twin neonates.


The social status of the African diabetic.


The toxicological aspects of petroleum distillates.


Retirement planning.

Retirement planning.


Getting the most from a conference.

Getting the most from a conference.


New hope for accident victims.

New hope for accident victims.


The grace of excellence.

The grace of excellence.


The management of industrial safety.

The management of industrial safety.


Tissue-cavitary difference pressure of dog left ventricle.


Tissue-cavitary difference pressure of dog myocardium under stress.


Influence of existing arterial pressure on autonomic drug responses.


Effects of changes of pH and of carbon dioxide tension on left ventricular performance.


Blood filtration and its effect on glucose metabolism by the isolated dog brain.


Controlled perfusion pressure and vascular volume changes in dog forelimbs.


Effect of adrenergic blockade on cardiovascular responses to increased airway pressure.


Effects of subendocardial injury on the electrocardiogram of intact dogs.


Effect of sinoaortic denervation on cardiac output.


Configuration of intestinal slow waves obtained by monopolar recording techniques.


Active transport of L-selenomethionine in the intestine.


Changes in membrane properties with hyperpolarization in snail neurons.


Transport of basic amino acids by hamster intestine.


Effect of chronic cardiac denervation on renal response to saline infusion.


Specificity of transport of neutral and basic amino acids in rat kidney.


Active chloride transport in the isolated toad bladder.


Autoradiographic localization of radioiodide in the thyroid gland of the mouse.


Quantitative studies on the olfactory potentials of Lucilia sericata.


Effect of cold on glucose metabolism of fasted and fasted-refed rats.


Hypothalamic stimulation and gastric secretion in the dog.


Metabolism of glucose by C57BL-6 mice.

Metabolism of glucose by C57BL-6 mice.


Concentration and composition of fatty acids of thoracic duct lymph lipids from rabbits.


Myocardial metabolism of free fatty acids in control, hyperthyroid, and hypothyroid dogs.


Lipogenesis in the pigeon: in vivo studies.


Thyrotrophin in rat and human serum after withdrawal of carbimazole.


Fatty acid composition and metabolic activity of depot fat in experimental obesity.


Electrical activity of single vascular smooth muscle fibers.


Plasma levels of corticosterone in methylandrostenediol-salt-induced hypertension.


Transfer of urine into the rumen of goats by a transplanted ureter.


Electrical properties of intestinal muscle as measured intracellularly and extracellularly.


Role of calcium in the plasticity of venous smooth muscle.


Effect of cross innervation on biochemical characteristics of skeletal muscles.


Factor VII survival and turnover in dogs.


Effect of endotoxin on iron absorption.

Effect of endotoxin on iron absorption.


Respiratory grouping of abdominal sympathetic activity in the dog.


O2 deficit incurred during hypoxia and its relation to lactate and excess lactate.


Action potentials in the sensory vagus at the time of coronary infarction.


Effect of capillary pressure and plasma protein on development of pulmonary edema.


Perfusion of cat brain with simplified blood after filtration through glass wool.


Permeability of rabbit heart capillaries to nonelectrolytes.


A new factor in pathogenesis of edema of cardiac origin.


Hypokalemia in the hypertensive patient, with observations on the incidence of primary aldosteronism.


Glucagon provocative test for pheochromocytoma.


Azotemia and glucose intolerance.

Azotemia and glucose intolerance.


Cephaloridine and penicillin G in the treatment of pneumococcal pneumonia. A comparative study.


Hemangioma of the small intestine causing protein-losing enteropathy.


Severe symptomatic hyperkalemia in an adrenalectomized woman due to enhanced mineralocorticoid requirement.


Central venous pressure as a guide to volume expansion.


Smallpox alert.

Smallpox alert.


Dental anesthesia.

Dental anesthesia.


Serum lactate dehydrogenase and pulmonary embolism.


The influence of cardiac output on arterial oxygenation: a theoretical study.


The effect of chlordiazepoxide and pethidine, alone and in combination, on the respiratory response to carbon dioxide.


Experiments demonstrating the uptake, distribution and elimination of nitrous oxide in the context of out-patient anaesthesia. I. Rebreathing experiments.


Serum potassium changes during induction of anaesthesia.


An analysis of the radiological visualization of the catheters placed in the epidural space.


Alterations in response to somatic pain associated with anaesthesia. 18. Studies with some opiate antagonists.


Pre-operative anxiety: a study of the incidence and aetiology.


The neuromuscular effects of propanidid.


Relationship between the blood flow and the extracellular  pH of the cerebral cortex.


The use of electrical impedance plethysmography in an automatic cardiac alarm system.


Oxygen consumption during recovery from anaesthesia.


Changes in blood sugar during intravenous anaesthesia with and without surgery.


Mathematics and medicine.

Mathematics and medicine.


Cell proliferation in the regenerating liver of continuously irradiated mice.


Cell survival and radiation damage in growth cartilage.


The risk of bone cancer in man from internally deposited radium.


Gamma-ray dosimetry of internal emitters. 3. Absorbed fractions for low energy gamma rays.


Radiological aspects of intra-uterine blood transfusion.


Spontaneous version coincident with intravenous pyelography.


Anomalies of the bile passages combined with acute gall-bladder perforation.


Further observations of rodent molar radiology.


Effects of contrast medium injection on haemodynamics in cerebral angiography.


Subdural effusion with enlarged middle cranial fossa.


Congenital ureteral valves.

Congenital ureteral valves.


Disappearing gall-stones.

Disappearing gall-stones.


The gastric fundus simulating a suprarenal tumor: a simple method of identification.


A cutter-splicer for angiographic roll film.


Cavity ionisation theory applied to solid state radiation detectors.


The widening scope of radiotherapy.

The widening scope of radiotherapy.


Fatal pulmonary thromboembolism.

Fatal pulmonary thromboembolism.


Banding of the pulmonary artery in infancy: selection of patients and results of main pulmonary artery banding in the treatment of congenital heart disease.


Surgical wound infection by salmonella.

Surgical wound infection by salmonella.


Rehabilitation after myocardial infarction: practical experience with a graded exercise program.


