ELECTRON MICROSCOPIC RADIOAUTOGRAPHY OF HELA CELLS INFECTED WITH ADENOVIRUS. Harford, Carl G. (Washington University, St. Louis, Mo.), and Alice Hamlin. Electron microscopic radioautography of HeLa cells infected with adenovirus. J. Bacteriol. 89:1540-1547. 1965.-Because intracellular particles of adenovirus are not seen by light microscopy, radioautography with tritiated thymidine was carried out with an electron microscope. Reacted grains were present over many nuclei containing viral aggregates, but only 16% of these grains were over the aggregates. Control observations with tritium-labeled bacteria indicated that this low incidence of labeling of viral aggregates could not be attributed to errors of the method. We think that deoxyribonucleic acid (DNA) labeled with tritiated thymidine in these experiments was mainly the excess viral DNA that is known to accumulate in adenovirus-infected cells. We did not exclude the possibility that some cellular DNA was labeled.


REOVIRUSES. II. STRUCTURE AND COMPOSITION OF THE VIRION. Mayor, Heather D. (Baylor University College of Medicine, Houston, Tex.), Richard M. Jamison, Liane E. Jordan, and M. Van Mitchell. Reoviruses. II. Structure and composition of the virion. J. Bacteriol. 89:1548-1556. 1965.-Reovirus type 1 has been grown in green monkey kidney cells and harvested 24 hr after infection ("early" virus) and 96 hr after infection ("late" virus). A number of biological parameters have been determined on purified preparations of both "early" and "late" harvests of reovirus. There were no significant differences in values obtained for the molecular weight, RNA content, and buoyant density of virions prepared from early or late harvests. The size of the capsids and their morphology were also identical. Late harvests of reovirus were particularly rich in empty viral capsids (density, 1.28 in cesium chloride), and a significant number of empty inner capsid shells were routinely found. These shells could be prepared readily by controlled digestion of complete virus particles with trypsin. The inner shell appears to be composed of subunits packed with icosahedral symmetry to form a 45-mmu foundation on which the outer 92-subunit capsid is assembled. The inner shell is somewhat reminiscent in size and morphology of the capsid of papovaviruses. The fact that it can exist as a discrete entity has prompted us to propose some modifications to the current models for the reovirus capsid.


FINE STRUCTURE OF THE COAT AND NUCLEOID MATERIAL OF FOWLPOX VIRUS. Hyde, James M. (University of Mississippi School of Medicine, Jackson), Lanelle G. Gafford, and Charles C. Randall. Fine structure of the coat and nucleoid material of fowlpox virus. J. Bacteriol. 89:1557-1569. 1965.-Several morphological forms characteristic of the poxvirus group were demonstrated for fowlpox virus with neutral phosphotungstic acid (PTA). Viral particles (purified from viral inclusion bodies) stained with uranyl acetate (UA) and shadowed with platinum were shown to have an external knobby surface not evident with PTA. The external coat of freshly purified viral particles seemed intact, but as the preparation aged, it appeared to unwind, resulting in twisted "rope-like" structures. This process was facilitated by use of 1% trypsin, and three dense fibrils were identified with UA within the partially detached viral coat. Studies with alkaline PTA (pH 9) were interpreted as revealing a complex nucleoid, but solutions above this pH damaged the particles. The morphology of the nucleoid was better depicted in ultrathin sections of whole virus which, when stained with UA, revealed dense coiled threads. Treatment of virus with sodium lauryl sulfate exposed an underlying coat consisting of small subunits approximately 40 A in diameter. Of great interest was the demonstration that the detergent removed strands of deoxyribonucleic acid (DNA) from the virus without destroying the contour of the particle. The origin of the strands was definitely the fine uranophilic, coiled threads of the nucleoid, which probably represent the DNA molecule(s). That the extracted material was largely DNA was proved by digestion with deoxyribonuclease and resistance to ribonuclease and trypsin. These studies illustrate how a variety of electron microscopic techniques may be utilized alone or in combination to reveal hitherto undescribed fine structure of viral particles.


ENZYMATIC HYDROLYSIS OF YEAST CELL WALLS. I. ISOLATION OF WALL-DECOMPOSING ORGANISMS AND SEPARATION AND PURIFICATION OF LYTIC ENZYMES. Tanaka, Hirosato (University of California, Davis), and Herman J. Phaff. Enzymatic hydrolysis of yeast cell walls. I. Isolation of wall-decomposing organisms and separation and purification of lytic enzymes. J. Bacteriol. 89:1570-1580. 1965.-A number of microorganisms, able to decompose and grow on yeast cell walls, were isolated from soil. These isolates demonstrated various types of attack on yeast walls. A bacterium, identified as Bacillus circulans, and a species of Streptomyces produced clear, lysed zones when grown on an agar medium containing baker's yeast cell walls. The streptomycete formed glucanase, mannanase, and protease, but B. circulans produced only glucanases. Purified mannan could be prepared from the culture fluid of B. circulans grown on baker's yeast cell walls. In a liquid, mineral medium, extracellular lytic enzyme production by B. circulans was optimal after 3 days of aerobic growth at 30 C with 0.5% baker's yeast cell walls as the carbon source. Twelve other carbon sources were ineffective as inducers. Among a number of polysaccharides tested, the crude enzymes of B. circulans hydrolyzed only beta-1-->3 glucan (laminarin) and beta-1-->6 glucan (pustulan), both by a random mechanism, to a mixture of dimer and glucose. The beta-1-->3 and beta-1-->6 glucanases were separated from each other by diethylaminoethyl cellulose column chromatography. Water-soluble oat glucan, which contains in the linear chain both beta-1-->3 and beta-1-->4 bonds, was also hydrolyzed by the bacterial beta-1-->3 glucanase. The products of this reaction indicated that this enzyme hydrolyzes beta-1-->3 or beta-1-->4 glucosidic linkages, provided the beta-glucopyranosyl units composing these bonds are substituted in the 3 position by another glucose unit.


ISOLATION OF L FORMS FROM GROUP A STREPTOCOCCI EXPOSED TO BACITRACIN. Rotta, Jiri (Washington University School of Medicine, St. Louis, Mo.), Walter W. Karakawa, and Richard M. Krause. Isolation of L forms from group A streptococci exposed to bacitracin. J. Bacteriol. 89:1581-1585. 1965.-L forms were obtained from group A streptococci by exposure to bacitracin on gradient plates, although novobiocin was ineffective in this respect. Subcultures of these L forms had morphological and bacteriological properties similar to those obtained with penicillin. M protein was detected in L-form colony smears by immunofluorescent staining with type-specific conjugate. The L forms were not stained with group-specific conjugate. Parallel precipitin tests performed with extracts from a heavy growth of L forms on agar confirmed these findings. Thus, the L forms obtained with bacitracin continue to produce M protein but are devoid of the group-specific carbohydrate which is a major component of cell-wall structure.


FLAGELLA OF SALMONELLA TYPHIMURIUM SPHEROPLASTS. Vaituzis, Z. (University of Maryland, College Park), and R. N. Doetsch. Flagella of Salmonella typhimurium spheroplasts. J. Bacteriol. 89:1586-1593. 1965.-The flagella of penicillin-induced spheroplasts of Salmonella typhimurium were examined by electron and light microscopy. The process of spheroplast formation was followed for a period of 20 hr from its inception. Flagella were found to be confined to those areas of the spheroplast where cell-wall fragments remained. Flagella disappeared as the spheroplasts aged. Spheroplasts produced from nonflagellated organisms were found incapable of synthesizing flagella. Upon inactivation of the penicillin, however, flagella again were synthesized by spheroplasts during reversion to their original rod form. Flagella formation, it is suggested, is dependent on prior synthesis of the normal cell wall. The morphology of the microorganisms at the time of appearance of new flagella is described.


DEMONSTRATION OF A MINIMUM OXIDATION-REDUCTION POTENTIAL REQUIREMENT FOR TRICHOMONAS VAGINALIS.


ELECTRON MICROSCOPIC OBSERVATIONS OF A REMARKABLE BODY IN AGED CORYNEBACTERIUM DIPHTHERIAE.


INTERNAL MEMBRANOUS STRUCTURE IN BACILLUS MACERANS SPORES.


GROWTH MEDIA FOR TYPING GROUP A STREPTOCOCCI.


GERMINATION OF SPORES OF BACILLUS MEGATERIUM WITH DIVALENT METAL-DIPICOLINATE CHELATES.


INFLUENCE OF 2,4,5-TRICHLOROPHENOXYACETIC ACID ON STAPHYLOCOCCAL PENICILLINASE.


INCIDENCE OF CLOSTRIDIUM PERFRINGENS IN THE LIVERS OF CONVENTIONAL AND GNOTOBIOTIC MICE.


ANTILEPTOSPIRAL ACTIVITY OF NORMAL SERUM.


[INTERFERENCE WITH COXIELLA BURNETII INFECTIONS OF  GUINEA PIGS BY INFLUENZA A VIRUS].


LABORATORY INFECTION WITH A LACTOSE-FERMENTING STRAIN OF SALMONELLA TYPHI.


PARAMAGNETIC ABSORPTION OF SINGLE CRYSTALS OF SUCCINIC ACID IRRADIATED AT LOW TEMPERATURE.


SYNTHETIC METAL CHELATORS WHICH REPLACE THE NATURAL GROWTH-FACTOR REQUIREMENTS OF ARTHROBACTER TERREGENS.


SPIN-ECHO STUDIES OF CHEMICAL EXCHANGE. II. CLOSED FORMULAS FOR TWO SITES.


TEMPERATURE CHARACTERISTIC OF THE EXPANSION OF CHLORPROMAZINE.


VISUAL INTENSITY DISCRIMINATION IN CATS AFTER SERIAL TECTAL AND CORTICAL LESIONS.


ORIENTING BEHAVIOR AND THE S-R SPATIAL DISCONTIGUITY EFFECT IN MONKEYS.


CARBOHYDRATE COMPONENTS OF ANTIBIOTICS. IV.


HEMORRHAGE IN THE NEWBORN.

HEMORRHAGE IN THE NEWBORN.


POSTRUBELLA THROMBOCYTOPENIC PURPURA.

POSTRUBELLA THROMBOCYTOPENIC PURPURA.


HEREDITARY NEPHRITIS AND DEAFNESS.

HEREDITARY NEPHRITIS AND DEAFNESS.


RITTER'S DISEASE.

RITTER'S DISEASE.


FOREIGN BODIES IN THE ALIMENTARY TRACT OF INFANTS AND CHILDREN.


THYMIC ALYMPHOPLASIA WITH PANCREATIC FIBROSIS AND MUCOVISCIDOSIS.


COPPER SULFATE AS AN EMETIC.

COPPER SULFATE AS AN EMETIC.


SYMPOSIUM ON TECHNICAL SURGERY AND UNDERGRADUATE MEDICAL EDUCATION.INTRODUCTION.


TOWARD THE RESOLUTION OF TOWN VERSUS GOWN.


THE CHROMOSOMAL COMPLEMENT OF HUMAN SOLID TUMORS. II. KARYOTYPES OF GLIAL TUMORS.


INTERNAL DOSIMETRY STUDIES OF RADIOPHARMACEUTICALS. II. SODIUM IODOHIPPURATE 1-131.


AN AUTOMATICALLY CONTROLLED WASHING PROCEDURE FOR I-132 GENERATORS.


SOME ASPECTS OF GLUCOSE METABOLISM OF CHROMIUM-DEFICIENT RATS RAISED IN A STRICTLY CONTROLLED ENVIRONMENT.


DIETARY PECTIN AND BLOOD CHOLESTEROL.

DIETARY PECTIN AND BLOOD CHOLESTEROL.


EFFECT OF CASEIN AND SOY PROTEIN DIETS ON THE GROWTH OF DUCKLINGS.


THE UTILIZATION OF  ETHANOL. 3. LIVER CHANGES INDUCED BY ALCOHOL.


CERTAIN FACTORS INCLUDING FLUORIDE WHICH AFFECT MAGNESIUM  CALCINOSIS IN THE DOG AND RAT.


USE OF FREE AMINO ACID CONCENTRATIONS IN BLOOD PLASMA IN EVALUATING THE AMINO ACID ADEQUACY OF INTACT PROTEINS FOR CHICK GROWTH. I. FREE AMINO ACID PATTERNS OF BLOOD PLASMA OF CHICKS FED UNHEATED AND HEATED FISHMEAL PROTEINS.


CHROMIUM, CADMIUM AND LEAD IN RATS: EFFECTS ON LIFE SPAN, TUMORS AND TISSUE LEVELS.


USE OF FREE AMINO ACID CONCENTRATIONS IN BLOOD PLASMA IN EVALUATING  THE AMINO ACID ADEQUACY OF INTACT PROTEINS FOR CHICK GROWTH. II. FREE AMINO ACID PATTERNS OF BLOOD PLASMA OF CHICKS FED SESAME AND RAW, HEATED AND OVERHEATED SOYBEAN MEALS.


INFLUENCE OF MEDIUM-CHAIN TRIGLYCERIDE (MCT) ON CHOLESTEROL METABOLISM IN RATS.


CHEMICAL PATHOLOGY OF ACUTE AMINO ACID DEFICIENCIES. 8. INFLUENCE OF AMINO ACID INTAKE ON THE MORPHOLOGIC AND BIOCHEMICAL CHANGES IN YOUNG RATS FORCE-FED A THREONINE-DEVOID DIET.


METABOLIC PATTERNS IN PREADOLESCENT CHILDREN. XVI. RIBOFLAVIN UTILIZATION IN RELATION TO NITROGEN INTAKE.


EFFECTS OF ZINC DEFICIENCY ON PLASMA PROTEINS OF YOUNG JAPANESE QUAIL.


EFFECT OF DIETARY PROTEIN ON THE DEVELOPMENT OF VITAMIN K DEFICIENCY IN THE RAT.


A-NORSTEROIDS. KETALIZATION OF A-NORTESTOSTERONE.


ACQUIRED DISACCHARIDE INTOLERANCE IN MALNUTRITION.


THE EFFECT OF CUPRIC ION ON THE RADIATION CHEMISTRY OF AQUEOUS GLYCINE.


OPTICAL ROTATORY DISPERSION OF L-CYSTEINE-COBALT SYSTEMS.


FRACTURES OF THE ODONTOID PROCESS.

FRACTURES OF THE ODONTOID PROCESS.


NUTRITIONAL CONDITIONS AFFECTING THE RATE OF GLUCOSE PRODUCTION IN FED AND FASTING FEMALE DOGS.


PARATHYROID HORMONE AND URINARY HYDROXYPROLINE.


STROKES--DIAGNOSIS AND MODERN TREATMENT. (I).


COMMON PITFALLS IN MANAGEMENT OF ANEMIA.


THE PSYCHIATRIC SERVICE IN THE GENERAL HOSPITAL.


NUTRIENT REQUIREMENTS IN PSORIASIS.

NUTRIENT REQUIREMENTS IN PSORIASIS.


CONSTRICTIVE FORCES OF PANTY GIRDLE ON THIGH.


CARCINOMA OF THE STOMACH.

CARCINOMA OF THE STOMACH.


INTERPRETING STATISTICS: AN ART.

INTERPRETING STATISTICS: AN ART.


COMPARISONS OF TEST SCORES IN PSYCHIATRIC NURSING.


TOWARD MORE PRECISE EVALUATION OF PATIENT'S NEEDS.


THE NURSE AND MEDICAL RESEARCH.

THE NURSE AND MEDICAL RESEARCH.


NURSING IN AN ENVIRONMENTAL HEALTH STUDY.


NONPROFESSIONAL INTERVIEWERS IN EPIDEMIOLOGIC RESEARCH.


NURSE INTERVIEWERS ON A HEALTH RESEARCH TEAM.


PERCEPTIONS OF A RESEARCH INTERVIEWER.

PERCEPTIONS OF A RESEARCH INTERVIEWER.


STUDENTS' DISAPPOINTMENTS IN PUBLIC HEALTH NURSING.


PRECEPTS FOR A METHOD STUDY.

PRECEPTS FOR A METHOD STUDY.


COMPARISON OF TEACHING METHODS IN MATERNAL AND INFANT CARE.


A PHOTO FINISH FOR RECRUITMENT.

A PHOTO FINISH FOR RECRUITMENT.


ARTERIAL SURGERY FOR NURSES. 7. PALLIATIVE PROCEDURES, OUTPATIENT CONSERVATIVE MEASURES, AMPUTATIONS.


