The mode of action of taraxein and LSD.

The mode of action of taraxein and LSD.


Cogito, ergo sum: discussion of perception, mind and brain.


The use of glucagon in terminating insulin coma.


Effect of meprobamate on patients in intensive psychotherapy.


A clinical study of Marsilid in psychotic depressed patients.


Effects of para-hydroxypropiophenone on the secretion of hypophyseal hormones in frog larvae.


6-Ketoprogesterone and its biological actions.


Sex reversal in female tadpoles induced by the treatment with methylmercaptoimidazole.


Comparative studies on the activity of glutamic dehydrogenase and glutamic-oxalacetic transaminase of rat and dog tissues with special reference to thyroid physiology.


Effect of mesoxalate on insulin content of pancreas.


Experimental studies on the hypothalamic control of the female gonadal function. I. Ovulation induced by electrical stimulation of the hypothalamus in rabbits.


Glucose tolerance in rabbits following repeated small doses of alloxan.


Studies on the salivary gland hormones labeled with I 131. 3. Effect of ligation of several blood vessels on the degradation and distribution of I 131-labeled parotin in vivo.


Studies on the salivary gland hormones labeled with I 131. 4. Studies on the degradation of I 131 labeled parotin by several tissue homogenates of rat.


On the proliferation stimulating nature of the regenerating nerve fibers.


The effect of local testosterone administration on the prostate of the rat.


Plasma 17-hydroxycorticosteroid response to hypothalamic stimulation in the conscious rhesus monkey.


A study of adrenal radioactivity subsequent to parenteral Co60 labeled vitamin B12.


Dissociation of adrenal ascorbic acid and corticosterone responses to stress in rats with hypothalamic lesions.


On the induction of molt in birds by 17 alpha-oxyprogesterone-17-capronate.


Some effects of sex hormones and homologous gonadotrophins on the early development of the rudimentary gonad in fowl.


The pathogenesis of adrenal regeneration hypertension.


The reaction of several protein hormones with periodate.


Biological actions of 17 alpha-(2-methallyl)-19-nortes-tosterone, an orally active progestational agent.


Mechanism of antithyroid effects of a sulfonylurea in the rat.


Effects of feeding thiouracil and/or thyroid powder upon pubic symphyseal separation in female mice.


Immunological investigations on bovine pituitary growth hormone.


The effects of estrone on the response to testosterone propionate in castrated male rats.


Failure of suramin (Bayer 205; germanin) to cause changes in the adrenal cortex of the rat.


Some factors effecting spermatokinesis in the testes of the house sparrow (Passer domesticus).


Assay of lactogenic hormone.

Assay of lactogenic hormone.


Adverse effects of crowding on lactation and reproduction of mice and two generations of their progeny.


Pituitary lactogenic in lactating rats.

Pituitary lactogenic in lactating rats.


Hormonally-induced lactation in hypophysectomized rats.


The effects of several steroids on fecundity in female rats.


The localization of I 131-labeled triiodothyronine and thyroxine in the pituitary and brain of the male guinea pig.


The effects of several steroids on mating behavior, ovulation and pregnancy in female rats.


The partition and binding of calcium in the serum of the laying hen and of the estrogenized rooster.


The enhancement of relaxin-induced growth of the pubic ligament in mice.


Blockade of ovulation in the rat by mesencephalic lesions.


The peripheral action of tolbutamide in domestic fowl.


Capacitation of rabbit spermatozoa in the uterus with special references to the reproductive phases of the female.


Paper electrophoretic studies on pituitary extracts from normal and thyroidectomized rats.


Pituitary function in the thyroidectomized rat.


Effects of growth hormone on glucose utilization in fasted rats.


Ascorbic acid deficiency and adrenocortical function in the guinea pig.


The influence of estradiol and cortisol on uterine histamine of the ovariectomized rat.


The stability of natural and synthetic neurohypophysial hormones in vitro.


The antidiuretic potency of arginine and lysine vasopressins in the pig with observations on porcine renal function.


Differences in the antidiuretic responses of rats to the intravenous administration of lysine and arginine vasopressins.


Nature of radioiodine not dischargeable with perchlorate in the thyroid glands of thiouracil-treated rats.


Insulin in blood.

Insulin in blood.


Studies on the mechanism of action of carbutamide.


The action of sulphonylureas and insulin on the glucose output from the liver of normal dogs.


In memorium: Professor M. Damodaran.

In memorium: Professor M. Damodaran.


Congenital afibrinogenemia.

Congenital afibrinogenemia.


Lung weight and oxygen tension in newborn rats.


Anaemia in foetal lambs.

Anaemia in foetal lambs.


Crystalline acetates from croton resin.

Crystalline acetates from croton resin.


The structure of Schmidt's aluminium hydroxide gel.


A new evidence for induction of respiration deficiency in yeast by acriflavine.


A study of the temperature dependence of radiation sensitivity of dry spores of Bacillus megaterium between 5 degrees K and 309 degrees K.


The effect of glycerol on the biosynthesis of benzylpenicillin by the washed cells of Penicillium chrysogenum.


A colorimetric determination of aminooxy acids.


Reversibility of a facilitatory action of reserpine on the central nervous system, by methylamphetamine.


Influence of hormones and x-rays upon the tissue mast cell.


Parodoxical effect of quinidine upon coronary flow of the isolated heart at different temperatures.


An hypothesis to explain the relation between the synthesis and release of animal viruses from infected cells and the lipid content of the viruses.


Paper electrophoresis of soluble proteins from regenerating rat liver.


Comparison of the structure, as revealed with the electron microscope, and the physiology of the unmedullated fibers in the skin nerves and in the olfactory nerves.


X-ray diffraction studies on the myelin sheath in peripheral and central nerve fibres.


Studies of the chemical composition of the nervous system.


Axon-satellite cell relationships in peripheral nerve fibers.


The role of thiamine (vitamin B1) in nervous excitation.


Histochemical demonstration of phosphatases in the central nervous system of the rat.


Experiments on current flow and ionic movements in single myelinated nerve fibers.


An attempt to determine the origin of synaptic vesicles.


The fine structure of electric tissue.

The fine structure of electric tissue.


The productive capacity of the neuron in retrograde reaction.


Transport processes in membranes in relation to the nerve mechanism.


On undifferentiated neuronal spread of excitation.


The approach to unitary analysis of neuron response.


Component analysis of action potentials from single neurons.


Excitation, inhibition and coordination of cortical neurones.


The morphology of synapses in the central nervous system.


Parameters of integrative action of the nervous system at the neuronal level.


Morphological and cytochemical observations on the post-synaptic membrane at motor end-plates and ganglionic synapses.


Submicroscopic morphology and function of the synapse.


Synapses in the superior cervical ganglion and their changes under experimental conditions.


Study of adrenergic cerebral neurohumors in relation to synaptic transmission mechanisms.


Photochemical aspects of visual excitation.


Subthreshold excitatory processes in the eye of Limulus.


Electrophysiological analysis of the visual systems in insects.


Electrical studies of color vision in the turtle.


The slow electrical response of the olfactory end organs.


The ultrastructural organization of the organ of Corti and of the vestibular sensory epithelia.


Synaptic inhibitory mechanisms: properties of dentrites and problems of excitation in isolated sensory nerve cells.


Studies in the nervous mechanism of taste.


An analysis of the changes attending fertilization of the sea urchin egg.


Studies on membrane resting potentials of muscle: effects of K-lack, x-irradiation and DNP.


The morphology of muscle fibers and muscle cells with different properties of conduction of excitation.


Quantitative and cytochemical studies on the intestinal plexuses of the guinea pig.


Ciliary coordination in the protozoa.

Ciliary coordination in the protozoa.


Fine structure of the light receptors in the compound eyes of insects.


New investigations on cardiac nerves; an electron microscopic study.


Clinical and experimental notes on the etiology of psoriasis.


The mechanism of pain in angina pectoris; an electron microscopic clue.


Time relations of the precordial force-thrust and the acceleration ballistocardiogram from a pendulum and ball bearing platform.


Preliminary observations on the relation of the precordial forcethrust to intracardiac pressure events.


Inhibition of tween shock in dogs by flavonoids.


Experimental data to the changes in phosphorus metabolism in uremia.


The urinary excretion of estrogens in men affected with neoplasia of the respiratory or digestive system. I. Bronchogenic carcinoma.


The urinary excretion of estrogens in men affected with neoplasia of the respiratory or digestive system. II. Neoplasia of the digestive system.


Effect of stress on lower neuron activity.


Design and fabrication of prosthetic valves.


Pigeon crop weight responses to single local intradermal injections of prolactin.


The Abderhalden reaction; a review of the literature on the defense proteinases (Abwebrfermente).


Further observations on blood factor U, with special reference to the blocking test.


Surgical closure of perforated tympanic membrane by skin grafting.


The turbinate bodies.

The turbinate bodies.


Alterations in refraction and their clinical significance.


Congenital anomalies of the thyroglossal tract.


TYMPANOPLASTY and other procedures for closing ear drum perforations.


Landmarks in the mastoid x-ray film.

Landmarks in the mastoid x-ray film.


Reflux esophagitis.

Reflux esophagitis.


Pitfalls in rhinoplastic operations; prevention.


Fixation disparity.

Fixation disparity.


Central retinal vein thrombosis in angle closure glaucoma.


Fibrous dysplasia of the skull and temporal bone.


Papillary cystadenoma of the sinuses.

Papillary cystadenoma of the sinuses.


Cystic hygroma of the submaxillary region.


Diagram for the treatment of comitant horizontal deviations.


Meniere's syndrome versus Meniere's disease.


Acoustic neuroma.

Acoustic neuroma.


Remarks at the annual federation banquet on introducing Dr. Walter Bierring.


Government and the medical school.

Government and the medical school.


Beriberi.

Beriberi.


Endemic goiter.

Endemic goiter.


Research and training in nutrition.

Research and training in nutrition.


Hypovitaminosis A.

Hypovitaminosis A.


[Viktor Schilling on his 75th birthday].


The origin of the pre-albumin in the cerebrospinal-fluid.


The frenum praeputii and the defloration of the human male.


Psychotherapy in the psychiatric hospital; with special reference to double treatment.


Considerations on mental disorders in some diseases of the eye.


On the notion mutuality.

On the notion mutuality.


A short preliminary note on some presuppositions of the Columbus-test for children.


Notes on the Icarus syndrome.

Notes on the Icarus syndrome.


Reactions of therapists to patients in psycho-analysis.


Problems with regard to the aetiology and genesis of psychic diseases.


Multiple equilibria.

Multiple equilibria.


Science and mental health.

Science and mental health.


On the concept of mental health.

On the concept of mental health.


Problems of schizophrenia; the metabolic and physiological survey of a case of periodic catatonia from illness to recovery.


Epilepsy starting in adult life, with rapid mental deterioration.


Problems with regard to the aetiology and genesis of mental diseases. II.


Trigeminal neuralgia and arteriovenous aneurysma of the posterior fossa.


