CLOSTRIDIUM RUBRUM SP. N. AND OTHER PECTINOLYTIC CLOSTRIDIA FROM SOIL. Ng, Henry (University of California, Davis) and Reese H. Vaughn. Clostridium rubrum sp. n. and other pectinolytic clostridia from soil. J. Bacteriol. 85:1104-1113. 1963.-Reports in the literature and results of experiments described herein suggest that pectinolytic anaerobes constitute a very heterogeneous group. The cultures isolated in this study all belonged to the genus Clostridium. The following species were identified: C. butyricum, C. fallax, C. multifermentans, and C. indolis. In addition, a species believed to be previously undescribed was named C. rubrum sp. n. The ability to ferment galacturonic acid was found to be adaptive. Some cultures fermented pectin and pectic acid to the same degree, whereas others fermented pectin only partially. The partial fermentation was attributed to the lack of a pectinesterase. On the basis of fermentation balances, it was concluded that the four strains of galacturonic acid fermenters selected for study yielded identical end products in approximately the same proportions. Per mole of galacturonic acid fermented, about 2 moles of CO(2), 1.5 moles of H(2), 1.5 moles of acetic acid, and 0.25 mole of butyric acid were produced.


VIABILITY OF COLIFORM BACTERIA IN ANTARCTIC SOIL. Boyd, William L. (Ohio State University, Columbus) and Josephine W. Boyd. Viability of coliform bacteria in antarctic soil. J. Bacteriol. 85:1121-1123. 1963.-The distribution of coliform bacteria in soils of Ross Island and the nearby mainland was studied. None was found in almost all of the samples collected, including some from the Adelie penguin rookeries at Cape Royds and Cape Crozier and in soil at the McMurdo Base which had been recently contaminated by human sewage. Samples of pony manure left from previous expeditions were also negative, with one exception where Escherichia coli were present. Studies carried out with two freshly isolated human strains of E. coli and the isolate from pony manure showed that the death rate was extremely rapid, although the animal strain was much more resistant to the various factors of the environment causing death.


ROLE OF FERREDOXIN IN THE METABOLISM OF MOLECULAR HYDROGEN. Valentine, R. C. (University of Illinois, Urbana) and R. S. Wolfe. Role of ferredoxin in the metabolism of molecular hydrogen. J. Bacteriol. 85:1114-1120. 1963.-The metabolism of molecular hydrogen by Clostridium pasteurianum, Micrococcus lactilyticus (Veillonella alcalescens), and several other anaerobic bacteria was studied. Oxidation of hydrogen, using several electron-accepting substrates including triphosphopyridine nucleotide, uric acid, xanthine, nitrite, and hydroxylamine, required ferredoxin in conjunction with hydrogenase. Evolution of hydrogen from pyruvate, alpha-ketoglutarate, hypoxanthine, and dithionite was mediated by ferredoxin. On the basis of these findings, a unitary hypothesis for biological hydrogen evolution is proposed in which ferredoxin plays a key role.


INHIBITION OF YEASTS BY A  MARINE BACTERIUM. Buck, John D. (University of Miami, Miami, Fla.), Donald G. Ahearn, Frank J. Roth, Jr., and Samuel P. Meyers. Inhibition of yeasts by a marine bacterium. J. Bacteriol. 85:1132-1135. 1963.-Although investigations have shown the widespread occurrence of yeasts in the marine environment, notably members of the genus Rhodotorula, studies of a marine amphipod community revealed few, if any, pink yeasts. A gram-negative bacterium (designated AEB, a member of the genus Pseudomonas) isolated from the amphipod habitat showed marked selective ability to inhibit yeasts of both terrestrial and marine origin. Activity was demonstrated with both live cultures of the bacterium and untreated cell-free filtrates. Variously extracted and treated filtrates of the isolate have shown divergent patterns and spectra of inhibition of species of the genus Rhodotorula and of other genera.


GLYCOLIC ACID OXIDATION BY ESCHERICHIA COLI ADAPTED TO GLYCOLATE. Furuya, Akira (University of Illinois College of Medicine, Chicago) and James A. Hayashi. Glycolic acid oxidation by Escherichia coli adapted to glycolate. J. Bacteriol. 85:1124-1131. 1963.-A procedure is described for extraction and partial purification of glycolic acid oxidase from Escherichia coli adapted to grow on glycolate as the sole carbon source. Enzyme activity was assayed by oxygen uptake and by reduction of 2,6-dichlorophenol-indophenol. Glyoxylic acid was the product of glycolate oxidation by the enzyme. Enzyme activity, which diminishes rapidly on storage, shows a maximum at pH 6 to 7. We were unable to show any cofactor requirement. Compounds which inhibited glycolate oxidation and their order of inhibitory activity were: p-hydroxymercuribenzoate > sodium azide > iodoacetate and o-phenanthroline > ethylenediaminetetraacetic acid. Tests of enzyme specificity showed that the following compounds were oxidized, but at different rates: glycolate, d-lactate, l-lactate, dl-alpha-hydroxybutyrate, dl-malate, and dl-glycerate. Citrate, tartrate, and dl-beta-hydroxybutyrate were not oxidized. Potassium cyanide stimulated oxygen uptake when glycolate and lactate were oxidized. Whether the oxidations were due to different oxidases or to a single oxidase with a wide range of specificities was tested by observing the oxidation of glycolate, d-lactate, and l-lactate under various conditions. Ammonium sulfate fractionation of a crude extract did not change the relative ability to oxidize the three acids. However, the three oxidative capacities diminished at different rates during storage at 0 C for 6 days. The partially purified glycolic oxidase preparations were probably mixtures of several different oxidases.


SELECTIVE INHIBITION OF PROLINE-INDUCED PIGMENTATION IN  WASHED CELLS OF SERRATIA MARCESCENS. Blizzard, John L. (University of Houston, Houston, Texas) and G. E. Peterson. Selective inhibition of proline-induced pigmentation in washed cells of Serratia marcescens. J. Bacteriol. 85:1136-1140. 1963.-Streptomycin, chloramphenicol, and tetracyclines inhibited the synthesis of prodigiosin by Serratia marcescens strain D1. This occurred at concentrations of the antibiotic too low to inhibit the growth of the organism in either agar media or broth cultures. Nonpigmented cells were produced in broth by either adding streptomycin or incubating at 37 C. After being washed and resuspended in aqueous saline containing either casein hydrolysate, l-proline, or a glycine-succinate mixture and incubated at 27 C for 24 hr, these cells formed pigment. The appearance of pigment was preceded by a lag period of 10 hr. Prodigiosin production by these washed suspensions of cells was completely inhibited by either streptomycin or glucose, or by incubation at 37 C instead of 27 C. Even though pigmentation by washed-cell suspensions was induced by proline, the utilization of proline was not affected by streptomycin or glucose, or by incubation at 37 C. To block pigmentation completely, streptomycin had to be added to proline-supplemented cells before they were 10 hr old. Addition of the antibiotic after the end of the induction period caused either partial or no inhibition of pigment production. Streptomycin caused an increase in the endogenous respiration of S. marcescens but failed to affect the constitutive enzymes that oxidize glucose. The possible relationships of these phenomena are discussed. Weil (1952) reported that low concentrations of chloramphenicol and certain tetracyclines inhibit the synthesis of prodigiosin while permitting growth by Serratia marcescens. He noted the potential value to "mode-of-action" studies of an organism having certain functions selectively inhibited by antibiotics. We confirmed Weil's (1952) observations and found that streptomycin at low concentration would also inhibit the synthesis of prodigiosin without impeding growth. Further studies of the selective inhibition of prodigiosin synthesis by streptomycin were performed using nonproliferating suspensions of washed cells (Gott and Williams, 1961). Either a glycine-succinate mixture or l-proline could cause nonproliferating cells to form pigment. A period of induction preceded the formation of pigment. Either streptomycin or glucose, or an incubation temperature of 37 C, inhibited the proline-induced pigmentation by washed cells. Further investigations provided insights to these findings.


TURBIDITY CHANGE DURING GLUCOSE PERMEATION IN ESCHERICHIA COLI. Rogers, Dexter (Utah State University, Logan) and Shon-Hua Yu. Turbidity change during glucose permeation in Escherichia coli. J. Bacteriol. 85:1141-1149. 1963.-In contrast to the normal turbidity decrease, which was observed at pH 5.5, the turbidity of suspensions of Escherichia coli strain A (Weigle) increased during uptake of glucose permease substrates when uptake was studied at pH 6.5. Although the turbidity increase at pH 6.5 was the reverse of the expected change, it correlated with the uptake of substrate. During the later phase of permeation at pH 6.5, both uptake of substrate and turbidity change were reversed. We suggest that the observed turbidity response indicated the accumulation of substrate at the cell membrane when the mechanism for releasing substrate to the cytoplasm was inhibited at pH 6.5. Under this condition, uptake of substrate did not cause swelling because the substrate was osmotically inactive, since it may have been bound to the membrane. Permeability was observed to be susceptible to modification by prior treatment with substrate, by aging in the presence of chloramphenicol, and by treatment with dinitrophenol. Permeation and turbidity change are discussed in terms of a proposed phosphorylative mechanism of glucose transport.


EFFECT OF ADJUVANTS ON ANTIBODY RESPONSE OF RABBITS  INOCULATED WITH VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS. Shepel, Michael (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.) and Maxwell R. Klugerman. Effect of adjuvants on antibody response of rabbits inoculated with Venezuelan equine encephalomyelitis virus. J. Bacteriol. 85:1150-1155. 1963.-Hemagglutination-inhibition, neutralization, and complement-fixation tests were performed on sera of rabbits inoculated with Venezuelan equine encephalomyelitis (VEE) virus in combination with Freund's adjuvants and in Hank's salt solution. This study indicated that the complete adjuvants (i.e., with mycobacteria) considerably increased the antibody response to VEE virus. Mycobacterium butyricum (M. smegmatis) appeared to be more effective than M. tuberculosis H37Ra. In the absence of mycobacteria, the response was much less pronounced. Paper electrophoretic studies of the antisera demonstrated a marked increase in gamma-globulin production, an increase in the beta-globulin, and an increase in total protein as the result of adding VEE virus to the complete adjuvants. A decrease in the albumin fraction appeared to be caused by the complete adjuvants rather than by the VEE virus itself. The incomplete adjuvant (without mycobacteria) plus virus contributed little, if any, stimulation toward the production of gamma-globulin, nor did it appear to affect the serum-albumin levels.


VITAMIN REQUIREMENTS OF LISTERIA MONOCYTOGENES. Welshimer, H. J. (Medical College of Virginia, Richmond). Vitamin requirements of Listeria monocytogenes. J. Bacteriol. 85:1156-1159. 1963.-Semidefined and completely defined media were used to determine the growth response of Listeria monocytogenes to several vitamins. All strains tested failed to grow for more than one or two passages in the absence of any one of the following vitamins: riboflavine, biotin, thiamine, and thioctic acid. The thioctic acid requirement and the antagonistic effect of its analogue, 8-methylthioctic acid, could be modified by altering the thiamine concentration.


KINETICS OF THE ACTION OF AMPICILLIN ON ESCHERICHIA COLI. Seligman, Stephen J. (University of California, Los Angeles) and William L. Hewitt. Kinetics of the action of ampicillin on Escherichia coli. J. Bacteriol. 85:1160-1164. 1963.-The curve of the number of viable Escherichia coli after exposure to ampicillin can be divided into three phases: a lag phase, a rapid bactericidal phase, and a slow bactericidal phase. Some of the variables affecting the magnitude of the first two of these phases were investigated. Progressive lowering of drug concentration resulted in prolongation of the lag phase and decrease in slope and extent of the rapid bactericidal phase. The production of elongated gram-negative forms and the emergence of a mutant with increased penicillinase activity complicated interpretation of the lower dose curves. With sufficient drug concentration, the length of the lag phase and the slope of the rapid bactericidal curve were independent of the size of inoculum up to 10(8) organisms. Varying pH revealed that maximal activity, as measured by the shortest lag phase and steepest slope of the rapid bactericidal phase, was present at slightly acid pH levels. Increasing pH resulted principally in prolongation of lag phase. With greater acidity, decrease in slope of the rapid bactericidal phase was more prominent. Cultures studied under conditions of lessened metabolic activity exhibited prolonged lag phase and decreased slope and extent of rapid bactericidal phase.


SIMPLE AND RAPID METHOD FOR DEMONSTRATING MICROBIAL CAPSULES BY PHASE-CONTRAST  MICROSCOPY.


CONVERSION OF THE PHASE I  ANTIGEN OF COXIELLA BURNETII TO HAPTEN BY PHENOL TREATMENT. Anacker, R. L. (Rocky Mountain Laboratory, Hamilton, Mont.), W. T. Haskins, D. B. Lackman, E. Ribi, and E. G. Pickens. Conversion of the phase I antigen of Coxiella burnetii to hapten by phenol treatment. J. Bacteriol. 85:1165-1170. 1963.-Trichloroacetic acid extracts of Coxiella burnetii are converted to hapten by treatment with phenol. Such extracts react, like the original trichloroacetic acid extract, at high dilution in the complement-fixation test and produce zones of precipitate with specific antibody in gel diffusion tests; but, unlike the parent extract, injection of the phenol-treated extract neither induces resistance to challenge in guinea pigs nor antibody formation in guinea pigs, rabbits, or mice. This loss of antigenicity is correlated with removal of protein from the original product.


SIMPLE METHOD FOR DEMONSTRATING MYXOBACTERIAL SLIME.


LIPIDS AND LYSOZYMIC LYSIS OF ACHROMOBACTER.


EFFECT OF ARGININE ON GROWTH AND LYSIS OF CLOSTRIDIUM  BOTULINUM.


AEROBACTER (ENTEROBACTER) CLOACAE IN HUMAN AND ANIMAL FECES.


TRANSMISSION OF A RESISTANCE TRANSFER FACTOR FROM ESCHERICHIA COLI  TO 2 SPECIES OF PASTEURELLA.


ESTIMATION OF ELASTOLYTIC ACTIVITY OF STRAINS OF PSEUDOMONAS  AERUGINOSA.


RICKETTSIAE SMEARS FOR STUDENTS OF MICROBIOLOGY.


INHIBITION OF GROWTH OF TETRAHYMENA PYRIFORMIS BY  OXAMIC ACID.


COMPARISON OF TWO MEDIA FOR THE DETECTION OF THE EGG  YOLK FACTOR OF STAPHYLOCOCCUS AUREUS.


EFFECT OF RELATED ANIONIC DETERGENTS ON STAPHYLOCOCCAL PENICILLINASE.


DETERMINATION OF CARBOHYDRATE METABOLISM OF MARINE BACTERIA.


FREE RADICAL FORMATION AND SURVIVAL OF  LYOPHILIZED MICROORGANISMS. Heckly, Robert J. (University of California, Berkeley), R. L. Dimmick, and J. J. Windle. Free radical formation and survival of lyophilized microorganisms. J. Bacteriol. 85:961-966. 1963.-A correlation between death and spontaneous free radical production, measured by an increase in the relative electron paramagnetic resonance (EPR) signal, was shown to exist for several species of microorganisms stored in the freezedried state, but the relationship between the free radical concentration and number of dead cells was not a simple proportion. Lactose added to Sarcina lutea reduced radical production and increased stability when dry preparations were stored in air. Death and free radical formation were more extensive when lyophilized Streptococcus lactis cultures were stored in air than in vacuum. Free radicals were also produced by dry yeast. Few, if any, free radicals were produced by bacteria or yeast stored in vacuum. It was shown that the observed free radical production was not caused by exposure to light. The EPR signal produced by dry Serratia marcescens decreased rapidly when cells were exposed to a humid atmosphere but the EPR signal slowly increased after cells were redried and exposed to oxygen.


