Prompt: Has the USPSTF recommendation for mammography screening changed recently?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (April 30, 2024): screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

What changed: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40 (previous version: 2016).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Quick question: I'm 76 with no family history of cancer and no symptoms. Is it time for me to get screened for colon cancer?

Response:
At 76, screening is a Grade C recommendation — meaning it should be offered selectively rather than routinely. USPSTF guidance: "Selectively offer screening, taking into consideration the patient's overall health, prior screening history, and preferences".

In practice this is an individual decision based on your overall health, how much prior screening you've had, and your preferences.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What is investment banking?

Response:
Investment banking pertains to certain activities of a financial services company or a corporate division that consist in advisory-based financial transactions on behalf of individuals, corporations, and governments. Traditionally associated with corporate finance, such a bank might assist in raising financial capital by underwriting or acting as the client's agent in the issuance of debt or equity securities. An investment bank may also assist companies involved in mergers and acquisitions (M&A) and provide ancillary services such as market making, trading of derivatives and equity securities, FICC services (fixed income instruments, currencies, and commodities) or research (macroeconomic, credit or equity research). Most investment banks maintain prime brokerage and asset management departments in conjunction with their investment research businesses. As an industry, it is broken up into the Bulge Bracket (upper tier), Middle Market (mid-level businesses), and boutique market (specialized businesses).

Unlike commercial banks and retail banks, investment banks do not take deposits.


Prompt: Why do people move to California?

Response: There are many reasons why people may decide to move to California. California has very mild winters compared to many other parts of the United States. There are many jobs in technology, agriculture, finance, and film as well as other industries. California also has a very high number of universities for those looking to pursue higher education.


Prompt: Quick question: I'm 28 and my brother was diagnosed with colorectal cancer at 56. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 56 − 10 = 46 — and since 46 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 46, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My uncle just turned 78, I have a 18 pack-year smoking history and quit 15 years ago. Do I meet the criteria for low-dose CT lung screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: a 18 pack-year history is below the 20 pack-year threshold.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: How do you gain muscle?

Response: Gaining muscle mass requires proper exercise and a good diet. A good diet is important to give the body the nutrient it needs in order to sustain muscle growth. On the flip side, properly stressing the muscles will stimulate them to grow. This requires a variance of different exercises to work the muscle group. Otherwise, the muscle will build resistance to an often repeated exercise, and growth for that muscle will plateau.


Prompt: I'm 46 years old. What's the screening test for testicular cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for testicular cancer in adolescent or adult men."

This applies to adolescent and adult men. The reasoning: testicular cancer has low incidence and a high cure rate (>90% regardless of stage at diagnosis), so screening offers minimal benefit while causing false-positive results, anxiety, and procedure complications.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for testicular cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Testicular Cancer: Screening, 2011 (Grade D).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm asking for my wife, who is 81, I have a 25 pack-year smoking history and quit 16 years ago. Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 81 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. Also: having quit 16 years ago exceeds the 15-year since-quitting cutoff. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My aunt just turned 88 with no family history of cancer and no symptoms. Do I need to start colon cancer screening yet?

Response:
Routine screening is generally not recommended past age 85. USPSTF guidance covers adults up to 85; beyond that, the decision depends on overall health and life expectancy and should be made with a clinician.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 55 with no family history of cancer and no symptoms — Do I need to start colon cancer screening yet?

Response:
Yes — at 55 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: What is the meaning of life?

Response: Although it is a deep question that has challenged philosophers for all time, Douglas Adams in his book "The Hitchhicker's Guide to the Universe" humorously states that the answer is "42".


Prompt: I read that colorectal cancer screening starts later than what my doctor told me. What's the current guidance?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (May 18, 2021): screening begins at age 45 (Grade B for 45-49, Grade A for 50-75).

What changed: starting age lowered from 50 to 45 (previous version: 2016).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: hey do I need a mammogram??

Response:
Two things determine this: your age, and whether you carry a BRCA mutation or have a strong family history of breast or ovarian cancer. At average risk, screening is recommended starting at 40, every 2 years. With a BRCA mutation or strong family history, it starts much earlier and adds MRI. What's your age, and is there a relevant family or genetic history?

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
Extract the basic universal competition sections of the triathlon in order, and explain each section.

While specific rules for triathlon can vary depending on the governing body (e.g. World Triathlon, USA Triathlon), as well as for an individual race venue, there are some basic universal rules. Traditionally, triathlon is an individual sport and each athlete is competing against the course and the clock for the best time. As such, athletes are not allowed to receive assistance from anyone else outside the race, with the exception of race-sanctioned aid volunteers who distribute food and water on the course.

Transition area (bicycles) of Hamburg Triathlon, 2002
Triathlons are timed in five sequential sections:

from the start of the swim to the beginning of the first transition (swim time);
from the beginning of the first transition to the end of the first transition (T1 time);
from the start of the cycling to the end of the cycling leg (cycling time);
from the beginning of the second transition to the end of the second transition (T2 time);
finally from the start of the run to the end of the run, at which time the triathlon is completed.
Results are usually posted on official websites and will show for each triathlete his/her swim time; cycle time (with transitions included); run time; and total time. Some races also post transition times separately.

