Quantitative and qualitative aspects of photoreactivation of premutational ultraviolet damage at the ad-3 loci of Neurospora crassa.


Forward mutation studies with N-nitroso-N-methyl-urethane and N-nitroso-N-ethylurethane in Schizosaccharomyces pombe.


Induction of chromosome- and chromatid-type aberrations by phleomycin.


Comparison of mutagenesis by x-rays and triethylene melamine in Paramecium, with emphasis on the role of mitosis.


Viability of heterozygotes for induced mutations in Drosophila melanogaster. 3. Mutations in spermatogonia.


Induction of paternal sex-chromosome losses and deletions and of autosomal gene mutations by the treatment of mouse post-meiotic germ cells with triethylenemelamine.


Induction of chromosome aberrations in cultured human cells by ethylenimine and its relation to cell cycle.


The induction of mosaic and complete dumpy mutants in Drosophila melanogaster with ethyl methanesulfonate.


Abnormal bile-salt patterns and intestinal bacterial overgrowth associated with malabsorption.


Experimental intracardiac visualization.


Polymyalgia rheumatica and blindness.

Polymyalgia rheumatica and blindness.


Treatment of scoliosis.

Treatment of scoliosis.


Medicine, money and manpower--the challenge to professional education. 3. Increasing personnel.


Lung abscess.

Lung abscess.


Tetanus.

Tetanus.


Arteriovenous fistula after retrograde brachial catheterization.


Diuresis and diuretics.

Diuresis and diuretics.


Pain, pains and patients. 6. Drugs and pain relief: analgesics.


Wycombe General Hospital; Bucks.

Wycombe General Hospital; Bucks.


Pictorial paediatrics. 2. Growth.

Pictorial paediatrics. 2. Growth.


The growing problem of subnormality. 2.

The growing problem of subnormality. 2.


Dame Alicia was right.

Dame Alicia was right.


A district college of nursing.

A district college of nursing.


Integration and the principal nursing officer.


Airless paint gun injuries of the hand: a clinical and experimental study.


Basal cell carcinoma: a statistical approach to rational management.


Intrauterine foetal death with hypofibrinogenemia coagulation. Studies in a case treated with heparin.


Studies on the pathogenesis of tetracycline-induced fatty liver.


The relative effect of an anticholinergic drug, glycopyrrolate, on basal gastric secretion and sweat- and salivary-gland activity.


Determination of the dose of histamine causing maximal gastric acid secretion in the pylorus-ligated rat.


Effect of local gastric trauma on gastric response to histamine stimulation.


Steatorrhea and malignant lymphoma. The relationship of malignant tumors of lymphoid tissue and celiac disease.


Urolithiasis as a complication of chronic diarrheal disease.


Scintigrams in the diagnosis of hepatic neoplasia. Use of colloidal radioactive gold and of 75-selenium-methionine.


Aneurysm of the hepatic artery. An unusual cause of obstructive jaundice.


Quantitative radioisotopic approaches to hepatic size and function.


Recurrent acute pancreatitis associated with systemic lupus erythematosus. Report of a case.


Familial aspects of gastric carcinoma.

Familial aspects of gastric carcinoma.


Intestinal motility in man: the effect of bradykinin on the motility of the distal colon.


Electron microscopy of the human rectal mucosa. A comparison of idiopathic ulcerative colitis with inflammation of known etiologies.


Degree of fluorescence in the prognosis of malignant tumors.


Acid, alkaline, and peptic secretion in chronic gastritis.


The lymphatics of the intestinal mucosa. A clinical and experimental study.


Roentgenographic barium patterns and gastric secretion.


Jejunogastric intussusception: an infrequently recognized cause of postgastrectomy complications.


Functional analysis of intracellular components in kidney.


Certain aspects of the heart as a pump.

Certain aspects of the heart as a pump.


Electronic measurement of blood flow.

Electronic measurement of blood flow.


Factors influencing erythrocyte destruction in artificial organs.


Feedback control analysis of accommodative convergence.


Automated storage and retrieval of patient data.


Biomedical engineering manpower.

Biomedical engineering manpower.


Experiences in the development of a membrane heart-lung machine.


Bioengineering efforts in developing artificial hearts and asistors.


Studies on the biophysics of intravascular thrombosis.


Chronic carotid sinus nerve stimulation in the treatment of essential hypertension.


Studies related to development of an implantable power source for circulatory assist devices.


Implanted cardiac pacemakers. Experience with one hundred consecutive patients.


Energy transport through tissue by inductive coupling.


Effects of higher oxides of nitrogen on the anaesthetized dog.


Abdominal presentation of bronchogenic carcinoma.


Gravitational ulceration.

Gravitational ulceration.


De Quervain's disease--stenosing fibrous tendovaginitis at the radial styloid process.


Exposure to the maternal ovaries resulting from pregnancy radiographs as a function of ovarian location.


Ovarian dysgerminoma.

Ovarian dysgerminoma.


Automation of radiation treatment planning. VI. A general field equation to calculate percent depth dose in the irradiated volume of a cobalt 60 beam.


A new angiographic injection system.

A new angiographic injection system.


A time-marking device for serial radiographs.


A modification of the Talley pump for automatically firing the serial changer and operating a time marking device.


Mechanised film transportation.

Mechanised film transportation.


Carcinoma of thyroid associated with other primary malignant tumors.


Extensive dysplasia and carcinoma in situ of esophageal epithelium.


Myxoma of the toe. Case report.

Myxoma of the toe. Case report.


Prostatic carcinoma presenting as acute obstruction of large bowel.


Cyclophosphamide in the management of Ewing's sarcoma.


Smoking patterns and specialty training of Oregon physicians.


Microglial glioma of brain with extracerebral involvement.


Granular cell ameloblastoma with metastasis to the cervical vertebrae. Observations on the origin of the granular cells.


Effects of participation upon self-evaluation and job satisfaction.


Inguinal hernias and hydroceles in infants and children.


Recent animal contributions to the study of salicylate ototoxicity.


Landry's ascending paralysis in acute intermittent porphyria.


The case of mistaken identity. A cause for marital conflict.


Gastrointestinal copper absorption in man.


Mucosal diaphragm of the gastric antrum.


The alkaline tide.

The alkaline tide.


Do the parietal cells respond in all-or-none manner?


Production of duodenal ulcers in cats by infusion of porcine gastrin.


Secretory rate of gastric acid and pancreatic bicarbonate in the dog after feeding.


In situ pH of duodenal bulb contents in normal and duodenal ulcer subjects.


Reactive and nonreactive aluminum hydroxide gels. Dose-response relationships in vivo.


Maximal acid response to histamine in duodenal ulcer patients subjected to resection of the antrum and duodenal bulb followed by vagotomy.


Correlation of electric surface potentials, intraluminal pressures, and nature of tissue in the gastroesophageal junction of man.


Correlation of jejunal function and morphology in patients with acute and chronic diarrhea in East Pakistan.


Studies of hepatic excretory function. 3. Effect of hypopituitarism on the hepatic excretion of sulfobromophthalein sodium in man.


Mesenteric arterial disease: the present position.


An arteriographic study of mesenteric arterial disease. I. Large vessel changes.


Physical and psychological evaluation of 'non-organic' abdominal pain.


Comparison of the effects of a gastrin extract and a synthetic pentapeptide on gastrointestinal motility in the cat.


An analysis of the autonomic control of gastrointestinal motility in the cat.


Effect of 1-hyoscyamine on gastric secretion of acid and intrinsic factor in man.


Pancreatic function and the absorption of fat, iron, vitamin B12, and calcium after total gastrectomy for gastric cancer.


Clinical course, late results, and pathological nature of inflammatory disease of the colon initially sparing the rectum.


Splenomegaly and renal displacement.

Splenomegaly and renal displacement.


Action of various new analgesic drugs on the human common bile duct.


Myenteric plexus in Hirschsprung's disease.


Technique for the direct injection of materials into the ruminant abomasum.


Hemodynamic changes during sleep.

Hemodynamic changes during sleep.


Intra-articular surgery for degenerative arthritis of the knee. A report of the work of the late K. H. Pridie.


Effects of slow intravenous endotoxin infusion on hemodynamics and survival in dogs.


The genetics of orthopaedic conditions.

The genetics of orthopaedic conditions.


Unilateral facet interlocking in the lower cervical spine.


Results of treatment of 100 congenitally dislocated hips.


Excision of calcaneo-navicular bar for painful spasmodic flat foot.


Ischaemia complicating closed tibial and fibular shaft fractures.


Unreduced anterior dislocation of the hip. Report of seven cases.


Unrecognised dislocation of the hip in fractures of the femoral shaft.


Venous drainage in osteoarthritis of the hip. A study after osteotomy.


Dislocation of the extensor tendons of the hand. Report of a case.


An operation frame for spinal fusion. A new apparatus designed to reduce haemorrhage during operation.


Some observations on the effects of blood and a fibrinolytic enzyme on articular cartilage in the rabbit.


The dual nature of epiphysial cartilage.


The anatomy of the volar part of the capsules of the finger joints.


Determination of simultaneous effective renal plasma flow and glomerular filtration rate with 131-I-ortho-iodohippurate and 125-I-allyl inulin.


Pseudodiploid chromosomal pattern in chronic lymphocytic leukemia.


Cognitive process and conversion reactions.


Mechanisms of action of diazoxide.

Mechanisms of action of diazoxide.


Stability of earliest memories under LSD-25 and placebo.


Representation of the laboratory setting in dreams.


Television: technical and artistic aspects of videotape in psychiatric teaching.


Suicide in war veterans: rates and methods.


Radical operation under hypothermia for ventricular septal defect in infancy. A report of 67 consecutive cases.


Effect of reserpine and chlorpromazine on some cold stress-induced biochemical alterations.


Alteration of the plasma disappearance and biliary excretion patterns of exogenously administered bilirubin by alpha-nephthylisothiocyanate.


Esophageal stricture at anastomotic site following repair of tracheoesophageal fistula. A nineteen-year follow-up.


Decompression in percussion concussion: effects on "concussive response" in rabbits.


Associated injuries in head injured patients.


Thoracic injuries due to blunt trauma.

Thoracic injuries due to blunt trauma.


Intramedullary fixation for fractures of the femoral shaft. A study of complications in 298 operations.


Osteotomy of the clavicle in surgical reduction of anterior sternoclavicular dislocation.


Blind nailing of the femur. A technique for closed intramedullary nailing of the femur using polaroid radiography.


Technical considerations in the management of axillobrachial arterial injuries.


Pain, pains and patients. 5. "That Caesar is more dangerous".


Experiments of nature involving branch-chain amino acids.


Hyperglycinemia with ketoacidosis and leukopenia. Metabolic studies on the nature of the defect.


Galactose metabolism in the newborn infant.


Studies on intestinal digestion of starch in man. II. Intestinal hydrolysis of amylopectin in infants and children.


Renal localization for percutaneous biopsy by scanning with technetium-99m-iron complex.


Effect of sedation on oxygen consumption of children undergoing cardiac catheterization.