TUBERCULOSIS PATIENTS AND NURSE SPECIALISTS.


THE BRAIN PATTERNS OF THE FISH HYBRIDS PRODUCED BETWEEN GNATHOPOGON ELONGATUS ELONGATUS AND PSEUDORASBORA PARVA.


CYTOLOGICAL STUDIES OF TUMORS. XLI. CHROMOSOMAL INSTABILITY IN HUMAN CHORIONIC LESIONS.


HISTOCHEMICAL STUDIES ON THE DISTRIBUTION OF ALKALINE PHOSPHATASE IN EARLY HUMAN EMBRYOS. 3. EMBRYOS IN STREETER'S HORIZON XII.


DEGRADATION OF PROTEINS OF M.

DEGRADATION OF PROTEINS OF M.


CELLULAR MORPHOLOGY OF EXPLANTED SPLEEN AND KIDNEY OF NEWBORN, ADULT AND SENILE RATS.


PROTEOLYTIC ACTIVITY OF ISOLATED PROTEIN FRACTIONS IN NORMAL AND DENERVATED MUSCLE.


INTRACELLULAR WATER AND DENSITY OF SINGLE MUSCLE FIBRES IN THE CRAYFISH.


MECHANICAL ASPECTS OF MUSCLE CONTRACTION DURING ACTIVITY.


MECHANICAL ASPECTS OF DENERVATED MUSCLE CONTRACTIONS.


POSTNATAL DEVELOPMENT OF MUSCLE FIBRES AND CAPILLARIES IN THE RAT HEART.


TRIGLYCERIDE AND FREE  FATTY ACID CONTENT OF SERUM, LUNGS, LIVER AND ADIPOSE TISSUE DURING POSTNATAL DEVELOPMENT OF THE RAT. THE EFFECTS OF STARVATION  AND OLIVE OIL ADMINISTRATION.


PLEURAL, TRACHEAL AND ABDOMINAL PRESSURE VARIATIONS IN DEFENSIVE AND PATHOLOGIC REFLEXES OF THE RESPIRATORY TRACT.


EVOKED CORTICAL RESPONSES IN X-IRRADIATED RATS.


THE EFFECT OF GLUCOSE AND AGE ON THE IN VITRO OXYGEN CONSUMPTION OF THE RAT BRAIN.


THE ACTIVITY OF ENZYME INVOLVED IN THE BIOGENESIS OF STEROIDS IN THE ADRENAL GLANDS OF YOUNG RATS.


ANTI-THYROTROPHIN RELEASING FACTOR (TRF) ACTIVITY OF SYNTHETIC 3-VALINE-OXYTOCIN.


PARTICIPATION OF CHANGES IN PULMONARY VENTILATION AND UTILIZATION OF OXYGEN FROM INSPIRED AIR IN THE INCREASE  IN OXYGEN CONSUMPTION DURING PHYSICAL EXERTION MEASURED REPEATEDLY IN BOYS.


THE FUTURE OF THE PROSTHETIC-ORTHOTIC INDUSTRY AND PROFESSION.


A CASE WORK EXPERIENCE WITH PATIENTS FOLLOWING LOSS OF LARYNX.


CHLOROQUINE RESISTANCE IN PLASMODIUM FALCIPARUM IN  BRAZIL.


PULMONARY DIFFUSING CAPACITY FOR CARBON MONOXIDE IN RELATION TO CARDIAC OUTPUT IN MAN.


A NOVEL CONSTITUENT OF AMANITA MUSCARIA.


ON THE BIOSYNTHESIS OF THE 2-N-ALKYL-4-HYDROXYQUINOLINES OF PSEUDOMONAS AERUGINOSA (SCHROET.) MIGULA.


PROTECTIVE ACTION BY THIOURACIL AGAINST THE ACUTE TOXICITY IN MICE OF O-ETHYL O-(4-NITROPHENYL) PHENYLPHOSPHONOTHIOATE (EPN).


MULTIPLE-CRYSTAL-POSITION TECHNIQUE FOR WHOLE-BODY MEASUREMENTS. ANL-6839.


RADIOLOGICAL PHYSICS DIVISION ANNUAL REPORT, JULY 1963 THROUGH JUNE 1964. ANL-6938.


DISTRIBUTION OF RADIUM IN HUMANS. ANL-6839.


SOME PROBLEMS OF ACCURATE MEASUREMENT OF POTASSIUM IN MAN. ANL-6839.


RADIUM RETENTION IN MICE. I. AFTER SINGLE INTRAVENOUS INJECTION. ANL-6839.


CS137 TRENDS IN HUMANS FROM 1955 TO 1964. ANL-6839.


LONG-TERM EFFECTS OF RADIUM DEPOSITION IN MAN: PROGRESS REPORT. ANL-6839.


TECHNICAL CONCEPT -- OPERATION HENRE. CEX-65.02.


MOBILE RADIOLOGICAL MEASURING UNIT: DESCRIPTION AND OPERATING INFORMATION. CEX-63.11.


RADIOLOGICAL ASPECTS OF SNAPTRAN 2/10A-3 DESTRUCTIVE TEST. IDO-17038.


EDP PROCEDURES IN TECHNICAL LIBRARY OPERATIONS. IDO-16881.


TRANSPORT OF RELATIVELY INSOLUBLE MATERIALS FROM LUNG TO LYMPH NODES. LF-21.


ULTRAMICRO METHODS IN BIOCHEMISTRY. V. A COMPARISON OF THE ULTRAMICRO DETERMINATION OF PHOSPHORUS USING N-PHENYL-P-PHENYLENEDIAMINE OR 1-AMINO-2-NAPHTHOL-4-SULFONIC ACID. VI. THE DETERMINATION OF SERUM ALKALINE PHOSPHATASE. LF-20.


COMPARISON OF PROTECTION AGAINST X- AND GAMMA RADIATION BY AET PLUS 5-HT.


X-IRRADIATION PROTECTION STUDIES. 3. TOTAL DOSE AND RATE EFFECTS IN X-RAY PROTECTION STUDIES. UCLA-12-547.


A DUAL LUNG SCANNING TECHNIQUE FOR EVALUATION OF PULMONARY FUNCTION. UCLA-12-556.


CHEMICAL PROTECTION IN HEALTH PHYSICS.

CHEMICAL PROTECTION IN HEALTH PHYSICS.


DISPOSAL OF AM-241-PU-239 RAFFINATE SOLUTIONS BY FIXATION WITH CEMENT. LA-3150-MS.


BETA-GAMMA RADIOACTIVITY IN ENVIRONMENTAL AIR AT LOS ALAMOS, NEW MEXICO, FOR 1964. LA-3245-MS.


THE RETENTION OF STRONTIUM-90 BY FETAL AND NEWBORN RATS. UR-661.


CHANGES IN KINETICS OF ERYTHROPOIESIS AS REFLECTED IN FREQUENCY DISTRIBUTION OF ERYTHROCYTE VOLUMES OF ACUTELY BLED DOGS. UR-662.


A METHOD OF ANALYSIS OF AIR SAMPLING DATA FOR PARTICULATE ALPHA EMITTERS IN A RADON-THORON DAUGHTER ATMOSPHERE. UR-658.


A DILUENT FOR USE IN SIZING DOG ERYTHROCYTES. UR-659.


THE EFFECTS OF IONIZING RADIATIONS ON THE BIOCHEMISTRY OF MAMMALIAN TISSUES. QUART PROGR REP 54.


THE EFFECTS OF IONIZING RADIATIONS ON THE BIOCHEMISTRY OF MAMMALIAN TISSUES. QUART PROGR REP 55.


PHARMACOLOGICAL OR TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. QUART PROGR REP 54.


PHARMACOLOGICAL AND TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. QUART PROGR REP 55.


THE INFLUENCE OF EXPOSURE TO LOW LEVELS OF GAMMA AND FAST NEUTRON IRRADIATION ON THE LIFE SPAN OF ANIMALS. I. HYPERBARIC OXYGEN EXPOSURE AND RADIATION MORTALITY IN ANIMALS. QUART PROGR REP 55.


BIOCHEMICAL BEHAVIOR OF LEAD. II. LEAD CONTENT OF ORGANS OF RABBIT ADMINISTERED WITH LEAD.


CLINICAL STUDIES ON HYPERTENSION. II. CLINICAL OBSERVATION ON BASIC DISEASES OF MALIGNANT HYPERTENSION WITH SPECIAL CONSIDERATION OF ITS PROGNOSIS.


HUGE HEMANGIOMA OF THE LUNG REPORT OF A CASE WITH AUTOPSY FINDINGS.


REFLUX OF DUODENAL CONTENTS INTO THE BILIARY DUCT.


TRINITY OF SUPERIOR COLLICULUS, VESTIBULAR AND FASTIGIAL NUCLEUS AS CENTERS OF EQUILIBRIUM. AN EVALUATION OF STEREOTAXIC OPERATION OF FASTIGIAL NUCLEUS AS TREATMENT OF CEREBRAL SPASTIC PALSIES.


PHYSIOLOGICAL SIGNIFICANCE OF CARNOSINE, ANSERINE AND RELATED COMPOUNDS IN  MUSCLE-CONTRACTION. I. OXYTOCIC ACTIVITY OF CARNOSINE, ANSERINE AND RELATED COMPOUNDS.


EMG AND CONDUCTION VELOCITY STUDIES IN CHRONIC MANGANESE POISONING.


TUBERCULOSIS IN ALASKA IN 1965.

TUBERCULOSIS IN ALASKA IN 1965.


WATER QUALITY CRITERIA FOR EUROPEAN FRESHWATER FISH. REPORT ON FINELY DIVIDED SOLIDS AND INLAND FISHERIES. (EIFAC TECHNICAL PAPER. 1).


TUBERCULOSIS MENINGITIS AMONG ALASKAN NATIVES.


CHARACTERISTICS OF HOUSING FOR THE YUKON-KUSKOKWIM DELTA OF SOUTHEASTERN ALASKA.


GY (PEANUT) FACTOR IN BLOODS OF MACACA SPECIOSA.


METABOLISM OF VOLATILE ANESTHETICS.

METABOLISM OF VOLATILE ANESTHETICS.


A CASE REPORT OF SUSPICIOUS EPIDEMIC HEMORRHAGIC FEVER.


MAZE LEARNING AND VISUAL DISCRIMINATION IN THE WOOD ANT (FORMICA RUFA).


ON THE SOLVING OF CODE ITEMS DEMANDING THE USE OF INDIRECT PROCEDURES.


ON THE INTERACTION OF S-R COMPATIBILITY WITH OTHER VARIABLES AFFECTING REACTION TIME.


RECENCY IN TWO-CHOICE GUESSING TASKS.

RECENCY IN TWO-CHOICE GUESSING TASKS.


BINOCULAR BRIGHTNESS AVERAGING AND CONTOUR INFORMATION.


PATTERNS OF REACTION TIME RESPONSES.

PATTERNS OF REACTION TIME RESPONSES.


CHANGES IN IMMEDIATE MEMORY WITH AGE.

CHANGES IN IMMEDIATE MEMORY WITH AGE.


SOME CONFIRMATORY RESULTS ON AGE DIFFERENCES IN MEMORY FOR SIMULTANEOUS STIMULATION.


THE TRANSFER OF POSITIVE AND NEGATIVE LEARNING BY NORMAL AND SEVERELY SUBNORMAL CHILDREN.


THE EFFECT OF ATTENTION ON THE SLOPE OF GENERALIZATION GRADIENTS.


VISUAL IMAGERY PRODUCED BY RHYTHMIC PHOTIC STIMULATION: PERSONALITY CORRELATES AND PHENOMENOLOGY.


DIFFERENCES IN THE EGG MORPHOLOGY AND CERTAIN BIOLOGICAL CHARACTERISTICS OF SOME AFRICAN AND MIDDLE EASTERN SCHISTOSOMES, GENUS SCHISTOSOMA, WITH TERMINAL-SPINED EGGS. There is some confusion regarding the differentiation of African and Middle Eastern schistosomes with terminal-spined eggs. In an attempt to clarify the situation, the author has separated the members of the genus Schistosoma that have terminal-spined eggs into three broad groups and five species on the basis of egg morphology and certain biological characteristics.THE GROUPS ARE: the haematobium group, with one species (S. haematobium); the bovis group, with three species (S. bovis, S. mattheei and S. leiperi); and the intercalatum group, with one species (S. intercalatum). Further species separation is not thought to be justified yet, and reasons are given for considering S. capense and S. curassoni as synonymous with S. haematobium and S. mattheei respectively.


BIOCHEMICAL LABORATORY TESTS IN VIRAL HEPATITIS AND OTHER HEPATIC DISEASES. EVALUATION AND FOLLOW-UP. The differential diagnosis between viral hepatitis and other liver diseases (particularly obstructive jaundice) is often difficult on purely clinical grounds. Damage to the liver causes changes in the pattern of the serum enzymes and this has led to the development in recent years of a number of enzyme tests. The authors have amassed evidence to show that the most useful of these is determination of the levels of serum glutamic oxalacetic and serum glutamic pyruvic transaminase (SGOT and SGPT), coupled with calculation of the SGOT/SGPT ratio. It is characteristic of viral hepatitis that both levels are greatly increased, but the SGOT/SGPT ratio, normally greater than one, falls considerably below his figure. In a few cases of obstructive jaundice, the serum transaminase picture may initially resemble that in viral hepatitis, but the differential diagnosis can be established by repeating the determinations at intervals. Other enzyme tests, such as determination of alkaline phosphatase and leucylaminopeptidase, may be used to confirm the biliary obstruction. Flocculation tests and electrophoretic determination of the plasma protein picture, while of limited value in the diagnosis of acute viral hepatitis, are useful in conjunction with the serum transaminase test for assessing the activity of the disease and any tendency to progress towards "active" chronic hepatitis or post-hepatic cirrhosis.


SOME FURTHER OBSERVATIONS ON SCHISTOSOME TRANSMISSION IN THE  EASTERN TRANSVAAL. By immersing groups of rodents into several types of natural waters at Malelane, Eastern Transvaal, and subsequently recovering schistosomes from them, the authors have shown that there is seasonal transmission, which is more marked with Schistosoma mansoni than with S. mattheei. Laboratory confirmation of this periodicity was obtained by infecting groups of snails with the appropriate parasite and studying the pattern of sporocyst development and cercarial shedding under outdoor conditions. It was also found that, apart from seasonal periodicity, the amount of transmission is dependent on the density of human population, the proximity of the definitive host to the immersion site, the degree to which the water is protected from pollution and the distance downstream from the polluting source.Negligible numbers of S. haematobium adults were recovered; possible reasons for this are discussed.The authors consider that an annual transmission cycle may be more common in bilharziasis than is generally supposed-although not exclusively or necessarily for the reasons given in this paper-and suggest that such a cycle be taken into consideration in the planning of control schemes.


A SIMPLE METHOD OF SERUM PROTEIN FRACTIONATION ON CELLULOSE ACETATE AND A COMPARISON OF THE ALBUMIN LEVELS WITH A METHOD OF SODIUM SULPHITE FRACTIONATION.


A CHEMICAL METHOD FOR THE DETERMINATION OF NATURAL AND SEMISYNTHETIC PENICILLINS IN BIOLOGICAL MATERIAL.


PLASMA GLYCOPROTEINS IN DISEASES OF THE HEMOPOIETIC SYSTEM.


IDENTIFICATION BY MEANS OF L-PHENYLALANINE INHIBITION OF INTESTINAL ALKALINE PHOSPHATASE COMPONENTS SEPARATED BY STARCH GEL ELECTROPHORESIS OF SERUM.


DETERMINATION OF DESFERRIOXAMINE-B METHANE SULPHONATE IN URINE.


FINGERPRINTING THE HYALURONIC ACID-PROTEIN COMPLEX OF HUMAN VITREOUS HUMOUR.


LACTATE DEHYDROGENASE ISOENZYMES: IRREGULARITIES IN ELECTROPHORETIC MOBILITY.


PREPARATION OF A CAM FOR THE SCANNING OF PAPER ELECTROPHEROGRAMS ON THE CHROMOSCAN DENSITOMETER.


SPECTROPHOTOMETRIC DETERMINATION OF ABNORMAL HEMOGLOBIN PIGMENTS IN BLOOD.


THE RENAL TUBULAR REABSORPTION OF PHOSPHATE IN THYROTOXICOSIS.


DETERMINATION OF IRON IN FAECES.

DETERMINATION OF IRON IN FAECES.


