Daily Papers

Long-horizon LLM multi-agent systems face reliability risks invisible to infrastructure monitoring. We propose the ADE Predictive Reliability Framework (ADE-PRF), enabling proactive health trajectory prediction from passive degradation detection. ADE-PRF aggregates 20 heterogeneous signals across five layers into a Trust Margin (TM) metric (39.2-point dynamic range). Triple-method parallel prediction enables 8-hour forecasts: the Exponential method achieves MAE=1.228, Direction Accuracy=76.8%, with 99.65% within +/-10-point tolerance. Production validation spans 380,227 predictions and 280,579 validations across six agent profiles over 15 continuous days, plus seven sandbox-controlled experiments. Key findings include detection of "false prosperity" -- degradation concealed by normal surface metrics -- and immediate TM coupling with ground-truth states upon ADE plugin integration, with 16/20 factors relying on ADE-collected data. Exponential consistently outperforms Kalman. ADE-PRF provides among the earliest reliability quantification with forward-looking warnings for production LLM agents.

Adverse drug events (ADEs) significantly impact clinical research, causing many clinical trial failures. ADE prediction is key for developing safer medications and enhancing patient outcomes. To support this effort, we introduce CT-ADE, a dataset for multilabel predictive modeling of ADEs in monopharmacy treatments. CT-ADE integrates data from 2,497 unique drugs, encompassing 168,984 drug-ADE pairs extracted from clinical trials, annotated with patient and contextual information, and comprehensive ADE concepts standardized across multiple levels of the MedDRA ontology. Preliminary analyses with large language models (LLMs) achieved F1-scores up to 55.90%. Models using patient and contextual information showed F1-score improvements of 21%-38% over models using only chemical structure data. Our results highlight the importance of target population and treatment regimens in the predictive modeling of ADEs, offering greater performance gains than LLM domain specialization and scaling. CT-ADE provides an essential tool for researchers aiming to leverage artificial intelligence and machine learning to enhance patient safety and minimize the impact of ADEs on pharmaceutical research and development. The dataset is publicly accessible at https://github.com/ds4dh/CT-ADE.

Diffusion-based generative processes, formulated as differential equation solving, frequently balance computational speed with sample quality. Our theoretical investigation of ODE- and SDE-based solvers reveals complementary weaknesses: ODE solvers accumulate irreducible gradient error along deterministic trajectories, while SDE methods suffer from amplified discretization errors when the step budget is limited. Building upon this insight, we introduce AdaSDE, a novel single-step SDE solver that aims to unify the efficiency of ODEs with the error resilience of SDEs. Specifically, we introduce a single per-step learnable coefficient, estimated via lightweight distillation, which dynamically regulates the error correction strength to accelerate diffusion sampling. Notably, our framework can be integrated with existing solvers to enhance their capabilities. Extensive experiments demonstrate state-of-the-art performance: at 5 NFE, AdaSDE achieves FID scores of 4.18 on CIFAR-10, 8.05 on FFHQ and 6.96 on LSUN Bedroom. Codes are available in https://github.com/WLU-wry02/AdaSDE.

Best-of-N (BoN) Average Displacement Error (ADE)/ Final Displacement Error (FDE) is the most used metric for evaluating trajectory prediction models. Yet, the BoN does not quantify the whole generated samples, resulting in an incomplete view of the model's prediction quality and performance. We propose a new metric, Average Mahalanobis Distance (AMD) to tackle this issue. AMD is a metric that quantifies how close the whole generated samples are to the ground truth. We also introduce the Average Maximum Eigenvalue (AMV) metric that quantifies the overall spread of the predictions. Our metrics are validated empirically by showing that the ADE/FDE is not sensitive to distribution shifts, giving a biased sense of accuracy, unlike the AMD/AMV metrics. We introduce the usage of Implicit Maximum Likelihood Estimation (IMLE) as a replacement for traditional generative models to train our model, Social-Implicit. IMLE training mechanism aligns with AMD/AMV objective of predicting trajectories that are close to the ground truth with a tight spread. Social-Implicit is a memory efficient deep model with only 5.8K parameters that runs in real time of about 580Hz and achieves competitive results. Interactive demo of the problem can be seen at https://www.abduallahmohamed.com/social-implicit-amdamv-adefde-demo . Code is available at https://github.com/abduallahmohamed/Social-Implicit .

With the rapid advancement of large language models (LLMs), harnesses have become essential infrastructure for deploying agents across a wide range of domains. The fast-evolving harness ecosystem has also made rigorous capability evaluation increasingly important. However, efficiently building an end-to-end, systematic, and comprehensive evaluation pipeline remains a significant challenge. To address this challenge, we introduce A^2E (Agent Auditing Engine), an end-to-end evaluation engine designed for agent harnesses. A^2E leverages our newly proposed Agent Task Protocol (ATP) to enable the rapid integration of evaluation tasks with different harnesses. Through an automatically instrumented Monitor, it captures and generates standardized execution traces during experiments. In the Evaluation stage, A^2E systematically assesses harness capabilities using a suite of multidimensional metrics. Compared with correctness alone, these metrics provide a more fine-grained characterization of differences among harnesses in execution efficiency, tool use, task planning, and error recovery. Experiments conducted with A^2E further reveal that model-harness combinations exhibit substantial performance variation across different types of tasks, and that no single combination consistently outperforms all others across every task. These findings not only demonstrate the necessity of systematic evaluation but also provide useful guidance for the co-evolving of models and harnesses. Our code is available at https://github.com/datamllab/A2E.

The CAD design process includes a number of repetitive steps when creating assemblies. This issue is compounded when engineering whole product lines or design families, as steps like inserting parts common to all variations, such as fasteners and product-integral base parts, get repeated numerous times. This makes creating designs time-, and as a result, cost-intensive. While many CAD software packages have APIs, the effort of creating use-case specific plugins to automate creation of assemblies usually outweighs the benefit. We developed a plugin for the CAD software package "Fusion 360" which tackles this issue. The plugin adds several graphical interfaces to Fusion 360 that allow parts to be annotated with types, subtype hierarchies to be managed, and requests to synthesize assembly programs for assemblies to be posed. The plugin is use-case agnostic and is able to generate arbitrary open kinematic chain structures. We envision engineers working with CAD software being able to make designed parts reusable and automate the generation of different design alternatives as well as whole product lines.

The optimization of the latents and parameters of diffusion models with respect to some differentiable metric defined on the output of the model is a challenging and complex problem. The sampling for diffusion models is done by solving either the probability flow ODE or diffusion SDE wherein a neural network approximates the score function allowing a numerical ODE/SDE solver to be used. However, naive backpropagation techniques are memory intensive, requiring the storage of all intermediate states, and face additional complexity in handling the injected noise from the diffusion term of the diffusion SDE. We propose a novel family of bespoke ODE solvers to the continuous adjoint equations for diffusion models, which we call AdjointDEIS. We exploit the unique construction of diffusion SDEs to further simplify the formulation of the continuous adjoint equations using exponential integrators. Moreover, we provide convergence order guarantees for our bespoke solvers. Significantly, we show that continuous adjoint equations for diffusion SDEs actually simplify to a simple ODE. Lastly, we demonstrate the effectiveness of AdjointDEIS for guided generation with an adversarial attack in the form of the face morphing problem. Our code will be released on our project page https://zblasingame.github.io/AdjointDEIS/