Other rules of triathlon vary from race to race and generally involve descriptions of allowable equipment (for example, wetsuits are allowed in USAT events in the swimming stage of some races when the water temperature is below 25.6 °C (78.1 °F)), and prohibitions against interference between athletes. Additionally, the use of flippers or other swim propulsion and flotation aids are illegal in triathlon and can result in disqualification.

One rule involving the cycle leg is that the competitor's helmet must be donned before the competitor mounts (or even takes possession of, in certain jurisdictions) the bike, and it must remain on until the competitor has dismounted; the competitor may not be required to wear the helmet when not on the bicycle (e.g. while repairing a mechanical problem). Failure to comply with this rule will result in disqualification. Additionally, while on the bike course, all bicycles shall be propelled only by human force and human power. Other than pushing a bicycle, any propulsive action brought on by use of the hands is prohibited. Should a competitor's bike malfunction they can proceed with the race as long as they are doing so with their bicycle in tow. There are also strict rules regarding the 'bike mount' line. Competitors may not begin riding their bicycle out of transition until they are over a clearly marked line. Mounting the bike prior to this may incur a penalty (example: a 15-second time penalty at the London 2012 Olympics was imposed on Jonathan Brownlee, a competitor from Great Britain, for mounting his bike too early.)

Other time penalties can be incurred during the race for, among other things, drafting on the bike in a non-drafting race, improper passing, littering on course, and unsportsmanlike conduct.

Response:
Triathlons are timed in five sequential sections.
From the start of the swim to the beginning of the first transition (swim time). The use of flippers or other swim propulsion and flotation aids are illegal.
From the beginning of the first transition to the end of the first transition (T1 time).
From the start of the cycling to the end of the cycling leg (cycling time). The competitor's helmet must be donned before the competitor mounts the bike, and it must remain on until the competitor has dismounted.
From the beginning of the second transition to the end of the second transition (T2 time)
Finally from the start of the run to the end of the run, at which time the triathlon is completed.


Prompt: Tell me whether these are TV shows or movies

Response: Game of Thrones, Titanic, Smallville, Ozark, Peaky Blinders


Prompt: do I need a mammogram?

Response:
Two things determine this: your age, and whether you carry a BRCA mutation or have a strong family history of breast or ovarian cancer. At average risk, screening is recommended starting at 40, every 2 years. With a BRCA mutation or strong family history, it starts much earlier and adds MRI. What's your age, and is there a relevant family or genetic history?

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt:
Tell me about the 2017 Southeastern Conference football season

The 2017 Southeastern Conference football season was the 85th season of SEC football and took place during the 2017 NCAA Division I FBS football season. The season began on August 31 and will end with the 2017 SEC Championship Game on December 2. The SEC is a Power Five conference under the College Football Playoff format along with the Atlantic Coast Conference, the Big 12 Conference, the Big Ten Conference, and the Pac–12 Conference. For the 2017 season, the SEC has 14 teams divided into two divisions of seven each, named East and West.

Response: The 2017 Southeastern Conference football season was the 85th season of SEC football and took place during the 2017 NCAA Division I FBS football season. The season began on August 31 and will end with the 2017 SEC Championship Game on December 2.


Prompt: I'm 67 with a 22 pack-year smoking history (quit 6 years ago) and a parent diagnosed with colorectal cancer at 62 — What cancer screenings should I be getting?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** Yes — you meet criteria. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Start at age 40 — that's the earlier of age 40 or 62−10=52, with colonoscopy every 5 years rather than every 10 years. At 67 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Quick question: I'm 57 and I've had change in bowel habits for 5 weeks. Should I get this checked?

Response:
Yes — get this evaluated. Change in bowel habits lasting more than 4 weeks is a recognised red-flag duration, and you're at 5 weeks. A persistent change in bowel habits lasting more than 4 weeks warrants evaluation.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 80 years old, I have a 40 pack-year smoking history and quit 14 years ago. Do I meet the criteria for low-dose CT lung screening?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 80 falls within 50-80, your 40 pack-year history meets the 20 pack-year minimum, and you quit 14 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 81, I smoke and have about a 30 pack-year history. Am I eligible for the annual lung screening scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 81 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm a 22-year-old and I recently tested positive for a pathogenic BRCA2 variant. Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA2 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 22, you would begin MRI surveillance in 3 years.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
How long after the release of the album “Abbey Road” did The Beatles break up?

