Kinetics of neutral amino acid transport in rat brain in vitro.


Increase in cholesterol along human optic nerve.


Protein incorporation and axoplasmic flow in motoneuron fibres following intra-cord injection of labelled leucine.


Lipid composition of myelin from the peripheral nervous system. Intradural spinal roots.


Early effects of a nerve growth factor on the RNA content and base ratios of isolated chick embryo sensory ganglia neuroblasts in tissue culture.


Ionic accumulation and membrane properties of enriched preparation of neurons and glia from mammalian cerebral cortex.


Triphalangeal thumb. A case report and evaluation of its importance in the morphology and function of the thumb.


The statistical relationship between the levels of serum cholesterol, beta-lipoprotein and phospholipids.


The tolerance of tissues to heat in vitro.


A dip into lux.

A dip into lux.


Medical education and general practice.

Medical education and general practice.


Antibiotic activity of gerrardine and cassipourine, alkaloids from plants of the family Rhizophoraceae.


Normal values for arterial blood pH carbon dioxide tension and content, at an altitude of 5,750 feet.


Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse. Mice infected with Plasmodium chabaudi obtained from two sources were found to be contaminated with Eperythrozoon coccoides. At each transfer of blood parasitized with plasmodia, eperythrozoa were also passed. In the presence of these organisms, the malarial infection assumed a low-level, chronic course infrequently resulting in death of the mice. When the eperythrozoa were eliminated through treatment with oxophenarsine hydrochloride, the malarial infection took an acute course always ending in death.


Phosphorylase b kinase inheritance in mice. The gene for phosphoryl ase b kinase, a skeletal muscle enzyme, has been located on the X chromo some of mice. The inheritance of the enzyme through two generations from original matings between one inbred strain of mice, the I, which lacks the enzyme, and another strain, the C(57,) follows the classical Mendelian pattern.


Voluntary hypothermia in reptiles.

Voluntary hypothermia in reptiles. Studies on lizards in laboratory thermal gradients which are not shut down at night reveal complex thermoregulatory behavior. Maintenance of the high, characteristic levels of body temperature known for active lizards may be abandoned. Low levels, which incapacitate the lizards, are seleted. Evidence of complex responses of the "thermostat" at a reptilian level of organization


Red cell slip at a wall in vitro.

Red cell slip at a wall in vitro. Interferometric microscope observations of flowing blood indicate that the absolute number of red cells maintaining sliding contact with a wall is of the order 10(4) per square centi meter at low flow rates. Contacting cell oscillation and orientation results are given. The near wall local hematocrit is found to be relatively low.


Fast light-evoked potential from leaves. When a leaf is illuminated with an intense flash of light, an elec trical response with a time course in milliseconds can be recorded. This re sponse was obtained between two wick electrodes placed at different positions on top of the leaf, with the entire leaf uniformly illuminated by the flash. During the first millisecond or so, the electrode nearer the apex of the leaf always became negative with respect to an electrode at the base, which indi cates that the voltage-generating source is fixed longitudinally in the leaf.


Isolation of 2,6-dibromophenol from the marine hemichordate, Balanoglossus biminiensis. 2,6-Dibromophenol has been isolated from a luminous marine enteropneust, Balanoglossus biminiensis, found on intertidal beach areas at Sapelo Island, Georgia. This compound, responsible for the characteristic "iodoform-like" odor of these animals, is present in relatively large amounts; the estimated quantity per organism is 10 to 15 milligrams. Identity of the isolated substance as 2,6 dibromophenol is based on analyses of ultraviolet, infrared, and nuclear magnetic resonance spectra, mass spectrometry analysis, and on melting-point data.


Sulfur mustard and x-rays: differences in expression of lethal damage. Before or after treatment with sulfur mustard, simple changes in the incubation conditions of cultured Chinese hamster cells lead to changes as great as a factor of 6 in survival-curve slopes. With x-ray treatment, changes are similar but much smaller in magnitude. These results suggest that the modes of action of these agents are not entirely the same.


Competent chick ectoderm: nonspecific response to RNA. Presumptive chick neuroectoderm responds to RNA from brain and heart by forming neural tubes, but it does not respond to liver RNA. This dif ferential response can be correlated with the presence of Folin-positive material in those RNA preparations which elicit the formation of neural structures.


Adaptation of an insect cell line (Grace's Antheraea cells) to medium free of insect hemolymph. Cultures of the insect cell line derived by Grace from Antheraea eucalypti Scott [Austrocaligula eucalypti (Scott)] were successfully adapted to medium supplemented with fetal bovine serum, whole-egg ultrafiltrate, and bovine plasma albumin instead of insect hemolymph. Cells, now in their 37th passage, have a population doubling time of 2.5 days; those of unadapted cultures, 4.2 days.


Single fibers of cat optic nerve: "thresholds" to light. Absolute thresholds of 39 single fibers of the optic nerves of 20 cats were determined by inspection of post-stimulus time histograms, each com puted from the responses to 60 to 100 identical flashes of white light. The values found-from 1.1 x 10(-7) to 6.8 x 10(-6) candella per square meter (nits)-agree well with psychophysi cal thresholds found in previous in vestigations.


Acetylcholine receptor: similarity in axons and junctions. Sulfur and selenium iso logs of benzoylcholine and its tertiary analog differ greatly in their abilities to block the electrical activity of squid axons. Presumably, differences in the biological activities of these compounds can be correlated with differences in their electron distribution. The relative effects on axons parallel those on junc tions of the electroplax, suggesting the presence of similar receptors.


Ribonuclease activity in normal and opaque-2 mutant endosperm of maize. Three strains of maize heterozygous for the opaque-2 mutant gene were self-pollinated to produce ears bearing both normal and opaque kernels. The ribonuclease activity of the opaque-2 endosperm was two to more than four times as high as the activity in the normal endosperm.


Ribonuclease activity in the developing seeds of normal and opaque-2 maize. During development, the ribonuclease activity of maize endo sperm homozygous for the opaque-2 gene increased earlier and, after a longer period of exponential increase, was much higher finally than in normal endosperm. The maximum difference was about sixfold and occurred 22 to 25 days after pollination. Heterozygotes on day 23 did not show a comparable in crease in endosperm activity. No differ ence in the activity ratio (pH 6.0: pH 5.2) was found between normal and opaque-2 endosperm, indicating that the increase in activity in opaque-2 was due solely to an increase in ribo nuclease A. The ribonuclease activity of opaque-2 embryos increased more rapidly than that of normal embryos, but the final activity was the same in each case.


Tetrodotoxin blocks a graded sensory response in the eye of Limulus. The generalization that tetrodotoxin selectively blocks all-or none electrical activity of nerve and muscle but has negligible effect upon graded responses of sensory systeins does not appear to be valid for the Limulus eye. Tetrodotoxin reversibly blocks the graded transient component of this visual response, while the steady state component of the response is rela tively unaffected by the drug.


Voluntary control of microsaccades during maintained monocular fixation. A contact-lens technique was used to record eye movements made by two subjects instructed either to "fixate" stationary white-light targets or to "hold" their eyes in position in the presence of the same targets. A marked reduction in saccade rate, frequently reaching zero throughout 9.8-second trials, was observed under the "hold" instruction.


Learning-set formation by mink, ferrets, skunks, and cats. The ability of mink, fer rets, skunks, and cats to learn to dis criminate between objects was com pared. Performance of mink and fer rets was similar to that reported for primates. This observation suggests that there is considerable overlap among mammals in ability to form learning sets.


Progressive systemic scleroderma in a child: a case report.


Heredity and endometrial carcinoma.

Heredity and endometrial carcinoma.


Treatment of skin cancer.

Treatment of skin cancer.


A rational approach to the management of hiatal hernia.


Continuing education for all of us.

Continuing education for all of us.


Primary intracranial neoplasms with extracranial metastases: a report of two cases.


Four separate carcinomas in the same patient: a case report.


Medical grand rounds from the University of Alabama Medical Center.


Exchange transfusion in the treatment of acute liver failure: a preliminary report.


Conditioning factors in allergic disease.


Amebic liver abscess.

Amebic liver abscess.


Premature closure of the proximal tibial epiphysis following fracture of the tibial shaft.


Missed diagnosis and von Domarus.

Missed diagnosis and von Domarus.


Juvenile diabetes: controlling the disease and the patient.


The decision making process in leadership.


Communication--within the organization.

Communication--within the organization.


Evaluating the effectiveness of an organization.


Motivation and the nurse.

Motivation and the nurse.


The thrust-demand of excellence.

The thrust-demand of excellence.


Executive decision for health.

Executive decision for health.


Evolutionary and historical changes in dietary carbohydrates.


Dietary carbohydrates in hyperlipemia (hyperglyceridemia); hepatic and adipose tissue lipogenic activities.


Effect of dietary carbohydrate on the glucose tolerance curve in the normal and the carbohydrate-induced hyperlipemic subject.


Comparison of effects of fructose, sucrose, glucose, and starch on serum lipids in patients with hypertriglyceridemia and normal subjects.


Dietary carbohydrate and fat, serum lipoproteins, and human atherosclerosis.


Some metabolic changes induced by low carbohydrate diets.


Dietary fats and carbohydrates, blood lipids, and coronary heart disease.


Carbohydrate and the United Kingdom food manufacturer.


Dietary carbohydrate and serum triglycerides.


Dietary carbohydrates and serum cholesterol.


Dietary carbohydrates in normolipemia.

Dietary carbohydrates in normolipemia.


Effect of bread in the diet on serum cholesterol.


Dietary carbohydrates and low cholesterol diets: effects on serum lipids on man.


Consumption of carbohydrates in the United Kingdom.


Regional variations in carbohydrate consumption in Czechoslovakia.


Carbohydrate absorption in malnourished children.


Effect of carbohydrate ingestion in humans on intracellular lipid deposition in tissue culture.


Effect of acute pericardial tamponade on coronary blood flow.


Role of the kinins in vasodilatation of skeletal muscle of the dog.


Endogenous histamine formation and vascular reactivity.


Effects of major cations on gastric and mesenteric vascular resistances.


Pressure-flow relationships in isolated dog colon.


Changes in electrolytes, pH, and pressure of blood perfusing isolated dog brain.


Ranges of heart rates and their regulations at various ages (rat).


Metabolism of glucose by the ischemic dog heart.


Heart rate and paired ventricular stimulation: effects on contractile force and K+ exchange.


Propagation velocity of transient aortic pulses.


Effects of some divalent cations on frog twitch muscles.


Effects of acute acidosis on renal hemodynamics.


Measurement of renal function in the rat with single injection clearances.


Electrical nature of active chloride transport across short-circuited turtle bladders.


