Intensive care: effective care.

Intensive care: effective care.


Patron saints of Catholic hospitals.

Patron saints of Catholic hospitals.


Library service: international style.

Library service: international style.


Make lay advisory boards effective.

Make lay advisory boards effective.


Social patterns in mental illness.

Social patterns in mental illness.


The psychological approach in medical and surgical nursing.


Patient-centered cardiac care.

Patient-centered cardiac care.


Hospital menus reflect the liturgy.

Hospital menus reflect the liturgy.


Who is the nursing supervisor?

Who is the nursing supervisor?


Radiographer or button pusher?

Radiographer or button pusher?


Housekeepers can solve space problems.

Housekeepers can solve space problems.


Escort service saves time, money, personnel.


What's the matter with publicity?

What's the matter with publicity?


Effective lab coverage nights and weekends.


Operation safety.

Operation safety.


A case study of Sparks Manor: designed for elderly residents.


The patient has something to say.

The patient has something to say.


Rehabilitating the rehabilitation concept in the general hospital.


They practice now to save lives later.

They practice now to save lives later.


The meaning of control.

The meaning of control.


How this hospital competes in the local labor market.


The who and what of delegation: to whom to delegate; what to delegate.


Putting value analysis to work for hospitals.


One-use waste receptacles minimize infection spread.


An interview with George Bugbee.

An interview with George Bugbee.


The company a budget keeps determines its effectiveness.


This hospital learned to grow by planned leaps.


Management looks at the community.

Management looks at the community.


Surgical instruments: serious gap in national defense.


National intern matching program: seventh annual report.


True evaluation of disposables looks past the cost factor.


How to adjust recipe yields quickly and accurately.


Sterilizer maintenance: perfection is the standard.


The malpractice suit and you.

The malpractice suit and you.


Common kidney diseases.

Common kidney diseases.


How shall we judge?

How shall we judge?


Lung cancer and cigarettes.

Lung cancer and cigarettes.


The relationship of potassium deficiency to congestive heart failure.


The detection of uterine cancer in women after 60.


Lymphangiosarcoma: late complication of mastectomy.


Septic thrombophlebitis of the leg with mural endocarditis and pulmonary embolism.


VANDALIA physician named Illinois GP of the year.


Immune-adherence with soluble antigens.

Immune-adherence with soluble antigens.


Fluorescent protein tracers; a trial of new fluorochromes and the development of an alternative to fluorescein.


The separation of the histamine-sensitizing factor from the protective antigens of Bordetella pertussis.


The opsonic effect of normal serum on the uptake of bacteria by the reticulo-endothelial system; perfusion studies with isolated rat liver.


Estimation of tetanus toxoid by different methods, including haemagglutination inhibition.


Electron microscopic studies of the antigen-antibody complex.


Proliferation of chick embryonic heart fibroblast in various media. II. A quantitative differentiation of proliferating, surviving and deteriorating cultures of chick embryonic heart fibroblast tissue.


Experimental peptic ulceration. IV. Effect of mucous stimulants on histamine-induced ulceration.


Ponderal and histologic changes in the adrenal cortex of castrated rats after treatment with triiodothyronine.


Relationship of socio-economic conditions with blood cholesterol.


Determination of basal metabolic rate and blood concentrations of protein-bound iodine, cholesterol and glucose in Indians.


Studies on biochemical and hematological changes produced by electric convulsion therapy in patients suffering from schizophrenia.


Respiratory jaw reflex.

Respiratory jaw reflex.


Bound ascorbic acid contents of germinated leguminous seeds.


Antiarrhythmic and anticonvulsant activity of jatamansone.


Antiarrhythmics. X. Antiarrhythmic and antiveratrinic action of some antihistaminic drugs.


Effectiveness of some anticonvulsant drugs in ventricular tachycardia resulting from acute myocardial infarction in the dog.


Evaluation of some indigenous drugs for stimulant effect on the rat uterus: a preliminary report.


The site of absorption of orally administered vitamin B12 in dogs.


The effect of protein deficiency on the liver of albino rats. I. The influence of different levels of dietary protein on total nitrogen, succinic dehydrogenase and xanthine oxidase in liver.


Nutritive value of duck egg white. VI. Further observations on the growth retarding property of DEW ovomucoid.


Diet surveys in Delhi (1957).

Diet surveys in Delhi (1957).


Biological factors in transmission of human leprosy to laboratory animals. I.


Studies on transmission of human leprosy to laboratory animals. II.


Clinical evaluation and toxicity of sulfamethoxypyridazine; a long acting new sulfonamide.


Resistance to cancer; an immunological approach. I.


Toxic psychosis associated with sulfamethoxypyridazine (lederkyn).


Resistance to cancer; an immunological approach. II.


Cystic disease of the lung associated with pituitary hyperfunction; case report.


The behaviour of serum protein factors in pregnancy and puerperium.


Congenital galactosemia; case report.

Congenital galactosemia; case report.


ABO and AB blood groups in Punjab.

ABO and AB blood groups in Punjab.


Renal diseases in diabetes mellitus.

Renal diseases in diabetes mellitus.


The vitamin. 8. Vitamin B12 (cyanocobalamin). I.


Use of cortisone in the treatment of cerebral infarction.


An aid to the diagnosis of giardiasis in children.


Glycogen storage disease of the liver.

Glycogen storage disease of the liver.


Alkaptonuria.

Alkaptonuria.


The rat diaphragm method and plasma insulin estimation.


Blood glutathione and ascorbic acid in normal pregnancy and in pre-eclamptic toxaemia.


Influence of various biochemical and haematological factors on packed cell volume.


A preliminary study on the effects of superficial application of salt solution on living frogs.


Studies on anti-diuretic action of protein hydrolysate.


Industrial thallium intoxication.

Industrial thallium intoxication.


Blood urea clearance in young Indonesian subjects.


Management and union health programs; the coordination of care and public understanding and acceptance of health services.


Para nitrobiphenyl, a new bladder carcinogen in the dog.


Disaster ambulance; mobile first aid station.


Immunization against influenza in industry.


Immunological factors in the pathogenesis of the hyaline tissue of silicosis.


Profiles in occupational health: Andrew Meiklejohn.


Alcoholism: the concern of industry and the community.


THE CHANGING American family and the woman labor pool.


Government's role in preventive medicine.


Magnification techniques in radiography.


Whiplash.

Whiplash.


Asian type A influenza; results of an industrial immunization program.


Inoculation against Asian influenza.

Inoculation against Asian influenza.


EVOLUTION in Chrysler Corporation's medical department.


Calcium45 deposition during induced atherosclerosis.


Chronic low back pain.

Chronic low back pain.


Ventilation for human occupancy; a disaster of historic import.


A case report on the strange phenomenon that turns men blue: methemoglobinemia.


Grass pollen extracts. I. The general properties of aqueous extracts of rye grass pollen.


Grass pollen extracts. II. The fractionation of dialysed rye pollen extracts.


Grass pollen extracts. III. Some chemical and physical properties of fractions from rye pollen extracts.


Grass pollen extracts. IV. The biological activity of rye pollen extracts and their fractions.


Comparison of the release of histamine and 5-hydroxytryptamine from tissues of the rat, mouse and hamster.


Air pollution and cancer mortality in Liverpool Hospital region and North Wales.


Polycyclic hydrocarbons in rural and urban air.


The effect of pollution on radiation in the atmosphere.


Some factors in the design, organization and implementation of an air hygiene survey.


Coalescence of droplets in aqueous-disperse aerosols.


The application of phenolphthalin reagent to atmospheric oxidant analysis.


The atmospheric pollution of cities.

The atmospheric pollution of cities.


A study of the average distribution of pollution around Staythorpe.


The atmospheric diffusion of gases discharged from the chimney of the Harwell reactor BEPO.


A study of the radon content of ground-level air at Harwell.


The technical provisions of the British Clean Air Act.


Smoke pollution and household costs.

Smoke pollution and household costs.


Atmospheric chemistry.

Atmospheric chemistry.


Ernest Jones.

Ernest Jones.


Josef Breuer's evaluation of his contribution to psycho-analysis.


Dr. Ernest Jones.

Dr. Ernest Jones.


Trauma and arthritis.

Trauma and arthritis.


Medicolegal outlines of consent.

Medicolegal outlines of consent.


Freud the translator: some contacts with philosophy.


ERNEST JONES: funeral addresses.

ERNEST JONES: funeral addresses.


Trauma in urology.

Trauma in urology.


On hallucination.

On hallucination.


The present problem of malpractice.

The present problem of malpractice.


Ernest Jones: his contribution to psycho-analytic theory.


Freud's death instinct and the second law of thermodynamics.


A cure for physician-lawyer frictions.

A cure for physician-lawyer frictions.


The nature of the child's tie to his mother.


On the nature and aims of psycho-analytical treatment.


Preliminary report: prednisolone in an aerosol spray.


The search for tranquility.

The search for tranquility.


Perphenazine in allergic conditions.

Perphenazine in allergic conditions.


An enquiry into the function of words in the psycho-analytical situation.


The three areas of the mind: theoretical considerations.


Analysis of a patient with a split personality.


CL Galen.

CL Galen.


The capacity to be alone.

The capacity to be alone.


Energy-speed relation and optimal speed during level walking.


Clinical thought-reading.

Clinical thought-reading.


Manometric determination of cocarboxylase in pure solution, in blood and in animal tissues.


Cocarboxylase content of tissues of mice treated with pyrithiamine or oxythiamine.


The content of vitamin B6 in Danish foods.


CLINICAL report of the Rotunda Hospital; 1st November, 1956 to 31st October, 1957.


NATIONAL Maternity Hospital, Dublin; clinical report.


Coombe Lying-in Hospital Dublin; clinical report for the year 1957.


Histochemical demonstration of hydroperoxidase activity by two improved methods different in their mechanisms.


New varieties of Catenabacterium helminthoides and Fusobacterium vescum isolated from mud-snails.


Additional type E botulism outbreaks in Hokkaido, Japan.


The studies on the fluid environment of ascaris: influence of pH and effect of antibiotics and antimycotics (dehydroacetic acid) in fluid media upon the survival length and the duration of normal locomotion.


Some aspects of bacterial mutation from streptomycin dependence to nondependence in a strain of tubercle bacilli.


Further analysis of bacterial mutation from streptomycin dependence to nondependence in a strain of tubercle bacilli, particularly in association with acriflavine resistance.


An evaluation of the plate complement fixation test with Japanese B encephalitis and polio viruses.


Studies on the metabolism of murine leprosy bacilli. II. Substances, contained in mitochondria extract of rat liver, which stimulate the metabolism of bacilli and some enzyme systems in the bacilli.


Studies on the metabolism of murine leprosy bacilli. I. Stimulating effect of mitochondria extract of rat liver on the metabolism of bacilli.