By early 1964, the Beatles were international stars and had achieved unprecedented levels of critical and commercial success. They became a leading force in Britain's cultural resurgence, ushering in the British Invasion of the United States pop market, and soon made their film debut with A Hard Day's Night (1964). A growing desire to refine their studio efforts, coupled with the untenable nature of their concert tours, led to the band's retirement from live performances in 1966. At this time, they produced records of greater sophistication, including the albums Rubber Soul (1965), Revolver (1966) and Sgt. Pepper's Lonely Hearts Club Band (1967), and enjoyed further commercial success with The Beatles (also known as "the White Album", 1968) and Abbey Road (1969). The success of these records heralded the album era, as albums became the dominant form of record consumption over singles; they also increased public interest in psychedelic drugs and Eastern spirituality, and furthered advancements in electronic music, album art and music videos. In 1968, they founded Apple Corps, a multi-armed multimedia corporation that continues to oversee projects related to the band's legacy. After the group's break-up in 1970, all principal former members enjoyed success as solo artists and some partial reunions have occurred. Lennon was murdered in 1980 and Harrison died of lung cancer in 2001. McCartney and Starr remain musically active.

Response: One year after releasing Abbey Road (1969), the Beatles broke up (1970)


Prompt:
What conference does the Spokane Braves belong to?

The Spokane Braves are a Junior "B" Ice Hockey team based in Spokane, Washington, United States. They are members of the Neil Murdoch Division of the Kootenay Conference of the Kootenay International Junior Hockey League (KIJHL). They play their home games at Eagles Ice-A-Rena. The Braves are the only team in the KIJHL to play in the United States. They were forced to go on hiatus at the beginning of the 20/21 season due to the US/Canada border closure.

Response: The Spokane Braves are members of the Kootenay Conference of the Kootenay International Junior Hockey League (KIJHL).


Prompt: My aunt just turned 58 with no family history of breast cancer. Should I be getting mammograms?

Response:
Yes — at 58 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Why is Santa Cruz, California a great place to live?

Response: Santa Cruz, California has one of the best climates in the continental U.S. – being close to the Pacific Ocean, temperatures stay warmer in the winters and cooler in the summers, but without the dreaded fog that nearby cities like San Francisco or Monterey experience. The small city is world-famous for surfing, and the relaxed vibe that comes with it. Natural beauty is abundant, with the mountains and beach only a few miles apart.


Prompt: I'm 80 years old with no family history of breast cancer. Am I due for a mammogram?

Response:
Past age 74, USPSTF gives a Grade I — meaning "the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older". That is not a recommendation against screening; it means the evidence doesn't settle the question either way, so it becomes an individual decision with your clinician based on overall health.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What are common swimming strokes?

Response: The most common swimming strokes include the four strokes used in competition: freestyle (sometimes referred to as "the crawl"), breast stroke, back stroke and butterfly. In addition, some people swim using a side stroke or a doggy paddle (which looks a lot like the stroke dogs use when swimming).


Prompt: I'm 44 years old with no family history of cancer and no symptoms. Is it time for me to get screened for colon cancer?

Response:
Not yet — routine colorectal cancer screening begins at age 45 for people at average risk. At 44, you are 1 year away.

Two important caveats. First, this applies to average risk only — a family history of colorectal cancer or a hereditary syndrome such as Lynch syndrome moves the start age substantially earlier. Second, screening guidelines assume no symptoms: rectal bleeding, a persistent change in bowel habits, or unexplained weight loss warrant evaluation at any age.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Why did the Seattle Supersonics leave Seattle?

Response: In 2006 the owner of the team, Howard Schultz, sold the team Clay Bennett. Clay Bennett originally agreed to keep the team in Seattle, however, he then told the city that if a new arena was not built using public funds that he would move the team. Ultimately, public funding for the arena fell through and the team was moved to Oklahoma. The team is now known at the Oklahoma City Thunder. The relocation of the team was very controversial as local news organizations and fans believe that Clay Bennett's intention was to remove the team from Seattle and did not provide reasonable terms for a renovation of the basketball arena.


Prompt:
What is CBT?

Technological advances also renewed interest in mental states and mental representations. English neuroscientist Charles Sherrington and Canadian psychologist Donald O. Hebb used experimental methods to link psychological phenomena to the structure and function of the brain. The rise of computer science, cybernetics, and artificial intelligence underlined the value of comparing information processing in humans and machines.

A popular and representative topic in this area is cognitive bias, or irrational thought. Psychologists (and economists) have classified and described a sizeable catalogue of biases which recur frequently in human thought. The availability heuristic, for example, is the tendency to overestimate the importance of something which happens to come readily to mind.

Elements of behaviorism and cognitive psychology were synthesized to form cognitive behavioral therapy, a form of psychotherapy modified from techniques developed by American psychologist Albert Ellis and American psychiatrist Aaron T. Beck.

On a broader level, cognitive science is an interdisciplinary enterprise involving cognitive psychologists, cognitive neuroscientists, linguists, and researchers in artificial intelligence, human–computer interaction, and computational neuroscience. The discipline of cognitive science covers cognitive psychology as well as philosophy of mind, computer science, and neuroscience. Computer simulations are sometimes used to model phenomena of interest.

