The stimulatory action of acetylcholine on isolated rabbit atria. Quinidine (2.5 to 5x10(-6) g./ml.) decreased the maximum rate of depolarization of the action potentials (AP) of both isolated rabbit atrial and ventricular fibres recorded with an intracellular microelectrode and finally abolished electrical excitability and spontaneous rhythmicity. Acetylcholine (ACh) 10(-6) restored these properties in the atrium (but not ventricle) without changing the membrane resting potential (MRP). Adrenaline 10(-6) to 10(-4) at the same time was without effect. The maximum rate of depolarization of an AP in response to an extra shock interposed between the 8th and 9th driving stimuli was increased by ACh 10(-6) in atria which had received quinidine to a greater extent than that of the normal AP. It is suggested that ACh restarted atria arrested by quinidine by an action on the sodium "carrying system" (excitatory mechanism) and this was not the result of an increase in MRP. An hypothesis is put forward to explain the stimulatory and inhibitory effects of ACh on rabbit atria.


Pharmacological properties of betabeta-di-methyl-acryloylcholine and some other beta-substituted acryloylcholines. The mammalian pharmacology of a new naturally occurring ester of choline, betabeta-dimethylacryloylcholine (DMAC), has been studied, mainly in the cat, together with that of two synthetic beta-substituted acryloylcholines, crotonoylcholine and pent-2-enoylcholine. Comparisons have been made with the reduced form of DMAC, isovalerylcholine, with another naturally ocurring beta-substituted acryloylcholine, murexine (urocanoylcholine), and with suxamethonium. DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine. It is also a powerful respiratory stimulant. The other unsaturated esters behaved similarly but were less potent.


Absence of renal action of pure intermediate lobe hormone. The action of melanophore expanding hormone of the intermediate lobe of the pituitary (MSH) on the urinary excretion of water, Na, K and Cl was studied in the conscious dog both during water diuresis and in the non-diuretic state. Doses of up to 2.3 IU MSH did not influence renal function. MSH did not modify the renal actions of vasopressin or oxytocin. The antidiuretic action of a massive dose of MSH was attributed to contamination by vasopressin.


Action of diethylcarbamazine in vitro on infective larvae of Wuchereria bancrofti. Infective larvae of Wuchereia bancrofti were obtained from laboratory infected Culex fatigans and maintained in serum containing diethylcarbamazine. There was no difference in the survival time of these larvae and larvae maintained in control serum without diethylcarbamazine. In one of the three experiments reported the survival time of the larvae was much longer than in the other two experiments. It is suggested that this may have been due to the presence of filarial antibodies which killed the larvae in two of the sera used. In the serum which did not contain antibodies, the larvae survived very much longer.


The effect of substance P on the peristaltic reflex of the isolated guinea-pig ileum. The introduction of substance P into the lumen of the isolated guinea-pig ileum caused an increase in the number and amplitude of the peristaltic waves. In preparations in which the peristaltic reflex was abolished, by fatigue, by external or internal application of 5-hydroxytryptamine, or by lowering the temperature of the bath, the introduction of substance P into the lumen of the intestine restored peristalsis. This effect of substance P was absent in preparations in which the mucous membrane was removed. Hexamethonium abolished the effect of substance P on peristalsis. It is concluded that substance P acts on the afferent nervous elements of the peristaltic reflex arc, possibly on the sensory receptors.


A method of assaying the anti-tetanus potency of drugs on experimental local tetanus in the rabbit. Local tetanus was induced in rabbits by the intramuscular injection of tetanus toxin. The relative potency of drugs which abolished the muscle spasm was determined using quantitative electromyography and the accuracy of the method tested with mephenesin and thiopentone. It is suggested that the method is suitable for screening new drugs for clinical use.


The chromatographic behaviour of wasp venom kinin, kallidin and bradykinin. Wasp venom kinin which has hitherto appeared to be homogeneous can be resolved by ionexchange chromatography into a single major and two minor components. These are indistinguishable by their action on smooth muscle and by their rapid inactivation by chymotrypsin. All three components of wasp kinin are chromatographically different from kallidin or bradykinin. The close similarity of the latter compounds is confirmed by their identical behaviour on an ion-exchange resin.


The activity of a variety of chemical compounds against experimental tetanus. A range of chemical compounds, mostly with central nervous system depressant activity, have been tested against experimental tetanus in the rabbit. A number of the more potent tested, including mephenesin, betanaphthoxyethanol, barbiturates and phenothiazine derivatives, have been accurately assayed by a method of quantitative electromyography. Phenothiazine derivatives were found to be the most potent anticonvulsants and of these acetylpromazine had the greatest activity. The difficulties of direct comparison of the potency of substances from different chemical groups is discussed.


Antithyroid activity of thiohydantoins.

Antithyroid activity of thiohydantoins. The antithyroid activity of 2-thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2-Thiohydantoin and its 5-alkyl derivatives from 5-methyl to 5-sec-butyl- showed considerable antithyroid activity at a dose of 0.05 m.mole/kg. by mouth, but 5-n-hexyl-2-thiohydantoin had insignificant activity at this dose level. The presence of polar groups in the 5-substituent was associated with reduction or complete loss of activity. By the single-dose technique, 2-thiohydantoin was more potent than its 5-alkyl derivatives. The opposite result was obtained by other methods of assessment after 42 days of treatment. Some of the possible factors involved are discussed especially in relation to the difficulty of comparing results obtained by the different methods of assessment. The acute toxicity of 2-thiohydantoin and of its 5-methyl and 5-ethyl derivatives is reported. No toxic effects were found after daily administration of several 2-thiohydantoins at a dose of 50 mg./kg. for 6 weeks.


Pharmacological properties of pempidine (1:2:2:6:6-pentamethylpiperidine), a new ganglion-blocking compound. Pempidine (1:2:2:6:6-pentamethylpiperidine) is a long-acting ganglion-blocking compound which is effective by mouth. By intravenous injection it has a similar potency to hexamethonium on the preganglionically stimulated nictitating membrane of the cat. The compound blocks the effects of intravenous nicotine and of peripheral vagal stimulation on the blood pressure; it also causes dilatation of the pupil after removal of the sympathetic innervation. On the guinea-pig ileum, the predominant effect of the compound is to inhibit nicotine contractions. Pempidine is well absorbed from the gastro-intestinal tract as judged by (a) the low ratio (6.9) of oral to intravenous toxicities, (b) the rapid development of mydriasis in mice after oral administration of small doses, and (c) the rapid onset of hypotension when the compound is injected directly into the duodenum of anaesthetized cats. Other actions include neuromuscular paralysis of curare-like type when large doses of the compound are injected intravenously and central effects such as tremors which occur with near toxic doses. In cats with a low blood pressure, large intravenous doses have a slight pressor action.


The relative hazards of strontium 90 and radium 226.


Some radiological observations on the effect of morphine sulphate on the gastro-intestinal tract in man.


Cerebral angiographic contrast media; a comparison of hypaque 45% and urografin 60% and an assessment of the relative clinical toxicity of urografin 60%, hypaque 45%, diaginol 25% and diodone 35% in carotid arteriography.


The Marfan syndrome, with special reference to congenital enlargement of the spinal canal.


Radiological demonstration of variations in the fluid content of the small intestine during dumping attacks.


The use of radioactive phosphorus for the detection of intraocular tumours.


Spectral distributions of 280 kVp x rays.


The radiological investigation of intracranial abscess.


Bronchi and bronchioli.

Bronchi and bronchioli.


The use of radioactive phosphorus in the diagnosis of pleural effusions.


The value of scalene node biopsy in intrathoracic disease.


Pneumoconiosis in grain workers, oil and flour millers.


Familial pulmonary embolism.

Familial pulmonary embolism.


Advances in the pharmacological study of cerase: a new anti-tu-berculous agent.


Plasma cell tumour of trachea.

Plasma cell tumour of trachea.


A fatal case of viomycin hypersensitivity.


The future of thoracoplasty in pulmonary tuberculosis.


Effect of adequate long-term chemotherapy on relapse in pulmonary tuberculosis.


Laryngeal palsy following spontaneous pneumothorax.


The conservative treatment of primary tuberculosis in children: a five-year follow-up.


The urological unit at the Meath Hospital, Dublin.


Some observations on urinary colloids in relation to renal calculi.


Titration of the calcium-binding capacity of urine.


Effect of renal tubular acidosis on calcium excretion.


Recurrent renal calculi and hyperparathyroidism.


Some anatomical and technical considerations of the employment of ileum in urology.


Retrocaval ureter replaced by segment of ileum.


The investigation and significance of persistent and recurrent urinary infection in children.


Treatment of urinary infections with nitrofurantoin (furadantin).


The dynamics of the renal pelvis and ureter with reference to congenital hydronephrosis.


Renal aplasia with pain.

Renal aplasia with pain.


Prostatectomy suitable for all types of bladder-neck obstruction.


Treatment of carcinoma of the bladder.

Treatment of carcinoma of the bladder.


Hunner's ulcer.

Hunner's ulcer.


The complications of urethral stricture.


Figures and fancies.

Figures and fancies.


Gummatous osteitis of the skull.

Gummatous osteitis of the skull.


Thrombosis of the posterior inferior cerebellar artery of luetic aetiology.


Lymphogranuloma venereum; a review of 61 cases.


Candida albicans urethritis; report of a case.


Studies on the effect of variation of concentration and origin of lecithin (natural and synthetic) in cardiolipin complement-fixation antigen.


Sacro-iliitis in Reiter's disease.

Sacro-iliitis in Reiter's disease.


Studies in prostatitis.

Studies in prostatitis.


Diagnosis of Trichomonas vaginalis urethritis in the male as a routine clinic procedure.


Penicillin treatment failures in male gonorrhoea.


Biosynthesis of fatty acids.

Biosynthesis of fatty acids.


Lipid metabolism: introduction.

Lipid metabolism: introduction.


Reiter's protein complement-fixation test; report of a trial in 1,000 unselected cases.


Hormonal effects in vitro on lipogenesis in mammary tissue.


Fat absorption and its disorders.

Fat absorption and its disorders.


Biosynthesis of cholesterol.

Biosynthesis of cholesterol.


The absorption and metabolism of sterols.


Removal of lipids from the blood stream.


The effect of dietary fats on the blood lipids and their relation to ischaemic heart disease.


Hormonal control of the circulating lipids.


Fats and blood coagulation.

Fats and blood coagulation.


Essential fatty acids and the skin.

Essential fatty acids and the skin.


Essential fatty acids and human disease.


Lipids and the structure of myelin.

Lipids and the structure of myelin.


Thyroid neoplasms following irradiation.


Surgical collapse during and after corticosteroid therapy.


Blood groups, haemoglobins, and thalassaemia in Turks in southern Turkey and Eti-Turks.


A blood transfusion service in Cyprus; with notes on the ABO groups of Cypriots.


