Prompt: I'm a 60-year-old, I smoke and have about a 40 pack-year history. Is lung cancer screening recommended for someone like me?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 60 falls within 50-80, your 40 pack-year history meets the 20 pack-year minimum, and you currently smoke.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What are 5 potential uses for an empty La Croix can?

Response:
1. Make your bike sound like it has an engine by wrapping the can around the back tire.
2. A percussion instrument to play along with friends in a jam session.  You could just crinkle it, hit it with a pen, or fill it with sand or debris and shake it.
3. A baking tool.  You can used the bottom of the can to stamp out perfectly circle, uniform cookies from a rolled-out sheet of cookie dough.
4. A field razor.  Tear the can carefully to create an effective cutting device for emergency use.
5. A make shift ball to throw around with friends at the park. An empty can could be a fun projectile to use in a friendly game of 3 Flies Up.


Prompt: What qualifies an animal as a monotreme?

Response: A monotreme is a mammal that lays eggs.  This is uncommon as there are only two mammals, the echidnas and platypus, that do so.  The majority of mammals give placenta birth, with another minority of mammals, known as marsupials, give birth to a fetus-like embryo which is dependent of mother's teat to provide nourishment until fully developed.


Prompt: Which inventions of the 20th century had the greatest positive impact on human lifespan?

Response: It would be hard to argue against vaccinations or antibiotics, which have combined to limit or eliminate many life-threatening diseases throughout most of the world, such as polio, tuberculosis, and bacterial infections. Improved labor and delivery practices have significantly cut down maternal and infant morbidity rates. Electricity and synthetic fertilizers have also played key roles in establishing safe and plentiful food supply chains. There are many other examples as well.


Prompt: I'm a 76-year-old with no family history of breast cancer. Should I be getting mammograms?

Response:
Past age 74, USPSTF gives a Grade I — meaning "the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older". That is not a recommendation against screening; it means the evidence doesn't settle the question either way, so it becomes an individual decision with your clinician based on overall health.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I just turned 25 and I recently tested positive for a pathogenic BRCA2 variant. What screening do I need and when?

Response:
No — carrying a pathogenic BRCA2 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 25, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Did Sir Winston Churchill win the Nobel Peace Prize?

Response:
No, Sir Winston Churchill did not win the Nobel Peace Prize. He was nominated for the Nobel Peace Prize twice, in 1945 and in 1950, and did not win it.
However, he did win the Nobel Prize in Literature in 1953.


Prompt: My aunt is 44 with no family history of cancer and no symptoms. Is it time for me to get screened for colon cancer?

Response:
Not yet — routine colorectal cancer screening begins at age 45 for people at average risk. At 44, you are 1 year away.

Two important caveats. First, this applies to average risk only — a family history of colorectal cancer or a hereditary syndrome such as Lynch syndrome moves the start age substantially earlier. Second, screening guidelines assume no symptoms: rectal bleeding, a persistent change in bowel habits, or unexplained weight loss warrant evaluation at any age.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
Given this reference text about Jimmy John's, how many Jimmy John's locations are there?

Jimmy John's is an American sandwich chain headquartered in Champaign, Illinois. The business was founded by Jimmy John Liautaud in 1983. After Liautaud graduated from high school, his father gave him a choice to either join the military or start a business. Liautaud, choosing the latter, initially decided to start a hot dog business, but changed to opening a sandwich business due to costs.

The Jimmy John's franchise has over 2700 locations, with 98% of them being franchises. in 2016, Roark Capital Group purchased a majority stake in the company. Later, in 2019, Inspire Brands purchased the company from Roark Capital Group for an unspecified amount.

Response: There are currently 2700 locations in the Jimmy John's franchise.


Prompt:
What is the current capital of Japan?

Tokyo (/ˈtoʊkioʊ/; Japanese: 東京, Tōkyō, [toːkʲoː] (listen)), officially the Tokyo Metropolis (東京都, Tōkyō-to), is the capital and most populous city of Japan. Formerly known as Edo, its metropolitan area (13,452 square kilometers or 5,194 square miles) is the most populous in the world, with an estimated 37.468 million residents as of 2018; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Japan's economic center and is the seat of both the Japanese government and the Emperor of Japan.

Response: Tokyo is the current capital of Japan.


Prompt: do I need a colonoscopy?

Response:
The main thing I need is your age, plus whether anyone in your immediate family has had colorectal cancer — that changes the answer a lot. For someone at average risk, screening starts at 45. If a parent or sibling has had it, the recommended starting age is usually earlier, sometimes much earlier. What's your age, and is there a family history?

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm asking for my wife, who is 60 with no family history of cancer and no symptoms. Am I due for colorectal cancer screening?

Response:
Yes — at 60 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 81 years old, I have a 12 pack-year smoking history and quit 20 years ago. Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 81 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. Also: a 12 pack-year history is below the 20 pack-year threshold. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm asking for my brother, who is 45. What's the screening test for testicular cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for testicular cancer in adolescent or adult men."

This applies to adolescent and adult men. The reasoning: testicular cancer has low incidence and a high cure rate (>90% regardless of stage at diagnosis), so screening offers minimal benefit while causing false-positive results, anxiety, and procedure complications.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for testicular cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Testicular Cancer: Screening, 2011 (Grade D).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
Who is Cindy Robinson?

Cindy Robinson is an American voice actress who voices in animations and video games. Some of her major roles are Makoto Nanaya and Gii from the Blazblue series, Betty Boop in commercials, Queen Beryl in Sailor Moon, Chitose Nanbu in Ah My Buddha, Kukaku Shiba, Miyako Shiba, Jinta Hanakari (kid) and Kiyone Kotetsu in Bleach, Zola in the Blue Dragon series, Madeline Hatter in "Ever After High" Minerva and Hinoka in Fire Emblem. She also makes an uncredited appearance as the voice of the Purge Emergency Broadcast System in The Purge franchise.

Robinson is best known for her role as Amy Rose in the Sonic the Hedgehog franchise since 2010.

Response: Cindy Robinson is an American voice actress best known for her role as Amy Rose in the Sonic the Hedgehog franchise since 2010.


Prompt: My mother just turned 33 and my parent had colon cancer diagnosed at 52. When do I need my first colonoscopy?

Response:
You should begin at age 40 — not 42.

This is a common miscalculation. The rule is: start at age 40, OR 10 years before the youngest affected relative's diagnosis, whichever is EARLIER. Here, 52 − 10 = 42, but 40 comes earlier than 42, so 40 is the answer. Applying only the subtraction step would delay screening by two years.

Interval: colonoscopy every 5 years.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: How should you care for grapes?

Response: Grapes like sandy soil that is not too wet, so make sure to let the ground dry between waterings. Grapes often grow far more fruit than they can sustainably produce. Prune them aggressively in the early spring before the sap starts to flow while it is still cold. One method of pruning is to leave two to four vine lengths with about 10-15 buds each from the last year's growth, and leave a joint for this years growth to grow. Wire these vine lengths up to your trellis, and enjoy the grapes in the fall!