Effects of mercurial diuresis and acute sodium depletion on renin release in dog.


Species specific activation of plasminogen: comparison of human urokinase and cat urine.


Heterogeneity in turnover of triglycerides in serum lipoproteins of the dog.


Glucose metabolism and plasma insulin level during epinephrine infusion in the dog.


Zinc content and subcellular distribution in red vs. white porcine skeletal muscle.


Mammary respiration in lactating goats.

Mammary respiration in lactating goats.


Intestinal transmucosal fluxes of bicarbonate.


The premedical education of the first-year class in Canadian medical schools: 1965-66. The premedical academic records of the 1965-66 entering class of Canadian medical students were analysed. Ninety-six per cent of the class had taken their preparation in a Canadian institution, while 80% had taken it in the same university as the medical school in which they enrolled. Forty per cent entered without a degree, the remainder having at least a bachelor's degree in arts or science.Thirty-six per cent of all courses taken by these students in their premedical education were in the physical sciences, 22% in the biological sciences and 41% in the social sciences and humanities. One-third of the students had taken no course in the behavioural sciences and another third had taken only one course.Analysis of the level of performance of the entering class showed that 10% had obtained an A average, 49% a B average, 41% a C average and 3% a D average. The grades of these students were higher generally in the natural sciences than in the social sciences or humanities.It was concluded that it could be questioned whether medical students received a premedical preparation which met the philosophy of a "broad, liberal education".


Medical education. II. Medicine or science--a study of career decisions. A study of the career decisions of all students in a single matriculation cohort was undertaken in 1965 at the University of British Columbia. Studied were 64 premedical students, 112 ex-premedical students and 87 science students who had completed at least their second year. It was found by means of a questionnaire that medicine remained the career of high prestige for the three groups of students. In general the values and needs of the ex-premedical student were more similar to those of the science student than the premedical student. The loyalists to medicine were found to be more committed, self-assured, and orientated towards people and service. In addition, the premedical student was more concerned about his academic achievement but was also more confident of his progress. He emerged at the end of his training as the committed student who had chosen medicine at an early age and had remained loyal to his chosen career goal.


The role of a tutorial system in undergraduate medical education. A tutorial system for first- and second-year medical students is now in its third year of operation at McGill University. The program was designed to meet the specific needs of McGill students. The aims and objectives were intentionally defined in a general way, application of detail being the responsibility of individual tutors and their groups of students. The main purpose of the program is the repeated exposure of students to the individual competence of outstanding teachers. A large majority of students and tutors favour the program. It has provided faculty members with insight into some of the problems of present-day medical education. The consensus is that, in the Faculty of Medicine at McGill University, the tutorial system serves an important role, complementing the normal curriculum.


A new school of medicine is born in Quebec. The new Faculty of Medicine at the University of Sherbrooke accepted its first 32 students in September 1966. The four major objectives of the school are: (1) medical education with emphasis on learning rather than teaching; (2) research in three major fields of endeavour: basic, clinical and medico-social sciences; (3) optimum patient care; and (4) service to society. A new Health Sciences Centre houses the Medical School, 1 420-bed hospital and multidisciplinary laboratories, and eventually will contain the paramedical schools, including a School of Nursing Sciences. The three major divisions of the Faculty are basic, clinical and medico-social sciences. The curriculum of the first two years is correlated and integrated within the "block" system, with participation from all three divisions.


Family practice: a proposed solution to the problem of meeting the medical needs of the community. Difficulties in meeting today's community medical needs are outlined, followed by a proposed solution in which the first-contact physician is the trained family physician. The McMaster Family Practice Course is described. The potential research contribution of a Department of Family Medicine is stressed.


A taxonomy of continuing medical education endeavour. Five basic forms of continuing educational endeavour by physicians are listed in rank order. These components constitute an indivisible unit bound together by self-learning. The scholarly habit of planned daily reading and study in a home library-sanctuary as an integral part of a physician's workday heads the list. Day-to-day informal and formal colleague-association in patient care in the community and teaching hospital, in group practice and by consultation is the present major form of continuing educational endeavour. Emphasized is the sabbatical return every three to five years for three months at least to the teaching hospital to reinforce scholarly motivation and attitudes and to acquire new skills and knowledge. Attendance at scientific sessions of learned professional societies and short courses should be accompanied by presession and post-session guided reading to be undertaken in the physician's home library-sanctuary.


Northern health service in Canada.

Northern health service in Canada. The current state and future development of Canada's North present significant medical problems. The medical facilities available at present are inadequate and, although they are improving rapidly, they must keep pace with the coming expansion of the North. Arctic regions of other northern countries do not show the great discrepancies in health standards that Canada's North does in comparison to her southern areas. To improve the situation adequate communication, transportation, personnel and facilities are needed. It is proposed that residents in hospital training programs work for a period in the North to supplement recommendations of the Hall Commission in this connection and to broaden their own training.


Alberta northern field work, 1966: rheumatic heart disease in LaCrete and Paddle Prairie. A sociologic and medical study was undertaken of the incidence of rheumatic heart disease in an isolated Mennonite colony in Northern Alberta, Canada. A group of Métis in a nearby settlement was used as a control. A total of 1294 individuals were examined, and evidence of carditis was found in 42 Mennonites.This project is one of a series of student summer research programs sponsored by the Department of Community Medicine, University of Alberta, and supported by grants from the Provincial Department of Health during the past three summers.The students - medical and dental - receive in Edmonton a seven- to 10-day orientation and indoctrination course dealing with the sociological, anthropological and medical problems likely to be met with in the North. Research protocol and methodological techniques are prepared and devised with student participation. A minimum of supervision is given in the field to encourage the undergraduates to adapt and adjust to a changed environment. Student response to this type of learning experience has been most encouraging.


The new Flexners.

The new Flexners.


Antileptospiral activity of serum. II. Leptospiral virulence factor. A definite relationship exists between the resistance of leptospires to the antibody-complement system and virulence. Leptospires capable of producing either lethal or renal infections in hamsters or guinea pigs were resistant to the leptospiricidal action of antibody and complement. Avirulent leptospires, in contrast to the virulent organisms, were rapidly immobilized and killed by these serum substances. The change of a virulent culture to the avirulent state as a result of growth in culture media was accompanied by the loss of resistance to antibody and complement. Virulent leptospires were phenotypically altered when grown in the presence of the purine analogue, 8-azaguanine. The cells became sensitive to antibody and complement without a corresponding decrease in virulence. The basis for a leptospiral virulence factor, the ability to multiply in vivo, appears to reside in their capacity to resist the leptospiricidal activity of the host antibody-complement system. The immune leptospiricidal assay provides a simple and rapid method of determining the virulence of a culture.


Lysostaphin in experimental renal infections. By use of a renal staphylococcal infection model in mice, single intravenous doses of lysostaphin ranging from 1.56 to 50 mg/kg were effective in: (i) controlling the staphylococcal population of kidneys, (ii) reducing the mortality rate, and (iii) clearing high numbers of kidneys of infection. Semisynthetic penicillins and other antistaphylococcal antibiotics given in the same manner did not have significant activity. Only by the administration of a long-acting, depot form of penicillin (Bicillin) could results comparable to those seen with lysostaphin be obtained. The results of this study suggest that lysostaphin may be useful in staphylococcal septicemias in preventing the establishment of new foci of infection.


Identification of staphylococcal hemolysins by an electrophoretic localization technique. A technique for identifying and characterizing staphylococcal hemolysins by first separating them electrophoretically in barbital-buffered agar gel (pH 8.4) at 5 ma/cm for 2 hr and then determining their hemolytic activities by exposing them to human, horse, rabbit, and sheep erythrocytes is described. The alpha-hemolysin produced by a White variant of the Wood 46 strain of Staphylococcus aureus migrated 18 mm towards the cathode, and it lysed horse, rabbit, and sheep erythrocytes, whereas a Clear variant of the Wood 46 strain of S. aureus produced a lysin which migrated similarly to the alpha-hemolysin but lysed only rabbit cells. This latter lysin was tentatively named alpha(1)-lysin. This strain of S. aureus also produced beta-hemolysin which migrated 36 mm towards the cathode and lysed sheep cells. beta-Hemolysin produced by some strains of S. aureus showed considerable tailing during electrophoresis, whereas beta-hemolysin produced by other strains of S. aureus migrated as a well-defined peak. A lysin migrating 11 mm towards the anode was probably delta-lysin. It was, however, not produced in sufficient concentration when the cultures were grown in semisolid medium.


Pathway of glucose fermentation in relation to the taxonomy of bifidobacteria. Cell-free extracts of 17 strains of Bifidobacterium bifidum (Lactobacillus bifidus) were examined for the presence of aldolase, glucose-6-phosphate dehydrogenase, and fructose-6-phosphate phosphoketolase. All strains turned out to lack aldolase, an enzyme unique to glycolysis, and glucose-6-phosphate dehydrogenase, characteristic of the hexosemonophosphate pathway. In all strains, fructose-6-phosphate phosphoketolase could be demonstrated. It can be concluded that bifidobacteria ferment glucose via a pathway which is different from those found in members of the genus Lactobacillus. The results strengthen the previous suggestions that classification of the bifidobacteria in the genus Lactobacillus is not justified.


Early functional mutants of . . . coliphage lambda. The early functional mutants of lambda, belonging to cistrons N, O, and P, are known to be blocked prior to vegetative multiplication of the lambda genome. Superinfection of heteroimmune defective lysogens by these mutants failed to elicit the function required for replication of the superinfecting phage. The mutants among themselves also showed poor cooperation on a nonpermissive host. Studies on the effects of different multiplicities of infection for bacterial lysis showed identical responses for mutants of different cistrons.


Metabolism of thiosulfate and tetrathionate by heterotrophic bacteria from soil. Two heterotrophic bacteria that oxidized thiosulfate to tetrathionate were isolated from soil. The enzyme system in one of the isolates (C-3) was constitutive, but in the other isolate (A-50) it was induced by thiosulfate or tetrathionate. The apparent K(m) for oxygen for thiosulfate oxidation by A-50 was about 223 mum, but, for lactate oxidation by A-50 or thiosulfate oxidation by C-3, the apparent K(m) for oxygen was below 2 mm. The oxidation of thiosulfate by A-50 was first order with respect to oxygen from 230 mum. The rate of oxidation was greatest at pH 6.3 to 6.8 and at about 10 mm thiosulfate, and it was strongly inhibited by several metal-binding reagents. Extracts of induced A-50 reduced ferricyanide, endogenous cytochrome c, and mammalian cytochrome c in the presence of thiosulfate. A-50, once induced to oxidize thiosulfate, also reduced tetrathionate to thiosulfate in the presence of an electron donor such as lactate. The optimal pH for this reaction was at 8.5 to 9.5, and the reaction was first order with respect to tetrathionate. There was no correlation between the formation of the thiosulfate-oxidizing enzyme of A-50 and the incorporation of thiosulfate-sulfur into cell sulfur. Thiosulfate did not affect the growth rate or yield of A-50.


