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Hogue, Jr., MD - Johns Hopkins University School of Medicine","confidence":1,"confidence_rate":1},{"cnt":[[138,466],[1253,466],[1253,511],[138,511]],"region":{"top_left_x":137,"top_left_y":466,"width":1116,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"069a502db9d147248a4b1d3e1897b234","type":"text","conversion_output":true,"text":"Pratik Pandharipande, MD - Vanderbilt University Medical Center","text_display":"\nPratik Pandharipande, MD - Vanderbilt University Medical Center","confidence":0.99951171875,"confidence_rate":0.9999928176655267},{"cnt":[[138,509],[939,509],[939,556],[138,556]],"region":{"top_left_x":137,"top_left_y":509,"width":802,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49bdd5b2d19a49028fb0831fd45cb63f","type":"text","conversion_output":true,"text":"Frederick Sieber, MD - Johns Hopkins Hospital","text_display":"\nFrederick Sieber, MD - Johns Hopkins Hospital","confidence":1,"confidence_rate":1},{"cnt":[[133,589],[410,589],[410,647],[133,647]],"region":{"top_left_x":133,"top_left_y":588,"width":278,"height":59},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92d10fd14cf74b6d8d99d62af580fde4","type":"section_header","conversion_output":false,"children_ids":["ec845dbac96e4bf7be20ff3dd03c9416"],"text":"","text_display":""},{"cnt":[[138,593],[406,593],[406,642],[138,642]],"region":{"top_left_x":137,"top_left_y":592,"width":270,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec845dbac96e4bf7be20ff3dd03c9416","type":"text","conversion_output":true,"parent_id":"92d10fd14cf74b6d8d99d62af580fde4","text":"Safety Officer:","text_display":"\n\n\\section*{Safety Officer:}","confidence":1,"confidence_rate":1},{"cnt":[[138,640],[1270,640],[1270,690],[138,690]],"region":{"top_left_x":137,"top_left_y":640,"width":1133,"height":50},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab33cb5ba96c48398279deb48c0f571b","type":"text","conversion_output":true,"text":"Charles Brown, MD- Johns Hopkins University School of Medicine","text_display":"\n\nCharles Brown, MD- Johns Hopkins University School of Medicine","confidence":1,"confidence_rate":1},{"cnt":[[138,726],[1813,726],[1813,776],[138,776]],"region":{"top_left_x":137,"top_left_y":726,"width":1677,"height":50},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0f3dd5a6520544bcadafa4ff3205b072","type":"text","conversion_output":true,"text":"Responsibilities include: reviewing and evaluating the study data to ensure participant safety, study","text_display":"\nResponsibilities include: reviewing and evaluating the study data to ensure participant safety, study","confidence":0.99853515625,"confidence_rate":0.9999861706835268},{"cnt":[[138,773],[1886,773],[1886,819],[138,819]],"region":{"top_left_x":137,"top_left_y":773,"width":1750,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82c45225857c43e9bf084362e8011a85","type":"text","conversion_output":true,"text":"conduct, progress, and efficacy, and making recommendations regarding the continuation, modification,","text_display":" conduct, progress, and efficacy, and making recommendations regarding the continuation, modification,","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[138,816],[595,816],[595,857],[138,857]],"region":{"top_left_x":137,"top_left_y":816,"width":459,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08f592d5213046a9ac6f0363c7ffb274","type":"text","conversion_output":true,"text":"and termination of the trial.","text_display":" and termination of the trial.","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1985,902],[1985,952],[120,952]],"region":{"top_left_x":120,"top_left_y":902,"width":1866,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76585d76c1054fd2a8f9a1be42e59b75","type":"text","conversion_output":true,"text":"INTRODUCTION: Postoperative delirium, arbitrarily defined as occurring within five days of surgery, affects up","text_display":"\n\nINTRODUCTION: Postoperative delirium, arbitrarily defined as occurring within five days of surgery, affects up","confidence":0.9921875,"confidence_rate":0.999931800782533},{"cnt":[[116,990],[1936,990],[1936,1038],[116,1038]],"region":{"top_left_x":116,"top_left_y":990,"width":1820,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9da24454816419896755991845120e1","type":"text","conversion_output":true,"text":"to \\(50 \\%\\) of patients older than sixty after a major operation. This geriatric syndrome is associated with longer","text_display":" to \\(50 \\%\\) of patients older than sixty after a major operation. This geriatric syndrome is associated with longer","confidence":0.9785699844360352,"confidence_rate":0.9998164323375457},{"cnt":[[116,1079],[1987,1079],[1987,1126],[116,1126]],"region":{"top_left_x":116,"top_left_y":1078,"width":1872,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d96a8319cbb4bdcb51606c7afbefbc3","type":"text","conversion_output":true,"text":"intensive care unit and hospital stay, readmission, persistent cognitive deterioration, and mortality. No effective","text_display":" intensive care unit and hospital stay, readmission, persistent cognitive deterioration, and mortality. No effective","confidence":1,"confidence_rate":1},{"cnt":[[116,1164],[1899,1164],[1899,1214],[116,1214]],"region":{"top_left_x":116,"top_left_y":1164,"width":1784,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc79b83ffc0a4a3a8ad1ea07e3f31ab2","type":"text","conversion_output":true,"text":"preventive methods have been identified, but preliminary evidence suggests that electroencephalography","text_display":" preventive methods have been identified, but preliminary evidence suggests that electroencephalography","confidence":1,"confidence_rate":1},{"cnt":[[116,1250],[1777,1250],[1777,1300],[116,1300]],"region":{"top_left_x":116,"top_left_y":1250,"width":1661,"height":50},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a30d95dcd1dc4f0abf900bd08dcfda8c","type":"text","conversion_output":true,"text":"(EEG) monitoring during general anesthesia, by facilitating reduced anesthetic exposure and EEG","text_display":" (EEG) monitoring during general anesthesia, by facilitating reduced anesthetic exposure and EEG","confidence":1,"confidence_rate":1},{"cnt":[[116,1341],[1944,1341],[1944,1388],[116,1388]],"region":{"top_left_x":116,"top_left_y":1340,"width":1829,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efec465f09844f358c652b0b04b51ccf","type":"text","conversion_output":true,"text":"suppression, might decrease incident postoperative delirium. This study hypothesizes that EEG-guidance of","text_display":" suppression, might decrease incident postoperative delirium. This study hypothesizes that EEG-guidance of","confidence":1,"confidence_rate":1},{"cnt":[[116,1427],[1869,1427],[1869,1476],[116,1476]],"region":{"top_left_x":116,"top_left_y":1426,"width":1754,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d51b079c78474cd0a7559d29331e57d5","type":"text","conversion_output":true,"text":"anesthetic administration prevents postoperative delirium and downstream sequelae, including falls and","text_display":" anesthetic administration prevents postoperative delirium and downstream sequelae, including falls and","confidence":1,"confidence_rate":1},{"cnt":[[116,1515],[537,1515],[537,1562],[116,1562]],"region":{"top_left_x":116,"top_left_y":1514,"width":422,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc08ef9fddf943dda39c48f182cd5ef6","type":"text","conversion_output":true,"text":"decreased quality of life.","text_display":" decreased quality of life.","confidence":1,"confidence_rate":1},{"cnt":[[116,1689],[1830,1689],[1830,1738],[116,1738]],"region":{"top_left_x":116,"top_left_y":1688,"width":1715,"height":51},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f8ae0c58a764c3d9256c221fbea72f8","type":"text","conversion_output":true,"text":"METHODS AND ANALYSIS: This is a 1,232 patient, block-randomized, double-blinded, comparative","text_display":"\n\nMETHODS AND ANALYSIS: This is a 1,232 patient, block-randomized, double-blinded, comparative","confidence":0.740234375,"confidence_rate":0.9969038913145608},{"cnt":[[116,1779],[1904,1779],[1904,1824],[116,1824]],"region":{"top_left_x":116,"top_left_y":1778,"width":1788,"height":47},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84bccece4d3647baa19c6470f2857478","type":"text","conversion_output":true,"text":"effectiveness trial. Patients older than sixty, undergoing volatile agent-based general anesthesia for major","text_display":" effectiveness trial. Patients older than sixty, undergoing volatile agent-based general anesthesia for major","confidence":1,"confidence_rate":1},{"cnt":[[116,1865],[1876,1865],[1876,1914],[116,1914]],"region":{"top_left_x":116,"top_left_y":1864,"width":1760,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"94560613486a4d968008691af63f7cd4","type":"text","conversion_output":true,"text":"surgery, are eligible. Subjects are randomized to one of two anesthetic approaches. One group receives","text_display":" surgery, are eligible. Subjects are randomized to one of two anesthetic approaches. One group receives","confidence":1,"confidence_rate":1},{"cnt":[[116,1951],[1897,1951],[1897,2000],[116,2000]],"region":{"top_left_x":116,"top_left_y":1950,"width":1782,"height":51},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd1dad9435da489587fea5f3e805a436","type":"text","conversion_output":true,"text":"general anesthesia with clinicians blinded to EEG monitoring. The other group receives EEG-guidance of","text_display":" general anesthesia with clinicians blinded to EEG monitoring. The other group receives EEG-guidance of","confidence":1,"confidence_rate":1},{"cnt":[[116,2037],[1996,2037],[1996,2088],[116,2088]],"region":{"top_left_x":116,"top_left_y":2036,"width":1880,"height":53},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2418565d97f04f959623fd32b4024073","type":"text","conversion_output":true,"text":"anesthetic agent administration. The outcomes of postoperative delirium ( \\(\\leq 5\\) days), falls ( \\(\\leq 1\\) month) and health-","text_display":" anesthetic agent administration. The outcomes of postoperative delirium ( \\(\\leq 5\\) days), falls ( \\(\\leq 1\\) month) and health-","confidence":0.98828125,"confidence_rate":0.9999049403591633}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-10","page":10,"lines":[{"cnt":[[120,157],[1916,157],[1916,208],[120,208]],"region":{"top_left_x":120,"top_left_y":156,"width":1797,"height":53},"line":1,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"503aff318e51482eb7b25f7564a4cfb4","type":"text","conversion_output":true,"text":"between groups will be will be presented with \\(95 \\%\\) confidence intervals, and will be considered statistically","text_display":"\nbetween groups will be will be presented with \\(95 \\%\\) confidence intervals, and will be considered statistically","confidence":0.9951193332672119,"confidence_rate":0.9999578231646138},{"cnt":[[120,243],[683,243],[683,294],[120,294]],"region":{"top_left_x":120,"top_left_y":242,"width":564,"height":53},"line":2,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bc2c384e68c0438aa447ff39163f6260","type":"text","conversion_output":true,"text":"significant at a two-sided \\(p <0.05\\).","text_display":" significant at a two-sided \\(p <0.05\\).","confidence":0.5382731147110462,"confidence_rate":0.9866252647672019},{"cnt":[[120,417],[1865,417],[1865,471],[120,471]],"region":{"top_left_x":120,"top_left_y":416,"width":1745,"height":55},"line":3,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"3fd8c53b86a34ef6b53c2c1fec225ad2","type":"text","conversion_output":true,"text":"ETHICS AND DISSEMINATION: ENGAGES is approved by the ethics board at Washington University.","text_display":"\n\nETHICS AND DISSEMINATION: ENGAGES is approved by the ethics board at Washington University.","confidence":0.99853515625,"confidence_rate":0.9999847301407262},{"cnt":[[120,505],[1888,505],[1888,556],[120,556]],"region":{"top_left_x":120,"top_left_y":504,"width":1769,"height":53},"line":4,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e42711b2cf184390bf490a098843273d","type":"text","conversion_output":true,"text":"Recruitment began in January 2015. Dissemination plans include presentations at scientific conferences,","text_display":"\nRecruitment began in January 2015. 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of the electroencephalography-guided anesthetic protocol will depend on clinicians'","confidence":0.38811776156848055,"confidence_rate":0.9912748933109646},{"cnt":[[245,1757],[694,1757],[694,1807],[245,1807]],"region":{"top_left_x":244,"top_left_y":1757,"width":450,"height":50},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"45b8d99c4a5b4b2cb62405136783a566","type":"text","conversion_output":true,"text":"adherence to the protocol.","text_display":" adherence to the protocol.","confidence":1,"confidence_rate":1},{"cnt":[[185,1798],[1884,1798],[1884,1858],[185,1858]],"region":{"top_left_x":184,"top_left_y":1798,"width":1701,"height":61},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e0a7b6a01b0c4d199331dd70f9927a9f","type":"text","conversion_output":true,"text":"FR As delirium is a fluctuating disorder, it may occasionally be missed despite rigorous and validated","text_display":"\nFR As delirium is a fluctuating disorder, it may occasionally be missed despite rigorous and validated","confidence":0.263436088475828,"confidence_rate":0.9876106173366157},{"cnt":[[245,1852],[621,1852],[621,1897],[245,1897]],"region":{"top_left_x":244,"top_left_y":1851,"width":377,"height":47},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"71f35917e11e4bc58309c1e968d25ef0","type":"text","conversion_output":true,"text":"assessment methods.","text_display":" assessment methods.","confidence":1,"confidence_rate":1},{"cnt":[[185,1893],[1964,1893],[1964,1949],[185,1949]],"region":{"top_left_x":184,"top_left_y":1892,"width":1780,"height":57},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5325b4455311487a993c2ec112c940f8","type":"text","conversion_output":true,"text":"君四 Some patients might be unable to speak in the early postoperative period (e.g. have a tracheal tube in","text_display":"\n君四 Some patients might be unable to speak in the early postoperative period (e.g. have a tracheal tube in","confidence":0.08717582076446691,"confidence_rate":0.9798733971337176},{"cnt":[[245,1942],[1300,1942],[1300,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1942,"width":1056,"height":54},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"cf2f335cb79a4ea8b1f05be00f2392b3","type":"text","conversion_output":true,"text":"place), which will curtail the sensitivity of delirium assessment.","text_display":" place), which will curtail the sensitivity of delirium assessment.","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-11","page":11,"lines":[{"cnt":[[116,150],[357,150],[357,208],[116,208]],"region":{"top_left_x":116,"top_left_y":150,"width":241,"height":59},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e8ac1454a7a46dfad8c945415d76353","type":"section_header","conversion_output":false,"children_ids":["f8f02e181bb24b79b312fc2f8b0013e6"],"text":"","text_display":""},{"cnt":[[120,155],[350,155],[350,204],[120,204]],"region":{"top_left_x":120,"top_left_y":154,"width":231,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8f02e181bb24b79b312fc2f8b0013e6","type":"text","conversion_output":true,"parent_id":"7e8ac1454a7a46dfad8c945415d76353","text":"Background","text_display":"\n\n\\section*{Background}","confidence":1,"confidence_rate":1},{"cnt":[[116,243],[1949,243],[1949,290],[116,290]],"region":{"top_left_x":116,"top_left_y":242,"width":1833,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e770154e20241c29a4e58191f072aa7","type":"text","conversion_output":true,"text":"Within the next forty years, \\(>110\\) million Americans will exceed the age of \\(60,{ }^{1}\\) and many of them \\((>40 \\%)\\) will","text_display":"\n\nWithin the next forty years, \\(>110\\) million Americans will exceed the age of \\(60,{ }^{1}\\) and many of them \\((>40 \\%)\\) will","confidence":0.49145012137114463,"confidence_rate":0.994508198736217},{"cnt":[[118,288],[1841,288],[1841,335],[118,335]],"region":{"top_left_x":118,"top_left_y":287,"width":1724,"height":49},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1786edd07ee24d5a99e0bc1ef0f6d8d2","type":"text","conversion_output":true,"text":"require elective surgery. \\({ }^{2}\\) The geriatric syndrome of postoperative delirium is one of the most common","text_display":" require elective surgery. \\({ }^{2}\\) The geriatric syndrome of postoperative delirium is one of the most common","confidence":1,"confidence_rate":1},{"cnt":[[116,331],[1953,331],[1953,380],[116,380]],"region":{"top_left_x":116,"top_left_y":330,"width":1837,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7757974206804a1b98466165817693f9","type":"text","conversion_output":true,"text":"complications observed with the physiological stress of major surgery and anesthesia. It affects up to \\(70 \\%\\) of","text_display":" complications observed with the physiological stress of major surgery and anesthesia. It affects up to \\(70 \\%\\) of","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[116,374],[1953,374],[1953,423],[116,423]],"region":{"top_left_x":116,"top_left_y":373,"width":1837,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3f6a5c469274f669c288f8883639bfe","type":"text","conversion_output":true,"text":"surgical patients older than 60 , with most studies showing an incidence of \\(30 \\%\\) to \\(50 \\% .^{3}\\) Delirium is an acute","text_display":" surgical patients older than 60 , with most studies showing an incidence of \\(30 \\%\\) to \\(50 \\% .^{3}\\) Delirium is an acute","confidence":0.7286479473114014,"confidence_rate":0.9975678502566392},{"cnt":[[116,419],[1953,419],[1953,466],[116,466]],"region":{"top_left_x":116,"top_left_y":418,"width":1837,"height":49},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25580a00b20343b0b8ab4796f90d3ae6","type":"text","conversion_output":true,"text":"and fluctuating neurologic disorder that reflects a change from baseline cognition and is characterized by the","text_display":" and fluctuating neurologic disorder that reflects a change from baseline cognition and is characterized by the","confidence":1,"confidence_rate":1},{"cnt":[[116,460],[1884,460],[1884,509],[116,509]],"region":{"top_left_x":116,"top_left_y":459,"width":1769,"height":51},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3be356a9a764ce7b00380a04a3a645f","type":"text","conversion_output":true,"text":"cardinal features of inattention and disorganized thinking. \\({ }^{4}\\) Postoperative delirium typically first manifests","text_display":" cardinal features of inattention and disorganized thinking. \\({ }^{4}\\) Postoperative delirium typically first manifests","confidence":1,"confidence_rate":1},{"cnt":[[116,507],[1910,507],[1910,554],[116,554]],"region":{"top_left_x":116,"top_left_y":507,"width":1794,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97cf39f5d15a458cbe6949e06462f7f7","type":"text","conversion_output":true,"text":"between 24 and 96 hours following the surgical intervention. While it is unclear why postoperative delirium","text_display":" between 24 and 96 hours following the surgical intervention. While it is unclear why postoperative delirium","confidence":1,"confidence_rate":1},{"cnt":[[116,550],[1985,550],[1985,597],[116,597]],"region":{"top_left_x":116,"top_left_y":550,"width":1870,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"027a8e5a83d84b9ba9216667372062a3","type":"text","conversion_output":true,"text":"occurs so frequently, consistently described risk factors for delirium include older age, male sex, mild cognitive","text_display":" occurs so frequently, consistently described risk factors for delirium include older age, male sex, mild cognitive","confidence":1,"confidence_rate":1},{"cnt":[[116,593],[1351,593],[1351,642],[116,642]],"region":{"top_left_x":116,"top_left_y":592,"width":1236,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a710721ffb045cea2e3452faa8eac23","type":"text","conversion_output":true,"text":"impairment, dementia, sensory impairment, and chronic medical illness. \\({ }^{5}\\)","text_display":" impairment, dementia, sensory impairment, and chronic medical illness. \\({ }^{5}\\)","confidence":0.99462890625,"confidence_rate":0.9999351157203459},{"cnt":[[116,681],[1901,681],[1901,728],[116,728]],"region":{"top_left_x":116,"top_left_y":681,"width":1786,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"23acc753aaad41adb65a362f15f94097","type":"text","conversion_output":true,"text":"Postoperative delirium has substantial implications at a societal level, for healthcare professionals and for","text_display":"\n\nPostoperative delirium has substantial implications at a societal level, for healthcare professionals and for","confidence":1,"confidence_rate":1},{"cnt":[[116,726],[1974,726],[1974,771],[116,771]],"region":{"top_left_x":116,"top_left_y":726,"width":1859,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5f68897ea9a42a4ab98f69089315d9b","type":"text","conversion_output":true,"text":"individual patients and their families. It is estimated that delirium is associated with additional healthcare costs","text_display":" individual patients and their families. It is estimated that delirium is associated with additional healthcare costs","confidence":1,"confidence_rate":1},{"cnt":[[116,767],[1893,767],[1893,816],[116,816]],"region":{"top_left_x":116,"top_left_y":766,"width":1777,"height":51},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83d95ccd7470468486cc46681bf3d2ba","type":"text","conversion_output":true,"text":"exceeding \\(\\$ 60,000\\) per patient per year. \\({ }^{6}\\) Both the occurrence and the duration of delirium are linked with","text_display":" exceeding \\(\\$ 60,000\\) per patient per year. \\({ }^{6}\\) Both the occurrence and the duration of delirium are linked with","confidence":0.9854049682617188,"confidence_rate":0.9998814377789595},{"cnt":[[116,812],[1936,812],[1936,862],[116,862]],"region":{"top_left_x":116,"top_left_y":812,"width":1820,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b7cafcf4f6b4094bd9e6cda95edca5d","type":"text","conversion_output":true,"text":"increased morbidity and mortality, prolonged length of hospital and intensive care unit (ICU) stay, as well as","text_display":" increased morbidity and mortality, prolonged length of hospital and intensive care unit (ICU) stay, as well as","confidence":1,"confidence_rate":1},{"cnt":[[116,855],[1796,855],[1796,904],[116,904]],"region":{"top_left_x":116,"top_left_y":855,"width":1681,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f8a8739592d4b10b44286939bc4ba3b","type":"text","conversion_output":true,"text":"functional and cognitive decline necessitating nursing home or long-term care facility placement. \\({ }^{7-10}\\)","text_display":" functional and cognitive decline necessitating nursing home or long-term care facility placement. \\({ }^{7-10}\\)","confidence":1,"confidence_rate":1},{"cnt":[[116,900],[1927,900],[1927,947],[116,947]],"region":{"top_left_x":116,"top_left_y":900,"width":1812,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56f35578f5a848b19f1bb9baf7904b2d","type":"text","conversion_output":true,"text":"Preoperative surveys completed by 1,000 patients at our institution, Barnes-Jewish Hospital, a tertiary care","text_display":" Preoperative surveys completed by 1,000 patients at our institution, Barnes-Jewish Hospital, a tertiary care","confidence":0.99853515625,"confidence_rate":0.9999873628584485},{"cnt":[[116,945],[1912,945],[1912,990],[116,990]],"region":{"top_left_x":116,"top_left_y":945,"width":1797,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21e1188799da471d9ba6e5f51e2e905e","type":"text","conversion_output":true,"text":"facility at Washington University in St. Louis, showed that approximately \\(40 \\%\\) of surgical patients highlight","text_display":" facility at Washington University in St. Louis, showed that approximately \\(40 \\%\\) of surgical patients highlight","confidence":0.978515625,"confidence_rate":0.9998127888714093},{"cnt":[[116,988],[1936,988],[1936,1033],[116,1033]],"region":{"top_left_x":116,"top_left_y":988,"width":1820,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d127cadfc3b5447aa36c6c03dad379b6","type":"text","conversion_output":true,"text":"postoperative delirium (or acute confusion) as one of their top concerns, and \\(30 \\%\\) of all patients are worried","text_display":" postoperative delirium (or acute confusion) as one of their top concerns, and \\(30 \\%\\) of all patients are worried","confidence":0.99951171875,"confidence_rate":0.999995825645481},{"cnt":[[116,1031],[1921,1031],[1921,1079],[116,1079]],"region":{"top_left_x":116,"top_left_y":1031,"width":1805,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7065b3453b644f96b31aa9ca40487453","type":"text","conversion_output":true,"text":"that they will still have problems thinking normally when they return home to recover. Another survey study","text_display":" that they will still have problems thinking normally when they return home to recover. Another survey study","confidence":1,"confidence_rate":1},{"cnt":[[116,1074],[1979,1074],[1979,1124],[116,1124]],"region":{"top_left_x":116,"top_left_y":1074,"width":1863,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f037572239b4a63b2d676d6839b466f","type":"text","conversion_output":true,"text":"showed that, when in-hospital delirium occurs, patients' family members are deeply affected by both the acute","text_display":" showed that, when in-hospital delirium occurs, patients' family members are deeply affected by both the acute","confidence":1,"confidence_rate":1},{"cnt":[[116,1117],[1076,1117],[1076,1167],[116,1167]],"region":{"top_left_x":116,"top_left_y":1117,"width":961,"height":50},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8bf2ce82491404c904cbaeec2cc2e3b","type":"text","conversion_output":true,"text":"neurologic deterioration and the impact upon recovery. \\({ }^{11}\\)","text_display":" neurologic deterioration and the impact upon recovery. \\({ }^{11}\\)","confidence":1,"confidence_rate":1},{"cnt":[[116,1205],[1931,1205],[1931,1253],[116,1253]],"region":{"top_left_x":116,"top_left_y":1205,"width":1816,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdbd1974b7d34bdc8e52b81adc4a2c59","type":"text","conversion_output":true,"text":"Delirious patients are unable to participate effectively in rehabilitation and are therefore susceptible to other","text_display":"\n\nDelirious patients are unable to participate effectively in rehabilitation and are therefore susceptible to other","confidence":1,"confidence_rate":1},{"cnt":[[116,1250],[1899,1250],[1899,1298],[116,1298]],"region":{"top_left_x":116,"top_left_y":1250,"width":1784,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"822842b24fee4ac68726e24da4fa71b0","type":"text","conversion_output":true,"text":"postoperative geriatric syndromes and adverse events, including falls, pressure ulcers, functional decline,","text_display":" postoperative geriatric syndromes and adverse events, including falls, pressure ulcers, functional decline,","confidence":1,"confidence_rate":1},{"cnt":[[116,1293],[1914,1293],[1914,1341],[116,1341]],"region":{"top_left_x":116,"top_left_y":1293,"width":1799,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14d04f86ff1e434992db8362e4c8d27c","type":"text","conversion_output":true,"text":"pneumonia, hospital readmission, and discharge to a nursing home or extended care facility. \\({ }^{8,12-16}\\) There is","text_display":" pneumonia, hospital readmission, and discharge to a nursing home or extended care facility. \\({ }^{8,12-16}\\) There is","confidence":0.99951171875,"confidence_rate":0.9999960292721264},{"cnt":[[116,1336],[1841,1336],[1841,1386],[116,1386]],"region":{"top_left_x":116,"top_left_y":1336,"width":1726,"height":50},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dd75e419bc24d7fa2d5505a216bfa58","type":"text","conversion_output":true,"text":"even evidence that patients who have periods of delirium while in hospital may continue to experience","text_display":" even evidence that patients who have periods of delirium while in hospital may continue to experience","confidence":1,"confidence_rate":1},{"cnt":[[116,1381],[1949,1381],[1949,1429],[116,1429]],"region":{"top_left_x":116,"top_left_y":1381,"width":1833,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5b003af05f5f42488b402a8ed049aa0b","type":"text","conversion_output":true,"text":"persistent delirium after going home and among these patients, the risks of mortality, institutionalization, and","text_display":" persistent delirium after going home and among these patients, the risks of mortality, institutionalization, and","confidence":1,"confidence_rate":1},{"cnt":[[116,1422],[1983,1422],[1983,1472],[116,1472]],"region":{"top_left_x":116,"top_left_y":1422,"width":1868,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0750bdfbd43d4de98d14f28f3702bf9a","type":"text","conversion_output":true,"text":"functional and cognitive decline are even worse than those patients who experienced delirium but recovered. \\({ }^{17}\\)","text_display":" functional and cognitive decline are even worse than those patients who experienced delirium but recovered. \\({ }^{17}\\)","confidence":1,"confidence_rate":1},{"cnt":[[116,1467],[1904,1467],[1904,1515],[116,1515]],"region":{"top_left_x":116,"top_left_y":1467,"width":1788,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"632aad54f9cc41de8e7dcd261428ee68","type":"text","conversion_output":true,"text":"Patients who experience postoperative delirium report persistently decreased quality of life. \\({ }^{8}\\) Furthermore,","text_display":" Patients who experience postoperative delirium report persistently decreased quality of life. \\({ }^{8}\\) Furthermore,","confidence":1,"confidence_rate":1},{"cnt":[[116,1512],[1798,1512],[1798,1558],[116,1558]],"region":{"top_left_x":116,"top_left_y":1512,"width":1683,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d54193dc69ce41a5a21e2e87fcf034fc","type":"text","conversion_output":true,"text":"additional studies suggest that incidence and duration of delirium may be associated with long-term","text_display":" additional studies suggest that incidence and duration of delirium may be associated with long-term","confidence":1,"confidence_rate":1},{"cnt":[[116,1555],[1951,1555],[1951,1605],[116,1605]],"region":{"top_left_x":116,"top_left_y":1555,"width":1835,"height":50},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35e45201b5f44861b0b7de2a712c6178","type":"text","conversion_output":true,"text":"postoperative cognitive dysfunction. \\({ }^{18,19}\\) It is therefore a public health priority to test plausible interventions to","text_display":" postoperative cognitive dysfunction. \\({ }^{18,19}\\) It is therefore a public health priority to test plausible interventions to","confidence":0.99951171875,"confidence_rate":0.9999963278225461},{"cnt":[[116,1601],[952,1601],[952,1648],[116,1648]],"region":{"top_left_x":116,"top_left_y":1600,"width":836,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"439c6456df234d9e8e839a40526b5563","type":"text","conversion_output":true,"text":"prevent, identify and treat postoperative delirium.","text_display":" prevent, identify and treat postoperative delirium.","confidence":1,"confidence_rate":1},{"cnt":[[116,1687],[1970,1687],[1970,1734],[116,1734]],"region":{"top_left_x":116,"top_left_y":1686,"width":1855,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"647551be077d480092a133e5e69df9ea","type":"text","conversion_output":true,"text":"Even though postoperative delirium is a pressing healthcare concern, there are barriers to making progress in","text_display":"\n\nEven though postoperative delirium is a pressing healthcare concern, there are barriers to making progress in","confidence":0.9990236759185791,"confidence_rate":0.9999914316069175},{"cnt":[[116,1732],[1949,1732],[1949,1777],[116,1777]],"region":{"top_left_x":116,"top_left_y":1731,"width":1833,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c6c11b118e240f6a68d7894e00ad70f","type":"text","conversion_output":true,"text":"its prevention and treatment. Delirium is difficult to diagnose as most patients with delirium are hypoactive or","text_display":" its prevention and treatment. Delirium is difficult to diagnose as most patients with delirium are hypoactive or","confidence":1,"confidence_rate":1},{"cnt":[[116,1775],[1843,1775],[1843,1824],[116,1824]],"region":{"top_left_x":116,"top_left_y":1774,"width":1728,"height":51},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc1ad5b686604b31b106f969ee899512","type":"text","conversion_output":true,"text":"lethargic, \\({ }^{20}\\) while medical staff typically recognize delirium when patients are hyperactive and agitated.","text_display":" lethargic, \\({ }^{20}\\) while medical staff typically recognize delirium when patients are hyperactive and agitated.","confidence":1,"confidence_rate":1},{"cnt":[[116,1818],[1927,1818],[1927,1867],[116,1867]],"region":{"top_left_x":116,"top_left_y":1817,"width":1812,"height":50},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4148bbcdd88e44119573051ca3ba9d84","type":"text","conversion_output":true,"text":"Hypoactive characteristics may also be easily regarded as a normal phenotype in a patient recovering from","text_display":" Hypoactive characteristics may also be easily regarded as a normal phenotype in a patient recovering from","confidence":1,"confidence_rate":1},{"cnt":[[116,1863],[1983,1863],[1983,1910],[116,1910]],"region":{"top_left_x":116,"top_left_y":1862,"width":1868,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08dfdd4eb478424488c3a95a2665b84f","type":"text","conversion_output":true,"text":"surgery or general anesthesia. Furthermore, no group of healthcare practitioners involved in the direct surgical","text_display":" surgery or general anesthesia. Furthermore, no group of healthcare practitioners involved in the direct surgical","confidence":1,"confidence_rate":1},{"cnt":[[116,1908],[1987,1908],[1987,1953],[116,1953]],"region":{"top_left_x":116,"top_left_y":1907,"width":1872,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d42d07347304ecf899ff8b670845138","type":"text","conversion_output":true,"text":"care of patients has taken ownership of delirium as a priority needing their attention. It is not currently standard","text_display":" care of patients has taken ownership of delirium as a priority needing their attention. It is not currently standard","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[116,1951],[1996,1951],[1996,1996],[116,1996]],"region":{"top_left_x":116,"top_left_y":1950,"width":1880,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2734260730be490ea17abcf0ca9d6bf7","type":"text","conversion_output":true,"text":"of care to routinely assess surgical patients for delirium, approaches for preventing postoperative delirium have","text_display":" of care to routinely assess surgical patients for delirium, approaches for preventing postoperative delirium have","confidence":1,"confidence_rate":1},{"cnt":[[116,1994],[1899,1994],[1899,2039],[116,2039]],"region":{"top_left_x":116,"top_left_y":1993,"width":1784,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4b3b83ca31a47a29a12b279bc588a47","type":"text","conversion_output":true,"text":"not been applied to surgical patients, and treatment options for delirium are limited. Delirium is a common","text_display":" not been applied to surgical patients, and treatment options for delirium are limited. Delirium is a common","confidence":1,"confidence_rate":1},{"cnt":[[116,2037],[1858,2037],[1858,2084],[116,2084]],"region":{"top_left_x":116,"top_left_y":2036,"width":1743,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a3fcbe2f7024d0c8b217c02ee3ca657","type":"text","conversion_output":true,"text":"complication of surgery and anesthesia with serious consequences for patients and their families, yet it","text_display":" complication of surgery and anesthesia with serious consequences for patients and their families, yet it","confidence":1,"confidence_rate":1},{"cnt":[[116,2082],[1996,2082],[1996,2125],[116,2125]],"region":{"top_left_x":116,"top_left_y":2081,"width":1880,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c97fd47d946c4961a5da767c7ebca7a6","type":"text","conversion_output":true,"text":"remains an orphan problem and no effective prophylactic or curative treatments for postoperative delirium have","text_display":" remains an orphan problem and no effective prophylactic or curative treatments for postoperative delirium have","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-12","page":12,"lines":[{"cnt":[[120,159],[1957,159],[1957,202],[120,202]],"region":{"top_left_x":120,"top_left_y":158,"width":1838,"height":44},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cb6626d80984627a601cd78aa6d1010","type":"text","conversion_output":true,"text":"early rehabilitation, early discharge planning, prepared environment, patient-centered care), all of which have","text_display":"\nearly rehabilitation, early discharge planning, prepared environment, patient-centered care), all of which have","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1858,202],[1858,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1739,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ca3a3e932fb48838b91f485266bfb22","type":"text","conversion_output":true,"text":"been shown to decrease geriatric syndromes, such as falls, in vulnerable patients. \\({ }^{24,25}\\) Identifying and if","text_display":" been shown to decrease geriatric syndromes, such as falls, in vulnerable patients. \\({ }^{24,25}\\) Identifying and if","confidence":1,"confidence_rate":1},{"cnt":[[120,247],[1953,247],[1953,290],[120,290]],"region":{"top_left_x":120,"top_left_y":247,"width":1833,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fc01006bc1bc4dd3b8879a482036746a","type":"text","conversion_output":true,"text":"possible preventing delirium in surgical patients might present an important opportunity to improve numerous","text_display":" possible preventing delirium in surgical patients might present an important opportunity to improve numerous","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1012,288],[1012,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":892,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfbe2ebdfdd14eb583ee87cd6d6d8887","type":"text","conversion_output":true,"text":"outcomes beyond a reduction in the delirium burden.","text_display":" outcomes beyond a reduction in the delirium burden.","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1989,378],[1989,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1870,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceaf70a4cf8a4d3481fb71f5f39a77de","type":"text","conversion_output":true,"text":"Although it is very likely that anesthetic management contributes to the occurrence of postoperative delirium, to","text_display":"\n\nAlthough it is very likely that anesthetic management contributes to the occurrence of postoperative delirium, to","confidence":0.9965834617614746,"confidence_rate":0.9999709971330244},{"cnt":[[120,421],[1970,421],[1970,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1851,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab17310183964fbdb814afcf2fb38e15","type":"text","conversion_output":true,"text":"date there are no validated anesthetic approaches to preventing delirium. Four randomized, controlled studies","text_display":" date there are no validated anesthetic approaches to preventing delirium. Four randomized, controlled studies","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1923,464],[1923,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1803,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f3c5dd67c2c4dbbaf6a926373234ba5","type":"text","conversion_output":true,"text":"in diverse surgical settings have suggested a decrease in postoperative delirium with bispectral index (BIS)","text_display":" in diverse surgical settings have suggested a decrease in postoperative delirium with bispectral index (BIS)","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1987,507],[1987,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1868,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9255a0f37d984e85aa3ab0d47ca9dc45","type":"text","conversion_output":true,"text":"guidance of general anesthesia. \\({ }^{26-29}\\) The BIS is one of several proprietary electroencephalogram (EEG) indices","text_display":" guidance of general anesthesia. \\({ }^{26-29}\\) The BIS is one of several proprietary electroencephalogram (EEG) indices","confidence":1,"confidence_rate":1},{"cnt":[[120,554],[1957,554],[1957,595],[120,595]],"region":{"top_left_x":120,"top_left_y":554,"width":1838,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d5586c1aa1f4f04962dccd7e403ff2a","type":"text","conversion_output":true,"text":"of anesthetic depth, based on EEG waveform processing, with numbers approaching 100 suggesting arousal","text_display":" of anesthetic depth, based on EEG waveform processing, with numbers approaching 100 suggesting arousal","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[120,593],[1914,595],[1914,642]],"region":{"top_left_x":120,"top_left_y":592,"width":1795,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d591f4b4d78f44e283c475157aa4c0c9","type":"text","conversion_output":true,"text":"or wakefulness, and numbers approaching 0 reflecting absent detectable brain electrical activity. \\({ }^{30} A\\) meta-","text_display":" or wakefulness, and numbers approaching 0 reflecting absent detectable brain electrical activity. \\({ }^{30} A\\) meta","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[1888,640],[1888,683],[120,683]],"region":{"top_left_x":120,"top_left_y":640,"width":1769,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6e904e834a040b68831cebd31f39af4","type":"text","conversion_output":true,"text":"analysis of these four randomized controlled trials showed that EEG (or BIS) guidance of anesthesia was","text_display":"analysis of these four randomized controlled trials showed that EEG (or BIS) guidance of anesthesia was","confidence":1,"confidence_rate":1},{"cnt":[[120,683],[1949,683],[1949,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1829,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dfdc5e79d8764fb3861cb9a88d339271","type":"text","conversion_output":true,"text":"associated with a marked reduction in postoperative delirium with a pooled odds ratio of 0.56 ( \\(95 \\% CI\\), \\(0.42-\\)","text_display":" associated with a marked reduction in postoperative delirium with a pooled odds ratio of 0.56 ( \\(95 \\% CI\\), \\(0.42-\\)","confidence":0.4225467835403125,"confidence_rate":0.9929637636027208},{"cnt":[[120,726],[1957,726],[1957,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1838,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82443b63256d488992facbd772f31c78","type":"text","conversion_output":true,"text":"0.73 , heterogeneity P value \\(=0.54\\) ). \\({ }^{29}\\) Also of interest are several studies that have examined the relationship","text_display":" 0.73 , heterogeneity P value \\(=0.54\\) ). \\({ }^{29}\\) Also of interest