The mechanism of post-parotidectomy gustatory sweating (the auriculo-temporal syndrome).


Chronic splenomegaly and its relation to hepatic pathology.


Case of infantile ulcerative colitis.

Case of infantile ulcerative colitis.


Addiction to unrestricted drugs.

Addiction to unrestricted drugs.


Carcinoma of the thyroid following irradiation.


Fatal haematemesis due to foreign body in stomach.


Intussusception in a case of penetrating abdominal injury.


BLOOD groups in Cyprus and the Near East.


FLAPPING tremor.

FLAPPING tremor.


CARCINOGENIC risk of thyroid irradiation.


VIRUS diseases in pregnancy.

VIRUS diseases in pregnancy.


MATABOLISM of lipids.

MATABOLISM of lipids.


PICKWICKIAN syndrome.

PICKWICKIAN syndrome.


Analogue computers for research on learning.


POPE PIUS XII; one of his last talks to doctors.


Pharmacology of tranquillizing drugs.

Pharmacology of tranquillizing drugs.


J. HINTON ROBERTSON.

J. HINTON ROBERTSON.


T.H. SANDERSON-WELLS.

T.H. SANDERSON-WELLS.


Effect of small doses of alcohol on a skill resembling driving.


Simple clinical hearing-tests for very young or mentally retarded children.


Present place in obstetrics for foetal phonocardiography and electrocardiography with the newer techniques of foetal electroencephalography and movement-recording.


Adult chronic bronchitis: continuous antibiotic therapy.


Carbon dioxide poisoning: report of eight cases, with two deaths.


Trial of dequalinium for skin infections.


Size of the adrenals in Jamaicans.

Size of the adrenals in Jamaicans.


Conversion testing of schoolchildren after B. C. G. vaccination.


Tuberculous meningitis following B. C. G. vaccination.


Hypoproteinaemia after partial gastrectomy corrected by gluten-free diet.


Arthropathy due to gastric carcinoma.

Arthropathy due to gastric carcinoma.


PROGNOSIS and treatment of disseminated sclerosis.


THE DEAF child.

THE DEAF child.


SEPARATION of craniopagus twins.

SEPARATION of craniopagus twins.


INTRACRANIAL neoplasms and pregnancy.

INTRACRANIAL neoplasms and pregnancy.


SEX EDUCATION for students.

SEX EDUCATION for students.


ARE MICROWAVES dangerous?

ARE MICROWAVES dangerous?


Sedatives and tranquillizers. I.

Sedatives and tranquillizers. I.


WHY SUFFER from rheumatism? A review of 157 cures submitted to the research subcommittee of the Empire Rheumatism Council.


A pressure injector for use in angiocardiography and aortography.


JANE H. TURNBULL.

JANE H. TURNBULL.


G. S. SEED.

G. S. SEED.


J. K. J. HAWORTH.

J. K. J. HAWORTH.


The physiological activity of d-thyroxine.


Occult blood in faeces after administration of aspirin.


The immediate uptake of radioactive iodine as a test of thyroid function.


Use of iproniazid in ischaemic angina pectoris.


Jaundice associated with administration of iproniazid; report of two cases.


Toxic effects of iproniazid in a patient with angina.


Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium; a report on a controlled therapeutic trial.


Ankylosing spondylitis.

Ankylosing spondylitis.


Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium; a controlled trial employing restricted sequential analysis.


Value of azacyclonol on chronic schizophrenic patients; preliminary observations.


An African's mental outlook in Britain.

An African's mental outlook in Britain.


Congenital reduplication of ileo-caecal valve presenting as an acute intussusception.


Allergic Encephalomyelitis.

Allergic Encephalomyelitis.


UNMARRIED parenthood.

UNMARRIED parenthood.


GOITROUS hypothyroidism.

GOITROUS hypothyroidism.


BLOOD groups of mummies.

BLOOD groups of mummies.


IMMUNIZATION against diphtheria.

IMMUNIZATION against diphtheria.


B12 ASSAYS in megaloblastic anaemia.

B12 ASSAYS in megaloblastic anaemia.


Sedatives and tranquillizers. II.

Sedatives and tranquillizers. II.


The pharmaceutical house and the doctor.


TOOLS of biological research; symposium at Guy's Hospital.


J. A. Gunn.

J. A. Gunn.


D. B. McGRIGOR

D. B. McGRIGOR


WILLIAM DAVIES.

WILLIAM DAVIES.


Medicine's challenge to the educator.

Medicine's challenge to the educator.


Serum glutamic oxalacetic transaminase in acute myocardial infarction.


Serum transaminase: its clinical use in diagnosis and prognosis.


Scurvy following bilateral adrenalectomy; report ot two cases.


Surgery of atrial septal defects.

Surgery of atrial septal defects.


Public health aspect of tuberculosis in domestic animals.


Clinical comparison of methyprylone and quinalbarbitone as hypnotics; sequential analysis used.


Indolic compounds in the urine of schizophrenics.


Rationale of antihistaminic therapy in thermal injury; an experimental evaluation in the guinea-pig.


Hypothermic myxoedema coma; three case reports.


Bilateral polycystic disease of kidney complicated by intestinal obstruction.


TRANSFUSION treatment of radiation disease.


DRUGS and liver disease.

DRUGS and liver disease.


SERUM transaminase in myocardial infarction.


OPEN DOORS.

OPEN DOORS.


COST OF hospital departments.

COST OF hospital departments.


HEALTH in industry.

HEALTH in industry.


Drugs in treatment of epilepsy.

Drugs in treatment of epilepsy.


Ah, my old friend Dr. Harvey.

Ah, my old friend Dr. Harvey.


JOHN MEGAW.

JOHN MEGAW.


Late results of operations for Fallot's tetralogy.


Vaccination against poliomyelitis with live virus vaccines. 4. A review of the present position.


Vaccination against poliomyelitis with live virus vaccines. 5. Neutralizing antibody levels one year after vaccination.


Rectal temperature in the newborn after birth asphyxia.


Combined gastric and duodenal ulceration; a survey of 157 cases.


A small-scale trial of type III attenuated living poliovirus vaccine.


Treatment of rheumatoid arthritis with chloroquine.


Uncontrollable post-operative haemorrhage after incompatible blood transfusion.


Second bacteriological study from a maternity hospital.


The isolation of Trypanosoma rhodesiense from a bushbuck.


Acute haemolytic anaemia in a case of infantile gastro-enteritis treated with oxytetracycline.


ENVIRONMENT and blood pressure.

ENVIRONMENT and blood pressure.


COMPENSATION for injury.

COMPENSATION for injury.


LIVE POLIOMELITIS vaccine.

LIVE POLIOMELITIS vaccine.


DETECTION of ovulation.

DETECTION of ovulation.


Drug treatment of parkinsonism.

Drug treatment of parkinsonism.


Early disturbance of behaviour in relation to mental defect.


ARTHUR MILLER.

ARTHUR MILLER.


Social work in general practice.

Social work in general practice.


The centenary of the General Medical Council.


KATHERINE J. S. CLARK.

KATHERINE J. S. CLARK.


The influence of the General Medical Council on education.


Elizabeth Blackwell and the Medical Register from 1858.


The disclplinary committee and the courts.


The history and development of the British Pharmacopoeia.


Endocrine control of blood sugar, lipaemia, and ketonaemia in diabetic baboons.


Treatment of nocturnal enuresis by the electric alarm.


Renal function in scleroderma.

Renal function in scleroderma.


Onset enuresis.

Onset enuresis.


Serum containing three Rh autohaemagglutinins.


Visual disturbances associated with trivalent antimony salts; a report of two cases.


ONE HUNDRED years of the G. M. C.

ONE HUNDRED years of the G. M. C.


A psychological analysis of the Munchausen syndrome: request for information.


Acute barbitone and bromide poisoning with unusual features.


OPERATIONS for Fallot's tetralogy.

OPERATIONS for Fallot's tetralogy.


RENAL response to exercise.

RENAL response to exercise.


GRADING atheroma.

GRADING atheroma.


Treatment of chronic heart failure.

Treatment of chronic heart failure.


The effectiveness of the tissue committee at the Missouri Baptist Hospital.


Hyper-immunization of man.

Hyper-immunization of man.


Arthur Wilburn Allen; 1887-1958.

Arthur Wilburn Allen; 1887-1958.


A simplified explanation of the theory of indicator-dilution for measurement of fluid flow and volume and other distributive phenomena.


The effect of thyroid hormones and temperature on the kinetics of contraction and relaxation of ventricular heart muscle.


Changes in reflex patterns following spinal cord hemisection in cats.


The medical center library: a symposium; the concept of the medical center.


Stretch reflexes in patients with spinal cord lesions.


The medical center library: a synposium; dental research in a medical center library.


Oxygen tension and acid-base adjustment in cardiac failure.


The medical center library: a symposium; the administrative problem of a medical center library.


The medical center libray: a symposium; planning for staff and services.


The medical center library: a symposium; the new medical center library.


A summary of Lavoisier's proposals for training in science and medicine.


John Stewart Rodman; 1883-1958.

John Stewart Rodman; 1883-1958.


Prescribing hospitalization.

Prescribing hospitalization.


Resurrection and legislation or body-snatching in relation to the Anatomy Act in the Province of Quebec.


The fear of death.

The fear of death.


An 18th century scientist's observation of his own aphasia.


Projective tests in the evaluation of the tranquilizing drugs.


The genesis of an eponym.

The genesis of an eponym.


The Fielding H. Garrison list of medical and scientific periodicals of the 17th and 18th centuries; addenda et corrigenda.


Therapeutic failures in pulmonary tuberculosis.


Some implications of tuberculosis to-day; the influence of clinical treatment.


The connective tissues in medicine and surgery.


Rapid detection of drug resistant tubercle bacilli by slide cultures of sputum.


Human trials of tuberculosis prophylaxis.


Prevention of habitual spontaneous abortion with early prenatal care.


Rheumatic fever; a review of the literature.


John Wakefield Francis, 1789-1861; the Academy's second president.


The carditis and aortitis of ankylosing spondylitis.


Salpingolithiasis simulating acute appendicitis: report of a case.


Obstetrical case report.

Obstetrical case report.


Triquin in the treatment of discoid lupus erythematosus and light sensitive eruptions.


Radioactive fallout.

Radioactive fallout.


A survey of British work on radioactive fallout.


The world-wide deposition of long-lived fission products from nuclear test explosions.


Entry of radioactive fallout into the biosphere and man.


World-wide distribution of strontium-90 and its uptake in man.


[The problem of the biological activity of weak doses of ionizing radiations].


Radiation dose to staff in diagnostic x-ray departments.


Somatic effects of low-intensity radiation at different levels of biological organization.


Epidemiological studies of radiation leukaemogenesis in man, with particular reference to the possible nature of the dose-response relationship.