RELATIVE MOBILITIES OF LDH ISOENZYMES IN HUMAN BLOOD SERUM AFTER ADDITION OF NAD.


DIFFERENCE IN CHROMATOGRAPHIC BEHAVIOUR OF ALDOSTERONE AND (1,2-H3)-ALDOSTERONE.


RECENT ATTEMPTS AT THE PURIFICATION AND IDENTIFICATION OF HUMAN PLACENTAL "HISTAMINASE".


SKIN L-HISTIDINE AMMONIA-LYASE ACTIVITY IN THE FAMILY OF A CHILD WITH HISTIDINAEMIA.


A CASE OF SUCROSE SYNTHESIS IN THE HUMAN ORGANISM.


WORK SIMPLIFICATION APPLIED TO DENTAL PRACTICE: A PROGRESS REPORT.


MOTIVATING PATIENTS TO ACCEPT PREVENTIVE SERVICES.


A METHOD TO INCORPORATE A FIXED HORIZONTAL PIN SPLINT WITH A VENEER CROWN AS A SINGLE SPLINT.


TEMPORARY ACRYLIC INLAYS.

TEMPORARY ACRYLIC INLAYS.


A SCIENTIFIC STUDY OF MYSTERY: THE ROLE OF THE MEDICAL AND POPULAR PRESS IN THE NANCY-SALP ETRI'ERE CONTROVERSY ON HYPNOTISM.


CHEMOTHERAPY IN DENTAL PRACTICE.

CHEMOTHERAPY IN DENTAL PRACTICE.


CLINICAL CONFERENCE.

CLINICAL CONFERENCE.


A PRACTICAL PROCEDURE FOR AN ACCURATE ANATOMIC FACE-BOW REGISTRATION.


RADIOLOGICAL ANALYSIS OF LESIONS OF THE UPPER INTESTINAL TRACT DURING A FOUR-YEAR PERIOD IN AFRICANS IN TANGANYIKA (NOW TANZANIA).


THE LONG TERM USE OF CHOLESTYRAMINE IN THE TREATMENT OF PRIMARY BILIARY CIRRHOSIS.


URINARY HYDROXYPROLINE EXCRETION IN MALABSORPTION STATES.


INFLUENCE OF PARATHYROID EXTRACT ON GASTRIC MUCOSAL CONTENT OF MUCUS.


THE PANCREAS. IV.

THE PANCREAS. IV.


MALAKOPLAKIA OF THE COLON.

MALAKOPLAKIA OF THE COLON.


TOPOGRAPHY OF COTRANSDUCIBLE ARGININE MUTATIONS IN ESCHERICHIA COLI K-12.


CHROMOSOME EXCHANGES IN HUMAN LEUKOCYTES INDUCED BY MITOMYCIN C.


THE NATURE OF INDUCED EXCHANGES BETWEEN THE ATTACHED-X AND Y CHROMOSOMES IN DROSOPHILA MELANOGASTER FEMALES.


CHROMOSOME STRUCTURE AND CROSSING OVER.

CHROMOSOME STRUCTURE AND CROSSING OVER.


BLOOD GROUPS OF TURKEYS.

BLOOD GROUPS OF TURKEYS.


THE EFFECT OF LITTER SIZE OF CROSSING INBRED STRAINS OF MICE.


GENETICAL AND BIOCHEMICAL STUDIES OF HISTIDINE-REQUIRING MUTANTS OF NEUROSPORA CRASSA. 3. CORRESPONDENCE BETWEEN BIOCHEMICAL CHARACTERISTICS AND COMPLEMENTATION MAP POSITION OF HIST-3 MUTANTS.


MEIOTIC BEHAVIOR OF TANDEM ME TACENTRIC COMPOUND X CHROMOSOMES IN DROSOPHILA MELANOGASTER.


A RECESSIVE LECTIN-FACTOR IN STREPTOPELIA RISORIA.


SEGREGATION-DISTORTION AND REGULARLY NONFUNCTIONAL PRODUCTS OF SPERMATOGENESIS IN DROSOPHILA MELANOGASTER.


GENETICAL AND BIOCHEMICAL STUDIES OF HISTIDINE-REQUIRING MUTANTS OF NEUROSPORA CRASSA. IV. LINKAGE RELATIONSHIPS OF HIST-3 MUTANTS.


MERGER, AMALGAMATION, UNIFICATION, CONFEDERATION.


CLINICAL TRIAL OF DEHYDROEMETINE (RO 1-9334) IN AMOEDIASIS.


FACTORS INFLUENCING THE ABSORPTION OF A MEDIUM CHAIN TRIGLYCERIDE.II. THE ROLE OF PANCREATIC JUICE IN THE INTRALUMINAL PHASE OF ABSORPTION.


DISMUTATION REACTIONS OF NUCLEOSIDE POLYPHOSPHATES. II. SPECIFIC CHEMICAL SYNTHESES OF ALPHA-, BETA-, AND GAMMA-P32-NUCLEOSIDE 5'-TRIPHOSPHATES.


ADRENOCORTICOTROPINS. 33. SYNTHESIS OF A BIOLOGICALLY ACTIVE HEXACOSAPEPTIDE CORRESPONDING TO THE FIRST 26 RESIDUES OF BOVINE ACTH.


THE EXCHANGE LABELING OF KETO STEROIDS WITH TRITIUM BY ADSORPTION CHROMATOGRAPHY ON BASIC ALUMINA.


ADRENOCORTICOTROPINS. XXXIV. ASPECTS OF STRUCTURE--ACTIVITY RELATIONSHIPS OF THE ACTH MOLECULE. SYNTHESIS OF A HEPTADECAPEPTIDE AMIDE, AN OCTADECAPEPTIDE AMIDE, AND A NONADECAPEPTIDE AMIDE POSSESSING HIGH BIOLOGICAL ACTIVITIES.


THE SYNTHESIS OF SELENOCOENZYME A.

THE SYNTHESIS OF SELENOCOENZYME A.


DEUTERIUM--HYDROGEN EXCHANGE IN AMIDE N--H GROUPS.


REACTIVITY OF SULFHYDRYL AND DISULFIDE IN PROTEINS. VI. EFFECT OF HEAT DENATURATION OF BOVINE SERUM ALBUMIN (BSA) ON SULFHYDRYL AND REACTIVE DISULFIDE CONTENT.


KINETICS OF PAPAIN-CATALYZED HYDROLYSIS OF ALPHA-N-BENZOYL-L-ARGININE ETHYL ESTER AND ALPHA-N-BENZOYL-L-ARGININAMIDE.


THE USE OF SUBSTITUENT CONSTANTS AND REGRESSION ANALYSIS IN THE STUDY OF ENZYMATIC REACTION MECHANISMS.


THE EFFECT OF STRUCTURAL VARIATION ON THE HYDROLYSIS OF DELTA-2-THIAZOLINES.


ON THE CONFORMATION OF HORSE HEART FERRI- AND FERROCYTOCHROME C.


THE NATURE OF THE COMPLEXITIES IN THE RIBONUCLEASE CONFORMATIONAL TRANSITION AND THE IMPLICATIONS REGARDING CLATHRATING.


PROTON IONIZATION FROM ADENOSINE.

PROTON IONIZATION FROM ADENOSINE.


CIRCULAR DICHROISM OF COPPER(II) COMPLEXES WITH OPTICALLY ACTIVE AMINO ACIDS.


AN EFFICIENT SYNTHESIS OF ESTRONE AND 19-NORSTEROIDS FROM CHOLESTEROL.


MARASMIC ACID.

MARASMIC ACID.


INTERNAL MEDICINE--YES: GERIATRICS--NO.

INTERNAL MEDICINE--YES: GERIATRICS--NO.


ASTERIXIS.

ASTERIXIS.


EPIDEMIOLOGY OF DIABETES MELLITUS IN JAPAN.


CONJOINT CLINIC ON SEROTONIN, NOREPINEPHRINE AND TYRAMINE.


GRAND ROUNDS AT THE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE. I. PROGRESSIVE EXOPHTHALMOS.


GROUND ROUNDS AT THE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE. II. CHROMOSOMAL ABNORMALITIES IN LEUKEMIA.


CORONARY HEART DISEASE AMONG NEGROES AND WHITES IN EVANS COUNTY, GEORGIA.


HAND FUNCTION IN HEMIPLEGIA.

HAND FUNCTION IN HEMIPLEGIA.


THE GASTRO CAMERA. ITS USE, VALUE, AND RECENT DEVELOPMENTS.


WALTER DROWLEY FILMER, 1865-1944: AUSTRALIAN X-RAY PIONEER.


RADIOTHERAPY OF PITUITARY TUMOURS.

RADIOTHERAPY OF PITUITARY TUMOURS.


PULMONARY OPACITIES RESULTING FROM DI-ISOCYANATE EXPOSURE.


VARICELLA PNEUMONIA IN ADULTS.

VARICELLA PNEUMONIA IN ADULTS.


DOUBLE DOSE UROGRAPHY.

DOUBLE DOSE UROGRAPHY.


EARLY HORIZONS OF JUSTICE IN THE WEST.

EARLY HORIZONS OF JUSTICE IN THE WEST.


LIVER SCANNING IN OBSTRUCTIVE JAUNDICE USING COLLOIDAL RADIOGOLD.


A SURVEY OF 902 BARIUM MEAL EXAMINATIONS PERFORMED IN ONE YEAR AT THE QUEEN ELIZABETH HOSPITAL, SOUTH AUSTRALIA.


THE USE OF THE VALSALVA MANOEUVRE IN THE VISUALIZATION OF THE LOWER URETERS DURING INTRAVENOUS PYELOGRAPHY.


GAS IN THE FOETAL VERTEBRAL CANAL: A FURTHER SIGN OF INTRAUTERINE DEATH.


POLAROID PHOTOGRAPHY IN CINE-RADIOLOGY.

POLAROID PHOTOGRAPHY IN CINE-RADIOLOGY.


CALENDAR OF INTERNATIONAL CONGRESSES OF MEDICAL SCIENCES--1965.


THE  ARTIFACTUAL NATURE OF LIPID PEROXIDES DETECTED IN EXTRACTS OF HUMAN AORTA.


MEASUREMENT OF CRYSTAL GROWTH OF ALPHA-LACTOSE.


DIRECT RECOVERY OF ADDED KETONES FROM FOAM-DRIED WHOLE MILK.


DETERMINATION OF POLYUNSATURATED FATTY ACIDS IN MILK FAT.


DIRECT RECOVERY OF OFF FLAVORS FROM FOAM-DRIED WHOLE MILK.


PLASMA LIPIDS IN 6-7 YEAR OLD CHILDREN FROM TWO DIFFERENT REGIONS: A PAEDIATRICIAN'S CONTRIBUTION TO EPIDEMIOLOGICAL RESEARCH ON ATHEROSCLEROSIS.


ROLE OF AMINO ACIDS IN GERMINATION OF BACILLUS LICHENIFORMIS SPORES. I. UPTAKE OF RADIOACTIVE AMINO ACIDS BY GERMINATING AND DORMANT SPORES.


EFFECT OF SANITIZING PROCEDURE ON CHEMICAL ASPECTS OF PROCESS FPR REMOVAL OF RADIONUCLIDES FROM MILK.


PRODUCTION OF VOLATILE FATTY ACIDS BY SOME LACTIC ACID BACTERIA. II. SELECTIVE FORMATION OF VOLATILE FATTY ACIDS BY DEGRADATION OF AMINO ACIDS.


MICROBIOLOGICAL ASPECTS OF THE FIXED-BED PROCESS FOR REMOVAL OF CATIONIC RADIONUCLIDES FROM MILK.


VOLATILE FATTY ACIDS PRODUCED BY SOME LACTIC ACID BACTERIA. I. FACTORS INFLUENCING PRODUCTION OF VOLATILE FATTY ACIDS FROM CASEIN HYDROLYSATE.


PROGESTERONE IN BOVINE REPRODUCTION. A REVIEW.


LUTEOTROPIC PROPERTIES OF LUTEINIZING HORMONE AND NATURE OF OXYTOCIN INDUCED LUTEAL INHIBITION IN CATTLE.


GENETIC AND ENVIRONMENTAL FACTORS IN DAIRY SIRE EVALUATION. I. EFFECTS OF HERDS, MONTHS, AND YEAR-SEASONS ON VARIANCE AMONG LACTATION RECORDS; REPEATABILITY AND HERITABILITY.


EFFECT OF HIGHLY PURIFIED AND COMMERCIAL GRADE GROWTH HORMONE PREPARATIONS ON MILK PRODUCTION OF DAIRY COWS.


GROWTH HORMONE-INDUCED KETOSIS IN THE COW.


GENETIC AND ENVIRONMENTAL FACTORS IN DAIRY SIRE EVALUATION. II. USES AND LIMITATIONS OF DEVIATION RECORDS AND THE ROLE OF DAMS.


GASTROINTESTINAL SITES OF ABSORPTION AND ENDOGENOUS SECRETION OF ZINC IN DAIRY CATTLE.


CALORIC EQUIVALENT OF LIVE WEIGHT LOSS OF DAIRY CATTLE.


METABOLISM OF N-BUTYRATE BY THE ADULT GOAT.


EFFECT OF SUBSTITUTING DRY SUGARS FOR MOLASSES IN CALF STARTERS ON FEED INTAKE AND GROWTH RESPONSE.


LIPID CLASSES OF BOVINE SPERMATOZOA.

LIPID CLASSES OF BOVINE SPERMATOZOA.


LACTULOSE IN MODIFIED MILK PRODUCTS FOR INFANT NUTRITION.


IRRELATION OF KETO STEARIC ACIDS TO FATTY ACID METABOLISM IN THE RUMINANT MAMMARY GLAND.


A PROJECTION FOR THE DENTAL CURRICULUM IN 1975.


EFFECT OF PRELIMINARY INCUBATION (55F/18 HR) ON MICROFLORA OF RAW BULK TANK MILK, WITH SOME OBSERVATIONS ON MICROFLORA OF MILKING EQUIPMENT.


THE QUARTERLY POST.

THE QUARTERLY POST.


REVIEW OF THE HISTORICAL DEVELOPMENT OF DENTAL EDUCATION REQUIREMENTS.


EDUCATING DENTAL STUDENTS TO USE AUXILIARIES: A PROGRESS REPORT.


MERCURY AVOIDANCE IN COLLECTING AND DISPLACING GAS SAMPLES.


COMBINED COURSE IN TECHNICAL AND CLINICAL COMPLETE DENTURE PROSTHODONTICS.


CHANGING CONCEPTS IN DENTAL EDUCATION.

CHANGING CONCEPTS IN DENTAL EDUCATION.


THE DENTAL STUDENT AT THE UNIVERSITY OF ILLINOIS.


ATTITUDES OF SENIOR HIGH SCHOOL STUDENTS TOWARD DENTISTRY AS A CAREER FOR WOMEN.


ORAL PHYSIOLOGY AND CLINICAL DENTISTRY.

ORAL PHYSIOLOGY AND CLINICAL DENTISTRY.


ITEM ANALYSIS--A MEANS OF EVALUATING VALIDITY.


DENTAL STUDENTS' ATTITUDES TOWARDS INTEGRATING OF BASIC SCIENCES AND CLINICAL PRACTICE.


THE FUTURE ROLE OF THE UNIVERSITY.

THE FUTURE ROLE OF THE UNIVERSITY.


CUES BY WHICH CHILDREN RECOGNIZE WORKS.

CUES BY WHICH CHILDREN RECOGNIZE WORKS.


SELECTION OF STUDENTS FOR DENTAL SCHOOL.


CHRONIC DISEASE RESEARCH.

CHRONIC DISEASE RESEARCH.


AN IN VITRO STUDY OF THE RELATIVE MOISTURE OCCLUSIVE PROPERTIES OF SEVERAL TOPICAL VEHICLES AND SARAN WRAP.


TASTE AND THE CHORDA TYPANI.

TASTE AND THE CHORDA TYPANI.


HOST SPECIFICITY OF DNA PRODUCED BY ESCHERICHIA COLI. IV. HOST SPECIFICITY OF INFECTIOUS DNA FROM BACTERIOPHAGE LAMBDA.


ULTRACENTRIFUGAL STUDIES ON THE DISSOCIATION OF HEPATIC RIBOSOMES.


FOURIER SYNTHESIS STUDIES OF LITHIUM DNA. 3. HOOGSTEEN MODELS.