are several studies that have examined the relationship","confidence":0.86865234375,"confidence_rate":0.9989651512778895},{"cnt":[[120,769],[1953,769],[1953,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1833,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1894681a3e7a4220bed560d6fa114f17","type":"text","conversion_output":true,"text":"between low intraoperative BIS values and intermediate term postoperative mortality. \\({ }^{31-35}\\) Building on these a","text_display":" between low intraoperative BIS values and intermediate term postoperative mortality. \\({ }^{31-35}\\) Building on these a","confidence":1,"confidence_rate":1},{"cnt":[[120,814],[1987,814],[1987,857],[120,857]],"region":{"top_left_x":120,"top_left_y":814,"width":1868,"height":44},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d95164939b5a4a2a95ca0d7dd3ac0f7a","type":"text","conversion_output":true,"text":"study has demonstrated that intraoperative EEG burst suppression specifically, especially when coinciding with","text_display":" study has demonstrated that intraoperative EEG burst suppression specifically, especially when coinciding with","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1384,855],[1384,902],[120,902]],"region":{"top_left_x":120,"top_left_y":855,"width":1264,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4d4c2ac84dc44de594d177f1e7535025","type":"text","conversion_output":true,"text":"hypotension, is associated with increased 90-day postoperative mortality. \\({ }^{36}\\)","text_display":" hypotension, is associated with increased 90-day postoperative mortality. \\({ }^{36}\\)","confidence":0.88037109375,"confidence_rate":0.9985365688387559},{"cnt":[[116,984],[1852,984],[1852,1081],[116,1081]],"region":{"top_left_x":116,"top_left_y":983,"width":1736,"height":98},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed63e93ad24249f5abe6a99c2ad8d0f9","type":"section_header","conversion_output":false,"children_ids":["01f5344b7e88462a8f5f67c9255626bf","e6d70206f9d74dc295c07d2cf08e5852"],"text":"","text_display":""},{"cnt":[[122,988],[1848,988],[1848,1033],[122,1033]],"region":{"top_left_x":122,"top_left_y":988,"width":1726,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01f5344b7e88462a8f5f67c9255626bf","type":"text","conversion_output":true,"parent_id":"ed63e93ad24249f5abe6a99c2ad8d0f9","text":"Figure 1: Stylized common electroencephalograph (EEG) patterns from frontal EEG channel seen with","text_display":"\n\n\\section*{Figure 1: Stylized common electroencephalograph (EEG) patterns from frontal EEG channel seen with","confidence":0.95703125,"confidence_rate":0.9995695119617255},{"cnt":[[120,1036],[1192,1036],[1192,1076],[120,1076]],"region":{"top_left_x":120,"top_left_y":1035,"width":1073,"height":42},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e6d70206f9d74dc295c07d2cf08e5852","type":"text","conversion_output":true,"parent_id":"ed63e93ad24249f5abe6a99c2ad8d0f9","text":"progressively increasing anesthetic depth. BIS, bispectral index","text_display":" progressively increasing anesthetic depth. BIS, bispectral index}","confidence":1,"confidence_rate":1},{"cnt":[[122,1121],[1953,1121],[1953,1162],[122,1162]],"region":{"top_left_x":122,"top_left_y":1121,"width":1831,"height":42},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"72477a8033654ebdaffe0f97def57be5","type":"text","conversion_output":true,"text":"Despite the findings from these studies and recommendations from the National Institute for Health and Care","text_display":"\n\nDespite the findings from these studies and recommendations from the National Institute for Health and Care","confidence":0.9990236759185791,"confidence_rate":0.9999912786005654},{"cnt":[[125,1164],[1946,1164],[1946,1207],[125,1207]],"region":{"top_left_x":124,"top_left_y":1164,"width":1823,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c568e45046d749e184a77ee8e4495d2a","type":"text","conversion_output":true,"text":"Excellence in the United Kingdom that electroencephalography guidance of anesthesia should be routine for","text_display":" Excellence in the United Kingdom that electroencephalography guidance of anesthesia should be routine for","confidence":1,"confidence_rate":1},{"cnt":[[120,1207],[1989,1207],[1989,1250],[120,1250]],"region":{"top_left_x":120,"top_left_y":1207,"width":1870,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7619816f3a14a55858257a42d2991b6","type":"text","conversion_output":true,"text":"vulnerable patients, \\({ }^{37}\\) intraoperative EEG monitoring has not become standard anesthetic practice, and there is","text_display":" vulnerable patients, \\({ }^{37}\\) intraoperative EEG monitoring has not become standard anesthetic practice, and there is","confidence":1,"confidence_rate":1},{"cnt":[[122,1250],[1970,1250],[1970,1296],[122,1296]],"region":{"top_left_x":122,"top_left_y":1250,"width":1849,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"353e53019d3247c6bd9da4c28fd0e95d","type":"text","conversion_output":true,"text":"ongoing controversy about the utility of electroencephalography guidance of anesthesia. \\({ }^{38}\\) For example, in the","text_display":" ongoing controversy about the utility of electroencephalography guidance of anesthesia. \\({ }^{38}\\) For example, in the","confidence":1,"confidence_rate":1},{"cnt":[[120,1293],[1938,1293],[1938,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1818,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e43200f465b6418e99c3272cbc80ab0b","type":"text","conversion_output":true,"text":"United Kingdom only \\(2 \\%\\) of anesthesia practitioners routinely incorporate EEG monitoring in their practice, \\({ }^{39}\\)","text_display":" United Kingdom only \\(2 \\%\\) of anesthesia practitioners routinely incorporate EEG monitoring in their practice, \\({ }^{39}\\)","confidence":0.9941432476043701,"confidence_rate":0.9999522452831326},{"cnt":[[120,1336],[1987,1336],[1987,1381],[120,1381]],"region":{"top_left_x":120,"top_left_y":1336,"width":1868,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4e943fa655b4985b1c161e76991b6ff","type":"text","conversion_output":true,"text":"and it is possible that adoption is similarly low in the United States. The results of several clinical trials have led","text_display":" and it is possible that adoption is similarly low in the United States. The results of several clinical trials have led","confidence":0.99853515625,"confidence_rate":0.9999881781530843},{"cnt":[[120,1384],[1979,1384],[1979,1424],[120,1424]],"region":{"top_left_x":120,"top_left_y":1383,"width":1859,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"37b331e654c742cf850c9c1ccfbf4828","type":"text","conversion_output":true,"text":"anesthesia practitioners to question whether EEG-guidance meaningfully changes anesthetic administration in","text_display":" anesthesia practitioners to question whether EEG-guidance meaningfully changes anesthetic administration in","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,1422],[1934,1422],[1934,1470],[120,1470]],"region":{"top_left_x":120,"top_left_y":1422,"width":1814,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61552b01aa9a42b088e6f6a7cfc0211d","type":"text","conversion_output":true,"text":"real world settings, \\({ }^{40-42}\\) and the mechanisms by which EEG-guidance could decrease postoperative delirium","text_display":" real world settings, \\({ }^{40-42}\\) and the mechanisms by which EEG-guidance could decrease postoperative delirium","confidence":1,"confidence_rate":1},{"cnt":[[120,1470],[1893,1470],[1893,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":1773,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcc1d8bf0267443697d6675b8c57ef64","type":"text","conversion_output":true,"text":"have not been clarified. In the United States, the American Society of Anesthesiologists in its most recent","text_display":" have not been clarified. In the United States, the American Society of Anesthesiologists in its most recent","confidence":1,"confidence_rate":1},{"cnt":[[120,1512],[1828,1512],[1828,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":1709,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"718320bc4f704002bcb44ca88d490ee7","type":"text","conversion_output":true,"text":"guidelines on brain monitoring does not recommend EEG monitoring as standard care for any patient","text_display":" guidelines on brain monitoring does not recommend EEG monitoring as standard care for any patient","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[120,1555],[1893,1555],[1893,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1773,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2b20e91df3a84cb6b6511d5859df5878","type":"text","conversion_output":true,"text":"population, procedure or anesthetic technique. \\({ }^{43}\\) A pragmatic, randomized clinical trial would address this","text_display":" population, procedure or anesthetic technique. \\({ }^{43}\\) A pragmatic, randomized clinical trial would address this","confidence":0.8857421875,"confidence_rate":0.9990059914403244},{"cnt":[[120,1601],[1914,1601],[1914,1644],[120,1644]],"region":{"top_left_x":120,"top_left_y":1600,"width":1795,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffb6afdc261c4bbb88d787c003718018","type":"text","conversion_output":true,"text":"controversy and could help to inform the standard of care going forward. The plausibility for EEG-guidance","text_display":" controversy and could help to inform the standard of care going forward. The plausibility for EEG-guidance","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[120,1644],[1983,1644],[1983,1687],[120,1687]],"region":{"top_left_x":120,"top_left_y":1643,"width":1864,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef93215d91f54151b92993a86c7dc8aa","type":"text","conversion_output":true,"text":"preventing postoperative delirium is that it might help practitioners to avoid excessive anesthetic administration","text_display":" preventing postoperative delirium is that it might help practitioners to avoid excessive anesthetic administration","confidence":1,"confidence_rate":1},{"cnt":[[120,1687],[1927,1687],[1927,1732],[120,1732]],"region":{"top_left_x":120,"top_left_y":1686,"width":1808,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4186d8f4919d41019d2f3f3b6748e2e1","type":"text","conversion_output":true,"text":"to vulnerable patients. \\({ }^{44}\\) During general anesthesia, BIS values <30 are usually reflective of periods of EEG","text_display":" to vulnerable patients. \\({ }^{44}\\) During general anesthesia, BIS values <30 are usually reflective of periods of EEG","confidence":0.7019221934024245,"confidence_rate":0.997149773527738},{"cnt":[[120,1729],[1895,1729],[1895,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1729,"width":1775,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9be552b8c8ba4a2c95fc08906c8e0ea3","type":"text","conversion_output":true,"text":"burst suppression, \\({ }^{45,46}\\) which is often indicative of excessively deep anesthesia (See Figure 1). One study","text_display":" burst suppression, \\({ }^{45,46}\\) which is often indicative of excessively deep anesthesia (See Figure 1). One study","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1833,1775],[1833,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1713,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da72ba4b4b17488086f92a7e6c4c02d7","type":"text","conversion_output":true,"text":"found a specific association between low BIS values and postoperative delirium, and the investigators","text_display":" found a specific association between low BIS values and postoperative delirium, and the investigators","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1897,1818],[1897,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":1778,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"608876dd18094e0184482bec8b2d9313","type":"text","conversion_output":true,"text":"hypothesized that burst suppression could be linked to postoperative delirium. \\({ }^{28}\\) An observational study in","text_display":" hypothesized that burst suppression could be linked to postoperative delirium. \\({ }^{28}\\) An observational study in","confidence":1,"confidence_rate":1},{"cnt":[[120,1863],[1953,1863],[1953,1906],[120,1906]],"region":{"top_left_x":120,"top_left_y":1862,"width":1833,"height":44},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"05d283f11dcc41449557ba41ef43cc2f","type":"text","conversion_output":true,"text":"cardiac surgery patients reported an association between intraoperative burst suppression and postoperative","text_display":" cardiac surgery patients reported an association between intraoperative burst suppression and 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BIS values have sometimes been shown to be associated with intermediate","text_display":" EEG burst suppression and low BIS values have sometimes been shown to be associated with intermediate","confidence":1,"confidence_rate":1},{"cnt":[[120,1989],[1914,1989],[1914,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1989,"width":1795,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"61d5f4a290d940ea919075e64487c433","type":"text","conversion_output":true,"text":"term mortality after surgery and critical illness. \\({ }^{31-36,49,50}\\) The proposed Electroencephalography Guidance of","text_display":" term mortality after surgery and critical illness. \\({ }^{31-36,49,50}\\) The proposed Electroencephalography Guidance of","confidence":0.94482421875,"confidence_rate":0.9995460520200122},{"cnt":[[120,2037],[1916,2037],[1916,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1797,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eba22ba98de460da5214c8bd1b0f4ed","type":"text","conversion_output":true,"text":"Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study is designed as a parallel group, pragmatic,","text_display":" Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study is designed as a parallel group, pragmatic,","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[120,2080],[1962,2080],[1962,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1842,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5abe69fb651e4a849e1d4ee5fca297a9","type":"text","conversion_output":true,"text":"superiority trial to test whether a simple EEG-guided 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2)}","confidence":1,"confidence_rate":1},{"cnt":[[116,200],[1970,200],[1970,247],[116,247]],"region":{"top_left_x":116,"top_left_y":199,"width":1855,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d6b9176a194096b5ad90579547eedf","type":"text","conversion_output":true,"text":"The Human Research Protection Office at Washington University School of Medicine has approved the study.","text_display":"\n\nThe Human Research Protection Office at Washington University School of Medicine has approved the study.","confidence":1,"confidence_rate":1},{"cnt":[[116,245],[1912,245],[1912,290],[116,290]],"region":{"top_left_x":116,"top_left_y":244,"width":1797,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"899166630f354a7c8dd50d565cc61c12","type":"text","conversion_output":true,"text":"This protocol, which details the design of the ENGAGES study, includes all the elements elaborated in the","text_display":" This protocol, which details the design of the ENGAGES study, includes all the elements elaborated in the","confidence":1,"confidence_rate":1},{"cnt":[[116,288],[1936,288],[1936,335],[116,335]],"region":{"top_left_x":116,"top_left_y":287,"width":1820,"height":49},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc1d8ee9c2484b538d62ccc7417d0f4c","type":"text","conversion_output":true,"text":"SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist. \\({ }^{51,52}\\) The ENGAGES","text_display":" SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist. \\({ }^{51,52}\\) The 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This hospital is an academic medical center","text_display":" elective major surgery at Barnes Jewish Hospital, St. Louis, MO. This hospital is an academic medical center","confidence":1,"confidence_rate":1},{"cnt":[[116,421],[1968,421],[1968,466],[116,466]],"region":{"top_left_x":116,"top_left_y":421,"width":1852,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c844eb05a4141ba9e5ea7de67e348c4","type":"text","conversion_output":true,"text":"in the Midwestern United States, which is affiliated to Washington University School of Medicine and serves a","text_display":" in the Midwestern United States, which is affiliated to Washington University School of Medicine and serves a","confidence":1,"confidence_rate":1},{"cnt":[[116,464],[1884,464],[1884,509],[116,509]],"region":{"top_left_x":116,"top_left_y":464,"width":1769,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf59dbe1c0974cc4b8a64fd11cd31b5a","type":"text","conversion_output":true,"text":"diverse range of patients in St. Louis and its environs. 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Surgical patients","confidence":1,"confidence_rate":1},{"cnt":[[116,552],[1867,552],[1867,597],[116,597]],"region":{"top_left_x":116,"top_left_y":552,"width":1751,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee7494c4bc1644a6b0c534a6a5273cd7","type":"text","conversion_output":true,"text":"might also be enrolled on hospital wards prior to their surgery. Participants will be randomly assigned to","text_display":" might also be enrolled on hospital wards prior to their surgery. Participants will be randomly assigned to","confidence":1,"confidence_rate":1},{"cnt":[[116,595],[1858,595],[1858,642],[116,642]],"region":{"top_left_x":116,"top_left_y":595,"width":1743,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3768cbf2b2d54014b294d916f1c01506","type":"text","conversion_output":true,"text":"receive the electroencephalography-guided protocol or routine care. 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At Washington","confidence":1,"confidence_rate":1},{"cnt":[[116,769],[1962,769],[1962,814],[116,814]],"region":{"top_left_x":116,"top_left_y":769,"width":1846,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d699697419e34b88aab3dfb2c025b0f5","type":"text","conversion_output":true,"text":"University, surgical patients have been enrolled in the Systematic Assessment and Targeted Improvement of","text_display":" University, surgical patients have been enrolled in the Systematic Assessment and Targeted Improvement of","confidence":1,"confidence_rate":1},{"cnt":[[116,812],[1992,812],[1992,862],[116,862]],"region":{"top_left_x":116,"top_left_y":812,"width":1876,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8a83adad48184d468556ea84c51b563e","type":"text","conversion_output":true,"text":"Services Following Yearly Surgical Outcomes Surveys (SATISFY-SOS - NCT02032030) study since 2012. For","text_display":" Services Following Yearly Surgical Outcomes Surveys (SATISFY-SOS - NCT02032030) study since 2012. For","confidence":0.9985356330871582,"confidence_rate":0.9999861751885265},{"cnt":[[116,855],[1893,855],[1893,904],[116,904]],"region":{"top_left_x":116,"top_left_y":855,"width":1777,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"307ca6d9bbef4fe7b7a7ec54fbb424be","type":"text","conversion_output":true,"text":"the exploratory aim 3 , there will be a prospective comorbidity-matched cohort study using the ENGAGES","text_display":" the exploratory aim 3 , there will be a prospective comorbidity-matched cohort study using the ENGAGES","confidence":0.81298828125,"confidence_rate":0.9981196012260702},{"cnt":[[116,902],[1974,902],[1974,947],[116,947]],"region":{"top_left_x":116,"top_left_y":902,"width":1859,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd6d085636c4479ab2c0d98f3d46436b","type":"text","conversion_output":true,"text":"clinical trial population and reference subjects from the ongoing SATISFY-SOS study. 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Patients 60","text_display":"\n\nThis study proposes to enroll 1,232 patients who are already enrolled in the SATISFY-SOS study. Patients 60","confidence":0.900486946105957,"confidence_rate":0.999080952313573},{"cnt":[[116,1349],[1944,1349],[1944,1394],[116,1394]],"region":{"top_left_x":116,"top_left_y":1349,"width":1829,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d60580646f248bcb8bd9e4f8d983ffc","type":"text","conversion_output":true,"text":"years old and older, who are competent to provide informed consent and who are undergoing major elective","text_display":" years old and older, who are competent to provide informed consent and who are undergoing major elective","confidence":1,"confidence_rate":1},{"cnt":[[116,1392],[1916,1392],[1916,1437],[116,1437]],"region":{"top_left_x":116,"top_left_y":1392,"width":1801,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f6509018b2b04757a45135f197c244fa","type":"text","conversion_output":true,"text":"surgery under general anesthesia with a potent volatile anesthetic agent that requires a minimum stay of 2","text_display":" surgery under general anesthesia with a potent volatile anesthetic agent that requires a minimum stay of 2","confidence":1,"confidence_rate":1},{"cnt":[[116,1435],[1841,1435],[1841,1482],[116,1482]],"region":{"top_left_x":116,"top_left_y":1435,"width":1726,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ff550048e2948318146397ea9cd0d7d","type":"text","conversion_output":true,"text":"days postoperatively (e.g., open cardiac surgery, open thoracic surgery, major vascular surgery, intra-","text_display":" days postoperatively (e.g., open cardiac surgery, open thoracic surgery, major vascular surgery, intra","confidence":0.99951171875,"confidence_rate":0.9999954777833909},{"cnt":[[116,1480],[1970,1480],[1970,1525],[116,1525]],"region":{"top_left_x":116,"top_left_y":1480,"width":1855,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f45ae4b793cf49f29ab87b6318e3df9e","type":"text","conversion_output":true,"text":"abdominal surgery, open gynecologic surgery, open urologic surgery, major orthopedic surgery, open hepato-","text_display":"abdominal surgery, open gynecologic surgery, open urologic surgery, major orthopedic surgery, open hepato","confidence":1,"confidence_rate":1},{"cnt":[[116,1523],[1944,1523],[1944,1571],[116,1571]],"region":{"top_left_x":116,"top_left_y":1523,"width":1829,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87f5decd1a5e469cbbddcdf31ae644d6","type":"text","conversion_output":true,"text":"biliary surgery and major ear, nose and throat surgery) will be eligible for inclusion. 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Neurosurgical procedures will be excluded as surgery on the","text_display":" exclusions and therefore maximum applicability. Neurosurgical procedures will be excluded as surgery on the","confidence":1,"confidence_rate":1},{"cnt":[[116,1654],[1888,1654],[1888,1704],[116,1704]],"region":{"top_left_x":116,"top_left_y":1654,"width":1773,"height":50},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cf7b55544c84ea1a3ddd51547a4cd8f","type":"text","conversion_output":true,"text":"brain can confound the outcome (postoperative delirium). We will also exclude patients with preoperative","text_display":" brain can confound the outcome (postoperative delirium). 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Patients with a history of intraoperative awareness during","confidence":1,"confidence_rate":1},{"cnt":[[116,1783],[1966,1783],[1966,1833],[116,1833]],"region":{"top_left_x":116,"top_left_y":1783,"width":1850,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"763654a76eb3426a87e961c948409997","type":"text","conversion_output":true,"text":"intended general anesthesia will also be excluded. \\({ }^{53}\\) Patients will be excluded if, prior to their index surgery, a","text_display":" intended general anesthesia will also be excluded. \\({ }^{53}\\) Patients will be excluded if, prior to their index surgery, a","confidence":1,"confidence_rate":1},{"cnt":[[116,1830],[1867,1830],[1867,1876],[116,1876]],"region":{"top_left_x":116,"top_left_y":1830,"width":1751,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33f2845898c64db6898cb8dd2a19b355","type":"text","conversion_output":true,"text":"second surgery is planned to occur within five days after the index surgery. Figure 3 outlines the flow of","text_display":" second surgery is planned to occur within five days after the index surgery. Figure 3 outlines the flow of","confidence":1,"confidence_rate":1},{"cnt":[[116,1873],[737,1873],[737,1921],[116,1921]],"region":{"top_left_x":116,"top_left_y":1873,"width":621,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57a5262bd75842278da8bd2e7e423d6f","type":"text","conversion_output":true,"text":"participants in the ENGAGES study.","text_display":" participants in the ENGAGES study.","confidence":1,"confidence_rate":1},{"cnt":[[116,1959],[621,1959],[621,2009],[116,2009]],"region":{"top_left_x":116,"top_left_y":1959,"width":505,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bc1406112354524852e4151f37ad14f","type":"section_header","conversion_output":false,"children_ids":["dbf46ad9c1174d68bf3cddec03d1951d"],"text":"","text_display":""},{"cnt":[[120,1962],[617,1962],[617,2009],[120,2009]],"region":{"top_left_x":120,"top_left_y":1961,"width":497,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dbf46ad9c1174d68bf3cddec03d1951d","type":"text","conversion_output":true,"parent_id":"0bc1406112354524852e4151f37ad14f","text":"Figure 3: Flow of participants","text_display":"\n\n\\section*{Figure 3: Flow of participants}","confidence":0.99853515625,"confidence_rate":0.9999581175147387},{"cnt":[[120,2093],[337,2093],[337,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2092,"width":218,"height":33},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7be55213b7a840968197a4aadc8c5c0c","type":"text","conversion_output":true,"text":"Recruitment","text_display":"\n\nRecruitment","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-14","page":14,"lines":[{"cnt":[[120,159],[1989,159],[1989,204],[120,204]],"region":{"top_left_x":120,"top_left_y":158,"width":1870,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c4e3f65917a94114ae87fdaa189cbeae","type":"text","conversion_output":true,"text":"to the pilot phase of the ENGAGES trial during the first year. In years 2-4 an accrual rate of 300 to 400 patients","text_display":"\nto the pilot phase of the ENGAGES trial during the first year. In years 2-4 an accrual rate of 300 to 400 patients","confidence":0.7242555618286133,"confidence_rate":0.9974224399238677},{"cnt":[[120,202],[1949,202],[1949,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1829,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09f1068aedb34b42aec9b675df153e08","type":"text","conversion_output":true,"text":"per year is anticipated. To maximize efficiency, data from the pilot will be included in the main study. \\({ }^{54}\\) In this","text_display":" per year is anticipated. To maximize efficiency, data from the pilot will be included in the main study. \\({ }^{54}\\) In this","confidence":0.99951171875,"confidence_rate":0.9999962430801487},{"cnt":[[120,245],[1940,245],[1940,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1821,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8719383b944a4d41bf34c34b2c443fe2","type":"text","conversion_output":true,"text":"pilot cohort, practical aspects of the trial's conduct will be evaluated. These include the feasibility of enrolling","text_display":" pilot cohort, practical aspects of the trial's conduct will be evaluated. These include the feasibility of enrolling","confidence":0.98193359375,"confidence_rate":0.9998493370005062},{"cnt":[[120,290],[1949,290],[1949,333],[120,333]],"region":{"top_left_x":120,"top_left_y":290,"width":1829,"height":44},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8177b5eee514ba889788c57bd00b301","type":"text","conversion_output":true,"text":"adequate numbers of patients in the preoperative assessment clinic; the ability of researchers to conduct the","text_display":" adequate numbers of patients in the preoperative assessment clinic; the ability of researchers to conduct the","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,335],[1931,335],[1931,380],[120,380]],"region":{"top_left_x":120,"top_left_y":335,"width":1812,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7636e220bdf40a9b95ea5b108eca1f1","type":"text","conversion_output":true,"text":"baseline preoperative assessments; the demonstration of retrieval of complete perioperative data (including","text_display":" baseline preoperative assessments; the demonstration of retrieval of complete perioperative data (including","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1813,378],[1813,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1694,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b0ffb38a54e43b495f2b2972cf5312f","type":"text","conversion_output":true,"text":"repeated measures of EEG-derived parameters) from the electronic medical record; successful daily","text_display":" repeated measures of EEG-derived parameters) from the electronic medical record; successful daily","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1927,421],[1927,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1808,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9808426107cc45f1ac03d1d315681a5b","type":"text","conversion_output":true,"text":"postoperative delirium assessments until postoperative day 5 or hospital discharge; for patients that remain","text_display":" postoperative delirium assessments until postoperative day 5 or hospital discharge; for patients that remain","confidence":1,"confidence_rate":1},{"cnt":[[120,466],[1914,466],[1914,509],[120,509]],"region":{"top_left_x":120,"top_left_y":466,"width":1795,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82eb230e2998468797990da8abda23a2","type":"text","conversion_output":true,"text":"delirious at day 5 they will be assessed until they return to baseline or until postoperative day 10, and near","text_display":" delirious at day 5 they will be assessed until they return to baseline or until postoperative day 10, and near","confidence":0.96435546875,"confidence_rate":0.9996924599372263},{"cnt":[[120,507],[1089,507],[1089,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":970,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"233536ca30ba48cc8c6f0bec163e05b4","type":"text","conversion_output":true,"text":"complete (>80\\%) 30-day patient reported outcomes data.","text_display":" complete (>80\\%) 30-day patient reported outcomes data.","confidence":0.99853515625,"confidence_rate":0.9999751542462456},{"cnt":[[122,597],[1927,597],[1927,640],[122,640]],"region":{"top_left_x":122,"top_left_y":597,"width":1806,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20f1872eede04b42a9313426adc31c1c","type":"text","conversion_output":true,"text":"Based on data from previous large clinical trials completed at our site, we expect the study population to be","text_display":"\n\nBased on data from previous large clinical trials completed at our site, we expect the study population to be","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[1962,640],[1962,685],[120,685]],"region":{"top_left_x":120,"top_left_y":640,"width":1842,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e758fe6384f4dd1a33a5f6423dd041a","type":"text","conversion_output":true,"text":"largely gender-balanced and representative of our environs. In two of our previous studies, we enrolled 6,700","text_display":" largely gender-balanced and representative of our environs. In two of our previous studies, we enrolled 6,700","confidence":0.5771484375,"confidence_rate":0.9951900629731582},{"cnt":[[120,683],[1921,683],[1921,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1801,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c491168d2b904243a8775ceaff776b0b","type":"text","conversion_output":true,"text":"patients in St. Louis, Missouri. Results showed slightly higher enrollment of males versus females ( \\(55 \\%\\) vs.","text_display":" patients in St. Louis, Missouri. Results showed slightly higher enrollment of males versus females ( \\(55 \\%\\) vs.","confidence":0.92626953125,"confidence_rate":0.9993399591622959},{"cnt":[[120,726],[1906,726],[1906,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1786,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"64faf7e0a6f94704a7e44a5445454b22","type":"text","conversion_output":true,"text":"\\(45 \\%\\) ), and racial demographics of approximately \\(80 \\%\\) white and \\(20 \\%\\) black or other. \\({ }^{40,41}\\) These results are","text_display":" \\(45 \\%\\) ), and racial demographics of approximately \\(80 \\%\\) white and \\(20 \\%\\) black or other. \\({ }^{40,41}\\) These results are","confidence":0.99560546875,"confidence_rate":0.9999647668960209},{"cnt":[[120,769],[1987,769],[1987,816],[120,816]],"region":{"top_left_x":120,"top_left_y":769,"width":1868,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a3ae13ebee7405eb9500abef7aade67","type":"text","conversion_output":true,"text":"generally representative of the population in metropolitan St. Louis and surrounding regions where the majority","text_display":" generally representative of the population in metropolitan St. Louis and surrounding regions where the majority","confidence":1,"confidence_rate":1},{"cnt":[[120,859],[120,812],[1904,814],[1904,862]],"region":{"top_left_x":120,"top_left_y":812,"width":1784,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"78d80c1f4b2f483f9efc51ab42d3d697","type":"text","conversion_output":true,"text":"of our patients reside. Based on 2011 census data, median household income and education levels of the","text_display":" of our patients reside. Based on 2011 census data, median household income and education levels of the","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1966,855],[1966,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1846,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb4b80108ef14122becb6decf8fcc3d7","type":"text","conversion_output":true,"text":"population of St. Louis metropolis are representative of the national average. The ENGAGES Study will enroll","text_display":" population of St. Louis metropolis are representative of the national average. The ENGAGES Study will enroll","confidence":0.89599609375,"confidence_rate":0.9990286205401662},{"cnt":[[120,902],[1807,902],[1807,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1687,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8979237d8eb34e5dbf937c0c239aa170","type":"text","conversion_output":true,"text":"patients older than 60 . Older patients constitute a vulnerable population and have often been under-","text_display":" patients older than 60 . Older patients constitute a vulnerable population and have often been under","confidence":0.96484375,"confidence_rate":0.9996717134588174},{"cnt":[[120,945],[1996,945],[1996,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1876,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69568a16265e4662b5eb2d5a25283c9e","type":"text","conversion_output":true,"text":"represented in clinical research. We anticipate that the patients enrolled in the ENGAGES Study will be broadly","text_display":"represented in clinical research. We anticipate that the patients enrolled in the ENGAGES Study will be broadly","confidence":0.8955585956573486,"confidence_rate":0.9990495241767705},{"cnt":[[120,988],[1944,988],[1944,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1825,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"29deb2d676de4c40ac678358514a0186","type":"text","conversion_output":true,"text":"representative of the older adult population of the United States, recognizing that certain demographics (e.g.","text_display":" representative of the older adult population of the United States, recognizing that certain demographics (e.g.","confidence":0.98974609375,"confidence_rate":0.999910379323065},{"cnt":[[120,1031],[1987,1031],[1987,1079],[120,1079]],"region":{"top_left_x":120,"top_left_y":1031,"width":1868,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"743648ba1cef4ec7b190e0800c35b00e","type":"text","conversion_output":true,"text":"Hispanic) are under-represented in St. Louis. The follow-up period after randomization is approximately 1 year.","text_display":" Hispanic) are under-represented in St. Louis. The follow-up period after randomization is approximately 1 year.","confidence":1,"confidence_rate":1},{"cnt":[[116,1113],[604,1113],[604,1164],[116,1164]],"region":{"top_left_x":116,"top_left_y":1112,"width":488,"height":53},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c900332fe9894be0b6c216a3271fe1af","type":"section_header","conversion_output":false,"children_ids":["d47df08d89f34aafa435be7b3673f00b"],"text":"","text_display":""},{"cnt":[[120,1117],[604,1117],[604,1162],[120,1162]],"region":{"top_left_x":120,"top_left_y":1117,"width":484,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d47df08d89f34aafa435be7b3673f00b","type":"text","conversion_output":true,"parent_id":"c900332fe9894be0b6c216a3271fe1af","text":"Randomization and Blinding","text_display":"\n\n\\section*{Randomization and Blinding}","confidence":1,"confidence_rate":1},{"cnt":[[120,1160],[1949,1160],[1949,1207],[120,1207]],"region":{"top_left_x":120,"top_left_y":1160,"width":1829,"height":48},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fff347d934af4cb2b0a17d9a876e1729","type":"text","conversion_output":true,"text":"Randomization will be performed at the patient level using computer-generated assignment. Eligible patients","text_display":"\n\nRandomization will be performed at the patient level using computer-generated assignment. Eligible patients","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,1205],[1586,1205],[1586,1250],[120,1250]],"region":{"top_left_x":120,"top_left_y":1205,"width":1466,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fea73e596ff64ad9952f58a55e038168","type":"text","conversion_output":true,"text":"who provided written informed consent will be randomized to receive the intraoperative","text_display":" who provided written informed consent will be randomized to receive the intraoperative","confidence":0.9990234375,"confidence_rate":0.9999892633582115},{"cnt":[[120,1248],[1944,1248],[1944,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1248,"width":1825,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82eef9078f694154b754d7b1fbd2ef7e","type":"text","conversion_output":true,"text":"electroencephalography-guided protocol or routine care. In order to ensure that there is not major imbalance","text_display":" electroencephalography-guided protocol or routine care. In order to ensure that there is not major imbalance","confidence":1,"confidence_rate":1},{"cnt":[[120,1293],[1934,1293],[1934,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1814,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60aa363d20304e9a84c943f481abc0b6","type":"text","conversion_output":true,"text":"between group assignments with respect to history of falls and cardiac surgery, subjects will be randomized","text_display":" between group assignments with respect to history of falls and cardiac surgery, subjects will be randomized","confidence":1,"confidence_rate":1},{"cnt":[[120,1336],[1921,1336],[1921,1381],[120,1381]],"region":{"top_left_x":120,"top_left_y":1336,"width":1801,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cad340df8a3a44d9b8675232fd4fddea","type":"text","conversion_output":true,"text":"\\((1: 1)\\) between the EEG-guided and routine care groups in blocks of 20 within these four strata (i.e., cardiac","text_display":" \\((1: 1)\\) between the EEG-guided and routine care groups in blocks of 20 within these four strata (i.e., cardiac","confidence":0.9453125,"confidence_rate":0.9995110785321785},{"cnt":[[120,1379],[1944,1379],[1944,1424],[120,1424]],"region":{"top_left_x":120,"top_left_y":1379,"width":1825,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0ab9c5ffd55d42238f594f444d652007","type":"text","conversion_output":true,"text":"surgery with a history of falls within 6 months, cardiac surgery without a history of falls within 6 months, non-","text_display":" surgery with a history of falls within 6 months, cardiac surgery without a history of falls within 6 months, non","confidence":0.994140625,"confidence_rate":0.9999526091190398},{"cnt":[[120,1422],[1992,1422],[1992,1467],[120,1467]],"region":{"top_left_x":120,"top_left_y":1422,"width":1872,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2e85f6e8da349528c3818c5091d6821","type":"text","conversion_output":true,"text":"cardiac surgery with a history of falls within 6 months; and non-cardiac surgery without a history of falls within 6","text_display":"cardiac surgery with a history of falls within 6 months; and non-cardiac surgery without a history of falls within 6","confidence":0.99951171875,"confidence_rate":0.9999960292721264},{"cnt":[[120,1465],[1953,1465],[1953,1512],[120,1512]],"region":{"top_left_x":120,"top_left_y":1465,"width":1833,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"501748d25e544520afb4063747baacad","type":"text","conversion_output":true,"text":"months). Trained members of the research team will enroll participants and will implement the assignment of","text_display":" months). Trained members of the research team will enroll participants and will implement the assignment of","confidence":1,"confidence_rate":1},{"cnt":[[120,1510],[1962,1510],[1962,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1510,"width":1842,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7cab816295849d98b00d5bc505c7874","type":"text","conversion_output":true,"text":"participants to the EEG-guided or usual care protocols. Group assignment will be revealed to members of the","text_display":" participants to the EEG-guided or usual care protocols. Group assignment will be revealed to members of the","confidence":1,"confidence_rate":1},{"cnt":[[120,1555],[1992,1555],[1992,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1872,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c5aa4258c1a04e1fa058eefe35ff42cd","type":"text","conversion_output":true,"text":"anesthetic team only when the patient enters the operating room by opening a sequentially numbered, opaque,","text_display":" anesthetic team only when the patient enters the operating room by opening a sequentially numbered, opaque,","confidence":1,"confidence_rate":1},{"cnt":[[120,1598],[1949,1598],[1949,1644],[120,1644]],"region":{"top_left_x":120,"top_left_y":1598,"width":1829,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3014a5ee6ad24857a23f81d4f59a3197","type":"text","conversion_output":true,"text":"sealed envelope in a sequence generated by one of the study's data analysts. Patients and their families will","text_display":" sealed envelope in a sequence generated by one of the study's data analysts. Patients and their families will","confidence":1,"confidence_rate":1},{"cnt":[[120,1641],[1936,1641],[1936,1687],[120,1687]],"region":{"top_left_x":120,"top_left_y":1641,"width":1816,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9553e1d835bc44019842c9faf177c0d0","type":"text","conversion_output":true,"text":"be blinded to group allocation and different members of the research team will assist with the intervention in","text_display":" be blinded to group allocation and different members of the