pdb_code stringlengths 4 4 | release_date stringdate 1991-10-15 00:00:00 2026-01-28 00:00:00 | classification stringclasses 1
value | chains stringlengths 61 5.01k | formula_weight float64 387 271k | symmetry stringclasses 66
values | crystal_structure(a|b|c|alpha|beta|gamma) stringlengths 5 45 | exptl_method stringclasses 6
values | synthesis_comment stringclasses 73
values | authors stringlengths 7 521 ⌀ | publication stringlengths 15 254 | publication_ref(doi|pubmed|csd|issn|astm) stringlengths 4 62 | publication_country stringclasses 9
values | subtitle stringlengths 6 213 | tags stringlengths 9 287 | sequence_related_designs_above_50_bits stringlengths 8 1.39k ⌀ | sequence_related_natural_proteins_above_50_bits stringlengths 8 115k ⌀ | structure_related_designs_above_95_lddt stringlengths 7 1.13k ⌀ | structure_related_natural_above_95_lddt stringclasses 247
values | highest_sequence_related_design stringlengths 7 10 ⌀ | highest_sequence_related_natural_protein stringlengths 8 10 ⌀ | highest_structure_related_design stringlengths 7 18 ⌀ | highest_structure_related_natural_protein stringlengths 7 18 ⌀ | cath_full stringlengths 9 3.45k ⌀ | data_curation_comments stringclasses 3
values |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
4jlr | 2014-02-05 | other | id:H,A;type:N;source:Homo sapiens;length:227;seq_nat:QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSANQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK;seq_unnat:QVTLRESGPALVKPTQTLTLTCTFSGFSLST... | 24,226.361 | C 2 2 21 | 149.159|158.511|116.049|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | B.E. Correia;J.T. Bates;R.J. Loomis;G. Baneyx;C. Carrico;J.G. Jardine;P. Rupert;C. Correnti;O. Kalyuzhniy;V. Vittal;M.J. Connell;E. Stevens;A. Schroeter;M. Chen;S. Macpherson;A.M. Serra;Y. Adachi;M.A. Holmes;Y. Li;R.E. Klevit;B.S. Graham;R.T. Wyatt;D. Baker;R.K. Strong;J.E. Crowe;P.R. Johnson;W.R. Schief | "Proof of principle for epitope-focused vaccine design", Nature, 507, 201-206 | 10.1038/nature12966|24499818|0006|0028-0836|NATUAS | UK | Crystal structure of a designed respiratory syncytial virus immunogen in complex with motavizumab | antibody;specific binding;designed immunogen;immune system;rsv f protein | null | null | null | null | null | null | 4l8i(0.8191000223) | 3lf9(0.7256000042) | 1.20.58.60;1.20.1280.280;1.20.120.400;1.10.10.1740;1.20.58.160;1.20.58.400;1.20.58.1150;1.10.246.120;1.20.1280.130;1.10.150.510;1.20.58.930;1.20.58.1440;1.20.58.1200;1.10.287.750;1.20.1440.60;1.20.58.420;1.20.58.80;1.20.58.220;1.20.1280.20;1.10.340.60;1.20.1280.140;1.20.120.230;1.10.287.3180;1.20.58.340;1.10.10.400;1.2... | null |
4jw2 | 2013-09-25 | other | id:A;type:D;source:synthetic construct;length:109;seq_nat:MRGSHHHHHHTDPEKVEMYIKNLQDDSSVVRKAAAVALGEIGDERAVEPLIKALKDEDQFVRIAAAWALGKIGGERVRAAMEKLAETGTGFARKVAVNYLETHKSLIS;seq_unnat:MRGSHHHHHHTDPEKVEMYIKNLQDDSSVVRKAAAVALGEIGDERAVEPLIKALKDEDQFVRIAAAWALGKIGGERVRAAMEKLAETGTGFARKVAVNYLETHKSLIS|id:B;type:U;source:unknown;length:... | 11,947.639 | P 43 21 2 | 87.760|87.760|77.980|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Guellouz;M. Valerio-Lepiniec;A. Urvoas;A. Chevrel;M. Graille;Z. Fourati-Kammoun;M. Desmadril;H. van Tilbeurgh;P. Minard | "Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)", Plos One, 8, e71512-e71512 | 10.1371/journal.pone.0071512|24014183||1932-6203| | US | Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alpharep) | proteins engineered to bind to various partners;de novo protein/protein binding;alpha-helical proteins;de novo protein-protein binding complex | 4jw3(225);3ltj(400);4zv6(293);6bzx(293);3ltm(371);6veh(284) | 1te4(149) | 3ltj(0.978399992);4zv6(0.9585000277) | null | 3ltj(400) | 1te4(149) | 3ltj(0.978399992) | 2z5k(0.787899971) | 1.25.40.250;1.20.5.420;1.20.970.10;1.25.40.90;1.25.10.10;1.25.40.420;1.25.40.750;1.25.40.40;1.25.40.70;1.25.40.580;1.20.58.1290;1.25.40.1040;1.20.50.20;1.25.40.850;1.25.40.290;1.10.10.2400;1.20.58.80;1.25.40.450;1.25.60.10;1.25.40.10;1.10.1240.70;1.25.40.320;1.10.10.1270;1.25.40.310;1.10.220.10;1.20.58.770;1.25.40.180 | null |
4jw3 | 2013-09-25 | other | id:A,B;type:N;source:Streptomyces malayensis;length:121;seq_nat:AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYWVAQWARVDTGVWAYNPADNSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFAAHHHHHH;seq_unnat:AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYWVAQWARVDTGVWAYNPADNSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFAAHHHHHH|id:C... | 12,196.199 | P 21 21 2 | 118.210|59.210|65.530|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Guellouz;M. Valerio-Lepiniec;A. Urvoas;A. Chevrel;M. Graille;Z. Fourati-Kammoun;M. Desmadril;H. van Tilbeurgh;P. Minard | "Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)", Plos One, 8, e71512-e71512 | 10.1371/journal.pone.0071512|24014183||1932-6203| | US | Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alpharep) | alpha-helical protein;dna binding protein/de novo protein;dna binding protein-de novo protein complex;protein engineered to interact with protein of interest;ncs 3tes24 variant | 3ltj(225);4jw2(225);3ltm(196);4zv6(190);6bzx(190);6veh(168) | 1te4(146) | 3ltj(0.9613999724);4zv6(0.9532999992) | null | 3ltj(225) | 1te4(146) | 3ltj(0.9613999724) | 3w3w(0.747600019) | 1.25.40.290;1.25.40.250;1.20.930.10;1.25.40.40;1.25.40.70;1.10.220.10;1.25.10.10;1.25.40.10;1.10.1240.70 | null |
4jxi | 2013-05-22 | other | id:A,B;type:D;source:synthetic construct;length:424;seq_nat:MGSHMEVNLRMSWWGGNGRHQVTLKALEEFHKQHPNINVKAEYTGWDGHLSRLTTQIAGGTEPDVMQTNWNWLPIFSKDGTGFYNLFSVKEQLDLAQFDPKELQQTTVNGKLNGIPISVTAMIFYFNDATWAKAGLEYPKTWDELLAAGKVFKEKLGDQYYPVVLCAGQTLVLIRSYMTQKYNIPTIDEANKKFAYSPEQWVEFFTMYKTMVDNHVMPSTKYYASIVKSSYYEMKPWINGEWAGTYMWNSTITKYSDNLT... | 48,525.512 | P 21 21 21 | 63.201|90.122|137.349|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Kuzin;M.D. Smith;F. Richter;S. Lew;R. Seetharaman;C. Bryan;Z. Lech;G. Kiss;R. Moretti;M. Maglaqui;R. Xiao;E. Kohan;M. Smith;J.K. Everett;R. Nguyen;V. Pande;D. Hilvert;G. Kornhaber;D. Baker;G.T. Montelione;J.F. Hunt;L. Tong | To be published | |||| | null | Directed evolution and rational design of a de novo designed esterase toward improved catalysis. northeast structural genomics consortium (nesg) target or184 | unknown function;northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;structural genomics, unknown function;nesg | 3u1o(874) | 2uvh(813);2uvi(813);2uvj(813);2uvg(809);3jzj(66);3k00(66);3k02(66);4g68(64);3uor(62);3k01(61);2z8f(60);2z8d(60);2z8e(60);3quf(57);8vqk(55);2i58(51);2hq0(51);2b3b(51);2b3f(51);2heu(51);2hfb(51);2gh9(50) | null | null | 3u1o(874) | 2uvh(813) | 3u1o(0.9394999743) | 2uvg(0.9423000216) | 3.40.190.180;3.40.50.10860;3.40.50.2300;3.40.190.10;3.40.190.80;3.40.50.11060 | null |
4k0c | 2013-04-24 | other | id:A,B;type:D;source:synthetic construct;length:169;seq_nat:MARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTVPGAWVGGLPAEAVRRVMVEEIKKAPDTLEVTGVHGTEKSAEACRRARLEHHHHHH;seq_unnat:(MSE)ARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAV... | 17,873.129 | P 21 21 21 | 30.026|76.032|128.355|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | A. Kuzin;S. Lew;S. Rajagopalan;J. Seetharaman;M. Maglaqui;R. Xiao;D. Lee;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt | To be published | |||| | null | Crystal structure of the computationally designed serine hydrolase. northeast structural genomics consortium (nesg) target or317 | unknown function;northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;structural genomics, unknown function;nesg | 4ess(314);4kyb(313);4etj(310);4j4z(309) | 4gvv(311);4jgk(310);4jll(309);4jca(309);4etk(305);4jvv(293);2dx6(265);2x47(83);1vhu(71);3q6z(71);3vfq(71);4d86(71);1spv(70);4iqy(69);2bfq(63);2bfr(63);1hjz(63);3q71(59);4abk(57);4abl(57) | null | null | 4ess(314) | 4gvv(311) | 3v45(0.940599978) | 4gvv(0.9426000118) | null | null |
4ky3 | 2013-06-19 | other | id:A,B,C;type:D;source:synthetic construct;length:174;seq_nat:MGDIQVQVNIDDNGKNFDYTYTVTTESELQKVLNELMDYIKKQGAKRVRISITARSSKEAYKFLAILAKVFAELGYNDINRKMTVRFRGDDLEALEKALKEMIRQARKFAGTVTYTLDGNDLEITITGVPRQVLEELAKEAERLAKEFNITITITVTVEGQLGSLEHHHHHH;seq_unnat:(MSE)GDIQVQVNIDDNGKNFDYTYTVTTESELQKVLNEL(MSE)DYIKKQGAKRVRISITARSSKEAYKFLAIL... | 19,842.973 | P 21 21 21 | 61.207|71.850|118.008|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | I.C. King;J. Gleixner;L. Doyle;A. Kuzin;J.F. Hunt;R. Xiao;G.T. Montelione;B.L. Stoddard;F. DiMaio;D. Baker | "Precise assembly of complex beta sheet topologies from de novo designed building blocks", Elife, 4 | 10.7554/eLife.11012|26650357||2050-084X| | US | Three-dimensional structure of the orthorhombic crystal of computationally designed insertion domain , northeast structural genomics consortium (nesg) target or327 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg | 4kyz(337);2mtl(147);2kl8(138);5cw9(123);4pww(122);2n4e(121);2n41(121);4nez(115);4ney(115);4rjv(113);9qud(106);9qui(106);9quc(106);6zv9(106);6wxp(106);6wxo(106);9qul(103);9quo(103);2mbl(74);2mbm(74);9qup(55) | 4hhu(125) | null | null | 4kyz(337) | 4hhu(125) | 4kyz(0.9223999977) | 4hhu(0.5842999816) | 3.30.420.40;3.30.70.1140;3.30.70.790;3.30.70.2860;3.30.70.2250;3.30.70.1430;3.30.160.330;6.20.250.30;3.30.160.60;3.30.70.80;3.30.70.2810;3.30.70.1280;3.30.70.870;3.30.70.1520;3.30.1490.170;3.30.70.860;3.30.70.250;3.30.70.240;3.30.70.600;3.30.70.2280;3.30.70.1440;3.30.70.1750;3.30.70.2940;3.30.70.1130;3.30.70.340;3.30.7... | null |
4kyb | 2013-06-19 | other | id:A,B;type:D;source:synthetic construct;length:169;seq_nat:MARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTVGGAWVGGLPAEAVCRVMREEIKKAPDTLEVTGVHGTEKSAEAPRRARLEHHHHHH;seq_unnat:MARIRDVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDE... | 17,737.26 | P 21 21 21 | 30.054|76.401|132.584|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | A. Kuzin;S. Lew;S. Rajagopalan;J. Seetharaman;L. Mao;R. Xiao;D. Lee;S. Raja;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt | To be published | |||| | null | Crystal structure of de novo designed serine hydrolase osh55.14_e3, northeast structural genomics consortium target or342 | protein structure initiative;northeast structural genomics consortium (nesg) target or342;structural genomics;psi-biology;de novo protein | 4k0c(314);4ess(312);4etj(309);4j4z(308) | 4gvv(310);4jll(308);4jca(308);4jgk(307);4etk(306);4jvv(292);2dx6(263);2x47(84);3q6z(72);3vfq(72);4d86(72);1spv(70);1vhu(70);4iqy(68);2bfq(62);2bfr(62);1hjz(62);4abk(57);4abl(57);3q71(57) | null | null | 4k0c(314) | 4gvv(310) | 4k0c(0.9301000237) | 4gvv(0.9277999997) | 3.40.50.10710;3.40.220.10;3.40.50.300;3.40.50.720;3.40.220.20;3.40.50.2300;3.40.50.1980 | null |
4kyv | 2013-07-24 | other | id:A,B;type:D;source:synthetic construct;length:309;seq_nat:MGHHHHHHSHMGSEIGTGFPFDPHYVEVLGERMHYVDVGPRDGTPVLFLHGNPTSSYLWRNIIPHVAPSHRCIAPDLIGMGKSDKPDLDYFFDDHVRYLDAFIEALGLEEVVLVIHDWGSALGFHWAKRNPERVKGIACMEFIRPIPTWDEWPEFARETFQAFRTADVGRELIIDQNAFIEGALPMGVVRPLTEVEMDHYREPFLKPVDREPLWRLPNELPIAGEPANIVALVEAYMNWLHQSPVPKLLFWGTPGVLIPP... | 34,951.566 | P 1 21 1 | 42.938|94.770|73.483|90.000|93.110|90.000 | X-RAY DIFFRACTION | null | A. Kuzin;S. Lew;J. Seetharaman;M. Maglaqui;R. Xiao;E. Kohan;H. Wang;J.K. Everett;T.B. Acton;G. Kornhaber;G.T. Montelione;J.F. Hunt;L. Tong | To be published | |||| | null | Crystal structure of dehalogenase halotag2 with halts at the resolution 1.8a. northeast structural genomics consortium (nesg) target or150 | northeast structural genomics consortium;protein structure initiative;halogenase;structural genomics;psi-biology;halts;de novo protein;nesg | 8oe2(572);8oe6(545);7ome(240) | 4kaa(662);4kac(662);1bn6(620);1bn7(620);3fbw(620);4e46(619);3fwh(619);3g9x(619);4f5z(617);1cqw(616);3rk4(616);4f60(614);4kaf(612);4kaj(612);4fwb(611);3sk0(597);2v9z(594);9caf(592);9cae(592);9hq4(591);9hkf(530);3a2l(290);3afi(286);3a2m(285);3a2n(285);3u1t(278);1mj5(258);1iz7(256);1k63(256);1iz8(256);1k5p(256);1k6e(256);... | 8oe2(0.9707000256);8oe6(0.959800005) | 3fbw(0.9779000282);4kaa(0.9684000015);1bn7(0.9718000293);3g9x(0.9704999924);3fwh(0.9684000015);4e46(0.9718000293);3rk4(0.9671999812);4f5z(0.9684000015);4kaf(0.9620000124) | 8oe2(572) | 4kaa(662) | 8oe2(0.9707000256) | 3fbw(0.9779000282) | 3.40.50.450;3.40.50.720;3.40.50.1820;3.40.50.1110;3.40.50.300;3.40.50.980;3.40.50.2300;3.40.50.261 | null |
4kyz | 2013-07-24 | other | id:A,B,C,D;type:D;source:synthetic construct;length:174;seq_nat:MGDIQVQVNIDDNGKNFDYTYTVTTESELQKVLNELMDYIKKQGAKRVRISITARSSKEAYKFLAILAKVFAELGYNDINRKMTVRFRGDDLEALEKALKEMIRQARKFAGTVTYTLDGNDLEITITGVPRQVLEELAKEAERLAKEFNITITITVTVEGQLGSLEHHHHHH;seq_unnat:(MSE)GDIQVQVNIDDNGKNFDYTYTVTTESELQKVLNEL(MSE)DYIKKQGAKRVRISITARSSKEAYKFLA... | 19,842.973 | P 1 | 43.819|55.402|78.258|82.030|80.340|90.030 | X-RAY DIFFRACTION | null | I.C. King;J. Gleixner;L. Doyle;A. Kuzin;J.F. Hunt;R. Xiao;G.T. Montelione;B.L. Stoddard;F. DiMaio;D. Baker | "Precise assembly of complex beta sheet topologies from de novo designed building blocks", Elife, 4 | 10.7554/eLife.11012|26650357||2050-084X| | US | Three-dimensional structure of triclinic form of de novo design insertion domain, northeast structural genomics consortium (nesg) target or327 | northeast structural genomics consortium;domain insertion;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg | 4ky3(337);2mtl(147);2kl8(138);5cw9(123);4pww(122);2n4e(121);2n41(121);4nez(115);4ney(115);4rjv(113);9qud(106);9qui(106);9quc(106);6zv9(106);6wxp(106);6wxo(106);9qul(103);9quo(103);2mbl(74);2mbm(74);9qup(55) | 4hhu(125) | null | null | 4ky3(337) | 4hhu(125) | 4ky3(0.9082999825) | 4hhu(0.5751000047) | 3.30.420.40;3.30.70.1140;3.30.70.790;3.30.70.2860;3.30.70.2250;3.30.70.80;3.30.70.2810;3.30.70.870;3.30.70.1280;3.30.1370.10;3.30.70.1520;3.30.70.250;3.30.70.860;3.30.70.2350;3.30.70.240;3.30.70.600;3.30.70.1750;3.30.70.1130;3.30.70.330;3.30.70.2750;3.30.70.1940;3.30.70.1170;3.30.70.2430;3.30.70.1320;3.30.160.110;3.30.... | null |
4l8i | 2014-02-12 | other | id:A,B;type:D;source:synthetic construct;length:116;seq_nat:GSMSDIRKDLEERFDKLVEALKNKVDKMKAAFRMDQFHEERMKDWFKDLRKEVEQMRRAVRNYASEALSKINDLPITNDDKKLASNDVLKLVAEVWKKLEAILADVEAWFTHHHH;seq_unnat:GSMSDIRKDLEERFDKLVEALKNKVDKMKAAFRMDQFHEERMKDWFKDLRKEVEQMRRAVRNYASEALSKINDLPITNDDKKLASNDVLKLVAEVWKKLEAILADVEAWFTHHHH | 13,709.756 | P 31 2 1 | 53.406|53.406|178.508|90.000|90.000|120.000 | X-RAY DIFFRACTION | null | B.E. Correia;J.T. Bates;R.J. Loomis;G. Baneyx;C. Carrico;J.G. Jardine;P. Rupert;C. Correnti;O. Kalyuzhniy;V. Vittal;M.J. Connell;E. Stevens;A. Schroeter;M. Chen;S. Macpherson;A.M. Serra;Y. Adachi;M.A. Holmes;Y. Li;R.E. Klevit;B.S. Graham;R.T. Wyatt;D. Baker;R.K. Strong;J.E. Crowe;P.R. Johnson;W.R. Schief | "Proof of principle for epitope-focused vaccine design", Nature, 507, 201-206 | 10.1038/nature12966|24499818|0006|0028-0836|NATUAS | UK | Crystal structure of rsv epitope scaffold ffl_005 | immune system;three-helix bundle | 4n9g(127);3lhp(92);6ywd(53) | 1y69(66);3lf9(53) | null | null | 4n9g(127) | 1y69(66) | 3lhp(0.7675999999) | 1is1(0.7390999794) | 1.20.58.60;1.20.120.220;1.20.58.400;1.10.132.30;1.20.58.120;1.10.287.2500;1.20.58.1440;1.20.58.70;1.20.81.20;1.20.58.420;1.20.58.80;1.20.58.1520;1.10.287.1060;1.20.58.220;1.10.132.20;1.10.287.990;1.20.58.340;1.20.58.1000;1.20.58.240;1.20.58.310;1.20.58.90;1.20.58.830 | null |