Prompt: How to give a good presentation?

Response: Any good presentations should be well-timed. The presenter should make eye contact with the audience. They should also make use of power pauses - count "1, 2, 3, 4, 5" - before moving on. It may sound awkward for you but silence can be immensely powerful for audience to absorb the message. Don't be afraid to be yourself on the stage. Be mindful of your body language on the stage. Don't pace like a lion and find your resting pose. The most important thing though, is to practice! Just as how you wouldn't show up to a swimming competition without ever practicing swimming, you wouldn't just stand on the stage and expect to be able to give a good presentation. Practice is key!


Prompt: I'm 33 years old and my parent had colon cancer diagnosed at 52. When do I need my first colonoscopy?

Response:
You should begin at age 40 — not 42.

This is a common miscalculation. The rule is: start at age 40, OR 10 years before the youngest affected relative's diagnosis, whichever is EARLIER. Here, 52 − 10 = 42, but 40 comes earlier than 42, so 40 is the answer. Applying only the subtraction step would delay screening by two years.

Interval: colonoscopy every 5 years.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: How much of American wine is produced in California?

Response: California is responsibly for roughly 90% of American wine production


Prompt:
How are the characters Balrog, Vega and M. Bison connected in Street Fighter II?

Balrog, an American boxer with a similar appearance to Mike Tyson. Called M. Bison in Japan. Once one of the world's greatest heavyweight boxers, he began working for Shadaloo for easy money. Vega, a Spanish bullfighter who wields a claw and uses a unique style of ninjutsu. Called Balrog in Japan. He is vain and wishes to eliminate ugly people from the world. Sagat, a Muay Thai kickboxer from Thailand and former World Warrior champion from the original Street Fighter. He was once known as The King of Street Fighters until he got demoted as The King of Muai Thai in his own tournament due to a narrow defeat at the hands of Ryu's shoryuken (rising dragon punch) which left a deep gash across his chest. Ever since that moment he felt disgrace, and will do anything to have a grudge match with Ryu to get his title back, even if it takes joining forces with Shadaloo. M. Bison, the leader of the criminal organization Shadaloo, who uses a mysterious power known as Psycho Power, and the final opponent of the game. Called Vega in Japan.

Response: Balrog, an American boxer who resembles Mike Tyson, is called M. Bison in Japan. Vega, a Spanish bullfighter with a claw is called Balrog in Japan. M. Bison, the final opponent of the game, is called Vega in Japan.


Prompt: My friend said the age for lung cancer screening is different now — is that right?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (2021): annual low-dose computed tomography (LDCT) for ages 50-80 with at least 20 pack-years, currently smoking or quit within 15 years, Grade B.

What changed: starting age lowered from 55 to 50; pack-year threshold lowered from 30 to 20 (previous version: 2013).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 65. Am I due for cervical screening?

Response:
Yes — at 65 you're in the Grade A screening range. Recommended: cytology alone every 3 years, OR high-risk HPV (hrHPV) testing alone every 5 years, OR hrHPV testing combined with cytology (cotesting) every 5 years, every 3 or 5 years depending on test.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Think up 5 different reasons to give my boss to take off work.

Response:
Here are 5 different reasons you can give your boss to take off work:
1. You have to go to your kid's award ceremony
2. You got food poisoning
3. The power at your house went out
4. You car is in the shop and you have no ride to work
5. Your family made a surprise visit to see you.


Prompt: Which ones are metals and non metals: Copper, Hydrogen, Silver, Carbon, Gold, Nitrogen

Response:
Metals: Copper, Silver, Gold
Non Metals: Hydrogen, Carbon, Nitrogen


Prompt: I'm 28 and my sister was diagnosed with colorectal cancer at 64 — When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 64 − 10 = 54 — and since 54 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 54, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
Where did Gretel attend primary school?

Gretel Beer was born in Vienna into a Jewish family. She was mostly raised by her aunt Olga Springer (Bechin, Bohemia 1879–1942 Maly Trostenets extermination camp) the widow of a physician (in 1937: 9th district, Porzellangasse 45), as her mother Regina Weidenfeld née Pisk died when Margaret was six years old and her father, Dionys (Duny) Weidenfeld, did not keep up a household. (At Porzellangasse, until 1938 Eric Pleskow and Ari Rath spent their childhood, as they told the Austrian broadcaster ORF in 2012.) After attending primary school at Marchegg, a small town east of Vienna near the border with Slovakia, she attended a federal Realschule at Vereinsgasse in Vienna's 2nd district, where many Jewish Viennese lived.

In the spring of 1938, after the annexation of Austria by Germany, she and 48 other pupils were forced to leave this school and attend a Jewish class elsewhere in Vienna. At the entrance hall of her school, which is now called Bundesrealgymnasium Vereinsgasse, since 1989 the names of the expelled pupils are displayed on a memorial inscription.

Response: Gretel Beer attended primary school in Marchegg, in east of Vienna.


Prompt: I'm asking for my mother, who is 60, I have a 18 pack-year smoking history and quit 10 years ago. Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: a 18 pack-year history is below the 20 pack-year threshold.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm asking for my partner, who is 23 and I've noticed unexplained weight loss. Is this urgent or can it wait?

Response:
Get this evaluated promptly — and your age doesn't change that.

Unexplained weight loss is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 42 years old and I recently tested positive for a pathogenic BRCA2 variant. When should I start breast cancer screening?

Response:
No — carrying a pathogenic BRCA2 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 42, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt:
Who coined the phrase "Bike-shedding" and when?

The law of triviality is C. Northcote Parkinson's 1957 argument that people within an organization commonly or typically give disproportionate weight to trivial issues. Parkinson provides the example of a fictional committee whose job was to approve the plans for a nuclear power plant spending the majority of its time on discussions about relatively minor but easy-to-grasp issues, such as what materials to use for the staff bicycle shed, while neglecting the proposed design of the plant itself, which is far more important and a far more difficult and complex task.

The law has been applied to software development and other activities. The terms bicycle-shed effect, bike-shed effect, and bike-shedding were coined based on Parkinson's example; it was popularised in the Berkeley Software Distribution community by the Danish software developer Poul-Henning Kamp in 1999 and, due to that, has since become popular within the field of software development generally.

Argument

A bicycle shed
The concept was first presented as a corollary of his broader "Parkinson's law" spoof of management. He dramatizes this "law of triviality" with the example of a committee's deliberations on an atomic reactor, contrasting it to deliberations on a bicycle shed. As he put it: "The time spent on any item of the agenda will be in inverse proportion to the sum [of money] involved." A reactor is so vastly expensive and complicated that an average person cannot understand it (see ambiguity aversion), so one assumes that those who work on it understand it. However, everyone can visualize a cheap, simple bicycle shed, so planning one can result in endless discussions because everyone involved wants to implement their own proposal and demonstrate personal contribution.