[Various pathogenic aspects of diabetic acidosis & its therapeutic implications].


The patient, the tooth and the dentist: a modern perspective of tooth preparation.


Treatment of functional occlusal disharmonies.


A comparison of the properties and uses of silicate cement and acrylic resin in operative dentistry.


Caries-inhibiting value of a dentifrice containing stannous fluoride: final report of a two year study.


The caries-inhibiting effect of dibasic sodium phosphate and dibasic calcium phosphate added to wheat flour and bread diets.


Preliminary investigation of some basic problems of instrument sterilization.


The response of oral tissues to ultrasound.


The use of associates in private practice.


Use of epinephrine with local anesthesia in hypertensive patients. IV. Effect of tooth extraction on blood pressure and pulse rate.


The professional success standards of Alabama dentists.


Space nutrition.

Space nutrition.


Postoperative diet therapy.

Postoperative diet therapy.


Chemicals in foods.

Chemicals in foods.


Effect of low-calcium intake on phosphorus retention.


Adaptation to a low-calcium intake.

Adaptation to a low-calcium intake.


Supplementary relationships of proteins.


Bacterial growth in potato and turkey salads.


New method of calculating yield of recipes.


PANEL discussion on current aspects of diabetes in older persons.


Overeating and vascular degeneration: excesses causing insufficiencies.


The gradient elution chromatogram of the urinary neutral 17-ketosteroids in three cases of myxedema; a simplified method of combined continuous extraction and acid hydrolysis.


The use of aminoisometradine (rolicton) in the aged cardiac.


Group-centered corrective therapy as a motivational catalyst in a geriatric program.


Education in motor vehicle accident prevention.


Oral metrazol in the care of the aged; a review of twenty-eight cases.


Thrombopenic purpura as a complication of mumps.


Objectives for state medical society traffic safety committees.


Use of promethazine (phenergan) hydrochloride in obstetrics; report of a two and one-half year survey.


Influence of chlorothiazide on water and electrolyte excretion in preeclampsia.


Causes versus symptoms in automobile accidents.


Pathological findings in jaundice associated with iproniazid therapy.


Uses and abuses of the tissue committee.


Effect of air flow resistance on ventilation and respiratory muscle activity.


Manual and mechanical control of ventilation during cyclopropane anesthesia.


Factors to be considered in planning a rehabilitation service.


Cytometer chamber spermatocidal test; an improved technique for evaluating spermatocidal activity.


Clinical evaluation of the starch tolerance test.


Corneal complication of chloroquine (aralen) phosphate therapy.


Purpura due to chlorothiazide (diuril).

Purpura due to chlorothiazide (diuril).


Metabolic and biochemical changes in normal pregnancy.


HISTOPLASMOSIS.

HISTOPLASMOSIS.


Carcinoma of the thyroid in children after x-ray therapy in early childhood.


Promethazine hydrochloride in surgery and obstetrics.


Holistic approach to clinical problems of hypersensitivity.


Comparative effects of anesthetic agents on cardiac irritability during hypothermia.


Therapy of acute attacks of asthma in infants and children.


Management of chronic urticaria.

Management of chronic urticaria.


Dermographia; clinical observations.

Dermographia; clinical observations.


Clinical and metabolic study of chlorothiazide (diuril); use in edema of normal pregnancy and of toxemia of pregnancy.


Analysis of the precipitation test for systemic lupus erythematosus.


Evaluation of a new oral resuscitator for expired-air artificial ventilation.


Purpura fulminans treated successfully with anticoagulation; report of a case.


Vitamin preparations as dietary supplements and as therapeutic agents.


Study of staphylococcic infections occurring on a surgical service.


Treatment of hypertension with chlorothiazide.


Chlorothiazide (diuril): a new, nonmercurial, orally given diuretic.


Morphology and racial distribution of fatal coccidioidomycosis; report of a ten-year autopsy series in an endemic area.


Chlorothiazide and premenstrual tension.


Symptomatic hiatus hernia.

Symptomatic hiatus hernia.


Pruritus ani et vulvae.

Pruritus ani et vulvae.


Adverse reactions to sulfamethoxypyridazine (kynex); its use in the treatment of dermatitis herpetiformis.


Preservation of natural landmarks in unilateral cleft lip.


ERYTHREMIA (polycythemia vera), radiation therapy, and leukemia.


An improved vaginal applicator.

An improved vaginal applicator.


HOW OLD is too old to work.

HOW OLD is too old to work.


Cause of peptic ulcer.

Cause of peptic ulcer.


Atrial septal defect; results of surgical correction in one hundred patients.


Pregnancy in the patient with ileostomy and colectomy.


Problems in rehabilitation of the hemiplegic patient.


Studies in human isolation.

Studies in human isolation.


Effect of digitalis and diuretics on exertional dyspnea; study in ambulant patients with chronic heart disease.


Computers in medicine and biology.

Computers in medicine and biology.


Lactation inhibition by deladumone injected during labor or just after delivery.


Choriocarcinoma; report of a case of 25-year survival after orchiectomy.


Prevention of postpartum lactation by administration of deladumone during labor.


Enthesitis; traumatic disease of insertions.


FURAZOLIDONE: 3-(5-nitro-2-furfurylideneamino)-2-oxazolidinone.


THIOPROPAZATE hydrochloride: 2-chloro-10-[3-[4-(2-acetoxyethyl)-piperazinyl]-propyl]-phenothiazine dihydrochloride.


TRIAMCINOLONE: 9 alpha-fluoro-16 alpha-hydroxyprednisolone.


Simple, rapid diagnostic test for rheumatoid arthritis; bentonite flocculation test.


Bentonite flocculation test in rheumatoid arthritis.


Extrahepatic complications associated with cirrhosis of the liver.


Internal fixation of the fibula in fractures of both bones of the leg.


Upper arm block anesthesia in children with fractures.


The resident and medical student.

The resident and medical student.


Opacifing gallstones.

Opacifing gallstones.


Treatment of melanoma by isolation-perfusion technique.


Endotracheal tube as a source of infection.


Topical use of nitrofurazone (furacin) for bacterial dermatitides; effectiveness of therapy and incidence of hypersensitivity reactions.


The American Medical Association civil defense program.


The federal civil defense program; OCDM.


National medical preparedness.

National medical preparedness.


Chemical and biological warfare.

Chemical and biological warfare.


California CPX-medical and welfare services.


The story of Operation Prep Pitt; Pittsburgh's first disaster drill with simulated casualties.


General public health problems in civil defense.


American Medical Association special study project report.


Operation Star.

Operation Star.


Operation Afta.

Operation Afta.


The profession's civil defense responsibilities.


National shelter program.

National shelter program.


Resuscitation techniques.

Resuscitation techniques.


The roll of dentistry in civil defense.

The roll of dentistry in civil defense.


The civil defense role of nurses.

The civil defense role of nurses.


DISASTER medical care.

DISASTER medical care.


Practical approach to fluid therapy.

Practical approach to fluid therapy.


Peripheral vascular diseases of the geriatric group; a symposium.


Hemorrhage in the newborn with report of two cases.


Simplified subtotal gastrectomy.

Simplified subtotal gastrectomy.


The conservative approach to congenital orthopedic problems.


Subtotal cholecystectomy: its rationale, technic, and postoperative evaluation.


The treatment of verruca plantaris by cryotherapy.


Rupture of cesarean scar in gravid uterus with placenta previa and placenta accreta.


Testicular tumors: a report of recent cases.


Some new developments in public health programs.


A photometric determination of vitamin D in presence of vitamin A.


The effect of dimercaprol on amine oxidase and amino acid decarboxylase of the normotensive and hypertensive rat kidney.


Protective activity of some flavonoid materials against the acute toxicity of adrenergic compounds to rats.


Tablet color coating with pigments.

Tablet color coating with pigments.


Mono-derivatives of methylene citric acid.


The use of an approximate dielectric constant to blend solvent systems.


Pharmacology of some mono-derivatives of methylene citric acid.


An enteric compression coating. I. In vitro studies.


An enteric compression coating. II. In vivo studies with barium sulfatepotassium iodide and barium sulfate tablets.


An enteric compression coating. IV. Studies with acetylsalicylic acid (A.S.A.) tablets.


An enteric compression coating. III. In vivo studies with ilotycin tablets.


A study of the interaction between quaternary ammonium compounds and several certified dyes.


Sulfamethylthiadiazole: human blood concentration and urinary excretion data following oral doses.


The kinetics of the hydrolysis of homatropine.


Glutarimides. V. Synthesis of 2-allyl-2-phenylglutarimide.


Determination of the heat stability of medicinal white oils.


The occurrence of a free amino pool in cultures of Claviceps litoralis Kawatani.


A note on 3-thienyl-beta-di-alkylaminoethyl ketones and related compounds.


A note on particulate matter encountered in some dextran injections.


Investigation of stability in emulsions of varying viscosities.


Pentylenetetrazol seizure threshold in meprobamate- and phenaglycodol-treated mice.


Quantitative evaluation in vitro of oxytocics.


Derivatives of 8-hydroxy-2-quinoline acrylic acid.


A colorimetric assay for the determination of diethylstilbestrol.


The sterilization of polyethylene bags by electron irradiation and a bacterial monitor as a measure of sterility.


Study of the cation exchange properties of bentonite with application to the assay of pharmaceuticals.


A preliminary report of the effect of gastric mucous upon tablet disintegration.


Compression of crystalline substances.

Compression of crystalline substances.


A study of the gravimetric silicotungstate method of assay for thiamin.


The gravimetric silicotungstate method of assay for thiamin in the presence of interfering substances.


A study of the influence of gibberellic acid on the morphology, histology, and biosynthesis of the glycosides of first-year's growth of Digitalis purpurea L.


A phytochemical investigation of Rauwolfia decurva Hook.


A study of the influence of gibberellic acid on the growth of Fagopyrum esculentum Moench and the biosynthesis of rutin.


The antisecretory and antipeptic activity of gastric antacids in the histamine-stimulated rabbit.


Comparative rate of absorption of four commercial analgesic tablets.


Analogs of nucleotides. III. Synthesis in the series of adenosine phosphonate derivatives.


Studies on the inhalation of vapors from radioactive menthol and camphor.


The influence of gibberellic acid on the growth and alkaloid biogenesis in Datura stramonium Linné and in Atropa belladonna Linné.


Catalytic hydrogenation of derivatives of alpha-cyano-beta-(1-naphthyl) acrylic acid.


Antibacterial activity of the heartwood of Haematoxylon braziletto.


A note on condensation reactions of N-guanidino-p-benzoquinone imine hydrazine derivatives; the in vivo antibacterial activity of one derivative.


Negative galvanic current in the surgical correction of onychocryptotic nails.


New spray-on dressing useful in foot orthopedics.