research team will assist with the intervention in","confidence":1,"confidence_rate":1},{"cnt":[[120,1684],[1783,1684],[1783,1729],[120,1729]],"region":{"top_left_x":120,"top_left_y":1684,"width":1664,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e185eaf5bef4018b43ede174420c696","type":"text","conversion_output":true,"text":"the operating room (will not be blinded to the intervention) from those conducting the postoperative","text_display":" the operating room (will not be blinded to the intervention) from those conducting the postoperative","confidence":1,"confidence_rate":1},{"cnt":[[120,1727],[1979,1727],[1979,1775],[120,1775]],"region":{"top_left_x":120,"top_left_y":1727,"width":1859,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e67cf468f2cd4756bdf03914eb21fbc0","type":"text","conversion_output":true,"text":"assessments (will be blinded to the intervention). \\({ }^{51,52}\\) To reduce predictability of a random sequence, details of","text_display":" assessments (will be blinded to the intervention). \\({ }^{51,52}\\) To reduce predictability of a random sequence, details of","confidence":1,"confidence_rate":1},{"cnt":[[120,1772],[1897,1772],[1897,1818],[120,1818]],"region":{"top_left_x":120,"top_left_y":1772,"width":1778,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a18165b49f146cfb9b8c08985bc2d15","type":"text","conversion_output":true,"text":"patients already randomized and prior group assignments will be recorded in a separate document that is","text_display":" patients already randomized and prior group assignments will be recorded in a separate document that is","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1285,1818],[1285,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":1165,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"668e2747735e43e3a489724cc2f13ea4","type":"text","conversion_output":true,"text":"unavailable to those who enroll participants and assign interventions.","text_display":" unavailable to those who enroll participants and assign interventions.","confidence":1,"confidence_rate":1},{"cnt":[[116,1899],[1059,1899],[1059,1953],[116,1953]],"region":{"top_left_x":116,"top_left_y":1899,"width":944,"height":54},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0239006e9c94b11b1c340a973c0350c","type":"section_header","conversion_output":false,"children_ids":["18a6aa56e69c4800b3fd8ab2a1640005"],"text":"","text_display":""},{"cnt":[[120,1904],[1057,1904],[1057,1949],[120,1949]],"region":{"top_left_x":120,"top_left_y":1903,"width":938,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"18a6aa56e69c4800b3fd8ab2a1640005","type":"text","conversion_output":true,"parent_id":"e0239006e9c94b11b1c340a973c0350c","text":"Primary Intervention - EEG-guided Anesthetic Protocol","text_display":"\n\n\\section*{Primary Intervention - EEG-guided Anesthetic Protocol}","confidence":1,"confidence_rate":1},{"cnt":[[120,1946],[1835,1946],[1835,1994],[120,1994]],"region":{"top_left_x":120,"top_left_y":1946,"width":1715,"height":48},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1fc36ce88fcf49d09ab1eb107cfc35af","type":"text","conversion_output":true,"text":"The primary intervention to which patients will be randomized in this study is a pragmatic EEG-guided","text_display":"\n\nThe primary intervention to which patients will be randomized in this study is a pragmatic EEG-guided","confidence":1,"confidence_rate":1},{"cnt":[[120,1989],[1970,1989],[1970,2037],[120,2037]],"region":{"top_left_x":120,"top_left_y":1989,"width":1851,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2a3e76f7f0904c2a8396258d0ef47376","type":"text","conversion_output":true,"text":"anesthetic protocol (See Appendix). All anesthesia practitioners will receive a targeted educational session on","text_display":" anesthetic protocol (See Appendix). All anesthesia practitioners will receive a targeted educational session on","confidence":1,"confidence_rate":1},{"cnt":[[120,2035],[1936,2035],[1936,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2034,"width":1816,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f5338e7fe914d5a94582d9bc66fc80f","type":"text","conversion_output":true,"text":"recognition of EEG patterns typically occurring during general anesthesia. The content will be similar to that","text_display":" recognition of EEG patterns typically occurring during general anesthesia. The content will be similar to that","confidence":1,"confidence_rate":1},{"cnt":[[120,2080],[1910,2080],[1910,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1790,"height":46},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d26344d1d49f400db896f96af958c5ea","type":"text","conversion_output":true,"text":"described in an article where we demonstrated that anesthesiologists could estimate BIS (processed EEG","text_display":" described in an article where we demonstrated that anesthesiologists could estimate BIS (processed EEG","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-15","page":15,"lines":[{"cnt":[[120,157],[1904,157],[1904,204],[120,204]],"region":{"top_left_x":120,"top_left_y":156,"width":1784,"height":49},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"727218371d664b0dbb68b6a07c9a7a03","type":"text","conversion_output":true,"text":"1). The occurrence of burst suppression is the chief trigger for decreasing anesthetic administration in this","text_display":"\n1). The occurrence of burst suppression is the chief trigger for decreasing anesthetic administration in this","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[116,202],[1996,202],[1996,247],[116,247]],"region":{"top_left_x":116,"top_left_y":201,"width":1880,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"65d83ae2d2e94aba8c71027ffbb3deff","type":"text","conversion_output":true,"text":"protocol. An audible low-BIS alarm will be set at a threshold of 40, as there is an increased likelihood of epochs","text_display":" protocol. An audible low-BIS alarm will be set at a threshold of 40, as there is an increased likelihood of epochs","confidence":0.9794921875,"confidence_rate":0.9998258889604521},{"cnt":[[116,292],[116,241],[1992,243],[1992,294]],"region":{"top_left_x":115,"top_left_y":240,"width":1877,"height":55},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5e8a15073c5042ec8d314b25110204f1","type":"text","conversion_output":true,"text":"of EEG burst suppression below this value. \\({ }^{45}\\) BIS values less than 40 will be a secondary trigger for decreasing","text_display":" of EEG burst suppression below this value. \\({ }^{45}\\) BIS values less than 40 will be a secondary trigger for decreasing","confidence":0.99658203125,"confidence_rate":0.9999736632441295},{"cnt":[[116,288],[1835,288],[1835,337],[116,337]],"region":{"top_left_x":116,"top_left_y":287,"width":1719,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e16e98f160614ea3b53c1daf98c47581","type":"text","conversion_output":true,"text":"anesthetic administration. Importantly, the EEG-guided protocol is suggestive rather than prescriptive.","text_display":" anesthetic administration. Importantly, the EEG-guided protocol is suggestive rather than prescriptive.","confidence":1,"confidence_rate":1},{"cnt":[[116,331],[1981,331],[1981,380],[116,380]],"region":{"top_left_x":116,"top_left_y":330,"width":1865,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ad7fed0d1a444117890a29c638854727","type":"text","conversion_output":true,"text":"Clinicians should exercise judgment and might intentionally deviate from the protocol depending on the clinical","text_display":" Clinicians should exercise judgment and might intentionally deviate from the protocol depending on the clinical","confidence":1,"confidence_rate":1},{"cnt":[[116,374],[1867,374],[1867,423],[116,423]],"region":{"top_left_x":116,"top_left_y":373,"width":1751,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"93961a7c5892492e83e9a722f1ef753e","type":"text","conversion_output":true,"text":"situation. In both groups there will be an audible alarm for low volatile anesthetic agent (at 0.3 minimum","text_display":" situation. In both groups there will be an audible alarm for low volatile anesthetic agent (at 0.3 minimum","confidence":0.99853515625,"confidence_rate":0.9999871411556362},{"cnt":[[116,417],[1931,417],[1931,466],[116,466]],"region":{"top_left_x":116,"top_left_y":416,"width":1816,"height":51},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8cf5633383da4ce9a5b29193b21dd71b","type":"text","conversion_output":true,"text":"alveolar concentration or at the clinician's discretion), which is standard practice at our institution to prevent","text_display":" alveolar concentration or at the clinician's discretion), which is standard practice at our institution to prevent","confidence":0.9990234375,"confidence_rate":0.9999917896164967},{"cnt":[[116,464],[1989,464],[1989,509],[116,509]],"region":{"top_left_x":116,"top_left_y":464,"width":1874,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"84d89650e3b444e7b591d172f00475f2","type":"text","conversion_output":true,"text":"intraoperative awareness. BIS EEG sensors will also be applied to patients in the control group for the purpose","text_display":" intraoperative awareness. BIS EEG sensors will also be applied to patients in the control group for the purpose","confidence":1,"confidence_rate":1},{"cnt":[[116,507],[1936,507],[1936,552],[116,552]],"region":{"top_left_x":116,"top_left_y":507,"width":1820,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0167c15291b34d29b2689c51d1e48288","type":"text","conversion_output":true,"text":"of data comparisons between groups, but when a patient is assigned to the control arm, practitioners will be","text_display":" of data comparisons between groups, but when a patient is assigned to the control arm, practitioners will be","confidence":1,"confidence_rate":1},{"cnt":[[116,550],[1841,550],[1841,597],[116,597]],"region":{"top_left_x":116,"top_left_y":550,"width":1726,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"828cd0bd2f4448de9dfa2de4e42ce007","type":"text","conversion_output":true,"text":"blinded to all the EEG and BIS parameters, and will only see the signal quality index (SQI) of the EEG","text_display":" blinded to all the EEG and BIS parameters, and will only see the signal quality index (SQI) of the EEG","confidence":1,"confidence_rate":1},{"cnt":[[116,593],[1888,593],[1888,642],[116,642]],"region":{"top_left_x":116,"top_left_y":592,"width":1773,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be17fb950d5c4d5986ee2969352e1876","type":"text","conversion_output":true,"text":"montage (Figure 5). EEG monitoring may continue to be acquired via continuous recordings of EEG, eye","text_display":" montage (Figure 5). EEG monitoring may continue to be acquired via continuous recordings of EEG, eye","confidence":1,"confidence_rate":1},{"cnt":[[116,638],[1946,638],[1946,685],[116,685]],"region":{"top_left_x":116,"top_left_y":638,"width":1831,"height":48},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"959fbacbc62c47a380dc4badc4c3b9b5","type":"text","conversion_output":true,"text":"movements, and chin muscle activity for patients that are admitted to the ICU and step-down wards, or if the","text_display":" movements, and chin muscle activity for patients that are admitted to the ICU and step-down wards, or if the","confidence":1,"confidence_rate":1},{"cnt":[[116,683],[1966,683],[1966,728],[116,728]],"region":{"top_left_x":116,"top_left_y":683,"width":1850,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fac7bdfdce47430c9cc55778094d8f51","type":"text","conversion_output":true,"text":"hospital room allows. Patients and research assistants assessing the study outcome measures (e.g., delirium","text_display":" hospital room allows. Patients and research assistants assessing the study outcome measures (e.g., delirium","confidence":1,"confidence_rate":1},{"cnt":[[116,726],[1098,726],[1098,776],[116,776]],"region":{"top_left_x":116,"top_left_y":726,"width":982,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"43364307434444828583e5b82f70df39","type":"text","conversion_output":true,"text":"assessments) will be blinded to the allocated intervention.","text_display":" assessments) will be blinded to the allocated intervention.","confidence":1,"confidence_rate":1},{"cnt":[[110,846],[2002,846],[2002,1175],[110,1175]],"region":{"top_left_x":109,"top_left_y":846,"width":1894,"height":330},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"348c8fcad8c046af8a2bd8bb23fc83dc","type":"figure_label","conversion_output":false,"children_ids":["5ffffe5254944887b0928ea08a00a5dc","f16e2478080b482eaa16cfcee14ac4ec","6201667a40f44db6a486ab3c1126cfbd","c0b7730c8b6f446b8983bbfb20ffb6a2","c8d4a4dc8419437a9e2d0e759a3cd57e","4e38b814766a4da9a874faa9e054df97","57d148db4c354656969e5647c08089ce"],"text":"","text_display":""},{"cnt":[[116,855],[1629,855],[1629,904],[116,904]],"region":{"top_left_x":116,"top_left_y":855,"width":1513,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ffffe5254944887b0928ea08a00a5dc","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"Figure 4: The anesthesia monitor is configured for the EEG-guided arm such that the raw","text_display":"\n\nFigure 4: The anesthesia monitor is configured for the EEG-guided arm such that the raw","confidence":1,"confidence_rate":1},{"cnt":[[116,898],[1966,898],[1966,947],[116,947]],"region":{"top_left_x":116,"top_left_y":898,"width":1850,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f16e2478080b482eaa16cfcee14ac4ec","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"electroencephalograph (EEG) waveform as well as the non-proprietary numerical values are displayed by the","text_display":" electroencephalograph (EEG) waveform as well as the non-proprietary numerical values are displayed by the","confidence":1,"confidence_rate":1},{"cnt":[[116,945],[1938,945],[1938,990],[116,990]],"region":{"top_left_x":116,"top_left_y":945,"width":1822,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6201667a40f44db6a486ab3c1126cfbd","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"monitor, including the burst suppression ratio (SR) and the spectral edge frequency (SEF). The EEG filter is","text_display":" monitor, including the burst suppression ratio (SR) and the spectral edge frequency (SEF). The EEG filter is","confidence":1,"confidence_rate":1},{"cnt":[[116,988],[1992,988],[1992,1033],[116,1033]],"region":{"top_left_x":116,"top_left_y":988,"width":1876,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0b7730c8b6f446b8983bbfb20ffb6a2","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"turned off so the low frequency slow delta waves (with a frequency of about 0.5 Hz .) are clearly visible. Turning","text_display":" turned off so the low frequency slow delta waves (with a frequency of about 0.5 Hz .) are clearly visible. Turning","confidence":1,"confidence_rate":1},{"cnt":[[116,1031],[1983,1031],[1983,1079],[116,1079]],"region":{"top_left_x":116,"top_left_y":1031,"width":1868,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8d4a4dc8419437a9e2d0e759a3cd57e","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"off the filter allows EEG waves \\(<2 Hz\\) to be seen. The filter is a bandpass filter from 2 Hz to 70 Hz with a notch","text_display":" off the filter allows EEG waves \\(<2 Hz\\) to be seen. The filter is a bandpass filter from 2 Hz to 70 Hz with a notch","confidence":0.99951171875,"confidence_rate":0.9999963278225461},{"cnt":[[116,1074],[1858,1074],[1858,1124],[116,1124]],"region":{"top_left_x":116,"top_left_y":1074,"width":1743,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e38b814766a4da9a874faa9e054df97","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"to eliminate 60 Hz alternating current electrical noise. With the filter off, the system has a bandwidth of","text_display":" to eliminate 60 Hz alternating current electrical noise. With the filter off, the system has a bandwidth of","confidence":1,"confidence_rate":1},{"cnt":[[116,1119],[694,1119],[694,1167],[116,1167]],"region":{"top_left_x":116,"top_left_y":1119,"width":578,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57d148db4c354656969e5647c08089ce","type":"text","conversion_output":true,"parent_id":"348c8fcad8c046af8a2bd8bb23fc83dc","text":"approximately 0.25 Hz to 100 Hz .","text_display":" approximately 0.25 Hz to 100 Hz .","confidence":0.9931640625,"confidence_rate":0.9998571058446989},{"cnt":[[112,1203],[1949,1203],[1949,1304],[112,1304]],"region":{"top_left_x":111,"top_left_y":1203,"width":1838,"height":102},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6a157fa18de48698ed4cb445c71df9d","type":"figure_label","conversion_output":false,"children_ids":["17ec1440fc31493aad2f41299476b9fc","45bd536fe7cc46ff8e170de85a2b63bf"],"text":"","text_display":""},{"cnt":[[120,1207],[1940,1207],[1940,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1821,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17ec1440fc31493aad2f41299476b9fc","type":"text","conversion_output":true,"parent_id":"b6a157fa18de48698ed4cb445c71df9d","text":"Figure 5: The anesthesia monitor is configured for the control arm such all the EEG and BIS parameters are","text_display":"\n\nFigure 5: The anesthesia monitor is configured for the control arm such all the EEG and BIS parameters are","confidence":1,"confidence_rate":1},{"cnt":[[116,1250],[1429,1250],[1429,1300],[116,1300]],"region":{"top_left_x":116,"top_left_y":1250,"width":1313,"height":50},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"45bd536fe7cc46ff8e170de85a2b63bf","type":"text","conversion_output":true,"parent_id":"b6a157fa18de48698ed4cb445c71df9d","text":"hidden, and only the signal quality index (SQI) of the EEG montage is visible.","text_display":" hidden, and only the signal quality index (SQI) of the EEG montage is visible.","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-16","page":16,"lines":[{"cnt":[[120,202],[1033,202],[1033,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":914,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3e1630a850e34b77b68c25ff3651bbb7","type":"text","conversion_output":true,"text":"Ensure practitioner fidelity to the EEG-guided protocol","text_display":"\n\nEnsure practitioner fidelity to the EEG-guided protocol","confidence":1,"confidence_rate":1},{"cnt":[[120,245],[1927,245],[1927,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1808,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4acfe3e8adfa4c8c9f90f0c1190d5648","type":"text","conversion_output":true,"text":"In order for any monitor to alter clinical practice, clinicians must be able to glean useful information from the","text_display":"\nIn order for any monitor to alter clinical practice, clinicians must be able to glean useful information from the","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1983,288],[1983,335],[120,335]],"region":{"top_left_x":120,"top_left_y":287,"width":1864,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e184c05c5b4a43bbb239d34cd698f672","type":"text","conversion_output":true,"text":"monitor and should be motivated to make decisions based on that information. One of the limitations regarding","text_display":" monitor and should be motivated to make decisions based on that information. One of the limitations regarding","confidence":1,"confidence_rate":1},{"cnt":[[120,333],[1785,333],[1785,380],[120,380]],"region":{"top_left_x":120,"top_left_y":333,"width":1666,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"88a6cdb97b4e4ced8246c2a66f438c83","type":"text","conversion_output":true,"text":"EEG guidance of anesthesia is that teaching on electroencephalography is currently limited in both","text_display":" EEG guidance of anesthesia is that teaching on electroencephalography is currently limited in both","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1970,378],[1970,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1851,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46cd9fb9d58e44b38c0b4de9756cebd6","type":"text","conversion_output":true,"text":"anesthesiology residencies and in nurse anesthesia training programs. Given this, it is unsurprising that EEG-","text_display":" anesthesiology residencies and in nurse anesthesia training programs. Given this, it is unsurprising that EEG","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1944,421],[1944,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1825,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"870b7f138d994ba98fe4c35422145493","type":"text","conversion_output":true,"text":"based monitors have not been incorporated into routine anesthetic practice. Our research group published a","text_display":"based monitors have not been incorporated into routine anesthetic practice. Our research group published a","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1992,464],[1992,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1872,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"552fa3a26dae4594a8d9975f94fe4e31","type":"text","conversion_output":true,"text":"study showing that with a focused training session, anesthesiologists could learn to appreciate some of the key","text_display":" study showing that with a focused training session, anesthesiologists could learn to appreciate some of the key","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1895,507],[1895,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1775,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5886e96fa1a34381974be58b6787afc5","type":"text","conversion_output":true,"text":"EEG changes that occur with general anesthesia. \\({ }^{55}\\) We demonstrated that clinicians could learn relatively","text_display":" EEG changes that occur with general anesthesia. \\({ }^{55}\\) We demonstrated that clinicians could learn relatively","confidence":1,"confidence_rate":1},{"cnt":[[120,552],[1919,552],[1919,595],[120,595]],"region":{"top_left_x":120,"top_left_y":552,"width":1799,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4722ce1b6b144935ba659f0d777ae964","type":"text","conversion_output":true,"text":"rapidly to integrate clinical context with EEG waveform information and could even accurately estimate BIS","text_display":" rapidly to integrate clinical context with EEG waveform information and could even accurately estimate BIS","confidence":1,"confidence_rate":1},{"cnt":[[120,593],[1858,593],[1858,640],[120,640]],"region":{"top_left_x":120,"top_left_y":592,"width":1739,"height":49},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b9ea6bc88484277b9607cbdf47ecc74","type":"text","conversion_output":true,"text":"values - an index derived via computer-based processing of the raw EEG signal. \\({ }^{55}\\) With initiation of the","text_display":" values - an index derived via computer-based processing of the raw EEG signal. \\({ }^{55}\\) With initiation of the","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[1781,640],[1781,683],[120,683]],"region":{"top_left_x":120,"top_left_y":640,"width":1662,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d1ca87042b654144a7abb730669e4b45","type":"text","conversion_output":true,"text":"ENGAGES study, we launched a training module on a non-profit international educational website,","text_display":" ENGAGES study, we launched a training module on a non-profit international educational website,","confidence":0.9990234375,"confidence_rate":0.999990229651252},{"cnt":[[120,683],[1919,683],[1919,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1799,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"90c091899dc4411d8d9dd4dcc218f8c0","type":"text","conversion_output":true,"text":"International Consortium for Electroencephalograph Training of Anesthesia Practitioners (www.icetap.org),","text_display":" International Consortium for Electroencephalograph Training of Anesthesia Practitioners (www.icetap.org),","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1843,726],[1843,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1724,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0cf9dcfc2f747ba8c657fad727bf00a","type":"text","conversion_output":true,"text":"titled \"EEG Waveforms and Depth of Anesthesia\". \\({ }^{56}\\) Key to the success of the ENGAGES study will be","text_display":" titled \"EEG Waveforms and Depth of Anesthesia\". \\({ }^{56}\\) Key to the success of the ENGAGES study will be","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1921,769],[1921,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1801,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7be1e5e6a87b4b4aa5eeb0cb999f48d3","type":"text","conversion_output":true,"text":"educating anesthesia practitioners at our institution about the EEG waveform and how information from the","text_display":" educating anesthesia practitioners at our institution about the EEG waveform and how information from the","confidence":1,"confidence_rate":1},{"cnt":[[120,812],[1974,812],[1974,862],[120,862]],"region":{"top_left_x":120,"top_left_y":812,"width":1855,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60c7ac55980d43ddbb3d56bb91a791ad","type":"text","conversion_output":true,"text":"EEG can be useful in guiding anesthetic practice. Regarding EEG-derived parameters specifically, we capture","text_display":" EEG can be useful in guiding anesthetic practice. Regarding EEG-derived parameters specifically, we capture","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1867,855],[1867,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1747,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dde119b5ae95421baf89451e4ebe99af","type":"text","conversion_output":true,"text":"electronically both proprietary (e.g., BIS values) and non-proprietary (e.g., burst suppression ratio) data.","text_display":" electronically both proprietary (e.g., BIS values) and non-proprietary (e.g., burst suppression ratio) data.","confidence":0.9990234375,"confidence_rate":0.9999913536688149},{"cnt":[[120,902],[1953,902],[1953,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1833,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8baafd435a1a41339e12abde82987e68","type":"text","conversion_output":true,"text":"Therefore, we shall be able to ascertain from the phase 1 pilot study of 100 patients whether or not the EEG-","text_display":" Therefore, we shall be able to ascertain from the phase 1 pilot study of 100 patients whether or not the EEG","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[120,945],[1996,945],[1996,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1876,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b443415c4d1f4ecca8d08e78733503ac","type":"text","conversion_output":true,"text":"guided protocol alters anesthetic administration (e.g., measured concentrations of volatile anesthetic agents) or","text_display":"guided protocol alters anesthetic administration (e.g., measured concentrations of volatile anesthetic agents) or","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[122,988],[1861,988],[1861,1033],[122,1033]],"region":{"top_left_x":122,"top_left_y":988,"width":1739,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10e08f777917441cb25b7a26069360de","type":"text","conversion_output":true,"text":"EEG parameters (e.g., cumulative duration of EEG burst suppression). Given that the hypothesis of the","text_display":" EEG parameters (e.g., cumulative duration of EEG burst suppression). Given that the hypothesis of the","confidence":1,"confidence_rate":1},{"cnt":[[120,1031],[1871,1031],[1871,1076],[120,1076]],"region":{"top_left_x":120,"top_left_y":1031,"width":1752,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"772d8746a84c4f2f9bb3ee545841c02b","type":"text","conversion_output":true,"text":"ENGAGES study is that EEG guidance in the real world can alter anesthetic management, which in turn","text_display":" ENGAGES study is that EEG guidance in the real world can alter anesthetic management, which in turn","confidence":1,"confidence_rate":1},{"cnt":[[120,1076],[1914,1076],[1914,1121],[120,1121]],"region":{"top_left_x":120,"top_left_y":1076,"width":1795,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"222c7d7782d44169aafdbd2f46461e29","type":"text","conversion_output":true,"text":"prevents postoperative delirium, an essential proof of concept step in the pilot phase is to demonstrate our","text_display":" prevents postoperative delirium, an essential proof of concept step in the pilot phase is to demonstrate our","confidence":1,"confidence_rate":1},{"cnt":[[120,1121],[1846,1121],[1846,1167],[120,1167]],"region":{"top_left_x":120,"top_left_y":1121,"width":1726,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2d2071cee5a9427d81e0791b486577b1","type":"text","conversion_output":true,"text":"ability to alter anesthetic practice in a range of practitioners when they utilize the EEG-guided protocol.","text_display":" ability to alter anesthetic practice in a range of practitioners when they utilize the EEG-guided protocol.","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[116,1203],[1182,1203],[1182,1253],[116,1253]],"region":{"top_left_x":116,"top_left_y":1203,"width":1066,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1cdeebc17ccd412eb3290df549c55349","type":"section_header","conversion_output":false,"children_ids":["0a150f9c1ed142768af73bd2e6347737"],"text":"","text_display":""},{"cnt":[[120,1207],[1179,1207],[1179,1248],[120,1248]],"region":{"top_left_x":120,"top_left_y":1207,"width":1060,"height":42},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a150f9c1ed142768af73bd2e6347737","type":"text","conversion_output":true,"parent_id":"1cdeebc17ccd412eb3290df549c55349","text":"Secondary Intervention - Multi-Component Safety Intervention","text_display":"\n\n\\section*{Secondary Intervention - Multi-Component Safety Intervention}","confidence":0.97119140625,"confidence_rate":0.9995503825343109},{"cnt":[[120,1250],[1983,1250],[1983,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1864,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae16d5eaf5594a0d841c67a5d0ef1704","type":"text","conversion_output":true,"text":"Based on findings that multi-component non-pharmacological protocols can improve sleep, decrease episodes","text_display":"\n\nBased on findings that multi-component non-pharmacological protocols can improve sleep, decrease episodes","confidence":0.99853515625,"confidence_rate":0.9999866735644114},{"cnt":[[120,1293],[1957,1293],[1957,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1838,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a12953e00d764014af53b4d0dfaadd90","type":"text","conversion_output":true,"text":"of delirium, and improve outcomes, \\({ }^{20,57,58}\\) the ENGAGES study will implement a multi-component intervention","text_display":" of delirium, and improve outcomes, \\({ }^{20,57,58}\\) the ENGAGES study will implement a multi-component intervention","confidence":0.99951171875,"confidence_rate":0.9999959967252418},{"cnt":[[120,1336],[1955,1336],[1955,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1336,"width":1836,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4daa35f00a6247ea92484932c3192ed6","type":"text","conversion_output":true,"text":"including principles from the Hospital Elder Life Program \\({ }^{59,60}\\) for all patients enrolled in the study to attempt to","text_display":" including principles from the Hospital Elder Life Program \\({ }^{59,60}\\) for all patients enrolled in the study to attempt to","confidence":1,"confidence_rate":1},{"cnt":[[120,1379],[1927,1379],[1927,1429],[120,1429]],"region":{"top_left_x":120,"top_left_y":1379,"width":1808,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f66dc890f9f5418085c839a575d5d774","type":"text","conversion_output":true,"text":"prevent post-discharge falls and decrements in health-related quality of life. \\({ }^{20,57,58,61}\\) These outcomes will be","text_display":" prevent post-discharge falls and decrements in health-related quality of life. \\({ }^{20,57,58,61}\\) These outcomes will be","confidence":0.998046875,"confidence_rate":0.9999847264069878},{"cnt":[[120,1427],[1841,1427],[1841,1472],[120,1472]],"region":{"top_left_x":120,"top_left_y":1426,"width":1722,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4f82bdd87d874cee9d639a7f5cde25a2","type":"text","conversion_output":true,"text":"tracked in all patients in the ENGAGES study as they will also be enrolled in the SATISFY-SOS study.","text_display":" tracked in all patients in the ENGAGES study as they will also be enrolled in the SATISFY-SOS study.","confidence":0.99951171875,"confidence_rate":0.9999953485775026},{"cnt":[[120,1470],[1949,1470],[1949,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":1829,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ea13be868c943e3afe36c990bb7bc3f","type":"text","conversion_output":true,"text":"Likewise, these outcomes will be ascertained in a matched cohort of controls from the SATISFY-SOS cohort","text_display":" Likewise, these outcomes will be ascertained in a matched cohort of controls from the SATISFY-SOS cohort","confidence":1,"confidence_rate":1},{"cnt":[[120,1512],[1858,1512],[1858,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":1739,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"86cdda4dc5b846418bbdad87df9dcddf","type":"text","conversion_output":true,"text":"who will not be enrolled in the ENGAGES study. This will allow comparison in these outcomes between","text_display":" who will not be enrolled in the ENGAGES study. This will allow comparison in these outcomes between","confidence":0.9790825843811035,"confidence_rate":0.9997967583087438},{"cnt":[[120,1555],[1884,1555],[1884,1603],[120,1603]],"region":{"top_left_x":120,"top_left_y":1555,"width":1765,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db2823b9bbe4471ba3ce74a48d8c68b6","type":"text","conversion_output":true,"text":"patients receiving the multi-component safety intervention and matched controls (Aim 3 in Figure 2). The","text_display":" patients receiving the multi-component safety intervention and matched controls (Aim 3 in Figure 2). The","confidence":1,"confidence_rate":1},{"cnt":[[120,1601],[1979,1601],[1979,1646],[120,1646]],"region":{"top_left_x":120,"top_left_y":1600,"width":1859,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"030a412677df4f00a5253fcedb1f100d","type":"text","conversion_output":true,"text":"interventions, implemented mainly after hospital discharge, will include the following, as indicated: reduction of","text_display":" interventions, implemented mainly after hospital discharge, will include the following, as indicated: reduction of","confidence":1,"confidence_rate":1},{"cnt":[[120,1644],[1893,1644],[1893,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1643,"width":1773,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b338e83b0b0544de982890775e9c6a55","type":"text","conversion_output":true,"text":"psychoactive drugs; advice on non-pharmacological approaches to manage sleep, anxiety, and agitation;","text_display":" psychoactive drugs; advice on non-pharmacological approaches to manage sleep, anxiety, and agitation;","confidence":1,"confidence_rate":1},{"cnt":[[120,1689],[1742,1689],[1742,1734],[120,1734]],"region":{"top_left_x":120,"top_left_y":1688,"width":1623,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7176a8a51f8945e9a7418495d4114211","type":"text","conversion_output":true,"text":"involvement of family members in care, particularly for reorientation and prevention of self-harm;","text_display":" involvement of family members in care, particularly for reorientation and prevention of self-harm;","confidence":1,"confidence_rate":1},{"cnt":[[120,1732],[1923,1732],[1923,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1731,"width":1803,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d86566ad2d054ef4ab6b14a553183646","type":"text","conversion_output":true,"text":"encouragement of mobility and self-care; ensuring that, if needed, patients have glasses, hearing aids, and","text_display":" encouragement of mobility and self-care; ensuring that, if needed, patients have glasses, hearing aids, and","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1846,1775],[1846,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1726,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06bd856bb06c441b9e0eadbde0b7bf16","type":"text","conversion_output":true,"text":"dentures; home visits by occupational therapists; targeted home safety modifications; keeping patients","text_display":" dentures; home visits by occupational therapists; targeted home safety modifications; keeping patients","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1931,1818],[1931,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":1812,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"286b0b38ce94484991634fdbd03e65c3","type":"text","conversion_output":true,"text":"involved in their care; and communicating regularly with patients and their families. \\({ }^{20}\\) During the pilot phase,","text_display":" involved in their care; and communicating regularly with patients and their families. \\({ }^{20}\\) During the pilot phase,","confidence":0.9990234375,"confidence_rate":0.9999923068040193},{"cnt":[[120,1863],[1880,1863],[1880,1910],[120,1910]],"region":{"top_left_x":120,"top_left_y":1862,"width":1760,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a6f67ac6cff547638e5a6749c6c2c387","type":"text","conversion_output":true,"text":"patients and their family members will be called and questioned about their perception of the utility of the","text_display":" patients and their family members will be called and questioned about their perception of the utility of the","confidence":1,"confidence_rate":1},{"cnt":[[120,1908],[1025,1908],[1025,1949],[120,1949]],"region":{"top_left_x":120,"top_left_y":1907,"width":905,"height":42},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"862c5910b1fe49599ebb1453d1d62975","type":"text","conversion_output":true,"text":"educational resources and, if relevant, the home visit.","text_display":" educational resources and, if relevant, the home visit.","confidence":1,"confidence_rate":1},{"cnt":[[120,1994],[1951,1994],[1951,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":1831,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"35a3b93b17754ae1a99aea8d7ca02f58","type":"text","conversion_output":true,"text":"Preoperatively, at the time of providing informed consent for the ENGAGES study (but prior to randomization","text_display":"\n\nPreoperatively, at the time of providing informed consent for the ENGAGES study (but prior to randomization","confidence":1,"confidence_rate":1},{"cnt":[[120,2037],[1957,2037],[1957,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1838,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5aebe889a6b94a618e728a7eed707797","type":"text","conversion_output":true,"text":"for the primary intervention), all participants and their families will receive general information on delirium and","text_display":" for the primary intervention), all participants and their families will receive general information on delirium and","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[120,2080],[1876,2080],[1876,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1756,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e702444c5b7546faa14e85f6d3cdb862","type":"text","conversion_output":true,"text":"falls derived from the Hospital Elder Life Program \\({ }^{59,60}\\) and from the Agency for Healthcare and Research","text_display":" falls derived from the Hospital Elder Life Program \\({ }^{59,60}\\) and from the Agency for Healthcare and Research","confidence":0.9897651672363281,"confidence_rate":0.9999135535787005}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-17","page":17,"lines":[{"cnt":[[120,157],[1987,157],[1987,204],[120,204]],"region":{"top_left_x":120,"top_left_y":156,"width":1868,"height":49},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2770625fa7b140f7b3c754bb586298df","type":"text","conversion_output":true,"text":"and recommendations. \\({ }^{70}\\) Many of these targeted medications were highlighted in the recent American Geriatric","text_display":"\nand recommendations. \\({ }^{70}\\) Many of these targeted medications were highlighted in the recent American 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risk \\({ }^{71}\\) the research staff may","text_display":"\n\nBecause a history of falls in older adults is associated with increased fall risk \\({ }^{71}\\) the research staff may","confidence":0.99951171875,"confidence_rate":0.9999959967252418},{"cnt":[[120,333],[1861,333],[1861,380],[120,380]],"region":{"top_left_x":120,"top_left_y":333,"width":1741,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aad0a42257dc444fa7ce9b080f0dd62c","type":"text","conversion_output":true,"text":"recommend and provide (if acceptable to patients and if patients live <45 miles from the hospital) home","text_display":" recommend and provide (if acceptable to patients and if patients live <45 miles from the hospital) home","confidence":0.8395335674285889,"confidence_rate":0.9983817846299023},{"cnt":[[120,378],[1858,378],[1858,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1739,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4ae6a46797c4de8adb3d51bada01cd9","type":"text","conversion_output":true,"text":"occupational therapy visits that have the general aim of improving daily activity performance/safety and","text_display":" occupational therapy visits that have the general aim of improving daily activity performance/safety and","confidence":1,"confidence_rate":1},{"cnt":[[120,419],[1970,419],[1970,466],[120,466]],"region":{"top_left_x":120,"top_left_y":418,"width":1851,"height":49},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae6ae38e8f1949c09412876dc29c452a","type":"text","conversion_output":true,"text":"prevention of falls. Because delirium in older adults is associated with increased fall risk \\({ }^{72-76}\\) the research staff","text_display":" prevention of falls. Because delirium in older adults is associated with increased fall risk \\({ }^{72-76}\\) the research staff","confidence":0.9985356330871582,"confidence_rate":0.9999888982423376},{"cnt":[[120,464],[1914,464],[1914,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1795,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a420008370e4d3caaff934f6f7c912a","type":"text","conversion_output":true,"text":"will recommend that patients' families exercise increased vigilance when delirium features are noted in the","text_display":" will recommend that patients' families exercise increased vigilance when delirium features are noted in the","confidence":0.998046875,"confidence_rate":0.9999825444841725},{"cnt":[[120,507],[1929,507],[1929,554],[120,554]],"region":{"top_left_x":120,"top_left_y":507,"width":1810,"height":48},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ce71ca93bfe4b8fa83fc61dc6cb7dc8","type":"text","conversion_output":true,"text":"hospital or after hospital discharge. Patients and their families will also be reminded about the home safety","text_display":" hospital or after hospital discharge. Patients and their families will also be reminded about the home safety","confidence":1,"confidence_rate":1},{"cnt":[[120,552],[1888,552],[1888,597],[120,597]],"region":{"top_left_x":120,"top_left_y":552,"width":1769,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f07560f4ea7b469d948e62f4b91b7d5a","type":"text","conversion_output":true,"text":"assessment