[Presence of a gene of resistance to dieldrin in Anopheles gambiae Giles, in the Lower Ivory Coast (French East Africa)].


Malaria parasite rates in Southern Rhodesia: May-September 1956. The author reports on malaria parasite rates found in the indigenous population of Southern Rhodesia after seven years of insecticide spraying. Although there is little or no overt malaria in sprayed areas, larvae of Anopheles gambiae are still found in certain foci. It is thought possible that the parasite rate is now so low that for practical purposes a break in transmission has been achieved, but the author points out that a dangerous potential source of infection exists in immigrant labour from other territories. Immigrants are now being treated on entry with up to 450 mg of amodiaquine and 45 mg of primaquine.


The eradication of Simulium neavei from Kenya. S. neavei, the vector of onchocerciasis, has been virtually eradicated from Kenya by larviciding measures in which DDT was used. Only a very small area remains infested and this is in the course of being treated by the Uganda medical authorities as it is part of a much larger focus occurring in that country. An account is given of the various surveys which have been carried out during the last ten years in Nyanza Province, involving 15 000 square miles (about 40 000 km(2)), and survey techniques are described. An account is given of the eradication measures carried out in North and South Nyanza, and techniques in connexion with dosing and checking operations are described. Costs for both surveys and eradication schemes are given, and minimum requirements for transport are indicated.


Chloroquine or pyrimethamine in salt as a supressive against sporozoite-induced vivax malaria (Chesson strain). The authors present the results of a study carried out to determine the efficacy of chloroquine- and pyrimethamine-salt mixtures as a suppressive against sporozoite-induced vivax malaria (Chesson strain). The test subjects used in this study were volunteers of military age in the US Penitentiary at Atlanta, Ga. The subjects chosen were all in good physical condition and had no previous history of malaria.Both drug-salt mixtures were entirely acceptable to the volunteers, were indistinguishable in taste and appearance from ordinary salt, and remained stable under the conditions of food preparation. The weekly dosage of the drugs (300 mg of chloroquine base or 25 mg of pyrimethamine per 50 g of salt) had in each case been adjusted to the average salt consumption. Suppression of malaria was found to be complete throughout the salt-drug regimen and for 28-43 days thereafter, even though the subjects were exposed to repeated heavy doses of sporozoites. In contrast, the control subjects, exposed to the same infective doses, all exhibited parasitaemia 13-15 days after exposure.The procedures for preparing the drug-salt mixtures are described in detail and a simple method for determining the salt consumption by measurement of the urinary chloride excretion is outlined.


Studies with dried and glycerinated smallpox vaccines of full and diminished potencies. In a further vaccination and laboratory study with two dried smallpox vaccines (designated "P" and "Q") and one glycerinated vaccine, the potency of samples of each vaccine was deliberately lowered by exposure to heat. Groups of volunteers were vaccinated with the fully potent vaccines and with those of reduced potency. All subjects who developed a vesicular response were challenged one year later by revaccination with a potent vaccine, and the results obtained in the different groups were compared. No significant variation could be detected in the response of the different groups to the challenge vaccination. These findings indicate that if vesiculation is obtained with a vaccine, even though potency has been reduced to a point where it produces less than 50% successful primary vaccinations, satisfactory protection will result one year later. It also appears that successful vaccination with a dried vaccine confers as good immunity as that obtained from glycerinated lymph. Vaccines with a pock count of 10(6) infective units per millilitre will produce about 40% successes in primary vaccination.


The present status of laboratory research in trachoma. The present status of laboratory research in trachoma is summarized. The principal factors which have retarded research on this disease have been the lack of a suitable experimental animal and the failure of tissue-culture methods to provide serial cultures of the virus. Some avenues of investigation for the future are suggested.


Laboratory diagnosis of streptococcal infections.


Immunization studies on human volunteers with ether-killer Brucella abortus: preliminary report.


A recommended method for the preparation of monospecific Brucella sera. A method is described in detail for the preparation of monospecific sera for typing brucella cultures. The importance of using entirely smooth cultures throughout the procedure is emphasized. A single intravenous injection of living brucellae in rabbits caused an active infection and the early appearance of high-titre antibodies. Sera obtained five to seven days after inoculation contained a higher proportion of specific antibodies than serum obtained ten days after inoculation. Trial absorptions of each serum sample were performed to determine the relative content of homologous and heterologous antibodies, so that the optimum proportions of absorbing cells to serum could be employed for the final absorption. In this manner sera were obtained which at a 1/160 dilution agglutinated the homologous antigen and at a 1/10 dilution did not agglutinate the heterologous antigen.Monospecific sera were used in typing 180 brucella strains isolated in Great Britain and other countries, and over 3000 cultures recovered from experimental infections. With the exception of two strains of Br. melitensis, all cultures were agglutinated to titre with only one of the monospecific sera.


The use of gel diffusion precipitin plates in the study of Brucella. The use of gel diffusion precipitin plates in the study of brucella is described.Cultures of Brucella melitensis yielded a diffusible precipitin antigen which produced lines with sera of rabbits, goats, and cattle that had been infected with either Br. abortus or Br. melitensis. The precipitin lines varied in number from one to three.A diffusible precipitin antigen could not be prepared from Br. abortus and Br. suis cultures by the methods which were effective in producing such an antigen from Br. melitensis.No precipitin reactions occurred with sera from cattle in brucella-free herds which had been inoculated with Strain 19 vaccine, although some of these sera were positive to the agglutination test.


A preliminary report on a selective medium for the culture of Brucella, including fastidious types.


Comparative efficacy of trypticase-soy and veal infusion broths for isolating Brucella abortus from the blood of cattle.


Staining of filarial larvae in insects before dissection.


Studies on insecticide-resistant anophelines. I. Chromosome arrangements in a dieldrin-selected strain of Anopheles atroparvus. The authors present the results of a cytological examination, carried out by the technique developed by Frizzi, of the larvae of a normally susceptible and a dieldrin-selected strain of Anopheles atroparvus, both laboratory-reared. A very high percentage (77.4) of heterozygous inversions was observed in the larvae of the 28th generation of the dieldrin-resistant strain, whereas only 20.8% occurred in the normally susceptible strain, in which the standard chromosomal arrangement predominated (74.2%). These results are similar to those obtained recently by other workers in the case of larvae of the 12th generation of a DDT-selected strain of A. atroparvus (74.8% heterozygous inversions observed).


Vector snail control in Qalyub, Egypt.

Vector snail control in Qalyub, Egypt. The author describes a pilot study in vector snail control carried out in 1953-54 by the Bilharziasis Control Project in Qalyub, Egypt.After giving a brief description of the site chosen for the Project-an area of some 5000 acres (2000 hectares) under perennial irrigation-he presents a detailed account of the various snail surveys of the irrigation canals and drains and of the molluscicidal treatment of infested channels.He points out that despite the thoroughness of the surveying and treatment the snails were not completely eliminated from the area and stresses that the high cost of the molluscicide used (copper sulfate) would prohibit its widespread and continual use. He considers, however, that pending the perfection of such long-term bilharziasis control measures as improved sanitation, better treatment facilities, and health education of the public, snail control is of the first importance and determined efforts should be made to find more efficient and cheaper methods of effecting it.


Biology and control of Taeniorhynchus (Mansonioides) uniformis Theobald, the chief vector of rural filariasis in Ceylon. Residual spraying of DDT for the control of Taeniorhynchus (Mansonioides) uniformis, the mosquito vector of rural filariasis in Ceylon, was carried out in Induruwa, a village on the west coast of the island. The results showed that the insecticide retained its effectiveness for a period of 4-6 months.During the course of this investigation, various observations were made on the behaviour of T. (M.) uniformis. Its host plants, day-time resting-places, feeding habits, and response to light-particularly moonlight-were recorded. An increase in T. (M.) uniformis prevalence was observed to coincide with the onset of the north-east and south-west monsoons, when the paddy-fields are inundated and become overgrown with Isachne australis, the most common aquatic plant in the area and a favourite breeding-place of this mosquito species.


Mortality from cardiovascular diseases in various countries, with special reference to atherosclerotic heart disease: a preliminary analysis. Data on cardiovascular mortality, by sex and age, in selected countries were analysed for the purpose of demonstrating geographical variations.In accordance with the system adopted in the International Statistical Classification of Diseases, Injuries, and Causes of Death, causes were divided into four groups: (1) arteriosclerotic and degenerative heart disease; (2) vascular lesions affecting the central nervous system; (3) other diseases of the heart; and (4) certain other diseases of the circulatory system.The discrepancies noted point to the need for a thorough investigation of the underlying causes of cardiovascular deaths in order to promote comparability of recording and classification.


Involvement of the eye in protein malnutrition. An extensive review of the literature on protein malnutrition, with special reference to the frequency of involvement of the eyes, has been made by the author. Consideration of accounts from all parts of the world and in many different languages, including early as well as more recent descriptions of the syndrome, indicates that this important complication has not received sufficient attention hitherto. The evidence available suggests that it is nearly always an accompanying deficiency of vitamin A that is responsible. Less commonly reported-and producing less severe effects-is deficiency of the B-complex vitamins, and there is no clear evidence to date that protein deficiency itself damages the eyes in these cases.The ways in which protein lack might interfere with various aspects of vitamin-A metabolism are discussed, but it is pointed out that their actual significance in human disease is not yet known. A low dietary intake of vitamin A is regarded by the author as being the prime factor in the causation of eye complications, and attention is drawn to the necessity to correct this as part of any prophylactic or therapeutic programme aimed primarily at combating protein malnutrition.


The psychiatric hospital and its place in a mental health service. Modern methods of treatment of mental disease enable the average length of stay in hospital to be drastically reduced. The former overcrowding is therefore disappearing; in fact, it should be possible to contemplate a reduction in the size of the hospitals, particularly if new admissions are kept to a minimum by the provision of efficient out-patient clinics and of adequate geriatric and domiciliary nursing services. Taking recent trends in England and Wales as his starting point, the author outlines ways in which a modern mental health service might be built up around existing facilities under a variety of conditions. He advocates that, as far as possible, the treatment of mental disease should be integrated into general medicine, and emphasises the need for close co-operation between psychiatrists, family doctors, and the staff of general hospitals.


Third international standard for posterior pituitary; re-named third international standard for oxytocic, vasopressor and antidiuretic substances in 1956. In October 1955, stocks of the Second International Standard for Posterior Pituitary were running low and the Department of Biological Standards of the National Institute for Medical Research, London, was asked to proceed with the arrangements for an international collaborative assay of material for the Third Standard. A single 142-g batch of posterior-pituitary-lobe powder was obtained and distributed in ampoules, in approximately 30-mg quantities. Samples were sent to 19 laboratories in 10 countries. In all, 185 assays were carried out, 122 for oxytocic activity, 53 for vasopressor activity and 10 for antidiuretic activity.On the basis of the results, which were analysed statistically at the National Institute for Medical Research, it was agreed that the potency of the Third Standard (re-named International Standard for Oxytocic, Vasopressor and Antidiuretic Substances in 1956, in view of the recent synthesis of oxytocin and vasopressin) should be expressed as 2.0 International Units per milligram. The International Unit therefore remains unchanged as 0.5 mg of the dry powder.