SALT-LOSING CONGENITAL ADRENAL HYPERPLASIA; A REVIEW AND REPORT OF TWO CASES.


STRUCTURE COMPARISON OF THE MAJOR  MONOSIALOGANGLIOSIDES FROM BRAINS OF NORMAL HUMAN, GARGOYLISM, AND LATE INFANTILE SYSTEMIC LIPIDOSIS. I.


MINIMIZING PULPAL REACTIONS WITH PREDNISOLONE THERAPY.


A PRELIMINARY INVESTIGATION OF THE "HOLLOW TUBE" THEORY IN ENDODONTICS: STUDIES WITH NEO-TETRAZOLIUM.


CARDIOVASCULAR RESPONSES DURING GENERAL  ANESTHESIA OF DENTAL OUTPATIENTS.


A STUDY OF THE EFFECT OF STANNOUS FLUORIDE INCORPORATED IN DENTAL CEMENT.


THE EFFECT OF SELENIUM ON WATER INTAKE IN THE RAT.


THE EFFECT OF MANUAL AND MECHANICAL TOOTHBRUSHING ON ORAL HYGIENE, CARIES CONDUCIVENESS AND PH OF THE ORAL CAVITY.


USE OF 2-CHLOROPROCAINE HYDROCHLORIDE AS AN ANESTHETIC AGENT FOR ORAL SURGERY: CLINCIAL IMPRESSIONS.


MATERNAL TRANSFER OF FLUORIDE.

MATERNAL TRANSFER OF FLUORIDE.


PHOSPHONIC ACID ANALOGS OF NUCLEOSIDE PHOSPHATES. 3. THE SYNTHESIS OF ADENOSINE-5'-METHYLENEDIPHOSPHONATE, A PHOSPHONIC ACID ANALOG OF ADENOSINE-5'-DIPHOSPHATE.


KINETICS OF SOLVOLYSES OF VARIOUS  N-ALKYL-N-NITROSOUREAS IN NEUTRAL AND ALKALINE SOLUTIONS.


ADDITIONAL SODIUM CHLORIDE EQUIVALENTS AND FREEZING POINT DEPRESSIONS FOR VARIOUS MEDICINAL SOLUTIONS.


DETERMINATION OF AN EQUILIBRIUM CONSTANT FOR THE DIMERIZATION OF THE BACILLUS SUBTILIS ALPHA-AMYLASE MOLECULE.


SYNTHESIS AND ANTITREMORINE ACTIVITY OF AMINO KETALS.


BIOPHARMACEUTICAL INVESTIGATION OF NALIDIXIC ACID IN MAN.


USES OF CLOSED-CIRCUIT TELEVISION IN THE TEACHING OF DENTISTRY.


THE PHYSICIAN AND THE EMERGENCY HEALTH SERVICES.


MOLECULAR BIOLOGY IN CHINA.

MOLECULAR BIOLOGY IN CHINA.


SPECIFIC ASSAYS OF SOME PHOSPHATASES IN SUBCELLULAR FRACTIONS OF SMALL INTESTINAL MUCOSA.


URINARY BETA-AMINO ISOBUTYRIC ACID IN THE MOUSE: ELIMINATION AFTER INTRAVENOUS ADMINISTRATION OF DEOXYRIBONUCLEIC ACID.


SPARSOMYCIN MODIFICATION OF THE LETHAL ACTION OF IONIZING IRRADIATION ON ESCHERICHIA COLI.


MODIFICATION OF ULTRA-VIOLET ERYTHEMA BY EPIDERMAL STRIPPING.


ANTIGENIC VARIABILITY OF THE STRAINS OF ROUS SARCOMA VIRUS.


THE ANTINUCLEAR FACTOR TEST IN DIAGNOSTICS.


CYTOTOXIC AGENTS IN MALIGNANT DISEASE 1.


ANXIETY NEUROSIS COMPLICATED BY ADDICTION TO SODIUM AMYTAL.


FISSURE IN ANO.

FISSURE IN ANO.


BON VOYAGE.

BON VOYAGE.


THE THEATRE NURSE AND EMERGENCY SURGERY 2. ACUTE APPENDICECTOMY.


DIAGNOSTIC RADIOLOGY AND THE NURSE 7. ANGIOGRAPHY 1.


A 34-YEAR CLINICAL STUDY OF  UTERINE SARCOMA INCLUDING EXPERIENCE WITH CHEMOTHERAPY.


THE INTERNATIONAL STOKE MANDEVILLE GAMES FOR THE PARALYSED: TOKYO, 1964.


VARIOUS FACTORS INFLUENCING ROULEAUX FORMATIONS OF ERYTHROCYTES, STUDIES WITH THE AID OF SYLLECTOMETRY.


COMMENT ON "BENDER GESTALT DISCERNMENT OF ORGANIC PATHOLOGY".


THE GREAT RESPONSE-STYLE MYTH.

THE GREAT RESPONSE-STYLE MYTH.


SUCCESS OF OUTPATIENT CLINICS TIED TO HUMAN, SOCIAL FACTORS.


STABILIZATION OF THE RETINAL IMAGE: A REVIEW OF METHOD, EFFECTS, AND THEORY.


TRIALS WITH TEDIUM AND TITILLATION.

TRIALS WITH TEDIUM AND TITILLATION.


POINTERS TO COUNSELORS OF THE DEAF.

POINTERS TO COUNSELORS OF THE DEAF.


THE MENTAL PATIENT'S VIEW.

THE MENTAL PATIENT'S VIEW.


THE PHYSICIAN AND THE COUNSELOR.

THE PHYSICIAN AND THE COUNSELOR.


THE BLIND AND TODAY'S JOBS.

THE BLIND AND TODAY'S JOBS.


FROM MALINGERERS TO EAGER BEAVERS. REINFORCING WORKING BEHAVIOR IN COMPENSATION CLIENTS.


RETARDATES TRY SOCIAL LIVING.

RETARDATES TRY SOCIAL LIVING.


A LOOK AT ALCOHOLIC REHABILITATION.

A LOOK AT ALCOHOLIC REHABILITATION.


CLINICAL TREATMENT OF ALCOHOLICS.

CLINICAL TREATMENT OF ALCOHOLICS.


CAUSES OF ALCOHOLISM.

CAUSES OF ALCOHOLISM.


FOLLOW-UP AFTER THE HALFWAY HOUSE.

FOLLOW-UP AFTER THE HALFWAY HOUSE.


PROFILE OF FAILURE.

PROFILE OF FAILURE.


KANSAS CITY EPILEPSY PROGRAM.

KANSAS CITY EPILEPSY PROGRAM.


THYMIC TUMOURS WITH RED CELL APLASIA.

THYMIC TUMOURS WITH RED CELL APLASIA.


SERUM LACTATE DEHYDROGENASE IN BRONCHIAL CARCINOMA.


DIFFUSE FIBROSING ALVEOLITIS (DIFFUSE INTERSTITIAL FIBROSIS OF THE LUNGS): TWO CASES WITH AUTOIMMUNE FEATURES.


EXTENSIVE OSSIFICATION IN A PULMONARY PLASMACYTOMA.


BRONCHIAL ATRESIA OF THE LEFT UPPER LOBE.


EXPERIENCE WITH MEDIASTINOSCOPY.

EXPERIENCE WITH MEDIASTINOSCOPY.


PENICILLIN LEVELS IN SPUTUM.

PENICILLIN LEVELS IN SPUTUM.


OESOPHAGO-BRONCHIAL FISTULA IN THE ADULT.


A THREE-BLADED DILATOR FOR TRANS-VENTRICULAR MITRAL VALVOTOMY.


STUDIES OF LEFT ATRIAL PRESSURE DURING CARDIOPLEGIA PRODUCED BY PROFOUND HYPOTHERMIA USING THE CLOSED CHEST TECHNIQUE.


EFFECTS OF LUNG VOLUME CHANGES ON CARDIAC OUTPUT IN MAN.


ANATOMICAL COURSE OF AN OESOPHAGO-GASTRO-DUODENO-JEJUNAL DUPLICATION.


AN X-RAY MICROSCOPIC STUDY OF THE NORMAL ROOT OF NECK ARTERIES IN MAN.


CO-EXISTENT TOTAL  ANOMALOUS PULMONARY VENOUS DRAINAGE INTO PORTAL VEIN, DRAINAGE OF LEFT-SIDED INFERIOR VENA CAVA INTO LEFT ATRIUM, AND SPLENIC AGENESIS.


TREATMENT OF CHYLOTHORAX BY PRODUCING PLEURODESIS USING IODIZED TALC.


HEAT EXCHANGER FOR PROFOUND HYPOTHERMIA.


SURGICAL TREATMENT OF VENTRICULAR SEPTAL DEFECT.


CHANGES IN MEAN SIZE CHILDREN IN SOME JAMAICAN SCHOOLS BETWEEN 1951 AND 1964.


FRACTURE OF THE SHAFT OF THE TIBIA: 492 CONSECUTIVE CASES IN ADULTS.   IMPORTANCE OF SOFT TISSUE INJURY.


ANGIOGRAPHY IN CARCINOMA OF THE PANCREAS.


SINGLE INJECTION CAUDAL ANESTHESIA: REPORT ON 531 DELIVERIES WITH 1.5 PER CENT MEPIVACAINE.


A DOUBLE BLIND STUDY OF THE EFFECT OF TRANQUILIZERS DURING LABOR.


UTERINE CERVIX RIPENING IN TERM PREGNANCY DUE TO THE ACTION OF ESTRADIOL-17-BETA. A  HISTOLOGICAL AND HISTOCHEMICAL STUDY.


ROUTINE VAGINAL EXAMINATIONS DURING LABOR. A COMPARATIVE STUDY WITH BACTERIOLOGICAL ANALYSIS.


SARCOMA ARISING IN A LEIOMYOMA OF THE UTERUS: FACTORS INFLUENCING PROGNOSIS.


INTRAUTERINE TRANSFUSION OF FETUS FOR SEVERE ERYTHROBLASTOSIS FETALIS. A CASE REPORT.


SODIUM TRANSPORT IN THE KIDNEY AND PLACENTA IN NORMAL PREGNANCY AND IN EXPERIMENTAL TOXEMIA.


VAGINOPERINEOTOMY. A NEW TECHNIQUE TO REDUCE THE INCIDENCE OF SYMPTOMATIC RECTOCELE AND THIRD DEGREE PERINEAL LACERATION.


SQUAMOUS CELL CARCINOMA OF THE CERVIX.

SQUAMOUS CELL CARCINOMA OF THE CERVIX.


FURTHER OBSERVATIONS ON THE EFFECTS OF CLOMIPHENE CITRATE IN ANOVULATORY FEMALES.


THE PATHOLOGY OF MELANOCYTIC-MELANOBLASTIC NEOPLASMS OF THE SKIN.


MELANOTIC NEVI IN DERMATOLOGY.

MELANOTIC NEVI IN DERMATOLOGY.


PLASTIC SURGERY AND MELANOTIC NEVI.

PLASTIC SURGERY AND MELANOTIC NEVI.


SOME THOUGHTS ON THERAPY.

SOME THOUGHTS ON THERAPY.


SURGICAL TREATMENT OF ULCERATIVE COLITIS.


SOCIO-CULTURAL ASPECTS IN ALCOHOLISM.

SOCIO-CULTURAL ASPECTS IN ALCOHOLISM.


MANAGEMENT OF ACUTE CHEST INJURIES.

MANAGEMENT OF ACUTE CHEST INJURIES.


REPORT ON ARIZONA SNAKEBITES.

REPORT ON ARIZONA SNAKEBITES.


ENVENOMATION BY SISTRURUS MILIARIUS. REPORT OF TWO CASES OF PYGMY RATTLESNAKE POISONING.


THE CHILD PSYCHIATRIST AND THE JUVENILE DELINQUENT.


A DEFENSE OF THE GLASS TRANSFUSION CONTAINER.


ACTIONS OF DRUGS ON SINGLE NEURONES IN THE CEREBRAL CORTEX.


PHARMACOLOGY OF CENTRAL INHIBITORY SYNAPSES.


ACTIONS OF DRUGS ON SINGLE NEURONES IN THE BRAIN-STEM.


CHOLINERGIC MECHANISMS IN THE CEREBELLUM.


UPTAKE OF ANAESTHETICS AND THEIR ACTION ON THE CENTRAL NERVOUS SYSTEM.


EFFECT OF LYSERGIC ACID DIETHYLAMIDE ON POTENTIALS EVOKED IN THE SPECIFIC SENSORY PATHWAYS.


A NEW EXPERIMENTAL APPROACH TO THE PHYSIOLOGY AND PHARMOCOLOGY OF THE BRAIN.


PHARMACOLOGY OF THE CENTRAL NERVOUS SYSTEM.


EFFECTS OF DRUGS ON METABOLISM OF THE BRAIN IN VITRO.


METABOLISM OF TRYPTAMINE AND RELATED COMPOUNDS IN THE CENTRAL NERVOUS SYSTEM.


EFFECT OF DRUGS ON METABOLISM OF CATECHOLAMINES IN THE BRAIN.


GAMMA-AMINOBUTYRIC ACID AND OTHER INHIBITORY SUBSTANCES.


FACTORS INFLUENCING THE PROTEIN METABOLISM OF THE BRAIN.


OESTROGENS IN THE CENTRAL NERVOUS SYSTEM.


JACKSON BUCCAL SEGMENT YOKE APPLIANCES.

JACKSON BUCCAL SEGMENT YOKE APPLIANCES.


PHOTOGRAPHY IN DAILY PRACTICE.

PHOTOGRAPHY IN DAILY PRACTICE.


PARTIAL ANODONTIA VERA.

PARTIAL ANODONTIA VERA.


DE LANGE'S AMSTERDAM DWARFS SYNDROME. REPORT OF FOUR CASES.


DE LANGE'S AMSTERDAM DWARFS SYNDROME. INTRODUCTORY REVIEW WITH TWO CASE REPORTS.


DE LANGE'S AMSTERDAM DWARFS SYNDROME. A CASE REPORT.


BRIDGES TO BURN AND TO BUILD. A PRESIDENTIAL ADDRESS.


TOTAL PARALYSIS WITHOUT SEDATION IN THE TREATMENT OF SEVERE TETANUS.


TRYPTOPHAN METABOLISM IN PSYCHOTIC CHILDREN. A PRELIMINARY REPORT.


THE EFFECT OF A REDUCTION IN SEVERE TOXAEMIA OF PREGNANCY ON FOETAL SALVAGE.


DE LANGE'S AMSTERDAM DWARFS SYNDROME. REPORT OF TWO CASES.


TRYPTOPHAN-TOLERANCE TESTS AND VITAMIN B6 (PYRIDOXINE) METABOLISM IN EPILEPTIC CHILDREN.


THE DEVELOPMENT OF HUMAN SKELETAL MUSCLE.


THE ANKLE JERK IN THYROID DISEASE AND IN CEREBRAL PALSY.


A PROBABLE EPIDEMIC OF CONGENITAL HYDROCEPHALUS IN 1940-1941.


PYRIDOXINE, TRYPTOPHAN AND EPILEPSY.

PYRIDOXINE, TRYPTOPHAN AND EPILEPSY.


THE BIOLOGY OF PREMATURITY.

THE BIOLOGY OF PREMATURITY.


OBESITY IN CHILDREN.

OBESITY IN CHILDREN.


AGE AND SIZE OF PREMATURE INFANTS.

AGE AND SIZE OF PREMATURE INFANTS.


FATIGUE IN YOUNG CHILDREN.

FATIGUE IN YOUNG CHILDREN.


THE NATURAL HISTORY OF PHENYLKETONURIA.

THE NATURAL HISTORY OF PHENYLKETONURIA.


WHAT TO LOOK FOR IN AIR CONDITIONING EQUIPMENT.


PAUL HARMER SANDIFER.

PAUL HARMER SANDIFER.


STUDY OF TODAY'S CHANGING HOSPITAL ENVIRONMENT SHOWS NEW DIRECTIONS FOR INFECTION CONTROL. A SPECIAL REPORT.


HOSPITAL INDICATORS.

HOSPITAL INDICATORS.


THE OPERATION OF STATE HOSPITAL PLANNING AND LICENSING PROGRAMS.


THE EFFECTS OF SIZE AND SPECIALISM ON UTILIZATION OF URBAN HOSPITALS.


HOSPITAL AND HIGH SCHOOL COLLABORATE IN HEALTH CAREERS PROGRAM.


MINNEAPOLIS FORGES A NEW COMMUNICATION TOOL.


