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Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[382,2426],[1815,2426],[1815,2471],[382,2471]],"region":{"top_left_x":382,"top_left_y":2425,"width":1434,"height":46},"line":48,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffe695d328f048678413d41dd5636209","type":"text","conversion_output":true,"text":"If the patency examination for a graft at the visit 9 ( 1 year after CABG ) is missing, then level O","text_display":"\n\nIf the patency examination for a graft at the visit 9 ( 1 year after CABG ) is missing, then level O","confidence":0.9834346531474125,"confidence_rate":0.9998596393764718},{"cnt":[[305,2466],[1405,2466],[1405,2512],[305,2512]],"region":{"top_left_x":305,"top_left_y":2466,"width":1101,"height":46},"line":49,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d7c7a2941d404ef48c8e69dc277be6db","type":"text","conversion_output":true,"text":"will be imputed, then this graft is deemed as occlusion in primary analysis.","text_display":" will be imputed, then this graft is deemed as occlusion in primary analysis.","confidence":1,"confidence_rate":1},{"cnt":[[309,2548],[621,2548],[621,2589],[309,2589]],"region":{"top_left_x":309,"top_left_y":2548,"width":312,"height":41},"line":50,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"11fe787e383843848a5aa785c1932f63","type":"page_info","conversion_output":false,"text":"Version: 4.0 28Aug2017","text_display":"","confidence":0.9171116352081299,"confidence_rate":0.9968004600447463},{"cnt":[[1259,2552],[1298,2552],[1298,2591],[1259,2591]],"region":{"top_left_x":1258,"top_left_y":2552,"width":40,"height":40},"line":51,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"4980e4f250f844a7957a46e4cdfd1228","type":"page_info","conversion_output":false,"text":"11","text_display":"","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0aec4542-8112-41df-bc16-87f7f6320bf6-12","page":12,"lines":[{"cnt":[[305,185],[937,185],[937,238],[305,238]],"region":{"top_left_x":305,"top_left_y":184,"width":632,"height":55},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71aa17de342b446abfdb452115da97e2","type":"text","conversion_output":true,"text":"8．3．2 Statistical Test for Primary Endpoint","text_display":"\n\n8．3．2 Statistical Test for Primary Endpoint","confidence":1,"confidence_rate":1},{"cnt":[[301,245],[1663,245],[1663,318],[301,318]],"region":{"top_left_x":300,"top_left_y":244,"width":1363,"height":74},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"508b626854604c31b0bcaab2aa60ca0d","type":"math","conversion_output":true,"text":"\\[\nH_{0}: P_{T}-P_{A}=0 \\quad H_{1}: P_{T}-P_{A} \\neq 0 \\quad \\text { 与 } H_{0}: P_{T+A}-P_{A}=0 \\quad H_{1}: P_{T+A}-P_{A} \\neq 0\n\\]","text_display":"\n\\[\nH_{0}: P_{T}-P_{A}=0 \\quad H_{1}: P_{T}-P_{A} \\neq 0 \\quad \\text { 与 } H_{0}: P_{T+A}-P_{A}=0 \\quad H_{1}: P_{T+A}-P_{A} \\neq 0\n\\]","confidence":0.96875,"confidence_rate":0.9997716181815551},{"cnt":[[305,314],[1158,314],[1158,363],[305,363]],"region":{"top_left_x":305,"top_left_y":313,"width":854,"height":51},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"dd1ff33aeb6b4ed486beac9db16d46d1","type":"text","conversion_output":true,"text":"A－Aspirin、T－ticagrelor、T＋A－Aspirin＋ticagrelor","text_display":"\n\nA－Aspirin、T－ticagrelor、T＋A－Aspirin＋ticagrelor","confidence":0.9198886083284492,"confidence_rate":0.9983954675989446},{"cnt":[[378,402],[1820,402],[1820,449],[378,449]],"region":{"top_left_x":378,"top_left_y":401,"width":1442,"height":49},"line":5,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5a8bc2e530f04013b74b016e924e2fa5","type":"text","conversion_output":true,"text":"Patency results from all the 3 treatment groups will be modeled in a same Generalized Estimating","text_display":"\nPatency results from all the 3 treatment groups will be modeled in a same Generalized Estimating","confidence":0.99853515625,"confidence_rate":0.9999859047370074},{"cnt":[[305,443],[1820,443],[1820,490],[305,490]],"region":{"top_left_x":305,"top_left_y":442,"width":1515,"height":48},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cfe445a14b0a4b18877aed762db0c2da","type":"text","conversion_output":true,"text":"Equation，the rate difference and its \\(95 \\% CI\\) will be derived for the comparisons of A vs \\(A + T\\)（or A vs","text_display":" Equation，the rate difference and its \\(95 \\% CI\\) will be derived for the comparisons of A vs \\(A + T\\)（or A vs","confidence":0.9907402927055955,"confidence_rate":0.9999295263857697},{"cnt":[[305,486],[1820,486],[1820,535],[305,535]],"region":{"top_left_x":305,"top_left_y":485,"width":1515,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1a629ea4f4344163a62b1b8bd1223367","type":"text","conversion_output":true,"text":"T ）．