Reference toxins for antivenin standardization. Potency determinations in mice of venom samples from snakes of the species Bothrops jararaca, which had been caught in an area of less than 10 000 km(2), gave the following principal results:(1) Various methods of drying-i.e., closed and continuous vacuum-drying at 5 degrees and 37 degrees C and freeze-drying (lyophilization)-had no different effect on the potency of venoms.(2) Venom samples which display no differences in the final results of intravenous assay may be distinguishable if the observation time is limited to one or two hours.(3) Venom samples obtained from snakes caught no more than about 50 km apart may be of different potencies.(4) Different titres may be obtained for an antivenin, if different samples of venom from the same snake species are employed as reference preparations in the assay.From physiological experiments on dogs and rabbits, in conjunction with observations made in tests on mice, it is evident that B. jararaca venom causes death in circulatory collapse through a mechanism which is as yet unknown. Two physiologically (and probably immunologically) distinct hypotensory factors seem to be present in this venom.The conclusions drawn from the investigation is that consistent and reproducible reference preparations of snake venoms for antivenin assay can probably be obtained only from snakes that are bred and kept in captivity under constant environmental conditions.


Studies on Schistosoma japonicum infection in the Philippines. III. Preliminary control experiments. Among the measures used in attempts to control the snail host of S. japonicum in Leyte Province, Philippines, where the terrain is unsuited to the application of molluscicides, have been removal of vegetation in and around infested streams, drainage of water-logged areas, filling low-lying areas with earth or flooding them, and digging fishponds in sluggish streams. Each of these measures is described in detail.Experiments carried out in rice-fields, which harbour great numbers of snails, have shown that improvements in rice-growing methods will not only markedly reduce the snail population but also double the rice yield.A campaign to promote the use of pit latrines encountered the serious difficulty that such latrines were not acceptable to the people. However, there is evidence that use of pit latrines does bring about a reduction in snail infection rates.No single control measure is recommended for all snail habitats, the choice of method depending on local circumstances; in many areas a combination of methods proved advantageous. It is felt that mass treatment of infected persons would not be fully effective until transmission is more thoroughly under control.


TOXICITY of pesticides to man and animals, 1957.


[Technical details in orthoptic & surgical treatment of strabismus].


[Recurrence of interstitial keratitis related to cortisone therapy; 145 cases collected from 1926 & 24 cases collected from 1950 to 1956].


Long term isoniacid in the management of pulmonary tuberculosis.


The backgrounds of social medicine; the etiology and epidemiology of health and disease.


The trachoma problem in Burma.

The trachoma problem in Burma.


Fractures & femur.

Fractures & femur.


Intramedullary nailing procedure for fractures of the femoral shaft.


Depressed fracture of the vault of cranium in adults.


OBITUARY: U Tin.

OBITUARY: U Tin.


Fungus disease in Northern California.

Fungus disease in Northern California. A systematic search for disease caused by fungi was made in a group of patients from northern California. Superficial mycotic infection was diagnosed frequently. Systemic fungus infection was found in approximately 0.6 per cent of an unselected group observed at Stanford University clinics-coccidioidomycosis or actinomycosis in almost all cases.Clinically unsuspected fungus infection was rare. Various species of Candida were frequently recovered, particularly from debilitated patients who had received antimicrobial therapy. Only rarely could these organisms be conclusively demonstrated to have caused serious disease.


THE CANCER problem in Burma.

THE CANCER problem in Burma.


Problems in ventilation in the immediate postoperative period. In the present day practice of surgical anesthesia, drugs and techniques are used which require or lead to cessation of voluntary respiration by the patient. Respiration is then controlled by the anesthesiologist. At the termination of operation many patients do not breathe adequately for variable periods of time. The causes include obstruction, excessive sedation, muscle relaxants, the effect of controlled respiration itself and various miscellaneous factors. A diagnosis is made by taking into consideration the drugs and techniques which have been used and the character of the patient's respiratory efforts, if any. The cause may then be treated. In some cases antidotes are available. However, until truly adequate spontaneous respiration is observed for some time the patient must have his efforts assisted. High oxygen concentrations must not be substituted for adequate ventilation.


Electromyography; uses and limitations.

Electromyography; uses and limitations. A normal muscle at rest emits no detectable electric current, but in action, in diseases of the muscle and in denervation it emits electric impulses characteristic of these states. The impulses can be amplified and studied through the sonic and oscilloscopic patterns they create. These patterns are sufficiently different so that simple atrophy of disuse can be distinguished from the denervation that may be associated with it. Since denervation can be localized to individual muscles and thence to the nerves controlling them, electromyography serves much the same function as myelography, with comparable accuracy and with greater safety and simplicity. It aids in the diagnosis of several muscular diseases of children and adults. Because electromyographic changes due to injury do not appear until 18 to 21 days later, a study made soon after injury can either disclose or rule out preexisting lesions. Then a later study indicating denervation is objective evidence that any disability is due to the injury in question.


Plasmanate: a new plasma substitute for pediatric therapy. Plasmanate(R), a human-serum protein solution, appears to have all the attributes of an ideal plasma expander. Freedom from infection, immediate availability in a clear, stable solution and the apparent absence of antigenic properties are particularly valuable qualities. The efficacy and safety of Plasmanate was clinically demonstrated in the treatment of 125 infants and children. This solution seems especially effective in the treatment of acute shock states and for the physiologic correction of hypoproteinemia. Comparison with other plasma expanders makes Plasmanate the agent of choice in the initial treatment of shock states in pediatrics.


Importance of caloric intake during renal failure. Loss of excretory function in acute renal failure results in the retention of catabolites and fluid. In the absence of available carbohydrate, endogenous fat and protein become the main caloric sources. This results in the rapid accumulation of keto acids and nitrogenous wastes. By providing readily available non-nitrogenous calories, protein catabolism is reduced, complete oxidation of fat is obtained and energy is provided to drive potassium into the intracellular compartment. The patient should be encouraged to eat despite his apathy, fear of vomiting and characteristically paranoid mood. Tube or parenteral feeding is complicated by the need to restrict fluid. Numerous small feedings are more successful than large meals. Hard candy and alcohol are often acceptable sources of calories, fat emulsions seldom. Oral hygiene aids feeding, and tranquilizers and anticholinergics are useful. If the patient does not take food by mouth, tube feeding may be carried out. Because of the bleeding tendency so often occurring in uremia, tube feeding may be contraindicated if it causes erosion of the pharynx or esophagus. Intravenous infusion of invert sugar, glucose and alcohol may be necessary if nutrition cannot be accomplished by other means.


Effectiveness of antacids in reducing digestive disturbances in patients treated with prednisone and prednisolone. To appraise the efficiency of complemental antacid administration in preventing and reducing digestive disturbances during prolonged treatment with prednisone and prednisolone, 100 patients with active rheumatoid arthritis who were maintained on combined antacid and prednisone or prednisolone therapy for periods of one year or longer, were studied clinically and roentgenographically. Antacid therapy consisted of 300 mg. of dried aluminum hydroxide gel and 50 mg. of magnesium trisilicate taken with each 2.5 mg. dose of the steroids. Digestive symptoms, such as indigestion, heartburn, sour eructations, gnawing epigastric distress and the like, were experienced by 18 per cent of patients during treatment with prednisone or prednisolone combined with antacids. Among patients who had been maintained on the steroids without antacids beforehand, the incidence of digestive complaints was reduced from 38 per cent to 17 per cent by the addition of alkali therapy, and the severity of the distress decreased in others. Active peptic ulcers were detected roentgenographically in three of the 100 patients. In two instances the ulcers were asymptomatic and in two instances they were considered as reactivations of previously healed lesions. The incidence of active ulcers in this series was substantially lower than that reported by several investigators among patients treated with prednisone and prednisolone without the concomitant administration of alkalis. The size of dosage and individual susceptibility appeared to be important factors in the development of digestive disturbances from steroids. Results of the study indicated that the complemental use of antacids with each divided dose of steroid is highly effective in reducing the frequency and severity of digestive symptoms during prednisone and prednisolone administration. The low incidence (3 per cent) for roentgenographically demonstrable active lesions in the series suggests that the addition of acid-neutralizing agents during prolonged treatment with these steroids may afford at least partial protection against the development and reactivation of peptic ulcers.


Cancer, coronary artery disease and smoking: a preliminary report on differences in incidence between Seventh-day Adventists and others. A study was made of the incidence of certain types of disease among Seventh-day Adventists, a religious group of special interest because they refrain from smoking and drinking. Epidermoid cancer of the lung, previously shown to be related to smoking, was 10 times less common among Seventh-day Adventists than among the general population, even among those Seventh-day Adventists living in the Los Angeles area where all are exposed to smog. Similarly, cancers of the mouth, larynx, and esophagus, previously shown to be related not only to smoking but also to heavy drinking, were at least 10 times less common among Seventh-day Adventist men than among men of the general population. All other types of cancer, with the exception of cancer of the bladder and cervix, occurred among Seventh-day Adventists with the same frequency as in the general population. The latter occurred slightly less than in the general population. Myocardial infarction in Seventh-day Adventist males was less frequent and occurred at a later age than among males in the general population; while the age distribution of the disease among the Seventh-day Adventist females was similar to that of females in the general population.


The large inguinal ring: its significance in the diagnosis of inguinal hernia. A large external inguinal ring is often reported by a medical examiner as a "potential hernia." This finding may cause the subject to be denied job opportunities and may make him apprehensive about many normal activities. The author believes that unless a sac is present and is causing symptoms that necessitate surgical relief, the term hernia should not be used, regardless of how it is qualified. The ordinary intraabdominal stresses due to coughing, sneezing, etc. increase intraabdominal tension more than heavy lifting, except with loads of nearly the body's own weight. The lifetime effect of such stresses can contribute to the development of a direct hernia, but most of these cannot be eliminated.


Medico-legal aspects of traumatic epilepsy. The medico-legal problems of cranial injuries require a broad assessment of many factors, not always related to the nervous system, and a nicety of judgment in correctly evaluating the role of each factor in relation to all of them. Seizures in the period immediately after trauma are not necessarily precursors of later development of epileptic attacks. If such seizures do occur, it can be said in general, from statistical data, that the sooner they occur after injury the less the likelihood of disabling attacks later. It would seem a reasonable medical probability that if a patient has no neurological symptoms or deficit, has a normal electroencephalogram and has gone two years after injury without evidence of seizures, he will not have epilepsy. Putting a label of "post-traumatic epilepsy" on a patient, unless he is known to have had authentic seizures, may stigmatize him without warrant and lead to unjust settlement of litigation or to unreasonable compensation awards. In doubtful cases, perhaps an equitable solution of compensation for damage would be to award an insurance policy providing suitable payments if disabling seizures should develop later as a sequel of cranial injury.