METABOLIC ROLE OF THE BR FACTOR IN BUTYRIBACTERIUM  RETTGERI. Kline, Leo (University of California, Berkeley), L. Pine, and H. A. Barker. Metabolic role of the BR factor in Butyribacterium rettgeri. J. Bacteriol. 85:967-975. 1963.-The BR factor, which is replaceable by lipoic acid, was shown to be required for the decomposition of lactate by Butyribacterium rettgeri. Since the factor was not required for the fermentation of pyruvate or glucose by this organism, the results indicate that BR factor is essential only for some reaction involved in the oxidation of lactate to pyruvate, possibly the transport of electrons from lactate to the ultimate anaerobic electron-acceptor systems. The same products, namely, acetate, butyrate, and carbon dioxide, are formed from glucose or pyruvate in the presence or absence of BR factor and from lactate in the presence of the factor. Thus the factor is not required for the conversion of glucose or pyruvate to acetate, butyrate, or carbon dioxide. Although B. rettgeri does not require the BR factor for growth on glucose, growth of lactate-adapted cells on glucose is slow and is markedly stimulated by addition of the factor. Such cells growing on glucose do not show any ability to decompose lactate; consequently, an additional function of the BR factor, probably associated with the conversion of glucose to pyruvate, is indicated. Cells fully adapted to glucose grow rapidly on this substrate and do not respond to the factor. Lactate is formed during growth of glucose-adapted cells on glucose, although such cells cannot decompose lactate.


NUTRITION OF LEPTOSPIRA POMONA. II. FATTY ACID REQUIREMENTS. Johnson, R. C. (Fort Detrick, Frederick, Md.) and N. D. Gary. Nutrition of Leptospira pomona. II. Fatty acid requirements. J. Bacteriol. 85:976-982. 1963.-The albumin fraction of rabbit serum, obtained by (NH(4))(2)SO(4) fractionation, supported good growth of Leptospira pomona Wickard when added to a medium containing phosphate buffer, NH(4)Cl, and thiamine. Extraction of the albumin fraction with ethanol and ether (3:1) resulted in a loss of its growth-supporting activity, which could be restored upon the addition of the extract or various fatty acids. The growth-supporting activity of fatty acids containing 2 to 18 carbon atoms was investigated with the extracted albumin medium. The activity of the fatty acid was found to be related to the number of carbon atoms in the molecule. Maximal growth was obtained with palmitic, heptadecanoic, stearic, and oleic acids. The amount of growth of L. pomona increased at a fixed concentration of albumin as the molecular ratio of extracted albumin to the long-chain fatty acids increased from 1:1 to 1:6. At higher ratios, growth decreased sharply. Direct utilization of fatty acids during growth of L. pomona was shown by the incorporation of palmitic acid-1-C(14) or -2-C(14) into cellular material. A medium composed of 0.02 m Na(2)HPO(4)-KH(2)PO(4) buffer (pH 7.4), 0.8% extracted albumin, 4 x 10(-4)m palmitic acid, 10(-3)m NH(4)Cl, and 5 mug/ml of thiamine supported good growth. L. pomona was transferred ten times, and seven other serotypes were transferred five times, in this medium without any decrease in the amount of growth. Growth of L. pomona was initiated with approximately four organisms per ml.


NUTRITION OF LEPTOSPIRA POMONA. III. CALCIUM, MAGNESIUM, AND  POTASSIUM REQUIREMENTS. Johnson, R. C. (Fort Detrick, Frederick, Md.) and N. D. Gary. Nutrition of Leptospira pomona. III. Calcium, magnesium, and potassium requirements. J. Bacteriol. 85:983-985. 1963.-The cation requirements for Leptospira pomona Wickard were investigated employing a basal medium prepared with 10% deionized rabbit serum and containing 10(-3)m NH(4)Cl, 5 mug/ml thiamine, and 0.01 m Na(2)HPO(4) buffer (pH 7.4). Rabbit serum was deionized by passage through a column of Amberlite IRC-50 resin. This basal medium did not support growth when either Ca(++) or Mg(++) was added to it. However, when both Ca(++) (3 x 10(-5)m) and Mg(++) (5 x 10(-6)m) were present, growth was obtained. Although an absolute requirement for K(+) could not be demonstrated, an increase in the amount of growth did occur if K(+) (5 x 10(-5)m) was incorporated in addition to Ca(++) and Mg(++). When adequate concentrations of Ca(++) and K(+) were present with a limiting concentration of Mg(++) (less than 5 x 10(-7)m), filamentous cells were observed.


SEROLOGICAL CHARACTERIZATION OF PATHOGENIC FUNGI BY MEANS OF  FLUORESCENT ANTIBODIES. I. ANTIGENIC RELATIONSHIPS BETWEEN YEAST AND MYCELIAL FORMS OF  HISTOPLASMA CAPSULATUM AND BLASTOMYCES DERMATITIDIS. Kaufman, Leo (Communicable Disease Center, Atlanta, Ga.) and William Kaplan. Serological characterization of pathogenic fungi by means of fluorescent antibodies. I. Antigenic relationships between yeast and mycelial forms of Histoplasma capsulatum and Blastomyces dermatitidis. J. Bacteriol. 85:986-991. 1963.-Four antiglobulins prepared against the yeast and mycelial forms of Histoplasma capsulatum and Blastomyces dermatitidis were labeled with fluorescein isothiocyanate. Cross-staining and adsorption techniques enabled the discernment of five antigenic factors in the fungi studied. The yeast-phase cells of H. capsulatum and B. dermatitidis contained the respective distinct antigens B and D, and a common factor E. In addition, the yeast-phase cells of these two species shared antigen C with the mycelial elements of H. capsulatum. The mycelial cells of H. capsulatum and B. dermatitidis shared antigen A with the yeast-phase cells of these two organisms and contained no distinct antigens.


CHEMICALLY DEFINED MEDIUM FOR SOME MICROAEROPHILIC VIBRIOS. Fletcher, R. D. (University of Connecticut, Storrs) and W. N. Plastridge. Chemically defined medium for some microaerophilic vibrios. J. Bacteriol. 85:992-995. 1963.-The medium described supported growth of 22 of 26 catalase-positive, H(2)S-negative vibrios (Vibrio fetus). The strains used were isolated from cattle, chickens, man, sheep, and swine; 10 failed to grow in thiol medium plus 1% glycine (group I), and 16 were glycine-tolerant (group II). Growth on the defined medium was compared with growth on yeast extract agar, blood agar, and thiol agar. Four of the group I strains failed to grow on the defined medium, and growth of seven of the group II strains equaled or exceeded growth obtained on the compared media. Use of synthetic media for determining growth requirements and for possible classification of vibrios is discussed.


INTERACTION OF AN INTERFERON WITH L CELLS. Lockart, Royce Z., Jr. (The University of Texas, Austin) and Barbara Horn. Interaction of an interferon with L cells. J. Bacteriol. 85:996-1002. 1963.-Data were presented on the effect of time of exposure and concentration of an interferon in provoking viral inhibition in L cells. Populations of L cells which made reduced amounts of Western equine encephalomyelitis virus as a result of treatment with interferon did so at reduced rates proportional to the concentration of interferon used. Virus yields were maximal, however, 25 hr after challenge regardless of the amount of virus produced. Such populations of cells contained a proportion of cells no longer able to produce infective virus, while the average maximal yield of the remainder of the cell population was reduced. It was suggested that only cells which made new virus underwent cytopathic effects. The rate of viral inhibition in monolayers of L cells was dependent on the concentration of interferon added, but inhibition was nearly maximal at 8 hr, regardless of the interferon concentration. Viral inhibition was shown to persist in multiplying cells, but it gradually diminished. The amount of inhibition after either one or two cell divisions was greater in those cultures treated with greater amounts of interferon. Viral inhibition could be passed through cell division with no loss when cells were incubated with a sufficient concentration of interferon. A model of interferon action based on the preceding data was presented.


A CYTOLOGICAL AND HISTOLOGICAL STUDY OF ACUTE PREMYELOCYTIC LEUKAEMIA. Among the acute leukaemias of the granulocytic group, acute premyelocytic leukaemia is distinguished by the severity of its haemorrhages, the frequency of hypofibrinaemia, a rapidly fatal course, and an unusual cellular hyperplasia. Myelograms show an increased proportion (average 80%) of characteristic cells of large diameter, with numerous azurophil granules. The infiltration of other organs is inconstant.


AGGLUTINATION REACTIONS OF HUMAN LEUCOCYTES. Agglutination tests with various sera and leucocytes from 58 leukaemic patients and 61 patients without leukaemia are reported. The agglutination of white blood cells by guinea-pig serum is of limited value in the diagnosis of leukaemia, though the test may be helpful in distinguishing leukaemia from other lymphomatous disorders.Leuco-autoagglutinins were demonstrated more frequently than expected. Eleven leukaemic and six non-leukaemic sera agglutinated autologous leucocytes. White blood cell agglutinins showed no apparent relationship to maturity or numbers of circulating leucocytes or to previous blood transfusions, x-irradiation, or therapy with antimetabolites.


CELLULAR TYPES IN ACUTE LEUKAEMIA: DIAGNOSIS AND SIGNIFICANCE. Two independent observers, one using haematological and the other histological methods, analysed material from 68 patients with acute leukaemia. A correct diagnosis of the cell type of leukaemia was made in 70% of cases by haematological methods, and in 83% of those cases histological examination gave the same result. In two-thirds of the haematologically equivocal cases histological examination provided a positive diagnosis. The finally undiagnosed cases amounted to 12% of the total. The types so diagnosed could not be correlated with any clinical features. Differentiation of the cell types in acute leukaemia showed that children with granulocytic types of acute leukaemia survived for shorter periods than those with other types but in adults the type of cell had no significance when related to survival. In adults the immediate prognosis for all cell types was relatively bad. The unfavourable prognosis attached to a high initial leucocyte count was confirmed.


INHERITED ENZYME DEFECTS: A REVIEW.

INHERITED ENZYME DEFECTS: A REVIEW.


FETAL HEPATIC NECROSIS IN GLANDULAR FEVER. A young man of 24 developed glandular fever, became jaundiced, and died in hepatic coma. At necropsy massive necrosis of the liver was found, thus emphasizing that all grades of severity of liver damage may occur in infectious mononucleosis.


A STUDY OF THE VESICAL GANGLIA IN CHILDREN AND THE RELATIONSHIP TO THE MEGAURETER MEGACYSTIS SYNDROME AND HIRSCHSPRUNG'S DISEASE. A method for the assay of vesical ganglion cells is described and the number and distribution of the neurones in three normal bladders was studied. Vesical ganglion counts were done in cases of the megaureter-megacystis syndrome, megaureter, bladder neck obstruction, megacystis associated with absent abdominal muscles, Hirschsprung's disease, and lumbar myelomeningocoele. A normal complement of neurones was found in each case. No evidence was found that the megaureter-megacystis syndrome is due to an agenesis of the peripheral autonomic ganglia similar to that in Hirschsprung's disease. Vesical ganglia were normal in the two cases examined and no clinical association was found between the two conditions in a large series of cases. Moreover, a study of the cell counts suggests that at least some of the reports of such a lesion are based upon an inadequate appreciation of the number and distribution of neurones in the normal urinary tract.


FOUR CASES OF WALDENSTROEM'S MACROGLOBULINAEMIA. The clinical course and pathological features of four cases of Waldenström's macroglobulinaemia are described. One was associated with a localized carcinoma of the bronchus and one with a chromophobe adenoma of the pituitary. Trypsin digest preparations of the retina were examined in two cases, one with severe retinopathy and the other with no clinical evidence of ocular disease, and the findings are briefly described. The aetiology of the anaemia is discussed. Haemolysis due to circulating autoantibodies was not demonstrated in any of the cases. Erythrophagocytosis was a prominent feature in case 4, of moderate degree in cases 1 and 2, and inconspicuous in case 3. It was not proportionate to the serum macroglobulin levels. The cytological and histological features in all four cases are distinctive, and their value in differential diagnosis is stressed.


SYNERGISM BETWEEN SULPHONAMIDE DRUGS AND ANTIBIOTICS OF THE POLYMYXIN GROUP AGAINST PROTEUS SP. IN VITRO. Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.


A NEW PASTEURELLA SPECIES (?) FROM A WOUND INFECTION. A case of appendicitis is described in which the wound was infected with an organism of the genus Pasteurella. The morphological and biochemical properties of the strain are recorded, and comparison is made with other species of the same genus. It is concluded that this strain may be a new species.


A COMPARISON OF THE MEASUREMENT OF GAMMA GLOBULIN IN CEREBROSPINAL FLUID BY ELECTROPHORETIC AND IMMUNOLOGICAL METHODS. The results of measurement of gamma globulin in the cerebrospinal fluid by electrophoresis and by an immunological technique are compared. In some fluids marked discrepancies were found. Such discrepancies, when substantiated and better understood, may have diagnostic significance.


ELECTROPHORETIC PATTERNS OF TUMOUR TISSUE PROTEINS. A method of constructing pherograms is described. The study of electrophoretic patterns shown on pherograms of tumour tissue from man and animals is claimed to offer a new approach to the identification and classification of tumour tissues.


A RAPID MICRO METHOD FOR RECORDING RED CELL OSMOTIC FRAGILITY BY CONTINUOUS DECREASE OF SALT CONCENTRATION. A single volume of 0.075 ml. of a 1 in 10 dilution of whole blood in isotonic NaCl solution is introduced into a container cell, two walls of which are made of a dialysing membrane. The container cell is introduced into a test tube of distilled water, placed in an instrument which is essentially a colorimeter with a recorder, between the source of light and the photoelectric cell. Dialysis through the membrane results in a continuous decrease in the salt concentration of the medium surrounding the erythrocytes. The measurement of the degree of haemolysis is based on the increasing transparency of the erythrocyte suspension while haemolysis takes place. Recording this increasing light transmission as a function of time, i.e., as a function of decreasing salt concentration, yields the osmotic fragility curve. The automatically recorded curve is obtained in less than 10 minutes.


A NEW PROCEDURE FOR THE IDENTIFICATION OF PNEUMOCYSTIS CARINII CYSTS IN TISSUE SECTIONS AND SMEARS.


SEPARATION OF MYOGLOBIN AND HAEMOGLOBIN ON A COLUMN OF DEXTRAN GEL.


A METHOD FOR APPLYING HAEMOLYSATES ON STARCH BLOCKS FOR ELECTROPHORESIS.


A ROUTINE METHOD FOR STAINING EOSINOPHILS IN SPUTUM.


THE EVALUATION AND MANAGEMENT OF BACKACHE IN GENERAL PRACTICE.


ASPHYXIA NEONATORUM.

ASPHYXIA NEONATORUM.


A CLINICAL INVESTIGATION OF HALOTHANE ANAESTHESIA FOR DENTAL EXTRACTIONS IN CHILDREN.


MEIGS' SYNDROME: A CASE REPORT.

MEIGS' SYNDROME: A CASE REPORT.


THE WORK OF THE GENERAL PRACTITIONER: AN ANALYTICAL SURVEY OF STUDIES OF GENERAL PRACTICE.


THE PERSONAL CHARACTERISTICS OF PEOPLE WHO REQUIRE LATE CALLS.


AN ANALYSIS OF PATIENTS SEEN IN GENERAL PRACTICE OVER A PERIOD OF THREE YEARS.


OBSERVATIONS ON THE TREATMENT OF MULTIPLE SCLEROSIS WITH PROPER-MYL. PRELIMINARY REPORT ON A SMALL SERIES OF CASES OF MULTIPLE SCLEROSIS TREATED WITH LYOPHILIZED YEASTS, IN GENERAL PRACTICE.


A SURVEY OF ENGLISH FOLK MEDICINE.

A SURVEY OF ENGLISH FOLK MEDICINE.


GRAECO-ROMAN MEDICAL AND SURGICAL INSTRUMENTS; WITH SPECIAL REFERENCE TO WALES AND THE BORDER.


AN INTERESTING VARIANT OF BORNHOLM DISEASE.


A NOTE ON THE TREATMENT OF WARTS WITH CHLOROSAL.


RAISING STANDARDS IN GENERAL PRACTICE.

RAISING STANDARDS IN GENERAL PRACTICE.


RECENT ADVANCES IN HUMAN CYTOGENETICS.

RECENT ADVANCES IN HUMAN CYTOGENETICS.


ENDOCRINE DISORDERS IN THE NEWBORN INFANT.


THE ROLE OF HORMONES IN HOMOSEXUALITY.