tool that they received at the time of enrollment (Appendix: See CDC Fall Safety Information","text_display":" assessment tool that they received at the time of enrollment (Appendix: See CDC Fall Safety Information","confidence":0.9951171875,"confidence_rate":0.9999546790605736},{"cnt":[[120,593],[251,593],[251,642],[120,642]],"region":{"top_left_x":120,"top_left_y":592,"width":132,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"794c70beb590477d89a772d4d370c492","type":"text","conversion_output":true,"text":"Sheet).","text_display":" Sheet).","confidence":1,"confidence_rate":1},{"cnt":[[116,722],[406,722],[406,771],[116,771]],"region":{"top_left_x":116,"top_left_y":721,"width":291,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"02aa79542da34e919c11d082aa4b3d9a","type":"section_header","conversion_output":false,"children_ids":["1aa0397eb17549d38596aeb60dbba7cb"],"text":"","text_display":""},{"cnt":[[120,726],[402,726],[402,767],[120,767]],"region":{"top_left_x":120,"top_left_y":726,"width":282,"height":41},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1aa0397eb17549d38596aeb60dbba7cb","type":"text","conversion_output":true,"parent_id":"02aa79542da34e919c11d082aa4b3d9a","text":"Data Collection","text_display":"\n\n\\section*{Data Collection}","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1869,769],[1869,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1750,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1ef5df76fc94a529eaf1806335f90b0","type":"text","conversion_output":true,"text":"Baseline assessment will take place at the CPAP clinic and include demographic information, a detailed","text_display":"\n\nBaseline assessment will take place at the CPAP clinic and include demographic information, a detailed","confidence":1,"confidence_rate":1},{"cnt":[[120,812],[1985,812],[1985,862],[120,862]],"region":{"top_left_x":120,"top_left_y":812,"width":1866,"height":50},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec268028a7e3419a90bd81be49c63f34","type":"text","conversion_output":true,"text":"medical history, physical examination, assessment of preoperative quality of life, and evaluation of falls history.","text_display":" medical history, physical examination, assessment of preoperative quality of life, and evaluation of falls history.","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1944,855],[1944,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1825,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a8ad3a6ff2f644d79f6c83a8204a81ac","type":"text","conversion_output":true,"text":"Delirium will be assessed daily in the postoperative period of the hospital stay. Data collected specifically for","text_display":" Delirium will be assessed daily in the postoperative period of the hospital stay. Data collected specifically for","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1953,902],[1953,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1833,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8b635e26c21a4b4092cb5a8d8d113898","type":"text","conversion_output":true,"text":"the ENGAGES study, such as the daily delirium assessments, will be entered into the Washington University","text_display":" the ENGAGES study, such as the daily delirium assessments, will be entered into the Washington University","confidence":1,"confidence_rate":1},{"cnt":[[120,941],[1962,941],[1962,990],[120,990]],"region":{"top_left_x":120,"top_left_y":941,"width":1842,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7ba4492995845988fea3c0b6e7cd954","type":"text","conversion_output":true,"text":"School of Medicine Research Electronic Data Capture (REDCap) application. \\({ }^{77}\\) In the ENGAGES study, EEG","text_display":" School of Medicine Research Electronic Data Capture (REDCap) application. \\({ }^{77}\\) In the ENGAGES study, EEG","confidence":0.998046875,"confidence_rate":0.9999832904401549},{"cnt":[[120,988],[1970,988],[1970,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1851,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a912ab748cae41b69dbf3478cf09fd8a","type":"text","conversion_output":true,"text":"data (including BIS values and EEG burst suppression durations) will be collected in the intervention group as","text_display":" data (including BIS values and EEG burst suppression durations) will be collected in the intervention group as","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[116,1031],[1940,1031],[1940,1076],[116,1076]],"region":{"top_left_x":116,"top_left_y":1031,"width":1825,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e5bb9305027a4cd0838998e9657ed3b3","type":"text","conversion_output":true,"text":"well as in the blinded control group. \\({ }^{36,50}\\) Furthermore, perioperative data (including repeated measures data)","text_display":" well as in the blinded control group. \\({ }^{36,50}\\) Furthermore, perioperative data (including repeated measures data)","confidence":1,"confidence_rate":1},{"cnt":[[118,1072],[1983,1072],[1983,1119],[118,1119]],"region":{"top_left_x":118,"top_left_y":1072,"width":1866,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fffd2137e7a04877930c671c48dab6e6","type":"text","conversion_output":true,"text":"will be retrieved from the hospital’s perioperative electronic medical record (Metavision by iMDsoft \\({ }^{\\text {® }}\\), Needham,","text_display":" will be retrieved from the hospital’s perioperative electronic medical record (Metavision by iMDsoft \\({ }^{\\text {® }}\\), Needham,","confidence":0.4226088523864746,"confidence_rate":0.9935449224028489},{"cnt":[[118,1117],[1936,1117],[1936,1167],[118,1167]],"region":{"top_left_x":118,"top_left_y":1117,"width":1818,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b966b4efcb84c5d8b05c67b9766c529","type":"text","conversion_output":true,"text":"MA). \\({ }^{36,41,53,78}\\) We are able routinely to capture high fidelity perioperative data from our MetaVision to an SQL","text_display":" MA). \\({ }^{36,41,53,78}\\) We are able routinely to capture high fidelity perioperative data from our MetaVision to an SQL","confidence":0.9887747764587402,"confidence_rate":0.9999111165342364},{"cnt":[[118,1164],[1953,1164],[1953,1210],[118,1210]],"region":{"top_left_x":118,"top_left_y":1164,"width":1835,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6003874b8f3c44fc8e2c7e687b724da1","type":"text","conversion_output":true,"text":"server (Microsoft, Redmond, WA) database. Routinely acquired data include detailed patient medical history,","text_display":" server (Microsoft, Redmond, WA) database. Routinely acquired data include detailed patient medical history,","confidence":1,"confidence_rate":1},{"cnt":[[118,1207],[1869,1207],[1869,1253],[118,1253]],"region":{"top_left_x":118,"top_left_y":1207,"width":1752,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d289c38d5f1409a822c90ef4381c4ab","type":"text","conversion_output":true,"text":"surgical history, specific patient risk factors, medications, Barthel Index, VR-12 quality of life data, Short","text_display":" surgical history, specific patient risk factors, medications, Barthel Index, VR-12 quality of life data, Short","confidence":1,"confidence_rate":1},{"cnt":[[120,1250],[1970,1250],[1970,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1851,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d55670f38f5140c89c0a2001eabc7d71","type":"text","conversion_output":true,"text":"Blessed Test, sleep apnea screening, laboratory data, intraoperative medications, physiological readings, and","text_display":" Blessed Test, sleep apnea screening, laboratory data, intraoperative medications, physiological readings, and","confidence":1,"confidence_rate":1},{"cnt":[[120,1293],[1800,1293],[1800,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1681,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33355cbdad7a4bc0a8d7c4d7df14d2ce","type":"text","conversion_output":true,"text":"postoperative recovery parameters. Olfaction might be assessed preoperatively with the Brief Smell","text_display":" postoperative recovery parameters. Olfaction might be assessed preoperatively with the Brief Smell","confidence":1,"confidence_rate":1},{"cnt":[[120,1336],[1981,1336],[1981,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1336,"width":1861,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77aa5175963f42a4a97f8439cda082e4","type":"text","conversion_output":true,"text":"Identification Test, as hyposmia has been identified as a risk factor for postoperative delirium. \\({ }^{79} All\\) the data for","text_display":" Identification Test, as hyposmia has been identified as a risk factor for postoperative delirium. \\({ }^{79} All\\) the data for","confidence":0.912682056427002,"confidence_rate":0.9993183839018877},{"cnt":[[120,1379],[1949,1379],[1949,1429],[120,1429]],"region":{"top_left_x":120,"top_left_y":1379,"width":1829,"height":50},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e116d348e04645248b36053f1bf53b84","type":"text","conversion_output":true,"text":"SATISFY-SOS are integrated from various data sources and are stored in a single data repository housed in","text_display":" SATISFY-SOS are integrated from various data sources and are stored in a single data repository housed in","confidence":1,"confidence_rate":1},{"cnt":[[120,1422],[1141,1422],[1141,1472],[120,1472]],"region":{"top_left_x":120,"top_left_y":1422,"width":1021,"height":50},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a40416baab58465998b944fa4d01964d","type":"text","conversion_output":true,"text":"the Department of Anesthesiology at Washington University.","text_display":" the Department of Anesthesiology at Washington University.","confidence":1,"confidence_rate":1},{"cnt":[[116,1508],[423,1508],[423,1560],[116,1560]],"region":{"top_left_x":116,"top_left_y":1508,"width":308,"height":52},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"551f53a184a040cdaf859a277e7fce97","type":"section_header","conversion_output":false,"children_ids":["5cb54901557045e8bf922eae22896f32"],"text":"","text_display":""},{"cnt":[[120,1512],[419,1512],[419,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":299,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5cb54901557045e8bf922eae22896f32","type":"text","conversion_output":true,"parent_id":"551f53a184a040cdaf859a277e7fce97","text":"Cognitive Testing","text_display":"\n\n\\section*{Cognitive Testing}","confidence":1,"confidence_rate":1},{"cnt":[[120,1555],[1826,1555],[1826,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1707,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f84375d3f9604154a3bdc52e729217ec","type":"text","conversion_output":true,"text":"When patients are assessed for delirium, structured cognitive appraisal is performed, which gives the","text_display":"\n\nWhen patients are assessed for delirium, structured cognitive appraisal is performed, which gives the","confidence":1,"confidence_rate":1},{"cnt":[[120,1598],[1940,1598],[1940,1644],[120,1644]],"region":{"top_left_x":120,"top_left_y":1598,"width":1821,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44d85fc7099c489e8755d3ec5be68801","type":"text","conversion_output":true,"text":"interviewer an opportunity to make observations that are used when scoring the CAM. In addition, as part of","text_display":" interviewer an opportunity to make observations that are used when scoring the CAM. In addition, as part of","confidence":1,"confidence_rate":1},{"cnt":[[120,1644],[1835,1644],[1835,1689],[120,1689]],"region":{"top_left_x":120,"top_left_y":1643,"width":1715,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00cd102a43824584bee595fd64e66c8b","type":"text","conversion_output":true,"text":"the routine preoperative assessment, patients will be screened for cognitive impairment with the AD-8","text_display":" the routine preoperative assessment, patients will be screened for cognitive impairment with the AD-8","confidence":1,"confidence_rate":1},{"cnt":[[120,1687],[1983,1687],[1983,1734],[120,1734]],"region":{"top_left_x":120,"top_left_y":1686,"width":1864,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aea54d00b74947c6b9019efe9b914d66","type":"text","conversion_output":true,"text":"dementia screen \\({ }^{80}\\) and with the Short Blessed Test. \\({ }^{81}\\) Tests from the cognitive battery of the NIH toolbox might","text_display":" dementia screen \\({ }^{80}\\) and with the Short Blessed Test. \\({ }^{81}\\) Tests from the cognitive battery of the NIH toolbox might","confidence":1,"confidence_rate":1},{"cnt":[[120,1729],[1850,1729],[1850,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1729,"width":1730,"height":48},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b6fdcb42c3524433ad35b5d1d7c7ff54","type":"text","conversion_output":true,"text":"also be incorporated in the baseline assessment. \\({ }^{82,83}\\) This computer based battery assesses Executive","text_display":" also be incorporated in the baseline assessment. \\({ }^{82,83}\\) This computer based battery assesses Executive","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1931,1775],[1931,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1812,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d337716a9ae347e3a451c677718c7218","type":"text","conversion_output":true,"text":"Function, Attention, Episodic Memory, Language, Processing Speed and Working Memory (See Appendix).","text_display":" Function, Attention, Episodic Memory, Language, Processing Speed and Working Memory (See Appendix).","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1867,1818],[1867,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":1747,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ef28a29c93b94de0ba31d84eb659e3ac","type":"text","conversion_output":true,"text":"Depending on time constraints, patients might complete a long form of the cognitive battery or a version","text_display":" Depending on time constraints, patients might complete a long form of the cognitive battery or a version","confidence":1,"confidence_rate":1},{"cnt":[[120,1861],[1962,1861],[1962,1908],[120,1908]],"region":{"top_left_x":120,"top_left_y":1860,"width":1842,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da0ee825bdb2461091c871cc46b67dc6","type":"text","conversion_output":true,"text":"focused on executive function, episodic memory and attention. Patients who prefer not to do computer based","text_display":" focused on executive function, episodic memory and attention. Patients who prefer not to do computer based","confidence":1,"confidence_rate":1},{"cnt":[[120,1904],[1940,1904],[1940,1951],[120,1951]],"region":{"top_left_x":120,"top_left_y":1903,"width":1821,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e53b914a95aa4857adc69f4104bc9b2a","type":"text","conversion_output":true,"text":"cognitive tests will be offered paper based cognitive tests (Trails A and B, and Stroop Color and Word Test).","text_display":" cognitive tests will be offered paper based cognitive tests (Trails A and B, and Stroop Color and Word Test).","confidence":1,"confidence_rate":1},{"cnt":[[120,1946],[1966,1946],[1966,1996],[120,1996]],"region":{"top_left_x":120,"top_left_y":1946,"width":1846,"height":50},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4afcc6fa324243628927e8e842a8edeb","type":"text","conversion_output":true,"text":"Impaired performance on preoperative cognitive tests is reportedly associated with postoperative delirium \\({ }^{84,85}\\),","text_display":" Impaired performance on preoperative cognitive tests is reportedly associated with postoperative delirium \\({ }^{84,85}\\),","confidence":0.994631290435791,"confidence_rate":0.9999579448462581},{"cnt":[[120,1989],[1962,1989],[1962,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1989,"width":1842,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1daf36a5a95545f1bdde29fb5750fb30","type":"text","conversion_output":true,"text":"and postoperative delirium has been found to be associated with persistent postoperative cognitive decline. \\({ }^{18}\\)","text_display":" and postoperative delirium has been found to be associated with persistent postoperative cognitive decline. \\({ }^{18}\\)","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[120,2037],[1833,2037],[1833,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1713,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"103f543e0bde43d580c356caaacd7edf","type":"text","conversion_output":true,"text":"Therefore, when patients are followed up postoperatively at thirty days, the Short Blessed Test will be","text_display":" Therefore, when patients are followed up postoperatively at thirty days, the Short Blessed Test will be","confidence":1,"confidence_rate":1},{"cnt":[[120,2080],[1962,2080],[1962,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1842,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14fef3eea0ee4036a0713edb6a861afc","type":"text","conversion_output":true,"text":"administered on the telephone. When patients are followed up postoperatively at one year, the Short Blessed","text_display":" administered on the telephone. When patients are followed up postoperatively at one year, the Short Blessed","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-18","page":18,"lines":[{"cnt":[[120,155],[1897,155],[1897,204],[120,204]],"region":{"top_left_x":120,"top_left_y":154,"width":1778,"height":51},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0c37c209d104eb3af56d0b4b2542271","type":"text","conversion_output":true,"text":"(hematocrit \\(<35 \\%\\) ), functional status, 6 months history of falls and the Barthel Index. \\({ }^{86}\\) In addition to these","text_display":"\n(hematocrit \\(<35 \\%\\) ), functional status, 6 months history of falls and the Barthel Index. \\({ }^{86}\\) In addition to these","confidence":0.99951171875,"confidence_rate":0.9999963000030714},{"cnt":[[120,198],[1964,198],[1964,247],[120,247]],"region":{"top_left_x":120,"top_left_y":197,"width":1844,"height":51},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0ee1f81ac1e47128b7ef6135a5b91ab","type":"text","conversion_output":true,"text":"measures, for the ENGAGES study we plan to measure grip strength and the Timed Up and Go (TUG) test. \\({ }^{86}\\)","text_display":" measures, for the ENGAGES study we plan to measure grip strength and the Timed Up and Go (TUG) test. \\({ }^{86}\\)","confidence":1,"confidence_rate":1},{"cnt":[[120,245],[1962,245],[1962,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1842,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c2617da25414c0a871ca3d26b21ca66","type":"text","conversion_output":true,"text":"Grip strength will also be assessed with three measurements in the dominant hand using a Jamar® handheld","text_display":" Grip strength will also be assessed with three measurements in the dominant hand using a Jamar® handheld","confidence":0.99853515625,"confidence_rate":0.9999865513043565},{"cnt":[[120,288],[1886,288],[1886,337],[120,337]],"region":{"top_left_x":120,"top_left_y":287,"width":1767,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0925fadbca44d17b21645681ca33609","type":"text","conversion_output":true,"text":"dynamometer (Lafayette Instruments, Lafayette, IN). \\({ }^{87}\\) Maximal grip strength will be selected for analysis.","text_display":" dynamometer (Lafayette Instruments, Lafayette, IN). \\({ }^{87}\\) Maximal grip strength will be selected for analysis.","confidence":1,"confidence_rate":1},{"cnt":[[116,374],[892,374],[892,425],[116,425]],"region":{"top_left_x":116,"top_left_y":373,"width":776,"height":53},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f33b61f9c6a34c60af241f7c5a24596c","type":"section_header","conversion_output":false,"children_ids":["ee89a78a6289455d820a69f4732064df"],"text":"","text_display":""},{"cnt":[[120,378],[887,378],[887,421],[120,421]],"region":{"top_left_x":120,"top_left_y":378,"width":768,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ee89a78a6289455d820a69f4732064df","type":"text","conversion_output":true,"parent_id":"f33b61f9c6a34c60af241f7c5a24596c","text":"Patients' Postoperative Health and Wellbeing","text_display":"\n\n\\section*{Patients' Postoperative Health and Wellbeing}","confidence":0.99951171875,"confidence_rate":0.9999900326925697},{"cnt":[[120,421],[1996,421],[1996,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1876,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdb19948423b45b0b5b58a03c25a6787","type":"text","conversion_output":true,"text":"All patients enrolled in the ENGAGES study will already have provided informed consent for the SATISFY-SOS","text_display":"\n\nAll patients enrolled in the ENGAGES study will already have provided informed consent for the SATISFY-SOS","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1944,464],[1944,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1825,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fbdb5fe358e74e6fa4bf0076351f4b43","type":"text","conversion_output":true,"text":"study. Using the SATISFY-SOS infrastructure, the ENGAGES study will track postoperative patient reported","text_display":" study. Using the SATISFY-SOS infrastructure, the ENGAGES study will track postoperative patient reported","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1940,507],[1940,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1821,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4a3616166daf44469bd16b22b83c5d73","type":"text","conversion_output":true,"text":"outcomes at approximately 1 month and at 1 year. Patient reported outcomes tracked include health-related","text_display":" outcomes at approximately 1 month and at 1 year. Patient reported outcomes tracked include health-related","confidence":0.9907269477844238,"confidence_rate":0.9999196901679238},{"cnt":[[120,552],[741,552],[741,595],[120,595]],"region":{"top_left_x":120,"top_left_y":552,"width":622,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ca8529f613a4019ba876678f695c90a","type":"text","conversion_output":true,"text":"quality of life and postoperative falls.","text_display":" quality of life and postoperative falls.","confidence":1,"confidence_rate":1},{"cnt":[[116,636],[462,636],[462,685],[116,685]],"region":{"top_left_x":116,"top_left_y":635,"width":346,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44d4282304ea44eaaa4bc276e6612094","type":"section_header","conversion_output":false,"children_ids":["d06a122456f54c919f183c2a89d638c6"],"text":"","text_display":""},{"cnt":[[120,640],[458,640],[458,681],[120,681]],"region":{"top_left_x":120,"top_left_y":640,"width":338,"height":42},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d06a122456f54c919f183c2a89d638c6","type":"text","conversion_output":true,"parent_id":"44d4282304ea44eaaa4bc276e6612094","text":"Outcome Measures","text_display":"\n\n\\section*{Outcome Measures}","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1081,726],[1081,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":961,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b735f825776a4f42a2714f44720f2869","type":"text","conversion_output":true,"text":"i) Incidence of Postoperative Delirium (Aim 1 in Figure 2)","text_display":"\ni) Incidence of Postoperative Delirium (Aim 1 in Figure 2)","confidence":1,"confidence_rate":1},{"cnt":[[122,769],[1927,769],[1927,814],[122,814]],"region":{"top_left_x":122,"top_left_y":769,"width":1806,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07e34852a9af440291839c07e01a6007","type":"text","conversion_output":true,"text":"Incident delirium is the primary outcome of the ENGAGES trial. A preoperative baseline assessment will be","text_display":"\n\nIncident delirium is the primary outcome of the ENGAGES trial. A preoperative baseline assessment will be","confidence":1,"confidence_rate":1},{"cnt":[[120,814],[1886,814],[1886,862],[120,862]],"region":{"top_left_x":120,"top_left_y":814,"width":1767,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d8e77c30f72f47b4a113e8120d30c955","type":"text","conversion_output":true,"text":"performed when patients are enrolled to participate in the ENGAGES study. Preoperative delirium is rare","text_display":" performed when patients are enrolled to participate in the ENGAGES study. Preoperative delirium is rare","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1957,855],[1957,902],[120,902]],"region":{"top_left_x":120,"top_left_y":855,"width":1838,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cbea31d91fc94f43ba928a579cc1ff8b","type":"text","conversion_output":true,"text":"before elective surgery and will exclude participation in the study. Postoperative delirium assessments will be","text_display":" before elective surgery and will exclude participation in the study. Postoperative delirium assessments will be","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1979,902],[1979,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1859,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"380044ff8eb641e583964dc8a5a23275","type":"text","conversion_output":true,"text":"performed when patients can be aroused sufficiently in order to be assessed for delirium (Richmond Agitation-","text_display":" performed when patients can be aroused sufficiently in order to be assessed for delirium (Richmond Agitation","confidence":0.985358476638794,"confidence_rate":0.9998706244368921},{"cnt":[[120,947],[1983,947],[1983,995],[120,995]],"region":{"top_left_x":120,"top_left_y":947,"width":1864,"height":48},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1f44f420db44b7e9af3d3b0a11758be","type":"text","conversion_output":true,"text":"Sedation Scale (RASS) > -4). Patients will be assessed for delirium once daily in the afternoon / evening. Each","text_display":"Sedation Scale (RASS) > -4). Patients will be assessed for delirium once daily in the afternoon / evening. Each","confidence":0.9946377224997605,"confidence_rate":0.9999536501594155},{"cnt":[[120,993],[1957,993],[1957,1042],[120,1042]],"region":{"top_left_x":120,"top_left_y":992,"width":1838,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a966b54e8b2a4220af62255fe910fd65","type":"text","conversion_output":true,"text":"patient will be assessed for delirium up to postoperative day 5 ; for patients that remain delirious at day 5 they","text_display":" patient will be assessed for delirium up to postoperative day 5 ; for patients that remain delirious at day 5 they","confidence":0.82421875,"confidence_rate":0.9984546408110865},{"cnt":[[120,1040],[1972,1040],[1972,1085],[120,1085]],"region":{"top_left_x":120,"top_left_y":1039,"width":1853,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"780ae3c9d3b2420a902dbcb0f8d4e780","type":"text","conversion_output":true,"text":"will be assessed until they return to baseline or until postoperative day 10, postoperative delirium typically first","text_display":" will be assessed until they return to baseline or until postoperative day 10, postoperative delirium typically first","confidence":0.99658203125,"confidence_rate":0.9999717043395896},{"cnt":[[120,1083],[1962,1083],[1962,1128],[120,1128]],"region":{"top_left_x":120,"top_left_y":1082,"width":1842,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b399b0edb1ce460a968ca06eba689388","type":"text","conversion_output":true,"text":"manifests \\(24-96\\) hours after surgery. Delirium will be diagnosed based on a combined approach consisting of","text_display":" manifests \\(24-96\\) hours after surgery. Delirium will be diagnosed based on a combined approach consisting of","confidence":0.763671875,"confidence_rate":0.9976377325813786},{"cnt":[[120,1126],[1921,1126],[1921,1171],[120,1171]],"region":{"top_left_x":120,"top_left_y":1125,"width":1801,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"815e0ec83fc64a04ba0d0d996cf2bd4a","type":"text","conversion_output":true,"text":"standardized daily Confusion Assessment Method (CAM) evaluations coupled with structured chart review.","text_display":" standardized daily Confusion Assessment Method (CAM) evaluations coupled with structured chart review.","confidence":1,"confidence_rate":1},{"cnt":[[120,1169],[1936,1169],[1936,1214],[120,1214]],"region":{"top_left_x":120,"top_left_y":1168,"width":1816,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd7df9dbb7084f82bc259b8407fd4702","type":"text","conversion_output":true,"text":"The CAM has been described as a viable tool to be used by non-psychiatrists for delirium detection. \\({ }^{21}\\) It has","text_display":" The CAM has been described as a viable tool to be used by non-psychiatrists for delirium detection. \\({ }^{21}\\) It has","confidence":1,"confidence_rate":1},{"cnt":[[120,1212],[1910,1212],[1910,1259],[120,1259]],"region":{"top_left_x":120,"top_left_y":1211,"width":1790,"height":48},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5592e442be9b4398b137ef43e6133e6a","type":"text","conversion_output":true,"text":"subsequently been validated in numerous studies, and has a sensitivity of \\(>94 \\%\\) and a specificity of \\(>89 \\%\\)","text_display":" subsequently been validated in numerous studies, and has a sensitivity of \\(>94 \\%\\) and a specificity of \\(>89 \\%\\)","confidence":0.99853515625,"confidence_rate":0.9999867936215969},{"cnt":[[120,1257],[1940,1257],[1940,1302],[120,1302]],"region":{"top_left_x":120,"top_left_y":1256,"width":1821,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"396f8d6869174ebba6f4451de0611cf7","type":"text","conversion_output":true,"text":"against a reference standard. \\({ }^{88}\\) Trained research team members who are blinded to treatment allocation will","text_display":" against a reference standard. \\({ }^{88}\\) Trained research team members who are blinded to treatment allocation will","confidence":1,"confidence_rate":1},{"cnt":[[120,1298],[1910,1298],[1910,1347],[120,1347]],"region":{"top_left_x":120,"top_left_y":1297,"width":1790,"height":51},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bcd1b37d61af493fad4297b645c2d19b","type":"text","conversion_output":true,"text":"assess patients for incident delirium (primary outcome) using the Confusion Assessment Method (CAM). \\({ }^{21}\\)","text_display":" assess patients for incident delirium (primary outcome) using the Confusion Assessment Method (CAM). \\({ }^{21}\\)","confidence":1,"confidence_rate":1},{"cnt":[[120,1345],[1962,1345],[1962,1390],[120,1390]],"region":{"top_left_x":120,"top_left_y":1344,"width":1842,"height":47},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cf713b1ba943478e9ce7e9695ed456eb","type":"text","conversion_output":true,"text":"Patients who are unable to speak (e.g., have a tracheal tube or tracheostomy) will instead be assessed using","text_display":" Patients who are unable to speak (e.g., have a tracheal tube or tracheostomy) will instead be assessed using","confidence":1,"confidence_rate":1},{"cnt":[[120,1388],[1876,1388],[1876,1433],[120,1433]],"region":{"top_left_x":120,"top_left_y":1387,"width":1756,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9d2a473f4fbe4ba9a8a0ccd1d16d2cbe","type":"text","conversion_output":true,"text":"the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) instrument. \\({ }^{89,90}\\) Both of these","text_display":" the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) instrument. \\({ }^{89,90}\\) Both of these","confidence":1,"confidence_rate":1},{"cnt":[[120,1431],[1944,1431],[1944,1476],[120,1476]],"region":{"top_left_x":120,"top_left_y":1430,"width":1825,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed3ac6a4624941a7aaf887b31db59be6","type":"text","conversion_output":true,"text":"methods (the CAM and the CAM-ICU) have been shown to be reliable and to have good agreement with the","text_display":" methods (the CAM and the CAM-ICU) have been shown to be reliable and to have good agreement with the","confidence":1,"confidence_rate":1},{"cnt":[[120,1474],[1861,1474],[1861,1521],[120,1521]],"region":{"top_left_x":120,"top_left_y":1473,"width":1741,"height":49},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"446aa5bd46904cbab9bc16e4d58f1aa4","type":"text","conversion_output":true,"text":"DSM-IV criteria for delirium. \\({ }^{90-92}\\) In addition to the CAM or the CAM-ICU, an independent trained clinical","text_display":" DSM-IV criteria for delirium. \\({ }^{90-92}\\) In addition to the CAM or the CAM-ICU, an independent trained clinical","confidence":0.9985356330871582,"confidence_rate":0.9999878889977525},{"cnt":[[120,1521],[1974,1521],[1974,1566],[120,1566]],"region":{"top_left_x":120,"top_left_y":1521,"width":1855,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"954358c1065e4b0ea6a6c1825b0d5882","type":"text","conversion_output":true,"text":"researcher, blinded to the CAM results, will conduct structured chart reviews to detect episodes of delirium. A","text_display":" researcher, blinded to the CAM results, will conduct structured chart reviews to detect episodes of delirium. A","confidence":1,"confidence_rate":1},{"cnt":[[120,1564],[1867,1564],[1867,1609],[120,1609]],"region":{"top_left_x":120,"top_left_y":1564,"width":1747,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9cd18e0073d64f6ea940f8c35d5c6855","type":"text","conversion_output":true,"text":"combined approach (CAM interview or CAM-ICU plus chart review) increases the sensitivity and retains","text_display":" combined approach (CAM interview or CAM-ICU plus chart review) increases the sensitivity and retains","confidence":1,"confidence_rate":1},{"cnt":[[120,1607],[1953,1607],[1953,1652],[120,1652]],"region":{"top_left_x":120,"top_left_y":1607,"width":1833,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7734e1770554698891b49870849c7e3","type":"text","conversion_output":true,"text":"specificity in detecting incident delirium. \\({ }^{93,94}\\) Therefore, either a positive clinical delirium assessment (CAM or","text_display":" specificity in detecting incident delirium. \\({ }^{93,94}\\) Therefore, either a positive clinical delirium assessment (CAM or","confidence":1,"confidence_rate":1},{"cnt":[[120,1646],[1876,1646],[1876,1695],[120,1695]],"region":{"top_left_x":120,"top_left_y":1645,"width":1756,"height":51},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8dc04da053fc401c9bfdc190e40079db","type":"text","conversion_output":true,"text":"CAM-ICU) or a positive assessment for delirium based on a validated, structured chart review \\({ }^{93,94}\\) will be","text_display":" CAM-ICU) or a positive assessment for delirium based on a validated, structured chart review \\({ }^{93,94}\\) will be","confidence":1,"confidence_rate":1},{"cnt":[[120,1693],[1953,1693],[1953,1740],[120,1740]],"region":{"top_left_x":120,"top_left_y":1692,"width":1833,"height":49},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5435cae24b6c466cb5c6f0729754f4af","type":"text","conversion_output":true,"text":"diagnostic of incident delirium in the ENGAGES trial. The use of the structured chart review will both improve","text_display":" diagnostic of incident delirium in the ENGAGES trial. The use of the structured chart review will both improve","confidence":1,"confidence_rate":1},{"cnt":[[120,1738],[1888,1738],[1888,1783],[120,1783]],"region":{"top_left_x":120,"top_left_y":1738,"width":1769,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6ed76b4e73284668b3b3ed8dc34f5175","type":"text","conversion_output":true,"text":"sensitive and contribute to the pragmatic aspects of this trial, since it will abstract incident delirium from a","text_display":" sensitive and contribute to the pragmatic aspects of this trial, since it will abstract incident delirium from a","confidence":1,"confidence_rate":1},{"cnt":[[120,1779],[1904,1779],[1904,1828],[120,1828]],"region":{"top_left_x":120,"top_left_y":1778,"width":1784,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9941982dec1410095a8cc753b5bd539","type":"text","conversion_output":true,"text":"routinely available source. The trial staff will undergo training on the chart review methodology by a skilled","text_display":" routinely available source. The trial staff will undergo training on the chart review methodology by a skilled","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,1826],[1210,1826],[1210,1871],[120,1871]],"region":{"top_left_x":120,"top_left_y":1826,"width":1090,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d497d9fe1664aad82ca55ee8fdd03d1","type":"text","conversion_output":true,"text":"chart reviewer under the supervision of Drs. Inouye and Schmitt.","text_display":" chart reviewer under the supervision of Drs. Inouye and Schmitt.","confidence":1,"confidence_rate":1},{"cnt":[[120,1910],[1992,1910],[1992,1957],[120,1957]],"region":{"top_left_x":120,"top_left_y":1909,"width":1872,"height":49},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1de90810a6ce4756893a5fe80a321f36","type":"text","conversion_output":true,"text":"The CAM assessment that will be used in the ENGAGES study was developed by Dr. Inouye and colleagues. \\({ }^{21}\\)","text_display":"\n\nThe CAM assessment that will be used in the ENGAGES study was developed by Dr. Inouye and colleagues. \\({ }^{21}\\)","confidence":0.9990236759185791,"confidence_rate":0.999991506114367},{"cnt":[[120,1955],[1957,1955],[1957,2000],[120,2000]],"region":{"top_left_x":120,"top_left_y":1955,"width":1838,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb44e9ec50804e20a913031f261441d4","type":"text","conversion_output":true,"text":"All ENGAGES CAM assessments will be performed by study team members who have undergone a rigorous","text_display":" All ENGAGES CAM assessments will be performed by study team members who have undergone a rigorous","confidence":0.99951171875,"confidence_rate":0.999995211771286},{"cnt":[[120,1998],[1992,1998],[1992,2047],[120,2047]],"region":{"top_left_x":120,"top_left_y":1998,"width":1872,"height":50},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74d65c151be641b6bb8fcc74bedc78e6","type":"text","conversion_output":true,"text":"training process. Several members of the research team participated in a full-day CAM training program led by","text_display":" training process. Several members of the research team participated in a full-day CAM training program led by","confidence":1,"confidence_rate":1},{"cnt":[[120,2041],[1901,2041],[1901,2090],[120,2090]],"region":{"top_left_x":120,"top_left_y":2041,"width":1782,"height":50},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bdc7a1af93a74678b23a0c240954eaae","type":"text","conversion_output":true,"text":"Dr. Inouye, the original creator of the instrument. \\({ }^{95}\\) Those who attended this initial training will oversee the","text_display":" Dr. Inouye, the original creator of the instrument. \\({ }^{95}\\) Those who attended this initial training will oversee the","confidence":1,"confidence_rate":1},{"cnt":[[120,2086],[1888,2086],[1888,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2086,"width":1769,"height":39},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3cb49df41a094de492eefe1021862983","type":"text","conversion_output":true,"text":"training of other team members. All trainees must demonstrate competence at conducting the structured","text_display":" training of other team members. All trainees must demonstrate competence at conducting the structured","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-19","page":19,"lines":[{"cnt":[[120,159],[1897,159],[1897,202],[120,202]],"region":{"top_left_x":120,"top_left_y":158,"width":1778,"height":44},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"63ca38a7580247d6a31f86195c30b98d","type":"text","conversion_output":true,"text":"assessments must view and rate nine videos of standard interviews of actors depicting delirious and non-","text_display":"\nassessments must view and rate nine videos of standard interviews of actors depicting delirious and non","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1949,202],[1949,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1829,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7444eef8d424e4bb2d8fd9b8c47f298","type":"text","conversion_output":true,"text":"delirious patients. This process will help to demonstrate the success of the training process and the extent to","text_display":"delirious patients. This process will help to demonstrate the success of the training process and the extent to","confidence":1,"confidence_rate":1},{"cnt":[[120,247],[1884,247],[1884,290],[120,290]],"region":{"top_left_x":120,"top_left_y":247,"width":1765,"height":44},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ce55d8db94b4b8d9d52d62b8f13c7af","type":"text","conversion_output":true,"text":"which researchers reproducibly score the CAM. To establish the reliability of delirium assessments in the","text_display":" which researchers reproducibly score the CAM. To establish the reliability of delirium assessments in the","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1919,288],[1919,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":1799,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab1b5daa62eb4647b4b68480aaf97f8f","type":"text","conversion_output":true,"text":"clinical setting, trained members of the research team will separately assess 30 patients not enrolled in the","text_display":" clinical setting, trained members of the research team will separately assess 30 patients not enrolled in the","confidence":1,"confidence_rate":1},{"cnt":[[122,335],[1824,335],[1824,380],[122,380]],"region":{"top_left_x":122,"top_left_y":335,"width":1703,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bef2fba102214dda999d76496ca72a29","type":"text","conversion_output":true,"text":"ENGAGES study at similar time points (e.g., within two hours of each other). These assessments will","text_display":" ENGAGES study at similar time points (e.g., within two hours of each other). These assessments will","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1979,378],[1979,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1859,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0b771fed18d4c3088e7c9bbcec52306","type":"text","conversion_output":true,"text":"determine the test-retest reliability of delirium assessments by the research team. This approach will provide >","text_display":" determine the test-retest reliability of delirium assessments by the research team. This approach will provide >","confidence":0.9853515625,"confidence_rate":0.9998738815839736},{"cnt":[[120,421],[1944,421],[1944,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1825,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b58bd891258e47579aeea0f52f9bf0b5","type":"text","conversion_output":true,"text":"\\(90 \\%\\) power to demonstrate a Kappa statistic of \\(>0.6\\), representing substantial or greater agreement between","text_display":" \\(90 \\%\\) power to demonstrate a Kappa statistic of \\(>0.6\\), representing substantial or greater agreement between","confidence":0.957988359112619,"confidence_rate":0.9996202521903833},{"cnt":[[120,462],[264,462],[264,505],[120,505]],"region":{"top_left_x":120,"top_left_y":461,"width":145,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74378abe94b442429826cf4d76ca771e","type":"text","conversion_output":true,"text":"raters. \\({ }^{96}\\)","text_display":" raters. \\({ }^{96}\\)","confidence":0.99951171875,"confidence_rate":0.9999767431038692},{"cnt":[[120,552],[1979,552],[1979,597],[120,597]],"region":{"top_left_x":120,"top_left_y":552,"width":1859,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7263fc0e71d040e49aa06014c28d19f3","type":"text","conversion_output":true,"text":"A