The C.S.F. aspects in leucoencephalitis.


Some considerations on Huntington's chorea, in connection with a case, treated with procaïne-amide.


[Guillain-Barré syndrome].

[Guillain-Barré syndrome].


Radioisotopes and the general physician.


Hiatal hernia.

Hiatal hernia.


The bacteriologic examination of urine.

The bacteriologic examination of urine.


The social component of clinical medicine.


Neurologic study in cases of stupor and coma.


The uterine cervix.

The uterine cervix.


Current attitudes about atherosclerosis.


The doctor's role in disability evaluation.


A technique for better x-ray visualization of the clavicle.


Histoplasmosis.

Histoplasmosis.


Studies on cretinism.

Studies on cretinism.


The sign of the patent bronchus.

The sign of the patent bronchus.


The generalist looks at constipation.

The generalist looks at constipation.


Interviewing with narcosis.

Interviewing with narcosis.


The treatment of parkinsonism.

The treatment of parkinsonism.


More social security benefits?

More social security benefits?


Planning your tax program. I.

Planning your tax program. I.


Planning your tax program.

Planning your tax program.


The Achilles heel of health insurance.

The Achilles heel of health insurance.


A practical approach to pigmented nevi and related lesions.


The laboratory diagnosis of respiratory viral disease.


Respiratory viral diseases.

Respiratory viral diseases.


The role of the physician in the management of periodontal disease.


The care of the patient.

The care of the patient.


The treatment of leukemia.

The treatment of leukemia.


The importance of allergy studies in allergic eczema (atopic dermatitis).


A RARE common disease and a common rare disease: brucellosis and leptospirosis.


Traumatic saccular aneurysm of the thoracic aorta.


The management of the cardiac arrhythmias.


More on skin diving.

More on skin diving.


Major medical insurance.

Major medical insurance.


How to improve business management and human relations.


Improving your human relationships.

Improving your human relationships.


The doctor, the nurse and narcotic addiction.


PEDIATRIC aspects of medical practice.

PEDIATRIC aspects of medical practice.


The incidence of peptic ulcer among patients on long term prednisone therapy.


Serum glutamic-oxalacetic transaminase in acute pancreatitis.


Transfer of neutral red into the stomach.


Gastric secretory studies during prolonged salicylate administration in a comatose man.


Familial DubinJohnson syndrome.

Familial DubinJohnson syndrome.


An evaluation of the isotopic iodotriolein method; its correlation with vitamin A absorption.


Gastric diverticula, with special reference to subjective manifestations.


The folic acid excretion test in the steatorrhea syndrome.


Remarks on the clinical and radiologic diagnosis of Meckel's diverticulum; report of a case.


The effect of an ordinary and of an excessively fatty breakfast on human gastric antral motility.


Influence of amino acid therapy in chronic idiopathic pruritus ani.


Regional ileitis with onset in patients over fifty years of age.


[Choleresis & choleretics; clinical trial of 1314 CB].


Some relationships between fantasy and self-report behavior.


Interaction between authoritarian and nonauthoritarian principals and teachers.


[Prenatal care & perinatal mortality].

[Prenatal care & perinatal mortality].


Some factors related to the choice-status of ninety eighth-grade children in a school society.


Use of presacral oxygen insufflation in renal tumors and cysts undiagnosed by routine procedures.


The conservative attack upon problems of aging.


Diagnosis and management of pleural effusion.


The value of electroencephalographic examinations in psychiatric disorders of old age.


Adenomatous polyps of the colon and rectum.


Serum proteins in aged people; electrophoretic separation of proteins.


Fractured hips in psychotic patients.

Fractured hips in psychotic patients.


Psychiatric screening in a home for the aged. I. A follow-up study.


The rural aged.

The rural aged.


Clinicopathologic conference: Bronx Veterans Administration Hospital.


[Pulmonary resection in tuberculosis of children in relation to the tracheobronchial lymph nodes; surgical aspects].


The relationship between airborne bacteria and organisms recovered from children in a burns unit.


Sepsis in burns.

Sepsis in burns.


Observations and experiences in experimental extracorporeal circulation.


The embryology of cor triloculare biatriatum with bulbar (rudimentary) cavity.


JOHN HENRY RYFFEL.

JOHN HENRY RYFFEL.


Hector Charles Cameron.

Hector Charles Cameron.


The effects of cortisone, ACTH, nitrogen mustard and colchicine on the cell population of degenerating spinal tracts in the rabbit.


Conjoined twins as an obstetric problem.


Sydenham's chorea.

Sydenham's chorea.


Cerebral complications following experimental extracorporeal circulation.


A survey of the results of treatment of intracranial tumours in recent years.


The reliability of observations at cardiac catheterization.


Alcoholic cardiomyopathy in a man with Gaustad's syndrome.


Investigation of quercus glandium spiritus.


Introductory lecture on homeopathy to students at Hahnemann.


A case of agammaglobulinemia.

A case of agammaglobulinemia.


Virus diseases as problems in medical practice.


Sporotrichosis.

Sporotrichosis.


Diagnostic radiation and its significance to man.


Hypogammaglobulinemia (agammaglobulinemia) in a ten-year-old girl.


Leiomyosarcoma of the duodenum.

Leiomyosarcoma of the duodenum.


[Data on Trypanosoma rangeli Tejera, 1920. II. Experimental injection of the culture into Didelphis marsupialis & Didelphis paraguayensis paraguayensis (opossums)].


The hard facts: hospital financial operations.


Excess utilization of Blue Cross by hospital personnel.


Do you diagnose your hospital management needs?


Viewing the Blue Cross.

Viewing the Blue Cross.


What do current Blue Cross troubles mean to industry?


The role of administration in hospital financial management.


The missing woof which puts the warp into third-party reimbursement plans.


Small hospital's clinic; a hospital employee's charity fund.


Snow storm creates special problems for x-ray department; hospitals adjust to emergency.


Commercial baby formulas are safer and cheaper.


Practical automation at the Stamford Hospital. II.


Static electricity and corrective measures in operating rooms. II.


Work organization and simplification. II.


An intensive nursing care unit.

An intensive nursing care unit.


Citrus fruits mean more than orange juice at breakfast.


Drug samples.

Drug samples.


Practical application of standards and specifications.


Linen supply.

Linen supply.


May Day means preparedness; disaster forum.


The truth about x-rays. II.

The truth about x-rays. II.


Effective use of lay executives in Catholic hospitals.


Whither goeth charities?

Whither goeth charities?


The nurse-anesthetist and the law.

The nurse-anesthetist and the law.


Medical and social changes in a changing era.


Legislative roundup.

Legislative roundup.


Patron saints of Catholic hospitals.

Patron saints of Catholic hospitals.


An adminstrator looks at nursing service.


Sodality project implements classroom theory.


Miracle in Leadville.

Miracle in Leadville.


Essentials of laboratory administration.


Psychiatric O. P. Center serves Hoboken area.


Good dietitianpatient relations.

Good dietitianpatient relations.


Hospital sisters in the personnel apostolate.


Public relations; office staffs learn hospital secrets.


The area hospital council coordinates disaster planning.


Gown hangers in nursery conserve floor space.


Seton Hall program upgrades New Jersey medicine.


The importance of cleanliness in hospitals.


An administrator looks at nursing service.


A juniorate program for nursing sisters.


Three malpractice decisions.

Three malpractice decisions.


Rx for moving mountains.

Rx for moving mountains.


The role of religious in the business office.


A lay executive examines lay executives in Catholic hospitals.


Is there time to change public opinion?

Is there time to change public opinion?


New materials, new processes mean new products.


The volunteer in the hospital library.

The volunteer in the hospital library.


The exciting challenge of radioactive isotopes.


Good dietitian-patient relations.

Good dietitian-patient relations.


Purchase & inventory control of pharmaceuticals.


Centralized decentralized housekeeping.

Centralized decentralized housekeeping.


Technology and spiritual values.

Technology and spiritual values.


Disaster drill serves four-fold purpose.


A challenge to the apostolate of care.

A challenge to the apostolate of care.


How new rules affect medicare payments.

How new rules affect medicare payments.


The nurse-anesthetist and the law. II.

The nurse-anesthetist and the law. II.


Nursing service: an integral department or merely a figurehead?


Should ob-gyn be separated?

Should ob-gyn be separated?


Must local superiors also administer hospitals?


25 Years of O.P. service: a retrospect.

25 Years of O.P. service: a retrospect.


Patron saints of Catholic hospitals.

Patron saints of Catholic hospitals.


Roentgenographic positioning aids.

Roentgenographic positioning aids.


Teaching religion in professional schools of nursing.


The meaning of experience.

The meaning of experience.


For safety's sake.

For safety's sake.


Caution, danger, death.

Caution, danger, death.


Responsibilities deepen for technologists.


The philosophy of group purchasing.

The philosophy of group purchasing.


Listening: the lost art in communications.


Canada's national hospital insurance program; what it is.


How to handle four kinds of hospital interviews.


Canada's national hospital insurance program; how the program is implemented.


Canada's national hospital insurance program; how the program developed.


What's ahead for the hospital accountant.


Forces affecting the community's hospital bill. II.


Canada's national hospital insurance program; how the program affects hospitals.


16 Safeguards against medication errors.


Recommended safe practice for hospital operating rooms.


Spot check system offers continuous stores control.


9 Special dietary services that build good will.


Volunteers pitch in in this disaster program.


What hospitals can do about the underfinancing of hospital service.


A history of the hospital bed.

A history of the hospital bed.


The almshouse: chronic disease hospital of the future?


How to get the most from old guard employees.


The influence of prepaid physician's service on hospital utilization.


The newly graduated nurse.

The newly graduated nurse.


How products of the future will affect purchasing.


What's right with diploma schools of nursing; a reaffirmation of belief.


68 Ways to cut heating costs.

68 Ways to cut heating costs.


Short-stay and long-stay: study of two recovery rooms offers clues to intensive care unit design.


8-Hour high school day dramatizes theme of National Hospital Week.


8-Month apprentice program is basis of long-range recruitment drive.


Combination charge and chart form speeds up and simplifies this charge system.


New kinds of service and facilities for contemporary convalescent care.


Ordered definitions.

Ordered definitions.


Architecture for the aged; factors to consider in designing facilities for elderly patients.


Nutritional value of patient selected versus nonselected menus.


How the pharmacist can help solve problems in purchasing medical supplies.


Growing use of radioisotopes demands clear-cut procedures for handling and processing radiation contaminated linen.


Awareness; key to safety.

Awareness; key to safety.


How to train nursing aides and orderlies.


Staff fights staph.

Staff fights staph.


For patients only.

For patients only.


Why it's practical to hire the handicapped.


Weekly on-the-spot inspections.

Weekly on-the-spot inspections.


Handbooks and handshakes help Syracuse hospitals strengthen press relations.


Putting value analysis to work for hospitals.


Employee health service.

Employee health service.


Portion control ends waste of cleaning supplies.