The confederation worm token.

The confederation worm token.


Aerobic microbial growth at low oxygen concentrations. Sterilizable membrane probes were used to study the relation between oxygen concentration and respiration rate in Candida utilis growing on acetate. When the organism was grown in a continuous fermentor at various dissolved oxygen concentrations (0.23 x 10(-6) to 32 x 10(-6)m), with time allowed for full adaptation to each oxygen concentration, the relationship between oxygen concentration and growth rate simulated Michaelis-Menten behavior, giving an apparent K(m) for oxygen of 1.3 x 10(-6)m. When respiration rate was measured at various oxygen concentrations without allowing time for adaptation, it was found that the respiration rate was directly proportional to O(2) concentration at low O(2) concentrations, and independent of O(2) concentration at high O(2) concentrations. Transition from one type of behavior to the other was fairly abrupt. The respiration rate in the presence of excess oxygen depended on the O(2) concentration at which the cells were grown, but the rate at low O(2) concentrations did not. There was evidence that, at low oxygen concentrations, oxygen diffusion through the cell substance limits respiration rate, at least in part.


Ultrastructure of the obligate halophilic bacterium Halobacterium halobium. The fine structure of Halobacterium halobium was studied by means of a modified double-fixation technique. The cell envelope is shown to consist of both a "wall" and a plasma membrane. Some electron-dense strands were seen inside the cytoplasm running parallel to the cell envelope. An unusual organelle (or organelles) appeared inside the cytoplasm in the form of parallel striated strands.


Structure and composition of the cell wall of Neurospora crassa. The structure and composition of the cell walls of hyphae of Neurospora crassa were investigated by electron microscopy, chemical analysis, and X-ray diffraction both before and after progressive enzymatic degradation by snail gut enzymes, chitinase, and trypsin. The wall consists of two phases: randomly disposed skeletal microfibrils of chitin only and an amorphous matrix which contains both beta-glucans and protein. The protein contains a high percentage of the amides of aspartic and glutamic acid but no hydroxy-proline or cysteine. A portion of this protein is a component of or is associated with a system of pores which is embedded in the matrix of the wall. These pores, 40 to 70 A in outside diameter, sometimes branch and seem to provide a three-dimensional network from one side of the wall to the other. They may be a general system of transport across the walls.


Pesticins. 3. Expression of coagulase and mechanism of fibrinolysis. Mutational loss of pesticin I, a bacteriocin-like substance produced by Pasteurella pestis, is known to result in concomitant loss of a coagulase and fibrinolytic factor. No relationship was detected between pesticinogeny and other tested properties either associated with virulence or peculiar to P. pestis. Pesticin I was distinguished from the coagulase and fibrinolytic activities on the basis of anatomical distribution, behavior during gel filtration, and sensitivity to heat. Coagulase and the fibrinolytic factor were not differentiated by these criteria. Spontaneous suppressor mutations causing reversion to pesticinogeny were not detected, nor were such mutants obtained by treatment with ultraviolet light or 2-aminopurine. Attempts to demonstrate a common activator of pesticin I, coagulase, or the fibrinolytic factor in extracts of pesticinogenic cells were not successful. These results are in accord with the hypothesis that at least two structural genes for the three activities reside on a replicon distinct from the chromosome proper. Fibrinolytic activity was significantly reduced in the presence of 0.003 m epsilon-aminocaproic acid and was nonexistent on fibrin films freed from endogenous plasminogen by treatment with heat. Fibrinolytic activity on heated films could be restored by addition of plasma or serum from six mammalian species. Accordingly, the plague fibrinolytic factor, like staphylokinase or urokinase, promotes the conversion of plasminogen to plasmin.


Cell wall changes during the budding process of Paracoccidioides brasiliensis and Blastomyces dermatitidis. The difference between the budding process of Paracoccidioides brasiliensis and Blastomyces dermatitidis is reported herein. A characteristic feature in P. brasiliensis is that the optical density of the cell wall increases at the site where budding begins and at the neck of the dividing cell, whereas B. dermatitidis does not undergo this alteration. The neck which is formed between the mother and daughter cell at the site of division is much wider in B. dermatitidis than in P. brasiliensis. The bud scar in P. brasiliensis appears as a truncated cone, the top of which is covered only by the inner layer of the cell wall; in comparison, in B. dermatitidis the bud scar exhibits a flattened surface covered by the cell wall. Both fungi show an increase in the number of mitochondria and infoldings of the cytoplasmic membrane at the site of separation, which indicates that at this site there is an increase of metabolic activity.


Platelet damaging factor, a fifth activity of staphylococcal alpha-toxin. Crude and purified staphylococcal alpha-toxin were used to demonstrate that the platelet-damaging effect of crude alpha-toxin represents a fifth activity of the alpha-toxin molecule. The homogeneity of the purified toxin employed was demonstrated by ultracentrifugation, Ouchterlony, and immunoelectrophoretic methods. Continuous-flow electrophoretic migration studies demonstrated under a variety of conditions that the platelet-damaging and the alpha-hemolytic activities migrated as a unit. Fractionation studies with the use of Sephadex G-100, carboxymethyl cellulose, and diethylaminoethyl cellulose failed to separate these two activities. Further, when alpha-toxin of demonstrated purity and crude toxin were adjusted to the same hemolytic activity, they possessed the same platelet-damaging activity. In addition, heat-reactivation studies with crude alpha-toxin revealed that the platelet-damaging effect was inactivated and reactivated in parallel with alpha-hemolytic activity. Comparable studies with purified alpha-toxin showed parallel inactivation of both activities at 60 C. Additional heating at 100 C failed to reactivate either activity. Electron micrographs revealed that purified alpha-toxin produced distinct degenerative changes in rabbit platelets. These studies also provided definite evidence that purified alpha-toxin has a damaging effect on human platelets. Monovalent alpha-antisera prevented platelet damage.


Fine structure of Nocardia asteroides grown in a chemically defined medium.