THE ROLE OF HORMONES IN HOMOSEXUALITY.


ENDOCRINE FACTORS IN FEMALE INFERTILITY.


NOTES ON SOME RENAL AND ALDOSTERONE INTERRELATIONS.


RECENT ADVANCES IN DIABETES MELLITUS.

RECENT ADVANCES IN DIABETES MELLITUS.


THYROID HEART DISEASE.

THYROID HEART DISEASE.


PHEOCHROMOCYTOMA: A CONFERENCE OF THE CARDIOLOGY DEPARTMENT, ALBERT EINSTEIN MEDICAL  CENTER, NORTHERN DIVISION, OCTOBER 12, 1962.


THE TOPICAL USE OF FLUOCINOLONE ACETONIDE CREAM FOR  RELIEF OF VULVAR AND PERINEAL PRURITUS.


POLYTHIAZIDE IN CONGESTIVE HEART FAILURE.


SELECTIVE CEREBELLAR GRANULAR LAYER DEGENERATION: A NONSPECIFIC  PATHOLOGICAL FINDING IN TOXIC STATES.


AGE-RELATED CHANGES OF THE HUMAN UTERUS AND ITS CONNECTIVE TISSUE FRAMEWORK.


A HISTO-CYTOLOGIC STUDY OF THE ADRENAL CORTEX IN MICE AS INFLUENCED BY STRAIN, SEX, AND AGE.


METABOLIC TRENDS AND LIFE SPAN OF RATS LIVING AT 9 C. AND 28 C.


THE EFFECT OF MATERNAL AGE ON TIME OF FIRST LITTERS IN INBRED MICE.


THE PROPERTIES OF ISOLATED HUMAN CARDIAC AGE PIGMENT. II. CHEMICAL AND ENZYMATIC PROPERTIES.


PHYSICAL ILLNESS AND DEPRESSIVE SYMPTOMATOLOGY. II. FACTORS OF LENGTH AND SEVERITY OF ILLNESS AND FREQUENCY OF HOSPITALIZATION.


AUDITORY RESPONSES IN SELECTED ELDERLY MEN.


CHANGES IN PSYCHOLOGICAL TEST PERFORMANCE ASSOCIATED WITH THE NORMAL AGING PROCESS.


CHANGES IN TACHISTOSCOPIC FORM PERCEPTION AS A FUNCTION OF AGE AND INTELLECTUAL STATUS.


LEARNING AND REVERSING A FOUR-CHOICE MULTIPLE Y-MAZE BY RATS OF THREE AGES.


A NOTE ON ANGER AND AGGRESSION IN OLD AGE.


THE RELATIONSHIP BETWEEN AGE AND MEASURES OF ID, EGO, AND SUPEREGO FUNCTIONING.


CURRENT PUBLICATIONS IN GERONTOLOGY AND GERIATRICS.


TRAUMATIC RUPTURE OF THE BILE DUCTS.

TRAUMATIC RUPTURE OF THE BILE DUCTS.


ELECTRICAL ALTERNANS.

ELECTRICAL ALTERNANS.


X-RAY CONFERENCE. TRANS-SPHENOIDAL HYPOPHYSECTOMY BY AU 198 IMPLANT.


INHIBITION OF THE PRIMARY VACCINIAL LESION AND OF DELAYED HYPERSENSITIVITY BY AN ANTIMONONUCLEAR CELL SERUM.


EXUDATIVE OTITIS MEDIA AND THE BLUE DRUM.


MANAGEMENT OF THE TRACHEOSTOMY IN CASES OF TETANUS NEONATORUM TREATED WITH  INTERMITTENT POSITIVE PRESSURE RESPIRATION.


DYSOSTOSIS  MANDIBULO-FACIALIS.

DYSOSTOSIS  MANDIBULO-FACIALIS.


STUDIES ON THE POTENTIATION OF ENDOTOXIN IN MICE BY EXPOSURE TO COLD.


IMMUNOLOGICAL INJURY OF MAST CELLS IN MICE ACTIVELY AND PASSIVELY SENSITIZED TO ANTIGENS FROM TRICHINELLA SPIRALIS.


THE GROWTH OF ASIBI STRAIN YELLOW FEVER VIRUS IN  TISSUE CULTURES. I. SENSITIVITY AND CAPACITY OF TISSUE CULTURES.


FIBROUS DYSPLASIA IN THE BONES OF THE FACE.


OSTEOMA OF THE PARANASAL SINUSES ALONG WITH A CASE REPORT OF AN  ORBITO-ETHMOIDAL OSTEOMA.


IMMUNIZATION AGAINST PLAGUE BY A SPECIFIC FRACTION OF PASTEURELLA PSEUDOTUBERCULOSIS.


HAEMANGIOMA OF THE MASSETER.

HAEMANGIOMA OF THE MASSETER.


A CASE OF ANGIOMA OF THE MAXILLARY SINUS UNDERGOING OSSIFICATION.


STIMULATION OF RESISTANCE TO INFECTION BY LIPOID DERIVED FROM NEISSERIA MENINGITIDIS ENDOTOXIN.


AN UNUSUAL CASE OF ECHINOCOCCUS CYST OF THE TONGUE.


STREPTOCOCCAL M PROTEIN ANTIBODIES.

STREPTOCOCCAL M PROTEIN ANTIBODIES.


INTUSSUSCEPTION OF THE OESOPHAGUS.

INTUSSUSCEPTION OF THE OESOPHAGUS.


DETERMINATION OF CORONARY BLOOD FLOW INDEX BY EXTERNAL SCINTILLATION DETECTION.


THE ASSOCIATION OF THYROID CANCER AND PRIOR IRRADIATION IN INFANCY AND CHILDHOOD.


PARTIAL HEPATECTOMY AND PLASMODIUM BERGHEI IN RATS.


CHANGES IN THE MOUSE'S ENTERIC MICROFLORA ASSOCIATED WITH ENHANCED SUSCEPTIBILITY TO SALMONELLA INFECTION FOLLOWING STREPTOMYCIN TREATMENT.


PRODUCTION AND USE OF IODINE-125.

PRODUCTION AND USE OF IODINE-125.


THE GROWTH OF ASIBI STRAIN YELLOW FEVER VIRUS IN TISSUE CULTURES. II. MODIFICATION OF VIRUS AND CELLS.


EFFECT OF ATMOSPHERIC POLLUTANTS ON SUSCEPTIBILITY TO RESPIRATORY INFECTION. II. EFFECT OF NITROGEN DIOXIDE.


A QUERY INTO THE USE OF TRACER DOSES OF I-131.


THE RELATIVE MEAN TRANSIT TIMES OF RED CELLS AND PLASMA IN THE PORTAL CIRCULATION OF THE DOG.


COMPUTERS IN ACTIVATION ANALYSIS.

COMPUTERS IN ACTIVATION ANALYSIS.


IMPORTANCE OF STOP FLOW TO KIDNEY SCANS.


LOCALIZATION OF BRAIN TUMORS WITH THE POSITRON SCINTILLATION CAMERA.


GINGIVO-STOMATITIS IN LIBYA WITH THE ISOLATION OF COXSACKIE A VIRUSES.


A CLEFT PALATE OVER-DENTURE APPLIANCE.

A CLEFT PALATE OVER-DENTURE APPLIANCE.


TUMOURS OF LYMPHOID TISSUE. LABORATORY INVESTIGATIONS.


ALCOHOLIC HALLUCINOSIS AMONG SERVICEMEN IN CYPRUS.


DENSE BONE ISLANDS IN RIBS.

DENSE BONE ISLANDS IN RIBS.


CRYPTOCOCCAL MENINGO-ENCEPHALITIS.

CRYPTOCOCCAL MENINGO-ENCEPHALITIS.


REACTIONS TO INTRADERMAL T.A.B.T. AND T.A.B. VACCINES.


CHEST DISEASES IN THE ARMY. A SURVEY AT THE CONNAUGHT HOSPITAL IN 1950. II. COMPARISON OF THE GROUPS.


EXERCISE "WADE'S ROAD".

EXERCISE "WADE'S ROAD".


PRESENT VIEWS ON THE SURGERY OF THE STOMACH AND DUODENUM.


SURGERY OF THE ADRENAL GLANDS: CLINICAL ASPECTS AND SURGICAL RESULTS.


SELECTIVE SURGERY FOR PEPTIC ULCER.

SELECTIVE SURGERY FOR PEPTIC ULCER.


THE DIAGNOSIS AND TREATMENT OF HYPERTENSION DUE TO RENAL ARTERIAL STENOSIS.


CARDIOPULMONARY BYPASS WITH DILUTED BLOOD.


THE PLACE OF SURGERY IN FIBROUS DYSPLASIA OF THE JAWS.


PITUITARY DESTRUCTION BY SCREW IMPLANTATION WITH YTTRIUM-90.


THE RESULTS OF OPERATIVE TREATMENT IN OSTEOCHONDRITIS DISSECANS OF THE KNEE JOINT.


THE EFFECT ON CARDIAC OUTPUT OF A  REDUCTION IN ATRIAL VOLUME.


EFFECT OF HYPOTHERMIA ON RED CELL VOLUMES.


AN IMPROVED STOPCOCK ASSEMBLY FOR PHYSIOLOGIC MONITORING.


THORACOTOMY IN PATIENTS OVER THE AGE OF SEVENTY.


CHONDROECTODERMAL DYSPLASIA (ELLIS-VAN CREVELD SYNDROME) WITH BRONCHIAL MALFORMATION AND NEONATAL TENSION LOBAR EMPHYSEMA.


THE SOLITARY PULMONARY NODULE. REPORT OF A COOPERATIVE STUDY OF RESECTED  ASYMPTOMATIC SOLITARY PULMONARY NODULES IN MALES.


THE MEASUREMENT OF REGIONAL BLOOD FLOW.

THE MEASUREMENT OF REGIONAL BLOOD FLOW.


ERYTHROCYTE VOLUMES AFTER PERFUSION WITH HOMOLOGOUS BLOOD.


RIGHT VENTRICULAR ANEURYSM. A REVIEW OF THE LITERATURE AND REPORT OF A CASE OF SUCCESSFUL REPAIR WITH THE AID OF TEMPORARY CARDIOPULMONARY BYPASS.


CLOSED PULMONARY VALVOTOMY FOR THE RELIEF OF FALLOT'S TETRALOGY IN INFANCY.


TRAUMATIC MITRAL INSUFFICIENCY FOLLOWING TRANSVENTRICULAR DILATATION FOR MITRAL STENOSIS.


FROZEN-IRRADIATED HOMOGRAFTS SHIELDED WITH MICROFILTER SHEATHS IN PERIPHERAL NERVE SURGERY.


EFFECTS ON CARDIAC FUNCTION DURING DIRECT PERFUSION OF THE NORMAL OR ISCHEMIC VENTRICULAR MYOCARDIUM WITH SATURATED OR UNSATURATED BLOOD OR COLLOIDAL ISOTONIC SOLUTIONS. A PRELIMINARY REPORT.


THE FUNCTION OF THE PATHOLOGIST IN AIRCRAFT ACCIDENTS.


THE MANAGEMENT OF CHYLOTHORAX RELATED TO TRAUMA.


THE MEDICAL SELF-HELP TRAINING PROGRAM.

THE MEDICAL SELF-HELP TRAINING PROGRAM.


EMERGENCY CARE OF CRITICALLY INJURED.

EMERGENCY CARE OF CRITICALLY INJURED.


THE TRAUMA PATIENT VS. EMERGENCY CARE: THE ROLE OF THE EMERGENCY HOSPITAL.


A PRACTICAL METHOD OF RENAL HYPOTHERMIA.


DISPLACED INTRACAPSULAR FRACTURE OF THE NECK OF THE FEMUR. II. RESULTS.


THE INDICATIONS FOR METALLIC IMPLANTS IN CLOSED ADULT FRACTURES.


AMBULANCES ARE MORE THAN VEHICLES.

AMBULANCES ARE MORE THAN VEHICLES.


SEQUELAE OF ACUTE INCREASE IN INTRACRANIAL PRESSURE.


HYDRONEPHROSIS IN INFANTS WITH MENINGOMYELOCELE: ITS EARLY RECOGNITION.


MEASUREMENT OF RENAL FUNCTION IN HEMORRHAGIC HYPOTENSION: EFFECT OF MANNITOL.


MANNITOL DIURESIS: A METHOD OF RENAL PROTECTION DURING SURGERY.


EVALUATION OF SURGICAL DECOMPRESSION OF POLYCYSTIC KIDNEYS BY DIFFERENTIAL RENAL CLEARANCES.


STUDIES ON URODYNAMICS: NEW LIGHT ON URETERAL FUNCTION.


FIBROUS POLYP OF URETER.

FIBROUS POLYP OF URETER.


IDIOPATHIC RETROPERITONEAL FIBROSIS.

IDIOPATHIC RETROPERITONEAL FIBROSIS.


MANAGEMENT OF NEUROGENIC BLADDERS SECONDARY TO CORD INJURY.


INVERTED PAPILLOMA OF THE BLADDER.

INVERTED PAPILLOMA OF THE BLADDER.


UROGENITAL RHABDOMYOSARCOMA: HISTOGENESIS AND CLASSIFICATION.


THE RECTOSIGMOID BLADDER AS A METHOD OF URINARY DIVERSION.


SECONDARY CYSTECTOMY IN RATS.

SECONDARY CYSTECTOMY IN RATS.


REGENERATION OF THE BLADDER: REVIEW OF LITERATURE AND CASE REPORT.


ONE-STAGE REPAIR OF STRICTURE OF BULBOUS URETHRA.


PEDUNCULATED SOLID POLYP OF POSTERIOR URETHRA.


TESTICULAR PROSTHESIS: MATERIALS, METHODS AND RESULTS.


GERM CELL LOSS IN PRE-PUBERTAL CRYPTORCHID TESTES.


BILATERAL TESTICULAR TUMORS: SPINDLE CELL SARCOMA AND SEMINOMA; CASE REPORT.


THE GROWTH OF SERTOLI CELL TUMORS: A POSSIBLE INDEX OF DIFFERENTIAL GONADOTROPHIN ACTIVITY IN THE MALE.


TRANSURETHRAL PROSTATIC RESECTION IN A PATIENT WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA.


RETROPERITONEAL NEUROBLASTOMA: EXPERIENCE IN TWENTY-EIGHT CASES.


INTRODUCTION OF CYSTOSCOPES INTO FEMALE PATIENTS WITHOUT CONTAMINATING THE GLOVED FINGERS.


A NEW DYNAMIC CATHETER-TYPE SPHINCTEROMETER.


A NEW CLAMP FOR USE IN PERINEAL URETHROSTOMY.


IS THIS SYMPTON FUNCTIONAL?

IS THIS SYMPTON FUNCTIONAL?


BENZENE EXPOSURE AND APLASTIC ANEMIA FOLLOWED BY LEUKEMIA 15 YEARS LATER.


ROUTINE EVALUATION OF BLEEDING TENDENCY IN SURGICAL PATIENTS. MICRO PARTIAL THROMBOPLASTIN TIME (PTT) TEST.


ABO BLOOD GROUPS AND MULTIPLE CANCERS.

ABO BLOOD GROUPS AND MULTIPLE CANCERS.


METHEMOGLOBINEMIA IN A HOSPITAL NURSERY: A SEARCH FOR CAUSATIVE FACTORS.


URINARY ALKALINE PHOSPHATASE ACTIVITY. I. ELEVATED URINARY LDH AND ALKALINE PHOSPHATASE ACTIVITIES FOR THE DIAGNOSIS OF RENAL ADENOCARCINOMAS.


FDA REPORT ON ENOVID. AD HOC ADVISORY COMMITTEE FOR THE EVALUATION OF A POSSIBLE ETIOLOGIC RELATION WITH THROMBOEMBOLIC CONDITIONS.


BASAL GASTRIC SECRETIONS. A STUDY IN YELLOW-ORANGE FLUORESCENCE.


THE CLINICIAN, HIS STETHOSCOPE, AND ARTERIAL SOUNDS.


HUMANIACS THREATEN RESEARCH.

HUMANIACS THREATEN RESEARCH.


