PHOTOSENSITIVITY OF THE FROG IRIS.

PHOTOSENSITIVITY OF THE FROG IRIS. The absorption of quanta by rhodopsin leads to the contraction of frog iris muscle. The contractions reach a maximum after about 8 sec. in the light. When the light is turned off the irises relax exponentially with a half-time of about 6 sec. Membrane polarization is not necessary for the response but calcium movement and membrane permeability changes probably are. The response is not mediated by acetylcholine or epinephrine. The curves of log It vs. log t for constant response amplitude bend progressively upward away from a unit slope line at short times as larger response criteria are used because (a) light influences tension development over longer times and (b) the higher intensity, shorter duration flashes are less effective.


QUANTUM RELATIONS OF THE RAT ELECTRORETINOGRAM. The rat retina is uniform and contains almost exclusively rods. Therefore the rat eye, when uniformly illuminated, produces a gross electroretinogram (ERG) which is simply related to the activity of the individual retinal sources of the ERG. Characteristics of ERG's are shown on an intensity scale of the average number of quanta absorbed per rod per stimulus flash obtained by direct accurate measurement of all quantities involved. An independent check on the accuracy of these measurements is applied to pigment-bleaching data reported by Dowling (1963). When ERG characteristics are placed on this scale it is found that: (a) The b-wave can usually be observed when fewer than one out of two hundred rods absorbs a quantum, the threshold being determined by the noise of the preparation. (b) Near threshold the b-wave amplitude is proportional to intensity. (c) The a-wave appears when there are more than two to four absorptions per rod per flash. (d) The b-wave latency decreases with intensity, and the amplitude becomes proportional to the logarithm of intensity when fewer than one out of ten rods absorbs a quantum. This implies that the b-wave sources must combine excitation from more than one rod (probably more than seven). Therefore the b-wave cannot arise from independent rods or rod-bipolar synapses, but probably reflects activity of entire inner nuclear layer cells.


NEURAL AND PHOTOCHEMICAL MECHANISMS OF VISUAL ADAPTATION IN THE RAT. The effects of light adaptation on the increment threshold, rhodopsin content, and dark adaptation have been studied in the rat eye over a wide range of intensities. The electroretinogram threshold was used as a measure of eye sensitivity. With adapting intensities greater than 1.5 log units above the absolute ERG threshold, the increment threshold rises linearly with increasing adapting intensity. With 5 minutes of light adaptation, the rhodopsin content of the eye is not measurably reduced until the adapting intensity is greater than 5 log units above the ERG threshold. Dark adaptation is rapid (i.e., completed in 5 to 10 minutes) until the eye is adapted to lights strong enough to bleach a measurable fraction of the rhodopsin. After brighter light adaptations, dark adaptation consists of two parts, an initial rapid phase followed by a slow component. The extent of slow adaptation depends on the fraction of rhodopsin bleached. If all the rhodopsin in the eye is bleached, the slow fall of threshold extends over 5 log units and takes 2 to 3 hours to complete. The fall of ERG threshold during the slow phase of adaptation occurs in parallel with the regeneration of rhodopsin. The slow component of dark adaptation is related to the bleaching and resynthesis of rhodopsin; the fast component of adaptation is considered to be neural adaptation.


TRICHOPHYTON YAOUNDEI. A DERMATOPHYTE INDIGENOUS TO AFRICA.


ELECTROLYTE METABOLISM IN HELA CELLS.

ELECTROLYTE METABOLISM IN HELA CELLS. Methods have been developed to study cellular Na, K, and Cl concentrations in HeLa cells. Cell [Na] and [K] are functions of the age of the culture. As the culture grows [K], expressed in mmols/liter cell H(2)O, rises from an initial value of 121 to a peak of 206 at about 4 days, and thereafter falls until it has almost returned to the initial value by the 9th day. [Na] falls as [K] rises, but there is no fixed relationship between the cellular concentrations of the two cations. There is, however, a correlation between generation time and cellular [K]. Measurements of net K uptake and net Na extrusion were carried out during 1 hour incubation at 37 degrees C of low K cells. Both net K uptake and net Na extrusion took place against chemical concentration gradients, so that at least one transport system must be active; if the Cl distribution is passive both net K uptake and net Na extrusion are active. Studies with inhibitors of respiration and glycolysis lead to the conclusion that respiration is not required for these net transports, which appear to derive their energy from glycolytic sources.


LIGHT-SENSITIVE PSORIASIS AND ANTIMALARIAL DRUGS.


THE ROLE OF PSEUDOMONAS AERUGINOSA IN NAIL DISEASE.


RESPONSE OF HUMAN SWEAT GLANDS TO LOCAL HEATING.


MITOTIC ACTIVITY OF WOUNDED HUMAN EPIDERMIS.


THE BACTERIA RESPONSIBLE FOR AXILLARY ODOR. II.


THE VALUE OF MACKENZIE'S "HAIR BRUSH" TECHNIC IN THE ISOLATION OF T. MENTAGROPHYTES FROM CLINICALLY NORMAL GUINEA-PIGS.


QUANTITATIVE RESPONSE OF THE MELANOCYTES TO ULTRAVIOLET LIGHT.


PRELIMINARY OBSERVATIONS ON SENILE ELASTOSIS USING THE ELECTRON MICROSCOPE.


PERFUSION SYSTEM FOR  REPLICATE MAMMALIAN CELL CULTURED IN T-60 FLASKS.


DECLINE IN MORTALITY FROM GASTRIC CANCER IN NATIVE-BORN AND  FOREIGN-BORN RESIDENTS OF NEW YORK CITY.


DIFFERENCES IN RESPONSE OF HAMSTER TUMOR CELLS INDUCED BY POLYOMA  VIRUS TO INTERFERING VIRUS AND INTERFERON.


PHOTODYNAMIC BIOASSAY OF  BENZO(A)PYRENE WITH PARAMECIUM CAUDATUM.


GENETIC STUDY OF MODIFIED SUSCEPTIBILITY TO TUMOR TRANSPLANTS IN RECIPROCAL  RESISTANT BACKCROSS MICE.


THE URINARY EXCRETION OF ADRENAL CORTICOID METABOLITES IN MYOTONIC DYSTROPHY.


THE NATURE OF THE "PARTIAL" TOLERANCE INDUCED BY PARITY.


GROSS DISTRIBUTION OF ATHEROMA IN CLINICAL PERIPHERAL VASCULAR DISEASE.


INCREASE OF INDUCED SKIN TUMORS IN THE MOUSE BY THE LETHAL  YELLOW GENE (AY).


FORMATION OF PURE SUSPENSIONS OF MAST CELLS IN TISSUE CULTURE BY  DIFFERENTIATION OF LYMPHOID CELLS FROM THE MOUSE THYMUS.


A STUDY OF SUBARACHNOID HEMORRHAGE AND INTRACRANIAL ANEURYSM.


THE URINARY EXCRETION OF THE NEUTRAL 17-KETOSTEROIDS IN MYOTONIC DYSTROPHY.


CARCINOGENICITY  OF EPOXIDES, LACTONES, AND PEROXY COMPOUNDS.


NEW METHOD FOR DETECTION OF MOUSE MAMMARY TUMOR VIRUS. I. INFLUENCE OF FOSTER  NURSING ON INCIDENCE OF HYPERPLASTIC MAMMARY NODULES IN BALB/CCRGL MICE.


UNUSUAL SITES FOR "SEGMENTAL" CEREBROVASCULAR OCCLUSION.


FACTORS DETERMINING CHRONICITY OF LIVER DISEASE. A PROGRESS REPORT.


NEW METHOD FOR DETECTION OF MOUSE MAMMARY TUMOR VIRUS. II. EFFECT OF  ADMINISTRATION OF LACTATING MAMMARY TISSUE EXTRACTS ON INCIDENCE OF HYPERPLASTIC MAMMARY  NODULES IN BALB/CCRGL MICE.


ELECTROPHORETIC VARIATION AND SEX DIMORPHISM OF THE  MAJOR URINARY PROTEIN COMPLEX IN INBRED MICE: A NEW GENETIC MARKER.


CLINICO-PATHOLOGICAL CONFERENCE=  JAUNDICE, ASCITES AND CORNEAL DISCOLORATION WITH NORMAL CERULOPLASMIN.


RADIOLOGICAL NOTES.

RADIOLOGICAL NOTES.


SEIZURES INDUCED BY MOVEMENT: REPORT OF A CASE RELIEVED BY OPERATION.


THE RELATIONSHIP BETWEEN GENERALIZED PAROXYSMAL E.E.G. DISCHARGES AND VARIOUS TEST SITUATIONS IN TWO EPILEPTIC PATIENTS.


MYOPATHIC CHANGES IN A MUSCULAR DYSTROPHY CARRIER.


THE LOCALIZATION OF ALKALINE PHOSPHATASE ACTIVITY IN CEREBRAL BLOOD VESSELS.


THE EFFECT OF METABOLIC ACIDOSIS AND ALKALOSIS ON THE BLOOD FLOW THROUGH THE CEREBRAL CORTEX.


TRIGEMINAL ROOT AND GANGLION INJECTIONS USING PHENOL IN GLYCERINE FOR THE RELIEF OF TRIGEMINAL NEURALGIA.


FUNDAMENTALS OF HUMAN MOTION.

FUNDAMENTALS OF HUMAN MOTION.


RESULTS OF ANTERO-LATERAL CORDOTOMY FOR PAIN IN CANCER.


A FATAL CASE OF CEREBRAL ABSCESS DUE TO NOCARDIA ASTEROIDES.


KCOS: THE RURAL EXTENSION CLINICS.

KCOS: THE RURAL EXTENSION CLINICS.


THE PSYCHIC COMPONENT.

THE PSYCHIC COMPONENT.


GUILLIAN-BARRE SYNDROME (ACUTE INFECTIOUS POLYNEURITIS).


GROUP INSURANCE FOR THE PROFESSION'S HEALTH.


THIS IS THE NEW CHICAGO OSTEOPATHIC HOSPITAL.


ORAL TUMORS OF INFANCY AND CHILDHOOD. A SURVEY OF 293 CASES.


BENIGN MESONEPHRIC PAPILLARY AND POLYPOID TUMORS OF THE CERVIX IN CHILDHOOD.


DIARRHEA IN A CHILD WITH A CATECHOLAMINE-SECRETING GANGLIONEUROMA. CASE REPORT AND REVIEW OF THE LITERATUTE.


L-PHENYLALANINE MUSTARD AS A TREATMENT FOR METASTATIC OSTEOGENIC SARCOMA IN CHILDREN.


DIASTEMATOMYELIA.

DIASTEMATOMYELIA.


MULTILOCULAR CYSTS OF THE KIDNEY IN CHILDREN. REPORT OF A CASE AND REVIEW OF THE LITERATURE.


ALLERGENIC PROPERTIES OF MILK AND MILK PROTEINS. A STUDY OF ANAPHYLAXIS IN GUINEA PIGS.


PERICARDITIS WITH EFFUSION IN  INFANTS AND CHILDREN.


SELENIUM CONTENT OF HUMAN MILK: POSSIBLE EFFECT ON DENTAL CARIES.


VARIATION OF THE ORAL GALACTOSE TOLERANCE TEST WITH AGE.


SUDDEN AND UNEXPECTED DEATH IN INFANTS. I. GAMMA GLOBULIN LEVELS IN THE SERUM.


THE CHROMOSOME COUNT IN A TRUE HERMAPHRODITE.


OBSERVATIONS ON THE NEWBORN DYSMATURE INFANT AND HIS DEVELOPMENT DURING THE FIRST 9 MONTHS.


LEUCINE-INDUCED HYPOGLYCEMIA. III. THE BLOOD GLUCOSE DEPRESSANT ACTION OF LEUCINE IN NORMAL INDIVIDUALS.


A RE-EVALUATION OF THE DANGERS OF CLOROX INGESTION.


CLINICAL PATHOLOGICAL CONFERENCE. THE CHILDREN'S HOSPITAL MEDICAL CENTER, BOSTON, MASS.


FOLIC ACID DEFICIENCY IN CHILDREN WITH CELIAC DISEASE.


CURRENT STATUS OF EXCHANGE TRANSFUSION.

CURRENT STATUS OF EXCHANGE TRANSFUSION.


THE USE OF EXTERNALLY MONITORED RADIOISOTOPE TECHNIQUES IN THE STUDY OF REGIONAL CAROTID BLOOD FLOW UNDER VARIOUS EXPERIMENTAL CONDITIONS.


A COMPARISON OF SEVERAL OSMOTIC DIURETICS IN HYDROPENIC AND HYDROPENIC-DOCA-PITRESSIN TREATED DOGS.


VARIATIONS IN THE AMOUNT OF SALINE EXTRACTABLE COLLAGEN IN SKIN DISTANT TO A HEALING WOUND.


VISCOMETRIC HARDENING OF GELATIN SOLS IN THE PRESENCE OF CERTAIN INTERMEDIARY METABOLITES.


HEMODYNAMICS STUDIES OF DOGS UNDER PENTOBARBITAL AND MORPHINE CHLORALOSE ANESTHESIA.


EFFECT OF CATECHOL AMINES DURING TRAUMATIC SHOCK IN THE RAT.


ACUTE MYOCARDIAL INFARCTION IN A LARGE INDUSTRIAL POPULATION: REPORT OF A 6-YEAR STUDY OF 1,356 CASES.


POSTURAL OPHTHALMODYNAMOMETRY IN CAROTID ARTERY OCCLUSIVE DISEASE.


METHYLDOPA AND HYDROCHLOROTHIAZIDE IN PRIMARY HYPERTENSION: CONTROLLED CLINICAL TRIAL OF DRUGS SINGLY AND IN COMBINATION.


THE VAGINAL CYTOGRAM: A GUIDE TO SUBSTITUTION THERAPY FOR STATES OF OVARIAN DEFICIENCY.


STATISTICS IN THE PRACTICE OF MEDICINE.

STATISTICS IN THE PRACTICE OF MEDICINE.


BACTERIAL SHOCK: A SERIOUS COMPLICATION IN UROLOGICAL PRACTICE.


HALLUCINOGENIC AGENTS.

HALLUCINOGENIC AGENTS.


TREATMENT OF THE MORE COMMON WORM INFECTIONS.


CAIUS OF GONVILLE AND CAIUS COLLEGE.

CAIUS OF GONVILLE AND CAIUS COLLEGE.


SELF-INDUCED STRAMONIUM INTOXICATION.

SELF-INDUCED STRAMONIUM INTOXICATION.


PROLONGED TOLBUTAMIDE-INDUCED HYPOGLYCEMIA.


OPEN FRACTURE DISLOCATION OF THE KNEE.

OPEN FRACTURE DISLOCATION OF THE KNEE.


HOMOGRAFT REJECTION. THE NATURE OF IMMUNE RESPONSE AND MEANS OF INDUCING TOLERANCE.


ELEVATED INTRAOCULAR PRESSURE FOLLOWING CORTICOSTEROID EYE DROPS.


[STUDIES ON EXPERIMENTAL CARDIAC NECROSIS PRODUCED BY  MEANS OF INTRAVENOUS ADMINISTRATION OF PROTEOLYTIC ENZYME. THE CHANGES OF THE ACTIV-  ITIES OF SOME SERUM ENZYMES AND THE HISTOLOGICAL FINDINGS OF SEVERAL ORGANS IN PAPAININJECTED RABBITS].


A STUDY ON THE NATURE OF PLATEAU IN THE MEMBRANE ACTION POTENTIAL OF CARDIAC MUSCLE FIBER OF THE RABBIT.


CLINICAL EXPERIENCE WITH "ACTINOMYCIN D" ON WILMS' TUMOR.


