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201
610
Increased flux of microbial products suppresses immune responses.
275
Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.
506
Helminths interfere with immune system control of coinfections by microbial pathogens 16.
772
Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.
157
BLM gene encodes RecQ-class DNA helicase.
1336
UCB T cells reduce TCR diversity after transplantation.
81
Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.
429
Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.
665
KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.
416
Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.
1327
Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
400
Exposure to fine particulate air pollution is unrelated to anxiety prevalence.
114
Anthrax spores are very difficult to dispose once they are dispersed.
68
Activated Cdk5 regulates DNA damage-induced neuronal death.
680
Lack of FGF21 in mice increases life expectancy.
653
Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.
428
Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.
800
Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.
747
MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.
211
COPI coatmer is involved in viral replication.
71
Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.
274
Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.
357
During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.
246
Charcoal shows no benefit for acute paraquat poisoning.
778
Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.
253
Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.
1058
Roughly 55% of women with chronic pelvic pain have no underlying pathology.
1247
The origin of the CRF01_1b2k protein occurred between 1923 and 1956.
399
Exposure to fine particulate air pollution is relate to anxiety prevalence.
642
Insulin decreases risk of severe kidney failure.
1049
Ribosomopathies have a low degree of cell and tissue specific pathology.
692
Leuko-increased blood increases infectious complications in red blood cell transfusion.
123
Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
696
Lipopolysaccharides have an inflammation independent effect on kidney barrier function.
1288
There is a positive correlation between hip fractures and statin use.
721
Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.
606
Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.
200
CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.
568
In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.
579
In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.
1220
The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.
1282
Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.
404
Expression of oncolytic virus antigens as peptides permits additional protection against relapse.
475
Glycolysis is one of the primary glycometabolic pathways in cells.
621
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
40
A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.
727
Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.
137
Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.
1121
Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.
1103
Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.