Anaphylactic death from erythromycin.

Anaphylactic death from erythromycin.


Fibrocystic disease of the pancreas and diabetes in an adult with unusual pulmonary manifestations.


Pulmonary collapse as a complication of bronchial asthma in a child.


Spontaneous pneumothorax complicating pulmonary metastasis of sarcoma.


Extensive scleral perforation with complete recovery.


The use of ataractic agents; some psychiatric implications. Physicians should understand the psychic as well as the chemical effects of ataractic drugs, especially since they are prescribed chiefly for illnesses of emotional origin. The patient may feel that he is "being put off with a pill;" on the other hand, both patient and physician may be encouraged (and thus able to work better together) because the prescription of a drug represents "doing something" about the disorder. This ability to "do something" may tempt the physician to resort too readily to relieve normal and even healthful tensions of living. If the drug has pronounced physical effects (especially side effects), the patient may resent the prescription as an aggression; this danger is great if his emotional problem stems from oral and nutritional conflicts of childhood.


Headache of extracranial origin.

Headache of extracranial origin. The cervical spine, usually regarded as a supporting structure for the head, is also an important viaduct of vessels and nerves which must function with little clearance in a congested and moving space bounded by bone. Pressure in this viaduct is an important cause of headache.The cervical foramina although apparently roomy, are constricted by cartilage, by the vertebral artery and its adnexae, and by the lateral intervertebral joints. Osteophytosis, swelling or adhesion in this constricted space almost inevitably causes painful vascular or neural disorder. In certain postures of the neck the vertebral artery is constricted or even occluded. Traction or sprain may likewise cause headache through disturbance of the vertebral arterial nerves, the posterior cervical autonomic system or the spinal accessory nerves which originate in delicate filaments from all points of the cervical spinal cord.A syndrome described by Skillern-migraine-like suboccipital and retro-orbital headache-is due to disturbance of the second cervical nerve, which communicates with the first division of the trigeminal nerve. Headache due apparently to a minor scalp contusion may really be due to irritation of a trigger area at the site of an old scalp injury.


Whiplash injuries; diagnosis and treatment. Whiplash injury may extend far beyond the neck, and may involve even the soft tissues of the pelvis. For permanent recovery, all the injuries must be evaluated and treated together. When impact from the rear snaps the head back and then forward, posterior subluxations in the cervical spine cause anterior-posterior narrowing of the intervertebral foramina, which may result in injury to the cervical nerve roots. Impact at the front, causing hyperflexion followed by hyperextension, has a similar effect although usually not as severe. Resulting symptoms may not appear until two or three weeks later, when irritative lesions have developed because of hemorrhage or swelling. Mild or progressive degenerative changes may cause no symptoms but may predispose the affected area to injury following some slight trauma. Capsular ligaments of the lateral intervertebral joints are especially liable to whiplash injury which may give rise to scars and adhesions that compress spinal nerves. Sympathetic system involvement may cause reflex and referred pain. Detailed neurologic, roentgen and electromyographic studies may be necessary for proper evaluation of injuries. Seemingly psychosomatic pain or disability is likely to have some physical basis in whiplash injuries. In 33 patients with whiplash injury, some recently injured and some chronically disabled with persistent symptoms, good results were observed following hydromassage, hot packs, joint mobilization exercises and, in a few, cervical or pelvic traction.


Noncicatrizing alopecias; with special reference to alopecia areata. Since the epochal work of Hamilton there has been general acceptance of the causal relationship of the male sex hormone, age and familial inheritance in development of male pattern baldness. Some of the medicaments used in recent years may cause a diffuse loss of scalp hair. Alopecia that accompanies disease states is probably due to generalized toxemia and disturbances in metabolism. Sometimes male pattern baldness occurs in physiologic states, as exemplified by diffuse hair loss occasionally in the postpartum period. Alopecia areata deserves a critical appraisal, since it may be evidence of underlying neuropsychotic states that need psychiatric diagnosis and treatment. The development of alopecia totalis or universalis in 50 per cent of the prepuberal cases of alopecia areata is of real significance, especially since so very few patients recover their normal scalp hair. The conclusions reached by the authors of two articles reporting on 368 cases of alopecia areata, alopecia totalis and alopecia universalis that the evidence is overwhelming against the malfunction of the endocrine glands as the cause of alopecia areata must be considered real contributions to our understanding of this condition.A few conditions simulate alopecia areata. Probably the ones which are seen most often are trichotillomania and patchy baldness caused by agents used in hair waving and straightening. Our findings in 22 cases of alopecia areata of a persistent inflammatory perivascular and perifollicular infiltrate, massive plugging of the ostia, disappearance of robust hair follicles and diminution in total number of hair follicles and sometimes fibrosis are not necessarily diagnostic of alopecia areata but seem to be very definitely characteristic. Treatment for alopecia areata is of little avail. At this time we do not recommend the general use of the corticosteroids despite the improvement of scalp appearance in the majority of instances in which the systemic administration of these hormones have been employed.


Biliary tract anomalies: the utilization of modern techniques in differential diagnosis. The diagnostic aids used in dealing with biliary disease in adults were applied to the study in infants of the principal congenital anomalies of the biliary tract such as choledochal cyst, biliary atresia and biliary stenosis. Choledochal cysts were distinguished from other upper abdominal masses occurring in childhood by the use of intravenous cholecystography. Since the clinical manifestations in infants with biliary atresia or stenosis are almost identical to those associated with the obstructive phase of neonatal hepatitis, the problem of differentiation is difficult. The serial total serum bilirubin curve, a careful analysis of the pigment content of feces and urine and duodenal intubation for bilirubin determinations were found to be useful in making the distinction. Operative cholangiograms were helpful in some cases. Frozen section examinations of liver tissue during operation were of little value except to demonstrate certain unusual cases of intrahepatic biliary atresia. Routine liver function studies, including serum transaminase determination in a limited number of cases, did not help in differentiation.


Frozen shoulder: methods for bringing about early mobilization. Frozen shoulder, rare in the young but more easily incurred after age 40, is a result of immobilization from any cause. Atrophy is the first phase, followed by shortening of soft tissues, pain on extension, spasm contractures and adhesions. Mobilization is urgent to prevent contractures. Rotation is the most important exercise, and should be done with the upper arm supported in nearly horizontal extension to prevent the humeral head from impinging on the acromion. From this position the forearm, lifting or pulling down in a forward are against weights and pulleys, restores the rotatory power of the shoulder.


Seizure problems in 250 cerebral palsied adults. Seizures occurred at some time in 81 (or 32 per cent) of an unselected, consecutive series of 250 cerebral palsied persons between the ages of 16 and 52 years, an incidence similar to that reported by other investigators in groups of cerebral palsied persons who were mainly children.The incidence of seizures of any kind after 16 years of age in the present series was 10 per cent as compared with 0.5 per cent in the general population. Half of the 10 per cent had more than six convulsions despite drug therapy, and the other half had fewer than six. Of thirty-six who had convulsions in the neonatal period, only four had seizure problems as adults, even though most showed moderate to severe physical handicap after age 16. Data on the small group of paraplegics in the present study, all spastics, were in accord with reports by other investigators with regard to decreased incidence of seizures in cerebral palsied patients with normal upper extremities. Of the thirteen (5 per cent of the 250) whose seizure problems continued to be clinically significant in adult life, ten had had frequent seizures in childhood. Eight were hemiplegic. There appeared to be no relationship between the severity of physical handicap and the incidence of seizures after age 16.


An intermediate psychiatric facility: the usefulness of a place for treatment between hospital and home. A new kind of psychiatric facility to deal with patients returning to their community from a state hospital or with patients newly ill and treatable locally, combines a number of features in the interests of economy and enhanced effectiveness. Its economy arises from: (1) The exclusion of bed-patient and security-ward care for patients not in need of them; (2) a shortened hospital stay resulting from rapid treatment procedures (electroconvulsion, brief psychotherapy and drug therapy); (3) a flexible shifting to outpatient or day care as soon as practicable. Enhanced effectiveness of therapy arises from earlier discharge from state hospitals, earlier treatment of patients from the community, as well as comprehensive utilization of multiple therapeutic modalities.


Suicide problems in medical practice.

Suicide problems in medical practice. Increasing awareness by physicians in general medical practice of the possibility of suicide in nonpsychiatric patients is indispensable for the evaluation of suicide risk and for a practical approach to the problem of prevention. An analysis was made of the records of 11 cases of suicide by medical and surgical patients who were in a general nonpsychiatric Veterans Administration hospital for evaluation and treatment of physical disease. It was noted that the general hospital staff had a low index of suspicion of the possibility of suicide in general hospital patients. It appeared from this study that there is a definite suicide risk in older persons hospitalized for physical illness who develop psychotic reactions during the course of their illness and hospitalization. The signs and symptoms of toxic and organic psychosis in these older patients were not recognized and their significance relative to suicide risk was not appreciated. Although psychiatric signs of severe emotional disturbance appeared clinically obvious at least 24 hours before suicide in ten of the eleven patients, no suicide risk was considered present, nor were adequate precautions taken by the hospital staff. This was owing to the lack of psychiatric orientation among the nonpsychiatric physicians.


Admittance of mental patients; a ten-year study of certification by health officer in Orange County. Seventeen states provide for admission of patients to mental hospitals by medical certification without judicial procedure. The aim is to avoid the police aspects of dealing with mentally ill persons without depriving them of constitutional rights. The California law, passed in 1947, has now had ten years' trial. In Orange County, 888 patients were examined under this act between 1947 and 1957. Of these, 486 were admitted to state mental institutions while 402 did not currently require hospitalization. Local modifications have provided additional safeguards to the patient, have made it more acceptable professionally, and have resulted in wider use of the act in Orange County.A comparison of costs between the medical certification procedure and court commitments indicated that, in 1957, court commitments were seven times more expensive than admissions by medical certification. The greater humanity of the procedure and the economy of it lead to the conclusion that, with a few changes, medical certification of mentally ill patients should be more widely used.


Ultrasonic therapy: physiological basis and clinical application. Ultrasound is a relatively new but fairly well accepted physical modality. Therapeutically, ultrasonic energy is employed empirically, but the present trend is to utilize low and medium intensities, 0.5 to 2.0 watts per square centimeter, rather than high intensities, over 2.0 watts per square centimeter, for medical purposes. The important physiological effects of ultrasonic energy on living tissue are thermal, mechanical, chemical and biological. Which one of these effects is dominant is not clearly understood. However, the intensity of the ultrasound field and the duration of application determines the extent to which the thermal or the mechanical effect prevails. From a clinical point of view ultrasonic energy has been most effective in the treatment of painful conditions involving the musculoskeletal and neuromuscular structures. More recently, studies have been directed toward the use of ultrasound as a neurosurgical tool.


