pmid stringlengths 2 8 | title stringlengths 21 1.13k | abstract stringlengths 128 6k | doi stringlengths 0 72 |
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30488364 | Improvement of thermotolerance in Lachancea thermotolerans using a bacterial selection pressure. | The use of thermotolerant yeast strains is an important attribute for a cost-effective high temperature biofermentation processes. However, the availability of thermotolerant yeast strains remains a major challenge. Isolation of temperature resistant strains from extreme environments or the improvements of current stra... | 10.1007/s10295-018-2107-4 |
20392248 | Generation of a mouse model with expression of bone morphogenetic protein type II receptor lacking the cytoplasmic domain in osteoblasts. | Different working modes were proposed to explain how bone morphogenetic protein (BMP) type I and II receptors are involved in Smad phosphorylation cascades. In addition, both parathyroid hormone (PTH) and Wnts are also known to regulate phosphorylation of Smads. Here we established a mouse model in which a C-terminal t... | 10.1111/j.1749-6632.2009.05248.x |
26531167 | Potential advantages of the GuideLiner ® catheter: insights from optical coherence tomography. | Optical coherence tomography (OCT) has been reported as promising not only for the evaluation of lesion morphology, but also for better clinical outcomes; however, in some cases with severe vessel tortuosity or angulated bifurcation, it is difficult to advance an intravascular imaging catheter. We report a case in whic... | 10.1007/s12928-015-0365-x |
22652348 | Visualizing interaction effects: a proposal for presentation and interpretation. | Interaction terms are often included in regression models to test whether the impact of one variable on the outcome is modified by another variable. However, the interpretation of these models is often not clear. We propose several graphical presentations and corresponding statistical tests alleviating the interpretati... | 10.1016/j.jclinepi.2012.02.013 |
11456016 | Color Doppler imaging of untreated and irradiated choroidal melanomas. | We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology. CDI was performed on 122 untreated and 76 previously i... | 10.1177/112067210101100208 |
8033946 | Wernicke's encephalopathy induced by hyperemesis gravidarum, associated with bilateral caudate lesions on computed tomography and magnetic resonance imaging. | The case of an 18-year-old woman with Wernicke's encephalopathy induced by hyperemesis gravidarum is reported. She had severe vomiting and received antiemetic therapy and intravenous administration of glucose and low-dose insulin solution without thiamine. She developed coma, nystagmus, ataxia and polyneuropathy. CT an... | 10.1159/000117034 |
11310206 | The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model. | To investigate the application of micro-computed tomography (microCT) for the assessment of density differences and deterioration of three-dimensional architecture of trabecular bone in an experimental rat model for tumor-induced osteolytic defects. Walker carcinosarcoma 256 malignant breast cancer cells (W256) were su... | 10.1007/s002560000287 |
25627305 | [Legionella pneumonia after infliximab in a patient with rheumatoid arthritis]. | The antagonists of tumour necrosis factor (anti-TNF) have been successfully used in several chronic inflammatory diseases such as Rheumatoid Arthritis (RA), but some studies have observed the development of infections by intracellular pathogens in patients using anti-TNF. We report a case of a female patient with previ... | 10.1016/j.rbr.2013.04.008 |
37074245 | Accuracy of 3-dimensional-printed customized transfer tray using a flash-free adhesive system in digital indirect bonding: An in vivo study. | This paper evaluated the accuracy of a computer-aided design and manufacturing indirect bonding technique using a new customized 3D-printed transfer tray and a flash-free adhesive system for orthodontic bonding. This in vivo study analyzed 106 teeth selected from 9 patients undergoing orthodontic treatment. Quantitativ... | 10.1016/j.ajodo.2023.02.017 |
37150105 | In vitro and in vivo antimicrobial activity of self-assembled melittin nanoparticles: A comparative study with melittin peptide. | The aim of the present study was to analyse the efficacy of self-assembled melittin nanoparticles (MelNP) and compare with native melittin peptide (Mel). Self-assembly formation of the melittin was promoted by heating at 90 °C for 50 min followed by cooling at room temperature. SEM micrographs revealed the formation of... | 10.1016/j.colsurfb.2023.113331 |
26432890 | Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. | TANK-binding kinase 1 (TBK1) is a serine/threonine protein kinase that plays a crucial role in innate immunity. Enhanced TBK1 function is associated with autoimmune diseases and cancer, implicating the potential benefit of therapeutically targeting TBK1. In this article, we examined a recently identified TBK1 inhibitor... | 10.4049/jimmunol.1500162 |
17106807 | Soil fungal communities underneath willow canopies on a primary successional glacier forefront: rDNA sequence results can be affected by primer selection and chimeric data. | Soil fungal communities underneath willow canopies that had established on the forefront of a receding glacier were analyzed by cloning the polymerase chain reaction (PCR)-amplified partial small subunit (18S) of the ribosomal (rRNA) genes. Congruence between two sets of fungus-specific primers targeting the same gene ... | 10.1007/s00248-004-0006-x |
