"""Demographic confound & shortcut-baseline analysis (P10, Table 5 part 1). Purpose: show how much of the 3-class signal is recoverable from demographics / morphometry ALONE (no MRI). If an age-only model is already strong, the dataset has confounding that must be discussed honestly rather than hidden. Shortcut baselines: - age-only logistic regression - demographic XGBoost (age, sex, education, ses) - full-structured XGBoost (demographic + eTIV, nWBV, ASF) All evaluated on the SAME subject-level folds/seeds as the main experiments, using out-of-fold predictions so numbers are directly comparable to Table 3. Never uses CDR or MMSE (label leakage). """ from __future__ import annotations from pathlib import Path import numpy as np import pandas as pd from sklearn.linear_model import LogisticRegression from sklearn.preprocessing import StandardScaler from trifuse.data.splits import make_folds, split_for, SEEDS, N_FOLDS from trifuse.eval.metrics import compute_metrics from trifuse.models.baselines_tab import make_xgb DEMO_COLS = ["age", "sex", "education", "ses"] FULL_COLS = ["age", "sex", "education", "ses", "etiv", "nwbv", "asf"] def _oof_predict(df: pd.DataFrame, feature_cols: list[str], model_kind: str) -> pd.DataFrame: """Run repeated CV, return per-subject OOF predictions (one row per subject per seed).""" folds = make_folds(df) records = [] for seed in SEEDS: for fold in range(N_FOLDS): tr_ids, va_ids, te_ids = split_for(folds, df, seed, fold) tr = df[df["subject_id"].isin(set(tr_ids) | set(va_ids))] te = df[df["subject_id"].isin(te_ids)] Xtr = tr[feature_cols].to_numpy(dtype=float) ytr = tr["class_id"].to_numpy(dtype=int) Xte = te[feature_cols].to_numpy(dtype=float) yte = te["class_id"].to_numpy(dtype=int) # impute (train medians) + standardize med = np.nanmedian(Xtr, axis=0) Xtr = np.where(np.isnan(Xtr), med, Xtr) Xte = np.where(np.isnan(Xte), med, Xte) sc = StandardScaler().fit(Xtr) Xtr, Xte = sc.transform(Xtr), sc.transform(Xte) if model_kind == "logreg": clf = LogisticRegression(max_iter=1000, class_weight="balanced") clf.fit(Xtr, ytr) prob = clf.predict_proba(Xte) else: # xgboost clf = make_xgb(n_classes=3, seed=seed) clf.fit(Xtr, ytr) prob = clf.predict_proba(Xte) pred = prob.argmax(1) for sid, yt, yp, pr in zip(te_ids, yte, pred, prob): records.append({"subject_id": sid, "seed": seed, "fold": fold, "y_true": int(yt), "y_pred": int(yp), "p0": pr[0], "p1": pr[1], "p2": pr[2]}) return pd.DataFrame(records) def run_confound(subjects_csv: str | Path, out_dir: str | Path) -> pd.DataFrame: df = pd.read_csv(subjects_csv) df = df[df["class_id"].notna()].reset_index(drop=True) df["class_id"] = df["class_id"].astype(int) out_dir = Path(out_dir); out_dir.mkdir(parents=True, exist_ok=True) configs = [ ("age_only_logreg", ["age"], "logreg"), ("demographic_xgb", DEMO_COLS, "xgboost"), ("full_structured_xgb", FULL_COLS, "xgboost"), ] summary = [] for name, cols, kind in configs: oof = _oof_predict(df, cols, kind) oof.to_csv(out_dir / f"oof_{name}.csv", index=False) # aggregate metric per seed then mean+/-std per_seed = [] for seed in SEEDS: s = oof[oof["seed"] == seed] m = compute_metrics(s["y_true"].to_numpy(), s["y_pred"].to_numpy(), s[["p0", "p1", "p2"]].to_numpy()) per_seed.append(m) macro_f1 = np.array([m["macro_f1"] for m in per_seed]) bal_acc = np.array([m["balanced_accuracy"] for m in per_seed]) ad_recall = np.array([m["recall_AD"] for m in per_seed]) summary.append({ "model": name, "macro_f1_mean": macro_f1.mean(), "macro_f1_std": macro_f1.std(), "bal_acc_mean": bal_acc.mean(), "bal_acc_std": bal_acc.std(), "ad_recall_mean": ad_recall.mean(), "ad_recall_std": ad_recall.std(), }) res = pd.DataFrame(summary) res.to_csv(out_dir / "confound_summary.csv", index=False) return res if __name__ == "__main__": import sys csv = sys.argv[1] if len(sys.argv) > 1 else "data/metadata/subjects_clean.csv" out = sys.argv[2] if len(sys.argv) > 2 else "results/tables/confound" print(run_confound(csv, out).to_string(index=False))