After a suggestion of building something new for the community, like a bike shed, problems arise when everyone involved argues about the details. This is a metaphor indicating that it is not necessary to argue about every little feature based simply on having the knowledge to do so. Some people have commented that the amount of noise generated by a change is inversely proportional to the complexity of the change.

The law of triviality is supported by behavioural research. People tend to spend more time on small decisions than they should, and less time on big decisions than they should. A simple explanation is that during the process of making a decision, one has to assess whether enough information has been collected to make the decision. If people make mistakes about whether they have enough information, they will tend to stop too early for big decisions. The reason is that big decisions require collecting information for a long time. It leaves more time to make a mistake (and stop) before getting enough information. Conversely, for small decisions, where people should stop early, they may continue to ponder for too long by mistake.

Related principles and formulations
There are several other principles, well-known in specific problem domains, which express a similar sentiment.

Wadler's law, named for computer scientist Philip Wadler, is a principle which asserts that the bulk of discussion on programming-language design centers on syntax (which, for purposes of the argument, is considered a solved problem), as opposed to semantics.

Sayre's law is a more general principle, which holds (among other formulations) that "In any dispute, the intensity of feeling is inversely proportional to the value of the issues at stake"; many formulations of the principle focus on academia.

Response: The phrase "bike-shedding" was introduced in 1957 by C. Northcote Parkinson.


Prompt: My dad just turned 82, I have a 21 pack-year smoking history and quit 14 years ago. Do I meet the criteria for low-dose CT lung screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 82 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 65 years old. What's the screening test for thyroid cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for thyroid cancer in asymptomatic adults."

This applies to asymptomatic adults. The reasoning: thyroid cancer is rare, there is no evidence early detection improves outcomes compared to surveillance, and overdiagnosis risks include permanent hypoparathyroidism and vocal cord paralysis from unnecessary treatment.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for thyroid cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Thyroid Cancer: Screening, May 2017 (Grade D).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I just turned 35 and I have confirmed Lynch syndrome (PMS2 variant). When should I start colonoscopies and how often?

Response:
Lynch syndrome requires colonoscopy surveillance starting at age 20-25, repeated every 1-2 years — dramatically earlier and more frequent than the average-risk schedule of every 10 years starting at 45.

The full rule: begin colonoscopy surveillance at age 20-25, or 2-5 years before the earliest colorectal cancer diagnosis in the family if that was diagnosed before age 25, whichever is earlier.

Gene-specific note: surveillance may begin at age 25-30 for MSH6 and PMS2 variants, which carry lower and later-onset risk than MLH1 and MSH2. At 35, surveillance should already be underway.

Source: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I just turned 70. Am I due for cervical screening?

Response:
Generally no. USPSTF gives a Grade D: it recommends against screening in women older than 65 who have had adequate prior screening and are not otherwise at high risk.

The two conditions matter — 'adequate prior screening' and 'not otherwise high risk'. If you haven't been screened regularly, that changes the answer, so it's worth confirming with a clinician.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 24 and I recently tested positive for a pathogenic BRCA1 variant — Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 24, you would begin MRI surveillance in 1 years.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 38 — Should I get screened for ovarian cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for ovarian cancer in asymptomatic women."

This applies to asymptomatic women not known to have a high-risk hereditary cancer syndrome. The reasoning: available screening methods (transvaginal ultrasound and CA-125 testing) do not reduce ovarian cancer mortality and produce substantial harms through false-positive results leading to unnecessary surgery.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for ovarian cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Ovarian Cancer: Screening, February 2018 (Grade D).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Help me come up with 3 ideas for a new business and how I can start it

Response:
There are many businesses you could think about creating. Here are a few examples:
- Services: you can create a firm that provides services such as marketing, technical consulting, or strategic advising. You can start this business by examining your professional expertise, building marketing materials, and networking to find your first customers.
- Product: you can create a product in a domain you're passionate about is a great way of starting a business. This could be small scale boutique items such as candles or soaps made at home and sold at local markets or on a website like Etsy. This could also include something mass manufactured, either contracted out or involving significant capital expenditure in order to start development.
- Training: you can start a training or education program in an industry where you have expertise. There are online platforms for hosting content and managing payments. You can also leverage social media in order to build a funnel of customers.
There are many different potential businesses you might create but services, product, and training businesses are good domains to examine as you look to start your business.


Prompt: My friend said the age for colorectal cancer screening is different now — is that right?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (May 18, 2021): screening begins at age 45 (Grade B for 45-49, Grade A for 50-75).

What changed: starting age lowered from 50 to 45 (previous version: 2016).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What's the current USPSTF recommendation for mammography screening, and did it change?

Response:
Yes, it changed — and outdated versions are still widely repeated, so this is worth getting right.

Current guidance (April 30, 2024): screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

What changed: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40 (previous version: 2016).

If you've seen the older numbers cited recently, that's why — the superseded guidance is still in circulation.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 45-year-old and I recently tested positive for a pathogenic BRCA1 variant. When should I start breast cancer screening?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 45, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm asking for my wife, who is 75 with no family history of breast cancer. Do I need breast cancer screening yet?

Response:
Past age 74, USPSTF gives a Grade I — meaning "the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older". That is not a recommendation against screening; it means the evidence doesn't settle the question either way, so it becomes an individual decision with your clinician based on overall health.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 35-year-old. What's the screening test for thyroid cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for thyroid cancer in asymptomatic adults."

This applies to asymptomatic adults. The reasoning: thyroid cancer is rare, there is no evidence early detection improves outcomes compared to surveillance, and overdiagnosis risks include permanent hypoparathyroidism and vocal cord paralysis from unnecessary treatment.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for thyroid cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Thyroid Cancer: Screening, May 2017 (Grade D).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My partner is 60. Do I need a Pap smear?

Response:
Yes — at 60 you're in the Grade A screening range. Recommended: cytology alone every 3 years, OR high-risk HPV (hrHPV) testing alone every 5 years, OR hrHPV testing combined with cytology (cotesting) every 5 years, every 3 or 5 years depending on test.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Identify which car manufacturer is German or American: Opel, GMC

Response: Opel is German, GMC is American


Prompt: I just turned 67. Is there a test I should get for testicular cancer?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for testicular cancer in adolescent or adult men."

This applies to adolescent and adult men. The reasoning: testicular cancer has low incidence and a high cure rate (>90% regardless of stage at diagnosis), so screening offers minimal benefit while causing false-positive results, anxiety, and procedure complications.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for testicular cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Testicular Cancer: Screening, 2011 (Grade D).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 55-year-old, I have a 40 pack-year smoking history and quit 5 years ago. Should I be getting a lung CT scan?

Response:
Yes — you meet the USPSTF criteria for lung cancer screening. The recommendation is annual low-dose computed tomography (LDCT), repeated annual.

You meet all three requirements: age 55 falls within 50-80, your 40 pack-year history meets the 20 pack-year minimum, and you quit 5 years ago, within the 15-year cutoff.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B). For context on why the threshold exists: lung cancer found at a localized stage has a 65.5% 5-year relative survival rate, versus 10.5% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What is Adderall?