Keto acids as growth-limiting factors in autotrophic growth of Thiobacillus thiooxidans. When the strictly autotrophic bacterium Thiobacillus thiooxidans was grown on sulfur, keto acids accumulated in the medium until they reached an inhibitory level at which growth ceased. Much greater growth was possible if these substances were continually dialyzed out of the medium.


Mechanism of fumaric acid accumulation in Rhizopus nigricans. It is doubtful that the glyoxylate bypass plays a significant role in the accumulation of fumaric acid by fungi, as has been postulated. In high glucose media, which favor fumarate production, isocitrate lyase (threo-D(s) isocitrate glyoxylate lyase), which is the key enzyme of the glyoxylate bypass, is strongly repressed. The specific activity of this enzyme remains low as long as glucose is present in the medium, even though fumarate formation proceeds at a high level. In addition, the activity of isocitrate lyase is inhibited by phosphoenolpyruvate, which would be formed from glucose. Alternatively, evidence is presented that bulk accumulation of fumaric acid under aerobic conditions in high glucose media takes place through a C(3) plus C(1) carbon dioxide fixation. CO(2) fixation was measured by the direct incorporation of NaHC(14)O(3) into fumaric acid, and by demonstrating that the specific radioactivity of fumaric acid formed from uniformly labeled C(14)-glucose was decreased in the presence of nonradioactive carbonate. The extent of decrease in specific radioactivity is in accord with a C(3) plus C(1) CO(2) fixation mechanism.


Synthesis of saturated long chain fatty acids from sodium acetate-1-C14 by Mycoplasma. Three strains of Mycoplasma, M. laidlawii A and B, and Mycoplasma sp. A60549, were grown in broth containing sodium acetate-1-C(14). The methyl esters of the phospholipid fatty acids of harvested radioactive cells were prepared and identified by comparison of their mobilities to known radioactive fatty acid methyl esters by use of a modified reversed-phase partition-thin layer chromatographic technique. No radioactive methyl oleate or methyl linoleate was detected. Compounds migrating as radioactive methyl myristate, stearate, palmitate, and, with less certainty, laurate and octanoate were detected. The qualitative findings for all three organisms appeared similar. M. laidlawii B synthesized a radioactive substance, presumably a saturated fatty acid detected as the methyl ester derivative, which migrated in a position intermediate to methyl myristate-1-C(14) and methyl palmitate-1-C(14). This work indicates that M. laidlawii A and B and Mycoplasma sp. A60549 are capable, in a complex medium containing fatty acids, of synthesizing saturated but not unsaturated fatty acids entirely or in part from acetate.


Bacterial oxidation of 2-tridecanone to 1-undecanol. A study of the microbial utilization of long-chain methyl ketones was under-taken. In general, enrichment culture experiments revealed that soil microorganisms capable of utilizing these compounds as growth substrates are ubiquitous. Gram-negative, rod-shaped bacteria were the prominent organisms exhibiting this capability. In particular, a strain of Pseudomonas isolated from soil degraded 2-tridecanone into several products that were recovered from cell-free culture fluid. These products were identified by gas-liquid chromatography as 2-tridecanol, 1-undecanol, 1-decanol, and undecanoic acid. A large amount of the substrate was converted to 1-undecanol. This compound was characterized further by classical methods of organic analysis. Unequivocal identification of 1-undecanol has established that some unique mechanism that involves subterminal oxidation must exist to degrade 2-tridecanone. No such mechanism has been reported for the biological degradation of long-chain, aliphatic, methyl ketones. A pathway for utilization of 2-tridecanone was proposed that is consistent with, but not confirmed by, the data presented.


Carbon catabolism and synthesis of macromolecules during spore germination of Microsporum gypseum. Either d- or l-leucine (10(-3)m) and unsaturated long-chain fatty acids such as oleic, linoleic, and arachidonic (10(-4)m) significantly stimulated macroconidia germination of Microsporum gypseum. Saturated long-chain fatty acids did not affect germination, whereas saturated short-chain fatty acids such as caprylic, hexanoic, and butyric were completely inhibitory. Germination was followed by an increase in endogenous respiration and a decrease in dry weight of approximately 5% at 4 hr. Endogenous fatty acids and soluble carbohydrates were utilized significantly during germination. Tritiated leucine, uridine, and thymidine were incorporated respectively into protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA) fractions within the first 5 min of germination. Incorporation of oleic-1-C(14) into RNA and protein was significantly increased after germ tube development. Net synthesis of RNA and protein started prior to germ tube protrusion. Increase in DNA could be detected only later. A significant increase in RNA and protein during the 4th hr of germination was correlated with vegetative development. Inhibition of respiration and incorporation of leucine-H(3) and uridine-H(3) into corresponding macromolecules by dl-fluorophenylalanine and phenethyl alcohol started before germ tube appearance. Griseofulvin significantly inhibited incorporation of uridine-H(3) and thymidine-H(3), but not of leucine-H(3). This inhibition occurred only after initial vegetative development. In contrast to the two other inhibitors, which substantially inhibited germination, griseofulvin only slightly retarded the period of germination and did not affect respiration.


Morphology and reproductive processes of the L forms of bacteria. I. Streptococci and staphylocci. The production of L forms from cocci, the conditions necessary for their multiplication, and their morphology have been studied for several years. In each strain studied, only a few organisms produced L forms. Transplants from these grew poorly at first, and growth on agar and in broth became abundant only after long cultivation. Multiplication in the form of small granules was observed only when the organisms were embedded in agar and occasionally in coagulated blood serum. On the surface of hard agar, the organisms increased in size but did not multiply. Abundant growth developed on membrane filters of appropriate size, extending into the filters as branching irregular masses. On gelatin, on most samples of coagulated serum, and on silica gel, the organisms grew to a very large size, and occasionally colonies developed by multiplication of large bodies. This multiplication occurred by irregular enlargement and separation into fragments. Growth in broth and in semisolid agar also occurred by multiplication of large bodies, but, in addition, the development of viable granules was observed inside the large bodies in broth culture. After the L forms began to grow abundantly, their nutritional requirements were simple; they no longer required animal serum. Their ability to multiply and their morphological characteristics depended to a large extent on the physical properties of the environment.


Occurrence of isocitrate lyase in a thermophilic bacillus species. A thermophilic, sporeforming bacterium has been isolated from soil on a medium containing acetate as a carbon source. This organism is similar to Bacillus stearothermophilus in most respects but differs in its inability to hydrolyze starch. Isocitrate lyase is present in cell-free extracts of organisms grown in a medium with acetate as a carbon source. The specific activity was 400 times lower in extracts of organisms utilizing glucose as a carbon source. With crude extracts, enzyme activity was strongly stimulated by Mg(++), but cysteine and ethylenediaminetetraacetate had little effect. It appeared to be more heat-stable than the pure isocitrate lyase from Pseudomonas indigofera.


Properties of Mycoplasma hominis 4330.

Properties of Mycoplasma hominis 4330. Mycoplasma strain 4330, one of the earliest strains of pleuropneumonia-like organisms to be isolated from man in the United States, has been found to resemble M. hominis type 1 by serological methods (the growth inhibition and latex agglutination tests). The results of earlier serological studies indicated a similarity between the Campo and 4330 strains which was not detected by use of the cultures currently available. Strain 4330 differs from strains of Mycoplasma recently isolated from man by producing acid from a variety of carbohydrates. This acquisition of biochemical properties may be the result of hundreds of transfers on artificial media during a period of more than a quarter of a century. Identification of the strain was deemed advisable, since two different cultures and a mixed culture existed under the designation "4330." The extraneous organisms were found to be closely related to M. laidlawii by their biological and serological properties.


Use of tetrazolium salts for electron transport studies in meningopneumonitis. 3. Separation and examination of large and small particles. Purified suspensions of meningopneumonitis can be separated on potassium tartrate gradient into populations which are 80 to 90% large particles and those which are 90% small particles. Examination of the tetrazole reduction of both particle types indicates that the small particle has associated with it all of the enzymatic activity of the preparation; it also has associated with it most of the infectivity as well.


Phenocopies of a heteromorphous flageller mutant in Salmonella.


Properties of yeast cell ghosts obtained by ribonuclease action. Cell ghosts were obtained from Candida utilis and Saccharomyces cerevisiae by the action of some conformational isomers of pancreatic ribonuclease which passed through the cell wall and penetrated the cell membrane. In the interior, the enzyme caused extensive disorganization of the cellular structure as evidenced by the results of vital staining and electron microscopy. Ribonucleic acid was degraded to fragments that leaked out into the suspending medium. Other cytoplasmic constituents, including the amino acid pool, were released, but most of the cellular protein and deoxyribonucleic acid remained in the ghosts. The lesions in the cytoplasmic membrane were too small to be seen by conventional electron microscopy. The membrane clung to the cell wall even after obliteration of most of the intracellular structure.


Suppression of the primary and secondary immune response of the mouse by phytohemagglutinin.


Termination of acquired tolerance by administration of small lymphocytes.


The binding of naturally occurring anti-B isohemagglutinins to the B antigens of human erythrocytes.


Antibody responses in experimental infections with Listeria monocytogenes.


Anti-Pasteurella pestis factor from mice and guinea pigs. II. Some chemical and physical characteristics.


Heterogeneity and sequence of appearance of rabbit antibodies to hog intrinsic factor.


Immediate hypersensitivity reactions induced in mice by active and passive means.


Autoimmune haemolytic anaemia.

Autoimmune haemolytic anaemia.


Oesophageal atresia treated by elongation of both pouches and delayed primary anastomosis.


Paediatrics in Ireland to-day.

Paediatrics in Ireland to-day.


Vaccination against poliomyelitis using oral vaccine.


Foetal infections, with special reference to rubella.


Accident and emergency services in Dublin. A report by an I.M.A. committee.


A Child Psychiatric Unit in a General Teaching Hospital.


Pink Disease from cutaneous absorption of mercury.


Classical neonatal tetany. (Neonatal tetany of renal origin).


Renal vein thrombosis in the newborn.

Renal vein thrombosis in the newborn.


Chemoprophylaxis with penicillin. Prevention of infection in devascularized muscle.


Vitamin B12 absorption following oral administration in tumor-bearing rats.


Penicillamine and wound healing in young guinea pigs.


A method for vital microscopy of the hepatic microcirculation in large animals and man.