Some aspects of cardiac pathology in infancy and childhood. IV. Myocardial and coronary lesions in cardiac malformations.


American Academy of Pediatrics. Committee on fetus and newborn. Nomenclature for duration of gestation, birth weight and intra-uterine growth.


Pediatric consultation in a public mental hospital.


Nomenclature, duration of gestation, birth weight, intrauterine growth. Dissenting views.


Meningeal branches of the ophthalmic artery.


Effects of furniture polish on pulmonary surfactant.


Comparison of endogenous creatinine clearance with inulin clearance.


Neomycin-resistant Staphylococci in a rural outpatient population.


Dermatoglyphics in idiopathic mental retardation.


Radiological case of the month.

Radiological case of the month.


Congenital atresia of the subclavian artery producing the "subclavian steal syndrome".


Acute alcohol withdrawal syndrome in a newborn.


Reversible secondary disaccharidase deficiency.


Spondylo-epiphyseal dysplasia (pseudoachondroplastic type). Case report with pathologic and metabolic investigations.


Pseudotumor cerebri in congenital adrenal hyperplasia.


Adrenocortical carcinoma with virilism in an infant under 1 year of age.


On the use of computers in human genetics: an introduction.


Megaloblastic anemia and orotic aciduria. A hereditary disorder of pyrimidine metabolism responsive to uridine.


Some genetic programs to supplement self-instruction in FORTRAN.


Simulation of genetic systems. XI. Inversion polymorphism.


Monte Carlo methods in human population genetics: a computer model incorporating age-specific birth and death rates.


Phylogenetic analysis. Models and estimation procedures.


Testing of single locus hypotheses where there is incomplete separation of the phenotypes.


Record linking: the design of efficient systems for linking records into individual and family histories.


Specific and nonspecific passive desensitization 8. Comparison of nonspecific passive desensitizing capacities of heterologous and homologous normal sera.


Respiratory allergy and the regional climate in Israel.


Fungus extracts: remarks on concentrations used in testing.


Observations on dynamics of microcirculation during experimental anaphylaxis.


Radioimmunoelectrophoretic studies of antigen binding capacity of atopic sera.


Symposium on limb ablation and limb replacement. Closing remarks.


Atopic dermatitis and congenital defects, disease, and mortality.


Isokinetic contraction: a new concept of resistive exercise.


Volume changes in indentation tonometry.


Vascular abnormalities in disciform degeneration of the macula lutea demonstrated with fluorescein.


Fibromyxosarcoma of the eyelid.

Fibromyxosarcoma of the eyelid.


Invasion of the orbit by maggots.

Invasion of the orbit by maggots.


A sterile disposable cryoextractor (cryophake).


A SIMPLE CRYOSURGICAL INSTRUMENT AND ITS APPLICATION IN Ethiopia.


New iris retractor for use in cryosurgery.


Functional characteristics of neurons in the lateral reticular nucleus with reference to localized cerebellar potentials.


Toxicity of cadmium for the central nervous system.


Septotectal projections in the cat.

Septotectal projections in the cat.


A trigeminal monosynaptic reflex in birds.


Interaction of cortical and peripheral inputs to polysensory areas of the cat neocortex.


Mechanism of demyelination in allergic encephalomyelitis of guinea pigs. An electron microscopic study.


Extracellular space of normal peripheral nerve and normal skin as measured by radioactive sulfate in the chicken.


Reaction of different parts of the cerebral vascular system in asphyxia.


A study of cardiac output at rest throughout pregnancy.


Some impressions of childbearing in tropical areas.


The XY female.

The XY female.


Cul-de-sac puncture in the diagnosis of early ovarian carcinoma.


Eclampsia 1963-1966. Evaluation of the treatment of 107 cases.


Prospective bacteriological studies in inflammation of the placenta, cord and membranes.


Oxytocin blood levels in two cases of diabetes insipidus.


The histological changes produced in untreated adeno-carcinoma of the endometrium by a progestogen.


The value of enzyme histochemical studies in the histological and cytological diagnosis of uterine cervical lesions.


Ascites in a case of twin pregnancy.

Ascites in a case of twin pregnancy.


Eclampsia in molar pregnancy.

Eclampsia in molar pregnancy.


Bowel anastomosis by inverting and everting techniques. An experimental study.


Partial and total diversion of inferior vena cava into left atrium to produce chronic cyanosis in dogs.


Suppression of rat mammary cancer with estradiol in relation to later tumor response to oophorectomy.


Bidirectional movement of water through the skin of a nonsweating animal.


Ox liver catalase crystal structure by electron microscopy.


The productivity of prostatic needle biopsy in the recognition of early prostatic cancer.


Heart disease following radiation.

Heart disease following radiation.


Clinical features of extracutaneous sporotrichosis.


Estimation of beta-glucuronidase activity in urinary-tract infection.


Valve replacement in active bacterial endocarditis.


Medicine, money and manpower--the challenge to professional education. IV. New training for new needs.


Hemolytic transfusion reactions associated with the Kidd antibody (JkA).


By the London Post. On occupational hazards, medical resources--personal postscript and forward planning.


Case records of the Massachusetts General Hospital. Case 27-1967.


A raid on the inarticulate.

A raid on the inarticulate.


Problems of the admission of patients.

Problems of the admission of patients.


Patients' views of a psychiatric hospital.


Nursing administration.

Nursing administration.


Nursing administration--changing patterns.


Surgical repair after pharyngolaryngectomy.


Management techniques.

Management techniques.


Nerve regeneration: correlation of electrical, histological, and behavioral events. Wihtin 5 days after the leg nerves of a cockroach are injured, miniature end-plate potentials have disappeared. and the muscle is unresponsive to electrical stimulation. The soma of the injured neutron has a dense perinuclear ring of RNA. By 40 days after the injury, locomotor activity has returned, and the miniature end-plate potentials and evoked electrical responses have reappeared in the muscle. The RNA ring has disappeared, and the nucleus of the regenerating neuron has shifted to an eccentric position.


Retirement crisis.

Retirement crisis.


The administration of federal aid: a monstrosity has been created.


Romeriscus, the oldest known reptile.

Romeriscus, the oldest known reptile. The description of Romeriscus, a new genus of limnoscelid reptile, is based on a partial skeleton from the Early Pennsylvanian (Westphalian A) of Nova Scotia. Although it is the earliest and most primitive reptile yet known, it is probably already too late and too specialized to be ancestral to the more advanced Carboniferous and Permian captorhinomorphs and pelycosaurs.


Hemoglobin Portland 1: a new human hemoglobin unique in structure. A new hemoglobin (Hb), Portland 1, has been found in a newborn infant having multiple congenital anomalies and complex autosomal chromosomal mosaicism. The new hemoglobin has a unique tetrameric structure (molecular weight, 66,000) composed of two pairs of different types of chains, neither of which is alpha, gamma(2)x(2). The x-chain of Hb Portland 1 may be a new type of hemoglobin chain, but the available evidence suggests that it may be identical with the epsilon chain. We suggest that Hb Portland 1 is an embryonic hemoglobin that persisted until after birth in relatively large amounts in this patient.


Reformation of functional liver polyribosomes from ribosome monomers in the absence of RNA synthesis. The administration to rats of the ethyl analog of methionine, ethionine, results in the rapid decrease in the hepatic concentration of adenosine triphosphate followed by an extensive disaggregation of polysomes to ribosome monomers and a concomitant inhibition of protein synthesis. These effects are readily reversed by the injection of methionine or precursors of adenine nucleotides such as adenine. The reformation of liver polyribosomes in such animals following the administration of adenine plus methionine was found to occur under conditions in which new RNA synthesis was markedly inhibited. Free messenger RNA without attached ribosomes must be capable of remaining functionally active in the liver cytoplasm for many hours.


Hematuria following administration of ethanol. Hematuria, with some erythrocytes also appearing in the urine, was observed in male albino rats given 20 percent and 40 percent ethanol in lieu of drinking water for several weeks. However, the amounts of hemoglobin in the blood of the treated group did not change relative to those of the control group; this finding indicates that the degree of hematuria was not sufficient to produce an anemia.


Benzpyrene hydroxylase induction by polycyclic hydrocarbons in hamster embryonic cells grown in vitro. Treatment of hamster embryonic cells with 1,2-benzanthracene for 4 to 48 hours induced a three- to tenfold increase in the activity of benzpyrene hydroxylase. That the increase in enzyme activity was completely prevented by puromycin suggested an induction of enzyme synthesis.


Enzymatic identification of fish products. Comparative enzymological techniques were used to distinguish between the muscle lactate dehydrogenases of 26 fish species. Intergeneric differences in enzymatic properties were frequently encountered. The techniques revealed, in addition, that some commercial samples of frozen fish fillets, labeled "haddock," contained cod lactate dehydrogenase.


Carbon-14 and tritium measurement by means of bremsstrahlung emissions. The feasibility of measuring carbon-14 and tritium in vivo has been demonstrated in the rat; thin scintillation detectors were used for the measurement of bremsstrahlung produced by these soft beta emitters. Measurements of tritium in vivo are limited to the study of surface phenomena, whereas bremsstrahlung produced by carbon-14 may be detected from depths of several centimeters.


Cocoon surrounding desert-dwelling frogs. A cocoon formed from a single cell layer of shed stratum corneum may reduce water loss from the skin of desert-dwelling frogs while these aestivate in soil-filled burrows. In several Australian examples, the cocoon is a single layer of cells, and thus differs from the multilayered structure obtained from an American species, Scaphiopus couchi.


Sex attractant of the black carpet beetle. The principal component of the sex attractant of the black carpet beetle Attagenus megatoma (Fabricius) is trans-3, cis-5-tetradecadienoic acid.


Frequency sensitivity of single auditory neurons in the gecko Coleonyx variegatus. Although acoustic communication is not pronounced in reptiles, analysis of single auditory neurons in the medulla oblongata shows that the cochlea is a frequency analyser. Auditory neurons of the lizard Coleonyx variegatus respond to acoustic stimuli over a range of less than 0.1 to 17 kilohertz and are maximally responsive between 0.8 and 2.0 kilohertz. The frequencies to which they are most sensitive differ from neuron to neuron, ranging from 0.11 to 4 kilohertz. Some neurons have an inhibitory area which greatly overlaps the response area, so that inhibitory areas do not seem to sharply tune the response area at this level of the auditory tract. The inhibitory area is responsible for producing in some neurons a phasic response and nonmonotonic relation between sound intensity and number of impulses. The response pattern shows a tendency to change from tonic to phasic in more advanced auditory centers. This may serve to code rapid changes in the acoustic stimuli.


Receptive fields in the cat retina: a new type. A new type of receptive field of cat retinal ganglion cells is described and termed the "suppressed-by-contrast" type. The firing rate of these cells is suppressed by a variety of visual stimuli. However, it has not been possible to find a stimulus that increases the firing rate above the maintained level.