6018511 | Information delivery and the sensory evoked potential. | The waveform of evoked responses recorded from human scalp is not determined solely by the physical eliciting stimulus, but also varies as a function of the effective information provided by the stimulus. There is a positive component whose latency is determined by the point in time at which ambiguity is reduced, and w... | 10.1126/science.155.3768.1436 |
21858763 | From the discovery of vascular endothelial growth factor to the introduction of avastin in clinical trials - an interview with Napoleone Ferrara by Domenico Ribatti. | Napoleone Ferrara and his colleagues at Genentech were the first to isolate and clone vascular endothelial growth factor (VEGF) in 1989. His laboratory has investigated many aspects of VEGF biochemistry and molecular biology. In 1993, Ferrara reported that inhibition of VEGF-induced angiogenesis by specific monoclonal ... | 10.1387/ijdb.103216dr |
33805367 | Surgical Management of the Axilla in Clinically Node-Positive Breast Cancer Patients Converting to Clinical Node Negativity through Neoadjuvant Chemotherapy: Current Status, Knowledge Gaps, and Rationale for the EUBREAST-03 AXSANA Study. | In the last two decades, surgical methods for axillary staging in breast cancer patients have become less extensive, and full axillary lymph node dissection (ALND) is confined to selected patients. In initially node-positive patients undergoing neoadjuvant chemotherapy, however, the optimal management remains unclear. ... | 10.3390/cancers13071565 |
30993381 | In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice. | Brain susceptibility to a neurotoxic insult may be increased in a compromised health status, such as metabolic syndrome. Both metabolic syndrome and exposure to trimethyltin (TMT) are known to promote neurodegeneration. In combination the two factors may elicit additive or compensatory/regulatory mechanisms. Combined e... | 10.1007/s00204-019-02455-0 |
11928669 | [Occupational exposure to chemicals in the manufacture of rubber tires]. | The work environment of the rubber industry company, producing various types of tires, was assessed and the workers of the plant were included in a cohort study of mortality. Concentrations of twenty chemical substances at 137 workposts were measured by employees of the plant laboratory and the sanitary and epidemiolog... | |
987076 | Regulation of female sexual behavior in the golden hamster: behavioral effects of mating and ovarian hormones. | In the female hamster, sexual receptivity was abbreviated following copulation. Short-term effects of mating, lasting approximately 24-48 hr, were observed in females mated in either estradiol- or estradiol-and-progesterone-induced estrus. Long-term effects of copulation, of 9 days or more in duration, were apparent on... | 10.1037/h0077274 |
19534665 | Natural killer cell receptors in human immunodeficiency virus infection: pathways to protection or doors to disappointment? | In the absence of effective treatment, infection with the human immunodeficiency virus (HIV) ultimately leads to the acquired immune deficiency syndrome (AIDS). Many attempts have been made to prevent and attenuate HIV infection. While antiretroviral therapies for infected individuals have had great success, preventati... | 10.2174/157016209789346273 |
32251560 | [Laparoscopic orchiopexy for inguinal palpable cryptorchidism]. | To investigate the feasibility and advantages of laparoscopic orchiopexy in the treatment of inguinal palpable cryptorchidism. This study included 773 cases of inguinal palpable cryptorchidism with 869 undescended testes, 218 on the left, 459 on the right and 96 bilaterally. The patients were aged 6 months to 8 years, ... | |
18266332 | An organic/Si nanowire hybrid field configurable transistor. | We report a field configurable transistor (FCT) fabricated on a Si nanowire FET platform by integrating a thin film of conjugated polymer poly[2-methoxy-5-(2'-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) and an ionic conductive layer (RbAg4I5) into the gate. The FCT can be precisely configured to desired nonvolatile ... | 10.1021/nl073112y |
8135784 | Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT. | The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites. We examined whether NF(P), a nuclear factor specific for the ... | 10.1006/bbrc.1994.1248 |
33233149 | Conidial heat resistance of various strains of the food spoilage fungus Paecilomyces variotii correlates with mean spore size, spore shape and size distribution. | Contamination by spores is often the cause of fungal food spoilage. Some distinct strains of the food spoilage fungus Paecilomyces variotii are able to produce airborne conidia that are more heat-resistant than similar species. These ellipsoid asexual spores can vary in size between strains, but also within strains. He... | 10.1016/j.foodres.2020.109514 |
38825766 | Humanistic burden of haemophilia A without inhibitors: A cross-sectional analysis of the HemoLIFE study. | To evaluate the impact of haemophilia A without inhibitors on humanistic outcomes in patients and caregivers. Herein, we report a cross-sectional analysis of the baseline data of persons with haemophilia (PWH) participating in the prospective study HEMOLIFE. These data are part of a prospective, observational, and mult... | 10.1111/hae.15057 |
35725651 | Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate. | Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy, manifesting as muscle weakness accompanied by impaired metabolism of protein and nucleotide. (D)-3-hydroxybut... | 10.1186/s13578-022-00826-2 |