Response:
Adderall is a brand name for a combination drug called mixed amphetamine salts. The mixture contains four salts of amphetamines including equal parts racemic amphetamine and dextroamphetamine, which produces a 3 to 1 ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. Adderall increases activity in the central nervous system and stimulates the release of dopamine and other neurotransmitters, such as serotonin

 Adderall is generally considered effective in treating symptoms of ADHD and narcolepsy. At normal recommended doses, Adderall improves focus, increases energy levels and decreases fidgeting, impulsivity, restlessness and aggression.


Prompt: Name some famous rock bands from the 1960s

Response: The 1960s had a number of famous rock bands including The Beatles, The Beach Boys, The Doors, The Rolling Stones, The Who, Led Zeppelin, The Grateful Dead, Pink Floyd, and many more.


Prompt:
Who is William Crump?

William Crump or Crompe (born by 1479 – 1516 or later), of Canterbury, Kent, was an English politician.

Response: Crump was a common councilman of Canterbury by 1500, chamberlain in 1503–1505, an alderman by 1505 and Mayor of Canterbury for 1505–06 and 1509–10. He was elected a Member of Parliament for Canterbury, Kent in 1510.


Prompt: I'm 47 and I've had change in bowel habits for 1 week — Is this something to worry about?

Response:
At 1 week, this is below the 4-week threshold usually used to define change in bowel habits as a red flag — so it's reasonable to monitor a little longer, with two conditions.

See someone sooner if it worsens, or if it comes with any of: unexplained rectal bleeding, blood in the urine (haematuria), postmenopausal vaginal bleeding, a new breast lump. Those warrant evaluation immediately regardless of duration. And if it passes 4 weeks, that's the point to get it looked at.

A persistent change in bowel habits lasting more than 4 weeks warrants evaluation.

Source: American Cancer Society CAUTION warning signs of cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Quick question: I'm 62 with a 15 pack-year smoking history (quit 6 years ago). Which screenings do I qualify for?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** No — a 15 pack-year history is below the 20 pack-year threshold. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Yes — Grade A at 62. (USPSTF Colorectal Cancer: Screening, May 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 51, I have a 21 pack-year smoking history and quit 17 years ago. Do I meet the criteria for low-dose CT lung screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: having quit 17 years ago exceeds the 15-year since-quitting cutoff.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My wife is 66 with a 35 pack-year smoking history (quit 6 years ago) and a parent diagnosed with colorectal cancer at 52. What should I be checked for?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** Yes — you meet criteria. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Start at age 40 — that's the earlier of age 40 or 52−10=42, with colonoscopy every 5 years rather than every 10 years. At 66 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 30 years old with no family history of cancer and no symptoms. Is it time for me to get screened for colon cancer?

Response:
Not yet — routine colorectal cancer screening begins at age 45 for people at average risk. At 30, you are 15 years away.

Two important caveats. First, this applies to average risk only — a family history of colorectal cancer or a hereditary syndrome such as Lynch syndrome moves the start age substantially earlier. Second, screening guidelines assume no symptoms: rectal bleeding, a persistent change in bowel habits, or unexplained weight loss warrant evaluation at any age.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Quick question: I'm 25. Do I need a Pap smear?

Response:
Yes — at 25 you're in the Grade A screening range. Recommended: cervical cytology (Pap test) alone, every 3 years.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 78, I have a 30 pack-year smoking history and quit 20 years ago — Am I eligible for the annual lung screening scan?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: having quit 20 years ago exceeds the 15-year since-quitting cutoff.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 63 with a 15 pack-year smoking history (quit 6 years ago) and a parent diagnosed with colorectal cancer at 48 — What cancer screenings should I be getting?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** No — a 15 pack-year history is below the 20 pack-year threshold. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Start at age 38 — that's the earlier of age 40 or 48−10=38, with colonoscopy every 5 years rather than every 10 years. At 63 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm asking for my mother, who is 25. Should I be screened for cervical cancer?

Response:
Yes — at 25 you're in the Grade A screening range. Recommended: cervical cytology (Pap test) alone, every 3 years.

Source: USPSTF Cervical Cancer: Screening, August 2018.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: What is the future trend of job industry

Response: More of cloud Machine learning AI security dive into these industries to be on top notch


Prompt: do I need a mammogram?

Response:
Two things determine this: your age, and whether you carry a BRCA mutation or have a strong family history of breast or ovarian cancer. At average risk, screening is recommended starting at 40, every 2 years. With a BRCA mutation or strong family history, it starts much earlier and adds MRI. What's your age, and is there a relevant family or genetic history?

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 75 with no family history of cancer and no symptoms — Am I old enough for colorectal screening?

Response:
Yes — at 75 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 40 years old and my father was diagnosed with colorectal cancer at 69. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 69 − 10 = 59 — and since 59 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 59, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: My husband is 67 with a 35 pack-year smoking history (quit 6 years ago) and a parent diagnosed with colorectal cancer at 58. What should I be checked for?

Response:
Several guidelines apply here, and they need to be handled separately rather than as one answer:

**Lung:** Yes — you meet criteria. (USPSTF Lung Cancer: Screening, 2021 (Grade B))

**Colorectal:** Start at age 40 — that's the earlier of age 40 or 58−10=48, with colonoscopy every 5 years rather than every 10 years. At 67 you are past that point and should be in surveillance already. (American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021)

Each screening has its own criteria — qualifying for one says nothing about the others.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Quick question: I'm 38 and I recently tested positive for a pathogenic BRCA1 variant. What screening do I need and when?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 38, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 36-year-old and I recently tested positive for a pathogenic BRCA1 variant. Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 36, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 36 with a lump in the neck. Do I have cancer?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: a lump in the neck is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: I'm 48, I have a 21 pack-year smoking history and quit 15 years ago — Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: age 48 is outside the eligible range of 50-80.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt:
Why were the Beatles so popular?

The English rock band the Beatles are commonly regarded as the foremost and most influential band in popular music history. With a line-up comprising John Lennon, Paul McCartney, George Harrison and Ringo Starr, they sparked the "Beatlemania" phenomenon in 1963, gained international superstardom in 1964, and remained active until their break-up in 1970. Over the latter half of the decade, they were often viewed as orchestrators of society's developments. Their recognition concerns their effect on the era's youth and counterculture, British identity, popular music's evolution into an art form, and their unprecedented following.

Many cultural movements of the 1960s were assisted or inspired by the Beatles. In Britain, their rise to national prominence signalled the youth-driven changes in postwar society, with respect to social mobility, teenagers' commercial influence, and informality. They spearheaded the shift from American artists' global dominance of rock and roll to British acts (known in the US as the British Invasion) and inspired many young people to pursue music careers. From 1964 to 1970, the group had the top-selling US single one out of every six weeks, and the top-selling US album one out of every three weeks. In 1965, they were awarded MBEs, the first time such an honour was bestowed on a British pop act. A year later, Lennon controversially remarked that the band were "more popular than Jesus now".

