---
title: ADNI Mini v1.2
tags:
- medical-imaging
- mri
- nifti
- alzheimers
- adni
license: other
---

# ADNI Mini v1.2

Longitudinal-rich ADNI sMRI evaluation set for frozen-feature / linear-probe
**prognosis** evaluation (clinical path, cognitive decline, AD-typical atrophy).

- **1,200 subjects / 1,200 scans** (one processed T1w per subject)
- Soft diagnosis balance: **450 CN / 500 MCI / 250 AD**
- Sex: **600 Female / 600 Male**
- Age at scan: 60–90
- Single `eval` split as Hugging Face Arrow shards with embedded NIfTI bytes
- **Brain masks are not included**

## Load

```python
from datasets import load_dataset

ds = load_dataset("medarc/adni-mini-v1-2", split="eval")
print(ds)
# image column: nifti
```

## Primary label coverage (approx.)

| Target | n |
|---|---:|
| ADAS-Cog13 annualized slope (48m) | ~1121 |
| Logical Memory delayed (LDELTOTAL) slope (48m) | ~1031 |
| Hippocampus / lateral ventricle / amygdala slopes (48m) | ~1093 each |
| MCI → AD risk (known at 36m) | ~500 (~186 events) |
| MCI A+ → AD (36m) | ~249 (~101 events) |
| CN A+ → MCI/AD (36m) | ~134 (~23 events) |
| Amyloid centiloid | ~975 |
| Tau meta-temporal SUVR | ~533 |
| CSF Aβ / p-tau / t-tau | ~901 / 899 / 901 |

## Task philosophy

| Primary | Secondary |
|---|---|
| Staging (AD vs CN, CN/MCI/AD) | Molecular: centiloid, tau SUVR, CSF |
| MCI conversion risk 36m | A+ stratified progression |
| ADAS13 + LDEL slopes | Sex (sanity) |
| Hippo / lat. ventricle / amygdala slopes | |
| Age, BAG, SynthSeg volumes | |

### Orientation

- **ADAS13 slope:** higher = worse cognition  
- **LDELTOTAL slope:** more negative = memory decline  
- **Hippocampus / amygdala slopes:** more negative = atrophy (ICV-normalized)  
- **Lateral ventricle slope:** more positive = expansion (L+R lateral only, not 3rd/4th)  

### Design notes

- Optimized for **longitudinal richness** (follow-up, multi-T1, conversion known), not pure 400/400/400 B-equal.
- Continuous cognitive/atrophy rates preferred over coarse ordinal scores (no CDR-SB primary).
- Molecular PET/CSF labels retained as **secondary association** checks (not “virtual PET” headlines).
- One scan per subject; longitudinal labels precomputed onto that baseline row.

## Rebuild (local)

```bash
.venv/bin/python datasets/adni/select_v12.py \
  --output artifacts/adni-mini-v1-2/selected_manifest.csv

.venv/bin/python datasets/adni/build_mini.py \
  --selected-manifest artifacts/adni-mini-v1-2/selected_manifest.csv \
  --output-dir artifacts/adni-mini-v1-2 \
  --fingerprint adni-mini-v1-2-eval-1200
```

See `datasets/adni/v1.2_notes.md` for full design and feasibility notes.