35765994 | Left pulmonary veins draining into persistent left superior caval vein in presence of unroofed coronary sinus. | We report a case of 5-year-old girl with double outlet right ventricle with a rare combination of partial anomalous pulmonary venous drainage into a persistent left superior caval vein in the presence of an unroofed coronary sinus while highlighting its possible embryological origins and therapeutic implications. © 202... | 10.1111/jocs.16733 |
10926041 | Integrating prevention education into the medical school curriculum: the role of departments of family medicine. | Departments of family medicine--including departments of family and community medicine, departments of family and preventive medicine, and departments of family practice-at U. S. medical schools regularly participate in teaching prevention principles to students, using a variety of formats and methods. Required clinica... | 10.1097/00001888-200007001-00008 |
11672584 | Urokinase-type plasminogen activator up-regulates its own expression by endothelial cells and monocytes via the u-PAR pathway. | Signal transduction by urokinase-type plasminogen activator (u-PA) bound to its cell receptor has been well established. In the present study, we found, for the first time to our knowledge, that u-PA promotes its own synthesis by endothelial cells and monocytes. This phenomenon was characterized and shown to involve th... | 10.1016/s0049-3848(01)00322-x |
11359151 | Homologous collagen substances for vocal fold augmentation. | Dysphonia resulting from failure of glottic closure during voicing is a difficult clinical problem. Recently developed homologous collagen compounds may be beneficial in treating this problem. The objectives of this thesis are to: 1) evaluate the potential site(s) of collagen graft placement in the human vocal fold, qu... | 10.1097/00005537-200105000-00001 |
7262172 | Control of antibiotic therapy in paediatric patients. II. Appropriateness of antibiotic choice in selected diseases. | The adequacy of antibiotic choice and the importance of the physician's knowledge of antibiotic use in causing errors in prescribing were investigated. A prospective three-month study was conducted in nine Italian pediatric hospital wards, involving every patient admitted to hospital for otitis, pneumonia or pharyngoto... | 10.1007/BF00607147 |
36477738 | The cribriform morphology impairs Gleason 7 prostate cancer lesion detection on multiparametric magnetic resonance imaging. | Prostate multiparametric magnetic resonance imaging (mpMRI) is a useful tool for the detection of tumor lesions however, some clinically significant lesions are still missed. We determined whether the cribriform pattern has an effect on lesion detection in mpMRI. We reviewed the single-institution database of the patie... | 10.1002/pros.24465 |
9656453 | Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses. | It is desirable to be able to produce either T1 or T2 responses and we have found that, in mice, mannose--coupled antigens stimulated T2 type responses antibodies and CTLs, whereas if oxidized, mannose--coupled antigens stimulated T1 responses little antibody and a potent CTL response. In addition, the cytokine profile... | 10.1016/s0165-2427(98)00094-4 |
22256957 | The "Miserable Minority" following mild traumatic brain injury: who are they and do meta-analyses hide them? | Ruff et al. (1994; Ruff, Camenzuli, & Mueller, 1996) hypothesized that some mild traumatic brain injury (MTBI) patients will suffer chronic symptomatic complaints and impairments, identifying this subgroup as the "miserable minority." However, several meta-analyses of the effects of MTBI have been published (e. g., Roh... | 10.1080/13854046.2011.647085 |
1614380 | Public and private responsibility for financing nursing-home care: the effect of Medicaid asset spend-down. | Data from a nationally representative sample of nursing-home residents at the beginning of 1987 are used to assess the interaction of Medicaid asset spend-down, the distribution of nursing-home days by payment source, and the effect of proposed changes in public financing of nursing-home care. Three out of five nursing... | |
17085827 | The burden of cardiovascular disease in the Indian subcontinent. | Ischaemic heart disease and stroke are among the most common causes of death and disability in the world. The Indian subcontinent (including India, Pakistan, Bangladesh, Sri Lanka, and Nepal) has among the highest rates of cardiovascular disease (CVD) globally. Previous reports have highlighted the high CVD rates among... | |
37056891 | Comparative Study of Intraoperative Fluorescein and Indocyanine Green Videoangiography for Ruptured Cerebral Aneurysms Clipping: A Single Centre Study of 30 Cases. | Aim This study assesses the application of microscope integrated videoangiography techniques in aneurysm clipping surgery using Indocyanine Green and Fluorescein fluorophores and evaluates merits and demerits of each technique. Materials and Methods Total 30 patients of cerebral aneurysmal clipping were included. Stand... | 10.1055/s-0042-1751006 |
19760493 | A classification and meta-analysis of community-based directly observed therapy programs for tuberculosis treatment in developing countries. | In many developing countries, Directly Observed Therapy (DOT) for tuberculosis has been undertaken mainly in the clinic setting. However, clinic-based DOT may create a high patient load in already overburdened health facilities and increase barriers to care by requiring patients to travel to clinic frequently for thera... | 10.1007/s10900-009-9174-4 |
