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Provide median, interquartile range, and range at each time point.","confidence":1,"confidence_rate":1},{"cnt":[[243,606],[864,606],[864,651],[243,651]],"region":{"top_left_x":242,"top_left_y":605,"width":622,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6d8ec0f4bc734aa2a34ad8226829ec62","type":"text","conversion_output":true,"text":"Analysis Plan: Generalized linear model","text_display":"\n\nAnalysis Plan: Generalized linear model","confidence":1,"confidence_rate":1},{"cnt":[[361,649],[943,649],[943,709],[361,709]],"region":{"top_left_x":360,"top_left_y":648,"width":584,"height":61},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9160f74c78964e4898b8ea36dbf2c3f6","type":"math","conversion_output":true,"text":"\\[\ny_{365}=\\beta_{0}+f\\left(y_{0}\\right)+\\beta_{1} x+ \\beta Z+\\varepsilon\n\\]","text_display":"\n\\[\ny_{365}=\\beta_{0}+f\\left(y_{0}\\right)+\\beta_{1} x+ \\beta Z+\\varepsilon\n\\]","confidence":0.99951171875,"confidence_rate":0.9999907849387211},{"cnt":[[305,705],[1869,705],[1869,752],[305,752]],"region":{"top_left_x":305,"top_left_y":704,"width":1565,"height":48},"line":9,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"716fcf08be614ec1acd12ca3026c9c42","type":"text","conversion_output":true,"text":"- In this equation, \\(y_{365}\\) is the quality of life (either VR-12 PCS or VR-12 MCS) at one year, and \\(y_{0}\\) is","text_display":"\n- In this equation, \\(y_{365}\\) is the quality of life (either VR-12 PCS or VR-12 MCS) at one year, and \\(y_{0}\\) is","confidence":0.99951171875,"confidence_rate":0.9999961543341811},{"cnt":[[370,752],[1835,752],[1835,801],[370,801]],"region":{"top_left_x":369,"top_left_y":751,"width":1466,"height":51},"line":10,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b282d01197ee4c939536fbcd20544a7a","type":"text","conversion_output":true,"text":"the quality of life metric at baseline. \\(x\\) is the EEG guidance intervention ( \\(x =0\\) for control or \\(x =1\\)","text_display":" the quality of life metric at baseline. \\(x\\) is the EEG guidance intervention ( \\(x =0\\) for control or \\(x =1\\)","confidence":0.85986328125,"confidence_rate":0.9986879755649205},{"cnt":[[370,804],[1583,804],[1583,851],[370,851]],"region":{"top_left_x":369,"top_left_y":803,"width":1215,"height":48},"line":11,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"59ce5e3f079f4f1c8f2101231b26b351","type":"text","conversion_output":true,"text":"for intervention). \\(Z\\) is a vector of additional variables for which we will adjust.","text_display":" for intervention). \\(Z\\) is a vector of additional variables for which we will adjust.","confidence":0.9931697845458984,"confidence_rate":0.9999238512534984},{"cnt":[[305,855],[1863,855],[1863,904],[305,904]],"region":{"top_left_x":305,"top_left_y":855,"width":1558,"height":50},"line":12,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"e209f7fe0b514bae8de0625242840d4d","type":"text","conversion_output":true,"text":"- \\(f\\left(y_{0}\\right)\\) is a potentially nonlinear function describing the relationship between baseline quality of","text_display":"\n- \\(f\\left(y_{0}\\right)\\) is a potentially nonlinear function describing the relationship between baseline quality of","confidence":0.9679069519042969,"confidence_rate":0.9997139065431404},{"cnt":[[370,904],[1579,904],[1579,952],[370,952]],"region":{"top_left_x":369,"top_left_y":904,"width":1211,"height":48},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8515dc3574d440918bb18522c9fc3668","type":"text","conversion_output":true,"text":"life and quality of life at one year. This function will be modeled using splines.","text_display":" life and quality of life at one year. This function will be modeled using splines.","confidence":1,"confidence_rate":1},{"cnt":[[305,954],[1807,954],[1807,1003],[305,1003]],"region":{"top_left_x":305,"top_left_y":953,"width":1502,"height":51},"line":14,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"509f0ef7f58a4a5795264704fac39c06","type":"text","conversion_output":true,"text":"- Will