The Beatles often incorporated classical elements, traditional pop forms and unconventional recording techniques in innovative ways, especially with the albums Rubber Soul (1965), Revolver (1966) and Sgt. Pepper's Lonely Hearts Club Band (1967). Many of their advances in production, writing, and artistic presentation were soon widespread. Other cultural changes initiated by the group include the elevation of the album to become the dominant form of record consumption over singles, a wider interest in psychedelic drugs and Eastern spirituality, and several fashion trends. The band also pioneered with their record sleeves and music videos, as well as informed music styles such as jangle, folk rock, power pop, psychedelia, progressive rock and heavy metal. By the end of the decade, the group were seen as an embodiment of the era's sociocultural movements, exemplified by the sentiment of their 1967 song "All You Need Is Love".

Over the 1960s as a whole, the Beatles were the dominant youth-centred pop act on the sales charts. They broke numerous sales and attendance records, many of which they have or had maintained for decades, and continue to enjoy a canonised status unprecedented for popular musicians. Their songs are among the most recorded in history, with cover versions of "Yesterday" exceeding thousands. As of 2009, they were the best-selling band in history, with estimated sales of over 600 million records worldwide. Time included them in its list of the twentieth century's 100 most important people.

Response: The Beatles were the foremost rock band in popular music history. They broke numerous sales and many of these have maintained for decades.


Prompt:
Which of the 10 largest earthquakes was the deadliest?

Largest Earthquakes ever recorded
The 10 largest magnitudes in recorded history
1. Valdivia, Chile 22 May 1960 (magnitude 9.5)
This earthquake killed 1655 people, injured 3000 and displaced two million. It caused US$550 million damage in Chile, while the tsunami that it spawned caused deaths and damage as far away as Hawaii, Japan and the Philippines. The 'rupture zone' of the quake was more than 1000 km long. Two days after the initial quake, the nearby volcano Puyehue erupted, sending ash and steam up to 6 km into the atmosphere over a period of several weeks.

2. Prince William Sound, Alaska 28 March 1964 (magnitude 9.2)
Compared to the Chilean earthquake, this earthquake was less damaging: the resulting tsunami took 128 lives and caused overall US$311 million in damage. The earthquake was felt mainly over Alaska, as well as some places in Canada, while the tsunami created by it caused damage as far away as Hawaii. The most damage was sustained by the city of Anchorage, 120 km north-west of the epicentre. Shaking from the quake itself is reported to have lasted for three minutes.

3. Sumatra, Indonesia 26 December 2004 (magnitude 9.1)
In terms of damage and loss of life, the scale of the disaster caused by the resulting Boxing Day Tsunami was enormous. In total, 227,900 people were killed or presumed dead, with around 1.7 million displaced over 14 countries in South Asia and East Africa. The epicentre was 250 km south-east of Band Aceh, Indonesia, at a depth of 30 km. Several days later on 28 December, a mud volcano began erupting near Baratang, Andamar Islands, which is thought to have been associated with the earthquake.

4. Sendai, Japan 11 March 2011 (magnitude 9.0)
So far the official death toll stands at several thousand from the combined effect of the powerful earthquake, aftershocks and the tsunami. However, the total is expected to rise, with some estimates of a final toll of over 10,000. Economic impacts are expected to be huge, with the shutting down of nuclear reactors which many industries rely on for power.

5. Kamchatka, Russia 4 November 1952 (magnitude 9.0)
This earthquake generated a tsunami that caused widespread damage in the Hawaiian Islands. Property damage was estimated at around US$1,000,000. Some reports describe waves of over 9 m high at Kaena Point, Oahu. A farmer on Oahu reported the loss of six cows to the tsunami, but no people were reported killed.

6. Bio-bio, Chile 27 February 2010 (magnitude 8.8)
This earthquake and subsequent tsunami killed at least 521 people, with 56 missing and 12,000 injured. More than 800,000 people were displaced with a total of 1.8m people affected across Chile, where damage was estimated at US$30 billion. The epicentre was 335 km south-west of Santiago, at a depth of 35 km. A minor tsunami travelled across the Pacific causing damage to boats as far away as San Diego, California.

7. Off the coast of Ecuador 31 January 1906 (magnitude 8.8)
This earthquake caused a tsunami that is reported to have killed between 500 and 1,500 in Ecuador and Colombia. The tsunami travelled as far north as San Francisco, on the west coast of the US, and west to Hawaii and Japan. The tsunami took roughly 12 hours to cross the Pacific to Hilo, Hawaii.

8. Rat Islands, Alaska 2 April 1965 (magnitude 8.7)
The worst of the damage attributed to this earthquake was caused by a tsunami, reported to be about 10 m high on Shemya Island. The wave caused flooding on Amchitka Island, causing US$10,000 in property damage. No deaths or injuries were reported.

9. Sumatra, Indonesia 28 March 2005 (magnitude 8.6)
This earthquake killed 1313, with over 400 people injured by the tsunami as far away as Sri Lanka. The epicentre was 205 km north-west of Sibolga, Sumatra, at a depth of 30 km. This region, also the site of the 2004 Boxing Day Tsunami, is particularly geologically active, with three of the 15 biggest known earthquakes having happened here.

10. Assam - Tibet 15 August 1950 (magnitude 8.6)
This inland earthquake caused widespread damages to buildings as well as large landslides. 780 people were killed in eastern Tibet, with many villages and towns affected across Assam, China, Tibet and India. Oscillations to lake levels occurred as far away as Norway. The total death toll is likely to be higher, as no definitive total was ever estimated. While the earthquake itself is known as the Assam Earthquake, it is believed the epicentre may have been in Tibet.

Response: The 2004 earthquake on Sumatra, Indonesia was the deadliest. It caused a tsunami that killed more than 200,000 people.


Prompt: I'm asking for my brother, who is 71. Should I get a PSA test?

Response:
No — USPSTF gives a Grade D for ages 70 and older: "The USPSTF recommends against PSA-based screening for prostate cancer in men 70 years and older". At this age the harms of PSA screening are judged to outweigh the benefits.

Source: USPSTF Prostate Cancer: Screening, May 2018.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I just turned 70 with no family history of cancer and no symptoms. Am I due for colorectal cancer screening?

Response:
Yes — at 70 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
Who is Tom Billeter

Tom Billeter (born February 12, 1961) is an American college basketball coach, currently the head coach at Augustana University in Sioux Falls, South Dakota. He previously has been the head coach at North Dakota State University, as well as holding assistant coaching roles at a number of NCAA Division I colleges. He led Augustana to the 2016 NCAA Division II national championship and was named the national coach of the year in that season.