4lny | 2013-08-07 | other | id:A;type:D;source:artificial gene;length:262;seq_nat:MPRYLKGWLEDVVQLSLRRPSVRASRQRPIISLNERILEFNKRNITAIIAEYKRKDPSGLDVERDPIEYAKFMERYAVGLFISTEEKYFNGSYETLRKIASSVSIPILMYDFIVKESQIDDAYNLGADTVALIVKILTERELESLLEYARSYGMEPLIIINDENDLDIALRIGARFIGIAARDWETGEINKENQRKLISMIPSNVVKVAKEGISERNEIEELRKLGVNAFVTASGSLMRNPEKIKELIEGSLEHHHHHH;seq_un... | 30,123.574 | P 21 21 21 | 41.125|63.161|86.436|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;M. Su;S. Bjelic;Y. Kipnis;L. Wang;S. Sahdev;R. Xiao;M. Maglaqui;S. Kogan;D. Baker;J.K. Everett;T.B. Acton;G.T. Montelione;J.F. Hunt;L. Tong | To be published | |||| | null | Crystal structure of engineered protein, northeast structural genomics consortium target or422 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg;engineered protein | 4a29(473);9mya(471);9myb(450);4ijb(447);4lt9(428) | 3tc7(500);8w3y(470);8w3z(470);8w40(470);4a2s(467);3tc6(467);3ud6(462);3nxf(462);3o6y(462);4a2r(459);3nyz(455);3nz1(455);3hoj(437);1juk(437);1jul(437);1igs(437);1lbl(434);1a53(434);1lbf(434);3uxa(428);3uxd(428);3uy7(428);3uy8(421);3uyc(410);3uzj(406);3uz5(406);2c3z(389);1i4n(102);3qja(102);3t40(102);3t44(102);3t78(102);... | null | null | 4a29(473) | 3tc7(500) | 9mya(0.9430999756) | 1juk(0.942900002) | 3.40.50.12600 | null |
4loa | 2013-08-07 | other | id:A,B;type:U;source:unknown;length:175;seq_nat:MSLAKNIVFIGESGSGKSTLARALAKDLDLVFLDSDFLIEQKFNQKASEIWEQYGWNFALEQEQKMADFFSSCEKACIATSGSFVNVSNLEKAGFCIYLKADFEYLKKRLDKDEISKFPLFSDEIKWKKHYNETLSKYEQKANFILNIENKNIDELLSEIKKVIKLEHHHHHH;seq_unnat:(MSE)SLAKNIVFIGESGSGKSTLARALAKDLDLVFLDSDFLIEQKFNQKASEIWEQYGWNFALEQEQK(MSE)ADFFSSCEKACIAT... | 20,255.766 | P 1 | 34.485|44.335|57.515|71.070|75.970|86.860 | X-RAY DIFFRACTION | null | A. Kuzin;S. Lew;S.M. Vorobiev;J. Seetharaman;S. Sahdev;R. Xiao;M. Maglaqui;S. Kogan;O. Khersonsky;J.K. Everett;T.B. Acton;G.T. Montelione;J.F. Hunt;L. Tong | To be published | |||| | null | X-ray structure of the de-novo design amidase at the resolution 1.8a, northeast structural genomics consortium (nesg) target or398 | amidase;protein structure initiative;northeast structural genomics consortium (nesg);structural genomics;psi-biology;de novo protein;de novo design | null | 1via(286);3n2e(78);3mrs(78);1zuh(76);1zui(76);3hr7(76);3muf(76);3vaa(53);1kag(51);3trf(51) | null | null | 4loa(0) | 1via(286) | 5gaj(0.4347000122) | 1via(0.9190999866) | 3.40.50.360;3.40.50.450;3.40.50.300;3.40.50.2000;3.40.50.2300;3.40.35.10;3.40.50.1980;3.40.50.11230 | null |
4lpt | 2014-01-29 | other | id:A,B,C,D,E,F;type:D;source:artificial gene;length:104;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLGSYVFEHDVMLPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLGSYVFEHDVMLPLSAEFTTGGHHHHHH | 11,383.629 | P 21 21 21 | 50.520|64.130|194.550|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of monomeric tencon variant p54cr4-31 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpv(186);4lpw(186);4lpx(184);4lpy(181);4lpu(170);4m6a(169);5l2h(166);4u3h(65);9f00(54);9y5y(53) | 3tes(182);3teu(81);3t1w(61);4gh7(59);2ck2(57);2rb8(57);1ttf(56);1ttg(56);3qwq(56);1mfn(56);2mfn(56);1fnf(56);3qwr(55);2cui(55);2ocf(54);1fna(53);4je4(53);1qr4(53);2rbl(52);3uyo(51);2cum(51) | null | null | 4lpv(186) | 3tes(182) | 5l2h(0.8396999836) | 3tes(0.8981000185) | 2.60.40.2920;2.60.40.1940;2.60.40.1230;2.60.40.650;2.60.40.3340;2.60.40.2140;2.60.40.380;2.60.40.3760;2.60.40.2400;2.60.40.2710;2.60.40.10;2.60.40.350;2.60.40.3880;2.60.40.60;2.60.40.3580;2.60.40.1250;2.60.40.290;2.60.40.2420;2.60.40.1200;2.60.40.1870;2.60.40.1220;2.60.40.3780;2.60.40.1930 | null |
4lpu | 2014-01-29 | other | id:A,B;type:D;source:artificial gene;length:99;seq_nat:MLPAPKNLVVSEVTEDSLRLSWDSPPNWYDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVYYVALSNPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWDSPPNWYDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVYYVALSNPLSAEFTTGGHHHHHH | 10,988.093 | P 61 2 2 | 84.730|84.730|127.440|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of tencon variant p40ar2-32r2 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpw(179);4lpx(177);4lpy(177);4lpv(173);4lpt(169);5l2h(166);4m6a(161);4u3h(68);9y5y(55);9f00(53) | 3tes(174);3teu(79);4gh7(64);2rb8(61);3qwq(59);4je4(57);2rbl(57);3csb(57);1ttf(56);1ttg(56);2ck2(56);2ocf(56);1fnf(56);2cum(55);3ch8(55);3t1w(55);3uyo(54);1fna(53);3qwr(53);2gee(53);1j8k(52);2cui(52);3rzw(50);4huk(50);4hul(50);4hum(50);4hun(50) | null | null | 4lpw(179) | 3tes(174) | 4lpv(0.8957999945) | 3tes(0.9138000011) | 2.60.40.2920;2.60.40.1940;2.60.40.3920;2.60.40.2140;2.60.40.380;2.60.40.3760;2.60.40.2400;2.60.40.2710;2.60.40.10;2.60.40.350;2.60.40.3080;2.60.40.3580;2.60.40.2060;2.60.40.290;2.60.40.2420;2.60.40.1200;2.60.40.1870;2.60.40.1840;2.60.40.1220;2.60.40.1930 | null |
4lpv | 2014-01-29 | other | id:A,B;type:D;source:artificial gene;length:100;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFMIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLVVHKLTFPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFMIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLVVHKLTFPLSAEFTTGGHHHHHH | 10,949.251 | H 3 | 106.460|106.460|115.330|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of tencon variant p41br3-42 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpx(187);4lpt(186);4lpw(184);4lpy(184);4lpu(174);4m6a(169);5l2h(164);4u3h(64);9y5y(55);9f00(53) | 3tes(184);3teu(83);4gh7(60);3t1w(60);2ck2(56);1ttf(55);1ttg(55);2rb8(55);2cui(55);3qwq(55);1mfn(55);2mfn(55);1fnf(55);2ocf(53);1qr4(53);1fna(52);4je4(52);3qwr(52);3ch8(52);3uyo(51);2rbl(50);3csb(50) | null | null | 4lpx(187) | 3tes(184) | 4lpy(0.9167000055) | 3tes(0.8894000053) | 2.60.40.380;2.60.40.2420;2.60.40.1200;2.60.40.3760;2.60.40.1940;2.60.40.2920;2.60.40.3920;2.60.40.2140;2.60.40.1220;2.60.40.2710;2.60.40.290;2.60.40.10;2.60.40.350;2.60.40.3080;2.60.40.1930;2.60.40.3580 | null |
4lpw | 2014-01-29 | other | id:A,B;type:D;source:artificial gene;length:101;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVFPYQYTMSNPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVFPYQYTMSNPLSAEFTTGGHHHHHH | 11,123.275 | P 21 3 | 99.330|99.330|99.330|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of tencon variant a6 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpx(190);4lpy(190);4lpt(186);4lpv(183);4lpu(180);4m6a(170);5l2h(161);4u3h(64);9f00(57);9y5y(53) | 3tes(183);3teu(84);2rb8(61);4gh7(61);3qwq(58);4je4(57);3t1w(57);2ck2(56);2rbl(55);3qwr(55);2ocf(55);1mfn(55);2mfn(55);3ch8(55);1ttf(54);1ttg(54);1fnf(54);3uyo(53);2cui(53);1qr4(52);1fna(51);3csb(51);3b83(50);3t04(50);2cum(50);2obg(50) | 4lpx(0.9532999992) | null | 4lpx(190) | 3tes(183) | 4lpx(0.9532999992) | 3tes(0.9237999916) | 2.60.40.380;2.60.40.2420;2.60.40.1200;2.60.40.2410;2.60.40.3760;2.60.40.2400;2.60.40.3920;2.60.40.2140;2.60.40.1220;2.60.40.2710;2.60.40.290;2.60.40.10;2.60.40.3970;2.60.40.3780;2.60.40.3080;2.60.40.1930;2.60.40.3580 | null |
4lpx | 2014-01-29 | other | id:A;type:D;source:artificial gene;length:101;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLIPFPNLSNPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVLIPFPNLSNPLSAEFTTGGHHHHHH | 10,987.189 | P 41 3 2 | 100.630|100.630|100.630|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of tencon variant d4 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpw(190);4lpy(188);4lpv(186);4lpt(184);4lpu(178);4m6a(171);5l2h(160);4u3h(64);9y5y(54);9f00(53) | 3tes(184);3teu(82);2rb8(60);2ck2(57);3qwq(57);4gh7(57);1ttf(56);1ttg(56);4je4(56);1fnf(56);3t1w(56);1mfn(55);2mfn(55);2rbl(54);1fna(53);2cui(53);2ocf(53);3csb(53);1qr4(52);3uyo(51);3t04(50) | null | null | 4lpw(190) | 3tes(184) | 4lpw(0.932099998) | 3tes(0.9002000093) | 2.60.40.1940;2.60.40.1230;2.60.40.3920;2.60.40.2140;2.60.40.380;2.60.40.3760;2.60.40.2710;2.60.40.10;2.60.40.350;2.60.40.3880;2.60.40.60;2.60.40.3580;2.60.40.1250;2.60.40.2030;2.60.40.290;2.60.40.2420;2.60.40.1200;2.60.40.1220;2.60.40.3780;2.60.40.1930 | null |
4lpy | 2014-01-29 | other | id:A,B;type:D;source:artificial gene;length:102;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVFMKMSLSKSNPLSAEFTTGGHHHHHH;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVFMKMSLSKSNPLSAEFTTGGHHHHHH | 11,147.449 | P 32 2 1 | 80.340|80.340|73.520|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;T.J. Malia;J. Luo;S.A. Jacobs;W. Chan;D. Domingo;A. Baker;K.T. O'Neil;G.L. Gilliland | "C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold", Proteins, 82, 1359-1369 | 10.1002/prot.24502|24375666|0867|0887-3585|PSFGEY | US | Crystal structure of tencon variant g10 | fibronectin type iii fold;de novo protein;alternate scaffold | 4lpw(190);4lpx(188);4lpv(183);4lpt(181);4lpu(178);4m6a(172);5l2h(162);4u3h(64);9y5y(60);9f00(55) | 3tes(184);3teu(83);2rb8(63);4gh7(60);2ocf(59);3t1w(59);2ck2(58);2rbl(58);1ttf(57);1ttg(57);1fnf(57);4je4(55);1mfn(55);2mfn(55);1fna(54);3qwq(54);3uyo(53);2cui(53);1qr4(52);1ten(51);2cum(50);3qwr(50) | null | null | 4lpw(190) | 3tes(184) | 4lpv(0.9358000159) | 3tes(0.9275000095) | 2.60.40.1940;2.60.40.3920;2.60.40.2140;2.60.40.380;2.60.40.3760;2.60.40.2400;2.60.40.2710;2.60.40.10;2.60.40.3970;2.60.40.350;2.60.40.60;2.60.40.3080;2.60.40.3580;2.60.40.290;2.60.40.2420;2.60.40.1200;2.60.40.1220;2.60.40.3780;2.60.40.1930 | null |
4lt9 | 2013-08-14 | other | id:A;type:D;source:artificial gene;length:272;seq_nat:MPRYLKGWLEDVVQLSLRRPSVHASRQRPIISLNERILEFNKSNITAIIAYYTRKSPSGLDVERDPIEYAKFMERYAVGLSIKTEEKYFNGSYEMLRKIASSVSIPILMNDFIVKESQIDDAYNLGADTVLLIASILTERELESLLEYARSYGMEPLILINDENDLDIALRIGARFISIFSVDKSKLSSTGGYSSSYSINKENQRKLISMIPSNVVKVAATFKVSERNEIEELRKLGVNAFLISSSLMRNPEKIKELIEGSLEHHH... | 31,082.52 | P 21 21 21 | 39.287|73.333|80.738|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;M. Su;S. Bjelic;Y. Kipnis;L. Wang;S. Sahdev;R. Xiao;S. Kogan;M. Maglaqui;D. Baker;J.K. Everett;T.B. Acton;G.T. Montelione;J.F. Hunt;L. Tong | To be published | |||| | null | Crystal structure of engineered protein, northeast structural genomics consortium target or404 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg;engineered protein | 4a29(448);9mya(446);9myb(438);4ijb(432);4lny(429) | 4a2r(470);4a2s(456);8w3y(441);8w3z(441);8w40(441);3tc7(436);3tc6(435);3ud6(433);3nxf(433);3o6y(433);3nyz(421);3nz1(421);3hoj(414);1juk(411);1jul(411);1igs(411);1lbl(409);1a53(409);1lbf(409);3uy7(402);3uxa(401);3uxd(401);3uy8(397);3uyc(392);3uzj(383);3uz5(383);2c3z(366);1j5t(90);1i4n(90);1jcm(83);3qja(83);3t40(83);3t44(... | null | null | 4a29(448) | 4a2r(470) | 4ijb(0.8769000173) | 3uy7(0.8614000082) | 3.20.20.190;3.20.20.390;3.20.20.60;3.20.20.380;3.20.20.410;3.20.20.120;3.20.20.150;3.20.20.220;3.20.20.80;3.20.20.20;3.20.20.110;3.20.20.70;3.20.20.370;3.20.20.140 | null |
4m6a | 2014-02-26 | other | id:A,B,C,D,E,F,G,H,I,J;type:D;source:synthetic construct;length:93;seq_nat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVKGGHRSNPLSAEFTTGG;seq_unnat:MLPAPKNLVVSEVTEDSLRLSWTAPDAAFDSFLIQYQESEKVGEAINLTVPGSERSYDLTGLKPGTEYTVSIYGVKGGHRSNPLSAEFTTGG | 9,901.954 | P 1 21 1 | 87.370|41.880|128.180|90.00|92.82|90.00 | X-RAY DIFFRACTION | null | J. Luo;A. Teplyakov;G. Obmolova;T.J. Malia;W. Chan;S.A. Jacobs;K.T. O'Neil;G.L. Gilliland | "N-terminal beta-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions", Proteins, 82, 1527-1533 | 10.1002/prot.24517|24464739|0867|0887-3585|PSFGEY | US | N-terminal beta-strand swapping in a consensus derived alternative scaffold driven by stabilizing hydrophobic interactions | b-strand swapping;alternative scaffold;tencon;de novo protein;fn3-like domain | 4lpy(173);4lpx(172);4lpw(171);4lpv(170);4lpt(170);4lpu(163);5l2h(148);4u3h(70);9y5y(55);9f00(54) | 3tes(189);3teu(77);1qr4(63);2rb8(62);1mfn(62);2mfn(62);2cui(61);2ck2(59);1ten(57);1ttf(57);1ttg(57);1fnf(57);2rbl(56);1fna(55);2ocf(55);4gh7(55);3t1w(55);4je4(54);1fnh(54);3r8q(54);2cum(53);2gee(53);1j8k(52);3uyo(51);3qwq(51);2qbw(51);1tdq(51);3ch8(50);3csb(50) | null | null | 4lpy(173) | 3tes(189) | 5l2h(0.872699976) | 3tes(0.8891000152) | 2.60.40.1940;2.60.40.2140;2.60.40.2560;2.60.40.380;2.60.40.3750;2.60.40.3760;2.60.40.2400;2.60.40.2710;2.60.40.10;2.60.40.3970;2.60.40.60;2.60.40.2190;2.60.40.3010;2.60.40.2420;2.60.40.1200;2.60.40.1220;2.60.40.3780;2.60.40.1120;2.60.40.4070;2.60.40.1930;2.60.40.1590 | null |
4n6t | 2014-04-09 | other | id:A;type:D;source:ARTIFICIAL GENE;length:79;seq_nat:ENSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQVVAGTMYYLTLEAKDGGKKKLYEAKVWVKPWENFKELQEFKPV;seq_unnat:ENSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQVVAGTMYYLTLEAKDGGKKKLYEAKVWVKPWENFKELQEFKPV | 9,286.674 | P 41 | 35.855|35.855|61.847|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | C. Tiede;A.A. Tang;S.E. Deacon;U. Mandal;J.E. Nettleship;R.L. Owen;S.E. George;D.J. Harrison;R.J. Owens;D.C. Tomlinson;M.J. McPherson | "Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications", Protein Eng.Des.Sel., 27, 145-155 | 10.1093/protein/gzu007|24668773||1741-0126| | UK | Adhiron: a stable and versatile peptide display scaffold - full length adhiron | consensus protein;de novo protein;protein scaffold | 4n6u(158);7zqa(134);7zq8(134);5a0o(128) | 9guc(134);1eqk(120);3ima(119);2l4v(113);3ul6(112);3ul5(112);4lzi(108);2w9p(99);2w9q(99) | 4n6u(0.9819999933) | null | 4n6u(158) | 9guc(134) | 4n6u(0.9819999933) | 3ima(0.92900002) | 3.10.450.40;3.10.450.750;3.10.450.120;3.10.450.560;3.10.450.10;3.30.200.150;3.30.200.70;3.10.450.540;3.30.200.20 | null |
4n6u | 2014-04-09 | other | id:A;type:D;source:ARTIFICIAL GENE;length:79;seq_nat:ENSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQVVAGTMYYLTLEAKDGGKKKLYEAKVWVKPWENFKELQEFKPV;seq_unnat:ENSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQVVAGTMYYLTLEAKDGGKKKLYEAKVWVKPWENFKELQEFKPV | 9,286.674 | P 41 | 36.373|36.373|59.243|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | C. Tiede;A.A. Tang;S.E. Deacon;U. Mandal;J.E. Nettleship;R.L. Owen;S.E. George;D.J. Harrison;R.J. Owens;D.C. Tomlinson;M.J. McPherson | "Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications", Protein Eng.Des.Sel., 27, 145-155 | 10.1093/protein/gzu007|24668773||1741-0126| | UK | Adhiron: a stable and versatile peptide display scaffold - truncated adhiron | consensus protein;de novo protein;protein scaffold | 4n6t(158);7zqa(134);7zq8(134);5a0o(128) | 9guc(134);1eqk(120);3ima(119);2l4v(113);3ul6(112);3ul5(112);4lzi(108);2w9p(99);2w9q(99) | 4n6t(0.9768000245) | null | 4n6t(158) | 9guc(134) | 4n6t(0.9768000245) | 3ima(0.923600018) | 6.10.250.770;1.20.5.420;1.20.5.2620;4.10.910.10;6.10.250.500;6.10.250.200;6.10.250.880;6.10.250.740;1.20.5.3960;6.10.250.2060;6.10.250.1090;6.10.250.2370;6.10.250.1210;2.60.40.2760;6.20.70.10;1.10.168.10;6.10.250.160;2.20.25.110;6.10.250.490;6.10.250.2230;6.20.50.130;6.10.20.80;6.10.250.30;1.20.5.460;1.20.5.740;6.10.25... | null |