The (+) reference: accuracy of estimated mean components in average response studies. The (+/-) reference is defined as the result of alternate addition and subtraction and division by N (the number of sample functions). Under suitable conditions both the (+/-) reference and the variable component (noise) of the usual average tend to be derived from the same Gaussian process, and the former can be used as a measure of the latter. This property is most easily applied when the noise is derived from a stationary process. Application of the (+/-) reference and the average of the square of the voltage in studies of evoked response is discussed.


Animals at very high pressures of helium and neon. At pressures up to 125 atmospheres, helium failed to anesthetize mice; at slightly higher pressures (135 to 145 atmospheres) it proved lethal. With Italian newts (Triturus italicus), whose sensitivity to anesthesia by nitrogen is similar to that of mice, responsiveness was lost at pressures between 165 and 245 atmospheres, whether the pressure was achieved with helium or neon, or hydrostatically. It was concluded that the anesthetic pressures of helium and neon, for mice and newts, are higher than the tolerable mechanical pressures.


Seal ears.

Seal ears.


An evaluation of antibiotics in biliary tract surgery.


Splenectomy for agnogenic myeloid metaplasia.


The reversal by cartilage of the steroid-induced inhibition of wound healing.


An improved ileocolostomy.

An improved ileocolostomy.


Pulmonary embolism in unanesthetized dogs.


An analysis of the complications of the radiologic treatment of carcinoma of the cervix.


Intestinal fluid loss in dogs during irreversible hemorrhagic shock.


Sympathectomy in iliofemoral venous thrombosis.


Myxomas of the pelvis.

Myxomas of the pelvis.


Traumatic diaphragmatic hernia.

Traumatic diaphragmatic hernia.


A study of 605 fatal pulmonary embolisms and two successful embolectomies.


Susceptibility of Mycoplasma pneumoniae to 21 antibiotics in vitro.


The ecology of histoplasmosis.

The ecology of histoplasmosis.


Inappropriate antidiuretic hormone secretion and myxedema: hazards in management.


Diabetes mellitus among Navajo and Hopi indians: the lack of vascular complications.


Meprobamate poisoning: successful treatment with peritoneal dialysis.


Evaluation of quantitative impedance plethysmography for continuous blood flow measurement. I. Electrode systems.


Synthesized EMG waves and their implications.


Intra-articular corticosteroid therapy.

Intra-articular corticosteroid therapy.


Parenteral administration of 6-alpha-methylprednisolone-21-acetate. II. Absorption and duration of effect.


Triamcinolone hexacetonide. A new corticosteroid for intra-articular therapy.


Quantification of spasticity. Preliminary report on a new method.


Function of the foot following arthrodesis.


Development of branches from internal mammary artery-myocardial implants.


Heterotransplantation of the aortic valve into the descending aorta.


Technique for reversed vein femoropopliteal graft.


Chylous cysts of mesentery.

Chylous cysts of mesentery.


Determination of the viability of muscle soon after wounding. Experimental studies using local dye for delineation of vital and nonvital muscle.


Hyperglycemia after gastrectomy as a prediabetic state. Clinical study of 100 postgastrectomy patients.


Inferior vena caval obstruction from increased intra-abdominal pressure. Experimental hemodynamic and angiographic observations.


Sclerosing lipogranulomatosis: its several abdominal syndromes.


Alterations in muscular and electrical activity of the stomach following vagotomy.


Gastrocolic fistula due to benign disease.


Injection of 5 percent phenol into submucosa of denervated gastric pouch.


Keratoacanthoma.

Keratoacanthoma.


Complications of acute pancreatitis. Unusual sequelae in 100 cases.


Cyanoacrylate adhesive and hemostasis.

Cyanoacrylate adhesive and hemostasis.


Higher homologous cyanoacrylate tissue adhesives in surgery of internal organs.


Resection of cardio-esophageal carcinoma. Factors contributing to its mortality, palliation, and cure.


Selective mucosal infarction of small bowel in incarcerated hernia.


Ureterovaginal fistula as a complication of radical pelvic surgery.


Recognition and management of massive pulmonary embolism. A report of successful embolectomy.


Giant cell carcinoma of the lung. Review of literature and report of five cases.


Spontaneous pneumothorax.

Spontaneous pneumothorax.


An improved gastrostomy dressing.

An improved gastrostomy dressing.


Amyloid-producing plasmacytoma of the pelvis. Case report and review of the literature.


Dr. Joseph Garland, editor and seer.

Dr. Joseph Garland, editor and seer.


Iron deficiency anaemia as a possible contributary factor in the development of dislocation of the hip.


Is discography a useful diagnostic procedure?


The management of acute leukemia.

The management of acute leukemia. The therapy of acute leukemia has improved rapidly in the last two decades. Using available therapeutic agents, complete clinical and hematological remission can be achieved regularly in children with acute lymphocytic leukemia. The choice of chemotherapeutic agent, management of complications of hemorrhage and infection, and recognition of prognostic factors are important for the induction of a hematological remission. While patients in complete hematological remission are free of evidence of disease they still have residual leukemic cells, but in our present state of knowledge and with available techniques, we are unable to detect these. For this reason it is important to treat patients while in remission. The importance of dosage schedule for remission maintenance chemotherapy is stressed.In patients studied to date, regardless of the treatment used, the disease has recurred eventually. Available therapeutic agents are highly effective and highly selective, but they still fall short of providing ideal control of the disease. The continuing search for new chemotherapeutic agents is aided by the knowledge gained and techniques developed with current agents.


The neurotoxic effect of water soluble contrast media in the spinal canal with emphasis on appropriate management.


Permanent implantation of endocardial tantalum screws: a new technique for functional studies of the heart in the experimental animal.


Cavitating secondary carcinoma of the lung.


Necrotic carcinoma of colon.

Necrotic carcinoma of colon.


Congenital anomaly of the cervical spine simulating fracture-dislocation--a case report.


Information--storage and retrieval.

Information--storage and retrieval.


Tannic acid and the barium enema with reference to dosage.


Progress in spleen scanning.

Progress in spleen scanning.


Combined synchronous voiding ciné-cystourethrography and cystometry in the investigation of vesicoureteral reflux in children.


Systemic tuberculin sensitivity in mice. I. Factors contributing to active tuberculin shock.


The behavior of autologous thyroglobulin in the circulation of rabbits immunized with either heterologous or altered homologous thyroglobulin.


Systemic tuberculin sensitivity in mice. II. Hypothermia as an indicator of tuberculin shock in actively and passively sensitized mice.


Systemic tuberculin sensitivity in mice. 3. The effects of adrenalectomy and treatment with antianaphylactic agents.


Characteristics of direct and indirect complement-fixing antibodies obtained from turkeys infected with ornithosis agent.


Rabbit antibodies induced by calf thymus histone-serum albumin complexes.


Structural characteristics of hemolytic antibodies as determined by the effects of ionizing radiation.


A quantitative precipitin study of porcine fibrinogen employing paired labels.


Studies on the neutralization of Japanese encephalitis virus. I. Application of kinetic neutralization to the measurement of the neutralizing potency of antiserum.


Duration of immunity to tuberculosis in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis strain BCG.


The effect of antigen on the rate of guanosine-8-C14 incorporation by lymphocytes.


A tissue hemadsorption inhibition neutralization test for Rubella antibody.


The incidence of HI antibody to Influenza virus A2/Singapore/ 1/57 in individuals of blood groups A and O.


Prediction and evaluation of outcome in an emergency brief psychotherapy clinic.


Nursing care of patients with lung abscess.


Rubella. I.

Rubella. I.


Steroid treatment of asthmatic children.


Reverse barrier nursing. 1. Care of patients with bone marrow depletion.


Reverse barrier nursing. 2. Care of patients with bone marrow depletion.


Accident and emergency departments; sisters' views.


. . . for the lodging of travellers.

. . . for the lodging of travellers.


Post tenebras lux.

Post tenebras lux.


Treatment of obesity by total fasting.

Treatment of obesity by total fasting.


The prices and incomes board.

The prices and incomes board.


A look at the facts.

A look at the facts.


The physical sciences and the patient's environment.


Wessex regional burns centre.

Wessex regional burns centre.


Conflicts and harmonies of normal stress. 2. Creative tension.


SCRIBE--a method for producing automated narrative psychiatric case histories.


The hemodynamic effects of the injection of contrast medium (Isopaque).


An analysis of mechanisms of post stenotic dilatation.


Congenital anomalies of the coronary arteries. A report of three cases.


Micronodular phlebosclerosis. An aging change of the venules of the kidney and adrenal.


The effects of pentaerythritol tetranitrate (PETN) on atrioventricular conduction following acute ligation of the anterior septal artery in dogs.


Modern amputations and prosthetics.

Modern amputations and prosthetics.


Syphilis therapy 1967.

Syphilis therapy 1967.


Antisepsis in the operating room.

Antisepsis in the operating room.


Modern management of burns.

Modern management of burns.


The modern hospital.

The modern hospital.


Bird Fancier's Lung.

Bird Fancier's Lung.


Mendelson's Syndrome: its treatment by tracheostomy and hydrocortisone.


Absorption of exogenous and endogenous proteolytic enzymes.


The effect of formulation on phenmetrazine plasma levels in man studied by a sensitive analytic method.


Changes in serum potassium levels occurring in patients treated with triamterene and a triamterene-hydrochlorothiazide combination.


The treatment of scopolamine-induced delirium with physostigmine.


Statistical ward rounds--3.

Statistical ward rounds--3.


Some applications of tritiated uridine to studies of mammalian cells in vitro.


Ulcerative colitis confined to the rectum and sigmoid flexure: report of 124 cases.


Effect of inhibitors of carbohydrate metabolism on the development of preimplantation mouse embryos.


X-ray visualization of rectal carcinoma after intravenous injection of polyvinylpyrrolidone (PVP): preliminary report.


Temperature-resistant variants in clonal populations of pig kidney cells.


Irrigation of the rectum with carcinocidal solutions during anterior resection: an improved technic.


Oleogranuloma simulating carcinoma of the rectum.


A comparative study of melanoma and epidermoid carcinoma of the anal canal: A review of 20 melanomas and 29 epidermoid carcinomas (1930 to 1965).


Studies on the relationships between cell population and growth kinetics of root meristems.


Colonic stomas.

Colonic stomas.


DNA synthesis in relation to cell division in Tetrahymena pyriformis.


Cell proliferation studies in the intestinal epithelium of the rat. Hyperplasia during lactation.


An unusual foreign body in the rectum.

An unusual foreign body in the rectum.


Electron microscopical observations of inhibitory effect of puromycin on liver regeneration after partial hepatectomy.


Stool patterns of healthy adult males.

Stool patterns of healthy adult males.


Repression by actinomycin D of testosterone induced sex reversal in Rana dalmatina tadpoles.


A study of the comparative effects of ionizing radiation and aging on the mammalian lens of the eye.


Studies on the relationship between iodine-131 deposited on pasture and its concentration in milk.


A rotational technique for assessing quantity and distribution of body radioactivity.


The maxima of Sutton's equation corrected for deposition.


Organic iodine-131 compounds released from a nuclear fuel chemical processing plant.


Transanal sphincter colocutaneous reconstruction: report of a case.


A large well crystal with anticoincidence shielding.