WILLIAM CADOGAN (1711-1797).

WILLIAM CADOGAN (1711-1797).


ROLE OF THE PRIVATE PHYSICIAN IN COORDINATED HOME CARE.


FALSE-POSITIVE SEROLOGY IN MONONUCLEOSIS.


STUDY OF THE PERICARDIUM AND VENTRICULAR MYOCARDIUM. EXPLORATORY MEDIASTINOTOMY AND BIOPSY IN UNEXPLAINED HEART DISEASE.


YOUR PROFESSIONAL LIABILITY: 131 QUESTIONS AND ANSWERS.


AUTOREGULATION--'A PROTECTIVE MECHANISM'.


RECURRENT SPONTANEOUS RUPTURE OF THE BOWEL MANIFESTED BY HEMOPERITONEUM.


GENERALIZED ESSENTIAL TELANGIECTASIA: REPOR OF A CLINICAL AND HISTOCHEMICAL STUDY OF 13 PATIENTS WITH ACQUIRED CUTANEOUS LESIONS.


STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.


THE CYSTIC DUCT SYNDROME.

THE CYSTIC DUCT SYNDROME.


MOUTH-TO-MOUTH RESUSCITATION IN NORWAY.

MOUTH-TO-MOUTH RESUSCITATION IN NORWAY.


CURRENT INTERPRETATION OF THE SODIUM IODOHIPPURATE I-131 RENOCYSTOGRAM.


UREA-INDUCED, OSMOTIC DIURESIS AND ALKALIZATION OF URINE IN ACUTE BARBITURATE INTOXICATION.


HOUSE STAFF EDUCATION ON A PRIVATE MEDICAL SERVICE.


CLINICAL THERMOGRAPHY.

CLINICAL THERMOGRAPHY.


URINARY ALKALINE PHOSPHATASE ACTIVITY. II. AN ANALYTICAL VALIDATION OF THE ASSAY METHOD.


RIGHT LOWER LOBE MASS.

RIGHT LOWER LOBE MASS.


HERMANN LUDWIG FERDINAND VON HELMHOLTZ.

HERMANN LUDWIG FERDINAND VON HELMHOLTZ.


BACTERIAL CONTAMINATION OF INDWELLING INTRAVENOUS POLYETHYLENE CATHETERS.


SERUM TRANSAMINASE LEVELS: EFFECT OF STRENUOUS AND PROLONGED PHYSICAL EXERCISE ON HEALTHY YOUNG SUBJECTS.


CORONARY VASCULAR EFFECTS OF GRISEOFULVIN.


MONDOR'S DISEASE.

MONDOR'S DISEASE.


CORTICOSTEROID THERAPY FOR BOECK'S SARCOID: CORRELATION OF FUNCTIONAL AND RADIOGRAPHIC EVIDENCE OF IMPROVEMENT.


NARCOTICS AND MEDICAL PRACTICE. THE USE OF NARCOTIC DRUGS IN MEDICAL PRACTICE AND THE MEDICAL MANAGEMENT OF NARCOTIC ADDICTS.


A CASE OF DIASTEMATOMYELIA.

A CASE OF DIASTEMATOMYELIA.


DIABETES COMPLICATIONS--CAN THEY BE REVERSED?


STUDIES ON THE PROPAGATION VELOCITY OF THE PULSE WAVE IN CHILDREN. I. HEALTHY  CHILDREN.


STUDIES ON THE PROPAGATION VELOCITY OF THE PULSE WAVE IN CHILDREN. II. HEART  DISEASE.


CLASSIFICATION OF MYCOBACTERIOPHAGE.

CLASSIFICATION OF MYCOBACTERIOPHAGE.


STAPHYLOCOCCUS ENTEROTOXIN: A REVIEW.

STAPHYLOCOCCUS ENTEROTOXIN: A REVIEW.


A ROUTINE TEST PROCEDURE FOR PHAGE TYPING OF MYCOBACTERIA.


STUDIES ON CROSS-RESISTANCE BETWEEN CAPREOMYCIN AND CERTAIN  OTHER ANTI-MYCOBACTERIAL AGENTS.


ON THE DISCOVERY AND PREVALENCE OF SCHISTOSOMA SPINDALE (MONTGOMERY, 1906) IN THAILAND.


INFECTIVITIES OF STRAINS OF JAPANESE B ENCEPHALITIS VIRUS FOR MICE BY INTRAPERITONEAL INOCULATION.


VARIATION OF VIRULENCE OF JAPANESE B ENCEPHALITIS VIRUS TO ADULT MICE.


"TYPICAL" AND "ATYPICAL" SERUM INSULIN-LIKE ACTIVITY IN UNTREATED DIABETES MELLITUS.


FATE OF RAT INSULIN IN RAT-LIVER PERFUSION STUDIED BY ADIPOSE-TISSUE ASSAY.


SEROTONIN IN PLATELETS: ITS UPTAKE AND DISAPPEARANCE AFTER ADMINISTRATION OF THE AMINE BY MOUTH.


GRISEOFULVIN ADMINISTRATION AND PORPHYRIN METABOLISM. A SURVEY.


INHIBITION OF LACTOGENESIS BY COMBINED ORAL PROGESTOGENS AND OESTROGENS.


DIAGNOSIS OF SIGNIFICANT BACTERIURIA IN PREGNANCY.


ISOLATED INTESTINAL LACTASE DEFICIENCY IN THE ADULT.


TREATMENT OF BROMIDE POISONING: COMPARISON OF FORCED HALOGEN TURNOVER AND HAEMODIALYSIS.


THE TREATMENT OF SEVERE ASPIRIN POISONING.


ADULT ENDOMYOCARDIAL FIBROSIS IN BRITAIN.


CLEARANCE FROM PLASMA OF ISOTOPICALLY LABELLED OESTRADIOL IN PATIENTS WITH HEPATIC CIRRHOSIS.


VIRUS ISOLATION, INCLUSION BODIES, AND CHROMOSOMES IN A RUBELLA-INFECTED HUMAN EMBRYO.


FRESH LIGHT ON MYASTHENIA GRAVIS.

FRESH LIGHT ON MYASTHENIA GRAVIS.


CHELATING AGENTS IN WILSON'S DISEASE.

CHELATING AGENTS IN WILSON'S DISEASE.


EMERGENCY TREATMENT OF CARDIAC ARREST.

EMERGENCY TREATMENT OF CARDIAC ARREST.


CORONARY UNIT: AN INTENSIVE-CARE CENTRE FOR ACUTE MYOCARDIAL INFARCTION.


THE ANTI-SMOKING CLINIC.

THE ANTI-SMOKING CLINIC.


A GENETIC THEORY OF INFLAMMATORY POLYARTHRITIS.


MULTIPLE SCREENING.

MULTIPLE SCREENING.


ORIGIN OF BLOOD FIBRINOLYTIC ACTIVITY.

ORIGIN OF BLOOD FIBRINOLYTIC ACTIVITY.


CHARLES MAX PAGE.

CHARLES MAX PAGE.


CHORIODECIDUAL AND MYOMETRIAL BLOOD-FLOW.


MULTIPLE ANTIBODY PRODUCTION IN MYASTHENIA GRAVIS.


A DEEPER LOOK AT THE TRENDELENBURG OPERATION FOR VARICOSE VEINS.


TONGUE TIE.

TONGUE TIE.


TONSILLECTOMY IN PATIENTS WITH COAGULATION DEFECTS.


GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND NEONATAL JAUNDICE IN NIGERIA: THEIR RELATION TO THE USE OF PROPHYLACTIC VITAMIN K.


POLYNEURITIS AND RENAL CARCINOMA.

POLYNEURITIS AND RENAL CARCINOMA.


TOTAL PANCREATECTOMY FOR FULMINANT PANCREATITIS.


FURTHER OBSERVATIONS ON ANTIGEN-INDUCED MITOSIS.


MITOGENIC ACTION OF ANTILEUCOCYTE IMMUNE SERUM ON PERIPHERAL LEUCOCYTES IN VITRO.


HIGH CARBOHYDRATE INTAKE FOR ORAL USE IN ACUTE RENAL FAILURE.


A FIBRE OPTIC FLEXIBLE CESOPHAGOSCOPE.

A FIBRE OPTIC FLEXIBLE CESOPHAGOSCOPE.


PROTRACTED LABOUR.

PROTRACTED LABOUR.


PREOPERATIVE SKIN PREPARATION.

PREOPERATIVE SKIN PREPARATION.


APPOINTMENTS IN GENERAL PRACTICE DOCTOR'S AND PATIENTS' VIEWS.


USING MENTAL HOSPITALS FOR OTHER PURPOSES.


DOCTORS FOR NIGERIA: THOUGHTS AFTER SECONDMENT.


HEALTH CENTRES IN BLACKBURN.

HEALTH CENTRES IN BLACKBURN.


CHROMOSOME ABNORMALITY IN ACUTE LEUKAEMIA.


THE LYON-BEUTLER HYPOTHESIS AND ISOCHROMOSOME X PATIENTS WITH TURNER SYNDROME.


DOWN'S SYNDROME: TRISOMY AND A DE-NOVO TRANSLOCATION IN A FAMILY.


INCIDENCE OF TURNER'S SYNDROME IN JAPANESE DWARFED GIRLS.


HUMAN ANTIHAEMOPHILIC FACTOR.

HUMAN ANTIHAEMOPHILIC FACTOR.


RESPIRATION-RATES AND OXIDATIVE PHOSPHORYLATION OF HEART SARCOSOMES IN KWASHIORKOR.


KARYOTYPING OF CELLS FROM CEREBROSPINAL FLUID.


EFFECT OF CORTICOTROPHIN ON THE RENAL RESPONSE TO POSTERIOR PITUITARY EXTRACT IN RATS.


HYPOPARATHYROIDISM.

HYPOPARATHYROIDISM.


JAMES JOHNSTON ABRAHAM.

JAMES JOHNSTON ABRAHAM.


FREDRIC BATTINSON SMITH.

FREDRIC BATTINSON SMITH.


PRELIMINARY OBSERVATIONS ON TREATMENT OF ADVANCED CANCER BY  INJECTION OF ALLOGENEIC SPLEEN CELLS.


INSULATION IN LEANNESS AND OBESITY.

INSULATION IN LEANNESS AND OBESITY.


PENICILLAMINE AND MIXED DISULPHIDE EXCRETION IN WILSON'S DISEASE.


CUSHING'S SYNDROME CAUSED BY MEDIASTINAL TUMOUR?


AN OUTPATIENT OPERATION FOR HYDROCELE OF THE TUNICA VAGINALIS IN ADULTS.


CHROMOSOME STUDIES IN PATIENTS WITH SUPRAVALVULAR AORTIC STENOSIS.


ISOLATION OF TRACHOMA VIRUS IN THE SUDAN.


ACID MUCOPOLYSACCHARIDES IN HUMAN AORTIC TISSUE: THEIR  DISTRIBUTION AT DIFFERENT STAGES OF ATHEROSCLEROSIS.


WATER.

WATER.


METHOXYFLURANE.

METHOXYFLURANE.


HOSPITAL MEDICINE IN REAL TERMS.

HOSPITAL MEDICINE IN REAL TERMS.


THE MORTALITY OF WIDOWERS.

THE MORTALITY OF WIDOWERS.


NEOMYCIN RESISTANCE IN NEWLY RECOGNISED STRAINS OF STAPHYLOCOCCUS  AUREUS.


(BROWNE FJ),+BROWNE FJ: FRANCIS JAMES BROWNE.


MANAGEMENT OF PAROTID TUMORS.

MANAGEMENT OF PAROTID TUMORS.


ORIENTATION TO MENTAL HYGIENE CONCEPTS.

ORIENTATION TO MENTAL HYGIENE CONCEPTS.


ARMORED DIVISION MEDICAL SERVICE.

ARMORED DIVISION MEDICAL SERVICE.


FOLLOW-UP STUDIES OF THYROIDAL CARCINOMA.


THE JAUNDICED EYE.

THE JAUNDICED EYE.


RESULTS OF SURGICAL TREATMENT IN 100 CONSECUTIVE CASES OF LUMBAR HERNIATED DISC SYNDROME.


AGRANULOCYTOSIS DUE TO ADMINISTRATION OF SALICYLAZOSULFAPYRADINE (AZULFIDINE).


OPERATION IDA.

OPERATION IDA.


RELEASE OF FREE FATTY ACIDS FROM THE ISOLATED EPIDIDYMAL FAT PAD OF OBESE-HYPERGLYCEMIC MICE.


POLYCYCLIC AROMATIC HYDROCARBONS, THEIR ANALOGUES AND DERIVATIVES, AS POTENTIAL PHARMACOLOGICAL AGENTS.


PRELIMINARY STUDIES OF THE DISTRIBUTION AND FATE OF BR82-  LABELLED 2-BROM-D-LYSERGIC ACID DIETHYLAMIDE (BOL) IN THE HUMAN BODY.


PREVENTION BY DIETARY MEANS OF THE DIRECT CALCIFICATION INDUCED BY KMNO4.


ATTEMPTS TO PRODUCE INFLAMMATORY SWELLING WITH OEDEMA FLUID.


INTERACTION OF COCAINE AND G-STROPHANTHIN ON THE MEMBRANE POTENTIAL OF FROG SARTORIUS MUSCLE FIBRES.


INCREASED HISTAMINE FORMATION IN TISSUES FROM BURNED MICE.


ACTION OF NEUROTROPIC DRUGS ON REFLEX GASTRIC WALL DYSTROPHY.


NEUROCHEMICAL TRANSDUCER SYSTEMS.

NEUROCHEMICAL TRANSDUCER SYSTEMS.


OBSERVATIONS ON SOME FUNNEL-WEB SPIDERS (ATRAX SPECIES) AND THEIR VENOMS, WITH PARTICULAR REFERENCE TO ATRAX ROBUSTUS.


MERALGIA PARAESTHETICA.

MERALGIA PARAESTHETICA.


PARATYPHOID A IN MIGRANTS: A PUBLIC HEALTH REPORT.


AN UNUSUAL PROTEIN FRACTION ASSOCIATED WITH CHRONIC OBSTRUCTIVE JAUNDICE.


A NEW OXYTOCIC PREPARATION FOR USE IN THE MANAGEMENT OF THE THIRD STAGE OF LABOUR.


MYCOBACTERIUM ULCERANS INFECTIONS IN THE NORTHERN TERRITORY.


DOCTOR OR COMPUTER?

DOCTOR OR COMPUTER?


MEDICAL EVIDENCE IN THE COURTS.

MEDICAL EVIDENCE IN THE COURTS.


THE CAUSES OF DEATH IN DIABETES MELLITUS.


REPATRIATION ENTITLEMENTS.

REPATRIATION ENTITLEMENTS.


DRUGS AND AUTOMATISM.

DRUGS AND AUTOMATISM.


IDENTIFICATION OF HUMAN BLOODSTAINS BY MEANS OF THE  MIXED ANTIGLOBULIN REACTION ON SEPARATE CLOTH FIBRILS.


THE IDENTIFICATION OF MN GROUPS IN DRIED BLOODSTAINS.


NOTE ON THE POSSIBILITY OF DEMONSTRATING THE GM-FACTORS  IN SEMEN.


DETERMINATION OF THE ABO GROUP FROM FINGERNAILS.


PSEUDO AIR EMBOLISM IN SUSPECTED ABORTION.


THE DIAGNOSIS OF ALCOHOLIC INTOXICATION.


NECROPHILIA: NEED PARLIAMENT TROUBLE?A NOTE ON THE LEGAL ASPECT.


REFLECTIONS OF A GP 1913-1963.

REFLECTIONS OF A GP 1913-1963.


DESIGNING FOR GENERAL PRACTICE: SKETCH PLANS.


OFFICE EQUIPMENT AND ORGANISATION: APPOINTMENTS SYSTEMS.


WHAT I HAVE LEARNED FROM MEDICINE?

WHAT I HAVE LEARNED FROM MEDICINE?


STUDIES ON AN INTERMITTENT CORTICOSTEROID DOSAGE REGIMEN.


THE ALPHA PARTICLE OR PROTON BEAM IN RADIOSURGERY OF THE PITUITARY GLAND FOR CUSHING'S DISEASE.