Granuloma annulare; a case report.

Granuloma annulare; a case report.


An atypical case of gout; a case report.


The relative efficiency of the milk ring test and area blood tests for bovine brucellosis.


Surgical removal of canine heartworms by pulmonary arteriotomy.


Epidemiological studies on psittacosis in Allegheny county.


Use of spay hook in baby pig castration.


Fibrosarcoma of the urinary bladder in the dog.


Fibrous dysplasia of the bone in swine.

Fibrous dysplasia of the bone in swine.


Q fever in Iowa dairy cattle.

Q fever in Iowa dairy cattle.


A survey of human and veterinary medicine.


Hypertropine osteoarthropathy in a dog; a clinico-pathological report.


The formation of a functional osseous callus in the presence of avascular necrosis of the femur of a dog; a case report.


Promazine; its pharmacological and clinical effects in horses.


Promazine as a preanesthetic agent in horses.


Report on finger-electrode electroejaculator.


Dermoid cyst of the canine ovary.

Dermoid cyst of the canine ovary.


Field trials of infectious bovine rhinotracheitis vaccine.


Spina bifida with myelomeningocele in a calf.


Pseudomonas mastitis; a case report.

Pseudomonas mastitis; a case report.


Polycythemia rubra vera in the dog.

Polycythemia rubra vera in the dog.


Screening tests of some organic phosphorus, carbamate, and other compounds against Strongyloides stercoralis in the dog.


Osteosarcoma of the tibia and fibula of a dog.


A clinical and radiological study of canine bone neoplasms. I.


Rabies prophylaxis in cattle.

Rabies prophylaxis in cattle.


Embedded pin in the lung of a dog.

Embedded pin in the lung of a dog.


Removal of a hepatic abscess in a cat.

Removal of a hepatic abscess in a cat.


A ruminocolic fistula in a ewe.

A ruminocolic fistula in a ewe.


The ineffectiveness of hygromycin against gastrointestinal nematodes of sheep.


Comparison of infectious bovine rhinotracheitis, shipping fever, and calf diphtheria of cattle.


Survival of a guinea pig following infection with street rabies virus; a case report.


RABIES; postexposure treatment of animals.


Bacteriological studies on kanamycin. II. Inhibition of bactericidal effect of kanamycin by egg yolk.


Bacteriological studies on kanamycin. I. Antibacterial spectrum and one-way cross resistance of E. coli with streptomycin.


Further study on griseoflavin; identification with novobiocin.


Studies on antibiotics. XVII. Principal component of dextromycin, an antibiotic.


Clinical studies with dihydrodesoxystreptomycin; preliminary report.


Clinical and laboratory experiences with oleandomycin or triacetyloleandomycin in pediatric clinic.


Studies on chronic toxicity of kanamycin.


On antitumor effect of sarkomycin-INH.

On antitumor effect of sarkomycin-INH.


The metabolism of Streptomyces griseus. VI. The oxidation of the amino acid by the freezedried mycelium of Streptomyces griseus.


The metabolism of Streptomyces griseus. VII. The oxidation of L-glutamic acid by the intact mycelium.


Identity of latumcidin with abikoviromycin.


The diagnosis of gynecological tumors.

The diagnosis of gynecological tumors.


Radiation protection.

Radiation protection.


Advances in surgical treatment of congenital heart disease.


Pathology.

Pathology.


Patterns of interpersonal stress in childhood.


Wide Range investigations of acceleration in man and animals.


Some effects of acceleration on human subjects.


Effect of water immersion on human tolerance to forward and backward acceleration.


Comparison of drowsiness induced by bonamine and marezine.


Effects of positive acceleration upon the performance of an air-to-air tracking task.


Present status of aircraft liquid oxygen breathing systems.


Analysis of action of L-alanine analogues in spore germination.


Metabolic basis for disaccharide preference in a Cellvibrio.


Disaccharide preference of an aerobic cellulolytic bacterium, Cellvibrio gilvus n. sp.


Dissociation in Pasteurella pestis: immunological comparisons of smooth and non-smooth variants.


Studies in the physiology and biochemistry of penicillin-induced spheroplasts of Escherichia coli.


Dissociation in Pasteurella pestis: interrelations of smooth and nonsmooth variants.


Electron microscope survey of the surface configuration of spores of the genus Bacillus.


Differential effect of hog gastric mucin on properdin and host resistance to infection.


Polyphosphate accumulation and utilization as related to synchronized cell division of Corynebacterium diphtheriae.


Microbiological studies with thioctic acid analogues. I. Inhibitory effects of 6-ethyl-8-mercaptooctanoic acid and related thioctic acid analogues for growth of microorganisms.


Microbiological studies with thioctic acid analogues. II. Enzymatic evidence for interference with acetyl transfer by 6-ethyl-8-mercaptooctanoic acid.


Oxidative assimilation by Azotobacter agilis.


Detection of bacterial gelatinases by gelatin-agar plate methods.


Nucleic acid synthesis in penicillin-treated Alcaligenes faecalis.


Nucleic acid synthesis in ultraviolet-irradiated Bacillus cereus.


Simple method for separating leptospirae from contaminating microorganisms.


Hiatus hernia and disturbances of the function of the cardia in the practice of examining infants (with comments on the technique of examination).


Micro-radiographical investigation of the vascular pattern in the liver of rats.


To Rudolph J. Anderson.

To Rudolph J. Anderson.


The binding of glycogen and phosphorylase.


Lactose synthesis. IV. The synthesis of milk constituents after unilateral injection of glycerol-1,3-C14 into the pudic artery.


Studies on carbohydrate metabolism in rat liver slices. XIV. Metabolic alterations associated with dietary variation.


Lactose synthesis. V. C14 in lactose, glycerol, and serine as indicators of the triose phosphate isomerase reaction and pentose cycle.


Phosphorolytic cleavage of fructose-6-phosphate by fructose-6-phosphate phosphoketolase from Acetobacter xylinum.


The distribution of C14 in the hexose phosphates and the effect of recycling in the pentose cycle.


Glucose catabolism in fetal and adult heart.


The role of glycolic acid oxidase in the respiration of leaves.


Glucose and gluconate dissimilation in Acetobacter suboxydans.


The metabolism of the organic acids of tobacco leaves. XV. Effect of culture of excised leaves in solutions of potassium phosphate.


Biochemistry of the sphingolipides. XI. Structure of phytoglycolipide.


The enzymatic synthesis of sphingomyelin.


A reinvestigation of the cerebroside deposited in Gaucher's disease.


Three-phase countercurrent distribution: theory and application to the study of strandin.


Bile acids. XI. Structures of the isomeric 3 alpha, 6, 7-trihydroxycholanic acids.


Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite.


Separation of steroid sulfokinases.

Separation of steroid sulfokinases.


Arginine-vasotocin, a synthetic analogue of the posterior pituitary hormones containing the ring of oxytocin and the side chain of vasopressin.


The reversibility of inactivation of chymotrypsin.


On the cysteine content of human hemoglobin.


Cleavage of disulfide bonds in trypsinogen and alpha-chymotrypsinogen.


Amino acid sequence in the region of diisopropylphosphoryl binding in diisopropylphosphoryl-trypsin.


The electrophoresis and titration of fumarase.


Kinetics of papain action. III. Hydrolysis of benzoyl-L-arginine ethyl ester.


Active site of papain and covalent high-energy bonds of proteins.


Purification and properties of dihydro-orotic dehydrogenase.


Further studies on the fractionation of calf thymus histone.


The iron content of tobacco mosaic virus and some properties of its infectious nucleic acid.


Ultraviolet difference spectra of tyrosine groups in proteins and amino acids.


A complete ionization scheme for tyrosine, and the ionization constants of some tyrosine derivatives.


The specific binding of L-tryptophan to serum albumin.


Abnormal human serum globulins. II. Physical constants and amino end groups.


Fluorescence spectra and polarization of glyceraldehyde-3-phosphate and lactic dehydrogenase coenzyme complexes.


L-glutamic acid dehydrogenase. II. Role of enzyme sulfhydryl groups.


Exchange diffusion, transport, and intracellular level of amino acids in Ehrlich carcinoma cells.


Potassium migration and amino acid transport.


Non-exchange of carboxyl oxygen in mammalian amino acid transport.


Biosynthesis of urea. VII. Reversible formation of argininosuccinic acid.


The enzymatic synthesis of diaminopimelic acid.


Amino acid imbalance and nitrogen retention in adult rats.


Purine N-oxides. IV. Action of xanthine oxidase on adenine 1-N-oxide.


Purine N-oxides. III. Some biological activities of adenine 1-N-oxide derivatives.


Aspects of the stability of a bacterial ribonucleic acid.


An analysis of the acid-soluble fraction of normal and T2r-infected cells of Escherichia coli, strain B.


Enzymatic phosphorylation of deoxycytidylic acid.


The synthesis and function of luciferyl-adenylate and oxyluciferyl-adenylate.


Studies in vitro of digestion and absorption of pyrimidine nucleotides by the intestine.


Bacterial oxidation of vitamin B6. I. Isopyridoxal and 5-pyridoxic acid.


Bacterial oxidation of vitamin B6. II. Structure of 260 compound.


Carbamyl phosphate synthetase: studies on the mechanism of action.


Lipide components of the succinate and reduced diphosphopyridine nucleotide oxidase system.


On the mode of action of 2, 4-dinitrophenol in uncoupling oxidative phosphorylation.


Xanthine oxidase. IV. Participation of iron in internal electron transport.


Xanthine oxidase. III. Sulfite oxidation as an ultra sensitive assay.


The preparation of phosphorylating subfragments of rat liver mitochondria with digitonin.


The adenosine triphosphate-adenosine diphosphate exchange reaction of oxidative phosphorylation.


Synthesis of vinyl phosphate, a possible intermediate in carbohydrate metabolism and photosynthesis.


The purification and properties of yeast isocitric lyase.


Acetoacetate and glucose uptake by diaphragm and skeletal muscle from from control and diabetic rats.


Biosynthesis of estrogen by the perfused stallion testis.


Oxidation of albumin-bound palmitate-1-C14 by adipose and hepatic tissues of the rat.


The incorporation of C14-acetate into the lipides on tissues undergoing cell division.


The isolation, characterization, and measurement of steroid glucuronides in human plasma.


The metabolism of acetone-2-C14 by intact rats.


Studies in vitamin E deficiency. IV. The influence of steroid hormones on rabbit skeletal muscle.


Studies on copper metabolism. XXVII. The isolation and properties of an erythrocyte cuproprotein (erythrocuprein).


Some chemical and physical properties of erythrocuprein.


Glutamic aspartic transaminase. I. Assay, purification, and general properties.


Two tripeptides from an enzymatic digest of collagen.


