design_id
string
rank
int64
batch
string
central_heterocycle
string
smiles
string
isomeric_smiles_pose
string
vina_score
float64
ligand_efficiency
float64
buried_sasa_pct
float64
sa_score
float64
mw
float64
clogp
float64
tpsa
float64
qed
float64
hbd
int64
hba
int64
rotatable_bonds
int64
heavy_atoms
int64
aromatic_rings
int64
fsp3
float64
formal_charge
int64
murcko_scaffold
string
n_contact_residues
int64
contact_residues
string
total_interactions
int64
hbonds
int64
hydrophobic
int64
pi_stacking
int64
cation_pi
int64
halogen_bonds
int64
anchor_phe203_hbond
int64
anchor_tyr249_pistack
int64
anchor_arg95_cationpi
int64
sam_centroid_dist_ang
float64
sam_adenine_occupancy
float64
sam_ribose_occupancy
float64
sam_methionine_arm_occupancy
float64
hlm_clint_ml_min_g
float64
hepatocyte_clint
float64
logd_7_4
float64
logs_aqueous
float64
half_life_h
float64
ppb_pct
float64
caco2_logpapp
float64
herg_prob
float64
cyp3a4_inhib_prob
float64
cyp2d6_inhib_prob
float64
dili_prob
float64
ames_prob
float64
bbb_prob
float64
pose_file
string
63_SAMT_II2608242113216051107112a
101
1
7-azaindole
CC(C)c1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)nc(N)n1
CC(C)c1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)nc(N)n1
-13.7
0.4152
77.1
3.7615
440.507
4.2928
118.81
0.4355
3
6
4
33
4
0.28
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccncn5)cc34)ccc21
9
ARG95;ILE96;PHE175;PRO177;ILE191;ASP202;PHE203;LEU246;TYR249
10
3
6
0
1
0
1
0
1
0.82
1
1
1
29.5983
18.4082
3.2367
-5.59
60.1127
99.5974
-5.1242
0.8307
0.6754
0.0689
0.9647
0.5723
0.4047
structures/63_SAMT_II2608242113216051107112a_complex.pdb
63_SAMT_II260824211321605111125a
102
1
7-azaindole
Nc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2nn[nH]c2n1
Nc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2nn[nH]c2n1
-13.7
0.4152
74.2
4.0689
439.439
2.4407
160.38
0.3333
4
8
3
33
5
0.1818
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6[nH]nnc56)cc34)ccc21
6
ARG95;SER173;ILE191;PHE203;LEU246;TYR249
8
4
3
0
1
0
1
0
1
1
1
1
1
5.1369
2.8275
1.4298
-5.4574
65.3987
95.2408
-5.6294
0.4969
0.2587
0.0186
0.9963
0.7908
0.4278
structures/63_SAMT_II260824211321605111125a_complex.pdb
63_SAMT_II260824211321605111125b
103
1
7-azaindole
Nc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2nn[nH]c2n1
Nc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2nn[nH]c2n1
-13.7
0.4152
74
4.0689
439.439
2.4407
160.38
0.3333
4
8
3
33
5
0.1818
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6[nH]nnc56)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
7
3
3
0
1
0
1
0
1
1.22
1
1
1
5.1369
2.8275
1.4298
-5.4574
65.3987
95.2408
-5.6294
0.4969
0.2587
0.0186
0.9963
0.7908
0.4278
structures/63_SAMT_II260824211321605111125b_complex.pdb
63_SAMT_II260824211321605123326a
104
1
7-azaindole
CCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ncn1
CCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ncn1
-13.6
0.4387
79.6
3.6776
411.465
4.1496
92.79
0.5263
2
5
4
31
4
0.25
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccncn5)cc34)ccc21
8
ARG95;PHE175;PRO177;ILE191;ASP202;PHE203;LEU246;TYR249
10
3
5
1
1
0
1
1
1
0.73
1
1
1
14.2482
12.4936
2.842
-5.0835
60.2719
95.9485
-5.0936
0.6757
0.5573
0.0211
0.9768
0.6783
0.6359
structures/63_SAMT_II260824211321605123326a_complex.pdb
63_SAMT_II260824211321605195415a
105
1
7-azaindole
COC(=O)C1([NH2+]Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)CCC1
COC(=O)C1([NH2+]Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)CCC1
-13.6
0.425
73.8
4.1441
431.516
2.164
100.69
0.5391
3
4
5
32
3
0.4
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[NH2+]C5CCC5)cc34)ccc21
6
GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
8
3
4
1
0
0
1
1
0
0.73
1
1
1
27.2981
14.1056
1.8524
-4.1752
26.8794
83.8435
-5.4239
0.9214
0.8606
0.25
0.2362
0.5075
0.4352
structures/63_SAMT_II260824211321605195415a_complex.pdb
63_SAMT_II2608242113216051114686a
106
1
7-azaindole
Nc1nc(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n[nH]1
Nc1nc(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n[nH]1
-13.5
0.45
83.2
3.788
400.446
2.3173
137.4
0.3564
5
6
4
30
4
0.2381
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5nc[nH]n5)cc34)ccc21
9
ARG95;SER173;ILE191;ASP202;PHE203;SER244;LEU245;LEU246;TYR249
15
10
3
1
1
0
1
1
1
0.34
1
1
1
-2.3449
-11.7166
0.7013
-4.4232
58.4843
82.2305
-6.1925
0.7186
0.6468
0.0473
0.9141
0.476
0.3667
structures/63_SAMT_II2608242113216051114686a_complex.pdb
63_SAMT_II260824211321605144189a
107
1
7-azaindole
CC(Cc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1nn[nH]n1
C[C@H](Cc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1nn[nH]n1
-13.5
0.45
77.7
4.1579
399.458
2.8642
112.24
0.4885
3
5
4
30
4
0.3182
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCc5nn[nH]n5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
9
4
4
1
0
0
1
1
0
0.92
1
1
1
-1.999
-9.9728
0.4
-4.0187
25.1255
82.2114
-6.0586
0.4332
0.4694
0.0435
0.9149
0.4421
0.6148
structures/63_SAMT_II260824211321605144189a_complex.pdb
63_SAMT_II260824211321605144769a
108
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5[nH]c(Cl)nc5Cl)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5[nH]c(Cl)nc5Cl)cc34)ccc21
-13.5
0.4219
83.2
3.8921
467.36
4.6894
98.49
0.3424
4
4
5
32
4
0.2609
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5cnc[nH]5)cc34)ccc21
9
ARG95;PHE175;ILE191;ASP202;PHE203;SER244;LEU245;LEU246;TYR249
11
5
3
1
1
1
1
1
1
0.38
1
1
1
11.2276
-9.241
2.6274
-5.0987
102.4882
95.8837
-5.4399
0.9085
0.9299
0.59
0.9061
0.7311
0.6506
structures/63_SAMT_II260824211321605144769a_complex.pdb
63_SAMT_II260824211321605149917a
109
1
7-azaindole
Cc1ccc2[nH]nc(Nc3cc4c(-c5ccc6c(c5)C5(CC5)CNC6=O)ccnc4[nH]3)c2c1
Cc1ccc2[nH]nc(Nc3cc4c(-c5ccc6c(c5)C5(CC5)CNC6=O)ccnc4[nH]3)c2c1
-13.5
0.4091
82.8
3.5653
434.503
4.9332
98.49
0.3235
4
4
3
33
5
0.1923
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c6ccccc56)cc34)ccc21
10
ARG95;ILE96;PRO177;PHE178;ILE191;ASP202;PHE203;SER244;LEU246;TYR249
12
4
6
1
1
0
1
1
1
0.42
1
1
1
27.6724
8.3821
3.5584
-5.6772
121.9408
99.2471
-5.4631
0.9367
0.9745
0.5928
0.964
0.8094
0.4262
structures/63_SAMT_II260824211321605149917a_complex.pdb
63_SAMT_II260824211321605187365a
110
1
7-azaindole
CNc1nc(OC)nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
CNc1nc(OC)nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-13.5
0.4091
76.8
3.7787
443.467
3.0325
126.94
0.4296
3
8
5
33
4
0.2609
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncncn5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
5
1
3
0
1
0
1
0
1
0.48
1
1
1
14.5757
11.7778
2.2898
-5.054
50.9423
94.2693
-5.2232
0.8806
0.9425
0.0816
0.9909
0.6527
0.5479
structures/63_SAMT_II260824211321605187365a_complex.pdb
63_SAMT_II260824211321605100077a
111
1
7-azaindole
C=CC[NH+]=C(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)NC1CC1
C=CC[NH+]=C(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)NC1CC1