33742770 | A retrospective analysis of actionable pharmacogenetic/genomic biomarker language in FDA labels. | The primary goal of precision medicine is to maximize the benefit-risk relationships for individual patients by delivering the right drug to the right patients at the right dose. To achieve this goal, it has become increasingly important to assess gene-drug interactions (GDIs) in clinical settings. The US Food and Drug... | 10.1111/cts.13000 |
20157009 | Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. | Functional magnetic resonance imaging can demonstrate the functional anatomy of cognitive processes. In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe resections may result in material specific memory impairment, typic... | 10.1093/brain/awq006 |
10335742 | The SF-36 Arthritis-Specific Health Index (ASHI): I. Development and cross-validation of scoring algorithms. | An arthritis-specific health index (ASHI) for the SF-36 Health Survey was developed by studying its responsiveness to changes in clinical indicators of arthritis severity. Longitudinal data from 1,076 patients participating in four placebo-controlled trials were analyzed. All had at least a 6-month history of moderate ... | 10.1097/00005650-199905001-00004 |
35888454 | How Porphyromonas gingivalis Navigate the Map: The Effect of Surface Topography on the Adhesion of Porphyromonas gingivalis on Biomaterials. | The main purpose of this study is to develop an understanding of how Porphyromonas gingivalis responds to subperiosteal implant surface topography. A literature review was drawn from various electronic databases from 2000 to 2021. The two main keywords used were " Porphyromonas gingivalis " and "Surface Topography". We... | 10.3390/ma15144988 |
12814365 | Differential modulation of NMDA-induced calcium transients by arachidonic acid and nitric oxide in cultured hippocampal neurons. | We have examined the effect of arachidonic acid on the transient increases in intracellular Ca2+ evoked by NMDA and AMPA in cultured hippocampal pyramidal cells loaded with Fura-2 AM. Repeated brief pulses of NMDA elicited Ca2+ transients that showed a modest run down. This run down was enhanced if the preparation was ... | 10.1046/j.1460-9568.2003.02671.x |
12424745 | Comparative effect of dietary administration of Lathyrus sativus pulse on behaviour, neurotransmitter receptors and membrane permeability in rats and guinea pigs. | Neurolathyrism, an upper motor neuron disease, has been thought to be caused by long-term dietary consumption of lathyrus pulse, which contains the toxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. Earlier behavioural studies employing oral feeding of lathyrus pulse to animals has been conducted without evaluatin... | 10.1002/jat.878 |
33524301 | Prognosis of Ocular Tuberculosis Following Long-Term Antitubercular Therapy. | Purpose: This study presents clinical features and prognosis after long-term (12-18 months) antitubercular therapy (ATT) in patients with ocular tuberculosis (OTB) in East China, an endemic area of tuberculosis. Methods: This retrospective study reviewed data from OTB patients treated at the Eye and ENT Hospital of Fud... | 10.1089/jop.2020.0100 |
10598967 | AV node ablation and pacemaker implantation after withdrawal of effective rate-control medications for chronic atrial fibrillation: effect on quality of life and exercise performance. | We assess whether AV node ablation and pacemaker implantation after discontinuation of effective rate-control medical therapy for chronic atrial fibrillation had a positive impact on quality of life and exercise performance. To assess the possibility of a placebo effect following pacemaker implantation, the study inclu... | 10.1111/j.1540-8159.1999.tb00383.x |
27248298 | Marriage, violence and HIV: the shifting policy context in Uganda. | The policy environment for vulnerable women in Uganda is rapidly changing, with the aim of introducing more punitive measures for violent offenders and more options for women seeking help. This paper examines HIV-positive women who experienced intimate partner violence in two regions of Uganda prior to the enactment of... | 10.1080/13691058.2016.1184313 |
2096499 | Clinical efficacy of mefloquine in children suffering from chloroquine-resistant Plasmodium falciparum malaria in Nigeria. | One hundred and thirteen children with symptomatic uncomplicated falciparum malaria were treated with either chloroquine 25 mg/kg body weight over 3 d (51 subjects) or mefloquine 25 mg/kg body weight single dose (62 subjects). The cure rate in the chloroquine group was 65% and in the mefloquine group 100%. 14 patients ... | 10.1016/0035-9203(90)90067-o |
17975144 | The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. | We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)-positive breast cancer patients receiving tamoxifen monotherapy. The biological mechanisms linking these genes to estrogen signaling and tamoxifen response in breast cancer remain to be deter... | 10.1158/1078-0432.CCR-07-0310 |
18784478 | Transcranial Doppler ultrasonography: a diagnostic tool of increasing utility. | Since its introduction in 1982, transcranial Doppler ultrasonography has become an important diagnostic and monitoring tool in patients with surgical disease. It has applications in the perioperative period, as well as in the intensive care unit. It is therefore appropriate for the anesthesiologist to maintain an under... | 10.1097/ACO.0b013e32830edc0b |
23728871 | Evidence-based treatment strategies in idiopathic pulmonary fibrosis. | Recently updated guidelines have provided revised recommendations, based on the GRADE criteria, for the diagnosis and pharmacological and non-pharmacological management of patients with idiopathic pulmonary fibrosis (IPF). Cochrane reviews are also a highly respected and reliable source of evidence-based information th... | 10.1183/09059180.00001013 |