Bilateral symmetrical aneurysms of the internal carotid arteries with spontaneous carotid cavernous fistula.


Cavitary carcinoma of the lung.

Cavitary carcinoma of the lung.


Observations on the effect of cortisone in a case of phenylpyruvic oligophrenia.


Serial cardiac output determinations in man.


The cardiovascular effects of halothane.


Fluothane-ether: an azeotropic mixture.

Fluothane-ether: an azeotropic mixture.


Properties of the fluothane-ether anaesthetic.


Trichlorethylene anaesthesia in obstetrics: a report.


Lumbar epidural anaesthesia for vaginal delivery.


The management of a post-poliolytic patient for major abdominal surgery.


Femoral nerve injury from abdominal retractors.


The tempo of change.

The tempo of change.


Construction at Campbell River.

Construction at Campbell River.


Vomiting, regurgitation, and aspiration in anaesthesia. II.


A guide to reading architectural drawings.


The Greater Niagara General; a hospital goes horizontal.


Planning for economy.

Planning for economy.


A maternity department to meet modern demands.


Welland County Hospital: how a hospital plan is developed.


Electrical design for a modern hospital.


Interior finishes: floors, walls, ceilings.


Canadian construction standards.

Canadian construction standards.


Communication; a tool.

Communication; a tool.


How to avoid medico-legal problems.

How to avoid medico-legal problems.


Air conditioning for the hospital.

Air conditioning for the hospital.


MEN AT work.

MEN AT work.


Dietary problems in the small hospital.

Dietary problems in the small hospital.


Using hospital resources effectively to maintain high quality patient care: laboratory and radiological services.


We are engaged in a social experiment.

We are engaged in a social experiment.


Renovation grants.

Renovation grants.


Using hospital resources effectively to maintain high quality patient care: medical aspects.


Using hospital resources effectively to maintain high quality patient care: necessary nursing.


Using hospital resources effectively to maintain high quality patient care: hospital administration.


A centennial celebration.

A centennial celebration.


Hotel Dieu, Kingston.

Hotel Dieu, Kingston.


A study on elevator services.

A study on elevator services.


Funds for the future by donations.

Funds for the future by donations.


Food production.

Food production.


The auxiliaries' services.

The auxiliaries' services.


Admitting problems solved.

Admitting problems solved.


Parotid secretion of protein in man.

Parotid secretion of protein in man.


Problems associated with the use of the exposed platinum electrode for measuring oxygen tension in vivo.


Action of antihistamines and tranquilizers on the conversion of fibrinogen to fibrin.


The influence of thiouracil on the responses of the immature pullet to estrogen, with reference to oviduct hypertrophy, serum calcium, and liver composition.


Studies of lignin biosynthesis using isotopic carbon. VI. Formation of the side chain of the phenylpropane monomer.


The use of furfural for the determination of acetone bodies in biological fluids.


The metabolism of the erythrocyte. XV. Adenylate kinase of the erythrocyte.


A controlled assay of clearing factor, and its application in studies of the role of heparin in clearing factor production.


Mechanism of action of the lactic dehydrogenase of the mammalian erythrocyte. I. Influence of inhibitors.


Mechanism of action of the lactic dehydrogenase of the mammalian erythrocyte. II. The mechanism of substrate inhibition.


Lactic dehydrogenase of the mammalian erythrocyte. III. The formation of a complex of the enzyme with DPN and lactate.


Thyrotrophic hormone activity in hypophysectomized rats exposed to cold and receiving ascorbic acid.


A rapid method for the large scale preparation of calf thymus deoxyribonucleate.


Determination of glucose in fish blood; a modification of the Folin-Malmros microprocedure.


The biosynthesis from acetate-1-C14 of fatty acids and cholesterol in formed blood elements.


Acetate and octanoate utilization by liver and adipose tissue of castrated and gonadal hormone-treated rats.


The effect of pyridoxine deficiency on blood urea in mice.


Studies on a lipoxidase system from sunflower seeds and seedlings.


Biocolloids in normal human urine. I. Amount and electrophoretic characteristics.


Biocolloids in normal human urine. II. Physicochemical and immunochemical characteristics.


Preparation of an estrone-protein conjugate.


The incorporation of C14-labelled formate into the tissue nucleic acids of rats bearing the Novikoff hepatoma.


Sodium, potassium, and lactic acid after muscular exercise in the rat.


The significance of the number of precipitin bands in agar gel medium for the determination of the complexity of antigens.


Restoration of hand function in rheumatoid arthritis.


Antagonists to schradan poisoning in mice.


A spectrometric study of the reactions of ketosteroids in sulphuric acid.


The formation of glycerophosphatides from C14-labelled precursors in rat brain slices.


Accidental home poisonings.

Accidental home poisonings.


Foster home care for the psychiatric patient.


A glossary of terms in cerebral palsy.

A glossary of terms in cerebral palsy.


Durafoam; a new material for making splints.


A plebiscite on continuing fluoridation in Thorold, Ontario.


Residue tolerances for pesticides in foods.


The Alberta Tuberculosis Association rehabilitation program.


The Manitoba Department of Health and Public Welfare.


A study of the needs of cancer patients in Waterloo county.


Some newer hazards in industry.

Some newer hazards in industry.


Changing needs in the control of swimming pools.


Frank Hamilton Mewburn.

Frank Hamilton Mewburn.


Islet cell tumours and peptic ulcers; a report of two cases of Zollinger-Ellison syndrome.


Carcinoma of the head of the pancreas; a study of twenty-one cases.


Postoperative acute pancreatitis.

Postoperative acute pancreatitis.


A simple plan of postoperative parenteral fluid therapy.


Perforation of the small intestine from non-penetrating trauma.


The surgical treatment of recurrent varicose veins.


The effect of narcotics on the serum amylase.


Rehabilitation of the elderly amputee.

Rehabilitation of the elderly amputee.


Patent ductus arteriosus; a review of thirty-six cases treated by surgery.


Homologous skin grafts; factors affecting survival and a report illustrating prolonged survival.


Stenosis of small intestine due to ischaemia following massive resection.


The present status of extracorporeal circulation.


Choledochus cyst with associated carcinoma.


Cancer of the thyroid: undifferentiated and miscellaneous carcinomas.


Solitary primary leiomyoma of the lung.

Solitary primary leiomyoma of the lung.


Cystinuria: review of literature: genealogy and report of a case with recurrent urolithiasis.


Massive upper gastrointestinal bleeding from spontaneous laceration of the lower oesophagus (Mallory-Weiss syndrome).


Chordoma of the dorsal spine.

Chordoma of the dorsal spine.


Evaluation of the effectiveness of anti-influenza vaccination.


Subarachnoid haemorrhage, 1951-1958: 108 cases.


Haemorrhagic effect of ACTH with anticoagulants.


Symposium on the management of coronary heart disease.


Mesenteric infarction: a clinical study of 49 cases.


The surgical treatment of transposition of the great vessels: report of two clinical cases.


Blood coagulation in subjects with and without clinical evidence of atherosclerotic vessel disease.


Intravenous polyethylene catheter successfully removed from the heart.


Aortic valvular insufficiency associated with rheumatoid arthritis.


Basilar artery occlusion: report of a case with ten years' survival.


Oesophagobronchial fistula complicating oesophageal diverticulum.


LUNG CANCER and smoking.

LUNG CANCER and smoking.


ENCEPHALOPATHY and influenza.

ENCEPHALOPATHY and influenza.


Obesity.

Obesity.


Medical treatment of hypertension.

Medical treatment of hypertension.


INSECTICIDE resistance.

INSECTICIDE resistance.


New light on patellectomy.

New light on patellectomy.


Personality factors in the healing process.


Dr. Alfred Turner Bazin.

Dr. Alfred Turner Bazin.


Injuries to the sacral plexus in obstetrics.


Hypersensitivity myocarditis occurring with sulfamethoxypyridazine therapy.


Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus.


The status of phenylbutazone (butazolidin) in the treatment of rheumatic disorders.


Durafoam; a new material for rest splints in the prevention of deformity in the chronic rheumatic diseases.


The sheep erythrocyte agglutination test in rheumatoid arthritis.


Diverticulum of the female urethra; an overlooked condition.


Mycotic abscess of the brain probably due to Cladosporium trichoides: report of the fifth case.


Multiple myeloma (large cell type) in a 24-year-old woman with normal total protein and latent electrophoretic changes.


Gangrene as a complication of malrotation with volvulus.


The experimental production of atherosclerosis in swine following the feeding of butter and margarine.


The Canadian Association for Retarded Children.


A comparison of intravenous calcium disodium versenate and oral penicillamine in promoting elimination of lead.


Aortic occlusion.

Aortic occlusion.


An encouraging report.

An encouraging report.


ADOLESCENT medicine; a new specialty?

ADOLESCENT medicine; a new specialty?


NATIONAL Health Service in the United Kingdom.


Premalignant fibroepithelial tumour of Pinkus.


Anorexia nervosa: a somatic disorder.

Anorexia nervosa: a somatic disorder.


The relief of deafness by the newer operations.


ALFRED TURNER BAZIN.

ALFRED TURNER BAZIN.


Tranquillizers and other psychotropic drugs in clinical practice.


End results in the current treatment of forearm fractures.


Fetal hazards in the diabetic pregnancy.


The function of the physician in industry.


Cultivation of Leishmania donovani in human amnion epithelial cell tissue cultures: a preliminary report.


Studies of adrenal cortical function in three cases of carcinoma.


Blood coagulation during alimentary lipaemia in subjects with and without clinical evidence of atherosclerosis.


Ristocetin: a clinical trial.

Ristocetin: a clinical trial.


The use of exchange transfusion in acute renal failure.


Malignant granuloma of the nose.

Malignant granuloma of the nose.


A fatal B virus infection in a person subject to recurrent herpes labialis.


The use of triamcinolone (aristocort) in selected dermatoses.


Serum penicillin levels after the oral administration of a long-acting tablet.


The treatment of dysmenorrhoea with phenylbutazone.


Hypoglycaemia and hyperinsulinism.

Hypoglycaemia and hyperinsulinism.


The world at your finger-tips.

The world at your finger-tips.


Our common heritage.

Our common heritage.


The retirement plan.

The retirement plan.


Sociogramatic study of spontaneous patient groupings.


The inspection of ward drug cabinets.

The inspection of ward drug cabinets.


Thyroid conditions.

Thyroid conditions.


Anesthesia for open heart surgery.

Anesthesia for open heart surgery.


Melanotic sarcoma.

Melanotic sarcoma.