Electrical activity of the canine liver.


Peptic ulceration.

Peptic ulceration.


The effects of vagotomy and a drainage procedure on nutrition.


Water and electrolyte balance.

Water and electrolyte balance.


Early signs of mental illness. 1.

Early signs of mental illness. 1.


How drugs act--second series. 12. The safety of drugs.


Obstetric surgery. 3. Caesarean section.


Less nonsense about nutrition. 3.

Less nonsense about nutrition. 3.


Planning nurse training programmes; conference at The Hospital Centre.


Coxsackie heart disease in adults.

Coxsackie heart disease in adults.


Electrocardiographic characteristics of P pulmonale waves of coronary origin.


Variables affecting the splitting of the second heart sound in atrial septal defect.


Repeated venous and arterial catheterization in man. An analysis of complications.


Concealed digitalis-induced arrhythmias unmasked by electrical stimulation of the heart.


Vascular patterns in the canine sympathetic chain.


The hemodynamic effects of diphenylhydantoin.


Circulatory dynamics of paired pacing in hypovolemic and cardiogenic shock.


The effects of potassium on the positive inotropic action of ouabain.


The isolated systolic click with bacterial endocarditis.


Clinical pathologic conference.

Clinical pathologic conference.


Reappraisal of digitalis. 8. Digitalis dosage.


Changes in the natural history of hypertensive disease.


The natural history of cerebral berry aneurysms.


The long-term therapy of severe hypertension with guanethidine.


Completeness of gastric vagotomy by the selective technic.


Relation of antral pH to gastrin release and fundal pH in dogs.


Influence of route of administration on therapeutic ratio of atropine in sham-fed dogs.


Freezing of the intact rat stomach: an indication of the biologic potential of the technic.


Effects of in-vitro neutralization on the composition of the nondialyzable components of human gastric juice.


Late elevation in serum bromsulfalein in Dubin-Johnson syndrome. A comparative case study.


Cytologic diagnosis of cancer from aspirated material obtained at liver biopsy.


The clarity of good technic.

The clarity of good technic.


Commentary.

Commentary.


Lateral lung scanning, anatomic and physiologic considerations.


Selective cinebronchography in obstructive and restrictive pulmonary disease.


Nasal pressure changes during swallowing; an analysis of 1,219 swallows in 88 healthy subjects.


A comparison study of laryngography techniques. 150 KVP. plain roentgenography vs. positive contrast roentgenography.


Ureteral peristalsis in duplex renal collecting systems.


The excretory urogram in children with ureterorenal reflux.


Four phase nephrotomography in the diagnosis of renal cysts and tumors.


An evaluation of cobalt 60 rotational teletherapy equipment.


Survival following roentgenographic demonstration of gas in the hepatic portal venous system.


Hepatic portography by direct catheterization of the portal vein through the round ligament of the liver (ligamentum teres).


Rupture of the spleen: a new roentgen sign.


The spontaneous disappearance of gall stones.


Vanishing pancreatic calcifications. A case report.


Unilateral bullous emphysema. Angiocardiographic study of two cases.


Echinococcus disease. Report of 112 cases from Iran and a review of 611 cases from the United States.


A thin-wall double catheter system for transtracheal bronchography.


Compression of bladder due to "rheumatoid" cysts of hip joint.


Persistent vomeronasal organ.

Persistent vomeronasal organ.


The normal hypoglossal canal.

The normal hypoglossal canal.


Pycnodysostosis. Report of three new cases.


Craniometaphyseal dysplasia (Pyle's disease) in an ancient skeleton from the Mochica culture of Peru.


An unusual case of brachydactyly. Peripheral dysostosis? Pseudo-pseudo-hypoparathyroidism? Cone epiphyses?


Trabecular patterns in bone.

Trabecular patterns in bone.


The hand as an indicator of generalized disease.


Automation of film viewing--a new device--the panoramascope.


The effect of ischemia on nerve conduction.


Failure of acetylcholine to provoke release of material with acetylcholinelike activity from rat brain subcellular particles.


Effects of subthalamic stimulation on sensory-evoked potentials in the reticular formation and cortex.


Development of cortical electrical activity in the rat.


Learned and unlearned responses to stimulation of the same subcortical site.


Drug-induced dendritic sprouts on Purkinje cells in the adult cerebellum.


Selective destruction of precursors of microneurons of the cerebellar cortex with fractionated low-dose x-rays.


Evoked responses in the chicken telencephalon to auditory, visual, and tactile stimulation.


Alterations in growth of brain and other organs after electroshock in rats.


Brain-stem regions for stimulus-bound and stimulus-related respiration.


Effect of structural alterations on the photosensitizing potency of furocoumarins (psoralens) and related compounds.


Canadian experience with the Margulies spiral.


Disc electrophoretic studies of proteins from Coccidioides immitis.


An evaluation of immunologic factors of infertility. This paper reviews earlier studies identifying 3 possible immunologic causes of infertility:  autoimmunity, ABO blood group incompatibility, and isoagglutination, and presents results of recent studies, including an analysis of the incidence of isoagglutinations, autoagglutinations, and ABO incompatibility in a group of couples with unexplained primary or secondary infertility and couples with an organic cause of infertility; incidence of antibodies in postpartum women, women in early pregnancy, unmarried women, and prostitutes; the relationship between ABO incompatibility and/or sperm-agglutinating antibodies to postcoital testing of cervical mucus; results of condom therapy in couples with positive isoagglutinins; a comparison of hemagglutination test with the microagglutination test; and preliminary studies of the immunoglobulin responsible for a positive microagglutination reaction.  Results obtained from 292 women and 176 men indicated that in the 64 couples with primary unexplained infertility, 24 wives had isoagglutinins and 5 of the husbands had autoagglutinins.  Among 32 couples with secondary unexplained infertility, 16 wives had isoagglutinins and only 1 husband had autogglutinins.  50 couples with organic causes of infertility and 25 unmarried women had a 20% incidence of isoagglutinins.  Positive serologic reactions were found in 35 of 48 prostitutes.  15 of 44 women in the 1st trimester of pregnancy had isoagglutinins to at least 1 of 3-5 donor semen specimens, but serums of 7 of the women gave negative reactions when tested against the husband's ejaculate.  The 2 women in the group who aborted had negative antibody titers.  Only 1 of 29 serums from postpartum women gave positive agglutination reaction.  Among 68 couples, 19 subjects had positive microagglutination test reactions but only 7 had positive hemagglutination reactions.  No specific relationship was found between ABO incompatibility and the results of postcoital testing of cervical mucus in 58 women tested or positive circulating issoagglutinins in 62 women tested.  27 of 68 couples with primary unexplained infertility, 18 of 33 with secondary unexplained infertility, and 13 of 46 with organic causes of infertility had ABO incompatiblity.  Autoagglutination, unless massive, was not incompatible with pregnancy.  Circulating antisperm antibodies fell to undetectable levels after 2-12 months of condom therapy.  Careful timing of ovulation is essential because of the increase in antibodies after reexposure.  Results of condom therapy in terms of pregnancies were disappointing.


An electron microscopic observation of  Trichophyton violaceum.


The first stage in the natural history of the human scalp hair cycle.


Histopathology of lichen planus based on analysis of one hundred biopsy specimens.


The measurement of glutathione in human epidermis using glutathione reductase.


Induction of ovulation with human postmenopausal gonadotropin. 3. Effect of varying dosage schedules on estrogen and pregnanediol excretion levels.


Oral leukoplakia--studies in enzyme histochemistry.


Human fertility in Ghana.

Human fertility in Ghana.


Preparation and characterization of a viable suspension of postembryonic human epidermal cells.


Hormonal fertility control: a working hypothesis for population control.


Return of ovulation after discontinuance of oral contraceptives.


Purine and pyrimidine metabolism in human epidermis.


Regional variation in percutaneous penetration of 14C cortisol in man.


Ultrastructural changes in the horny layer following local application of dimethyl sulfoxide.


Asymmetric distribution of alkaline phosphatase activity in the hair and wool follicles of sheep.


Chronic solar dermatosis: a light and electron microscopic study of the dermis.


Enzymes of amino acid metabolism in normal human skin. I. Glutamate dehydrogenase.


Sulfhydryl content in subcellular fractions of mouse melanomas.


Thymine and uracil metabolism in the epidermis.


Outcome of pregnancy in patients with hereditary hemorrhagic telangiectasia. A retrospective study of 40 patients and 80 matched controls.


Lactate dehydrogenase patterns in verrucae vulgares, basal cell carcinomas and malignant melanomas.


Trichorrhexis nodsa--an error of amino acid metabolism?


A tensiometric analysis of epidermal healing in the plantar skin of guinea pigs.


Particles in the cisternae of the endoplasmic reticulum of Fortner's amelanotic and melanotic malignant melanomas.


A simple in vivo method for studying the permeability of the human stratum corneum.


The regulation of insulin secretion: effects of the infusion of glucose, ribose, and other sugars into the portal veins of dogs.


Allergic sensitization of plants (bean) to a simple chemical (copper sulfate).


Salt and water absorption from the normal human colon: effect of 9-alpha-fluorohydrocortisone administration.


Quantitative microanalysis of bile.

Quantitative microanalysis of bile.


Pool size and turnover of bile acids in six hypercholesteremic patients with and without administration of nicotinic acid.


Studies of the metabolism and distribution of fibrinogen in patients with rheumatoid arthritis.


Hydrocortisone induced changes in sugar nucleotide content of sponge biopsy connective tissue in the absence of comparable changes in the liver.


Immunologic studies of proteins associated with subcellular fractions of normal human platelets.


The mechanism of red cell aging. I. Relationship between cell age and specific gravity evaluated by ultracentrifugation in a discontinuous density gradient.


A semiautomatic one-stage factor 8 assay with a commercially prepared standard.


Intracellular Cl-, Na+, K+, Ca2+, Mg2+, and P in nervous tissue; response to glutamate and to changes in extracellular calcium.


Effect of dietary protein content on regional distribution of ascorbic acid in the rat brain.


Water content of developing kitten brain.


Entry of L-[14C]phenylalanine and alpha-amino[14C]isobutyric acid into the cerebrospinal fluid and brain of dogs.


Incorporation of peripherally administered riboflavine into flavine nucleotides in the brain.


A method of determination of homocarnosine and its distribution in mammalian tissues.


Incorporation of [1-14C]linoleate and linolenate into polyunsaturated fatty acids of phospholipids of the embryonic chick brain.


Inhibition of protein synthesis in Mauthner nerve fibre components by actinomycin-D.


Hydrolysis of nucleoside diphosphate esters in peripheral nerve during Wallerian degeneration.


Health aspects of safety.