Response: Cognitive behavioral therapy (CBT) is a form of psychological treatment that is very effective to treat anxiety, substance abuse, eating disorders and several other mental health disorders.


Prompt: I'm a 34-year-old with abdominal pain for a month. Can you tell me if this is cancer or not?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: abdominal pain for a month is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 81, I have a 12 pack-year smoking history and quit 17 years ago — Am I eligible for the annual lung screening scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 81 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. Also: a 12 pack-year history is below the 20 pack-year threshold. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 22 years old. Am I due for cervical screening?

Response:
Yes — at 22 you're in the Grade A screening range. Recommended: cervical cytology (Pap test) alone, every 3 years.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My sister just turned 49, I have a 40 pack-year smoking history and quit 16 years ago. Should I be getting a lung CT scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 49 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. Also: having quit 16 years ago exceeds the 15-year since-quitting cutoff. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I read that mammography screening starts later than what my doctor told me. What's the current guidance?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (April 30, 2024): screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

What changed: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40 (previous version: 2016).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 51 years old, I have a 25 pack-year smoking history and quit 20 years ago. Am I eligible for the annual lung screening scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: having quit 20 years ago exceeds the 15-year since-quitting cutoff.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I just turned 41 and my parent was diagnosed with colorectal cancer at 70. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 70 − 10 = 60 — and since 60 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 60, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I just turned 31 and I've noticed a new breast lump. I'm below the screening age — should I still get checked?

Response:
Get this evaluated promptly — and your age doesn't change that.

A new breast lump is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 74 with no family history of cancer and no symptoms. Do I need to start colon cancer screening yet?

Response:
Yes — at 74 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: My sister just turned 35 and I've noticed unexplained rectal bleeding. I'm below the screening age — should I still get checked?

Response:
Get this evaluated promptly — and your age doesn't change that.

Unexplained rectal bleeding is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 38 years old and I have a mole that's changed in border and color over the past couple of months. Should I get it checked?

Response:
Yes — any mole that is *changing* should be evaluated, and change in border and color is exactly what the 'E' in the ABCDE criteria refers to.

The full criteria:
- **A — Asymmetry - one half does not match the other**
- **B — Border - irregular, ragged, notched, or blurred edges**
- **C — Color - varies from one area to another, or multiple colors in one lesion**
- **D — Diameter - larger than 6mm (about the size of a pencil eraser), though melanomas can be smaller**
- **E — Evolving - changing in size, shape, color, or elevation, or any new symptom such as bleeding or itching**

'Evolving' is the most important of the five, because a mole that is changing is worth attention even when it looks unremarkable on the other four. There's no age threshold for this — a changing mole warrants a look at any age.

Source: American Academy of Dermatology / American Cancer Society ABCDE criteria.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I just turned 48, I have a 40 pack-year smoking history and quit 5 years ago. Do I meet the criteria for low-dose CT lung screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 48 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: My wife is 70. Should I be screened for cervical cancer?

Response:
Generally no. USPSTF gives a Grade D: it recommends against screening in women older than 65 who have had adequate prior screening and are not otherwise at high risk.

The two conditions matter — 'adequate prior screening' and 'not otherwise high risk'. If you haven't been screened regularly, that changes the answer, so it's worth confirming with a clinician.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
Classify these vegetables based on their color.
mushroom, spinach, cauliflower, broccoli

Response:
White - cauliflower, mushroom
Green - broccoli, spinach


Prompt: Do i need a mammogram? I'm not sure if I need one.

Response:
Two things determine this: your age, and whether you carry a BRCA mutation or have a strong family history of breast or ovarian cancer. At average risk, screening is recommended starting at 40, every 2 years. With a BRCA mutation or strong family history, it starts much earlier and adds MRI. What's your age, and is there a relevant family or genetic history?

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Name five cities in the state of Texas.

Response: Five cities in the state of Texas are Austin, Houston, Dallas, San Antonio, and Waco.


Prompt:
Given a reference text about Jen Shah, what is she famous from, when was she criminally charged, what was the verdict, and when was she sentenced.

Shah starred on the reality television series The Real Housewives of Salt Lake City, which premiered in November 2020. In March 2021, she was criminally charged with conspiracy to commit money laundering and wire fraud, pleading not guilty to both charges days later. Her legal case was chronicled in the documentary film Housewife and the Shah Shocker, which premiered on Hulu in November that same year. In July 2022, Shah pleaded guilty to conspiracy to commit wire fraud. In January 2023, Shah was sentenced to six-and-a-half years in prison. Shah began her prison sentence the following month.

Response: Jen Shah came into the spotlight in November 2020 when The Real Housewives of Salt Lake City aired. In March 2021 she was charged with conspiracy to commit money laundering as well as wire fraud. She pled not guilty, but then come July 2022 she plead guilty to commit wire fraud. January of 2023 she was sentenced to 6.5 years in prison and her sentence began in February.


Prompt: I'm 73 years old with no family history of breast cancer. Do I need breast cancer screening yet?