A concept of health physics dosimetry for quantum radiation.


Nonlinear amplifier for use in mixed radiation rem responding radiation meters.


An absolute neutron dosimeter based on a generalized concept for radiation dosimetry.


The use of probit analysis to estimate dose effects on postirradiation leukocyte depressions. (A preliminary report).


Ruby as a thermoluminescent radiation dosimeter.


Absorbed dose measurements with a portable calorimeter.


Recalculation of experimental and computed data from 600 kV pulsed x-rays.


A matrix method for the evaluation of beta-gamma dosimeter film.


Measuring plutonium in wounds: advantages of using the americium gamma ray.


Proton recoil track counting by television.


Thermal annealing effects on the thermoluminescence of lithium fluoride teflon disc dosimeters.


An indirect method of bone blood-flow measurement based on the bone clearance of a circulating bone-seeking radioisotope.


Marfan's syndrome with marked limb-length discrepancy. A case report.


A stockinette-Velpeau for immobilization of the shoulder-girdle.


Traumatic extrusion of the diaphyses of the radius and ulna successfully treated by replacement. Case report with five-year follow-up.


Acute and recurrent dislocation of the shoulder.


A consideration of infraspecific categories in the genus Echinococcus Rudolphi, 1801 (Cestoda: Taeniidae).


The genus Acanthobothrium van Beneden, 1849 (Cestoda: Tetraphyllidea).


Observations on the fine structure of the nervous system of Echinococcus granulosus.


Studies on Dactylogyrinae (Monogenea) with descriptions of 24 new species of Dactylogyrus, 5 new species of Pellucidhaptor, and the proposal of Aplodiscus gen. n.


A presumed sensory structure associated with the tegument of Schistosoma mansoni.


Fine structure of the reproductive system of a frog lung fluke. I. Mehlis' gland and associated ducts.


"Salmon poisoning" disease. 3. Effect of experimental Nanophyetus salmincola infection on the fish host.


Free amino acids of Australorbis glabratus hemolymph: comparison of four geographic strains and effect of infection by Schistosoma mansoni.


The life history of Phyllodistomum staffordi Pearse, 1924 (Trematoda: Gorgoderidae Looss, 1901).


Life history and taxonomy of Diplostomum variabile (Chandler, 1932) (Trematoda: Diplostomatidae).


Laterotrema cascadensis sp. n. (Trematoda: Stomylotrematidae) from the dipper, Cinclus mexicanus.


Acanthostomum (Atrophecaecum) alii sp. n. (Trematoda: Acanthostomidae) from the snake, Elaphe helena, in India.


Relationship between body weight and food and water intake in Trichinella spiralis-infected guinea pigs.


Glucose malabsorption and intestinal histopathology in Trichinella spiralis-infected guinea pigs.


Nematode parasites of oceanica. I. Brevistriata sundasciuri sp. n. and Calypsostrongylus ogdeni gen. et sp. n. (Heligmosomatidae: Longistriatinae) from squirrels of Palawan and Taiwan.


Angiostrongylus michiganensis sp. n. (Nematoda: Metastrongyloidea), a lungworm occurring in the shrew, Sorex cinereus cinereus, in Michigan.


Ferritin-conjugated antibody studies on the larvae of Trichinella spiralis.


The in-vitro development of Cooperia pectinata, a nematode parasite of cattle, from third-stage larvae to adults, including egg production.


Acanthocephala from Kenya with descriptions of two new species.


Survival of sporozoites of Plasmodium gallinaceum Brumpt for 767 days in liquid nitrogen (-197 C).


Course of infection of Leishmania donovani in hamsters inoculated by the intraperitoneal route.


Drug tolerance by Tritrichomonas foetus.


Chlorine-induced resistance to Bayluscide in the eggs of Australorbis glabratus.


Susceptibility of the American opossum to infection by Trypanosoma gambiense.


Age dependency of tissue resistance to Trichinella spiralis in Chinese hamsters.


Trypanosoma cruzi cultivation in Trypticase Soy Broth with hemin and serum.


Further studies on susceptibility of Alilao race of Oncomelania formosana to infection with various strains of Schistosoma japonicum.


Resistance of cercariae of Schistosoma mansoni to mechanical traumata.


The protection of mice by "Corpus Christi" strain of Trypanosoma cruzi when challenged with "Brasil" strain.


Problems in sizing.

Problems in sizing.


Red cell metabolism in the premature infant. II. The pentose phosphate pathway.


Studies of acid-base disturbances.

Studies of acid-base disturbances.


Aldosterone secretion rates in normal subjects from infancy to adulthood.


Medical help and maternal nursing care in the life of low-income families.


A program to increase health care for children: the pediatric nurse practitioner program.


Response of medulloblastoma to vincristine sulfate: a case report.


Diagnosis and treatment: interpreting the positive screening test in the newborn infant.


Acute phenothiazine toxicity in childhood: a five-year survey.


The prophylactic use of folic acid in neonatal hypertyrosinemia.


Streptococcal M protein antibodies acquired at birth.


Who has the last word? A look at pediatric pathology.


Hypertension and seizures following methyldopa infusion.


Submarine escape from one hundred fathoms.


Escape from vehicles under water.

Escape from vehicles under water.


Reflux reflections.

Reflux reflections.


The management of anaesthesia in sickle cell states.


Combined adrenal and thyroid deficiency with plasma antibodies.


Pluriglandular syndrome: multiple endocrine neoplasia.


An unusual mediastinal tumour defined with radioiodine.


The assessment of dose requirements of pergonal.


Current trends in the treatment of amenorrhoea with human gonadotrophin.


The prevention of influenza by influenza vaccine.


Prevention of influenza by vaccination.

Prevention of influenza by vaccination.


The fruits of error and false assumption.


Hypopituitary dwarfism.

Hypopituitary dwarfism.


Specialist training in Great Britain today as seen by a trainee.


Weightlessness in the treatment of bedsores and burns.


Clinical and physiologic studies in pulmonary thromboembolism.


Lethal tricuspid and mitral regurgitation in Marfan's syndrome.


Opacification of the right heart complicating left ventricular angiography.


Control of thoracic dissecting hematoma. Case report with serial aortograms.


"Asplenic syndrome" in association with rudimentary spleen.


Clinical signs of severe acute mitral regurgitation.


Influence of respiration on recording cardiac potentials. Isopotential surface-mapping and vectorcardiographic studies.


Cardiac potentials in pulmonary disease. Overdistension of the lung versus cor pulmonale (right ventricular hypertrophy).


The butterfly pattern of acute pulmonary edema.


Clinical pathologic conference. Subacute cor pulmonale.


Mechanism of neurogenic pulmonary edema.


Paroxysmal pulmonary edema and the acute cardiac lung.


Anomalies of the pulmonary veins.

Anomalies of the pulmonary veins.


Partial anomalous pulmonary venous connections.


Survival and the sex ratio in trisomy 17-18.


A case of XX/XY mosaicism.

A case of XX/XY mosaicism.


On the selective advantage of cystic fibrosis heterozygotes.


Haptoglobin: a locus on the D1 chromosome?


Distinction between chromosome 4 and chromosome 5 by replication pattern and length of long and short arms.


The relationship of the presence of disease to birth order and maternal age.


The syndrome of pits of the lower lip and cleft lip and/or palate. Genetic considerations.


A possible relationship between birth month and ABO blood type.


Begin tomorrow.

Begin tomorrow.


The indirect basophil degranulation test.


Physical signs of allergy of the respiratory tract in children.


Specific and nonspecific passive desensitization. XI. Effect of simultaneous administration of sensitizing and desensitizing antisera on passive sensitization and desensitization.


The lepra reaction with necrotizing skin lesions. A report of six cases.


Inability to induce keratinization in basal cell tumors. Wounding and application of resin podophyllum.


Desquamation of the human horny layer.

Desquamation of the human horny layer.


Hereditary epidermolysis bullosa.

Hereditary epidermolysis bullosa.


Ultrastructural observations on lichen planus.


Pustular patch test--experimentally induced.


Local thiabendazole in the treatment of creeping eruption.


Bullous amyloidosis. A case report.

Bullous amyloidosis. A case report.


Allergic contact dermatitis to methyl and propyl paraben.


Adrenergic focal sweating.

Adrenergic focal sweating.


Vidian nerve section for vasomotor rhinitis.


Sensorineural hearing loss for low tones.


The dizzy patient. Eliciting his history.


Another syndrome of familial hereditary deafness.


Ossicular homograft. Preliminary results.


Serial section radioautography of the inner ear. Histological technique.


Incus homograft viability in cats.

Incus homograft viability in cats.


Vascular tinnitus. A case report.

Vascular tinnitus. A case report.


Sudden deafness. An otologic emergency.

Sudden deafness. An otologic emergency.


Fibromatous polyp of hypopharynx presenting from the mouth.


Chemodectoma of the "glomus laryngicum inferior".


Ceruminous gland tumors.

Ceruminous gland tumors.


Cystic hygroma of the neck. Report of a case.


Tobacco habits in carcinoma of the upper respiratory tract.


Cleft larynx.

Cleft larynx.


Use of silicone-rubber in nasal reconstructive surgery.


Surgeon's glove powder (starch) middle ear granuloma.


The template technique for cleft lip repair.


Autologous transplantation of the canine larynx.


Electron microscopy of nonbacterial valvular vegetations in rats with arteriovenous shunts.


Cholangiofibrosis in the liver of buffalo strain rats injected with carbon tetrachloride.


Platelets and atherogenesis. I. Augmentation of cholesterol atherogenesis in the rabbit by a phlebotomy programme designed to induce thrombocytosis.


Arteriosclerotic stenosis of the intramural coronary arteries of chickens: further evidence of a relation to social factors.


Malignant melanoma of the oral cavity in Ugandan Africans.


Teratoma of the liver in an African child.


Hyperbaric oxygen therapy in experimental staphylococcal infection.


Inferior vena caval obstruction complicating vertebral column disease.


The treatment of acute postanal pilonidal abscess.


The sites to which pain is referred from the common bile-duct in man and its implication for the theory of referred pain.


Recovery of bladder function in paraplegia.


The case for peroperative cholangiography.


Variations in oxyhaemoglobin dissociation with age, smoking, and Buerger's disease.


The management of cardiac tamponade. Drainage of pericardial effusions.


Division of the external sphincter in the treatment of the neurogenic bladder.


Acid-base changes after gastric surgery.


Unusual features of primary duodenal cancer.


Austin Moore prosthesis. Comparison of results in the treatment of fractured femoral neck and arthritis of the hip.


Peripheral emboli following aortic grafting.


Malignant melanoma with an occult primary lesion.


Teratoma of the spinal cord.

Teratoma of the spinal cord.


Rupture of a renal artery aneurysm presenting with severe haematuria and clot retention.