4n9g | 2014-02-12 | other | id:A,E,H,M;type:N;source:Macaca mulatta;length:232;seq_nat:QVQLQESGPGLVKPSETLSLTCVVSGGSFSSYYWTWIRQSPGKGLEWIGEMNGNSGYTNYNPSLQSRVTISKDASKNQFSLKLTSLTAADTAVYYCARDAIVMVFTDMRGRVDVWGPGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK;seq_unnat:QVQLQESGPGLVKPSETLSL... | 24,461.527 | P 1 | 64.213|89.266|104.304|89.99|102.73|89.91 | X-RAY DIFFRACTION | null | B.E. Correia;J.T. Bates;R.J. Loomis;G. Baneyx;C. Carrico;J.G. Jardine;P. Rupert;C. Correnti;O. Kalyuzhniy;V. Vittal;M.J. Connell;E. Stevens;A. Schroeter;M. Chen;S. Macpherson;A.M. Serra;Y. Adachi;M.A. Holmes;Y. Li;R.E. Klevit;B.S. Graham;R.T. Wyatt;D. Baker;R.K. Strong;J.E. Crowe;P.R. Johnson;W.R. Schief | "Proof of principle for epitope-focused vaccine design", Nature, 507, 201-206 | 10.1038/nature12966|24499818|0006|0028-0836|NATUAS | UK | Crystal structure of a computationally designed rsv-presenting epitope scaffold and its elicited antibody 17hd9 | antibody;hairpin;immune system;epitope scaffold | 4l8i(135);3lhp(82);6ywd(50) | 1y69(68);3lf9(58);8ydk(50);8ydl(50) | null | null | 4l8i(135) | 1y69(68) | 4jlr(0.94599998) | 1iqp(0.8554000258) | 1.10.12.10;6.10.250.2850;6.10.140.480;1.10.287.1100;6.10.130.40;1.10.287.3280;6.10.250.890;1.10.286.70;1.10.880.10;6.10.250.3140;1.10.287.540;1.20.5.710;6.10.250.2310;1.10.287.2460;1.20.5.170;1.10.287.1090;6.10.140.150;1.10.1200.160;6.10.140.1560;1.20.5.510;1.20.50.10;1.10.286.90;1.10.1200.260;6.10.170.10;6.10.250.1890 | null |
4ndj | 2014-11-05 | other | id:A;type:N;source:Aequorea victoria;length:302;seq_nat:MTEFSEEQKKALDLAFYFDRRLTEEWRRYLSQRLGLNEEQIERWFRRKEQQIMVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKLICTTGKLPVPWPTLVTTLGYGLQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYITADKQKNGIKANFKIRHNIEDGGVQLADHYQQNTPIGDGPVLLPDNHYLSYQSKLSKDP... | 34,542.867 | P 42 2 2 | 104.420|104.420|80.190|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | Y. Mou;P.S. Huang;L.M. Thomas;S.L. Mayo | "Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants", J.Mol.Biol., 427, 2697-2706 | 10.1016/j.jmb.2015.06.006|26101839|0070|0022-2836|JMOBAK | UK | Crystal structure of a computational designed engrailed homeodomain variant fused with yfp | de novo protein;fluorescent protein, de novo protein;fluorescent protein;helix-turn-helix | null | null | null | null | null | null | null | null | null | null |
4ndk | 2014-11-05 | other | id:A,B;type:N;source:Aequorea victoria;length:302;seq_nat:MTEWSEEQKKALDLAFYFDRRLTPEWRRYLSQRLGLNEEQIERWFRRKEQQIMVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKLICTTGKLPVPFPTLVTTLGYGLQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYITADKQKNGIKANFKIRHNIEDGGVQLADHYQQNTPIGDGPVLLPDNHYLSYQSKLSK... | 34,510.871 | C 2 2 21 | 75.890|192.650|107.610|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | Y. Mou;P.S. Huang;L.M. Thomas;S.L. Mayo | "Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants", J.Mol.Biol., 427, 2697-2706 | 10.1016/j.jmb.2015.06.006|26101839|0070|0022-2836|JMOBAK | UK | Crystal structure of a computational designed engrailed homeodomain variant fused with yfp | de novo protein;fluorescent protein, de novo protein;fluorescent protein;helix-turn-helix | null | null | null | null | null | null | null | null | null | null |
4ndl | 2014-11-05 | other | id:B,A,C;type:N;source:Drosophila melanogaster;length:72;seq_nat:MGSSHHHHHHSSGLVPRGSHMTEFSEEQKKALDLAFYFDRRLTPEWRRYLSQRLGLNEEQIERWFRRKEQQI;seq_unnat:MGSSHHHHHHSSGLVPRGSHMTEFSEEQKKALDLAFYFDRRLTPEWRRYLSQRLGLNEEQIERWFRRKEQQI | 8,848.906 | C 2 2 21 | 87.550|167.770|29.740|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | Y. Mou;P.S. Huang;F.C. Hsu;S.J. Huang;S.L. Mayo | "Computational design and experimental verification of a symmetric protein homodimer", Proc.Natl.Acad.Sci.USA, 112, 10714-10719 | 10.1073/pnas.1505072112|26269568|0040|0027-8424|PNASA6 | US | Computational design and experimental verification of a symmetric homodimer | de novo protein;helix-turn-helix | null | null | null | null | null | null | null | null | null | null |
4ney | 2014-01-15 | other | id:A,B;type:U;source:unknown;length:175;seq_nat:MGEMMIIFEGDDLEALEKALKEMIRQARKFAGTVEYWLSGNRLMIRITGVPEQVRKELAKEAERLKAEFNIQVEYQIRGSGSGSGSEMMIIFEGDDLEALEKALKEMIRQARKFAGTVEYWLSGNRLMIRITGVPEQVRKELAKEAERLKAEFNIQVEYQIRTGSLEHHHHHH;seq_unnat:(MSE)GE(MSE)(MSE)IIFEGDDLEALEKALKE(MSE)IRQARKFAGTVEYWLSGNRL(MSE)IRITGVPEQVRKELAKEAERLKAE... | 20,456.123 | P 21 21 21 | 43.282|79.289|97.759|90.00|90.00|90.00 | X-RAY DIFFRACTION | This is a designed protein | R. Guan;Y.-R. Lin;N. Koga;R. Koga;J. Castellanos;J. Seetharaman;M. Maglaqui;S. Sahdev;L. Mao;R. Xiao;J.K. Everett;D. Baker;G.T. Montelione | To be published | |||| | null | Crystal structure of an engineered protein with ferredoxin fold, northeast structural genomics consortium (nesg) target or277 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;ferredoxin fold;protein engineering;de novo protein;nesg | 4nez(331);2mtl(135);5cw9(128);2kl8(126);4ky3(120);4kyz(120);4pww(109);9qul(98);9quo(98);6zv9(97);6wxp(97);6wxo(97);9qud(96);9qui(96);9quc(96);4rjv(95);9qup(57) | 4hhu(289) | null | null | 4nez(331) | 4hhu(289) | 4nez(0.9196000099) | 4hhu(0.8992999792) | 3.30.70.140;3.30.70.790;3.30.70.2860;3.30.70.1650;3.30.70.1430;3.30.70.80;3.30.70.2810;3.30.70.1280;3.30.70.870;3.30.70.1520;3.30.70.250;3.30.70.860;3.30.70.930;3.30.70.240;3.30.70.600;3.30.70.2280;3.30.70.1440;3.30.70.1380;3.30.70.1750;3.30.70.340;3.30.70.1130;3.30.70.330;3.30.70.2750;3.30.70.1940;3.30.70.980;3.30.70.... | null |
4nez | 2014-01-15 | other | id:A;type:U;source:unknown;length:174;seq_nat:MGEMMIIFEGDDLEALEKALKEMIRQARKFAGTVEYWLSGNRLMIRITGVPEQVRKELAKEAERLKAEFNIQVEYQIRGSGSGSGEMMIIFEGDDLEALEKALKEMIRQARKFAGTVEYWLSGNRLMIRITGVPEQVRKELAKEAERLKAEFNIQVEYQIRTGSLEHHHHHH;seq_unnat:(MSE)GE(MSE)(MSE)IIFEGDDLEALEKALKE(MSE)IRQARKFAGTVEYWLSGNRL(MSE)IRITGVPEQVRKELAKEAERLKAEFNI... | 20,369.045 | C 2 2 21 | 51.834|71.073|109.850|90.00|90.00|90.00 | X-RAY DIFFRACTION | This is a designed protein | null | To be published | |||| | null | Crystal structure of an engineered protein with ferredoxin fold, northeast structural genomics consortium (nesg) target or276 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;ferredoxin fold;protein engineering;de novo protein;nesg | 4ney(331);2mtl(137);5cw9(129);2kl8(126);4ky3(120);4kyz(120);4pww(109);9qul(97);9quo(97);6zv9(96);6wxp(96);6wxo(96);4rjv(95);9qud(95);9qui(95);9quc(95);9qup(57) | 4hhu(290) | null | null | 4ney(331) | 4hhu(290) | 4ney(0.9449999928) | 4hhu(0.8988999724) | 3.30.70.790;3.30.70.2860;3.30.70.80;3.30.70.1280;3.30.70.870;3.30.70.930;3.30.70.250;3.30.70.860;3.30.70.240;3.30.70.2740;3.30.70.1750;3.30.70.1130;3.30.70.330;3.30.70.980;3.30.70.2380;3.30.70.100;3.30.70.400;3.30.70.120;3.30.70.3400;3.30.70.920;3.30.70.260;3.30.70.1070;3.30.70.2730;3.30.70.60;3.30.70.3100;3.30.70.1710... | null |
4ntp | 2014-04-02 | other | id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P;type:U;source:unknown;length:16;seq_nat:ALVFFAEDAAIIGLAV;seq_unnat:(ORN)LV(PHI)FAED(ORN)AII(SAR)L(ORN)V | 1,889.025 | H 3 | 68.180|68.180|170.430|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | R.K. Spencer;H. Li;J.S. Nowick | "X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)", J.Am.Chem.Soc., 136, 5595-5598 | 10.1021/ja5017409|24669800|0004|0002-7863|JACSAT | US | Crystal structure of macrocycles containing a 17-23 (lv(phi)faed) and a 30-36 (aii(sar)l(orn)v) | phe19 changed to p-iodo-phenylalanine;protein binding;de novo protein, protein binding;de novo protein;amyloid;beta-sheet;beta-hairpin | null | null | 4ntr(1);4nw9(1);4nw8(1);5v65(1);5v64(0.9552999735) | null | 4nw8(30) | null | 4ntr(1) | null | null | null |
4ntr | 2014-04-02 | other | id:A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P;type:U;source:unknown;length:16;seq_nat:ALVFFAEDAAIIGLAV;seq_unnat:(ORN)LVFFAED(ORN)AII(SAR)L(ORN)V | 1,763.128 | H 3 | 68.000|68.000|169.260|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | R.K. Spencer;H. Li;J.S. Nowick | "X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)", J.Am.Chem.Soc., 136, 5595-5598 | 10.1021/ja5017409|24669800|0004|0002-7863|JACSAT | US | Crystal structure of macrocycles containing abeta 17-23 (lvffaed) and abeta 30-36 (aii(sar)l(orn)v) | amyloid beta-sheet mimic;de novo protein-protein binding complex;protein binding;de novo protein, protein binding;de novo protein;amyloid;beta-sheet;beta-hairpin | null | null | 4ntp(1);4nw9(1);4nw8(1);5v65(1);5v64(0.9546999931) | null | 4ntp(30) | null | 4ntp(1) | null | null | null |
4nw8 | 2014-04-02 | other | id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:16;seq_nat:ALVFFAEDAAIIGLAV;seq_unnat:(ORN)LV(PHI)(MEA)AED(ORN)AIIGL(ORN)V | 1,889.026 | P 32 2 1 | 68.680|68.680|93.840|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | R.K. Spencer;H. Li;J.S. Nowick | "X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)", J.Am.Chem.Soc., 136, 5595-5598 | 10.1021/ja5017409|24669800|0004|0002-7863|JACSAT | US | Crystal structure of macrocycles containing abeta17-23 (lv(phi)(mea)aed) and abeta30-36 (aiigl(orn)v) | protein binding;de novo protein, protein binding;de novo protein;amyloid;beta-sheet;beta-hairpin | null | null | 4nw9(1);4ntp(1);4ntr(1);5v65(1) | null | 4ntp(30) | null | 4nw9(1) | null | null | null |
4nw9 | 2014-04-02 | other | id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:16;seq_nat:ALVFFAEDAAIIGLAV;seq_unnat:(ORN)LVF(MEA)AED(ORN)AIIGL(ORN)V | 1,763.129 | P 32 2 1 | 68.220|68.220|92.990|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | R.K. Spencer;H. Li;J.S. Nowick | "X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36)", J.Am.Chem.Soc., 136, 5595-5598 | 10.1021/ja5017409|24669800|0004|0002-7863|JACSAT | US | Crystal structure of macrocycles containing abeta17-23 (lvf(mea)aed) and abeta30-36 (aiigl(orn)v) | protein binding;de novo protein, protein binding;de novo protein;amyloid;beta-sheet;beta-hairpin | null | null | 4nw8(1);4ntr(1);4ntp(1);5v65(1) | null | 4ntp(30) | null | 4nw8(1) | null | null | null |
4nwn | 2014-05-28 | other | id:A,C,E,G,I,K,M,O,Q,S,U,W;type:N;source:Campylobacter jejuni;length:194;seq_nat:MSQAIGILELTSIAKGMELGDAMLKSANVDLLVSKTISPGKFLLMLGGDIGAIQQAIETGTSQAGEMLVDSLVLANIHPSVLPAISGLNSVDKRQAVGIVETWSVAACISAADLAVKGSNVTLVRVHMAFGIGGKCYMVVAGDVLDVAAAVATASLAAGAKGLLVYASIIPRPHEAMWRQMVEGLEHHHHHH;seq_unnat:MSQAIGILELTSIAKGMELGDAMLKSANVDLLVSKT... | 19,928.221 | P 31 2 1 | 246.010|246.010|290.940|90.000|90.000|120.000 | X-RAY DIFFRACTION | null | N.P. King;J.B. Bale;W. Sheffler;D.E. McNamara;S. Gonen;T. Gonen;T.O. Yeates;D. Baker | "Accurate design of co-assembling multi-component protein nanomaterials", Nature, 510, 103-108 | 10.1038/nature13404|24870237|0006|0028-0836|NATUAS | UK | Computationally designed two-component self-assembling tetrahedral cage t32-28 | tetrahedron;nanomaterial;protein binding;nanostructure;multimerization;two-component;computational design;self-assembling;protein engineering;designed protein cage | null | null | null | null | null | null | null | null | null | null |
4nwo | 2014-05-28 | other | id:A;type:N;source:Shewanella oneidensis;length:179;seq_nat:MSKAKIGIVTVSDRASAGITADISGKAIILALNLYLTSEWEPIYQVIPDEQDVIETTLIKMADEQDCCLIVTTGGTGPAKRDVTPEATEAVCDRMMPGFGELMRAESLKEVPTAILSRQTAGLRGDSLIVNLPGDPASISDCLLAVFPAIPYCIDLMEGPYLECNEAMIKPFRPKAK;seq_unnat:MSKAKIGIVTVSDRASAGITADISGKAIILALNLYLTSEWEPIYQVIPDEQDVIETTLIKMADEQDCCLIVT... | 19,049.074 | F 4 3 2 | 213.520|213.520|213.520|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | N.P. King;J.B. Bale;W. Sheffler;D.E. McNamara;S. Gonen;T. Gonen;T.O. Yeates;D. Baker | "Accurate design of co-assembling multi-component protein nanomaterials", Nature, 510, 103-108 | 10.1038/nature13404|24870237|0006|0028-0836|NATUAS | UK | Computationally designed two-component self-assembling tetrahedral cage t33-15 | molybdenum cofactor biosynthesis protein;tetrahedron;isomerase;nanomaterial;protein binding;nanostructure;multimerization;two-component;computational design;mog;self-assembling;protein engineering;designed protein cage;chorismate mutase | null | null | null | null | null | null | null | null | null | null |
4nwp | 2014-05-28 | other | id:A,B,C,D;type:N;source:Pyrococcus horikoshii;length:174;seq_nat:MRITTKVGDKGSTRLFGGEEVWKDSPIIEANGTLDELTSFIGEAKHYVDEEMKGILEEIQNDIYKIMGEIGSKGKIEGISEERIAWLLKLILRYMEMVNLKSFVLPGGTLESAKLDVCRTIARRALRKVLTVTREFGIGAEAAAYLLALSDLLFLLARVIEIEKNKLKEVRS;seq_unnat:MRITTKVGDKGSTRLFGGEEVWKDSPIIEANGTLDELTSFIGEAKHYVDEEMKGILEEIQNDIYKIMGEIG... | 19,316.582 | H 3 2 | 113.350|113.350|634.880|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | N.P. King;J.B. Bale;W. Sheffler;D.E. McNamara;S. Gonen;T. Gonen;T.O. Yeates;D. Baker | "Accurate design of co-assembling multi-component protein nanomaterials", Nature, 510, 103-108 | 10.1038/nature13404|24870237|0006|0028-0836|NATUAS | UK | Computationally designed two-component self-assembling tetrahedral cage, t33-21, crystallized in space group r32 | tetrahedron;nanomaterial;protein binding;computational biology;nanostructure;multimerization;two-component;computational design;self-assembling;protein engineering;designed protein cage | null | null | null | null | null | null | null | null | null | null |
4nwq | 2014-05-28 | other | id:A;type:N;source:Pyrococcus horikoshii;length:174;seq_nat:MRITTKVGDKGSTRLFGGEEVWKDSPIIEANGTLDELTSFIGEAKHYVDEEMKGILEEIQNDIYKIMGEIGSKGKIEGISEERIAWLLKLILRYMEMVNLKSFVLPGGTLESAKLDVCRTIARRALRKVLTVTREFGIGAEAAAYLLALSDLLFLLARVIEIEKNKLKEVRS;seq_unnat:MRITTKVGDKGSTRLFGGEEVWKDSPIIEANGTLDELTSFIGEAKHYVDEEMKGILEEIQNDIYKIMGEIGSKGKIE... | 19,316.582 | F 41 3 2 | 272.180|272.180|272.180|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | N.P. King;J.B. Bale;W. Sheffler;D.E. McNamara;S. Gonen;T. Gonen;T.O. Yeates;D. Baker | "Accurate design of co-assembling multi-component protein nanomaterials", Nature, 510, 103-108 | 10.1038/nature13404|24870237|0006|0028-0836|NATUAS | UK | Computationally designed two-component self-assembling tetrahedral cage, t33-21, crystallized in space group f4132 | tetrahedron;isomerase;nanomaterial;protein binding;nanostructure;multimerization;two-component;computational design;transferase;self-assembling;protein engineering;designed protein cage | null | null | null | null | null | null | null | null | null | null |
4nwr | 2014-05-28 | other | id:A,C,E,G,I,K,M,O,Q,S,U,W,Y,a,c,e,g,i,k,m,o,q,s,u,w,y,0,2,4,6,8,AA,AC,AE,AG,AI,AK,AM,AO,AQ,AS,AU,AW,AY,BA,BC,BE,BG;type:N;source:uncultured bacterium;length:159;seq_nat:MESVNTSFLSPSLVTIRDFDNGQFAVLRIGRTGFPADKGDIDLCLDKMIGVRAAQIFLGDDTEDGFKGPHIRIRCVDIDDKHTYNAMVYVDLIVGTGASEVERETAEEEAKLALRVALQVDIADEHSCVTQFEMKLREELLSSDSFHPDK... | 17,788.957 | P 1 21 1 | 124.910|189.250|376.830|90.00|90.02|90.00 | X-RAY DIFFRACTION | null | N.P. King;J.B. Bale;W. Sheffler;D.E. McNamara;S. Gonen;T. Gonen;T.O. Yeates;D. Baker | "Accurate design of co-assembling multi-component protein nanomaterials", Nature, 510, 103-108 | 10.1038/nature13404|24870237|0006|0028-0836|NATUAS | UK | Computationally designed two-component self-assembling tetrahedral cage t33-28 | tetrahedron;nanomaterial;macrophage migration-inhibitory factors;protein binding;computational biology;nanostructure;integrons;multimerization;two-component;computational design;self-assembling;protein engineering;designed protein cage | null | null | null | null | null | null | null | null | null | null |