The thrombin-induced formation of co-fibrin. II. Preliminary amino acid sequence studies on peptides A and B.


Thrombin-induced formation of co-fibrin. I. Isolation, purification, and characterization of co-fibrin.


Reduction of insulin by extracts of rat liver.


Incorporation of hydroxyproline into tissue proteins by chick embryos.


Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues.


Lack of tryptophan-niacin relationship in corn and tobacco.


Enzymatic cleavage of S-adenosylmethionine.


The metabolism of DL-tryptophan-alpha-C14 by the rat.


The accumulation of acetylmethylcarbinol and acetylethylcarbinol by a mutant of Neurospora crassa and its significance in the biosynthesis of isoleucine and valine.


Metabolism of phosphoserine. I. Exchange of L-serine with phosphoserine.


The relation of ascorbic acid to the conversion of proline to hydroxyproline in the synthesis of collagen in the carrageenan granuloma.


Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase.


At 5'-nucleotidase activated by ferrous iron.


The ability of purine and thymine derivatives and of glycine to support the growth of mammalian cells in culture.


Effect of pyridine derivatives on animal tissue diphosphopyridine nucleotidases.


The effects of salicylate on the metabolism of acetate in the rat.


Side chain oxidation of alkyl substituted ring compounds. I. Enzymatic oxidation of p-nitrotoluene.


Antithyroid action of 3-amino-1,2,4-triazole.


The bacterial oxidation of nicotine. I. Nicotine oxidation by cell-free preparations.


The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine.


Purification of an enzyme from yeast which liberates protein-bound thioctic acid.


Studies of tissue permeability. IV. The distribution of glucose between plasma and muscle.


Studies of tissue permeability. V. The penetration and phosphorylation of 2-deoxyglucose in the rat diaphragm.


alpha-Ketoglutaric dehydrogenase. VI. Reversible oxidation of dihydrothioctamide by diphosphopyridine nucleotide.


alpha-Ketoglutaric dehydrogenase. VII. The role of thioctic acid.


The effect of temperature on the oxidation-reduction potential of the diphosphopyridine nucleotide system.


An effect of vitamin E on the regulation of succinate oxidation in rat liver mitochondria.


A biochemical mechanism for the depression in hepatic acetate oxidation in fasted, cold-exposed rats.


Studies on the inhibitory effect of intestinal mucosa of succinoxidase activity.


The biosynthesis of salicyl glucuronides by tissue slices of various organs.


The luminescence camera.

The luminescence camera.


Colpophotography.

Colpophotography.


LogEtronics.

LogEtronics.


A simplified system for gross photography, x-ray and other copy.


A water immersion technique for producing high detail radiographs of laboratory animals.


Electron microscope studies of the human epidermis: the clear cell of Masson (dendritic cell or melanocyte). The human epidermis has been studied by electron microscopy following osmium tetroxide and potassium permanganate fixation. An anatomically distinct cell in the human epidermis has been demonstrated with features similar to the melanocyte of the hair bulb described by Barnicot, Birbeck and Cuckow (3). It is dendritic in form and does not contain tonofilaments. "Intercellular bridges" are not formed. The mitochondria are larger and more numerous than those of other epidermal cells and the endoplasmic reticulum is more complex. Some of these cells contain melanin but others are melanin-free. The cell has been interpreted as being identical with the dopa-positive, clear cell of Masson (dendritic cell of Bloch or melanocyte). We have found that many membranous structures in the human epidermis are better preserved by permanganate fixation than by osmium tetroxide fixation.


Electron microscope study of DNA-containing plasms. II. Vegetative and mature phage DNA as compared with normal bacterial nucleoids in different physiological states. The nucleoids of Escherichia coli, independently of the physiological state of the bacteria, are shown to be preserved as a fine-stranded fibrillar nucleoplasm by an OsO(4) fixation under defined conditions: acetate-veronal buffer pH 6, presence of Ca(++) and amino acids, stabilization with uranyl-acetate before dehydration. The same fixation procedure applied to the DNA of vegetative phage reveals a pool of homogeneous fibrillar structure very similar to the nucleoplasm. The "versene test," which produces a coarse coagulation of these plasms, emphasizes the similar behaviour of the pool and the nucleoids. The heads of mature phage are preserved in their true polyhedral shape by the standard fixation procedure, although they may be badly distorted when fixed under different conditions. Lanthanum nitrate and uranyl-acetate are shown to increase markedly the contrast of both phage and cytoplasm. The consequences of the fibrillar structure of the genetic material are discussed in relation to the probable division process.


The fine structure of brown adipose tissue in the newborn mouse and rat. Interscapular fat from newborn rats and mice was fixed in buffered 1 per cent osmium tetroxide and thin sections of the methacrylate-embedded tissue were studied with the electron microscope. The findings have reaffirmed the epithelioid character of brown adipose tissue, and have provided additional information on the relation of its cells to each other and to the rich capillary bed. For the most part, the earlier description of the fine structure of brown adipose cells by Lever, has been confirmed, but our observations on the mitochondria and their relation to fat droplets have led us to different conclusions concerning the role of these organelles in lipogenesis. Mitochondria were often found to be very closely associated with lipide inclusions, but no actual communication between the two was observed and no evidence was found to support the hypothesis that mitochondria are transformed into lipide droplets. Large dense bodies which showed a highly ordered fine structure suggesting a crystalline protein were seen in the matrix of some mitochondria. The cytoplasm of the adipose cells contained fine granules that seemed to be of two kinds: particles of uniform size ( approximately 150 A) and appreciable density that are believed to be ribonucleoprotein, and granules of lower density and more variable size that are tentatively interpreted as a form of glycogen. The Golgi complex of the adipose cells was small and the endoplasmic reticulum almost entirely absent. The significance of the poor development of these organelles is discussed in relation to current concepts of their function.


The effect of HCl hydrolysis on the retention of thymidine in DNA. Allium roots grown in C(14)-thymidine and H(3)-thymidine media were treated with N hydrochloric acid at 60 degrees C. as in standard Feulgen hydrolysis. The retention of the radioactive thymidine in DNA as a function of hydrolysis time was studied autoradiographically. No significant loss of label was detected until hydrolysis was extended beyond the optimal time for Feulgen staining. The data are consistent with the assumption that there is no significant loss of DNA during normal Feulgen hydrolysis in the material used.


The ultrastructure of mouse lung: the alveolar macrophage. Free alveolar macrophages of normal mouse lung have been studied in the electron microscope. The tissue was obtained from several young adult white mice. One other animal was instilled intranasally with diluted India ink 1(1/2) hours prior to the removal of the lung. Thin sections of the osmium-fixed, methacrylate-embedded tissue were examined either in an RCA EMU 2 electron microscope or in a Siemens and Halske Elmiskop I b. A few thick sections obtained from the same embeddings were stained for iron. The normal alveolar macrophages, which are usually in contact with the alveolar epithelium, were found to contain a variety of inclusion bodies, along with the usual cytoplasmic components like mitochondria, endoplasmic reticulum, and Palade granules. Another typical component of the cytoplasm of these cells which appears as small ( approximately 6 mmicro) very dense granules of composite fine structure is interpreted as ferritin. It is assumed that this ferritin is formed from red blood cells ingested by the alveolar macrophages. The macrophages in the alveoli were found to phagocytize intranasally instilled India ink particles. Such cells, with engulfed India ink particles, were often of more rounded form and the particles were frequently seen lying inside membrane-bound vacuoles or vesicles of the cytoplasm. The membrane of a few vesicles containing India ink particles was seen as the invaginated portion of the cell plasma membrane, and in one instance these same vesicles were seemingly interconnected with a rough surfaced cisterna of the endoplasmic reticulum. The process of phagocytosis is recognized as related to the "normal" process of pinocytosis.


A comparison of scanning and two-wavelength microspectrophotometry. Because of the absence of suitable standards, microspectrophotometry suffers from a lack of objective verification. An approach to this problem is suggested which is based on the comparison of results obtained when different techniques or instruments are applied to the same objects. The application of this approach to scanning versus two-wavelength photometry has been justified by the widely different bases of these two methods. A group of ascites tumor cells stained with gallocyanin-chrome alum was measured successively with both methods and a high degree of proportionality between the two sets of results was found. This suggests that the two methods measure the same quality of the cells within a standard deviation of 3.39 per cent. This degree of correlation is a verification of the accuracy of both of the methods and shows that either one is suitable for resolving differences in stain content between cell nuclei of the order of 10 per cent.


Adenosinetriphosphatase and 5-nucleotidase activities in the plasma membrane of liver cells as revealed by electron microscopy. The sites of reaction product resulting from ATPase and 5-nucleotidase activities remaining in parenchymatous cells of osmium-fixed rat liver were studied by electron microscopy of thin sections. These indicate that both ATPase and 5-nucleotidase activities are localized in the plasma membrane where it folds to form the microvilli of the bile canaliculus, and that 5-nucleotidase activity is also present in the microvilli at the sinusoidal aspects of the cells. It is suggested that these enzymes, particularly ATPase, may play a role in molecular transport or in some kind of membrane activity at the cell surface. Of special interest is the apparent differential localization of these enzymes at the absorptive and secretory regions of the plasma membrane of the cell. It may be of interest to study changes in these enzyme localizations in pathologic states, as a sign of changed cell function. Some of the difficulties in the interpretation of enzyme reaction products seen in electron micrographs are discussed.


Calf thymus composition: a comparison of differential centrifugation and chemical fractionation procedures. The extraction behavior of thymus and the composition of fractions prepared from this organ has been studied. Sequential extraction methods using 0.15 M NaCl followed by water gave information with respect to the weight fraction of cytoplasmic and nuclear constituents. Lipide, nucleic acid, and electrophoretic analysis of the extracts provided additional information. A less complex electrophoretic pattern was obtained from subsequent extracts in the sequence. Sucrose and saline dispersates obtained from tissue fragmented with either the Potter-Elvehjem homogenizer or in a Waring blendor were fractionated, using standard differential sedimentation methods. The fractions obtained by means of four different dispersion procedures were compared in terms of yield, chemical analysis, and electrophoretic composition. The quantity of material in thymus having the sedimentation characteristics of liver mitochondrial and microsomal fractions was remarkably small. Both the suspension medium employed and the method used to bring about a disruption of the cells in the tissue affected the yield of "particulate" material. The components present in the later extracts in the sequence, E(4) to E(7), in the case of sequential extraction study resembled with respect to chemical composition and electrophoretic characteristics, the microsome fraction prepared by differential sedimentation methods. About 76 per cent of the PNA in the tissue appeared to be in the cytoplasm. The remaining 24 per cent PNA was found in the nucleus and accounted for 1.7 per cent of nucleus on a dry weight basis. From 75 to 88 per cent of cytoplasmic PNA was extracted from the tissue and 76 to 94 per cent of the PNA in the extract was found in the final supernatant solutions, depending upon the dispersion methods and suspension medium used in the extraction procedure. The composition of the final supernatant fractions using differential sedimentation methods were comparable in terms of electrophoretic properties, protein concentration, nucleic acid content, and fractionation behavior to saline extracts E(1) to E(3), of thymus used in earlier studies.