The estimation of dry skeletal weight by photometry of roentgenograms.


Some Monte Carlo methods applied to an epidemic of acute respiratory disease.


Variations within individuals in human biology.


Changing trends in the Chinese-American population.


Contribution to the study of the question of association between two diseases.


A new microfilaria in the dog.

A new microfilaria in the dog.


Notes on the seasonal variations in the density of Culex fatigans and filarial infections in them, in Mangalore Town, Madras State.


Note on the quantitative estimation of the degree of D.D.T. resistance in A. subpictus grassi, 1899 in Delhi State.


Urban, semi-urban and rural filariasis in Ballia District, Uttar Pradesh.


Advances in the study of Culicine mosquitoes of Hainan, South China.


Filariasis survey in the Laccadive, Minicoy and Amindivi Islands; Madras State.


The behaviour of A. sundaicus Rodenwaldt in relation to the application of residual insecticides in Tjilatjap, Indonesia.


A growth factor in extract of Escherichia coli replacing streptomycin in streptomycin dependent E. coli.


Salmonella serotypes in India.

Salmonella serotypes in India.


The role of adrenal cortex in the genesis of congenital abnormalities. I. Teratogenic and anti-teratogenic action of cortisone acetate: a preliminary report.


Fatty acids from the lipids of streptomycin resistant tubercle bacilli.


Effect of acute systemic stress upon serum and urinary inorganic phosphorus in normal and parathyroidectomized rats.


Mechanism of cholinergic potentiation of morphine analgesia.


Protein metabolism in scorbutic monkeys.


Determination of the surface area of the body of Indian females.


Mechanism of dual action of local hormones (adrenaline, acetylcholine and histamine) on involuntary musculature of the body.


Study of the preventive action of the anti-fatty liver fractions of pancreas on fatty livers induced by ethionine. II. Effect of intragastric administration.


Observations on the binding of vitamin B12 by rat serum protein fractions.


Proliferation of chick embryonic heart fibroblast in various media.


Urinary amino-acid excretory patterns of patients undergoing electro-convulsive therapy (E.C.T.).


Glucose tolerance of mental patients undergoing electro-convulsive therapy (E.C.T.).


Studies on pyridine nucleotide metabolism. II. The effect of protein and choline deficiency on some DPN requiring oxidative enzymes in liver.


Studies on pyridine nucleotide metabolism. I. The effect of protein and choline deficiencies on the breakdown and synthesis of DPN in the rat liver.


Some observations on the causative relationship between the thiamine, riboflavin and nicotinic acid deficiency and occurrence of toxaemias of pregnancy.


An experimental study of anthelmintic action of oxygen against Ascaris lumbricoides, by exposure to different concentrations of oxygen for variable lengths of time.


Observations on adreno-cortical response in orthopedic surgical procedures.


The vaginal smear in menopause.

The vaginal smear in menopause.


The effect of cortisone on tumor growth and metastasis.


Angioblastic meningiomas; report of four cases.


Modern practice in immunization. 15. Rabies immunization.


Disorder of the nervous system in carcinoma (carcinomatous neuropathy and myopathy).


Symptomatic relief treatment of the stuffy nose.


The vitamins. 5. Pyridoxine (vitamin B6).


New antiamebic drugs in the treatment of patients with E. histolytica trophozoites in the stools.


On pediatric education in the USSR.

On pediatric education in the USSR.


Serum protein fractions in malnutrition in children.


Effect on the foetus of prolonged pregnancy.


A review of post-polio paralysis in children.


Paediatric nursing curriculum.

Paediatric nursing curriculum.


Protein malnutrition.

Protein malnutrition.


The occurrence of an additional phalanx in the thumb.


Care of the feet in children.

Care of the feet in children.


The role of melanophore hormone of the pituitary in the colour changes of cold and warm blooded animals; a review.


Adrenogenital syndrome in a boy of four years.


Management of neo-natal anoxia, with reference to intragastric oxygen administration.


Osmotic fragility of erythrocytes in non-haemolytic anaemias in infancy and early childhood.


Perinatal anoxia.

Perinatal anoxia.


Plasma insulin estimation and its significance in diabetes mellitus.


Anthelmintic screening of substituted bis-benzothiazoles.


Acetylcholine and adrenaline-noradrenaline sensitivity in denervated parotid gland of monkey.


Some more observations on influence of cooking on the nutritional values of foods; cobalt content of some cooked foods.


Pharmacological studies on Melia azadirachta [N. O. Meliaceae]. II. Estrogenic and antipyretic activity of neem oil & its fractions.


Epidemiological aspects of acute respiratory diseases including influenza.


Electromyography as a method of investigation of the functional status of the neuromuscular apparatus.


Shift work and health.

Shift work and health.


Pandora's box: new viruses and respiratory tract disease.


The control of acute respiratory disease in industry; with special reference to influenza.


Vocational rehabilitation and selective placement of disabled workers.


Uses of oxygen in industrial medicine.

Uses of oxygen in industrial medicine.


Clinical approach and laboratory aids in diagnosis and treatment of radiation injury.


A proposed technique for assessing adjustment at work.


Developments and recent trends in industrial medicine in Poland.


Tetanus as a concomitant of work accidents in tropical countries.


Comparative study of dermatological ointments: effectiveness of tarsteroid-neomycin compared with hydrocortisone alone.


Basal cell epithelioma following a single trauma.


Labor's viewpoint of alcoholism in industry.


Current concepts in geriatrics.

Current concepts in geriatrics.


Theory of radioisotope scanning.

Theory of radioisotope scanning.


Techniques for the visualization of internal organs by an automatic radioisotope scanning system.


Estimation of the rates of uptake of Rb86 by the heart, liver and skeletal muscle of man with and without cardiac disease.


p-Iodobenzoyl groups as a paired label for in vivo protein distribution studies; specific localization of anti-tissue antibodies.


Beta-ray spectroscopy using a hollow plastic scintillator.


In search of bases of psychobiology: psychopharmacological and psychiatric notes.


Evaluation of a new oral antipruritic.

Evaluation of a new oral antipruritic.


Efficiency of barbiturate-nitrite ion action in angina pectoris.


Heredity and healing.

Heredity and healing.


Medical vignettes from Turkey.

Medical vignettes from Turkey.


Medical notes on Tibet.

Medical notes on Tibet.


The influence of fear and surgical procedures on the level of circulating eosinophils.


Electron microscopy of ultra-thin sections of lepra cells and Mycobacterium leprae.


Reserpine and human serum lepoproteins.

Reserpine and human serum lepoproteins.


Leprosy and tuberculosis: a comparative study with the aid of skin tests with tuberculin, killed BCG, and the Dharmendra lepromin in South African Bantus.


An inquiry into the significance of hallucinations with special reference to their occurrence in the sane.


Treatment of dermatoses with prednisolone aerosol.


Excitation of specific immune response in leprosy patients.


What every physician should know about homosexuality.


Treatment of office patients with prozine.


The contribution of William Hogarth to medical history.


Lymph nodes in leprosy.

Lymph nodes in leprosy.


Attempts to obtain an antigen (LPT) suitable for study of hypersensitivity in leprosy.


Principles of enrichment of foods.

Principles of enrichment of foods.


[The vitamin B1, vitamin B6 and nicotinic acid content of our bread].


The slow changes in potential during diastole.


The conservative management of heart disease complicating pregnancy.


Islet cell adenoma presenting as a psychiatric problem.


The level of the Colles fracture.

The level of the Colles fracture.


Coagulative properties of cancers.

Coagulative properties of cancers.


Tuberculin sensitivity in recurrent polyserositis (periodic disease).


Hemolytic trait in oriental Jews connected with an hereditary enzymatic abnormality of erythrocytes.


Partial hepatectomy as a stimulus to regeneration of the liver in experimental cirrhosis; preliminary report.


A comparative study of the sensitivity of Staphylococcus aureus to chloramphenicol and the tetracyclines.


Influence of microbial products on motility of human spermatozoa; preliminary report.


Ethnological study of the age trend of serum lipids; preliminary report.


The growth curve of Japanese encephalitis virus in the vector mosquito of Japan, Culex tritaeniorhynchus.


Studies on the experimental typhoid. 1. A comparative study of living and killed vaccines against the infection of mice with S. enteritidis.


On the carbohydrate metabolism of rat ascites hepatoma cells in tissue culture.


Additional observations on the appearance of some bird-parasitic trombiculid mites on the rockhead by the effect of breath; studies on tsutsugamushi. 102.


A fatal case of infantile pneumonia due to adenovirus; clinical findings.


A fatal case of infantile pneumonia due to adenovirus; pathological findings.


Intranuclear inclusion body in fatal infantile pneumonia due to adenovirus.


Isolation of an intermediate type of adenovirus from a fatal case of infantile pneumonia.


Human botulism and staphylococcal food poisoning: a review.


Type E (fish-borne) botulism: a review.

Type E (fish-borne) botulism: a review.


A cytopathogenic agent isolated from a case of an upper respiratory illness resembling an adenovirus infection.


Further studies of the cases associated with adenoviruses.


Studies on the effects of actinomycetes products on the culture of human carcinoma cells (strain HeLa). III. Comparative studies on anti-HeLa-cell effects of known synthetic antitumor substances.


Studies on the effects of actinomycetes products on the culture of human carcinoma cells (strain HeLa). IV. Studies on sarkomycin and its derivatives.


Studies on the brackish water cercariae in Japan. III. Three new echinostome cercariae in Tokyo Bay, with a list of Japanese echinostome cercariae (Trematoda).


Antitumor effect of 2-substituted benzimidazole on solid type of Ehrlich ascites tumor.


A recommendatory note for the control problem of schistosomiasis in China.


Epidemiological studies of A/Asia/1957 type influenza in a nursery near Tokyo City.


A new Salmonella type: Salmonella miyazaki (9, 12:1,z 13:1, 7).


On the cercaria of Centrocestus armatus (Tanabe, 1922) Yamaguti, 1933, especially on its mucoid gland (Heterophyidae, Trematoda).


The molluscicidal effect of sodium pentachlorophanate and calcium arsenite on Oncomelania hupensis, a snail host of Schistosoma japonicum in China.


Infection of the one-day old fertile hen's egg with rabies virus. III. Some observations on high egg passage (HEP) strains.


Infection of the one-day old fertile hen's egg with rabies virus. IV. A quantitative analysis of infective units for mice (MIU) and for one-day eggs (OIU).


Infection of the one-day old fertile hen's egg with rabies virus. V. Cultivation of different strains in the egg-white-replaced one-day egg (ERO) with special reference to interference between adult-mouse-pathogenic and nonpathogenic strains.


Changes in physiological activities of the HeLa strain cells growing in vitro.


Streptomycin and isoniazid in experimental guinea pig tuberculosis infected with kanamycin resistant tubercle bacilli.


Therapeutic effect of kanamycin upon advanced experimental tuberculosis of guinea pigs.


Oxygen consumption in relation to thermal sensation on cold exposure.


The diffusion of oxygen inside the red cell.