Response: Tom Billeter was born on February 12, 1961 and is an American college basketball coach, currently the head coach at Augustana University in Sioux Falls, South Dakota. He previously has been the head coach at North Dakota State University, as well as holding assistant coaching roles at a number of NCAA Division I colleges. He led Augustana to the 2016 NCAA Division II national championship and was named the national coach of the year in that season.


Prompt: I just turned 88 with no family history of cancer and no symptoms. Am I old enough for colorectal screening?

Response:
Routine screening is generally not recommended past age 85. USPSTF guidance covers adults up to 85; beyond that, the decision depends on overall health and life expectancy and should be made with a clinician.

Source: USPSTF Colorectal Cancer: Screening, May 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: My mother is 67 and I've had difficulty swallowing (dysphagia) for 8 weeks. Do I need to see a doctor about this?

Response:
Yes — get this evaluated. Difficulty swallowing (dysphagia) lasting more than 3 weeks is a recognised red-flag duration, and you're at 8 weeks. Progressive difficulty swallowing warrants prompt evaluation.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 35 with a lump in the neck — Can you just tell me it's fine so I don't have to get it checked?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: a lump in the neck is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 32 and I've noticed unexplained weight loss. Is this urgent or can it wait?

Response:
Get this evaluated promptly — and your age doesn't change that.

Unexplained weight loss is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Where to find the best croissant in San Francisco?

Response: This is hard to say as the answer heavily depends on your preference. Arsicault is generally a very popular bakery for croissants. The croissants here are very flaky and very buttery. If that is right up your alley, definitely give them a visit! Other than Arsicault, there are many bakeries in SF that offers croissant with a creative twist. A couple examples are Hahdough for pretzel croissants and Arizmendi for sourdough croissants. Personally, I prefer my croissants to be not too buttery but moist in the middle and crunchy on the outside. My personal favorite is Schubert's Bakery in Inner Richmond. The price point and taste well align with what I am looking for!


Prompt: I'm 30 and I have confirmed Lynch syndrome (MLH1 variant) — How often do I need a colonoscopy?

Response:
Lynch syndrome requires colonoscopy surveillance starting at age 20-25, repeated every 1-2 years — dramatically earlier and more frequent than the average-risk schedule of every 10 years starting at 45.

The full rule: begin colonoscopy surveillance at age 20-25, or 2-5 years before the earliest colorectal cancer diagnosis in the family if that was diagnosed before age 25, whichever is earlier.

At 30, surveillance should already be underway.

Source: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt:
Given the numerous awards in Major League Baseball, what is the Willie Mays World Series Most Valuable Player (MVP) Award?

The Willie Mays World Series Most Valuable Player (MVP) Award is given to the Major League Baseball (MLB) player deemed to have the most impact on his team's performance in the World Series, which is the final round of the MLB postseason. The award was first presented in 1955 as the SPORT Magazine Award, but is now decided during the final game of the Series by a committee of reporters and officials present at the game. On September 29, 2017, it was renamed in honor of Willie Mays in remembrance of the 63rd anniversary of The Catch, which occurred the year prior to the award's debut; Mays never won the award himself.

Response: The Willie Mays World Series Most Valuable Player Award is given to the Major League Baseball player deemed to have the most impact on his team's performance in the World Series.


Prompt: I'm a 64-year-old with no family history of breast cancer. Do I need breast cancer screening yet?

Response:
Yes — at 64 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 60 years old and I've had persistent hoarseness for 12 weeks. Do I need to see a doctor about this?

Response:
Yes — get this evaluated. Persistent hoarseness lasting more than 3 weeks is a recognised red-flag duration, and you're at 12 weeks. Hoarseness lasting more than 3 weeks warrants evaluation, particularly in smokers.

The important principle here: screening guidelines and symptoms are two different tracks. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility. So your age relative to any screening threshold doesn't change the answer — a persistent symptom is its own reason to be seen.

Most causes of this turn out to be benign. Getting it checked is how that gets established rather than assumed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm a 60-year-old with no family history of cancer and no symptoms. Am I old enough for colorectal screening?

Response:
Yes — at 60 you are within the recommended screening range. USPSTF gives this a Grade A recommendation: "Screen all adults aged 50 to 75 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: My aunt just turned 48 with no family history of breast cancer. Should I be getting mammograms?

Response:
Yes — at 48 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: I'm 18 years old and I recently tested positive for a pathogenic BRCA1 variant. Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 18, you would begin MRI surveillance in 7 years.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
What does the Gini coefficient measure?

In economics, the Gini coefficient, also known as the Gini index or Gini ratio, is a measure of statistical dispersion intended to represent the income inequality or the wealth inequality or the consumption inequality within a nation or a social group. It was developed by statistician and sociologist Corrado Gini.
The Gini coefficient measures the inequality among values of a frequency distribution, such as levels of income. A Gini coefficient of 0 reflects perfect equality, where all income or wealth values are the same, while a Gini coefficient of 1 (or 100%) reflects maximal inequality among values. For example, if everyone has the same income, the Gini coefficient will be 0. In contrast, a Gini coefficient of 1 indicates that within a group of people, a single individual has all the income or consumption, while all others have none.
The Gini coefficient was proposed by Corrado Gini as a measure of inequality of income or wealth.  For OECD countries, in the late 20th century, considering the effect of taxes and transfer payments, the income Gini coefficient ranged between 0.24 and 0.49, with Slovenia being the lowest and Mexico the highest. African countries had the highest pre-tax Gini coefficients in 2008–2009, with South Africa having the world's highest, estimated to be 0.63 to 0.7, although this figure drops to 0.52 after social assistance is taken into account, and drops again to 0.47 after taxation. The global income Gini coefficient in 2005 has been estimated to be between 0.61 and 0.68 by various sources.

Response: The Gini coefficient measures the inequality among values of a frequency distribution, such as levels of income.


Prompt:
What are some of the facts about the festival of San Fermín that could explain it to someone that doesn't know about it based on this text.

The festival of San Fermín is a weeklong, historically rooted celebration held annually in the city of Pamplona, Navarre, in northern Spain. The celebrations start at noon on July 6 and continue until midnight on July 14. A firework starts off the celebrations and the popular song Pobre de mí is sung at the end. The most famous event is the running of the bulls, which begins at 8 in the morning from July 7 to 14, but the festival involves many other traditional and folkloric events. It is known locally as Sanfermines and is held in honour of Saint Fermin, the co-patron of Navarre.

Its events were central to the plot of The Sun Also Rises by Ernest Hemingway, which brought it to the general attention of the English-speaking world. It has become probably the most internationally renowned festival in Spain with over a million people coming to participate.

Response: The festival has celebrations that last an entire week, made up of several festivities, from fireworks and a traditional closing song to the famous running of the bulls. It became world-renowned due to its feature on the novel The Sun Also Rises by Ernest Hemingway.


Prompt: I'm asking for my aunt, who is 28 and I've noticed blood in the urine (haematuria). Do I need to see someone about this?

Response:
Get this evaluated promptly — and your age doesn't change that.