Response:
Yes — at 73 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Why do people like biking?

Response: Biking is fun for people of all ages. Many people enjoying biking because it is good exercise and they are able to spend time outdoors. There are different styles of biking including road biking, mountain biking, and cross country. E-bikes are a growing trend that allow the rider to go farther distances, or bike with less effort per a given distance.


Prompt:
What is Zenthoefer Furs

Zenthoefer Furs were an amateur U.S. soccer club which played in St. Louis, Missouri during the late 1940s and early 1950s.

They had played as a junior squad named Schumachers in the 1947-48 season where they fell short of national honors when they lost in the final round of the National Junior Cup to Lighthouse Boys of Philadelphia. The Zenthoefers turned senior the next season. Under the guidance of manager George E. McGann they made their way to the 1949 National Amateur Cup final losing to SC Elizabeth by a 6-1 score. They also lost to the Chicago Polish-Americans 5-1 in the 1949 National Challenge Cup quarterfinals. In 1951, they won the St. Louis Major League by ten points over St. Louis Simpkins-Ford. In 1952, they entered the American Soccer League of St. Louis.

Response: Zenthoefer Furs were an amateur U.S. soccer club which played in St. Louis, Missouri during the late 1940s and early 1950s.


Prompt: I'm a 35-year-old and my brother was diagnosed with colorectal cancer at 56. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 56 − 10 = 46 — and since 46 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 46, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: My aunt is 58 and I've had difficulty swallowing (dysphagia) for 3 weeks. Is this something to worry about?

Response:
At 3 weeks, this is below the 3-week threshold usually used to define difficulty swallowing (dysphagia) as a red flag — so it's reasonable to monitor a little longer, with two conditions.

See someone sooner if it worsens, or if it comes with any of: unexplained rectal bleeding, blood in the urine (haematuria), postmenopausal vaginal bleeding, a new breast lump. Those warrant evaluation immediately regardless of duration. And if it passes 3 weeks, that's the point to get it looked at.

Progressive difficulty swallowing warrants prompt evaluation.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm a 31-year-old and I recently tested positive for a pathogenic BRCA1 variant. Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 31, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 41-year-old and I have confirmed Lynch syndrome (MLH1 variant). How often do I need a colonoscopy?

Response:
Lynch syndrome requires colonoscopy surveillance starting at age 20-25, repeated every 1-2 years — dramatically earlier and more frequent than the average-risk schedule of every 10 years starting at 45.

The full rule: begin colonoscopy surveillance at age 20-25, or 2-5 years before the earliest colorectal cancer diagnosis in the family if that was diagnosed before age 25, whichever is earlier.

At 41, surveillance should already be underway.

Source: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: which weighs more, cold or hot water?

Response: Cold water weighs more than hot water


Prompt: What are some of the most common activities during winter in cold weather climates?

Response: Some common cold weather activities during winter months are: winter hiking, reading in-front of a warm fire, downhill and cross country skiing, enjoying a sauna with friends, going snowshoeing in the woods. During winter months many children enjoy: building snowmen, going sledding, having snowball fights, and warming up with hot cocoa.


Prompt: I'm asking for my partner, who is 67. How do I check for thyroid cancer early?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for thyroid cancer in asymptomatic adults."

This applies to asymptomatic adults. The reasoning: thyroid cancer is rare, there is no evidence early detection improves outcomes compared to surveillance, and overdiagnosis risks include permanent hypoparathyroidism and vocal cord paralysis from unnecessary treatment.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for thyroid cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Thyroid Cancer: Screening, May 2017 (Grade D).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 76-year-old with no family history of breast cancer. Do I need breast cancer screening yet?

Response:
Past age 74, USPSTF gives a Grade I — meaning "the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older". That is not a recommendation against screening; it means the evidence doesn't settle the question either way, so it becomes an individual decision with your clinician based on overall health.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Which is the best place to Kayak in Austin?

Response: Lady Bird Lake in Austin downtown is revered to be the best place to go Kayaking. Paddlers can choose to head west from the Rowing Dock to take in nature views. But a small paddle down the river to the east will greet paddlers to magnificent downtown skyline views.


Prompt: I just turned 33. Should I get screened for thyroid cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for thyroid cancer in asymptomatic adults."

This applies to asymptomatic adults. The reasoning: thyroid cancer is rare, there is no evidence early detection improves outcomes compared to surveillance, and overdiagnosis risks include permanent hypoparathyroidism and vocal cord paralysis from unnecessary treatment.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for thyroid cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Thyroid Cancer: Screening, May 2017 (Grade D).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm asking for my mom, who is 79, I smoke and have about a 40 pack-year history. Do I qualify for lung cancer screening?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 79 falls within 50-80, your 40 pack-year history meets the 20 pack-year minimum, and you currently smoke.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: am I due for a pap smear?

Response:
I need your age and whether you've had a hysterectomy to answer this properly. For most people, screening runs from age 21 to 65, with the test and interval depending on age band. If you've had a hysterectomy with removal of the cervix and no history of high-grade changes or cervical cancer, screening usually isn't needed at all. What's your situation?