STUDIES ON THE PARASITES OF THE JAPANESE HOUSE MOUSE, MUS MOLOSSINUS. II. INTESTINAL PROTOZOA IN THE MOUSE LIVING IN TWO DIFFERENT ENVIRONMENTS AND SEASONS.


THE EXPERIMENTAL STUDY ON SERUM BETA-GLUCURONIDASE ACTIVITY AND TRANSAMINASE ACTIVITY IN RATS SUBJECTED TO PARTIAL HEPATECTOMY.


SAFETY JIG FOR INSERTION OF STOPPERS INTO WATER BOTTLES.


EFFECT OF MER29 (TRIPARANOL) ON HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS IN RABBITS.


FEEDING TROUGH FOR GUINEA PIG.

FEEDING TROUGH FOR GUINEA PIG.


MODIFICATION OF ANAL CUP TECHNIQUE FOR SMALL EXPERIMENTAL ANIMALS.


THE ESTABLISHMENT OF A MARMOSET BREEDING COLONY AND ITS FOUR PREGNANCIES.


SOME AIDS IN THE HANDLING OF LARGE NUMBERS OF MICE.


A SMALL ANIMAL EUTHANASIA CHAMBER.

A SMALL ANIMAL EUTHANASIA CHAMBER.


THE DIAGNOSIS OF SOME FORMS OF ECTOPARASITISM OF MICE.


THE DIAGNOSIS AND CONTROL OF ECTROMELIA INFECTION OF MICE.


CHRONIC RESPIRATORY DISEASE IN MICE AND RATS.


SALMONELLOSIS IN MICE-DIAGNOSTIC PROCEDURES.


POLYOMA AND OTHER INDIGENOUS MOUSE VIRUSES.


MANAGEMENT OF A SPECIFIC PATHOGEN-FREE GUINEA PIG COLONY.


THE DIAGNOSIS OF PSEUDOMONAS AERUGINOSA INFECTION OF MICE.


CRICOARYTENOID ARTHRITIS.

CRICOARYTENOID ARTHRITIS.


PATHOLOGY AND SURGERY OF BELL'S PALSY.

PATHOLOGY AND SURGERY OF BELL'S PALSY.


THE LOW-FREQUENCY AIR-BONE GAP.

THE LOW-FREQUENCY AIR-BONE GAP.


LATEROTORSION: A VESTIBULAR-SPINAL REFLEX.


EXPERIMENTAL OBSERVATIONS ON PROSTHESES AND OVAL WINDOW COVERINGS IN CATS AS RELATED TO STAPEDIAL SURGERY.


THE USE OF HOMOLOGOUS VEIN GRAFTS IN OTOLARYNGOLOGY.


CERVICAL LYMPHANGIOGRAPHY.

CERVICAL LYMPHANGIOGRAPHY.


OTOSCLEROSIS: ETIOLOGY, DIAGNOSIS AND TREATMENT.


MALIGNANT TUMORS METASTATIC TO THE PARANASAL SINUSES: CASE REPORT AND REVIEW OF THE LITERATURE.


DIVERTICULITIS: A MEDICAL OR SURGICAL PROBLEM?


STUDIES OF PHYSIOLOGICAL AND CLINICAL ASPECTS OF ACUTE RESPIRATORY ACIDOSIS.


MULTIFOCAL PREMATURE VENTRICULAR SYSTOLES AND VENTRICULAR TACHYCARDIA: SUCCESSFUL TREATMENT BY ELECTRIC COUNTERSHOCK.


16 MM COLORED MOTION PICTURE OF THE INTERIOR OF THE HUMAN BLADDER.


ELECTRON MICROSCOPIC OBSERVATIONS OF THE CYST OF ULTIMOBRANCHIAL ORIGIN FOUND IN THE THYROID GLAND OF A DOG.


INFLUENCE OF THE BROWN-PEARCE CARCINOMA GROWTH ON THE CONNECTIVE TISSUE PROLIFERATION.


DIFFERENCES BETWEEN EXCITATION PATTERNS OF FAST AND SLOW MOTOR SYSTEMS IN THE TOAD.


ANALYSIS OF ANTIDROMIC TEGMENTAL RESPONSES CAUSED BY STIMULATION TO THE SPINAL VENTRAL HORN OF THE TOAD.


DETERMINATION OF RIBOFLAVIN-5'-MONOSULFATE.


EFFECTS OF NURSING METHODS ON THE DEVELOPMENT OF INFANT HIP-BONES.


CHEMICAL ALTERATION OF URINE.

CHEMICAL ALTERATION OF URINE.


HIGH-SENSITIVITY DETECTION OF AMINO-ACIDS BY GAS CHROMATOGRAPHY AND ELECTRON AFFINITY SPECTROMETRY.


PLUTONIUM-239 AND OTHER NUCLIDES IN GROUND-LEVEL AIR AND HUMAN LUNGS DURING SPRING 1962.


RETINAL PHOTOCOAGULATION BY LASERS.

RETINAL PHOTOCOAGULATION BY LASERS.


PARTITION OF DIVALENT CATIONS BETWEEN BACTERIAL WALL AND CELL CONTENTS.


PATHWAY OF REDUCTION OF METMYOGLOBIN AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE BY ILLUMINATED CHLOROPLASTS.


QUANTITATIVE RELATIONSHIPS IN TUMOURS INDUCED BY A VIRUS AND BY OTHER AGENTS.


CYTOCHEMICAL MEASUREMENT OF PROTEIN SULPHYDRYLS IN CELL LINES OFDIFFERENT RADIOSENSITIVITY.


MUSCLE BIOPSY IN MAN: AN INDEX OF CELLULAR POTASSIUM?


ISOLATION AND CHARACTERIZATION OF MURAMIC ACID FROM TWO SPIROCHAETES: BORRELIA DUTTONI AND LEPTOSPIRA BIFLEXA.


APPARENT RELATIVE MOVEMENT OF 'UNSHARP' AND 'SHARP' VISUAL PATTERNS.


CONTINUED X-RAY MICROANALYSIS OF RADIOACTIVE FALL-OUT PARTICLES DURING THE YEAR 1962.


SULPHITOCOBALAMIN.

SULPHITOCOBALAMIN.


TOTAL SYNTHESIS OF ADRENOCORTICOTROPHIC HORMONE.


ISOLATION OF A SIALIC ACID-RICH GLYCOPROTEIN FRACTION FROM NORMAL HUMAN URINE.


QUANTITATIVE RELATIONS BETWEEN FERRITIN AND SIDERIN.


FURTHER SEPARATION OF IODINE, MONOIODOTYROSINE AND DIIODOTYROSINE BY MEANS OF MODIFIED CHARCOAL.


FREE AMINO-ACID CONTENT OF TOBACCO SEEDS.


INTERMEDIARY METABOLISM IN BULL SEMEN.

INTERMEDIARY METABOLISM IN BULL SEMEN.


A RAPID METHOD OF DISK ELECTROPHORESIS.

A RAPID METHOD OF DISK ELECTROPHORESIS.


ELECTRON MICROSCOPE EXAMINATION OF MYOGLOBIN.


INFLUENCE OF DIET ON URINE CONCENTRATION IN APLODONTIA RUFA AND THE RABBIT.


EFFECTS OF D,1-ALDOSTERONE ON RENAL EXCRETION OF WATER, SODIUM, AND POTASSIUM INDUCED BY RENIN.


PERFUSION OF THE VIABLE SHEEP FOETUS.

PERFUSION OF THE VIABLE SHEEP FOETUS.


APPLICATION OF THE ARRHENIUS EQUATION TO RAT TAIL TENDON COLLAGEN.


DIFFERENCES BETWEEN CORTICAL RECRUITING RESPONSES OBSERVED DURING WAKEFULNESS AND NATURAL SLEEP.


ANTIHAEMOPHILIC GLOBULIN IN FROZEN PLASMA.


OXIDATION OF REDUCED GLUTATHIONE BY ACETYLPHENYLHYDRAZINE, HEMOGLOBIN AND ERYTHROCYTES.


INFILTRATION OF INTRA-ABDOMINAL ORGANS BY ASCITES TUMORS.


INDUCTION OF TUMOURS OF THE STOMACH IN RATS AND MICE BY N-NITROSO-NALKYLURETHANES.


EFFECT OF 8-AZAGUANINE ON THE SPECIFICITY OF ANTIGENS SYNTHESIZED BY E. COLI B/R2.


EFFECT OF ULTRA-VIOLET LIGHT ON SKIN COLLAGEN.


FREEZE-DRYING AND RADIATION PROTECTION.

FREEZE-DRYING AND RADIATION PROTECTION.


INFLUENCE OF TEMPERATURE AND MEDIUM ON THE X-RAY SENSITIVITIES OF LEUKEMIA CELLS IN VITRO.


NEMASPERM AND PITUITARY INHIBITION.

NEMASPERM AND PITUITARY INHIBITION.


LINEAR RELATIONSHIP BETWEEN TEMPERATURE AND UPTAKE OF OXYGEN IN EUGLENA GRACILIS.


A PHOTOGRAPHIC METHOD FOR THE DETECTION OF RARE BACTERIAL MUTANTS IN THE REPLICA PLATING TECHNIC.


SYNTHESIS OF VIRAL RIBONUCLEIC ACID BY A CHEMICALLY INACTIVATED INFLUENZA VIRUS.


CONCENTRATING EJACULATED SPERM FOR ELECTRON MICROSCOPY.


3,4-DIMETHOXYPHENYLETHYLAMINE AND OTHER AMINES IN THE URINE OF SCHIZOPHRENIC PATIENTS.


MYOCARDIAL ISCHEMIA AFTER LIGATION OF AN ANOMALOUS  LEFT CORONARY ARTERY ARISING FROM THE PULMONARY ARTERY.


THE PROBLEM OF THE ANOMALOUS LEFT CORONARY ARTERY ARISING FROM THE PULMONARY ARTERY IN OLDER CHILDREN. REPORT OF THREE CASES.


PERSISTENT GASTROESOPHAGEAL REFLUX INDUCED DURING PROLONGED GASTRIC INTUBATION.


EFFECT OF AN OVULATORY SUPPRESSANT ON THE SERUM PROTEIN-BOUND IODINE AND THE RED-CELL UPTAKE OF RADIOACTIVE TRI-IODOTHYRONINE.


MEDICAL CARE: ITS SOCIAL AND ORGANIZATIONAL ASPECTS. THE HOSPITAL AND SOCIAL MEDICINE.


PHYSIOLOGIC ASPECTS OF PROLONGED WEIGHTLESSNESS. BODY-FLUID DISTRIBUTION AND THE CARDIOVASCULAR SYSTEM.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL. CASE 57-1963.


EPIDEMIC TUBERCULOSIS: FAILURE TO DETECT SOURCE OWING TO FAMILY DISORGANIZATION.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL. CASE 56-1963.


THE KREBIOZEN AFFAIR.

THE KREBIOZEN AFFAIR.


RENAL DISEASE IN SYSTEMIC  LUPUS ERYTHEMATOSUS.


CARCINOMA OF THE LUNG WITH INAPPROPRIATE ANTIDIURESIS. DEMONSTRATION OF ANTIDIURETIC-HORMONE-LIKE ACTIVITY IN TUMOR EXTRACT.


EFFECT OF A LOW-REFINED-  CARBOHYDRATE DIET ON THE NONFASTING HEMOGLOBIN LEVEL.


AN EVALUATION OF CLINICAL AND LABORATORY FINDINGS IN MALE SUBJECTS ON LONG-TERM, LOW-FAT, LOW-PROTEIN DIETS.


MEDICAL CARE: ITS SOCIAL AND ORGANIZATIONAL ASPECTS. MEDICAL EDUCATION IN THE COMMUNITY HOSPITAL.


WILLIAM READ AND HIS BOOKS. A BIBLIOGRAPHIC RESEARCH PATTERN IN 1861.


GLYCOPROTEINS: STRUCTURE, METABOLISM AND BIOLOGY.


CURRENT CONCEPTS IN THERAPY ACTIVE IMMUNIZATIONS.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL. CASE 58-1963.


URINARY EXCRETION ASSAYS OF PITUITARY LUTEINIZING HORMONE (LH) RELATED TO ENDOMETRIAL CARCINOMA.


THE CLASSIFICATION OF FETAL HEART RATE. I. A WORKING CLASSIFICATION.


THE PLACENTA IN TRISOMY 18 SYNDROME. REPORT OF 2 CASES.


CHORIONIC VILLI IN NORMAL PREGNANCY, PRE-ECLAMPTIC TOXEMIA, ERYTHROBLASTOSIS, AND DIABETES MELLITUS. A LIGHT- AND ELECTRON-MICROSCOPE STUDY.


CIRCULATING FIBRINOLYTIC ACTIVITY--A PRECURSOR OF HYPOFIBRINOGENEMIA FOLLOWING FETAL DEATH IN UTERO.


SOME FETAL EFFECTS OF MATERNAL CIGARET SMOKING.


PRESSOR AND EMETIC EFFECTS OF OXYTOCICS IN THE FOURTH STAGE OF LABOR.


PREVENTION OF COMPLICATIONS IN CERVICAL CONIZATION.


UNCOMMON MYOGENIC TUMORS OF THE FEMALE GENERATIVE TRACT.


MASCULINIZATION OF FEMALE INFANTS ASSOCIATED WITH NORETHINDRONE ACETATE.


GRANULOSA-CELL-TUMOR DIAGNOSIS BY URINARY-ESTROGEN ASSAY. REPORT OF A CASE.


ISOSEXUAL PRECOCITY PRODUCED BY AN OVARIAN THECOMA. REPORT OF A CASE.


LEIOMYOSARCOMA OF THE CERVIX.

LEIOMYOSARCOMA OF THE CERVIX.


HAZARDS OF ELECTIVE INDUCTION OF LABOR.

HAZARDS OF ELECTIVE INDUCTION OF LABOR.


GIANT FIBROMYOMA OF THE VAGINA COMPLICATING PREGNANCY. REPORT OF A CASE.


TRANSVERSE VAGINAL SEPTUM--A RARE CAUSE OF DYSTOCIA OF LABOR. REPORT OF A CASE.


THE MANAGEMENT OF LABOR WITH A BREECH PRESENTATION.


PRIMARY ENDOMETRIOSIS OF THE CERVICAL REMNANT FOLLOWING A MANCHESTER REPAIR OPERATION.


MALIGNANT BRENNER TUMOR ASSOCIATED WITH ENDOMETRIAL ADENOCARCINOMA.


OMISSION OF BLADDER CATHETERIZATION WITH GYNECOLOGIC OPERATIONS.


A MODIFIED WEIGHTED VAGINAL SPECULUM.

A MODIFIED WEIGHTED VAGINAL SPECULUM.


EMERGENCY TREATMENT OF BITES AND STINGS.


VENOUS-STASIS RETINOPATHY OF OCCLUSIVE DISEASE OF THE CAROTID ARTERY.


A SINGLE-INJECTION TECHNIC FOR RENAL PHOTOSCANNING WITH ORTHO-IODOHIPPURATE-I-131. A PRELIMINARY REPORT.


DIVERTICULITIS OF THE COLON.

DIVERTICULITIS OF THE COLON.


ALCOHOLISM AND ITS IMPLICATIONS.

ALCOHOLISM AND ITS IMPLICATIONS.


SURGICAL INDICATIONS AND RESULTS OF SPLENECTOMY.


ISAAC RAY 1807-1881.

ISAAC RAY 1807-1881.


MORBIDITY REPORTING.

MORBIDITY REPORTING.


SOME FALLACIES IN THE STUDY OF HOMINID PHYLOGENY.