Lytic action of beta-(1-3)-glucanase on yeast cells. Candida utilis, Saccharomyces cerevisiae, S. fragilis, Pichia polymorpha, and Hansenula anomala yeast cells, harvested in the early logarithmic phase, were attacked with purified beta(1-3)-glucanase from Micromonospora chalcea, which resulted in the liberation of protoplasts. The treated cells were observed under the electron microscope before the protoplasts were liberated. Differences in the cell walls of the enzyme-treated and untreated cells were observed. The action of the glucanase was also tested against isolated walls of C. utilis. The enzyme attacked the S. cerevisiae cell wall in a uniform manner. The attack on S. fragilis was located in certain zones of the cell wall, where breakage occurred and through which the protoplast emerged. On the other three yeasts, an intermediate attack was observed, not as definitely located as in S. fragilis, yet less uniformly than in S. cerevisiae.


Ascospore numbers in Metschnikowia.

Ascospore numbers in Metschnikowia.


Production of capsular polysaccharide (hyaluronic acid) by L colonies of group A Streptococci.


Electron microscopic observations of Coxiella burnetii in the guinea pig.


Differentiation of pathogenic and saprophytic letospires. I. Growth at low temperatures. The minimal growth temperature of the pathogenic leptospires is between 13 and 15 C. The saprophytic leptospires have a minimal growth temperature between 5 and 10 C, or approximately 5 C below that of the pathogens. The capability of the saprophytic leptospires to grow at temperatures below those which allow the growth of the pathogenic leptospires provides a simple method of discrimination. With an inoculum yielding approximately 8 x 10(7) cells per ml in the test medium and an incubation temperature of 13 C, the saprophytic leptospires were easily differentiated from the pathogenic leptospires. All 13 saprophytic leptospires tested grew in the 10% rabbit serum medium at 13 C, whereas none of the 20 pathogens grew during the 30-day incubation period.


Effect of glucose on the oxidation of beta-nitropropionic acid by Aspergillus flavus. The rate of oxidation of beta-nitropropionic acid (BNP) to nitrate by replacement cultures of Aspergillus flavus was linear. For each micromole of BNP assimilated, 1 mumole of nitrate was detected. BNP was readily oxidized at pH 3.8, but not at pH 6.8. In the presence of glucose, nitrate was not detected until after all of the glucose had been utilized. The effect of glucose is attributed to its inhibition of BNP uptake and also to its role as an electron donor for a nitrate reductase.


Subcellular sites involved in lipid synthesis in Saccharomyces cerevisiae. When the crude ribosomal fraction of Saccharomyces cerevisiae was separated into "light" and "heavy" fractions, fatty acid synthetase was concentrated in the former, whereas acetyl-Coenzyme A synthetase, fatty acid "desaturase," and squalene oxidocyclase were found in the latter. The "desaturase" sedimented with the ribosomal material and was not solubilized by low concentrations of sodium deoxycholate (DOC). The other two systems found in the "heavy" fraction sedimented with the membranes, but, upon solubilization of the membranes by DOC, these enzyme systems remained as particles.


Cellular sites for the competence-provoking factor of streptococci. Immune globulins against competent cells of group H streptococci, strains Challis and Wicky, inhibited genetic transformation to streptomycin resistance when added to competent cultures. Antibodies against noncompetent cells did not inhibit transformation of competent cells. Strain Challis is spontaneously highly transformable. Strain Wicky is very poorly transformable but can be converted to high transformability with the exocellular competence-provoking factor (CPF) produced by strain Challis. Globulins against noncompetent cells of strain Challis and Wicky also inhibited transformation when added to noncompetent cultures prior to conversion to competence. Antibodies against cells of the related strain Blackburn, however, did not inhibit transformation under any circumstances. It is concluded that, although globulins prepared against competent cells block the deoxyribonucleic acid receptor sites present in these cells, the globulins prepared against noncompetent cells prevent conversion to competence by blocking the access of CPF to specific cellular sites for this factor. Strain Blackburn seems not to contain CPF-receptive sites and is, therefore, nontransformable.


Protein synthesis in a cell-free extract from Staphylococcus aureus. Cell-free Staphylococcus aureus extracts have been prepared which actively incorporate amino acids into protein. The requirements for amino acid incorporation of this preparation were strongly suggestive of de novo protein synthesis, since it showed an absolute requirement for ribosomes, 105,000 x g supernatant fluid, energy source, and magnesium ion. The stability of these extracts was greatly improved by use of dithiothreitol instead of mercaptoethanol as a sulfhydryl protecting reagent. Data were presented to show that the binding of aminoacyl-soluble ribonucleic acid to ribosomes did not require guanosine triphosphate and supernatant enzyme. The major characteristic which distinguishes this system from other cell-free systems is the much higher magnesium concentration required to maintain ribosomes intact and to obtain the maximal incorporation of amino acids. Addition of polyuridylic acid, polyadenylic acid, or polycytidylic acid caused about 60-fold, 30-fold, or 4-fold stimulation of the incorporation of phenylalanine, lysine, or proline, respectively. Studies by density gradient sedimentation indicated that radioactive polyuridylic acid or polyadenylic acid was associated with the monosomes. This complex can actively synthesize polypeptides. On the other hand, the nascent protein synthesized under the direction of endogenous messenger ribonucleic acid was associated with both polysomes and monosomes.


Relationships of x-irradiation to the enhancement of Candida albicans infections. Preirradiation significantly reduced the number of Candida albicans cells required for the ld(50) of experimentally infected mice. The start and extent of recovery of total leukocytes of preirradiated infected mice were proportional to the dose of X rays administered. During 10 days postinfection, heterophils of infected mice preirradiated with 400 R recovered to levels above unirradiated, uninfected controls but did not exceed those of unirradiated, infected animals. On the other hand, the more radiosensitive lymphocytes were depressed greatly, and a limited recovery below normal values was obtained. The lymph to heterophil ratio of uninfected mice irradiated with 400 R recovered to normal values by 11 days postirradiation. However, decreases in the ratio of unirradiated or X-irradiated infected mice showed little recovery. During 6 to 10 days postinfection, a reduction in microhematocrit values after a dose of 400 R alone was not observed when a C. albicans infection was superimposed on X-irradiated mice. This difference was not due to changes in the red blood cell volume which was decreased by 400 R with or without infection, but was attributed to a greater decrease in plasma volume caused by a combination of X irradiation and infection. Reticulocyte counts indicated that recovery from the significant decrease in erythrocyte production caused by 400 R was retarded by a progressive infection. Elevated total serum protein of unirradiated mice at 6 days after infection was attributed to increases in alpha- and beta-globulins. A dose of 400 R limited but did not prevent an increase alpha- and beta-globulins upon subsequent infection. Candida species infection or 400 R or both did not greatly affect the concentration of gamma-globulins. The albumin to globulin ratio of irradiated, infected mice was intermediate between those ratios found after X irradiation or infection.