25990190 | Impact of an Overnight Internal Medicine Academic Hospitalist Program on Patient Outcomes. | Many academic hospitals have implemented overnight hospitalists to supervise house staff and improve outcomes, but few studies have described the impact of this role. To investigate the effect of an overnight academic hospitalist program on patient-level outcomes. Secondary objectives were to describe the program's rev... | 10.1007/s11606-015-3389-0 |
33348939 | Parry-Romberg syndrome: a mini review. | Parry-Romberg syndrome (PRS) is a rare disorder of uncertain etiology that is characterized by progressive atrophy of the soft and hard tissues of face, typically occurring in the first 2 decades of life. It is more commonly seen in females. The disease progresses slowly with gradual atrophy, frequently associated with... | |
33859481 | Evaluation of Wet Mount and Concentration Techniques of Stool Examination for Intestinal Parasites Identification at Debre Markos Comprehensive Specialized Hospital, Ethiopia. | Intestinal parasitic infection has serious medical and public health impacts in developing countries. Intestinal parasites were under reported via direct wet mount method due to its poor sensitivity. So, the selection of a more sensitive and reliable diagnostic method is essential. The aim of the study was to evaluate ... | 10.2147/IDR.S307683 |
32647601 | An Evaluation of Assistive Technology in Determining Job-Specific Preference for Adults With Autism and Intellectual Disabilities. | The transition to employment can be difficult for adults with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Currently, a limited number of ASD-specific career-planning tools exist within the literature, creating a challenge in terms of accurately identifying jobs that match individual preference... | 10.1007/s40617-019-00380-3 |
7894301 | New techniques of ultrasound and color Doppler in the prospective evaluation of acute renal obstruction. Do they replace the intravenous urogram? | The intravenous urogram has long been the primary imaging modality in assessing acute renal obstruction. Newer ultrasound (US) techniques including pulsed and color Doppler allow the physiology of the urinary system to be interrogated via the resistive indices and ureteral jets. We sought to determine whether these new... | 10.1007/BF00199647 |
27249814 | Acute myocarditis with normal wall motion detected with 2D speckle tracking echocardiography. | SummaryWe present the case of a 26-year-old male with acute tonsillitis who was referred for coronary angiography because of chest pain, elevated cardiac biomarkers, and biphasic T waves. The patient had no cardiovascular risk factors. Echocardiography showed no wall motion abnormalities and no pericardial effusion. 2D... | 10.1530/ERP-16-0013 |
18972868 | [Therapeutic approaches for treatment of Creutzfeldt-Jakob disease]. | A multiplicity of different chemical agents have shown positive effects in vivo in the treatment of prion diseases. However, some properties make implementation in clinical studies difficult, such as toxic effects or missing penetration of the blood-brain barrier. Thus, further studies are concentrating on the developm... | |
26132161 | Comprehensive Glycomics of a Multistep Human Brain Tumor Model Reveals Specific Glycosylation Patterns Related to Malignancy. | Cancer cells frequently express glycans at different levels and/or with fundamentally different structures from those expressed by normal cells, and therefore elucidation and manipulation of these glycosylations may provide a beneficial approach to cancer therapy. However, the relationship between altered glycosylation... | 10.1371/journal.pone.0128300 |
23263110 | Optical performance monitoring for OFDM using low bandwidth coherent receivers. | We propose using low bandwidth coherent receivers for distributed optical performance monitoring. We demonstrate optical signal-to-noise ratio (OSNR) monitoring of both 20-Gb/s single-polarization and 40-Gb/s polarization-multiplexed coherent optical orthogonal frequency-division multiplexing (CO-OFDM) signals with a 0... | 10.1364/OE.20.028724 |
38474331 | Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein. | Fibrosis is characterized by excessive extracellular matrix formation in solid organs, disrupting tissue architecture and function. The Y-box binding protein-1 (YB-1) regulates fibrosis-related genes (e. g., Col1a1, Mmp2, and Tgfβ1 ) and contributes significantly to disease progression. This study aims to identify fibr... | 10.3390/cells13050367 |
28366438 | Measuring joint kinematics of treadmill walking and running: Comparison between an inertial sensor based system and a camera-based system. | Inertial sensor systems are becoming increasingly popular for gait analysis because their use is simple and time efficient. This study aimed to compare joint kinematics measured by the inertial sensor system RehaGait® with those of an optoelectronic system (Vicon®) for treadmill walking and running. Additionally, the t... | 10.1016/j.jbiomech.2017.03.015 |
32602645 | Between a rock and a hard place: adaptive sensing and site-specific dispersal. | Environmental variability can lead to dispersal: why stay put if it is better elsewhere? Without clues about local conditions, the optimal strategy is often to disperse a set fraction of offspring. Many habitats contain environmentally differing sub-habitats. Is it adaptive for individuals to sense in which sub-habitat... | 10.1111/ele.13564 |