The fine structure of nerve cells and fibers, neuroglia, and sheaths of the ganglion chain in the cockroach (Periplaneta americana). The abdominal nerve cord of Periplaneta americana was studied utilizing light and electron microscopes. In the nerve cells, delicate granules, similar to those probably responsible for cytoplasmic basophilia, are evenly distributed in "dark" cells and clumped in "light" cells. Neuroglial cells are stained metachromatically by cresyl violet. The neuroglial cells have many processes which ramify extensively and are enmeshed to form overlapping layers. These imbricated processes ensheath the nerve cells; the inner layer of the sheath penetrates into the neuron and is responsible for the appearance of the trophospongium of Holmgren. Nerve fibers are embedded within glial cells and surrounded by extensions of the plasma membrane similar to mesaxons. Depending on their size, two or several nerve fibers may share a single glial cell. Nerve fibers near their terminations on other nerve fibers contain particles and numerous, large mitochondria. The ganglion is ensheathed by a thick feltwork of connective tissue and perilemmal cells. The abdominal connective has a thinner connective tissue sheath which is without perilemmal cells. The nerve fibers and sheaths in the connective become thinner as they pass through ganglia.


Staining of tissue sections for electron microscopy with heavy metals. II. Application of solutions containing lead and barium. Descriptions of three heavy metal stains and methods of application to tissue sections for electron microscopy are presented. Lead hydroxide stains rather selectively two types of particles in liver: those associated with the endoplasmic reticulum and containing ribonucleic acid and other somewhat larger particles. Barium hydroxide emphasizes certain bodies within vesicles of the Golgi region of hepatic cells. Alkalized lead acetate is useful as a general stain, as are also lead and barium hydroxides.


Submicroscopic organization of retinal cones of the rabbit. The fine structure of the cone cell of the rabbit is described and compared wtih that of the rod. The cone outer segment consists of a pile of flattened sacs with two membranes 30 A thick and a regular clear space in between of about 30 A. The membrane of the rod sacs is slightly thicker ( approximately 40 A) and the clear space is less regular and frequently absent in the deeper regions. The distance between sacs is from 85 to 95 A in the cone and from 110 to 120 A in the rod, and the total repeating period is about 190 A and 210 A, respectively. These results are discussed in relation to the concentration of solids in both photoreceptors. A connecting cilium was observed in the cone cell and compared with that previously described in rods (4). This finding suggests that morphogenetically the cone may also result of the differentiation of a primitive cilium (5). The inner segment of the cone shows a distal portion with large concentration of elongated mitochondria and a proximal one with a large Golgi complex in the axis surrounded by components of the endoplasmic reticulum. It is concluded that both photoreceptors have a similar general plan of submicroscopic organization, with some minor difference in fine structure probably related to their specific chemical composition and function.


The cytochemical localization of oxidative enzymes. I. Diphosphopyridine nucleotide diaphorase and triphosphopyridine nucleotide diaphorase. Cytochemical methods involving metal chelation of the formazan of an N-thiazol-2-yl tetrazolium salt are described for the localization of diphosphopyridine nucleotide diaphorase (DPND) and triphosphopyridine nucleotide diaphorase (TPND) in mitochondria. These methods utilize the reduced coenzymes DPNH or TPNH as substrate. The reaction involves a direct transfer of electrons from reduced coenzyme to the respective diaphorase which in turn transfers the electrons to tetrazolium salt, reducing it to the insoluble formazan. Competition for electrons by preferential acceptors in the respiratory chain was prevented by various inhibitors. In the presence of respiratory inhibitors the rate of tetrazolium reduction was markedly increased. The greatest reduction was observed when amytal was used. Sites of diaphorase activity appeared as deposits of blue-black metal formazan chelate measuring 0.2 to 0.3 micro in diameter. Small mitochondria contained 2 deposits, while larger ones contained up to 6. Considerable differences were observed in the rate of tetrazolium reduction and cellular localization of diaphorase activity when DPNH was used as substrate as compared to TPNH. In each instance DPNH was oxidized more rapidly by tissues than TPNH. These findings support the concept that the oxidation of coenzymes I and II is mediated through separate diaphorases.


The cytochemical localization of oxidative enzymes. II. Pyridine nucleotide-linked dehydrogenases. Methods are presented for the intramitochondrial localization of various diphosphopyridine nucleotide and triphosphopyridine nucleotide-linked dehydrogenases in tissue sections. The cytochemical reactions studied involve the oxidation of the substrates by a specific pyridino-protein. The electron transfer of tetrazolium salt is mediated by the diaphorase system associated with the dehydrogenase. The final electron acceptor was either p-nitrophenyl substituted ditetrazole (nitro-BT) or N-thiazol-2-yl monotetrazole (MTT), the latter giving rise to metal formazan in the presence of cobaltous ions. Mitochondrial localization of the formazan precipitate could be achieved by using hypertonic incubating media containing high concentrations of substrate and co-enzyme. A fast reduction of tetrazolium salt was obtained by chemically blocking the respiratory chain enzymes beyond the flavoproteins. Although diaphorase systems are implicated in the reduction of tetrazolium salts, specific dehydrogenases are solely responsible for the distinct distribution pattern obtained in tissues with various substrates. The present findings in tissue sections are discussed in conjunction with existing biochemical evidence from differential centrifugation experiments.


A cellophane-strip technique for culturing tissue in multipurpose culture chambers. A new technique for the cultivation of living tissues in the multipurpose culture chamber is described. This procedure employs strips of cellophane as the agent for anchoring tissue explants to the coverslip walls of the chamber and disposes of the time-honored plasma-clot technique. The primary advance embodied in this procedure lies in the fact that cells emigrating from so-cultured explants manifest themselves in a highly differentiated manner comparable to the cells of origin, whereas the outgrowth from the same types of tissue in plasma clots results in a more undifferentiated type of growth. Comparisons of outgrowths from embryonic thyroid, bone, and muscle (chicken) are photographically documented, and attention is called to certain cytochemical methods which further corroborate the differentiated quality obtained with the cellophane-strip technique.


Adenosinetriphosphatase activity in the cell membranes of kidney tubule cells. This cytochemical study demonstrates high levels of apparent ATPase activity in the infolded cell membranes of the proximal tubules (dog, rat, human, mouse, monkey, and opossum) and ascending loops of Henle (dog, rat, human and, to a variable degree, mouse). Electron microscopy has shown (see Rhodin (1)) that these membranes separate adjacent cells where they interlock with one another by multiple cytoplasmic lamellae containing oriented mitochondria. The significance of the high ATPase activity is considered in relation to possible movements of the membranes and to "active transport" believed to occur there. In the rat, enzyme activity in the proximal tubule membranes does not survive formol-calcium fixation, and it is therefore necessary to use unfixed sections for its demonstration. However, in edematous rats with experimental nephrosis (induced by the injection of aminonucleoside or with antikidney serum) marked ATPase activity is exhibited in these membranes even after formol-calcium fixation. When proximal tubule or Henle loop cells of the dog acquire an altered metabolism, as indicated by accumulated lipide spheres or by "droplets," the infolded ATPase-rich membranes are no longer demonstrable.


Structure and mode of formation of the nucleolus in meristematic cells of Vicia faba and Allium cepa. Interphase nucleoli from Vicia faba and Allium cepa meristematic cells are roughly classified into two categories: (a) those that commonly show a rather homogeneous texture (except for small light spaces of various sizes) and frequently contain dense particles 140 A in diameter; (b) those found more frequently in Vicia characterized by a very sharp boundary between a dense outer cortex and a much lighter central core. The dense particles are not found in such nucleoli. In Allium the boundary is more irregular and dense particles are sometimes observed in the outer layer. Many nucleoli show a structure intermediate between these two types. They are characterized by a gradient of increasing density from the center to the periphery and occasionally contain dense 140 A granules. During interphase, certain nucleoli are closely associated with segments of chromatin strands which undoubtedly represent nucleolar organizing regions. The dense 140 A granules are followed during the mitotic cycle. In Allium, they are first seen in loose clusters between arms of late anaphase chromosomes where they become more concentrated in early telophase. The substance within which they are scattered slowly increases in density during that time until finally, the particles are limited to small bodies of distinctive character. Evidence is presented suggesting that these small prenucleolar bodies fuse during telophase to give rise to the mature interphase nucleoli. Similar events are described in Vicia material except that a coating of dense substance appears around telophase chromosomes before the formation of prenucleolar bodies.


The influence of age, sex, pregnancy, starvation, and other factors on the cytoplasmic ribonucleoproteins of rat liver. Rat liver was homogenized in 0.88 M sucrose. The DNA and total RNA were determined, and the homogenate was fractionated by differential centrifugation. The pellets obtained between 30 minutes at 20,000 g and 180 minutes at 105,000 g were analyzed for RNA and nitrogen. The ribonucleoproteins were determined in the analytical ultracentrifuge. The non-pellet RNA was calculated by difference. The results are reported as amounts per 6.7 x 10(-9) mg. of DNA. In young, growing male rats the amounts of microsomal protein and ribonucleoprotein B (83S) increased with age. Non-pregnant adult females showed less non-pellet RNA and much more ribonucleoprotein C (63S) than did adult males. During pregnancy both of these cell constituents reverted to levels characteristic for male animals. Starvation for 5 days resulted in a reduction in the mass of liver tissue, the non-pellet RNA, the microsomal protein, and ribonucleoproteins B and C. During recovery from starvation the return of the liver to normal paralleled the rate at which body weight was restored. Treatment with cortisone, 25 mg. per rat per day for 5 days, caused an increase in microsomal protein and a decrease in ribonucleoprotein B. Treatment with 6-mercapto-purine, 50 mg. per kilo per day for 5 days, caused little change in liver composition in either males or females.


A cytological analysis of the antimetabolite activity of 5-hydroxyuracil in Vicia faba roots. The effects of 5-hydroxyuracil (5-HU) (isobarbituric acid) upon cell elongation, mitosis, and DNA synthesis were studied in Vicia faba roots. 5-HU had no consistent effect upon root elongation. It blocked DNA synthesis (analyzed by photometric measurements of Feulgen dye in nuclei) during the first 6 hours of treatment; the block spontaneously disappeared by the 12th hour of treatment. Uracil and thymine had no effect upon this block of synthesis. Both thymidine and uridine reversed the block in 6 and 9 hours respectively. In all cases blockage of DNA synthesis was followed by inhibition of mitosis (determined by changes in the percentage of cells in mitosis) and resumption of DNA synthesis was followed by resumption of mitosis. Inhibition indices calculated from the mitotic data indicated a competitive relationship between 5-HU and thymidine and 5-HU and uridine. 5-HU is considered to block DNA synthesis by competing with thymidine for sites on enzymes involved in the synthesis. It is suggested that uridine reverses the block in synthesis by undergoing a conversion to thymidine.