4o60 | 2015-03-25 | other | id:A,B;type:U;source:unknown;length:236;seq_nat:MSMDIGKKLLEAARAGHDDSVEVLLKKGADINAKDNVGVTPLHLAAVNGHLELVKLLLEKGADINATDLFGLTPLHFAATNGHLELVKLLLEKGADINAVDDVGVTPLHFAARNGHLELVKLLLEKGADINAMDMVGPTPLHFAAKNGHLELVKLLLEKDADINAEDHFGSTPLHSAAENGHLELVKLLLEKGADINARDKFGKTPFDLAIDNGNEDIAEVLQKAARSHHHHHH;seq_unnat:MSMDIGKKLLEAARAGHDDSVEVLLKK... | 25,223.826 | C 1 2 1 | 119.463|46.801|74.249|90.00|97.87|90.00 | X-RAY DIFFRACTION | Synthetic construct | E.B. Tikhonova;A.S. Ethayathulla;Y. Su;P. Hariharan;S. Xie;L. Guan | "A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen", Sci Rep, 5, 8070-8070 | 10.1038/srep08070|25627011||2045-2322| | UK | Structure of ankyrin repeat protein | ankyrin;de novo protein;designed ankyrin repeats | 4qfv(421);5le9(287);5lea(286);5le3(265);5le6(263);5le4(263);5le7(263);5le8(261);5leb(258);5lee(254);5led(254);5lec(254);5le2(254);7ujj(244);7qnl(237);7tbq(237);7tbn(234);7tcd(234);6fpa(209);6fpb(209);6fp9(208);7b4t(207);7zyu(205);7b4w(203);2xee(202);7z71(202);9gtk(202);9g8i(201);7z7e(201);8a1a(201);4hqd(199);8u1b(199);... | 4k5a(208);4hrm(205);4k5b(201);4hll(201);4hrl(198);4k5c(197);3noc(196);2v5q(195);3nog(195);4ydy(194);1svx(193);4f6r(193);4hna(193);4dx6(192);4u96(192);2p2c(192);4dx7(192);4u8v(192);9fhc(192);4u8y(192);4lnu(192);2j8s(192);9fhg(192);4drx(192);9fhj(192);9hao(192);4c48(192);9hci(192);4dx5(192);4u95(192);3zu7(191);9kcq(190);... | null | null | 4qfv(421) | 4k5a(208) | 4qfv(0.8651000261) | 1n11(0.8565999866) | 1.25.40.290;1.25.40.750;1.10.10.10;1.10.10.2400;1.25.40.70;1.10.220.10;1.25.60.10;1.25.40.580;1.25.10.10;1.25.40.420;1.25.40.180;1.25.40.10;1.25.40.90;1.25.40.320;1.25.40.850;1.25.40.350;1.25.40.20 | null |
4ow4 | 2014-12-17 | other | id:A,B;type:D;source:synthetic construct;length:124;seq_nat:HEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSA;seq_unnat:HEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLRILPDGTVDGTRDRSDQHIQLQLSA | 13,776.041 | P 21 21 21 | 52.861|68.634|76.044|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | L.M. Longo;O.S. Kumru;C.R. Middaugh;M. Blaber | "Evolution and design of protein structure by folding nucleus symmetric expansion", Structure, 22, 1377-1384 | 10.1016/j.str.2014.08.008|25242458|2005|0969-2126|STRUE6 | UK | Beta-trefoil designed by folding nucleus symmetric expansion ("phifoil") | de novo protein;beta-trefoil;protein design;de novo;top-down symmetric deconstruction;folding nucleus symmetric expansion | 3o4a(210);3o49(206);3o4d(205);3o4b(203);3o4c(201);4qkr(190);4d8h(184);4qks(182);3ogf(141);3ol0(72) | 4f34(194);3snv(190);3o3q(116);1nzk(109);1k5v(108);1m16(108);2hwm(107);2hz9(107);3fji(107);1jt5(107);1jt7(106);3fj8(106);2hw9(106);2hwa(106);2ntd(106);1jy0(106);1p63(105);3fj9(105);3fgm(105);1jt3(105);1jt4(105);1dzd(104);2axm(104);1axm(104);1djs(104);1hkn(104);2erm(104);1e0o(104);2afg(104);3ud7(104);3ud8(104);3ud9(104);... | null | null | 3o4a(210) | 4f34(194) | 3o49(0.9354000092) | 4f34(0.9333999753) | 2.80.10.50 | null |
4oxw | 2015-01-21 | other | id:A;type:D;source:Synthetic construct;length:120;seq_nat:SNAPDSLMKVSIPDFEKEGEGKSKHVMYKIKVKTGGEEWAVYRRYSDFYWLHKKLQQRYPELVPELPPKKWIYSALDEQILEKRKQGLEKYIQRIVSHPVLANDELVVSFLQAKAEHTG;seq_unnat:SNAPDSLMKVSIPDFEKEGEGKSKHVMYKIKVKTGGEEWAVYRRYSDFYWLHKKLQQRYPELVPELPPKKWIYSALDEQILEKRKQGLEKYIQRIVSHPVLANDELVVSFLQAKAEHTG | 13,984.079 | P 21 21 21 | 36.672|49.258|68.009|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | Y. Zhang;D.D. Shultis;G. Dodge | To be published | |||| | null | X-ray structure of a designed cisk-px domain | computational protein design;de novo protein;cisk-px;evodesign | null | 1xtn(79);1xte(79);2yps(78);2v14(74);2csk(69);2i4k(68);3iq2(66);4az9(61);4ikb(61);4ikd(61);1h6h(58);2dyb(58);4bgj(56);4pqo(55);4pqp(55);2ett(55);4akv(55);4pzg(53);4on3(53);3p0c(51);1ocs(51);1ocu(51);3fog(50);4has(50) | null | null | 4oxw(0) | 1xtn(79) | 6w90(0.4623000026) | 1xtn(0.8546000123) | 6.20.90.20;2.20.25.400;1.20.120.460;1.10.8.10;2.40.50.40;1.10.8.1170;1.20.1440.50;1.20.1270.350;2.20.25.510;1.20.58.90;2.20.25.10;1.10.287.10 | null |
4oyd | 2014-07-09 | other | id:A,C;type:N;source:Epstein-Barr virus;length:159;seq_nat:SAYSTREILLALCIRDSRVHGNGTLHPVLELAARETPLRLSPEDTVVLRYHVLLEEIIERNSETFTETWNRFITHTEHVDLDFNSVFLEIFHRGDPSLGRALAWMAWCMHACRTLCCNQSTPYYVVDLSVRGMLEASEGLDGWIHQQGGWSTLIEDNI;seq_unnat:SAYSTREILLALCIRDSRVHGNGTLHPVLELAARETPLRLSPEDTVVLRYHVLLEEIIERNSETFTETWNRFITHTEHVDLDFNSVFLEIFH... | 18,118.461 | P 1 21 1 | 52.103|113.869|55.670|90.00|90.03|90.00 | X-RAY DIFFRACTION | null | E. Procko;G.Y. Berguig;B.W. Shen;Y. Song;S. Frayo;A.J. Convertine;D. Margineantu;G. Booth;B.E. Correia;Y. Cheng;W.R. Schief;D.M. Hockenbery;O.W. Press;B.L. Stoddard;P.S. Stayton;D. Baker | "A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells", Cell, 157, 1644-1656 | 10.1016/j.cell.2014.04.034|24949974||1097-4172| | null | Crystal structure of a computationally designed inhibitor of an epstein-barr viral bcl-2 protein | viral protein-inhibitor complex;inhibitor;apoptosis;complex;viral protein/inhibitor | 8eja(150);9clb(150);7xge(117) | null | null | null | 8eja(150) | null | 9clb(0.9174000025) | 3lf9(0.8195000291) | 1.20.58.60;1.20.58.400;1.10.132.30;1.20.58.120;1.10.287.2500;1.20.58.1440;1.20.58.70;1.20.58.420;1.20.58.80;1.20.58.1520;1.10.287.1060;1.20.58.220;1.10.132.20;1.20.120.320;1.10.287.990;1.20.58.340;1.20.58.1000;1.20.58.240;1.20.120.660;1.20.58.310;1.20.58.90;1.20.58.830 | null |
4p4v | 2015-05-06 | other | id:A,B,C;type:U;source:unknown;length:16;seq_nat:AYLLFYTEAKVAAAVK;seq_unnat:(ORN)YLL(PHI)YTE(ORN)KVA(MAA)AVK | 1,986.14 | P 42 2 2 | 62.030|62.030|44.676|90.00|90.00|90.00 | X-RAY DIFFRACTION | This sequence occurs naturally in humans | R.K. Spencer;A.G. Kreutzer;P.J. Salveson;H. Li;J.S. Nowick | "X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin", J.Am.Chem.Soc., 137, 6304-6311 | 10.1021/jacs.5b01673|25915729||1520-5126|JACSAT | US | Hexamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kva(maa)avk | hexamer;beta-2 microglobulin;de novo protein;amyloid;iodophenylalanine | null | null | 4p4y(1) | 4wc8(0.9757000208) | 4p4w(30) | null | 4p4y(1) | 4wc8(0.9757000208) | null | null |
4p4w | 2015-05-06 | other | id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:16;seq_nat:AYLLFYTEAKVAVAVK;seq_unnat:(ORN)YLL(PHI)YTE(ORN)KVA(MVA)AVK | 2,014.193 | P 31 2 1 | 58.193|58.193|121.279|90.00|90.00|120.00 | X-RAY DIFFRACTION | This sequence occurs naturally in humans | R.K. Spencer;A.G. Kreutzer;P.J. Salveson;H. Li;J.S. Nowick | "X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin", J.Am.Chem.Soc., 137, 6304-6311 | 10.1021/jacs.5b01673|25915729||1520-5126|JACSAT | US | Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kva(mva)avk | macrocycle;dodecamer;beta-2-microglobulin;de novo protein;amyloid | null | null | 4p4x(1);4ntr(0.9656000137);4ntp(0.9671000242);4nw8(0.9631999731);4nw9(0.9613000154);5v64(0.9660999775);4p4z(0.9505000114);8gjc(0.9617000222);5v63(0.9639000297);7lib(0.9577000141) | 4wc8(1);4x0s(0.9746000171) | 4p4v(30) | null | 4p4x(1) | 4wc8(1) | null | null |
4p4x | 2015-05-06 | other | id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:16;seq_nat:AYLLFYTEAKVALAVK;seq_unnat:(ORN)YLL(PHI)YTE(ORN)KVA(MLE)AVK | 2,028.219 | P 41 2 2 | 61.343|61.343|113.963|90.00|90.00|90.00 | X-RAY DIFFRACTION | This sequence occurs naturally in humans | R.K. Spencer;A.G. Kreutzer;P.J. Salveson;H. Li;J.S. Nowick | "X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin", J.Am.Chem.Soc., 137, 6304-6311 | 10.1021/jacs.5b01673|25915729||1520-5126|JACSAT | US | Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kva(mle)avk | macrocycle;dodecamer;beta-2-microglobulin;de novo protein;amyloid | null | null | 4p4w(1);4ntr(0.9553999901);4ntp(0.9530000091);4nw8(0.9505000114);4nw9(0.9552000165);5v65(0.9519000053);8gjc(0.9523000121) | 4wc8(1);4x0s(0.9671000242) | 4p4v(30) | null | 4p4w(1) | 4wc8(1) | null | null |
4p4y | 2015-05-06 | other | id:A,B,C,D,E,F,G;type:U;source:unknown;length:16;seq_nat:AYLLFYTEAKVTATVK;seq_unnat:(ORN)YLL(PHI)YTE(ORN)KVT(MAA)TVK | 2,046.192 | H 3 2 | 66.260|66.260|154.630|90.00|90.00|120.00 | X-RAY DIFFRACTION | This sequence occurs naturally in humans | R.K. Spencer;A.G. Kreutzer;P.J. Salveson;H. Li;J.S. Nowick | "X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin", J.Am.Chem.Soc., 137, 6304-6311 | 10.1021/jacs.5b01673|25915729||1520-5126|JACSAT | US | Hexamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kvt(maa)tvk | macrocycle;beta-2-microglobulin;hexamer;de novo protein;amyloid | null | null | 4p4v(1) | 4wc8(0.9710999727) | 4p4z(31) | null | 4p4v(1) | 4wc8(0.9710999727) | null | null |
4p4z | 2015-05-06 | other | id:A,B,C,D,E,F,G,H,I,J,K,L;type:U;source:unknown;length:16;seq_nat:AYLLFYTEAKVTVTVK;seq_unnat:(ORN)YLL(PHI)YTE(ORN)KVT(MVA)TVK | 2,074.245 | P 43 21 2 | 63.310|63.310|126.710|90.00|90.00|90.00 | X-RAY DIFFRACTION | This sequence occurs naturally in humans | R.K. Spencer;A.G. Kreutzer;P.J. Salveson;H. Li;J.S. Nowick | "X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin", J.Am.Chem.Soc., 137, 6304-6311 | 10.1021/jacs.5b01673|25915729||1520-5126|JACSAT | US | Octomer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (orn)yll(phi)yte(orn)kvt(mva)tvk | beta-2 microglobulin;octamer;de novo protein;amyloid;beta-sheet | null | null | 7lib(0.9883000255);4p4w(0.9505000114) | null | 4p4y(32) | null | 7lib(0.9883000255) | 4wc8(0.9271000028) | null | null |
4p6j | 2014-12-24 | other | id:A,B;type:U;source:unknown;length:26;seq_nat:YYKEIAHALFSALFALSELYIAVRYX;seq_unnat:Y(4BF)KEIAHALFSALFALSELYIAVRY(NH2) | 3,016.332 | P 43 21 2 | 41.450|41.450|63.990|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | N.H. Joh;T. Wang;M.P. Bhate;R. Acharya;Y. Wu;M. Grabe;M. Hong;G. Grigoryan;W.F. DeGrado | "De novo design of a transmembrane Zn2+-transporting four-helix bundle", Science, 346, 1520-1524 | 10.1126/science.1261172|25525248|0038|1095-9203|SCIEAS | US | Crystal structure of the computationally designed transmembrane metallotransporter with 4-bromophenylalanine in octyl glucoside | 4-bromophenylalanine;transmembrane;transporter;de novo protein;de-novo designed | 4p6k(50);2muz(50);4p6l(50) | null | 4p6l(0.9745000005);2muz(0.9927999973);4p6k(0.9847999811) | null | 4p6k(50) | null | 2muz(0.9927999973) | null | null | null |
4p6k | 2014-12-24 | other | id:A;type:U;source:unknown;length:26;seq_nat:YYKEIAHALFSALFALSELYIAVRYX;seq_unnat:Y(4BF)KEIAHALFSALFALSELYIAVRY(NH2) | 3,016.332 | I 41 2 2 | 46.870|46.870|60.603|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | N.H. Joh;T. Wang;M.P. Bhate;R. Acharya;Y. Wu;M. Grabe;M. Hong;G. Grigoryan;W.F. DeGrado | "De novo design of a transmembrane Zn2+-transporting four-helix bundle", Science, 346, 1520-1524 | 10.1126/science.1261172|25525248|0038|1095-9203|SCIEAS | US | Crystal structure of the computationally designed transmembrane metallotransporter with 4-bromophenylalanine in lipidic cubic phase | transmembrane;lipidic cubic phase;transporter;de novo protein;de-novo designed | 2muz(50);4p6j(50);4p6l(50) | null | 4p6j(0.9857000113);4p6l(0.9826999903);2muz(0.9825999737) | null | 2muz(50) | null | 4p6j(0.9857000113) | null | null | null |
4p6l | 2014-12-24 | other | id:A,B;type:U;source:unknown;length:26;seq_nat:YYKEIAHALFSALFALSELYIAVRYX;seq_unnat:YYKEIAHALFSALFALSELYIAVRY(NH2) | 2,953.436 | I 21 3 | 87.120|87.120|87.120|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | N.H. Joh;T. Wang;M.P. Bhate;R. Acharya;Y. Wu;M. Grabe;M. Hong;G. Grigoryan;W.F. DeGrado | "De novo design of a transmembrane Zn2+-transporting four-helix bundle", Science, 346, 1520-1524 | 10.1126/science.1261172|25525248|0038|1095-9203|SCIEAS | US | Crystal structure of the computationally designed transmembrane metallotransporter in octyl glucoside | transmembrane;de novo protein;transporter;de-novo designed | 4p6k(50);2muz(50);4p6j(50) | null | 4p6k(0.9792000055);2muz(0.9911000133);4p6j(0.9743000269) | null | 4p6k(50) | null | 2muz(0.9911000133) | null | null | null |
4pjq | 2014-12-24 | other | id:A,B;type:U;source:unknown;length:306;seq_nat:GNSVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFE... | 32,857.871 | F 2 3 | 207.543|207.543|207.543|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Coquille;A. Filipovska;T. Chia;L. Rajappa;J.P. Lingford;M.F. Razif;S. Thore;O. Rackham | "An artificial PPR scaffold for programmable RNA recognition", Nat Commun, 5, 5729-5729 | 10.1038/ncomms6729|25517350||2041-1723| | UK | Crystal structure of designed cppr-polyg protein | de novo protein;de novo protein, rna binding protein;rna binding protein;designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions | null | null | null | null | null | null | null | null | null | null |
4pjr | 2014-12-24 | other | id:A;type:U;source:unknown;length:306;seq_nat:GNSVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEM... | 32,919.906 | P 21 21 21 | 54.280|74.930|86.700|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Coquille;A. Filipovska;T. Chia;L. Rajappa;J.P. Lingford;M.F. Razif;S. Thore;O. Rackham | "An artificial PPR scaffold for programmable RNA recognition", Nat Commun, 5, 5729-5729 | 10.1038/ncomms6729|25517350||2041-1723| | UK | Crystal structure of designed cppr-nre protein | rna binding protein;de novo protein, rna binding protein;de novo protein;designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions | null | null | null | null | null | null | null | null | null | null |
4pjs | 2014-12-24 | other | id:A;type:U;source:unknown;length:306;seq_nat:GNSVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPDVVTYTTLISGLGKAGRLEEALELFEEM... | 33,295.066 | P 21 21 21 | 54.880|75.530|86.920|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Coquille;A. Filipovska;T. Chia;L. Rajappa;J.P. Lingford;M.F. Razif;S. Thore;O. Rackham | "An artificial PPR scaffold for programmable RNA recognition", Nat Commun, 5, 5729-5729 | 10.1038/ncomms6729|25517350||2041-1723| | UK | Crystal structure of designed (semet)-cppr-nre protein | rna binding protein;de novo protein, rna binding protein;de novo protein;designer rna-binding proteins; pentatricopeptide repeat; synthetic biology; rna-protein interactions | null | null | null | null | null | null | null | null | null | null |