-13.4
0.4188
77.8
4.2439
427.532
1.7914
95.81
0.2437
5
2
5
32
3
0.32
1
[NH+]=C(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)NC1CC1
9
ILE96;GLY172;PHE175;ILE191;ASP202;PHE203;SER244;LEU246;TYR249
11
5
5
1
0
0
1
1
0
0.6
1
1
1
8.4017
-30.7262
1.22
-3.9741
74.4052
77.1001
-5.9431
0.9122
0.6098
0.4901
0.3218
0.6556
0.4038
structures/63_SAMT_II260824211321605100077a_complex.pdb
63_SAMT_II2608242113216051111350a
112
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cccc6cn[nH]c56)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cccc6cn[nH]c56)cc34)ccc21
-13.4
0.4061
72
3.6276
434.503
4.4933
98.49
0.3349
4
4
4
33
5
0.1923
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cccc6cn[nH]c56)cc34)ccc21
6
ARG95;PHE175;ILE191;PHE203;LEU246;TYR249
7
1
4
1
1
0
1
1
1
1.14
1
1
1
27.5013
17.297
3.1579
-5.3222
92.3669
98.24
-5.5309
0.9544
0.9906
0.795
0.9299
0.8029
0.5738
structures/63_SAMT_II2608242113216051111350a_complex.pdb
63_SAMT_II2608242113216051117220a
113
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCn5cnnc5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCn5cnnc5)cc34)ccc21
-13.4
0.4467
80.5
3.7401
399.458
2.7085
100.52
0.4791
3
5
5
30
4
0.2727
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCn5cnnc5)cc34)ccc21
7
ARG95;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
11
6
3
1
1
0
1
1
1
0.57
1
1
1
9.2817
0.2236
1.3673
-4.1914
48.6106
79.9717
-5.8651
0.8649
0.9436
0.2229
0.9555
0.7434
0.5809
structures/63_SAMT_II2608242113216051117220a_complex.pdb
63_SAMT_II2608242113216051122377a
114
1
7-azaindole
Cn1cc(S(=O)(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)cn1
Cn1cc(S(=O)(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)cn1
-13.4
0.4188
81.4
3.6132
448.508
2.5392
121.77
0.4429
3
5
4
32
4
0.2273
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NS(=O)(=O)c5cn[nH]c5)cc34)ccc21
7
ARG95;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
10
6
3
1
0
0
1
1
0
0.6
1
1
1
4.0057
-4.6824
0.9435
-4.4538
85.518
90.3173
-5.7283
0.5137
0.6402
0.0497
0.9714
0.1532
0.411
structures/63_SAMT_II2608242113216051122377a_complex.pdb
63_SAMT_II260824211321605171578a
115
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5cnc(=O)[nH]c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5cnc(=O)[nH]c5)cc34)ccc21
-13.4
0.4323
77.9
3.7208
413.437
2.6672
112.76
0.4761
3
5
4
31
4
0.2174
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5cnc(=O)[nH]c5)cc34)ccc21
7
ARG95;SER173;ILE191;PHE203;SER244;LEU246;TYR249
11
6
3
1
1
0
1
1
1
0.78
1
1
1
8.9125
9.9403
1.9226
-4.9947
40.1129
89.7719
-5.4039
0.3309
0.1517
0.0149
0.96
0.3645
0.3474
structures/63_SAMT_II260824211321605171578a_complex.pdb
63_SAMT_II2608242113216051118165a
116
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccc(Br)s5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccc(Br)s5)cc34)ccc21
-13.2
0.4258
79.9
3.566
493.43
5.4835
69.81
0.3448
3
4
5
31
4
0.25
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5cccs5)cc34)ccc21
7
ILE96;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
8
3
4
1
0
0
1
1
0
0.41
1
1
1
17.1542
3.3923
3.6315
-5.6944
120.803
99.8127
-5.1487
0.9382
0.9678
0.8888
0.8608
0.7449
0.7709
structures/63_SAMT_II2608242113216051118165a_complex.pdb
63_SAMT_II2608242113216051128875a
117
1
7-azaindole
Nc1ccc2c(n1)CCC2[NH2+]c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
Nc1ccc2c(n1)CC[C@H]2[NH2+]c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-13.2
0.4
70.6
4.6387
437.527
2.8645
113.3
0.3946
4
4
3
33
4
0.2692
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]C5CCc6ncccc65)cc34)ccc21
8
ARG95;PHE175;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
9
3
5
0
1
0
1
0
1
1.17
1
1
1
6.1158
-11.7021
1.398
-4.2948
69.4913
82.0746
-5.948
0.8907
0.7053
0.2241
0.3108
0.7826
0.2411
structures/63_SAMT_II2608242113216051128875a_complex.pdb
63_SAMT_II260824211321605115178a
118
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCc5cc(F)cc(F)c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCc5cc(F)cc(F)c5)cc34)ccc21
-13.2
0.4125
80.7
3.3848
429.47
5.0683
57.78
0.476
2
2
4
32
4
0.2308
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCc5ccccc5)cc34)ccc21
6
ARG95;PRO177;ILE191;PHE203;LEU246;TYR249
9
3
4
1
1
0
1
1
1
0.37
1
1
1
20.7416
16.8839
3.7607
-5.8901
76.2511
100.9644
-4.8756
0.9342
0.9573
0.6348
0.8157
0.6819
0.8542
structures/63_SAMT_II260824211321605115178a_complex.pdb
63_SAMT_II260824211321605122572a
119
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C(=O)c5cccc6cc[nH]c56)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C(=O)c5cccc6cc[nH]c56)cc34)ccc21
-13.2
0.4
75.6
3.5111
432.483
4.7172
90.64
0.3605
3
3
3
33
5
0.1481
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C(=O)c5cccc6cc[nH]c56)cc34)ccc21
7
ARG95;GLY172;PHE175;ILE191;PHE203;LEU246;TYR249
8
2
4
1
1
0
1
1
1
0.74
1
1
1
22.1424
11.3401
3.3623
-5.8052
110.566
99.505
-5.0592
0.8419
0.7705
0.2587
0.9711
0.778
0.6061
structures/63_SAMT_II260824211321605122572a_complex.pdb
63_SAMT_II260824211321605165488a
120
1
7-azaindole
COc1ccc(OC)c(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1
COc1ccc(OC)c(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1
-13.2
0.4
73.2
3.3084
439.515
4.6129
76.24
0.4761
2
4
5
33
4
0.2593
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccccc5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
6
1
4
0
1
0
1
0
1
1.51
1
1
1
33.9946
22.1612
3.4399
-5.6161
55.4444
100.3298
-5.0433
0.9334
0.9784
0.3341
0.8866
0.5677
0.7383
structures/63_SAMT_II260824211321605165488a_complex.pdb
63_SAMT_II260824211321605170954a
121
1
7-azaindole
Cc1ccc(C(=O)Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)o1
Cc1ccc(C(=O)Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)o1
-13.2
0.4258
80.7
3.5053
411.461
4.3317
87.99
0.4894
2
4
4
31
4
0.24
0
O=C(Cc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccco1
7
ARG95;PHE175;ILE191;ASP202;PHE203;LEU246;TYR249
9
3
4
1
1
0
1
1
1
0.59
1
1
1
21.8272
14.2853
3.06
-5.3308
52.3116
97.7754
-5.0115
0.8418
0.9054
0.2624
0.9074
0.6777
0.7779
structures/63_SAMT_II260824211321605170954a_complex.pdb
63_SAMT_II260824211321605184506a
122
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CC(O)Cn5cnc(=S)[nH]5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[C@H](O)Cn5cnc(=S)[nH]5)cc34)ccc21
-13.2
0.4125
81.5
4.4424
446.536
2.8626
111.62
0.3524
4
5
5
32
4
0.3043
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCCn5cnc(=S)[nH]5)cc34)ccc21
6
ARG95;ILE191;PHE203;SER244;LEU246;TYR249
10
5
3
1
1
0
1
1
1
0.34
1
1
1
-1.2033
-20.3513
-0.0771
-3.6799
25.8679
71.413
-6.5146
0.4605
0.4277
0.0605
0.9103
0.3798
0.258
structures/63_SAMT_II260824211321605184506a_complex.pdb
63_SAMT_II260824211321605191636a
123
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccn5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccn5)cc34)ccc21
-13.2
0.4258
81
3.4186
409.493
4.0545
82.7