31472902 | Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. | Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58 monogenic causes of SRNS have been discovered and majority of known steroid-resistant nephrotic syndrome causing genes are predominantly expressed in glomerular podoc... | 10.1016/j.kint.2019.06.016 |
21818597 | Thoracolumbar imbalance analysis for osteotomy planification using a new method: FBI technique. | Treatment of spine imbalance by posterior osteotomy is a valuable technique. Several surgical techniques have been developed and proposed to redress the vertebral column in harmonious kyphosis in order to recreate correct sagittal alignment. Although surgical techniques proved to be adequate, preoperative planning stil... | 10.1007/s00586-011-1935-y |
37176504 | Cardioselective versus Non-Cardioselective Beta-Blockers and Outcomes in Patients with Atrial Fibrillation and Chronic Obstructive Pulmonary Disease. | Atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) have been independently associated with increased mortality; however, there is no evidence regarding beta-blocker cardioselectivity and long-term outcomes in patients with AF and concurrent COPD. Methods: This post hoc analysis of the MISOAC-AF r... | 10.3390/jcm12093063 |
27987448 | The optimization, kinetics and mechanism of m-cresol degradation via catalytic wet peroxide oxidation with sludge-derived carbon catalyst. | The sludge-derived carbon catalyst modified with 0°C HNO 3 solution was tested in catalytic wet peroxide oxidation of m-cresol (100mgL -1 ) with systematical mathematical models and theoretical calculation for the first time. The reaction conditions were optimized by response surface methodology (RSM) as T=60°C, initia... | 10.1016/j.jhazmat.2016.12.014 |
26074410 | Characterization of Salmonella enterica serovar Typhimurium and Salmonella enterica serovar 4,[5],12:i:- isolates from pigs presenting with diarrhea in Korea. | Between 2011 and 2012, a total of 896 pig fecal samples were collected from nine provinces in Korea, and 50 salmonella enterica susp. enterica serovar Typhimurium (S. Typhimurium) was isolated. The characteristics of the 50 strains were analyzed, and 4 strains were identified as Salmonella enterica subsp. enterica sero... | 10.1292/jvms.15-0151 |
2883284 | Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats. | Bilateral injection of apomorphine (2.5 micrograms) into the substantia nigra zona reticulata of rats reduced both locomotor activity and striatal HVA and DOPAC concentrations. Bilateral injection of dopamine (10 micrograms) did not affect locomotor activity whereas a higher dose of dopamine (50 micrograms) enhanced lo... | 10.1111/j.2042-7158.1987.tb06248.x |
25408859 | Diagnosis and subclassification of acute lymphoblastic leukemia. | Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness that both ALL therap... | 10.4084/MJHID.2014.073 |
21508561 | Ecofriendly decolorisation of Cr-complex dye Acid Black 172 by a newly isolated Pseudomonas sp. strain DY1. | Pseudomonas sp. strain DY1 was newly isolated from soil with rotten wood and identified as a member of the genus Pseudomonas based on 16S rDNA and biochemical tests. Acid Black 172, a water soluble Cr-complex dye, was then selected as a model dye to investigate the decolorisation ability of the strain. It was observed ... | 10.2166/wst.2011.328 |
28251321 | Comparing the effects of peritonsillar infiltration of tramadol before and after the surgery on post-tonsillectomy pain. | The aim of the study was to compare the effects of peritonsillar infiltration of tramadol before and after the surgery on post-tonsillectomy pain. In this double-blinded clinical trial study, 80 children aged 5-12 years old with ASA (American Society of Anesthesiologists) class I or II undergoing tonsillectomy involved... | 10.1007/s00405-017-4477-z |
25295133 | Cost-effectiveness analysis reveals microsurgical varicocele repair is superior to percutaneous embolization in the treatment of male infertility. | Varicoceles are a common cause of male infertility; repair can be accomplished using either surgical or radiological means. We compare the cost-effectiveness of the gold standard, the microsurgical varicocele repair (MV), to the options of a nonmicrosurgical approach (NMV) and percutaneous embolization (PE) to manage v... | 10.5489/cuaj.1873 |
20078655 | Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its "index sorting" function for stem cell research. | To achieve an integrated understanding of the stem cell system of planarians at both the cellular and molecular levels, we developed a new method by combining "fluorescent activated cell sorting (FACS) index sorting" analysis and single-cell reverse transcription-polymerase chain reaction (RT-PCR) to detect the gene ex... | 10.1111/j.1440-169X.2009.01157.x |
10411440 | Should carcinoembryonic antigen be used in the management of patients with colorectal cancer? | The contribution of carcinoembryonic antigen carcinoembryionic antigen for the effective management of colorectal cancer patients remains a controversial issue. The aim of this study is to attempt to get some valid answers to its function in the diagnosis, prognosis, and overall management of colorectal cancer patients... | 10.1007/BF02237104 |
17522237 | Sentinel lymph node biopsy in male patients with early breast cancer. | Mastectomy with axillary dissection is still the most commonly recommended procedure for male breast cancer. The aim of this study was to retrospectively evaluate our experience in 32 male patients with early breast cancer who underwent sentinel lymph node biopsy (SLNB) and axillary dissection only in cases of metastas... | 10.1634/theoncologist.12-5-512 |