4pn8 | 2014-10-22 | other | id:A,B,C,D,E,F,G,H,I,J;type:U;source:unknown;length:31;seq_nat:XGKIEQILQKIEKILQKIEWILQKIEQILQG;seq_unnat:(ACE)GKIEQILQKIEKILQKIEWILQKIEQILQG | 3,633.387 | P 1 21 1 | 57.500|55.580|61.400|90.00|106.74|90.00 | X-RAY DIFFRACTION | null | A.R. Thomson;C.W. Wood;A.J. Burton;G.J. Bartlett;R.B. Sessions;R.L. Brady;D.N. Woolfson | "Computational design of water-soluble alpha-helical barrels", Science, 346, 485-488 | 10.1126/science.1257452|25342807|0038|1095-9203|SCIEAS | US | A de novo designed pentameric coiled coil cc-pent | protein design;de novo protein;alpha-helical barrel;coiled coil | null | null | 6q5r(1);6q5q(0.9775999784);3s0r(0.9771999717);5et3(1);5ez9(0.9970999956);5hkn(1);5hkr(0.9990000129);5eza(1);7nfn(1);4pna(1);6eik(0.9575999975);5ezc(1);6zt1(1);5ez8(0.9578999877);5eze(0.9578999877);7nfk(0.9575999975);8b15(0.9550999999);8b16(0.9578999877);6xy1(1);7nfp(1);6q5s(1);5vte(0.9557999969) | null | 4pn8(0) | null | 6q5r(1) | null | 6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;1.20.5.470;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.950;6.10.250.850... | null |
4pn9 | 2014-10-22 | other | id:A,B,C,D,E,F;type:U;source:unknown;length:31;seq_nat:XGEIAKSLKEIAKSLKEIAWSLKEIAKSLKG;seq_unnat:(ACE)GEIAKSLKEIAKSLKEIAWSLKEIAKSLKG | 3,302.965 | C 2 2 21 | 59.320|125.530|58.150|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A.R. Thomson;C.W. Wood;A.J. Burton;G.J. Bartlett;R.B. Sessions;R.L. Brady;D.N. Woolfson | "Computational design of water-soluble alpha-helical barrels", Science, 346, 485-488 | 10.1126/science.1257452|25342807|0038|1095-9203|SCIEAS | US | A de novo designed hexameric coiled coil cc-hex2 | protein design;de novo protein;alpha-helical barrel;coiled coil | null | null | 6eiz(1);8a09(1);8b16(1);7bas(1);7bav(1);8b15(0.9958000183);7bim(1);7a1t(1);6g6d(0.9970999956);6xy1(1);7nfg(1);4pna(1);6yb2(1);7nfo(1);7nff(0.9933000207);7nfj(0.9987999797);5ez8(1);7nfi(0.9979000092);7nfl(1);7nfm(0.9975000024);7qwa(1);7qwd(1);7qwe(1);5ez9(1);6g6f(1);6g6g(1);7bat(1);7qwb(1);7baw(1);7nfh(1);5eza(0.9987999... | null | 4pn9(0) | null | 6eiz(1) | null | 6.10.250.1960;6.10.250.1110;1.20.5.510;6.10.250.2050;4.10.180.60;6.10.250.400;6.10.250.1200;1.20.5.460;4.10.180.10;6.10.250.2830;6.10.250.310;6.10.250.1560;6.10.250.3210;1.20.5.220;1.20.5.640 | null |
4pna | 2014-10-22 | other | id:A,B,C,D,E,F,G;type:U;source:unknown;length:31;seq_nat:XGEIAQALKEIAKALKEIAWALKEIAQALKG;seq_unnat:(ACE)GEIAQALKEIAKALKEIAWALKEIAQALKG | 3,236.863 | P 2 21 21 | 38.530|48.740|129.310|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A.R. Thomson;C.W. Wood;A.J. Burton;G.J. Bartlett;R.B. Sessions;R.L. Brady;D.N. Woolfson | "Computational design of water-soluble alpha-helical barrels", Science, 346, 485-488 | 10.1126/science.1257452|25342807|0038|1095-9203|SCIEAS | US | A de novo designed heptameric coiled coil cc-hept | protein design;de novo protein;alpha-helical barrel;coiled coil | null | null | 7bim(1);6xy1(1);5ez8(1);7nff(1);7nfi(1);7nfj(1);7nfl(1);7nfm(1);8a09(1);4pn9(1);6eiz(1);7nfk(1);7nfo(1);8b16(1);7nfg(1);5ez9(1);6zt1(1);7a1t(1);6eik(1);8b15(0.9947000146);5eza(1);6g6e(1);6yb2(1);7bas(1);7bav(1);7nfn(1);7qwa(1);7qwd(1);7qwe(1);5ezc(1);6g6g(1);7qwb(1);6g6f(1);7nfh(1);7nfp(1);5eze(1);6xxz(1);6xy0(1);6yaz(... | null | 4pna(0) | null | 7bim(1) | null | 1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.770;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.2150;6.10.250.200;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.490;6.10.250.380;1.20.5.110;1... | null |
4pnb | 2014-10-22 | other | id:A,B,C,D;type:U;source:unknown;length:31;seq_nat:XGEIAQSIKEIAKSIKEIAWSIKEIAQSIKG;seq_unnat:(ACE)GEIAQSIKEIAKSIKEIAWSIKEIAQSIKG | 3,300.863 | I 21 3 | 89.210|89.210|89.210|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A.R. Thomson;C.W. Wood;A.J. Burton;G.J. Bartlett;R.B. Sessions;R.L. Brady;D.N. Woolfson | "Computational design of water-soluble alpha-helical barrels", Science, 346, 485-488 | 10.1126/science.1257452|25342807|0038|1095-9203|SCIEAS | US | A de novo designed hexameric coiled coil cc-hex3 | protein design;peptide;alpha-helical barrel;de novo protein;artificially designed - often synthetic;coiled coil | null | null | null | null | null | null | null | null | null | null |
4pnd | 2014-10-22 | other | id:A,B,C,D,E;type:U;source:unknown;length:31;seq_nat:XGNILQKIENILKKIENILWKIENILQKIEG;seq_unnat:(ACE)GNILQKIENILKKIENILWKIENILQKIEG | 3,577.283 | P 21 21 21 | 31.950|42.560|97.000|90.00|90.00|90.00 | X-RAY DIFFRACTION | The molecule was synthesised using solid phase peptide synthesis | A.R. Thomson;C.W. Wood;A.J. Burton;G.J. Bartlett;R.B. Sessions;R.L. Brady;D.N. Woolfson | "Computational design of water-soluble alpha-helical barrels", Science, 346, 485-488 | 10.1126/science.1257452|25342807|0038|1095-9203|SCIEAS | US | A de novo designed pentameric coiled coil cc-pent_variant | protein design;alpha-helical barrel;de novo protein;artificially designed - often synthetic;coiled coil | null | null | 6xy0(0.9779000282);6xy1(0.9894000292) | null | 4pnd(0) | null | 6xy1(0.9894000292) | null | 6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.2620;1.20.5.1450;6.10.250.1140;1.20.5.700;6.10.250.500;6.10.250.1150;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.20.5.3960;6.10.250.2370;6.10.250.1210;1.20.5.470;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.16... | null |
4pq8 | 2014-03-12 | other | id:A;type:D;source:SYNTHETIC CONSTRUCT;length:274;seq_nat:MGHHHHHHTITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQSLPTGVDEKLTQL... | 30,077.736 | P 43 | 72.914|72.914|51.326|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;F. Parmeggiani;J. Seetharaman;H. Janjua;R. Xiao;M. Maglaqui;K. Park;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J. Hunt | To be published | |||| | null | Crystal structure of engineered protein, northeast structural genomics consortium target or465 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;de novo protein;nesg | 4r5d(461);4psj(460);4r6g(426);4r5c(422);4r6j(408);4r6f(366);4r58(223) | 3rfj(322);3rfs(320);4j4l(310);1oto(198);1otm(195);1otn(192);1m9s(189);1d0b(188);2uzx(184);2uzy(184);2wqu(184);2wqv(184);1h6t(184);2y5q(184);2wqx(183);2wqw(178);4aw4(174);2o6q(168);3m18(158);3m19(158);2o6s(145);3wo9(141);2omv(139);2omw(139);2omy(139);2omx(139);1o6v(139);2omz(139);1o6s(139);1o6t(139);2omt(138);2omu(138);... | 4psj(0.9825999737);4r5d(0.9850000143) | null | 4r5d(461) | 3rfj(322) | 4r5d(0.9850000143) | 3rfj(0.9180999994) | 2.160.20.130;3.80.10.10;2.160.20.110;1.10.8.390;2.160.20.10;3.80.20.20;2.160.20.80;2.160.20.70;3.40.50.12480 | null |
4psj | 2014-03-26 | other | id:A;type:D;source:synthetic construct;length:274;seq_nat:MGHHHHHHTITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQINANNSDIKSVQGIQYLPNVRQLNLGGNKLHDISALKELTNLGWLNLSSNKIEKLPQGLFESLTTLTQLNLSNNQITSLPQGLFESLASLTQLNLSNNQITSLPQGLFESLTNLTQLNLSNNQITSLPQGLFESLTNLTQLNLSNNQITSLPQGLFESLTSLTQLNLSNNQITSLPQGLFESLTNLKQLNLSGNQIQSLPQGLHESLTQL... | 29,894.361 | P 1 21 1 | 31.916|51.455|69.005|90.000|90.980|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;F. Parmeggiani;J. Seetharaman;P.-S. Huang;H. Janjua;R. Xiao;M. Maglaqui;K. Park;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J. Hunt | To be published | |||| | null | Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or464 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;or464;de novo protein;nesg;engineered protein | 4pq8(463);4r5d(402);4r6g(371);4r5c(369);4r6j(359);4r6f(326);4r58(212) | 3rfj(298);3rfs(293);4j4l(283);1oto(196);1otm(193);1otn(190);1m9s(187);1d0b(186);2uzx(183);2uzy(183);2wqu(183);2wqv(183);1h6t(182);2y5q(182);2wqw(177);2wqx(177);4aw4(174);2o6q(157);2omx(149);2omt(147);2omu(147);2omv(145);2omw(145);2omy(145);1o6v(142);2omz(142);1o6s(142);1o6t(142);3m19(141);3m18(140);4bv4(139);3wo9(136);... | 4pq8(0.9649000168);4r5d(0.9538000226) | null | 4pq8(463) | 3rfj(298) | 4pq8(0.9649000168) | 3rfs(0.8381999731) | 2.160.20.130;3.80.10.10;3.80.20.20;2.160.20.80;2.160.20.70 | null |
4pww | 2014-04-09 | other | id:A;type:D;source:synthetic construct;length:90;seq_nat:MEMDIRFRGDDLEALLKAAIEMIKQALKFGATITLSLDGNDLEIRITGVPEQVRKELAKEAERLAKEFGITVTRTIRGSWSLEHHHHHH;seq_unnat:MEMDIRFRGDDLEALLKAAIEMIKQALKFGATITLSLDGNDLEIRITGVPEQVRKELAKEAERLAKEFGITVTRTIRGSWSLEHHHHHH | 10,190.724 | I 21 21 21 | 33.548|69.645|73.138|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;Y.-R. Lin;J. Seetharaman;R. Xiao;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt | To be published | |||| | null | Crystal structure of engineered protein. northeast structural genomics consortium target or494 | de novo;northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;or494;de novo protein;nesg | 2mtl(141);4rjv(135);2kl8(134);9qud(134);9qui(134);9quc(134);6zv9(134);6wxp(134);6wxo(134);9qul(132);9quo(132);4ky3(121);4kyz(121);4nez(104);4ney(104);5cw9(100);9qup(61) | 4hhu(104) | null | null | 2mtl(141) | 4hhu(104) | 6wxo(0.8583999872) | 4hhu(0.8015999794) | 3.30.70.260 | null |
4qfv | 2015-05-06 | other | id:A,B,C,D;type:U;source:unknown;length:236;seq_nat:MSMDIGKKLLEAARAGHDDSVEVLLKKGADINAKDNSGRTPLHVAALNGHLELVKLLLEKGADINARDMFGLTPLHTAASNGHLELVKLLLEKGADINARDEDGSTPLHLAASNGHLELVKLLLEKGADINAEDHSGTTPLHFAAKNGHLELVKLLLEKGADINASDFSGPTPLHSAAENGHLELVKLLLEKGADINARDKFGKTPFDLAIDNGNEDIAEVLQKAARSHHHHHH;seq_unnat:MSMDIGKKLLEAARAGHDDSVEV... | 25,111.428 | P 1 21 1 | 66.669|92.748|69.636|90.00|91.39|90.00 | X-RAY DIFFRACTION | Synthetic construct | E.B. Tikhonova;A.S. Ethayathulla;Y. Su;P. Hariharan;S. Xie;L. Guan | "A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen", Sci Rep, 5, 8070-8070 | 10.1038/srep08070|25627011||2045-2322| | UK | Crystal structure of a unique ankyrin | de novo protein;designed ankyrin repeats;domain swap | 4o60(419);5le9(279);5lea(278);5le3(271);5le6(268);5le4(268);5le7(268);5le8(265);5leb(262);5lee(259);5led(259);5lec(259);5le2(258);7ujj(246);7qnl(240);7tbq(240);7tbn(235);7tcd(235);7z71(214);2xee(211);7b4t(210);4gpm(208);4hqd(207);8a19(207);6fpa(206);6fpb(206);4hb5(206);7b4w(205);7z7c(205);9gtk(205);6fp9(205);8v9o(205);... | 4k5a(212);4hll(209);4hrm(207);4k5b(201);4hrl(201);3noc(199);2y1l(198);3zu7(197);2p2c(196);2v5q(195);2bkk(194);1svx(194);4f6r(194);4hna(194);3nog(193);4k5c(193);4dx6(190);4u96(190);4dx7(190);4u8v(190);9fhc(190);4u8y(190);2j8s(190);4lsz(190);4ydy(190);9fhg(190);9fhj(190);9hao(190);4c48(190);9hci(190);4dx5(190);4u95(190);... | null | null | 4o60(419) | 4k5a(212) | 4o60(0.9302999973) | 4k5b(0.9136000276) | 1.25.40.290;1.25.40.750;1.10.10.2400;1.25.40.70;1.10.220.10;1.25.40.720;1.25.60.10;1.25.40.580;1.25.10.10;1.25.40.180;1.25.40.10;1.25.40.320;1.25.40.1040;1.25.40.350;1.25.40.20 | null |
4qkr | 2015-01-14 | other | id:A;type:D;source:Synthetic;length:133;seq_nat:HHHHHHEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPEGNGEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPEGNGEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPEGNG;seq_unnat:HHHHHHEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPEGNGEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPEGNGEVLLRSTETGQYLRINPDGTVDGTRDRSDPGIQYQISPE... | 14,622.649 | P 21 21 21 | 34.763|46.792|67.648|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | L.M. Longo;C.A. Tenorio;O.S. Kumru;C.R. Middaugh;M. Blaber | "A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding", Protein Sci., 24, 27-37 | 10.1002/pro.2580|25297559|0795|0961-8368|PRCIEI | US | Crystal structure of 6xtyr/pv2: de novo designed beta-trefoil architecture with symmetric primary structure (l22y/l44y/l64y/l85y/l108y/l132y, primitive version 2) | prebiotic protein;de novo protein;beta-trefoil;simplified protein design | 4qks(272);4d8h(263);3o4d(259);3o4b(248);3o4c(246);3o4a(240);3o49(236);4ow4(188);3ogf(183);3ol0(100) | 4f34(233);3snv(232);3o3q(100);1nzk(93);1m16(92);1q03(91);1jt7(90);3fgm(89);1jtc(89);3fjd(89);1pzz(89);2hwm(89);2hz9(89);3fji(89);3bao(89);3fjc(88);1jt3(88);1jt5(88);3baq(87);3fj8(87);1k5u(87);3fj9(87);3fja(87);1k5v(87);2hw9(87);3b9u(87);2hwa(87);3bau(87);3bag(87);3fje(87);2ntd(87);3bah(87);3fjf(87);1q04(87);3fjh(87);1j... | 3q7w(0.9657999873);3q7x(0.9588999748) | null | 4qks(272) | 4f34(233) | 3q7w(0.9657999873) | 4f34(0.9358000159) | 2.80.10.50 | null |
4qks | 2015-01-14 | other | id:A;type:D;source:Synthetic;length:133;seq_nat:HHHHHHEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPEGNGEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPEGNGEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPEGNG;seq_unnat:HHHHHHEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPEGNGEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPEGNGEVLLRSTETGQWLRINPDGTVDGTRDRSDPGIQWQISPE... | 14,760.864 | P 21 21 21 | 47.138|48.471|69.691|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | L.M. Longo;C.A. Tenorio;O.S. Kumru;C.R. Middaugh;M. Blaber | "A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding", Protein Sci., 24, 27-37 | 10.1002/pro.2580|25297559|0795|0961-8368|PRCIEI | US | Crystal structure of 6xtrp/pv2: de novo designed beta-trefoil architecture with symmetric primary structure (l22w/l44w/l64w/l85w/l108w/l132w his primitive version 2) | prebiotic protein;de novo protein;beta-trefoil;simplified protein design | 4qkr(272);4d8h(261);3o4d(251);3o4b(239);3o4c(238);3o4a(232);3o49(228);4ow4(181);3ogf(178);3ol0(97) | 4f34(224);3snv(224);3o3q(94);3fjc(89);1nzk(88);1jt7(87);1q03(87);1m16(87);1pzz(86);3bao(86);3fgm(85);1jtc(85);3fjd(85);2hwm(85);2hz9(85);3fji(85);1jt3(85);1jt5(85);3baq(84);3b9u(84);2hwa(84);3bau(84);3fje(84);1q04(84);3fjh(84);3crg(84);3crh(84);3ba4(84);3cri(84);2aqz(83);3fj8(83);1k5u(83);3fj9(83);3fja(83);1k5v(83);3fj... | 3q7w(0.9659000039);4d8h(0.970600009);3q7x(0.9682999849);4qkr(0.9595000148) | null | 4qkr(272) | 4f34(224) | 4d8h(0.970600009) | 4f34(0.9178000093) | 2.80.10.50 | null |
4qtr | 2015-07-29 | other | id:A,B,C,D;type:N;source:Drosophila melanogaster;length:72;seq_nat:MEKRPRTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKSTGGSGGHHHHHH;seq_unnat:MEKRPRTAFSEEQKKALDLAFYFDRYLTPEWRRYLSQRLGLNEAQIKIWFQNKRAKIKKSTGGSGGHHHHHH|id:E,G;type:U;source:unknown;length:16;seq_nat:GTGTAATTTAATTTCC;seq_unnat:(DG)(DT)(DG)(DT)(DA)(DA... | 8,683.909 | P 42 2 2 | 90.098|90.098|158.923|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | Y. Mou;J.Y. Yu;T.M. Wannier;C.L. Guo;S.L. Mayo | "Computational design of co-assembling protein-DNA nanowires", Nature, 525, 230-233 | 10.1038/nature14874|26331548|0006|0028-0836|NATUAS | UK | Computational design of co-assembling protein-dna nanowires | dna-binding protein;de novo design-dna complex;double-stranded dna;helix-turn-helix;de novo design/dna | null | null | null | null | null | null | null | null | null | null |
4r58 | 2015-01-14 | other | id:A,B,C,D;type:D;source:synthetic construct;length:222;seq_nat:ETITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNLKTLKLSNNKITDISALKQLNNLGWLDLSNNGITDISALKNLASLHTLDLSNNGITDISALKNLDNLHTLDLSNNGITDISALKNLDNLHTLDLSNNGITDISALKNLTSLHTLDLSNNGITDISALKNLDNLETLDLRNNGITDKSALKNLNNLK;seq_unnat:ETITVSTPIKQIFPDDAFAETIKAN... | 23,898.801 | P 1 21 1 | 57.583|145.006|57.700|90.00|115.35|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computational designed leucine rich repeats dlrr_a in space group p21 | de novo protein;leucine rich repeat (lrr) protein | 4r5c(314);4r6j(226);4pq8(226);4r6f(224);4r5d(224);4r6g(224);4psj(214) | 1oto(245);1otm(242);4aw4(241);1m9s(241);1d0b(240);1otn(239);2uzx(237);2uzy(237);2wqu(237);2wqv(237);1h6t(236);2y5q(236);2wqw(230);2wqx(230);2omt(179);2omu(179);2omx(179);3rfj(178);3rfs(177);2omv(177);2omw(177);2omy(177);1o6v(175);2omz(175);1o6s(175);1o6t(175);4fho(168);4fmz(167);4j4l(164);1h6u(162);8qp7(147);4cil(145);... | null | 4aw4(0.9502999783);2omu(0.9623000026);2omx(0.9627000093) | 4r5c(314) | 1oto(245) | 4pq8(0.869599998) | 2omx(0.9627000093) | 2.160.20.130;3.80.10.10;1.10.8.390;2.160.20.10;3.80.20.20;2.160.20.80;2.160.20.70;3.40.50.12480 | null |