PATTERNS OF ILLNESS IN RHINOVIRUS INFECTIONS OF MILITARY PERSONNEL.


AN IMPROVED TECHNIC OF EXTERNAL CARDIAC COMPRESSION IN INFANTS AND YOUNG CHILDREN.


MEDICAL CARE: ITS SOCIAL AND ORGANIZATIONAL ASPECTS. TO THE PUBLIC A HOSPITAL IS A HOSPITAL.


GLYCOPROTEINS: STRUCTURE, METABOLISM AND BIOLOGY.


THROMBOEMBOLISM IN PATIENTS RECEIVING PROGESTATIONAL DRUGS.


HAZARDS TO HEALTH; POISONOUS SNAKEBITE.

HAZARDS TO HEALTH; POISONOUS SNAKEBITE.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL. CASE 59-1963.


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL. CASE 60-1963.


STUD GUNS STILL LETHAL.

STUD GUNS STILL LETHAL.


CARDIAC NOISES.

CARDIAC NOISES.


THE PHYSICIAN AND THE MOTORCAR.

THE PHYSICIAN AND THE MOTORCAR.


ANESTHETIC PROBLEMS IN SEVERELY INJURED PATIENTS.


TRAUMATIC CARDIAC AND PERIPHERAL VASCULAR INJURIES.


MANAGEMENT OF HAND INJURIES.

MANAGEMENT OF HAND INJURIES.


DEATH AND INJURY BY DESIGN.

DEATH AND INJURY BY DESIGN.


AUTOMOTIVE SAFETY RESEARCH AT GENERAL MOTORS PROVING GROUND.


ABDOMINAL INJURIES.

ABDOMINAL INJURIES.


CHOLERA.

CHOLERA.


EAR, NOSE AND THROAT EMERGENCIES.

EAR, NOSE AND THROAT EMERGENCIES.


COMMON COLDS.

COMMON COLDS.


BOAC NURSING SERVICE, LONDON AIRPORT.

BOAC NURSING SERVICE, LONDON AIRPORT.


THE PROFESSION'S GOOD NAME.

THE PROFESSION'S GOOD NAME.


TEACHING MACHINES AND PROGRAMMED LEARNING.


PATIENTS WORKING FOR PAY--FURTHER COMMENTS.


THE WIDER BASIC TRAINING: SOME IMPLICATIONS.


THE CENTER OF GRAVITY IN THE PARTS OF HUMAN BODY.


ELECTRON MICROSCOPY OF NERVE FIBERS VII. ON THE ELECTRON DENSE RADIAL COMPONENT IN THE LAMINATED MYELIN SHEATH.


THE STRUCTURE AND THE DEVELOPMENT OF THE CHONDROCRANIUM OF VARANUS. I. THE DEVELOPMENT OF THE ETHMOIDAL REGION.


PELVIC ARTERIES IN MACACUS CYCLOPSIS. I. THE COMMON ILIAC ARTERY AND THE EXTERNAL ILIAC ARTERY.


CULTIVATION OF VIRUS IN A CASE OF SYMPATHETIC OPHTHALMIA.


A PHOTO-ELECTRIC INSTRUMENT FOR MEASURING THE AQUEOUS FLARE IN THE INTACT EYE.


ON THE PHYSIOLOGICAL STANDARDIZATION OF THE LIGHT SOURCE IN ELECTRORETINOGRAPHY.


PEDIATRIC CARDIOLOGY, AND THE SUB-BOARDS.


SIGNS OF PYRIDOXINE DEPENDENCY MANIFEST AT BIRTH IN SIBLINGS.


THE INFLUENCE OF ADRENAL STEROIDS AND CORTICOTROPIN ON MASSIVE MYOCLONIC SEIZURES OF INFANCY.


BLOOD PRESSURE AND VASOMOTOR REFLEXES IN THE NEWBORN INFANT.


MATERNAL RUBELLA AND PULMONARY ARTERY STENOSES. REPORT OF ELEVEN CASES.


SYSTEMIC BLOOD FLOW IN INFANTS AND CHILDREN WITH AND WITHOUT HEART DISEASE.


BICYCLE ERGOMETER STUDIES IN CHILDREN. II. CORRELATION OF PULSE RATE WITH OXYGEN CONSUMPTION.


PULMONARY FUNCTION IN PECTUS EXCAVATUM.

PULMONARY FUNCTION IN PECTUS EXCAVATUM.


INTESTINAL LACTASE DEFICIENCY IN A PATIENT WITH CYSTIC FIBROSIS. REPORT OF A CASE WITH ENZYME ASSAY.


CLINICAL AND BIOCHEMICAL STUDIES ON TWO CASES OF HISTIDINEMIA.


THE DIAGNOSIS OF MAPLE SYRUP URINE DISEASE (BRANCHED-  CHAIN KETOACIDURIA) BY THE IN VITRO STUDY OF THE PERIPHERAL LEUKOCYTE.


PEDIATRIC APPLICATION OF THE RADIOIODINE (I-131) ROSE BENGAL METHOD IN HEPATIC AND BILIARY SYSTEM DISEASE.


VIRILIZATION ACCOMPANYING HEPATOBLASTOMA.


CERVICAL MASSES IN INFANTS AND CHILDREN.


CONTINUOUS INTRAVENOUS INFUSION OF CALCIUM IN VITAMIN D DEFICIENT RICKETS.


HAGEMAN FACTOR DEFICIENCY IN A CHILD.

HAGEMAN FACTOR DEFICIENCY IN A CHILD.


SOME SOCIAL PSYCHOLOGICAL CONSEQUENCES OF HANDICAPPING.


OSTEOCHONDROMATA FOLLOWING IRRADIATION IN CHILDREN.


CHILD-REARING PRACTICES IN A LOW SOCIOECONOMIC GROUP. THE MOTHERS OF PREMATURE INFANTS.


THE INFLUENCE OF URIDINE NUCLEOTIDES UPON THE ISOLATED FROG HEART.


INVESTIGATION OF DENERVATION  SUPERSENSITIVITY IN A SYMPATHETIC GANGLION.


PHARMACOLOGICAL STUDIES ON THE PRIMARY AFFERENT DEPOLARIZATION OF THE  TOAD SPINAL CORD.


EFFECTS OF HYPERCAPNIA ON THE VASCULAR RESISTANCE OF THE DOG'S HIND LIMB.


SUBLIMATION OF IODOCHLOROHYDROXYQUINOLINE.


A CONTRIBUTION TO THE AETHIOPATHOGENESIS OF THE NASAL POLYPS.


ON PATHOLOGICAL SPONTANEOUS AND POSITIONAL NYSTAGMUS.


HISTOPATHOLOGIC CLASSIFICATION OF PERIARTERITIS NODOSA: A STUDY OF 56 CASES CONFIRMED AT NECROPSY.


SYSTEMIC SPOROTRICHOSIS WITH BILATERAL SYNOVITIS IN THE KNEES: REPORT OF A CASE.


SIR RAYMOND CRAWFURD.

SIR RAYMOND CRAWFURD.


SIR D'ARCY POWER.

SIR D'ARCY POWER.


SIR FRANCIS CHAMPNEYS.

SIR FRANCIS CHAMPNEYS.


THE TWO ROLLESTONS AND SIR WALTER  LANGDON-BROWN.


MEDICINE BEFORE A.D. 1500 AS VIEWED BY MEDICAL HISTORIANS DURING THE PAST  FIFTY YEARS.


CONTRIBUTIONS TO THE HISTORY OF SURGERY FROM 1912 TO 1962.


CONTRIBUTIONS TO THE HISTORY OF MEDICINE.


OSLER, THE MEDICAL HISTORIAN.

OSLER, THE MEDICAL HISTORIAN.


DIETETICS AND NUTRITION.

DIETETICS AND NUTRITION.


THE RE-EDUCATIVE TREATMENT OF BOWEL DYSFUNCTION  IN INFANTS AND CHILDREN.


STAPEDECTOMY. A REVIEW OF CONTEMPORARY TECHNIQUES.


THE SURGICAL TREATMENT OF HYDRADENITES SUPPURATIVA.


PRACTICAL THERAPEUTIC DIETETICS. I. ADAPTATIONS OF THE NORMAL DIET.


PHYSICAL FITNESS.

PHYSICAL FITNESS.


THE WINDS OF CHANGE.

THE WINDS OF CHANGE.


PARTIAL NEPHRECTOMY FOR STONES.

PARTIAL NEPHRECTOMY FOR STONES.


TREATMENT OF SPASM OF THE EXTERNAL SPHINCTER REGION OF THE URETHRA.


THE ROLE OF THE UROLOGIST IN THE TREATMENT OF VESICO-VAGINAL FISTULAE.


EXPERIENCES WITH ILEAL AND COLONIC CONDUITS IN THE TREATMENT OF URINARY INCONTINENCE.


CYSTOPLASTY--RESULTS AND EVALUATION OF ALTERNATIVE METHODS.


THE PRESENT POSITION OF EXPERIMENTAL INVESTIGATIONS INTO THE AETIOLOGY OF BLADDER CANCER.


CARCINOMA OF THE PROSTATE. A REVIEW OF VARIOUS METHODS OF TREATMENT.


SURGICAL TREATMENT OF ULCERATIVE COLITIS.


SURVIVAL AFTER MESENTERIC RESECTION FOR BOWEL INFARCTION FROM MESENTERIC VASCULAR OCCLUSION.


ACUTE UPPER GASTROINTESTINAL HEMORRHAGE.


GASTROENTERITIS IN EASTERN SAUDI ARABIA.


PSEUDO-HIRSCHSPRUNG'S DISEASE OF THE ILEUM.


ORAL HYPAQUE SODIUM AS CONTRAST MEDIUM IN GASTROINTESTINAL EXAMINATIONS.


PRIMARY INFARCTION OF OMENTUM.

PRIMARY INFARCTION OF OMENTUM.


THE EFFECT OF RENAL DISEASE ON THE DEGRADATION OF INSULIN.


A NEW VIEW OF DISEASE.

A NEW VIEW OF DISEASE.


ACUTE EXPERIMENTAL PNEUMOCOCCAL (TYPE I) PNEUMONIA IN THE MOUSE: THE MIGRATION OF LEUCOCYTES FROM THE PULMONARY CAPILLARIES INTO THE ALVEOLAR SPACES AS REVEALED BY THE ELECTRON MICROSCOPE.


A DISCOURSE ON NAIL GROWTH AND UNUSUAL FINGERNAILS.


INFLUENCE OF PARATHYROID ACTIVITY ON ION EXCHANGE IN VARIOUS TISSUES.


MYOTONIA DYSTROPHICA.

MYOTONIA DYSTROPHICA.


EVIDENCE AGAINST INFECTIOUS HEPATITIS AS A CAUSE OF CIRRHOSIS.


A CONSIDERATION OF THE ETIOLOGY OF OBSTRUCTIVE EMPHYSEMA, WITH ESPECIAL EMPHASIS ON THE ROLE OF ALLERGY.


TRAUMATIC RUPTURE OF THE GALLBLADDER DUE TO NONPENETRATING INJURY.


ORAGRAFIN AS A SUPPLEMENTAL CONTRAST AGENT IN ORAL CHOLECYSTOGRAPHY.


THE USE OF AZEPINAMIDE IN THE MANAGEMENT OF DIABETES MELLITUS.


TEXAS DOCTOR IN AFGHANISTAN. CONCERN FOR SICK APPRECIATED UNIVERSALLY.


SABIN POLIOMYELITIS VACCINE. PRELIMINARY REPORT-1962.


CLINICOPATHOLOGIC CONFERENCE.

CLINICOPATHOLOGIC CONFERENCE.


DIRECT CURRENT SHOCK IN THE TREATMENT OF CARDIAC ARRHYTHMIAS.


HEMOLYTIC TRANSFUSION REACTIONS AND ACUTE RENAL FAILURE.


"RIGHT-SIDED" MURMURS OF AORTIC INSUFFICIENCY.


INTRACELLULAR GRANULES OF THE RENAL MEDULLA IN POTASSIUM DEPLETION.


THE RELATIONSHIP BETWEEN PEPTIC ULCER AND CORONARY OCCLUSION.


SOME CLINICAL AND CLIMATOLOGICAL ASPECTS OF ALDOSTERONISM IN MAN.


MEMORIAL: THOMAS F. MACHELLA.

MEMORIAL: THOMAS F. MACHELLA.


AN UNEXPECTED CAUSE OF CUSHING'S SYNDROME: CARCINOMAS THAT SECRETE "ACTH".


AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION. DIRECTORY.


MEMORIAL: FREDERICK PARKES WEBER.

MEMORIAL: FREDERICK PARKES WEBER.


MEMORIAL: HUGH JACKSON MORGAN.

MEMORIAL: HUGH JACKSON MORGAN.


MEMORIAL: OLIVER HAZARD PERRY PEPPER.

MEMORIAL: OLIVER HAZARD PERRY PEPPER.


MEMORIAL: FRANCES MARION POTTENGER.

MEMORIAL: FRANCES MARION POTTENGER.


ANTIBIOTICS--SINGLY OR IN COMBINATION?

ANTIBIOTICS--SINGLY OR IN COMBINATION?


EFFECTS OF ASPIRIN AND CORTICOSTEROIDS ON PAGET'S DISEASE OF BONE.


TYPHOID FEVER: A DISCUSSION OF ITS PATHOGENESIS, PHYSIOLOGIC ABNORMALITIES AND MANAGEMENT.


GEORGE HOYT WHIPPLE, NOBEL PRIZE PATHOLOGIST.


EXTINCT MEDICAL SCHOOLS OF NINETEENTH CENTURY PHILADELPHIA: IV. PENN MEDICAL UNIVERSITY.


THE BIRTH OF AMERICAN RHEUMATOLOGY.

THE BIRTH OF AMERICAN RHEUMATOLOGY.


MEMOIR OF MARGARET CASTEX STURGIS (1885-1962).


MEMOIR OF JOSEPH VICTOR KLAUDER (1888-1962).


PREPARATION BY ELUTION FROM SPECIFIC  AGGREGATES OF THE ISOANTIBODY CAUSING REJECTION OF TRANSFERRED RABBIT LYMPH NODE CELLS.


H-5.A AND H-6.A, TWO MOUSE ISOANTIGENS ON RED CELLS  AND TISSUES DETECTED SEROLOGICALLY.


PROLONGATION OF CANINE RENAL HOMOGRAFT  SURVIVAL BY ANTIMETABOLITES.


THE PRESENCE OF HUMORAL  FACTORS IN HOMOGRAFT REJECTION OF THE TRANSPLANTED HEART.


THE LEVELS OF FREE ASPARTIC ACID, GLYCINE, AND SERINE IN  TISSUES OF BONE MARROW CHIMERAS.


FETAL CIRCULATIONS IN THE PLACENTA OF DASYPUS NOVEMCINCTUS  LINN. AND THEIR SIGNIFICANCE IN TISSUE TRANSPLANTATION.


DEVELOPMENT OF HOMOTRANSPLANTATION ANTIGENS IN MOUSE HEMOPOIETIC TISSUES.


BLOOD PLATELETS AND TRANSPLANTATION ANTIGENS.


ONTOGENESIS OF IMMUNOLOGICAL COMPETENCE OF LYMPHOCYTES IN CHICKEN SKIN.


TRANSPLANTATION OF PERITONEAL FLUID CELLS.


MOUSE FETAL LIVER AND THYMUS: POTENTIAL SOURCES OF IMMUNOLOGICALLY  ACTIVE CELLS.


DIFFERENTIAL RADIOSENSITIVITY OF FIRST AND SECOND-SET RESPONSES TO  ALLOGENEIC AND XENOGENEIC SKIN GRAFTS IN LETHALLY IRRADIATED MICE.


IMMUNOLOGICAL COMPETENCE OF NEWBORN MICE.


SPECIFIC AND NON-SPECIFIC ASPECTS OF NEONATAL VACCINATION AGAINST  GRAFT-VERSUS-HOST REACTION.


NOTES ON THE PROBLEMS OF THE  TRANSPLANTATION OF KIDNEYS IN DOGS.