If the lower of \\(95 \\% CI\\) is greater than 0 ，then \\(A + T\\)（or T ）is statistical significantly higher in the","text_display":" T ）．If the lower of \\(95 \\% CI\\) is greater than 0 ，then \\(A + T\\)（or T ）is statistical significantly higher in the","confidence":0.998535871389322,"confidence_rate":0.9999893051557718},{"cnt":[[305,529],[1160,529],[1160,578],[305,578]],"region":{"top_left_x":305,"top_left_y":528,"width":856,"height":50},"line":8,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0de50661900c493ca7aa2bffa712f0c2","type":"text","conversion_output":true,"text":"patency rate than A ，the superiority of \\(A + T\\)（or T ）proved．","text_display":" patency rate than A ，the superiority of \\(A + T\\)（or T ）proved．","confidence":0.9985356330871582,"confidence_rate":0.9999829601434831},{"cnt":[[301,584],[1033,584],[1033,645],[301,645]],"region":{"top_left_x":300,"top_left_y":584,"width":734,"height":61},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bed2e4052882419b86277d9471a04872","type":"section_header","conversion_output":false,"children_ids":["b372a01d67134799affe63e13c61d63c"],"text":"","text_display":""},{"cnt":[[305,589],[1025,589],[1025,638],[305,638]],"region":{"top_left_x":305,"top_left_y":588,"width":720,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b372a01d67134799affe63e13c61d63c","type":"text","conversion_output":true,"parent_id":"bed2e4052882419b86277d9471a04872","text":"8．3．3 Statistical Descriptive of Patency of Grafts","text_display":"\n\n\\section*{8．3．3 Statistical Descriptive of Patency of Grafts}","confidence":1,"confidence_rate":1},{"cnt":[[378,653],[1818,653],[1818,698],[378,698]],"region":{"top_left_x":378,"top_left_y":653,"width":1440,"height":46},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"93377f47faa14a79a481b2e4044c7537","type":"text","conversion_output":true,"text":"There levels of patency examination in grafts according to the Fitzgibbon Standards，that＇s level","text_display":"\n\nThere levels of patency examination in grafts according to the Fitzgibbon Standards，that＇s level","confidence":1,"confidence_rate":1},{"cnt":[[305,696],[1820,696],[1820,741],[305,741]],"region":{"top_left_x":305,"top_left_y":696,"width":1515,"height":46},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"97b0572a65a04ec292ed559008896a30","type":"text","conversion_output":true,"text":"A，level B，and level O，and it＇s ordinal variable．The patency of grafts at the visit 5 （ 7 days after","text_display":" A，level B，and level O，and it＇s ordinal variable．The patency of grafts at the visit 5 （ 7 days after","confidence":0.9839382171630859,"confidence_rate":0.9998579734960437},{"cnt":[[305,739],[1820,739],[1820,784],[305,784]],"region":{"top_left_x":305,"top_left_y":739,"width":1515,"height":46},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3f602c7fe5494c1f866f0179f14f0d8f","type":"text","conversion_output":true,"text":"CABG）and visit 9 （ 1 year after CABG）will be summarized by using the statistical method for the","text_display":" CABG）and visit 9 （ 1 year after CABG）will be summarized by using the statistical method for the","confidence":0.5430693663656712,"confidence_rate":0.9943630013493363},{"cnt":[[305,780],[556,780],[556,823],[305,823]],"region":{"top_left_x":305,"top_left_y":779,"width":252,"height":44},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"94c72f61804647358d7bdd6f6ac21530","type":"text","conversion_output":true,"text":"ordinal variable．","text_display":" ordinal 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Endpoint}","confidence":1,"confidence_rate":1},{"cnt":[[378,1014],[1820,1014],[1820,1063],[378,1063]],"region":{"top_left_x":378,"top_left_y":1014,"width":1442,"height":50},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"823616d05cc84c40a6bcad852b594c91","type":"text","conversion_output":true,"text":"For