An exploratory laparotomy.

An exploratory laparotomy.


Nurses and new parents.

Nurses and new parents.


A part of the deep flow.

A part of the deep flow.


The cancer problem.

The cancer problem.


Early detection and the nurse.

Early detection and the nurse.


Educating the nurse in cancer care.

Educating the nurse in cancer care.


Nursing the cancer patient.

Nursing the cancer patient.


Psychological problems of the cancer patient.


Gynecological cancer; diagnosis and treatment.


The public health nurse in the cancer program.


Nursing care in radiation therapy.

Nursing care in radiation therapy.


The organization and operation of a cancer welfare program.


Some notes on Paul Grawitz and his tumor.


A new and rapid method for diagnosis of vaginal and cervical cancer by fluorescence microscopy.


Glioblastoma and fibrosarcoma of the brain with extracranial metastases.


Papillary cancer of the thyroid; a review of 25 years of experience.


Primary malignant melanoma of the oral cavity: a review of 105 cases.


Genetic studies of gastric cancer in humans: an appraisal.


The combined effect of radiogold and nitrogen mustard and radiogold and certain other compounds on the Ehrlich ascites carcinoma.


Effects of pantothenic acid-deficient diets in patients with carcinomas.


Breast carcinoma and ABO blood groups.

Breast carcinoma and ABO blood groups.


The association of invasive and in situ anaplastic bronchogenic carcinoma of the oat cell type; report of 2 cases.


The use of sulfur dioxide as a diagnostic aid in pulmonary cancer; preliminary report.


Melanotic progonoma (retinal anlage tumor) of the shoulder in an infant; a case report.


Prostatic cancer. VII. Serum acid phosphatase response to cholinergic stimulation in prostatic cancer patients.


A recheck of kindred 107, which has shown a high frequency of breast cancer.


Needle biopsy of pleura; an evaluation in patients with pleural effusion of neoplastic origin.


Studies of nitrogen metabolism in human cancer using isotopically labeled L-aspartic acid.


Urinary steroid excretion and other biochemical indexes in prostatic cancer in relation to therapy.


The effect of HN2 on hemoglobin synthesis by avian erythrocytes in vitro.


Primary hyperparathyroidism and metastatic breast carcinoma: a case in which breast carcinoma metastasized to a parathyroid adenoma.


[Responsibilities to & of dentistry].

[Responsibilities to & of dentistry].


Partial hepatectomy for primary carcinoma of the liver in childhood.


Inhibition of local tumor implantation with triethylenethiophosporamide (TSPA).


The effects of varying steroid therapy on metastatic mammary carcinoma after adrenalectomy.


Bone and joint tuberculosis in Kenya.

Bone and joint tuberculosis in Kenya.


THE IMPORTANCE of cytology to the practicing physician.


Clinicopathological correlations in a series of 117 malignant melanomas of the skin of adults.


Oxycephaly in an African child associated with other abnormalities.


The African and plastic surgery.

The African and plastic surgery.


Squamous cell papillomas of the uterine cervix; a report of 20 cases.


The effect of nitrogen mustard on adrenal cortex function.


The prevention of maternal death.

The prevention of maternal death.


An account of the opening of the African Women's clinic: Msasa Hospital of the Imperial Tobacco Company Salisbury.


GARGOYLISM.

GARGOYLISM.


Cardiac disease of obscure origin in Africa.


PROGNOSIS in ovarian cancer.

PROGNOSIS in ovarian cancer.


The baobab tree: a good source of ascorbic acid.


Portal hypertension.

Portal hypertension.


The assessment of muscular hypertrophy and endarteritis obliterans in pulmonary arteries.


FAMILIAL polyposis.

FAMILIAL polyposis.


The artificial heart.

The artificial heart.


The effects of chemotherapy and irradiation therapy on the differentiation of experimental tumors.


THERAPY in urinary bladder cancer.

THERAPY in urinary bladder cancer.


BONE MARROW transplants.

BONE MARROW transplants.


The practice of tropical medicine from the consultant's chair.


Actue poliomyelitis in Europeans admitted to the Walker Wilkins Infectious Diseases Hospital, Salisbury.


The first school of medicine in southern Africa.


Diabetes mellitus; some problems.

Diabetes mellitus; some problems.


The opening of the new Mpilo African Hospital.


[Method of managing the 3d stage of labor].


[60th Birthday of Dr. Vladimír Hlavácek].


[Adrenal radiographic findings in patients with hyperfunctional syndromes].


4, 5-Substituted pyridazines. V. Acylation of 4-amino-3, 6-dichloropyridazine.


Studies on pyrimidine derivatives. I. Synthesis of thiazolo (5, 4-d)-pyrimidines and related compounds. 1.


Studies on pyrimidine derivatives. II. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 2.


Studies on pyrimidine derivatives. III. Synthesis of thiazolo(5, 4-d) pyrimidines and related compounds. 3.


Studies on pyrimidine derivatives. IV. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 4.


Studies on pyrimidine derivatives. V. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 5.


Studies on pyrimidine derivatives. VI. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 6.


Structure of longifolene.

Structure of longifolene.


Synthesis of rac-dihydrorotundine.

Synthesis of rac-dihydrorotundine.


Sulfur-containing pyridine derivatives. LVI. Smiles rearrangement of pyridine derivatives and synthesis of benzopyrido- and dipyrido-1, 4-thiazine derivatives. 4.


Synthesis of analgesics. XIX. Antipyrine derivatives. 6.


Synthesis of related compounds of thiosemicarbazide. IV. 1-(1, 3, 4-Thiadiazol-2-yl)-2-pyrazolin-5-one and tetrazolo(4, 5-a)-1,3, 4-thiadiazole derivatives.


Microbiological hydroxylation of steriods. IV. 7a, 15 beta-Dihydroxylation of progesterone by Syncephalastrum sp. 2.


Studies on acylase activity and microorganisms. VIII. Enzymatic hydrolysis of 6-N-benzoyl-L-lysine.


Studies on acylase activity and microorganisms. IX. Enzymatic resolution of tryptophan by a strain of soil bacteria.


Studies on the constituents of the seeds of Cassia obtusifolia L. I. The structure of obtusifolin.


Studies on naphthyridines. III. Syntheses of 2, 10-diazaanthracene and 1, 7-naphthyridine.


Studies on naphthyridines. IV. Infrared spectra of naphthyridines.


Studies on naphthyridines. V. Catalytic reduction of naphthyridines.


Organic analysis. X. Reaction mechanism of 5-hydroxytetralone with glucose.


Organic analysis. XI. Infrared spectra of phenylsulfonyl derivatives. 1.


Studies on determination of sapogenins in plants belonging to Dioscorea growing in Japan. II. Determination of diosgenin, tokorogenin, and a new genin contained in the roots.


Nonaqueous polarography of quinones. V. Half-wave potentials of o-quinones in relation to carcinogenesis of polyaromatic hydrocarbons.


Studies on the syntheses of hydrogenated quinolines and isoquinolines as analgesics, XV. Synthesis of 3-hydroxy-N-methyl-7-aza-des-N-morphinan (9-hydroxy-3-methyl-5, 10b-trimethylene-1,2,3,4,4a,4,6, 10b-octahydrobenzo(f)isoquinoline.


Structure of the condensation product of isonicotinylhydrazine and sodium glucuronate.


Bile acids and steroids. X. On beta-spinasterol.


Studies on acylase activity and microorganisms. X. Enzymatic resolution of alloisoleucine by soil bacteria, KT 85 (Pseudomonas sp.).


On the nomenclature of the fluorescent substances produced in the culture of Eremothecium ashbyii.


Several 2, 3-cyclic phosphates of D-ribofuranoside and their properties as substrate of ribonuclease.


The people's boundless energy during the current leap forward. I. New victories on the antischistosomiasis front.


II. Intensive tartar emetic treatment in schistosomiasis japonica.


Further observations on the transmission of Wuchereria malayi by A. hyrcanus var. sinensis.


Immunological studies in experimental schistosomiasis japonica.


Histoplasmosis; report of a case.

Histoplasmosis; report of a case.


The mechanism of microfilarial periodicity.


The value of cercariae membrane reaction in the diagnosis of schistosomiasis japonica.


Observations on skeletal development in schistosomiasis dwarfism.


Oxygen treatment of ascariasis in children.


The changing clinical picture of scarlet fever during recent years.


Hemagglutination of Japanese B encephalitis. I. Preparation and properties of dried hemagglutinin.


II. Study of the inhibitor in the mouse brain.


Chlorpromazine and heat reducing measures in treatment of heat stroke.


Anal protrusion of ovarian cyst complicating labor.


Hypersensitiveness to pituitrin with acute circulatory failure; report of a case.


Work and heart disease. I. A physiologic study in the factory.


Strokes; progress and problems.

Strokes; progress and problems.


Ventricular septal defect in infants and children; a correlation of clinical, physiologic, and autopsy data.


Reverse Wenckebach block and complete atrioventricular dissociation due to potassium and digitalis.


The diagnosis of circulatory shunts by the nitrous oxide test; improvements in technic and methods for quantification of the shunt.


The clinical measurement of retinal arterial pressure.


Patent ductus arteriosus with pulmonary hypertension simulating ventricular septal defect; diagnostic criteria in ten surgically proven cases.


Excessive urinary 5-hydroxy-3-indole acetic acid in the absence of a metastatic carcinoid.


Functional diagnosis of patent ductus arteriosus studied by cineangiocardiography in fifty-three cases.


Acute myocardial infarction revealed in an isolated premature ventricular beat.


Supravalvular aortic stenosis.

Supravalvular aortic stenosis.


Cardiac arrhythmias associated with the repair of atrial and ventricular septal defects.


Traumatic rupture of interventricular septum proved by cardiac catheterization.


Cardiac rupture due to metastases from a carcinoma of the antrum.


Syndrome of carotid artery insufficiency; early clinical recognition and therapy.


The survival of excitability, energy production and energy utilization of the heart.


Endocardial and intimal lesions (jet impact) as possible sites of origin of murmurs.


Radiologic technic for qualitative and quantitative study of blood flow.


Origin of heart sounds as elucidated by analysis of the sequence of cardiodynamic events.


Genesis of pistol-shot and Korotkoff sounds.


Intracardiac phonocardiography: correlation of mechanical, acoustic and electric events of the cardiac cycle.


Correlation of heart sounds and murmurs with pressure during left heart catheterization.


Intracardiac phonocardiography in mitral and aortic value lesions.


Present status of intracardiac phonocardiography.


The pulmonary valve in direct phonocardiography.


Correlation of heart sounds with ejection dynamics of the right ventricle.


Mechanisms of fixed splitting of the second heart sound.


Physiologic splitting of the second heart sound.


The tricuspid component of the first heart sound in mitral stenosis.


Clinical aspects of gallop rhythm with particular reference to diastolic gallops.