SUBLETHAL TOTAL  BODY IRRADIATION AND RENAL TRANSPLANTATION.


THE SERIAL PASSAGE OF A HUMAN ASTROCYTOMA IN EGGS.


BIBLIOGRAPHY ON CARTILAGE TRANSPLANTATION.


STUDIES ON PYRIODOXINE AND LIPID METABOLISM IN RAT.


GROWTH CURVES, HISTOLOGY AND VIRUS TITRES IN ROUS SARCOMAS. A COMPARISON BETWEEN PROGRESSIVELY GROWING AND REGRESSING TUMOURS.


STUDIES ON ODONTOGENIC CYST EPITHELIUM. 2. CLINICAL AND ROENTGENOLOGIC ASPECTS OF ODONTOGENIC KERATOCYSTS.


DILATED RENAL COLLECTING DUCTS IN A NEWBORN INFANT AS A PRECURSOR TO MEDULLARY SPONGE KIDNEY. REPORT OF A CASE.


INTRACEREBRAL, POSSIBLY MALIGNANT OSTEOCHONDROFIBROMA IN A CHILD.


THE MIXED GERM CELL TUMOURS WITH HORMONAL ACTIVITY.


THE ANTISTAPHYLOLYSIN TITRE IN CATTLE AFTER SUBCUTANEOUS AND INTRAMUSCULAR TREATMENT, RESPECTIVELY, WITH A COMBINED STAPHYLOCOCCAL VACCINE.


TECHNIQUE OF VOGES-PROSKAUER TEST.

TECHNIQUE OF VOGES-PROSKAUER TEST.


A SIMPLE METHOD TO PREPARE PARTICLES IN SUSPENSION FOR ELECTRON MICROSCOPY.


SUPPLEMENT TO THE KAUFFMANN-WHITE-SCHEME (VI).


THE EFFECT OF THALIDOMIDE ON THE GROWTH CURVE OF A RIBOFLAVIN DEPENDENT MICROBE.


SERODIFFERENTIATION BETWEEN TYPE 1 POLIOVIRUSES WITH ANTISERA PRODUCED IN RABBITS USING FOUR DIFFERENT IMMUNIZATION SCHEMES.


AUTOGENIC STATE AND AUTOGENIC SHIFT: PSYCHOPHYSIOLOGIC AND NEUROPHYSIOLOGIC ASPECTS.


RORSCHACH RESPONSES AND TREATMENT RESULTS UNDER DRUG AND GROUP PSYCHOTHERAPY.


THE QUEST FOR SURVIVAL. A TRAINING PROGRAM FOR FAMILY DIAGNOSIS AND TREATMENT.


GROUP AND INDIVIDUAL PSYCHOTHERAPY UNDER LSD.


RADIOLOGIC FINFINGS IN TEMPORAL LOBE  EPILEPSY OF NON-TUMORAL ORIGIN.


CEREBRAL PNEUMOGRAPHY WITH CONTINUOUS  CONTROL OF VENTRICULAR FLUID PRESSURE.


UREA AS AN AID IN ENCEPHALOGRAPHY.

UREA AS AN AID IN ENCEPHALOGRAPHY.


DEVELOPMENT OF VENTRICULAR DIVERTICULA FOLLOWING VENTRICULAR  PUNCTURE IN HYDROCEPHALIC INFANTS.


LUMBAR ENCEPHALOGRAPHY IN PONTINE AND INTRACEREBELLAR TUMORS.


INFLUENCE OF VENTRICULAR SIZE ON MORTALITY AND MORBIDITY FOLLOWING  VENTRICULOGRAPHY.


FURTHER OBSERVATIONS ON THE SUBARACHNOID CISTERNS IN SPACE-OCCUPYING LESIONS OF  THE POSTERIOR CRANIAL FOSSA.


THE SUBARACHNOID CISTERNS IN INTRACRANIAL HYPERTENSION.


ENCEPHALOGRAPHIC APPEARANCES IN SKULL INJURIES.


VENTRICULAR DILATATION MASKING THE PRESENCE OF CEREBRAL TUMOURS.


CINE-ENCEPHALOGRAPHIC STUDIES UNDER NORMAL AND  PATHOLOGICAL CONDITIONS.


SOFT TISSUE MASSES IMMEDIATELY BELOW THE FORAMEN MAGNUM.


EVALUATION OF LUMBAR RADICULOGRAPHY  ('MYELOGRAPHY') WITH WATER-SOLUBLE CONTRAST MEDIA.


CERVICAL DISCOGRAPHY.

CERVICAL DISCOGRAPHY.


MYELOGRAPHIC ASSESSMENT OF OCCULT FORMS OF SPINAL DYSRAPHISM.


MYELOGRAPHY IN A CASE OF THE OCCULT FORM OF SPINAL DYSRAPHISM.


MOBILITY OF THE THORACIC SPINAL CORD UNDER NORMAL CONDITIONS.


INTRAOSSEOUS EPIDURAL VENOGRAPHY IN THE DIAGNOSIS OF SURGICAL  DISEASES OF THE LUMBAR SPINE.


SACRAL CYSTS.

SACRAL CYSTS.


MENINGO- AND MYELOMENINGOCELE STUDIED BY GAS MYELOGRAPHY.


DIFFICULTY IN DIFFERENTIATING BETWEEN FOURTH VENTRICLE AND BRAIN STEM MASSES.


CEREBRAL TUBERCULOMA.

CEREBRAL TUBERCULOMA.


THE RADIOLOGIC ASPECTS OF CEREBRAL CYSTICERCOSIS.


POSITIVE CONTRAST VENTRICULOGRAPHY OF PINEAL REGION TUMOURS.


VARIATIONS IN CORPUS CALLOSUM, SEPTUM PELLUCIDUM AND  FORNIX, AND THEIR EFFECT ON THE ENCEPHALOGRAM AND CEREBRAL ANGIOGRAM.


COCCIDIOIDAL MENINGITIS--ROENTGEN AND PATHOLOGIC ANALYSES.


RADIOLOGICALLY CONTROLLED INJECTIONS THROUGH THE FORAMEN OVALE FOR RELIEF  OF TIC DOULOUREUX AND OF PARKINSONISM.


ROENTGENOLOGIC DIAGNOSIS OF CEREBRAL CYSTICERCOSIS.


SIZE OF THE TENTORIAL INCISURA RELATED TO CEREBRAL HERNIATION.


INFLUENCE OF CONTRAST MEDIA ON THE CENTRAL NERVOUS SYSTEM.


COMBINED PHLEBO-PNEUMOGRAM OF THE POSTERIOR CRANIAL FOSSA.


ANATOMIC CASTS MADE BY A CORROSION METHOD.


THE RECURRENT ARTERY OF HEUBNER AND THE ARTERIES OF THE CENTRAL GANGLIA.


APPLICATION OF THE ROENTGENOGRAPHIC  SUBTRACTION METHOD IN NEURORADIOLOGY.


'RIAF' --RADIO-IODINATED ANTI-FIBRINOGEN ENCEPHALOGRAPHY.


SCHISTOSOMIASIS CONTROL IN THEORY AND PRACTICE.


PLASMODIUM MALARIAE IN UGANDAN CHILDREN. I. PREVALENCE IN YOUNG CHILDREN IN RURAL COMMUNITIES.


PLASMODIUM MALARIAE IN UGANDAN CHILDREN. II. MALARIA PARASITES IN CHILDREN AT MULAGO HOSPITAL IN KAMPALA.


CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM PORTO VELHO, BRAZIL.


DRUG RESISTANCE IN PLASMODIUM FALCIPARUM FROM THAILAND.


THE SELECTIVE ABILITY OF STRAINS OF ENTAMOEBA HISTOLYTICA TO HEMOLYSE RED BLOOD CELLS.


INFLUENCE OF SOME STEROIDS IN THE EXPERIMENTAL PRODUCTION OF AMEBIC HEPATIC ABSCESS.


MORPHOLOGICAL STUDIES ON THE DEVELOPMENT OF THE TOXOPLASMA CYST.


SOME QUANTITATIVE ASPECTS OF DIAGNOSIS AND EPIDEMIOLOGY IN SCHISTOSOMIASIS MANSONI.


HOST-PARASITE RELATIONSHIPS IN ECHINOCOCCOSIS. IX. IN VITRO SURVIVAL OF HYDATID SCOLICES AND THE EFFECTS OF DRUGS UPON SCOLEX RESPIRATION.


THE ISOLATION AND CHARACTERIZATION OF TWO HOST ANTIGENS IN HYDATID FLUID OF ECHINOCOCCUS GRANULOSUS.


ANGIOSTRONGYLUS CANTONENSIS INFECTION IN RATS AND RHESUS MONKEYS, AND OBSERVATIONS ON THE SURVIVAL OF THE PARASITE IN VITRO.


THE EFFECTS OF TRICLOFENOL PIPERAZINE IN PATIENTS PARASITIZED BY HOOKWORMS, ASCARDIDS, OR TRICHURIDS.


PARASITISM IN CONGO PYGMIES.

PARASITISM IN CONGO PYGMIES.


PROBLEMS OF CHOLERA (EL TOR).

PROBLEMS OF CHOLERA (EL TOR).


HISTOPLASMOSIS IN THAILAND: REPORT OF TWO CASES DIAGNOSED BY BIOPSY AND CULTURE.


JUNGLE YELLOW FEVER AND ITS CONTROL IN GEMENA, BELGIAN CONGO.


ANTIGENIC VARIATION AMONG STRAINS OF WESTERN EQUINE ENCEPHALOMYELITIS VIRUS.


SEROLOGIC EVIDENCE OF GROUP A AND B ARTHROPOD-BORNE VIRUS ACTIVITY IN NEW YORK STATE.


THE BEHAVIOR OF MURRAY VALLEY ENCEPHALITIS VIRUS IN CULEX TRITAENIORHYNCHUS GILES AND CULEX PIPIENS QUINQUEFASCIATUS SAY.


SUSCEPTIBILITY OF WILD RODENTS TO EXPERIMENTAL INFECTION WITH COXIELLA BURNETII.


THE NOMENCLATURE OF ISOLATES OF VIRUS FROM TRACHOMA AND INCLUSION BLENNORRHEA.


LABORATORY STUDIES ON 4,6DIAMINO-1-(P-CHLOROPHENYL)-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE PAMOATE (CI-501) AS A  REPOSITORY ANTIMALARIAL DRUG.


THE ACTIVITY OF A REPOSITORY FORM OF 4,6-DIAMINO-1(P-CHLOROPHENYL)-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE AGAINST INFECTIONS WITH PLASMODIUM  CYNOMOLGI.


THE EFFECT OF A REPOSITORY  PREPARATION OF THE DIHYDROTRIAZINE METABOLITE OF CHLORGUANIDE, CI-501, AGAINST THE CHESSON  STRAIN OF PLASMODIUM VIVAX IN MAN.


STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT  PLASMODIUM FALCIPARUM FROM COLOMBIA, SOUTH AMERICA.


THERAPEUTIC TRIALS OF A DIHYDROXYNAPHTHALENE  (377C54) AGAINST PLASMODIUMFALCIPARUM AND PLASMODIUM VIVAX INFECTIONS IN HUMAN VOLUNTEERS.


THE NATURE OF PLASMODIUM GALLINACEUM HOST SPECIFICITY. I. APPARENT SITE  OF SPOROZOITE ARREST IN THE NON-SUSCEPTIBLE SPECIES.


TRYPANOSOMES OF SOUTH AMERICAN  MONKEYS AND MARMOSETS.


EFFECTS OF METRONIDAZOLE ON TRICHOMONAS VAGINALIS IN CULTURE AND IN AN  EXPERIMENTAL HOST.


IMMUNOELECTROPHORETIC ANALYSIS OF ADULTS AND LARVAE OF TRICHINELLA SPIRALIS.


NATURAL AND EXPERIMENTAL INFECTION OF BEDBUGS WITH WUCHERERIA BANCROFTI IN  BRITISH GUIANA.


AN EVALUATION OF THE BENTONITE FLOCCULATION AND INDIRECT  HEMAGGLUTINATION TESTS FOR THE DIAGNOSIS OF FILARIASIS.


CAUSE AND CONTROL OF FATAL, INFANTILE DIARRHEAL DISEASES.


STUDIES OF DIARRHEAL DISEASE IN CENTRAL  AMERICA. V. ENVIRONMENTAL FACTORS IN THE ORIGIN AND TRANSMISSION OF ACUTE DIARRHEAL DISEASE  IN FOUR GUATEMALAN VILLAGES.


SEROLOGICAL STUDIES ON  LEPTOSPIROSIS IN GUATEMALA.


RELATIONSHIPS AMONG ARTHROPOD-BORNE ANIMAL VIRUSES DETERMINED BY CROSS-CHALLENGE  TESTS.


USE OF AN  ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN.


PHYSIOLOGY AND PHARMACOLOGY IN DIABETES MELLITUS: GUIDING THE DIABETIC PATIENT THROUGH THE SURGICAL PERIOD.


PHYSIOLOGIC, PHARMACOLOGIC AND THERAPEUTIC CONSIDERATIONS IN SURGERY FOR HYPERTHYROIDISM.


PRESENT STATUS OF THE PROBLEM OF IATROGENIC ADRENAL CORTICAL INSUFFICIENCY.


PREOPERATIVE AND POSTOPERATIVE MANAGEMENT OF ADRENAL CORTICAL HYPERFUNCTION.


PHEOCHROMOCYTOMA: DIAGNOSIS AND ANESTHETIC AND SURGICAL MANAGEMENT.


DIAGNOSIS AND TREATMENT OF RENAL HYPERTENSION OF HUMORAL ORIGIN.


RENAL EFFECTS OF ANESTHESIA AND OPERATION MEDIATED BY ENDOCRINES.


HYPERPARATHYROIDISM AND HYPOPARATHYROIDISM: PREOPERATIVE AND POSTOPERATIVE CARE.


THE EFFECTS OF PREANESTHETIC MEDICATION, ANESTHESIA AND HYPOTHERMIA ON THE ENDOCRINE RESPONSE TO INJURY.


NEUROENDOCRINE AND OTHER EFFECTS ON CARBOHYDRATE  METABOLISM DURING ANESTHESIA.


EFFECTS OF ANESTHETICS ON THE RESPONSE OF THE MICROCIRCULATION TO CIRCULATING HUMORS.


PHARMACOLOGY OF RESERPINE AND ITS IMPLICATIONS FOR ANESTHESIA.


HORMONAL INFLUENCES ON IMMUNE MECHANISMS.


RECURRENT RESPIRATORY INFECTIONS COMPLICATING BRONCHIAL ASTHMA. A DOUBLE BLIND STUDY IN PROPHYLAXIS.


PHARMACOLOGICALLY ACTIVE BRAIN SUBSTANCES AND THEIR RELATION TO ENDOCRINE EFFECTS.


URINARY DETERMINATION OF 5-HYDROXY-INDOLEACETIC ACID, CATABOLITE OF SEROTONIN, IN NORMAL SUBJECTS AND RESPIRATORY ALLERGIC PATIENTS.


RAGWEED POLLINOSIS. THE TREATMENT OF POLLINOSIS BY MEANS OF EMULSIFIED EXTRACTS XXVII. A STUDY OF 1809 PATIENTS STUDIED FOR THE 1962 RAGWEED POLLEN SEASON.


CORTICOSTEROID CHOICE IN ALLERGY.

CORTICOSTEROID CHOICE IN ALLERGY.


A NEW ENZYME AS ADJUNCTIVE THERAPY IN BRONCHIAL DISORDERS.


ENDOCRINE CONSEQUENCES OF HYPOPHYSECTOMY.


ETIOLOGIC FACTORS IN ALLERGIC DISEASES: MOLDS.


A MODIFIED TONGUE BLADE FOR ADENOTONSILLECTOMY.


NEURONS IN THE TISSUE CULTURE.

NEURONS IN THE TISSUE CULTURE.


SUBARACHNOID BLOCK WITH PHENOL-GLYCERINE FOR THE RELIEF OF INTRACTABLE PAIN.


