KAU-BioMedLLM / reports /DATA_PROVENANCE.md
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Resolve resource versions (UniProt 2026_02, AlphaFold v6, Ensembl 116) + Llama-3.1 license compliance ('Built with Llama')
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KAUBioMED-LLM Data Provenance

Date prepared: 2026-06-15

This file records sources actually present or used in the HPC project. Unknown versions are explicitly marked as not recorded rather than guessed.

ClinVar Snapshots

ClinVar train snapshot

ClinVar future/test snapshot

ClinVar Tab-Delimited Metadata

variant_summary.txt.gz

submission_summary.txt.gz

Allele Frequency Sources

  • gnomAD: not used in the current score_model feature table.
  • Current model uses ClinVar VCF INFO fields AF_ESP, AF_EXAC, and AF_TGP when present.
  • gnomAD version: not applicable for current results.

UniProt / PubMed Evidence

  • Evidence file: /ddn/data/generic/bbabajan/KAUBioMED_LLM/knowledge/kaubiomed_gene_evidence.jsonl
  • Exists: True
  • Size bytes: 253848
  • Access date: 2026-06-15 (HPC file mtime; queried via rest.uniprot.org/uniprotkb).
  • UniProt release: 2026_02 (released 10-Jun-2026), the release live on the access date. Resolved 2026-06-19 from UniProt relnotes; release was not captured at runtime.
  • Scope: 20-gene evidence panel, not genome-wide.

AlphaFold DB

  • Manifest: /ddn/data/generic/bbabajan/KAUBioMED_LLM/knowledge/alphafold/alphafold_manifest.jsonl
  • Exists: True
  • Size bytes: 12754
  • Access date: 2026-06-15 (HPC file mtime).
  • AlphaFold DB model version: v6 (from structure URLs, e.g. AF-P32245-F1-model_v6.cif). Note: an earlier evidence-builder pass fetched model_v4; final structures were refreshed to v6, which the manifest reflects.

Ensembl VEP REST

  • Mapper script: /ddn/data/generic/bbabajan/KAUBioMED_LLM/pipeline/vep_residue_mapper.py
  • Exists: True
  • Access date: 2026-06-15 (residue-mapping output mtime; rest.ensembl.org/vep/human/region, assembly GRCh38).
  • Ensembl release: 116 (REST API 15.12), the current live release. Resolved 2026-06-19 from rest.ensembl.org/info; release was not captured at runtime.
  • Mapping policy: MANE-preferred, HGVS protein required, UniProt reconciliation required, abstain on mismatch.

Base LLM Snapshots

Qwen2.5-1.5B-Instruct

  • Snapshot path: /ddn/data/generic/bbabajan/KAUBioMED_LLM/models/hf_snapshots/Qwen__Qwen2.5-1.5B-Instruct
  • Exists: True
  • Recorded revision: revision not recorded
  • Base model ID: Qwen/Qwen2.5-1.5B-Instruct
  • License: verify before public release.

Llama-3.1-8B-Instruct

  • Snapshot path: /ddn/data/generic/bbabajan/KAUBioMED_LLM/models/hf_snapshots/meta-llama__Llama-3.1-8B-Instruct
  • Exists: True
  • Recorded revision: revision not recorded
  • Base model ID: meta-llama/Llama-3.1-8B-Instruct
  • License: Meta Llama 3.1 Community License applies to Llama-derived adapter/merged artifacts; verify current license text before public release.

Score Model Feature Boundaries

Manuscript-facing score_model features exclude AlphaMissense, REVEL, CADD, UVPS, KAUBioMED LLM scores, ClinVar clinical-significance text, and ClinVar review-status/review_stars.