Inducible glutamate transport in Mycobacteria and its relation to glutamate oxidation. Washed-cell preparations of Mycobacterium tuberculosis strain H37Ra and M. smegmatis 607 grown in Sauton's medium demonstrated a lag in glutamate oxidation. Washed-cell preparations of M. fortuitum and M. phlei oxidized glutamate immediately and in a linear fashion. Glutamate was oxidized without a lag by washed cells of M. tuberculosis H37Ra and M. smegmatis 607 harvested from a modified medium containing glutamate. Chloramphenicol inhibited the oxidation of glutamate by washed cells grown in the absence of glutamate. These findings suggested the induction of either an enzyme system for glutamate oxidation or a glutamate transport system. The activity of glutamic dehydrogenase was not significantly greater in extracts prepared from cells grown with glutamate. However, the initial rate of glutamate uptake by induced cells was three to four times higher than in noninduced cells. The induction of the glutamate transport system in M. tuberculosis H37Ra and M. smegmatis 607 was shown to parallel the induction of glutamate oxidation. After a 60-min lag, the inducible glutamate transport system appeared. Chloramphenicol prevented the induction of glutamate uptake, although the antibiotic had no effect on glutamate uptake by previously induced cells. Some of the properties of this glutamate uptake system are described.


Correlation of tissue mucopolysaccharides with the hair cycle.


Studies of the diffusion of chromium compounds through skin.


Study of a generalized erythema induced by iodides.


An electron microscopic study on pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement.


Role of some biologically active substances in the mechanism of blister formation.


Macromolecular synthesis and secretion in the mouse alimentary tract. Light and electron microscope autoradiographic studies. II. Incorporation and turnover of tritiated glycine in esophageal and forestomach epithelia.


Removal of intact hair papilla and connective tissue sheath by plucking anagen hairs.


Prognosis for severe psychiatric disabilities incurred in naval service.


Early recognition and management of emotional distress in executives.


Air conduction thresholds for high frequencies.


In-plant care of coular injuries.

In-plant care of coular injuries.


The problem of lone atrial fibrillation.


New infant feeding bottles.

New infant feeding bottles.


High blood pressure and thyroid insufficiency--recent developments.


Research and development in Communist China. China continues to be a country of the wooden plow and the bomb.


LBJ at NIH. President offers kind words for basic RESEARCH.


Smoking and health. FCC demands an antidote to cigarette ads.


Molecular biology: drug firm to establish new research center.


Problematical Pleistocene artifact assemblage from Northwestern Spain. Interdisciplinary study of a Paleolithic site at Budiño, Louro Valley (province of Pontevedra), Spain, shows the presence of various tool-making techniques and types of tools in a single undisturbed site complex found in situ within Middle Würm colluvial deposits.


Europium-155 in debris from nuclear weapons. The lithium-drifted germanium detector enables determination of europium-155 on a routine basis in environmental samples contaminated with debris from nuclear weapons. From measurements of europium-155, cesium-144, and strontium-90 in air filters collected between 1961 and 1966, the yield of europium-155 from weapons was estimated at 1400 atoms per 10(6) fissions, which is close to the yield of europium-155 from fast fission of uranium-238.


Autosomal phosphogluconic dehydrogenase polymorphism in the cat (Felis catus L.). Three patterns of 6-phosphogluconic dehydrogenase activity were obtained by starch-gel electrophoresis of blood from domestic cats. Genetic analysis indicates control of these patterns by a pair of alleles at an autosomal locus. Presence of three enzymatically active bands in heterozygotes and of single bands in homozygotes is compatible with at least a dimeric structure for the enzyme.


Aminoaciduria resulting from cycloleucine administration in man. Cycloleucine (1-aminocyclopentanecarboxylic acid) administration in cancer patients resulted in a reversible marked aminoaciduria consisting predominantly of cystine, ornithine, lysine, and arginine, with only minor elevations of other amino acids. Plasma levels of amino acids were essentially unchanged except for slight decreases in ornithine and lysine. This aminoaciduria is most likely due to a blockage by the drug of the renal tubular reabsorption of cystine, ornithine, lysine, and arginine, resulting in an aminoaciduria of the type seen in cystinuria.


Tritiated thymidine: effect of decomposition by self-radiolysis on specificity as a tracer for DNA synthesis. Tritiated thymidine undergoes decomposition by self-radiolysis. As shown by beta liquid-scintillation measurement and by autoradiography, the resultant breakdown products did not label DNA, but entered macromolecules, other than nucleic acid, contained in the cytoplasm. Caution should be exercised in using aged tritiated thymidine solutions.


Morphological changes in human scalp hair roots during deprivation of protein. Human subjects were deprived of protein for 15 days, after which time hair from the scalp of each subject was plucked and examined. Both the bulb and the external root sheath showed morphological changes. This technique may therefore be useful in diagnosing proteincalorie malnutrition.


Heterologous antilymphocyte globulin: studies in vitro. Incubation of dog-lymphocyte cultures with globulin from antiserum to lymphocytes resulted in a greater percentage of transformed cells than incubation with phytohemagglutinin. Viability counts demonstrated that this globulin and phytohemagglutinin had approximately equal degrees of cytotoxicity.