MULTIPLE AUTOCLAVING OF COMMERCIAL LOCAL ANESTHETIC SOLUTIONS CONTAINING DILUTE EPINEPHRINE.


THE EFFECT OF MAINSTREAM NEBULIZATION ON OXYGENATION WITH  IPPB.


THE BECK-RAND EXTERNAL CARDIAC COMPRESSION MACHINE.


AN IMPROVED ECG LUER-LOK ADAPTOR.

AN IMPROVED ECG LUER-LOK ADAPTOR.


LIGHT-AND ELECTRON MICROSCOPE STUDIES ON THE ANTERIOR  PITUITARY (UBERGANGSTEIL OF STENDELL) OF THE CARP (CYPRINUS CARPIO LINN'E).


PERENNIALLY YOUNG.

PERENNIALLY YOUNG.


MECHANISM OF DEHYDRATION FOLLOWING ALCOHOL INGESTION.


MASSIVE PULMONARY EMBOLISM.

MASSIVE PULMONARY EMBOLISM.


DEATH RESULTING FROM PNEUMOCYSTIS PNEUMONIA IN AN ADULT.


BEDSIDE PROSPECTING WITH A GEIGER COUNTER. AN UNUSUAL CASE OF MALBSORPTION.


PHOTOSENSITIVITY, NAIL DISCOLORATION, AND ONYCHOLYSIS. SIDE EFFECTS OF TETRACYCLINE THERAPY.


ANAPHYLACTIC REACTION TO DEXTRAN. A CASE REPORT.


FATAL ANAPHYLACTIC REACTION TO SULFOBROMOPHTHALEIN.


HEPATIC HEMANGIOENDOTHELIOSARCOMA. REPORT OF A CASE DUE TO THORIUM.


VIRAL HEPATITIS ASSOCIATED WITH ENTERITIS GRAVIS.


IDIOPATHIC HEMOCHROMATOSIS. GENETIC OR ACQUIRED?


PORTAL HYPERTENSION SECONDARY TO PANCREATIC PSEUDOCYSTS.


CARDIAC FINDINGS IN 73 PATIENTS WITH MUSCULAR DYSTROPHY.


WHIPPLE'S DISEASE WITH ASSOCIATED SPLENOMEGALY AND PANCYTOPENIA.


GOITROUS MYXEDEMA DUE TO IODIDE TRAPPING DEFECT.


HYPOSTHENURIA IN SICKLE CELL STATES.

HYPOSTHENURIA IN SICKLE CELL STATES.


ANGINA PECTORIS PRECEDING INITIAL MYOCARDIAL INFARCTION. A CLINICOPATHOLOGIC STUDY.


PERICARDITIS AND AURICULAR FIBRILLATION. OCCURRENCE IN FAMILIAL MEDITERRANEAN FEVER.


STAPHYLOCOCCAL MENINGITIS COMPLICATED BY  SUBARACHNOID BLOCK. REPORT OF A CASE SUCCESSFULLY TREATED BY INTRATHECAL STREPTOKINASE AND STREPTODORNASE.


DEXTROVERSION OF THE HEART WITH RHEUMATIC MITRAL STENOSIS. A CASE REPORT.


COCCIDIOIDOMYCOSIS FROM FOMITES. REPORT OF A CASE AND REVIEW OF THE LITERATURE.


HEART DISEASE. RESEARCH BEYOND THE LABORATORY.


DIAGNOSIS OF RENAL ARTERIAL LESIONS.

DIAGNOSIS OF RENAL ARTERIAL LESIONS.


FREE NUCLEOTIDES OF THE NERVOUS TISSUE. III. FREE NUCLEOTIDES IN THE BRAIN AND LIVER OF GUINEA PIGS.


EFFICIENCY OF MENTAL HOSPITALS.

EFFICIENCY OF MENTAL HOSPITALS.


DETECTION OF LOW INTENSITY EPIDEMICITY: APPLICATION TO CLEFT LIP AND PALATE.


SOURCES OF SEASONAL VARIATION IN RECORDED LENGTH OF GESTATION.


THE PART PLAYED BY ADENOIDECTOMY IN THE COMBINED OPERATION OF TONSILLECTOMY WITH ADENOIDECTOMY. SECOND PART OF A CONTROLLED STUDY IN CHILDREN.


MOTHERS AT WORK: A STUDY OF THE HEALTH OF PRIMARY SCHOOL CHILDREN CARRIED OUT FOR THE KENT PAEDIATRIC AND CHILD HEALTH SOCIETY.


ALCOHOL CONSUMPTION AND SMOKING HABITS IN MALE PATIENTS WITH PULMONARY TUBERCULOSIS.


RADIOLOGY IN THE NATIONAL HEALTH SERVICE.


BONE CHANGES IN ORBITAL NEUROFIBROMATOSIS.


WILDERVANCK'S SYNDROME. KLIPPEL-FEIL'S SYNDROME ASSOCIATED WITH DEAFNESS AND RETRACTION OF THE EYEBALL.


UNILATERAL ATRESIA OF THE INTERNAL AUDITORY MEATUS, CONFIRMED BY RADIOGRAPHY.


MULTIPLE PARAVERTEBRAL LUMBAR MENINGOCELE.


THE RADIOLOGICAL DIAGNOSIS OF GASTRIC ATROPHY.


A RADIOLOGICAL STUDY OF THE EFFECT OF THE DEEP FASCIA ON THE COMMUNICATING VEINS OF THE LEG.


GEOMETRIC ENLARGEMENT IN ROENTGEN TELEVISION.


STUDIES IN THE DESIGN AND APPLICATIONS OF A CLINICAL LOW BACKGROUND COUNTING ROOM.


AN ADAPTABLE WATER PHANTOM, DESIGNED FOR THE MEASUREMENT OF MOVING-BEAM DOSE DISTRIBUTIONS FOR INDIVIDUAL PATIENTS.


A MOTOR DRIVEN X-RAY ROLL FILM DISPLAY UNIT.


FURTHER PROBLEMS OF RENAL TRANSPLANTATION.


PANTOTHENIC ACID AND ILEUS.

PANTOTHENIC ACID AND ILEUS.


SUBACUTE THYROIDITIS OF DE QUERVAIN.

SUBACUTE THYROIDITIS OF DE QUERVAIN.


TREATMENT OF HYDROCEPHALUS.

TREATMENT OF HYDROCEPHALUS.


THE ESMARCH BANDAGE.

THE ESMARCH BANDAGE.


GLUCOSE TOLERANCE AND GLYCOSURIA IN THE GENERAL POPULATION: REPORT OF A WORKING PARTY  APPOINTED BY THE COLLEGE OF GENERAL PRACTITIONERS.


"IDIOPATHIC" PES CAVUS: AN INVESTIGATION INTO ITS AETIOLOGY.


DAPSONE-INDUCED HAEMOLYSIS.

DAPSONE-INDUCED HAEMOLYSIS.


DESENSITIZATION FOR DAPSONE DERMATITIS.

DESENSITIZATION FOR DAPSONE DERMATITIS.


A STUDY OF HUMAN COLONIC MUSCLE IN VITRO.


PRIMARY PYOGENIC OSTEOMYELITIS OF THE RIBS.


BIOLOGICAL PRODUCTS. II. COMBINED VACCINES.


THE GOOD GENERAL PRACTITIONER AND THE NATIONAL HEALTH SERVICE.


AN OBSTETRICAL TOWEL CLIP.

AN OBSTETRICAL TOWEL CLIP.


PREVENTION OF CARCINOMA OF THE CERVIX.

PREVENTION OF CARCINOMA OF THE CERVIX.


ABORTION AND THE PSYCHIATRIST.

ABORTION AND THE PSYCHIATRIST.


IRON INTOXICATION FROM CONTROLLED-RELEASE TABLETS.


THE MANAGEMENT OF PERFORATION IN STRANGULATED HERNIA.


THYROTOXICOSIS IN SOUTHERN RHODESIA.

THYROTOXICOSIS IN SOUTHERN RHODESIA.


ANALYSIS OF AMNIOTIC FLUID IN THE MANAGEMENT OF THE RHESUS SENSITISED PREGNANCY.


ACUTE NON-SPECIFIC ARTHRITIS IN THE AFRICAN.


PHOTOSENSITIVITY AND PHOTO-ONYCHOLYSIS DUE TO DIMETHYLCHLORTETRACYCLINE.


MALVERN THE SURGEON: AN APPRECIATION ON HIS EIGHTIETH BIRTHDAY (GODFREY MARTIN HUGGINS).


THE OPENING OF LITETA LEPROSARIUM.

THE OPENING OF LITETA LEPROSARIUM.


"..BY THE SAME DOOR AS IN I WENT".

"..BY THE SAME DOOR AS IN I WENT".


EXTRACT ON HEALTH FROM "THE BREAK UP--EFFECTS AND CONSEQUENCES ON THE TWO RHODESIAS".


MPILO HOSPITAL STAFF CLINICAL MEETING, MAY AND JUNE 1963.


FURTHER STUDIES OF THE INFLUENCE OF THE POTATO EXTRACT DIALYSATE ON GROWTH AND SPORE FORMATION ON THE STRAIN THETA B. PUMILUS AND THE PRODUCTION OF THE ANTIBIOTIC TETAINE.


A GENERATION OF HYPERTENSION.

A GENERATION OF HYPERTENSION.


ALLERGY, HISTAMINE, AND THE BASOPHIL.

ALLERGY, HISTAMINE, AND THE BASOPHIL.


PITFALLS IN TETRACYCLINE THERAPY.

PITFALLS IN TETRACYCLINE THERAPY.


BIOLOGICALLY ACTIVE, WATER-SOLUBLE DERIVATIVES OF NYSTATIN-CHEMICAL STUDIES.


REVOLUTION IN BIOLOGY.

REVOLUTION IN BIOLOGY.


DANGERS IN POLYPHARMACY.

DANGERS IN POLYPHARMACY.


THE CATION-RETAINING ACTION OF SYMPATHOMIMETIC SUBSTANCES IN THE RAT.


BIOLOGICALLY ACTIVE, WATER-SOLUBLE DERIVATIVES OF NYSTATIN-MICROBIOLOGICAL STUDIES.


MEDICONATROPHOBIA.

MEDICONATROPHOBIA.


CLINICAL PROBLEMS IN PASSENGER FLYING.

CLINICAL PROBLEMS IN PASSENGER FLYING.


THE ACTION OF SUBSTITUTED 2-FURANACROLEIN PHENYLHYDRAZONES ON PATHOGENIC FUNGI.


CLINICO-PHYSIOLOGIC ASPECTS OF PASSENGER FLIGHT.


GENERAL MEDICAL PROBLEMS IN PASSENGER FLYING.


CARDIOPULMONARY CONDITIONS: THEIR ASSESSMENT FOR CRITERIA FOR PASSENGER  FLYING.


THE SEROTONIN STORY. HOW SCIENCE GROWS.

THE SEROTONIN STORY. HOW SCIENCE GROWS.


DELAYS IN CONCEPTION: A DISCREPANCY RE-EXAMINED.


EXCESS AND UNWANTED FERTILITY.

EXCESS AND UNWANTED FERTILITY.


ANALYSIS OF BIRTH INTERVALS OF A SET OF INDIAN WOMEN.


POPULATION DIFFERENCES IN RED AND GREEN COLOR VISION DEFICIENCY: A REVIEW, AND A QUERY ON SELECTION RELAXATION.


"COLORBLINDNESS" AND RELAXED SELECTION.

"COLORBLINDNESS" AND RELAXED SELECTION.


COMPARATIVE TESTING OF A NEW PHOTOGRAPHIC MATERIAL FOR RAPID REGISTRATION OF IMMUNOPRECIPITATES.


THE DEMONSTRATION OF IDENTICAL IMMUNOLOGICAL SPECIFICITY OF PRECIPITATING AND NON-PRECIPITATING ANTIBODIES.


SECONDARY PRECIPITATION IN IMMUNODIFFUSION TESTS.


SKIN SENSITIVITY TO HISTAMINE IN ECZEMA AND PSORIASIS.


AN EVALUATION OF THE EFFICIENCY OF ANTI-HISTAMINES FOR THE TREATMENT OF HAY-FEVER.


ATOPIC REAGINS TO PENICILLIN, POLLENS AND SEEDS: THERMOLABILITY, TITER AND PERSISTENCE IN THE SKIN OF PASSIVELY SENSITIZED MACAQUE MONKEYS.


ILOLATION AND CHARACTERIZATION OF LABILOMYCIN, A NEW  ANTIBIOTIC.


TAXONOMICAL STUDIES ON A STREPTOMYCES STRAIN PRODUCING  LABILOMYCIN.


ANTIPROTOZOAL ANTIBIOTICS. I.

ANTIPROTOZOAL ANTIBIOTICS. I.


ANTIPROTOZOAL ANTIBIOTICS. II.  ISOLATION AND CHARACTERIZATION OF TRYPACIDIN, A NEW ANTIBIOTIC, ACTIVE AGAINST  TRYPANOSOMA CRUZI AND TOXOPLASMA GONDII.


ANTIPROTOZOAL  ANTIBIOTICS. III. PRELIMINARY REPORT ON THE EFFECT OF TRYPACIDIN ON EXPERIMENTAL  TOXOPLASMOSIS.


MECHANISM OF ACTION OF ANGUSTMYCINS, NUCLEOSIDE ANTIBIOTICS.


PROTOMYCIN, A NEW ANTIBIOTIC OF CYCLOHEXIMIDE GROUP. III. DEGRADATION PRODUCTS.


INHIBITION OF RESISTANT   DYSENTERY BACILLI BY PHLEOMYCIN.


SYNTHESIS OF DEOXYKANAMYCIN.

SYNTHESIS OF DEOXYKANAMYCIN.


L-GAMMA-FORMYL-N-METHYL-NORVALINE, A NEW AMINO ACID IN ILAMYCIN.


ULTRAVIOLET AND PHASE  MICROSCOPY OF SPORULATING SACCHAROMYCES. Miller, Glendon R. (Southern Illinois University, Carbondale), Dan O. McClary, and Wilbert D. Bowers, Jr. Ultraviolet and phase microscopy of sporulating Saccharomyces. J. Bacteriol. 85:725-731. 1963.-During active growth, the cytoplasm of yeast cells is densely absorbent to ultraviolet light at 260 mmu, whereas the nucleus is only faintly so, and the vacuole is nonabsorbent. After 24 hr on presporulation medium (about the age of transfer to acetate sporulation medium), the cells manifest many characteristics of starvation. The cytoplasm is weakly absorbent to ultraviolet light except for a dense zone immediately surrounding the vacuole and one or two groups of highly refractile granules clustered on one or both sides of the juncture of the nucleus and the vacuole. After several hours on the acetate sporulation medium, the cells undergo a progressive vacuolation until four or more large vacuoles appear, separated by granular cytoplasm. The nucleus is obscured to ultraviolet light during the vacuolation stage, at which time previous studies have shown its division to occur, and remains so during the rest of the cycle. Photographs of densely granulated cells, at various wavelengths of ultraviolet and visible light, indicated several different types of granules with respect to their absorption spectra. With continued development of the ascus, the granules increase in number until they fill the entire cell and obscure the vacuoles, after which they condense into a compact mass, leaving much of the cell empty. Spores emerge from the granular mass as separate, ultraviolet-absorbent regions without distinguishable cell walls, which seem to be the last structures formed. The rudimentary spores contain a central cluster of dense granules and are separated within the ascus by optically dense, granular partitions which diminish as spore walls are laid down. With the maturing of the ascus, the granules and epiplasm disappear, and the ascus wall is drawn tightly around the more or less homogeneously absorbent spores.