Health aspects of safety.


Open bench-top deburring of metallic beryllium. A hygiene study with recommendations for a deburring station.


Mortality pattern in a cohort of asbestos workers. A study on employment experience.


Silicone in the treatment of burns of the hand.


A two-year study of myocardial infarction in industry.


Chlorine.

Chlorine.


Folklore and facts about employees with alcoholism.


Bronchitis and dermatitis in a machine operator and part-time farmer.


Production of a cigarette of lower temperature of combustion and its significance.


Initial experience with the Lopresti fibreoptic oesophagoscope.


Effects of iron-dextran infusion on veins.


Radon leakage from sealed radium sources in medical use.


Survey of the first year of a new clinic.


New hearts for old.

New hearts for old.


The Australian College of Dental Surgeons.


The Tasmanian Medical Practitioners' Fire Relief Fund.


Modification of latent diabetes by short-term phenformin administration.


Medical research Foundation OF Warringah.


Effect of pulse administration of glucose or glucagon on insulin secretion in vitro.


Urine insulin in normal subjects.

Urine insulin in normal subjects.


Comparison of insulin and 2-deoxy-D-glucose-induced glucopenia as stimulators of growth hormone secretion.


Metabolism of plasma glucose and lipids following diazoxide administration in dogs.


Effect of thyrotropin on carbohydrate and iodine metabolism in the perfused dog thyroid gland.


Estrogen-induced increase in phosphohexose isomerase activity in the rat uterus.


Citrate metabolism in diabetes. II. Tissue citrate content, citrate synthase and oxidation in alloxan-diabetic rat.


Carmine as a source of nosocomial salmonellosis.


Aortic stenosis in infants.

Aortic stenosis in infants.


Carpal-tunnel syndrome.

Carpal-tunnel syndrome.


Hospital-acquired salmonellosis traced to carmine dye capsules.


Hemodynamic alterations in congestive heart failure.


Evaluation of therapy in chronic, noninfectious nephropathies.


Case records of the Massachusetts General Hospital. Case 16-1967.


Doctors, hospitals, public welfare and "medicaid".


Accidental deaths in 1966.

Accidental deaths in 1966.


Determination of free thyroxine in serum of patients with cirrhosis of the liver.


Gamma-A deficiency and hypochromic anemia due to defective iron mobilization.


The trainee as a teacher in the community hospital.


Cirrhosis and free thyroxine.

Cirrhosis and free thyroxine.


Infectious complications of chemotherapy in a protected environment.


The community hospital in medical education.


Computerized librarianship.

Computerized librarianship.


Prenatal transfusion.

Prenatal transfusion.


Nephritis and the nephrotic syndrome.

Nephritis and the nephrotic syndrome.


We looked at ourselves.

We looked at ourselves.


Crush injuries of the chest. 3. Crush injuries: nature and causes.


Crush injuries of the chest. 1. Surgical treatment and nursing care.


Crush injuries to the chest. 4. The general management of chest injuries.


Crush injuries of the chest. 5. Chelmsford School of Nursing.


Comments on senior nursing staff structure (Salmon Report).


Early signs of mental illness. 2.

Early signs of mental illness. 2.


Drug dependency.

Drug dependency.


Social considerations of drug taking.

Social considerations of drug taking.


Drug addicts in a casualty department.

Drug addicts in a casualty department.


Bridge that gap: in-service training for newly-qualified staff nurses.


A day in the life of... John Hill, charge nurse.


Using our resources.

Using our resources.


Modern enema technique.

Modern enema technique.


Strangulated hernia with complications: a nursing care study.


Rcn to the rescue.

Rcn to the rescue.


Comparative anatomy of olfactory centres and tracts.


Protopathy, paraesthesia and sensory suppressor zones.


On the structure and fibre connections of the olfactory centres in mammals.


The Eisenmenger syndrome.

The Eisenmenger syndrome.


The surgical management of acute massive pulmonary embolism.


The 1965 influenza A2 epidemic in the USSR and antigenic analysis of isolated strains.


Demographic, clinical and survivorship characteristics of males with primary cancer of the breast.


Long-term immunity to diphtheria and tetanus: a mathematical model.


The antigenic heterogeneity of type 30 echoviruses.


Assessing the influence of treatment on the spread of staphylococci in newborn infants by simulation.


Report on a phantom epidemic of gonorrhea.


The treatment of squamous cell carcinoma of the head and neck with methotrexate and irradiation.


Pectus excavatum. Simple autogenous tissue support to keep sternum elevated.


Review of splenic artery aneurysms with an additional seven case reports.


Diagnostic laparotomy.

Diagnostic laparotomy.


Topical control of water loss from the body surface. I. Preliminary study.


Unusual arteriovenous fistulae involving hepatic artery, portal vein and internal iliac vessels: case reports and a review of the literature.


Idiopathic retroperitoneal fibrosis precluding splenorenal shunt.


Operative treatment of slipped capital femoral epiphysis.


Prosthetic heart valve surgery in acquired valvular heart disease.


Cerebral vascular insufficiency. Syndromes of reversed blood flow in vessels supplying the brain.


Carcinoma of the jejuno-ileum.

Carcinoma of the jejuno-ileum.


Surgical management of duodenal ulcer: emphasis on vagotomy and gastric drainage.


An evaluation of methyl 2-cyanoacrylate as a burn dressing.


Musculoplasty: a solution to the problem of chronic tympanomastoiditis.


Stimulation of secreting cell mass by submucosal lymph from gastric antrum in dogs.


Calcification of the mitral valve. Results of valvotomy in 100 cases.


The aetiology of renal stone: a new concept arising from studies on a stone-free population.


Mitral incompetence complicating acute myocardial infarction.


Clinical presentation of myocardial infarction in the elderly.


Acid-base balance in complete transposition of the great vessels.


Ageing changes in human heart valves.

Ageing changes in human heart valves.


Diagnostic applications of the platinum electrode catheter.


Early systolic sounds in aortic valve stenosis.


Reversed mitral diastolic gradient in aortic incompetence.


Effect of propranolol on left atrial systole in ischaemic and hypertensive heart disease.


Iatrogenic escape-capture bigeminy.

Iatrogenic escape-capture bigeminy.


Double outlet right ventricle with pulmonary stenosis.


An automatic fractionator for light dosage on the skin. Its application to the polychromatic minimal erythema dose.


Cardiac tamponade in constrictive pericarditis following cardiac catheterization.


An assessment of radiological criteria used in the study of spinal osteoporosis.


Pulmonary nodules in rheumatoid disease: a report of two cases.


Transitory hyperaemia in focal cerebral vascular lesions studied by angiography and regional cerebral blood flow measurements.


Dose assessment in diagnostic radiology.


Organ visualisation with technetium 99m preparations.


Angiographic recognition of diseases involving the spine.


An ectopic renal artery.

An ectopic renal artery.


A critical "dose-per-fraction" factor.

A critical "dose-per-fraction" factor.


A health corporation?

A health corporation?


2 years' admissions to a regional child psychiatry unit.


Amphetamine prescribing.

Amphetamine prescribing.


Acanthosis nigricans.

Acanthosis nigricans.


Specifications for eye-drops.

Specifications for eye-drops.


Pulmonary artery thrombosis and the nephrotic syndrome.


Enteroviruses and congenital abnormalities.


Proflavine and acriflavine.

Proflavine and acriflavine.


Prevention of pressure sores.

Prevention of pressure sores.


Simultaneous tubal and uterine pregnancy.


Poisoning with Mandrax.

Poisoning with Mandrax.


Venous leg ulcers.

Venous leg ulcers.


Locating the placenta.

Locating the placenta.


Treatment of haemophilia.

Treatment of haemophilia.


Glycosuria of pregnancy.

Glycosuria of pregnancy.


Human growth hormone.

Human growth hormone.


Drug-taking by the young.

Drug-taking by the young.


Growth response of 26 children with short stature given human growth hormone.


Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure.


Normal erythrocyte sedimentation rate and age.


Antihaemophilic globulin: preparation by an improved cryoprecipitation method and clinical use.


Controlled trial of demigran in the prophylaxis of migraine.


Delayed traumatic rupture of colon with colocutaneous fistula.


Cryoprecipitate and the plastic blood-bag system: provision of adequate replacement therapy for routine treatment of haemophilia.


New instrument for banding of the pulmonary artery for ventricular septal defect.


Proceedings of the International Symposium on Physical Activity and Cardiovascular Health held in Toronto, Ontario, October 11-13, 1966 and sponsored by the Ontario Heart Foundation, the Ontario Medical Association, and the Canadian Medical Association.


Circulating antibody response in BCG vaccination, tuberculous infection and sarcoidosis. The bentonite flocculation test was used to differentiate antibodies formed by BCG vaccination from those produced by infections with virulent tubercle bacilli. Of 116 BCG-vaccinated nurses, only two (1.7%) showed antibody titres higher (1:128) than the threshold titre of 1:64 established for tuberculous patients.The bentonite test was also used to follow the course of infection in 54 patients with tuberculosis. A good correlation was found between the clinical course of the disease and O.T.-bentonite titres on repeated serological testing.Tuberculosis-like antibodies were demonstrated in sarcoidosis patients. These antibodies, however, are globulins (7S), in contrast to the macroglobulins (19S) found in tuberculous patients.


Cardiorespiratory determinants of cardiovascular fitness.


Muscular factors which determine the cardiovascular responses to sustained and rhythmic exercise.


The influence of nutrition.

The influence of nutrition.


Psychological determinants of fitness.

Psychological determinants of fitness.


Ischemic heart disease, heredity and body build as affected by exercise.


Measurement of maximal aerobic capacity.


Submaximal tests for estimating maximum oxygen intake.


The testing of cardiac patients.

The testing of cardiac patients.


The influence of active conditioning upon subjects with coronary artery disease: cardiorespiratory changes during training in 67 patients.


Muscular factors.

Muscular factors.


Aerobic capacity and external criteria of performance.


Psychological changes with physical fitness training.


Anaerobic metabolism in muscle.

Anaerobic metabolism in muscle.


Some comments on changes in body composition. Commentaries.


Lactate and related acid base and blood gas changes during constant load and graded exercise.


The physiological stimuli to training in a normal climate.


Some comments on exercise and changes in blood chemistry.


Training, acclimatization and heat tolerance.


The effect of physical training with and without cold exposure upon physiological indices of fitness for work.


Population studies.

Population studies.


Habitual level of physical activity and risk of coronary heart disease: the Framingham study.


Participation in athletics.

Participation in athletics.


Heart disease in farm workers.

Heart disease in farm workers.


Ethnic group differences in fitness for sustained and strenuous muscular exercise.