ENOVID: CONTRACEPTIVE PILL AND RECENT FDA REPORT CLEARING IT STIR  CONTINUED MEDICAL DISPUTE.


IMPURITY IN HALOTHANE ANESTHETIC.

IMPURITY IN HALOTHANE ANESTHETIC. A halogenated butene has been isolated from commercially available halothane (Fluothane). Its concentration increases under the conditions in which halothane is commonly used in clinical work.


ACETYLCHOLINE-LIKE ACTIVITY IN SCIATIC NERVE. Extracts of sciatic nerve exhibit acetylcholine-like activity that is only partly attributable to acetylcholine. The extracts show relatively greater activity on the rectus abdominis muscle of the frog than on the ileum of the guinea pig. To prevent the action of the extract on the frog rectus abdominis muscle, a greater concentration of d-tubocurarine is required than is necessary to prevent the action of known acetylcholine.


LOW DOSE RADIATION OF THE DEVELOPING BRAIN. X-irradiation administered in single doses of 10 to 40 r has a widespread effect on the developing rat brain. It first diminishes the formation of cytoplasmic basophilic material in the nerve cells and inhibits their growth. Single doses of 20 to 40 r cause permanent alterations of individual nerve cells, and interfere with their organization into neuronal assemblies, such as layers of the cerebral cortex.


DDT AND DIELDRIN IN RIVERS: A REPORT OF THE NATIONAL  WATER QUALITY NETWORK. As a part of the waterquality surveillance activities of the National Water Quality Network at 101 sampling stations, insecticides were identified in 38 samples from ten rivers during the period May through December 1962. Both DDT and dieldrin were identified by infrared and gas chromatographic analysis of carbon adsorption extracts.


FLAVIN SENSITIZED PHOTOREACTIONS: EFFECTS OF 3-(P-CHLOROPHENYL)-  1,1-DIMETHYLUREA. Photooxidation reactions, which were inhibited by high concentrations of oxygen, were affected by the addition of 3-(p-chlorophenyl)-1,1-dimethylurea (CMU), but the response varied with the substrate being oxidized. With ascorbic acid and 2,3-diketogulonic acid, CMU reversed the inhibition caused by high concentrations of oxygen. With ethylenediaminetetraacetic acid (EDTA), tetraethylene tetramine, or Mn(++) as reductant, CMU itself inhibited the reactions. The photoreduction of flavins by EDTA and the bleaching of flavin mononucleotide under anaerobic conditions were also inhibited by CMU. Corresponding photoreactions sensitized by phthaleine dyes or methylene blue were completely insensitive to CMU. This compound therefore seems to change specifically the reactivity of excited flavin molecules.


BRADYKININ: VASCULAR RELAXANT, CARDIAC STIMULANT. Bradykinin infusion causes an increase in cardiac output in rats whether the autonomic nervous system is blocked or not. After autonomic blockade, bradykinin causes a lesser decrease in the total peripheral resistance but a greater increase in cardiac output, resulting in an elevation of arterial pressure. The increase in cardiac output is caused by a small increase in heart rate and a substantial increase in stroke volume. The fact that these increases are observed after autonomic blockade suggests that bradykinin increases cardiac output by direct stimulation of the heart.


REDUNDANCY AND BIOLOGICAL AGING.

REDUNDANCY AND BIOLOGICAL AGING. The relationship between aging and organizational redundancy in biological systems was investigated from the standpoint of information theory. A mortality rate function derived for a randomly deteriorating redundant system approximates observed mortality rates more closely than does the Gompertz function and indicates that variations in redundancy among various mammalian species could account for their widely different rates of aging.


CINERADIOANGIOGRAPHIC VISUALIZATION  OF THE VENOUS DRAINAGE OF THE PRIMATE PLACENTA IN VIVO. Radiopaque dye injected directly into the intervillous space of the placenta of the rhesus monkey may be observed, by cineradiography, as it spreads throughout the space and drains into the veins of the uterine wall and eventually into the systemic circulation.


NUCLEAR BODIES: THEIR PREVALENCE, LOCATION, AND ULTRASTRUCTURE  IN THE CALF. Nuclear bodies, averaging 0.8 to 1.2micro in diameter, were observed in various parenchymatous and interstitial cells of the calf. They were most prevalent and complex in structure in the parenchymatous cells of the adrenal cortex, and consisted of a fibrillar outer portion and a central or core area of varying size that was composed of electron-opaque particulate matter. These bodies, as far as the authors are aware, are of unknown significance.


UNMINERALIZED FOSSIL BACTERIA.

UNMINERALIZED FOSSIL BACTERIA. Unmineralized bacterial cells, mostly Micrococcus sp., but including also Streptococcus sp. and Actinomyces sp., were found in enormous numbers in lake beds of the Newark Canyon Formation of Early Cretaceous age, Eureka County, Nevada. The micrococci are black, and have an average diameter about 0.5 micro. Similar black micrococci (0.4 to 0.7 micro) were found in profusion in the bottom mud of Green Lake, New York. About 80 percent of this mud consists of minute idiomorphic calcite crystals and about 20 percent of these contain enormous numbers of the black micrococci. It is suggested that the Early Cretaceous bacterial cells owe their preservation to occlusion in calcite crystals that grew in a black, bacterial mud in a meromictic lake in which part of the Newark Canyon Formation accumulated.


ISOLATION OF A VIRAL AGENT  FROM PSEUDOCOWPOX DISEASE. A virus with characteristics similar to the pox group was isolated in tissue culture from bovine skin and oral lesions typical of pseudocowpox. The properties of this agent, certain of which differ from vaccinia virus, suggest that the isolate is the etiologic agent of the pseudocowpox syndrome.


SUCROSE: PRECISE DETERMINATION OF CRYSTAL AND MOLECULAR STRUCTURE  BY NEUTRON DIFFRACTION. This analysis provides the first precise molecular parameters for sucrose. All hydrogen atoms are included. Carbon-carbon distances are 1.51 1.53 A; carbon-oxygen 1.40 to 1.44 A; carbon-hydrogen 1.08 to 1.11 A; oxygen-hydrogen 0.94 to 0.99 A. The furanose ring conformation differs from that in sucrose sodium bromide dihydrate. Hydrogen bonds (two of them intramolecular) utilize every hydroxyl group except one.


SKIN IMPEDANCE AND PHASE ANGLE AS A FUNCTION OF FREQUENCY AND  CURRENT. The impedance of the human skin decreased from approximately 130 to 30 Kohm as the frequency of a-c input increased from 1 to 1000 cycles per second. Over this same range of frequencies, the phase angles changed from -2 to -58 degrees. Changing the peak-to-peak current through the subject from 14 to 62 microamperes had no effect or the phase angles.


STARTLE REACTION: MODIFICATION BY BACKGROUND ACOUSTIC  STIMULATION. Six rats were exposed to a sequence of gunshot-like acoustical bursts during silence, during steady noise, and during pulsed noise. Assessment of their startle reactions to the bursts revealed that a background of steady noise enhanced the response, whereas a background of pulsed noise produced suppression of response. It is hypothesized that pulsed noise causes a relative refractory state in the mechanisms responsible for startle and that steady noise may enhance startle by masking uncontrolled punctiform acoustic stimuli.


PULMONARY EDEMA AS A CONSEQUENCE OF HYPOTHALAMIC LESIONS IN RATS. Rats were observed for the incidence of pulmonary edema after the placement of hypothalamic lesions by radio frequency thermocoagulation or d-c electrolysis. In the animals with electrolytic lesions, 31 percent died with pulmonary edema and marked signs were observed in another 20 percent. Moderate transient signs appeared in only 3.7 percent of the animals with radio-frequency lesions, and there were no deaths attributable to this syndrome in this group. These results suggest that this syndrome is an irritative consequence of the electrolytic lesion process rather than a "release" phenomenon.


SLEEP: CORTICAL AND SUBCORTICAL RECORDINGS IN THE  CHIMPANZEE. Etectroencephalographic sleep patterns of chimpanzees reveal greater similarities to human records than those of lower mammals. Flash-evoked responses in the midbrain reticular formation remain during "paradoxical" sleep, which does not appear to necessarily involve deep unconsciousness. Characteristic spindling occurs in the amygdala during a "paradoxical" type sleep while other areas were desynchronized. Telencephalic sleep-control mechanisms in higher primates are considered.


GAMMA-EMITTING  RADIONUCLIDES IN NEWBORNS, INFANTS, AND CHILDREN. During the period April 1962 to April 1963, 28 newborn infants, 7 stillborns, and 21 children from 4 to 15 years of age were examined for emission of gamma activity in a low-background, high-sensitivity, total-body counting facility. The 21 children contained traces of combined Zr(95) and Nb(95), Ru(103), (106), and Cs(137) in addition to the normal K(40). The greatest concentration of Cs(137) observed was 80 picocuries per kilogram of body weight, or about 4 percent of the natural K(40) radioactivity. Four of the seven stillborns, each counted for 10 hours, shoWed K(40) and traces of Zr(95), Nb(95), and Ru(103), (106). The ratios of Zr(95) to Nb(95) were lower in the stillborns than in their placentas which suggested placental discrimination against Zr(95). The ratios of Cs(137) to K(40) were lower in infants than in children or adults. Thyroid glands obtained atautopsy from 24 infants during April to September 1962 contained no detectable radioiodine ( less than 30 pc).


RIBOSOMAL RNA ON THE SURFACE OF RIBOSOMES. Ribonuclease from pancreas releases nucleotide from Escherichiacoli ribosomes while not altering significantly the base composition of the total ribosomal RNA. Ribonuclease hydrolyzes ribsomal RNA without destroying the structure of 70S or 30S and 50S ribosomes. The RNA in 30S and 50S ribosomes appears more sensitive to the action of ribonuclease. The data suggest that RNA may be a surface component of the ribosome.


REDUCTIVE DECHLORINATION OF DDT TO DDD BY YEAST. Labeled DDD [ 1,1-dichlor-o-2,2-bis(p-chlorophenyl)-ethane] was formed from C(14)-labeled DDT in the presence of yeast. The formation of DDD from DDE [1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene] was not observed, indicating that a reductive dechlorination of DDT occurs.


VIRUS AS A MUTAGENIC AGENT IN MAIZE.

VIRUS AS A MUTAGENIC AGENT IN MAIZE. Evidence indicating that barley-stripe-mosaic virus has a mutagenic effect on maize is presented. The frequency of deficiencies of marker genes in F(1) seeds was significantly greater from pollinations involving viruis-infected males than from healthy controls. A small percentage of F(2) ears, involving virus-infected P(1) males, exhibited marked ratio distortions for marker genes. Such distortions persisted in subsequent back-cross generations.


REGULATION OF ENZYME ACTIVITY BY SPECIFIC  REVERSAL OF FEEDBACK INHIBITION. Studies with a photosynthetic bacterium have revealed a novel type of regulatory control of enzymes participating in amino acid biosyntheses. Feeback inhibition of enzyme activity can be specifically reversed by ultimate end products of a branched pathway.


ABERRANT THYROID TISSUE IN THE MOUSE.

ABERRANT THYROID TISSUE IN THE MOUSE. Aberrant thyroid tissue was observed at the base of the heart in seven of 2634 mice of the BALB/c strain. Such tissue was not seen in any of 1033 mice of the Strong A strain. The normal thyroid gland of the BALB/c mouse was observed to be more loose than that of the Strong A mouse and isolated follicles were frequently observed in tissue sections at either pole of the gland which were not attached to the body of the thyroid.


ELASTICITY OF ARTICULAR CARTILAGE: EFFECT OF IONS AND VISCOUS SOLUTIONS. The deformability of articular cartilage is increased by cations, more so by polyvalent than monovalent ones. Trivalent cations also depress elastic recovery. Failure of viscous solutions to alter the elastic behavior suggests ultra-filtration by cartilage as a possible mechanism in synovial lubrication.


TANNING IN THE ADULT FLY: A NEW FUNCTION OF NEUROSECRETION IN  THE BRAIN. Tanning in the newly emerged fly is induced by a hormone secreted by neurosecretory cells situated in the pars intercerebralis of the brain. The same hormone is contained in the compound ganglion of the thorax, in concentrations six times as high as in the brain. This hormone is believed to act directly on the eflector organ, and not through the secretion of ecdyson or a corpus allatum hormone; its release is effected through nervous impulses reaching the brain by way of the ventral nervous system a few minutes after the fly has emerged from the puparium. The hormone appears to be different from both the prothoraco-tropic and the gonadotropic hormones.


ISOLATION OF THE MONKEY BRAIN: IN VITRO PREPARATION  AND MAINTENANCE. Sustained viability of the primate brain, as a totally isolated organ preparation, was achieved by utilizing an extracorporeal (compatible donor) circulation. Five rhesus monkey brains, completely isolated neurogenically and vascularly, were perfused in vitro for 30 to 180 minutes. Retention of biological activity was evidenced by: (i) persistent electrocortical activity, and (ii) significant mean A-Vo(o2) (5.8 volumes percent) and V-Aco(co2) (5.0 volumes percent) differences across the isolated brain.


CIRCULATING INTERFERON IN MICE AFTER INTRAVENOUS INJECTION OF  VIRUS. Circulating interferon was detectable in mouse serum within 1 hour after the intravenous injection of various types of virus and it reached maximum levels in about 4 hours. Rapidly produced interferon may play a role in the pathogenesis of viral infection and in viral interference.


ACTINOMYCIN D EFFECTS IN FROG EMBRYOS: EVIDENCE FOR SEQUENTIAL SYNTHESIS  OF DNA-DEPENDENT RNA. Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.


INFORMATION STORAGE REQUIREMENTS FOR THE CONTENTS OF THE WORLD'S LIBRARIES. Three calculations of the number of different things stored in the world's libraries yield estimates from 7.5 x 10(7) to 7.7 x 10(8). At 10(5) words per volume, five letters per word, and 12 bits per letter, the information capacity used for storage is between 4.6 x 10(14) and 4.6 x 10(15) bits, and is increasing at about 2 x 10(6) bits per second.


STREPTOMYCIN AS AN ANTIVIRAL AGENT: MODE OF ACTION. In host bacteria resistant to the antibiotic, streptomycin inhibits phage replication by inhibiting the process of injection. This effect is competitively reversed by certain divalent cations, polyamines, and streptidine. It is proposed that streptomycin inhibits injection by attaching to the phage DNA while it is still folded within the phage head, and in this way it prevents the unfolding which is essential for the injection process. The reversal agents probably function by displacing the antibiotic from the phage, but they also promote injection themselves.


THE NEW REGULATIONS PERTAINING TO RESEARCH GRANTS OF THE PUBLIC HEALTH  SERVICE.


PHOSPHOHISTIDINE.

PHOSPHOHISTIDINE.


ORIENTAL RENAISSANCE IN EDUCATION AND MEDICINE.


RELATIVE DATING OF ARLINGTON SPRINGS MAN. Relative dating tests confirm the antiquity of the Arlington Springs human femur.


TEMPERATURE-DEPENDENT HISTOTYPIC CHANGES IN WALKER  CARCINOSARCOMA IN THE CHORIOALLANTOIS. Solid tumors grew in the chorioallantois of chick embryos after the topical inoculation of ascites tumor cells. The microscopic character of the growth varied depending on the temperature of incubation. At 32.5 degrees C a sarcomatous appearance was prominent; at 37.5 degrees C carcinomatous structure in several alveolar patterns predominated; at 42.5 degrees C growth was that of a "giant cell" carcinoma.