CHARACTERISTICS OF A STRAIN OF STAPHYLOCOCCUS AUREUS GROWN IN  VIVO AND IN VITRO. Beining, Paul R. (The Catholic University of America, Washington, D.C.) and E. R. Kennedy. Characteristics of a strain of Staphylococcus aureus grown in vivo and in vitro. J. Bacteriol. 85:732-741. 1963.-A comparative survey was conducted on the characteristics of a strain of Staphylococcus aureus after it had been grown in vitro (VSB) and after it had been collected from the peritoneal exudate of an infected guinea pig (GSB). Both VSB and GSB strains gave the same results when studied in an extensive series of tests, including bound and soluble coagulases, bacteriophage type, antibiotic-sensitivity pattern, the usual fermentation reactions, deoxyribonucleic acid base composition, and qualitative tests for hemolysins, deoxyribonuclease, ribonuclease, staphylokinase, staphyloprotease, lipase, and phosphatase. The in vivo strain differed significantly from the in vitro strain in respiratory rate, agar gel diffusion studies, agglutinability in tube tests, virulence tests in rabbits and mice, growth on tellurite-glycine agar, susceptibility to human gamma-globulin in agar, and in the quantitative production of deoxyribonuclease, alpha-hemolysin, leucocidin, and hyaluronidase.


PHENOTYPIC, GENOTYPIC, AND CHEMICAL CHANGES  IN STARVING POPULATIONS OF AEROBACTER AEROGENES. Harrison, Arthur P., Jr. (Vanderbilt University, Nashville, Tenn.) and Felix R. Lawrence. Phenotypic, genotypic, and chemical changes in starving populations of Aerobacter aerogenes. J. Bacteriol. 85:742-750. 1963.-Cells harvested from postlogarithmic (maximal stationary phase) Aerobacter aerogenes cultures and starved in dilute sodium phosphate at 40 C remained viable for many hours. On the other hand, most cells from logarithmic-phase cultures succumbed, although a relatively small number remained viable. This viable segment of the original population thus responded like cells from postlog-phase cultures and, in fact, had properties in common with them. The residual segment was comprised of cells of two kinds. The first were mutants; when cultivated, harvested during log-phase growth, and again starved, they were resistant. The second were wild-type; they responded exactly as before. During starvation, the mutant is at an advantage because it has the ability to convert from susceptible log-phase physiology to resistant postlog-phase physiology more rapidly than can wild-type. The mutant differs from wild-type in yet other ways. It is smaller in size, slower in growth rate, lower in ribonucleic acid (RNA)-deoxyribonucleic acid ratio, greater in light-scattering ability, and, during the first 4 hr of starvation, it loses a higher proportion of its RNA. Selection of mutants of low growth rate between periods of active clonal growth indicates that evolutionary advantage may not necessarily be with the fast-growing members of the clone.


LETHALITY OF STREPTOMYCIN FOR ALKALINE PHOSPHATASE CONSTITUTIVE  ESCHERICHIA COLI. Rosenkranz, Herbert S. (Columbia University, New York, N.Y.) and Howard S. Carr. Lethality of streptomycin for alkaline phosphatase constitutive Escherichia coli. J. Bacteriol. 85:751-753. 1963.-An alkaline phosphatase constitutive strain of Escherichia coli was more sensitive to streptomycin in a phosphorus-rich medium than was the wild parent strain. In a low-phosphorus medium, the efficiency of killing by streptomycin was nearly the same for both strains. The greater sensitivity displayed by the alkaline phosphatase constitutive strain in the phosphorus-rich medium was ascribed to the absence of internal inorganic phosphates in these bacteria. It has been shown that such anions interfere in the reaction of the antibiotic with deoxyribonucleic acid.


REDUCTION OF SELENITE BY INTACT YEAST CELLS AND CELL-FREE  PREPARATIONS. Falcone, Giuseppe (Rutgers, The State University, New Brunswick, N.J.), and Walter J. Nickerson. Reduction of selenite by intact yeast cells and cell-free preparations. J. Bacteriol. 85:754-762. 1963.-Nonproliferating cell suspensions of Candida albicans rapidly reduced selenite to red, metallic selenium in the absence of added substrate. Cell suspensions reduced selenite optimally at pH 4.2. No added metabolite was found to be stimulatory; reduction was inhibited by methionine and formate as well as by fluoride, dinitrophenol, and certain sulfhydryl poisons. Cell-free preparations capable of reducing selenite were obtained from C. albicans and from baker's yeast disintegrated in a Hughes press. The enzymatic system had optimal activity at pH 7 with 10(-2)m selenite. Activity of the system was lost on dialysis but was restored upon the addition of dialyzable substances or of boiled, undialyzed extract.


ENZYMATIC REDUCTION OF SELENITE.

ENZYMATIC REDUCTION OF SELENITE. Nickerson, Walter J. (Rutgers, The State University, New Brunswick, N.J.) and Giuseppe Falcone. Enzymatic reduction of selenite. J. Bacteriol. 85:763-771.-1963. Extraction of boiled yeast extract with n-hexane removed its ability to restore selenite-reducing capacity in dialyzed enzyme preparations obtained from baker's yeast or from Candida albicans. Menadione or thiodione substituted for the quinone(s) extracted by n-hexane. Active components of the water-soluble, dialyzable fraction of yeast extract included: glucose-6-phosphate, triphosphopyridine nucleotide, and glutathione. Selenite appears to be bound to protein through vicinal thiol groups, and to be released therefrom as metallic selenium after accepting four electrons.


NATURE OF THE LIPIDS OF SOME LACTIC ACID BACTERIA. Ikawa, Miyoshi (University of California, Berkeley). Nature of the lipids of some lactic acid bacteria. J. Bacteriol. 85:772-781. 1963.-Lactobacillus casei, L. plantarum, Leuconostoc mesenteroides, Pediococcus cerevisiae, and Streptococcus faecalis were grown on a lipid-free medium, and the amounts of acetone-soluble lipids, acetone-insoluble phospholipids, and unextracted or bound lipid in the cells were estimated. Neutral glycerides appeared to be absent, or present only in traces, in L. casei and S. faecalis. L. plantarum, L. mesenteroides, and P. cerevisiae, in addition to containing glycerides, appeared to contain glycolipids of glucose and galactose. Glycerol was present in the phospholipid fraction of all the organisms, and, in addition, galactose was present in L. mesenteroides. Paper chromatography of hydrolysates of the phospholipid fractions showed the absence of the usual phospholipid nitrogen bases, serine, ethanolamine, and choline, in these organisms. Microbiological assays of lyophilized unextracted cells for myo-inositol and choline also showed that lipids containing these components occurred in very small amounts at most. The principal ninhydrin-reacting substance in the phospholipid fraction of L. casei, L. plantarum, P. cerevisiae, and S. faecalis was lysine, which seemed to be exclusively of the l configuration. The principal ninhydrin-reacting substance in the L. mesenteroides phospholipid fraction was d-alanine. These amino acids appeared to be bound in components of the phospholipid fraction and not free.


EFFECT OF ANAEROBIC GROWTH ON NITRATE REDUCTION BY  STAPHYLOCOCCUS EPIDERMIDIS. Jacobs, N. J. (American Meat Institute Foundation, Chicago, Ill.), J. Johantges, and R. H. Deibel. Effect of anaerobic growth on nitrate reduction by Staphylococcus epidermidis. J. Bacteriol. 85:782-787. 1963.-In anaerobic cultures, a strain of Staphylococcus epidermidis failed to reduce nitrate, although nitrate was reduced in stationary cultures grown in the presence of air. Resting suspensions of cells grown in air reduced nitrate. Although suspensions of cells grown anaerobically did not reduce nitrate, the nitrate reductase enzyme was shown to be present. When the artificial electron carrier, benzyl viologen, was added to suspensions of cells grown anaerobically, nitrate was reduced, indicating that an electron carrier required for nitrate reduction was missing. The addition of hemin to the growth medium enabled anaerobic cultures to reduce nitrate.


EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. VI.  HIGH-FREQUENCY RESISTANCE TRANSFER SYSTEM IN ESCHERICHIA COLI. Watanabe, Tsutomu (Keio University, Tokyo, Japan). Episome-mediated transfer of drug resistance in Enterobacteriaceae. VI. High-frequency resistance transfer system in Escherichia coli. J. Bacteriol. 85:788-794. 1963.-R-factors (transmissible drug-resistance factors composed of the resistance-transfer factor and markers of resistance to sulfonamide, streptomycin, chloramphenicol, and tetracycline) gave rise to a high-frequency transfer system in Escherichia coli K-12 F(-), F(+), and Hfr strains that was similar to the high-frequency colicinogeny transfer system (HFCT) found by Stocker and Ozeki in Salmonella typhimurium with colicinogenic factor I. The procedure for obtaining a high-frequency transfer system of R-factors was identical to that for HFCT. The majority of cells of the high-frequency resistance transfer system were composed of cells which had just received R-factors by conjugation. These cells could act as highly competent donor cells for further transfer of the R-factors by conjugation. The frequencies of transfer of R-factors were as high as 1.5 to 7.5 per resistant donor cell introduced into mixed incubation with drug-sensitive recipient cells for 1 hr at 37 C, whereas the usual donor cells could transfer the R-factors at frequencies of, at most, 1:30 under similar conditions of mixed cultivation. It was also found that the aerobic conditions for growth of donor cells rather reduced the frequencies of transfer of R-factors in the usual systems. Possible mechanisms of the high-frequency resistance transfer system are discussed.


EFFECT OF DIHYDROSTREPTOMYCIN ON TETRAZOLIUM DYE REDUCTION IN  ESCHERICHIA COLI. Bragg, P. D. (University of British Columbia, Vancouver, British Columbia, Canada) and W. J. Polglase. Effect of dihydrostreptomycin on tetrazolium dye reduction in Escherichia coli. J. Bacteriol. 85:795-800. 1963.-Sonic-disrupted extracts of Escherichia coli, grown without added antibiotic (sensitive and resistant), contained (in supernatant of fraction centrifuged at 100,000 x g) a dihydrostreptomycin-inhibitable, succinate-triphenyltetrazolium chloride (TTC) reductase activity. The succinate-TTC reductase activities of extracts of E. coli grown in the presence of dihydrostreptomycin (resistant and dependent) were relatively low and were not inhibited by the antibiotic. At a moderate magnesium concentration, the degree of inhibition by dihydrostreptomycin of succinate-TTC reductase activity was sufficiently marked to indicate an important site of action of the antibiotic. Magnesium, putrescine, and spermidine antagonized the action of dihydrostreptomycin in the succinate-TTC reductase system.


SMALL-CELL SEGREGANTS FROM A POSSIBLY HOMOZYGOUS DIPLOID STRAIN OF  ESCHERICHIA COLI. Ogg, James E. (Colorado State University, Fort Collins) and Ronald D. Humphrey. Small-cell segregants from a possibly homozygous diploid strain of Escherichia coli. J. Bacteriol. 85:801-807. 1963.-Evidence was presented to show that a homozygous possibly diploid strain of Escherichia coli, when grown in a chemically defined medium under the conditions described in this report, will yield small-cell segregants that have haploid characteristics. The segregants have one-half as much deoxyribonucleic acid per cell as the diploid, give exponential survival curves when exposed to X rays, and have fermentative characteristics similar to the original haploid parent strain of the homozygous diploid strain. No detectable changes in surface antigens were associated with the segregation phenomenon. The haploidlike segregants can be converted to the diploid radiation-resistant state by growing them in the presence of camphor vapors.


ISOLATION, ENUMERATION, AND CHARACTERISTICS OF PROTEOLYTIC  RUMINAL BACTERIA. Fulghum, Robert S. (Virginia Polytechnic Institute, Blacksburg) and W. E. C. Moore. Isolation, enumeration, and characteristics of proteolytic ruminal bacteria. J. Bacteriol. 85:808-815. 1963.-Colony counts of proteolytic ruminal bacteria in the order of 10(9) organisms per g of whole rumen contents, and total colony counts in the order of 2 to 3 x 10(9) organisms per g, were obtained from rumen contents of cattle fed a maintenance ration of hay and grain. The proteolytic counts averaged 38% of the total counts. An anaerobic, differential medium characterizing proteolytic colonies by clear zones in an opaque skim-milk suspension was utilized. Proteolytic isolates were assigned to the following taxa: Butyrivibrio sp., Succinivibrio sp., Selenomonas ruminantium var. lactilytica, Borrelia sp., Bacteroides sp., and selenomonadlike organisms similar to the B-385 group of Bryant.


COMPARISON OF STRAINS OF SPOROTRICHUM SCHENCKII ISOLATED FROM NATURE. Howard, Dexter H. (University of California, Los Angeles) and G. F. Orr. Comparison of strains of Sporotrichum schenckii isolated from nature. J. Bacteriol. 85:816-821. 1963.-Several strains of fungi, tentatively considered to be members of the genus Sporotrichum, have been isolated from soil and from other sources in nature. The striking morphological similarity of these isolates to strains of S. schenckii led to a comparative study of their biological properties. Nine strains of Sporotrichum from nature were compared with twelve strains of S. schenckii isolated from cases of clinical sporotrichosis. The nine saprophytic isolates were indistinguishable microscopically and macroscopically from strains of pathogenic S. schenckii when cultures were prepared on a variety of media incubated at 28 C. Only two of the nine saprophytic isolates were able to grow at 37 C. These two strains partially converted, at this temperature, to a yeast-cell phase of growth. The blastospores comprising this phase of growth were similar to those produced by S. schenckii under the same circumstances. Six of the nine saprophytes were essentially avirulent for mice. The remaining three strains had a very limited capacity to produce disease in experimental animals. The isolates are currently regarded as variants of S. schenckii.


NUCLEOTIDE COMPOSITION OF RIBONUCLEIC ACID FROM NEUROSPORA CRASSA. Henney, H. (The University of Texas, Austin) and R. Storck. Nucleotide composition of ribonucleic acid from Neurospora crassa. J. Bacteriol. 85:822-826. 1963.-The nucleotide composition of total, ribosomal, and soluble ribonucleic acid (RNA) from the conidia and the hyphae of Neurospora crassa was determined. The corresponding RNA classes from the two morphological types had the same base ratio. Total, ribosomal, and soluble RNA from hyphae contained, respectively, 51.0, 50.2, and 61.6% guanylic acid (G) plus cytidylic acid (C), and from conidia, 50.6, 49.9, and 62.1%. The proportion of nucleotides in ribosomal RNA was in close agreement with that reported for ribosomal RNA from other organisms. Soluble RNA contained 2.8% pseudouridylic acid, 36.0% C, and 25.5% G, and differed from soluble RNA from other sources in its high C content. Centrifugation of purified RNA from conidia and hyphae, through a linear sucrose-density gradient, yielded identical sedimentation profiles.


FOOD-POISONING POTENTIAL OF THE ENTEROCOCCI. Deibel, R. H. (American Meat Institute Foundation, Chicago, Ill.), and J. H. Silliker. Food-poisoning potential of the enterococci. J. Bacteriol. 85:827-832. 1963.-A total of 23 enterococcus strains were fed to two and sometimes three human volunteers in an effort to elicit food-poisoning symptoms. Each culture was consumed after it was grown in whole sterile milk or on the surface of commercially sterile ham slices. Six strains of Streptococcus faecalis var. liquefaciens were consumed after complete liquefaction of gelatin. In addition, strains of S. faecalis were consumed after having been grown in media which altered the energy metabolism (arginine, gluconate, malate, and pyruvate). In no instance were any of the above conditions of growth conducive to the production of food-poisoning symptoms in the volunteers. Moreover, no evidence was found to indicate that either the age of the culture or the disruption of the cell was a factor in the production or release of a toxic principle. It would appear that until the environmental conditions (if any) for food poisoning are defined the evidence obtained suggests that the association of enterococci and food poisoning is questionable.


EFFECTS OF THE ANTIFUNGAL PEPTIDE RO 2-7758 ON MORPHOLOGY OF MUCOR CORYMBIFERA. Gale, Glen R. (Veterans Administration Hospital and Duke University Medical Center, Durham, N.C.). Effects of the antifungal peptide Ro 2-7758 on morphology of Mucor corymbifera. J. Bacteriol. 85:833-837. 1963.-Hyphae of Mucor corymbifera grown in the presence of the antifungal peptide, Ro 2-7758, were examined in an electron microscope. The predominant change, compared with control hyphae, was a marked thickening of the cell wall, with apparent maintenance of normal structure. Cell walls of control hyphae were from 0.03 to 0.11 mu in thickness; drug-treated walls varied from 0.22 to over 0.75 mu in thickness. The possible sites and mechanisms of action, as well as the significance of a thickened cell wall in antibiosis, are discussed.