34074321 | Thrombosis and bleeding outcomes in the treatment of cerebral venous thrombosis in cancer. | There is a need for clinical outcome data of cerebral venous thrombosis (CVT) in cancer patients. We examined the recanalization, thrombosis recurrence and major bleeding during CVT treatment in a cancer exclusive adult population. We performed a retrospective review of cancer associated CVT identified through an insti... | 10.1186/s12959-021-00292-9 |
38590770 | Cardiac biomarkers and left ventricular systolic function in former very preterm infants and term controls at preschool age. | Due to improvements in perinatal care, survival rates of preterm infants have improved during the last decades. However, these infants remain at risk of developing cardiovascular sequelae later in life. This study aimed to investigate the cardiac biomarkers and left ventricular systolic function in former preterm infan... | 10.3389/fped.2024.1376360 |
12150202 | Doxorubicin directly binds to the cardiac-type ryanodine receptor. | The clinical use of doxorubicin, an antineoplasmic agent, is limited by its extensive cardiotoxicity which is mediated by the mobilization of intracellular Ca2+ from SR. In order to elucidate the mechanism of Ca2+ release, we analyzed the binding sites of doxorubicin on rabbit cardiac SR (sarcoplasmic reticulum). One o... | 10.1016/s0024-3205(02)01524-2 |
28719312 | Molecular Epidemiology of Malaria in Cameroon and Côte d'Ivoire. XXXI. Kelch 13 Propeller Sequences in Plasmodium falciparum Isolates before and after Implementation of Artemisinin-Based Combination Therapy. | Artemisinin-resistant malaria has not been reported from Africa, but resistance can possibly spread from Asia or arise independently in Africa. The emergence of artemisinin resistance in Africa can be monitored by molecular assay of Kelch 13 (K13) propeller sequences. A total of 251 archived DNA samples of Plasmodium f... | 10.4269/ajtmh.16-0889 |
36525295 | A Membrane-Embedded Macromolecular Catalyst with Substrate Selectivity in Live Cells. | Substrate selectivity is one of the most attractive features of natural enzymes from their "bind-to-catalyze" working flow and is thus a goal for the development of synthetic enzyme mimics that mediate abiotic transformations. However, despite the recent success in the preparation of substrate-selective enzyme mimics b... | 10.1021/jacs.2c11168 |
33484303 | The effect of bicipital groove morphology on the stability of the biceps long head tendon. | Long head of biceps tendon (LHBT) instability is an important source of pain and disability for the shoulder. Supraspinatus and subscapularis tendons contribute to the formation of the biceps pulley system, which maintains biceps stability during shoulder movements. The aim of this study is to evaluate the effect of mo... | 10.1007/s00402-021-03760-z |
14657277 | RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. | We have used RNA interference (RNAi) to examine the functional relationship between valosin-containing protein (VCP/p97/Cdc48p/TER94) ATPase and the ubiquitin-proteasome system (UPS) in Drosophila S2 and human HeLa cells. In both cell types, RNAi of VCP (and, to a lesser extent, of certain VCP-interacting proteins) cau... | 10.1242/jcs.00841 |
7049581 | A method for the intraocular injection of micro-volumes in small animal species. | A method has been developed for the intraocular administration of small volumes (0.5-1.5 microliters) in small animal species such as guniea pigs and rats. The method was found to yield reproducible injection volumes and resulted in minimal ocular trauma. The aqueous humor of eyes injected with saline contained normal ... | 10.3109/02713688109001873 |
21292591 | Representing cardiac bidomain bath-loading effects by an augmented monodomain approach: application to complex ventricular models. | Although the cardiac bidomain model has been widely used in the simulation of electrical activation, its relatively computationally expensive nature means that monodomain approaches are generally required for long-duration simulations (for example, investigations of arrhythmia mechanisms). However, the presence of a co... | 10.1109/TBME.2010.2096425 |
24309103 | EpCAM expression in the prostate cancer makes the difference in the response to growth factors. | Epithelial cell adhesion molecule (EpCAM) is expressed in tumors with an epithelial cell of origin, in a heterogeneous manner. Prostate cancer stem-like cells highly express EpCAM. However, little is known about how EpCAM is involved in the ability of cells to adapt to micro-environmental changes in available growth fa... | 10.1016/j.bbrc.2013.11.093 |
21914470 | Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress. | Chronic arsenic exposure causes oxidative stress and mitochondrial dysfunction in the liver and brain. The ideal treatment would be to chelate arsenic and prevent oxidative stress. meso-2,3-Dimercaptosuccinic acid (DMSA) is used to chelate arsenic but its hydrophilicity makes it membrane-impermeative. Conversely, querc... | 10.1016/j.freeradbiomed.2011.08.019 |
38995470 | The potential application of Czenspinskia transversostriata in biological control. | Phytoseiid predatory mites are one of the most important groups of biocontrol agents, commonly used in biological control. The ability to produce these predatory mites economically, at high density on cheap factitious food sources, is a major contributor to their success. Astigmatid mites are the most widely used facti... | 10.1007/s10493-024-00945-0 |