4r5c | 2015-01-07 | other | id:A;type:D;source:synthetic construct;length:307;seq_nat:TITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTSLHTLDLSNNGITDISALKNLDNLHTLDLSNNGITDISALKNLDNLHTLDLSNNGITD... | 33,239.156 | P 21 21 21 | 32.137|77.707|101.889|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computational designed leucine rich repeats dlrr_e in space group of p212121 | de novo protein;leucine rich repeat (lrr) protein | 4r5d(450);4pq8(423);4r6g(413);4r6f(391);4psj(369);4r6j(359);4r58(313) | 3rfs(319);3rfj(319);4j4l(308);1oto(201);1otm(198);1m9s(196);1d0b(195);1otn(194);4aw4(193);2uzx(192);2uzy(192);2wqu(192);2wqv(192);1h6t(192);2y5q(192);2wqx(191);2wqw(186);4fmz(177);2omv(176);2omw(176);2omy(176);2omx(176);1o6v(176);2omz(176);1o6s(176);1o6t(176);2omt(175);2omu(175);3m18(155);3m19(154);2o6q(150);2o6s(145);... | null | null | 4r5d(450) | 3rfs(319) | 4psj(0.9054999948) | 3rfj(0.9021000266) | 3.80.10.10;2.160.20.160;1.25.10.10;2.160.20.80;2.160.20.70 | null |
4r5d | 2015-01-07 | other | id:A;type:D;source:synthetic construct;length:446;seq_nat:ATITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTSLTTLNLSNNQLTSLPDGVFERLTNLKTLNLSNNQLTKEACRAVANALKQAASLHEL... | 48,008.77 | F 2 2 2 | 91.134|136.384|161.753|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computational designed leucine rich repeats dlrr_g3 in space group f222 | de novo protein;leucine rich repeat (lrr) protein | 4r6g(693);4pq8(461);4r5c(445);4psj(400);4r6j(396);4r6f(379);4r58(223) | 3rfj(322);3rfs(319);4j4l(308);1oto(193);1otm(190);1dfj(190);2bnh(190);1d0b(188);1m9s(188);1otn(187);2uzx(184);2uzy(184);2wqu(184);2wqv(184);1h6t(184);2y5q(184);2wqx(182);4peq(182);2wqw(178);4aw4(173);3tsr(173);1a4y(167);2bex(167);2q4g(167);1z7x(167);2o6q(166);4per(163);3m18(159);3m19(159);2o6s(147);3wo9(140);2omv(139);... | null | null | 4r6g(693) | 3rfj(322) | 4pq8(0.9333999753) | 3rfs(0.8288999796) | 2.160.20.130;3.80.10.10;2.160.20.10;1.25.40.10;3.80.20.20;3.40.50.10910;3.30.750.24;2.160.20.80;2.160.20.70;3.30.750.70;3.40.50.12480 | null |
4r6f | 2015-01-07 | other | id:A;type:D;source:synthetic construct;length:335;seq_nat:ATITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPI... | 36,529.043 | C 1 2 1 | 109.135|42.571|67.607|90.00|102.14|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computational designed protein dlrr_i | de novo protein;leucine rich motifs | 4r6g(530);4r6j(446);4r5c(387);4r5d(381);4pq8(367);4psj(325);4r58(221) | 3rfs(267);3rfj(265);4j4l(256);8yht(197);8yhu(197);1ziw(197);3ulv(197);3ulu(197);2a0z(197);1oto(188);1otm(184);1m9s(183);1d0b(182);1otn(181);2uzx(179);2uzy(179);2wqu(179);2wqv(179);1h6t(179);2y5q(179);2wqx(175);3cig(175);3ciy(175);4aw4(172);2wqw(170);2omx(152);2omv(151);2omw(151);2omy(151);2omt(150);2omu(150);1o6v(148);... | null | null | 4r6g(530) | 3rfs(267) | 4r6g(0.9229000211) | 3rfs(0.8396000266) | 3.80.10.10;2.160.20.80;3.40.50.12480 | null |
4r6g | 2015-01-07 | other | id:A;type:D;source:synthetic construct;length:469;seq_nat:TITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNLANLNDRVFEGLTNLTTLNLSNNNLARLWKHANPGGPIYFLKGLTNLTTLNLSNNGFDELPKEVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLTTLNLSNNQLTSLPQGVFERLTNL... | 50,876.094 | P 2 21 21 | 36.868|93.369|126.237|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computational designed leucine rich repeats dlrr_k in space group p22121 | de novo protein;leucine rich motifs | 4r5d(695);4r6f(534);4r6j(487);4pq8(431);4r5c(410);4psj(373);4r58(221) | 3rfj(288);3rfs(286);4j4l(274);1oto(188);1otm(185);1d0b(183);1m9s(183);1otn(182);2uzx(179);2uzy(179);2wqu(179);2wqv(179);1h6t(179);2y5q(179);2wqx(175);2wqw(170);4aw4(168);8yht(166);8yhu(166);1ziw(166);3ulv(166);3ulu(166);2a0z(166);2omx(164);2omv(162);2omw(162);2omy(162);2omt(162);2omu(162);1o6v(159);2omz(159);1o6s(159);... | null | null | 4r5d(695) | 3rfj(288) | 4r6j(0.8949000239) | 1d0b(0.7975999713) | 3.80.10.10;3.40.50.12820;3.30.110.150;3.30.750.24;2.160.20.80;3.30.750.70;3.40.50.12480 | null |
4r6j | 2015-01-07 | other | id:A,B,C,D;type:D;source:synthetic construct;length:257;seq_nat:TITVSTPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNLANLNDKVFEGLTNLTTLNLSNNNLARLWKHANPGGPIYFLKGLTNLTTLNLSNNGFDEFPKEVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQSLPTA;s... | 27,996.521 | P 21 21 21 | 89.775|96.498|136.345|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | K. Park;B.W. Shen;F. Parmeggiani;P.S. Huang;B.L. Stoddard;D. Baker | "Control of repeat-protein curvature by computational protein design", Nat.Struct.Mol.Biol., 22, 167-174 | 10.1038/nsmb.2938|25580576||1545-9993| | US | Crystal structure of computaional designed lucine rich repeats dlrr_h in space group p212121 | leucine rich repeats;de novo protein | 4r6g(486);4r6f(446);4pq8(409);4r5d(396);4psj(358);4r5c(358);4r58(222) | 3rfs(280);3rfj(280);4j4l(271);1oto(186);1otm(183);1m9s(182);1d0b(181);1otn(180);2uzx(178);2uzy(178);2wqu(178);2wqv(178);1h6t(177);2y5q(177);2wqx(173);2wqw(169);4aw4(167);8yht(158);8yhu(158);1ziw(158);3ulv(158);3ulu(158);2a0z(158);3cig(141);3ciy(141);2omv(132);2omw(132);2omy(132);2omx(131);2omt(129);2omu(129);2o6q(128);... | 4r6g(0.9523000121) | null | 4r6g(486) | 3rfs(280) | 4r6g(0.9523000121) | 3rfs(0.8384000063) | 2.160.20.130;3.80.10.10;1.10.8.390;2.160.20.10;3.10.350.10;3.80.20.20;2.160.20.80;2.160.20.70 | null |
4r80 | 2014-09-24 | other | id:A,B;type:D;source:synthetic construct;length:86;seq_nat:MPSEEEEKRRAKQVAKEKILEQNPSSKVQVRRVQKQGNTIRVELEITENGKKTNITVEVEKQGNTFTVKRITETVGSLEHHHHHH;seq_unnat:MPSEEEEKRRAKQVAKEKILEQNPSSKVQVRRVQKQGNTIRVELEITENGKKTNITVEVEKQGNTFTVKRITETVGSLEHHHHHH | 9,897.169 | C 1 2 1 | 56.139|70.619|41.040|90.000|113.160|90.000 | X-RAY DIFFRACTION | null | null | To be published | |||| | null | Crystal structure of a de novo designed beta sheet protein, cystatin fold, northeast structural genomics consortium (nesg) target or486 | cystatin fold;protein structure initiative;denovo beta sheet design;northeast structural genomics consortium (nesg);structural genomics;psi-biology;protein engineering;de novo protein;target or486 | 5kph(136) | null | null | null | 5kph(136) | null | 5kph(0.7972999811) | 3fka(0.6424000263) | 3.10.450.130;3.30.360.60;3.30.360.10;3.30.310.80;3.30.360.40;3.30.160.40;3.30.300.20;3.10.450.520;3.10.450.20;3.10.450.40;3.30.360.90;3.10.450.560;3.10.450.10;3.30.200.150;3.10.450.360;3.30.200.70;3.10.450.380;3.30.200.20 | null |
4rjv | 2014-10-22 | other | id:A,B,C,D;type:D;source:synthetic construct;length:88;seq_nat:MEMDIRFRGDDDEALARALLKMVVRAVSFGAQVRFTDDGNDLEIRITGVPEQVLKELAKEAERLAKEFGITVTRTIRGSLEHHHHHH;seq_unnat:MEMDIRFRGDDDEALARALLKMVVRAVSFGAQVRFTDDGNDLEIRITGVPEQVLKELAKEAERLAKEFGITVTRTIRGSLEHHHHHH | 9,951.331 | P 1 | 37.666|46.688|48.066|86.490|72.890|72.330 | X-RAY DIFFRACTION | null | null | To be published | |||| | null | Crystal structure of a de novo designed ferredoxin fold, northeast structural genomics consortium (nesg) target or461 | northeast structural genomics consortium (nesg) target or461;protein structure initiative;structural genomics;psi-biology;ferredoxin fold;de novo protein | 4pww(137);2mtl(129);2kl8(119);4ky3(114);4kyz(114);9qul(103);9quo(103);9qud(103);9qui(103);9quc(103);6zv9(103);6wxp(103);6wxo(103);4nez(92);4ney(92);5cw9(87);9qup(54) | 4hhu(91) | null | null | 4pww(137) | 4hhu(91) | 4ney(0.8544999957) | 4hhu(0.8630999923) | 3.30.70.1140;3.30.70.790;3.30.70.2860;3.30.70.1650;3.30.70.2250;3.30.70.1430;3.30.70.80;3.30.70.2810;3.30.70.870;3.30.70.1280;3.30.70.1520;3.30.70.250;3.30.70.860;3.30.70.930;3.30.70.240;3.30.70.600;3.30.70.2280;3.30.70.1440;3.30.70.1750;3.30.70.2940;3.30.70.1130;3.30.70.340;3.30.70.330;3.30.70.1940;3.30.70.1170;3.30.7... | null |
4rv1 | 2014-12-10 | other | id:A,B,C,D,E,F;type:D;source:SYNTHETIC CONSTRUCT;length:425;seq_nat:MNDVEKLVKLLTSTDSETQKEAARDLAEIASGPASAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPTSAIKAIVDAGGVEVLVKLLTSTDSEVQKEAARALANIASGPDEAIKAIVD... | 42,917.348 | P 32 2 1 | 99.265|99.265|432.183|90.000|90.000|120.000 | X-RAY DIFFRACTION | null | S. Vorobiev;F. Parmeggiani;J. Seetharaman;R. Xiao;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt | To be published | |||| | null | Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or497 | northeast structural genomics consortium;protein structure initiative;or497;structural genomics;psi-biology;de novo protein;nesg;engineered protein | 4hxt(437);4rzp(325);7r0r(206);7qnp(200) | 1ial(183);3tpm(182);2c1m(182);3ve6(182);3l3q(182);3btr(182);1y2a(182);3zir(182);2ynr(182);3zin(182);3zio(182);3zip(182);3ziq(182);1ejl(181);3knd(181);1ejy(181);1pjm(181);1iq1(181);1pjn(181);4oih(181);3q5u(181);1q1s(181);1q1t(181);4htv(181);4mz5(181);4mz6(181);3ukw(181);3ukx(181);3uky(181);3ukz(181);3ul0(181);3ul1(181);... | null | null | 4hxt(437) | 1ial(183) | 4hxt(0.9100000262) | 1bk5(0.7633000016) | 1.25.40.250;1.20.930.10;1.20.58.1280;1.20.970.10;1.10.10.1630;1.25.40.90;1.25.10.10;1.25.40.420;1.20.1050.10;1.20.58.1150;1.25.40.750;1.25.40.40;1.25.40.70;1.25.40.580;1.20.58.930;1.10.220.100;1.20.1660.10;1.20.50.20;1.25.40.850;1.25.40.290;1.20.58.80;1.25.40.450;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.... | null |
4rzp | 2015-01-07 | other | id:A,B;type:D;source:synthetic construct;length:255;seq_nat:MNDLEKLVELLTHDDSKTQQEAARDLAEIASGNASAIKQVIDAGALEKLVELLTHDDSKVQQEAARALANIASGNDEAIKQVIDAGALEKLVELLTHDDSKVQQEAARALANIASGNDEAIKQVIDAGALEKLVELLTHDDSKVQQEAARALANIASGNDEAIKQVIDAGALEKLVELLTHDDSKVQQEAARALANIASGNTSAIKQVIDAGALEKLQELLTHDDSKVQQEAQRALENIKSGGWLEHHHHHH;seq_unn... | 27,085.047 | P 21 21 21 | 62.718|81.256|97.222|90.000|90.000|90.000 | X-RAY DIFFRACTION | null | S. Vorobiev;F. Parmeggiani;F. Dimaio;J. Seetharaman;S. Sahdev;R. Xiao;S. Kogan;J.K. Everett;T.B. Acton;D. Baker;G.T. Montelione;L. Tong;J.F. Hunt | To be published | |||| | null | Crystal structure of engineered protein. northeast structural genomics consortium (nesg) target or366 | northeast structural genomics consortium;protein structure initiative;structural genomics;psi-biology;or366;de novo protein;nesg;engineered protein | 4hxt(338);4rv1(323);7r0r(216);7qnp(213) | 4b18(130);3tj3(130);2jdq(130);1ee4(126);1ee5(126);1un0(126);2c1t(126);3tpm(125);1bk5(125);1bk6(125);2c1m(125);3ve6(125);3l3q(125);3btr(125);1y2a(125);1ial(125);3zir(125);2ynr(125);3zin(125);3zio(125);3zip(125);3ziq(125);1wa5(125);4bqk(124);1ejl(124);3knd(124);1ejy(124);1pjm(124);1iq1(124);1pjn(124);4oih(124);3q5u(124);... | null | null | 4hxt(338) | 4b18(130) | 4hxt(0.8975999951) | 4pls(0.8504999876) | 1.25.40.300;1.25.40.250;1.20.930.10;1.20.190.60;1.10.10.1630;1.20.970.10;1.25.40.90;1.25.10.10;1.25.40.420;1.25.40.550;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;6.10.140.1030;1.10.1240.10;1.25.40.580;1.10.220.100;1.20.50.20;1.25.40.290;1.10.10.2400;1.25.40.450;1.25.60.10;1.25.40.10;1.10.1240.70;1.25.40.320;1.20.58.... | null |
4tql | 2014-10-15 | other | id:A,B;type:D;source:synthetic construct;length:250;seq_nat:NEDDMKKLYKQMVQELEKARDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGDKQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDGDDELLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKGLEHHHHHH;seq_unnat:NE... | 29,898.969 | P 1 | 24.877|41.547|133.202|98.94|92.25|90.06 | X-RAY DIFFRACTION | null | P.S. Huang;G. Oberdorfer;C. Xu;X.Y. Pei;B.L. Nannenga;J.M. Rogers;F. DiMaio;T. Gonen;B. Luisi;D. Baker | "High thermodynamic stability of parametrically designed helical bundles", Science, 346, 481-485 | 10.1126/science.1257481|25342806|0038|1095-9203|SCIEAS | US | Computationally designed three helix bundle | de novo protein;helical bundle | null | null | null | null | 8fbj(49) | null | 8h7d(0.568599999) | 2d1l(0.533100009) | 6.10.140.1860;1.10.287.1490;1.10.287.80;1.20.120.30;1.10.287.620;1.20.120.570;1.20.1230.10;1.20.1050.20;1.20.58.1250;1.20.58.120;1.20.58.70;1.10.287.1700 | null |
4u3h | 2015-02-11 | other | id:A;type:U;source:unknown;length:101;seq_nat:MHHHHHHLVPRGSPSPPGNLRVTDVTSTSVTLSWEPPPGPITGYRVEYREAGGEWKEVTVPGSETSYTVTGLKPGTEYEFRVRAVNGAGEGPPSSVSVTT;seq_unnat:MHHHHHHLVPRGSPSPPGNLRVTDVTSTSVTLSWEPPPGPITGYRVEYREAGGEWKEVTVPGSETSYTVTGLKPGTEYEFRVRAVNGAGEGPPSSVSVTT | 10,759.838 | P 41 3 2 | 86.100|86.100|86.100|90.00|90.00|90.00 | X-RAY DIFFRACTION | This sequence was generated through consensus design | B.T. Porebski;A.A. Nickson;D.E. Hoke;M.R. Hunter;L. Zhu;S. McGowan;G.I. Webb;A.M. Buckle | "Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain", Protein Eng.Des.Sel., 28, 67-78 | 10.1093/protein/gzv002|25691761||1741-0134| | UK | Crystal structure of fn3con | protein stability;fibronectin type iii;consensus design;de novo protein;fn3 | 4m6a(74);4lpu(73);4lpt(68);4lpv(67);4lpy(67);4lpw(66);4lpx(66);5l2h(66);9f00(52);3qht(50) | 3teu(79);3tes(74);4lxo(74);1ttf(72);1ttg(72);4mmx(72);1mfn(72);2mfn(72);1fnf(72);2dju(71);1fna(70);2ck2(70);2ocf(68);2gee(68);1uem(66);4mmz(65);4o00(65);4mmy(64);3b83(64);2ed9(64);3lpw(64);2cum(63);1x5g(63);1x5h(62);1fnh(62);1tdq(62);3r8q(62);3t1w(62);4pbx(62);1uen(61);3ch8(61);2xyc(61);2jll(61);2doc(60);1x4z(60);2edy(... | null | null | 4m6a(74) | 3teu(79) | 5l2h(0.8130999804) | 2ck2(0.8436999917) | 2.60.40.2920;2.60.40.1940;2.60.40.1230;2.60.40.3920;2.60.40.3340;2.60.40.380;2.60.40.3760;2.60.40.10;2.60.40.350;2.60.40.3880;2.60.40.60;2.60.40.2030;2.60.40.290;2.60.40.3020;2.60.40.2420;2.60.40.1200;2.60.40.1220;2.60.40.3780;2.60.40.1930 | null |
4uos | 2014-11-05 | other | id:A;type:D;source:SYNTHETIC CONSTRUCT;length:193;seq_nat:MGDNEEVKKMLEKMIEEIKKMLEKAIKKVKEMLEKMIKEIKKMLENGEDSEKILKKAKEMAEKILKMVIELAEKILKKAKEMAEKILKKVKELGVDNEEVKKMLEKMIEEIKKMLEKAIKKVKEMLEKMIKEIKKMLENGEDSEKILKKAKEMAEKILKMVIELAEKILKKAKEMAEKILKKVKELGVGGW;seq_unnat:MGDNEEVKKMLEKMIEEIKKMLEKAIKKVKEMLEKMIKEIKKMLENGEDSEKILKKAKEM... | 22,439.832 | P 1 21 1 | 29.460|72.150|51.260|90.00|92.90|90.00 | X-RAY DIFFRACTION | null | P. Huang;G. Oberdorfer;C. Xu;X.Y. Pei;B.L. Nannenga;J.M. Rogers;F. Dimaio;T. Gonen;B. Luisi;D. Baker | "High Thermodynamic Stability of Parametrically Designed Helical Bundles", Science, 346, 481 | 10.1126/SCIENCE.1257481|25342806|0038|0036-8075|SCIEAS | US | Thermodynamic hyperstability in parametrically designed helical bundles | protein design;de novo protein;thermodynamic hyperstability helical bundle | null | null | null | null | 4uos(0) | null | 7jh6(0.5263000131) | 8w6e(0.5034999847) | 1.10.287.660;6.10.250.2730;1.20.5.1430;1.10.287.70;1.10.287.3290;1.20.5.340;6.10.140.1450;6.10.140.1740;1.10.287.210;1.20.20.10;1.20.5.730;4.10.270.10;6.10.140.1460;6.10.140.740;6.10.250.1010;6.10.280.110;1.20.5.110;6.10.140.1720;1.20.81.20;1.10.287.850;1.10.287.380;1.10.287.3610;1.10.287.1060;1.10.287.160;6.10.140.167... | null |