PUERTO RICO'S GIANT STEP TO BETTER HEALTH.


STUDY WILL MEASURE TOTAL IMPACT OF COMPUTERS ON HOSPITAL MANAGEMENT.


HOW AFFILIATION CAN UPGRADE MEDICAL CARE.


THE UNWRITTEN CONTRACT BETWEEN PURCHASING AND ADMINISTRATION.


STATE NUTRITION CONSULTANT GUIDES HOSPITALS IN IMPROVING FOOD SERVICE.


MITRAL STENOSIS: CURRENT SURGICAL MANAGEMENT.


COMMON NEUROLOGIC COMPLAINTS ENCOUNTERED IN GENERAL PRACTICE.


DIAGNOSES MADE IN 10,000 CONSECUTIVE EXCRETORY UROGRAPHIES.


HISTOPLASMOSIS AS A HEALTH PROBLEM IN LOUISIANA.


CLINICAL STUDY OF TOLAZAMIDE: A NEW ANTIDIABETIC SULFONYLUREA.


GENETICS OF ENTAMOEBA: CHARACTERIZATION OF TWO NEW PARASITIC STRAINS WHICH GROW AT ROOM TEMPERATURE (AND AT 37 DEGREES C).


SOME OBSERVATIONS ON THE STRUCTURE OF THE PERISTOMIAL MEMBRANELLE OF SPIROSTOMUM AMBIGUUM.


(THE COMBINED EFFECT OF 3-METHYLCHOLANTHRENE AND N,N'-2,7-FLUORENYLENEBISACETMIDE ON THE INDUCTION OF CANCER OF THE GLANDULAR STOMACH OF THE RAT.)


EFFECT OF NITROFURANS ON THE CHLOROPLAST SYSTEM OF EUGLENA  GRACILIS.


CULTIVATION OF THE PERITRICH TELOTROCHIDIUM HENNEGUYI IN AXENIC AND NON-AXENIC MEDIA.


PERMEABILITY TO SUGARS AND FATTY ACIDS IN POLYTOMA OBTUSUM.


FINE STRUCTURE OF DEVELOPING AND MATURE TRICHOCYSTS IN FRONTONIA VESICULOSA.


EFFECT OF TEMPERATURE ON GROWTH AND NUTRITIONAL REQUIREMENTS OF LEISHMANIA TARENTOLAE IN A DEFINED MEDIUM.


A HYPER-PARASITE OF IODAMOEBA BUETSCHLII FROM THE RHESUS MONKEY, MACACA MULATTA, AND THE DOMESTIC PIG.


NOSEMA MURIS N. SP., A NEW MICROSPORIDIAN PARASITE OF THE WHITE MOUSE (MUS MUSCULUS L.).


ASTHMA AND COUGHING.

ASTHMA AND COUGHING.


THROMBOCYTOPENIA-ETIOLOGY AND TREATMENT.


PREGNANCY, AZOTEMIA AND ICTERUS.

PREGNANCY, AZOTEMIA AND ICTERUS.


EPINEPHRINE ARRHYTHMIAS IN THE DOG HEART-LUNG PREPARATION WITH THE USE OF SEVERAL SENSITIZING AGENTS.


APPLICATION OF EXTERNAL FORCES TO THE HEART.


FACULTY BIOGRAPHY: EDWARD J. LENNON, M.D.


HITLER'S PERSONAL PHYSICIAN.

HITLER'S PERSONAL PHYSICIAN.


HYPERBARIC OXYGENATION.

HYPERBARIC OXYGENATION.


BLOOD VOLUME: METHODOLOGY AND APPLICATIONS.


THE CONGENITALLY MALFORMED. I. THE PROBLEM.


GREASE GUN DAMAGE: SUBCUTANEOUS INJECTION OF PAINT, GREASE, AND OTHER MATERIALS BY PRESSURE GUNS.


THYROIDITIS.

THYROIDITIS.


CARE OF URINARY RETENTION CATHETERS.

CARE OF URINARY RETENTION CATHETERS.


PHENYLKETONURIA: INCIDENCE IN WASHINGTON AND REPORT OF THREE CASES IN ONE FAMILY.


RENAL TUMOR: DIAGNOSTIC AIDS AND PITFALLS.


PULPAL MANAGEMENT OF DECIDUOUS TEETH.

PULPAL MANAGEMENT OF DECIDUOUS TEETH.


RESTORATION OF SEVERELY BROKEN-DOWN TEETH IN CHILDREN.


AN EFFECTIVE DRY SOCKET DRESSING.

AN EFFECTIVE DRY SOCKET DRESSING.


COMPLICATED BILATERAL CLEFT LIP REPAIR. THREE SURGICAL STAGES.


[TENDON SURGERY].

[TENDON SURGERY].


RECENT PATTERNS OF INTERNAL MIGRATION.

RECENT PATTERNS OF INTERNAL MIGRATION.


ACCIDENT HAZARDS ON THE FARM.

ACCIDENT HAZARDS ON THE FARM.


TYPES OF MENTAL DISORDER AMONG RESIDENT PATIENTS.


MULTIPLE CAUSES IN CARDIOVASCULAR-RENAL DISEASES: SEX AND AGE VARIATIONS.


THE EFFECT OF DIRECTION AND SPEED OF IMAGE MOTION UPON TARGET DETECTION WITH SIDE-LOOKING RADAR. TECHN DOCUM REP NO. AMRL-TDR-64-45.


YOUNG'S MODULUS AND BREAKING STRENGTH OF BODY TISSUES. TECHN DOCUM REP NO. AMRL-TDR-64-23.


ERROR CONTROL METHODS FOR AN AUTOMATIC CHECKOUT SYSTEM. TECHN DOCUM REP NO. AMRL-TDR-64-17.


THE EFFECT OF SIMULATED AIRCRAFT SPEED ON DETECTING AND IDENTIFYING TARGETS FROM SIDE-LOOKING-RADAR IMAGERY. TECHN DOCUM REP NO. AMRL-TDR-64-40.


ENDOCRINE AND METABOLIC RESPONSE OF DOGS TO WHOLE-BODY VIBRATION. TECHN DOCUM REP NO. AMRL-TDR-64-54.


A STUDY OF THE EFFECTS OF ANESTHESIA, HIGH OXYGEN AND FEEDING UPON THE RESONANT FREQUENCIES OF VISCERAL ORGANS. TECHN DOCUM REP NO. AMRL-TDR-64-14.


THE EFFECTS OF VIBRATION ON DIAL READING PERFORMANCE. TECHN DOCUM REP NO. AMRL-TDR-64-70.


NOISE SURVEY OF AUXILIARY SUPPORT EQUIPMENT AT ONE ATLAS COMPLEX AND ONE TITAN I COMPLEX, CAPE KENNEDY MISSILE TEST ANNEX, ATLANTIC MISSILE RANGE. TECHN DOCUM REP NO. AMRL-TDR-64-31.


BODY TISSUE CHANGES IN DOGS RESULTING FROM SINUSOIDAL OSCILLATION STRESS. TECHN DOCUM REP NO. AMRL-TDR-64-58.


THE MEASUREMENT OF STIMULUS COMPLEXITY IN HIGH-RESOLUTION SENSOR IMAGERY. TECHN DOCUM REP NO. AMRL-TDR-64-29.


X-20A FULL-PRESSURE SUIT QUANTITATIVE PERFORMANCE. TECHN DOCUM REP NO. AMRL-TDR-64-36.


TWO-MODE THRESHOLD LEARNING. TECHN DOCUM REP NO. AMRL-TDR-64-39.


A STUDY OF THE MECHANISM OF ACUTE TOXIC EFFECTS OF HYDRAZINE, UDMH, MMH, AND SDMH. TECHN DOCUM REP NO. AMRL-TDR-64-26.


STUDY OF HYDROGEN-FIXING MICROORGANISMS FOR CLOSED REGENERATING BIOSYSTEMS. TECHN DOCUM REP NO. AMRL-TDR-64-35.


A BIBLIOGRAPHY OF RUSSIAN SCIENTIFIC AND TECHNOLOGICAL LITERATURE IN MANUAL CONTROL AND ASSOCIATED AREAS. NASA CR-199.


EXPERIMENTAL INVESTIGATIONS ON ULTRA-LOW FREQUENCY DISPLACEMENT BALLISTOCARDIOGRAPHY. NASA TT F-269.


ATTENTION IN TIME DISCRIMINATION AND REACTION TIME. NASA CR-194.


THE EFFECT OF BEDREST ON VARIOUS PARAMETERS OF PHYSIOLOGICAL FUNCTION. I. REVIEW OF THE LITERATURE ON THE PHYSIOLOGICAL EFFECTS OF IMMOBILIZATION. NASA CR-171.


STUDY OF THE THERMAL PROCESSES FOR MAN-IN-SPACE. NASA CR-216.


BIOLOGICAL CONTROL SYSTEMS--A CRITICAL REVIEW AND EVALUATION. DEVELOPMENTS IN MANUAL CONTROL. NASA CR-190.


LABORATORY TESTS OF SUBJECTIVE REACTIONS TO SONIC BOOMS. NASA CR-187.


ESSAYS ON THE HISTORY OF AVIATION MEDICINE. NASA TT F-176.


DEVELOPMENT OF A SELECTION TEST FOR MOTIVATIONAL APTITUDE. NASA CR-156.


A THEORY FOR THE OPTIMAL DETERMINISTIC CHARACTERIZATION OF THE TIME-VARYING DYNAMICS OF THE HUMAN OPERATOR. NASA CR-170.


STUDIES FOR STERILIZATION OF SPACE PROBE COMPONENTS. NASA CR-191.


THE EFFECT OF BEDREST ON VARIOUS PARAMETERS OF PHYSIOLOGICAL FUNCTION. IV. A SYSTEM FOR PROCESSING DATA COLLECTED IN THE IMMOBILIZATION STUDY UNIT. NASA CR-174.


A STUDY OF THE DYNAMIC MODEL TECHNIQUE IN THE ANALYSIS OF HUMAN TOLERANCE TO ACCELERATION. NASA TN D-2645.


RADIATION EXPOSURE IN SOLAR PARTICLE BEAMS BEHIND VERY LOW SHIELDING. RES REP. NSAM-914.


EVALUATION OF AN EXPERIMENTAL  COMBAT CONDITIONING COURSE AND OF PHYSICAL FITNESS TESTS. TASK MR005.01-0030.6.1.


BIOTELEMETRY OF THE TRIAXIAL BALLISTOCARDIOGRAM AND ELECTROCARDIOGRAM IN A WEIGHTLESS ENVIRONMENT. MONOGR NO. 10.


INCREASED INCIDENCE OF MOUSE HEPATOMAS AND OVARIAN ADENOMAS AFTER LOW-DOSE-RATE GAMMA RADIATION. USNRDL-TR-820.


DOSIMETRIC EVALUATION OF THE ALPHA FLUX IN SOLAR PARTICLE BEAMS. RES REP. NSAM-912.


EFFECTS OF BRAIN LESIONS ON ELECTROENCEPHALOGRAPHIC ACTIVATION BY 35 KVP AND 100 KVP X-RAYS. USNRDL-TR-827.


ON THE VALIDITY AND RELIABILITY OF THE AUTONOMIC LABILITY SCORE. REP NO. 64-20.


MOLECULAR PROPERTIES OF CHOLINESTERASES.


DIFFERENTIAL EFFECTS OF HYPOTHALAMIC LESIONS ON PITUITARY-THYROID ACTIVITY IN THE RAT.


PELTIER BIOTHERMODES.

PELTIER BIOTHERMODES.


MINERALIZATION OF DENTAL TISSUES AS MEASURED BY MICRORADIOGRAPHY.


NITROGEN WASHOUT COMPUTER.

NITROGEN WASHOUT COMPUTER.


DYNAMIC BEHAVIOR OF A MATHEMATICAL ANALOG OF THE NORMAL HUMAN ARTERIAL SYSTEM.


GRANULAR DYSTROPHY OF THE CORNEA: AN ELECTRON MICROSCOPIC STUDY.


JUVENILE GLAUCOMA WITH AXENFELD'S SYNDROME: A HISTOLOGIC REPORT.


THE VIBRATION TONOMETER. I. PRINCIPLES AND DESIGN.


THE VIBRATION TONOMETER. II. CLINICAL TESTS.


HEREDITARY EXTERNAL OPHTHALMOPLEGIA.

HEREDITARY EXTERNAL OPHTHALMOPLEGIA.


THE HISTOLOGY OF 6-0 MILD CHROMIC GUT SUTURES IN CATARACT WOUNDS.


OCULAR TENSION IN THE TRENDELENBURG POSITION.


TELEPHONE TRANSMISSION OF ELECTROCARDIOGRAMS ON ON-LINE COMPUTER DIAGNOSIS.


A FOGGING LENS.

A FOGGING LENS.


OCULAR MYOPATHY.

OCULAR MYOPATHY.


RUPTURE OF DISCIFORM MACULAR DEGENERATION CAUSING MASSIVE RETRORETINAL HEMORRHAGE.


INFLUENCE OF OSMOTIC AGENTS ON OUTFLOW RESISTANCE.


EDUCATION IN BIOMEDICAL ENGINEERING.

EDUCATION IN BIOMEDICAL ENGINEERING.


TARSAL GRAFTING TO ELEVATE THE LOWER LID MARGIN.


DIAGNOSTIC AND PROGNOSTIC ROLES OF OPHTHALMONEUROLOGIC SIGNS AND SYMPTOMS IN MALIGNANT NASOPHARYNGEAL TUMORS.


ANTERIOR HYALOID MEMBRANE.

ANTERIOR HYALOID MEMBRANE.


SPECTRAL REFLECTANCE PHOTOGRAPHY OF THE RETINA.


FUNCTIONAL DISORDERS OF CENTRAL VISION.

FUNCTIONAL DISORDERS OF CENTRAL VISION.


CIRCUIT FOR RAPID RETINAL PHOTOGRAPHY.

CIRCUIT FOR RAPID RETINAL PHOTOGRAPHY.


ELECTRONARCOSIS BY A COMBINATION OF DIRECT AND ALTERNATING CURRENT.


STERILIZATION WITH COBALT RADIATION OF FASCIA LATA FOR HOMOTRANSPLANT.


A DANISH PICTORIAL SIGHT-TEST CHART.

A DANISH PICTORIAL SIGHT-TEST CHART.


ENZYMATIC ZONULOLYSIS AS AN AID IN THE EXTRACTION OF SECONDARY CATARACT.


CATARACT EXTRACTION IN FAR-ADVANCED AND ABSOLUTE GLAUCOMA.


TOXOPLASMIC COATS' RETINITIS. A PARASITOLOGICALLY PROVED CASE.


STROMAL CELL SURVIVAL IN GUINEA-PIG INTERLAMELLAR CORNEAL HOMOGRAFTS.


ELECTROCARDIOGRAM OF THE GOLDEN HAMSTER.


MEDICAL PHYSICS IN EDINBURGH.

MEDICAL PHYSICS IN EDINBURGH.


A HUMAN CORNEA WITH A KERATOPROSTHESIS:  A CASE REPORT AND HISTOPATHOLOGIC STUDY.


BILATERAL CEREBRAL BLINDNESS. REPORT OF A COMPLETELY CURED CASE.


MASSIVE DETACHMENT OF THE CHOROID.

MASSIVE DETACHMENT OF THE CHOROID.


SIMPLE METHOD FOR VIEWING STEREOSCOPIC PHOTOGRAPHS.


MODIFIED CALIPER FOR MEASURING CORNEAL DIAMETER.


BURTON CHANCE, SR., M.D., 1868-1965.

BURTON CHANCE, SR., M.D., 1868-1965.


ORBITAL RHABDOMYOMA.

ORBITAL RHABDOMYOMA.


MYCOTIC KERATITIS.

MYCOTIC KERATITIS.


GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND FALCIPARUM MALARIA.


MAN AGAINST MALARIA.

MAN AGAINST MALARIA.


CHLOROQUINE-RESISTANT STRAIN OF PLASMODIUM FALCIPARUM FROM KHAO MAI KHAEO, THAILAND.


THE TREATMENT OF STRONGYLOIDES AND ENTEROBIUS INFECTIONS WITH THIABENDAZOLE.


THE OOGRAM METHOD FOR THE SCREENING OF DRUGS IN SCHISTOSOMIASIS MANSONI.


HUMAN LEPTOSPIROSIS IN IOWA.

HUMAN LEPTOSPIROSIS IN IOWA.