0.4643
3
4
5
31
4
0.24
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccn5)cc34)ccc21
9
ARG95;GLY172;PHE175;PRO177;ILE191;PHE203;SER244;LEU246;TYR249
11
4
5
1
1
0
1
1
1
0.67
1
1
1
14.338
11.2411
2.5917
-4.7814
69.555
93.6187
-5.4127
0.9247
0.9039
0.5382
0.8927
0.7411
0.7094
structures/63_SAMT_II260824211321605191636a_complex.pdb
63_SAMT_II2608242113216051103545a
124
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccc(Cl)c(F)c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccc(Cl)c(F)c5)cc34)ccc21
-13.1
0.397
84.3
3.4386
460.94
5.452
69.81
0.3705
3
3
5
33
4
0.2308
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccc5)cc34)ccc21
8
ARG95;PHE175;ILE191;ASP202;PHE203;SER244;LEU246;TYR249
10
4
4
1
1
0
1
1
1
0.39
1
1
1
21.296
7.7948
3.8259
-6.0401
112.0312
101.1327
-5.0515
0.9679
0.974
0.9078
0.8596
0.7333
0.7992
structures/63_SAMT_II2608242113216051103545a_complex.pdb
63_SAMT_II2608242113216051128570a
125
1
7-azaindole
Cc1n[nH]c(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
Cc1n[nH]c(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-13.1
0.4367
81
3.8179
399.458
3.0435
111.38
0.4215
4
5
4
30
4
0.2727
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ncn[nH]5)cc34)ccc21
9
ARG95;ILE96;GLY172;PRO177;ILE191;PHE203;SER244;LEU246;TYR249
12
5
5
1
1
0
1
1
1
0.71
1
1
1
0.0788
-11.0902
1.0636
-4.1666
55.5564
83.1116
-6.0449
0.638
0.4423
0.0206
0.9029
0.638
0.523
structures/63_SAMT_II2608242113216051128570a_complex.pdb
63_SAMT_II260824211321605126235a
126
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCC5C[NH+](CC(F)(F)F)C5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCC5C[NH+](CC(F)(F)F)C5)cc34)ccc21
-13.1
0.397
80.5
4.3502
456.492
2.4938
74.25
0.4768
4
3
5
33
3
0.4167
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCC5C[NH2+]C5)cc34)ccc21
5
ILE191;PHE203;SER244;LEU246;TYR249
7
3
3
1
0
0
1
1
0
0.37
1
1
1
7.8813
-24.8902
1.9821
-4.2125
71.2728
84.9859
-5.6065
0.944
0.6138
0.1169
0.0011
0.3834
0.0238
structures/63_SAMT_II260824211321605126235a_complex.pdb
63_SAMT_II260824211321605137969a
127
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6occc56)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6occc56)cc34)ccc21
-13.1
0.4094
78.2
3.8306
423.432
4.3334
105.93
0.4473
2
6
3
32
5
0.1667
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6occc56)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
7
2
3
1
1
0
1
1
1
0.56
1
1
1
7.1237
3.4589
3.0989
-5.6803
82.7873
98.6875
-4.9505
0.7034
0.6897
0.0641
0.9864
0.6844
0.5149
structures/63_SAMT_II260824211321605137969a_complex.pdb
63_SAMT_II260824211321605150874a
128
1
7-azaindole
CCc1cccc(C)c1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CCc1cccc(C)c1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-13.1
0.397
74.6
3.4985
436.559
5.4878
69.81
0.3875
3
3
5
33
4
0.2857
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccccc5)cc34)ccc21
7
ARG95;PHE175;ILE191;PHE203;SER244;LEU246;TYR249
8
3
4
0
1
0
1
0
1
0.83
1
1
1
47.4987
27.4559
3.8041
-5.4948
83.6725
101.2724
-5.3113
0.9713
0.9575
0.8147
0.8535
0.7956
0.8108
structures/63_SAMT_II260824211321605150874a_complex.pdb
63_SAMT_II260824211321605153083a
129
1
7-azaindole
Cc1nc(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2cc[nH]c2n1
Cc1nc(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c2cc[nH]c2n1
-13.1
0.397
74.5
3.7123
435.491
4.3282
111.38
0.3371
4
5
3
33
5
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5ncnc6[nH]ccc56)cc34)ccc21
6
ARG95;GLY172;ILE191;PHE203;LEU246;TYR249
9
4
3
1
1
0
1
1
1
0.84
1
1
1
13.7519
-4.4076
3.0506
-5.279
118.5448
95.2843
-5.5148
0.9103
0.8869
0.3031
0.9744
0.8618
0.3258
structures/63_SAMT_II260824211321605153083a_complex.pdb
63_SAMT_II260824211321605155689a
130
1
7-azaindole
CC1C[NH2+]CC=C1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
C[C@H]1C[NH2+]CC=C1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-13.1
0.4226
78.9
4.8143
414.533
2.5563
86.42
0.4951
4
3
4
31
3
0.36
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCC5=CC[NH2+]CC5)cc34)ccc21
7
ARG95;GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
9
3
4
1
1
0
1
1
1
0.43
1
1
1
-0.4916
-20.0424
1.4085
-3.7993
72.0355
77.2017
-5.6101
0.939
0.791
0.3469
0.0775
0.484
0.3507
structures/63_SAMT_II260824211321605155689a_complex.pdb
63_SAMT_II260824211321605183510a
131
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6cccs6)n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6cccs6)n5)cc34)ccc21
-13.1
0.397
71.4
3.6967
453.531
4.5951
111.38
0.3179
4
6
4
33
5
0.1667
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6cccs6)n5)cc34)ccc21
6
ARG95;ILE191;PHE203;SER244;LEU246;TYR249
7
2
3
1
1
0
1
1
1
0.85
1
1
1
21.0383
7.5238
2.8967
-5.5263
100.6749
98.1506
-5.5204
0.9184
0.9307
0.594
0.9754
0.7693
0.2948
structures/63_SAMT_II260824211321605183510a_complex.pdb
63_SAMT_II260824211321605184412a
132
1
7-azaindole
O=C1CNC(=O)C(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)N1
O=C1CNC(=O)[C@H](Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)N1
-13.1
0.4226
78.6
4.0567
415.453
1.162
115.98
0.5137
4
4
3
31
3
0.3043
0
O=C1CNC(=O)C(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)N1
7
ARG95;GLY172;SER173;ILE191;PHE203;LEU246;TYR249
8
4
3
1
0
0
1
1
0
0.62
1
1
1
8.9922
-15.9829
1.4374
-3.9127
32.3061
80.4284
-5.738
0.4492
0.2336
0.0298
0.812
0.7061
0.5603
structures/63_SAMT_II260824211321605184412a_complex.pdb
63_SAMT_II260824211321605189789a
133
1
7-azaindole
Nc1nnc(COc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)s1
Nc1nnc(COc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)s1
-13.1
0.4367
80.2
3.6808
418.482
3.0176
118.81
0.4687
3
7
4
30
4
0.2381
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5nncs5)cc34)ccc21
6
ARG95;SER173;ILE191;PHE203;LEU246;TYR249
9
5
3
1
0
0
1
1
0
0.41
1
1
1
7.5412
3.1214
1.5549
-4.4354
40.6705
90.3203
-5.5389
0.6244
0.5668
0.0682
0.9635
0.7547
0.5973
structures/63_SAMT_II260824211321605189789a_complex.pdb
63_SAMT_II260824211321605106669a
134
1
7-azaindole
CCC1CC(=O)NC1Cc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CC[C@@H]1CC(=O)N[C@H]1Cc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-13
0.4194
75.5
4.4719
414.509
3.4621
86.88
0.611
3
3
4
31
3
0.4
0
O=C1CCC(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)N1
7
ARG95;GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
8
2
4
1
1
0
1
1
1
1.03
1
1
1
12.9988
-4.8844
2.1973
-4.6014
41.2131
86.3228
-5.3799
0.7686
0.7587
0.0963
0.8264
0.62
0.754
structures/63_SAMT_II260824211321605106669a_complex.pdb
63_SAMT_II2608242113216051102463a
135
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]C5CC6CC5CC6O)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+][C@H]5C[C@H]6C[C@@H]5C[C@H]6O)cc34)ccc21
-13
0.4194
74.5
5.9458
415.517
2.3592
94.62
0.529
4
3
3
31
3
0.44
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]C5CC6CCC5C6)cc34)ccc21
7