The dependency of the diffusing capacity on the HbO2 saturation of the capillary blood and on anemia.


The critical depolarization for the spike in the squid giant axon.


Study on the influence of high hydrostatic pressure on solutions by the use of an improved stationary platinum electrode polarography.


The influence of anions on the activity of gustatory receptors.


Notes on the seasonal variation of insensible perspiration in man.


Conduction of nervous impulses in NaCl-deficient media.


Brain-stem representation of jaw muscle activities of the dog.


Cognition without awareness: subliminal influences upon conscious thought.


A study of anxiety and learning in children.


The effects of different social feedback conditions upon performance in dyadic teams.


A comparison of interview and observation measures of mother behavior.


Neural satiation, reactive inhibition, and introversion-extraversion.


Body image and asymmetry of body reactivity.


Time orientation and interpersonal relations of emotionally disturbed and normal children.


The interaction of achievement motivation and ability in problem-solving success.


Failure and the subsequent performance of schizophrenics.


The effects of plausibility on the learning of controversial statements.


The expression and inhibition of hostility in imaginative and overt behavior.


Vicarious experience and partial reinforcement.


Size constancy as a function of personal adjustment and disposition.


Family patterns correlated with adolescent personality structure.


Some dynamic aspects of posthypnotic compliance.


A test of strain toward symmetry theories.


Marital satisfaction and husbands' and wives' perception of similarity in their preferred frequency of coitus.


A pure measure of perceptual defense uncontaminated by response suppression.


Perceived similarity and the projection of similarity: the influence of valence.


Future time perspective, optimism, and academic achievement.


Hysterics and dysthymics as criterion groups in the measure of introversion-extraversion: a rejoinder to Eysenck's reply.


The philosophy, principles and purposes of postgraduate medical education.


Idiopathic ventricular hypertrophy; a case report.


Experience with infectious meningo-encephalitis.


Primary carcinoma of the duodenum; a case report concerning a centenarian.


Sialography.

Sialography.


Fatal iproniazid (marsilid) hepatitis; a case report.


Anastomosis of coronary and internal mammary arteries; an experimental study.


New instruments for problems in optics.

New instruments for problems in optics.


MANAGEMENT of pathological vertebral fractures with paraplegia.


Buccal mucosal tests in patients with canker sores (aphthous stomatitis).


Histologic effects of silver nitrate of human dentin and pulp.


Experimental depletion of mononuclear cells for the purpose of investigating reactions of the allergic contact type.


Variations in egg white and egg yolk components of virus and rickettsial vaccines.


The occurrence of allergic disease in patients with Cushing's syndrome.


Photoelastic stress analysis of buccolingual sections of class II cavity restorations.


Microscopic investigation of root canal diameters.


Clinical experience with parabromdylamine maleate (dimetane), a new antihistaminic.


Cutting characteristics of an ultrasonic dental unit and various types of rotary burs.


Effect of roentgen-ray irradiation from a modern dental x-ray unit on the red and white blood cell count and on growth in the rat.


Permanent tooth mortality: a clinical study of causes of loss.


Microbiologic hazards of local dental anesthesia. II. Pilot study of involuntary aspiration of bacteria into hypodermic needles and anesthetic cartridges after injection.


Enhancement of histamine and anaphylactic shock in mice by Brucella abortus.


The dynamics of dentofacial growth and development relative to space maintenance.


New horizons in dentistry.

New horizons in dentistry.


The effect of foodstuffs on the pH of dental cavities.


The intramural practice plan in dental education; including a survey of American dental schools.


Hypersensitivity following ingestion of hydroxyzine (atarax) in a meprobamate-sensitive patient.


A case of extensive oral rehabilitation.


Asthma is a constitutional disease.

Asthma is a constitutional disease.


Removal of an impacted maxillary cuspid.


Studies in allergy. I. Serotonin, histamine, and antigen-antibody complex activity in isolated sensitized guinea pig uteri.


AMERICAN Dental Association statement on dentifrice advertising claims.


THE ILWU-PMA dental program: first year statistics. IV. The nine dental plans.


Is intrinsic asthma a reversible disease? A follow-up study.


Enzyme deficiency diseases. I. Galactosemia.


Enzyme deficiency diseases. II. Phenylketonuria.


Enzyme deficiency diseases. IIa. A phenylalanine-restricted diet.


The tuberculin, the Arthus, and the atopic allergic responses.


Diet and atherosclerotic disease. IV. Epidemiology of coronary heart disease in the United States.


Diet and atherosclerotic disease. V. Diet; a key, but not exclusive etiologic agent.


Fatty acid composition of food fats.

Fatty acid composition of food fats.


Sulfonylureas in diabetes mellitus.

Sulfonylureas in diabetes mellitus.


Current programs in nursing.

Current programs in nursing.


The teaching dietitian and nutrition research.


In-patient dietary instruction and the hospital setting.


Group discussion in changing food habits.


Cooling rate and bacterial growth in cornstarch pudding.


Nutrition following gastric resection.

Nutrition following gastric resection.


Nutritional condition of New Mexican children.


Calories and essential amino acids in an experimental diet.


Influence of nutrition teaching on adolescents' eating habits.


Nutritive value of the noon meal of nursery school children.


PANEL discussion on proper nutrition for the older age group.


Function of the postmenopausal ovary; comparison of urinary estrogen and gonadotropin excretion and response to administration of FSH in postmenopausal and ovariectomized women.


A new aid in the medical management of diverticulitis (300 cases).


A controlled clinical evaluation of dextropropoxyphene hydrochloride plus acetylsalicylic acid.


PANEL discussion on the management of allergies in geriatric patients.


Chemotherapy of choriocarcinoma and related trophoblastic tumors in women.


Irradiation cystitis.

Irradiation cystitis.


Pediatrics in transition.

Pediatrics in transition.


Serum transaminase activity in neonatal period: valuable and in differential diagnosis of jaundice in the newborn infant.


Brain abscess: a study of forty-seven consecutive cases.


Absorption of local anesthetics.

Absorption of local anesthetics.


Problem of the ruptured diaphragm.

Problem of the ruptured diaphragm.


Clinical importance of ureteral duplication and ectopia.


Advantages of cold conization: introduction of a new instrument.


Psychosis resulting from myxedema: report of a case.


Asteroid hyalitis: incidence of diabetes mellitus and hypercholesteremia.


NEW HORIZONS for the tuberculin test.

NEW HORIZONS for the tuberculin test.


IATROGENIC diseases in children.

IATROGENIC diseases in children.


SELECTING the place to practice.

SELECTING the place to practice.


Ectopic pregnancy-analysis of three hundred twenty-two consecutive cases, 1935-1954.


Surgical management of the tubal factor in infertility.


Chronic vesiculoprostatitis-a reorientation.


Physician relationships; problems related to public health, clinical practice, aging, and long-term illness.


Solitary pleural effusion due to myxedema.


Extra-articular arthrodesis of the subtalar joint (grice procedure); results in seventeen patients with cerebral palsy.


Narcotic withdrawal symptoms in newborn infants.


OLEANDOMYCIN phosphate.

OLEANDOMYCIN phosphate.


TRIACETYLOLEANDOMYCIN.

TRIACETYLOLEANDOMYCIN.


HEMOLYTIC and hypochromic anemia and elevated cold agglutinin titer in a seven-year-old child.


MEDICAL certification of absence from work.


A yardstick for testing hospital plans for disaster.


The premarital examination.

The premarital examination.


Subtotal cystectomy and total bladder regeneration in treatment of bladder cancer.


Preventive and aviation medicine in private practice.


Twenty-year study of physiological measurements in one hundred senior airline pilots.


Role of the human factors branch at the Air Force Flight Test Center.


Medical considerations of exposure to microwaves (radar).


Syncope in a population of healthy young adults; incidence, mechanisms, and significance.


Side-effects noted in treatment with methyl-prednisolone (medrol); report of seventy-seven consecutive cases.


Emergency commissurotomy in intractable pulmonary edema; report of two cases.


Therapeutic contributions of the doctor of physical medicine; application in the clinical practice of medicine.


Scrap iron intoxication.

Scrap iron intoxication.


Arterial thrombosis with gangrene after use of promazine (sparine) hydrochloride.


Subungual hemorrhage in pan washers; preliminary report.


MAMMARY carcinoma.

MAMMARY carcinoma.


DUMPING syndrome.

DUMPING syndrome.


PRELIMINARY guide for measuring work absence due to illness and injury.


UNION health centers, 1958 survey.

UNION health centers, 1958 survey.


Diagnosis of peripheral arterial emboli of the extremities.


Prevention of urinary calculi after paralytic poliomyelitis.


Examination for muscle weakness in infants and small children.


Treatment of thrombosis with fibrinolysin (plasmin).


Spinal anesthesia from the surgeon's standpoint.


Pharmacology of compounds used to produce spinal anesthesia.


Spinal anesthesia, arachnoiditis, and paraplegia.


Is heat sterilization of local anesthetic drugs a necessity?


SOME MEDICOLEGAL aspects of occupational dermatoses.


Electromyogram in evaluation of neurological complications of spinal anesthesia.


Staphylococcic endocarditis treated with ristocetin.


Interpretation of tests for intoxication.


The troubled employee.

The troubled employee.


CHILDREN in hospital.

CHILDREN in hospital.


WOE AND work.

WOE AND work.


ALABAMA community medical rating survey.


FINANCING the establishment of an office.


WHEAT at tuberculin P.P.D. test site associated with asthmatic attack.


Isolation stress in medical and mental illness.


Desirable athletics for children.

Desirable athletics for children.


Educational aspects of athletic for children.


Competitive athletics for children.

Competitive athletics for children.


Implications of longitudinal research in fitness programs.


Subdural hematoma in the elderly person.


Importance of autopsies-an illustrative case.


THE PURPOSE of a medical school.

THE PURPOSE of a medical school.


Medical education in the United States and Canada; fifty-eighth annual report on medical education in the United States and Canada by the Council on Medical Education and Hospitals of the American Medical Association.


THE FULL-TIME faculty deficit.

THE FULL-TIME faculty deficit.


BALANCES to be considered in international educational exchange of medical students.


FUNNEL chest.

FUNNEL chest.


Role of ureter in pathogenesis of ascending pyelonephritis.


Diagnosis and management of the rare causes of gastrointestinal hemorrhage.


Rehabilitation of the patient with long-term respiratory paralysis.


The patient and physician in cardiac symptom formation; anginal syndrome.


Cardiac arrhythmias in experimental syncope.


Experience with medicare.

Experience with medicare.


Hematuria in boxers.

Hematuria in boxers.


Surprising growth of voluntary health insurance in Great Britain.


Effect of prednisone in the treatment of malignant effusions.


Unique movable footrest for elevation of the lower extremity.


An overwhelming strongyloides infection.


Oral medication with preparations for prolonged action.


Nutritional state of the mother prior to conception.


DYSMENORRHEA.

DYSMENORRHEA.


Missiles or pensions.