CLINICAL TRIALS WITH THIABENDAZOLE AGAINST INTESTINAL NEMATODES INFECTING HUMANS.


BLOOD LOSS IN PURE ANCYLOSTOMA DUODENALE INFECTION IN EGYPTIAN FARMERS.


STUDIES OF DIARRHEAL DISEASE IN CENTRAL AMERICA. VI. AN EPIDEMIC OF DIARRHEA IN A GUATEMALAN HIGHLAND VILLAGE, WITH A COMPONENT  DUE TO SHIGELLA DYSENTERIAE, TYPE 1.


TYPHOID AND PARATYPHOID FEVERS IN PANJAB (INDIA): A STUDY OF 340 CASES.


HISTOPLASMA CAPSULATUM IN FECAL CONTENTS AND ORGANS OF BATS IN THE CANAL ZONE.


TWO EPISODES OF DENGUE FEVER, CAUSED BY TYPES 4 AND 1 VIRUSES, IN AN INDIVIDUAL PREVIOUSLY IMMUNIZED AGAINST YELLOW FEVER.


OUTBREAK OF POLIOMYELITIS IN CEYLON IN 1962.


ISOLATION OF A CALIFORNIA GROUP ARBOVIRUS FROM FLORIDA MOSQUITOES.


ISOLATION OF A STRAIN OF PASTEURELLA PSEUDOTUBERCULOSIS FROM ALASKA IDENTIFIED AS PASTEURELLA PESTIS: AN IMMUNOFLUORESCENT FALSE POSITIVE.


LABORATORY STUDIES ON THE REPOSITORY ANTIMALARIAL ACTIVITY OF 4,4'-DIACETYLAMINODIPHENYLSULFONE, ALONE AND MIXED WITH CYCLOGUANIL PAMOATE (CI-501).


DIARRHEA CAUSED BY NON-CHOLERA VIBRIOS.

DIARRHEA CAUSED BY NON-CHOLERA VIBRIOS.


CALIFORNIA ENCEPHALITIS VIRUS INFECTION: A CASE REPORT.


EASTERN EQUINE ENCEPHALITIS: REPORT OF A CASE WITH AUTOPSY.


INVESTIGATIONS DURING VENEZUELAN EQUINE ENCEPHALITIS OUTBREAKS IN VENEZUELA--1962-1964.


TWO HUMAN CASES OF LABORATORY INFECTION WITH MUCAMBO VIRUS.


GAS CHROMATOGRAPHIC STUDIES OF VITAMINS D 2 AND D 3.


STUDIES OF ACETYLATED CORTICOSTEROIDS AND RELATED 20-OXOPREGNANE DERIVATIVES BY GAS LIQUID CHROMATOGRAPHY.


X-RAY FLUORESCENCE DETERMINATION OF STRONTIUM IN BIOLOGIC MATERIALS BY DIRECT MATRIX-TRANSMITTANCE CORRECTION.


SPECTROPHOTOMETRIC DETERMINATION OF CALCIUM AND MAGNESIUM IN BLOOD SERUM WITH ARESENAZO AND EGTA.


COLORIMETRIC QUANTITATIVE METHOD FOR DETERMINING GLYCINE IN PRESENCE OF OTHER AMINO ACIDS.


SINGLE EXTRACTION METHOD FOR THE SIMULTANEOUS FLUOROMETRIC DETERMINATION OF SEROTONIN, DOPAMINE, AND NOREPINEPHRINE IN BRAIN.


IMPROVED METHOD FOR MICROTITRATION OF FATTY ACIDS.


SUDDEN DEATH IN INFANCY CAUSED BY IDIOPATHIC ARTERIAL CALCIFICATION.


CONGENITAL COMPLETE HEART BLOCK. II. HISTOLOGY OF THE CONDUCTION SYSTEM.


INTRACRANIAL HEMORRHAGES AND ASSOCIATED DISEASES IN PREMATURE INFANTS.


MICROPOROUS MEMBRANE TECHNOLOGY. I. HISTORICAL DEVELOPMENT AND APPLICATIONS.


PHYSICAL WORKING CAPACITY OF NORMAL AND DIABETIC CHILDREN.


ENURETIC CHILDREN TREATED WITH IMIPRAMINE (TOFRANIL): A CYSTOMETRIC STUDY.


CONGENITAL DIAPHRAGMATIC HERNIA: OPERATION ON VITAL INDICATIONS IN THE NEWBORN.


IN VITRO SECONDARY 19S AND 7S ANTIBODY RESPONSES TO POLIOVIRUS IN MEMBRANE CULTURES OF SEPARATED SPLEEN CELLS.


RABIES VACCINE DERIVED FROM SUCKLING RABBIT BRAIN.


MOLECULAR PROPERTIES OF POLIOVIRUS NEUTRALIZING ANTIBODIES IN HUMAN COLOSTRUM AND MILK.


THE NATURE OF MEASLES VIRUS.

THE NATURE OF MEASLES VIRUS.


NYANDO VIRUS: A HITHERTO UNDESCRIBED VIRUS ISOLATED FROM ANOPHELES FUNESTUS GILES COLLECTED IN KENYA.


ALTERATIONS IN NUCLEIC ACID METABOLISM INDUCED BY INFECTION WITH AN ONCOGENIC VIRUS.


EXTRACTION OF CELL-ASSOCIATED VIRUS WITHOUT DAMAGE OF THE CULTURE. (BRIEF REPORT).


NEUTRALIZING AND FLUORESCENT ANTIBODY RESPONSE IN MAN AFTER ANTIRABIES TREATMENT WITH SUCKLING RABBIT BRAIN VACCINE.


THE SIGNIFICANCE OF VIRAL STRUCTURE.

THE SIGNIFICANCE OF VIRAL STRUCTURE.


EFFECT OF MANGANESE ADMINISTERED WITH IRON IN EXPERIMENTAL ANEMIA IN RATS. SECOND REPORT.


INTERRELATIONSHIPS OF ERYTHROCYTE CHARACTERS AND OTHER CHARACTERS OF BRITISH AND ZEBU CROSSBRED BEEF CATTLE.


FURTHER STUDIES OF THE METABOLISM OF CYSTINE IN SHEEP.


THE MULTIPLE FORMS OF OVINE LACTATE DEHYDROGENASE.


THE ULTRACENTRIFUGATION OF DOUGHS MADE FROM WHEAT FLOUR.


THE FRACTIONATION OF BETA-HISTONE FROM CHICKEN ERYTHROCYTE NUCLEI.


AN IMPROVED CHROMATOGRAPHIC SEPARATION OF WHEAT GLUTEN PROTEINS.


THE EFFECTS OF ACUTE EXPOSURE TO HIGH TEMPERATURES ON PRENATAL DEVELOPMENT IN THE MOUSE WITH PARTICULAR REFERENCE TO SECONDARY VIBRISSAE.


ADAPTIVE ASPECTS OF BEEF CATTLE PRODUCTION.


THE EFFECT OF THE OESTROUS CYCLE AND OF OESTRADIOL ON THE BREAKDOWN OF SEMINAL GLYCERYLPHOSPHORYLCHOLINE BY SECRETIONS OF THE RAT UTERUS.


A DISEASE OF CATTLE IN SOUTH AUSTRALIA RESEMBLING ST. GEORGE DISEASE. I. FIELD INVESTIGATION.


A DISEASE OF CATTLE IN SOUTH AUSTRALIA RESEMBLING ST. GEORGE DISEASE. II. LABORATORY INVESTIGATION.


FINISHING CATTLE ON HIGH-GRAIN RATIONS.

FINISHING CATTLE ON HIGH-GRAIN RATIONS.


ANTIBIOTICS IN VETERINARY PRACTICE.

ANTIBIOTICS IN VETERINARY PRACTICE.


PROGRAMMES OF DISEASE CONTROL IN THOROUGHBRED STUDS.


USE AND ABUSE OF ANTIBIOTICS.

USE AND ABUSE OF ANTIBIOTICS.


ASPECTS OF LEGISLATIVE CONTROL OF ANTIBIOTICS.


EFFECTS OF ALTERED HORMONAL STATES AND FASTING ON RAT-LIVER MITOCHONDRIAL PHOSPHOENOLOPYRUVATE CARBOXYKINASE LEVELS.


LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE.


URINARY PRODUCTS FROM QUERCETIN IN NEOMYCIN-TREATED RATS.


PURIFICATION AND PROPERTIES OF LYSOSTAPHIN--A LYTIC AGENT FOR STAPHYLOCOCCUS AUREUS.


FURTHER PURIFICATION OF A PROTEASE INHIBITOR FROM RABBIT SKIN WITH HEALING INFLAMMATION.


MANAGEMENT ASPECTS OF BEEF CATTLE PRODUCTION.


ATYPICAL SOLUBLE HAEM PROTEINS FROM A STRAIN OF RHODOPSEUDOMONAS PALUSTRIS SP.


THE FATE OF ARGININE PRIOR TO SPOROGENESIS IN SYNCHRONIZED ORDINARY COLORLESS CELLS OF BLASTOCLADIELLA EMERSONII.


THE PROTEIN COMPONENTS OF ELASTOIDIN.

THE PROTEIN COMPONENTS OF ELASTOIDIN.


CARBOHYDRATE TRANSPORT IN STAPHYLOCOCCUS AUREUS I. GENETIC AND BIOCHEMICAL ANALYSIS OF A PLEIOTROPIC TRANSPORT MUTANT.


CONCENTRATION OF TRITIUM IN BRAIN TISSUE OF DOGS GIVEN (I,2-3H-2)CORTISOL INTRAVENOUSLY.


THE FLAVIN COMPOSITION IN SUBFRACTIONS OF PIG- AND BEEF-HEART-MUSCLE PREPARATIONS.


STUDIES ON THE FORMATION OF NITROGENOUS GAS FROM HYDROXYLAMINE BY NITROSOMONAS.


METABOLISM OF (14 C-6)GLUCOSE IN PERFUSED HEARTS OF ALLOXAN-DIABETIC RATS.


STUDIES ON THE METABOLISM IN VIVO OF L-THREONINE O-(35 S)SULPHATE IN THE RAT.


EFFECT OF INSULIN ON THE LEVELS OF OXIDIZED AND REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDES IN THE PERFUSED RAT HEART.


GLUTATHIONE-INSULIN TRANSHYDROGENASE ACTIVITY IN PANCREATIC ISLETS.


PROPERTIES AND PHOTOCHEMICAL DECOMPOSITION OF SOME HYDROXYALKYL DERIVATIVES OF COBALAMIN.


INTERRELATIONSHIPS BETWEEN BIOTIN AND FOLIC ACID. THE DISTRIBUTION OF FOLIC ACID-ACTIVE SUBSTANCES IN THE LIVER OF BIOTIN-DEFICIENT RATS.


THE AMPEROMETRIC TITRATION OF TOTAL AND INTER-CHAIN DISULFIDE BONDS IN GAMMA-GLOBULIN.


THE ANTIGENICITY OF SYNTHETIC POLYPEPTIDES IN PRIMATES.


THE ENHANCED SOLUBILITY OF COLLAGEN FOLLOWING ALKALINE TREATMENT.


INFLUENCE OF CHELATING AGENTS ON THE BIOSYNTHESIS OF COLLAGEN.


STRUCTURE STUDY OF A BENCE-JONES PROTEIN.


FRACTIONATION OF THE KAPPA- AND BETA-CHAINS OF COLLAGEN BY SEPHADEX GEL FILTRATION.


THE AMINO ACID COMPOSITION OF DOG-HEART MYOSIN.


DETERMINATION OF H3 IN SUBSTANCES CONTAINING A LARGE AMOUNT OF I-131-ACTIVITY.


THE CATABOLISM IN VITRO OF CHOLESTEROL: FORMATION OF THE 7-EPIMERIC HYDROXYCHOLESTEROLS FROM CHOLESTEROL IN RAT LIVER.


THE APPARENT HIGH REACTIVITY OF SOME AMINO GROUPS OF NATIVE HEMOGLOBIN.


IDENTIFICATION OF D(-)-BETA-AMINOISOBUTYRIC ACID IN HUMAN LIVER.


ENZYMIC HYDRATION OF ETHYLFUMARYL-COA BY PSEUDOMONAS AERUGINOSA.


ENDOCRINE INVOLVEMENT IN THE SUPPRESSION OF NAD SYNTHESIS PRODUCED BY HYPERPHYSIOLOGICAL LEVELS OF STEROID HORMONES.


ON THE OXIDATION OF RHO-AMINOBENZOATE TO RHO-NITROBENZOATE BYSTREPTOMYCES THIOLUTEUS.


STUDIES ON THE MODE OF ACTION OF ETAMYCIN (VIRIDOGRISEIN).


EVIDENCE FOR PARTICIPATION OF A PHOSPHORYLATED DERIVATIVE OF STREPTIDINE IN STREPTOMYCIN BIOSYNTHESIS.


ENZYMIC LESIONS OF NICOTINAMIDE-ADENINE DINUCLEOTIDE BIOSYNTHESIS IN HEPATOMAS.


FAT METABOLISM IN HIGHER PLANTS. XXI. BIOSYNTHESIS OF FATTY ACIDS BY AVOCADO MESOCARP ENZYME SYSTEMS.


THE CONVERSION OF STEARIC ACID TO OLEIC IN FRESHLY SECRETED MILK.


RAPID CHARCOAL ASSAY FOR INTRINSIC FACTOR (IF), GASTRIC JUICE UNSATURATED B12 BINDING CAPACITY, ANTIBODY TO IF, AND SERUM  UNSATURATED B12 BINDING CAPACITY.


THE EFFECT OF TWO DIETS ON THE GROWTH, REPRODUCTION AND ULTIMATE SIZE OF GUINEA-PIGS.


A LEISHMANIN SURVEY IN SOUTH-EAST TURKEY.


DIABETES AND THE GYNECOLOGIST.

DIABETES AND THE GYNECOLOGIST. The concept of a metabolic disorder of carbohydrate tolerance that progresses with age is examined. It is considered that acute exacerbations may occur at the time of puberty or during pregnancy or the menopause, leading to the development of manifest clinical diabetes.Pregnancy offers a unique opportunity for early diagnosis of potential diabetes in the mother. Existing screening tests are not satisfactory or reliable in uncovering this inborn error of metabolism that may lead to stillbirth or a grossly overweight baby, the onset of clinical diabetes in the mother occurring only many years later.Evidence is presented concerning four conditions that may cause maternal and fetal hyperinsulinism (the primary cause of fetal macrosomia). Also reported is the finding that approximately 50% of apparently normal women over the age of 50 show impaired glucose tolerance.


A CERVICAL CYTOLOGY PROGRAM IN GENERAL PRACTICE. In a six-year period 723 women were examined using cervical cytology smears. Fifteen cancers of the cervix were discovered, including two invasive growths and 13 carcinoma in situ. A careful follow-up was carried out, and the later appearance of cancer was noted in 12 of 41 patients who initially showed only atypical cells. It is recommended that all patients showing "positive" cells (atypical, suspicious, or cancer morphology cells) undergo cone biopsy for definitive histological diagnosis. Target lesions should have punch biopsy. Four cancers were found in 170 obstetrical patients, and it is recommended that this proved high-risk group be screened both prenatally and postnatally. The importance of annual screening of all women over 20 years of age for cancer of the cervix by cytological methods is emphasized.


THE EMOTIONAL RESPONSES OF MARRIED WOMEN RECEIVING ORAL CONTRACEPTIVES. One hundred women taking oral contraceptives were questioned concerning their opinions about personal and sociological effects of this method of conception control. Fifty-three per cent reported improved coital satisfaction while 4% noted the opposite effect. Libido was increased in 22% and decreased in 13%. One woman in five believed that an increase in premarital and extramarital sexual activity would take place in the general population as a result of tablet-induced infertility. The problem of population control is discussed. It is paradoxical that the incidence of unplanned pregnancies continues to increase despite the availability of completely reliable conception control. This reflects present inability to communicate contraceptive knowledge to the appropriate people.


ADEQUATE EXAMINATION OF THE EYE.

ADEQUATE EXAMINATION OF THE EYE. A concise outline of the methodology of an adequate examination of the eye is presented so that the ocular findings may be used properly in establishing a diagnosis. An accurate ocular history is important. Visual acuity at a distance and at the reading point should be measured in such a way as to avoid the introduction of error. A pinhole disc can be used to differentiate a refractive error from organic pathology. Clinical methods of performing the visual field examination, estimating the lacrimal tear production, and determining intraocular pressure are described and illustrated.