THERMALLY INDUCED GENITAL APPENDAGES ON MOSQUITOES. Temperatures above those normally present in larval sites of certain mosquitoes (for example, Aedes stimulans) cause larvae of potential males to be feminized in all degrees. Certain combinations of temperatures will affect these larvae so that an abnormal pair of genital appendages consistently appears in addition to the usual pair. These appendages appear to be masculine and are presumed to come from imaginal discs that are latent in present-day Diptera.


STRESS MODIFICATION OF DRUG RESPONSE.

STRESS MODIFICATION OF DRUG RESPONSE. Rats stressed by unilateral hind-leg ligation show a significantly decreased pharmacological response to the effects of hexobarbital, meprobamate, and pentobarbital. This effect is dependent upon an intact pituitaryadrenal axis, since it is absent in both hypophysectomized and adrenalectomized animals. It can be simulated by intravenous administration of adrenocorticotrophic hormone or corticosterone. The effect of stress on drug response is not noted with barbital, a compound which is not metabolized; this effect is inhibited by treatment of the animal with a drug metabolism inhibitor such as SKF 525-A (diethylaminoethyl 2,2-diphenylpentanoate). Compounds which can stimulate adrenocorticotrophic hormone secretion or act directly on the adrenals to produce corticosteroids should thus be able to stimulate their own metabolism or that of other drugs.


RIBOSOMAL RNA IN THE DEVELOPING CHICK  EMBRYO. Developing chick embryos from the stage of primitive-streak formation make ribosomal (28S and 16S) RNA. The size and composition of the RNA appears to be constant throughout the first 7 days of development.


TREMORINE: ITS EFFECT ON AMINES OF THE CENTRAL  NERVOUS SYSTEM. The administration of tremogenidine doses of Tremorine, 1,4-dipyrrolidino-2 butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in norepinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of S-hydroxytryptamine.


ANTIGENIC HISTAMINE RELEASE FROM PASSIVELY  SENSITIZED HUMAN LEUDOCYTES. With histamine release as an indicator, consistent passive sensitization of normal human leukocytes to specific anligen could be achieved with human serum, fresh or stored at -70 degrees C, from allergic individuals. With certain sera, dilution slowed the rate of sensitization but increased eventual histamine release.


CARBOHYDRATE DIGESTION IN THE COCKROACH. The digestive tract of the cockroach, Blaberus craniifer Burmeister, contains amylase, alpha- and beta-glucosidases, beta-fructofuranosidase, alpha- and beta-galactosidases, but no cellulase. The most active site of hydrolytic action is the midgut, followed by the foregut, hindgut, salivary gland tissue, and Malpighian tubules.


THYMECTOMY: PROLONGATION OF IMMUNOLOGICAL TOLERANCE IN THE ADULT  MOUSE. The loss of acquired immunological tolerance of mice to bovine gamma globulin depended on the presence of the thymus. Mice were repeatedly injected with bovine gamma-globulin from birth until the age of 5 to 10 weeks and then thymectomized or sham operated. After 130 to 160 days without antigen, an accelerated (immune) disappearance of I(125) bovine gamma-globulin could be uniformly induced in controls while thymectomized mice remained tolerant. Adult thymectomized mice made tolerant by a single injection of bovine gamma-globulin lost tolerance more slowly than sham-operated controls.


HETEROGENEITY OF DNA IN DENSITY AND BASE COMPOSITION. Chromatography, on methylated-albumin columns, of DNA from calf thymus, mouse testis, and Bacillus subtilis, yielded, on elution by a sodium chloride gradient, fractions differing in density. The fractions eluted by higher sodium chloride concentrations had lower densities in a CsCl density gradient. Since DNA with higher guaninecytosine content is eluted from the column with lower concentration of sodium chloride and has higher density, the density heterogeneity of DNA is best interpreted as a result of heterogeneity of base composition. An extra band observed in calf-thymus DNA had a higher density than that of the main DNA; it was eluted at a lower concentration of NaCl, indicating a higher content of guanine and cytosine. On the other hand, an additional DNA component in the mouse-testis DNA had a lower density and also it was eluted at a lower salt concentration, possibly an indication of an unusual base component in its structure.


AUDITORY DISCRIMINATION BY THE CAT AFTER  NEONATAL ABLATION OF TEMPORAL CORTEX. Some auditory discriminations cannot be acquired by the cat after large bilateral ablations of auditory cortex at maturity. However, if such ablations are sustained during infancy, these discriminations are readily learned. The function of the cortex in auditory discrimination depends on the age of the nervous system at the time of injury.


CYTOECOLOGY OF TEMPERATURE.

CYTOECOLOGY OF TEMPERATURE.


PROBLEMS OF PSYCHIATRY IN THE HIGHLANDS AND ISLANDS.


REVERSED FLOW IN THE VERTEBRAL ARTERY IN ASSOCIATION WITH SUBCLAVIAN OCCLUSION.


CULTURE AND MENTAL ILLNESS.

CULTURE AND MENTAL ILLNESS.


PASTEURELLA MULTOCIDA: HUMAN INFECTIONS.


THYROID CANCER IN CHILDHOOD.

THYROID CANCER IN CHILDHOOD.


ANTI-PROGESTATIONAL ACTIVITIES OF CERTAIN PLANT PREPARATIONS ON THE UTERINE ENDOMETRIUM.


STUDY OF FATE OF INTRACRANIAL HEMATOMA WITH RADIOACTIVE ISOTOPE FE59.


PATHOPHYSIOLOGY OF PLASMIN SYSTEM. V. PLASMIN SYSTEM AND POSTPARTUM HEMORRHAGE.


EFFECTS UPON THALAMIC SOMATOSENSORY TRANSMISSION OF RETICULAR FORMATION STIMULATION.


PAPERELECTROPHORETIC ANALYSIS OF SERUM LIPOPROTEINS OF NORMAL INFANTS AND CHILDREN.


QUANTITATIVE DETERMINATION OF 3,4-DIHYDROXYMANDELIC ACID (DOMA) IN HUMAN URINE.


BLOOD PRESSURE CHANGES FOLLOWING CLAMPING AND UNCLAMPING OF THE LOWER ABDOMINAL AORTA. EXPERIMENTAL AND CLINICAL OBSERVATIONS.


CALYCEAL DIVERTICULUM: A REPORT OF SIXTEEN CASES AND  REVIEW OF THE LITERATURE.


HISTOLOGICAL GRADING OF URINARY BLADDER TUMOURS. A STUDY OF 411 URINARY BLADDER  BIOPSIES.


A COMPARISON OF POLYOMA, "K", AND KILHAM RAT VIRUSES  WITH THE ELECTRON MICROSCOPE.


STRUCTURE OF SOME SIMIAN  ADENOVIRUSES.

STRUCTURE OF SOME SIMIAN  ADENOVIRUSES.


COUNTING OF SENDAI VIRUS PARTICLES BY AN  IMMUNOFLUORESCENT TECHNIQUE.


STRUCTURE AND COMPOSITION OF K VIRUS, AND ITS RELATION  TO THE "PAPOVAVIRUS" GROUP.


PURIFICATION AND PARTIAL CHEMICAL ANALYSIS OF SINDBIS VIRUS.


THE SOURCE OF THE RIBONUCLEIC ACID AND PHOSPHOLIPID OF  SINDBIS VIRUS.


A STUDY ON DISSOCIATION OF COXSACKIE B4 VIRUS-ANTIBODY COMPLEX.


ACTIVATION OF LATENT VIRUS INFECTION BY HEAT.


PURIFICATION OF VESICULAR STOMATITIS VIRUS AND THE ANALYSIS OF  P32-LABELED VIRAL COMPONENTS.


TRANSLOCATED WOUND STIMULI AFFECTING PLANT VIRUS INFECTIONS.


SUSCEPTIBILITY OF AN INSECT TISSUE CULTURE TO INFECTION BY  VIRUS PREPARATIONS OF THE NUCLEAR POLYHEDROSIS OF THE SILKWORM (BOMBYX MORI L.).


THE BEHAVIOUR OF SOME TOBACCO NECROSIS VIRUS STRAINS IN PLANTS.


THERMAL INACTIVATION OF TOBACCO NECROSIS VIRUS.


AN EXTRACTABLE AGENT, INDUCED IN UNINFECTED TISSUES BY LOCALIZED  VIRUS INFECTIONS, THAT INTERFERES WITH INFECTION BY TOBACCO MOSAIC VIRUS.


INHIBITION OF INFLUENZA VIRUS HAEMAGGLUTINATION: A  DIFFERENCE OF BEHAVIOR IN SERA FROM A SINGLE SPECIES.


PURIFICATION AND ELECTRON MICROSCOPY OF PANTROPIC RIFT VALLEY  FEVER VIRUS.


INHIBITION BY  20-METHYLCHOLANTHRENE OF INTERFERON PRODUCTION IN RAT CELLS.


DIFFERENCES AMONG THE SOLUBLE ANTIGENS OF MYXOMA  VIRUSES ORIGINATING IN BRAZIL AND IN CALIFORNIA.


GENETIC RESISTANCE TO ROUS SARCOMA VIRUS IN EMBRYO  CELL CULTURES AND EMBRYOS.


SMALLPOX TODAY.

SMALLPOX TODAY.


CHILDREN IN DAY-CARE CENTRES AND INSTITUTIONS.


THE TEACHING OF PSYCHIATRY IN THE WORLD.


HEALTH EDUCATION IN THE USSR.

HEALTH EDUCATION IN THE USSR.


SOMALI TRIBESMEN AND HEART DISEASE.

SOMALI TRIBESMEN AND HEART DISEASE.


ABNORMALITIES IN EEG RECORDINGS FROM ACTIVELY SENSITIZED ANIMALS WITHOUT CLOSE CORRELATION TO ANAPHYLACTIC RESPONSE.


AIR POLLUTION AND ALLERGY.

AIR POLLUTION AND ALLERGY.


A COMPARISON BETWEEN THE SUMMER AND AUTUMN AIR-SPORAS AT LONDON AND LIVERPOOL.


IMMUNOELECTROPHORESIS AS A DIAGNOSTIC MEANS IN ALLERGIC DISORDERS.


PASSIVE TRANSFER OF ALLERGIC ECZEMATOUS CONTACT-TYPE SENSITIVITY.


SENSITIVITY TO DEER SCURF.

SENSITIVITY TO DEER SCURF.


[IN MEMORY OF DR. KARL HANSEN (1893-1962)].


EXPERIMENTAL ASTHMA OF THE GUINEA-PIG INDUCED BY BRONCHIAL SPUTUM.


THE EFFECT OF STALK SECTION ON THE VOLUME OF THE PITUITARY GLAND OF THE SHEEP.


SPECTROPHOTOMETRIC DETERMINATION OF HB M-IWATE IN THE HEMOLYSATE OF HEREDITARY NIGREMIA.


HEMOLYTIC DISEASE ASSOCIATED WITH  THE PRODUCTION OF ABNORMAL HEMOGLOBIN AND INTRAERYTHROCYTIC HEINZ BODIES.


STUDIES ON ERYTHROPOIETIN. III. ISOLATION OF ERYTHROPOIETIN FROM CERULOPLASMIN MOLECULE.


BIOCHEMICAL REACTIONS AND VIRULENCE OF E. COLI O124: K72 (17).


CORRELATION BETWEEN PHAGE-TYPE, COAGULASE, HYALURONIDASE AND PHOSPHATASE ACTIVITY, AND MERCURIC CHLORIDE RESISTANCE OF STAPHYLOCOCCUS AUREUS.


IMMUNOFLUORESCENCE AND PASSIVE HAEMAGGLUTINATION IN INFANTILE ENTEROCOLITIS.


ADAPTATION OF YEASTS TO DISINFECTANTS.

ADAPTATION OF YEASTS TO DISINFECTANTS.


STUDIES ON THE AETIOLOGY OF EPIDEMIC KERATOCONJUNCTIVITIS OBSERVED IN BUDAPEST DURING WINTER, 1961--1962.


SUPPLEMENTED PHAGE-TYPING OF SALOMONELLA TYPHI MURIUM AND ITS USE IN EPIDEMIOLOGY.


ACCIDENTAL LABORATORY INFECTIONS BY ADENOVIRUS TYPE 8.


AETIOLOGIC RELATIONSHIP OF ADENOVIRUS TYPE 8 TO THE EPIDEMIC OF KERATOCONJUNCTIVITIS IN SZEGED.


OLIGOSACCHARIDE DECOMPOSITION BY CANDIDA SOLANI.


ON THE ACTION OF LINEAR ACCELERATIONS UPON THE OTOLITHS.


INTESTINAL TRANSPORT OF MONOSACCHARIDES IN GENERALIZED AND  SELECTIVE MALABSORPTION.


PSEUDOCROUP. A 30-YEAR SERIES FROM LUND.


AN APPARATUS FOR CONTINUOUS DIRECT AND INDIRECT  CALORIMETRIC ESTIMATIONS OF NEWBORNS AND PREMATURES UNDER DIFFERENT ENVIRONMENTAL CONDITIONS.


MEDICAL TREATMENT OF HABITUAL VOMITING.

MEDICAL TREATMENT OF HABITUAL VOMITING.


MEMBRANOUS STOMATITIS IN SWEDEN 1956-1961.


SOME REFLECTIONS ON JUVENILE DIABETES AND ITS TREATMENT.


ALLERGIC CHILDREN WITH VARIOUS SYMPTOMS CAUSED BY  COW'S MILK.


THE SIGN OF THE PULSATING CANDLE-LIGHT.

THE SIGN OF THE PULSATING CANDLE-LIGHT.


TREATMENT OF MICROGNATHIA.

TREATMENT OF MICROGNATHIA.


EXTRACARDIAC CONGENITAL MALFORMATIONS IN  CHILDREN WITH CONGENITAL HEART DISEASES.


ANOREXIA AND BRAIN TUMOUR. REPORT OF TWO CASES.


TRANSPLACENTAL METASTASIS OF MALIGNANT MELANOMA. REPORT OF A CASE.


STUDY OF SYSTOLIC BLOOD PRESSURE, HEART RATE, BODY TEMPERATURE OF  NORMAL NEWBORN INFANTS THROUGH THE FIRST WEEK OF LIFE.


VITAMIN E TO PREMATURE INFANTS. INFLUENCE ON SERUM BILIRUBIN,  HEMOGLOBIN AND ALKALINE PHOSPHATASE.


FLUID    AND ELECTROLYTE METABOLISM IN NEPHROGENIC DIABETES INSIPIDUS.TWO CASES.


NORMAL CONDUCTION VELOCITY OF ULNAR, MEDIAN AND PERONEAL NERVES IN INFANCY,  CHILDHOOD AND ADOLESCENCE.


MONGOLISM AND OTHER ABNORMALITIES IN A FAMILY WITH TRISOMY 21-22 TENDENCY.


ENZYME ACTIVITY IN CULTURED CELLS UNDER VARIOUS INFLUENCES. A CYTOCHEMICAL APPROACH.


ON THE INFLUENCE OF CERTAIN HORMONES ON THE TISSUE COMPONENTS OF THE TUBERCULOTIC LYMPH NODE. AN EXPERIMENTAL STUDY ON GUINEA-PIGS BY THE LINE SAMPLING METHOD.


PANEL DISCUSSION ON RECENT ADVANCES IN MANAGEMENT OF BILIARY TRACT PROBLEMS.


ROENTGENOGRAPHIC DEMONSTRATION OF A GIANT CONGENITAL CYST OF THE LIVER.


RELATIONSHIPS BETWEEN HEPATIC AND PANCREATIC FUNCTION.


ACUTE GASEOUS CHOLECYSTITIS. A CASE REPORT.


MODIFICATION OF SENGSTAKEN TUBE FOR SIMULTANEOUS LOCAL ESOPHAGEAL PRESSURE AND HYPOTHERMIA. AN ANIMAL STUDY.