Tribolium castaneum: morphology of "aureate" revealed by the scanning electron microscope. Counts of setae in "aureate" (au), spontaneous autosomal recessive mutation of good penetrance and viability, show that the au gene causes a three-fold increase in setation over the normal in the visible abdominal sternites but not in the membranous wings of the tenebrionid flour beetle Tribolium castaneum. Micrographs taken with the scanning electron microscope demonstrate that the au gene increases setation throughout the body.


Chromosome studies on Marshall Islanders exposed to fallout radiation. Cytogenetic studies of blood lymphocytes of Marshall Islanders, 10 years after their exposure to radiation from fallout in 1954, show chromosome-type aberrations in 23 of 43 exposed persons. Half the aberrations are of the exchange type. An unexpectedly large number of acentric fragments, but no exchange-type aberrations, appear in a few unexposed people on the same island.


Improved in vitro survival of normal, functional spleen cells. An enrichment method for improving the viability of monolayers of normal mouse spleen cells is described. These cells are capable of saving lethally x-irradiated recipient mice from death, presumably by proliferating and differentiating into mature blood cells.


Chlamydomonas reinhardi: heterozygous diploid strains. Zygotes of the unicellular green alga Chlamydomonas reinhardi occasionally divide mitotically to give rise to stable diploid vegetative strains. As well as by their mode of origin, these strains are distinguished from haploids by cell and nuclear size, DNA content per nucleus, and chromosome number. Diploid strains heterozygous for a variety of mutant genes are phenotypically wild type and mating-type minus. Thus these mutant genes are recessive to their wild-type alleles, and the mating-type-minus is dominant over the mating-type-plus allele.


Function of the dorsal motor nucleus of the vagus. The dorsal motor nucleus of the vagus was destroyed in cats. After periods of survival ranging from 9 to 44 days the response of heart, bronchi, esophagus, and duodenum to stimulation of the distal end of the cut cervical vagus was within the normal range or slightly depressed. It is concluded that the dorsal motor nucleus is not a major source of visceromotor fibers.


Streptonigrin: effect on the first meiotic metaphase of the mouse egg. Streptonigrin, an antibiotic and antitumor agent, alters the chromosomes of the mouse ovum during meiosis. Agglutination of bivalents or achromatic gaps and breaks occurred in the larger pairs both in vitro and in vivo. This newly detected cytogenetic effect suggests that such agents can gain access to developing mammalian ova and destroy the normal progress of meiosis.


Reward and learning in the goldfish.

Reward and learning in the goldfish. An experiment with goldfish showed the effects of change in amount of reward that are predicted from reinforcement theory. The performance of animals shifted from small to large reward improved gradually to the level of unshifted large-reward controls, while the performance of animals shifted from large to small reward remained at the large-reward level. The difference between these results and those obtained in analogous experiments with the rat suggests that reward functions differently in the instrumental learning of the two animals.


Evoked potentials: three-dimensional display. Procedures are described for displaying large numbers of evoked potentials. A photographic superposition of average evoked responses, with the concurrent modulation of the brightness of each trace, yields a display having the appearance of a three-dimensional surface formed from hundreds of average responses.


LSD: injection early in pregnancy produces abnormalities in offspring of rats. One of five rats given a single subcutaneous injection of lysergic acid diethylamide (LSD) early in pregnancy appeared to abort early; two delivered stunted stillborn offspring at term, one delivered a littler of seven healthy and one underdeveloped young, and the last one delivered an apparently normal litter. All five matched controls, given saline injections, went to term and delivered healthy litters of 11 to 16 offspring; there were no abortions and no stillbirths. In a replicate experiment, one of five rats given LSD on the 4th day of gestation aborted, two delivered some stillborn offspring, one gave an abnormally small litter of four, and the last one produced an apparently normal litter of ten. All matched controls delivered healthy litters, totaling 66. Some surviving offspring treated with LSD failed to develop as well as control animals. Treatment of five additional rats with LSD late in pregnancy had no obvious effect on the offspring.


Who pays for pollution?

Who pays for pollution?


Insect pests: microbial control.

Insect pests: microbial control.


Immobilizing drugs lethal to swimming mammals.


Paleopathology: meeting ground for many disciplines.


University basic research.

University basic research.


Sialic acid in HeLa cells: effect of hydrocortisone. HeLa S(3) cells grown in the presence of hydrocortisone contain more sialic acid than their corresponding untreated controls. The percentage of the total sialic acid present in the sedimentable fraction obtained from homogenates of cells treated with hydrocortisone is smaller than that of the corresponding fraction of control cells. In addition to N-acetylneuraminic acid, the chromatographic analysis suggests that HeLa S(3) cells probably contain trace amounts of N-glycolylneuraminic acid.


Tubular structures associated with turnip yellow mosaic virus in vivo. Plants infected with a necrotic strain of turnip yellow mosaic virus contain tubes averaging about 80 millimicrons in diameter and attaining 3 microns in length. The main constituent of these tubes is a protein that is related chemically and immunologically to the protein of the virus. The tubes are composed of hexagonally packed hexagonal subunits resembling the hexamer protein subunits of the virus particles and are probably helical in construction.


Specific binding activity of isolated light chains of antibodies. Free light chains isolated from specifically purified antibody have been shown to bind specific hapten. This proves that part of the binding site does exist on the light chain. The light chains were obtained from antibody directed against the 4-azonaphthalene-1-sulfonate group, and the binding of the simple hapten 4-anilinonaphthalene-1-sulfonate was determined by the fluorescence-enhancement technique. Since this hapten undergoes a striking increase in fluorescence on binding to light chains (and also on binding to specific antibody), the presence of small amounts of bound hapten could be determined, even in the presence of the high concentrations of unbound hapten required because of the low binding constant.


Cytoplasmic and chloroplast ribosomes of Chlamydomonas: ultracentrifugal characterization. Ribosomes isolated from the cytoplasmic and chloroplast fractions of Chlamydomonas were characterized in the ultracentrifuge. The cytoplasmic ribosomes belong to the 80S class of ribosomes, and, like animal ribosomes, dissociate to 60, 50, and 40S subunits. However, like the ribosomes of microorganisms, they contain smaller RNA's, 24 and 16S, and require 0.01 mole of magnesium ions per liter for stability. Chloroplast ribosomes are 70S like those of higher plants but are very unstable. A stable 50S subunit has been observed.