structured process will be implemented to assess and ensure the quality of the delirium assessments. Every","text_display":"\n\nA structured process will be implemented to assess and ensure the quality of the delirium assessments. Every","confidence":1,"confidence_rate":1},{"cnt":[[120,597],[1949,597],[1949,642],[120,642]],"region":{"top_left_x":120,"top_left_y":597,"width":1829,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09523328b9dc4ff58ad5a49c3774be6d","type":"text","conversion_output":true,"text":"delirium assessment will be reviewed within three days with a fellow member of the research team to assess","text_display":" delirium assessment will be reviewed within three days with a fellow member of the research team to assess","confidence":0.9990234375,"confidence_rate":0.9999911978797494},{"cnt":[[120,640],[1953,640],[1953,685],[120,685]],"region":{"top_left_x":120,"top_left_y":640,"width":1833,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"76a07a4eaeee4d0a8d0a299fe124c847","type":"text","conversion_output":true,"text":"internal consistency of scoring and completeness. On a weekly basis, investigators at Washington University","text_display":" internal consistency of scoring and completeness. On a weekly basis, investigators at Washington University","confidence":1,"confidence_rate":1},{"cnt":[[120,683],[1876,683],[1876,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1756,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2623680c78824e29b9ead0f578f259f8","type":"text","conversion_output":true,"text":"will review all the delirium assessments, will address methodological inconsistencies, and will attempt to","text_display":" will review all the delirium assessments, will address methodological inconsistencies, and will attempt to","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1772,726],[1772,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1653,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a85b0dc728440d29b33f9021520745e","type":"text","conversion_output":true,"text":"resolve controversies. Monthly, there will be a teleconference including investigators from Hebrew","text_display":" resolve controversies. Monthly, there will be a teleconference including investigators from Hebrew","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1989,769],[1989,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1870,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ae0937652f7543bc92a6a1ea67e6cf13","type":"text","conversion_output":true,"text":"SeniorLife/Harvard University and from Washington University to review challenging delirium assessments and","text_display":" SeniorLife/Harvard University and from Washington University to review challenging delirium assessments and","confidence":1,"confidence_rate":1},{"cnt":[[120,812],[1957,812],[1957,862],[120,862]],"region":{"top_left_x":120,"top_left_y":812,"width":1838,"height":50},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df63c6e3861e4f8b8f1476c8d2b35796","type":"text","conversion_output":true,"text":"to ensure that the rigor of assessments remains appropriate. During these conferences, the need for focused","text_display":" to ensure that the rigor of assessments remains appropriate. During these conferences, the need for focused","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1510,855],[1510,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1391,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d557b068be7f4b6ca60d61ae6ebe033d","type":"text","conversion_output":true,"text":"and comprehensive refresher training in delirium assessment \\({ }^{95}\\) will be determined.","text_display":" and comprehensive refresher training in delirium assessment \\({ }^{95}\\) will be determined.","confidence":1,"confidence_rate":1},{"cnt":[[120,945],[1949,945],[1949,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1829,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3135515ff523424b9a4435620fd33c55","type":"text","conversion_output":true,"text":"If participants agree, these assessments may be videotaped for training and education of the research team.","text_display":"\n\nIf participants agree, these assessments may be videotaped for training and education of the research team.","confidence":0.99951171875,"confidence_rate":0.9999956392907748},{"cnt":[[120,988],[883,988],[883,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":764,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"837acf43b36c481ab73667213c910604","type":"text","conversion_output":true,"text":"The videotapes will include the patients face.","text_display":" The videotapes will include the patients face.","confidence":1,"confidence_rate":1},{"cnt":[[120,1074],[1098,1074],[1098,1124],[120,1124]],"region":{"top_left_x":120,"top_left_y":1074,"width":978,"height":50},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d044b9ce8ab046de9a607568c6148927","type":"text","conversion_output":true,"text":"ii) Health-related Quality of Life (Aims 2 and 3 in Figure 2)","text_display":"\nii) Health-related Quality of Life (Aims 2 and 3 in Figure 2)","confidence":1,"confidence_rate":1},{"cnt":[[120,1119],[1979,1119],[1979,1167],[120,1167]],"region":{"top_left_x":120,"top_left_y":1119,"width":1859,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9fff8891d88c4a50a4e865c9a89abfad","type":"text","conversion_output":true,"text":"As part of the ongoing SATISFY-SOS study, patient self-reported Health-related Quality of Life information will","text_display":"\n\nAs part of the ongoing SATISFY-SOS study, patient self-reported Health-related Quality of Life information will","confidence":1,"confidence_rate":1},{"cnt":[[120,1162],[1882,1162],[1882,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1162,"width":1763,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec27b4adbe7949d882208946ae0afef1","type":"text","conversion_output":true,"text":"be assessed through the Veteran's RAND 12-item Health Survey at baseline (preoperatively) and during","text_display":" be assessed through the Veteran's RAND 12-item Health Survey at baseline (preoperatively) and during","confidence":1,"confidence_rate":1},{"cnt":[[120,1207],[1951,1207],[1951,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1831,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10aef2f466094b44a48590e389316d5b","type":"text","conversion_output":true,"text":"follow-up ( 30 -day and 1 -year). The VR-12 was derived from the Veterans RAND 36 Item Health Survey (VR-","text_display":" follow-up ( 30 -day and 1 -year). The VR-12 was derived from the Veterans RAND 36 Item Health Survey (VR","confidence":0.7120544910430908,"confidence_rate":0.9971502796279743},{"cnt":[[120,1250],[1921,1250],[1921,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1801,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c44cfdcd917447089ce8c0365ea5791b","type":"text","conversion_output":true,"text":"36 ) and contains 12 items relating to quality of life, including physical and mental health, as well as specific","text_display":"36 ) and contains 12 items relating to quality of life, including physical and mental health, as well as specific","confidence":0.9960975646972656,"confidence_rate":0.9999674166169199},{"cnt":[[120,1293],[1970,1293],[1970,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1851,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfbdf43837dc4b8a86cad3ec6f0a7156","type":"text","conversion_output":true,"text":"questions about functional status. Physical and Mental Health Summary Scores will be calculated. The VR-12","text_display":" questions about functional status. Physical and Mental Health Summary Scores will be calculated. The VR-12","confidence":1,"confidence_rate":1},{"cnt":[[120,1336],[1893,1336],[1893,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1336,"width":1773,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f72f32d5ea4b434dba71c84f6e52646c","type":"text","conversion_output":true,"text":"has been validated and is widely applied as a metric for tracking health-related quality of life in the United","text_display":" has been validated and is widely applied as a metric for tracking health-related quality of life in the United","confidence":1,"confidence_rate":1},{"cnt":[[120,1379],[277,1379],[277,1420],[120,1420]],"region":{"top_left_x":120,"top_left_y":1379,"width":158,"height":42},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09372a8daa6341a3a8eacee977dd30fb","type":"text","conversion_output":true,"text":"States. \\({ }^{97}\\)","text_display":" States. \\({ }^{97}\\)","confidence":1,"confidence_rate":1},{"cnt":[[120,1470],[707,1470],[707,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":587,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"580c399a860a4c8d81ca75a94eb98406","type":"text","conversion_output":true,"text":"iii) Falls (Aims 2 and 3 in Figure 2)","text_display":"\niii) Falls (Aims 2 and 3 in Figure 2)","confidence":1,"confidence_rate":1},{"cnt":[[120,1512],[1944,1512],[1944,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":1825,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bfaf120e9aa54230912c3ea7a88fd50f","type":"text","conversion_output":true,"text":"In the baseline (preoperative) questionnaire for the SATISFY-SOS study, patients are asked to indicate how","text_display":" In the baseline (preoperative) questionnaire for the SATISFY-SOS study, patients are asked to indicate how","confidence":1,"confidence_rate":1},{"cnt":[[120,1555],[1970,1555],[1970,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1851,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4043528e8c9d4497ade1652dd2353f6d","type":"text","conversion_output":true,"text":"many times they fell during the past 6 months and injuries from falls are ascertained. Patients who fell at least","text_display":" many times they fell during the past 6 months and injuries from falls are ascertained. Patients who fell at least","confidence":1,"confidence_rate":1},{"cnt":[[120,1598],[1996,1598],[1996,1646],[120,1646]],"region":{"top_left_x":120,"top_left_y":1598,"width":1876,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e2eae2c2666b487abed5a02f7974a71d","type":"text","conversion_output":true,"text":"one time during the past six months will be classified as having a previous history of falls. On the 30 -day and 1 -","text_display":" one time during the past six months will be classified as having a previous history of falls. On the 30 -day and 1 ","confidence":0.9882867336273193,"confidence_rate":0.9999072294442662},{"cnt":[[120,1644],[1949,1644],[1949,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1643,"width":1829,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5845c120f5734bc9ad6d2911d10f7a59","type":"text","conversion_output":true,"text":"year follow-up postoperative questionnaires, patients are asked to indicate whether they have experienced a","text_display":"year follow-up postoperative questionnaires, patients are asked to indicate whether they have experienced a","confidence":1,"confidence_rate":1},{"cnt":[[120,1732],[120,1686],[1970,1688],[1970,1734]],"region":{"top_left_x":120,"top_left_y":1686,"width":1851,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fab2ab595d9492b89539c18b16b7184","type":"text","conversion_output":true,"text":"fall. Based on this information, we will define two outcomes measures: Falls within 30-days and falls within 1-","text_display":" fall. Based on this information, we will define two outcomes measures: Falls within 30-days and falls within 1","confidence":0.7146334648132324,"confidence_rate":0.9971077638354072},{"cnt":[[120,1732],[1884,1732],[1884,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1731,"width":1765,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bb09fda2708343babdb31541986f67f0","type":"text","conversion_output":true,"text":"year of surgery. Data on number of falls and injurious falls will also be collected. The wording for the falls","text_display":"year of surgery. Data on number of falls and injurious falls will also be collected. The wording for the falls","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1880,1775],[1880,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1760,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd50ad58ede0452a80e8b793e92e1c17","type":"text","conversion_output":true,"text":"questions used in SATISFY-SOS is based on the definition proposed by the Prevention of Falls Network","text_display":" questions used in SATISFY-SOS is based on the definition proposed by the Prevention of Falls Network","confidence":1,"confidence_rate":1},{"cnt":[[120,1815],[1656,1815],[1656,1865],[120,1865]],"region":{"top_left_x":120,"top_left_y":1815,"width":1537,"height":50},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e723ceab613f49948835d4367566dea1","type":"text","conversion_output":true,"text":"Europe (ProFaNE); the calculation for severity of fall is based on a standard algorithm. \\({ }^{98-100}\\)","text_display":" Europe (ProFaNE); the calculation for severity of fall is based on a standard algorithm. \\({ }^{98-100}\\)","confidence":0.9737205505371094,"confidence_rate":0.9997487964096863},{"cnt":[[116,1901],[969,1899],[969,1953],[116,1955]],"region":{"top_left_x":115,"top_left_y":1899,"width":855,"height":57},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2306350a575b426a8b2135172f8cd586","type":"section_header","conversion_output":false,"children_ids":["c653fd7870a74a199529acc18ca2dc73"],"text":"","text_display":""},{"cnt":[[120,1904],[965,1904],[965,1949],[120,1949]],"region":{"top_left_x":120,"top_left_y":1903,"width":845,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c653fd7870a74a199529acc18ca2dc73","type":"text","conversion_output":true,"parent_id":"2306350a575b426a8b2135172f8cd586","text":"Pre-specified additional analyses and sub-studies","text_display":"\n\n\\section*{Pre-specified additional analyses and sub-studies}","confidence":1,"confidence_rate":1},{"cnt":[[120,1949],[1888,1949],[1888,1996],[120,1996]],"region":{"top_left_x":120,"top_left_y":1948,"width":1769,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daa3a92c03884781ae3a66ad27e0849e","type":"text","conversion_output":true,"text":"The primary aim of the ENGAGES study is to determine whether an EEG-guided anesthetic protocol can","text_display":"\n\nThe primary aim of the ENGAGES study is to determine whether an EEG-guided anesthetic protocol can","confidence":1,"confidence_rate":1},{"cnt":[[120,1994],[1970,1994],[1970,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":1851,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7798c4fa8b44723b8efcbdfffd44ecc","type":"text","conversion_output":true,"text":"decrease postoperative delirium and its associated downstream negative sequelae (e.g., decrement in quality","text_display":" decrease postoperative delirium and its associated downstream negative sequelae (e.g., decrement in quality","confidence":1,"confidence_rate":1},{"cnt":[[120,2037],[1957,2037],[1957,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1838,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"538f5f4519214112b3ee8363a7b33105","type":"text","conversion_output":true,"text":"of life, falls). However, it is important that large, randomized trials collect and report data on multiple clinically","text_display":" of life, falls). However, it is important that large, randomized trials collect and report data on multiple clinically","confidence":1,"confidence_rate":1},{"cnt":[[120,2080],[1914,2080],[1914,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1795,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9e77ce907ebf47299bc52eedf133be22","type":"text","conversion_output":true,"text":"relevant outcomes to maximize scientific yield and efficiency. The ENGAGES trial will have the potential to","text_display":" relevant outcomes to maximize scientific yield and efficiency. The ENGAGES trial will have the potential to","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-20","page":20,"lines":[{"cnt":[[116,198],[593,198],[593,251],[116,251]],"region":{"top_left_x":116,"top_left_y":197,"width":477,"height":55},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9edb331f7ea2434ab577e4b450553437","type":"section_header","conversion_output":false,"children_ids":["cb0b57fb342140bc97dd1ed5bcb02557"],"text":"","text_display":""},{"cnt":[[120,202],[589,202],[589,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":469,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cb0b57fb342140bc97dd1ed5bcb02557","type":"text","conversion_output":true,"parent_id":"9edb331f7ea2434ab577e4b450553437","text":"Patient Centered Approach","text_display":"\n\n\\section*{Patient Centered Approach}","confidence":0.99951171875,"confidence_rate":0.9999837201159151},{"cnt":[[120,245],[1974,245],[1974,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1855,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"80a695cbd66448ce9b3762d2106ee505","type":"text","conversion_output":true,"text":"Several aspects of the ENGAGES study are patient centered in their conception. There is a community liaison","text_display":"\n\nSeveral aspects of the ENGAGES study are patient centered in their conception. There is a community liaison","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1970,288],[1970,335],[120,335]],"region":{"top_left_x":120,"top_left_y":287,"width":1851,"height":49},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c73164189df842f992e65d53f31f0c15","type":"text","conversion_output":true,"text":"group that has been actively involved in the design and in the conduct of the study. Important outcomes in the","text_display":" group that has been actively involved in the design and in the conduct of the study. Important outcomes in the","confidence":1,"confidence_rate":1},{"cnt":[[120,333],[1923,333],[1923,380],[120,380]],"region":{"top_left_x":120,"top_left_y":333,"width":1803,"height":48},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"28bccf40827343a5b005dd5c3100ec78","type":"text","conversion_output":true,"text":"study are based on patient reported outcomes measures. Both patients and their families are provided with","text_display":" study are based on patient reported outcomes measures. Both patients and their families are provided with","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1833,378],[1833,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1713,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"969f8aa466034f4eaf0a00c9be9bfb9d","type":"text","conversion_output":true,"text":"educational material on delirium, its risk factors and its sequelae. The study also includes patient self-","text_display":" educational material on delirium, its risk factors and its sequelae. The study also includes patient self","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1919,421],[1919,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1799,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6b17a99ec3ea440d940add675ab83dcb","type":"text","conversion_output":true,"text":"assessment for delirium and implementation of the validated Family Confusion Assessment Method (FAM-","text_display":"assessment for delirium and implementation of the validated Family Confusion Assessment Method (FAM","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1880,464],[1880,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1760,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"60da5e9cf76942f6849b8fcb85f40c32","type":"text","conversion_output":true,"text":"CAM) \\({ }^{103,104}\\) instrument both in hospital and after hospital discharge. Both of these will be included in pre-","text_display":"CAM) \\({ }^{103,104}\\) instrument both in hospital and after hospital discharge. Both of these will be included in pre","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1158,507],[1158,556],[120,556]],"region":{"top_left_x":120,"top_left_y":507,"width":1039,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"009fc8d566e64606ae8e34c1e194e48f","type":"text","conversion_output":true,"text":"specified sub-studies of the ENGAGES trial (see addendum).","text_display":"specified sub-studies of the ENGAGES trial (see addendum).","confidence":1,"confidence_rate":1},{"cnt":[[116,591],[462,591],[462,645],[116,645]],"region":{"top_left_x":116,"top_left_y":590,"width":346,"height":55},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ac2207bbdf74550be5aa6c65dfe32d7","type":"section_header","conversion_output":false,"children_ids":["10cacdf87b8f45d3923b340bc7accbd2"],"text":"","text_display":""},{"cnt":[[120,597],[458,597],[458,640],[120,640]],"region":{"top_left_x":120,"top_left_y":597,"width":338,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"10cacdf87b8f45d3923b340bc7accbd2","type":"text","conversion_output":true,"parent_id":"9ac2207bbdf74550be5aa6c65dfe32d7","text":"Statistical Analyses","text_display":"\n\n\\section*{Statistical Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[1966,640],[1966,685],[120,685]],"region":{"top_left_x":120,"top_left_y":640,"width":1846,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4ae88c4d75240ce8cd3b2564f38ddaf","type":"text","conversion_output":true,"text":"i) Effectiveness of EEG-guided anesthesia protocol in reducing incident postoperative delirium compared with","text_display":"\ni) Effectiveness of EEG-guided anesthesia protocol in reducing incident postoperative delirium compared with","confidence":1,"confidence_rate":1},{"cnt":[[120,683],[814,683],[814,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":695,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a36b5c456a364004ad32d2047a52e570","type":"text","conversion_output":true,"text":"usual anesthetic care (Aim 1 in Figure 2)","text_display":" usual anesthetic care (Aim 1 in Figure 2)","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1863,726],[1863,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1743,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b2ec55efb0b74f859ef137fd3eff7b94","type":"text","conversion_output":true,"text":"We will follow the intention-to-treat principle for all analyses. The primary endpoint of our analysis is the","text_display":"\nWe will follow the intention-to-treat principle for all analyses. The primary endpoint of our analysis is the","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1979,769],[1979,816],[120,816]],"region":{"top_left_x":120,"top_left_y":769,"width":1859,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"657e373c5e5c47ed94f92fb1baa664cf","type":"text","conversion_output":true,"text":"incidence of postoperative delirium as defined previously. The incidence of delirium will be compared between","text_display":" incidence of postoperative delirium as defined previously. The incidence of delirium will be compared between","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,814],[1949,814],[1949,862],[120,862]],"region":{"top_left_x":120,"top_left_y":814,"width":1829,"height":48},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2099b13d07b94e64a4baf3b914f6acb3","type":"text","conversion_output":true,"text":"groups using a chi-square test, and the difference in delirium incidence with \\(95 \\%\\) confidence intervals will be","text_display":" groups using a chi-square test, and the difference in delirium incidence with \\(95 \\%\\) confidence intervals will be","confidence":1,"confidence_rate":1},{"cnt":[[120,859],[1962,859],[1962,904],[120,904]],"region":{"top_left_x":120,"top_left_y":859,"width":1842,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e15c17bfcfe64495bca159e52c6a0f22","type":"text","conversion_output":true,"text":"calculated. Prespecified exploratory subgroup analyses: we will test for effect modification by known baseline","text_display":" calculated. Prespecified exploratory subgroup analyses: we will test for effect modification by known baseline","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1897,902],[1897,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1778,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"763191c044234fd9b30f10ed36f6f11b","type":"text","conversion_output":true,"text":"delirium risk factors (i.e., age \\([<70\\) and \\(\\geq 70]\\), sex, history of falls, and type of surgery [cardiac versus non-","text_display":" delirium risk factors (i.e., age \\([<70\\) and \\(\\geq 70]\\), sex, history of falls, and type of surgery [cardiac versus non","confidence":0.8875346183776855,"confidence_rate":0.9990304885584916},{"cnt":[[120,945],[286,945],[286,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":166,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c24ac9b75f2a4022a818866d64fa4007","type":"text","conversion_output":true,"text":"cardiac]).","text_display":"cardiac]).","confidence":1,"confidence_rate":1},{"cnt":[[120,1031],[1949,1031],[1949,1079],[120,1079]],"region":{"top_left_x":120,"top_left_y":1031,"width":1829,"height":48},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1146aa4c1b2f422b8f5ec83e108669f9","type":"text","conversion_output":true,"text":"ii) Effectiveness of EEG-guided anesthesia protocol in improving patient reported outcomes of health-related","text_display":"\nii) Effectiveness of EEG-guided anesthesia protocol in improving patient reported outcomes of health-related","confidence":1,"confidence_rate":1},{"cnt":[[120,1076],[1242,1076],[1242,1124],[120,1124]],"region":{"top_left_x":120,"top_left_y":1076,"width":1122,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"953cb7fb4e5e4a00b88241fce3a89737","type":"text","conversion_output":true,"text":"quality of life and preventing postoperative falls (Aim 2 in Figure 2)","text_display":" quality of life and preventing postoperative falls (Aim 2 in Figure 2)","confidence":0.99951171875,"confidence_rate":0.9999937384747559},{"cnt":[[120,1164],[591,1164],[591,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1164,"width":471,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4f4b3166a964b53bf8b16ef10736860","type":"text","conversion_output":true,"text":"Health-related quality of life","text_display":"\n\nHealth-related quality of life","confidence":1,"confidence_rate":1},{"cnt":[[120,1207],[1824,1207],[1824,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1705,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a36c072c9c2481a81d5aa22c17bd8a3","type":"text","conversion_output":true,"text":"Random effects regression models based on PROC MIXED in SAS will be used to compare Physical","text_display":"\nRandom effects regression models based on PROC MIXED in SAS will be used to compare Physical","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[120,1250],[1955,1250],[1955,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1836,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bd52148e7a424fac810fec7884fb0be8","type":"text","conversion_output":true,"text":"Summary Score change over 12 months between the intervention and usual care group by introducing terms","text_display":" Summary Score change over 12 months between the intervention and usual care group by introducing terms","confidence":1,"confidence_rate":1},{"cnt":[[120,1296],[1931,1296],[1931,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1295,"width":1812,"height":44},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a2cf8bbc55940159e9c94bdccd12ed6","type":"text","conversion_output":true,"text":"for time, indicator variables for treatment group and time x treatment group interactions with the latter set of","text_display":" for time, indicator variables for treatment group and time x treatment group interactions with the latter set of","confidence":0.78271484375,"confidence_rate":0.9979082861286007},{"cnt":[[120,1338],[1931,1338],[1931,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1338,"width":1812,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79070299391c448eb2623ac0950adadb","type":"text","conversion_output":true,"text":"regression coefficients of primary interest. The model will be controlled for baseline health-related quality of","text_display":" regression coefficients of primary interest. The model will be controlled for baseline health-related quality of","confidence":1,"confidence_rate":1},{"cnt":[[120,1384],[1884,1384],[1884,1429],[120,1429]],"region":{"top_left_x":120,"top_left_y":1383,"width":1765,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44625b1affb64237a5b86a499fa350c2","type":"text","conversion_output":true,"text":"life. Potential confounding factors including age, gender and relevant comorbidities will be evaluated and","text_display":" life. Potential confounding factors including age, gender and relevant comorbidities will be evaluated and","confidence":1,"confidence_rate":1},{"cnt":[[120,1427],[1861,1427],[1861,1472],[120,1472]],"region":{"top_left_x":120,"top_left_y":1426,"width":1741,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e8131d3ea1447e2a9548420d56b3a6e","type":"text","conversion_output":true,"text":"controlled for in the model. We will utilize the same analysis approach to evaluate the Mental Summary","text_display":" controlled for in the model. We will utilize the same analysis approach to evaluate the Mental Summary","confidence":1,"confidence_rate":1},{"cnt":[[120,1470],[256,1470],[256,1510],[120,1510]],"region":{"top_left_x":120,"top_left_y":1469,"width":136,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ffa43e8b58f64cd2bd4c176cba86ce4f","type":"text","conversion_output":true,"text":"Scores.","text_display":" Scores.","confidence":1,"confidence_rate":1},{"cnt":[[120,1512],[1755,1512],[1755,1560],[120,1560]],"region":{"top_left_x":120,"top_left_y":1512,"width":1636,"height":48},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"daec72d87cf34e89a3e578f19fe7f63c","type":"text","conversion_output":true,"text":"The analysis is primarily based on the following model: \\(Y _{ it }=\\alpha+\\beta_{1} t +\\beta_{2 A} X _{ i 1}+\\beta_{3 A} X _{ i 1} t +\\beta_{4} t Y _{ i 0}+ e _{ it }\\)","text_display":"\nThe analysis is primarily based on the following model: \\(Y _{ it }=\\alpha+\\beta_{1} t +\\beta_{2 A} X _{ i 1}+\\beta_{3 A} X _{ i 1} t +\\beta_{4} t Y _{ i 0}+ e _{ it }\\)","confidence":0.5513209390357796,"confidence_rate":0.9970711046375815},{"cnt":[[1865,1512],[1921,1512],[1921,1560],[1865,1560]],"region":{"top_left_x":1864,"top_left_y":1512,"width":57,"height":48},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06d8e54c72b1469a98fa397545b8c6be","type":"equation_number","conversion_output":false,"text":"(1)","text_display":"","confidence":1,"confidence_rate":1},{"cnt":[[116,1555],[1989,1555],[1989,1603],[116,1603]],"region":{"top_left_x":116,"top_left_y":1555,"width":1874,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"688716f275194ca7bdfbf94270fcb99e","type":"text","conversion_output":true,"text":"where \\(Y _{ it }=\\) QOL for subject i at time t , where \\(t =0\\) for baseline, \\(t =1\\) for 12 months. \\(X _{ i 1}=1\\) if ith subject is in the","text_display":" where \\(Y _{ it }=\\) QOL for subject i at time t , where \\(t =0\\) for baseline, \\(t =1\\) for 12 months. \\(X _{ i 1}=1\\) if ith subject is in the","confidence":0.5498762737317975,"confidence_rate":0.9966457393631962},{"cnt":[[120,1598],[1962,1598],[1962,1646],[120,1646]],"region":{"top_left_x":120,"top_left_y":1598,"width":1842,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"00bb2c78e940499cb21f58b49ab31ee1","type":"text","conversion_output":true,"text":"Intervention group, \\(=0\\) otherwise \\(e _{ it } \\sim N \\left(0, \\sigma^{2}\\right) \\beta_{3 A}\\) is the mean difference in Physical Summary Score change","text_display":" Intervention group, \\(=0\\) otherwise \\(e _{ it } \\sim N \\left(0, \\sigma^{2}\\right) \\beta_{3 A}\\) is the mean difference in Physical Summary Score change","confidence":0.6025771928705126,"confidence_rate":0.9965600831724595},{"cnt":[[120,1644],[1929,1644],[1929,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1643,"width":1810,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3a211a0c7e53434aaed3c83c8e71fd44","type":"text","conversion_output":true,"text":"between the Intervention and usual care groups. The coefficient \\(\\beta_{2 A}\\) allows for mean differences in Physical","text_display":" between the Intervention and usual care groups. The coefficient \\(\\beta_{2 A}\\) allows for mean differences in Physical","confidence":0.8515625,"confidence_rate":0.9987153667950626},{"cnt":[[120,1689],[1904,1689],[1904,1734],[120,1734]],"region":{"top_left_x":120,"top_left_y":1688,"width":1784,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b38a6c2eb2dc4fc088efed869ae20523","type":"text","conversion_output":true,"text":"Summary Scores between groups at baseline. The coefficient \\(\\beta_{4}\\) allows the change in Physical Summary","text_display":" Summary Scores between groups at baseline. The coefficient \\(\\beta_{4}\\) allows the change in Physical Summary","confidence":0.99951171875,"confidence_rate":0.9999957157942815},{"cnt":[[120,1732],[655,1732],[655,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1731,"width":536,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a273af770fc414c80eb3c732def3911","type":"text","conversion_output":true,"text":"Score to depend on initial level.","text_display":" Score to depend on initial level.","confidence":1,"confidence_rate":1},{"cnt":[[116,1818],[443,1818],[443,1867],[116,1867]],"region":{"top_left_x":116,"top_left_y":1817,"width":327,"height":50},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c0908611162743d2bcdb6e0e0951ce4a","type":"section_header","conversion_output":false,"children_ids":["a2fe0bf68d514d9b937545caeccf5e86"],"text":"","text_display":""},{"cnt":[[120,1818],[438,1818],[438,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":319,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2fe0bf68d514d9b937545caeccf5e86","type":"text","conversion_output":true,"parent_id":"c0908611162743d2bcdb6e0e0951ce4a","text":"Postoperative falls","text_display":"\n\n\\section*{Postoperative falls}","confidence":1,"confidence_rate":1},{"cnt":[[120,1863],[1987,1863],[1987,1910],[120,1910]],"region":{"top_left_x":120,"top_left_y":1862,"width":1868,"height":48},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54bb20ba5045473880ad5a31dea7baaf","type":"text","conversion_output":true,"text":"Chi square test will be used to compare the incidence of falls at 12 -months postoperatively between patients in","text_display":"\n\nChi square test will be used to compare the incidence of falls at 12 -months postoperatively between patients in","confidence":0.616014364986131,"confidence_rate":0.9959707642747532},{"cnt":[[120,1908],[900,1908],[900,1953],[120,1953]],"region":{"top_left_x":120,"top_left_y":1907,"width":781,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f284f390e5e64ab9abe61f206b98db75","type":"text","conversion_output":true,"text":"the EEG-guided and in the usual care groups.","text_display":" the EEG-guided and in the usual care groups.","confidence":1,"confidence_rate":1},{"cnt":[[120,1994],[1974,1994],[1974,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":1855,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d7f91f38b0ee4bbba47803ef2c3b2110","type":"text","conversion_output":true,"text":"iii) Explore whether a multi-component safety intervention is associated with improved patient reported health-","text_display":"\niii) Explore whether a multi-component safety intervention is associated with improved patient reported health","confidence":1,"confidence_rate":1},{"cnt":[[120,2037],[1583,2037],[1583,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1464,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"542b20b8006a461294109c7c5a3f233e","type":"text","conversion_output":true,"text":"related quality of life and decreased incidence of postoperative falls (Aim 3 in Figure 2)","text_display":"related quality of life and decreased incidence of postoperative falls (Aim 3 in Figure 2)","confidence":1,"confidence_rate":1},{"cnt":[[120,2082],[1824,2082],[1824,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2081,"width":1705,"height":44},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62e45e9190ce44b5b72314e236a9e8d5","type":"text","conversion_output":true,"text":"We will design a prospective matched cohort study using the ENGAGES participants (received multi-","text_display":"\nWe will design a prospective matched cohort study using the ENGAGES participants (received multi-","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-21","page":21,"lines":[{"cnt":[[116,157],[1964,157],[1964,204],[116,204]],"region":{"top_left_x":116,"top_left_y":156,"width":1848,"height":49},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3ff2b0642b4d43cfb98d2639b7a9a839","type":"text","conversion_output":true,"text":"All statistical analyses will be performed using SAS, version 9.4 (SAS Institute, Inc., Cary, North Carolina). All","text_display":"\n\nAll statistical analyses will be performed using SAS, version 9.4 (SAS Institute, Inc., Cary, North Carolina). All","confidence":1,"confidence_rate":1},{"cnt":[[116,200],[1981,200],[1981,247],[116,247]],"region":{"top_left_x":116,"top_left_y":199,"width":1865,"height":49},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0326fb3034d404b9420ff899cd70e1f","type":"text","conversion_output":true,"text":"tests will be two-sided and by arbitrary convention \\({ }^{105}\\) will be considered statistically significant at a \\(p <0.05\\), and","text_display":" tests will be two-sided and by arbitrary convention \\({ }^{105}\\) will be considered statistically significant at a \\(p <0.05\\), and","confidence":0.85546875,"confidence_rate":0.9988775677034766},{"cnt":[[116,245],[1923,245],[1923,290],[116,290]],"region":{"top_left_x":116,"top_left_y":244,"width":1807,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ceb591be016645bfa0e9d211904aec02","type":"text","conversion_output":true,"text":"all results will be presented with estimates and \\(95 \\%\\) confidence intervals. However, based on the uncertain","text_display":" all results will be presented with estimates and \\(95 \\%\\) confidence intervals. However, based on the uncertain","confidence":1,"confidence_rate":1},{"cnt":[[116,288],[1886,288],[1886,335],[116,335]],"region":{"top_left_x":116,"top_left_y":287,"width":1771,"height":49},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1c712e08903c4329b36ad34546c9af60","type":"text","conversion_output":true,"text":"prior probability (plausibility) of the alternative hypothesis \\({ }^{106}\\) (i.e., EEG guidance of anesthesia decreases","text_display":" prior probability (plausibility) of the alternative hypothesis \\({ }^{106}\\) (i.e., EEG guidance of anesthesia decreases","confidence":1,"confidence_rate":1},{"cnt":[[116,331],[1843,331],[1843,380],[116,380]],"region":{"top_left_x":116,"top_left_y":330,"width":1728,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"30b4cd1eeec14431a1d781925b23fe6f","type":"text","conversion_output":true,"text":"postoperative delirium) and concerns raised about lack of reproducibility in science \\({ }^{107,108}\\), a statistically","text_display":" postoperative delirium) and concerns raised about lack of reproducibility in science \\({ }^{107,108}\\), a statistically","confidence":1,"confidence_rate":1},{"cnt":[[116,378],[1940,378],[1940,423],[116,423]],"region":{"top_left_x":116,"top_left_y":378,"width":1825,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1103813930c843fa80ac49f87f6ac64a","type":"text","conversion_output":true,"text":"significant result with a p value just <0.05 should be considered as preliminary, and future studies should be","text_display":" significant result with a p value just <0.05 should be considered as preliminary, and future studies should be","confidence":0.9975605006329715,"confidence_rate":0.9999787612708166},{"cnt":[[116,421],[1880,421],[1880,466],[116,466]],"region":{"top_left_x":116,"top_left_y":421,"width":1764,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8edd9998035b4150b331c82d2ceaaee5","type":"text","conversion_output":true,"text":"conducted for corroboration. A more stringent p value (e.g., p<0.005) would be required to conclude that","text_display":" conducted for corroboration. A more stringent p value (e.g., p<0.005) would be required to conclude that","confidence":0.5063139349222183,"confidence_rate":0.9937754315836095},{"cnt":[[116,464],[1837,464],[1837,509],[116,509]],"region":{"top_left_x":116,"top_left_y":464,"width":1721,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"135128df8f3a4f029300cee0741687ff","type":"text","conversion_output":true,"text":"subsequent studies would be very likely to reproduce these results with a p value <0.05. \\({ }^{109}\\) Apart from","text_display":" subsequent studies would be very likely to reproduce these results with a p value <0.05. \\({ }^{109}\\) Apart from","confidence":0.844447910785675,"confidence_rate":0.9985682105224242},{"cnt":[[116,507],[1972,507],[1972,554],[116,554]],"region":{"top_left_x":116,"top_left_y":507,"width":1857,"height":48},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"176d2d130f754458a88a0ffb937c1c35","type":"text","conversion_output":true,"text":"statistical significance, the ultimate decision regarding the routine implementation of EEG-guidance of general","text_display":" statistical significance, the ultimate decision regarding the routine implementation of EEG-guidance of general","confidence":1,"confidence_rate":1},{"cnt":[[116,552],[1790,552],[1790,597],[116,597]],"region":{"top_left_x":116,"top_left_y":552,"width":1674,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0a97ab8f9c3b49529ea43c164345363f","type":"text","conversion_output":true,"text":"anesthesia in preventing postoperative delirium will also depend on the estimated effect size of this","text_display":" anesthesia in preventing postoperative delirium will also depend on the estimated effect size of this","confidence":0.998046875,"confidence_rate":0.9999815564452184},{"cnt":[[116,595],[335,595],[335,638],[116,638]],"region":{"top_left_x":116,"top_left_y":595,"width":220,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"79118cc67cda40c1b7d5bc6fd4d25a27","type":"text","conversion_output":true,"text":"intervention.","text_display":" intervention.","confidence":0.99951171875,"confidence_rate":0.9999728670071003},{"cnt":[[114,679],[563,679],[563,733],[114,733]],"region":{"top_left_x":113,"top_left_y":678,"width":450,"height":55},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d69373abda094045af76d8638ad1745e","type":"section_header","conversion_output":false,"children_ids":["db1f746322ef4f13add05b565b39d602"],"text":"","text_display":""},{"cnt":[[116,683],[561,683],[561,728],[116,728]],"region":{"top_left_x":116,"top_left_y":683,"width":445,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"db1f746322ef4f13add05b565b39d602","type":"text","conversion_output":true,"parent_id":"d69373abda094045af76d8638ad1745e","text":"Sample Size Calculations","text_display":"\n\n\\section*{Sample Size Calculations}","confidence":1,"confidence_rate":1},{"cnt":[[116,726],[1435,726],[1435,771],[116,771]],"region":{"top_left_x":116,"top_left_y":726,"width":1320,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"14f97d93c0b04deebcc56b8e779c3bfb","type":"text","conversion_output":true,"text":"All sample size calculations have been performed using SAS PROC POWER.","text_display":"\n\nAll sample size calculations have been performed using SAS PROC POWER.","confidence":1,"confidence_rate":1},{"cnt":[[114,767],[518,767],[518,819],[114,819]],"region":{"top_left_x":113,"top_left_y":766,"width":405,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d8f70f632484319abc24603ba7a8a13","type":"section_header","conversion_output":false,"children_ids":["cc252fa79877434ea93024f5b2122019"],"text":"","text_display":""},{"cnt":[[116,769],[513,769],[513,814],[116,814]],"region":{"top_left_x":116,"top_left_y":769,"width":398,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc252fa79877434ea93024f5b2122019","type":"text","conversion_output":true,"parent_id":"1d8f70f632484319abc24603ba7a8a13","text":"i) Decrease in Delirium","text_display":"\n\n\\section*{i) Decrease in Delirium}","confidence":1,"confidence_rate":1},{"cnt":[[116,812],[1934,812],[1934,862],[116,862]],"region":{"top_left_x":116,"top_left_y":812,"width":1818,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b58c7f9613e4871bfca83751838a37b","type":"text","conversion_output":true,"text":"Our sample size calculations are based on the anticipated delirium incidence and effect size for our primary","text_display":"\n\nOur sample size calculations are based on the anticipated delirium incidence and effect size for our primary","confidence":1,"confidence_rate":1},{"cnt":[[116,855],[1936,855],[1936,904],[116,904]],"region":{"top_left_x":116,"top_left_y":855,"width":1820,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24b6ccb9129a448c9a3393792ce2f89c","type":"text","conversion_output":true,"text":"endpoint analysis. Based on results of a previously published meta-analysis of four studies investigating the","text_display":" endpoint analysis. Based on results of a previously published meta-analysis of four studies investigating the","confidence":1,"confidence_rate":1},{"cnt":[[116,902],[1974,902],[1974,947],[116,947]],"region":{"top_left_x":116,"top_left_y":902,"width":1859,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82278fbdfef14c0fa866cd0383e67864","type":"text","conversion_output":true,"text":"use of BIS-guided anesthetic administration, we conservatively assume an incidence of postoperative delirium","text_display":" use of BIS-guided anesthetic administration, we conservatively assume an incidence of postoperative delirium","confidence":1,"confidence_rate":1},{"cnt":[[116,945],[1974,945],[1974,990],[116,990]],"region":{"top_left_x":116,"top_left_y":945,"width":1859,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9f6c950537dd45ec875be1a47db061f2","type":"text","conversion_output":true,"text":"in the routine anesthesia care group of \\(25 \\% .