ARG95;GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
10
4
4
1
1
0
1
1
1
0.87
1
1
1
0.8196
-12.3841
1.0818
-4.1394
56.4351
76.1305
-5.862
0.8493
0.3815
0.2333
0.0323
0.4187
0.1737
structures/63_SAMT_II2608242113216051102463a_complex.pdb
63_SAMT_II260824211321605116924a
136
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCC5CCC6OC6C5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OC[C@H]5CC[C@@H]6O[C@@H]6C5)cc34)ccc21
-13
0.4194
75.1
4.5673
415.493
3.9512
79.54
0.6326
2
4
4
31
3
0.44
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCC5CCC6OC6C5)cc34)ccc21
7
ARG95;PHE175;ILE191;PHE203;LEU245;LEU246;TYR249
8
1
5
1
1
0
1
1
1
1.02
1
1
1
24.4451
18.1901
3.3486
-5.3432
61.4778
97.4136
-4.9958
0.8053
0.5673
0.0896
0.8784
0.7948
0.8188
structures/63_SAMT_II260824211321605116924a_complex.pdb
63_SAMT_II260824211321605117244a
137
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6ccoc6)n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6ccoc6)n5)cc34)ccc21
-13
0.3939
68.2
3.8145
437.463
4.1266
124.52
0.3351
4
6
4
33
5
0.1667
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5n[nH]c(-c6ccoc6)n5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
8
3
3
1
1
0
1
1
1
1.1
1
1
1
12.3728
0.1466
2.6122
-5.5193
104.7316
96.6577
-5.5289
0.8999
0.9519
0.4792
0.9775
0.6113
0.2286
structures/63_SAMT_II260824211321605117244a_complex.pdb
63_SAMT_II260824211321605123309a
138
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6[nH]cnc56)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6[nH]cnc56)cc34)ccc21
-13
0.4062
77.1
3.8622
423.436
3.4635
121.47
0.4086
3
6
3
32
5
0.1739
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncnc6[nH]cnc56)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
8
3
3
1
1
0
1
1
1
0.7
1
1
1
4.6391
1.6801
2.1649
-5.0937
79.7213
93.4041
-5.4398
0.5897
0.5129
0.0367
0.9945
0.7722
0.3465
structures/63_SAMT_II260824211321605123309a_complex.pdb
63_SAMT_II260824211321605173958a
139
1
7-azaindole
Nc1nc(N)c(N)c(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
Nc1nc(N)c(N)c(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-13
0.4062
77
3.8112
428.456
2.3338
170.85
0.3307
5
8
3
32
4
0.1818
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccncn5)cc34)ccc21
8
ARG95;GLY172;ILE191;ASP202;PHE203;SER244;LEU246;TYR249
12
7
3
1
1
0
1
1
1
0.83
1
1
1
3.6051
-4.9728
1.7644
-4.9706
59.1828
87.7599
-5.4271
0.7961
0.6032
0.0463
0.9839
0.8174
0.2898
structures/63_SAMT_II260824211321605173958a_complex.pdb
63_SAMT_II260824211321605176423a
140
1
7-azaindole
COc1ccc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c(N)c1
COc1ccc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c(N)c1
-13
0.4062
70.9
3.4069
424.504
4.1865
93.03
0.4285
3
4
4
32
4
0.2308
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccccc5)cc34)ccc21
7
ARG95;GLY172;SER173;ILE191;PHE203;LEU246;TYR249
9
4
3
1
1
0
1
1
1
0.92
1
1
1
19.7012
13.8994
2.7582
-5.2207
53.7932
96.0605
-5.2317
0.9262
0.944
0.403
0.873
0.7411
0.6964
structures/63_SAMT_II260824211321605176423a_complex.pdb
63_SAMT_II260824211321605191865a
141
1
7-azaindole
Nc1cc(C(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n[nH]1
Nc1cc(C(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n[nH]1
-13
0.4194
79.3
3.7207
413.441
2.5625
141.58
0.3509
5
5
3
31
4
0.1818
0
O=C(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1cc[nH]n1
7
ARG95;GLY172;ILE191;PHE203;SER244;LEU246;TYR249
10
5
3
1
1
0
1
1
1
0.3
1
1
1
7.9423
3.5107
2.0258
-5.6042
90.7589
93.0975
-5.6819
0.703
0.5934
0.0585
0.9853
0.7408
0.3466
structures/63_SAMT_II260824211321605191865a_complex.pdb
63_SAMT_II260824211321605104281a
142
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccoc6)n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccoc6)n5)cc34)ccc21
-12.9
0.3909
68.9
3.701
437.459
4.2387
109.84
0.4352
2
6
4
33
5
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccoc6)n5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
7
2
3
1
1
0
1
1
1
1.15
1
1
1
18.6086
8.5367
3.0939
-5.7319
57.1596
100.5078
-5.1094
0.8794
0.9735
0.2053
0.9642
0.6301
0.7224
structures/63_SAMT_II260824211321605104281a_complex.pdb
63_SAMT_II2608242113216051100160a
143
1
7-azaindole
CCNC(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)=[NH+]CC
CCNC(Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)=[NH+]CC
-12.9
0.43
76
4.1452
403.51
1.4828
95.81
0.3369
5
2
4
30
3
0.3478
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]ccc34)ccc21
5
ILE191;PHE203;SER244;LEU246;TYR249
8
4
3
1
0
0
1
1
0
0.77
1
1
1
12.2994
-27.8792
0.8373
-3.3659
81.3913
69.1539
-6.0179
0.8628
0.3399
0.444
0.4067
0.6633
0.4911
structures/63_SAMT_II2608242113216051100160a_complex.pdb
63_SAMT_II2608242113216051105124a
144
1
7-azaindole
CC(C)n1nccc1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CC(C)n1nccc1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.9
0.4031
71.6
3.7034
426.524
4.3944
87.63
0.4415
3
4
5
32
4
0.32
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccn[nH]5)cc34)ccc21
6
ARG95;GLY172;ILE191;PHE203;LEU246;TYR249
9
4
3
1
1
0
1
1
1
1.04
1
1
1
24.2313
10.8543
2.8238
-4.8398
83.3137
93.2269
-5.4611
0.9528
0.9613
0.4293
0.9104
0.7016
0.6177
structures/63_SAMT_II2608242113216051105124a_complex.pdb
63_SAMT_II2608242113216051106131a
145
1
7-azaindole
CONC(=O)C(=O)Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CONC(=O)C(=O)Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.9
0.43
79.3
3.6583
405.414
1.621
125.21
0.3893
4
5
3
30
3
0.2381
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]ccc34)ccc21
5
GLY172;ILE191;PHE203;LEU246;TYR249
6
2
3
1
0
0
1
1
0
0.83
1
1
1
1.4882
-6.4111
1.5526
-4.567
65.5381
85.3383
-5.4704
0.4211
0.1032
0.0173
0.9844
0.818
0.5427
structures/63_SAMT_II2608242113216051106131a_complex.pdb
63_SAMT_II2608242113216051116288a
146
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cnc6ccccc6n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cnc6ccccc6n5)cc34)ccc21
-12.9
0.3909
66.1
3.4467
431.499
4.5389
83.56
0.4394
2
4
3
33
5
0.1852
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cnc6ccccc6n5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
9
3
4
1
1
0
1
1
1
1.62
1
1
1
23.6418
15.5997
3.1316
-5.1906
52.5111
98.5265
-5.2601
0.8769
0.9272
0.1893
0.9549
0.5911
0.7028
structures/63_SAMT_II2608242113216051116288a_complex.pdb
63_SAMT_II2608242113216051130053a
147
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCC(=O)N5CCSCC5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCC(=O)N5CCSCC5)cc34)ccc21
-12.9
0.3909
68.3
3.6229
461.591
3.3823
90.12
0.542
3
5
5
33
3
0.4
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCC(=O)N5CCSCC5)cc34)ccc21
5
GLY172;ILE191;PHE203;LEU246;TYR249
5
2
2
1
0
0
1
1
0
1.01
1
1
1
25.2848
14.9489
2.0621
-4.5847
58.2097
86.2914
-5.5221
0.8605
0.7022
0.1754
0.8258
0.7955
0.8193
structures/63_SAMT_II2608242113216051130053a_complex.pdb
63_SAMT_II2608242113216051131798a
148
1