Pathological cytology of tobacco leaf infected with tobacco mosaic virus III.


Fine structure and function in Stentor polymorphous. The fine structure of the ciliate Stentor has been studied by means of the electron microscope and the results have been correlated with observations made on the living organism by means of light microscopy; special reference has been made to structural features which may be responsible for contraction and extension in Stentor. Descriptions have been given of the structure of the macronucleus, the vacuolated cytoplasm, mitochondria and the pellicle; a detailed study has also been made of the adoral membranelles. About 250 membranelles encircle the peristomal cap and each is composed of 3 rows of cilia, with 20 to 25 cilia in each row; a fibrillar root system connected with the membranelles depends into the endoplasm for about 20 micro and each is essentially in the shape of a fan, the terminal ends of each root bifurcating to connect to neighbouring roots. The membranelles thus form a cohesive unit and this morphological arrangement may have a bearing on the motion and coordination of the whole system. Two structural features extending throughout the length of the animal have been identified per cortical stripe in the body wall of Stentor; first, km fibres lying just beneath the pellicle are composed of stacks of fibrillar sheets and are identical with the birefringent fibres observed in the living animal. The individual fibrils of the sheets are in turn connected to the kinetosomes of the body cilia; thus the km fibres are homologous to kinetodesmata. Secondly, M bands lie beneath the km fibres and form an interconnected system in contact with the surrounding vacuolated cytoplasm; the thickness of the M bands is greatest at the base of a contracted animal. The contractile and extensile properties of these organelles have been discussed in the light of experimental results and theoretical considerations.


An autoradiographic study of nucleic acid and protein turnover in the mammalian neuraxis. The turnover of nucleic acids and proteins in the central nervous system has been explored by autoradiography following the subarachnoid injection of tagged precursors. Nuclear PNA of neurons and oligodendrocytes becomes radioactive earlier than cytoplasmic PNA after injection of adenine-C(14) and orotic-C(14) acid. By 24 hours following injection, cytoplasmic PNA is radioactive. Radioactivity persists with little decrease for as long as 51 days after an injection of adenine-C(14). The cells of the ependymal lining, choroidal plexus, leptomeninges, blood vessel walls, and Schwann cells also exhibit radioactivity in PNA as judged by the loss of radioactivity following ribonuclease digestion. From the 3rd day on, increasing numbers of the aforementioned cells, with the exception of nerve cells, exhibit ribonuclease-resistant nuclear radioactivity which is abolished by deoxyribonuclease. This radioactivity indicates labelling of nuclear DNA. Following the intrathecal injection of methionine-S(35) and glycine-2-H(3), nerve cells, oligodendrocytes, cells of ependymal lining, choroidal plexus, leptomeninges, blood vessels, and Schwann cells become radioactive. Nerve cells lose most of their radioactivity within a few hours, first from the cytoplasm and later from the nucleus. Other cell types retain their radioactivity for considerable periods of time. Although astrocytes, microglia, and satellite cells of sensory ganglia do not appear to incorporate labelled precursors into nucleic acids or proteins, reacting phagocytic microglia actively take up labelled amino acids. These results are discussed with particular reference to PNA and protein turnover in nerve cells, oligodendrocytes, and Schwann cells. It is believed that these metabolic activities in neurons are concerned in part with the elaboration of axoplasmic proteins. The nucleoprotein metabolism of oligodendrocytes and Schwann cells may be related to myelin biosynthesis both in the immature and the mature nervous system.


Distribution of hydrolases among anterior pituitary cell fractions (anterior pituitary hydrolases).


Retinal structure: moilusc cephalopods: Octopus, Sepia.


The fine structure of the pellicle in the contact area of conjugating Tetrahymena pyriformis.


Silver impregnation for electron microscopy.


Incorporation of thymidine in the cytoplasm of Amoeba proteus.


Dr. William A. Rogers and The Journal.

Dr. William A. Rogers and The Journal.


Injuries to flexor tendons of the hand in children.


Rheumatoid, tenosynovitis; diagnosis and treatment.


Tenosynovial osteochondroma in the hand.


Delayed advancement in the repair of lacerated flexor profundus tendons.


Congenital pseudarthrosis of the tibia.

Congenital pseudarthrosis of the tibia.


Vascular injuries in the orthopaedic patient.


Patellectomy; repair of the extensor mechanism.


Arthrogryposis multiplex congenita.

Arthrogryposis multiplex congenita.


Treatment by bone-grafting of aseptic necrosis of the femoral head and non-union of the femoral neck (Phemister technique).


The dashboard femoral fracture; pathomechanics, treatment, and prevention.


Early juxtacortical osteosarcoma (parosteal osteoma).


The correction of equinus deformity in cerebral palsy.


Brucellosis myelopathy.

Brucellosis myelopathy.


Cineplasty; historical review, present status, and critical evaluation of sixty-four patients.


Sciatica and the intervertebral disc; an experimental study.


Traumatic anterior dislocation of the hip in children.


Paget's disease of the patella.

Paget's disease of the patella.


Median-nerve compression at the wrist.

Median-nerve compression at the wrist.


Forty years on.

Forty years on.


Paralytic claw hand; with special reference to paralysis in leprosy and treatment by the sublimis transfer of Stiles and Bunnell.


A study of the end-results of compression arthrodesis of the knee.


The value of intra-articular injections in osteoarthritis of the knee.


Transposition of gluteus maximus, tensor fasciae latae and ilio-tibial band for paralysis of lateral abdominal muscles in children after poliomyelitis; a preliminary report.


The management of pathological fracture of the major long bones from metastatic cancer.


Postero-lateral dislocation of the knee with capsular interposition.


Hallux rigidus in the adolescent.

Hallux rigidus in the adolescent.


Familial joint laxity and recurrent dislocation of the patella.


Correction of the pronated foot.

Correction of the pronated foot.


Trochanteric fractures of the femur treated by the Vitallium McLaughlin nail and plate.


Treatment of pertrochanteric and basal fractures of the femur by immediate fixation with a two-piece nail and plate; a review of 100 consecutive cases.


The etiology of hyperostosis cranii (metabolic craniopathy); a clinical study.


Parosteal osteogenic sarcoma of bone; report of a case.


Bone sarcoma in Paget's disease; report of a case with long survival.


An apparatus for use in nailing of the femoral neck.


Long survival after amputation for Paget's sarcoma of bone.


The restoration of articular surfaces after joint excision; an experimental study with cartilage implants.


The ossification and vascularisation of the tarsal navicular and their relation to Köhler's disease.


The mechanical problem of the artificial hip.


Structural changes in bone associated with metallic implants.


Bonding of fractures by plastic adhesives; preliminary report.


DENIS JOSEPH GLISSAN; 1889-1958.

DENIS JOSEPH GLISSAN; 1889-1958.


CARLO PAIS; 1910-1958.

CARLO PAIS; 1910-1958.


[Heart-lung apparatus with the artificial pulmonary membrane of J. André Thomas].


Faith and healing.

Faith and healing.


The Christian influence of mission hospitals.


Osteomyelitis of the jaws and its treatment.


Recent advances in the radiology of the intestinal tract.


A preliminary report on a new approach to tetanus prophylaxis.


Faith healing.

Faith healing.


Acute complete prolapse of rectum in a young adult male.


Social processes in physicians' adoption of a new drug.


Dimensions of being modern in medical practice.


Survival rate of patients hospitalized with the diagnosis of general paresis.


MULTIDISCIPLINARY studies of illness in aged persons. II. A new classification of functional status in activities of daily living.


Some changes in the sleeping and eating patterns of fifty patients with long-term illnesses.


Tracemetals.

Tracemetals.


Studies in man on testicular and adrenal response to adrenocorticotropin and human chorionic gonadotropin.


Clinical effect of human pituitary follicle-stimulating hormone (FSH).


Familial true hermaphrodism in pre- and postpuberal genetic females; hormonal and morphologic studies.


Seminiferous tubule dysgenesis (Klinefelter's syndrome) in identical twins.


Cytology of human urinary sediment: diagnostic value of the non-nucleated cell.


Virilizing adrenal adenoma associated with increased urinary excretion of estrogens and 17-ketosteroids; isolation of steroids from the tumor.


Urinary excretion by man of 11 beta, 17 alpha, 20 alpha, 21-tetrahydroxy-4-pregnen-3-one and the 20 beta epimer.


Fractionated plasma protein values in subacute thyroiditis.


Simplified water loading test in hypoadrenocorticism and hypothyroidism.


The effect of insulin on serum lipoproteins of diabetic patients.


COLLABORATIVE assays of two local standards for human pituitary gonadotropin.


Determination of sex chromatin in the polymorphonuclear neutrophils of enriched smears.


Spontaneous formation of fern-leaf patterns in human saliva.


Oral releasin in dysmenorrhea.

Oral releasin in dysmenorrhea.


Resin uptake of radiothyroxine in sera from non-pregnant and pregnant women.


Plasma corticosteroid levels in aircrewmen after long flights.


The pathogenesis of hypochloremia in respiratory acidosis.


The effect of alloxan diabetes and acidosis on the mineral and water content of bone.


Susceptibility of rats with hormonal hypertension to experimental pyelonephritis.


Factors influencing respiration during heavy exercise.


The effect of hypercalcemia induced by calciferol upon renal concentrating ability.


The levels of individual free amino acids in the plasma of normal man at various intervals after a high-protein meal.


The passage of ammonia across the blood-brain-barrier and its relation to blood pH.


The interaction of human erythrocytes with sodium palmitate.


Serum protein changes in thermal trauma. I. Electrophoretic analysis at pH 8.6.


Acute effects of breathing inert dust particles and of carbachol aerosol on the mechanical characteristics of the lungs in man; changes in response after inhaling sympathomimetic aerosols.


Fetomaternal leukocyte incompatibility.

Fetomaternal leukocyte incompatibility.


Serial studies of renal function during pregnancy and the puerperium in normal women.


Partition of unesterified fatty acids in normal and nephrotic syndrome serum and its effect on serum electrophoretic pattern.


Increased aldosterone secretion following acute constriction of the inferior vena cava.


Comparative studies on adrenal cortical function and cortisol metabolism in healthy adults and in patients with shock due to infection.


Mechanisms of impaired water excretion in adrenal and pituitary insufficiency. I. The role of altered glomerular filtration rate and solute excretion.


Mechanism of release of ferritin iron in vivo by xanthine oxidase.