^{29}\\) We performed a sample size sensitivity analysis and calculated","text_display":" in the routine anesthesia care group of \\(25 \\% .^{29}\\) We performed a sample size sensitivity analysis and calculated","confidence":0.96826171875,"confidence_rate":0.9997399301333904},{"cnt":[[116,988],[1931,988],[1931,1033],[116,1033]],"region":{"top_left_x":116,"top_left_y":988,"width":1816,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"da5073ef85d24aeeafe94c8dd5f8fc49","type":"text","conversion_output":true,"text":"different scenarios with different values for the delirium incidence in the intervention arm and corresponding","text_display":" different scenarios with different values for the delirium incidence in the intervention arm and corresponding","confidence":1,"confidence_rate":1},{"cnt":[[116,1031],[1970,1031],[1970,1079],[116,1079]],"region":{"top_left_x":116,"top_left_y":1031,"width":1855,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"98f46492bf1f4bf1b461a3a6f53d33fd","type":"text","conversion_output":true,"text":"power ( \\(80 \\%, 90 \\%\\), and \\(95 \\%\\) ). With a two sided alpha \\(<5 \\%\\) and 1,232 patients ( 616 per arm), the trial will have","text_display":" power ( \\(80 \\%, 90 \\%\\), and \\(95 \\%\\) ). With a two sided alpha \\(<5 \\%\\) and 1,232 patients ( 616 per arm), the trial will have","confidence":0.7584634676275709,"confidence_rate":0.9978756393063063},{"cnt":[[116,1076],[1944,1076],[1944,1121],[116,1121]],"region":{"top_left_x":116,"top_left_y":1076,"width":1829,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"585f33e089c94eea9f823ab6a750b8bd","type":"text","conversion_output":true,"text":"\\(>95 \\%\\) power to detect an absolute decrease in delirium incidence \\(\\geq 9 \\%,>90 \\%\\) power to detect a decrease in","text_display":" \\(>95 \\%\\) power to detect an absolute decrease in delirium incidence \\(\\geq 9 \\%,>90 \\%\\) power to detect a decrease in","confidence":0.9990236759185791,"confidence_rate":0.9999910385631244},{"cnt":[[116,1119],[1985,1119],[1985,1164],[116,1164]],"region":{"top_left_x":116,"top_left_y":1119,"width":1870,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7dff6701a60b4651b3cdaa81887669f4","type":"text","conversion_output":true,"text":"delirium incidence \\(\\geq 8 \\%\\), and \\(>80 \\%\\) power to detect a decrease in delirium incidence \\(\\geq 7 \\%\\). With a \\(7 \\%\\) decrease","text_display":" delirium incidence \\(\\geq 8 \\%\\), and \\(>80 \\%\\) power to detect a decrease in delirium incidence \\(\\geq 7 \\%\\). With a \\(7 \\%\\) decrease","confidence":1,"confidence_rate":1},{"cnt":[[116,1164],[1979,1164],[1979,1210],[116,1210]],"region":{"top_left_x":116,"top_left_y":1164,"width":1863,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1937ef923cb4e44929eed05ed0cf55b","type":"text","conversion_output":true,"text":"in delirium incidence, the \\(95 \\%\\) confidence interval would be approximately \\(3 \\%\\) to \\(12 \\%\\). Even a \\(3 \\%\\) decrease in","text_display":" in delirium incidence, the \\(95 \\%\\) confidence interval would be approximately \\(3 \\%\\) to \\(12 \\%\\). Even a \\(3 \\%\\) decrease in","confidence":0.99951171875,"confidence_rate":0.9999960612940623},{"cnt":[[116,1207],[1906,1207],[1906,1253],[116,1253]],"region":{"top_left_x":116,"top_left_y":1207,"width":1790,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"065e0543b269401e9b1699a7cbd1f6f6","type":"text","conversion_output":true,"text":"delirium incidence would be clinically important, suggesting that delirium would be prevented in one out of","text_display":" delirium incidence would be clinically important, suggesting that delirium would be prevented in one out of","confidence":1,"confidence_rate":1},{"cnt":[[116,1250],[1405,1250],[1405,1298],[116,1298]],"region":{"top_left_x":116,"top_left_y":1250,"width":1290,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f5e32ffda273412185140eb4c5d9c840","type":"text","conversion_output":true,"text":"every 33 at risk patients who received EEG-guidance of general anesthesia.","text_display":" every 33 at risk patients who received EEG-guidance of general anesthesia.","confidence":1,"confidence_rate":1},{"cnt":[[116,1336],[664,1336],[664,1386],[116,1386]],"region":{"top_left_x":116,"top_left_y":1336,"width":548,"height":50},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"88e4fe17d0ef413a9a40e58dba82e758","type":"section_header","conversion_output":true,"text":"ii) Health Related Quality of Life","text_display":"\n\n\\section*{ii) Health Related Quality of Life}","confidence":1,"confidence_rate":1},{"cnt":[[116,1381],[1901,1381],[1901,1429],[116,1429]],"region":{"top_left_x":116,"top_left_y":1381,"width":1786,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d865fa5ef5ca40d9bd0f25a94f54f826","type":"text","conversion_output":true,"text":"The overall sample size of our study is defined through estimations of the primary outcome (delirium). For","text_display":"\n\nThe overall sample size of our study is defined through estimations of the primary outcome (delirium). For","confidence":1,"confidence_rate":1},{"cnt":[[116,1427],[1989,1427],[1989,1472],[116,1472]],"region":{"top_left_x":116,"top_left_y":1426,"width":1874,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4c2c3d09d95410f9297021d31ca3fbf","type":"text","conversion_output":true,"text":"secondary analyses, we assume that \\(\\sim 80 \\%\\) of our trial population ( \\(\\sim 1,000\\) participants) will have completed the","text_display":" secondary analyses, we assume that \\(\\sim 80 \\%\\) of our trial population ( \\(\\sim 1,000\\) participants) will have completed the","confidence":0.9980475902557373,"confidence_rate":0.9999838487405106},{"cnt":[[116,1470],[1940,1470],[1940,1515],[116,1515]],"region":{"top_left_x":116,"top_left_y":1469,"width":1825,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56865add75874f8cbc8a2330387927d9","type":"text","conversion_output":true,"text":"trial and the 1 -year follow-up survey. With this sample size of 1,000 , we can detect a difference of 0.5 points","text_display":" trial and the 1 -year follow-up survey. With this sample size of 1,000 , we can detect a difference of 0.5 points","confidence":0.9341139793395996,"confidence_rate":0.9994634761485759},{"cnt":[[116,1512],[1953,1512],[1953,1560],[116,1560]],"region":{"top_left_x":116,"top_left_y":1512,"width":1837,"height":48},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6bf7e17b3d9d40c3ac0f9f12aadfb5c9","type":"text","conversion_output":true,"text":"(standard deviation of 2.5) in the mean change of Physical Health Score from baseline to 1 year between the","text_display":" (standard deviation of 2.5) in the mean change of Physical Health Score from baseline to 1 year between the","confidence":0.9824533313512802,"confidence_rate":0.9998460776188847},{"cnt":[[116,1558],[1721,1558],[1721,1605],[116,1605]],"region":{"top_left_x":116,"top_left_y":1557,"width":1605,"height":48},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"554e10fd9f7a4cdcb9d352ebfb46503b","type":"text","conversion_output":true,"text":"intervention and usual care group with a power of \\(>80 \\%\\) and a two-sided alpha level of \\(p <0.05\\).","text_display":" intervention and usual care group with a power of \\(>80 \\%\\) and a two-sided alpha level of \\(p <0.05\\).","confidence":0.9907436370849609,"confidence_rate":0.9999138975102384},{"cnt":[[116,1641],[501,1641],[501,1691],[116,1691]],"region":{"top_left_x":116,"top_left_y":1641,"width":385,"height":50},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"437320a22e4042f381872faba8b465e9","type":"section_header","conversion_output":true,"text":"iii) Postoperative Falls","text_display":"\n\n\\section*{iii) Postoperative Falls}","confidence":1,"confidence_rate":1},{"cnt":[[116,1689],[1983,1689],[1983,1734],[116,1734]],"region":{"top_left_x":116,"top_left_y":1688,"width":1868,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6c1217aca99a4e789ff513d3704fba01","type":"text","conversion_output":true,"text":"This calculation is similarly based on the assumption that \\(\\sim 80 \\%\\) of our trial population ( \\(\\sim 1,000\\) participants) will","text_display":"\n\nThis calculation is similarly based on the assumption that \\(\\sim 80 \\%\\) of our trial population ( \\(\\sim 1,000\\) participants) will","confidence":0.9833984375,"confidence_rate":0.9998671444381383},{"cnt":[[116,1732],[1916,1732],[1916,1777],[116,1777]],"region":{"top_left_x":116,"top_left_y":1731,"width":1801,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cee52062083e42fea76a7ee7384a2273","type":"text","conversion_output":true,"text":"have completed the trial and the 1 -year follow-up survey. Based on a study that showed a preoperative fall","text_display":" have completed the trial and the 1 -year follow-up survey. Based on a study that showed a preoperative fall","confidence":0.98583984375,"confidence_rate":0.9998759957948392},{"cnt":[[116,1775],[1983,1775],[1983,1824],[116,1824]],"region":{"top_left_x":116,"top_left_y":1774,"width":1868,"height":51},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e8c9d59bc72943338e8b997138724ec0","type":"text","conversion_output":true,"text":"prevalence of \\(33 \\%\\) over six months preoperatively in a similar patient population to the ENGAGES trail, we will","text_display":" prevalence of \\(33 \\%\\) over six months preoperatively in a similar patient population to the ENGAGES trail, we will","confidence":0.99951171875,"confidence_rate":0.9999958610212935},{"cnt":[[116,1818],[1919,1818],[1919,1865],[116,1865]],"region":{"top_left_x":116,"top_left_y":1817,"width":1803,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0b91fb8010464e72a77e9cc57110438e","type":"text","conversion_output":true,"text":"conservatively assume an incidence of postoperative falls at 1 -year in the routine anesthesia care group of","text_display":" conservatively assume an incidence of postoperative falls at 1 -year in the routine anesthesia care group of","confidence":0.96630859375,"confidence_rate":0.9997045950151573},{"cnt":[[116,1861],[1912,1861],[1912,1910],[116,1910]],"region":{"top_left_x":116,"top_left_y":1860,"width":1797,"height":50},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9de6f15c962b4ab18398f51f67393d0a","type":"text","conversion_output":true,"text":"\\(40 \\% .{ }^{110}\\) With a sample size of 1,000 , we will have \\(>80 \\%\\) power to detect an absolute risk reduction of \\(12 \\%\\)","text_display":" \\(40 \\% .{ }^{110}\\) With a sample size of 1,000 , we will have \\(>80 \\%\\) power to detect an absolute risk reduction of \\(12 \\%\\)","confidence":0.4799901247024536,"confidence_rate":0.9939523302385471},{"cnt":[[116,1906],[1605,1906],[1605,1953],[116,1953]],"region":{"top_left_x":116,"top_left_y":1905,"width":1489,"height":48},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"56f3426c58954b79be1c385d7c231037","type":"text","conversion_output":true,"text":"between the EEG-guided and the usual care group at a two-sided alpha level of \\(p <0.05\\).","text_display":" between the EEG-guided and the usual care group at a two-sided alpha level of \\(p <0.05\\).","confidence":0.9517064094543457,"confidence_rate":0.999489834455171},{"cnt":[[116,1989],[1079,1989],[1079,2039],[116,2039]],"region":{"top_left_x":116,"top_left_y":1989,"width":963,"height":50},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f72cd417076c4595a8742256ddfcf662","type":"section_header","conversion_output":true,"text":"Analysis of Pragmatic Elements of the ENGAGES Study","text_display":"\n\n\\section*{Analysis of Pragmatic Elements of the ENGAGES Study}","confidence":1,"confidence_rate":1},{"cnt":[[116,2037],[1899,2037],[1899,2084],[116,2084]],"region":{"top_left_x":116,"top_left_y":2036,"width":1784,"height":48},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"af08db157a884e68ab0c99d261da72a1","type":"text","conversion_output":true,"text":"According to seven of nine criteria elaborated in the pragmatic-explanatory continuum indicator summary","text_display":"\n\nAccording to seven of nine criteria elaborated in the pragmatic-explanatory continuum indicator summary","confidence":1,"confidence_rate":1},{"cnt":[[116,2080],[1798,2080],[1798,2125],[116,2125]],"region":{"top_left_x":116,"top_left_y":2079,"width":1683,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"221fa1dec49242aa994df9462ba87ffd","type":"text","conversion_output":true,"text":"(PRECIS-2) tool \\({ }^{111}\\), the ENGAGES trial is designed predominantly as a pragmatic rather than as an","text_display":" (PRECIS-2) tool \\({ }^{111}\\), the ENGAGES trial is designed predominantly as a pragmatic rather than as an","confidence":0.981051370035857,"confidence_rate":0.9998307182605897}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-22","page":22,"lines":[{"cnt":[[120,159],[1929,159],[1929,204],[120,204]],"region":{"top_left_x":120,"top_left_y":158,"width":1810,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"afa94259a8be40fc98703544f6b04672","type":"text","conversion_output":true,"text":"during the first phase of the study, there will be structured education of clinicians to increase their familiarity","text_display":"\nduring the first phase of the study, there will be structured education of clinicians to increase their familiarity","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1989,202],[1989,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1870,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5c0ee1d1b2a84da3bd426ec6f17073fd","type":"text","conversion_output":true,"text":"and comfort with EEG-guidance of anesthesia. We therefore anticipate that practitioner familiarity with EEG will","text_display":" and comfort with EEG-guidance of anesthesia. We therefore anticipate that practitioner familiarity with EEG will","confidence":1,"confidence_rate":1},{"cnt":[[120,245],[1962,245],[1962,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1842,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"58a59920089e42d095ed783bda5e99d7","type":"text","conversion_output":true,"text":"increase over the course of the study, although only basic knowledge regarding EEG analysis will be needed.","text_display":" increase over the course of the study, although only basic knowledge regarding EEG analysis will be needed.","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1863,288],[1863,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":1743,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"aae75c505b794f3ea62c84f52e8ba598","type":"text","conversion_output":true,"text":"Similarly, any anesthesia practitioner, regardless of their background or expertise, can apply the control","text_display":" Similarly, any anesthesia practitioner, regardless of their background or expertise, can apply the control","confidence":1,"confidence_rate":1},{"cnt":[[122,335],[1800,335],[1800,380],[122,380]],"region":{"top_left_x":122,"top_left_y":335,"width":1679,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e401852591404d81bc3e4f23a564c056","type":"text","conversion_output":true,"text":"(comparison) protocol. 5) Instructions on how to apply the EEG-guided protocol are flexible, offering","text_display":" (comparison) protocol. 5) Instructions on how to apply the EEG-guided protocol are flexible, offering","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1910,378],[1910,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1790,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be07e11514f34fea9ce190815a2d7129","type":"text","conversion_output":true,"text":"practitioners discretion in deciding how to formulate and apply it. Although clinicians carrying out the EEG-","text_display":" practitioners discretion in deciding how to formulate and apply it. Although clinicians carrying out the EEG","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1828,421],[1828,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1709,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7630128ed31f4ffc83e7c0c47327b0f1","type":"text","conversion_output":true,"text":"guided protocol will use their own discretion in managing anesthesia, there is an expectation that less","text_display":"guided protocol will use their own discretion in managing anesthesia, there is an expectation that less","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1953,464],[1953,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1833,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df75b50c726c49f98daa362610ef30c9","type":"text","conversion_output":true,"text":"anesthesia will be administered in the EEG-guided arm and that the cumulative duration of EEG suppression","text_display":" anesthesia will be administered in the EEG-guided arm and that the cumulative duration of EEG suppression","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1968,507],[1968,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1848,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4ec278b0353a42c3b5766039addf551a","type":"text","conversion_output":true,"text":"will be less in the EEG-guided arm. During the first phase of the study, clinician adherence to the EEG-guided","text_display":" will be less in the EEG-guided arm. During the first phase of the study, clinician adherence to the EEG-guided","confidence":1,"confidence_rate":1},{"cnt":[[120,552],[1962,552],[1962,595],[120,595]],"region":{"top_left_x":120,"top_left_y":552,"width":1842,"height":44},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4820285ddb8e4804b6780e5236732684","type":"text","conversion_output":true,"text":"protocol will be evaluated and will partially inform the value of proceeding with the second phase of the study.","text_display":" protocol will be evaluated and will partially inform the value of proceeding with the second phase of the study.","confidence":1,"confidence_rate":1},{"cnt":[[120,595],[1901,595],[1901,638],[120,638]],"region":{"top_left_x":120,"top_left_y":595,"width":1782,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9b1dd03fd4149d48a03de64fbde7a34","type":"text","conversion_output":true,"text":"Similar to the intervention arm, when patients are randomized to the control arm, anesthesia clinicians will","text_display":" Similar to the intervention arm, when patients are randomized to the control arm, anesthesia clinicians will","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[1938,640],[1938,683],[120,683]],"region":{"top_left_x":120,"top_left_y":640,"width":1818,"height":44},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b51bdccc48fd4dd68e13ca23f46b0a8f","type":"text","conversion_output":true,"text":"have leeway to pursue their usual practice with minimal restrictions. There are some limitations in relation to","text_display":" have leeway to pursue their usual practice with minimal restrictions. There are some limitations in relation to","confidence":1,"confidence_rate":1},{"cnt":[[120,683],[1897,683],[1897,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1778,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b1784f44914e4181b5f92d8309065fb3","type":"text","conversion_output":true,"text":"anesthetic technique (e.g. based on potent volatile anesthetic), however these are consistent with current","text_display":" anesthetic technique (e.g. based on potent volatile anesthetic), however these are consistent with current","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1968,726],[1968,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1848,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"323c0b8458a943198200c7dc8086242f","type":"text","conversion_output":true,"text":"practice at our institution and more broadly. 6) For the primary intervention of the ENGAGES trial, participants","text_display":" practice at our institution and more broadly. 6) For the primary intervention of the ENGAGES trial, participants","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1919,769],[1919,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1799,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a522711bc4a241b0a2c768d04596b86b","type":"text","conversion_output":true,"text":"will be anesthetized and will have no ability to impact adherence to the intervention. Therefore, this domain","text_display":" will be anesthetized and will have no ability to impact adherence to the intervention. Therefore, this domain","confidence":1,"confidence_rate":1},{"cnt":[[120,812],[1968,812],[1968,857],[120,857]],"region":{"top_left_x":120,"top_left_y":812,"width":1848,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e912f95eab04265ac4a0c018f95dcf1","type":"text","conversion_output":true,"text":"was left blank in the PRECIS-2 determination, as recommended \\({ }^{111}\\). 7) Patients enrolled to the ENGAGES trial","text_display":" was left blank in the PRECIS-2 determination, as recommended \\({ }^{111}\\). 7) Patients enrolled to the ENGAGES trial","confidence":0.9990236759185791,"confidence_rate":0.9999920585600194},{"cnt":[[120,855],[1863,855],[1863,900],[120,900]],"region":{"top_left_x":120,"top_left_y":855,"width":1743,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e41d81eb67854aa39c7a3978d5b3cf3f","type":"text","conversion_output":true,"text":"will be followed with more frequent visits and more extensive data collection than would occur in routine","text_display":" will be followed with more frequent visits and more extensive data collection than would occur in routine","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1809,902],[1809,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1689,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48d6781144f542399cd119e3cef8b7cd","type":"text","conversion_output":true,"text":"practice. 8) Incident delirium, the primary outcome of the study, is an objectively measured, clinically","text_display":" practice. 8) Incident delirium, the primary outcome of the study, is an objectively measured, clinically","confidence":0.99853515625,"confidence_rate":0.9999865513043565},{"cnt":[[120,945],[1884,945],[1884,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1765,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"be1446f12f8e448aa9d67572b81ecb05","type":"text","conversion_output":true,"text":"meaningful outcome to the study participants. The outcome can be assessed under usual conditions and","text_display":" meaningful outcome to the study participants. The outcome can be assessed under usual conditions and","confidence":1,"confidence_rate":1},{"cnt":[[120,988],[1910,988],[1910,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1790,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b92819de4fec49beb1afc4270de140fe","type":"text","conversion_output":true,"text":"typically does not rely on central adjudication. However, special training in rigorous delirium assessment is","text_display":" typically does not rely on central adjudication. However, special training in rigorous delirium assessment is","confidence":1,"confidence_rate":1},{"cnt":[[120,1033],[1974,1033],[1974,1076],[120,1076]],"region":{"top_left_x":120,"top_left_y":1033,"width":1855,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b9f7d58c0caa47f3b897e13741014893","type":"text","conversion_output":true,"text":"required. It is important to note that the abstraction of information of delirium from the medical records bolsters","text_display":" required. It is important to note that the abstraction of information of delirium from the medical records bolsters","confidence":0.99951171875,"confidence_rate":0.9999959300041316},{"cnt":[[120,1076],[1979,1076],[1979,1121],[120,1121]],"region":{"top_left_x":120,"top_left_y":1076,"width":1859,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab10a726720c4b208f393d64e069a474","type":"text","conversion_output":true,"text":"the pragmatic aspects of the trial, since this is an information source that is readily available at any hospital. 9)","text_display":" the pragmatic aspects of the trial, since this is an information source that is readily available at any hospital. 9)","confidence":1,"confidence_rate":1},{"cnt":[[120,1121],[1893,1121],[1893,1164],[120,1164]],"region":{"top_left_x":120,"top_left_y":1121,"width":1773,"height":44},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f1420c6764444211964212dc6abee644","type":"text","conversion_output":true,"text":"The analysis of the results will include all patients regardless of clinician compliance with the EEG-guided","text_display":" The analysis of the results will include all patients regardless of clinician compliance with the EEG-guided","confidence":1,"confidence_rate":1},{"cnt":[[120,1164],[1983,1164],[1983,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1164,"width":1864,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62824c7f4eae48a18b95b273c42c8314","type":"text","conversion_output":true,"text":"protocol (i.e. it will be an \"intention-to-treat\" analysis). The analysis will attempt to determine whether or not the","text_display":" protocol (i.e. it will be an \"intention-to-treat\" analysis). The analysis will attempt to determine whether or not the","confidence":0.99951171875,"confidence_rate":0.9999960292721264},{"cnt":[[120,1207],[1927,1207],[1927,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1808,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"515f2135af5f42fcb0203573aa9fb93d","type":"text","conversion_output":true,"text":"EEG-guided protocol prevents postoperative delirium under the usual conditions, with all the noise inherent","text_display":" EEG-guided protocol prevents postoperative delirium under the usual conditions, with all the noise inherent","confidence":1,"confidence_rate":1},{"cnt":[[120,1250],[1953,1250],[1953,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1833,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1575d8d9fc0749cd92a369d29aa0c1ea","type":"text","conversion_output":true,"text":"therein. Although in most respects the ENGAGES trial was judged to be pragmatic, this appraisal might have","text_display":" therein. Although in most respects the ENGAGES trial was judged to be pragmatic, this appraisal might have","confidence":1,"confidence_rate":1},{"cnt":[[120,1293],[1442,1293],[1442,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1293,"width":1322,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66d207ea47984147a41eeaf97f211490","type":"text","conversion_output":true,"text":"been biased as it was conducted by investigators associated with the study. \\({ }^{112}\\)","text_display":" been biased as it was conducted by investigators associated with the study. \\({ }^{112}\\)","confidence":1,"confidence_rate":1},{"cnt":[[120,1470],[1970,1470],[1970,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":1851,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a83974eef68c4f93a2cd1ed1bf586514","type":"text","conversion_output":true,"text":"Figure 6 shows the design elements of the ENGAGES trial that tend to be pragmatic (markers placed towards","text_display":"\n\nFigure 6 shows the design elements of the ENGAGES trial that tend to be pragmatic (markers placed towards","confidence":1,"confidence_rate":1},{"cnt":[[120,1510],[1970,1510],[1970,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1510,"width":1851,"height":48},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"409b9812f8cc46668475a0a5261af550","type":"text","conversion_output":true,"text":"the periphery) and elements that tend to be explanatory (markers placed towards the center). \\({ }^{111,113}\\) This figure","text_display":" the periphery) and elements that tend to be explanatory (markers placed towards the center). \\({ }^{111,113}\\) This figure","confidence":1,"confidence_rate":1},{"cnt":[[120,1555],[1979,1555],[1979,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1859,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"97a7f4ca89e7467fa4715c62e5ee68fa","type":"text","conversion_output":true,"text":"was generated from a median determination for each criterion (using a 1 to 5 ordinal scale from explanatory to","text_display":" was generated from a median determination for each criterion (using a 1 to 5 ordinal scale from explanatory to","confidence":1,"confidence_rate":1},{"cnt":[[120,1601],[1974,1601],[1974,1644],[120,1644]],"region":{"top_left_x":120,"top_left_y":1600,"width":1855,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"82f4fb62067e4eb3b18c4aac1a61ffe5","type":"text","conversion_output":true,"text":"pragmatic) from 18 independent raters on the study team. Aside from the intensity of patient follow-up and the","text_display":" pragmatic) from 18 independent raters on the study team. Aside from the intensity of patient follow-up and the","confidence":1,"confidence_rate":1},{"cnt":[[120,1646],[1944,1646],[1944,1689],[120,1689]],"region":{"top_left_x":120,"top_left_y":1645,"width":1825,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"12237c6796c94e3bbcdafbc7b593c601","type":"text","conversion_output":true,"text":"expertise needed to deliver the EEG-guided protocol, the ENGAGES study fulfills the criteria for a pragmatic","text_display":" expertise needed to deliver the EEG-guided protocol, the ENGAGES study fulfills the criteria for a pragmatic","confidence":1,"confidence_rate":1},{"cnt":[[120,1684],[415,1684],[415,1727],[120,1727]],"region":{"top_left_x":120,"top_left_y":1684,"width":295,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8aa94dff695f45e385cd477acc852368","type":"text","conversion_output":true,"text":"clinical trial. \\({ }^{111,112}\\)","text_display":" clinical trial. \\({ }^{111,112}\\)","confidence":1,"confidence_rate":1},{"cnt":[[116,1772],[561,1772],[561,1820],[116,1820]],"region":{"top_left_x":116,"top_left_y":1772,"width":445,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0db95ea9d9164a8d86c20433d53f65f8","type":"section_header","conversion_output":false,"children_ids":["e0d6539cb9c64791a3d08232c7df7b6d"],"text":"","text_display":""},{"cnt":[[120,1775],[556,1775],[556,1815],[120,1815]],"region":{"top_left_x":120,"top_left_y":1774,"width":437,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e0d6539cb9c64791a3d08232c7df7b6d","type":"text","conversion_output":true,"parent_id":"0db95ea9d9164a8d86c20433d53f65f8","text":"Strengths and Limitations","text_display":"\n\n\\section*{Strengths and Limitations}","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1979,1818],[1979,1863],[120,1863]],"region":{"top_left_x":120,"top_left_y":1817,"width":1859,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"460f5008889b4f538d205b356e731202","type":"text","conversion_output":true,"text":"The ENGAGES study has important strengths. It is largely a pragmatic randomized clinical trial conducted in a","text_display":"\n\nThe ENGAGES study has important strengths. It is largely a pragmatic randomized clinical trial conducted in a","confidence":1,"confidence_rate":1},{"cnt":[[120,1863],[1944,1863],[1944,1908],[120,1908]],"region":{"top_left_x":120,"top_left_y":1862,"width":1825,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"966bd11d53fb4dc194d206c6e42005c1","type":"text","conversion_output":true,"text":"high volume, real world clinical setting that incorporates an easy-to-implement intervention and examines an","text_display":" high volume, real world clinical setting that incorporates an easy-to-implement intervention and examines an","confidence":1,"confidence_rate":1},{"cnt":[[120,1908],[1981,1908],[1981,1953],[120,1953]],"region":{"top_left_x":120,"top_left_y":1907,"width":1861,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4305ff77210c48ed86a4bffb2e10cf1c","type":"text","conversion_output":true,"text":"outcome that is of tremendous importance to patients, healthcare providers and society. The ENGAGES study","text_display":" outcome that is of tremendous importance to patients, healthcare providers and society. The ENGAGES study","confidence":1,"confidence_rate":1},{"cnt":[[120,1951],[1841,1951],[1841,1996],[120,1996]],"region":{"top_left_x":120,"top_left_y":1950,"width":1722,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5698eec6eda74438b6ffd622751c4178","type":"text","conversion_output":true,"text":"can be conducted efficiently as many components of the proposed study are incorporated into existing","text_display":" can be conducted efficiently as many components of the proposed study are incorporated into existing","confidence":1,"confidence_rate":1},{"cnt":[[120,1994],[1916,1994],[1916,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":1797,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"15a3b465bb424b2995698bb72255ac32","type":"text","conversion_output":true,"text":"infrastructures and processes at Washington University: 1) enrollment will be integrated into the flow of the","text_display":" infrastructures and processes at Washington University: 1) enrollment will be integrated into the flow of the","confidence":0.9946355819702148,"confidence_rate":0.9999528181465605},{"cnt":[[120,2037],[1734,2037],[1734,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1614,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bda3f28fc3849de8fcb9dcdcc989c1e","type":"text","conversion_output":true,"text":"Center for Preoperative Assessment and Planning; 2) the conduct of the study will largely be by","text_display":" Center for Preoperative Assessment and Planning; 2) the conduct of the study will largely be by","confidence":0.9878351196101676,"confidence_rate":0.9998776127084712},{"cnt":[[120,2080],[1962,2080],[1962,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2079,"width":1842,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"99533e41507647b9aa555f0d0496964a","type":"text","conversion_output":true,"text":"anesthesiologists and certified registered nurse anesthetists in the course of their routine clinical work; and 3 )","text_display":" anesthesiologists and certified registered nurse anesthetists in the course of their routine clinical work; and 3 )","confidence":0.5273170471191406,"confidence_rate":0.9948106391081193}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-23","page":23,"lines":[{"cnt":[[120,159],[1985,159],[1985,202],[120,202]],"region":{"top_left_x":120,"top_left_y":158,"width":1866,"height":44},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f61954361a246d28bf9da0f14b2844d","type":"text","conversion_output":true,"text":"record. Most of the data collected for the trial will use existing infrastructure, and additional data will be entered","text_display":"\nrecord. Most of the data collected for the trial will use existing infrastructure, and additional data will be entered","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1931,202],[1931,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1812,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7ae2bf68525b4e04b3c08855b46dcc37","type":"text","conversion_output":true,"text":"using the REDCap resource that integrates well with our other data repositories. The feasibility of the trial is","text_display":" using the REDCap resource that integrates well with our other data repositories. The feasibility of the trial is","confidence":0.9990234375,"confidence_rate":0.9999916492686468},{"cnt":[[120,245],[1962,245],[1962,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1842,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"003846361eb2429ab94415a33b4bb8d6","type":"text","conversion_output":true,"text":"enhanced by participation of a multi-disciplinary team of investigators that has now established a track record","text_display":" enhanced by participation of a multi-disciplinary team of investigators that has now established a track record","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1983,288],[1983,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":1864,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9ad3b93d49b14d63b4fe7eb7833ea12e","type":"text","conversion_output":true,"text":"of collaboration and completion of major clinical trials. As the intervention is inexpensive and straightforward, if","text_display":" of collaboration and completion of major clinical trials. As the intervention is inexpensive and straightforward, if","confidence":1,"confidence_rate":1},{"cnt":[[120,335],[1992,335],[1992,380],[120,380]],"region":{"top_left_x":120,"top_left_y":335,"width":1872,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b7399414395489583dbd3af02aaf416","type":"text","conversion_output":true,"text":"the results of the study show compelling effectiveness, it will be logistically simple to implement and sustain the","text_display":" the results of the study show compelling effectiveness, it will be logistically simple to implement and sustain the","confidence":1,"confidence_rate":1},{"cnt":[[122,378],[1794,378],[1794,423],[122,423]],"region":{"top_left_x":122,"top_left_y":378,"width":1672,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5eb56503c05944cd9dc98514becb7f90","type":"text","conversion_output":true,"text":"EEG-guided anesthesia protocol at our institution and disseminate it nationally in the United States.","text_display":" EEG-guided anesthesia protocol at our institution and disseminate it nationally in the United States.","confidence":0.92138671875,"confidence_rate":0.9992278884128919},{"cnt":[[120,464],[1949,464],[1949,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1829,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e15d5ea09a434f7f8237ea68a5d5d867","type":"text","conversion_output":true,"text":"The following limitations should be considered. A single clinical trial should seldom be regarded as definitive.","text_display":"\n\nThe following limitations should be considered. A single clinical trial should seldom be regarded as definitive.","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1957,507],[1957,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1838,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7a84b24769be4f3d9c498749426e98ee","type":"text","conversion_output":true,"text":"As there is no clear estimate for the prior probability that EEG guidance of anesthesia prevents postoperative","text_display":" As there is no clear estimate for the prior probability that EEG guidance of anesthesia prevents postoperative","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,552],[1955,552],[1955,595],[120,595]],"region":{"top_left_x":120,"top_left_y":552,"width":1836,"height":44},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c6a2a137c10f40349b922a56c5257e16","type":"text","conversion_output":true,"text":"delirium, if the results of this trial do suggest that EEG-guidance of anesthesia might decrease delirium at the","text_display":" delirium, if the results of this trial do suggest that EEG-guidance of anesthesia might decrease delirium at the","confidence":1,"confidence_rate":1},{"cnt":[[120,640],[120,595],[1914,597],[1914,642]],"region":{"top_left_x":120,"top_left_y":595,"width":1795,"height":48},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3840b739d44b4d679106235a48bc2bcc","type":"text","conversion_output":true,"text":"arbitrary statistical threshold of \\(p <0.05\\), it will be necessary to replicate this finding in future studies. On the","text_display":" arbitrary statistical threshold of \\(p <0.05\\), it will be necessary to replicate this finding in future studies. On the","confidence":0.99951171875,"confidence_rate":0.9999961543341811},{"cnt":[[120,640],[1953,640],[1953,683],[120,683]],"region":{"top_left_x":120,"top_left_y":640,"width":1833,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac407dd5de9a4729b8d59a7d0d09277e","type":"text","conversion_output":true,"text":"other hand, even if the study finds a non-significant (at the arbitrary threshold of \\(p>0.05\\) ) decrease in delirium","text_display":" other hand, even if the study finds a non-significant (at the arbitrary threshold of \\(p>0.05\\) ) decrease in delirium","confidence":0.98388671875,"confidence_rate":0.9998668571284086},{"cnt":[[120,683],[1957,683],[1957,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":1838,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9b9cc32844e1447e842c84117c8a21d6","type":"text","conversion_output":true,"text":"in the EEG-guided group, it is likely that follow-up studies will be warranted to clarify whether or not there is a","text_display":" in the EEG-guided group, it is likely that follow-up studies will be warranted to clarify whether or not there is a","confidence":1,"confidence_rate":1},{"cnt":[[120,726],[1921,726],[1921,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":1801,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69929d87a2864cb29bcf4825e48b154b","type":"text","conversion_output":true,"text":"clinically