Combined active-passive immunization against tetanus in man. A schedule for the prevention of tetanus in the injured, which has been in operation in the emergency department of a large hospital for over two years, is proposed. For the majority of nonimmunized persons, it is recommended that a dose of toxoid and 50 units tetanus immune globulin (human) (TIGH) be given, in separate sites, to be followed later by additional doses of toxoid for the completion of active immunization. Combined active-passive immunization with tetanus toxoid and 50 units TIGH gives a low level of passive immunity and stimulates early onset of active immunization. In combined active-passive immunization, adsorbed tetanus toxoid produced a significantly higher response than the fluid toxoid. The injection of 400 units TIGH somewhat suppressed the induction of immunity following the first dose of AlPO(4)-tetanus toxoid.


Unilateral fixation of the ossicular chain associated with G-group chromosome deletion. Unilateral fixation of the middle ear ossicles and possible delayed pubescence were associated with a short-arm deletion of one of the G-group chromosomes in a 15-year-old Negro girl. A similar chromosomal abnormality was found in the mother and three of six siblings without any clinical evidence of middle ear disease. The association of G-group deletions with other hereditary disease of bone suggests, however, that a pathogenic relationship may exist between them.


A study of the work of a medical social worker in a group medical practice. An exploratory study was made to demonstrate the role, the work and the relationships of a full-time medical social worker in a group medical practice. Patients were seen on referral only, and a schedule for interview was developed for purposes of categorizing areas of social dysfunction. The following areas of dysfunction were studied: accommodation, job, social activities, family problems and medical diagnosis and/or treatment. A profile emerged of the patients referred as compared to patients in the practice as a whole. The "social sickness" in patients was more likely to exist between the ages of 20 and 44 years or over 65. It occurred more frequently in females and in individuals living alone or in a family of seven or more, in people from the lower social classes and the unemployed, retired people or actual or potential social isolates, those having a psychological illness, and those with degenerative disease of the circulatory or central nervous systems. It was less frequent in patients from a farm.


Medical ecumenics.

Medical ecumenics.


End results in cancer of the breast.

End results in cancer of the breast.


Résumé of standard surgical procedures at Memorial Hospital.


Locally recurrent cancer after radical mastectomy.


Discussion from symposium on cancer of the breast.


Testicular tumors. Analysis of 196 cases treated at the U.S. Naval Hospital in San Diego.


Induced resistance of mice to a lymphoid strain of leukemia virus (Moloney).


Musculo-aponeurotic fibromatosis of the shoulder girdle (extra-abdominal desmoid). Analysis of thirty cases followed up for ten or more years.


Oral epithelial changes in thirty Indians with oral cancer and submucous fibrosis.


Intra-abdominal extrapancreatic neoplasm (leiomyosarcoma) associated with severe recurrent hypoglycemia. Report of a case.


Mortality from cancer of the stomach in Costa Rica.


The current pattern of internal derangements of the knee joint relative to the menisci.


Well leg traction--an efficient but neglected procedure.


Tennis elbow.

Tennis elbow.


Balanced traction-suspension for a fractured femur in a thrashing patient.


Congenital posterior angulation of the tibia.


Anatomic structures of the thoracic outlet.


Acute severe slipped capital femoral epiphysis.


Criteria for the histologic diagnosis of bronchogenic carcinoma.


The thoracic outlet syndrome from a neurosurgical point of view.


Identification of active pulmonary cavitary disease by barium bronchogram technique.


The effect of potassium on the electrocardiogram: clinical and transmembrane correlations.


Letter to the editor: talipes equinovalgus.


Comparison between the Valsalva maneuver and a newly-devised expiratory valve on splitting of the second heart sound.


Bronchopulmonary candidiasis: clinical aspect.


Surgical approaches to neurovascular compression syndromes of the neck.


The roentgen-ray diagnosis of intrapulmonary lymph nodes.


Sputum induction by newer inhalation methods in patients with pulmonary tuberculosis.


Tuberculin testing of the aged.

Tuberculin testing of the aged.


Isolated atrial infarction.

Isolated atrial infarction.


Forearm fractures in children.

Forearm fractures in children.


Pulmonary subvalvular tumor.

Pulmonary subvalvular tumor.


Roentgenogram of the month.

Roentgenogram of the month.


The distal radio-ulnar joint.

The distal radio-ulnar joint.


Left hilar thymoma. Report of a case.

Left hilar thymoma. Report of a case.


Mitral insufficiency in Marfan's syndrome. A case report of surgical correction.


Recurrent bacterial endocarditis due to Salmonella Newport and Diphtheroid bacillus. Report of a case with cure.


Superior vena cava syndrome secondary to aortic disease.


Bronchography. A report of the Committee on Bronchoesophagology. American College of Chest Physicians.


Worldwide chest medicine. Some recent medical developments in Bulgaria.


Complete surgical period of the cardiac patient. The role of the internist-cardiologist.


Pancreatic scanning.

Pancreatic scanning.


A statistical perspective on the aging population.


Assessing the impact of a gerontological counseling service on community health resources.


Who will care for the aging population? Report charts changing M.D. role.


Storage of pleasures: the physician's role.


Senile lack of cleanliness.

Senile lack of cleanliness.


Family care program for older people.

Family care program for older people.


Anticoagulant therapy in myocardial infarction.


Effect of gravitational and inertial forces on pleural and esophageal pressures.


Training of the oxygen transport system in man.


Intraesophageal pressure gradient in man.


Measurement of alveolar pressure.

Measurement of alveolar pressure.


Respiratory changes in pleural pressures at different sites and body positions.


Transthoracic ventricular defibrillation with very high amplitude rectangular pulses.


Alveolar pressure, airflow rate, and lung inflation in man.


Stratified distribution of blood flow in secondary lobule of the rat lung.


An analog computer analysis of regional diffusing capacity in airflow obstruction.


Determination of body temperature by infrared emission.


A design for a miniature biopotential radio transmitter.


A plastic-cannulated intestinal loop to study effects of anesthesia on Ca absorption.


Determination of sulfobromophthalein storage and exertory rate in small animals.


A photoelectric volume transducer for use with a water-filled plethysmograph.


A convenient skin button connector for withdrawal of blood samples.


Errors in capillary viscometry of blood: significance of correction for velocity pressure.


Theoretical and experimental study of transplacental diffusion.


Preparation of combined sodium-sensitive and reference microelectrodes.


The group approach to the asthmatic child and family.


Group social work with children.

Group social work with children.


Group milieu in a hospital.

Group milieu in a hospital.


Group therapy of parents who have children in residential or day care psychiatric treatment.


The evolution of allergies in childhood.


Studies with isoetharine. II. Cardiovascular effects in hypertensive patients with expiratory airflow disorders.


Allergy and infection. V. Proof of infectious etiology.


Serum protein studies in intractable asthma.


Pathways of ammonia metabolism in the intact functioning kidney of the dog. Studies in which (15)N-labeled precursors of urinary ammonia were infused into the artery of an intact functioning kidney of an acidotic dog have led to the following conclusions: Preformed ammonia and ammonia derived from the amide nitrogen of plasma glutamine are added directly to urine without significant incorporation into amino acid intermediates of renal tissue. Thus, reductive amination of alpha-ketoglutarate to form glutamate does not occur to an appreciable extent nor is there significant transfer of the amide nitrogen of glutamine to the corresponding keto acids to form glutamate, aspartate, alanine, or glycine. The enzyme system "glutaminase II" may participate to a significant extent in the metabolism of glutamine by forming aspartate and alanine by direct transamination of oxalacetate and pyruvate and liberating the amide nitrogen as ammonia. Renal alanine exists as a well mixed pool derived in roughly equal amounts from filtered and reabsorbed plasma alanine and newly synthesized alanine. The alanine pool of tubular cells does not equilibrate with the alanine of peritubular capillary blood. Transfer of the nitrogen of alanine to alpha-ketoglutarate and subsequent oxidative demination of the resulting glutamate can account for the ammonia formed from alanine. Glycine is not an important intermediate in renal nitrogen metabolism.


The renal clearance of amino acids in cystinuria. The renal clearance of cystine, lysine, ornithine, arginine, and glycine has been compared with the simultaneously determined glomerular filtration rate in nine cystinuric patients. Five were studied before and after stabilization on penicillamine therapy, two were studied only while taking penicillamine, and two were studied only in the absence of penicillamine administration. The renal clearances of cysteine-penicillamine and of penicillamine disulfide were also determined in the patients who were taking the drug. Amino acids were determined by quantitative ion exchange chromatography, and the reliability of the method has been evaluated in terms of its reproducibility and of the recovery of known amounts of amino acids added to plasma and to urine. The plasma levels of cystine and of the basic amino acids were less than normal in all the patients. Cysteine-penicillamine and penicillamine disulfide were cleared by the kidney at rates similar to that of cystine. Two of the patients had glycine clearances that were considerably above the normal value. The renal clearance of cystine exceeded the glomerular filtration rate in six of the nine patients. The results form a continuum from values approximately equal to the glomerular filtration rate to values about twice this amount. The renal clearances of cystine and of the basic amino acids vary independently of one another in the disease. The significance of these results is discussed in terms of the nature of the renal tubular transport defect that underlies the disorder.


Abnormalities of high density lipoproteins in abetalipoproteinemia. DETAILED STUDIES OF THE HIGH DENSITY LIPOPROTEINS FROM THREE PATIENTS WITH ABETALIPOPROTEINEMIA HAVE REVEALED THE FOLLOWING PRINCIPAL ABNORMALITIES: 1) High density lipoprotein 3 (HDL3) is reduced in both absolute and relative concentration, although HDL2 is present in normal amounts. 2) The phospholipid distribution of both HDL fractions is abnormal, with low concentrations of lecithin and an increased percentage (though normal absolute quantity) of sphingomyelin. 3) In both HDL fractions, lecithin contains less linoleate and more oleate than normal. The cholesteryl esters are also low in linoleic acid, and the sphingomyelin is high in nervonic acid. Dietary intake influences the linoleic acid concentration within 2 weeks, and perhaps sooner, but the elevated sphingomyelin nervonic acid is little affected by up to 6 months of corn oil supplementation. Qualitatively similar changes in fatty acid composition, but not phospholipid distribution, are also found in other malabsorption states. The available evidence suggests that the abnormally low levels of HDL3 and the deranged phospholipid distribution are more specific for abetalipoproteinemia than the fatty acid abnormalities. However, the absence of these abnormalities in obligate heterozygous subjects makes their relationship to the primary defect of abetalipoproteinemia difficult to assess.


Acid-base alterations and renal gluconeogenesis: effect of pH, bicarbonate concentration, and PCO2. In previous studies it was found that renal cortical slices from rats with induced metabolic acidosis have an increased capacity to produce glucose, whereas cortical slices from rats with metabolic alkalosis manifest decreased gluconeogenesis. To evaluate the relative influence of extracellular fluid pH, [HCO(3) (-)], and carbon dioxide tension on renal gluconeogenesis, we observed glucose production by cortex from rats with induced respiratory acidosis, and by cortex taken from normal animals and incubated in acid and alkaline media. We found glucose production to be increased in cortex from rats with respiratory acidosis, as is the case in metabolic acidosis. Glucose production by slices from normal rats was increased in media made acidic by reducing [HCO(3) (-)], and decreased in media made alkaline by raising [HCO(3) (-)]. These effects were evident whether the gluconeogenic substrate employed was glutamine, glutamate, alpha-ketoglutarate, or oxalacetate. Glucose production was also increased in media made acidic by raising CO(2) tension and decreased in media made alkaline by reducing CO(2) tension. These data indicate that both in vivo and in vitro, pH, rather than CO(2) tension or [HCO(3) (-)], is the most important acid-base variable affecting renal gluconeogenesis. The findings suggest that a decrease in extracellular fluid pH enhances renal gluconeogenesis through direct stimulation of one of the rate-limiting reactions involved in the conversion of oxalacetate to glucose. We hypothesize that the resultant increase in the rate of removal of glutamate, a precursor of oxalacetate, may constitute an important step in the mechanism by which acidosis increases renal ammonia production.