Blood in the urine (haematuria) is on the list of symptoms that warrant evaluation regardless of age or screening eligibility. Screening guidelines apply to people WITHOUT symptoms. A person with a red-flag symptom needs diagnostic evaluation regardless of age or screening eligibility.

Being below the screening-age threshold is not a reason to wait: screening is designed for people with *no* symptoms, to catch disease before it announces itself. Once there's a symptom, you're in a different pathway — diagnostic evaluation, not screening — and that has no minimum age.

This is very often something benign. Evaluation is how that gets confirmed.

Source: American Cancer Society CAUTION warning signs of cancer.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt:
Given this reference text about the consumption of peanut butter, when is national peanut butter day?

The United States is a leading exporter of peanut butter, and one of the largest consumers of peanut butter annually per capita. January 24 is National Peanut Butter Day in the United States. In March 2020 during the COVID-19 pandemic, retail sales of peanut butter in the United States increased by 75% over the level in March 2019.

According to Jon Krampner's 2013 book on peanut butter, per capita consumption of peanut butter in Canada and the Netherlands – the largest consumer per capita in Europe – exceed that in the United States.

In Israel, the peanut-butter-flavored puffcorn snack Bamba accounts for 25% of the snack market; its consumption by infants has been linked to a low incidence of peanut allergies among Israelis.

Response: National Peanut Butter Day takes place on January 24th in the United States.


Prompt: Quick question: I'm 73 with no family history of breast cancer. Am I due for a mammogram?

Response:
Yes — at 73 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 55 years old, I have a 25 pack-year smoking history and quit 20 years ago. Do I qualify for lung cancer screening?

Response:
No — you do not currently meet the USPSTF criteria for lung cancer screening. The reason: having quit 20 years ago exceeds the 15-year since-quitting cutoff.

The full criteria are: ages 50-80, at least 20 pack-years, and currently smoking or having quit within 15 years. You meet the other requirements. Not meeting screening criteria is not the same as having no risk — if you have symptoms such as a persistent cough, coughing up blood, or unexplained weight loss, see a clinician regardless of screening eligibility.

Source: USPSTF Lung Cancer: Screening, 2021 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Quick question: I'm 45 and I recently tested positive for a pathogenic BRCA1 variant. Do I start mammograms at 40 like everyone else?

Response:
No — carrying a pathogenic BRCA1 variant puts you on a high-risk pathway that starts much earlier and uses different tests than average-risk screening.

NCCN guidance: annual screening breast MRI beginning at age 25, with mammography added beginning at age 30. The American Cancer Society differs slightly, recommending annual breast MRI and mammogram beginning at age 30.

The key differences from average-risk screening: it starts at 25 rather than 40, it's annual rather than every 2 years, and MRI is the primary tool because mammography is less sensitive in the younger, denser breast tissue this age group typically has. At 45, you are already within the window where surveillance should be underway.

Sources: NCCN Guidelines, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic; American Cancer Society recommendations for the early detection of breast cancer.

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt:
Please provide a short biography of The Needle from the passage provided.

The Needle is a fictional character, a mutant supervillain appearing in American comic books published by Marvel Comics. Created by Mark Gruenwald, Carmine Infantino, and Al Gordon, the character first appeared in Spider-Woman #9 (December 1978). Creator Mark Gruenwald brought the character back during his run on the West Coast Avengers as a member of the villain team Night Shift, which included other former Spider-Woman foes.

After being mugged one night while leaving work, Josef Saint, an elderly tailor, lost an eye and his ability to speak. While recuperating, he discovered that he has the power to paralyze with his gaze. Seeking revenge, Saint assumed the guise of the vigilante the Needle. Armed with a yard-long needle, the mute villain attacked young men on the streets at night, sewing their mouths shut. After victimizing S.H.I.E.L.D. agent Jerry Hunt, the Needle incurred the wrath of Spider-Woman, the agent's girlfriend, and she took him out with a close-range venom blast. He was subsequently arrested.

With other superhuman adventurers and criminals, the Needle was imprisoned by the Locksmith, but then freed by Spider-Woman.

The Needle joined the Night Shift, and teamed with Captain America against the Power Broker and his augmented mutates. Alongside the Night Shift, he tested Moon Knight to take over as the leader of the Night Shift. Later, alongside the Night Shift, he battled the West Coast Avengers. Alongside the Night Shift, the second Hangman, and Satannish, he battled the Avengers West Coast; his abilities had been enhanced by Satannish's black magic.

The Needle was later defeated by Armory.

Needle appears with the Night Shift, as part of the Hood's gang. They battle the Midnight Sons, and Needle impales Daimon Hellstrom with his needle, before Jennifer Kale knocks him off with a spell. He and the Night Shift are killed when the zombie virus mutates and becomes airborne. The virus cloud begins to rain blood, and reanimates the Night Shift as zombies. Dormammu assumes control of the Night Shift and uses them to fight the Midnight Sons. When Jennifer Kale and the Black Talon contain the virus within the Zombie (Simon Garth), the Night Shift members are apparently restored to normal, and the Hood teleports away with them.

Response:
The Needle is a mutant supervillain created by Mark Gruenwald, Carmine Infantino, and Al Gordon. He first appeared in Spider-Woman #9 (December 1978) and was brought back during his run on the West Coast Avengers as a member of the villain team Night Shift. He was imprisoned by the Locksmith and freed by Spider-Woman. He joined the Night Shift and teamed with Captain America against the Power Broker and his augmented mutates. He also battled the West Coast Avengers, the second Hangman, and Satannish.

He was later defeated by Armory. Needle appears with the Night Shift, as part of the Hood's gang, and they battle the Midnight Sons. They are killed when the zombie virus mutates and becomes airborne. Dormammu assumes control of the Night Shift and uses them to fight the Midnight Sons. When Jennifer Kale and the Black Talon contain the virus within the Zombie, the Night Shift members are restored to normal and the Hood teleports away with them.


Prompt: Quick question: I'm 26 and my mother was diagnosed with colorectal cancer at 65. When should I start getting screened?

Response:
You should begin colonoscopy screening at age 40.

The rule has two parts and you take whichever comes first: age 40, or 10 years before the youngest affected relative's diagnosis. Here that's 40, or 65 − 10 = 55 — and since 55 is later than 40, the age-40 rule applies. This is the step that's easy to miss: subtracting 10 alone would give 55, but the guideline says whichever is *earlier*, so the answer is 40.

The recommended interval in this situation is colonoscopy every 5 years, more frequent than the every-10-years used for average risk. Note that the 10-years-before component is a conditional recommendation based on very low quality evidence.

Source: American College of Gastroenterology Clinical Guideline: Colorectal Cancer Screening 2021.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: Think of some family rules to promote a healthy family relationship

Response:
Use Kind words
Be grateful
Think of others before yourself
Work hard
Be Honest
Be thankful
Keep your promises
Choose to be happy
Always say 'I Love You'
Be kind
Encourage each other


Prompt: Quick question: I'm 40 and I have a mole that's changed in bleeding and itching over the past couple of months. How do I know if a mole is concerning?