the missing values in the patency examination for any graft in any visit will be imputed by","text_display":"\n\nFor the missing values in the patency examination for any graft in any visit will be imputed by","confidence":0.99951171875,"confidence_rate":0.9999951160069457},{"cnt":[[305,1057],[896,1057],[896,1102],[305,1102]],"region":{"top_left_x":305,"top_left_y":1057,"width":591,"height":46},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7890346a62f74c47985167009f4b57b0","type":"text","conversion_output":true,"text":"the worst level in Fitzgibbon Standards．","text_display":" the worst level in Fitzgibbon Standards．","confidence":0.9970703125,"confidence_rate":0.9999348024046826},{"cnt":[[378,1100],[1381,1100],[1381,1145],[378,1145]],"region":{"top_left_x":378,"top_left_y":1100,"width":1004,"height":46},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6ae2239543ed41d8bdc331855bc246e8","type":"text","conversion_output":true,"text":"For the other secondary endpoints，missing value won＇t be imputed．","text_display":"\n\nFor the other secondary endpoints，missing value won＇t be imputed．","confidence":1,"confidence_rate":1},{"cnt":[[301,1156],[1381,1156],[1381,1216],[301,1216]],"region":{"top_left_x":300,"top_left_y":1155,"width":1082,"height":62},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"31cba4c2f2b94902839080b658f2065b","type":"section_header","conversion_output":false,"children_ids":["ffb339decfbc4630af02c8a16a865ce6"],"text":"","text_display":""},{"cnt":[[305,1160],[1377,1160],[1377,1210],[305,1210]],"region":{"top_left_x":305,"top_left_y":1160,"width":1073,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ffb339decfbc4630af02c8a16a865ce6","type":"text","conversion_output":true,"parent_id":"31cba4c2f2b94902839080b658f2065b","text":"8．4．2 Statistical Descriptive and Statistical Test for Secondary Endpoints","text_display":"\n\n\\section*{8．4．2 Statistical Descriptive and Statistical Test for Secondary Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[378,1225],[1820,1225],[1820,1274],[378,1274]],"region":{"top_left_x":378,"top_left_y":1224,"width":1442,"height":51},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a98748951ee9436297b5e46bbd97ef75","type":"text","conversion_output":true,"text":"GEE will be applied to the rate of patency and non－occlusion of grafts，the other secondary","text_display":"\n\nGEE will be applied to the rate of patency and non－occlusion of grafts，the other secondary","confidence":1,"confidence_rate":1},{"cnt":[[305,1268],[1820,1268],[1820,1313],[305,1313]],"region":{"top_left_x":305,"top_left_y":1267,"width":1515,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7d8f4a88e46f48e68436777ec5ee716f","type":"text","conversion_output":true,"text":"endpoints will be analyzed by using the statistical methods defined in chapter 8．2，depends on the","text_display":" endpoints will be analyzed by using the statistical methods defined in chapter 8．2，depends on the","confidence":1,"confidence_rate":1},{"cnt":[[305,1311],[681,1311],[681,1356],[305,1356]],"region":{"top_left_x":305,"top_left_y":1310,"width":377,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"55bdb1caefb64f65b714b79bef894e21","type":"text","conversion_output":true,"text":"property of the variables．","text_display":" property of the variables．","confidence":1,"confidence_rate":1},{"cnt":[[378,1349],[1824,1349],[1824,1396],[378,1396]],"region":{"top_left_x":378,"top_left_y":1349,"width":1447,"height":48},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1023102a57534b18a1ca7ec5584222c1","type":"text","conversion_output":true,"text":"For MACE，statistical methods for the discrete variables will be applied to compare the rates of","text_display":"\n\nFor MACE，statistical methods for the discrete variables will be applied to compare the rates of","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[305,1392],[1820,1392],[1820,1437],[305,1437]],"region":{"top_left_x":305,"top_left_y":1392,"width":1515,"height":46},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6a16c479cdb54b548e70876de69c2eba","type":"text","conversion_output":true,"text":"MACE event among these 3 treatment groups，Time to MACE（measured in days）will be analyzed","text_display":" MACE event among these 3 treatment groups，Time to MACE（measured in days）will be analyzed","confidence":1,"confidence_rate":1},{"cnt":[[305,1435],[1820,1435],[1820,1480],[305,1480]],"region":{"top_left_x":305,"top_left_y":1435,"width":1515,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad92c2b5f73040818186fe13e01d62ff","type":"text","conversion_output":true,"text":"using a log－rank test．