Atmospheric transfer of carbon-14: a problem in fungus translocation studies. The carbon-14-labeled carbon dioxide that is released by respiration after glucose labeled with carbon-14 is applied to fungal mycelium can be reabsorbed in highly significant amounts by distant mycelium and agar media in the same petri dishes. Atmospheric transfer of carbon-14 must be considered when using labeled organic compounds to study translocation in fungi.


Collagen-like fragments: excretion in urine of patients with Paget's disease of bone. Patients with Paget's disease of bone excrete, in the urine, polypeptides that have amino acid composition and other properties resembling those of fragments of collagen. The pattern of isotope incorporation in vivo suggests that these fragments are derived from collagen that has been synthesized and rapidly degraded, or that they are rapidly synthesized but not incorporated into tropocollagen molecules.


Inferior olive of the cat: intracellular recording. The action potential evoked from inferior olivary neurons of the cat by orthodromic, antidromic, or intracellular stimulation has a large prolonged depolarization, frequently with several superimposed smaller spikes. The all-or-nothing unitary response appears to be a property of the cell, and the later spikes are not secondary to synaptic excitation by recurrent axon collaterals.


Chemical-cue preferences of inexperienced snakes: comparative aspects. Different species of new-born, previously unfed snakes will respond with tongue flicking and prey-attack behavior to water extracts of the skin substances of various small animals. However, there are clear species differences in the type of extract responded to by previously unfed snakes, even within the same genus. These differences correspond to the normal feeding preferences shown by the various species.


Cellular dynamics.

Cellular dynamics.


Biomacromolecules: views and models.

Biomacromolecules: views and models.


Trans-endotracheal tube suction in the simulated breathing patient.


Effect of halothane anesthesia on rate of canine oxygen consumption.


Anesthesia for thoracic surgery.

Anesthesia for thoracic surgery.


A genetic study of rheumatoid arthritis and rheumatoid factor in Blackfeet and Pima Indians.


Total osmotic activity values for the synovial fluid and arterial plasma of normal humans, normal dogs and patients with joint effusions.


Cyclopropane: effect on catecholamine biotransformation.


Effect of chronic exposure to ultrasonic aerosols on the lung.


Immunologic studies using antigen-coated charcoal: application to rheumatoid factor (RF).


Arterial blood oxygenation during thoracotomy using 70 per cent nitrous oxide in oxygen.


Halothane biotransformation in man: a quantitative study.


The death certificate in rheumatoid arthritis.


The determination of hydrocarbon anesthetics in blood by gas chromatography.


Bone dynamics of rheumatoid arthritis treated with adrenal corticosteroids.


Pernicious anemia and rheumatoid arthritis.


Competition of antigens in adjuvant disease of rats.


Neuromuscular blockade by d-tubocurarine in children.


Methoxyflurane concentrations from the Cyprane inhaler.


Elementary statistics for the anesthesiologist.


Blood O2 content measurement using the O2 electrode.


Multiple general anesthesias, gastro-esophageal reflux and spontaneous esophageal rupture.


The distribution of lung cancer and bronchitis in England and Wales.


A review of 146 cases of carcinoma of the breast operated on between 1930 and 1943.


Obturator nerve block: a simplified approach.


Gastric cancer and diet. A pilot study on dietary habits in two districts differing markedly in respect of mortality from gastric cancer.


Factors affecting pediatric endotracheal tube size: a statistical analysis.


A histopathologic study on the effect of tobacco chewing on the buccal mucosa in Indians and its relationships to cancer.


An unusual cause of laryngeal obstruction.


Isolated neurologic deficit following spinal anesthesia.


Sarcoma of breast.

Sarcoma of breast.


Nucleases, adenosine deaminase, and dehydrogenases in malignant and non-malignant lesions of the female breast.


Effect of intraperitoneal and subcutaneous injection of chondroitin sulphate on the growth of solid Ehrlich ascites tumour.


The disposition of cytotoxic agents after intralymphatic infusion.


Cross-resistance studies on 1,6-dibromo-dideoxy-D-mannitol(DBM)-resistant Yoshida S.C. sarcoma.


Segmental demyelination of peripheral nerves in the presence of malignant tumours.


The induction of skin tumours in mice by neonatal injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) followed by applications of croton oil to the skin.


Further tests for carcinogenesis using newborn mice: 2-naphthylamine, 2-naphthylhydroxylamine, 2-acetylaminofluorene and ethyl methane sulphonate.


Observation of the action of the thymus on the induction of lung tumours by 9,10-dimethyl-1,2-benzanthracene (DMBA) in new-born A mice.


Effects of progesterone on 9,10-dimethyl-1,2-benzanthracene-induced mammary tumours in Sprague-Dawley rats.


In vitro studies on ovarian activity of different high and low tumour strains of mice.


Testing of iron complexes.

Testing of iron complexes.


The tumor-promoting activity of tobacco leaf extract and whole cigarette tar.


The continuous counting of phosphorus-32 from transplanted rat tumours and the effects of radiosensitisers and radioprotective agents.


Phenylketonuria.

Phenylketonuria.


Tinea in hospitals.

Tinea in hospitals.


Chemical treatment of skin cancer.

Chemical treatment of skin cancer.


Dietetic treatment of phenylketonuria: a follow-up study.


Effects of prompt squatting on the systolic murmur in idiopathic hypertrophic obstructive cardiomyopathy.


Reduction of clotting in Scribner shunts by long-term anticoagulation.


Treatment of stress incontinence by maximum perineal electrical stimulation.


Hepatocellular damage with ethacrynic acid.


Hepatitis with biliverdinaemia in association with indomethacin therapy.


Mycobacterium Battey infection resembling tuberculosis.


Prospects for private health insurance.

Prospects for private health insurance.


Fenfluramine.

Fenfluramine.


Radio communication and the emergency department.


Symposium on problems in clinical pharmacology. Introduction.


Smoking and atherosclerosis.

Smoking and atherosclerosis.