7-azaindole
Cc1n[nH]c(=O)nc1NCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
Cc1n[nH]c(=O)nc1NCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.9
0.4031
78.4
3.6558
427.468
2.4037
128.45
0.3959
4
6
4
32
4
0.2609
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CNc5cn[nH]c(=O)n5)cc34)ccc21
6
ARG95;ILE191;ASP202;PHE203;LEU246;TYR249
9
4
3
1
1
0
1
1
1
0.51
1
1
1
10.0993
-2.9668
1.288
-4.8996
40.6576
87.9095
-5.826
0.4212
0.3458
0.0134
0.9699
0.3125
0.511
structures/63_SAMT_II2608242113216051131798a_complex.pdb
63_SAMT_II260824211321605122973a
149
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(c5)CCCC6)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(c5)CCCC6)cc34)ccc21
-12.9
0.3909
67.4
3.3749
433.555
5.4745
57.78
0.4498
2
2
3
33
4
0.3103
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(c5)CCCC6)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
7
1
4
1
1
0
1
1
1
1.87
1
1
0.78
35.8876
19.7399
3.8453
-5.6623
68.1511
101.8451
-5.1433
0.9291
0.9444
0.517
0.7714
0.6662
0.8487
structures/63_SAMT_II260824211321605122973a_complex.pdb
63_SAMT_II260824211321605123386a
150
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH+]5CCCC5CC5CCCC5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH+]5CCC[C@@H]5CC5CCCC5)cc34)ccc21
-12.9
0.3909
60.5
4.9683
441.599
4.264
62.22
0.5664
3
2
4
33
3
0.5
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH+]5CCCC5CC5CCCC5)cc34)ccc21
5
ILE191;ASP202;PHE203;LEU246;TYR249
6
3
3
0
0
0
1
0
0
4.35
1
1
0.33
18.4424
-5.1468
2.4337
-4.8576
78.4912
93.2034
-5.6
0.9521
0.6634
0.4056
0.0207
0.3666
0.1685
structures/63_SAMT_II260824211321605123386a_complex.pdb
63_SAMT_II260824211321605126277a
151
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(-c5cc(=O)n6nccc6[nH]5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(-c5cc(=O)n6nccc6[nH]5)cc34)ccc21
-12.9
0.4031
74
3.8391
422.448
3.0079
107.94
0.4064
3
4
2
32
5
0.1667
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(-c5cc(=O)n6nccc6[nH]5)cc34)ccc21
5
ARG95;GLY172;ILE191;LEU246;TYR249
8
4
3
1
0
0
0
1
0
1.12
1
1
1
6.1137
0.0075
2.1482
-5.6936
87.5724
94.2688
-5.4902
0.6853
0.5393
0.086
0.9791
0.5978
0.4159
structures/63_SAMT_II260824211321605126277a_complex.pdb
63_SAMT_II260824211321605136130a
152
1
7-azaindole
Cc1ccc(CC(C)[NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)s1
Cc1ccc(C[C@@H](C)[NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)s1
-12.9
0.4031
67.4
4.4938
443.596
4.2009
74.39
0.4324
3
3
5
32
4
0.3077
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]CCc5cccs5)cc34)ccc21
6
GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
9
4
4
1
0
0
1
1
0
1.34
1
1
1
16.2784
-0.1349
2.4637
-4.6796
68.3815
94.4684
-5.5212
0.9615
0.9206
0.7105
0.4025
0.6207
0.4105
structures/63_SAMT_II260824211321605136130a_complex.pdb
63_SAMT_II260824211321605142147a
153
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5cccc(F)c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5cccc(F)c5)cc34)ccc21
-12.9
0.4031
67.8
3.3588
426.495
4.7986
69.81
0.4294
3
3
5
32
4
0.2308
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccc5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
8
2
4
1
1
0
1
1
1
1.59
1
1
1
24.656
16.8267
3.5826
-5.7331
83.7373
100.9029
-5.1147
0.9689
0.9708
0.8941
0.8553
0.82
0.8289
structures/63_SAMT_II260824211321605142147a_complex.pdb
63_SAMT_II260824211321605150447a
154
1
7-azaindole
O=C(CCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1cccc(F)c1
O=C(CCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1cccc(F)c1
-12.9
0.3909
80.6
3.326
439.49
4.9595
74.85
0.4318
2
3
5
33
4
0.2222
0
O=C(CCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccccc1
8
ILE96;PRO177;PHE178;ILE191;ASP202;PHE203;LEU246;TYR249
9
2
6
1
0
0
1
1
0
0.23
1
1
1
25.3502
21.7254
3.4083
-5.728
62.4064
100.5392
-4.9678
0.9105
0.9401
0.4672
0.8777
0.5579
0.8361
structures/63_SAMT_II260824211321605150447a_complex.pdb
63_SAMT_II260824211321605155656a
155
1
7-azaindole
O=C([O-])c1cc(Br)cc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
O=C([O-])c1cc(Br)cc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-12.9
0.3909
74.1
3.9264
502.348
3.1167
110.8
0.4458
2
5
4
33
4
0.2
-1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccccn5)cc34)ccc21
6
ARG95;PHE175;ILE191;PHE203;LEU246;TYR249
8
1
4
1
1
0
1
1
1
1.04
1
1
1
-4.8001
-5.2199
1.5749
-4.9312
81.6902
95.2465
-5.2289
0.3567
0.2813
0.0222
0.9882
0.3739
0.4509
structures/63_SAMT_II260824211321605155656a_complex.pdb
63_SAMT_II260824211321605157596a
156
1
7-azaindole
COCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccc1[O-]
COCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccc1[O-]
-12.9
0.3909
75.1
3.8703
440.479
4.0172
99.3
0.4884
2
5
5
33
4
0.2308
-1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccccc5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
6
1
4
0
1
0
0
0
1
1.42
1
1
1
17.7885
19.9368
2.8846
-5.0966
61.1549
95.766
-4.9801
0.8041
0.7207
0.1241
0.939
0.724
0.629
structures/63_SAMT_II260824211321605157596a_complex.pdb
63_SAMT_II260824211321605159146a
157
1
7-azaindole
Cc1cnc(C)c(NCc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
Cc1cnc(C)c(NCc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-12.9
0.4031
79.7
3.5593
424.508
4.0238
95.59
0.4598
3
5
4
32
4
0.28
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CNc5cnccn5)cc34)ccc21
6
ARG95;ILE191;ASP202;PHE203;LEU246;TYR249
9
4
3
1
1
0
1
1
1
0.3
1
1
1
26.4133
10.9413
2.625
-4.7068
50.2287
92.3067
-5.4778
0.9088
0.9102
0.1706
0.9317
0.7469
0.7029
structures/63_SAMT_II260824211321605159146a_complex.pdb
63_SAMT_II260824211321605159762a
158
1
7-azaindole
NC(=O)c1nc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)cnc1N
NC(=O)c1nc(Cc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)cnc1N
-12.9
0.3909
64.7
3.698
439.479
2.0668
152.67
0.3818
4
6
4
33
4
0.2083
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cnccn5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
8
4
3
0
1
0
1
0
1
2.22
1
1
0.89
19.0924
6.1672
2.1626
-5.0163
48.5673
89.5846
-5.5734
0.6885
0.5656
0.0387
0.9736
0.7388
0.5125
structures/63_SAMT_II260824211321605159762a_complex.pdb
63_SAMT_II260824211321605163381a
159
1
7-azaindole
O=C(Cc1cnccn1)NCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
O=C(Cc1cnccn1)NCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.9
0.3909
66.4
3.4829
438.491
2.6538
112.66
0.4435
3
5
5
33
4
0.24
0
O=C(Cc1cnccn1)NCc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
5
ILE191;PHE203;LEU245;LEU246;TYR249
5
1
4
0
0
0
1
0
0
1.93
1
1
0.89
14.7921
-0.5867
1.4042
-3.9916
31.675
76.5622
-5.7767
0.6856
0.911
0.048
0.9506
0.2252
0.608
structures/63_SAMT_II260824211321605163381a_complex.pdb
63_SAMT_II260824211321605189047a
160
1
7-azaindole
Cc1[nH]c(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c(Br)c1Br
Cc1[nH]c(CNc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c(Br)c1Br