Subjects who had not experienced MACE will be right－censored．The survival","text_display":" using a log－rank test．Subjects who had not experienced MACE will be right－censored．The survival","confidence":1,"confidence_rate":1},{"cnt":[[305,1478],[1126,1478],[1126,1523],[305,1523]],"region":{"top_left_x":305,"top_left_y":1478,"width":821,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f0700885d7474d1982c05407a4ee62ca","type":"text","conversion_output":true,"text":"curves will be estimated using Kaplan－Meier estimates．","text_display":" curves will be estimated using Kaplan－Meier 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Endpoints}","confidence":1,"confidence_rate":1},{"cnt":[[301,1684],[634,1684],[634,1742],[301,1742]],"region":{"top_left_x":300,"top_left_y":1684,"width":334,"height":59},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"63e0df35d645428ea235763a987ff114","type":"section_header","conversion_output":false,"children_ids":["bfbf0066719343a6b4f2b8798283d7a3"],"text":"","text_display":""},{"cnt":[[305,1693],[629,1693],[629,1738],[305,1738]],"region":{"top_left_x":305,"top_left_y":1692,"width":325,"height":47},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bfbf0066719343a6b4f2b8798283d7a3","type":"text","conversion_output":true,"parent_id":"63e0df35d645428ea235763a987ff114","text":"8．5．1 Adverse Events","text_display":"\n\n\\section*{8．5．1 Adverse 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Liang, K. Y. and Zeger, S. L. (1986), \"Longitudinal Data Analysis Using Generalized Linear","text_display":"\n[1]. Liang, K. Y. and Zeger, S. L. (1986), \"Longitudinal Data Analysis Using Generalized Linear","confidence":1,"confidence_rate":1},{"cnt":[[305,370],[797,370],[797,415],[305,415]],"region":{"top_left_x":305,"top_left_y":369,"width":493,"height":46},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"73f86ce8bbe64f6cb1644e1780c5900d","type":"text","conversion_output":true,"text":"Models,\" Biometrika, 73, 13-22.","text_display":" Models,\" Biometrika, 73, 13-22.","confidence":1,"confidence_rate":1},{"cnt":[[305,2548],[621,2548],[621,2589],[305,2589]],"region":{"top_left_x":305,"top_left_y":2548,"width":316,"height":41},"line":5,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"d1d88beb3b9549df87f092b295f86bf9","type":"page_info","conversion_output":false,"text":"Version: 4.0 28Aug2017","text_display":"","confidence":0.9946331977844238,"confidence_rate":0.9998007141107096},{"cnt":[[1255,2548],[1298,2548],[1298,2585],[1255,2585]],"region":{"top_left_x":1254,"top_left_y":2548,"width":44,"height":37},"line":6,"column":0,"font_size":22,"is_printed":true,"is_handwritten":false,"id":"b5ab5896829242b3ab2da3dcec9f9ee7","type":"page_info","conversion_output":false,"text":"14","text_display":"","confidence":0.99951171875,"confidence_rate":0.9997558295653994}],"page_height":2750,"page_width":2125,"languages_detected":[]},{"image_id":"0aec4542-8112-41df-bc16-87f7f6320bf6-15","page":15,"lines":[{"cnt":[[301,230],[1102,230],[1102,294],[301,294]],"region":{"top_left_x":300,"top_left_y":229,"width":803,"height":66},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95ca95d10ea44187b98bb00c602df885","type":"section_header","conversion_output":false,"children_ids":["5eca91c36b724b619f06b082891ef2fa"],"text":"","text_display":""},{"cnt":[[305,236],[1098,236],[1098,290],[305,290]],"region":{"top_left_x":305,"top_left_y":236,"width":793,"height":55},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eca91c36b724b619f06b082891ef2fa","type":"text","conversion_output":true,"parent_id":"95ca95d10ea44187b98bb00c602df885","text":"Appendix: Time and Events Schedule","text_display":"\n\n\\section*{Appendix: Time and Events 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