perform unadjusted ( \\(Z =\\) null) and adjusted ( Z not null) analyses. Will adjust for age, sex,","text_display":"\n- Will perform unadjusted ( \\(Z =\\) null) and adjusted ( Z not null) analyses. Will adjust for age, sex,","confidence":0.8158497100953355,"confidence_rate":0.998247011387823},{"cnt":[[367,1005],[1764,1005],[1764,1055],[367,1055]],"region":{"top_left_x":367,"top_left_y":1005,"width":1397,"height":50},"line":15,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a9eeb52d6088443985f92e3ed861b767","type":"text","conversion_output":true,"text":"American Society of Anesthesiologists (ASA) physical status classification (1-2 vs 3 vs 4-5),","text_display":" American Society of Anesthesiologists (ASA) physical status classification (1-2 vs 3 vs 4-5),","confidence":0.7722227680496871,"confidence_rate":0.997444042225504},{"cnt":[[370,1057],[1807,1057],[1807,1102],[370,1102]],"region":{"top_left_x":369,"top_left_y":1057,"width":1438,"height":46},"line":16,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1008b6e342ae407a82f95fa623d34c39","type":"text","conversion_output":true,"text":"number of comorbid conditions, baseline poor functional capacity (<4 METS), history of falls","text_display":" number of comorbid conditions, baseline poor functional capacity (<4 METS), history of falls","confidence":1,"confidence_rate":1},{"cnt":[[370,1104],[1863,1104],[1863,1154],[370,1154]],"region":{"top_left_x":369,"top_left_y":1104,"width":1494,"height":50},"line":17,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f12cc0a3da49452994282c4aa635570e","type":"text","conversion_output":true,"text":"(yes/no within previous 6 months), evidence of abnormal cognition (preoperative Short Blessed","text_display":" (yes/no within previous 6 months), evidence of abnormal cognition (preoperative Short Blessed","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[370,1156],[1861,1156],[1861,1205],[370,1205]],"region":{"top_left_x":369,"top_left_y":1155,"width":1492,"height":51},"line":18,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"6dfecff0d16642fe9e517bc605615c6d","type":"text","conversion_output":true,"text":"Test score \\(>4\\) ), surgery type (cardiac versus non-cardiac), length of anesthesia (Anesthesia Stop","text_display":" Test score \\(>4\\) ), surgery type (cardiac versus non-cardiac), length of anesthesia (Anesthesia Stop","confidence":0.9661037921905518,"confidence_rate":0.9996716348264139},{"cnt":[[370,1207],[672,1207],[672,1253],[370,1253]],"region":{"top_left_x":369,"top_left_y":1207,"width":304,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"46094f1fba3042aba113b2ca8379d4cc","type":"text","conversion_output":true,"text":"- Anesthesia Start)","text_display":" - Anesthesia Start)","confidence":0.98095703125,"confidence_rate":0.9991992115796358},{"cnt":[[432,1257],[1798,1257],[1798,1304],[432,1304]],"region":{"top_left_x":431,"top_left_y":1256,"width":1368,"height":49},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"bd7e502a76cc4a5b9551c08a203cbdaa","type":"text","conversion_output":true,"text":"- Multiple imputation may be performed to address missing values of these variables","text_display":"\n- Multiple imputation may be performed to address missing values of these variables","confidence":1,"confidence_rate":1},{"cnt":[[305,1308],[1747,1308],[1747,1356],[305,1356]],"region":{"top_left_x":305,"top_left_y":1308,"width":1442,"height":48},"line":21,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"9a2c0bcc24894630af2aed60fc459443","type":"text","conversion_output":true,"text":"- Any patient with missing quality of life either at baseline or at one year will be excluded.","text_display":"\n- Any patient with missing quality of life either at baseline or at one year will be excluded.","confidence":1,"confidence_rate":1},{"cnt":[[305,1358],[1824,1358],[1824,1405],[305,1405]],"region":{"top_left_x":305,"top_left_y":1357,"width":1520,"height":49},"line":22,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"5e9db84fa2eb4f79a37ad4afc5477e42","type":"text","conversion_output":true,"text":"- \\(H_{0}: \\beta_{1}=0\\) (The null hypothesis is that the EEG guidance intervention has no association with","text_display":"\n- \\(H_{0}: \\beta_{1}=0\\) (The null hypothesis is that the EEG guidance intervention has no association with","confidence":0.8175086975097656,"confidence_rate":0.9982340721666416},{"cnt":[[370,1405],[827,1405],[827,1454],[370,1454]],"region":{"top_left_x":369,"top_left_y":1405,"width":459,"height":50},"line":23,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7588eb6eec4042c0ad6cf652469e0287","type":"text","conversion_output":true,"text":"postoperative quality of life.)","text_display":" postoperative quality of life.)","confidence":1,"confidence_rate":1},{"cnt":[[236,1504],[694,1504],[694,1562],[236,1562]],"region":{"top_left_x":236,"top_left_y":1503,"width":458,"height":59},"line":24,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b5c804334de047c096ad30643abbd00c","type":"section_header","conversion_output":false,"children_ids":["0fa03a2b60b443ecb12c6dbb2d9a21af"],"text":"","text_display":""},{"cnt":[[245,1508],[690,1508],[690,1553],[245,1553]],"region":{"top_left_x":244,"top_left_y":1508,"width":446,"height":46},"line":25,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0fa03a2b60b443ecb12c6dbb2d9a21af","type":"text","conversion_output":true,"parent_id":"b5c804334de047c096ad30643abbd00c","text":"Planned Sensitivity Analyses","text_display":"\n\n\\section*{Planned Sensitivity Analyses}","confidence":1,"confidence_rate":1},{"cnt":[[305,1560],[1033,1560],[1033,1605],[305,1605]],"region":{"top_left_x":305,"top_left_y":1559,"width":729,"height":46},"line":26,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ba0d011378a04b65bced4af5ac2d04ee","type":"text","conversion_output":true,"text":"1. Best-Likely-Case Scenario for Missing Data","text_display":"\n1. Best-Likely-Case Scenario for Missing Data","confidence":1,"confidence_rate":1},{"cnt":[[434,1611],[1837,1611],[1837,1656],[434,1656]],"region":{"top_left_x":433,"top_left_y":1611,"width":1404,"height":46},"line":27,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"95df061aec8e4731b4f204dfc03163eb","type":"text","conversion_output":true,"text":"- For patients missing baseline quality of life, set the baseline quality of life equal to the","text_display":"\n- For patients missing baseline quality of life, set the baseline quality of life equal to the","confidence":1,"confidence_rate":1},{"cnt":[[494,1659],[1815,1659],[1815,1708],[494,1708]],"region":{"top_left_x":494,"top_left_y":1658,"width":1322,"height":51},"line":28,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c577c4ff65c84c2fbe70719e3988313f","type":"text","conversion_output":true,"text":"mean baseline value for the appropriate stratum of the population. Population to be","text_display":" mean baseline value for the appropriate stratum of the population. Population to be","confidence":1,"confidence_rate":1},{"cnt":[[494,1710],[1783,1710],[1783,1755],[494,1755]],"region":{"top_left_x":494,"top_left_y":1710,"width":1290,"height":46},"line":29,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8498759f91864f9e98a74f75328dd2cc","type":"text","conversion_output":true,"text":"stratified based on type of surgery (cardiac versus non-cardiac) and history of falls.","text_display":" stratified based on type of surgery (cardiac versus non-cardiac) and history of falls.","confidence":1,"confidence_rate":1},{"cnt":[[434,1762],[1858,1762],[1858,1807],[434,1807]],"region":{"top_left_x":433,"top_left_y":1761,"width":1426,"height":46},"line":30,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c74ebe9122b34c908fea173b3fb8a166","type":"text","conversion_output":true,"text":"- For patients in the intervention group missing one-year quality of life, set the quality of","text_display":"\n- For patients in the intervention group missing one-year quality of life, set the quality