Physical activity and the "rate of ageing".


Occupational factors in the study of coronary heart disease and physical activity.


Hemodynamic and metabolic effects of physical training in four patients with essential hypertension.


Physical activity and psychic stress/strain.


Physical activity and the coronary circulation.


Exercise, food intake and health in experimental animals.


Current levels of fitness.

Current levels of fitness.


Activity patterns in the community.

Activity patterns in the community.


Motivation for sports participation in the community.


Optimum patterns of exercise for healthy adults.


The influence of active conditioning upon subjects with coronary artery disease: a progress report.


Vasoregulatory asthenia.

Vasoregulatory asthenia.


Proceedings of the International Symposium on Physical Activity and Cardiovascular Health. Concluding remarks.


Proceedings of the International Symposium on Physical Activity and Cardiovascular Health. Glossary of specialized terms and units.


Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney.


Delayed hypersensitivity in mice to dextran.


Unique acid-base parameters of gastric venous blood during secretory activity.


Viral hepatitis in a group of Boston hospitals. 3. Importance of exposure to shellfish in a nonepidemic period.


Studies on the experimental alteration of water and electrolyte composition of the eel (Anguilla anguilla L.).


Concurrence of cystathioninuria, nephrogenic diabetes insipidus and severe anemia.


Case records of the Massachusetts General Hospital. Case 14-1967.


The challenge of surgery in an era of confusion.


Internal temperature of steamed clams.

Internal temperature of steamed clams.


Cave molluscas.

Cave molluscas.


Ungentle rain from heaven.

Ungentle rain from heaven.


Fire-resistant garments.

Fire-resistant garments.


Laboratory service for influenza and other respirovirus diseases.


Topical therapy of burns: experimental evaluation.


The bulbous nose.

The bulbous nose.


Silicone immersion in the care of burns.


Investigation of congenital malformations of the ears with tomography.


Metacarpal transplant and joint reconstruction following a power mower injury.


Surgical tattooing: an experimental study. I.


Physiologic and environmental monitoring of manned space flights.


A spring wire clip for fixation of naso-orbital fractures.


The digital Allen test.

The digital Allen test.


Mammographic screening for breast cancer.


Tracheal dynamics in infants with respiratory distress, stridor, and collapsing trachea.


Skin doses from glass and beryllium window x-ray tubes in mammography.


Appraisal of coronary arteriography in evaluating the hemodynamic significance of experimental coronary artery stenosis.


Pulmonary hypertension: an angiographic study.


The epinephrine effect in angiography of gastrointestinal tract tumors.


Misleading appearances in renal angiography.


Scintillation camera renography in the study of prolonged renal transit time.


Pseudotumors of kidney secondary to anticoagulant therapy.


Scanning bremsstrahlung of yttrium-90 microspheres injected intra-arterially.


Anomalous cephalic venous drainage in association with aneurysm of the great vein of Galen.


Peripheral ciné arteriography.

Peripheral ciné arteriography.


Meconium Blockage syndrome.

Meconium Blockage syndrome.


A-mode ultrasound differentiation of soft-tissue masses.


Tumors of the sympathetic nervous system in children. An appraisal of treatment and results.


Radiotherapy in the conservative treatment of operable and locally inoperable carcinoma of the prostate.


Accumulation of chromosome damage under continuous low dose rate exposure.


Hyperbaric oxygen effect on experimental tumor growth.


Cinefluorographic study of prosthetic cardiac valves.


Subvalvular mitral insufficiency: roentgen aspects.


Unusual radiologic sign of loose mitral valve prosthesis.


In vivo behavior of artificial aortic and mitral valve prostheses: preliminary observations.


Quantitative microdensitometric x-ray analysis of vertebral trabecular bone. A preliminary report.


A new safety device for retrograde power femoral aortography.


Gastric ulcer and antral border.

Gastric ulcer and antral border.


Excision of cancer of the posterior pharyngeal wall with preservation of the normal larynx: a new surgical approach.


New techniques in the surgical treatment of Hirschsprung's disease.


Aneurysms of the branches of the abdominal aorta: diagnosis, management, and results.


Selective conservatism in hip fractures.


Anatomic location of the lower esophageal ring.


Benign tumors of the gallbladder.

Benign tumors of the gallbladder.


Pancreatic pseudocysts: delayed versus immediate treatment.


Massive hemorrhage from bronchial varices in mitral stenosis.


A simple technique for control of lumbar arteries during abdominal aortic aneurysmectomy.


Cyanoacrylate tissue adhesives in the treatment of recurrent spontaneous pneumothorax.


Further application of intestinal submucosa as a patch graft.


Intestinal anastomosis with n-butyl cyanoacrylate tissue adhesive.


The pancreatic secretory response to topical anesthetic block of the small bowel.


Aluminum prostheses as blood vessel replacements.


Nitrogen mustard hyperamylasemia and intestinal lesions.


The ventricular fibrillation threshold in respiratory acidosis and alkalosis.


A technique for the demonstration of ischemic areas of the heart at operation.


Atrophy of the arterial wall incident to localized chronic hypotension.


Assessment of the infant's response to stress.


Primary adenocarcinoma of the appendix.

Primary adenocarcinoma of the appendix.


The effect of induction of anaesthesia on peripheral haemodynamics.


The effects of clinical concentrations of halothane on the blood flow and oxygen uptake of the cerebral cortex.


Quality of epidural blockade. 3. Carbonated local anaesthetic solutions.


Effect of propranolol on arterial hypotension induced by halothane in the dog under nitrous oxide anaesthesia.


Clinical studies of induction agents. 18. A comparison of thiopentone and propanidid using multiple preference sequential analysis.


Comparative evaluation of the effects of some common premedications on the safety index of volatile anaesthetics in mice.


Accidental severe hypercapnia during anaesthesia. A case report and review of some physiological effects.


Epileptiform convulsions in children following premedication with Pamergan SP100.


Haemorrhage into the trachea and bronchi following induction of anaesthesia.


Homograft replacement of the aortic valve technique.


The duodenal spread of gastric carcinoma.


The association of gastric carcinoma with duodenal ulcer.


The role of venous obstruction in the formation of intra-abdominal adhesions: an experimental study.


Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face.


The change of bowel habits following vagotomy and pyloroplasty.


Membranous obstruction of the hepatic segment of the inferior vena cava.


The effect of prolonged withdrawal of endogenous stimuli to gastric secretion.


The latent period of baudet.

The latent period of baudet.


Impalement without serious injury.

Impalement without serious injury.


Iliac vein compression.--Its relation to iliofemoral thrombosis and the post-thrombotic syndrome.


Results of conservative management of internal haemorrhoids.


Leucocyte ascorbic acid levels in patients with malabsorption or previous gastric surgery.


Plasma cortisol levels in heart failure.


Promethazine poisoning: clinical and electroencephalographic observations.


Circadian rhythm of plasma 11-hydroxycorticosteroids in depressive illness, congestive heart failure, and Cushing's syndrome.


Medical investigation in cases of sudden death.


Today's drugs. Benzodiazepines.

Today's drugs. Benzodiazepines.


Driving and social drinking.

Driving and social drinking.


"Humps" in acute nephritis.

"Humps" in acute nephritis.


Familial concentration of ischaemic heart disease.


Propranolol-induced depression.

Propranolol-induced depression.


Metallic mercury poisoning.

Metallic mercury poisoning.


Drugs and thyroid-function tests.

Drugs and thyroid-function tests.


Cephaloridine and endocarditis.

Cephaloridine and endocarditis.


Side-effects of phenothiazines.

Side-effects of phenothiazines.


Ureteral ectopy in females.

Ureteral ectopy in females.


Ureterocele.

Ureterocele.


Interstitial cystitis: clinical considerations and treatment.


The clinical guise of retroperitoneal fibrosis.


The medical manpower shortage.

The medical manpower shortage.


Continuing education for what?

Continuing education for what?


The attitudes of physicians toward small-community practice.


The reactions of students in the oral examination.


Changes in the choice of medicine as a career among premedical students at the University of British Columbia.


A multiple-course curriculum.

A multiple-course curriculum.


The primary physician.

The primary physician.


A genetics program for undergraduate medical students at the University of British Columbia.


The vaginal irrigation smear: a positive method of cervical cancer control.


Determination of fetal maturity by spectrophotometric analysis of amniotic fluid.


Radiographic evidence of splenic torsion; report of a case.


Management of inversion of the uterus; report of 4 cases.


Primary malignant melanoma of the vagina.


Comparative evaluation of a hemagglutination inhibition test and a latex agglutination inhibition test for HCG.


Prelabor status evaluation. II. Weighted score.


Simultaneous triple malignant tumors of the female genital tract. Report of a case.


Middle cerebral artery occlusion in pregnancy. Review of the literature and report of a case.


A practical fetal-heart monitor.

A practical fetal-heart monitor.


Rheumatic cardiac disease and pregnancy: long follow-up of women with severe cardiac impairment.


Vesicoureteral reflux in pregnancy.

Vesicoureteral reflux in pregnancy.


Role of the state health department in family planning.


Proteinuria as a cause of false positive results in pregnancy tests.


The forgotten IUD as a cause of infertility. Review of world literature and report of a case.


Chemical and biological warfare in South Vietnam.


Biosynthesis of polyketides and related compounds.


Roles of the Bureau of the Budget.

Roles of the Bureau of the Budget.


Bioelectric phenomena related to protein-fixed charge in a crab nerve fiber. The bioelectrical characteristics of a crab nerve fiber subjected to solutions containing the impermeant anions ferrocyanide, glutamate, or ethanolsulfate substituted for chloride include prolonged slow depolarizations that elicit prolonged trains of impulses sulperimposed on the plateau portion. Propionate and nitrate depress repetitive firing while thiocyancite has only a slighit effect. Nerves treated with ferrocyanide lose potassium and gain sodium, which fact may account for their depolarization. On the other hand, studies with interference microscopy reveal shift by ferrocyanide in the interference fringe pattern of the sheath material; this suggests a reorientation of fixed charges in the protein layers by direct action of the anion on these layers. This may also account for the electrical manifestations observed.


Regeneration in crustacean motoneurons: evidence for axonal fusion. Crayfish motor axons remain excitable for over 100 days after severance from their central cell bodies, and continue to store and release normal amounts of transmitter substance. Evidence indicates that regeneration occurs by fusion of the central process with its surviving peripheral segment.


Apparatus for solid-phase peptide synthesis. The apparatus, designed for solid-phase peptide synthesis, consists of a round-bottom flask, rocked on a wrist-shaker, and fitted with a special dropping funnel and a fritted filter disc embedded within the flask. The dropping funnel is designed to wash down the polymer adhering to the neck of the flask. Solvents are removed through the fritted disc. Entire synthesis, and the removal of peptide from the polymer, are carried out without opening or removing the vessel from the shaker.