The Austin Flint murmur: its differentiation from the murmur of rheumatic mitral stenosis.


Auscultatory findings in pericardial effusion and in ventricular aneurysm.


Mammary souffle of pregnancy: report of two cases simulating patent ductus arteriosus.


The normal systolic murmur.

The normal systolic murmur.


Analogs, models and equations.

Analogs, models and equations.


The response to catechol amine infusion during salicylate-induced hypermetabolism in man.


Acetylcholine and electrolyte metabolism in the various chambers of the frog and turtle heart.


Statistical properties of pulsatile pressure and flow in the femoral artery of the dog.


An electron microscopic study of myocardial ischemia in the rat.


Circulatory and renal adjustments to acute femoral arteriovenous fistulas.


The effect of complete ischemia on the intracellular electrical activity of the whole mammalian heart.


The development of collateral circulation in the mouse's ear.


Pressure and oxygen content measurements distal to temporary and permanent unilateral occlusion of a pulmonary artery in dogs.


Effect of purine and pyrimidine ribosides on an isolated frog ventricle preparation.


A serum protein system affecting contractility of the frog heart present in increased amounts in patients with essential hypertension.


Inhibition of levarterenol by intra-arterial phenoxy-benzamine in man.


Chemical agents capable of affecting lipid metabolism in the aorta.


Studies of the rate of transfer of Rb86, K39, Na24, Na23, Cl 36, and C1 35 across the pericardium of dogs.


Cardiac hypertrophy in rats with phenylhydrazine anemia.


Effect of temperature on the heart rate, electrocardiogram and certain myocardial oxidations of the rat.


Polarographic oxygen, the epicardial electrocardiogram and muscle contraction in experimental acute regional ischemia of the left ventricle.


Effect of biphenylylbutyric acid on the cholesterol and phospholipid metabolism in the rat.


Effect of glucose on appearance of plasma-clotting accelerator activity, lactescence, and plasma lipids in fat-fed dogs.


Do ganglion-blocking agents and reserpine affect central vasomotor activity?


Diverse distribution of red cells and albumin in the dog kidney.


Further observations on the effects of thyroid hormone preparations on cholesterolemia and atherogenesis in cholesterol-fed cockerels.


The importance of thiol compounds in the causation of disease.


Seromucoid (mucoprotein) determinations in experimental animals.


Renal failure during acute hypercalcaemia in patients with metastasized mammary carcinoma.


On the effect of DPN on the conversion of 3-hydroxyanthranilic acid to quinolinic acid in presence of hepatic tissue of rats affected by Oberling's myeloma in the leukemic phase.


Determination of unesterified fatty acids in normal human plasma.


Small-scale membrane filter electrophoresis and immuno-electrophoresis.


Performance of the sweat test under standardized conditions.


An ultra-micro method for determination of amylase activity in blood serum.


Enzymic studies in small amounts of human tissue with the help of microanalytical methods. III. Energetic metabolism of cirrhotic and precirrhotic liver tissue removed by needle biopsy.


Rapid electro-phoretic separation of hemoglobins and serum proteins.


Depolymerization of the 19S antibodies and the 22S rheumatoid factor.


Zone electrophoresis on filter paper: a simple modification to the horizontal type of apparatus to reduce handling of the strips.


Studies in dysproteinemia. I. Clinical significance of some abnormal aspects of the electrophoretic pattern.


Microbiologic determination of codehydrogenase in blood of patients with ulcerative lesions.


The stability of lactic dehydrogenase in serum.


Determination of serum lipo-proteins by paper electrophoresis after preliminary staining with Sudan black-B.


Evaluation of glucose determinations in untreated serum samples.


Sources of variation in a standardized and a semi-micro procedure for the spectrophotometric assay of serum glutamic-oxalacetic transaminase concentration.


The assay of urinary peptides using a biuret reagent.


William St. Clair Bauld: 1919-1958.

William St. Clair Bauld: 1919-1958.


The psychogenic aspects of bronchial asthma.


Cystic fibrosis.

Cystic fibrosis.


Gangrenous purpura associated with meningococcemia.


Mumps orchitis.

Mumps orchitis.


Herpes zoster facialis.

Herpes zoster facialis.


Selection of representative sites for measuring changes in human subcutaneous tissue thickness.


The relation of the thyroid to the calorigenic response to salicylate.


Etiological considerations of newly isolated viruses.


Studies of erythrocyte phosphate ester metabolism in galactosaemia.


Factors influencing arterial blood pressure in the general polulation.


The Christmas factor deficiency in coumarin therapy.


Sex differences in plasma fibrin, fibrinolytic capacity and lipids as influenced by ingested fat, gonadectomy and hormone implants; possible implications for pathogenesis of coronary occlusion.


The influence of chronic liver infection in experimental nutritional hepatic fibrosis.


The diffusing capacity of the pulmonary membrane and the pulmonary capillary blood volume in cardiopulmonary disease.


The measurement of the phase distribution of water and electrolytes in skeletal muscle by the analysis of small samples.


Further observations on the production of plasma fibrinolytic activity within veins: response to various stimuli.


Description and evaluation of a dextran-dilution technique for the determination of plasma volume in the dog and man.


Effect of thyroxine, triiodothyronine and triac on metabolic rate, blood lipids and thyroid size and function in subjects with non-toxic goitre.


The role of proteins in the production of an experimental nutritional hepatic fibrosis.


Red cell and total blood volume changes following a minor operation.


Variations in thyroid function in normal subjects.


[Effects of chlorpromazine & reserpine on sensitivity of the guinea pig to 5-hydroxytryptamine administered in aerosols].


[Formation of nuclei & multipolar mitoses in the ovum during segmentation].


[Prevention of highway accidents].

[Prevention of highway accidents].


[Surgery of pain: the electric finger].

[Surgery of pain: the electric finger].


[Alcoholism in rural areas: causes & prevention].


[Various thorax injuries: history & didactics].


A study of leptospirosis in large artificial insemination stud.


Carcinoma of the pancreas in the dog.

Carcinoma of the pancreas in the dog.


An outbreak of hemorrhagic pneumonia in mink; a case report.


Lactation in a virgin heifer.

Lactation in a virgin heifer.


An indirect hemagglutination test for detecting infectious canine hepatitis virus antibodies.


The fetal drain of hexose in ovine pregnancy toxemia.


Successful closure of a patent ductus arteriosus in the dog; report of a case.


A pleuropneumonialike organism and a virus in ovine pneumonia in California.


Bovine congenital porphyria (pink tooth), with a note on five cases observed in Jamaica.


Parasitism by Cheyletiella parasitivorax; a case report of the infestation in a female dog and its litter.


A histochemical study of five cases of leiomyometaplasts in dogs.


Infectious pustular vulvovaginitis of cattle.


Rabies prophylaxis in man.

Rabies prophylaxis in man.


Pulmonary failure.

Pulmonary failure.


Diffuse scleroderma; a clinical study of sixty-five cases.


Serum proteins in scleroderma.

Serum proteins in scleroderma.


Human rabies prophylaxis report of a clinical study in Delaware.


Radiologic aspects of cardiac catheterization.


Early recognition of cerebral palsy.

Early recognition of cerebral palsy.


Some changing concepts in metal retardation.


Notes on cardiac catheterization.

Notes on cardiac catheterization.


Invenol in the therapy of psoriasis; preliminary report.


Does your patient have a social problem.


An evaluation of radiation tolerance levels.


REPORT of Salk poliomyelitis vaccination status in Delaware.


Surgery for the cardiac patient.

Surgery for the cardiac patient.


The surgery of cardiovascular disease.

The surgery of cardiovascular disease.


Experiences with percutaneous needle biopsy of the liver.


Use of radioactive iodine in evaluation and treatment of cardiac problems.


Mental rehabilitation of the patient with myocardial infarction.


[Value of oral aminitrozole in progress of treatment of Trichomonas vaginitis].


[Diagnosis and treatment of male fertility disorders].


[Postmature newborn; studies on the clinical picture and therapy of so-called postmaturity].


[Diagnosis of frequent forms of respiratory insufficiency with spirometric methods].


[Cancer of the esophagus: surgical treatment with special reference to cancer of the middle section].


Uncommon roentgen patterns of pulmonary sarcoidosis.


A characterization of atypical acid-fast bacilli obtained from patients with pulmonary tuberculosis.


Considerations in humidification by nebulization.


Temporary collapse in the treatment of pulmonary tuberculosis.


The application of hypothermia in the correction of cardiovascular lesions: a study of 140 cases.


Atrial septal defect: an evaluation of surgical closure.


Angina pectoris and premature systoles induced by exercise.


Paroxysmal pseudoventricular fibrillation: paroxysmal atrial fibrillation with accelerated atrioventricular conduction.


Reversible angina pectoris.

Reversible angina pectoris.


Pulmonary sporotrichosis.

Pulmonary sporotrichosis.


Sensitivity to tuberculin, histoplasmin and coccidioidin among high school students in Northwestern Georgia.


Pulmonary resection for tuberculosis under protection of viomycin, promizole and pyrazinamide.


Echinococcus cyst of the lung.

Echinococcus cyst of the lung.


Pulmonary ray fungus disease; clinical aspects and pathogenesis.


Treatment of spontaneous pneumothorax with kaolin.


Bronchogenic carcinoma in men under 40 years of age.


The value of left heart catheterization in patients with rheumatic mitral valve disease.


The frequency of tricuspid stenosis with particular reference to cardiac surgery.


Postoperative coronary thrombosis and myocardial infarction.


The selection of an antibiotic for the treatment of bacterial endocarditis.


The electrocardiogram of the month.

The electrocardiogram of the month.


Diffuse interstitial fibrosis of the lungs (Hamman-Rich syndrome); successful palliation of a case with steroid therapy.


Chronic tracheopathia osteoplastica; a case report.


Results of drug treatment of non-hospitalized tuberculous patients compared with those immediately hospitalized.


Interpersonal theory and intensive psychotherapy procedure.


Acute toxic psychosis due to scopolamine; a case report.


Use of perphenazine in 100 hospitalized patients.


Factors in patients' failure to return to clinic.


Combination reserpine-methylphenidate in epileptics with psychosis; final report.


Applicability of sustained-release psychopharmacologic agents to psychiatric treatment.


Symposium on major variations and modifications of conventional electric shock therapy; introduction.


Non-convulsive electrocerebral stimulative therapy.


Evaluation of therapeutic results of electric stimulation of the diencephalon.


Peripheral electrical stimulation.

Peripheral electrical stimulation.


Multipolar electrocoma therapy.

Multipolar electrocoma therapy.


Monopolar electrocerebral therapy.

Monopolar electrocerebral therapy.


Brain measurements electronically determined and correlated physical treatment: basic method.


The psychodynamics of filicide and matricide.


Symbolic language discrimination in psychomotor epilepsy.