Manpower problems in nursing.

Manpower problems in nursing.


New image for the hospital chaplain.

New image for the hospital chaplain.


Inservice education.

Inservice education.


A problem-solving approach.

A problem-solving approach.


Unit-based inservice education.

Unit-based inservice education.


Adolescents in hospital.

Adolescents in hospital.


Seals for patients.

Seals for patients.


The blood volume in post-necrotic cirrhosis of the liver with splenomegaly.


Oxalate formation from glyoxylate in primary hyperoxaluria: studies on liver tissue.


Amylase excretion by the human kidney.

Amylase excretion by the human kidney.


Urea cycle enzymes in the liver of a patient with argininosuccinic aciduria.


The effect on urinary sodium excretion of altering the packed cell volume with albumin solutions without changing the blood volume in the dog.


The effect of muscular paralysis induced by tubocurarine on the duration and sensation of breath-holding.


Individual variation in secretory capacity of gastric acid to stimulation with solid food and with histamine.


The binding of calcium by the plasma proteins in hyperparathyroidism.


Blood flow in human muscles during external pressure or venous stasis.


Effects of saline and mannitol diuresis on the renal concentrating mechanism in dogs: alterations in renal tissue solutes and water.


The calibration of a whole-body radioactivity counter for the measurement of body potassium content in clinical studies.


Clinical studies on whole-body potassium content measured by gamma-ray spectrometry in health and disease.


Impaired renal conservation of chloride and the acid-base changes associated with potassium depletion in the rat.


Circulatory studies in polycythaemia vera at rest and during exercise.


Lack of effect of fatty meals on blood viscosity.


The effect of prolonged administration of aldosterone on sodium and potassium turnover in the rabbit.


Influence of growing Aerobacter aerogenes in a polyamine-enriched medium on the stability of the 70S ribosomes.


Radiosensitivity in relation to the cell cycle and recovery from x-ray sublethal damage in diploid yeast.


Studies on the induction of chromosomal aberrations in human leukocytes by cytosine arabinoside.


Studies on echinoderm phosphagens. 3. Changes in the content of creatine phosphate after stimulation of sperm motility.


Studies on lymphocytes. V. Short in vivo DNA synthesis and generation time of lymphoid cells in the calf thoracic duct after simulated or effective extracorporeal irradiation of circulating blood.


The response to phytohemagglutinin by lymphocytes from the spleen, thymus and bursa of Fabricius of chickens.


The contribution of background electrical activity to the form of averaged evoked potentials in chloralose anesthetized cats.


Responses in the avian midbrain, thalamus and forebrain evoked by click stimuli.


Effects of hormones on the electrical activity of the brain in the rat and rabbit.


Myelinated afferent nerve fibers from the skin of the rabbit ear.


Synaptic plasticity: the effect of the action potential in the postsynaptic neuron.


Interpretation of microelectrode recordings from the dorsal roots of cat.


Studies of parotid saliva and blood in hemodialysis patients.


Thorax resistivity in children and adults.


Multiple-channel pulsed-field magnet driver.


Effect of high oxygen tensions on diffusing capacity for CO and Krogh's K.


Iontophoretic application of drugs.

Iontophoretic application of drugs.


Nonuniform pulmonary diffusing capacity measured by sequential CO uptake and washout.


Seasonal observations on the cardiac rhythm during diving in the Korean ama.


Effects of uneven ventilation-diffusion ratios on pulmonary diffusing capacity in disease.


Stability of airways during reflex bronchoconstriction.


Rigidity of tracheae and bronchi during muscular constriction.


Structural basis for decreased compressibility of constricted tracheae and bronchi.


Oxygen delivery rate of human blood.

Oxygen delivery rate of human blood.


Blood-brain tissue Pco2 relationships and ventilation during rebreathing.


Differential effects of chronic acceleration on skeletal muscles.


Effect of translocation to 3,800 m altitude on glycolysis in mice.


Effects of training at moderate altitude on physical performance capacity.


Sweat sodium excretion in normal women.

Sweat sodium excretion in normal women.


Uptake and release of free fatty acids and other metabolites in the legs of exercising men.


Wild birds as transport hosts of Spirocerca lupi in the Southeastern United States.


Ultrastructural changes in the mouse exocrine pancreas induced by prolonged treatment with actinomycin D.


A fibrous banded structure in a crop lesion of the cockroach, Leucophaea maderae.


X-ray camera assembly for routine microradiography.


Filamentous substructure of microtubules of the marginal bundle of mammalian blood platelets.


Electron microscopy of virus-infected sunflower leaves.


Light and electron microscope studies of smooth endoplasmic reticulum in dividing rat hepatic cells.


Acid-base regulation: classical concepts and modern measurements. A synopsis for physicians.


Renal maintenance of acid-base balance in health.


Stroke among a coal mining population.

Stroke among a coal mining population.


Replacement therapy of the menopause.

Replacement therapy of the menopause.


Radiographic features of the megasigmoid syndrome.


Clinicopathologic conference. Case presentation. (JHH 221236).


Biochemical studies of otosclerosis. Enzymes and protein in normal malleus, incus, and stapes.


Evidence of hepatic disease that may be overlooked.


Colonic and systemic manifestations of chronic ulcerative colitis.


Salmonellosis and shigellosis: epidemiology and clinical features.


Uncommon manifestations of rheumatoid arthritis.


Cervical root syndrome.

Cervical root syndrome.


Unusual manifestations of diffuse obstructive emphysema.


Late manifestations of breast cancer.

Late manifestations of breast cancer.


Extrathoracic manifestations of bronchogenic carcinoma.


Primary aldosteronism. Unusual manifestations and a practical approach to diagnosis.


Unusual manifestations of coronary artery disease.


Manifestations of atrial septal defects.


"Stiff heart" syndrome. An uncommon cause of heart failure.


Essential hypertension.

Essential hypertension.


Encephalopathy and fatty degeneration of the viscera associated with chickenpox.


Analysis of porphyrin methyl esters by thin-layer chromatography and fluorimetric scanning.


Secondary failure to sulphonylureas in the treatment of diabetes.