Missiles or pensions.


Safety of liquid plasma: a statistical appraisal.


The physician himself.

The physician himself.


Research on human factors of aerial warfare.


Psychiatric problems and preferences for instruction; an appraisal of reports by three hundred thirty-eight general practitioners.


Whiplash injuries; neuro-physiological basis for pain and methods used for rehabilitation.


Etiological factors in first-degree murder.


Jejunal interposition operation; analysis of thirty-three clinical cases.


Direct coronary artery perfusion for aortic valve surgery; report of technique.


Intoxication from primidone due to its biotransformation to phenobarbital.


RABIES vaccine (duck embryo).

RABIES vaccine (duck embryo).


SULFAMETHOXYPYRIDAZINE.

SULFAMETHOXYPYRIDAZINE.


ACETYL sulfamethoxypyridazine.

ACETYL sulfamethoxypyridazine.


TRIFLUPROMAZINE hydrochloride.

TRIFLUPROMAZINE hydrochloride.


USE OF nicotinic acid in hypercholesteremia.


Maternal nutrition and the fetus.

Maternal nutrition and the fetus.


GENERALIZED abdominal pain and acute renal failure.


RISK OF hepatitis reduced.

RISK OF hepatitis reduced.


MISCONCEPTIONS about eyeglasses.

MISCONCEPTIONS about eyeglasses.


Noah Webster; epidemiologist.

Noah Webster; epidemiologist.


Panel on physician in role of adviser.

Panel on physician in role of adviser.


Panel on emotional health of women.

Panel on emotional health of women.


Enuresis.

Enuresis.


Evolution and significance of cardiovascular changes associated with hypertension; analysis of 100 cases of essential hypertension.


Arthrodesis versus arthroplasty of the hip.


The chronic brain syndrome.

The chronic brain syndrome.


Care of the female patient with genital malignancy.


The importance of exchange transfusions in the treatment of hyperbilirubinemias of the newborn.


Arteriosclerosis obliterans; its surgical repair.


Addison's disease; with report of a case.


The Medicare patient.

The Medicare patient.


Comes the dawn.

Comes the dawn.


The use of prednisolone tertiary-butylacetate in general practice.


Degenerative disease: enigma? challenge, opportunity.


Submucous resection.

Submucous resection.


Subclinical signs of trauma.

Subclinical signs of trauma.


The effects of tolbutamide on beta cell function.


Whiplash injuries of the cervical spine un-associated with fracture or neurologic symptoms.


The Federal Government and the health of the Nation.


The synthesis and antifungal properties of 6-fluorothymol.


The effect of pH on the efficiency of various mold inhibiting compounds.


Tragacanth solutions. III. The effect of pH on the stability.


A mathematical interpretation of the kinetics of elevated temperature stability studies as applied to solid formulations.


An inverse isotope dilution analysis of salicylic acid.


The effect of zinc acetate on red corpuscles.


Isotonic solutions. VI. The permeability of red corpuscles to various salts of organic acids.


Isotonic solutions. VII. The permeability of red corpuscles to various alkaloidal salts.


Fluorescence of powdered vegetable drugs under ultraviolet radiation.


The pharmacology of some bis-quaternary ammonium compounds.


The culture of Claviceps purpurea. IV. Lipogenesis.


Degradation of epinephrine induced by bisulfite.


Colorimetric estimation of some cholinergic esters; application to the demonstration of acetylcholinesterase activity.


The sterol and triterpene content of the Labiatae family.


The pharmacologic actions of the bronchodilator drug, isoetharine.


Dialkylaminoalkyl esters and amides derived from 3-hydroxy-and 3-alkoxy-2-naphthoic acids.


Examination of the physical chemical basis for the isoniazid-p-aminosalicylic acid combination.


Sulfaethylthiadiazole. IV. Steady state blood concentration and urinary excretion data following repeated oral doses.


A note on the extraction and fluorescence of some oxidation products of reserpine.


A note on the use of the Brookfield RVF viscometer with thickening agent dispersions.


A note on the photosensitivity of phenothiazine derivatives.


Purification of fructose on ion exchange resins.


Correlation between anticonvulsant activity and plasma concentration of ethanol.


The kinetics of the base-catalyzed degradation of prednisolone.


The pharmacology of two structurally isomeric mono-phenyl substituted 1, 2, 4-triazoles.


A thermistor thermometer and direct-reading isotonicity meter.


Studies on antacids. VI. Adsorption effects of various aluminum antacids upon some simultaneously administered synthetic anticholinergic drugs.


Some factors influencing the saprophytic production of clavine alkaloids by Claviceps purpurea.


Synthesis and biotesting of metallic surfactants.


A study of the anthelmintic activity of some lactones and peroxides.


The synthesis and proof of structure of N-alkylated oxadiazolones.


The effects of atropine and 2, 4-dichlorophenoxyacetic acid on leaf alkaloid accumulation in certain members of the Solanaceae.


Preservative action of combined bacteriostatic agents. I. Preservative action of chlorobutanol in combinations with certain other bacteriostatic agents.


The effect of hydrogen ion and alcohol concentration on the solubility of phenobarbital.


Stress resistance in thymectomized rats.


An investigation of the blood coagulating principles from Ceanothus americanus.


The flavonoid constituents of Amphiachyris dracunculoides (DC) Nutt.


The application of ultrasonic energy to the extraction of belladonna leaf U.S.P.


An investigation of the possible potentiation of ethinamate activity by chlorpromazine.


Comparative activities and toxicities. II. Sugar and amino acid derivatives of bis-(4-aminophenyl)-sulfone.


A note on several new alkaloids from Vinca rosea Linn. I. Leurosine, virosine, perivine.


The case against the indiscriminate use of the moulded shoe.


Compensatory balancing of footgear to alter weight transmission.


Foot indices; heel-to-ball and ball-to-toe measurements.


Some comments on the definition of pes planus and shoe flare.


The role of the medical professions and the shoe industry in America's youth foot-health fitness program.


A simplified method of fabricating a balance inlay.


A new therapeutic approach for accommodation of foot pathology.


Office fabrication of a conventional moulded shoe.


The office fabrication of balance appliances.


A contour molded shoe of conventional appearance.


Allergic dermatitis: a case report.

Allergic dermatitis: a case report.


Surgical removal of a lipoma from a fourth toe.


Surgical removal of a medial sesamoid.

Surgical removal of a medial sesamoid.


Corticosteroid injections in the foot.

Corticosteroid injections in the foot.


The strengthening of chronically strained ankle ligaments with injections of sodium psylliate.


Reactions to injected drugs and their emergency care.


Rationale of corticosteroids and their derivatives.


Parenzyme injection for plantar warts; a preliminary report.


Office management of intermetatarsal neuralgias.


Podiatry and public health.

Podiatry and public health.


A sterile disposable syringe.

A sterile disposable syringe.


Foreign body of glass; a case report.

Foreign body of glass; a case report.


Surgical correction of retrocalcaneal bursitis (Haglund's disease).


Surgical correction of osteomyelitis fifth toe.


Pre-body-ego types of (pathological) mental functioning.


Early physical determinants in the development of the sense of identity.


Disturbances in abstract thinking and body-image formation.


Abstract thinking and object relations with special reference to the use of abstraction as a regressive defense in highly gifted individuals.


Dream resistance and schizophrenia.

Dream resistance and schizophrenia.


Some observations on hog cholera and its control in the United States.


Treatment of chronic canine otitis externa by ablation of the ear canal.


A new and versatile operating table.

A new and versatile operating table.


Additional studies of fibular defects in horses.


Chemical identification of Crotalaria poisoning in horses.


Keratoconjunctivitis in the goat.

Keratoconjunctivitis in the goat.


Studies on the use of Illini variable temperature semen diluent in beef cattle.


The fertility of frozen bovine semen packaged under carbon dioxide.


Salmonellosis in poultry and poultry processing plants in Western Pennsylvania.


Coccidioidomycosis; report of a disseminated case in a dog.


Radiology in the diagnosis of canine thoracic ailments.


Traumatic chylothorax in small animals treated by ligation of the thoracic duct.


Recovery of a heifer with tetanus.

Recovery of a heifer with tetanus.


Observations on effect of preanesthetic medication with meperidine and promazine on barbiturate anesthesia in an ocelot and a leopard.


A method for graphic measurement of the physical forces and differential pressures in mechanical milking systems.


A study of penicillin tolerance of some organisms infecting the bovine mammary gland.


Cleft lip and palate in the dog.

Cleft lip and palate in the dog.


The veterinarian and the guide dog.

The veterinarian and the guide dog.


The early development of the brain in marsupials; preliminary communication.


The factors controlling the development of the dorsal root ganglia and ventral horn in Xenopus laevis (Daud.).


The capsule of spinal ganglion cells.

The capsule of spinal ganglion cells.


The structures of fast and slow muscle fibres in the frog.


The association of alkaline phosphatase with fibrogenesis.


The histochemical appearances of cholinesterase in the parasympathetic nerves supplying the submandibular and sublingual salivary glands of the rat.


Acrocephalo-oligodactylism in a wild chimpanzee.


The behaviour of autografts of ileum transplanted into the urinary bladder in rabbits.


Studies on hair growth in the rabbit.

Studies on hair growth in the rabbit.


Some anatomical features of the mandible.


The tubercle of the tibia.

The tubercle of the tibia.


The tendons of flexor digitorum profundus.


The evolution of some traction epiphyses in birds and mammals.


The oblique cord of the forearm.

The oblique cord of the forearm.


The ligamentous structures in the canalis and sinus tarsi.


The serial sectioning of undecalcified animal heads.


IN MEMORIAM: James Couper Brash.

IN MEMORIAM: James Couper Brash.


Biological studies on mikamycin.

Biological studies on mikamycin.


A relation between the inhibitory activities on tumor-cells and those on Ascarisova of the products of Streptomyces.


Virocidin, a new antiviral and antibacterial antibiotic.


Cyanomycin, a new antibiotic.

Cyanomycin, a new antibiotic.


Studies on kanamycin. II. Structural evidence for mono-o-(methyldeoxystreptamine.


Purification and isolation study on gancidins.


Reduction of viability duration of Mycobacterium tuberculosis produced by subinhibitory concentrations of antituberculous drugs.


Studies on actinoleukin; relation to echinomycin and levomycin.


Chemistry of kanamycin. IV. The configuration of the compound C.


Structure studies on kanamycin.

Structure studies on kanamycin.


Chemistry of kanamycin. V. The structure of kanamycin.


Effects of cervical vagotomy on pulmonary ventilation and mechanics.


Changes in respiratory response to CO2 during natural sleep at sea level and at altitude.


Relationship between maximum expiratory flow and degree of lung inflation.


Pressure-volume measurements on dog bronchi.


Mechanical aspects of the first breath.

Mechanical aspects of the first breath.


Relation between mechanics of respiration, lung size and body size from birth to young adulthood.


Oxygen transport, utilization & storage in rats acclimated to altitude at different temperatures.