meaningful reduction in delirium with EEG-guidance of anesthesia, and whether there are specific","text_display":" clinically meaningful reduction in delirium with EEG-guidance of anesthesia, and whether there are specific","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1899,769],[1899,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":1780,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c496b4cabbe54343a47b67a1933ecf1f","type":"text","conversion_output":true,"text":"patient populations that might especially benefit from this intervention. If EEG-guidance of anesthesia can","text_display":" patient populations that might especially benefit from this intervention. If EEG-guidance of anesthesia can","confidence":1,"confidence_rate":1},{"cnt":[[120,814],[1901,814],[1901,859],[120,859]],"region":{"top_left_x":120,"top_left_y":814,"width":1782,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cc2d57bc9fcb41aab4ee72e60a3cec29","type":"text","conversion_output":true,"text":"prevent postoperative delirium, demonstrating its effectiveness will depend on clinicians' adherence to the","text_display":" prevent postoperative delirium, demonstrating its effectiveness will depend on clinicians' adherence to the","confidence":1,"confidence_rate":1},{"cnt":[[120,855],[1944,855],[1944,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1825,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d4fd8228518c45ef8ec345b4fc2ad44e","type":"text","conversion_output":true,"text":"protocol. However, the inability to blind clinicians to the trial allocation group is a potential source of bias and","text_display":" protocol. However, the inability to blind clinicians to the trial allocation group is a potential source of bias and","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1867,902],[1867,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1747,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6f66f1dee78442b5a64cf0ecca98ba22","type":"text","conversion_output":true,"text":"confounding. We are attempting to confirm that clinicians do alter anesthetic management based on the","text_display":" confounding. We are attempting to confirm that clinicians do alter anesthetic management based on the","confidence":1,"confidence_rate":1},{"cnt":[[120,945],[1865,945],[1865,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1745,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"49de28e2508f49a9a47dc80501718dda","type":"text","conversion_output":true,"text":"intervention during the pilot phase of the study. The inclusion of patients in a clinical trial focused on the","text_display":" intervention during the pilot phase of the study. The inclusion of patients in a clinical trial focused on the","confidence":1,"confidence_rate":1},{"cnt":[[120,988],[1938,988],[1938,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1818,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8fa670c1b84843f8a74c3c2b43e172f9","type":"text","conversion_output":true,"text":"prevention of delirium, and the provision of practical educational information to patients and family members","text_display":" prevention of delirium, and the provision of practical educational information to patients and family members","confidence":1,"confidence_rate":1},{"cnt":[[120,1033],[1914,1033],[1914,1076],[120,1076]],"region":{"top_left_x":120,"top_left_y":1033,"width":1795,"height":44},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"20fd0e4855224e068c2475dfe92e9a84","type":"text","conversion_output":true,"text":"could decrease the incidence of postoperative delirium. Furthermore, if the multi-component intervention is","text_display":" could decrease the incidence of postoperative delirium. Furthermore, if the multi-component intervention is","confidence":1,"confidence_rate":1},{"cnt":[[120,1076],[1966,1076],[1966,1121],[120,1121]],"region":{"top_left_x":120,"top_left_y":1076,"width":1846,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"92f51fb3f22a494f84387129a06432e8","type":"text","conversion_output":true,"text":"successful in preventing falls and in improving quality of life, this could curtail our ability to detect an impact of","text_display":" successful in preventing falls and in improving quality of life, this could curtail our ability to detect an impact of","confidence":1,"confidence_rate":1},{"cnt":[[120,1121],[1944,1121],[1944,1164],[120,1164]],"region":{"top_left_x":120,"top_left_y":1121,"width":1825,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"89ccf00568844a01985628f45a2089b3","type":"text","conversion_output":true,"text":"the EEG-guided anesthetic protocol on these outcomes. In addition to the pragmatic structured chart review,","text_display":" the EEG-guided anesthetic protocol on these outcomes. In addition to the pragmatic structured chart review,","confidence":1,"confidence_rate":1},{"cnt":[[120,1164],[1966,1164],[1966,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1164,"width":1846,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a23bc67ded634f209d4c7a10aec96058","type":"text","conversion_output":true,"text":"there are two clinical assessment methods that will be used to diagnose delirium: the CAM-ICU and the CAM.","text_display":" there are two clinical assessment methods that will be used to diagnose delirium: the CAM-ICU and the CAM.","confidence":1,"confidence_rate":1},{"cnt":[[120,1207],[1931,1207],[1931,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1812,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"114670de97be4af7ba990d1b95644b5b","type":"text","conversion_output":true,"text":"The CAM-ICU is less sensitive than the CAM, but is the only instrument that has been validated for patients","text_display":" The CAM-ICU is less sensitive than the CAM, but is the only instrument that has been validated for patients","confidence":1,"confidence_rate":1},{"cnt":[[120,1250],[1944,1250],[1944,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1825,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bacbdfeab0784faeb59c414d49b27fc5","type":"text","conversion_output":true,"text":"who are non-verbal (i.e., with a breathing tube or tracheostomy in place). Based on our institutional data, the","text_display":" who are non-verbal (i.e., with a breathing tube or tracheostomy in place). Based on our institutional data, the","confidence":0.99853515625,"confidence_rate":0.9999873628584485},{"cnt":[[120,1296],[1927,1296],[1927,1338],[120,1338]],"region":{"top_left_x":120,"top_left_y":1295,"width":1808,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c7d8fc9cb907476cb3e79f565f7eb030","type":"text","conversion_output":true,"text":"vast majority of patients enrolled in the in the study will be extubated within the first two postoperative days.","text_display":" vast majority of patients enrolled in the in the study will be extubated within the first two postoperative days.","confidence":1,"confidence_rate":1},{"cnt":[[120,1336],[1858,1336],[1858,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1336,"width":1739,"height":48},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d493b34e4dc640a096fdc2e7f16ee9a8","type":"text","conversion_output":true,"text":"Therefore, most patients will have delirium assessments with the CAM, which is the more sensitive and","text_display":" Therefore, most patients will have delirium assessments with the CAM, which is the more sensitive and","confidence":1,"confidence_rate":1},{"cnt":[[120,1381],[1949,1381],[1949,1427],[120,1427]],"region":{"top_left_x":120,"top_left_y":1381,"width":1829,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"043fadbc33fd47e8a3ecf5ed5557c324","type":"text","conversion_output":true,"text":"specific instrument. We will also test whether intubation status modifies the result in secondary analysis. The","text_display":" specific instrument. We will also test whether intubation status modifies the result in secondary analysis. The","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[120,1427],[1983,1427],[1983,1472],[120,1472]],"region":{"top_left_x":120,"top_left_y":1426,"width":1864,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"df9375886b7c43859b6a8af536886ae2","type":"text","conversion_output":true,"text":"study design includes a 30-day and a 1-year follow up for patient reported outcomes, and incomplete follow-up","text_display":" study design includes a 30-day and a 1-year follow up for patient reported outcomes, and incomplete follow-up","confidence":0.7670736312866211,"confidence_rate":0.997676628801104},{"cnt":[[120,1470],[1919,1470],[1919,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":1799,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5ce088adb08c4b0a98ef7bb9f7f2e132","type":"text","conversion_output":true,"text":"is therefore a potential limitation. Based on our previous B-Unaware and BAG-RECALL studies, \\({ }^{40,41}\\) we are","text_display":" is therefore a potential limitation. Based on our previous B-Unaware and BAG-RECALL studies, \\({ }^{40,41}\\) we are","confidence":0.9960954189300537,"confidence_rate":0.9999673986660378},{"cnt":[[120,1512],[1972,1512],[1972,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":1853,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e979363060049b889c5dde0eb9de08a","type":"text","conversion_output":true,"text":"confident that we can achieve a 30 -day follow up rate of \\(>90 \\%\\). In our SATISFY-SOS cohort, the 1 -year follow","text_display":" confident that we can achieve a 30 -day follow up rate of \\(>90 \\%\\). In our SATISFY-SOS cohort, the 1 -year follow","confidence":0.9344779013190418,"confidence_rate":0.9994536388260662},{"cnt":[[120,1555],[1850,1555],[1850,1601],[120,1601]],"region":{"top_left_x":120,"top_left_y":1555,"width":1730,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"852d1a7f552e490dabd0b662ca1d7e06","type":"text","conversion_output":true,"text":"up has yielded approximately \\(66 \\%\\) response rate. We have performed sensitivity analysis in our power","text_display":" up has yielded approximately \\(66 \\%\\) response rate. We have performed sensitivity analysis in our power","confidence":0.9970703125,"confidence_rate":0.9999725799326211},{"cnt":[[120,1601],[1858,1601],[1858,1644],[120,1644]],"region":{"top_left_x":120,"top_left_y":1600,"width":1739,"height":44},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e510fbc00b174f3e88fcdc5b429fa22c","type":"text","conversion_output":true,"text":"calculations and have taken into account this potential attrition in our methods. Furthermore, we plan to","text_display":" calculations and have taken into account this potential attrition in our methods. Furthermore, we plan to","confidence":1,"confidence_rate":1},{"cnt":[[120,1644],[1899,1644],[1899,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1643,"width":1780,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e38ab37912140e79961ca711f4c1017","type":"text","conversion_output":true,"text":"enhance follow-up by using supplementary phone calls from members of the study team. As delirium is a","text_display":" enhance follow-up by using supplementary phone calls from members of the study team. As delirium is a","confidence":0.99951171875,"confidence_rate":0.9999953924587458},{"cnt":[[120,1689],[1858,1689],[1858,1734],[120,1734]],"region":{"top_left_x":120,"top_left_y":1688,"width":1739,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4be852e00e23463d9218167057aec5aa","type":"text","conversion_output":true,"text":"fluctuating disorder, there is a risk that it can be missed by periodic assessments. We are attempting to","text_display":" fluctuating disorder, there is a risk that it can be missed by periodic assessments. We are attempting to","confidence":0.99609375,"confidence_rate":0.9999644197300734},{"cnt":[[120,1732],[1955,1732],[1955,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1731,"width":1836,"height":46},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"66ffd3e289124dd8bc6301044d14435f","type":"text","conversion_output":true,"text":"mitigate this by assessing patients for delirium during a time of day (afternoon/evening) when delirium occurs","text_display":" mitigate this by assessing patients for delirium during a time of day (afternoon/evening) when delirium occurs","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1919,1775],[1919,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1799,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a328846ff62459e9fb0d6fbd71f0c3d","type":"text","conversion_output":true,"text":"more commonly. Furthermore, we are incorporating structured chart review, which has been validated as a","text_display":" more commonly. Furthermore, we are incorporating structured chart review, which has been validated as a","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1291,1818],[1291,1865],[120,1865]],"region":{"top_left_x":120,"top_left_y":1817,"width":1172,"height":48},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"01b524ff2b3f44529b4df8ec0b9fd36c","type":"text","conversion_output":true,"text":"complementary approach that increases the detection of delirium. \\({ }^{93,94}\\)","text_display":" complementary approach that increases the detection of delirium. \\({ }^{93,94}\\)","confidence":0.9980475902557373,"confidence_rate":0.9999758729061172},{"cnt":[[116,1899],[827,1899],[827,1953],[116,1953]],"region":{"top_left_x":116,"top_left_y":1899,"width":712,"height":54},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7d73bc1fff6b4564baeab54e226a0cfb","type":"section_header","conversion_output":false,"children_ids":["3b124102f6994bab8337791a84956d7c"],"text":"","text_display":""},{"cnt":[[120,1904],[823,1904],[823,1949],[120,1949]],"region":{"top_left_x":120,"top_left_y":1903,"width":703,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b124102f6994bab8337791a84956d7c","type":"text","conversion_output":true,"parent_id":"7d73bc1fff6b4564baeab54e226a0cfb","text":"Potential Benefits, Risks and Alternatives","text_display":"\n\n\\section*{Potential Benefits, Risks and Alternatives}","confidence":1,"confidence_rate":1},{"cnt":[[116,1985],[269,1985],[269,2030],[116,2030]],"region":{"top_left_x":116,"top_left_y":1985,"width":153,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"46bb0fdca53c40d9a77459d18cc82894","type":"section_header","conversion_output":false,"children_ids":["87bda88ab27e4f08a692d8ce22716ad8"],"text":"","text_display":""},{"cnt":[[120,1989],[264,1989],[264,2030],[120,2030]],"region":{"top_left_x":120,"top_left_y":1989,"width":145,"height":42},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"87bda88ab27e4f08a692d8ce22716ad8","type":"text","conversion_output":true,"parent_id":"46bb0fdca53c40d9a77459d18cc82894","text":"Benefits","text_display":"\n\n\\section*{Benefits}","confidence":1,"confidence_rate":1},{"cnt":[[122,2032],[1983,2032],[1983,2078],[122,2078]],"region":{"top_left_x":122,"top_left_y":2032,"width":1862,"height":46},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4904d8ca9c7e46a1b8a467cbd4bafab6","type":"text","conversion_output":true,"text":"If the hypotheses motivating this study are correct, patients who are randomized to receiving EEG-guidance of","text_display":"\n\nIf the hypotheses motivating this study are correct, patients who are randomized to receiving EEG-guidance of","confidence":0.998046875,"confidence_rate":0.9999828507186663},{"cnt":[[120,2075],[1953,2075],[1953,2123],[120,2123]],"region":{"top_left_x":120,"top_left_y":2075,"width":1833,"height":48},"line":44,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3c68b54482f46b9a43fea65bd2ec452","type":"text","conversion_output":true,"text":"anesthesia will have a lower chance of experiencing postoperative delirium and possibly also its downstream","text_display":" anesthesia will have a lower chance of experiencing postoperative delirium and possibly also its downstream","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-24","page":24,"lines":[{"cnt":[[120,202],[120,153],[1992,155],[1992,204]],"region":{"top_left_x":120,"top_left_y":152,"width":1872,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ff8af8b2d6004a60a9dd94ca80ef5c9d","type":"text","conversion_output":true,"text":"the presence of neuromuscular blocking agents have recently been highlighted. \\({ }^{114}\\) Titration of anesthesia in the","text_display":"\nthe presence of neuromuscular blocking agents have recently been highlighted. \\({ }^{114}\\) Titration of anesthesia in the","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1970,202],[1970,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1851,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ec9949be1fa34b4e9ca26735079797ff","type":"text","conversion_output":true,"text":"ENGAGES trial is therefore based primarily on the raw EEG waveform and only secondarily on the processed","text_display":" ENGAGES trial is therefore based primarily on the raw EEG waveform and only secondarily on the processed","confidence":1,"confidence_rate":1},{"cnt":[[120,245],[1962,245],[1962,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1842,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"efa8896ce5b74bd984c1f95544101eb9","type":"text","conversion_output":true,"text":"EEG index. Nonetheless, as a potential safety concern regarding the EEG-guided intervention remains that it","text_display":" EEG index. Nonetheless, as a potential safety concern regarding the EEG-guided intervention remains that it","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1953,288],[1953,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":1833,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c52a94999164af28866e3c1c3c52eb8","type":"text","conversion_output":true,"text":"could increase the incidence of intraoperative awareness, this outcome will be tracked postoperatively with a","text_display":" could increase the incidence of intraoperative awareness, this outcome will be tracked postoperatively with a","confidence":1,"confidence_rate":1},{"cnt":[[120,331],[1803,331],[1803,380],[120,380]],"region":{"top_left_x":120,"top_left_y":330,"width":1683,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a2e517baa4b24630afb1bf91621fa0a6","type":"text","conversion_output":true,"text":"modified Brice interview \\({ }^{115}\\) conducted within 48 hours of extubation. In addition, questions regarding","text_display":" modified Brice interview \\({ }^{115}\\) conducted within 48 hours of extubation. In addition, questions regarding","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1923,378],[1923,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1803,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c8628a917b28489e9011f0c8c0662589","type":"text","conversion_output":true,"text":"intraoperative awareness are also included in the SATISFY-SOS 1-month survey. A data-safety monitoring","text_display":" intraoperative awareness are also included in the SATISFY-SOS 1-month survey. A data-safety monitoring","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1970,421],[1970,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1851,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b72df589f7424aac82ddaa62daafd9e2","type":"text","conversion_output":true,"text":"committee will review adverse events with the PI and, in consultation with the institutional review board, might","text_display":" committee will review adverse events with the PI and, in consultation with the institutional review board, might","confidence":0.7297377586364746,"confidence_rate":0.9974417328829248},{"cnt":[[120,464],[1983,464],[1983,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1864,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1f059875a7c34a8eb186b3260f4e2cff","type":"text","conversion_output":true,"text":"recommend stoppage of the trial if awareness events appear to be increased in the intervention group. As part","text_display":" recommend stoppage of the trial if awareness events appear to be increased in the intervention group. As part","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1931,507],[1931,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1812,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"613ad614c2944be4b3a876a493cb38b9","type":"text","conversion_output":true,"text":"of the informed consent process for this study, patients will be informed of the rare risk of awareness. In the","text_display":" of the informed consent process for this study, patients will be informed of the rare risk of awareness. In the","confidence":0.99951171875,"confidence_rate":0.9999957896597419},{"cnt":[[120,552],[1876,552],[1876,597],[120,597]],"region":{"top_left_x":120,"top_left_y":552,"width":1756,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2f91ed9991ea47e2800490aeb03bc2ca","type":"text","conversion_output":true,"text":"unlikely event that serious side effects occur, they will be documented and will be reported to the human","text_display":" unlikely event that serious side effects occur, they will be documented and will be reported to the human","confidence":1,"confidence_rate":1},{"cnt":[[120,595],[1983,595],[1983,640],[120,640]],"region":{"top_left_x":120,"top_left_y":595,"width":1864,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"376d924768624b79b1596d9eb1ffea82","type":"text","conversion_output":true,"text":"research protection office and to the study's data safety monitoring board. Participants will not incur any study-","text_display":" research protection office and to the study's data safety monitoring board. Participants will not incur any study","confidence":0.9960966110229492,"confidence_rate":0.9999671347662701},{"cnt":[[120,640],[1472,640],[1472,685],[120,685]],"region":{"top_left_x":120,"top_left_y":640,"width":1352,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3810ba05ed8249ceb3efd55cf22ee0d0","type":"text","conversion_output":true,"text":"related expenses, nor will they be financially compensated for their participation.","text_display":"related expenses, nor will they be financially compensated for their participation.","confidence":1,"confidence_rate":1},{"cnt":[[116,722],[814,722],[814,776],[116,776]],"region":{"top_left_x":116,"top_left_y":721,"width":699,"height":55},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"83969b4191e34d99a0baf8950a0e568b","type":"section_header","conversion_output":false,"children_ids":["fe42d43ac7f943f1b8201041ec45e705"],"text":"","text_display":""},{"cnt":[[120,726],[810,726],[810,771],[120,771]],"region":{"top_left_x":120,"top_left_y":726,"width":690,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fe42d43ac7f943f1b8201041ec45e705","type":"text","conversion_output":true,"parent_id":"83969b4191e34d99a0baf8950a0e568b","text":"Minimization of Risks and Confidentiality","text_display":"\n\n\\section*{Minimization of Risks and Confidentiality}","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[1878,769],[1878,816],[120,816]],"region":{"top_left_x":120,"top_left_y":769,"width":1758,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"48bbc77048e043748be2af71759b4dac","type":"text","conversion_output":true,"text":"Necessary protected health information will only be shared with members of the research team. To help","text_display":"\n\nNecessary protected health information will only be shared with members of the research team. To help","confidence":1,"confidence_rate":1},{"cnt":[[120,812],[1888,812],[1888,862],[120,862]],"region":{"top_left_x":120,"top_left_y":812,"width":1769,"height":50},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9dc624e540ef4ff8b2e0f5bbb9408ebd","type":"text","conversion_output":true,"text":"protect confidentiality, research charts will be stored in a locked cabinet inside the locked research office.","text_display":" protect confidentiality, research charts will be stored in a locked cabinet inside the locked research office.","confidence":0.99951171875,"confidence_rate":0.9999957530481652},{"cnt":[[120,855],[1919,855],[1919,904],[120,904]],"region":{"top_left_x":120,"top_left_y":855,"width":1799,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85926178ecce4c31a4394e90df3c87bb","type":"text","conversion_output":true,"text":"Electronic data and demographic information will also be kept in a password-protected electronic database","text_display":" Electronic data and demographic information will also be kept in a password-protected electronic database","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1962,902],[1962,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1842,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f8295d23797846be87102fce591adfe0","type":"text","conversion_output":true,"text":"stored on the departmental network drive only accessible via password-protected departmental computers. A","text_display":" stored on the departmental network drive only accessible via password-protected departmental computers. A","confidence":1,"confidence_rate":1},{"cnt":[[120,945],[1884,945],[1884,990],[120,990]],"region":{"top_left_x":120,"top_left_y":945,"width":1765,"height":46},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4842b1a917ab4f21b7d44152476ccf95","type":"text","conversion_output":true,"text":"member of the research team will enter this information. Only code numbers will appear on any data and","text_display":" member of the research team will enter this information. Only code numbers will appear on any data and","confidence":1,"confidence_rate":1},{"cnt":[[120,988],[1970,988],[1970,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1851,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b0cfbc589dac42e28d6e153fa21a89e0","type":"text","conversion_output":true,"text":"documents used for evaluation or statistical analyses. Patients may choose not to participate in this study and","text_display":" documents used for evaluation or statistical analyses. Patients may choose not to participate in this study and","confidence":1,"confidence_rate":1},{"cnt":[[120,1031],[1154,1031],[1154,1079],[120,1079]],"region":{"top_left_x":120,"top_left_y":1031,"width":1034,"height":48},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4446405587654e66ab96d2a1ae87a9da","type":"text","conversion_output":true,"text":"there will be no penalty in terms of the care that they receive.","text_display":" there will be no penalty in terms of the care that they receive.","confidence":1,"confidence_rate":1},{"cnt":[[120,1119],[1929,1119],[1929,1167],[120,1167]],"region":{"top_left_x":120,"top_left_y":1119,"width":1810,"height":48},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cce125dccffc47a9a7d45748fbd7d65a","type":"text","conversion_output":true,"text":"The Division of Biostatistics Informatics Core at Washington University will be used for data processing and","text_display":"\n\nThe Division of Biostatistics Informatics Core at Washington University will be used for data processing and","confidence":1,"confidence_rate":1},{"cnt":[[120,1164],[1951,1164],[1951,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1164,"width":1831,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8bb91489ad2b49e59e0b0e8a84445fb8","type":"text","conversion_output":true,"text":"management. Washington University belongs to a consortium of institutional partners that work to maintain a","text_display":" management. Washington University belongs to a consortium of institutional partners that work to maintain a","confidence":1,"confidence_rate":1},{"cnt":[[120,1207],[1957,1207],[1957,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1838,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"08396981cb644865b55563d548d8222c","type":"text","conversion_output":true,"text":"software toolset and workflow methodology for electronic collection and management of research and clinical","text_display":" software toolset and workflow methodology for electronic collection and management of research and clinical","confidence":1,"confidence_rate":1},{"cnt":[[120,1250],[1888,1250],[1888,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1769,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"53064833ce7048d49ff1784cab672c73","type":"text","conversion_output":true,"text":"trial data. 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REDCap was developed specifically around HIPAA-Security","confidence":1,"confidence_rate":1},{"cnt":[[120,1601],[1869,1601],[1869,1646],[120,1646]],"region":{"top_left_x":120,"top_left_y":1600,"width":1750,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d081bd51cb6345129a46d339457c0911","type":"text","conversion_output":true,"text":"guidelines and is implemented and maintained according to Washington University guidelines. REDCap","text_display":" guidelines and is implemented and maintained according to Washington University guidelines. REDCap","confidence":1,"confidence_rate":1},{"cnt":[[120,1646],[1962,1646],[1962,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1645,"width":1842,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a87a0df8b2d74b0f95a10e28b677fed0","type":"text","conversion_output":true,"text":"currently supports >500 academic/non-profit consortium partners on six continents and 38,800 research end-","text_display":" currently supports >500 academic/non-profit consortium partners on six continents and 38,800 research end","confidence":0.54638671875,"confidence_rate":0.9945694989710968},{"cnt":[[120,1693],[230,1693],[230,1729],[120,1729]],"region":{"top_left_x":120,"top_left_y":1692,"width":110,"height":38},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"24654a2e28614f97b52faf274b9f324a","type":"text","conversion_output":true,"text":"users.","text_display":"users.","confidence":1,"confidence_rate":1},{"cnt":[[116,1770],[939,1770],[939,1824],[116,1824]],"region":{"top_left_x":116,"top_left_y":1770,"width":823,"height":55},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d2a50479b4dc48e39e2e52555f80fb40","type":"section_header","conversion_output":false,"children_ids":["f42ff37d5a2446aeb114744c0810e2d7"],"text":"","text_display":""},{"cnt":[[116,1775],[935,1775],[935,1820],[116,1820]],"region":{"top_left_x":116,"top_left_y":1774,"width":819,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f42ff37d5a2446aeb114744c0810e2d7","type":"text","conversion_output":true,"parent_id":"d2a50479b4dc48e39e2e52555f80fb40","text":"Adverse Event Reporting and Safety Monitoring","text_display":"\n\n\\section*{Adverse Event Reporting and Safety Monitoring}","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1858,1818],[1858,1867],[120,1867]],"region":{"top_left_x":120,"top_left_y":1817,"width":1739,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6d4125cd717a4c54a3b2d4e8714f0005","type":"text","conversion_output":true,"text":"The research team will monitor the study for adverse events. All serious adverse events (SAEs) will be","text_display":"\n\nThe research team will monitor the study for adverse events. All serious adverse events (SAEs) will be","confidence":0.99951171875,"confidence_rate":0.9999954355197808},{"cnt":[[120,1865],[1884,1865],[1884,1910],[120,1910]],"region":{"top_left_x":120,"top_left_y":1864,"width":1765,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ac4ef3efa19a45ed8854690e270d70c7","type":"text","conversion_output":true,"text":"reported to the IRB according to IRB stipulations. The monitoring plan for this study is appropriate for the","text_display":" reported to the IRB according to IRB stipulations. The monitoring plan for this study is appropriate for the","confidence":1,"confidence_rate":1},{"cnt":[[120,1908],[1878,1908],[1878,1953],[120,1953]],"region":{"top_left_x":120,"top_left_y":1907,"width":1758,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea090334e7ba44448711e1252a50be9d","type":"text","conversion_output":true,"text":"planned pragmatic trial. We have already conducted three large clinical studies including approximately","text_display":" planned pragmatic trial. We have already conducted three large clinical studies including approximately","confidence":1,"confidence_rate":1},{"cnt":[[120,1951],[1983,1951],[1983,1996],[120,1996]],"region":{"top_left_x":120,"top_left_y":1950,"width":1864,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2455a41f60334fbe81935d5a512bfe27","type":"text","conversion_output":true,"text":"28,000 patients, half of whom received general anesthesia with EEG-guidance. There were no adverse events","text_display":" 28,000 patients, half of whom received general anesthesia with EEG-guidance. There were no adverse events","confidence":1,"confidence_rate":1},{"cnt":[[120,1994],[1962,1994],[1962,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":1842,"height":46},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5f7edc64e74849b6b6de7cbca659be4b","type":"text","conversion_output":true,"text":"attributable to EEG-guidance of anesthesia in these studies \\({ }^{40-42}\\); it is unlikely that there will be adverse events","text_display":" attributable to EEG-guidance of anesthesia in these studies \\({ }^{40-42}\\); it is unlikely that there will be adverse events","confidence":1,"confidence_rate":1},{"cnt":[[120,2037],[1029,2037],[1029,2084],[120,2084]],"region":{"top_left_x":120,"top_left_y":2036,"width":910,"height":48},"line":43,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a4655690d5c647d99c3e04eb2bcdcaa6","type":"text","conversion_output":true,"text":"attributable to EEG-guidance in the ENGAGES study.","text_display":" attributable to EEG-guidance in the ENGAGES study.","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-25","page":25,"lines":[{"cnt":[[120,155],[1869,153],[1869,202],[120,204]],"region":{"top_left_x":120,"top_left_y":152,"width":1750,"height":53},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"282a2be5656a4c37b083f83290fe38bf","type":"text","conversion_output":true,"text":"safety or trial integrity. \\({ }^{118}\\) The DSMB will convene twice annually to review safety events. There will be a","text_display":"\nsafety or trial integrity. \\({ }^{118}\\) The DSMB will convene twice annually to review safety events. There will be a","confidence":1,"confidence_rate":1},{"cnt":[[120,200],[1927,200],[1927,247],[120,247]],"region":{"top_left_x":120,"top_left_y":199,"width":1808,"height":49},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1287846119034d2abf43ea4444b9c347","type":"text","conversion_output":true,"text":"provision for early stoppage for safety concerns, but not for efficacy or for futility. \\({ }^{116}\\) Trials that stop early for","text_display":" provision for early stoppage for safety concerns, but not for efficacy or for futility. \\({ }^{116}\\) Trials that stop early for","confidence":1,"confidence_rate":1},{"cnt":[[120,245],[1974,245],[1974,290],[120,290]],"region":{"top_left_x":120,"top_left_y":244,"width":1855,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9af75f3957e4bbdbfc7d60b9289a1cf","type":"text","conversion_output":true,"text":"benefit show implausibly large treatment effects, particularly when the number of events is small. \\({ }^{119}\\) Truncated","text_display":" benefit show implausibly large treatment effects, particularly when the number of events is small. \\({ }^{119}\\) Truncated","confidence":1,"confidence_rate":1},{"cnt":[[120,288],[1979,288],[1979,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":1859,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fb51479a9d7547e6a8ac798ed9d12df1","type":"text","conversion_output":true,"text":"trials have been associated with greater effect sizes than trials not stopped early, independent of the presence","text_display":" trials have been associated with greater effect sizes than trials not stopped early, independent of the presence","confidence":1,"confidence_rate":1},{"cnt":[[120,331],[1940,331],[1940,380],[120,380]],"region":{"top_left_x":120,"top_left_y":330,"width":1821,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c1603316a3f6426c96475606d38f081a","type":"text","conversion_output":true,"text":"of statistical stopping rules. \\({ }^{120}\\) The members of the DSMB shall have no direct involvement in the conduct of","text_display":" of statistical stopping rules. \\({ }^{120}\\) The members of the DSMB shall have no direct involvement in the conduct of","confidence":1,"confidence_rate":1},{"cnt":[[120,378],[1944,378],[1944,423],[120,423]],"region":{"top_left_x":120,"top_left_y":378,"width":1825,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"715ab5a7b9794dff80f5a66b2ac30d79","type":"text","conversion_output":true,"text":"the ENGAGES study. Neither shall they have financial, proprietary or professional conflicts of interest, which","text_display":" the ENGAGES study. Neither shall they have financial, proprietary or professional conflicts of interest, which","confidence":1,"confidence_rate":1},{"cnt":[[120,421],[1962,421],[1962,466],[120,466]],"region":{"top_left_x":120,"top_left_y":421,"width":1842,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"477a2e6d8b5f49ee9a3b832d557d8b4f","type":"text","conversion_output":true,"text":"may affect the impartial, independent decision-making responsibilities of the DSMB. \\({ }^{116,117}\\) All DSMB members","text_display":" may affect the impartial, independent decision-making responsibilities of the DSMB. \\({ }^{116,117}\\) All DSMB members","confidence":1,"confidence_rate":1},{"cnt":[[120,464],[1985,464],[1985,509],[120,509]],"region":{"top_left_x":120,"top_left_y":464,"width":1866,"height":46},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d61b10bd99fc4a0997edbfd7915edf61","type":"text","conversion_output":true,"text":"have signed a Conflict of Interest Certification to confirm no conflict exists. There are five people on the DSMB,","text_display":" have signed a Conflict of Interest Certification to confirm no conflict exists. There are five people on the DSMB,","confidence":1,"confidence_rate":1},{"cnt":[[120,507],[1979,507],[1979,552],[120,552]],"region":{"top_left_x":120,"top_left_y":507,"width":1859,"height":46},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cfe9ded0aaf448c198a21a2646daecca","type":"text","conversion_output":true,"text":"in order to optimize performance. \\({ }^{121}\\) The DSMB will be advisory rather than executive on the basis that it is the","text_display":" in order to optimize performance. \\({ }^{121}\\) The DSMB will be advisory rather than executive on the basis that it is the","confidence":1,"confidence_rate":1},{"cnt":[[120,552],[1796,552],[1796,597],[120,597]],"region":{"top_left_x":120,"top_left_y":552,"width":1677,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8261336f942e41f7ac57e8e0843cedda","type":"text","conversion_output":true,"text":"ENGAGES study investigators in partnership with the National Institute on Aging who are ultimately","text_display":" ENGAGES study investigators in partnership with the National Institute on Aging who are ultimately","confidence":1,"confidence_rate":1},{"cnt":[[120,593],[1059,593],[1059,642],[120,642]],"region":{"top_left_x":120,"top_left_y":592,"width":940,"height":51},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6fac89fcd3e54f7098a48f109a10c392","type":"text","conversion_output":true,"text":"responsible for the conduct of the trial (see Figure 7). \\({ }^{121}\\)","text_display":" responsible for the conduct of the trial (see Figure 7). \\({ }^{121}\\)","confidence":0.9990234375,"confidence_rate":0.9999862389728834},{"cnt":[[120,683],[767,683],[767,728],[120,728]],"region":{"top_left_x":120,"top_left_y":683,"width":647,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3f998f499e4d490cb9218139922b4a44","type":"text","conversion_output":true,"text":"Figure 7: ENGAGES trial organization","text_display":"\n\nFigure 7: ENGAGES trial organization","confidence":1,"confidence_rate":1},{"cnt":[[120,769],[625,769],[625,814],[120,814]],"region":{"top_left_x":120,"top_left_y":769,"width":506,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a3efecfc6cf344748fb449877a92d451","type":"text","conversion_output":true,"text":"Premature Study Termination","text_display":"\nPremature Study Termination","confidence":1,"confidence_rate":1},{"cnt":[[120,814],[1919,814],[1919,862],[120,862]],"region":{"top_left_x":120,"top_left_y":814,"width":1799,"height":48},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd81f163042e454eaa1cea5be6583aa5","type":"text","conversion_output":true,"text":"Patients in the EEG-guided anesthetic group will, on average, receive decreased concentrations of inhaled","text_display":"\nPatients in the EEG-guided anesthetic group will, on average, receive decreased concentrations of inhaled","confidence":1,"confidence_rate":1},{"cnt":[[120,857],[1914,857],[1914,904],[120,904]],"region":{"top_left_x":120,"top_left_y":857,"width":1795,"height":48},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a98bee5a10344721a1208fd28b817e1b","type":"text","conversion_output":true,"text":"anesthetic agents during their surgeries. Reduction of anesthetic administration using simultaneous EEG-","text_display":" anesthetic agents during their surgeries. Reduction of anesthetic administration using simultaneous EEG","confidence":1,"confidence_rate":1},{"cnt":[[120,902],[1996,902],[1996,947],[120,947]],"region":{"top_left_x":120,"top_left_y":902,"width":1876,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"74ad1f114b804b64898babfae5715568","type":"text","conversion_output":true,"text":"based monitoring of anesthetic depth has been previously described without reports of increased intraoperative","text_display":"based monitoring of anesthetic depth has been previously described without reports of increased intraoperative","confidence":1,"confidence_rate":1},{"cnt":[[120,943],[1974,943],[1974,990],[120,990]],"region":{"top_left_x":120,"top_left_y":943,"width":1855,"height":48},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4e6c746bf37343d59a3c8dea4fdb8e48","type":"text","conversion_output":true,"text":"awareness. \\({ }^{27,122}\\) However, it is theoretically plausible that a significantly higher rate of awareness events could","text_display":" awareness. \\({ }^{27,122}\\) However, it is theoretically plausible that a significantly higher rate of awareness events could","confidence":1,"confidence_rate":1},{"cnt":[[120,988],[1981,988],[1981,1033],[120,1033]],"region":{"top_left_x":120,"top_left_y":988,"width":1861,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8d7a4e965d7a47f28cee3053f7381e8c","type":"text","conversion_output":true,"text":"occur in a cohort that on average receives lower anesthetic concentrations. Therefore, we propose comparing","text_display":" occur in a cohort that on average receives lower anesthetic concentrations. Therefore, we propose comparing","confidence":1,"confidence_rate":1},{"cnt":[[120,1033],[1820,1033],[1820,1076],[120,1076]],"region":{"top_left_x":120,"top_left_y":1033,"width":1700,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6afb195a92dc49a5bdadaa5b2aa697b6","type":"text","conversion_output":true,"text":"the incidence of intraoperative awareness reports in the EEG-guided and usual care groups. We will","text_display":" the incidence of intraoperative awareness reports in the EEG-guided and usual care groups. We