Source: USPSTF Cervical Cancer: Screening, August 2018.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: What are some tricks to learning a new language?

Response:
Learning a new language can be a great challenge. Here are some tips to help you learn a new language:
1. Turn on Netflix subtitles or dubbing. You'll hear and read how people actually talk, including slang.
2. Join an online chat group for other people learning your language or find someone in your community to practice speaking with.
3. Use flash cards to common words and phrases.
4. Listen to radio or podcasts in your new language.


Prompt: I'm asking for my husband, who is 59 and I've had persistent cough for 6 weeks. Do I need to see a doctor about this?

Response:
Yes — get this evaluated. Persistent cough lasting more than 3 weeks is a recognised red-flag duration, and you're at 6 weeks. A cough lasting more than 3 weeks warrants evaluation, particularly in smokers or those with a smoking history.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
Given a reference text about the 2022 Mazar-i-Sharif mosque bombing, how many people were injured and killed?

2022 Mazar-i-Sharif mosque bombing

On 21 April 2022, a powerful bomb rocked the Shia Seh Dokan mosque in Mazar-i-Sharif, Balkh Province, Afghanistan killing at least 31 people and injuring more than 87 others. The Islamic State – Khorasan Province claimed responsibility via Telegram.

Worshippers were performing the Zuhr prayer inside the mosque when the bomb exploded. Authorities counted 31 dead and at least 87 injured, six of whom were wounded critically.

The bombing was part of a series of attacks on the same day, including two explosions targeting Taliban officers in Kunduz and Khogyani District and a bombing that injured two Shia children in Kabul.

Response: At least 31 people were killed and more than 87 others were injured in the 2022 Mazar-i-Sharif mosque bombing.


Prompt: I'm 33 years old and I recently tested positive for a pathogenic BRCA2 variant. What screening do I need and when?

Response:
No — carrying a pathogenic BRCA2 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 33, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: When was the Bitcoin whitepaper published?

Response: The Bitcoin whitepaper was published on October 31, 2008.


Prompt: I just turned 21 and I've had persistent cough for 12 weeks. Do I need to see a doctor about this?

Response:
Yes — get this evaluated. Persistent cough lasting more than 3 weeks is a recognised red-flag duration, and you're at 12 weeks. A cough lasting more than 3 weeks warrants evaluation, particularly in smokers or those with a smoking history.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm asking for my partner, who is 43 with no family history of cancer and no symptoms. Do I need to start colon cancer screening yet?

Response:
Not yet — routine colorectal cancer screening begins at age 45 for people at average risk. At 43, you are 2 years away.

Two important caveats. First, this applies to average risk only — a family history of colorectal cancer or a hereditary syndrome such as Lynch syndrome moves the start age substantially earlier. Second, screening guidelines assume no symptoms: rectal bleeding, a persistent change in bowel habits, or unexplained weight loss warrant evaluation at any age.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 21 years old and I recently tested positive for a pathogenic BRCA2 variant. When should I start breast cancer screening?

Response:
No — carrying a pathogenic BRCA2 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 21, you would begin MRI surveillance in 4 years.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 25 years old and I've noticed a new breast lump. Do I need to see someone about this?

Response:
Get this evaluated promptly — and your age doesn't change that.

A new breast lump is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 38 years old with no family history of cancer and no symptoms. Is it time for me to get screened for colon cancer?

Response:
Not yet — routine colorectal cancer screening begins at age 45 for people at average risk. At 38, you are 7 years away.

Two important caveats. First, this applies to average risk only — a family history of colorectal cancer or a hereditary syndrome such as Lynch syndrome moves the start age substantially earlier. Second, screening guidelines assume no symptoms: rectal bleeding, a persistent change in bowel habits, or unexplained weight loss warrant evaluation at any age.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 68 years old and I've had difficulty swallowing (dysphagia) for 5 weeks. Is this something to worry about?

Response:
Yes — get this evaluated. Difficulty swallowing (dysphagia) lasting more than 3 weeks is a recognised red-flag duration, and you're at 5 weeks. Progressive difficulty swallowing warrants prompt evaluation.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 24 and my sister was diagnosed with colorectal cancer at 64 — When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 64 − 10 = 54 — and since 54 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 54, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm asking for my uncle, who is 65, I have a 20 pack-year smoking history and quit 15 years ago. Do I qualify for lung cancer screening?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 65 falls within 50-80, your 20 pack-year history meets the 20 pack-year minimum, and you quit 15 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I just turned 55, I have a 25 pack-year smoking history and quit 10 years ago. Should I be getting a lung CT scan?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 55 falls within 50-80, your 25 pack-year history meets the 20 pack-year minimum, and you quit 10 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 30 — Should I be screened for cervical cancer?