Partitional respirometry in human subjects.


In vitro and in vivo effects of inositol phosphatide (lipositol) fraction of soybean on serum lipids and lipoproteins.


Human endogenous plasma lipemia clearing activity, observations in 482 individuals.


Dog's isolated hind limb preparation as a suitable method for the study of hemostasis.


Erythrocyte hydration under positive acceleration.


Reversible cessation of blood circulation in deep hypothermia.


Acid-base relations between spinal fluid and arterial blood with special reference to control of ventilation.


Hemodynamic effects of cardiac glycosides on normal human subjects during rest and exercise.


Relationship of platelet factor 1 and platelet fibrinogen to plasma.


Effect of administration of phenindione on blood levels of prothrombin, autoprothrombin I and autoprothrombin II.


Effect of cold on the isolated and intact rabbit heart.


Strenuous exercise in a hot environment.


Physiological characteristics in relation to climatic preference.


Effect of local cold application on the fusion frequency of flicker.


Comparison of the stimulation of the warmth sense organ by microwave and infrared.


The experimental approach to pain.

The experimental approach to pain.


Spatial summation of pain.

Spatial summation of pain.


Effects of dehydration, physical conditioning and heat acclimatization on the response to passive tilting.


Analysis of two-handed pulls using free body diagrams.


Measurement of endoesophageal pressure.

Measurement of endoesophageal pressure.


Local factors in the pathogenesis and course of experimental ascites.


Lactic acid concentration of brain tissues of dogs exposed to hypoxemia and/or hypocapnia.


Influence of spermatozoal concentration and initial fructose level on fructolysis in human semen.


Direct graphical representation of helium katharometer indicator and other galvanometer readings.


A simple device for rapid serial collection of anaerobic blood samples.


A portable heart rate recorder.

A portable heart rate recorder.


Effect of acetazoleamide (diamox) on thyroid function.


Electrodes for blood pO2 and pCO2 determination.


A multi-purpose radioopaque catheter for simultaneous blood sampling, pressure recording and temperature measurement.


A simple, efficient beta ray counter for liquid samples.


An evaluation of siliclad; a new silicone material.


Precautions in the physiological application of thermistors.


Effect of addition of fructose and of glucose on the fructolysis and motility of human semen.


The diagnosis and treatment of non-penetrating wounds of the abdomen.


Histoplasmosis in Arkansas.

Histoplasmosis in Arkansas.


Levator muscle surgery.

Levator muscle surgery.


Medicine.

Medicine.


Kernicterus, a preventable disorder.

Kernicterus, a preventable disorder.


HEARING testing program in Arkansas schools.


The pathology of chronic ulcerative colitis.


Fistulotomy versus fistulectomy.

Fistulotomy versus fistulectomy.


Problems of a mass screening program for uterine cancer in Arkansas.


THE PHYSICIAN'S role in the social security disability program.


The importance of the toxin theory in small bowel obstruction.


The aeromedical realities of space travel.


Behavioral effects of whole body vibration.


Impact thresholds of brain concussion.

Impact thresholds of brain concussion.


Vertebral fractures in survivors of military aircraft accidents.


The prevention of refractive visual defects in aging airline pilots.


The effect of hypoxia on tolerance to positive acceleration.


Relation of injury to forces and direction of deceleration in aircraft accidents.


The spatial vectorcardiogram during acceleration.


Effects of hyperventilation on speech and hearing.


Partial denaturation of a bacterial aldolase without loss of activity.


Study of surface characteristics of Hansenula yeasts by agglutination techniques: use of methylene blue, acid and metallic ions.


Role of hyaluronidase and the hyaluronic acid capsule in the survival and dissemination of group A streptococci in the hamster cheek pouch.


Effect of deoxycorticosterone on the growth of microorganisms.


Characterization of intracellular, glucosidic polysaccharide produced by Brucella suis.


Inhibition of a collagenase by the human gingival microbiota.


Toxic effect of glucose on virulent Pasteurella pestis in chemically defined media.


Chemically defined media for synnematin production.


Sulfur metabolism of synnematin-producing molds.


Comparative study of the binding of synnematin and penicillin by bacterial cells.


Sulfate utilization by penicillin-producing mutants of Penicillium chrysogenum.


Growth-factor-dependent strains of Salmonellae.


Fine structure of microorganisms. III. Electron microscopy of resting and germinating ascospores of Saccharomyces cerevisiae.


Toxins of Pseudomonas pseudomallei. I. Production in vitro.


Toxins of Pseudomonas pseudomallei. II. Characterization.


Studies on mixed infections. III. Influence of immunological factors in combined Brucella suis and Coxiella burnetii infection.


Differential diagnosis of Pseudomonas-like microorganisms in the clinical laboratory.


Preservation of cultures by drying on porcelain beads.


Colonial variation of Pasteurella haemolytica isolated from sheep.


Improved medium for selective isolation of Veillonella.


Medium for the differentiation of acid producing colonies of staphylococci.


A role for biotin in yeast glycolysis.

A role for biotin in yeast glycolysis.


Biochemical studies of the developing avian embryo. II. Enzymes of the citric acid cycle.


Synthesis of a beta-1, 3-linked glucan by extracts of Phaseolus aureus seedlings.


Aldono- and uronolactonases of animal tissues.


Pyruvate metabolism. II. Restoration of pyruvate utilization in heart sarcosomes by alpha-(+)-lipoic acid.


The presence of phosphatidic acid in animal tissues.


Phosphoinositides and protein secretion in pancreas slices.


Phospholipides and adrenaline secretion in guinea pig adrenal medulla.


Phospholipides and the secretion of adrenocorticotropin and of corticosteroids.


Acetylcholine and the exchange of inositol and phosphate in brain phosphoinositide.


Acetylcholine and the exchange of phosphate in phosphatidic acid in brain microsomes.


Anhydrovitamin A2 and rehydrovitamin A2.


In vivo incorporation of diethanolamine into liver lipides.


On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. VI. Isolation and properties of stable enzyme-substrate complexes.


Composition and concentration of lymph and serum lipoproteins during fat and cholesterol absorption in the dog.


On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. VII. The nature of the green color of butyryl dehydrogenase.


A study of the quantitative estimation of ethanolamine and serine in phospholipides.


The specific distribution of fatty acids in the glycerides of animal and vegetable fats.


On the transformation and enterohepatic circulation of cholic acid in the rat: bile acids and steroids 68.


3 alpha-Hydroxysteroids as coenzymes of hydrogen transfer between di- and triphosphopyridine nucleotides.


Presence of a glucagon-like material in blood of man and dog.


Studies of hog kidney acylase I. I. Comparison with hog kidney dialkylfluorophosphatase.


Studies of hog kidney acylase I. II. Some aspects of substrate specificity.


The biosynthesis of spermidine and spermine from putrescine and methionine.


Identification of alpha- and beta-melanocyte-stimulating hormone in hog posterior pituitary powder.


Studies of the specificity of deoxyribonuclease I. I. Hydrolysis of a trinucleotide.


Chemical composition of epiphyseal plate of long bones: content of amino acids.


The biosynthesis of heme and the incorporation of glycine into globin in rabbit bone marrow in vitro.


The enzymatic degradation of urocanic acid.


Further studies on the pathways of synthesis of thymine compounds by lymphatic tissues and tumors.


Glutamate as a precursor for the pyrrolidine ring of nicotine.


On the activity of cystine desulfurase in mouse tumors.


Phosphorus compounds in animal tissues. VI. Deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine in the Novikoff hepatoma.


Pyridine nucleotide metabolism: mechanism of action of the niacin antagonist, 6-aminonicotinamide.


Nucleoside tri-phosphates as precursors of ribonucleic acid end groups in a mammalian system.


Studies in vivo on the conversion of folic acid to citrovorum factor.


Enzymatic reduction of dihydrofolic acid.


The hydrolytic activity of glyceraldehyde-3-phosphate dehydrogenase.


Enzymatic reactions involving sulfate, sulfite, selenate, and molybdate.


Formation of tetralin-p-quinol and a protein-bound derivative from tetrahydro-2-naphthol-8-C14 by rat liver microsomes.


The non-enzymatic decarboxylation of diketosuccinate and oxaloglycolate (dihydroxyfumarate).


alpha-Glycerophosphate oxidase of flight muscle mitochondria.


Studies on the mechanism of the enzymatic amination and hydration of fumarate.


Enzymatic basis of resistance to aureomycin. II. Inhibition of electron transport in Escherichia coli by aureomycin.


The stereospecificity of the aspartase reaction.


Photography of the eye.

Photography of the eye.


Photographing of disease symptoms of leaves.


Some recent advances in microscopy. III. Photomicrography.


Analysis of cinema films in diagnosis and research.


A simplified technique for high speed flash photography with the phase microscope.


Ways and means of reducing your operating expenses.


Serial observations on patterns of growth, myelin formation, maintenance and degeneration in cultures of new-born rat and kitten cerebellum. New-born rat and kitten cerebellum may be maintained for prolonged periods (over 5 months) in the Maximow assembly if explanted on to a coverslip previously coated with a thin gel of reconstituted rat tail collagen and fed a glucose-enriched "natural" medium. After a 2 week period of adjustment and early outgrowth, most cultures exhibit myelin formation. Axons located within the surrounding neuroglial sheet of the explant area myelinate. The sheaths are first evident as long, unsegmented, smooth, parallel, refractile lines. Simultaneously, neuronal nuclei tend to assume central positions and powdery granules of Nissl substance and lipoid materials begin to accumulate within the cytoplasm. During prolonged maintenance, axons may increase in width and the myelin may thicken. Some exhibit transient irregularities and swellings. Degeneration of some axons occurs manifested either by (a) progressive swellings and distortions of the myelin sheath and thinning of intervening portions of the axons which finally yield, leaving the swellings as myelin bodies, or by (b) small aneurysm-like distortions of myelin sheaths on thinning axons which become dull, irregular, and thread-like filaments beaded by the former herniations. The observations are compared with previous studies of in vitro and in vivo myelin formation with particular reference to neuronal-neuroglial relationships.


Structural characteristics of developing Nitella internodal cell walls. The Nilella intermodal cell is formed by a division of the segment cell, the latter being a direct derivative of the shoot apical cell. The internodal cell is remarkable in that it elongates from an initial length of about 20 microns to a mature length of about 60 millimeters. The structures of the apical and segment cells, and the internodal cells in all stages of development were examined with the techniques of interference, polarization, and electron microscopy. The apical and segment cells were found to be isotropic. The upper part of the segment cell, destined to form a node, shows a curious pitted structure that was characteristic of certain node structures. The lower part of the segment cell, destined to become an internodal cell, shows a vague transverse arrangement of fibrils at the inner wall surface. The internodal cells, from the time they are first formed, show negative birefringence and a transverse arrangement of microfibrils at the inner wall surface. The elongation of the internodal cell is characterized by a rise, dip, and rise in both the optical thickness and retardation of the cell wall. The dip in both these variables coincides with the attainment of the maximum relative elongation rate. After the cessation of elongation, wall deposition continues, but the fibrils at .the inner surface of the wall are now seen to occur in fields of nearly parallel microfibrils. These fields, with varying fibrillar directions, may partly overlap each other or may merge with one another. Unlike the growing wall, this wall which is deposited after the end of elongation is isotropic.


