""" Mock Intelligence Service for Hackathon Demo Provides high-quality scientific insights when the K2 API or DB is unavailable. """ import uuid from datetime import datetime from typing import Dict, Any, List class MockIntelligenceService: @staticmethod def get_mock_analysis_result(email: str = "researcher@example.com") -> Dict[str, Any]: return { "request_id": f"demo_{uuid.uuid4().hex[:8]}", "documents_analyzed": 3, "status": "COMPLETED", "confidence_overall": 0.94, "comparative_analysis": { "document_ids": ["doc1", "doc2", "doc3"], "divergences": [ { "variable": "Hydrophobicity Importance", "finding_a": "Critical for binding affinity (Smith et al.)", "finding_b": "Non-significant in large scale trials (Johnson et al.)", "impact": "High - affects compound selection strategy" } ], "contradictions": [ { "topic": "Temperature Sensitivity", "conflict": "Smith claims stability up to 50°C, while Chen reports degradation at 37°C.", "resolution_path": "Requires standardized pH control across both trials." } ], "common_findings": [ "Molecular weight remains the primary predictor of passive diffusion.", "All papers agree on the necessity of high-throughput screening." ] }, "research_gaps": [ { "gap_description": "Interplay between temperature fluctuations and hydrophobicity in non-polar solvents.", "importance_score": 0.89, "related_variables": ["Temperature", "Octanol-water partition coefficient"], "suggested_investigation": "Factorial design experiment spanning 20°C to 60°C." } ], "counter_hypotheses": [ { "hypothesis": "The perceived hydrophobicity importance is an artifact of pH-dependent ionization.", "rationale": "Meta-analysis shows Smith used pH 7.2 while Johnson used pH 7.8.", "potential_bias": "Experimental setup bias", "validation_experiment": "Run parallel assays at tightly controlled pH intervals (7.0, 7.2, 7.4, 7.6, 7.8).", "confidence_against": 0.76 } ], "proposed_protocol": { "title": "Optimized K2-Think Validation Protocol", "hypothesis": "pH-Standardized binding affinity is the true metric of success.", "objective": "Resolve the Smith-Johnson contradiction via pH-swept assay.", "variables": [ {"name": "pH", "type": "independent", "measurement_unit": "pH", "measurement_method": "Digital pH-meter"}, {"name": "Binding Affinity", "type": "dependent", "measurement_unit": "nM", "measurement_method": "Surface Plasmon Resonance (SPR)"} ], "steps": [ {"step_number": 1, "description": "Prepare 5 buffer batches with pH 7.0 to 7.8.", "materials": ["HEPES", "NaCl"], "risk_level": "low"}, {"step_number": 2, "description": "Apply compound library to SPR chips at 37°C.", "materials": ["SPR Chips", "Compounds"], "risk_level": "medium"} ], "estimated_duration_days": 14, "estimated_budget_usd": 12500, "risk_assessment": {"technical_risk": "Medium", "mitigation": "Redundant SPR chips if binding is weak."} }, "strategic_recommendations": [ "Prioritize pH stabilization in all future drug-discovery pipelines.", "Invest in high-resolution SPR equipment to reduce measurement noise." ], "reasoning_trace": [ {"phase": "Ingestion", "step": "Parsing", "description": "Extracted 45 variables from 3 documents.", "timestamp": datetime.now().isoformat()}, {"phase": "Analysis", "step": "Comparison", "description": "Detected 1 major contradiction in hydrophobicity metrics.", "timestamp": datetime.now().isoformat()}, {"phase": "Synthesis", "step": "Strategy", "description": "Generated optimized protocol to resolve conflicts.", "timestamp": datetime.now().isoformat()} ] }