4uot | 2014-11-05 | other | id:A,B,C,D,E;type:U;source:unknown;length:34;seq_nat:XTQEYLLKEIMKLLKEQIKLLKEQIKMLKELEKQ;seq_unnat:(ACE)TQEYLLKEIMKLLKEQIKLLKEQIKMLKELEKQ | 4,136.095 | C 2 2 21 | 55.400|88.020|103.710|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | P. Huang;G. Oberdorfer;C. Xu;X.Y. Pei;B.L. Nannenga;J.M. Rogers;F. Dimaio;T. Gonen;B. Luisi;D. Baker | "High Thermodynamic Stability of Parametrically Designed Helical Bundles", Science, 346, 481 | 10.1126/SCIENCE.1257481|25342806|0038|0036-8075|SCIEAS | US | Thermodynamic hyperstability in parametrically designed helical bundles | protein design;de novo protein;thermodynamic hyperstability helical bundle | 6g6h(54) | null | 6g6h(1);6dm9(0.975300014) | null | 6g6h(54) | null | 6g6h(1) | null | 6.10.250.770;1.20.5.420;1.20.5.430;1.20.5.1450;1.20.5.700;6.10.250.2150;6.10.250.200;6.10.250.880;6.10.250.2720;6.10.250.270;6.10.250.2060;6.10.250.1090;1.10.287.210;1.20.5.3960;6.10.250.2370;6.10.250.1020;6.10.250.1440;6.10.250.10;1.20.5.1610;6.10.250.850;6.10.250.380;1.20.5.110;1.20.5.250;1.20.5.580;6.10.250.30;1.20.... | null |
4v3o | 2016-01-13 | other | id:A,B,C,D;type:D;source:SYNTHETIC CONSTRUCT;length:292;seq_nat:HHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAV... | 30,548.01 | P 41 | 102.586|102.586|111.107|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | C. Reichen;C. Madhurantakam;S. Hansen;M.G. Grutter;A. Pluckthun;P.R.E. Mittl | "Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects", Acta Crystallogr.,Sect.D, 72, 168 | 10.1107/S2059798315023116|26894544|0766|0907-4449|ABCRE6 | DK | Designed armadillo repeat protein with 5 internal repeats, 2nd generation c-cap and 3rd generation n-cap | rotein engineering;armadillo repeat;de novo protein;repeat protein | 4v3r(527);5mfd(517);5mfe(514);5mfn(514);5aei(514);5mfg(514);5mff(514);5mfh(514);6s9l(492);5mfl(492);6s9o(491);6s9m(490);6s9n(489);6sa7(488);6s9p(479);6sa8(454);4v3q(441);6sa6(427);7r0r(416);4db8(411);7qnp(406);4db9(343);4db6(339);5mfo(327);4dba(317);5mfj(296);5mfi(296);4d49(284);5mfk(284);4d4e(254);5mfb(245);4rv1(212);... | 4plr(540);4plq(524);4pls(521);4bpl(187);4bqk(187);2yns(187);4b8o(187);4b8p(187);4b8j(187);1ee4(186);1ee5(186);1un0(186);2c1t(186);4rxh(186);4xzr(185);4pvz(184);1wa5(184);1bk5(183);1bk6(183);4tnm(181);4uad(180);3tpm(177);3wpt(177);2c1m(177);4u54(177);4u5u(177);4u5v(177);3ve6(177);4u5l(177);4u5n(177);4u5o(177);4u58(177);... | null | null | 4v3r(527) | 4plr(540) | 6s9m(0.9481999874) | 4pls(0.8607000113) | 1.20.930.10;1.25.40.250;1.20.58.1280;1.20.970.10;1.25.40.90;1.25.10.10;1.20.1050.10;1.25.40.60;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.40.970;1.25.40.10;1.20.5.170;1.10.1240.70;1.25.40.170;1.20.1440.250;1.25.40.180;1.25.40.150;1.20.58.690 | null |
4v3q | 2016-01-13 | other | id:A,B,C,D;type:D;source:SYNTHETIC CONSTRUCT;length:250;seq_nat:HHHHHHGSELPQMVQQLNSPDQQELQSALRKLSQIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEKLEQLQSHENEKIQKEAQEALEKLQS;seq_unna... | 26,242.115 | P 32 | 96.498|96.498|96.340|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | C. Reichen;C. Madhurantakam;S. Hansen;M.G. Grutter;A. Pluckthun;P.R. Mittl | "Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects", Acta Crystallogr D Struct Biol, 72, 168-175 | 10.1107/S2059798315023116|26894544||2059-7983| | null | Designed armadillo repeat protein with 4 internal repeats, 2nd generation c-cap and 3rd generation n-cap | protein engineering;de novo protein;armadillo repeat;repeat protein | 4v3o(443);4v3r(437);4db8(424);5mfd(422);5mfe(410);5mfn(410);5aei(410);5mfg(410);5mff(410);5mfh(410);6sa6(409);5mfl(405);6sa7(404);6s9l(401);7r0r(401);6s9m(400);6s9n(399);7qnp(396);6s9o(395);6s9p(389);6sa8(370);4db6(351);4db9(338);4dba(329);5mfo(323);4d49(296);5mfk(296);5mfj(295);5mfi(295);4d4e(267);5mfb(244);4rzp(206);... | 4plr(430);4plq(415);4pls(412);4uad(166);1ee4(165);1ee5(165);4bpl(165);4bqk(165);2yns(165);4b8o(165);4b8p(165);4b8j(165);1un0(164);2c1t(164);4rxh(164);1bk5(163);1bk6(163);4pvz(163);4xzr(163);1wa5(162);4tnm(161);4b18(159);3tj3(159);2jdq(159);3tpm(157);2c1m(157);4u54(157);4u5u(157);4u5v(157);3ve6(157);4u5l(157);4u5n(157);... | null | null | 4v3o(443) | 4plr(430) | 5mfg(0.9194999933) | 4pls(0.9279999733) | 1.25.40.250;1.20.930.10;1.25.40.90;1.25.10.10;1.25.40.550;1.20.1050.10;1.25.40.60;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.25.40.580;1.20.58.1320;1.20.1660.10;1.20.870.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.170;1.25.40.310;1.20.1440.250;1.25.40.1... | null |
4v3r | 2016-01-13 | other | id:A,B;type:D;source:SYNTHETIC CONSTRUCT;length:289;seq_nat:GPGSELPQMVQQLNSPDQQELQSALRKLSQIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGDEQIQAVIDAGALPALVQLLSSPNEQILQEALWTLGNIASGGNEQKQAVKEAGALEK... | 30,032.371 | I 4 | 129.910|129.910|70.200|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | C. Reichen;C. Madhurantakam;S. Hansen;M.G. Grutter;A. Pluckthun;P.R.E. Mittl | "Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects", Acta Crystallogr.,Sect.D, 72, 168 | 10.1107/S2059798315023116|26894544|0766|0907-4449|ABCRE6 | DK | Designed armadillo repeat protein with 5 internal repeats, 2nd generation c-cap and 3rd generation n-cap | protein engineering;de novo protein;repeat protein | 4v3o(528);5mfd(516);5mfe(512);5mfn(512);5aei(512);5mfg(512);5mff(512);5mfh(512);6s9l(491);6s9o(490);6s9m(489);6s9n(488);5mfl(488);6sa7(479);6s9p(478);6sa8(444);4v3q(436);6sa6(424);7r0r(411);7qnp(400);4db8(392);4db6(329);5mfo(324);4db9(321);4dba(308);5mfj(291);5mfi(291);4d49(282);5mfk(282);5mfb(240);4d4e(233);4rv1(220);... | 4plq(519);4plr(516);4pls(511);1un0(188);2c1t(188);1ee4(187);1ee5(187);4bpl(187);4bqk(187);2yns(187);4b8o(187);4b8p(187);4rxh(187);4b8j(187);4pvz(186);4xzr(186);1wa5(185);1bk5(184);1bk6(184);4tnm(181);4uad(177);4uae(174);3tpm(174);3wpt(174);2c1m(174);4u54(174);4u5u(174);4u5v(174);3ve6(174);4u5l(174);4u5n(174);4u5o(174);... | 5mfh(0.9595999718);5mfe(0.9517999887);5mff(0.9549999833);6s9l(0.9570000172);6s9n(0.9577000141);6s9m(0.9593999982);6sa7(0.950600028);6sa8(0.9519000053) | null | 4v3o(528) | 4plq(519) | 5mfh(0.9595999718) | 4pls(0.8654999733) | 1.25.40.300;1.25.40.250;1.20.930.10;1.20.190.60;1.25.40.90;1.25.10.10;1.25.40.420;1.25.40.550;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.25.40.580;1.20.1660.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.810;1.10.3480.20;1.25.40.170;1.25.40.720;1.20.1440.2... | null |
4wn4 | 2014-12-24 | other | id:A,B;type:D;source:synthetic construct;length:306;seq_nat:GNSVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGKAGRLEEALELFEEMKEKGIVPNVVTYTTLISGLGK... | 33,225.145 | F 2 3 | 204.720|204.720|204.720|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Coquille;A. Filipovska;T. Chia;L. Rajappa;J.P. Lingford;M.F. Razif;S. Thore;O. Rackham | "An artificial PPR scaffold for programmable RNA recognition", Nat Commun, 5, 5729-5729 | 10.1038/ncomms6729|25517350||2041-1723| | UK | Crystal structure of designed cppr-polya protein | rna-protein interactions;designer rna-binding proteins;synthetic biology;de novo protein;pentatricopeptide repeat | 4wsl(561);5orm(557) | 9epc(231);4m59(229);4m57(229);4oe1(228);9gyt(183);9kfx(180);9kfy(180);9evs(179);4leu(60);8rri(59) | null | null | 4wsl(561) | 9epc(231) | 5orm(0.9233000278) | 4m57(0.7799000144) | 1.25.40.290;1.25.40.250;1.25.40.440;1.25.40.40;1.25.40.70;1.10.10.2400;1.10.220.10;1.20.930.10;1.10.10.750;1.25.40.580;1.25.10.10;1.25.40.420;1.25.40.10;1.25.40.970;1.10.3450.10;1.25.40.320;1.25.40.60;1.25.40.850 | null |
4wsl | 2014-12-24 | other | id:A;type:D;source:Synthetic construct;length:306;seq_nat:GNSVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAGRLEEALELFEEMKEKGIVPSVVTYNTLISGLGKAG... | 32,750.781 | P 43 2 2 | 119.300|119.300|55.750|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Coquille;A. Filipovska;T. Chia;L. Rajappa;J.P. Lingford;M.F. Razif;S. Thore;O. Rackham | "An artificial PPR scaffold for programmable RNA recognition", Nat Commun, 5, 5729-5729 | 10.1038/ncomms6729|25517350||2041-1723| | UK | Crystal structure of designed cppr-polyc protein | rna-protein interactions;designer rna-binding proteins;synthetic biology;de novo protein;pentatricopeptide repeat | 4wn4(561);5orm(546) | 4m59(240);4m57(240);4oe1(239);9epc(235);9gyt(185);9kfx(184);9kfy(184);9evs(182);8rri(60);4leu(58) | null | null | 4wn4(561) | 4m59(240) | 5orm(0.875) | 4m57(0.725300014) | 1.20.930.10;1.20.5.420;1.25.10.10;1.25.40.420;1.25.40.60;1.25.40.40;1.25.40.70;1.20.1280.150;1.20.58.2200;1.10.3450.10;1.20.50.50;1.25.40.1040;1.25.40.850;1.25.40.290;1.25.40.440;1.10.10.2400;6.10.250.1250;1.20.58.80;1.25.40.970;1.25.40.10;1.10.10.1270;1.20.58.2070;1.10.220.10;6.10.140.270;1.20.50.30;1.20.58.290 | null |
4yc5 | 2016-03-09 | other | id:A;type:D;source:synthetic construct;length:237;seq_nat:MGSSHHHHHHSSGLVPRGSHMNVGEILRHYAAGKRNFQHINLQEIELTNASLTGADLSYANLHHANLSRANLRSADLRNANLSHANLSGANLEEANLEAANLRGADLHEANLSGADLQEANLTQANLKDANLSDANLEQADLAGADLQGAVLDGANLHGANLNNANLSEAMLTRANLEQADLSGARTTGARLDDADLRGATVDPVLWRTASLVGARVDVDQAVAFAAAHGLCLAG;seq_unnat:MGSSHHHHHHSSGLVP... | 24,676.037 | P 41 2 2 | 64.570|64.570|160.400|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | J.T. MacDonald;B.V. Kabasakal;D. Godding;S. Kraatz;L. Henderson;J. Barber;P.S. Freemont;J.W. Murray | "Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension", Proc.Natl.Acad.Sci.USA, 113, 10346-10351 | 10.1073/pnas.1525308113|27573845|0040|1091-6490|PNASA6 | US | Beta1 synthetic solenoid protein | solenoid;scaffold;structural protein | 5dzb(437);4yfo(437);5dn0(417);5di5(416);5dqa(416);5dns(415);5dra(400);7m0q(53);6vgb(50);6y07(50) | 4ydt(451);4ycq(451);4yei(446);3du1(212);2j8k(175);2bm4(142);2bm5(142);2bm6(142);2bm7(142);2j8i(115);2f3l(78);2g0y(78);2hwv(59);3ixr(58);4evd(57);4eve(57);3ta8(57);3t9j(57);4evb(57);4evc(57);2b4o(57);2b4p(57);2b4u(57);21jh(57);21kg(57);4l3f(56);2vq9(55);4owy(55);2wc9(55);2wbn(55);3vol(55);2dps(55);2dpt(55);3nd1(55);4d2w... | 5dqa(0.9840999842);5dns(0.9628999829) | 4yei(0.9983999729) | 5dzb(437) | 4ydt(451) | 5dqa(0.9840999842) | 4yei(0.9983999729) | 6.10.250.1960;6.10.250.1110;1.20.5.510;6.10.250.2050;4.10.180.60;6.10.250.400;1.20.5.460;4.10.180.10;6.10.250.1590;2.160.20.50;6.10.250.1560;1.20.5.220;1.20.5.640;6.10.250.1990;2.160.20.80 | null |
4ydw | 2015-03-04 | other | id:A,B;type:D;source:synthetic construct;length:171;seq_nat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNALDDSGYTPLHLAAEDGHLEIVEVLLKHGADVNAADRLGDTPLHLAAFVGHLEIVEVLLKAGADVNAVDLAGVTPLHVAAFYGHLEIVEVLLKAGADVNAQDKFGKTPADIAADNGHEDIAEVLQKLN;seq_unnat:MRGSHHHHHHGSDLGKKLLEAARAGQDDEVRILMANGADVNALDDSGYTPLHLAAEDGHLEIVEVLLKHGADVNAADRLG... | 17,887.037 | P 21 21 21 | 60.240|60.740|81.890|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | A. Teplyakov;G. Obmolova;G. Gilliland | To be published | |||| | null | Crystal structure of anti-il4 darpin 44c12v5 | de novo protein;alternative scaffold | 5kng(296);5knh(296);8ql6(284);8ql5(284);8ql9(284);9u6a(284);8ql2(284);8ql3(284);9f8g(284);8qlb(284);8qla(284);8ql7(284);8ql8(284);8qea(284);8ql4(284);4dui(284);5op3(279);4j7w(278);4j8y(278);6fp9(278);8u1b(276);9dmi(276);5oou(273);9fe2(273);9fe3(273);5lw2(273);5oos(270);7dng(270);7dnf(270);9f07(270);5le9(266);5le8(266);... | 4ydy(340);4f6r(288);4hna(288);4lnu(284);4drx(284);4k5b(278);4hrm(278);2y1l(277);2p2c(276);1svx(276);3noc(275);4dx6(273);4u96(273);4dx7(273);4u8v(273);9fhc(273);3zu7(273);4u8y(273);2j8s(273);9fhg(273);9fhj(273);9hao(273);4c48(273);9hci(273);4dx5(273);4u95(273);3nog(272);4hrl(271);2bkk(270);2v5q(269);9kcq(269);9kbu(269);... | 5knh(0.9745000005);9gtk(0.9812999964);4j8y(0.9842000008);5kng(0.976000011);2xeh(0.9747999907);2xee(0.9792000055);7z7e(0.983099997);6fpb(0.9735999703);7b4t(0.9689000249);9epa(0.9769999981);1mj0(0.976000011);6fpa(0.9581999779);6fp9(0.9689000249);9gnb(0.9541000128);7z72(0.9617000222);9g8i(0.959100008);5le7(0.9684000015);5... | 4ydy(0.9761999846);4k5b(0.97299999);4hna(0.9720000029);4k5a(0.9754999876);4k5c(0.9635000229);4jb8(0.9648000002);4hrl(0.9584000111);4hll(0.9546999931) | 5kng(296) | 4ydy(340) | 4j8y(0.9842000008) | 4ydy(0.9761999846) | 1.10.10.2400;1.25.40.40;1.10.220.10 | null |
4yfo | 2016-03-16 | other | id:A;type:D;source:synthetic construct;length:262;seq_nat:MGSSHHHHHHSSGLVPRGSHMNVGEILRHYAAGKRNFQHINLQEIELTNASLTGADLSYANLHHANLSRANLRSADLRNANLSHANLSGANLEEANLEAANLRGADLHEANLSGADLQEANLTQANLKDANLSDANLEQADLAGADLQGAVLDGANLHGADLNGADLKQADLSGADLGGANLNNANLSEAMLTRANLEQADLSGARTTGARLDDADLRGATVDPVLWRTASLVGARVDVDQAVAFAAAHGLCLAGGSGC;se... | 26,864.357 | H 3 2 | 105.180|105.180|323.500|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | J.T. MacDonald;B.V. Kabasakal;D. Godding;S. Kraatz;L. Henderson;J. Barber;P.S. Freemont;J.W. Murray | "Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension", Proc.Natl.Acad.Sci.USA, 113, 10346-10351 | 10.1073/pnas.1525308113|27573845|0040|1091-6490|PNASA6 | US | Beta1_ex1 | solenoid;de novo protein;synthetic protein | 5dzb(494);4yc5(439);5dn0(414);5dqa(413);5dns(412);5di5(410);5dra(396);7m0q(53);6vgb(50);6y07(50) | 4ydt(439);4ycq(439);4yei(434);3du1(233);2j8k(171);2bm4(145);2bm5(145);2bm6(145);2bm7(145);2j8i(115);2f3l(79);2g0y(79);2hwv(59);3ixr(58);4evd(57);4eve(57);3ta8(57);3t9j(57);4evb(57);4evc(57);2b4o(57);2b4p(57);2b4u(57);3s6g(57);3s6h(57);4kzt(57);3s7y(57);21jh(57);21kg(57);4l3f(56);2vq9(55);4yr8(55);4owy(55);2wc9(55);2wbn... | 5dzb(0.9860000014) | null | 5dzb(494) | 4ydt(439) | 5dzb(0.9860000014) | 4yei(0.8702999949) | 6.10.250.2050;2.160.20.50 | null |
4yxx | 2015-12-16 | other | id:A;type:U;source:unknown;length:222;seq_nat:VSLEQALKILKVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKLGTTVEEAVKRALKLKTKLGVSLEQALKILKVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKLGTTVEEAVKRALKLKTKLGGWLEHHHHHH;seq_unnat:VSLEQALKILKVAAELGTTVEEAVKRALKLKTKLGVSLEQALK... | 23,763.473 | C 2 2 21 | 63.460|85.048|80.464|90.000|90.000|90.000 | X-RAY DIFFRACTION | Rosetta designed | L. Doyle;J. Hallinan;J. Bolduc;F. Parmeggiani;D. Baker;B.L. Stoddard;P. Bradley | "Rational design of alpha-helical tandem repeat proteins with closed architectures", Nature, 528, 585-588 | 10.1038/nature16191|26675735|0006|1476-4687|NATUAS | UK | Computationally designed left-handed alpha/alpha toroid with 6 repeats | toroid;alpha helix;left-handed;computationally designed;rosetta;de novo protein | 9gvf(307);8s6p(307);9h3c(295);8c3w(280);4yxz(171);5byo(171);4yxy(91) | null | null | null | 9gvf(307) | null | 9gvf(0.9437000155) | 4fp9(0.47299999) | 1.10.8.1000;1.10.8.60;1.10.8.870 | null |