-12.9
0.4031
82.7
3.8953
555.274
5.7785
85.6
0.2578
4
3
4
32
4
0.25
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccc[nH]5)cc34)ccc21
7
ARG95;GLY172;ILE191;PHE203;SER244;LEU246;TYR249
11
5
3
1
1
1
1
1
1
0.41
1
1
1
37.9303
13.3909
3.6899
-5.8392
116.6749
100.6008
-5.253
0.9257
0.9765
0.7717
0.8718
0.6384
0.7353
structures/63_SAMT_II260824211321605189047a_complex.pdb
63_SAMT_II260824211321605190297a
161
1
7-azaindole
COc1cccnc1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
COc1cccnc1CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.9
0.4031
78
3.5281
425.492
4.0206
91.93
0.4492
3
5
5
32
4
0.24
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccccn5)cc34)ccc21
7
ARG95;PHE175;ILE191;PHE203;SER244;LEU246;TYR249
9
3
4
1
1
0
1
1
1
0.47
1
1
1
20.9096
16.0881
2.6271
-4.9804
65.774
94.2489
-5.3549
0.9295
0.9321
0.3587
0.9206
0.8166
0.7004
structures/63_SAMT_II260824211321605190297a_complex.pdb
63_SAMT_II2608242113216051101169a
162
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccc(Br)o5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccc(Br)o5)cc34)ccc21
-12.8
0.4267
80.7
3.5707
463.335
4.9725
82.95
0.3992
3
4
4
30
4
0.2174
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccco5)cc34)ccc21
7
ARG95;GLY172;ILE191;PHE203;SER244;LEU246;TYR249
9
4
3
1
1
0
1
1
1
0.67
1
1
1
16.6935
9.3229
3.3733
-5.3953
109.6403
98.017
-5.1524
0.9346
0.9617
0.7917
0.8939
0.8248
0.7852
structures/63_SAMT_II2608242113216051101169a_complex.pdb
63_SAMT_II2608242113216051117500a
163
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C5C[NH+]5Cc5ccccc5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([C@H]5C[NH+]5Cc5ccccc5)cc34)ccc21
-12.8
0.4
68.4
4.698
421.524
3.1447
62.22
0.4435
3
2
4
32
4
0.2593
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C5C[NH+]5Cc5ccccc5)cc34)ccc21
6
ILE191;PHE203;LEU245;LEU246;TYR249;PRO278
9
2
5
1
1
0
1
1
0
2.12
1
1
0.78
30.1006
9.8554
2.8116
-4.9037
47.648
94.8488
-5.4189
0.942
0.6251
0.3519
0.0102
0.4638
0.0628
structures/63_SAMT_II2608242113216051117500a_complex.pdb
63_SAMT_II260824211321605115848a
164
1
7-azaindole
[NH3+]C1CC[NH+](CCOc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)C1
[NH3+][C@H]1CC[NH+](CCOc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)C1
-12.8
0.4129
79
5.3796
419.529
0.2828
99.09
0.4782
4
3
5
31
3
0.4167
2
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCC[NH+]5CCCC5)cc34)ccc21
7
ARG95;PHE175;ILE191;PHE203;SER244;LEU246;TYR249
9
3
4
1
1
0
1
1
1
0.52
1
1
1
2.8092
-8.4546
0.4691
-3.1611
51.7472
63.7654
-5.7273
0.8274
0.4013
0.0193
0.0004
0.3617
0.0148
structures/63_SAMT_II260824211321605115848a_complex.pdb
63_SAMT_II260824211321605123255a
165
1
7-azaindole
C[NH+]1CCC([NH+](C)CCc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)CC1
C[NH+]1CCC([NH+](C)CCc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)CC1
-12.8
0.3879
63.9
5.2533
445.611
0.7392
66.66
0.4681
4
2
5
33
3
0.4815
2
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CC[NH2+]C5CC[NH2+]CC5)cc34)ccc21
5
ILE191;PHE203;LEU245;LEU246;TYR249
6
2
4
0
0
0
1
0
0
2.24
1
1
0.78
-6.8913
-14.2814
-1.8135
-2.1202
51.1308
22.2902
-6.5241
0.6823
0.0775
0.0202
0.0018
0.2366
0.0179
structures/63_SAMT_II260824211321605123255a_complex.pdb
63_SAMT_II260824211321605131212a
166
1
7-azaindole
CCC(=O)C(c1ccccc1)c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CCC(=O)[C@H](c1ccccc1)c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.8
0.3879
77.5
3.8984
435.527
5.1159
74.85
0.4571
2
3
5
33
4
0.25
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccccc5)cc34)ccc21
8
ILE191;VAL192;PHE203;LEU204;LEU246;LEU247;TYR249;PRO251
9
2
6
1
0
0
1
1
0
4.09
1
1
0.33
20.9185
3.7485
3.5363
-5.7518
71.258
99.6874
-4.9958
0.8319
0.847
0.2501
0.8344
0.5259
0.6935
structures/63_SAMT_II260824211321605131212a_complex.pdb
63_SAMT_II260824211321605141804a
167
1
7-azaindole
CC1CC(O)C([NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)C(O)C1
C[C@H]1C[C@@H](O)[C@H]([NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)[C@H](O)C1
-12.8
0.4
76.1
4.9262
433.532
1.7201
114.85
0.4326
5
4
3
32
3
0.44
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]C5CCCCC5)cc34)ccc21
7
ARG95;GLY172;ILE191;PHE203;LEU245;LEU246;TYR249
10
4
4
1
1
0
1
1
1
0.82
1
1
1
8.656
-9.9919
1.1844
-3.9847
49.0986
78.2904
-6.1001
0.7228
0.2274
0.0908
0.0092
0.2438
0.0416
structures/63_SAMT_II260824211321605141804a_complex.pdb
63_SAMT_II260824211321605143881a
168
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5cc(Cl)ccc5Cl)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5cc(Cl)ccc5Cl)cc34)ccc21
-12.8
0.4
79.8
3.4394
464.352
5.8907
67.01
0.3959
2
3
4
32
4
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(OCc5ccccc5)cc34)ccc21
6
ARG95;PHE175;ILE191;PHE203;LEU246;TYR249
8
2
4
1
1
0
1
1
1
0.66
1
1
1
29.4455
15.1614
3.8946
-6.1047
131.24
100.3285
-5.0076
0.9008
0.9002
0.6027
0.8886
0.5924
0.7899
structures/63_SAMT_II260824211321605143881a_complex.pdb
63_SAMT_II260824211321605146745a
169
1
7-azaindole
CC(C)(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccccc1
CC(C)(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccccc1
-12.8
0.3879
67.8
3.4776
436.559
5.3946
69.81
0.3926
3
3
5
33
4
0.2857
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCCc5ccccc5)cc34)ccc21
7
ARG95;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
8
3
4
0
1
0
1
0
1
1.29
1
1
1
35.294
17.1
3.7356
-5.7161
80.6029
101.7579
-5.1759
0.9677
0.9498
0.8592
0.809
0.5781
0.7055
structures/63_SAMT_II260824211321605146745a_complex.pdb
63_SAMT_II260824211321605157365a
170
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cccc(F)c5Cl)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cccc(F)c5Cl)cc34)ccc21
-12.8
0.4
74
3.4884
446.913
5.4095
69.81
0.3923
3
3
4
32
4
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccccc5)cc34)ccc21
7
ARG95;GLY172;PHE175;ILE191;PHE203;LEU246;TYR249
8
2
4
1
1
0
1
1
1
0.93
1
1
1
28.427
18.176
3.68
-5.74
96.4853
99.9384
-5.1004
0.951
0.9444
0.7657
0.8924
0.7857
0.7907
structures/63_SAMT_II260824211321605157365a_complex.pdb
63_SAMT_II260824211321605166496a
171
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[NH2+]Cc5nccs5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[NH2+]Cc5nccs5)cc34)ccc21
-12.8
0.4267
81.3
4.1341
416.53
2.725
87.28
0.4675
3
4
5
30
4
0.2609
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[NH2+]Cc5nccs5)cc34)ccc21
7
ARG95;GLY172;ILE191;ASP202;PHE203;LEU246;TYR249
9
5
3
1
0
0
1
1
0
0.7
1
1
1
15.3005
7.9005
1.3505
-3.9398
28.1531
80.3228
-5.6253
0.9047
0.8645
0.2026
0.118
0.6154
0.1837
structures/63_SAMT_II260824211321605166496a_complex.pdb
63_SAMT_II260824211321605168603a
172
1
7-azaindole
CNC(=O)CC(=O)Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
CNC(=O)CC(=O)Nc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.8
0.4267
80.3
3.5299
403.442
2.0795
115.98
0.4992
4
4
4
30
3
0.2727