Functional characteristics of the diluting segment of the dog nephron and the effect of extracellular volume expansion on its reabsorptive capacity. The functional characteristics of the ascending limb of Henle's loop were examined during hypotonic saline infusion by measuring solutefree water clearance (C(H2O)) at varying rates of solute delivery. The influence of expansion of extracellular volume was studied by comparing C(H2O) during hypotonic saline diuresis in normal dogs with dogs whose extracellular volume had been expanded acutely by saline infusions or chronically by the administration of deoxycorticosterone acetate and salt. In normal animals hypotonic saline infusions greatly increased urine flow (V) and C(H2O) without appreciably augmenting osmolar clearance (C(osm)). C(H2O) was, therefore, analyzed as a function of V, rather than C(osm), since V was the best estimate of delivery of filtrate to the diluting segment. C(H2O) increased as a linear function of V without any evidence of saturation.The validity of interpreting increases in C(H2O) and V as indications of increased sodium reabsorption and delivery was reinforced by tissue studies that disclosed a rise in papillary osmolality with rising urine flows. The observed increase in C(H2O) and V could not, therefore, be due to a decrease in back diffusion of solute-free water as a result of a diminished osmotic driving force, but probably represented increased formation consequent to augmented delivery as a result of decreased fractional reabsorption in the proximal tubule. In animals whose extracellular volume was acutely or chronically overexpanded before the infusion of hypotonic saline, sodium excretion was greater, and C(H2O) less, at any given V. Although the curve relating C(H2O) to V was flatter than in the control group, no tubular maximum was observed. The diminished C(H2O) in this group was interpreted to mean that massive expansion of extracellular volume inhibits sodium reabsorption in the ascending limb of Henle's loop.


Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig. If water and inert solutes are assumed to pass from blood to bile through a fixed population of membrane pores, the changes in clearance produced by dehydrocholate suggest that osmotic filtration rather than diffusion is the predominant mode of transfer for mannitol and erythritol. Bile produced in the canaliculi is modified in the interlobular ducts by the action of secretin. If distal fluid transfer is an important determinant of the choleresis evoked by dehydrocholate, the mechanism appears to effect a net secretion or reabsorption of fluid at a rate roughly proportional to the rate of flow in the canaliculi.


Erythrocyte energy metabolism in hereditary spherocytosis. The incorporation of extracellular orthophosphate-(32)P into cellular ATP, 2,3-diphosphoglyceric acid, and inorganic phosphate has been measured over a period of 6 hours in vitro in red blood cells from normal subjects and from patients with hereditary spherocytosis who had undergone splenectomy. The pattern of labeling of the intracellular compounds was found to be the same in both types of red blood cells, as reported by other workers using much shorter periods of incubation. In addition, in the present study it was possible to compare the net flux of extracellular phosphate into ATP between the two groups of erythrocytes. These latter results suggest that the actual turnover rate of ATP was not abnormal in these patients with hereditary spherocytosis.


Effects of hypotonic saline loading in hydrated dog: evidence for a saline-induced limit on distal tubular sodium transport. We performed studies on dogs under hydrated conditions, utilizing the rate of free water formation (C(H2O)) as an index of the rate of distal tubular sodium transport. Since C(H2O) could be progressively increased with no evidence of a maximal rate during loading with hypotonic (2.5%) mannitol, it was concluded that there is no limit on distal tubular sodium transport during mannitol loading. In contrast, during hypotonic (0.45%) saline loading C(H2O) rose initially, but as urine flow (V) exceeded 25% of the filtered load C(H2O) attained maximal levels (up to 20% of the filtered load) and remained stable as V increased to 50% of the filtered load. It was concluded that saline loading progressively inhibits proximal sodium reabsorption. Initially, the distal tubule absorbes a large fraction of the proximal rejectate and sodium excretion rises slightly. Eventually, an alteration in distal sodium transport appears which culminates in a maximal rate or transport limit. This distal transport limit provoked by saline loading could not be characterized by a classical Tm as seen with glucose and does not seem to be consequent to high rates of flow through the distal tubule. Regardless of the precise nature of this limit, the major increment in sodium excretion develops during saline loading only after saline alters the capacity of the distal tubule to transport sodium.


Intrinsic factor-mediated attachment of vitamin B12 to brush borders and microvillous membranes of hamster intestine. Hamster intrinsic factor (IF) preparations markedly enhanced the uptake of (57)cobalt-labeled cyanocobalamin (B(12)-(57)Co) by brush borders and microvillous membranes isolated from villous absorptive cells obtained from the distal but not the proximal half of hamster intestine. A similar effect was observed with rat and rabbit IF preparations, but IF preparations obtained from man, dog, and hog were ineffective. After fractionation of hamster IF preparations by gel filtration or ion exchange chromatography, the extent to which each fraction enhanced B(12)-(57)Co uptake by brush borders correlated closely with the vitamin B(12) binding capacity of the fraction. IF-mediated attachment of B(12)-(57)Co to brush borders occurred rapidly, was not diminished by removal of glucose or oxygen from the incubation medium, and was not significantly altered when incubation temperatures were reduced from 37 degrees C to 7 degrees C. Marked reduction in uptake occurred, however, in the absence of divalent cations. IF enhanced B(12)-(57)Co uptake by brush borders isolated from the proximal half of the intestine when these proximal brush borders were preincubated with supernatant fluid obtained after centrifugation of homogenates of distal intestinal mucosa at 28,500 g. The factor in this supernate responsible for the effect on proximal brush borders was shown to be particulate in nature upon centrifugation at speeds of 54,500 g or greater. The resultant pellet contained ribosomes and membranous fragments. Prolonged incubation of brush borders with crude saline extracts of hamster gastric mucosa resulted in decreased uptake of B(12)-(57)Co and marked lysis of brush borders with concomitant release of tissue nitrogen. Neither lysis of brush borders nor decreased uptake of B(12)-(57)Co with prolonged incubation was observed when hamster IF was partially purified. Furthermore, uptake of B(12)-(57)Co by brush borders increased with increasing purity of the IF preparation used. These results demonstrate IF-mediated attachment of B(12)-(57)Co to brush borders and microvillous membranes of hamster intestinal cells and provide further support for the presence of a specific receptor for IF-bound vitamin B(12) at the microvillous surface of the intestinal cell. IF-mediated attachment to the intestinal cell surface appears to be facilitated by divalent cations and to result from adsorption rather than an energy-requiring enzymatic reaction. Crude sources of hamster IF contain a factor which causes lysis of brush borders in vitro and which may explain in part the inhibitory effects of IF excess previously observed in vitro.


The effects of infusion of water on renal hemodynamics and the tubular reabsorption of sodium. Anesthetized dogs receiving an infusion of chlorothiazide and ethacrynic acid were given 600-ml infusions of distilled water or dilute dextrose solutions. The absolute rate of tubular sodium reabsorption was depressed, and the glomerular filtration rate was increased during the water loading, despite the associated decreases in plasma sodium concentration and decreases in the filtered load of sodium. The extent to which fractional sodium reabsorption decreased and the excretion of sodium increased was inversely related to the degree to which the filtered load of sodium was depressed as a result of the decreased plasma sodium concentration. We conclude that, in the presence of the diuretic blockade of distal tubular sodium reabsorption, infusion of water depresses proximal tubular reabsorption of sodium and that these changes are qualitatively similar to those previously observed during infusions of saline. Similar depression of tubular reabsorption of sodium and increased excretion of sodium occurred during water loading in the absence of diuretics in dogs undergoing saline diuresis, which presumably provided a high rate of distal sodium reabsorption before water loading. We suggest that volume expansion with water depresses proximal tubular reabsorption of sodium in a manner qualitatively similar to infusions of saline and that the extent to which sodium excretion is increased during water loading is dependent upon 1) the absolute extent to which proximal reabsorption is depressed, 2) the extent to which the filtered load of sodium is maintained in the presence of a falling concentration of sodium in plasma, and 3) the extent to which increased distal reabsorption compensates for the depressed proximal reabsorption of sodium. Mechanisms are suggested whereby the previously reported inverse relationship between plasma concentration of sodium and over-all tubular reabsorption of sodium may be only apparent, and could be the result of physiologic "glomerulotubular balance" during the specific experimental maneuvers.


Changes in proximal and distal tubular reabsorption produced by rapid expansion of extracellular fluid. Acute infusions of isotonic saline in the rat cause an increase in glomerular filtration rate and in the excretion of salt and water. The kidney swells, due to expansion of tubular and interstitial volume. Despite the increase in tubular diameter, transit time through the proximal tubules and loops of Henle is decreased, presumably owing to a greatly accelerated rate of tubular flow. Proximal tubular reabsorption, measured in blocked tubules, is inhibited in a way that cannot be ascribed to changes in tubular diameter. The prolongation of proximal reabsorptive half-time is not affected by the administration of aldosterone. It occurs equally in rats chronically loaded with or deprived of salt, and it is therefore not likely that it is influenced by the renal content of renin. In contrast, reabsorption from the distal convoluted tubule is enhanced by saline infusion. This change is observed in segments of tubules blocked with oil and isolated from their glomeruli and thus appears to occur independently of changes in glomerular filtration or tubular flow.


Quantitative measurement of alcohol dehydrogenase in the lobule of normal livers.


Re-evaluation of radio-iodinated triolein as a test fat in fat absorption studies.


Increased intracranial pressure from unsustained levels of plasma mannitol during hemodialysis.


Materials indistinguishable from iodotyrosines in normal human serum and human serum albumin. Materials indistinguishable from authentic mono- and diiodotyrosines were identified in extracts of normal human serum as well as in extracts of purified human serum albumin. These materials were not found in association with the other serum proteins. Identification of MIT and DIT was made by a technique using rechromatography to constant specific activity, as well as by the Barker wet ash distillation method, which established the compounds in question as being iodinated ones. By two different extraction and chromatographic methods we estimated the amounts of both MIT and DIT present in normal human serum or albumin; the estimates were in good agreement. These compounds together constituted between 19% and 25% of the extractable serum iodine.


Intestinal iron absorption by neonates and some factors affecting it.


Effects of in vivo hyperoxia on erythrocytes. VI. Hemolysis occurring after exposure to oxygen under high pressure.


Impairment of platelet function and thrombus growth in reserpine-treated rabbits.