4yxy | 2015-12-16 | other | id:A,B,C,D;type:U;source:unknown;length:118;seq_nat:MASSHHHHHHSSGLVPRGSSMASGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLG;seq_unnat:MASSHHHHHHSSGLVPRGSSMASGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLG | 12,575.428 | P 43 21 2 | 102.787|102.787|93.930|90.000|90.000|90.000 | X-RAY DIFFRACTION | Rosetta designed | L. Doyle;J. Hallinan;J. Bolduc;F. Parmeggiani;D. Baker;B.L. Stoddard;P. Bradley | "Rational design of alpha-helical tandem repeat proteins with closed architectures", Nature, 528, 585-588 | 10.1038/nature16191|26675735|0006|1476-4687|NATUAS | UK | Computationally designed left-handed alpha/alpha toroid with 9 repeats; two linked rings of 12 repeats each structure | toroid;alpha helix;left-handed;computationally designed;rosetta;de novo protein | 4yxz(186);5byo(186);9h3c(81);9gvf(74);8s6p(74);8c3w(70);8etq(50) | 4hnt(56);4hnu(56);3bg5(56);4hnv(55);3w2z(52);3qwy(52);4pu4(51);4pu7(51);4pu8(51);4pu3(51);2y78(51);2o4e(51);9heh(51);3aov(51);3aow(51);3ath(51);3av7(51);3wx9(51);5apo(51);5apn(51);1wwr(50);3pac(50);9g5j(50);9g3t(50);9g0j(50);3h7r(50) | 5byo(0.9794999957) | null | 4yxz(186) | 4hnt(56) | 5byo(0.9794999957) | 2zc2(0.524699986) | 6.10.250.140;1.20.5.420;1.10.10.630;1.20.120.1920;1.10.8.60;1.10.8.1000;1.10.8.10;1.10.1220.10 | null |
4yxz | 2015-12-16 | other | id:A;type:U;source:unknown;length:289;seq_nat:GSSMASGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTT... | 30,825.73 | P 21 21 21 | 41.736|72.019|86.186|90.000|90.000|90.000 | X-RAY DIFFRACTION | Rosetta designed | L. Doyle;J. Hallinan;J. Bolduc;F. Parmeggiani;D. Baker;B.L. Stoddard;P. Bradley | "Rational design of alpha-helical tandem repeat proteins with closed architectures", Nature, 528, 585-588 | 10.1038/nature16191|26675735|0006|1476-4687|NATUAS | UK | Computationally designed left-handed alpha/alpha toroid with 9 repeats | toroid;alpha helix;left-handed;computationally designed;rosetta;de novo protein | 5byo(530);4yxy(187);9gvf(130);8s6p(130);9h3c(124);8c3w(108) | null | null | null | 5byo(530) | null | 5byo(0.880400002) | 4ot0(0.4550999999) | 1.10.8.10 | null |
4yy2 | 2015-12-16 | other | id:A,B,C,D;type:U;source:unknown;length:104;seq_nat:GSSMGKSPTEVLLELIAEASGTTREEVKEKFLKELRKGKSPTEVLLELIAEASGTTKEEVKEKFLKELSFGKSPTEVLLELIAEASGTTKEEVKKKFWKELSL;seq_unnat:GSSMGKSPTEVLLELIAEASGTTREEVKEKFLKELRKGKSPTEVLLELIAEASGTTKEEVKEKFLKELSFGKSPTEVLLELIAEASGTTKEEVKKKFWKELSL | 11,417.165 | P 21 21 21 | 37.139|68.603|152.357|90.000|90.000|90.000 | X-RAY DIFFRACTION | Rosetta designed | L. Doyle;J. Hallinan;J. Bolduc;F. Parmeggiani;D. Baker;B.L. Stoddard;P. Bradley | "Rational design of alpha-helical tandem repeat proteins with closed architectures", Nature, 528, 585-588 | 10.1038/nature16191|26675735|0006|1476-4687|NATUAS | UK | Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group p212121 | toroid;alpha helix;left-handed;computationally designed;rosetta;de novo protein | 4yy5(181) | null | 4yy5(0.9692000151) | null | 4yy5(181) | null | 4yy5(0.9692000151) | 2gzx(0.5123999715) | 1.10.1200.160;1.10.287.540;1.20.5.710;1.20.5.420;1.10.40.30;1.10.246.80;1.10.8.10;6.10.130.40;6.10.10.20;6.10.250.3140;1.10.1220.10 | null |
4yy5 | 2015-12-16 | other | id:A,B;type:U;source:unknown;length:100;seq_nat:GKSPTEVLLELIAEASGTTREEVKEKFLKELRKGKSPTEVLLELIAEASGTTKEEVKEKFLKELSFGKSPTEVLLELIAEASGTTKEEVKKKFWKELSL;seq_unnat:GKSPTEVLLELIAEASGTTREEVKEKFLKELRKGKSPTEVLLELIAEASGTTKEEVKEKFLKELSFGKSPTEVLLELIAEASGTTKEEVKKKFWKELSL | 11,054.763 | P 43 21 2 | 40.184|40.184|217.676|90.000|90.000|90.000 | X-RAY DIFFRACTION | Rosetta designed | L. Doyle;J. Hallinan;J. Bolduc;F. Parmeggiani;D. Baker;B.L. Stoddard;P. Bradley | "Rational design of alpha-helical tandem repeat proteins with closed architectures", Nature, 528, 585-588 | 10.1038/nature16191|26675735|0006|1476-4687|NATUAS | UK | Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group p43212 | toroid;alpha helix;left-handed;computationally designed;rosetta;de novo protein | 4yy2(181) | null | 4yy2(0.9800999761) | null | 4yy2(181) | null | 4yy2(0.9800999761) | 3f52(0.5340999961) | 1.10.1200.160;1.20.5.870;1.20.5.710;1.20.5.420;1.10.40.30;1.10.246.80;1.10.8.10;6.10.130.40;6.10.10.20;6.10.250.3140;1.10.1220.10 | null |
4z08 | 2016-04-13 | other | id:A;type:U;source:unknown;length:267;seq_nat:MALAKRIIAALIVKDGRVVKGSNFENLRDSGDPVELGKFYSEIGIDELSFWDITASVEKRKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVEINTAAVENPSLITQIAQTFGSQAVVVYIAAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEIVLGSIDRLGTKSGYDTEMIRFVRPLTTLPIIAHGGAGKMEHFLEAFLAGADAAKANSVLHFREIDVRELKEYLKKHGVNVRLEGLGSLEHHHHHH;seq_unnat... | 29,159.408 | P 61 2 2 | 97.220|97.220|156.278|90.00|90.00|120.00 | X-RAY DIFFRACTION | null | N.-S. Hong;C.J. Jackson;P.D. Carr | To be published | |||| | null | Directed evolutionary changes in kemp eliminase ke07 - crystal 1 ke07 design | de novo protein, lyase;lyase;ke07;de novo protein;kemp eliminase;directed evolution | 5d2w(527);5d2v(527);5d2t(527);5d2y(516);5d30(516);5d2x(516);5d32(509);5d38(507);5d33(500);5d37(500);3tdn(246);3tdm(184) | 3iio(508);2rkx(504);3iiv(501);3iip(496);1vh7(471);1gpw(462);1thf(462);4ewn(462);3zr4(461);2wjz(461);2a0n(461);8s8r(459);8s8s(453);4evz(299);3cwo(287);2lle(274);2w6r(259);4fx7(255);3og3(253);1ka9(249);4j9j(244);1h5y(226);1ox4(144);1ox5(144);1jvn(144);1ox6(144);4axk(85);5a5w(73);5ahf(72);5ahi(72);4gj1(71);4u28(68);4tx9(6... | 5d2w(0.9947999716);5d2t(0.983799994);5d2v(0.991599977);5d2y(0.9843999743);5d30(0.9882000089);5d2x(0.9793999791);5d32(0.9767000079);5d38(0.9628999829);5d33(0.9739999771);5d37(0.9660000205) | 2rkx(0.9909999967);2a0n(0.9908000231);3iio(0.980799973);3iip(0.9731000066) | 5d2w(527) | 3iio(508) | 5d2w(0.9947999716) | 2rkx(0.9909999967) | 3.40.1260.10;3.40.50.12600 | null |
4z1r | 2015-11-18 | other | id:A,B,C;type:U;source:unknown;length:30;seq_nat:PPGPPGPPGPPGPPAPPGPPGPPGPPGPPG;seq_unnat:P(HYP)GP(HYP)GP(HYP)GP(HYP)GP(HYP)AP(HYP)GP(HYP)GP(HYP)GP(HYP)GP(HYP)G | 2,704.854 | C 1 2 1 | 171.573|13.939|24.981|90.000|94.590|90.000 | X-RAY DIFFRACTION | null | M.E. Plonska-Brzezinska;D.M. Bobrowska;A. Sharma;P. Rodziewicz;M. Tomczyk;J. Czyrko;K. Brzezinski | "Triple helical collagen-like peptide interactions with selected polyphenolic compounds", Rsc Adv, 5, 95443-95453 | 10.1039/c5ra15469c|||2046-2069| | UK | Crystal structure of collagen-like peptide at 1.27 angstrom resolution | collagen;structural protein;triple helix | null | null | null | null | 4z1r(0) | null | null | null | null | null |
4zcn | 2015-07-01 | other | id:A,B,C;type:U;source:unknown;length:88;seq_nat:GSHMFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVL;seq_unnat:GSHMFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVL | 8,763.629 | P 1 21 1 | 31.582|70.368|43.738|90.00|107.14|90.00 | X-RAY DIFFRACTION | null | A.R.D. Voet;H. Noguchi;C. Addy;K.Y.J. Zhang;J.R.H. Tame | To be published | |||| | null | Crystal structure of nvpizza2-s16s58 | computational protein design;permutation;beta-propeller;self-assembling;de novo protein | 5f53(174);5i1z(173);5i1y(173);5chb(172);6i37(169);6reh(166);6qsf(166);6rei(166);7ov7(166);6qsg(166);6qsh(166);6reg(166);6qsd(166);6qse(166);6f0t(165);6rej(164);6rek(164);6rem(164);6f0s(164);6rel(164);7zq2(163);7zqg(163);7zcj(163);6i38(161);6f0q(161);7zpz(161);6i3b(160);6i39(160);6i3a(160);7zpw(160);7zph(158);6reo(156);... | 1rwi(123);1rwl(123) | 5f53(0.9689999819);5i1z(0.9671000242);5i1y(0.9648000002);5chb(0.9577999711);3ww8(0.9524000287);6f0t(0.9527999759);7ov7(0.9563000202);6reg(0.9700000286);6i39(0.9593999982);7zpw(0.959100008);6qsg(0.9661999941);6rei(0.9634000063);7zqg(0.9639999866);6qse(0.9672999978);6reh(0.9616000056);6reo(0.9505000114);6ren(0.950699985)... | null | 5f53(174) | 1rwi(123) | 6reg(0.9700000286) | 1rwi(0.9247999787) | 2.40.10.500;2.20.25.650;2.40.128.190;2.40.10.360 | null |
4zv6 | 2016-05-25 | other | id:A;type:D;source:synthetic construct;length:297;seq_nat:MRGSHHHHHHTDPEKVEMYIKNLQDDSTTVRFNAAYALGKIGDERAVEPLIKALKDEDWLVRFSAARALGEIGDERAVEPLIKALKDEDSSVRFSAAYALGKIGDERAVEPLIKALKDEDPRVRRIAAGALGEIGDERAVEPLIKALKDEDPYVRMAAAYALGKIGDERAVEPLIKALKDEDGYVRRAAAYALGKIGDERAVEPLIKALKDEDENVRLAAAQALGKIGDERAVEPLIKALKDEDRYVRLTAARALGKIGGER... | 32,362.977 | P 1 21 1 | 73.133|42.021|85.186|90.00|106.35|90.00 | X-RAY DIFFRACTION | null | M. Figueroa;M. Sleutel;M. Vandevenne;G. Parvizi;S. Attout;O. Jacquin;J. Vandenameele;A.W. Fischer;C. Damblon;E. Goormaghtigh;M. Valerio-Lepiniec;A. Urvoas;D. Durand;E. Pardon;J. Steyaert;P. Minard;D. Maes;J. Meiler;A. Matagne;J.A. Martial;C. Van de Weerdt | "The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools", J.Struct.Biol., 195, 19-30 | 10.1016/j.jsb.2016.05.004|27181418|0803|1095-8657|JSBIEM | US | Crystal structure of the artificial alpharep-7 octarellinv.1 complex | rossmann-like;de novo protein;synthetic gene;artificial protein | 6bzx(572);3ltj(294);4jw2(294);3ltm(281);6veh(245);4jw3(194) | 5bop(425);4xl5(408);4xvp(243);1te4(138);4d4z(77);4d50(77) | 6bzx(0.9610999823) | null | 6bzx(572) | 5bop(425) | 6bzx(0.9610999823) | 4xvp(0.8960000277) | 1.25.40.250;1.20.930.10;1.25.40.90;1.25.10.10;1.25.40.750;1.25.40.40;1.25.40.70;3.40.50.720;3.40.50.620;3.40.50.2000;1.25.40.850;1.25.40.290;3.40.50.80;1.25.40.450;1.25.60.10;1.25.40.10;3.40.50.11700;1.10.1240.70;1.25.40.320;3.40.50.20;1.25.40.180;1.25.40.20 | null |
5a0o | 2015-07-15 | other | id:B,S;type:D;source:SYNTHETIC CONSTRUCT;length:108;seq_nat:MASNSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQANLYLSTPIDTMYYLTLEAKDGGKKKLYEAKVWVKHIMYYPKTANFKELQEFKPVGDAAAAHHHHHHHH;seq_unnat:MASNSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQANLYLSTPIDTMYYLTLEAKDGGKKKLYEAKVWVKHIMYYPKTANFKELQEFKPVGDAAAAHHHHHHHH | 12,465.246 | I 21 21 21 | 69.290|72.640|107.930|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | H.F. Kyle;K.F. Wickson;J. Stott;G.M. Burslem;A.L. Breeze;C. Tiede;D.C. Tomlinson;S.L. Warriner;A. Nelson;A.J. Wilson;T.A. Edwards | "Exploration of the Hif-1Alpha.P300 Interface Using Peptide and Adhiron Phage Display Technologies", Mol.Biosyst., 11, 2738 | 10.1039/C5MB00284B|26135796||1742-206X| | UK | Adhiron raised against p300 | de novo protein;affimer | 7zqa(145);7zq8(145);4n6u(125);4n6t(125) | 9guc(158);3ima(95);2l4v(93);1eqk(92);3ul6(88);3ul5(88);4lzi(87);2w9p(71);2w9q(71) | null | null | 7zqa(145) | 9guc(158) | 4n6t(0.8399000168) | 3ima(0.7857999802) | 2.60.40.2760;3.30.310.80;6.10.140.2050;6.20.50.130;6.10.20.80;3.10.450.40;3.10.450.100;3.10.450.10;3.30.200.70;1.10.287.580;3.10.450.540;3.30.1300.40;3.30.200.20;3.10.450.380;3.10.450.50 | null |
5aei | 2016-03-30 | other | id:A,B,C;type:D;source:SYNTHETIC CONSTRUCT;length:289;seq_nat:GPGSELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKEAGAL... | 30,027.445 | C 2 2 21 | 88.830|215.280|105.990|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Hansen;D. Tremmel;C. Madhurantakam;C. Reichen;P.R.E. Mittl;A. Pluckthun | "Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity", J.Am.Chem.Soc., 138, 3526 | 10.1021/JACS.6B00099|26878586|0004|0002-7863|JACSAT | US | Designed armadillo repeat protein yiiim5aii in complex with peptide (kr)5 | alpha-helical protein;solenoid protein;protein-peptide complex;repeat protein;de novo protein | 5mfe(538);5mfn(538);5mfg(538);5mff(538);5mfh(538);6s9l(517);4v3o(516);6s9o(515);4v3r(514);5mfl(514);6s9m(512);6s9n(512);5mfd(504);6sa7(504);6s9p(502);6sa8(470);7r0r(434);7qnp(422);4db8(413);4v3q(411);6sa6(411);4db6(346);5mfo(344);4db9(340);4dba(325);5mfj(309);5mfi(309);4d49(297);5mfk(297);5mfb(259);4d4e(249);4rv1(223);... | 4plq(507);4plr(504);4pls(499);1ee4(191);1ee5(191);1un0(191);2c1t(191);4pvz(190);4xzr(190);1wa5(189);1bk5(188);1bk6(188);4uad(186);4rxh(186);4bpl(185);4bqk(185);2yns(185);4b8o(185);4b8p(185);4b8j(185);4uae(181);3wpt(179);4b18(179);3tj3(179);2jdq(179);3tpm(178);2c1m(178);4u54(178);4u5u(178);4u5v(178);3ve6(178);4u5l(178);... | 5mfh(0.9581000209);5mfe(0.9599000216);5mff(0.9696999788);6s9n(0.9771000147);6s9m(0.9768999815);6s9l(0.9559000134);5mfn(0.950699985) | null | 5mfe(538) | 4plq(507) | 6s9n(0.9771000147) | 4pls(0.8646000028) | 1.25.40.300;1.25.40.250;1.20.930.10;1.20.58.1280;1.20.190.60;1.25.40.90;1.25.10.10;1.25.40.550;1.25.40.240;1.25.40.750;1.25.40.40;1.25.40.70;1.20.58.690;1.25.40.580;1.20.1660.10;1.25.40.850;1.25.40.290;1.25.40.450;1.25.60.10;1.25.40.970;1.25.40.10;1.10.1240.70;1.25.40.320;1.25.40.810;1.25.40.170;1.25.40.310;1.20.1440.2... | null |
5awl | 2015-08-12 | other | id:A;type:U;source:unknown;length:10;seq_nat:YYDPETGTWY;seq_unnat:YYDPETGTWY | 1,294.322 | P 21 21 2 | 19.246|33.597|11.551|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | S. Honda;T. Akiba;Y.S. Kato;Y. Sawada;M. Sekijima;M. Ishimura;A. Ooishi;H. Watanabe;T. Odahara;K. Harata | "Crystal structure of a ten-amino acid protein", J.Am.Chem.Soc., 130, 15327-15331 | 10.1021/ja8030533|18950166||1520-5126|JACSAT | US | Crystal structure of a mutant of chignolin, cln025 | miniature protein;de novo protein;mini-protein;beta-hairpin | null | null | null | null | 5awl(0) | null | 2evq(0.8999999762) | null | null | null |
5bvb | 2015-10-28 | other | id:A,B,C,D;type:U;source:unknown;length:133;seq_nat:GSSMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRILEAAG;seq_unnat:GSSMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPL... | 15,073.011 | P 1 21 1 | 60.732|68.623|72.084|90.000|113.560|90.000 | X-RAY DIFFRACTION | null | R.D. Smith;K.L. Damm-Ganamet;J.B. Dunbar;A. Ahmed;K. Chinnaswamy;J.E. Delproposto;G.M. Kubish;C.E. Tinberg;S.D. Khare;J. Dou;L. Doyle;J.A. Stuckey;D. Baker;H.A. Carlson | "CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge", J.Chem.Inf.Model., 56, 1022-1031 | 10.1021/acs.jcim.5b00387|26419257||1549-960X| | US | Engineered digoxigenin binder dig5.1a | ligand binder;computationally designed;digoxigenin;designed;de novo protein;engineered | null | 1z1s(254);4j8t(246);4j9a(237);1s5a(89);3juo(50);3jup(50);3juq(50);3dzl(50);3ex9(50);3cnm(50);3b4o(50);3b4p(50);3jum(50);3jun(50) | null | null | 5bvb(0) | 1z1s(254) | 5ier(0.675999999) | 4j8t(0.9412999749) | 3.10.450.540;3.10.450.280;3.10.450.100;3.10.450.10;3.10.450.230;3.10.450.50 | null |
5bvl | 2015-11-18 | other | id:A;type:D;source:synthetic construct;length:196;seq_nat:MDKDEAWKCVEQLRREGATQIAYRSDDWRDLKEAWKKGADILIVDATDKDEAWKQVEQLRREGATQIAYRSDDWRDLKEAWKKGADILIVDATDKDEAWKQVEQLRREGATQIAYRSDDWRDLKEAWKKGADILIVDATDKDEAWKQVEQLRREGATQIAYRSDDWRDLKEAWKKGADILICDATGLEHHHHHH;seq_unnat:MDKDEAWKCVEQLRREGATQIAYRSDDWRDLKEAWKKGADILIVDATDKDEAWKQVE... | 22,896.449 | P 41 21 2 | 50.080|50.080|131.280|90.00|90.00|90.00 | X-RAY DIFFRACTION | null | P.S. Huang;K. Feldmeier;F. Parmeggiani;D.A. Fernandez Velasco;B. Hocker;D. Baker | "De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy", Nat.Chem.Biol., 12, 29-34 | 10.1038/nchembio.1966|26595462||1552-4469| | US | Crystal structure of a de novo designed tim-barrel | tim-barrel;idealized scaffold;de novo protein;computational design | 6yqy(403);7ot7(397);7osu(397);7a8s(387);6z2i(338);7ot8(335);7osv(335);6yqx(276);7p12(263);6wvs(233);7mcc(134);7smj(128);7mcd(119);6wxo(99);9qul(98);9quo(98);9qud(98);9qui(98);9quc(98);6zv9(98);6wxp(98) | null | null | null | 6yqy(403) | null | 6yqy(0.9075999856) | 1h5y(0.6060000062) | 3.20.20.10;3.20.20.60;3.20.20.390;3.20.20.380;3.20.20.120;3.20.20.150;3.20.20.80;3.20.20.70;3.20.20.140 | null |
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