An anterior-posterior gradient of refractive index in the ameba and its significance in ameboid movement. Sustained locomotion in Amoeba proteus and Amoeba dubia results in the establishment of a measureable gradient of refractive index along the anterior-posterior axis of the cell, provided thickness of the specimens is kept constant by even compression under a selected coverglass supported by quartz beams of uniform diameter. The tail region of the ameba develops a higher refractive index, indicative of from 6 to 40 per cent more organic matter (expressed as protein) there than present in the front. This gradient fades on cessation of movement. The average protein concentrations in the crystal-free tails and fronts of 15 A. proteus were 3.9 and 3.4 per cent, respectively. In individual experiments, the tail-front difference ranged from one to eight times the accuracy of the method. Since the gradient of refractive index was shown not to result from extraction of water from the tail by the contractile vacuole, it was interpreted as displacement of water toward the anterior part of the cell during movement. It is suggested that contraction of the ectoplasm drives forward a "tide" of syncretic fluid, the anterior border of which is visible as the hyaline cap, which contains less than 1 per cent protein. The movement of the granular endoplasm into the hyaline cap would then complete the cycle by imbibition of the fluid tide. The theoretical positions of Pantin and of Dellinger have been combined in the proposal that ameba cytoplasm consists of a network of a contractile phase which is able to expel (by syneresis) a highly mobile fluid phase. Some other possible interpretations are discussed.


The role of carbon dioxide as an essential nutrient for six permanent strains of fibroblasts. The results of these studies demonstrate that carbon dioxide is required for the growth and maintenance of strains of fibroblasts derived from human tissues, strains FS4-705 and U12-705, from mouse tissue, strain L-705, and from rabbit tissues, strains RM3-56, RS1-56, and RT-56 in a chemically defined medium containing phosphite buffer in place of bicarbonate and supplemented with dialyzed serum and dialyzed embryo extract. Under these conditions, the cells fail to proliferate at a significant rate and begin to degenerate within 5 to 10 days when the flasks are not stoppered. Sufficient carbon dioxide is produced by the cells to promote growth as indicated by the fact that maximal proliferation is obtained in the same phosphite media when stoppered flasks are employed. With the exception of RS1-56, all the remaining strains tested can be propagated serially in open flasks containing phosphite medium prepared with whole serum and embryo extract. The rate of growth under these conditions, however, is only one-half to one-third that obtained in stoppered flasks containing phosphite medium or the conventional bicarbonate medium.


A diamond knife holder for microtomes designed to take glass knives.


The fine structure of the interrelationship of cells in the human epidermis. In the present investigation an analysis has been made of the fine structure of the interrelationships of cells in human forearm epidermis by means of the electron microscope. The "intercellular bridges," here called attachment zones, are more complex than has previously been recognized. It is shown that dense oval thickenings, called attachment plaques, appear in apposed areas of adjacent epidermal cell membranes. The tonofibrils terminate at the internal face of the attachment plaque and do not traverse the 300 A distance between apposed plaques. Seven intervening layers of unidentified substance occupy the space between attachment plaques. The attachment zones appear in all of the classical histological layers of the epidermis. The portions of epidermal cell membrane not involved in intercellular attachments have extensive surface area resulting from plication of the membrane, and its further modification to form microvilli. The possible functional significance of these observations is discussed. Prior observations concerning the basement membrane of epidermis are confirmed. Identification of epidermal melanocytes is achieved, the finer morphology of their dendritic processes is described, and their relationship to epidermal cells is discussed.


Colorimetric analysis with N, N-dimethyl-p-phenylenediamine of the uptake of intravenously injected horseradish peroxidase by various tissues of the rat. 1. A method is described for the colorimetric determination of peroxidase with N,N-dimethyl-p-phenylenediamine. The amount of red pigment formed by peroxidase is proportional to the concentration of enzyme and to the time of incubation during the first 40 to 90 seconds. The influence of the concentration of enzyme, N,N-dimethyl-p-phenylenediamine, H(2)O(2), the time of incubation, pH, the temperature, and the possible interference by oxidizing and reducing agents of tissues has been tested. 2. The method has been used to follow the uptake of intravenously injected horseradish peroxidase by 18 different tissues of the rat over a period of 30 hours. The highest concentration of the injected tracer enzyme was found in extracts of kidney, liver, bone marrow, thymus, and spleen. Considerable amounts were taken up by pancreas, prostate, epididymis, and small intestine. Lower concentrations were found in extracts of lung, stomach, heart, and skeletal muscle, aorta, skin, and connective tissue. No uptake was observed by brain and peripheral nerve tissue. 3. Tissue homogenates containing high concentrations of the injected peroxidase, in general also showed high or average activity of acid phosphatase. 4. Six hours after intravenous administration, the liver contained 27 per cent, the kidney 12 per cent, and the spleen, 1.4 per cent of the injected dose. 5. Approximately 20 per cent of the injected peroxidase was excreted in the urine during the first 6 hours, and the concentration of peroxidase in blood serum and urine fell exponentially during this time. After 6 hours, only low concentrations were excreted in the urine but low enzyme activity was still detectable after 30 hours. Approximately 6 per cent of the injected dose was excreted in the feces from 6 to 20 hours after administration. 6. After feeding through a stomach tube, low concentrations of peroxidase were found in blood serum and urine. Considerable variations in the extent of absorption from the gastrointestinal tract were observed in individual rats.


The early changes in the axoplasm during wallerian degeneration. Axoplasmic changes were studied in the saphenous nerve of the albino rat during the early stages of Wallerian degeneration. The axons were examined at 0, 24, and 48 hours after the surgical transection of the nerve. The material was fixed in 2 per cent OsO(4) in phosphate buffer (pH 7.2-7.5) with sucrose (added to a final osmolar concentration of approximately 0.37 M). The earliest changes were seen in the endoplasmic reticulum which became fragmented into rows of small vesicles. Then, between 24 and 48 hours, the neurofilaments underwent complete disintegration and the axoplasm became filled with finely granular material which later formed irregular clumps surrounded by a structureless matrix, probably fluid in vivo. The fragmentation of the neurofilaments was accompanied by pronounced swelling of the mitochondria.


A cyto-chemical study on the pancreas of the guinea pig. III. In vivo incorporation of leucine-1-C14 into the proteins of cell fractions. DL-leucine-1-C(14) was administered by intracardiac injection to guinea pigs and its in vivo incorporation into the proteins of various pancreatic cell fractions followed over a period of 2 hours. The pancreas was homogenized in 0.88 M sucrose and fractionated by differential centrifugation to give nuclear, zymogen, mitochondrial, microsomal, postmicrosomal, and final supernatant fractions. The proteins of these fractions, obtained by precipitation with trichloroacetic acid followed by washing, were counted. The proteins of the microsomal fraction showed the highest early specific activity and were followed by those of the zymogen and mitochondrial fractions. The microsomal fraction was broken up into two subfractions: one consisting of detached RNP particles, the other representing mainly the microsomal content and membranes. The incorporation of labelled leucine into the proteins of microsomal subtractions and in those of postmicrosomal fractions was studied comparatively in the pancreas of fasted and fed guinea pigs as well as in the liver and pancreas of fasted animals. A tentative cytological picture of protein synthesis and transport based on these findings is presented.


The arginase and rhodanese activities of certain cell strains after long cultivation in vitro. The activities of the enzymes arginase and rhodanese were examined in homogenates of 13 mouse cell strains and 2 human cell strains after long cultivation of the cells in vitro. Three strains of mouse liver origin showed both high arginase and rhodanese activities in keeping with activities of the tissue of origin. Two strains of cells of human epithelial origin, HeLa and epidermis, were found to have high rhodanese activity but low arginase activity, the skin being almost devoid of it. Seven mouse fibroblast strains or substrains had moderate rhodanese activity and all except one of the strains had low arginase activity. Two of the fibroblast strains tested, NCTC 1745 and NCTC 2050, were derived from a single cell of a tumor appearing after injection of the high tumor producing strain NCTC 1742 into a mouse. The strain 1745 had 20 times and the strain 2050 had 400 times the arginase activity of the parent strain of cells. The findings imply a considerable biochemical variation in the three strains. Three mouse mammary carcinoma clones were devoid of arginase activity, but had considerable rhodanese activity.


Some observations on the fine structure of the sinus gland of a land crab, Gecarcinus lateralis. The dilated axon endings of the sinus glands of the brachyuran crab, Gecarcinus lateralis, are filled with homogeneously dense granules, each granule being bounded by a delicate membrane. The granules are of two orders of magnitude: 0.05 to 0.1 micro and 0.15 to 0.2 micro in diameter. Each axon ending contains granules of a nearly uniform size. Endings with granules of the larger size range predominate. Non-nervous cells endogenous to the sinus gland are scattered among the nerve endings. The cell contours are irregular, and cytoplasmic processes ramify between endings. The axons are unmyelinated, having only thin limiting membranes, and they possess many neurofibrils. Granules in preterminal portions of the axons tend to lie at the periphery of the fiber, and in some cases in chains at the core of the fiber. The granules appear to be storage and release centers for neurosecretory substances or their precursors.


Cytochemical localisations and ultrastructure in the fertilized unsegmented egg of Paracentrotus lividus. Fertilized, but still unsegmented, eggs of the sea urchin Paracentrotus lividus have been centrifugated at 30,000 gravity. A comparison has been made between the cytochemical reactions of the different layers (RNA, polysaccharides, acid phosphatase) and the fine structure as shown in thin sections studied with the electron microscope.


The contribution of lower oxides of osmium to the density of biological specimens in electron microscopy. Centrifugally stratified eggs of the sand-dollar, Dendraster excentricus, have cytoplasmic structures segregated into distinct layers. Fat droplets, yolk granules, and mitochondria are separated by "hyaline" layers of protoplasm. Aggregations of particles of 150 to 200 A diameter ("heavy bodies") are found near the mitochondrial layer and a concentration gradient of free 150 to 200 A particles corresponds to a similar gradient of basophilia in thick sections. Eggs fixed in buffered osmium-tetroxide at pH 7.4 and embedded in methacrylate were sectioned and floated on a "bleaching" solution of acidified hydrogen peroxide. "Bleached" sections showed a considerable loss in general density and especially a loss in the sharp images of cellular membranes. It was shown that such loss is not due to sublimation of structure in the electron beam. Assuming that the "bleach" acts principally to reoxidize lower oxides of osmium, it was concluded that reduced and bound lower oxides of osmium play a major role in creation of the electron micrograph image, especially in the delineation of phospholipide components of cellular membranes. Particles of 150 to 200 A diameter showed little or no loss in density, but rather a high intrinsic electron density. Refractometric data were presented to substantiate the tentative conclusions.