will","confidence":1,"confidence_rate":1},{"cnt":[[120,1076],[1944,1076],[1944,1121],[120,1121]],"region":{"top_left_x":120,"top_left_y":1076,"width":1825,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a10ca8bfbb0423fa89d3da1813493bc","type":"text","conversion_output":true,"text":"recommend to the DSMB that this occur after 600 patients have been enrolled. A one-tailed comparison will","text_display":" recommend to the DSMB that this occur after 600 patients have been enrolled. A one-tailed comparison will","confidence":1,"confidence_rate":1},{"cnt":[[120,1164],[120,1118],[1824,1120],[1824,1167]],"region":{"top_left_x":120,"top_left_y":1117,"width":1705,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0edd0b5f15a4452186cb1890c71bba08","type":"text","conversion_output":true,"text":"be used to compare the incidences of awareness in the groups, and consideration should be given to","text_display":" be used to compare the incidences of awareness in the groups, and consideration should be given to","confidence":1,"confidence_rate":1},{"cnt":[[120,1164],[1803,1164],[1803,1210],[120,1210]],"region":{"top_left_x":120,"top_left_y":1164,"width":1683,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"413e013651534ffc992b4becca42fd00","type":"text","conversion_output":true,"text":"terminating the study if the EEG-guided cohort has a significantly greater incidence of intraoperative","text_display":" terminating the study if the EEG-guided cohort has a significantly greater incidence of intraoperative","confidence":0.99853515625,"confidence_rate":0.9999862999285899},{"cnt":[[120,1207],[1949,1207],[1949,1253],[120,1253]],"region":{"top_left_x":120,"top_left_y":1207,"width":1829,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6e2b9cadd97e4a80bc92366b06dcd425","type":"text","conversion_output":true,"text":"awareness compared with the standard of care group with a \\(p\\) value \\(<0.05\\). In making recommendations, the","text_display":" awareness compared with the standard of care group with a \\(p\\) value \\(<0.05\\). In making recommendations, the","confidence":0.9496314073207941,"confidence_rate":0.9995506978189044},{"cnt":[[120,1250],[1884,1250],[1884,1296],[120,1296]],"region":{"top_left_x":120,"top_left_y":1250,"width":1765,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e7094f73be274b838e0feceb10306c27","type":"text","conversion_output":true,"text":"DSMB could take into consideration the severity of the awareness experiences, including reports of pain,","text_display":" DSMB could take into consideration the severity of the awareness experiences, including reports of pain,","confidence":1,"confidence_rate":1},{"cnt":[[120,1293],[1962,1293],[1962,1341],[120,1341]],"region":{"top_left_x":120,"top_left_y":1293,"width":1842,"height":48},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"606bd6f64cd04f318b1227f996d58720","type":"text","conversion_output":true,"text":"paralysis and distress. \\({ }^{123}\\) Apart from intraoperative awareness, it is not currently hypothesized that decreased","text_display":" paralysis and distress. \\({ }^{123}\\) Apart from intraoperative awareness, it is not currently hypothesized that decreased","confidence":1,"confidence_rate":1},{"cnt":[[120,1336],[1876,1336],[1876,1384],[120,1384]],"region":{"top_left_x":120,"top_left_y":1336,"width":1756,"height":48},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"21e1488c2d634a9b94568fb6a401a7c9","type":"text","conversion_output":true,"text":"anesthetic administration is associated with clinically relevant adverse outcomes (e.g. death, myocardial","text_display":" anesthetic administration is associated with clinically relevant adverse outcomes (e.g. death, myocardial","confidence":1,"confidence_rate":1},{"cnt":[[120,1384],[1766,1384],[1766,1429],[120,1429]],"region":{"top_left_x":120,"top_left_y":1383,"width":1647,"height":46},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b503bf8e03ad4dc0a21621d3c4dc008e","type":"text","conversion_output":true,"text":"infarction, stroke). It is possible that decreases anesthetic administration might be associated with","text_display":" infarction, stroke). It is possible that decreases anesthetic administration might be associated with","confidence":1,"confidence_rate":1},{"cnt":[[120,1427],[1910,1427],[1910,1472],[120,1472]],"region":{"top_left_x":120,"top_left_y":1426,"width":1790,"height":46},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"33d6b5a11e284c9aaf51e4126ddb8f67","type":"text","conversion_output":true,"text":"intraoperative patient movement, or with increased intraoperative blood pressure and heart rate. However,","text_display":" intraoperative patient movement, or with increased intraoperative blood pressure and heart rate. However,","confidence":1,"confidence_rate":1},{"cnt":[[120,1470],[1962,1470],[1962,1515],[120,1515]],"region":{"top_left_x":120,"top_left_y":1469,"width":1842,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"425e543273eb4df6a0ed404708bd1f12","type":"text","conversion_output":true,"text":"these are surrogate measures with unclear clinical relevance, which should not therefore impact a decision to","text_display":" these are surrogate measures with unclear clinical relevance, which should not therefore impact a decision to","confidence":1,"confidence_rate":1},{"cnt":[[120,1512],[552,1512],[552,1558],[120,1558]],"region":{"top_left_x":120,"top_left_y":1512,"width":433,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5d070bdf6f7648fdacfdf6007e82f482","type":"text","conversion_output":true,"text":"terminate the study early.","text_display":" terminate the study early.","confidence":1,"confidence_rate":1},{"cnt":[[120,1601],[1893,1601],[1893,1646],[120,1646]],"region":{"top_left_x":120,"top_left_y":1600,"width":1773,"height":46},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"09a46041996d4b06ad09eb9908aeee6f","type":"text","conversion_output":true,"text":"We recommend to the DSMB not performing an interim analysis of delirium rates for any consideration of","text_display":"\n\nWe recommend to the DSMB not performing an interim analysis of delirium rates for any consideration of","confidence":1,"confidence_rate":1},{"cnt":[[120,1646],[1927,1646],[1927,1691],[120,1691]],"region":{"top_left_x":120,"top_left_y":1645,"width":1808,"height":46},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5cb77dacb60466fb9d1260e7e798307","type":"text","conversion_output":true,"text":"termination. Currently available data support the possibility that an EEG-guided anesthetic management to","text_display":" termination. Currently available data support the possibility that an EEG-guided anesthetic management to","confidence":1,"confidence_rate":1},{"cnt":[[120,1689],[1953,1689],[1953,1734],[120,1734]],"region":{"top_left_x":120,"top_left_y":1688,"width":1833,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d6fd4e51a8724cb083b4e1d4bb5e70cc","type":"text","conversion_output":true,"text":"reduce anesthetic administration might decrease the incidence of postoperative delirium or have no effect on","text_display":" reduce anesthetic administration might decrease the incidence of postoperative delirium or have no effect on","confidence":1,"confidence_rate":1},{"cnt":[[120,1729],[1953,1729],[1953,1777],[120,1777]],"region":{"top_left_x":120,"top_left_y":1729,"width":1833,"height":48},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdae299b75774516a72aee8500c51b76","type":"text","conversion_output":true,"text":"this outcome. \\({ }^{26-29}\\) Conversely, the possible finding of a higher incidence of delirium in the EEG-guided cohort","text_display":" this outcome. \\({ }^{26-29}\\) Conversely, the possible finding of a higher incidence of delirium in the EEG-guided cohort","confidence":1,"confidence_rate":1},{"cnt":[[120,1775],[1876,1775],[1876,1820],[120,1820]],"region":{"top_left_x":120,"top_left_y":1774,"width":1756,"height":46},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a283153fe910479abaa6626ab894a383","type":"text","conversion_output":true,"text":"would conflict with current evidence. When interpreted in the context of existing evidence, the finding of","text_display":" would conflict with current evidence. When interpreted in the context of existing evidence, the finding of","confidence":1,"confidence_rate":1},{"cnt":[[120,1818],[1953,1818],[1953,1865],[120,1865]],"region":{"top_left_x":120,"top_left_y":1817,"width":1833,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"77cbbab9e4664afaa6a527df42a95484","type":"text","conversion_output":true,"text":"significantly disparate incidences of postoperative delirium in a partially completed ENGAGES trial would not","text_display":" significantly disparate incidences of postoperative delirium in a partially completed ENGAGES trial would not","confidence":1,"confidence_rate":1},{"cnt":[[120,1863],[1837,1863],[1837,1910],[120,1910]],"region":{"top_left_x":120,"top_left_y":1862,"width":1717,"height":48},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b24d66671aba4e3fb2770fde69d8cb89","type":"text","conversion_output":true,"text":"provide a sufficient evidence base to change the standard of practice for anesthetic guidance of these","text_display":" provide a sufficient evidence base to change the standard of practice for anesthetic guidance of these","confidence":0.99560546875,"confidence_rate":0.9999588399537807},{"cnt":[[120,1908],[269,1908],[269,1953],[120,1953]],"region":{"top_left_x":120,"top_left_y":1907,"width":149,"height":46},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d5beb8d403fd459eaf256bf0bf1af4c6","type":"text","conversion_output":true,"text":"patients.","text_display":" patients.","confidence":1,"confidence_rate":1},{"cnt":[[116,1989],[296,1989],[296,2041],[116,2041]],"region":{"top_left_x":116,"top_left_y":1989,"width":181,"height":53},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"73e25ecbcfbb495c965867a1fd9ec9ce","type":"section_header","conversion_output":false,"children_ids":["e51fb95e1e2140c18c366f23542acd78"],"text":"","text_display":""},{"cnt":[[120,1994],[294,1994],[294,2039],[120,2039]],"region":{"top_left_x":120,"top_left_y":1993,"width":175,"height":46},"line":40,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e51fb95e1e2140c18c366f23542acd78","type":"text","conversion_output":true,"parent_id":"73e25ecbcfbb495c965867a1fd9ec9ce","text":"Indemnity","text_display":"\n\n\\section*{Indemnity}","confidence":1,"confidence_rate":1},{"cnt":[[120,2037],[1979,2037],[1979,2082],[120,2082]],"region":{"top_left_x":120,"top_left_y":2036,"width":1859,"height":46},"line":41,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9e7e08ceb924cafa27d9b601dc5a825","type":"text","conversion_output":true,"text":"Washington University School of Medicine is responsible for any non-negligent damage incurred as a result of","text_display":"\n\nWashington University School of Medicine is responsible for any non-negligent damage incurred as a result of","confidence":1,"confidence_rate":1},{"cnt":[[120,2082],[1904,2082],[1904,2125],[120,2125]],"region":{"top_left_x":120,"top_left_y":2081,"width":1784,"height":44},"line":42,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"54a38a2b132249d7ad9a1e0ae96b4af6","type":"text","conversion_output":true,"text":"participating in the ENGAGES Trial. The indemnity is renewed on an annual basis. Washington University","text_display":" participating in the ENGAGES Trial. The indemnity is renewed on an annual basis. Washington University","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-26","page":26,"lines":[{"cnt":[[120,159],[1964,159],[1964,204],[120,204]],"region":{"top_left_x":120,"top_left_y":158,"width":1844,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7586dde412df49179eea9e99af53b671","type":"text","conversion_output":true,"text":"trial in a peer-reviewed journal. Dissemination of results to study participants and their family members will be","text_display":"\ntrial in a peer-reviewed journal. Dissemination of results to study participants and their family members will be","confidence":1,"confidence_rate":1},{"cnt":[[120,202],[1897,202],[1897,247],[120,247]],"region":{"top_left_x":120,"top_left_y":201,"width":1778,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1588e09a7b7e4453bb2ce1f7be17c3a6","type":"text","conversion_output":true,"text":"available upon request. Updates and results of the study will be available to the public at clinicaltrials.gov.","text_display":" available upon request. Updates and results of the study will be available to the public at clinicaltrials.gov.","confidence":1,"confidence_rate":1},{"cnt":[[116,288],[350,288],[350,335],[116,335]],"region":{"top_left_x":116,"top_left_y":287,"width":235,"height":49},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c95e66f0dee4a93ac8cb4f9e4f50768","type":"section_header","conversion_output":false,"children_ids":["a262c673bb7d479580e2045384cfff86"],"text":"","text_display":""},{"cnt":[[120,288],[346,288],[346,333],[120,333]],"region":{"top_left_x":120,"top_left_y":287,"width":226,"height":47},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a262c673bb7d479580e2045384cfff86","type":"text","conversion_output":true,"parent_id":"3c95e66f0dee4a93ac8cb4f9e4f50768","text":"Addendums","text_display":"\n\n\\section*{Addendums}","confidence":1,"confidence_rate":1},{"cnt":[[120,374],[606,374],[606,423],[120,423]],"region":{"top_left_x":120,"top_left_y":373,"width":486,"height":51},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9a4998b4a692466982452957e46290fe","type":"section_header","conversion_output":false,"children_ids":["13432f88446741879d13a4ecbfa8a033"],"text":"","text_display":""},{"cnt":[[125,378],[604,378],[604,421],[125,421]],"region":{"top_left_x":124,"top_left_y":378,"width":480,"height":44},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13432f88446741879d13a4ecbfa8a033","type":"text","conversion_output":true,"parent_id":"9a4998b4a692466982452957e46290fe","text":"Pre-Specified Sub-Studies","text_display":"\n\n\\section*{Pre-Specified Sub-Studies}","confidence":1,"confidence_rate":1},{"cnt":[[185,464],[810,464],[810,509],[185,509]],"region":{"top_left_x":184,"top_left_y":464,"width":626,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"95a9b0d92c594bac86e96b12280dc27c","type":"text","conversion_output":true,"text":"a) Duration and Severity of Delirium","text_display":"\na) Duration and Severity of Delirium","confidence":1,"confidence_rate":1},{"cnt":[[245,509],[1962,509],[1962,552],[245,552]],"region":{"top_left_x":244,"top_left_y":509,"width":1718,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"fdc51a20a733486c9928c107936b3782","type":"text","conversion_output":true,"text":"In addition to the incidence of delirium (the primary outcome of the ENGAGES study), other outcomes","text_display":"\n\nIn addition to the incidence of delirium (the primary outcome of the ENGAGES study), other outcomes","confidence":1,"confidence_rate":1},{"cnt":[[245,554],[1992,554],[1992,595],[245,595]],"region":{"top_left_x":244,"top_left_y":554,"width":1748,"height":42},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"4eb831a1ca7841a88a76a88d6d5ffe36","type":"text","conversion_output":true,"text":"of interest will be the duration of delirium and the severity of delirium, both of which have been shown to","text_display":" of interest will be the duration of delirium and the severity of delirium, both of which have been shown to","confidence":1,"confidence_rate":1},{"cnt":[[245,595],[1992,595],[1992,640],[245,640]],"region":{"top_left_x":244,"top_left_y":595,"width":1748,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07bd2752049041af9c9a96e9ab82f7e1","type":"text","conversion_output":true,"text":"have prognostic importance. \\({ }^{124-128}\\) The severity of delirium will be scored using the CAM-Severity (CAM-","text_display":" have prognostic importance. \\({ }^{124-128}\\) The severity of delirium will be scored using the CAM-Severity (CAM","confidence":1,"confidence_rate":1},{"cnt":[[245,640],[1813,640],[1813,683],[245,683]],"region":{"top_left_x":244,"top_left_y":640,"width":1570,"height":44},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2184ab09f0e4434aa3e6a9a9f92e4147","type":"text","conversion_output":true,"text":"\\(S )\\) metric, which has specifically been shown to be strongly associated with clinically relevant","text_display":"\\(S )\\) metric, which has specifically been shown to be strongly associated with clinically relevant","confidence":0.874969482421875,"confidence_rate":0.9986913837461235},{"cnt":[[245,683],[1938,683],[1938,728],[245,728]],"region":{"top_left_x":244,"top_left_y":683,"width":1694,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"07282e51ed8d46cbb668d5629cb7523c","type":"text","conversion_output":true,"text":"outcomes. \\({ }^{128}\\) Delirium will also be assessed postoperatively on the day of surgery, when patients are","text_display":" outcomes. \\({ }^{128}\\) Delirium will also be assessed postoperatively on the day of surgery, when patients are","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[776,726],[776,771],[245,771]],"region":{"top_left_x":244,"top_left_y":726,"width":532,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e7c7b9dd17e48519872d71dcb438ca0","type":"text","conversion_output":true,"text":"sufficiently awake (RASS > -4).","text_display":" sufficiently awake (RASS > -4).","confidence":0.99951171875,"confidence_rate":0.9999864334115239},{"cnt":[[185,814],[1846,814],[1846,857],[185,857]],"region":{"top_left_x":184,"top_left_y":814,"width":1662,"height":44},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b4a257722724771b5899f9c5c5d36b0","type":"text","conversion_output":true,"text":"b) Agreements among the FAM-CAM, researchers' delirium assessments and patient perceptions","text_display":"\nb) Agreements among the FAM-CAM, researchers' delirium assessments and patient perceptions","confidence":1,"confidence_rate":1},{"cnt":[[245,859],[1972,859],[1972,900],[245,900]],"region":{"top_left_x":244,"top_left_y":859,"width":1729,"height":42},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25b3e97eb41d4822b04d07dc039a828e","type":"text","conversion_output":true,"text":"The ENGAGES study is a patient-centered study. As such, the active involvement of patients and their","text_display":" The ENGAGES study is a patient-centered study. As such, the active involvement of patients and their","confidence":1,"confidence_rate":1},{"cnt":[[245,902],[1987,902],[1987,947],[245,947]],"region":{"top_left_x":244,"top_left_y":902,"width":1744,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a254384a9c434270a6291fb1b1fc5847","type":"text","conversion_output":true,"text":"families is an important component. The Family Confusion Assessment Method (FAM-CAM) instrument","text_display":" families is an important component. The Family Confusion Assessment Method (FAM-CAM) instrument","confidence":1,"confidence_rate":1},{"cnt":[[245,947],[1970,947],[1970,990],[245,990]],"region":{"top_left_x":244,"top_left_y":947,"width":1727,"height":44},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"06c3effd76b54665b2a3fc1860d8edca","type":"text","conversion_output":true,"text":"has previously been shown to have good agreement with the CAM and with DSM-IV diagnostic criteria","text_display":" has previously been shown to have good agreement with the CAM and with DSM-IV diagnostic criteria","confidence":1,"confidence_rate":1},{"cnt":[[245,988],[1968,988],[1968,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":988,"width":1724,"height":46},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e55337abb91744ff9430f47175140e09","type":"text","conversion_output":true,"text":"in patients with cognitive impairment and in hospitalized patients. \\({ }^{103,104}\\) The utility of the FAM-CAM has","text_display":" in patients with cognitive impairment and in hospitalized patients. \\({ }^{103,104}\\) The utility of the FAM-CAM has","confidence":0.99951171875,"confidence_rate":0.9999959636403931},{"cnt":[[245,1033],[1934,1033],[1934,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1033,"width":1690,"height":44},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e99d9001cb34428f87e60c118b0a4a8b","type":"text","conversion_output":true,"text":"not been established in postoperative patients; however it has been successfully implemented in the","text_display":" not been established in postoperative patients; however it has been successfully implemented in the","confidence":0.998046875,"confidence_rate":0.9999812017648063},{"cnt":[[247,1074],[1927,1074],[1927,1119],[247,1119]],"region":{"top_left_x":247,"top_left_y":1074,"width":1681,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a0b153b332f74d79af5af06502956dd0","type":"text","conversion_output":true,"text":"postoperative setting in the ongoing PODCAST clinical trial. \\({ }^{129}\\) Patients will also complete a delirium","text_display":" postoperative setting in the ongoing PODCAST clinical trial. \\({ }^{129}\\) Patients will also complete a delirium","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1914,1121],[1914,1164],[245,1164]],"region":{"top_left_x":244,"top_left_y":1121,"width":1671,"height":44},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"52a6b805fce940279917be3f91bcb25e","type":"text","conversion_output":true,"text":"self-assessment questionnaire (Appendix). Both the FAM-CAM assessments and the patients' self-","text_display":" self-assessment questionnaire (Appendix). Both the FAM-CAM assessments and the patients' self","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1515,1164],[1515,1207],[245,1207]],"region":{"top_left_x":244,"top_left_y":1164,"width":1271,"height":44},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"25717b86390441c79de61fc8bfd2375f","type":"text","conversion_output":true,"text":"assessments will be compared with the researchers' delirium assessments.","text_display":"assessments will be compared with the researchers' delirium assessments.","confidence":0.9990234375,"confidence_rate":0.9999873112539076},{"cnt":[[185,1250],[1953,1250],[1953,1296],[185,1296]],"region":{"top_left_x":184,"top_left_y":1250,"width":1769,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f7b566c17a964929baceeb1d8e3d0da3","type":"text","conversion_output":true,"text":"c) Duration or recurrence of delirium after hospital discharge as measured by the FAM-CAM and patient","text_display":"\nc) Duration or recurrence of delirium after hospital discharge as measured by the FAM-CAM and patient","confidence":0.9975595474243164,"confidence_rate":0.9999769489889436},{"cnt":[[245,1296],[449,1296],[449,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1295,"width":206,"height":44},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3c581ea8042c416cbb503db4c1356206","type":"text","conversion_output":true,"text":"perceptions","text_display":" perceptions","confidence":1,"confidence_rate":1},{"cnt":[[245,1341],[1841,1341],[1841,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1340,"width":1598,"height":42},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"687838f2630e46bd9d847f4c9d9425ea","type":"text","conversion_output":true,"text":"Little is currently known about either duration of delirium or recurrence of delirium after hospital","text_display":"\nLittle is currently known about either duration of delirium or recurrence of delirium after hospital","confidence":1,"confidence_rate":1},{"cnt":[[245,1384],[1893,1384],[1893,1427],[245,1427]],"region":{"top_left_x":244,"top_left_y":1383,"width":1649,"height":44},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7e6e6de97fe4472eab3472377ca1499f","type":"text","conversion_output":true,"text":"discharge in postoperative patients. The FAM-CAM and patient self-reports will be used to assess","text_display":" discharge in postoperative patients. The FAM-CAM and patient self-reports will be used to assess","confidence":1,"confidence_rate":1},{"cnt":[[245,1427],[531,1427],[531,1463],[245,1463]],"region":{"top_left_x":244,"top_left_y":1426,"width":287,"height":38},"line":27,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3b60555a13f24e968036f636ae29fe68","type":"text","conversion_output":true,"text":"these outcomes.","text_display":" these outcomes.","confidence":1,"confidence_rate":1},{"cnt":[[185,1515],[1137,1515],[1137,1558],[185,1558]],"region":{"top_left_x":184,"top_left_y":1514,"width":953,"height":44},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dac7cc864d7145d7bbc9ddf7f3b15471","type":"text","conversion_output":true,"text":"d) Clinically relevant outcomes associated with delirium","text_display":"\nd) Clinically relevant outcomes associated with delirium","confidence":1,"confidence_rate":1},{"cnt":[[245,1560],[1757,1560],[1757,1601],[245,1601]],"region":{"top_left_x":244,"top_left_y":1559,"width":1514,"height":42},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8a0678820834d4cb7e3c0a4876780d7","type":"text","conversion_output":true,"text":"Delirium incidence, duration and severity have all been shown to be associated with other","text_display":"\n\nDelirium incidence, duration and severity have all been shown to be associated with other","confidence":1,"confidence_rate":1},{"cnt":[[247,1603],[1914,1603],[1914,1644],[247,1644]],"region":{"top_left_x":247,"top_left_y":1602,"width":1668,"height":42},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"3d3ac2694b5447558932490e4cfc91a6","type":"text","conversion_output":true,"text":"(downstream) clinically relevant outcomes, including mortality, length of ICU stay, length of hospital","text_display":" (downstream) clinically relevant outcomes, including mortality, length of ICU stay, length of hospital","confidence":1,"confidence_rate":1},{"cnt":[[245,1646],[1955,1646],[1955,1689],[245,1689]],"region":{"top_left_x":244,"top_left_y":1645,"width":1712,"height":44},"line":31,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a9fbecba0a4747838a37a40c91c4e091","type":"text","conversion_output":true,"text":"stay, falls, cognitive decline and functional decline. In the ENGAGES study, these associations will be","text_display":" stay, falls, cognitive decline and functional decline. In the ENGAGES study, these associations will be","confidence":1,"confidence_rate":1},{"cnt":[[245,1689],[1910,1689],[1910,1732],[245,1732]],"region":{"top_left_x":244,"top_left_y":1688,"width":1666,"height":44},"line":32,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0e9d41c4ab734cd290eff699bbb80fdd","type":"text","conversion_output":true,"text":"explored. The data on downstream outcomes will be obtained from hospital records or from patient","text_display":" explored. The data on downstream outcomes will be obtained from hospital records or from patient","confidence":1,"confidence_rate":1},{"cnt":[[245,1732],[1796,1732],[1796,1777],[245,1777]],"region":{"top_left_x":244,"top_left_y":1731,"width":1553,"height":46},"line":33,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"680dcdad93b54526a20e81351939b0d7","type":"text","conversion_output":true,"text":"reported outcomes measures that are collected as part of the ongoing SATISFY-SOS study.","text_display":" reported outcomes measures that are collected as part of the ongoing SATISFY-SOS study.","confidence":1,"confidence_rate":1},{"cnt":[[185,1818],[1291,1818],[1291,1863],[185,1863]],"region":{"top_left_x":184,"top_left_y":1817,"width":1108,"height":46},"line":34,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b4fd2cbf9f554217bea27b6ed09e84d0","type":"text","conversion_output":true,"text":"e) Comparison of patient-reported and observational pain scores","text_display":"\ne) Comparison of patient-reported and observational pain scores","confidence":1,"confidence_rate":1},{"cnt":[[245,1865],[1901,1865],[1901,1906],[245,1906]],"region":{"top_left_x":244,"top_left_y":1864,"width":1658,"height":42},"line":35,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"9562df009f474c9db5d3c25fae720bc1","type":"text","conversion_output":true,"text":"It is likely that patients with delirium are less able to convey verbally the extent to which they are in","text_display":"\n\nIt is likely that patients with delirium are less able to convey verbally the extent to which they are in","confidence":1,"confidence_rate":1},{"cnt":[[245,1904],[1893,1904],[1893,1951],[245,1951]],"region":{"top_left_x":244,"top_left_y":1903,"width":1649,"height":48},"line":36,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ce075f1a4dc74cf196554eae3e9a8ff7","type":"text","conversion_output":true,"text":"pain. \\({ }^{130}\\) Given that postoperative delirium is common and may relate to uncontrolled pain, this has","text_display":" pain. \\({ }^{130}\\) Given that postoperative delirium is common and may relate to uncontrolled pain, this has","confidence":1,"confidence_rate":1},{"cnt":[[245,1951],[1921,1951],[1921,1996],[245,1996]],"region":{"top_left_x":244,"top_left_y":1950,"width":1677,"height":46},"line":37,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"dd7f7b02fa9f47c5bd767cf0ed8a5256","type":"text","conversion_output":true,"text":"important implications for the assessment and treatment of postoperative pain. We plan to compare","text_display":" important implications for the assessment and treatment of postoperative pain. We plan to compare","confidence":1,"confidence_rate":1},{"cnt":[[245,1989],[1957,1989],[1957,2039],[245,2039]],"region":{"top_left_x":244,"top_left_y":1989,"width":1714,"height":50},"line":38,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5194e1c6a3a3488f978ab7fedee7f47d","type":"text","conversion_output":true,"text":"patient reported and behavioral pain assessments in both non-delirious and delirious patients. \\({ }^{130}\\) (See","text_display":" patient reported and behavioral pain assessments in both non-delirious and delirious patients. \\({ }^{130}\\) (See","confidence":1,"confidence_rate":1},{"cnt":[[245,2037],[1021,2037],[1021,2082],[245,2082]],"region":{"top_left_x":244,"top_left_y":2036,"width":777,"height":46},"line":39,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d3d1926f0e0d477da756a77665cf4c5b","type":"text","conversion_output":true,"text":"Appendices for pain assessment instruments)","text_display":" Appendices for pain assessment instruments)","confidence":1,"confidence_rate":1}],"page_height":2125,"page_width":2750,"languages_detected":[]},{"image_id":"bc98861d-d1f8-4ebc-bb24-2b4b6a198b83-27","page":27,"lines":[{"cnt":[[245,159],[1923,159],[1923,204],[245,204]],"region":{"top_left_x":244,"top_left_y":158,"width":1679,"height":47},"line":1,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"17ed2bc4f4c340ecb9648a500aab61e0","type":"text","conversion_output":true,"text":"(conducted with the CAM-ICU) will be collected when these are available. Comparison will be made","text_display":"\n(conducted with the CAM-ICU) will be collected when these are available. Comparison will be made","confidence":1,"confidence_rate":1},{"cnt":[[245,202],[1835,202],[1835,247],[245,247]],"region":{"top_left_x":244,"top_left_y":201,"width":1591,"height":47},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"0bfe390cec754c78bbcc6ea0a08d17b4","type":"text","conversion_output":true,"text":"between these routine clinical assessments and the assessments made by the research team.","text_display":" between these routine clinical assessments and the assessments made by the research team.","confidence":1,"confidence_rate":1},{"cnt":[[183,288],[1141,288],[1141,333],[183,333]],"region":{"top_left_x":182,"top_left_y":287,"width":959,"height":47},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"40e497d553a24980b04d30886cd3a853","type":"text","conversion_output":true,"text":"h) Association Between Delirium and Patient Outcomes","text_display":"\nh) Association Between Delirium and Patient Outcomes","confidence":1,"confidence_rate":1},{"cnt":[[245,333],[1893,333],[1893,380],[245,380]],"region":{"top_left_x":244,"top_left_y":333,"width":1649,"height":48},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"16fcb2d299924193b80991231dcd3060","type":"text","conversion_output":true,"text":"The ENGAGES study will be evaluate the association between postoperative delirium and patient","text_display":"\n\nThe ENGAGES study will be evaluate the association between postoperative delirium and patient","confidence":1,"confidence_rate":1},{"cnt":[[245,378],[1768,378],[1768,423],[245,423]],"region":{"top_left_x":244,"top_left_y":378,"width":1525,"height":46},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"a92fac8400674d8d8bbcc336ce467e63","type":"text","conversion_output":true,"text":"reported outcome metrics, including quality of life and falls, up to one year postoperatively.","text_display":" reported outcome metrics, including quality of life and falls, up to one year postoperatively.","confidence":1,"confidence_rate":1},{"cnt":[[180,464],[1549,464],[1549,509],[180,509]],"region":{"top_left_x":180,"top_left_y":464,"width":1370,"height":46},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1ba652c24c5640c3b2754555f6f31a58","type":"text","conversion_output":true,"text":"i) Postoperative outcomes hypothesized to be associated with anesthetic depth","text_display":"\ni) Postoperative outcomes hypothesized to be associated with anesthetic depth","confidence":1,"confidence_rate":1},{"cnt":[[245,507],[1974,507],[1974,552],[245,552]],"region":{"top_left_x":244,"top_left_y":507,"width":1731,"height":46},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"85e2a08a36b3418ea950ffdd2a1500d8","type":"text","conversion_output":true,"text":"It is likely that patients randomized to the EEG-guided protocol will be exposed to lower concentrations","text_display":"\n\nIt is likely that patients randomized to the EEG-guided protocol will be exposed to lower concentrations","confidence":1,"confidence_rate":1},{"cnt":[[245,552],[1813,552],[1813,595],[245,595]],"region":{"top_left_x":244,"top_left_y":552,"width":1570,"height":44},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"298d2afc4a1e4f869507c7f466e5a137","type":"text","conversion_output":true,"text":"of anesthetic agents, and on average will not be as deeply anesthetized. There is an ongoing","text_display":" of anesthetic agents, and on average will not be as deeply anesthetized. There is an ongoing","confidence":1,"confidence_rate":1},{"cnt":[[245,593],[1957,593],[1957,640],[245,640]],"region":{"top_left_x":244,"top_left_y":592,"width":1714,"height":49},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"51d0eac0fbbc4f4daa84e989f4fb46f5","type":"text","conversion_output":true,"text":"randomized, clinical trial investigating the effects of depth of anesthesia on a range of outcomes \\({ }^{101,102}\\),","text_display":" randomized, clinical trial investigating the effects of depth of anesthesia on a range of outcomes \\({ }^{101,102}\\),","confidence":0.99951171875,"confidence_rate":0.9999960292721264},{"cnt":[[245,640],[1987,640],[1987,685],[245,685]],"region":{"top_left_x":244,"top_left_y":640,"width":1744,"height":46},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"326b7e49dc3448c79f3ed71def2a10ae","type":"text","conversion_output":true,"text":"including death, myocardial infarction, cardiac arrest, pulmonary embolus, stroke, surgical site infection,","text_display":" including death, myocardial infarction, cardiac arrest, pulmonary embolus, stroke, surgical site infection,","confidence":1,"confidence_rate":1},{"cnt":[[245,683],[1858,683],[1858,728],[245,728]],"region":{"top_left_x":244,"top_left_y":683,"width":1615,"height":46},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"e245dc8f3c134a6d8e7451c72c7ab0f1","type":"text","conversion_output":true,"text":"ICU length of stay, hospital length of stay, intraoperative awareness, persistent pain and cancer","text_display":" ICU length of stay, hospital length of stay, intraoperative awareness, persistent pain and cancer","confidence":1,"confidence_rate":1},{"cnt":[[245,726],[1936,726],[1936,771],[245,771]],"region":{"top_left_x":244,"top_left_y":726,"width":1692,"height":46},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ed7c7ebfea1442ffa9c22381d92e3d63","type":"text","conversion_output":true,"text":"recurrence. Many of these outcomes are tracked with the SATISFY-SOS study, and will therefore be","text_display":" recurrence. Many of these outcomes are tracked with the SATISFY-SOS study, and will therefore be","confidence":1,"confidence_rate":1},{"cnt":[[245,769],[1149,769],[1149,814],[245,814]],"region":{"top_left_x":244,"top_left_y":769,"width":906,"height":46},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"31146873f3874ef28af9c85320ec872b","type":"text","conversion_output":true,"text":"reported for patients enrolled in the ENGAGES study.","text_display":" reported for patients enrolled in the ENGAGES study.","confidence":1,"confidence_rate":1},{"cnt":[[180,855],[703,855],[703,900],[180,900]],"region":{"top_left_x":180,"top_left_y":855,"width":523,"height":46},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b04f4002a28d48588ba21c1c0ea44748","type":"text","conversion_output":true,"text":"j) Delirium Prediction Models","text_display":"\nj) Delirium Prediction Models","confidence":1,"confidence_rate":1},{"cnt":[[245,902],[1962,902],[1962,947],[245,947]],"region":{"top_left_x":244,"top_left_y":902,"width":1718,"height":46},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2c9d4d0b1b5a4b8e86ba800128106ce0","type":"text","conversion_output":true,"text":"It is important to improve our understanding of factors that are associated with an increased incidence","text_display":"\n\nIt is important to improve our understanding of factors that are associated with an increased incidence","confidence":1,"confidence_rate":1},{"cnt":[[245,945],[1901,945],[1901,990],[245,990]],"region":{"top_left_x":244,"top_left_y":945,"width":1658,"height":46},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"659754d6f7f544b193422d012e507852","type":"text","conversion_output":true,"text":"of postoperative delirium or perhaps may even mediate an elevated risk for postoperative delirium.","text_display":" of postoperative delirium or perhaps may even mediate an elevated risk for postoperative delirium.","confidence":1,"confidence_rate":1},{"cnt":[[245,988],[1871,988],[1871,1033],[245,1033]],"region":{"top_left_x":244,"top_left_y":988,"width":1628,"height":46},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ea2f67b677414b43b7db03920baa5a56","type":"text","conversion_output":true,"text":"Previous studies have explored risk factors, usually using logistic regression models. \\({ }^{29,136-148}\\) In a","text_display":" Previous studies have explored risk factors, usually using logistic regression models. \\({ }^{29,136-148}\\) In a","confidence":0.9912188034504652,"confidence_rate":0.9999246184100763},{"cnt":[[245,1033],[1934,1033],[1934,1076],[245,1076]],"region":{"top_left_x":244,"top_left_y":1033,"width":1690,"height":44},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b429430d0dc84cecbcbfdfb6eb04e20a","type":"text","conversion_output":true,"text":"previous study we used a Bayesian exploratory approach with a stochastic search variable selection","text_display":" previous study we used a Bayesian exploratory approach with a stochastic search variable selection","confidence":1,"confidence_rate":1},{"cnt":[[245,1074],[1809,1074],[1809,1121],[245,1121]],"region":{"top_left_x":244,"top_left_y":1074,"width":1565,"height":48},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"62ea541d6b1248fb80673aa7ab8e14f0","type":"text","conversion_output":true,"text":"method. \\({ }^{29}\\) The ENGAGES study will rigorously assess a large number of surgical patients for","text_display":" method. \\({ }^{29}\\) The ENGAGES study will rigorously assess a large number of surgical patients for","confidence":1,"confidence_rate":1},{"cnt":[[245,1121],[1938,1121],[1938,1167],[245,1167]],"region":{"top_left_x":244,"top_left_y":1121,"width":1694,"height":46},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"7f98e5ec5c3c490ca848b9ed401ef25a","type":"text","conversion_output":true,"text":"postoperative delirium, and it will therefore lend itself to further exploration, refinement of risk models","text_display":" postoperative delirium, and it will therefore lend itself to further exploration, refinement of risk models","confidence":1,"confidence_rate":1},{"cnt":[[245,1164],[1979,1164],[1979,1210],[245,1210]],"region":{"top_left_x":244,"top_left_y":1164,"width":1735,"height":46},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"96c7c59ba005438c86a66f098f81669c","type":"text","conversion_output":true,"text":"and hypothesis generation. Based on results from previous studies, we will include specific variables in","text_display":" and hypothesis generation. Based on results from previous studies, we will include specific variables in","confidence":1,"confidence_rate":1},{"cnt":[[245,1207],[1888,1207],[1888,1253],[245,1253]],"region":{"top_left_x":244,"top_left_y":1207,"width":1645,"height":46},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5a9c75ae25324e319b0aedf79652de8e","type":"text","conversion_output":true,"text":"our analyses. Patient age, demographic, life style and comorbidity information will be assessed at","text_display":" our analyses. Patient age, demographic, life style and comorbidity information will be assessed at","confidence":1,"confidence_rate":1},{"cnt":[[245,1250],[1970,1250],[1970,1296],[245,1296]],"region":{"top_left_x":244,"top_left_y":1250,"width":1727,"height":46},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cacddcf436204b58a68523658c2c22f7","type":"text","conversion_output":true,"text":"baseline through a standardized interview in the CPAP clinic. Data on previously described risk factors","text_display":" baseline through a standardized interview in the CPAP clinic. Data on previously described risk factors","confidence":1,"confidence_rate":1},{"cnt":[[245,1293],[1835,1293],[1835,1338],[245,1338]],"region":{"top_left_x":244,"top_left_y":1293,"width":1591,"height":46},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"8ee9f609ffd24f5ba63a35174b582c96","type":"text","conversion_output":true,"text":"for postoperative delirium will be acquired including: history of postoperative delirium, modified","text_display":" for postoperative delirium will be acquired including: history of postoperative delirium, modified","confidence":1,"confidence_rate":1},{"cnt":[[245,1336],[1970,1336],[1970,1381],[245,1381]],"region":{"top_left_x":244,"top_left_y":1336,"width":1727,"height":46},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c66664a6d8b441fa81d76e80035d54c3","type":"text","conversion_output":true,"text":"Charlson Comorbidity Index, American Society of Anesthesiologists' Physical Status, functional status,","text_display":" Charlson Comorbidity Index, American Society of Anesthesiologists' Physical Status, functional status,","confidence":0.99755859375,"confidence_rate":0.9999771554820448},{"cnt":[[245,1381],[1983,1381],[1983,1427],[245,1427]],"region":{"top_left_x":244,"top_left_y":1381,"width":1740,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"19f64f7255e349cbbc735535651fdee4","type":"text","conversion_output":true,"text":"level of education, olfaction, baseline cognition, depression (using the PHQ-9 questionnaire), indices of","text_display":" level of education, olfaction, baseline cognition, depression (using the PHQ-9 questionnaire), indices 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