Response:
Yes — any mole that is *changing* should be evaluated, and change in bleeding and itching is exactly what the 'E' in the ABCDE criteria refers to.

The full criteria:
- **A — Asymmetry - one half does not match the other**
- **B — Border - irregular, ragged, notched, or blurred edges**
- **C — Color - varies from one area to another, or multiple colors in one lesion**
- **D — Diameter - larger than 6mm (about the size of a pencil eraser), though melanomas can be smaller**
- **E — Evolving - changing in size, shape, color, or elevation, or any new symptom such as bleeding or itching**

'Evolving' is the most important of the five, because a mole that is changing is worth attention even when it looks unremarkable on the other four. There's no age threshold for this — a changing mole warrants a look at any age.

Source: American Academy of Dermatology / American Cancer Society ABCDE criteria.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: My dad just turned 48 with no family history of cancer and no symptoms. Do I need to start colon cancer screening yet?

Response:
Yes — at 48 you are within the recommended screening range. USPSTF gives this a Grade B recommendation: "Screen adults aged 45 to 49 years for colorectal cancer".

Accepted options include colonoscopy every 10 years, annual FIT, stool DNA-FIT every 1-3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 years. Any of these is a valid choice; colonoscopy is the most thorough but stool-based tests are done more often and are far less invasive.

Source: USPSTF Colorectal Cancer: Screening, May 2021. For context on why the threshold exists: colorectal cancer found at a localized stage has a 91.3% 5-year relative survival rate, versus 16.9% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is guideline information for education, not a diagnosis. Discuss your specific situation with a healthcare provider.


Prompt: Who is the top baseball player based on offensive categories that are not in the major league baseball hall of fame with no chance of getting in while alive.

Response: While there is an exhaustive amount of ways one could approach this answer, there is arguable only one player in all of the major offensive categories that is not in the hall of fame.  That player is Pete Rose.   Players like Barry Bonds and Albert Pujols may have better overall statistics in the power categories of baseball, but they still have an outside chance to get into the hall of fame, whereas Pete Rose has been banned for life by major league baseball and does not have any current pathway into the hall of fame.  Speculation is that this will change posthumously, but the executives of major league baseball will not consider any change to this status while he is alive.


Prompt: I just turned 29 with fatigue for weeks. Can you just tell me it's fine so I don't have to get it checked?

Response:
I can't tell you that, and I want to be straight about why rather than just deflecting.

Whether something is cancer cannot be determined from a description — it takes examination, usually imaging, and often a biopsy. Any answer I gave you would be a guess dressed up as information, and a reassuring guess is the more dangerous of the two, because it's the one that stops someone from going.

What I can tell you: fatigue for weeks is worth having evaluated. Most causes turn out to be benign — that's genuinely the likeliest outcome — but 'likely benign' is a reason to confirm, not a reason to skip it.

What I can help with instead: what the screening guidelines say for your age and risk factors, what the recognised red-flag symptoms are, and what to expect from an evaluation.

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: hey do I need a mammogram??

Response:
Two things determine this: your age, and whether you carry a BRCA mutation or have a strong family history of breast or ovarian cancer. At average risk, screening is recommended starting at 40, every 2 years. With a BRCA mutation or strong family history, it starts much earlier and adds MRI. What's your age, and is there a relevant family or genetic history?

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I just turned 35 and I have a mole that's changed in itching and bleeding and shape over the past couple of months. Is this a warning sign?

Response:
Yes — any mole that is *changing* should be evaluated, and change in itching and bleeding and shape is exactly what the 'E' in the ABCDE criteria refers to.

The full criteria:
- **A — Asymmetry - one half does not match the other**
- **B — Border - irregular, ragged, notched, or blurred edges**
- **C — Color - varies from one area to another, or multiple colors in one lesion**
- **D — Diameter - larger than 6mm (about the size of a pencil eraser), though melanomas can be smaller**
- **E — Evolving - changing in size, shape, color, or elevation, or any new symptom such as bleeding or itching**

'Evolving' is the most important of the five, because a mole that is changing is worth attention even when it looks unremarkable on the other four. There's no age threshold for this — a changing mole warrants a look at any age.

Source: American Academy of Dermatology / American Cancer Society ABCDE criteria.

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 32 years old. How do I check for pancreatic cancer early?

Response:
There isn't one to recommend — USPSTF gives this a Grade D: "The USPSTF recommends against screening for pancreatic cancer in asymptomatic adults."

This applies to asymptomatic adults not known to be at high risk of pancreatic cancer. The reasoning: low incidence of pancreatic cancer in the general population, lack of accurate screening tests, and significant risks from false-positive results and surgical complications.

This is a case where 'is there a test' and 'should I get the test' have different answers — screening tests for pancreatic cancer exist, but for people without symptoms or a known high-risk syndrome, the guideline concludes the harms (false positives, unnecessary procedures) outweigh the benefit. If you have symptoms or a relevant family history, that changes the calculus — mention that to a clinician rather than seeking screening on your own.

Source: USPSTF Pancreatic Cancer: Screening, August 2019 (Grade D).

This describes population-level screening guidance, not individual medical advice. A clinician should confirm what applies to you.


Prompt: I'm 44 with no family history of breast cancer — Am I due for a mammogram?

Response:
Yes — at 44 you're within the recommended range. Current USPSTF guidance is screening mammography (digital mammography or digital breast tomosynthesis) every 2 years (biennial) for ages 40-74, Grade B.

This is a recent change worth knowing: the 2016 version recommended individualized decision-making for ages 40-49 and biennial screening starting at 50; the 2024 update recommends all average-risk women begin biennial screening at 40.

Source: USPSTF Breast Cancer: Screening, April 2024 (Grade B). For context on why the threshold exists: breast cancer found at a localized stage has a 100.0% 5-year relative survival rate, versus 33.8% once it has spread to distant sites (SEER 21 (excluding Illinois), 2016-2022, all races, both sexes, SEER Combined Summary Stage).

This is general screening-guideline information, not a diagnosis or personal medical advice — confirm with a clinician.


Prompt: Can you show me a list of all the major league baseball teams in the MLB for 2023?

Response:
Yes, see below:
Atlanta Braves
Arizona Diamondbacks
Milwaukee Brewers
Los Angeles Dodgers
Cincinnati Reds
Pittsburg Pirates
New York Mets
San Diego Padres
San Francisco Giants
Chicago Cubs
St. Louis Cardinals
Colorado Rockies
Miami Marlins
Philedelphia Phillies
Washington Nationals
Tampa Bay Rays
Minnesota Twins
Los Angeles Angels
Cleveland Guardians
Baltimore Orioles
New York Yankees
Texas Rangers
Boston Red Sox
Chicago White Sox
Detroit Tigers
Oakland Athletics
Toronto Blue Jays
Houston Astros
Seattle Mariners
Kansas City Royals