OBSTRUCTING CARCINOMA WITH ACUTE PROXIMAL ULCERATIVE COLITIS.


RETICULUM CELL SARCOMA OF THE SMALL INTESTINE DIAGNOSED BY PERORAL INTESTINAL BIOPSY. REPORT OF A CASE.


ON THE CORRELATION BETWEEN THE NATURE AND ANTIBIOTIC SENSITIVITY OF THE BACTERIAL FLORA OF THE AIR AND CONTAMINATION OF HOSPITAL ROOMS.


CALIFORNIA ENCEPHALITIS VIRUS. SEROLOGIC SURVEY OF SMALL WIND MAMMALS IN NORTHERN UNITED STATES AND SOUTHERN CANADA AND ISOLATION OF ADDITIONAL STRAINS.


THE CUTTER INCIDENT. POLIOMYELITIS FOLLOWING FORMALDEHYDE-  INACTIVATED POLIOVIRUS VACCINATION IN THE UNITED STATES DURING THE SPRING OF 1955. I. BACKGROUND.


Q FEVER VACCINATION OF HUMAN VOLUNTEERS. I. THE SEROLOGIC AND SKIN-TEST RESPONSE FOLLOWING SUBCUTANEOUS INJECTIONS.


THE CUTTER INCIDENT. POLIOMYELITIS FOLLOWING FORMALDEHYDE-  INACTIVATED POLIOVIRUS VACCINATION IN THE UNITED STATES DURING THE SPRING OF 1955. II. RELATIONSHIP OF POLIOMYELITIS TO CUTTER VACCINE.


STUDIES ON MIXED INFECTION WITH POLIOVIRUS TYPE 1 AND ECHO VIRUS TYPE 7 IN MONKEYS AND CELL CULTURES.


COATS' DISEASE.

COATS' DISEASE.


SURGICAL TREATMENT OF RETINAL CYSTS.

SURGICAL TREATMENT OF RETINAL CYSTS.


A POSTOPERATIVE PNEUMOGRAPHIC MONITORING UNIT.


RETINAL FINDINGS ASSOCIATED WITH SERUM HYPERVISCOSITY.


PERFORMANCE OF AN ADJUSTABLE HEART SUBSTITUTE.


AN ELECTRONIC-MECHANICAL CONTROL FOR AN INTRATHORACIC ARTIFICIAL HEART.


STEROID THERAPY AND SECONDARY GLAUCOMA.

STEROID THERAPY AND SECONDARY GLAUCOMA.


SEPTIC THROMBOSIS WITHIN THE CAVERNOUS CHAMBER. REVIEW OF THE  LITERATURE WITH RECENT ADVANCES IN DIAGNOSIS AND TREATMENT.


CLINICAL EXPERIENCES WITH A SEMIAUTOMATIC BLOOD VOLUME APPARATUS.


HISTOPATHOLOGY OF EXPERIMENTAL PHOTOCOAGULATION IN THE DOG EYE. III. MICROANEURYSMLIKE FORMATIONS FOLLOWING BRANCH VEIN OCCLUSION.


A CONSTANT CURRENT RADIOFREQUENCY COAGULATOR FOR PRODUCING LESIONS IN NERVOUS TISSUE.


BLOWOUT FRACTURES ON THE ORBITAL FLOOR. THE USE OF A STENT IN THEIR REPAIR.


CHORIORETINITIS AND HYDROCEPHALUS.

CHORIORETINITIS AND HYDROCEPHALUS.


SUPPORT FOR RESEARCH, TRAINING AND EDUCATION IN MEDICAL ELECTRONICS.


THE EFFECT OF A CONTACT LENS ON THE CONTENT OF CARBON DIOXIDE IN THE AQUEOUS HUMOR.


ADRENOCORTICOTROPHIC HORMONE RESERVE OF THE ANTERIOR PITUITARY GLAND AFTER SEVERE POSTPARTUM HAEMORRHAGE.


SURGICAL TREATMENT OF THE POSTCHOLECYSTECTOMY SYNDROME.


SOVIET MEDICAL ENGINEERING.

SOVIET MEDICAL ENGINEERING.


ANTICIPATED BIOLOGICAL AND ENVIRONMENTAL EFFECTS OF DETONATING A TWENTY-  MEGATION WEAPON ON COLUMBUS CIRCLE IN NEW YORK CITY.


THE INTERPROFESSIONAL TREATMENT OF THE DISTURBED AND DELINQUENT ADOLESCENT. CONTRIBUTION OF MEDICAL AND NURSING ASPECTS OF RESIDENTIAL TREATMENT.


THE INTERPROFESSIONAL TREATMENT OF THE DISTURBED AND DELINQUENT ADOLESCENT. TREATMENT MILIEU: INTERDISCIPLINARY APPROACHES.


THE INTERPROFESSIONAL TREATMENT OF THE DISTURBED AND DELINQUENT ADOLESCENT. INDIVIDUAL PSYCHOTHERAPY IN RESIDENTIAL TREATMENT AT HAWTHORNE CEDAR KNOLLS SCHOOL.


ON ERICH NASSAU'S LIFE.

ON ERICH NASSAU'S LIFE.


PULMONARY ALVEODAR MICROLITHIASIS.

PULMONARY ALVEODAR MICROLITHIASIS.


INVESTIGATION OF DRUG SENSITIVITY IN SHIGELLA AND ITS CORRELATION WITH "IN VIVO" SENSITIVITY.


EXPERIMENTAL PAIN FROM THE HIP-JOINT.

EXPERIMENTAL PAIN FROM THE HIP-JOINT.


CAVITATION OF A RHEUMATOID LUNG NODULE.

CAVITATION OF A RHEUMATOID LUNG NODULE.


THE SURGERY OF RHEUMATOID ARTHRITIS.

THE SURGERY OF RHEUMATOID ARTHRITIS.


RECENT DEVELOPMENTS IN FUNCTIONAL BRACING OF THE UPPER EXTREMITIES.


HIP INVOLVEMENT IN RHEUMATOID ARTHRITIS.


DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS BY ELECTROPHORESIS.


GENETIC FACTORS IN GENERALIZED OSTEO-ARTHROSIS.


ELECTRON MICROSCOPIC STUDY ON SEVERAL CHARACTERISTIC CELLS IN CHILDREN'S DISEASES. 2. AN ELECTRON MICROSCOPIC STUDY OF LEUKEMIC CELLS IN ACUTE LYMPHATIC LEUKEMIA IN CHILDREN.


RUBELLA SYNOVITIS.

RUBELLA SYNOVITIS.


AMYLOIDOSIS IN RHEUMATOID ARTHRITIS INVESTIGATED BY MEANS OF RECTAL BIOPSY.


AMINO-ACID CONTENT OF SERUM IN RHEUMATOID ARTHRITIS.


RELATIONSHIP OF SYSTEMIC LUPUS ERYTHEMATOSUS TO RHEUMATOID ARTHRITIS, DISCOID LUPUS ERYTHEMATOSUS, AND SJOEGREN'S SYNDROME: A CLINICAL STUDY.


RESPIRATORY DISTURBANCES CAUSED BY GENERAL SURGICAL OPERATIONS.


TISSUE TRANSPLANTATION: CIRCULATING ANTIBODY IN THE HOMOTRANSPLANTATION OF KIDNEY AND SKIN.


ONCOGENIC VIRUSES (WITH PARTICULAR REFERENCE TO MOUSE LEUKAEMIA).


CUTANEOUS EFFECTS OF HOUSEHOLD SYNTHETIC DETERGENTS AND SOAPS.


THE HOUSEWIFE AND HER EXPOSURE TO WASHING PRODUCTS.


SOLAR URTICARIA.

SOLAR URTICARIA.


MELORHEOSTOSIS WITH LINEAR SCLERODERMA.

MELORHEOSTOSIS WITH LINEAR SCLERODERMA.


VOGT-KOYANAGI-HARADA SYNDROME.

VOGT-KOYANAGI-HARADA SYNDROME.


CANDIDA GRANULOMA WITH  EPIDERMOPHYTOSIS. REPORT OF A CASE AND REVIEW OF THE LITERATURE.


SWIMMING POOL GRANULOMA. A STUDY OF 290 CASES.


MULTIPLE PAPULAR FACIAL GRANULOMAS WITH EOSINOPHILIA.


BASAL CELL EPITHELIOMA AND CHRONIC RADIODERMATITIS.


HODGKIN'S DISEASE CONCURRENT WITH URTICARIA PIGMENTOSA.


LUPUS ERYTHEMATOSUS AND ERYTHEMA MULTIFORME-LIKE LESIONS. A SYNDROME WITH CHARACTERISTIC IMMUNOLOGICAL ABNORMALITIES.


ONYCHOLYSIS. A CLASSIFICATION AND STUDY.


THE DISTAL COURSE OF NAIL MATRIX HEMORRHAGE.


URTICARIA AND ASTHMA FROM ACETYLENE WELDING.


CATARACTS IN ALOPECIA AREATA. REPORT OF FIVE CASES.


ALOPECIA UNIVERSALIS, ONYCHODYSTROPHY, AND TOTAL VITILIGO.


HYPERKERATOSIS PALMOPLANTARIS WITH PERIODONTOSIS (PAPILLON-LEFEVRE).


HYPERKERATOSIS PENETRANS (KYRLE'S DISEASE).


SYMMETRY IN ELASTOSIS PERFORANS SERPIGINOSA. ITS SIGNIFICANCE.


SEVERE REACTION TO GRISEOFULVIN.

SEVERE REACTION TO GRISEOFULVIN.


LOUIS SCHWARTZ, MD, 1883-1963.

LOUIS SCHWARTZ, MD, 1883-1963.


CAPILLARY MICROSCOPY IN INDUCED SKIN INFLAMMATION.


REACTIONS TO LIGHT IN YELLOW TATTOOS FROM CADMIUM SULFIDE.


STUDIES ON PITYRIASIS ALBA. A COMMON FACIAL SKIN LESION IN EGYPTIAN CHILDREN.


TRAUMA IN EXPERIMENTAL SUPERFICIAL CUTANEOUS INFECTIONS.


CHLOROQUINE. A REVIEW OF REACTIONS AND DERMATOLOGIC INDICATIONS.


ALOPECIA AREATA. AN EVALUATION OF 736 PATIENTS.


DEMODEX FOLLICULORUM AND BLEPHARITIS.

DEMODEX FOLLICULORUM AND BLEPHARITIS.


HYPERTHYROIDISM, PRETIBIAL MYXEDEMA, AND CLUBBING. REVIEW OF SYNDROME AND REPORT OF A CASE TREATED LOCALLY WITH TSH AND TRIIODOTHYRONINE.


MULTIPLE NONPIGMENTED NEVI IN A NEGRO CHILD. POSSIBLE RELATIONSHIP TO LEUKODERMA ACQUISITUM CENTRIFUGUM (HALO NEVUS).


VULVAR VON RECKLINGHAUSEN'S DISEASE.

VULVAR VON RECKLINGHAUSEN'S DISEASE.


ZOSTER CAUSING VARICELLA. CURRENT DANGERS OF CONTAGION WITHOUT ISOLATION.


CANDIDA CHEILITIS.

CANDIDA CHEILITIS.


CATARACTS ASSOCIATED WITH DERMATOLOGIC DISORDERS.


DYSKERATOSIS CONGENITA. FIRST REPORT OF ITS OCCURRENCE IN A FEMALE AND A REVIEW OF THE LITERATURE.


FUNGUS INFECTIONS OCCURRING UNDER OCCLUSIVE DRESSINGS.


POSITIVITY OF THE METHYLENE BLUE TEST IN XANTHOMATOSIS.


SMOOTH MUSCLE-CONTRACTING PEPTIDE FROM THE RABBIT PLACENTA AND ITS COMPARISON TO BRADYKININ.


RELATIVE TOXICITY OF CHLORTETRACYCLINE AND SODIUM BENZOATE AFTER ORAL ADMINISTRATION TO RATS.


RADIOMETRIC QUANTITATION OF THE INHIBITION OF 5-HYDROXYTRYPTAMINE-  INDUCED EDEMA IN MICE.


STUDIES ON MORPHINE. I. EFFECTS OF NALORPHINE AND LEVALLORPHAN IN MICE IMPLANTED WITH PELLETS OF MORPHINE.


STUDIES ON MORPHINE. II. REPEATED ADMINISTRATION OF NALORPHINE TO WHITE MICE CHRONICALLY TREATED WITH PELLETS OF MORPHINE.


THE CARRAGEENIN-INDUCED ABSCESS AS A NEW TEST FOR ANTI-INFLAMMATORY ACTIVITY OF STEROIDS AND NONSTEROIDS.


EFFECT OF COMPOUNDS ON BLOOD PRESSURE AND BEHAVIORAL RESPONSES OF RATS CHRONICALLY SUBJECTED TO AN AVOIDANCE-ESCAPE SITUATION.


ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION.


A THREE-STAGE SEQUENTIAL SCREENING PROGRAM FOR THE DETECTION OF ANTI-INFLAMMATORY AGENTS USING A CARRAGEENIN-INDUCED ABSCESS.


INFLUENCE OF CHLOROTHIAZIDE, HYDROCHLOROTHIAZIDE AND ACETAZOLAMIDE ON NEUROMUSCULAR TRANSMISSION IN MAMMALS.


A SEQUENTIAL PLAN FOR SCREENING COMPOUNDS WITH POTENT DIURETIC ACTIVITY IN RATS.


A SIMPLE CAGE DESIGN FOR SCREENING DIURETIC COMPOUNDS IN RATS.


THE EFFECT OF SOME SUBSTANCES ON THE ELIMINATION OF TRICHLOROETHYLENE METABOLITES.


BEHAVIOURAL AND PHARMACOLOGICAL STUDIES OF A TRANQUILISING FRACTION FROM THE OIL OF CELASTRUS PANICULATUS (MALKANGUNI OIL).


THE ACUTE ORAL TOXICITY OF SODIUM CHLORIDE.


BETA-(N-PYRROLIDYL)-BUTYROANILID (WS 10): ITS SUBACUTE TOXICITY, INFLUENCE ON MORPHINE ANALGESIA IN THE RAT AND MORPHINE ANALGESIA AND RESPIRATORY DEPRESSION IN THE RABBIT.


THE CLINICAL DISCERNMENT OF MUSCLE WEAKNESS.


PHYSICAL MEDICINE ON THE SS HOPE.

PHYSICAL MEDICINE ON THE SS HOPE.


THE USE OF A SIMULATED BODY FORM FOR TESTING THE QUALITIES AND DURABILITIES OF THE "FIRM" MATTRESS.


THE DEVELOPMENT OF A REPORTING SYSTEM FOR REHABILITATION CENTERS.


PROGRESSIVE NEUROGENIC MUSCULAR ATROPHY SIMULATING MUSCULAR DYSTROPHY: REPORT OF THREE CASES.


MANAGEMENT OF DISORDERS OF THE TEMPOROMANDIBULAR JOINT.


SPEECH REHABILITATION OF THE LARYNGECTOMIZED PERSON.


ASSISTED WALKING BRACE FOR A CEREBRAL PALSIED CHILD.


THROMBOPHLEBITIS OF CEPHALIC VEIN AND PULMONARY EMBOLISM DUE TO BROMSULPHTHALEIN: REPORT OF A CASE.


THE RELATIONSHIP BETWEEN LUNG CANCER AND CHRONIC BRONCHITIS.


A MODIFIED THEORY OF RETROGRADE LYMPHATIC METASTASIS IN LUNG CANCER.


ATRESIA OF AN APICAL BRONCHUS OF THE LEFT UPPER LOBE--REPORT OF THREE CASES.