Creatine phosphokinase in thyroid: isoenzyme composition compared with other tissues. Considerable creatine phosphokinase activity was demonstrated in thyroid glands of several species. After starch gel electrophoresis, thyroid exhibited a creatine phosphokinase isoenzyme pattern different from that of muscle, heart, and brain. The isoenzyme repertory of various tissues and a hybrid enzyme produced from muscle and brain enzyme are consistent with the postulated dimeric structure of creatine phosphokinase.


Artifact produced in disc electrophoresis by ammonium persulfate. Ammonium persulfate, a common polymerizing agent for acrylamide gels, can inactivate yeast enolase and produce increased electrophoretic heterogeneity during disc electrophoresis in gels containing 8M urea. The use of riboflavin and light for polymerization or thioglycolate for removal of the persulfate are feasible alternatives.


Temperature tolerance of some Antarctic fishes. Three species of Antarctic fishes which live in constantly near-freezing waters have a markedly low upper-lethal temperature of 6 degrees C ; this is the lowest upper-lethal temperature reported for any organism. The fishes survive supercooling to -2.5 degrees C. Data on brain metabolism in vitro support the hypothesis that the central nervous system is a primary site of thermal injury.


Maternal and environmental influences on the adrenocortical response to stress in weanling rats. Handling rat pups either for 10 or 20 days after birth resulted in a reduction of adrenocortical steroids in the plasma at weaning after the pups were exposed to novel stimuli as compared with controls that were not handled. Nonhandled offspring of mothers which had been handled in infancy also show a reduction in plasma steroids in response to novel stimuli when compared to nonhandled weanling rats of nonhandled mothers. Handling of the offspring when they are infants appears to counteract the influence of the experience of the mother during her infancy.


Internal behavior in fish schools.

Internal behavior in fish schools. Structural changes within fish schools correlate with declines in environmental oxygen. The changes may result from the responses of individual fish to the environmental consequences of group metabolism. Individual behaviors are adaptive to the school in that they tend to maintain stability between school members and their environment.


Aucuba strain of tobacco mosaic virus: an unusual aggregate.


Genetics of mitochondria.

Genetics of mitochondria.


Combined craniotomy-rhinotomy for ethmoid cancer.


Effect of beta-hydroxybutyrate on lipid mobilization.


Osteogenesis imperfecta and otosclerosis: new investigations.


Fractures: check radiographs.

Fractures: check radiographs.


Summary of a Canadian study of smoking and health. The object of this study was to investigate the relationship between residence, occupation and smoking habits, and mortality from chronic diseases, particularly lung cancer. It was a prospective study, initiated by a questionnaire sent to Canadian veteran pension recipients. The study was based on the replies of 78,000 males and 14,000 females, together with data on the deaths occurring among these respondents over a six-year follow-up period-July 1, 1956 to January 30, 1962.The outstanding finding of this study was that cigarette smokers compared to non-smokers had excessive mortality, particularly from heart and circulatory diseases, lung cancer, and bronchitis and emphysema. The mortality ratios for heart and circulatory diseases were elevated even for those who smoked cigarettes less than five years, and remained relatively constant as the duration of smoking increased. The mortality ratios for lung cancer increased markedly as the duration of smoking increased. A small excess in mortality was noted among urban residents. An association between cause of death and occupation was not evident in this study.Findings based on the data on smoking collected in this study were incorporated into the Report of the U.S. Surgeon-General's Advisory Committee on Smoking and Health.


Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases.


Pulmonary fibrosis and hepatitis.

Pulmonary fibrosis and hepatitis.


Physical activity and cardiovascular health.


Children in the therapeutic community.

Children in the therapeutic community.


Tetanus treated with diazepam (valium).

Tetanus treated with diazepam (valium).


Multiple 3-methyleneoxindole reductases of peas, differential inhibition by synthetic auxins.


Reminiscences on the discovery and significance of some of the B vitamins.


Some nuclear factors in radiosensitivity.


Magnesium starvation of Aerobacter aerogenes. II. Rates of nucleic acid synthesis and methods for their measurement. The rates of synthesis of Aerobacter aerogenes nucleic acids were estimated during incubation of the bacteria in a Mg(++)-free medium. Deoxyribonucleic acid (DNA) synthesized during Mg(++) starvation, or in the preceding exponential growth, remained acid-precipitable for 2.5 hr before breaking down to acid-soluble products during a period of many hours. Rates of DNA synthesis were calculated by correcting the net amounts of DNA per milliliter to values that would have appeared had there been no decay. After the first few hours, this rate was constant, the amount of DNA present at the start of Mg(++) starvation being synthesized every 130 min. Rates of synthesis of total ribonucleic acid (RNA) were established in two ways: (i) by measurements of the incorporation of exogeneous uracil and glucose carbon into RNA, and (ii) by the accumulation of transfer RNA (tRNA), since this component is stable during Mg(++) starvation. After the first few hours, this rate was constant, the amount of RNA present at the start of Mg(++) starvation being synthesized about every 120 min. Fractionation by gradient centrifugation revealed that at all times of starvation the ratio of newly synthesized tRNA-rRNA was the same as it was during exponential growth. Furthermore, newly synthesized ribosomal RNA (rRNA) became a part of polysomal structures. Thus, in the absence of Mg(++), DNA, tRNA, and rRNA were synthesized in the same relative proportions as during exponential growth, at rates close to one-half the instantaneous rates of synthesis in the bacteria growing exponentially at the start of starvation.


Cell cloning experiments as models for radiotherapy: a critical appraisal.


Time-dose-fractionation relationships in radiation therapy.


Standardized peritonitis in the rabbit.

Standardized peritonitis in the rabbit.


Early ulcerative colitis in children and adolescents.


Electromyography in the management of the incompetent anal sphincter.


Evidence for cyclic fluctuations in radiosensitivity and their implications.


Preoperative radiation therapy in simulated cancer of the colon in rabbits.


Theoretical considerations on the influence of dose fractionation on effectiveness of radiation therapy.


Perforation of the colon--a hazard of colostomy irrigation: report of four cases.


Rectal prolapse in the mentally retarded.


Patterns of cell proliferation in gastrointestinal disease.


Colostomy perforation: report of four cases.


Analysis and determination of variables for optimum dose distribution in moving field therapy.


A model system for examining the action of anti-cancer agents at the cellular level in vivo.


Kinetics of cancer cell kill by chemotherapeutic agents in vivo.


Tracer analysis by computer simulation.

Tracer analysis by computer simulation.


Some mathematical and statistical methods in radiation therapy.


Preliminary observations and results with the use of hyperbaric oxygen and cobalt-60 teletherapy in the treatment of carcinoma of the cervix.


Cryoprecipitate--a new product for the control of bleeding in haemophilic patients.


Effect on fertility of continuous gamma-irradiation during the suckling period in mice.


Survival rates for uterine cancer of corpus and cervix treated in Denmark 1943-1952.


The pull-through operation.

The pull-through operation.


Light-induced susceptibility of Phaseolus vulgaris L. to tobacco mosaic virus infection. I. Effects of light intensity, temperature, and the length of the preinoculation dark period.


Changes in the ascorbate concentration of Pinto bean leaves accompanying the formation of TMV-induced local lesions.


A phage P22 gene controlling integration of prophage.


Biological and biochemical characterization of sowbane mosaic virus.


Lipids of the Rauscher mouse leukemia virus.


Infectivity neutralization--a serological method as applied to persistent viruses of beets.


A marked synergistic interaction of potato viruses X and Y in inoculated leaves of tobacco.


Ultrastructural and time-lapse studies on the replication cycle of the blue-green algal virus LPP-1.


A study of the self-assembly process in a small spherical virus. Formation of organized structures from protein subunits in vitro.


Studies on the inactivation of cell-fusing property of Newcastle disease virus by phospholipase A.


Alterations of plasma free fatty acids and glucose during labor.


Effect of estradiol-17-beta on oxytocin-induced contraction of the three separate layers of human pregnant myometrium.


Spontaneous premature rupture of the membranes. A prospective study.


pH values in the human fetus during labor.


Icterus and pregnancy.

Icterus and pregnancy.


Thrombophlebitis in pregnancy.

Thrombophlebitis in pregnancy.


Evaluation of fetal blood pH as a reflection of fetal well-being.


Fetal responses to maternal oxygen inhalation during hemorrhagic stress.


The relation between maternal and fetal oxygen tensions in sheep.


Ethnoracial comparisons of intraclass correlations and mean gestation times in spontaneous abortion and perinatal death. A report of the Collaborative Study of Cerebral Palsy.


Precedents of fetal death.

Precedents of fetal death.


Control of ovulation time and cycle length with clomiphene citrate.


Torsion of the uterine adnexa.

Torsion of the uterine adnexa.


Chromosomes of atypical (adenomatous) hyperplasia and carcinoma of the endometrium.


Patient acceptance of oral contraceptives. I. The American Indian.


The relationship between amniotic fluid pressure and uterine wall tension in pregnancy.


The variation of Reid index measurements within the major bronchial tree.


Airway obstruction due to hypoxemia in patients with chronic lung disease.


Pulmonary tularemia. A report of five cases and consideration of pathogenesis and terminology.


Etiologic studies of acute respiratory illness among children attending public schools.


Clinical examples of reinfection in coccidioidomycosis.


Isolation and identifiction of mycoplasma from the lower respiratory tract in bronchoscopy patients.


Biochemical study of ground substance in normal and emphysematous lungs.


Detection of circulating antibody in human cryptococcosis by means of a bentonite flocculation technique.


Use of latex particles in serology of tuberculosis.


N-acetylcysteine in cystic fibrosis. Mechanical and chemical factors in treatment by aerosol.


Chronic familial lung disease.

Chronic familial lung disease.


Group IV atypical mycobacterium infection occurring in association with mineral oil granuloma of lungs.


Tuberculous meningitis at Cleveland Metropolitan General Hospital 1959 to 1963.


The pulmonary function of hypogonadal men before and after testosterone.


Differential diagnosis of pulmonary alveolar infiltrates.


Calibration of a body plethysmograph for measurement of lung volume.


Flowpatterns in the peripheral circulation of the anesthetized dog.


Electron microscopic alterations in the central nervous system in experimental lymphogenic encephalopathy. I.


On the meaning of vesiculation in capillary endothelium.


Spiral guide wire for retrograde left ventricular catheterization.


The educational and political structure of ophthalmology in America.


Postoperative intestinal obstruction in children.


The surgeon and changing organizational structure of the teaching hospital.