The management of uremia by perfusion of an isolated jejunal segment: with observations of the dynamics of water and electrolyte exchange in the human jejunum.


Structured measurement of personality and motivation: a review of contributions of Raymond B. Cattell.


Measurement of hepatic blood flow by indicator dilution techniques.


Platelet phosphatides: their separation, identification, and clotting activity.


Judgments of outcome of home care placement from psychological material.


Eight item clusters for use with the M-B History Record.


A factor analytically derived scale for rating activities of psychiatric patients.


Reliability of the HAS as a function of length of observation and level of adjustment.


Objective scoring vs. clinical evaluation of the Bender-Gestalt.


The influence of stress of MMPI scale scores.


The content of the MMPI.

The content of the MMPI.


A comparison of two MMPI measures of masculinity-femininity.


Time score as a criterion measure on the Taylor Manifest Anxiety Scale.


Relationship between measures of anxiety and constriction.


An MMPI scale measuring severity of psychopathology.


The effect of formal art training upon the quantitative scores of the H-T-P.


Responses of kindergarten children to the Children's Apperception Test.


Intelligence as a determinant of Rorschach card rejection.


A note on the order of figure drawing among incarcerated alcoholics.


Reliability of the Columbia Mental Maturity Scale with kindergarten pupils.


On the adequacy of the Krout and Tabin Personal Preference Scale standardization group.


Correlation between the Ohio Literacy Test, grade achieved in school, and Wechsler Bellevue IQ.


Comparison of the alternate Wechsler Memory Scale forms.


A comparison of the performance of bilingual and monolingual native born Jewish preschool children of traditional parentage on four intelligence tests.


Aphasic cerebral palsied children's wrong answers on Raven's Progressive Matrices.


A note concerning the intelligence of delinquents.


Structuring eclectic psychotherapy for the client.


A clinical evaluation of the method of direct analysis in the treatment of psychosis.


Some child therapy practices.

Some child therapy practices.


Effect of two phenothiazine drugs on concentrative attention span of chronic schizophrenics.


Incentive, time conception and self control in a group of emotionally disturbed boys.


Experimental control of dependency by posthypnotic suggestion.


The development and structure of the cephalic nerves in Nereis.


Degeneration of caudal medial geniculate body following cortical lesion ventral to auditory area II in the cat.


Descending connections to the lateral reticular nucleus; an experimental study in the cat.


A unitary study of the reticulomotor system of the dogfish, Squalus lebruni (Vaillant).


A behavioral study of the functions of the Rolandic cortex in the monkey.


Evaluation of the immediate effects of some fixatives upon the measurements of the brains of macaques.


Doctrine and experience: their influence upon the psychotherapist.


The problem of early termination: is it really the terminee.


Remainer patient attributes and their relation to subsequent improvement in psychotherapy.


A note on McNemar's on abbreviated Wechsler-Bellevue scales.


Conditioning of hostile verbalizations in a situation resembling a clinical interview.


Factor analysis of interview interaction behavior.


Problems of reliability in observing and coding social interactions.


Environmental factors and outpatient clinic intake.


A factor analysis of indices from four projective techniques associated with four different types of physical pathology.


Rorschach maturity scores of the mothers of schizophrenics.


A validity study of the autonomy and deference subscales of the EPPS.


Rorschach card rejection by psychiatric patients.


Relationship between achievement motivation scores and manifest anxiety scores.


Interrelationships among three measures of need achievement.


Differentiation of diagnostic groups by individual MMPI scales.


Changes in responses to a set of personality-inventory items as a function of age.


Ideal self instructions, MMPI profile changes, and the prediction of clinical improvement.


Extraversion, neuroticism, and verbal ability measures.


A comparison of Stanford-Binet and Colored Raven Progressive Matrices IQs for children with low socioeconomic status.


Trial making test as a screening device for the detection of brain damage.


Characteristics of volunteers and nonvolunteers in psychological experimentation.


Not alike responses in Wechsler's Similarities subtest.


Personal adjustment, assumed similarity to parents, and inferred parental-evaluations of the self.


A comparison of the Edwards PPS variables with some aspects of the TAT.


The PALS tests: a technique for children to evaluate both parents.


Cultural symbolism: the age variable.

Cultural symbolism: the age variable.


A study of the inorganic carbon dioxide in intact human enamel.


Modification of the organic matrix of sound dentin to collagenase-resistant forms.


Chemical and physical studies of enamel from human teeth. II. Specific gravity, nitrogen content, and hardness rating of discolored enamel.


Chemical and physical studies of enamel from human teeth. III. Specific gravity, nitrogen content, and histologic characteristics of opaque white enamel.


Further studies on the action of collagenase on sound and carious human dentin.


The measurement of the abrasion of human teeth by dentifrice abrasives: a test utilizing radioactive teeth.


Alteration of blood flow to the teeth. II. Its effect on dental caries and relation to salivary gland structure and function in the rat.


Experimental demonstration of tongue muscle origin in chick embryos.


Normal development of tooth buds cultured in vitro.


Continuous cementum apposition.

Continuous cementum apposition.


The melanoblast reservoir available to a feather papilla.


The mechanism of hardening of the salmonid egg membrane after fertilization or spontaneous activation.


Genetical studies on the skeleton of the mouse. XXIV. Further data on skeletal variation in wild populations.


Dental caries in the molar teeth of rats. I. Distribution of lesions induced by high-carbohydrate low-fat diets.


The development of the adrenals and sympathetic paraganglia in certain Madagascar insectivores.


Inherited retinal dystrophy in the mouse: its appearance in eyes and retinae cultured in vitro.


Cobalt-induced polycythemia. I. Clinical and hematologic observations.


A histochemical study of the attached gingiva in pregnancy.


The origin of the acoustic ganglion in the sheep.


Dental caries in the molar teeth of rats. II. A method for diagnosing and scoring several types of lesions simultaneously.


Congenital malformations in mouse embryos induced by 8-azaguanine.


Calcification and esterase localization in developing dentin.


The dependence of the embryonic inductive action of HeLa cells on their growth media.


An ultra-violet light method for producing haploid amphibian embryos.


Emergence of the permanent teeth in Pima Indian children: a critical analysis of method and an estimate of population parameters.


Oral Lactobacillus acidophilus growth inhibiting activity of human globulin.


Skeletal regeneration in amphibians.

Skeletal regeneration in amphibians.


Osteogenic potential of calcium hydroxide and other materials in soft tissue and bone wounds.


Factors affecting vertebral variation in mice. 4. Experimental proof of the uterine basis of a maternal effect.


Human urinary gonadotrophins. I. In relation to puberty.


Factors affecting the viability of frozen ovarian tissue.


The presence of an inherent reproductive cycle in the male laboratory rat.


The relationship of hyperglycaemia to hyperlipaemia and ketonaemia in depancreatized baboons (Papio ursinus).


Effect of deletion of bivalent trace minerals on growth and glycolytic activity of oral acidogenic microorganisms.


An investigation concerning the presence of free testosterone in the testis of the albino rat.


Capacitation of rabbit spermatozoa.

Capacitation of rabbit spermatozoa.


Adrenocortical activity in bovine pregnancy and parturition.


The effect of glucagon preparations on the uptake of glucose by isolated rat diaphragm.


The insulin activity of protein fractions of normal human serum.


The urinary excretion of oestrogens, pregnanediol and gonadotrophins during the menstrual cycle.


The effect of prolactin on urinary gonadotrophin assays.


The hydrolysis of conjugated oestrone, oestradiol-17 beta and oestriol in human urine.


Ovarian stimulation following cerebral lesions in ferrets.


Histological changes in the anterior pituitary gland of rats intoxicated with benzene.


Factors affecting the fertility and other characteristics of deep-frozen bull semen.


Seasonal rhythm in the morphology of the suprarenal cortex in women of child-bearing age.


An effect of antigen-antibody interaction on blood coagulation. Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the effect. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. This effect of antigen-antibody interaction may be involved in the production of tissue damage in vivo.


In vitro differentiation of virulent and attenuated polioviruses by their growth characteristics on MS cells. The MS character of polio-virus particles is described. Strains that produced relatively large plaques, up to 6 mm. in diameter, on a monkey stable (MS) cell line, were classified as MS(+). Such strains were found to include the highly virulent poliovirus strains. Attenuated strains appeared deficient in this gene, for they produced tiny plaques less than 1 mm. in size, or no visible plaques at all; they were considered as MS mutants. Strains of maximum neurovirulence for the monkey possessed the MS(+) and d(+) characters, while those of greatest attenuation were MS d. Strains possessing the MS d(+) character showed high or intermediate attenuation. Virulent strains grew equally well in MS or primary monkey kidney (MK) cells. Attenuated strains gave lower titers in MS cultures than in MK cultures. While MS cells after infection with a virulent virus yielded about 100 to 200 PFU per cell, only one PFU per MS cell was detected after infection with an attenuated virus. A study of newly isolated Type 3 strains showed them to consist of the MS(+)d(+) or MS d(+) type. The MS(+)d(+) virus proved to be highly paralytogenic for monkeys even by the intramuscular route, while the MS d(+) virus was of the partially attenuated type. The study of in vitro characters of viruses from children fed attenuated poliovirus offers a possibility for following genetic changes of the viruses after multiplication in the human enteric tract.


Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors. A study was made of the optimal conditions for the induction of mammary cancer in the rat. 3-Methylcholanthrene was administered via the gastrointestinal tract, and a simple technique was worked out for inducing mammary cancer regularly and rapidly. Under conducive conditions, which were readily reproduced, multiple mammary carcinomas and these tumors only were induced in every rat in repeated experiments in 60 days or less. In the strain of animal employed in the present experiments, the rapid induction of mammary cancer proved to be a function of (a) dosage, (b) the timing of administration of the aromatic hydrocarbon, and (c) a favoring hormonal status of the recipient. Most of the established tumors were hormone-dependent because they diminished markedly in size after hormone withdrawal through ovariectomy or hypophysectomy. Similar regression of the tumors was frequently achieved by the administration of dihydrotestosterone. Shrinkage of the cancers was accompanied by atrophic changes. Experimental mammary tumors with these physiologic characteristics have not been recognized hitherto. The minority of mammary cancers continued to grow after ovariectomy; these are hormone-independent tumors and tumors of this sort had a characteristic cytologic appearance following modification of the endocrine state. The cell population of a single tumor was not always uniform in its response to appropriate hormonal modifications. In certain tumors in response to changes in the endocrine status of the host many of the cells underwent atrophy whilst other adjacent cells in the same tumor continued to grow so that the net result was a hormone-independent tumor. Hypophysectomy was the most effective method found to induce regression of mammary cancer in the present experiments.