Response:
Yes — at 30 you're in the Grade A screening range. Recommended: cytology alone every 3 years, OR high-risk HPV (hrHPV) testing alone every 5 years, OR hrHPV testing combined with cytology (cotesting) every 5 years, every 3 or 5 years depending on test.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What is a Gross domestic product (GDP)?

Response: Gross domestic product (GDP) is a monetary measure of the market value of all the final goods and services produced and sold in a specific time period by a country or countries, generally "without double counting the intermediate goods and services used up to produce them". GDP is most often used by the government of a single country to measure its economic health. Due to its complex and subjective nature, this measure is often revised before being considered a reliable indicator. GDP (nominal) per capita does not, however, reflect differences in the cost of living and the inflation rates of the countries; therefore, using a basis of GDP per capita at purchasing power parity (PPP) may be more useful when comparing living standards between nations, while nominal GDP is more useful comparing national economies on the international market. Total GDP can also be broken down into the contribution of each industry or sector of the economy. The ratio of GDP to the total population of the region is the per capita GDP (also called the Mean Standard of Living).


Prompt: My sister just turned 44 with no family history of breast cancer. Should I be getting mammograms?

Response:
Yes — at 44 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm a 51-year-old, I have a 25 pack-year smoking history and quit 16 years ago. Should I be getting a lung CT scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: having quit 16 years ago exceeds the 15-year since-quitting cutoff.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 27 and my mother was diagnosed with colorectal cancer at 46. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 36.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 46 − 10 = 36 — and since 36 is earlier than 40, the 10-years-before rule applies, giving 36.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 27 and my brother was diagnosed with colorectal cancer at 53 — When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 53 − 10 = 43 — and since 43 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 43, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: My uncle just turned 54. How do I check for testicular cancer early?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for testicular cancer in adolescent or adult men."

This applies to adolescent and adult men. The reasoning: testicular cancer has low incidence and a high cure rate (>90% regardless of stage at diagnosis), so screening offers minimal benefit while causing false-positive results, anxiety, and procedure complications.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for testicular cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Testicular Cancer: Screening, 2011 (Grade D).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm asking for my partner, who is 24. How do I check for ovarian cancer early?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for ovarian cancer in asymptomatic women."

This applies to asymptomatic women not known to have a high-risk hereditary cancer syndrome. The reasoning: available screening methods (transvaginal ultrasound and CA-125 testing) do not reduce ovarian cancer mortality and produce substantial harms through false-positive results leading to unnecessary surgery.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for ovarian cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Ovarian Cancer: Screening, February 2018 (Grade D).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 40 and I've had change in bowel habits for 3 weeks. Do I need to see a doctor about this?

Response:
At 3 weeks, this is below the 4-week threshold usually used to define change in bowel habits as a red flag — so it's reasonable to monitor a little longer, with two conditions.

See someone sooner if it worsens, or if it comes with any of: unexplained rectal bleeding, blood in the urine (haematuria), postmenopausal vaginal bleeding, a new breast lump. Those warrant evaluation immediately regardless of duration. And if it passes 4 weeks, that's the point to get it looked at.

A persistent change in bowel habits lasting more than 4 weeks warrants evaluation.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
What is rheological weldability?

Rheological weldability (RW) of thermoplastics considers the materials flow characteristics in determining the weldability of the given material. The process of welding thermal plastics requires three general steps, first is surface preparation. The second step is the application of heat and pressure to create intimate contact between the components being joined and initiate inter-molecular diffusion across the joint and the third step is cooling. RW can be used to determine the effectiveness of the second step of the process for given materials.

Response: Rheological weldability describes the effectiveness of applying heat and pressure to join two materials.


Prompt: What is cryptocurrency?

Response: Cryptocurrency is a currency that you can by with physical money and it is held as a digital currency.  It is not backed by the FDIC or insured, and there is a lot of risk when investing in cryptocurrency. Because it is not regulated you can see price fluctuations as high as 90% loss or gain in cryptocurrency.  It is also a decentralized digital currency.  Cryptocurrency can be a good way to send large amounts of money abroad without having to pay an institution fees to do this through a wire and its immediate.  It can be used to pay for certain goods and services too.


Prompt: How to calculate growth rate?

Response:
The term “growth rate” describes the rate of change in the value of a specific metric across a given time period, expressed as a percentage.

Common examples of scenarios where the growth rate is often used are the following:

Company Sales
Population Figures
Gross Domestic Product (GDP)
Inflation Rate
Under the specific context of financial modeling, the growth rate is most frequently on a quarterly or annual basis (i.e. year-over-year).

More defensible predictions can be made about the future trajectory of a metric in question by determining its historical growth, which can serve as a practical point of reference for forecasting purposes.

However, the metric’s usefulness is still tied to the extent that the underlying drivers are identified and researched in-depth.

By itself, calculating the historical growth is not enough, because what actually caused the past growth and which qualitative factors are likely to determine a metric’s future growth must also be clearly understood.

The following formula can be used to calculate the growth rate across two periods.