Treatment of symptomatic porphyria by venesection.


Double aortic arch constricting trachea and oesophagus. Clinical and postmortem features in a patient surviving to 56 years.


Genesis of osteomalacia following gastroenterostomy.


The isozymes of human erythrocyte catalase.


The pathogenesis of varicose veins.

The pathogenesis of varicose veins.


Some aspects of the relationship of salt and hypertension.


The Jeremiah Metzger lecture: what can we do for the patient with renal failure?


Observations on the movement of hydrogen ion, potassium and other electrolytes in forearm exercise.


President's address. The climatology and clinical mores of the voyageurs.


Aortic valve perforation.

Aortic valve perforation.


The second heart sound in pulmonary embolism and pulmonary hypertension.


Ballistocardiograms and ischaemic heart disease. A nine year follow up.


Death in asthmatics.

Death in asthmatics.


Appraisal of typhoid vaccine in experimentally infected human subjects.


Cardiac and pulmonary fibrosis during methysergide therapy for headache.


Early onset myotonic dystrophy. Clinical and laboratory findings in five families and a review of the literature.


The wabbler-lethal mouse. An electron microscopic study of the nervous system.


Electron microscopic observations on human intracranial arteries. Changes seen with aging and atherosclerosis.


The physiologic response to therapy in experimental cerebral ischemia.


The electrophysiological study of myoclonus in man.


Brain extracellular space and the sink action of cerebrospinal fluid. Measurement of rabbit brain extracellular space using sucrose labeled with carbon 14.


Is acetylcholine the trophic neuromuscular transmitter?


Degeneration and regeneration in peripheral nerve.


Studies of spasticity in man. 2. Analysis of stretch reflexes in spasticity.


Studies on demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis. A histological and electrophysiological study. I. Symptomatology and histological observations.


Clinical aspects of spinal neurofibromas.


Medical education. Need for integrated training schemes.


Physical factors in the production of the myelopathy of cervical spondylosis.


Safer dental anaesthesia.

Safer dental anaesthesia.


On perseveration in aphasics.

On perseveration in aphasics.


Memorandum on the management of accidents in childhood. Prepared by the Standing Committee on Accidents in Childhood of the British Paediatric Association.


A year's cancer research.

A year's cancer research.


Prolapse of the posterior leaflet of the mitral valve: a clinical, familial, and cineangiographic study.


Observations on urinary white cell excretion before and after surgery.


Intermittent haemodialysis: insertion and care of the silastic-teflon cannula.


Prevention of urinary infection by means of closed drainage into a sterile plastic bag.


Methaqualone addiction and delirium tremens.


Radioiodine therapy of thyrotoxicosis.

Radioiodine therapy of thyrotoxicosis.


The physician and the clinical biochemistry laboratory.


The inevitability of growing old.

The inevitability of growing old.


Pertinency of an extraneous variable.

Pertinency of an extraneous variable.


The parolee as normal volunteer for clinical research.


A multivariate analysis of the risk of coronary heart disease in Framingham.


The measurement of pattern A behavior.

The measurement of pattern A behavior.


The prevalence of diabetes mellitus and related variables--a population study in Sudbury, Massachusetts.


Cerebral vascular disease in Hiroshima, Japan.


Testosterone-binding levels in the serum of women during the normal menstrual cycle, pregnancy, and the post-partum period.


Anabolic effects in man of papain digests of bovine growth hormone.


Pheochromocytoma and obesity.

Pheochromocytoma and obesity.


Measurement of urinary estrogens using adsorption on Sephadex.


Plasma chromatography of iodinated compounds in cryptothyroidism.


Plasma growth hormone levels in children with cystic fibrosis and short stature. Unresponsiveness to hypoglycemia.


Delay in control of thyrotoxicosis after treatment with radioactive iodine.


Evidence for the presence in human plasma of an estrogen-binding factor other than albumin: abnormal binding of estradiol in men with hepatic cirrhosis.


Cortisol-binding capacity of plasma transcortin: a sex-linked trait?


Spontaneous hypoglycemia associated with an adrenocortical carcinoma.


A method for the measurement of aldosterone in peripheral plasma using 3H-acetic anhydride.


Effect of horse serum and fetal calf serum on stability of chromosomes in mouse embryo cells in vitro.


Morphologic studies of lymphoid tissues during the growth of an isotransplanted mouse tumor.


Birth characteristics of women dying from breast cancer.


Inhibition by methylprednisolone of regression of the Shope rabbit papilloma.


The metabolism of amino acids in developing rat brain.


The in vivo and in vitro synthesis of sulphatides during development.


Preparation and characterization of a glycerogalactolipid fraction from sheep brain.


Penetration of blood-brain barrier by gamma-aminobutyric acid at sites of freezing.


Two fractions of axonal acetylcholinesterase exhibiting different behaviour in severed nerves.


Amines of human whole brain.

Amines of human whole brain.


Lipid composition of human glial tumour and adjacent brain.


Arginine requirement of the young rabbit.


Development of hemolytic anemia in rats fed methionine.


Fate of selenium from selenite or seleno-methionine, with or without vitamin E, in lambs.


Amino acid imbalance and liver glycogen changes in rats fed glycine.


Effect of environmental temperature on fatty livers produced by various hepatotoxic agents in rats.


Recovery of rat tissue lipids from essential fatty acid deficiency: plasma, erythrocytes and liver.


The relationship of Ca and P nutrition during adult life and osteoporosis in aged mice.


Aspects of mineral nutrition of the pea aphid, Acyrthosiphon pisum (Harris).


Maintenance of pregnancy in protein-deprived rats by transitory protein supplements during early gestation.


Evaluation of polyethylene, chromic oxide, and cerium-144 as digestibility indicators in burros.


Effects of dietary iron level on gut iron levels and iron absorption in the rat.


Absorption, excretion, and retention of orally administered zinc-65 in various tissues of zinc-deficient and normal goats and calves.


Influence of controlled temperatures on growth rate and plasma ascorbic acid values in swine.


Urine flow and renal metabolism following prolonged complete ureteral occlusion.