of","confidence":1,"confidence_rate":1},{"cnt":[[494,1809],[1755,1809],[1755,1858],[494,1858]],"region":{"top_left_x":494,"top_left_y":1808,"width":1262,"height":51},"line":31,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"0a8aa76bf66d45459b5a246c7346c913","type":"text","conversion_output":true,"text":"life value equal to the maximum postoperative quality of life within the patient's","text_display":" life value equal to the maximum postoperative quality of life within the patient's","confidence":1,"confidence_rate":1},{"cnt":[[494,1861],[1454,1861],[1454,1910],[494,1910]],"region":{"top_left_x":494,"top_left_y":1860,"width":961,"height":50},"line":32,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"163a0a9bcdf64bb69359b6476959ad94","type":"text","conversion_output":true,"text":"stratum (still stratified by type of surgery and history of falls).","text_display":" stratum (still stratified by type of surgery and history of falls).","confidence":1,"confidence_rate":1},{"cnt":[[434,1912],[1830,1912],[1830,1957],[434,1957]],"region":{"top_left_x":433,"top_left_y":1912,"width":1398,"height":46},"line":33,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"d950cebe7050444a8d6a6d7b82af26fb","type":"text","conversion_output":true,"text":"- For patients in the control group missing one-year quality of life, set the quality of life","text_display":"\n- For patients in the control group missing one-year quality of life, set the quality of life","confidence":1,"confidence_rate":1},{"cnt":[[494,1962],[1824,1962],[1824,2009],[494,2009]],"region":{"top_left_x":494,"top_left_y":1961,"width":1331,"height":48},"line":34,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"8bb7e607239a4963a1606f0c6e9d5fe3","type":"text","conversion_output":true,"text":"value equal to the minimum postoperative quality of life within the patient's stratum","text_display":" value equal to the minimum postoperative quality of life within the patient's stratum","confidence":1,"confidence_rate":1},{"cnt":[[494,2011],[1326,2011],[1326,2060],[494,2060]],"region":{"top_left_x":494,"top_left_y":2010,"width":832,"height":51},"line":35,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"f7e3b2258c8343ed9368c65ae8041fad","type":"text","conversion_output":true,"text":"(still stratified by type of surgery and history of falls).","text_display":" (still stratified by type of surgery and history of falls).","confidence":1,"confidence_rate":1},{"cnt":[[434,2062],[1287,2062],[1287,2108],[434,2108]],"region":{"top_left_x":433,"top_left_y":2062,"width":854,"height":46},"line":36,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"146137a45c9d4742b8511c90dabdc6a0","type":"text","conversion_output":true,"text":"- Patients who die before one year will be excluded.","text_display":"\n- Patients who die before one year will be excluded.","confidence":1,"confidence_rate":1},{"cnt":[[305,2110],[1061,2110],[1061,2159],[305,2159]],"region":{"top_left_x":305,"top_left_y":2109,"width":757,"height":51},"line":37,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"fd6c60e0b8e0463e9d082015a27b12aa","type":"text","conversion_output":true,"text":"2. Worst-Likely-Case Scenario for Missing Data","text_display":"\n2. Worst-Likely-Case Scenario for Missing Data","confidence":0.9990236759185791,"confidence_rate":0.9999808472227066},{"cnt":[[434,2161],[1835,2161],[1835,2211],[434,2211]],"region":{"top_left_x":433,"top_left_y":2161,"width":1402,"height":50},"line":38,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"915be695439742c18e623311386e7be9","type":"text","conversion_output":true,"text":"- For patients missing baseline quality of life, set the baseline quality of life equal to the","text_display":"\n- For patients missing baseline quality of life, set the baseline quality of life equal to the","confidence":1,"confidence_rate":1},{"cnt":[[494,2213],[1815,2213],[1815,2260],[494,2260]],"region":{"top_left_x":494,"top_left_y":2212,"width":1322,"height":49},"line":39,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"c7947374d22c4c79b3f545c4d705aab6","type":"text","conversion_output":true,"text":"mean baseline value for the appropriate stratum of the population. Population to be","text_display":" mean baseline value for the appropriate stratum of the population. 