Erythroid differentiation during stem cell proliferation.


Abnormalities of serum monoamine oxidase in chronic liver disease.


Primaquine sensitivity in Caucasians: hemolytic reactions induced by primaquine in G-6-PD deficient subjects.


Bone remodeling in puppies with experimental rickets.


Neomycin feeding in the rat: studies of intestinal absorption of glucose and xylose.


Endocytosis in thyroid follicle cells. V. On the redistribution of cytosomes following stimulation with thyrotropic hormone.


The stereo ultrastructure of the external and internal surface of the cornea.


The organization of sarcoplasmic reticulum in direct flight muscle of the lepidopteran Achalarus lyciades.


Serial section analysis of mitochondrial form and membrane relationships in the neonatal rat liver cell.


Electron microscope observations on thick filaments isolated from striated muscle.


The structure of pores in isolated pea nuclei.


Virus-like particles in cultures of McCoy cells.


Atypical intestinal striated muscle in Drosophila melanogaster.


Desensitization for asthma in identical twins.


Continuous compression technique of injecting varicose veins.


Significant variations in the shape of the trachea and large bronchi.


"Peritoneal tap" as an aid to early diagnosis of intra-abdominal injury.


The tyramine test for phaeochromocytoma.


Goodpasture's syndrome.

Goodpasture's syndrome.


Of one hundred thousand encounters.

Of one hundred thousand encounters.


The planning and financing of national health services.


Thoracic hydatid cysts.

Thoracic hydatid cysts.


Management of malignant hypertension.

Management of malignant hypertension.


The sensor for stress.

The sensor for stress.


Management of malignant hypertension complicated by renal insufficiency.


Catecholamine release in familial dysautonomia.


Longevity and medical costs.

Longevity and medical costs.


Physician, know thyself.

Physician, know thyself.


Lycoperdonosis.

Lycoperdonosis.


Case records of the Massachusetts General Hospital. Case 29-1967.


The use and abuse of vasodilator drugs.

The use and abuse of vasodilator drugs.


Prophylactic digitalization and acute coronary occlusion in dogs.


Unilateral pulsating varicose veins in tricuspid regurgitation resembling arteriovenous fistula. Report of a case.


Prognosis in extra-abdominal neuroblastoma.


Plasma triglyceride rise in the rat following hypothalamic stimulation.


Technique and dose distribution for treatment of cancer of the larynx with a cesium unit.


Effect of splenectomy followed by cyclophosphamide or total body irradiation on hemopoiesis in rats.


Influence of gestation and lactation on radiostrontium-induced malignancies in mice. II. Retention of radiostrontium and relation between tumour incidence and excretion rate.


Cobalt 60 teletherapy of carcinoma of the bladder.


Distribution of zirconium and niobium in mice. Autoradiographic study.


Spontaneous rupture of an abdominal aortic aneurysm into the inferior vena cava. Report of a case, with successful repair.


An embryologic theory for ventricular inversions and their classification.


Work, the opiate of some people?

Work, the opiate of some people?


A new hereditary acanthocytosis syndrome.


Nutrition and infection field study in Guatemalan villages, 1959-1964. II. Field reconnaissance, administrative and technical; study area; population characteristics; and organization for field activities.


Plasmacytic myeloma.  A study of the relationship of survival to various clinical manifestations and anomalous protein type in 112 patients.


The mechanism of hypertension in the Guillain-Barré syndrome.


Hyperlipemia in acute pancreatitis. Metabolic studies in a patient and demonstration of abnormal lipoprotein-triglyceride complexes resistant to the action of lipoprotein lipase.


Two experimental general practices. United Kingdom and United States.


Urban tetanus. The epidemiologic aspects of tetanus in narcotic addicts in New York City.


The medical data screen. An adjunct for the diagnosis of 100 common diseases.


Occupational hearing loss and high frequency thresholds.


Epidemiologic study of occupational lung cancer.


Ultrastructural alterations of alveolar tissue of mice. II. Synthetic photochemical smog.


A chemical test for smoking exposure.

A chemical test for smoking exposure.


Proteinuria of workers exposed to cadmium fume. The relationship to concentration in the working environment.


Selenium-fluoride interaction in relation to dental caries.


The mechanisms of some structural alterations of the lung.


Time study of general practitioners' office hours.


The use of preventive medicine case summaries in teaching and research.


Differences in duration of pregnancy. Negro and white women of low socioeconomic class.


The neighborhood health center. Education of the faculty in preventive medicine.


The evaluation of new drugs. Current Food and drug Administration regulations and statistical aspects of clinical trials.


Malabsorption studies in cirrhosis of the liver.


The half-and-half nail.

The half-and-half nail.


Fecal fat excretion. An analysis of four years' experience.


Split renal function studies in hypertension.


Induced intravascular thromboembolic phenomena. Direct observation in the living extracorporeal eye.


Gastrointestinal manifestations of hyperparathyroidism.


Renal vascular abnormalities in acute pancreatitis.


Myocardopathy, alcohol, and pericardial effusion.


Intermittent claudication and polymyalgia rheumatica. Association with panarteritis.


Subacute constrictive uremic pericarditis.


Ten-year follow-up of treatment of two phenylketonuric brothers.


Hand, foot and mouth disease in south Wales, 1964.


Scrotal dermatophytosis. An insufficiently documented aspect of tinea cruris.


Treatment of chromoblastomycosis with high local concentrations of amphotericin B.


Induced ribotide reductive conversion defect by hydroxyurea and its relationship to megaloblastosis.


Comparison of the growth of the Ehrlich ascites tumor in male and female mice.


Relationship of infecting dose to recovery of Rauscher murine leukemia virus (RMLV) in random bred Swiss mice.


The effect of B vitamin and protein intake of the rat on the antitumor activity of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone).


Effects of uracil mustard on DNA, RNA, and protein biosynthesis in tissues of A-J mice.


Kinetics of cell proliferation of an experimental tumor.


The effect of dietary mineral supplements of the rat on the antitumor activity of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone).


Morphologic and synthetic response of normal and tumor muscle cultures to nickel sulfide.


Cor triatriatum. Review of the surgical aspects with a follow-up report on the first patient successfully treated with surgery.


The electrophysiological properties of diphenylhydantoin sodium as compared to procaine amide in the normal and digitalis-intoxicated heart.


Protection from digitalis toxicity with the prophylactic use of diphenylhydantoin sodium. An arrhythmic-inotropic dissociation.


Antihypertensive properties of furosemide.


Decision rules in electrocardiography and vectorcardiography.


Clinical implications of blood rheology studies.


Exercise and intermittent claudication. I. Effect of repetition and intensity of exercise.


Exercise and intermittent claudication.II. Effect of physical training.


Assessment of aortic valvular stenosis from the aortic pressure pulse.


Distribution of arterial lesions demonstrated by selective cinecoronary arteriography.


Electrocardiographic changes in clinically normal older men following near maximal and maximal exercise.


Vectorcardiographic changes during intracoronary injections.


Coronary disease in familial hypercholesterolemia.


Large and small artery occlusion in diabetics and nondiabetics with severe vascular disease.


The ultra low frequency force ballistocardiograph in acute cardiomyopathy.


Regression of corpora lutea and interruption of pregnancy in rabbits following treatment with rabbit serum to ovine LH.


Effects of triiodothyronine and aldosterone on water and electrolyte excretion by the hypophysectomized rat.


Symposium on animal models in the study of gastrointestinal diseases of man. Comparative gastroenterology in veterinary medicine: an introduction.


Reflex and electromyographic abnormalities associated with fecal incontinence.


Granulomatous colitis of boxer dogs: comparative aspects.


Secretion of bile in response to food with and without bile in the intestine.


Intestinal disaccharidase deficiency in the sea lion.


Gastric and hematological abnormalities in a vegan with nutritional vitamin B 12 deficiency: effect of oral vitamin B 12.


Toxic dilation complicating Crohn's disease of the colon.


Effect of ligation of the pancreatic duct on the absorption of radio iron by rats.


Lactic, pyruvic, citric, and uric acid and urea content of human gastric juice.


Intestinal lactase deficiency and saccharide malabsorption during oral neomycin administration.


Inhibition of intestinal motility in man by glucagon given intraportally.


Paradoxical intestinal inhibitory effects of staphylococcal enterotoxin.


Succinic thiokinase. V. Preparation of labeled substrates, their bindings to the enzyme, and isotope exchange studies.


Metabolic functions of myo-inositol. V. Utilization of glycine and serine in nucleotide and nucleic acid biosynthesis by inositol-deficient KB cells.


Metabolic functions of myo-inositol. VI. Impairment of amino acid transport in KB cells caused by inositol deficiency.


Mechanism of action of guinea pig liver transglutaminase. 3. The metal-dependent hydrolysis of p-nitrophenyl acetate; further observations on the role of metal in enzyme activation.


Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats.


Proton magnetic resonance spectra of porcine and bovine insulin and of the A and B chain of bovine insulin.


Further studies of amino acid transport by embryonic chick bone.


Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex.


Purification and characterization of component S of glutamate mutase.


Oxime reactivation of diethylphosphoryl human serum cholinesterase.


The thiol groups of fumarase.

The thiol groups of fumarase.


Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue.


Studies on the mechanism of action of 2-keto-3-deoxy-L-arabonate dehydratase. The participation of an enzyme-substrate Schiff base in a dehydration.


Deoxynucleotide-polymerizing enzymes of calf thymus gland. II. Properties of the terminal deoxynucleotidyltransferase.


The relation of spectral changes and tritium exchange reactions to the mechanism of tryptophanase-catalyzed reactions.


Molecular weight and subunit structure of tropomyosin B.


The biosynthesis of the 7-deazaadenine ribonucleoside, tubercidin, by Streptomyces tubercidicus.


Amino acid esters as inhibitors of growth and of aminoacyl transfer ribonucleic acid synthetases in Euglena and Astasia.


Biosynthesis of phytosphingosine. Hydroxylation of dihydrosphingosine.


Oxidative phosphorylation in fractionated bacterial systems. XXVII. The nature of nonheme iron in Mycobacterium phlei.


The enzymatic hydrolysis of methotrexate and folic acid.


Acetoacetic decarboxylase. Activation by heat.


Tryptophan pyrrolase of liver. II. The activating reactions in crude preparations from rat liver.


Tryptophan pyrrolase of liver. 3. Conjugation in vivo during cofactor induction by tryptophan analogues.


The isolation and identification of N-isovalerylglycine from urine of patients with isovaleric acidemia.


Effect of pH on the phosphorescence of tryptophan, tyrosine, and proteins.


Studies on the antigenic structure of ribonuclease. V. Dinitrophenylated ribonuclease.


A soluble 2,3-oxidosqualene sterol cyclase.


Location of the heme in horse heart ferricytochrome c by x-ray diffraction.


Cochlear problems in otosclerosis surgery.


Stapedectomy with polystrut and fat graft reconstruction--a survey and analysis of the results of 200 cases.


Hearing loss and Paget's disease.

Hearing loss and Paget's disease.


