document_id int32 185 2.68k | id stringlengths 3 4 | context stringlengths 2.88k 70.8k | question stringlengths 11 179 | is_impossible bool 1
class | answers sequence |
|---|---|---|---|---|---|
630 | 262 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the main cause of HIV-1 infection in children? | false | {
"text": [
"Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide."
],
"answer_start": [
370
]
} |
630 | 276 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What plays the crucial role in the Mother to Child Transmission of HIV-1 and what increases the risk | false | {
"text": [
"DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission."
],
"answer_start": [
2003
]
} |
630 | 278 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How many children were infected by HIV-1 in 2008-2009, worldwide? | false | {
"text": [
"more than 400,000 children were infected worldwide, mostly through MTCT and 90% of them lived in sub-Saharan Africa."
],
"answer_start": [
2291
]
} |
630 | 316 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the role of C-C Motif Chemokine Ligand 3 Like 1 (CCL3L1) in mother to child transmission of HIV-1? | false | {
"text": [
"High copy numbers of CCL3L1, a potent HIV-1 suppressive ligand for CCR5, are associated with higher chemokine production and lower risk of MTCT of HIV-1 among South African infants"
],
"answer_start": [
28143
]
} |
630 | 305 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is DC-GENR and where is it expressed? | false | {
"text": [
"Dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)) can interact with a plethora of pathogens including HIV-1 and is expressed in placental capillary endothelial cells"
],
"answer_start": [
... |
630 | 306 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How does the presence of DC-SIGNR affect the MTCT of HIV-1? | false | {
"text": [
"the presence of DC-SIGNR at the placental endothelial cell surface may protect infants from HIV-1 infection by capturing virus and promoting its degradation/presentation."
],
"answer_start": [
28910
]
} |
630 | 307 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | Why do low levels of DC-SIGNR enhance Mother to Child Transmission of HIV-1? | false | {"text":["in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on en(...TRUNCATED) |
630 | 277 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | What is the percentage of Mother to Child Transmission of HIV-1, when there is no intervention? | false | {"text":["Without specific interventions, the rate of HIV-1 mother-tochild transmission (MTCT) is ap(...TRUNCATED) |
630 | 312 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | Does C-C chemokine receptor type 5 (CCR5) affect the transmission of HIV-1? | false | {"text":["Genetic variants in CCR5 have been shown to influence vertical transmission of HIV-1. CCR5(...TRUNCATED) |
630 | 318 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | How does Mannanose Binding Lectin (MBL) affect elimination of HIV-1 pathogen? | false | {"text":["Mannose-binding lectin (MBL) is an innate immune receptor synthesised in the liver and sec(...TRUNCATED) |
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