THE USE OF PREDNISOLONE IN CHRONIC BRONCHITIS.


ISOPRENALINE IN THE TREATMENT OF CHRONIC BRONCHITIS; A CONTROLLED TRIAL OF DIFFERENT METHODS OF ADMINISTRATION.


SPONTANEOUS REGRESSION OF PULMONARY METASTASES SECONDARY TO CARCINOMA OF KIDNEY.


A CONTROLLED TRIAL OF A NEW ANTIHISTAMINIC (MEBROPHENHYDRAMINE, "MEBRYL") IN THE TREATMENT OF ASTHMA.


JAUNDICE DUE TO ETHIONAMIDE.

JAUNDICE DUE TO ETHIONAMIDE.


SURGERY OF THE HAND IN GREAT BRITAIN.

SURGERY OF THE HAND IN GREAT BRITAIN.


THE CANDELABRA ARTERIES AND THE CIRCULATION OF THE CEREBRAL CORTEX.


STRING PHLEBITIS.

STRING PHLEBITIS.


MALIGNANT MIXED TUMOURS OF SKIN.

MALIGNANT MIXED TUMOURS OF SKIN.


MASSIVE HAEMOSIDERIN DEPOSITS IN HUMAN BREAST CANCER.


THE RECTAL APPROACH TO NEUROPATHOLOGY.

THE RECTAL APPROACH TO NEUROPATHOLOGY.


MASSIVE RESECTION OF THE SMALL INTESTINE IN INFANCY.


DEHISCENCE OF THE LATERAL SPACE FOLLOWING ITS CLOSURE IN COLOSTOMY AND ILEOSTOMY.


ANTERIOR SACRAL MENINGOCELE CAUSING URINARY RETENTION.


REVERSAL OF THE DUODENAL LOOP AFTER GASTRODUODENOSTOMY.


POSTMASTECTOMY LYMPHOSTATIC ENDOTHELIOMA OF STEWART AND TREVES IN A MALE.


THE PREVENTION OF WOUND OEDEMA: THE VALUE OF CHYMOTRYPSIN IN SURGERY--CLINICAL AND EXPERIMENTAL INVESTIGATIONS.


THE EARLIER PHASES OF DEFINITIVE HEALING IN AN EXPERIMENTAL SKIN WOUND.


ACUTE LEUKAEMIA PRESENTING AS A LUMP IN THE BREAST.


ACUTE OBSTRUCTION OF THE LARGE BOWEL DUE TO ENDOMETRIOSIS.


BREAST HAEMORRHAGE AND GANGRENE DURING ANTICOAGULANT THERAPY.


CHOLECYSTO-DUODENOCOLIC FISTULAE DUE TO GALL-STONES.


PRESENT STATE OF MEDICINE. 1. DIAGNOSIS.


PHYSIQUE AND SMOKING.

PHYSIQUE AND SMOKING.


QUATERNARY NITROGEN BASES IN HUMAN THYMUS GLANDS.


ROLE OF THE THYMUS IN IMMUNITY.

ROLE OF THE THYMUS IN IMMUNITY.


MALIGNANT MYELOSCLEROSIS.

MALIGNANT MYELOSCLEROSIS.


INCIDENCE OF RENAL LESIONS IN  POLYCYTHAEMIA: A SURVEY OF 91 PATIENTS.


MALARIAL ANTIBODY TITRES OF WEST AFRICANS IN BRITAIN.


SEROLOGICAL PREGNANCY TEST USING LATEX PARTICLES: AN ASSESSMENT OF ITS RELIABILITY AND CONVENIENCE.


ANKYLOSING SPONDYLITIS AND CHRONIC INFLAMMATORY DISEASES OF THE INTESTINES.


SMOKING DETERRENT STUDY: A REPORT FROM THE RESEARCH COMMITTEE OF THE BRITISH TUBERCULOSIS ASSOCIATION.


ACUTE PNEUMOCHOLECYSTITIS.

ACUTE PNEUMOCHOLECYSTITIS.


ORAL CONTRACEPTIVES.

ORAL CONTRACEPTIVES.


PHENYLKETONURIA.

PHENYLKETONURIA.


FRAMYCETIN AND THE STAPHYLOCOCCUS.

FRAMYCETIN AND THE STAPHYLOCOCCUS.


FUTURE OF GENERAL PRACTICE.

FUTURE OF GENERAL PRACTICE.


PULMONARY OEDEMA.

PULMONARY OEDEMA.


ABORTION AND PSYCHIATRIST.

ABORTION AND PSYCHIATRIST.


PSYCHIATRY AND APPENDICITIS.

PSYCHIATRY AND APPENDICITIS.


PERSISTENCE OF BARBITURATES.

PERSISTENCE OF BARBITURATES.


BINDING OF HORMONES BY PLASMA PROTEINS.

BINDING OF HORMONES BY PLASMA PROTEINS.


CONSUMER OPINION.

CONSUMER OPINION.


TONSILS AND ADNOIDS.

TONSILS AND ADNOIDS.


RABIES.

RABIES.


IMMUNOLOGICAL STUDIES IN THE POST-CARDIOTOMY SYNDROME.


THE MAIN CAUSE OF INCREASED DEATH RATE FROM DISEASE OF THE HEART: 1920 TO 1959.


SERUM CHOLESTEROL LEVELS AFTER MYOCARDIAL INFARCTION.


CASE-FINDING BY SERIAL TUBERCULIN-TESTING OF SCHOOLCHILDREN.


DECLINING TUBERCULIN SENSITIVITY WITH ADVANCING AGE.


TYPE-SPECIFIC IMMUNITY AGAINST WHOOPING-COUGH.


IDIOPATHIC RHABDOMYOLYSIS (MYOGLOBINURIA) AS AN ACUTE RESPIRATORY PROBLEM.


PYRIMETHAMINE AND SULPHADIAZINE IN TREATMENT OF MALARIA.


OBSTRUCTED LABOUR DUE TO CARCINOMA OF CERVIX.


REMPLOY CHAIRBATH.

REMPLOY CHAIRBATH.


RADIUM OVOID INTRODUCER.

RADIUM OVOID INTRODUCER.


NEED FOR INFECTIOUS DISEASES BEDS IN A LONDON AREA.


POLIOMYELITIS AND ALLIED DISEASES.

POLIOMYELITIS AND ALLIED DISEASES.


MIGRATION OF BRITISH DOCTORS TO AUSTRALIA.


THORACO-LUMBAR SYMPATHECTOMY AND MALIGNANT HYPERTENSION: REVIEW OF TWENTY CASES.


PH-1 CHROMOSOME IN THE DIAGNOSIS OF CHRONIC MYELOID LEUKEMIA: REPORT OF A CASE WITH FEATURES SIMULATING MYELOFIBROSIS.


FARABEE'S BRACHYDACTYLOUS KINDRED REVISITED.


PERSPECTIVES IN VENEREOLOGY--1962.

PERSPECTIVES IN VENEREOLOGY--1962.


SALMONELLA SPECIES PREVALENT IN INDIA.

SALMONELLA SPECIES PREVALENT IN INDIA.


THE USE OF IMMUNOFLUORESCENCE IN THE RAPID PRESUMPTIVE DIAGNOSIS OF VARIOLA.


THE PRESENT POSITION IN BRUCELLA PHAGE RESEARCH. A REVIEW OF THE LITERATURE. It is only comparatively recently that efforts to isolate and purify stable Brucella phages have met with success. This success has important implications for the epidemiology and possibly the control of brucellosis, and the author has therefore thought it opportune to summarize and review the present state of research on Brucella phages.After giving an outline of the history of Brucella phage isolation, she goes into the methodology of phage isolation from numerous sources, of phage reinforcement, and of determination of the lytic activity of phage. This is followed by a discussion of the biological properties, morphology and typing of Brucella phage, and of lysogeny in Brucella. Finally, she reviews the promising research that is being done on Brucella typing with specific phage and on the use of antiphage serum in diagnosis, and discusses the possible use of phage in the treatment and prevention of brucellosis.


YELLOW FEVER VACCINATION IN MALAYA BY SUBCUTANEOUS INJECTION AND MULTIPLE PUNCTURE. HAEMAGGLUTININ-INHIBITING ANTIBODY RESPONSES IN PERSONS WITH AND WITHOUT PRE-EXISTING ANTIBODY. In view of the risk of introduction of yellow fever into South-East Asia, comparative studies have been made of yellow fever vaccination in Malayan volunteers with a high prevalence of antibody to related viruses and in volunteers without related antibody. In a previous paper the neutralizing antibody responses of these volunteers were reported. The present paper describes the haemagglutinin-inhibiting (HI) antibody responses of the same groups of volunteers and discusses the relationship of these responses to the neutralizing antibody responses.The HI responses to yellow fever following vaccination closely paralleled the neutralizing antibody responses whether vaccination was subcutaneous or by multiple puncture. Volunteers with a high level of YF HI antibody due to infection with other group B viruses were found to be less likely to show a significant YF HI response than those without antibody. 90% of HI responses could be detected by the 21st day after vaccination.As with neutralizing antibody responses, volunteers given vaccine doses of 50-500 mouse intracerebral LD(50) subcutaneously gave greater responses than those given higher doses.


TICK-BORNE VIRUSES. A REVIEW OF AN ARTHROPOD-BORNE VIRUS PROBLEM OF GROWING IMPORTANCE IN THE TROPICS. More than 150 arthropod-borne viruses are now recognized, and over 50 of these are known to produce human infections and disease. Among these viruses are those of the tick-borne Russian spring-summer complex, which is etiologically involved in a wide variety of human diseases of varying severity. The eight antigenically different members of this complex so far known are Russian spring-summer encephalitis, louping-ill, Central European encephalitis, Omsk haemorrhagic fever, Kyasanur Forest disease, Langat, Negishi and Powassan viruses.In his review of the problems posed by these viruses and of research on them, the author points out that, while this complex is distributed around the globe in the temperate zone of the northern hemisphere, the only serious tick-borne virus disease known in the tropics is Kyasanur Forest disease. It is probable, however, that there are other, unrecognized tick-borne viruses in the tropical areas of Asia, Africa and America of importance to human health, and that these will be brought to light as virological studies of diseases of now obscure etiology are pursued.


DESTRUCTION OF THE LARVAE OF ANOPHELES GAMBIAE GILES BY A COELOMOMYCES FUNGUS. A mortality of 95%, or higher, has been found to occur among larvae of Anopheles gambiae in several breeding-areas at Livingstone, Northern Rhodesia, resulting from parasitization by an aquatic fungus of the genus Ceolomomyces. During six weeks of almost continuous rainfall the pathogen maintained this high percentage kill in pools in nine different areas. After the rains had practically ceased some of the pools were kept filled with river water and the activity of this parasite continued. Coelomomyces was successfully introduced into an uninfected breeding-pool. Larvae of culicine mosquitos occurring in infected pools seldom develop the A. gambiae disease and larvae of Anopheles squamosus Theo. showed only a low percentage of parasitization. The author stresses that laboratory research should be aimed at culturing the pathogen in an artificial medium. Exhaustive field trials of a practical nature, for spreading infections among A. gambiae populations, are required before there can be any question of employing this organism as a biological control agent.


ON THE ORIGIN OF THE HUMAN TREPONEMATOSES (PINTA, YAWS, ENDEMIC SYPHILIS AND VENEREAL SYPHILIS). A close relationship between the four human treponematoses is suggested by their clinical and epidemiological characteristics and by such limited knowledge of the treponemes as there is at present. No treponeme of this group (except for that of the rabbit) is known other than in man, but the human treponemes probably arose long ago from an animal infection. The long period of infectiousness of pinta suggests that it may have been the earliest human treponematosis. It may have been spread throughout the world by about 15 000 B.C., being subsequently isolated in the Americas when the Bering Strait was flooded. About 10 000 B.C. in the Afro-Asian land mass environmental conditions might have favoured treponeme mutants leading to yaws; from these, about 7000 B.C., endemic syphilis perhaps developed, to give rise to venereal syphilis about 3000 B.C. in south-west Asia as big cities developed there. Towards the end of the fifteenth century A.D. a further mutation may have resulted in a more severe venereal syphilis in Europe which, with European exploration and geographical expansion, was subsequently carried throughout the then treponemally uncommitted world. These suggestions find some tentative support in climatic changes which might have influenced the selection of those treponemes which still survive in humid or arid climates. Venereal transmission would presumably remove the treponeme from the direct influence of climate. The author makes a plea for further investigation of many aspects of this subject while this is still possible.


THE INTERNATIONAL STANDARD FOR NYSTATIN. At the request of a WHO Expert Committee on Biological Standardization, a batch of nystatin, comparable in purity to material used therapeutically, was submitted to an international collaborative study in nine laboratories in six countries. In this study the material was assayed by the plate diffusion method (and in one laboratory also by a turbidimetric method) against the United States Pharmacopeia Reference Preparation of Nystatin. On the basis of the results obtained the material has been established as the International Standard for Nystatin, and the International Unit of Nystatin is defined as the activity in 0.000333 mg of the International Standard.


REHABILITATION OF THE LARYNGECTOMEE.

REHABILITATION OF THE LARYNGECTOMEE.


PEUTZ-JEGHERS SYNDROME: A CLINICAL-PATHOLOGICAL STUDY OF A LARGE FAMILY WITH A 10-YEAR FOLLOW-UP.


TROPHOCARCINOMA (EMBRYONAL CARCINOMA) OF THE TESTIS. FACTORS INFLUENCING RADIATION AND SURGICAL TREATMENT.


CHROMOSOME CONSTITUTION OF DIPLOID AND PSEUDODIPLOID CELLS IN EFFUSIONS OF CANCER PATIENTS.


RADIOACTIVE IODINE IN THE DIAGNOSIS AND TREATMENT OF THYROID CANCER.


PRIMARY SOLID TUMORS OF THE MESENTERY.

PRIMARY SOLID TUMORS OF THE MESENTERY.


PULMONARY MALIGNANT LYMPHOMAS AND PSEUDOLYMPHOMAS: CLASSIFICATION, THERAPY, AND PROGNOSIS.


DEVELOPMENT OF THE DORSAL INTEROSSEI IN THE HUMAN HAND.


OBSERVATIONS ON THE PULMONARY VASCULAR RESISTANCE FOLLOWING SURGICAL CLOSURE OF HIGH-RESISTANCE VENTRICULAR SEPTAL DEFECTS.


PULMONARY EMBOLECTOMY USING TEMPORARY CARDIOPULMONARY BYPASS FOR ACUTE MASSIVE PULMONARY EMBOLISM IN A PATIENT WITH PREVIOUS PULMONARY  INFARCTION.


STUDENT RESEARCH AND THE CLINICAL LABORATORY.


MECHANISMS OF DYSPNEA IN OBESITY.

MECHANISMS OF DYSPNEA IN OBESITY.


CORONARY ENDARTERECTOMY FOR ANGINA PECTORIS.


VENTRICULAR DEFIBRILLATION IN THE DOG BY CONDENSER DISCHARGE APPLIED DIRECTLY TO THE HEART.


CYCLOPHOSPHAMIDE THERAPY IN LYMPHOMA OF THE DOG.


ON THE OCCURRENCE OF INTRANUCLEAR PAS-POSITIVE MATERIAL IN LIVER CELLS OF CATTLE.


RADIAL PARALYSIS IN THE HORSE.

RADIAL PARALYSIS IN THE HORSE.


AN INTERESTING TYPE OF ABNORMAL BULL SPERM.


A METHOD FOR THE MORPHOLOGIC COMPARISON OF CULTURED CELLS BY ELECTRON AND PHASE CONTRAST MICROSCOPY.