The fine structure of blastema cells and differentiating cartilage cells in regenerating limbs of Amblystoma larvae. Regenerating forelimbs of larval salamanders, Amblystoma punctatum, were fixed in OsO(4) at various intervals after amputation and were sectioned for study with the electron microscope. The dedifferentiated cells comprising the early blastema were found to have a fine structure similar to that of other undifferentiated cells and to have lost all of the identifying morphological features of their tissues of origin. The cytoplasm of such cells is characterized by numerous free ribonucleoprotein granules and a discontinuous vesicular endoplasmic reticulum. The cells have more abundant cytoplasm and are in closer contact with each other than was previously realized. The layer of condensed ground substance investing most differentiated cell types is lacking. After a period of rapid cell division, the morphology of the blastema cell changes. Cytoplasm is now sparse and contains a high concentration of free ribonucleoprotein granules, but little endoplasmic reticulum. The differentiating cartilage cell, however, develops an extensive, highly organized endoplasmic reticulum and the Golgi apparatus also appears to become more highly differentiated and more extensive at this time. Small vesicles appear throughout the cytoplasm at the time the new cisternae originate and may contribute to their formation. These and other changes in the cytoplasmic organelles are discussed.


Methods and principles of fixation by freeze-substitution. Freeze-substitution is based on rapid freezing of tissues followed by solution ("substitution") of ice at temperatures well below O degrees C. A 1 to 3 mm. specimen was thrown into 3:1 propane-isopentane cooled by liquid nitrogen to -175 degrees C. (with precautions). The frozen tissue was placed in substituting fluid at -70 degrees C. for 1 week to dissolve ice slowly without distorting tissue structure. Excess substituting agent was washed out, and the specimen was embedded, sectioned, and stained conventionally. For best morphological and histochemical preservation, substituting fluids should in general contain both chemical fixing agent and solvent for ice, e.g., 1 per cent solutions of osmium tetroxide in acetone, mercuric chloride in ethanol, and picric acid in ethanol. Preservation of structure was poorer after substitution in solvent alone. Evidence was obtained that the chemical agent fixes tissue at low temperatures. The chemical mechanisms of fixation are probably similar to those operating at room temperature: new chemical cross-linkages, which contain the fixing agent, join tissue constituents together. This process is distinguished from denaturation by pure solvents. Freeze-substitution has many advantages, particularly the preservation of structure to the limit of resolution with the light microscope, and the accurate localization of many soluble and labile substances.


The fine structure of the adipose cell of the leech Glossiphonia complanata. The two distinct types of cytoplasm seen with the light microscope in the adipose cell of the leech Glossiphonia complanata have been identified in the electron microscope image of this cell. One of these, the basophil cytoplasm, contains many well oriented, paired membranes which are much more clearly evident when calcium ions are added to the fixative. The membranes sometimes appear as concentric arrays of lamellae and are thought to represent sections through a phospholipide-containing body. The paired membranes and the concentric lamellae have granules attached to them and resemble in size and structure the membranes of the endoplasmic reticulum encountered in many mammalian cells. Small dense cytoplasmic particles are present throughout the cell; they may be ferritin molecules, derived from the breakdown of haemoglobin taken in as food. On the basis of a previous histochemical study and the present electron microscope investigation, it is suggested that these paired membranes are similar to the organized type of mammalian ER and the results seem to confirm the belief that these membranes are composed of layers of phospholipoprotein together with attached particles of ribonucleoprotein.


A cytochemical study of the sulfhydryl groups of sea urchin eggs during the first cleavage. In the eggs of four species of echinoderms, Mespilia globulus, Pseudocentrotus depressus, Hemicentrotus pulcherrimus and Clypeaster japonicus, changes in the distribution of protein-bound SH groups from fertilization to the 2 cell stage have been studied cytochemically by use of a mercaptide-forming azo dye. In the eggs of these species, the color intensity in the cytoplasm increased upon fertilization. The astral centers and spindle during mitosis were stained deeply. When the aster formation was suppressed by ether, hyaline spots appeared in the egg cytoplasm instead of well formed astral centers and these spots were stained by the SH-specific dye. Upon recovery of such eggs in pure sea water, and when cleavage ensued, such spots disappeared and two new astral centers were reorganized. The SH-protein occurring in the centrosphere is considered to be the precursor material for the asters and spindle, and this material is apparently derived from the cytoplasm.


An electron microscope study of smooth muscles in pregnant uterus of the rabbit. In the smooth muscle of the rabbit uterus one type of myofilament can be found; this is about 50 A thick. In the sarcoplasmic reticulum there are smooth walled vesicles and many vesicles with particles attached. It is suggested that these particles may correspond to the ribonucleoprotein-containing particles of Palade and Siekevitz. The diameter of the particles is 250 A. There are also unattached particles some of which may be glycogen. The membranes of the muscle cells and the connective tissue lying between them are described.


Spermatogenesis in animals as revealed by electron microscopy. VI. Researches on the spermatozoon-dimorphism in a pond snail, Cipango-paludina malleata. This paper reports an electron microscope study of typical and atypical spermatogenesis in the pond snail, Cipangopaludina malteata. In the typical spermatid the nucleus undergoes profound changes as development proceeds, affecting both its form and internal fine structure. A large number of roughly parallel, dense filaments, arranged along the long axis of the nucleus, fuse with each other to form in the end the homogeneous helical body characteristic of the head of the adult spermatozoa. The nebenkern is apparently mitochondrial in nature and, in its early development, is similar to that of insects except that it appears as a double structure from the beginning. As differentiation proceeds, the mitochondria lose their membranes, and the residual, now denuded cristae, reorganize to give a parallel radial arrangement. In the last stages of development, the nebenkern derivations become applied to the sheath of the middle piece in a compact helical fashion. In the development of the atypical spermatozoa, the nucleus fails to differentiate and simply shrinks in volume until only a remnant, devoid of DNA, is left. The cytoplasm shows numerous vesicles containing small Feulgen-positive bodies, 80 to 130 mmicro in diameter. These vesicles plus contents increase in number as spermatogenesis proceeds. The "head" structure of the atypical spermatozoa consists of a bundle (7 to 17) of tail flagella, each with a centriole at its anterior end. The end-piece of the atypical form appears brush-like and is made up of the free ends of the several flagella.


The relation between the axial complex of meiotic prophase chromosomes and chromosome pairing in a salamander (Plethodon cinereus). An investigation of the structure of meiotic chromosomes from primary spermatocytes of two salamanders, Plethodon cinereus and Desmognathus fusca, has been made using correlated light and electron microscopy. Feulgen squashes were compared with stained sections and these related to adjacent thin sections in the electron microscope. A transition from the familiar cytological preparation to the electron image was thus effected. A linear complex consisting of three parallel strands has been observed with the electron microscope, passing along the central axis of primary spermatocyte chromosomes. The complex is similar to that found in comparable chromosomes from at least a dozen animal species. The structure in Plethodon is described in detail. Synapsis has been positively identified as the stage of meiotic prophase at which the complex occurs. Thus the complex is a part of bivalent chromosomes. It has not been seen in other stages or other divisions and is thus thought to be exclusively of synaptic occurrence. The term synaptinemal complex is suggested for the entire structure. By virtue of the material condensed around it, the complex is also seen in the light microscope where it appears as a fine, densely Feulgen-positive central core along the chromosome. The complex is thus closely associated with DNA, if not at least in part, composed of it. In the stages studied, homologous chromosomes are not always completely paired. The lateral elements of the complex separate and follow the single chromosome axes at these points. The central element disappears and thus may be a phenomenon of pairing. It is concluded that the lateral elements of the synaptinemal complex may more correctly be a "core" of the single meiotic prophase chromosome, possibly being concerned with its linear organization.


Morphological and chemical studies of the spores and parasporal bodies of Bacillus laterosporus. Spores of Bacillus laterosporus were studied to determine the chemical and morphological nature of their basophilic canoe-shaped parasporal bodies. An unusually high phosphorus content of these spores compared to other Bacillus species appeared to be associated with the parasporal body. Preparations of these "canoes" still attached to the spore coats were indeed high in phosphorus, but also in nitrogen. They were free of lipide-soluble and nucleic acid phosphorus and stained for protein. Some 50 per cent of the total nitrogen, but only 6 to 10 per cent of the total P were liberated by extraction with alkali-thioglycollate (pH 11.5) or alkali alone (pH 12.2-12.5). Proteinaceous material was recovered from these alkaline extracts and electron microscopy indicated that there had been a marked loss of "canoe" substance. Extraction with acid, removed some 80 per cent of the phosphorus associated with the "canoes" as orthophosphate. Chromatographic analyses for amino acids indicated some 14 ninhydrin-positive spots in the canoe-coat preparations whereas the whole spores contained at least 16.


Electron microscope observations on the endoplasmic reticulum in the human fetal adrenal.


Cellular mechanism of myelination in the central nervous system. A study of myelination with electron microscopy has been carried out on the spinal cord of young rats and cats. In longitudinal and transverse sections the intimate relationship of the growing axons with the oligodendrocytes was observed. Early naked axons appear to be embedded within the cytoplasm and processes of the oligodendrocytes from which they are limited only by the intimately apposed membranes of both elements (axon-oligocytic membrane). In a transverse section several axons are observed to be in a single oligodendrocyte. The process of myelination consists in the laying down, within the cytoplasm of the oligodendrocyte and around the axon, of concentric membranous myelin layers. The first of these layers is deposited at a certain distance (200 to 600 A or more) from the axon-oligocytic membrane. This and all the other subsequently formed membranes have higher electron density and are apparently formed by the coalescence and fusion of vesicles (of 200 to 800 A) and membranes found in large amounts within the cytoplasm of the oligodendrocytes. At an early stage the myelin layers may be discontinuous and some vesicular material may even be trapped among them or between the myelin proper and the axon-oligocytic membrane. Then, when the 8th to 10th layer is deposited, the complete coalescence and alignment of the lamellae leads to the characteristic orderly multilayered organization of the myelin sheath. Myelination in the central nervous system appears to be a process of membrane synthesis within the cytoplasm of the oligodendrocyte and not a result of the wrapping of the plasma membranes as postulated in Geren's hypothesis for the peripheral nerve fibers. The possible participation of Schwann cell cytoplasm in peripheral myelination is now being investigated.


On the nature of the deoxyribonucleic acid-methyl green reaction.


Uptake of adenine-8-C14 and orotic-6-C14 acid into nuclear DNA of non-dividing cells in the adult feline neuraxis.


Mitochondrial changes in the adrenocortex of normal hamsters.


Reversibility of pre-gangrene in the severely ischaemic limb.


Selected aspects of acute and chronic gouty arthritis; an internist's interpretation of an orthopaedist's experiences with gout and gouty arthritis.


Use of cutis as an interposing membrane in arthroplasty of the knee.


Gastrocnemius recession; five-year report of cases.


Management of brachial-plexus injuries (traction type).