LOCALIZED GIANT HYPERTROPHY OF THE GASTRIC MUCOSA WITH MULTIPLE POLYPOSIS (M'ENETRIER'S DISEASE).


NEONATAL HEMATOCOLPOS.

NEONATAL HEMATOCOLPOS.


IRON THERAPY.

IRON THERAPY.


MEDICAL JOURNALISM. 8. BOILING IT DOWN.

MEDICAL JOURNALISM. 8. BOILING IT DOWN.


THE AMBIENT SEWER.

THE AMBIENT SEWER.


THE CAROTID BODY: A PATHOLOGIST'S VIEW.

THE CAROTID BODY: A PATHOLOGIST'S VIEW. A review of the literature on the histogenesis and function of the carotid body suggests that the results and the original interpretations of embryological, histological and histochemical investigations have not provided a convincing explanation of the origin of this structure. That the carotid body is developed from mesoderm and is a sensory organ (chemoreceptor) seems unlikely because of: morphological similarities between some of the carotid body tumours and certain tumours of peripheral nerves; certain electron microscopic similarities between the cells of carotid body and adrenal medulla; chromatographic demonstration of catecholamines in the human carotid bodies; and contradictory results of both animal experiments and clinical observations concerning function of this structure.It is concluded that the carotid body arises from ectoderm and should probably be classified as a gland of internal secretion, related to the adrenal medulla and other paraganglia.


RUPTURED CONGENITAL ANEURYSM OF THE SINUS OF VALSALVA.


THE USE OF POWDERED GOLD IN DENTISTRY. 2.


PULMONARY EMBOLISM AND INFARCTION.

PULMONARY EMBOLISM AND INFARCTION.


THE PROGNOSTIC VALUE OF PREOPERATIVE EVALUATION OF PATIENTS UNDERGOING THORACIC SURGERY.


DIAGNOSTIC PNEUMOMEDIASTINOGRAPHY.

DIAGNOSTIC PNEUMOMEDIASTINOGRAPHY.


CHEST DISEASES IN NURSING HOMES.

CHEST DISEASES IN NURSING HOMES.


THE RELATIONSHIPS BETWEEN MINUTE VENTILATION, PULMONARY GAS DIFFUSION AND RESPIRATORY WORK MEASURED SIMULTANEOUSLY DURING A STANDARD EXERCISE TEST.


SURFACE TENSION OF THE LUNG: THE EFFECT OF BRONCHOPULMONARY DENERVATION IN THE DOMESTIC PIG.


THE CLINICAL RECOGNITION OF "SILENT" MITRAL STENOSIS.


CLINICAL OBSERVATIONS REGARDING SLIDING HIATAL HERNIA.


KYPHOTIC VIEW.

KYPHOTIC VIEW.


TRANSSEPTAL LEFT HEART DYNAMICS IN THIRTY-TWO NORMAL SUBJECTS.


TRAUMATIC PNEUMOTHORAX.

TRAUMATIC PNEUMOTHORAX.


ROENTGENOGRAM OF THE MONTH.

ROENTGENOGRAM OF THE MONTH.


EXERCISE TEST AND CORONARY ARTERIOGRAPHY IN MINIMAL ANGINA.


ANGINOID PAIN FROM FUNNEL CHEST DEFORMITY.


PRIMARY MALIGNANT MESOTHELIOMA OF THE PERICARDIUM: REPORT OF A CASE.


THE WOLFF-PARKINSON-WHITE SYNDROME AND VENTRICULAR SEPTAL DEFECT. A CASE REPORT OF SUCCESSFUL SURGERY IN AN 18-YEAR-OLD MAN.


UNUSUAL ASPECTS OF INTRACAVITARY TUMORS OF THE HEART: REPORT OF TWO CASES.


SCHWANNOMA OF THE NASAL COLUMELLA.

SCHWANNOMA OF THE NASAL COLUMELLA.


THE RELATION OF SKINFOLD THICKNESS IN THE NEONATE TO SEX, LENGTH OF GESTATION, SIZE AT BIRTH AND MATERNAL SKINFOLD.


COMPARATIVE SEROLOGIC REACTIVITY OF I-131 AND I-125 LABELLED HUMAN SERUM ALBUMIN PREPARATIONS.


2-DECAPRENYLPHENOL, BIOSYNTHETIC PRECURSOR OF UBIQUINONE-10.


IRON RETENTION AND HAM DISCOLORATION: A COMPARISON OF FIVE INJECTABLE IRON PREPARATIONS.


THE SPECIFIC-PATHOGEN-FREE PROGRAM TODAY.


ECOLOGY OF NASAL STAPHYLOCOCCI.

ECOLOGY OF NASAL STAPHYLOCOCCI. Davis, Nour A. (University of Lagos Medical School, Lagos, Nigeria), and G. H. G. Davis. Ecology of nasal staphylococci. J. Bacteriol. 89:1163-1168. 1965.-The rate of nasal carriage of Staphylococcus aureus in Nigerian adults (46%) approximates that found in other countries. The rate in infants under 12 months was ca. 70%, which exceeds that found elsewhere, e.g., England. The incidence of penicillin resistance in nasal staphylococci (50 to 60%) is about the same as has been found in strains isolated from infections in outpatients in urban centers in this country. Mannitol-polymyxin agar was used for the selection and differentiation of coagulase-positive staphylococci and proved to be valuable in such studies. Our results clearly show that the degree of colonization by S. aureus significantly influences, or is influenced by, the rate of incidence of other bacteria in the vestibular flora, particularly in the case of diphtheroids and coagulase-negative cocci. The relationship between the degree of nasal microbial colonization and social and other factors is discussed.


VITAMIN REQUIREMENTS OF SEVERAL CELLULOLYTIC RUMEN BACTERIA. Scott, H. W. (Ohio Agricultural Experiment Station, Wooster), and B. A. Dehority. Vitamin requirements of several cellulolytic rumen bacteria. J. Bacteriol. 89:1169-1175. 1965.-Four strains of cellulolytic bacteria recently isolated from in vitro rumen fermentations were used in this study. Nine water-soluble vitamins were tested in single-deletion and single-addition plus biotin experiments, each with and without charcoal-extracted casein hydrolysate. Bacteroides succinogenes A3C and B21a required only biotin under the above experimental conditions. Ruminococcus flavefaciens B34b showed an absolute requirement for biotin and was stimulated by p-aminobenzoic acid (PABA) in the single-deletion experiments. In the single-addition plus biotin experiments, PABA and, to a lesser extent, vitamin B(12) appeared to be required for maximal growth. The presence or absence of casein hydrolysate did not affect the vitamin requirements for the aforementioned three strains. In the single-deletion experiments, R. flavefaciens Cla showed an absolute requirement for biotin and, when casein hydrolysate was omitted, for B(12). When casein hydrolysate was present, no requirement for B(12) could be observed. In the single-addition experiments where the basal medium contained biotin and casein hydrolysate or B(12), PABA was required for maximal growth; however, the single deletion of PABA caused only slight retardation of growth. Investigation of the B(12) or casein hydrolysate requirement of Cla revealed that a mixture of purified amino acids simulating casein hydrolysate satisfied this requirement. Subsequent work indicated that this requirement could be satisfied by the amino acid methionine.


KINETICS OF SPORE GERMINATION.

KINETICS OF SPORE GERMINATION. McCormick, Neil G. (University of Virginia, Charlottesville). Kinetics of spore germination. J. Bacteriol. 89:1180-1185. 1965.-An empirically derived equation was developed which accurately describes the time-course of the decrease in optical density during spore germination. A method is described for calculating the final value, the inflection point, and the maximal velocity from knowledge of three experimental values and the initial value at time-zero. A number of germination curves were analyzed by application of the equation, and the effects of various environmental conditions on the parameters of the equation (k, c, and alpha) are noted. The constant c was found to be dependent upon the temperature and perhaps upon the degree of heat activation and the l-alanine concentration. The constants k and alpha appear to be more basic functions of the initial state of the spore suspension. Variation of the concentration of spores changes only the initial optical density, but does not change any of the three constants.


MECHANISM OF TRYPTIC ACTIVATION OF CLOSTRIDIUM BOTULINUM TYPE E TOXIN. Gerwing, Julia (University of British Columbia, Vancouver, B.C., Canada), Claude E. Dolman, and Arthur Ko. Mechanism of tryptic activation of Clostridium botulinum type E toxin. J. Bacteriol. 89:1176-1179. 1965.-The toxic peptide of trypsin activated Clostridium botulinum type E toxin was purified by chromatography through columns packed with Sephadex G-75 and G-50. The molecular weight of the active peptide was estimated to lie between 10,000 and 12,000. Amino acid analyses indicated that the active peptide had lost at least 18 of the amino acid residues present in the original protein. The active peptide and the original protein were found to have different N-terminal amino acid residues. The mechanism of tryptic activation apparently involves chiefly the removal of amino acids from the N-terminus of the toxin molecule.


SPECTROPHOTOMETRIC CHARACTERIZATION OF PIGMENTS PRODUCED BY STAPHYLOCOCCUS EPIDERMIDIS STRAINS ISOLATED FROM BOVINE UDDERS. Sandvik, Olav (National Animal Disease Laboratory, Ames, Iowa), and Richard W. Brown. Spectrophotometric characterization of pigments produced by Staphylococcus epidermidis strains isolated from bovine udders. J. Bacteriol. 89:1201-1208. 1965.-Spectrophotometric analysis of methanol-extracted pigments of 70 isolates, representing 48 strains of Staphylococcus epidermidis, exhibited absorption curves that were classified into seven types, designated I, II, III, IV, V, VI, and a S. aureus type. Two subtypes were included in types I and III. All nonpigmented cell extracts were classified as type I. One of the six numbered type absorption curves was obtained with the majority of isolates. Three isolates gave an absorption curve that was similar to the curve produced by extracts of five of seven S. aureus strains, thus the designation S. aureus type. The differences in pigment complexes indicated by the various absorption curves of methanol extracts were substantiated by column-chromatography studies. Generally, pigments of types II to VI, as produced by representative strains, were of a xanthophyllic nature, whereas, the S. aureus type pigment studied was carotenelike. Analyses of representative strains showed that the type of spectral absorption curves did not change whether the organisms were carried in vitro and tested through 3 months, or isolated repeatedly from infected udders for periods up to 8 months. The method of determining the spectral absorption curves of whole-cell methanol extracts provides an additional tool for differentiating strains of S. epidermidis that can be used in enzootiological studies of udder infections.


MAJOR PRODUCTS OF GLUCOSE DISSIMILATION BY PSEUDOMONAS NATRIEGENS. Eagon, R. G. (University of Georgia, Athens), and H. W. Cho. Major products of glucose dissimilation by Pseudomonas natriegens. J. Bacteriol. 89:1209-1211. 1965.-Pseudomonas natriegens aerobically catabolized glucose to yield predominantly acetic acid, pyruvic acid, and CO(2), whereas little or no lactic acid was formed. Under anaerobic conditions, glucose in an enriched medium was fermented to yield acetic acid and lactic acid but no pyruvic acid or CO(2). Glucose in a basal salts medium was fermented to yield predominantly acetic acid, lactic acid, and CO(2), while small amounts of pyruvic acid were detected. It was suggested that the aerobic accumulation of acidic products results from rapid glucose dissimilation to the oxidation level of pyruvic acid, followed by a less rapidly functioning tricarboxylic acid cycle.


INFLUENCE OF AERATION AND OF PANTOTHENATE ON GROWTH YIELDS OF ZYMOMONAS MOBILIS. Belaïch, Jean-Pierre (Centre National de la Recherche Scientifique, Marseille, France), and Jacques C. Senez. Influence of aeration and of pantothenate on growth yields of Zymomonas mobilis. J. Bacteriol. 89:1195-1200. 1965.-The growth yields and rates of Zymomonas mobilis were measured in aerobic and anaerobic cultures on glucose medium containing yeast extract, amino acids, or ammonium chloride as the nitrogen source. In the absence of yeast extract, pantothenate was required. The growth yield and rate of the cultures in synthetic (amino acids) or minimal (NH(4)Cl) medium supplemented with pantothenate corresponded only to about one-half the "normal" values obtained in the presence of yeast extract, suggesting a situation of energetically uncoupled growth. Attempts to restore normal growth by the addition of various compounds were unsuccessful. Aeration of the cultures resulted in a partial oxidation of ethyl alcohol to acetate, but did not modify the growth yield nor the division time. Both aerobic and anaerobic cells, however, contained cytochrome c and a cytochrome oxidase of the a(2) type, which was completely inhibited by 10(-4)m cyanide. In anaerobically grown cells, an additional cytochrome of the b type was present. The absence of a Pasteur effect suggests that the transfer of electrons by the respiratory chain of Z. mobilis may not be coupled with oxidative phosphorylation. Aeration had no effect on the catalase content of the cells. As shown by C(14)-glucose incorporation, 2 to 3% of the glucose metabolized was assimilated by the cells in both synthetic and rich complex medium. No intracellular glycogen nor poly-beta-hydroxybutyrate was accumulated when growth was limited by nitrogen or by phosphate in the presence of excess glucose.


PREPARATION AND PROPERTIES OF A VI ANTIGEN-DEGRADING ENZYME. Baker, Edgar E. (Boston University School of Medicine, Boston, Mass.), and Roberta E. Whiteside. Preparation and properties of a Vi antigen-degrading enzyme. J. Bacteriol. 89:1217-1224. 1965.-Vi antigen can be hydrolyzed by an inducible enzyme produced by a microorganism isolated from soil. The organism can be identified as Bacillus sphaericus. The enzyme in the culture supernatant fluid can be concentrated and partially purified by precipitation with ammonium sulfate at 50% of saturation. The partially purified enzyme is relatively stable. Incubation of the enzyme with Vi antigen causes a rapid loss of serological activity, a decrease in viscosity, the loss of ability to precipitate albumin at pH 4.0, and the production of reducing sugar and hexosamine. Optimal conditions for enzyme action on Vi antigen are pH 8.4 and 40 C. The reaction rate is independent of the substrate concentration. Intact protein and calcium activates the Vi antigen-enzyme system. The enzyme is not inhibited by its reaction products.


GROWTH OF MALE-SPECIFIC BACTERIOPHAGE IN PROTEUS MIRABILIS HARBORING F-GENOTES DERIVED FROM ESCHERICHIA COLI. Horiuchi, Kensuke (Yale University, New Haven, Conn.), and Edward A. Adelberg. Growth of male-specific bacteriophage in Proteus mirabilis harboring F-genotes derived from Escherichia coli. J. Bacteriol. 89:1231-1236. 1965.-Male-specific bacteriophage MS2 was shown to infect and grow in Proteus mirabilis strains which harbor F-genotes derived from Escherichia coli K-12. The burst size was 2,000 to 3,000, which is similar to that in E. coli K-12, whereas the latent period was 45 min, definitely longer than that in E. coli. In spite of the multiplication of MS2 in male P. mirabilis in broth, P. mirabilis strains failed to show plaque formation by MS2 on agar plates; this failure may be related to the low efficiency of phage adsorption. No host-controlled modification of MS2 by P. mirabilis was detected.


OXIDATION OF SECONDARY ALCOHOLS BY EXTRACTS OF A CORYNEBACTERIUM. Rosenberg, Eugene (University of California, Los Angeles), and Paul Holmes. Oxidation of secondary alcohols by extracts of a Corynebacterium. J. Bacteriol. 89:1212-1216. 1965.-A Corynebacterium was isolated from soil by use of the enrichment culture technique. This Corynebacterium oxidized and grew on the chemically synthesized secondary alcohol, 3-tetrahydrofuranol. Extracts of this organism contained at least two different nicotinamide adenine dinucleotide-requiring soluble secondary alcohol dehydrogenases. These enzymes were distinguished by the relative rates at which they oxidized thymidylic acid and 3-tetrahydrofuranol. In addition to their substrate specificity, the two enzymes differed in pH optima and thermal stability. Also, the 3-tetrahydrofuranol dehydrogenase was induced by 3-tetrahydrofuranol, whereas the thymidylic acid dehydrogenase was constitutive.


