Datasets:

electricsheepafrica
/

hepatitis-b-liver-disease

id int64	age_years int64	sex string	hbv_vaccination_history string	birth_dose_received int64	hiv_coinfection int64	on_art int64	alcohol_use string	aflatoxin_exposure int64	family_history_hcc int64	diabetes int64	hbsag_positive int64	hbeag_positive int64	hbv_dna_iu_ml int64	high_viral_load int64	alt_u_l int64	alt_elevated int64	ast_u_l int64	platelets int64	apri_score float64	fibrosis_stage string	cirrhosis int64	significant_fibrosis int64	fibroscan_kpa int64	hepatocellular_carcinoma int64	hcc_stage string	decompensated_cirrhosis int64	ascites int64	variceal_bleed int64	hepatic_encephalopathy int64	afp_level int64	ultrasound_done int64	treatment_eligible int64	on_antiviral int64	antiviral_type string	antiviral_adherence string	viral_suppression int64	outcome_1yr string	referred_tertiary int64
1	51	F	partial	0	0	0	heavy	0	0	0	1	0	-1	0	50	1	30	287	261.32	F2	0	1	-1	0	none	0	0	0	0	-1	1	1	0	none	not_applicable	0	alive	0
2	49	M	complete	0	0	0	none	0	1	0	1	0	-1	0	26	0	22	171	321.64	F1	0	0	-1	0	none	0	0	0	0	3	0	0	0	none	not_applicable	0	alive	0
3	36	F	none	0	0	0	heavy	0	0	0	1	0	-1	0	48	1	31	237	327	F3	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
4	33	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	28	0	23	271	212.18	F1	0	0	-1	0	none	0	0	0	0	3	0	0	0	none	not_applicable	0	alive	0
5	46	F	partial	0	0	0	heavy	1	1	0	1	0	-1	0	25	0	30	248	302.42	F3	0	1	-1	0	none	0	0	0	0	5	0	1	0	none	not_applicable	0	alive	0
6	30	F	complete	0	0	0	heavy	0	0	0	1	0	-1	0	15	0	24	270	222.22	F1	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
7	49	M	partial	0	0	0	moderate	1	0	1	1	0	-1	0	42	1	51	148	861.49	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
8	23	F	none	0	0	0	none	0	0	0	1	0	-1	0	5	0	34	171	497.08	F1	0	0	-1	0	none	0	0	0	0	13	0	0	0	none	not_applicable	0	alive	0
9	38	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	15	0	19	347	136.89	F3	0	1	-1	0	none	0	0	0	0	12	0	1	0	none	not_applicable	0	alive	0
10	57	M	none	0	0	0	heavy	0	0	0	1	0	-1	0	61	1	33	195	423.08	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
11	25	M	none	0	0	0	heavy	1	0	0	1	0	-1	0	34	0	27	240	281.25	F1	0	0	-1	0	none	0	0	0	0	-1	1	0	0	none	not_applicable	0	alive	0
12	53	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	28	0	45	252	446.43	F4	1	1	-1	0	none	0	0	0	0	9	0	1	1	tenofovir	moderate	0	alive	0
13	69	M	complete	1	0	0	heavy	0	0	0	1	0	-1	0	79	1	22	167	329.34	F3	0	1	-1	0	none	0	0	0	0	18	0	1	0	none	not_applicable	0	alive	0
14	33	M	partial	0	0	0	heavy	0	0	0	1	0	-1	0	27	0	27	137	492.7	F0	0	0	-1	0	none	0	0	0	0	5	0	0	0	none	not_applicable	0	alive	0
15	43	M	complete	0	1	1	none	1	0	0	1	1	-1	0	127	1	33	248	332.66	F0	0	0	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
16	48	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	27	0	5	239	52.3	F0	0	0	-1	0	none	0	0	0	0	6	0	0	0	none	not_applicable	0	alive	0
17	32	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	36	0	19	279	170.25	F0	0	0	-1	0	none	0	0	0	0	-1	1	0	0	none	not_applicable	0	alive	0
18	24	F	none	0	0	0	none	0	0	0	1	0	-1	0	21	0	14	221	158.37	F1	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
19	39	M	complete	0	0	0	moderate	0	0	0	1	1	11,285,866	1	51	1	42	284	369.72	F3	0	1	-1	0	none	0	0	0	0	3	0	1	0	none	not_applicable	0	alive	0
20	64	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	52	1	42	253	415.02	F4	1	1	-1	0	none	1	1	0	1	1	0	1	0	none	not_applicable	0	alive	0
21	69	M	complete	0	0	0	heavy	1	0	0	1	0	6,979	0	45	1	19	209	227.27	F3	0	1	-1	0	none	0	0	0	0	-1	0	1	1	tenofovir	good	1	alive	0