Acute suppurative cholangitis. Experience with 15 consecutive cases.


Longitudinal pancreaticojejunostomy in alcoholic pancreatitis.


Portacaval shunt for portal hypertension.


Pulmonary lymphangitic metastases from breast carcinoma.


Bilateral carcinoma of the breast.

Bilateral carcinoma of the breast.


Disseminated melanoma. Biologic behavior and treatment.


Results of phrenicofacial nerve anastomosis for facial paralysis.


Familial hyperparathyroidism.

Familial hyperparathyroidism.


Thoracic emergencies. Indications for closed tube drainage and early open thoracotomy.


Bronchogenic carcinoma. Factors in survival.


Double primary tumors of the larynx and lung.


Open heart surgery without blood transfusion.


Temporary coronary artery occlusion using left heart bypass.


The surgical treatment of cavitary pulmonary coccidioidomycosis.


Determination of the blood-gas factor of the oxygen electrode using a new tonometer.


Leucopenic effects of prolonged nitrous oxide treatment.


The influence of drugs used in neuroleptanalgesia on cardiovascular and ventilatory function.


A comparison of aspirin and paracetamol.


Caudal analgesia: a simple and safe technique in paediatric surgery.


Tracheal stenosis following tracheostomy. A case report.


Dry displacement gas meters.

Dry displacement gas meters.


The effect of low molecular weight dextran and haemodilution on acid-base balance and lactate and pyruvate levels during cardiopulmonary bypass.


Sicklaemia retinopathy.

Sicklaemia retinopathy.


Lagophthalmos during sleep.

Lagophthalmos during sleep.


Conglomerate tuberculosis of the iris with scleral perforation.


Propranolol as ocular hypotensive agent.


Traumatic lesions of the optic chiasma.

Traumatic lesions of the optic chiasma.


Collateral blood flow after branch arteriolar occlusion in the human retina.


Early receptor potential in the human eye.


Episodic retinal ischaemia caused by reduced cerebral vascular resistance ("brain steal").


Conjunctival regressing Kaposi sarcoma.

Conjunctival regressing Kaposi sarcoma.


Ocular involvement in acquired toxoplasmosis.


Improved technique for padding eyes.

Improved technique for padding eyes.


Metabolism of amino acids in Agrobacterium tumefaciens. II. Uptake of L-valine by growing cells.


The lipids of Lipomyces lipofer.

The lipids of Lipomyces lipofer.


Membrane specificity of Leuconostoc mesenteroides for the stereoisomeric forms of glycine and valine dipeptides.


Complete hydrolysis of steroid conjugates and quantitative extraction of free steroids from urine.


Calendic acid in seed oils of the genus Calendula.


Heterogeneity of insulin. II. Chromatography of insulin on carboxymethyl cellulose in urea containing buffers.


A non-nucleotide polymer found in the DNA of the sand dollar, Echinarachnius parma. I. Isolaion.


Cytolytic action of corticosteroids on thymus and lymphoma cells in vitro.


Phosphonolipids. 8. Synthesis of phosphonic acid analogues of diether L-alpha-lecithins.


A non-nucleotide polymer found in the DNA of the sand dollar, Echinarachnius parma. II. Preliminary characterization.


Synthesis of L-alpha-phosphatidyl-(alpha-methyl)cholines.


Regulation of the initiation of hemoglobin synthesis in mation induced by exogenous delta-aminolevulinic acid.


Acid-soluble metabolites of 2,6-diaminopurine in L strain mouse cells.


Hemoglobin G Saskatoon: beta-22Glu--Ala.


The growing demand for technical assistance in feeding the worker.


International facets of USDA nutrition research.


Nutritive value of the diets of medically indigent pregnant women.


Factors affecting the rate of cooling of cornstarch-thickened mixtures.


Influence of time and temperature on ascorbic acid stability.


Ascorbic acid and color of vegetables.

Ascorbic acid and color of vegetables.


Regional distribution of pulmonary ventilation and perfusion in obesity. Five women and three men, all obese and weighing 95 to 140 kg, were studied by routine pulmonary function tests and by a radioactive xenon technique, while seated upright at rest, to measure the regional ventilation and perfusion distribution in the lung. In four subjects in whom the expiratory reserve volume averaged 49% of predicted normal, the ventilation distribution as measured with (133)xenon was normal. In the remaining four subjects, in whom the expiratory reserve volume was reduced to less than 0.4 L and averaged only 21% of predicted values, the distribution of a normal tidal breath was predominantly to the upper zones. In all subjects the perfusion distribution was predominantly to the lower lung zones but was slightly more uniform than in normal nonobese subjects. During tidal-volume breathing, therefore, in four subjects the ventilation and perfusion distribution was substantially normal, whereas in the remaining four perfusion was maximal in the lower zones, to which ventilation was significantly reduced. These findings show that there may be significant ventilation/perfusion abnormality on a regional basis in obese subjects, this abnormality bearing a close relationship to the reduction in expiratory reserve volume, a finding predictable from recently published data on normal nonobese subjects (1). The abnormalities of ventilation/perfusion relationships that were demonstrated in four of the eight obese subjects could cause a reduction in arterial oxygen tension during resting tidal ventilation.


The effect of arterial reconstruction in severe ischemia of the foot.


Studies on the renal excretion of norepinephrine. Studies were carried out in anesthetized dogs to investigate the renal clearance of norepinephrine (NE) and to determine the origin of this amine in the urine. Infused radioactive NE was cleared from plasma at a rate averaging 63.8% of the glomerular filtration rate. NE was shown to be freely filterable, and evidence has been presented which suggests but does not prove that the amine is partially reabsorbed from the glomerular filtrate; metabolism of NE in the tubular fluid by catechol-o-methyl transferase has not been excluded. The clearance of this catecholamine was not affected by changes in urine pH or flow. Total chronic denervation of one kidney was shown to have no effect on the rate of excretion of endogenous NE. Therefore, the NE that is excreted in the urine would appear to be solely derived from the catecholamines in circulating blood.


Ammonia movement in the small intestine: preferential transport by the ileum. Isolated, surviving sacs of everted small intestine were used to characterize ammonia transport in the golden hamster. Jejunal and ileal sacs incubated aerobically in ammonia-free test solution liberated the same quantity of ammonia as did sacs that were filled and immediately emptied of their contents, indicating no significant evolution of metabolic ammonia. Under aerobic conditions, ileal sacs transferred a solution of high ammonia content from the mucosal surface to the serosal surface against a concentration gradient. This transport was not glucose dependent and exhibited first-order Michaelis-Menten kinetics. Inhibition of absorption occurred with anaerobiosis, 2,4-dinitrophenol, and sodium cyanide. In jejunal segments ammonia was not transported against an adverse chemical gradient. Ileal ammonia absorption was accompanied by bicarbonate secretion and acidification of the serosal solution. Both bicarbonate movement and pH gradients were abolished by inhibitors of ammonia transport. In the jejunum, the absence of ammonia movement occurred in association with minimal bicarbonate secretion and no appreciable change in serosal pH. Despite the creation of hydrogen ion gradients tending to augment or to retard ammonia absorption by nonionic diffusion, ammonia movement was unaffected, i.e., relative acidification of serosal contents did not augment ammonia absorption, and relative alkalinization of serosal fluid caused no inhibition of ammonia transport. In the absence of bicarbonate ion, ammonia transport did not occur. The significance of these findings is discussed with consideration of both ionic and nonionic mechanisms of ammonia movement. It is suggested that ammonia is absorbed in the ileum by active ionic transport.


Metabolism of circulating disaccharides in man and the rat. The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7+/-1.89 g of the lactose and 6.3+/-1.39 g of the sucrose was excreted in the 24-hour urine sample. Only 0.11+/-0.03 g of the infused maltose was recovered in the urine, suggesting that the maltose was metabolized.After injection of (14)C-labeled lactose and sucrose in rats, 6.2+/-2.7 and 7.6+/-2.4%, respectively, was oxidized to (14)CO(2) in 24 hours; 62.1+/-13.5 and 68.4+/-10.8% of the respective disaccharides was excreted into the urine. Conversely, after injection of (14)C-labeled maltose 54.6+/-7.0% was oxidized to (14)CO(2) and 4.8+/-3.9% excreted in the urine. The per cent of maltose oxidized to CO(2) was similar to that of glucose. In addition to small intestinal mucosa, homogenates of rat kidney, brain, and liver as well as serum were found to have measurable maltase activities. The role of these tissue maltases in the metabolism of circulating maltose and maltosyloligosaccharides is discussed.


Renal metabolism of alanine.

Renal metabolism of alanine. In the acidotic dog, alanine is extracted from plasma and utilized as a precursor of ammonia. Simultaneously, it is formed de novo within tubular cells and added to renal venous blood. When plasma concentration is within a normal range, production of alanine greatly exceeds utilization. Increasing the plasma concentration reduces production and increases utilization of plasma alanine. The infusion of glutamine increases the renal production of alanine without appreciable change in utilization of plasma alanine. These results are consonant with the view that alanine is metabolized by transamination with alpha-ketoglutarate to form glutamate, which is subsequently deaminated oxidatively to liberate ammonia. Conversely, alanine is formed by transamination of pyruvate with either glutamate or glutamine and is added to renal venous blood. The balance between production and utilization is dependent, at least in part, on the concentrations of the reactants.


Phenoxybenzamine (dibenzyline) and renal blood flow during extracorporeal circulation.


Simplified pulmonary embolectomy.

Simplified pulmonary embolectomy.


Sclerotherapy of varicose veins with an improved "air-block" technique.


The influence of partial CO2 tension on arterio-venous oxygen difference in deep hypothermia.


Role of the sympathetic nervous system in regulating renin and aldosterone production in man. Several lines of evidence have been developed indicating that the sympathetic nervous system may play a role in mediating the renal and adrenocortical secretory responses to upright posture and sodium deprivation. Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold. Aldosterone excretion was also increased by catecholamine infusion. In normal subjects the stimuli of upright posture and of sodium depletion both resulted in increases in urinary catecholamines, plasma renin activity, and urinary aldosterone. A patient with severe autonomic insufficiency did not experience normal elevations of urinary catecholamines, plasma renin activity, or urinary aldosterone in response to upright posture or sodium deprivation, despite a substantial fall in arterial blood pressure. When orthostatic hypotension was prevented by infusion of catecholamines, however, increases in plasma renin activity and in aldosterone excretion were observed. We suggest that both upright posture and sodium depletion lead to decreases in effective plasma volume and increases in sympathetic nervous system activity. This increase in sympathetic activity is then responsible for an increase in renal afferent arteriolar constriction, leading to an increase in renin secretion and, ultimately, an increase in aldosterone secretion.