Identification of a toxic cellular component of group A streptococci as a complex of group-specific C polysaccharide and a protein. The toxic cellular component of Group A streptococci, which produces a chronic multinodular lesion of the dermal connective tissue of rabbits, has been isolated by means of differential centrifugation and electrophoresis. The substance appeared to be a macromolecular complex of polysaccharide and protein, the polysaccharide having the serological and chemical characteristics of the group-specific C substance. Evidence is presented indicating that the polysaccharide moiety is an essential part of the toxic complex. It is suggested that further studies of this material may help elucidate the mechanism of tissue damage in the non-suppurative sequelae of Group A streptococcal infections.


Comparative studies on the physical characteristics of the heritable haptoglobin groups of human serum. Ultracentrifugal studies of the alpha(2)-proteins of normal human serum before and after the addition of hemoglobin have revealed three separate and clearly distinguishable patterns based on the three major serum haptoglobin groups. Isolation of the three haptoglobin hemoglobin complexes disclosed characteristic patterns for each group. The heterozygote was found to possess electrophoretic and ultracentrifugal components not seen in either homozygote. Separation of normal human serum, to which hemoglobin had been added, by conventional starch zone electrophoresis resulted in three characteristic patterns which also permitted the ready identification of the serum haptoglobin group. The haptoglobin hemoglobin complex from Group 1-1 had the fastest mobility and that of Group 2-2 the slowest. The heterozygote Group 2-1 had an intermediate mobility. Immunologic differences between the haptoglobin hemoglobin complexes of the three groups could not be detected. Some of the variations in the reported electrophoretic and ultracentrifugal patterns of normal human serum could be reasonably ascribed to the group variation of the haptoglobins in man. The physical studies imply that the proteins characteristic of the heterozygote differ in size and charge from those present in either of the two homozygotes and indicate that the genetic control of the synthesis of the serum haptoglobins is probably exceedingly complex.


Intracellular localization of type 4 adenovirus. I. Cellular fractionation studies. HeLa cells infected with types 1 or 4 adenovirus were separated into cytoplasmic and nuclear fractions by mechanical disruption and differential centrifugation and the quantity of infectious virus in each was determined. The results showed that the majority of infectious virus of both types could be isolated in the cytoplasmic fraction. It was not possible to explain the large amount of type 4 virus in the cytoplasmic fraction by the number of nuclei disrupted in the fractionation procedure, but the amount of type 1 virus in the cytoplasmic fraction could have been contributed by disrupted nuclei. This suggested that there might be a basic difference in the intracellular formation of the two types of virus. The intracellular distribution of complement-fixing antigen was similar to that of infectious virus in type 4-infected cells. Technical difficulties, inherent in cellular fractionation studies, were encountered but did not appear to explain the results obtained.


Intracellular localization of type 4 adenovirus. II. Cytological and fluorescein-labelled antibody studies. HeLa cell cultures infected with adenovirus type 4 were studied by light and phase-contrast microscopy and by the fluorescent antibody technique for visualization of intracellular antigen. The findings were correlated with the growth curve of infectious virus, determined from companion cultures. The results indicated that those cells undergoing characteristic structural changes observable by light microscopy were those which contain viral antigen. The distribution of the majority of the antigen within the infected cells corresponded to that of the regularly aligned granules and crystal-like masses seen in the nuclei of cells in stained and in unfixed cultures. The production of infectious virus was closely correlated with the development of the characteristic nuclear changes.


The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus. The sera of certain patients with systemic lupus erythematosus contain an antibody-like substance capable of reacting with highly purified DNA preparations from widely divergent sources. Precipitin reactions have been demonstrated by double diffusion in agar and quantitative precipitin curves have been obtained. Complement was observed to be fixed in the reaction. Evidence was obtained that the serum factor possessed antigenic properties similar to those of gamma-globulins and migrated with this fraction on zone electrophoresis. The interaction of this factor with DNA exhibited certain specific characteristics which differ considerably from non-specific reactions between DNA and proteins in general. The DNA-precipitating factor appeared to be one of a number of related factors reacting with nuclear constituents of many different cells. It differed in certain respects from the "LE factor" which is responsible for the formation of "LE cells." The accumulated evidence, although not yet conclusive, favors the concept that the precipitating factor represents an antibody to DNA, and that it is one of a number of autoantibodies elicited in this disease.


Vexierversuch: the log relationship between word-frequency and recognition obtained in the absence of stimulus words.


The interstimulus interval and the latency of the conditioned eyelid response.


Aminonucleoside nephrosis. I. Electron microscopic study of the renal lesion in rats. Experimental renal disease was produced in young rats by daily subcutaneous injections of 6-dimethylamino purine, 3-amino-d-ribose (aminonucleoside). The physiologic, biochemical, and light microscopic changes were similar to those observed in human nephrosis. Electron microscopy of the glomeruli from animals which received seven or more daily injections of aminonucleoside revealed characteristic abnormalities of the epithelial cells of the glomerular capillaries. These changes consisted of swelling, coalescence, and eventual obliteration of the epithelial cell foot processes and an increase in the number and the size of epithelial cytoplasmic vacuoles. The serial development of the ultramicroscopic pathologic changes in the epithelial cells, as observed by study of animals through the course of the disease, indicated that the smudging of the foot processes occurred at the time of onset of severe proteinuria. Further changes, consisting of hypercellularity due primarily to an increase in the number of endothelial cells and an increase in the amount of basement membrane-like material, were regularly observed by the 12th day after injections were begun. These abnormalities were correlated with the development of uremia in the later stages of the disease process. The distal and proximal renal tubules were abnormal by the 7th day after injections were begun, and showed localized swelling between the cristae of the mitochondria and a decrease in over-all cytoplasmic density, described as hydropic change. Electron microscopy of glomeruli from animals which had partially recovered from aminonucleoside nephrosis revealed areas of normal epithelial cell morphology. This observation was interpreted as evidence of partial reversal of the ultramicroscopic changes in the recovery phase of the disease. These observations of the fine structure of pathologically altered glomeruli and tubules in aminonucleoside nephrosis are similar to our findings in human nephrosis as revealed by electron microscopy of serial renal biopsies.


Effects on verbal learning of anxiety, reassurance, and meaningfulness of material.


The relationship of stimulus similarity and number of responses.


Free recall of redundant strings of letters.


Training and transfer as a function of component interaction.


Acquisition of a verbal maze as a function of method of correction and number of alternate choices per unit.


Motivation shift in a complex learning task.


The acquisition of imitative and opposition responses under two conditions of instruction-induced set.


Alterations in critical flicker frequency as a function of age and light: dark ratio.


The role of the general physician in the changing picture of tuberculosis.


Reversal of intractable cardiac edema with prednisone (meticorten).


Beginnings of clinicopathologic correlation.


A new treatment for cutaneous larva migrans; employing oral promethazine.


Syringocystadenoma papilliferum; case with large rapidly growing lesion.


A pilot study in group weight control.

A pilot study in group weight control.


On the intestinal yeast flora of horses, sheep, goats and swine.


The morphology of Leptotrichia species.

The morphology of Leptotrichia species.


The purification and concentration of viruses and virus soluble antigens on calcium phosphate.


Some studies on the occurrence and properties of a large gram-negative coccus from the rumen.


The effect of infecting the cells of the de-embryonated egg with influenza virus on their uptake of glucose and amino acids.


Studies on the bacterial component of soybean root nodules: cytology and organization in the host tissue.


The globular involution forms of the bifid bacteria.


The effect of actidione and other antifungal agents on nucleic acid and protein synthesis in Saccharomyces carlsbergensis.


The differential effect of temperature on gas production by a coliform organism.


The sensitivity of Vibrio fetus to streptomycin and the emergence of resistant mutants.


Studies of extracellular and intracellular bacterial deoxyribonucleic acids.


A ready reckoner for the calculation of geometric mean antibody titres.


The influence of pH on the antibacterial action of subtilin A.


An electro-taxonomic survey of bacteria.


On the infrared absorption spectrum of Bacillus megaterium.


Torulopsis ingeniosa n. sp., from grass leaves.


Dihydrostreptomycin and anaerobiosis; indirect evidence for two sites of action of dihydrostreptomycin.


Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium.


The transition between different physiological states during balanced growth of Salmonella typhimurium.


The nutritional requirements of rumen strains of Streptococcus bovis considered in relation to dextran synthesis from sucrose.


The effect of residual water on the survival of dried bacteria during storage.


Lysogeny and conversion in mitis and mitis-like Corynebacterium diphtheriae.


Problems of method and theory in controlling rest activity.


A study of clustering in free recall based on synonyms.


The psychopathic personality: a content analysis of the concept.


The nonsexual significance of some simple geometric symbols.


Differences between well and poorly adjusted young adults based upon psychologists' ratings and subjects' self-ratings.


Set theory models for research concerning creative thinking and imagination.


The communication clinic approach: a proposed solution to the business communication problem.


Set theory models for research concerning criticism and appreciation.


Some historical notes and a brief summary of the experimental method and findings of Ferdinando Cazzamalli.


Stimulus generalization and anxiety.

Stimulus generalization and anxiety.


Auditory irritants and impalpable pain.

Auditory irritants and impalpable pain.


Perceptual learning: differentiation and enrichment of past experience.


[Facial hemiatrophy with alopecia (Romberg's syndrome) associated with heterochromic cyclitis (Fuchs' syndrome)].


The longevity and mortality of thoroughbred mares.


Senescence and the metabolism of various tissues of rats.


Age changes in the calcium content of rat brain.


The functional significance of mucopolysaccharide obtained from cattle aorta.


Effects of castration and/or hormonal therapy upon the hematocrit in aged male rats.


Mucopolysaccharides of human arterial tissue. IV. Analysis of electrophoretically separated fractions.


Swimming speed of the albino rat: I. Age and sex differences.


Swimming speed of the albino rat. II. Fatigue, practice, and drug effects on age and sex differences.


Some effects of age on short term learning and remembering.


Sex hormone replacement in the aged. I. Psychological and medical evaluation of administration of androgen-estrogen and of androgen-estrogen combined with reserpine.


The effects of age on critical thinking ability.


Task alternation time in relation to problem difficulty and age.


Movement time, reaction time, and age.

Movement time, reaction time, and age.


Rigidity factors in the testing of middle-aged subjects.


Rinderpest immunity in calves. I. The acquisition and persistence of maternally derived antibody.


Rinderpest immunity in calves. II. Active immunization.


The type classification of Staphylococcus aureus: a comparison of phage-typing with serological typing.


An insecticide-bait-box method for the control of sylvatic plague vectors.


The antibody response in man following infection with viruses of the pox group. III. Antibody response in smallpox.


The antibody response in man following infection with viruses of the pox group. II. Antibody response following vaccination.


DISINFECTION of fabrics with gaseous formaldehyde.


Numerical studies on some contagious distributions.