NORMAL INTESTINAL FLORA OF CATTLE FED HIGH-ROUGHAGE RATIONS. Maki, Leroy R. (University of Wyoming, Laramie), and Kay Picard. Normal intestinal flora of cattle fed high-roughage rations. J. Bacteriol. 89:1244-1249. 1965.-Intestinal bacteria were isolated from 15 cattle. Approximately 600 isolates were studied, and their presence and numbers in the duodenum, ileum, cecum, and colon were noted. Bacteria most frequently isolated from all parts of the intestinal tract included Escherichia coli, Streptococcus bovis, and species of Bacillus. Several groups of gram-positive rods could not be classified according to Bergey's Manual. Direct counts of intestinal contents indicated that 1 to 10% of the bacteria present were recovered.


TURBIDIMETRIC CHANGES ACCOMPANYING THE INTERACTION OF ENDOTOXIN AND THE ALPHA-CHAINS OF HUMAN HEMOGLOBIN. Setlow, Peter (Brandeis University, Waltham, Mass.), Lawrence Levine, and Helen Van Vunakis. Turbidimetric changes accompanying the interaction of endotoxin and the alpha chains of human hemoglobin. J. Bacteriol. 89:1237-1243. 1965.-With the use of a turbidimetric assay, the effects of pH, ionic strength, anions and cations, and varying concentrations of reactants on the interaction of Escherichia coli endotoxin (prepared by the Boivin procedure) with the alpha chain of hemoglobin were studied. The reaction was found to be partially reversible by addition of NaCl or by addition of an excess of either reactant. The characteristics of the reaction indicated that complex formation between two multivalent molecules had taken place. The formation of the complex was inhibited by endotoxin (prepared by the Westphal procedure) and by the products which resulted from partial tryptic digestion of alpha chain.


ENZYMATIC BASIS FOR D-ARBITOL PRODUCTION BY SACCHAROMYCES ROUXII. Ingram, Jordan M. (Michigan State University, East Lansing), and W. A. Wood. Enzymatic basis for d-arabitol production by Saccharomyces rouxii. J. Bacteriol. 89:1186-1194. 1965.-The enzymatic steps in d-arabitol synthesis by Saccharomyces rouxii were studied. The fermentation of d-glucose-6-C(14) gave rise to d-arabitol labeled at C-5; d-ribose of ribonucleic acid had the same isotope pattern. Crude extracts were able to reduce d-ribulose with reduced nicotinamide adenine dinucleotide phosphate (NADPH(2)) and d-xylulose with reduced nicotinamide adenine dinucleotide (NADH(2)). These extracts also oxidized d-arabitol with nicotinamide adenine dinucleotide phosphate and xylitol with nicotinamide adenine dinucleotide. No reduction of d-ribulose-5-phosphate or d-xylulose-5-phosphate was observed. An enzyme which reduced d-xylulose with NADH(2) was purified 33-fold and characterized as a xylitol (--> d-xylulose) dehydrogenase. Similarly, an enzyme reducing d-ribulose with NADPH(2) was purified 12-fold and characterized as a d-arabitol (--> d-ribulose) dehydrogenase. Alkaline and acid phosphatases were purified 50- and 40-fold, respectively, and their specificities were determined. Only the acid phosphatase had detectable activity on d-ribulose-5-phosphate. The data support the postulate that d-arabitol arises by dephosphorylation of d-ribulose-5-phosphate and reduction of d-ribulose by a NADPH(2)-linked d-arabitol (--> d-ribulose) dehydrogenase.


FATE OF TRANSFORMING DEOXYRIBONUCLEIC ACID IN BACILLUS SUBTILIS. Venema, G. (Hammersmith Hospital, London, England), R. H. Prtichard, and T. Venema-Schröder. Fate of transforming deoxyribonucleic acid in Bacillus subtilis. J. Bacteriol. 89:1250-1255. 1965.-Donor deoxyribonucleic acid (DNA) introduced into competent recipient cells of Bacillus subtilis undergoes a transient loss of its transforming activity shortly after uptake; transforming activity reappears as a function of time of incubation. Soon after introduction of donor DNA into the cells, joint activity of donor and recipient markers is present; this activity also increases as a function of time of incubation. However, donor marker recovery and appearance of recombinant-type activity have different kinetics, suggesting that recovery of activity of donor DNA after the eclipse phase and integration are separate processes, and that recovery precedes integration. The appearance of recombinant-type activity is independent of DNA synthesis. It is suggested that only one strand of the donor DNA is integrated in transformation. It is, therefore, possible that the eclipse is due to a phase in the transformation process during which the donor DNA is single stranded.


FAILURE OF PRETREATMENT WITH GLUCOCORTICOIDS TO MODIFY THE PHAGOCYTIC AND BACTERICIDAL CAPACITY OF HUMAN LEUKOCYTES FOR ENCAPSULATED TYPE I PNEUMOCOCCUS. Allison, Fred, Jr. (University Medical Center, Jackson, Miss.), and Martha H. Adcock. Failure of pretreatment with glucocorticoids to modify the phagocytic and bactericidal capacity of human leukocytes for encapsulated type I pneumococcus. J. Bacteriol. 89:1256-1261. 1965.-The influence of glucocorticoid administration for 4 days upon the bactericidal and phagocytic functions of leukocytes recovered from venous blood of healthy human beings was evaluated within an in vitro system that contained fully virulent, type I pneumococcus. Ingestion of pneumococcus by granulocytes spread upon a suitable surface, followed by thin slide cultures of the preparation, permitted precise quantitation of cellular phagocytic functions. It was found that granulocytes from healthy donors subjected to short-term glucocorticoid treatment ingested and killed pneumococcus as well as did cells obtained before therapy. Human leukocytes obtained after treatment with prednisolone functioned in a suspending medium of high ionic strength as well as did cells harvested before treatment, although the efficiency of both groups was significantly less than when manipulated in autologous serum.


DEGRADATION OF INORGANIC POLYPHOSPHATE IN MUTANTS OF AEROBACTER AEROGENES. Harold, F. M. (National Jewish Hospital, Denver, Colo.), and Ruth L. Harold. Degradation of inorganic polyphosphate in mutants of Aerobacter aerogenes. J. Bacteriol. 89:1262-1270. 1965.-Extracts of Aerobacter aerogenes contained two enzymes capable of degrading polyphosphate, polyphosphatase and polyphosphate kinase. By use of a suicide technique, a mutant (Pn-4) blocked in polyphosphate degradation was isolated; this mutant was found to lack polyphosphatase. The results indicate that polyphosphatase mediates the main pathway of polyphosphate degradation, and, therefore, that polyphosphate does not serve as a microbial phosphagen. A second mutant (Pn-3) exhibited transient accumulation of polyphosphate when cells were transferred to fresh growth medium. This strain was constitutive for elevated levels of polyphosphate kinase, polyphosphatase, and alkaline phosphatase; the transient accumulation of polyphosphate may be due to the shifting ratios of the biosynthetic and degradative enzymes during growth. These mutants were employed in studies on the competitive relationship between polyphosphate and nucleic acids. It was concluded that nucleic acid synthesis inhibits polyphosphate synthesis and also stimulates polyphosphate degradation.


RADIATION RESISTANCE OF SOIL AZOTOBACTER. Vela, Gerard R. (School of Aerospace Medicine, Brooks Air Force Base, Tex.), and Orville Wyss. Radiation resistance of soil Azotobacter. J. Bacteriol. 89:1280-1285. 1965.-Quantitative recovery of Azotobacter from soils subjected to gamma-radiation from a cobalt-60 source showed the soil populations to be much more highly resistant than isolates from such cultures grown on laboratory media. Even in the encysted state, the laboratory populations were reduced 10,000-fold by exposure to 200 kr, whereas the soil populations were not measurably reduced by that dose.


TRANSDUCTION OF STAPHYLOCOCCUS AUREUS TO TETRACYCLINE RESISTANCE IN VIVO. Jarolmen, Howard (Hahnemann Medical College, Philadelphia, Pa.), Amedeo Bondi, and Richard L. Crowell. Transduction of Staphylococcus aureus to tetracycline resistance in vivo. J. Bacteriol. 89:1286-1290. 1965.-Staphylophage 80, propagated on a hospital strain of Staphylococcus aureus 80/81, has been shown to transduce antibiotic resistance markers to a variety of staphylococcal recipient strains in vitro. In an attempt to demonstrate transduction of penicillin and tetracycline resistance in mice, experiments were performed in which mice were injected intravenously with a pathogenic recipient strain, S. aureus N135, and subsequently with transducing phage by the same route. Periodic assays of organs from infected mice revealed that maximal bacterial concentrations were attained in kidneys 6 days after infection, at which time the transducing lysate, containing approximately 5 x 10(10) plaque-forming particles, was introduced. Isolation of tetracycline-resistant transductants from the kidneys of infected animals was facilitated by the therapeutic administration of tetracycline. In contrast, penicillin-resistant transductants, which produced penicillinase, were not found even when penicillin therapy was administered. Results showed that tetracycline-resistant transductants were recovered from as many as 40% of test animals in repeated experiments. Furthermore, in some of these mice the entire staphylococcal population of the kidneys was found to be tetracycline-resistant. Control infected animals which did not receive phage were uniformly negative for tetracycline-resistant staphylococci. The finding that phage levels were low or undetectable at a time when tetracycline-resistant organisms were recovered from test animals provided evidence that transduction had occurred in vivo.


RESIDUAL ACTIVITY OF THERMALLY DENATURED TRANSFORMING DEOXYRIBONUCLEIC ACID FROM HAEMOPHILUS INFLUENZAE. Barnhart, Benjamin J. (Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md.). Residual activity of thermally denatured transforming deoxyribonucleic acid from Haemophilus influenzae. J. Bacteriol. 89:1271-1279. 1965.-The level of residual transforming activity of heated deoxyribonucleic acid (DNA) (i.e., 1 to a few per cent of native DNA-transforming activity) was found to be independent of the heating and quenching temperatures and less susceptible than native or renatured DNA to heat inactivation upon prolonged heating above or below the critical melting temperature. Similar dose-response curves were obtained for inactivation by formamide of native and renatured DNA, but the residual-active material was much more resistant. Heating DNA above the T(m) in the presence of 1% formaldehyde resulted in a level of residual activity 4 logs lower than that obtained without formaldehyde. Residual-active material was not inactivated by Escherichia coli phosphodiesterase, but it was susceptible to snake venom phosphodiesterase. A new genetic marker was induced in heated-quenched DNA but not in purified residual-active material following nitrous acid treatment. Residual activity was found to be less susceptible to ultraviolet inactivation and to band at a higher density region in CsCl than native DNA. In conclusion, it is suggested that the residual-active material is a structure formed by intrastrand hydrogen bonding of the separated units of heated-quenched DNA. Such a configuration would result in at least a partially double-stranded structure, which is probably the essential characteristic of the residual-active material endowing it with biological activity.


IMMUNOGENIC ACTIVITY OF A RIBOSOMAL FRACTION OBTAINED FROM MYCOBACTERIUM TUBERCULOSIS. Youmans, Anne S. (Northwestern University Medical School, Chicago, Ill.), and Guy P. Youmans. Immunogenic activity of a ribosomal fraction obtained from Mycobacterium tuberculosis. J. Bacteriol. 89:1291-1298. 1965.-The highly immunogenic particulate fraction obtained from mechanically ruptured cells of the H37Ra strain of Mycobacterium tuberculosis was suspended and centrifuged at 20,360 x g. The supernatant liquid from this centrifugation was centrifuged at 56,550 x g to remove the larger particles, and the supernatant liquid from this was centrifuged at 144,000 x g to obtain a ribosomal fraction. The sediments from the first two centrifugations were highly immunogenic, but the ribosomal fraction showed only slight capacity to immunize mice. However, when the ribosomal fraction was mixed with Freund's incomplete adjuvant, the immunogenic activity was equivalent to the particulate fraction from which it was prepared. To test the hypothesis that some membranous substance in the particulate fraction was acting as an adjuvant for the smaller particles in the ribosomal fraction, portions of the particulate fraction were treated separately with each of the membrane-disrupting agents, sodium deoxycholate, sodium lauryl sulfate, and 1 m sodium chloride. The treated materials were then centrifuged at 144,000 x g, and the sediments were tested for immunogenicity both with and without the addition of Freund's incomplete adjuvant. Without the adjuvant, the immunizing activities were very weak or absent; with the adjuvant, they were equivalent to that of the particulate fraction from which they were prepared. Other factors which have been found to damage or destroy membranes, such as freezing and thawing, and heat, also significantly decreased the immunogenic activity of the particulate fraction unless it was incorporated into Freund's incomplete adjuvant. The larger particles which sedimented at 56,550 x g were also treated with sodium lauryl sulfate and sodium chloride. Again, immunogenicity was greatly reduced but was fully restored by use of Freund's incomplete adjuvant. The data suggest, then, that the immunizing component of the particulate fraction is a substance (ribosomal?) which sediments at 144,000 x g, but for maximal immunizing activity a labile, possibly membranous, moiety of the mycobacterial cell, which has the properties of an adjuvant, is required.


EFFECT OF ETHAMBUTOL ON NUCLEIC ACID METABOLISM IN MYCOBACTERIUM SMEGMATIS AND ITS REVERSAL BY POLYAMINES AND DIVALENT CATIONS. Forbes, M. (Lederle Laboratories Division, Pearl River, N.Y.), N. A. Kuck, and E. A. Peets. Effect of ethambutol on nucleic acid metabolism in Mycobacterium smegmatis and its reversal by polyamines and divalent cations. J. Bacteriol. 89:1299-1305. 1965.-Mycobacterium smegmatis, harvested from cultures inhibited by ethambutol and then suspended in drug-free medium, exhibited a prolonged lag before growth resumed. Polyamines and magnesium ions shortened this lag. Polyamines and magnesium added to the culture increased the minimal inhibitory concentration of the drug and reversed the inhibitory effect of the drug, even when added after the drug had already inhibited growth. When ethambutol was added to a culture in its exponential phase of growth, synthesis of protein and deoxyribonucleic acid (DNA), as measured by incorporation of S(35) and P(32), continued for 3 hr at a rate slightly less than in the control cells and then essentially ceased. Synthesis of ribonucleic acid (RNA) was depressed, but it proceeded even after protein synthesis had ceased. Even though the synthesis of RNA continued, the net RNA decreased, and inhibited cells became deficient in RNA. Polyamines and divalent cations, which reverse the inhibitory effect of the drug, have been reported to be involved in nucleic acid turnover. These considerations suggested that ethambutol may exert its inhibitory effect by interfering with a function of cellular polyamines and divalent cations in RNA metabolism.


NONPHOTOREACTIVATING REPAIR OF ULTRAVIOLET LIGHT-DAMAGED MICROCOCCUS LYSODEIKTICUS CELLS. Elder, Robert L. (Johns Hopkins University, Baltimore, Md.), and Roland F. Beers, Jr. Nonphotoreactivating repair of ultraviolet light-damaged Micrococcus lysodeikticus cells. J. Bacteriol. 89:1225-1230. 1965.-Micrococcus lysodeikticus cells are highly resistant to ultraviolet radiation. The shape of the dose-survival curve is consistent with the presence of a repair mechanism. The presence of nontoxic doses of dinitrophenol (0.1 mm) or iodoacetate (1 mm) before or after radiation decreases the survival number and the initial lag in the dose-kill curve. The extent of decrease in survival after postradiation treatment with these compounds is dependent upon both time and temperature. Organisms that survive radiation show a prolonged lag phase before multiplying. No photoreactivation of the radiated cells can be demonstrated. Ultraviolet-radiated phage show a higher inactivation when plated on host cells of M. lysodeikticus treated with dinitrophenol at concentrations which do not affect the infectivity of nonradiated phage. The resistance of these cells to ultraviolet radiation is the result of a very efficient dark-cell repair mechanism that can be blocked by iodoacetate or dinitrophenol.


UNSTABLE LINKAGE BETWEEN GENETIC MARKERS IN TRANSFORMATION. Kelly, M. (Hammersmith Hospital, London, England), and R. H. Pritchard. Unstable linkage between genetic markers in transformation. J. Bacteriol. 89:1314-1321. 1965.-A new type of association of genetic markers in a transformation system has been discovered. Linkage between certain markers is detectable only under particular conditions of deoxyribonucleic acid (DNA) extraction and is sensitive to dilution of the DNA. The data suggest that this unstable association occurs between markers which are on the same molecule but separated by a molecular distance sufficiently great for linkage to be preserved only by mild DNA extraction procedures and at high concentrations of DNA. Linkage can be stabilized by dilution in the presence of a carrier DNA. By use of these unstable linkages, the genetic map of Bacillus subtilis has been extended in both directions from the aromatic gene cluster.