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These changes were made to reduce the number of degrees of freedom","text_display":" been dropped. 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Deceased Patients","text_display":"\n1. Deceased Patients","confidence":1,"confidence_rate":1},{"cnt":[[434,1160],[1373,1160],[1373,1205],[434,1205]],"region":{"top_left_x":433,"top_left_y":1160,"width":940,"height":46},"line":19,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"2ed131bf96864a4f90ee38b32b5b1eac","type":"text","conversion_output":true,"text":"- Assume all patients who die within one year have fallen.","text_display":"\n- Assume all patients who die within one year have fallen.","confidence":1,"confidence_rate":1},{"cnt":[[305,1212],[935,1212],[935,1253],[305,1253]],"region":{"top_left_x":305,"top_left_y":1211,"width":630,"height":42},"line":20,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"1aba144129f844ee9735c0f0d932f79d","type":"text","conversion_output":true,"text":"2. Best-Case Scenario for Missing Data","text_display":"\n2. 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Is duration of intraoperative EEG suppression (minutes with suppression ratio \\(>1 \\%\\) ) associated","text_display":"\n1. Is duration of intraoperative EEG suppression (minutes with suppression ratio \\(>1 \\%\\) ) associated","confidence":0.9951171875,"confidence_rate":0.9999533842067715},{"cnt":[[370,2316],[617,2316],[617,2361],[370,2361]],"region":{"top_left_x":369,"top_left_y":2316,"width":248,"height":46},"line":41,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b30c0227396a4a97a21de5adab6315d4","type":"text","conversion_output":true,"text":"with mortality?","text_display":" with mortality?","confidence":1,"confidence_rate":1},{"cnt":[[432,2368],[1755,2368],[1755,2413],[432,2413]],"region":{"top_left_x":431,"top_left_y":2367,"width":1325,"height":46},"line":42,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"7bc7dcd0fde8475dba861c71de6ef272","type":"text","conversion_output":true,"text":"a. 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Is duration of intraoperative EEG suppression (minutes with suppression ratio \\(>1 \\%\\) ) associated","text_display":"\n3. Is duration of intraoperative EEG suppression (minutes with suppression ratio \\(>1 \\%\\) ) associated","confidence":0.99365234375,"confidence_rate":0.9999393552838918},{"cnt":[[370,507],[812,507],[812,552],[370,552]],"region":{"top_left_x":369,"top_left_y":507,"width":444,"height":46},"line":6,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"b9f712ea640a4f5ab0fd06f9a8216d1f","type":"text","conversion_output":true,"text":"with more falls at one year?","text_display":" with more falls at one year?","confidence":1,"confidence_rate":1},{"cnt":[[430,554],[1545,554],[1545,604],[430,604]],"region":{"top_left_x":429,"top_left_y":554,"width":1116,"height":50},"line":7,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"a08edf7ff5e649b69471e8f342b71cb9","type":"text","conversion_output":true,"text":"a. 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Is duration of intraoperative BIS < 40 associated with worse quality of life at one year?","text_display":"\n5. Is duration of intraoperative BIS < 40 associated with worse quality of life at one year?","confidence":0.9824728588656058,"confidence_rate":0.9998231900308797},{"cnt":[[430,855],[1450,855],[1450,904],[430,904]],"region":{"top_left_x":429,"top_left_y":855,"width":1022,"height":50},"line":13,"column":0,"font_size":28,"is_printed":true,"is_handwritten":false,"id":"ad3f96588feb4994bd2cdffdf3da906f","type":"text","conversion_output":true,"text":"a. Generalized linear model, same structure as in hypothesis \\#2","text_display":"\na. 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