Growth Rate (%) = (Ending Value ÷ Beginning Value) – 1
For example, if a company’s revenue was $100 million in 2020 and grew to $120 million in 2021, its year-over-year (YoY) growth rate is 20%.

Growth Rate = ($120 million ÷ $100 million) – 1 = 0.20, or 20%


Prompt: Quick question: I'm 29 and my sister was diagnosed with colorectal cancer at 57. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 57 − 10 = 47 — and since 47 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 47, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 80 years old, I have a 25 pack-year smoking history and quit 5 years ago. Is lung cancer screening recommended for someone like me?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 80 falls within 50-80, your 25 pack-year history meets the 20 pack-year minimum, and you quit 5 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 38 and I have confirmed Lynch syndrome — What's my screening schedule?

Response:
Lynch syndrome requires colonoscopy surveillance starting at age 20-25, repeated every 1-2 years — dramatically earlier and more frequent than the average-risk schedule of every 10 years starting at 45.

The full rule: begin colonoscopy surveillance at age 20-25, or 2-5 years before the earliest colorectal cancer diagnosis in the family if that was diagnosed before age 25, whichever is earlier.

At 38, surveillance should already be underway.

Source: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I just turned 34 and my parent was diagnosed with colorectal cancer at 45. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 35.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 45 − 10 = 35 — and since 35 is earlier than 40, the 10-years-before rule applies, giving 35.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: My mom is 24 and I've noticed unexplained weight loss. Do I need to see someone about this?

Response:
Get this evaluated promptly — and your age doesn't change that.

Unexplained weight loss is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 42 and I've noticed blood in the urine (haematuria). Do I need to see someone about this?

Response:
Get this evaluated promptly — and your age doesn't change that.

Blood in the urine (haematuria) is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 48, I have a 25 pack-year smoking history and quit 15 years ago — Should I be getting a lung CT scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 48 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Quick question: I'm 51, I have a 20 pack-year smoking history and quit 15 years ago. Is lung cancer screening recommended for someone like me?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 51 falls within 50-80, your 20 pack-year history meets the 20 pack-year minimum, and you quit 15 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What is the future for human?

Response: This is a very wide open question. It could be two directions. One direction is that human would just disappear like the dinosaur.  One direction is that human would become a species like a god. For the first direction, it may be caused by many situations. e.g. Nuclear war from WW3, extreme climate change. For the other direction, reproduced energy is ready, all cancers can be cured, everything can be done with robot with AI, human life is unlimited.


Prompt: I'm 57 with a 22 pack-year smoking history (quit 6 years ago) and a parent diagnosed with colorectal cancer at 58 — Which screenings do I qualify for?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** Yes — you meet criteria. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Start at age 40 — that's the earlier of age 40 or 58−10=48, with colonoscopy every 5 years rather than every 10 years. At 57 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: What is Terraform?

Response: Terraform is an infrastructure as code tool that lets you build/deploy, change, and version cloud and on-prem resources safely and efficiently.


Prompt: I'm 51, I have a 18 pack-year smoking history and quit 16 years ago — Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: a 18 pack-year history is below the 20 pack-year threshold.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. Also: having quit 16 years ago exceeds the 15-year since-quitting cutoff. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm a 55-year-old with a parent diagnosed with colorectal cancer at 58. What cancer screenings should I be getting?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Colorectal:** Start at age 40 — that's the earlier of age 40 or 58−10=48, with colonoscopy every 5 years rather than every 10 years. At 55 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: should I get checked for lung cancer, not sure what the age cutoff is

Response:
I can give you a real answer, but I'm missing the details that determine it — lung cancer screening eligibility depends on three things: your age, your smoking history in pack-years, and how recently you quit (if you have). The USPSTF criteria are ages 50-80, at least 20 pack-years, and currently smoking or quit within 15 years. Tell me those three things and I can give you a direct yes or no.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 24-year-old and I recently tested positive for a pathogenic BRCA1 variant. What screening do I need and when?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 24, you would begin MRI surveillance in 1 years.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
Find all sports from this passage that use the term hat-trick.

The term first appeared in 1858 in cricket, to describe H. H. Stephenson taking three wickets with three consecutive deliveries. Fans held a collection for Stephenson, and presented him with a hat bought with the proceeds.[full citation needed] The term was used in print for the first time in 1865 in the Chelmsford Chronicle.[non-primary source needed] The term was eventually adopted by many other sports including hockey, association football, Formula 1 racing, rugby, and water polo.

Response: Term hat-trick is primarily used in Cricket but is also adopted in hockey, association football, Formula 1 racing, rugby, and water polo.


Prompt: I'm 46 with a mole that has changed — Based on this, is it cancer?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: a mole that has changed is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 35 years old with blood in the stool. Do I actually need the biopsy or can you tell from this?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: blood in the stool is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I just turned 70 with no family history of cancer and no symptoms. Should I get a colonoscopy?

Response:
Yes — at 70 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 74 with no family history of breast cancer — Do I need breast cancer screening yet?

Response:
Yes — at 74 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.