PHYSIOLOGICAL MECHANISMS OF IMPLANTATION.


CONDITIONS INFLUENCING VIRUS-NEUTRALIZATION TESTS FOR INFECTIOUS CANINE HEPATITIS ANTIBODY.


SALMONELLA TYPES FOUND IN THE MESENTERIC LYMPH NODES OF VARIOUS DOMESTIC ANIMALS.


CLINICAL MANIFESTATIONS OF IBR IN NEW YORK STATE. A CASE REPORT.


SEMINOMA IN THE STALLION. A CLINICAL, CYTOLOGICAL, AND PATHOLOGICOANATOMICAL INVESTIGATION.


FEED AND OVARIAN ACTIVITY OF TROTTING MARES IN TRAINING.


EQUINE INCOORDINATION. I. GROSS MORPHOLOGY.


STUDIES ON RIFT VALLEY FEVER IN LABORATORY ANIMALS.


VIABLE MICROCOCCI AND STREPTOCOCCI OTHER THAN STREPTOCOCCUS AGALACTIAE THAT REMAIN ON THE SURFACE OF COWS' TEATS AFTER THE USE OF CERTAIN DISINFECTANTS AS DIPPING AGENTS.


TETANUS IN CATTLE.

TETANUS IN CATTLE.


WILLIAM ARTHUR HAGAN, OCTOBER 14, 1893--FEBRUARY 1, 1963.


IMMUNOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDIES ON THE DEVELOPMENT OF THE CELLULAR SLIME MOLD DICTYOSTELIUM MUCOROIDES.


CHEMICAL DISSOLUTION AND IN VITRO RECONSTRUCTION OF SPONGE CELL ADHESIONS. I. ISOLATION AND FUNCTIONAL DEMONSTRATION OF THE COMPONENTS INVOLVED.


HISTOCHEMICAL STUDIES ON THE REGENERATING URODELE LIMB. I. OXIDATIVE AND GLYCOGENIC ENZYMES.


CYTOCHROME CHANGES DURING HONEY BEE FLIGHT MUSCLE DEVELOPMENT.


CHANGES IN MELANOGENESIS DURING THE DEDIFFERENTIATION OF CHICK RETINAL PIGMENT CELLS IN CELL CULTURE.


ON THE VALUE OF PAS REACTION FOR DETERMINING THE TYPE OF ACUTE LEUCOSIS.


POSTNATAL USE OF PENICILLIN AND ITS EFFECT ON COLIENTEROCOLITIS IN GUINEA-PIGS.


OBSERVATIONS ON CHROMOSOME DUPLICATION IN CULTURED  HUMAN LEUCOCYTES.


SOME EFFECTS OF ANAEROBIOSIS ON THE GROWTH AND METABOLISM OF HELA CELLS.


OSSIFICATION IN TISSUE CULTURE.  II. CHEMICAL DEVELOPMENT OF THE FEMUR OF CHICK EMBRYO IN VARIOUS LIQUID MEDIA.


THE EFFECT OF INJURY UPON THE UPTAKE OF 3-H-THYMIDINE BY  GUINEA PIG EPIDERMIS.


IMBALANCE OF NON-ESSENTIAL AMINO  ACIDS AND CELL GROWTH.


REDUCTION OF NUCLEAR DAMAGE IN X-IRRADIATED RAT THYMOCYTES BY  ELEVATED SALT CONCENTRATIONS.


A STUDY OF THE NUCLEUS AND CELL MEMBRANES OF OOCYTES WITH AN  INTRA-CELLULAR ELECTRODE.


A QUANTITATIVE CYTOCHEMICAL AND PHYSIOLOGICAL  STUDY OF THE RAT ADRENAL CORTEX IN HYPERTROPHY AFTER UNILATERAL ADRENALECTOMY.


RADIOMIMETIC EFFECTS OF A NITROGEN MUSTARD  ON SURVIVAL , GROWTH, PROTEIN AND NUCLEIC ACID SYNTHESIS OF MAMMALIAN CELLS IN VITRO.


INCORPORATION OF 3-H-THYMIDINE IN THE EGGS OF ARBACIA PUNCTULATA. A  PRESSURE STUDY.


RIBONUCLEIC ACIDS IN THE EARLY EMBRYONIC DEVELOPMENT OF  THE SEA URCHIN. I. QUANTITATIVE VARIATIONS AND 32-P ORTHOPHOSPHATE INCORPORATION  STUDIES OF THE RNA OF SUBCELLULAR FRACTIONS.


STUDIES ON CELLULAR ADHESION IN TISSUE-CULTURE. VI. INITIAL CELL CONTACTS  AND MORPHOGENETIC MOVEMENTS.


THE FINE STRUCTURE OF ISOLATED HELA CELL NUCLEI.


PLASMA CREATINE KINASE ACTIVITY IN MICE WITH HEREDITARY MUSCULAR DYSTROPHY.


A QUANTITATIVE ASSESSMENT OF MOUSE  THYMUS DIFFERENTIATION.


AUTORADIOGRAPHIC METHODS IN  ENZYME CYTOCHEMISTRY. I. LOCALISATION OF ACETYLCHOLINESTERASE ACTIVITY USING A 3-H LABELED IRREVERSIBLE INHIBITOR.


THE METABOLISM OF GROWING MUSCLE. II. OXIDATION OF VARIOUS SUBSTRATES  BY MITOCHONDRIA AND HOMOGENATES OF DEVELOPING RAT MUSCLE.


THE DIAGNOSIS OF RENAL HYPERTENSION.

THE DIAGNOSIS OF RENAL HYPERTENSION.


WHEN IS THE THYROID NODULE MALIGNANT?

WHEN IS THE THYROID NODULE MALIGNANT?


THE VALUE OF CERVICAL CONE BIOPSIES.

THE VALUE OF CERVICAL CONE BIOPSIES.


MANUAL SKILL IN PARKINSON'S DISEASE.

MANUAL SKILL IN PARKINSON'S DISEASE.


THE DIAGNOSIS AND TREATMENT OF PERFORATED PEPTIC ULCER.


MODERN SOCIETY'S ATTITUDE TOWARD AGING.

MODERN SOCIETY'S ATTITUDE TOWARD AGING.


TREATMENT OF CHRONIC INTRACTABLE EDEMA BY EXTRACORPOREAL ULTRAFILTRATION.


PAROTID INFECTION CAUSED BY DRYNESS OF MOUTH. REPORT OF 3 CASES AFTER USE OF TRANQUILIZERS.


MANAGEMENT OF ESOPHAGEAL HIATUS SLIDING HERNIA.


TREATMENT OF SKIN CANCER.

TREATMENT OF SKIN CANCER.


THE POLYURIC SYNDROMES.

THE POLYURIC SYNDROMES.


THE MANAGEMENT OF SEXUAL IMPOTENCE.

THE MANAGEMENT OF SEXUAL IMPOTENCE.


BRONCHOGRAPHY SIMPLIFIED.

BRONCHOGRAPHY SIMPLIFIED.


ANNUAL REPORT OF THE EXECUTIVE DIRECTOR.


VIRAL CENTRAL NERVOUS SYSTEM DISEASE.

VIRAL CENTRAL NERVOUS SYSTEM DISEASE.


BREAST FEEDING IN PERSPECTIVE.

BREAST FEEDING IN PERSPECTIVE.


ABDOMINAL TRAUMA.

ABDOMINAL TRAUMA.


VAGINITIS.

VAGINITIS.


PRESCRIPTION USE OF FLUORIDE TO CONTROL TOOTH DECAY.


PROFESSOR GEORGE PAYLING WRIGHT.

PROFESSOR GEORGE PAYLING WRIGHT.


MULTIPLE FACTORS IN THE PATHOGENESIS OF ATHEROSCLEROSIS.


THE BLOOD-BRAIN BARRIER: SOME RECENT DEVELOPMENTS.


SOME OBSERVATIONS ON THE CLINICAL PATHOLOGY OF ISCHAEMIC HEART DISEASE.


THE POSSIBLE PHYSIOLOGICAL SIGNIFICANCE OF SOME LIPID ANIONS.


ORGANO-PHOSPHORUS NEUROTOXICITY: A MODEL "DYING BACK" PROCESS  COMPARABLE TO CERTAIN HUMAN NEUROLOGICAL DISORDERS.


THE CHANGING FACE OF FORENSIC MEDICINE, 1930-1960.


SOME EXPERIMENTAL APPROACHES TO THE STUDY OF LEPROSY.


THE MECHANISMS AND SIGNIFICANCE OF IMMUNOLOGICAL ENHANCEMENT.


IMMUNOLOGICAL MODIFICATIONS OF GRAFT-VERSUS-HOST REACTION.


STUDIES ON THE IMMUNE RESPONSES OF CONTINUOUSLY IRRADIATED MICE.


PROPERTIES OF HISTOCOMPATIBILITY-2 ANTIGENS FROM  DIFFERENT TISSUES.


AUTO-IMMUNE DISEASE.

AUTO-IMMUNE DISEASE.


HYPERSENSITIVITY REACTIONS IN MAN TO FUNGI, VEGETABLE DUSTS AND TUBERCULIN.


IMMUNE RESPONSES TO EXPERIMENTAL TUMOURS.


CARCINOGENESIS, A BIOLOGICAL PROCESS.

CARCINOGENESIS, A BIOLOGICAL PROCESS.


THE ROLE OF VIRUSES IN CANCER.

THE ROLE OF VIRUSES IN CANCER.


THE SUSCEPTIBILITY OF THE SKIN AND EPIDERMOID MUCOUS MEMBRANES TO VIRUS  INFECTION IN MAN AND OTHER ANIMALS.


THE PATHOGENESIS OF FOETAL HYDROPS.

THE PATHOGENESIS OF FOETAL HYDROPS.


MOST FREQUENTLY REORDERED HOMEOPATHIC REMEDIES--AND WHY.


THE DEVELOPMENT OF THE MED. TECH.  CURRICULUM.


PERSONNEL ADMINISTRATION FROM POSITION  ANALYSIS TO WAGE ADMINISTRATION. 1. OBJECTIVES.


PERSONNEL ADMINISTRATION. 3. EDUCATION. THE  ROLE OF THE NURSE IN THE CHANGING HOSPITAL PATTERNS.


PERSONNEL ADMINISTRATION. 4. PROGRESS. THE PROGRAM'S EFFECT ON THE PATIENT,  THE EMPLOYE, THE PHYSICIAN, THE HOSPITAL AND THE COMMUNITY.


PERSONNEL MANAGEMENT--PLANNED AND CONTROLLED.


PERSONNEL MANAGEMENT.

PERSONNEL MANAGEMENT.


NONMEDICAL EMPLOYE SELECTION TECHNIQUES.


EMPLOYE RECOGNITION PROGRAM.

EMPLOYE RECOGNITION PROGRAM.


MULTIPLE SUPERFICIAL BASAL CELL EPITHELIOMA.


ISOLATION OF NEW FRACTIONS FROM TRAGACANTH.


EFFECT OF X-IRRADIATION ON DNA-LABELLING IN CELLS EXPOSED DURING SYNTHESIS.


VARIATION IN RADIOSENSITIVITY DURING THE CELL-CYCLE OF OEDOGONIUM CARDIACUM.


THE EFFECT OF DIETARY PHOSPHORUS ON THE METABOLISM OF CALCIUM AND STRONTIUM IN THE RAT.


RADIOSENSITIVITY OF NUCLEAR ATP-SYNTHESIS.


PARALYTIC LAGOPHTHALMOS AND ITS TREATMENT.


ON VISUAL CHARTS.

ON VISUAL CHARTS.


PRIMARY TUMOURS OF THE ORBIT.

PRIMARY TUMOURS OF THE ORBIT.


CRANIOSTENOSIS.

CRANIOSTENOSIS.


THE THREE-MIRROR CONTACT LENS.

THE THREE-MIRROR CONTACT LENS.


ROENTGENOGRAPHIC EVALUATION OF GROWTH AND DEVELOPMENT: A REVIEW.


OPERATIVE PROCEDURES FOR CHILDREN.

OPERATIVE PROCEDURES FOR CHILDREN.


ORAL HYGIENE: ITS ASSOCIATION WITH PERIODONTAL DISEASE AND DENTAL CARIES IN CHILDREN.


IMPLANT DENTURES: FOLLOW-UP AFTER SEVEN TO TEN YEARS.


SURGICAL CORRECTION OF SUBLINGUAL REGION.


STRENGTH, HARDNESS AND ABRASION CHARCTERISTICS OF DENTAL CEMENTS.


PRINCIPLES OF ADHESIVE RETENTION AND ADHESIVE RESTORATIVE MATERIALS.


PHOSPHORESCENCE OF TEETH COOLED IN LIQUID NITROGEN.


A POSSIBLE CASE IN A HUMAN AND AN INVESTIGATION IN DOGS OF DEATH FROM AIR EMBOLISM DURING ROOT CANAL THERAPY.


COOPERATION BETWEEN GENERAL PRACTITIONER AND ORTHODONTIST.


SURVEY OF DENTISTS OVER 60. I. INTRODUCTION; AGE AND RETIREMENT. BUREAU OF ECONOMIC RESEARCH AND STATISTICS.


PROFILE OF USAF DENTAL SERVICE IN THE EMERGENCY MEDICAL CARE PROGRAM.


AUTOMATION AND MANPOWER.

AUTOMATION AND MANPOWER.


DIGITAL COMPUTER SIMULATIONS OF A CAFETERIA  SERVICE LINE.


FOOD TEMPERATURE PREFERENCES OF SURGICAL PATIENTS.


NUTRITION IN THE TREATMENT OF PHENYLKETONURIA.


NUTRITION IN THE TREATMENT OF GALACTOSEMIA.


EATING BEHAVIOR AND DIETARY INTAKE OF  GIRLS 12 TO 14 YEARS OLD.


TEEN-AGERS TELL US ABOUT THEIR NUTRITION.


EFFECTS OF COPPER ON BACILLUS SUBTILIS.

EFFECTS OF COPPER ON BACILLUS SUBTILIS. Weed, Lawrence L. (Western Reserve University, Cleveland, Ohio). Effects of copper on Bacillus subtilis. J. Bacteriol. 85:1003-1010. 1963.-Variants have been isolated from liquid cultures of Bacillus subtilis 168 after exposure to copper. The variations manifested are in terms of loss of capacity to be transformed from tryptophan auxotrophy to prototrophy as shown by variant NTCu, and in terms of colony size and altered base composition of the deoxyribonucleic acid as shown by variant SC-22. In addition to the data on altered morphology and chemical composition of the variants, detailed studies on the reversion of one of the variants to B. subtilis are presented.


CORRELATION OF SPECIATION WITH LYTIC RESPONSES OF THE  ACHROMOBACTER. Surdy, Theodore E. (Purdue University, Lafayette, Ind.) and S. E. Hartsell. Correlation of speciation with lytic responses of the Achromobacter. J. Bacteriol. 85:1011-1016. 1963.-Lysozymic lysis of six species of Achromobacter was investigated. Three of the six species were lysed with 33, 50, or 100 mug/ml of lysozyme; if higher concentrations of lysozyme were used, precipitation of cells occurred. "Insensitive" cells could be sensitized by the addition of potassium hydroxide, n-butanol, steapsin, or urea, as demonstrated by the subsequent addition of lysozyme. Not all species were sensitive to these agents in the same degree; hence, a spectrum was obtained after the use of the pretreating agents and lysozyme. Optimal clearing of suspensions was observed when cells were suspended in pH 6.6 physiological saline or 0.15 m phosphate buffer and incubated at 45 C. Heat treatment (75 C for 10 min) or freezing (-32 C) and thawing (room temp, 25 C) for one cycle did not increase the sensitivity of the cells to lysozyme. Injury to the cells was evident by the increased amount of lysis noted after pretreatment with potassium hydroxide. When cells were frozen and thawed for three cycles, four of the six species were sensitive to the action of lysozyme. Isolated cell walls elicited a similar lytic pattern to that of whole cells. Individuality of the lytic response of the species (from most sensitive to least sensitive-A. aquamarinus, A. butyri, A. viscosus, A. parvulus, A. guttatus, A. hartlebii) produced a separation scheme. Exhaustive tests proved it to be stable and reliable for these species. The organisms were identified, with the use of the separation scheme, by a person initially unfamiliar with the scheme or the culture.