A further study on the temporary effect of industrial noise on the hearing of stapedectomized ears. at 4,000 c.p.s.


The cochlear geometry as a frequency analyser.


A syndrome of vertigo and salivary gland enlargement with observations on the aetiology of recurrent parotitis.


Persistent stapedial artery: a temporal bone report.


Personal and family medical history in Menière's disease.


Treatment of a case of crocodile-tears by Vidian neurectomy.


Middle ear aspirator.

Middle ear aspirator.


Report from the Committee on Disaster Medical Care.


Jerome Cochran Lecture.

Jerome Cochran Lecture.


Clinical carbon dioxide-patient relationship.


Must you be God always?

Must you be God always?


Vietnamese, U. S.-medical educators meet with AMA.


"Facts on quacks" tells how to avoid the health swindler.


The role of the medical center in the education of health related personnel.


Medical education in the Congo: some factors in the use of nonindigenous faculty.


Molecular biology and practical medicine.


Manpower in the basic medical sciences.

Manpower in the basic medical sciences.


Nonintellectual components of medical education.


Datagrams: results of the National Intern Matching Program for 1967.


Studies on symmetrically conjoined twins.


Effect of arginine on serum levels of insulin and growth hormone in obese subjects.


Plasma free fatty acid response to exercise in obese humans.


Effect of a short period of cold exposure on plasma FFA level in lean and obese humans.


Liver and insulin: presence of insulin in bile.


Intravenous furosemide in diabetes insipidus.


Effect of furosemide on glucose metabolism.


Significance of changes in serum muramidase activity in megaloblastic anemia.


Annual report to the committee on publications.


Effect of saline infusions on aldosterone secretion and electrolyte excretion in normal subjects and patients with primary aldosteronism.


Pulmonary arterial webs. A new angiographic sign of previous thromboembolism.


Splenic scintiscanning in the preoperative diagnosis of subcapsular hematoma.


Reversion of left-bundle-branch block to normal conduction by carotid-sinus pressure.


Changing patterns and immutable aims.

Changing patterns and immutable aims.


Biopsy of skin--an underutilized laboratory "test".


Megaloblastic leukopenia.

Megaloblastic leukopenia.


Rheumatoid nodules simulating basal-cell carcinoma.


Conflicts and harmonies of normal stress. 1. Traumatic silence.


Arthrogryposis multiplex congenita.

Arthrogryposis multiplex congenita.


Let there be light.

Let there be light.


A history of the ICN 1899-1964; a review.


Salmonella; the multi-specious parasite.


What would you do if...

What would you do if...


The Hospital Centre: planning children's units.


The language of reports.

The language of reports.


A day in the life of Julia Warn: ward sister.


Nurse education in Scandinavia.

Nurse education in Scandinavia.


Mental confusion.

Mental confusion.


Caravan classroom.

Caravan classroom.


Colitis cystica profunda. A lesion of increasing significance to radiologists and pathologists.


Myelographic demonstration of lumbosacral nerve root avulsion.


Radiation therapy and wound healing delay. Animals and man.


The physiology of angiographic arterial waves.


Selective constriction of the profunda femoris as a postradiotherapy sequel. Report of a case.


Localized "radiation hepatitis" as demonstrated by scintillation scanning.


Modification of tumor microcirculation as an adjunct to hyperbaric oxygen in radiotherapy.


Conference to define the scope and content of research in diagnostic radiology. Held under the auspices of the National Institute of General Medical Sciences Bethesda, Md., Jan. 6, 1967. Preliminary report.


Evaluation of knee stability and stabilizing systems.


Localized aneurysms of the coronary arteries.


Vascular injury due to topical application of cardiovascular contrast medium in the hamster cheek pouch.


The inferior vena cava ligation and plication. A study of collateral routes.


The significance of webs in the hypopharynx and upper esophagus.


Evaluation of a radiographic survey method of upper gastrointestinal examinations. A preliminary study comparing fluoroscopic and radiographic examinations in 100 cases.


False filling defects in large gastric ulcers.


Delayed opacification of a common bile duct stone after intravenous cholangiography.


Effects of diagnostic x-rays on chromosomes in infants: a preliminary report.


Hereditary symphalangism associated with carpal and tarsal fusions.


Intervertebral disk calcification in childhood.


Iliopsoas bursal extension of arthritic disease of the hip.


A new era in mental health care: the comprehensive community mental health center.


The pathogenesis of the intestinal lesion of deep hypothermia and a proposed relationship to that of irreversible shock, including a note on a mechanism for the normal turnover of intestinal epithelium.


Post-traumatic changes in the internal carotid artery and its branches: an arteriographic study.


The techniques of side-to-side choledochoduodenostomy.


Solubilization method for centi-gram to kilo-gram plant samples. UCLA-12-613.


Ventricular septal defect. Unresolved problems.


Infection by Bedsoniae and the possibility of spurious isolation. 2. Genital infection, disease of the eye, Reiter's disease.


Studies on the effects of age on the central and peripheral isopters of the visual field in normal subjects.


The effect of exercise on intraocular pressure.


Restoration of the anterior chamber with glycerol 50 per cent and mydriasis.


Ruptures of descemet's membrane in keratoconus causing acute hydrops and posterior keratoconus.


Acute unilateral glaucoma associated with extradural hemorrhage.


A common epithelial foreign-body reaction to household chemical sprays.


Homocystinuria and ocular defects.

Homocystinuria and ocular defects.


Prevalence of myopia in Africans. Survey in Monrovia and Dar es Salaam.


Middlebrook-Dubos test in experimental ocular tuberculosis.


Lens organ culture. II. Pharmacologic evaluation.


Ocular autostimulation.

Ocular autostimulation.


Retinal vascular changes following exposure to high-intensity light.


Lens organ culture. I. Methodology and metabolic evaluation.


Surgery of pterygium by conjunctival pedicle flap.


Aphakic rehabilitation.

Aphakic rehabilitation.


Simplified goniophotography.

Simplified goniophotography.


Pterygium and its recurrence.

Pterygium and its recurrence.


A midget fascia stripper.

A midget fascia stripper.


Excision of the long segment of the optic nerve.


Nonexpulsive choroidal hemorrhage following cataract extraction.


Some relations among psychiatric symptoms, organic illness, and social class.


Current family structure. Psychiatric emergencies and patient fate.


Auditory elementary hallucinations in alcohol withdrawal psychosis.


Prognosis in schizophrenia. Prognostic scales crossvalidated in American and Norwegian patients.


How much psychiatry are medical students really learning?


The doctor-nurse game.

The doctor-nurse game.


Negro interviewers and white patients. The question of confidentiality and trust.


Adolescent psychiatry. An appraisal of the adolescent's position in contemporary psychiatry.


Hysterical personality traits. Psychological, social, and iatrogenic determinants.


Adolescent inpatients in love. A therapeutic contradiction.


A convenient accommodative target for near fixation.


Working class Mexican psychiatric outpatients. Some social and cultural features.


Psychological factors in ulcerative colitis.


Muscle tension and personality. A serious second look.


Renal colic.

Renal colic.


Pernicious anaemia among Asians in Singapore.


Asymmetrical rheumatoid arthritis after poliomyelitis.


Congenital melanosis oculi complicated by two independent malignant melanomas of the choroid.


Effects of rabies vaccine in man.

Effects of rabies vaccine in man.


Adverse reactions from the illicit use of lysergide.


Trephine biopsy for diffuse lung lesions.


Agranulocytosis coincident with amodiaquine therapy.


Inexpensive heat-exchanger system for the Rygg bag oxygenator.


Clinician's approach to respiratory viruses.


Oedema in pregnancy.

Oedema in pregnancy.


Segregation of tuberculosis patients.

Segregation of tuberculosis patients.


Local government reform and the health services.


Mediastinal emphysema.

Mediastinal emphysema.


The healing of wounds.

The healing of wounds.


Congenital dislocation of the hip: a review of adults treated in childhood.


Investigating hypertension.

Investigating hypertension.


Manometric study of the effect of vagotomy on the gastroesophageal sphincter.


The importance of the medial quadriceps expansion in medial ligament injury.


Lillehei CW: Effect of epsilon aminocaproic acid upon blood loss following open-heart surgery: an analysis of 340 patients.


Simultaneous and interval carcinomas of the colon and rectum.


Differential glucose tolerance: a method for determining portacaval shunt patency.


Post-traumatic arteriovenous fistula between the external carotid arteries and the superior longitudinal sinus: report of a case.


Intramedullary spinal cord metastasis: the sole clinical manifestation of an adenocarcinoma of the colon.


Twisted parovarian cyst in the puerperium: report of a case.


Elastogenesis in the cranial patagium of the wing of the chick.


A new method for measuring skin surface areas.


The role of elastic fibres in the periosteum in fracture healing in guinea pigs. I. Histological studies of the elastic fibres in the periosteum and the possible relationship between the osteogenic cells and the cells that form elastic fibres.


The open-condom urinary ileostomy device.


Elevation of thyrotropin release by intrapituitary infusion of crude hypothalamic extracts.


Stimulation by thyroidectomy and suppression by thyroxine administration of amino acid uptake by the rat pituitary gland.


Effects of theophylline on the serum calcium of rats after parathyroidectomy and administration of parathyroid hormone.


Effect of thyroactive materials upon mammary gland growth and lactation in rats.


Effect of calcium on cortisone-induced osteoporosis: a preliminary communication.


Effect of luteinizing hormone in vivo and in vitro on cholesterol conversion to progestins in rat corpus luteum tissue.


Desoxyribonucleic acid (DNA) synthesis in the radiated and stimulated thyroid gland.


Selective inhibition by progesterone of androgen-induced behavior in male ring doves (Streptopelia risoria).


Comparison of the carbohydrate and amino acid composition of bovine, ovine and human luteinizing hormone.


A bio-assay for parathyroid hormone in mice.


Effects of gonadotrophins in vitro on glucose uptake and lactic acid production of ovaries from prepubertal and hypophysectomized rats.


Host serum malic dehydrogenase activity associated with Trypanosoma lewisi infection.


Quantitative analysis of the chimaeric state in mice. I. Pattern of distribution of donor cells in the lymphoid organs of hosts neonatally inoculated with isologous spleen cells.


Quantitative analysis of the chimaeric state in mice. II. Cytological examination of the proportion of proliferating donor and host cells in runt disease in mice.


Studies on synthetic polypeptide antigens. XVII. Immunochemical properties of synthetic polypeptide-antibody systems.


Time of appearance and distribution of cells capable of secondary immune response following primary immunization.


Experimental delayed type allergy without demonstrable antibodies. I. Absence of cytophilic antibodies.


Alcoholism and the heart.

Alcoholism and the heart.


Pigmentary degeneration of the retina: early diagnosis and natural history.


Development of an objective psychological test for the determination of the coronary-prone behavior pattern in employed men.


Histamine formation in the tuberculin reaction of the rat.


Experimental delayed type allergy without demonstrable antibodies. II. In vitro activity of reticulo-endothelial cells.


Rehabilitating the chronically ill: a 5-yr. follow-up of 341 chronically ill ambulatory medical outpatients.