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]ccc34)ccc21
7
GLY172;ILE191;ASP202;PHE203;SER244;LEU246;TYR249
8
4
3
1
0
0
1
1
0
0.54
1
1
1
0.4661
-2.3892
1.2317
-4.4687
54.9325
82.024
-5.5764
0.6433
0.4458
0.071
0.9292
0.7297
0.6366
structures/63_SAMT_II260824211321605168603a_complex.pdb
63_SAMT_II260824211321605169319a
173
1
7-azaindole
[NH3+]C1(c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)Cc2ccc(Cl)cc2C1
[NH3+][C@@]1(c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)Cc2ccc(Cl)cc2C1
-12.8
0.3879
69.2
4.4184
455.969
3.8943
85.42
0.428
3
2
2
33
4
0.2593
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C5Cc6ccccc6C5)cc34)ccc21
8
ARG95;GLY172;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
10
4
4
1
1
0
1
1
1
1.32
1
1
0.89
12.3746
-7.6353
3.1956
-4.9455
100.2496
96.6063
-5.2606
0.9219
0.6651
0.5135
0.2154
0.4181
0.4522
structures/63_SAMT_II260824211321605169319a_complex.pdb
63_SAMT_II260824211321605195226a
174
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CC5C[NH+](C6CC6)CC[NH2+]5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(C[C@@H]5C[NH+](C6CC6)CC[NH2+]5)cc34)ccc21
-12.8
0.4
79.5
5.4813
429.568
0.5403
78.83
0.4886
4
2
4
32
3
0.4615
2
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CC5C[NH+](C6CC6)CC[NH2+]5)cc34)ccc21
6
PHE175;PRO177;ILE191;PHE203;LEU246;TYR249
8
2
5
1
0
0
1
1
0
0.71
1
1
1
4.2405
-10.3512
0.2095
-3.4509
37.4038
59.8449
-6.0669
0.8963
0.3576
0.0436
0.0002
0.1872
0.0133
structures/63_SAMT_II260824211321605195226a_complex.pdb
63_SAMT_II260824211321605102764a
175
1
7-azaindole
CC([NH2+]c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1cc2n(n1)CCC2
C[C@@H]([NH2+]c1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1cc2n(n1)CCC2
-12.7
0.3848
69.1
4.7305
439.543
3.1037
92.21
0.4563
3
3
4
33
4
0.3462
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]Cc5cc6n(n5)CCC6)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
8
2
4
1
1
0
1
1
1
1.68
1
1
1
11.349
-7.9533
1.5843
-4.0931
58.8354
82.8829
-5.8048
0.871
0.5463
0.1824
0.2115
0.4769
0.2689
structures/63_SAMT_II260824211321605102764a_complex.pdb
63_SAMT_II2608242113216051101417a
176
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cc([O-])c([O-])c(Br)c5Br)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cc([O-])c([O-])c(Br)c5Br)cc34)ccc21
-12.7
0.3848
73.9
4.2115
567.237
4.2679
103.9
0.3863
2
4
3
33
4
0.2
-2
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccccc5)cc34)ccc21
8
ARG95;GLY172;CYS174;ILE191;ASP202;PHE203;LEU246;TYR249
9
2
3
1
1
2
1
1
1
0.97
1
1
0.89
23.5497
15.0466
2.9037
-5.3748
66.2531
98.1855
-5.03
0.6093
0.871
0.1771
0.9466
0.4834
0.5054
structures/63_SAMT_II2608242113216051101417a_complex.pdb
63_SAMT_II2608242113216051102216a
177
1
7-azaindole
COc1nc(Cl)c(C)c(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
COc1nc(Cl)c(C)c(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-12.7
0.3848
73.5
3.7168
460.925
4.5089
104.82
0.3869
3
6
4
33
4
0.25
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5ccncn5)cc34)ccc21
7
ARG95;GLY172;ILE191;ASP202;PHE203;LEU246;TYR249
10
5
3
1
1
0
1
1
1
1.09
1
1
1
17.8883
2.2154
3.2863
-5.4884
106.2612
97.0804
-5.1369
0.9174
0.9525
0.2099
0.9851
0.716
0.5365
structures/63_SAMT_II2608242113216051102216a_complex.pdb
63_SAMT_II2608242113216051118588a
178
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccc(C(F)F)cc5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccc(C(F)F)cc5)cc34)ccc21
-12.7
0.3848
70.9
3.4839
444.485
5.5546
69.81
0.3778
3
3
5
33
4
0.2308
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5ccccc5)cc34)ccc21
7
ARG95;GLY172;PHE175;ILE191;PHE203;LEU246;TYR249
8
2
4
1
1
0
1
1
1
0.94
1
1
1
23.4498
10.7496
3.5653
-5.6756
95.2828
100.1505
-5.2428
0.9638
0.9418
0.7414
0.881
0.8091
0.7516
structures/63_SAMT_II2608242113216051118588a_complex.pdb
63_SAMT_II2608242113216051119657a
179
1
7-azaindole
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccsc1
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccsc1
-12.7
0.4097
71.9
3.6185
428.517
4.3612
86.88
0.4123
3
5
5
31
4
0.2083
0
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccsc1
5
ILE191;PHE203;SER244;LEU246;TYR249
6
2
3
1
0
0
1
1
0
1.1
1
1
1
23.5641
21.052
2.7074
-5.321
67.4455
97.8381
-5.3109
0.9293
0.9385
0.6531
0.9126
0.804
0.732
structures/63_SAMT_II2608242113216051119657a_complex.pdb
63_SAMT_II2608242113216051124517a
180
1
7-azaindole
C=Cc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccc1F
C=Cc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccc1F
-12.7
0.3969
79
3.6133
425.463
5.5793
67.01
0.4486
2
3
4
32
4
0.1538
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccccc5)cc34)ccc21
7
ARG95;PHE175;PRO177;ILE191;PHE203;LEU246;TYR249
9
2
5
1
1
0
1
1
1
0.58
1
1
1
24.5296
18.9717
3.8505
-6.3444
87.7378
102.1975
-4.7654
0.8031
0.8191
0.2731
0.9168
0.6779
0.6604
structures/63_SAMT_II2608242113216051124517a_complex.pdb
63_SAMT_II2608242113216051133338a
181
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5cncc(C#CCO)c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5cncc(C#CCO)c5)cc34)ccc21
-12.7
0.3848
65.4
3.7612
436.471
3.536
100.13
0.4268
3
5
3
33
4
0.1923
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5cccnc5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
7
1
4
1
1
0
1
1
1
1.46
1
1
1
2.059
-1.3314
2.59
-5.2595
88.013
97.2624
-5.1338
0.7736
0.9096
0.1705
0.9518
0.3446
0.3336
structures/63_SAMT_II2608242113216051133338a_complex.pdb
63_SAMT_II2608242113216051134098a
182
1
7-azaindole
NC(=O)Cc1cccc(-c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1F
NC(=O)Cc1cccc(-c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1F
-12.7
0.3848
71.1
3.4582
440.478
3.8388
100.87
0.4494
3
3
4
33
4
0.1923
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(-c5ccccc5)cc34)ccc21
5
ILE191;PHE203;LEU246;LEU247;TYR249
6
1
5
0
0
0
0
0
0
4.04
1
1
0.33
10.0741
0.6306
2.603
-5.1823
65.311
94.1791
-5.202
0.8124
0.611
0.1455
0.9063
0.7091
0.6709
structures/63_SAMT_II2608242113216051134098a_complex.pdb
63_SAMT_II260824211321605133442a
183
1
7-azaindole
CCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccn1
CCc1cc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ccn1
-12.7
0.4097
76.9
3.5548
410.477
4.7546
79.9
0.5086
2
4
4
31
4
0.24
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccncc5)cc34)ccc21
7
ARG95;PHE175;ILE191;PHE203;LEU245;LEU246;TYR249
9
2
5
1
1
0
1
1
1
1.19
1
1
1
17.3223
17.8917
3.1197
-5.276
66.8233
97.7984
-4.9996
0.8405
0.8196
0.1044
0.9548
0.6512
0.686
structures/63_SAMT_II260824211321605133442a_complex.pdb
63_SAMT_II260824211321605148687a
184
1
7-azaindole
Cc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ncc1F
Cc1nc(Oc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)ncc1F
-12.7
0.4097
79.6
3.733
415.428
4.0347
92.79
0.527
2
5
3
31
4
0.2174
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ncccn5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