INTERRELATIONSHIP BETWEEN TEMPERATURE AND  SODIUM CHLORIDE ON GROWTH OF LACTIC ACID BACTERIA ISOLATED FROM MEAT-CURING BRINES. Goldman, Manuel (American Meat Institute Foundation, Chicago, Ill.), R. H. Deibel, and C. F. Niven, Jr. Interrelationship between temperature and sodium chloride on growth of lactic acid bacteria isolated from meat-curing brines. J. Bacteriol. 85:1017-1021. 1963.-An elevation of the temperature limit for growth of some Pediococcus homari (Gaffkya homari) and motile Lactobacillus strains could be effected by the addition of sodium chloride to the growth medium. At the optimal temperature for growth, sodium chloride was stimulatory, and as the temperature of incubation was increased a mandatory requirement for sodium chloride was manifested. At the optimal temperature for growth (30 C), the highest sodium chloride concentrations were tolerated; as the temperature was increased, this tolerance decreased, although the optimal sodium chloride concentration increased. No other substances were found that would replace the sodium chloride requirement at higher temperatures of incubation.


IN VITRO BIOLOGICAL ACTIVITY OF CEPHALOTHIN. Chang, Te-Wen (Tufts University School of Medicine, Boston, Mass.) and Louis Weinstein. In vitro biological activity of cephalothin. J. Bacteriol. 85:1022-1027. 1963.-Cephalothin is a "broad-spectrum" antibiotic active, in low concentrations, against Diplococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus. Shigella, Salmonella, and Proteus mirabilis were the most sensitive of the gram-negative organisms. Escherichia coli and Aerobacter aerogenes were suppressed to a lesser degree, whereas Pseudomonas aeruginosa and Herellea were highly resistant. Penicillin-sensitive and -resistant strains of S. aureus were equally susceptible to cephalothin. Exposure to increasing concentrations of the drug very frequently led to the development of resistance in gram-negative organisms; this was observed less often with S. aureus. Cephalothin stimulated the production of penicillinase by staphylococci, which remained sensitive to the cephalosporanic acid derivatives despite repeated subculture in increasing concentrations of the agent. Cephalothin was not inhibited by penicillinase. This antibiotic was more toxic to cultures of human amnion and mouse embryo cells than benzyl penicillin G but was less injurious than oxytetracycline, chlortetracycline, and demethylchlortetracycline; tetracylcine produced about the same degree of cellular damage as cephalothin.


ACTION OF FORMALDEHYDE ON MICROORGANISMS. I. CORRELATION OF ACTIVITY WITH  FORMALDEHYDE METABOLISM. Neely, W. Brock (The Dow Chemical Co., Midland, Mich.). Action of formaldehyde on microorganisms. I. Correlation of activity with formaldehyde metabolism. J. Bacteriol. 85:1028-1031. 1963.-The action of formaldehyde in concentrations sublethal for the culture appeared to be at least twofold. The first phase caused a drop in viability, followed by a second phase where bacteriostatic conditions existed. During both these intervals, formaldehyde was being metabolized. As soon as the organism had lowered the formaldehyde concentration to a critical level, the normal growth cycle was resumed, with a resultant increase in cell population.


DUAL NATURE  OF RESISTANCE MECHANISMS AS REVEALED BY STUDIES OF ANTHRAX SEPTICEMIA. Klein, Frederick (Fort Detrick, Frederick, Md.), Bertram W. Haines, Bill G. Mahlandt, Ira A. DeArmon, Jr., and Ralph E. Lincoln. Dual nature of resistance mechanisms as revealed by studies of anthrax septicemia. J. Bacteriol. 85:1032-1038. 1963.-From studies of septicemic anthrax, resistance was described in relation to toxin and to growth of bacilli. This description was based on the observations that the terminal concentrations of bacilli in the blood were influenced primarily by the susceptibility of the host to toxin, whereas the death-response time of the host was dependent on both resistance to bacilli and toxin susceptibility. Resistance to the establishment and growth of infecting organisms and susceptibility to the toxin produced by growth of the bacilli are separate aspects of pathogenesis. A complete description of pathogenesis must accordingly treat of both these phenomena as individual entities.


CLASSIFICATION OF MICROORGANISMS  BY ANALYSIS OF CHEMICAL COMPOSITION. I. FEASIBILITY OF UTILIZING GAS CHROMATOGRAPHY. Abel, K. (Melpar, Inc., Falls Church, Va.), H. deSchmertzing, and J. I. Peterson. Classification of microorganisms by analysis of chemical composition. I. Feasibility of utilizing gas chromatography. J. Bacteriol. 85:1039-1044. 1963.-The feasibility of utilizing gas chromatography as a sensitive and rapid method for the analysis of lipids as a natural basis for the classification of microorganisms by chemical composition was investigated. The lipids were extracted and transesterified to component carboxylic acid methyl esters in a single step, after which the methyl esters were resolved by gas chromatography to provide distinctive chromatographic elution patterns. Similarities in the lipid carboxylic acid distribution were noted among selected species of the family Enterobacteriaceae, and significant differences were noted among selected families of the class Schizomycetes.


ISOLATION OF ENTEROVIRUSES FROM THE "NORMAL" BABOON (PAPIO DOGUERA). Fuentes-Marins, R. (Southwest Foundation for Research and Education, San Antonio, Texas), A. R. Rodriguez, S. S. Kalter, A. Hellman, and R. A. Crandell. Isolation of enteroviruses from the "normal" baboon (Papio doguera). J. Bacteriol. 85: 1045-1050. 1963.-In a study designed to determine whether the baboon (Papio doguera) would be suitable for use as a model of human virus infections, the normal enterovirus flora was determined. Five agents were isolated from 101 stool samples: four from the African group and one from the African-African group. None of the stool samples from the Domestic group of animals was found to contain any agents. On the basis of their biological characterizations (animal source, cytopathic effect, plaque formation, and antigenic relationships), the isolates were separated into two groups. Accordingly, prototype strains AA153 and A13 were designated for the African-African and African groups, respectively. These viruses have not been found to be related to any known human viruses. Their relationship to organisms isolated from other animals, especially primates, awaits study. The failure to detect latent viruses in preparations of baboon kidney cell cultures suggests a relatively "clean" animal which may be used with safety in preparation of vaccine for human administration.


IDENTIFICATION OF GROWTH STIMULANTS FOR STREPTOCOCCUS  LACTIS. Koburger, J. A. (North Carolina State College, Raleigh), M. L. Speck, and L. W. Aurand. Identification of growth stimulants for Streptococcus lactis. J. Bacteriol. 85:1051-1055. 1963-The growth of Streptococcus lactis in milk was accelerated by pancreas extract, and three distinct components that were detected by bioautography were isolated and identified. These were purified by precipitation with silver ions, and their silver salts were regenerated in acidic solution. After adsorption and elution from characoal, contaminating alpha-amino compounds were destroyed by treatment with ninhydrin. Final purification was by chromatography. Identification of the purified fractions was by paper chromatography, and by ultraviolet and infrared spectra. The active compounds were found to be inosine, hypoxanthine, and adenine.


FATTY ACID COMPOSITION OF LIPIDS FROM STREPTOCOCCUS  CREMORIS AND STREPTOCOCCUS LACTIS VAR. MALTIGENES. MacLeod, Patricia (University of Connecticut, Storrs) and Joseph P. Brown. Fatty acid composition of lipids from Streptococcus cremoris and Streptococcus lactis var. maltigenes. J. Bacteriol. 85:1056-1060. 1963.-A method for the extraction of lipids from bacterial cells, involving grinding in a ball mill, is described. Cells of Streptococcus lactis var. maltigenes and S. cremoris yielded 5.3 and 5.5%, respectively, of their dry cellular weights as lipid. The lipids of both organisms were separated into three fractions by thin-layer chromatography. Two of these fractions have been classified: one fraction containing phospho- and perhaps glycolipids and the other containing triglycerides. The unidentified fraction was probably either mono- or diglyceride in nature. The fatty acid composition of the total lipid as well as that of each of the separated lipid components from the two lactic strains were compared.


QUANTITATIVE APPROACH TO THE STUDY OF BACTERIAL SPECIES. Liston, J. (University of Washington, Seattle), W. Wiebe, and R. R. Colwell. Quantitative approach to the study of bacterial species. J. Bacteriol. 85:1061-1070. 1963.-The stability of strains of various species of gram-negative, rod-shaped bacteria was investigated by subculturing each strain through ten different media, testing the substrains so produced through a standard series of tests, and analyzing the resulting data by electronic computer. Strain stability was shown to be high [similarity coefficient (S) >/= 80%], and some evidence was obtained for species stability (S >/= 75%). The limits of variability for a species were studied by use of Pseudomonas aeruginosa; 33 P. aeruginosa strains (from the American Type Culture Collection) were tested and found to share a high level of similarity. An analysis was made of the distribution of positive characters among the strains, and the group was found to have a mean total of 35 characters (out of a possible 78 which were coded and included in the computer analyses) with a range of 33 to 39 positive characters in individual organisms. The frequency of occurrence of each positive character and the probability of mutual occurrence of pairs of positive characters were calculated. By use of the quantitative and qualitative data so obtained, a hypothetical Median Organism for the P. aeruginosa group was derived. The species may then be defined as consisting of all strains which show an S relationship of 75% or more with the Median Organism. The general applicability of this concept is discussed.


SIMILARITY IN BASE  COMPOSITIONS OF DEOXYRIBONUCLEATES FROM SEVERAL STRAINS OF BACILLUS CEREUS AND BACILLUS  ANTHRACIS. McDonald, William C. (U.S. Army Biological Laboratories, Frederick, Md.), Ira C. Felkner, Abraham Turetsky, and Thomas S. Matney. Similarity in base compositions of deoxyribonucleates from several strains of Bacillus cereus and Bacillus anthracis. J. Bacteriol. 85:1071-1073. 1963.-Studies were made on the base compositions of the deoxyribonucleates of a number of Bacillus species. Species homogeneity was quite evident from these studies since, with only one exception, several strains of the same species showed identical base compositions. It was found that the melting temperatures and corresponding percentages of guanine plus cytosine were quite similar in several strains of B. cereus and B. anthracis. These aspects are discussed as related to their possible genetic homology.


ENDOTOXIN-INDUCED TOLERANCE TO TOXIC MANIFESTATIONS OF  CANDIDA ALBICANS. Hasenclever, H. F. (National Institutes of Health, Bethesda, Md.) and William O. Mitchell. Endotoxin-induced tolerance to toxic manifestations of Candida albicans. J. Bacteriol. 85:1088-1093. 1963.-Mice exposed to 425 r total body irradiation failed to become tolerant to Candida albicans toxicity after injection with lipopolysaccharide. Mice injected with lipopolysaccharide and then X-rayed did not demonstrate the tolerant state. An injection of thorium dioxide in mice that had previously received tolerance-inducing amounts of lipopolysaccharide rendered them as susceptible to acute C. albicans toxicity as control mice. A bimodal manifestation of tolerance was noted. Groups of mice given single injections of lipopolysaccharide at 6 or 1 days before challenge demonstrated high levels of tolerance, whereas the tolerance in mice given a single dose at 3 days was negligible. The bimodal effect was not observed in tolerant mice challenged with lipopolysaccharide. Injections of viable or nonviable pathogenic fungi known to produce tolerance to the toxicity of C. albicans in recipient mice did not produce tolerance to lipopolysaccharide. Serum from mice injected with lipopolysaccharide showed in vitro inhibitory activity for C. albicans.


METHYL KETONE METABOLISM IN HYDROCARBON-UTILIZING MYCOBACTERIA. Lukins, H. B. (University of Texas, Austin) and J. W. Foster. Methyl ketone metabolism in hydrocarbon-utilizing mycobacteria. J. Bacteriol. 85: 1074-1087. 1963.-Species of Mycobacterium especially M. smegmatis 422, produced the homologous methyl ketones during the oxidation of propane, n-butane, n-pentane, or n-hexane. A carrier-trapping experiment demonstrated the formation of 2-undecanone, as well as 1,11-undecanedioic acid, during the oxidation of undecane-1-C(14). Aliphatic alkane-utilizing mycobacteria were able to grow at the expense of several aliphatic methyl ketones as sole sources of carbon. Other ketones which did not support growth were oxidized by resting bacterial suspensions. M. smegmatis 422 cells grown on propane or acetone were simultaneously adapted to oxidize both substrates, as well as n-propanol. n-Propanol cells were unadapted to propane or acetone. Acetone produced from propane in a medium enriched in D(2)O contained a negligible quantity of D, presumably eliminating propylene as an intermediate in the oxidation. Cells grown at the expense of alkanes or methyl ketones in the presence of O(2) (18) had a higher content of O(18) than did cells grown on terminally oxidized compounds, e.g., primary alcohols or fatty acids. An oxygenase reaction is postulated for the attack on methyl ketones. Acetol was isolated and characterized as an oxidation product of acetone by M. smegmatis 422. Acetol-grown cells had a higher O(18) content than did n-propanol cells, and its utilization appears to involve at least one oxygenase reaction. Acetol produced from acetone in the presence of O(2) (18) was not enriched in the isotope, indicating the occurrence of exchange reactions or of oxygenation reactions at a later stage in the assimilation of acetone and acetol.


CHARACTERISTICS OF CLOSTRIDIUM PERFRINGENS  STRAINS ASSOCIATED WITH FOOD AND FOOD-BORNE DISEASE. Hall, Herbert E. (Robert A. Taft Sanitary Engineering Center, Cincinnati, Ohio), Robert Angelotti, Keith H. Lewis, and Milton J. Foter. Characteristics of Clostridium perfringens strains associated with food and food-borne disease. J. Bacteriol. 85:1094-1103. 1963.-A total of 83 strains of Clostridium perfringens-30 from England, Europe, and Asia, associated with food-poisoning outbreaks; 28 from the United States, associated with outbreaks or contaminated foods; and 25 from natural or pathological sources-have been studied to determine their serological relationships, sporulation and heat-resistance of spores, and their hemolytic activity on mammalian bloods. A comparison of the results obtained with these three groups of strains reveals that the Eurasian group is characterized by serological typability, poor sporulation with the production of heat-resistant spores, and a hemolytic activity limited to the production of partial hemolysis on horse, ox, and sheep bloods, whereas the strains from natural and pathological sources in this country are not serologically typable, sporulate well but the spores are not heat-resistant, and are hemolytically active, producing both partial and complete hemolysis on horse, ox, and sheep bloods. The American food-poisoning strains have a wide variety of characteristics. Some strains resemble the Eurasian in their serological typability and the production of heat-resistant spores, but sporulation and hemolytic activity are more like the strains from classical sources. On the basis of these data, it appears unlikely that C. perfringens food-poisoning outbreaks in the United States are restricted to strains meeting the criteria of classification described by British workers and that the isolation of large numbers of any strain of this organism from an incriminated food must be considered as having a possible bearing on the etiology of the outbreak.