21453946 | Genetic diversity of porcine circovirus type 2 (PCV2) in the Romanian wild boar population. | In this study, we have analyzed 23 PCV2 ORF2 sequences recovered from wild boar population in Romania. The PCV2 sequences were originated from different geographical regions in Romania, and collected between 2008 and 2009 during the classical swine fever virus (CSFV) surveillance campaign. Complete open reading frame 2... | 10.1016/j.rvsc.2011.03.002 |
23724387 | Septic embolism in the intensive care unit. | Septic embolism encompasses a wide range of presentations and clinical considerations. From asymptomatic, incidental finding on advanced imaging to devastating cardiovascular or cerebral events, this important clinico-pathologic entity continues to affect critically ill patients. Septic emboli are challenging because t... | 10.4103/2229-5151.109423 |
36907203 | Music Perception Abilities of the Hearing Amplification System Users. | Recently, the improvement of music perception abilities for emotional stability and high quality of life has become important for the hearing loss group. This study aimed to examine and compare the music perception abilities of the normal hearing (NH) and hearing amplification system (HAS) groups to find the needs and ... | 10.7874/jao.2022.00367 |
8959316 | Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women. | Several epidemiological studies have identified an association between nonsteroidal anti-inflammatory drug (NSAID) use and colorectal cancer risk in women. We examined this association in a population-based case-control study in Wisconsin women. Between 1991 and 1992, 184 women ages 40-74 years with colorectal cancer w... | |
8417938 | Use of maximum expiratory flow-volume curve parameters in the assessment of exercise-induced bronchospasm. | Exercise-induced bronchospasm (EIB) is often inferred from the reduction after exercise in one arbitrarily selected value derived from the maximum expiratory flow-volume (MEFV) curve (eg, FEV1) on a single test; however, patients with symptoms of EIB not meeting these criteria may risk being undiagnosed. To assess the ... | 10.1378/chest.103.1.64 |
29126816 | Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells. | The aim of this study is to investigate the effects of spermine and the passive avoidance learning on hippocampus following transient cerebral ischemia in the chicks. The study is composed of the pure control (CG), sham (SG) and experimental groups (n=20). Experimental groups (ischemia group, IG and ischemia-spermine g... | 10.1016/j.jchemneu.2017.11.006 |
25647891 | Taking a fresh look at Medicaid. | Hospitals should evaluate four approaches to providing high-quality, cost-effective care for Medicaid patients: Continue to focus on strengthening primary care and improving cost efficiency in the current Medicaid market. Develop value-based, risk-sharing contracts with existing Medicaid managed care organizations. Par... | |
36840100 | The Potential of Cover Crops for Weed Management: A Sole Tool or Component of an Integrated Weed Management System? | Cover crops are an important component of integrated weed management programs in annual and perennial cropping systems because of their weed suppressive abilities. They influence weed populations using different mechanisms of plant interaction which can be facilitative or suppressive. However, the question often arises... | 10.3390/plants12040752 |
36702015 | Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma. | The prognostic impact of human papillomavirus (HPV) infection or smoking on oropharyngeal high-grade neuroendocrine carcinoma (HG-NEC) is not established. Retrospective study with patients with oropharyngeal HG-NEC seen at MD Anderson Cancer Center from 1997 to 2020, and previously reported patients with oropharyngeal ... | 10.1016/j.oraloncology.2023.106311 |
1000898 | The radiology of the intrauterine contraceptive device. | Some intrauterine devices are of low radiographic density and require careful technique for their demonstration. The main indications for radiology are to exclude deformity, which reduces the loop's efficiency, perforation of the uterus, or expulsion of the loop. | 10.1016/s0009-9260(76)80124-9 |
24436739 | Innovative intraoperative titanium mesh preparation for safer implantation. | Titanium meshes have been extensively used in craniomaxillofacial surgery. The benefits of these titanium implants include being inert, stable, and radiopaque and having good drainage properties. The titanium mesh is cut to shape and bent before implantation, which may give rise to the cut edges being jagged and sharp.... | 10.1055/s-0032-1329544 |
33436515 | Complementary Roles of Wood-Inhabiting Fungi and Bacteria Facilitate Deadwood Decomposition. | Forests accumulate and store large amounts of carbon (C), and a substantial fraction of this stock is contained in deadwood. This transient pool is subject to decomposition by deadwood-associated organisms, and in this process it contributes to CO 2 emissions. Although fungi and bacteria are known to colonize deadwood,... | 10.1128/mSystems.01078-20 |
39572652 | Evaluation of radiological hazards associated with some Egyptian marble and granite rocks. | The aim of the current study is to evaluate the radioactivity estimate the radiological risk of some granites and marbles rocks and explaining the cause of increased radioactivity in some types of rocks. The radioactivity of some granites and marbles produced in Egypt were determined by using a Germanium detector. Thre... | 10.1038/s41598-024-80298-1 |
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