8
3
3
1
1
0
1
1
1
0.74
1
1
1
14.8525
10.5038
2.9434
-5.2579
60.2006
96.4502
-4.9185
0.7965
0.7844
0.0457
0.9824
0.7426
0.7467
structures/63_SAMT_II260824211321605148687a_complex.pdb
63_SAMT_II260824211321605164964a
185
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cccc6occc56)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cccc6occc56)cc34)ccc21
-12.7
0.3969
71.9
3.4579
419.484
5.3419
70.92
0.4146
2
3
3
32
5
0.1852
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5cccc6occc56)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
8
2
4
1
1
0
1
1
1
1.37
1
1
1
16.2317
7.6813
3.6136
-5.763
91.3717
101.0382
-5.0061
0.9214
0.9441
0.5724
0.8765
0.6948
0.796
structures/63_SAMT_II260824211321605164964a_complex.pdb
63_SAMT_II260824211321605175488a
186
1
7-azaindole
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccco1
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccco1
-12.7
0.4097
79.1
3.5766
412.449
3.8927
100.02
0.4319
3
5
5
31
4
0.2083
0
O=C(CNc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1)c1ccco1
8
ARG95;ILE96;PHE175;PRO177;ILE191;PHE203;LEU246;TYR249
9
1
6
1
1
0
1
1
1
0.66
1
1
1
13.8415
10.4027
2.493
-5.1569
68.0581
95.5374
-5.2744
0.8993
0.8365
0.3853
0.9316
0.7889
0.7405
structures/63_SAMT_II260824211321605175488a_complex.pdb
63_SAMT_II260824211321605184632a
187
1
7-azaindole
COc1cccc(F)c1Oc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
COc1cccc(F)c1Oc1cc2c(-c3ccc4c(c3)C3(CC3)CNC4=O)ccnc2[nH]1
-12.7
0.3969
73
3.4756
429.451
4.9449
76.24
0.4816
2
4
4
32
4
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Oc5ccccc5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
6
1
3
1
1
0
1
1
1
1.1
1
1
1
21.1585
16.4499
3.4977
-5.8317
74.6084
99.6076
-4.7444
0.8584
0.8174
0.1777
0.9384
0.668
0.7505
structures/63_SAMT_II260824211321605184632a_complex.pdb
63_SAMT_II260824211321605195517a
188
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5nnc(C6CCOC6)o5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5nnc([C@@H]6CCOC6)o5)cc34)ccc21
-12.7
0.3848
67.5
4.1649
441.491
3.4826
105.93
0.5023
2
6
4
33
4
0.36
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5nnc(C6CCOC6)o5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
6
1
3
1
1
0
1
1
1
1.27
1
1
1
5.1251
-5.2035
2.0268
-4.6162
42.7678
89.9294
-5.3517
0.6392
0.6764
0.0304
0.929
0.6896
0.7572
structures/63_SAMT_II260824211321605195517a_complex.pdb
63_SAMT_II260824211321605197826a
189
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5n[nH]c(-c6cccs6)n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5n[nH]c(-c6cccs6)n5)cc34)ccc21
-12.7
0.3848
67.8
3.7106
452.543
4.4423
99.35
0.3753
3
5
4
33
5
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5n[nH]c(-c6cccs6)n5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
7
2
3
1
1
0
1
1
1
1.18
1
1
1
17.0104
6.8379
2.5374
-5.1561
59.3994
96.9856
-5.5445
0.9089
0.9634
0.3659
0.9383
0.6051
0.579
structures/63_SAMT_II260824211321605197826a_complex.pdb
63_SAMT_II260824211321605101073a
190
1
7-azaindole
Cc1csc(S(=O)(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1
Cc1csc(S(=O)(=O)Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)c1
-12.6
0.3937
78.9
3.6574
464.572
4.1756
103.95
0.4215
3
5
4
32
4
0.2174
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NS(=O)(=O)c5cccs5)cc34)ccc21
5
PHE178;ILE191;PHE203;LEU246;TYR249
7
2
4
1
0
0
1
1
0
0.73
1
1
1
19.6607
9.4928
1.7877
-5.0244
88.7039
98.5302
-5.5636
0.8787
0.9713
0.5093
0.9448
0.424
0.5367
structures/63_SAMT_II260824211321605101073a_complex.pdb
63_SAMT_II260824211321605102101a
191
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCC5Cc6ccccc6C5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCC5Cc6ccccc6C5)cc34)ccc21
-12.6
0.3818
58.8
3.426
433.555
5.3525
57.78
0.4556
2
2
4
33
4
0.3103
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(CCC5Cc6ccccc6C5)cc34)ccc21
6
ILE191;VAL192;ASP202;PHE203;LEU246;TYR249
7
3
4
0
0
0
1
0
0
4.95
1
1
0.22
31.2592
15.2023
3.8223
-5.6348
66.1658
101.9588
-5.1448
0.9524
0.951
0.7274
0.7975
0.7043
0.897
structures/63_SAMT_II260824211321605102101a_complex.pdb
63_SAMT_II260824211321605103564a
192
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cnc6ccnn6c5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cnc6ccnn6c5)cc34)ccc21
-12.6
0.3818
69.5
3.7144
435.491
3.6597
100
0.4001
3
5
4
33
5
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(NCc5cnc6ccnn6c5)cc34)ccc21
7
ARG95;PHE175;ILE191;ASP202;PHE203;LEU246;TYR249
9
3
4
1
1
0
1
1
1
1.16
1
1
1
16.7609
6.1124
2.4188
-4.7234
81.3468
91.2182
-5.6576
0.8249
0.8135
0.0978
0.9799
0.5047
0.5253
structures/63_SAMT_II260824211321605103564a_complex.pdb
63_SAMT_II260824211321605127628a
193
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(n5)OCCN6)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(n5)OCCN6)cc34)ccc21
-12.6
0.3818
70.1
3.8215
437.503
3.795
91.93
0.4536
3
5
3
33
4
0.2692
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5ccc6c(n5)OCCN6)cc34)ccc21
7
ARG95;ILE191;ASP202;PHE203;LEU245;LEU246;TYR249
9
3
4
1
1
0
1
1
1
1.23
1
1
1
17.772
12.2911
2.7572
-5.1284
56.1866
95.786
-5.2728
0.8684
0.9269
0.193
0.9156
0.5542
0.7418
structures/63_SAMT_II260824211321605127628a_complex.pdb
63_SAMT_II260824211321605155978b
194
1
7-azaindole
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccco6)n5)cc34)ccc21
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccco6)n5)cc34)ccc21
-12.6
0.3818
67.3
3.6077
437.459
4.2387
109.84
0.4352
2
6
4
33
5
0.2
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Cc5noc(-c6ccco6)n5)cc34)ccc21
5
ARG95;ILE191;PHE203;LEU246;TYR249
6
1
3
1
1
0
1
1
1
1.25
1
1
0.89
18.6666
8.9122
3.0248
-5.5412
53.7315
99.5325
-5.1103
0.8699
0.9595
0.2078
0.964
0.7058
0.7545
structures/63_SAMT_II260824211321605155978b_complex.pdb
63_SAMT_II260824211321605159456b
195
1
7-azaindole
Cc1n[nH]c(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
Cc1n[nH]c(Nc2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)n1
-12.6
0.4345
74.1
3.8433
385.431
3.175
111.38
0.4328
4
5
3
29
4
0.2381
0
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c(Nc5ncn[nH]5)cc34)ccc21
7
ARG95;ILE191;PHE203;SER244;LEU245;LEU246;TYR249
9
4
4
1
0
0
1
1
0
0.97
1
1
1
-2.0605
-10.0277
1.4656
-4.7067
72.702
88.445
-5.8301
0.7259
0.5122
0.0941
0.9443
0.7206
0.384
structures/63_SAMT_II260824211321605159456b_complex.pdb
63_SAMT_II260824211321605189351a
196
1
7-azaindole
CC(=O)N1CCCC([NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)C1
CC(=O)N1CCC[C@H]([NH2+]c2cc3c(-c4ccc5c(c4)C4(CC4)CNC5=O)ccnc3[nH]2)C1
-12.6
0.3937
74.2
4.5212
430.532
2.2107
94.7
0.5946
3
3
3
32
3
0.4
1
O=C1NCC2(CC2)c2cc(-c3ccnc4[nH]c([NH2+]C5CCCNC5)cc34)ccc21
6
ARG95;ILE191;PHE203;LEU245;LEU246;TYR249
9
3
4
1
1
0
1
1
1
1.04
1
1
1
8.0689
-7.873
0.6735
-3.656
43.5988
68.5338
-5.8516
0.8292
0.4388
0.1275
0.1361
0.6556
0.3032
structures/63_SAMT_II260824211321605189351a_complex.pdb