22	32	F	none	0	0	0	heavy	0	0	0	1	0	221	0	62	1	31	169	458.58	F1	0	0	-1	0	none	0	0	0	0	6	0	0	0	none	not_applicable	0	alive	0
23	50	F	none	0	0	0	moderate	1	1	0	1	0	-1	0	43	1	27	239	282.43	F0	0	0	-1	0	none	0	0	0	0	1	0	0	0	none	not_applicable	0	alive	0
24	56	M	none	0	0	0	none	1	0	0	1	0	-1	0	41	1	29	238	304.62	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	1	tenofovir	moderate	1	alive	0
25	40	F	partial	0	0	0	moderate	0	0	0	1	0	-1	0	39	0	51	225	566.67	F4	1	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
26	32	M	complete	1	0	0	none	1	0	0	1	0	3	0	5	0	50	273	457.88	F2	0	1	-1	0	none	0	0	0	0	5	0	1	0	none	not_applicable	0	alive	0
27	46	M	partial	0	1	1	moderate	1	0	0	1	0	-1	0	17	0	50	208	600.96	F2	0	1	-1	0	none	0	0	0	0	8	0	1	0	none	not_applicable	0	alive	0
28	32	F	none	0	0	0	none	0	0	0	1	0	9	0	18	0	33	209	394.74	F2	0	1	-1	0	none	0	0	0	0	2	0	1	0	none	not_applicable	0	alive	0
29	40	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	17	0	28	240	291.67	F2	0	1	-1	0	none	0	0	0	0	11	1	1	0	none	not_applicable	0	alive	0
30	32	F	none	0	0	0	moderate	0	0	0	1	0	-1	0	29	0	35	75	1,166.67	F4	1	1	-1	0	none	0	0	0	0	17	0	1	0	none	not_applicable	0	alive	0
31	57	M	complete	0	0	0	none	1	0	0	1	0	-1	0	5	0	37	185	500	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
32	24	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	49	1	33	183	450.82	F2	0	1	-1	0	none	0	0	0	0	9	0	1	1	tenofovir	poor	0	alive	0
33	65	F	none	0	0	0	none	1	0	0	1	1	-1	0	5	0	60	230	652.17	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
34	38	F	none	0	0	0	none	1	0	0	1	1	-1	0	67	1	5	218	57.34	F1	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
35	61	F	partial	0	0	0	none	1	0	0	1	0	-1	0	43	1	35	209	418.66	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
36	50	M	partial	0	0	0	moderate	0	0	0	1	1	-1	0	40	0	15	165	227.27	F1	0	0	-1	0	none	0	0	0	0	2	0	0	0	none	not_applicable	0	alive	0
37	49	M	none	0	0	0	none	1	0	1	1	0	-1	0	5	0	40	198	505.05	F3	0	1	-1	0	none	0	0	0	0	1	0	1	0	none	not_applicable	0	alive	0
38	27	F	none	0	0	0	moderate	1	1	0	1	1	-1	0	112	1	5	85	147.06	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	died	0
39	65	M	complete	0	0	0	heavy	0	0	0	1	0	-1	0	52	1	39	246	396.34	F1	0	0	-1	0	none	0	0	0	0	11	1	0	0	none	not_applicable	0	alive	0
40	22	M	complete	0	0	0	none	0	0	0	1	1	-1	0	82	1	10	216	115.74	F0	0	0	-1	0	none	0	0	0	0	-1	1	0	0	none	not_applicable	0	alive	0
41	63	F	none	0	1	1	none	0	0	1	1	0	-1	0	55	1	30	169	443.79	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
42	65	M	none	0	1	0	moderate	0	1	0	1	0	-1	0	40	0	12	191	157.07	F0	0	0	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
43	67	M	complete	0	0	0	moderate	1	0	0	1	0	437,751	1	71	1	24	334	179.64	F1	0	0	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
44	38	M	partial	0	0	0	none	1	0	0	1	0	-1	0	41	1	36	103	873.79	F4	1	1	-1	1	early_BCLC_A	0	0	0	0	-1	0	1	0	none	not_applicable	0	died	0
45	39	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	32	0	29	233	311.16	F4	1	1	-1	0	none	0	0	0	0	9	0	1	0	none	not_applicable	0	alive	0
46	60	F	none	0	0	0	none	1	0	0	1	0	-1	0	5	0	35	226	387.17	F3	0	1	-1	0	none	0	0	0	0	-1	1	1	0	none	not_applicable	0	alive	0
47	26	M	none	0	0	0	none	0	0	0	1	0	-1	0	45	1	50	107	1,168.22	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
48	43	M	none	0	0	0	none	1	0	0	1	0	-1	0	46	1	12	214	140.19	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
49	44	M	none	0	0	0	heavy	0	0	0	1	0	-1	0	20	0	50	190	657.89	F3	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
50	49	M	complete	0	1	1	none	1	0	0	1	0	-1	0	14	0	46	195	589.74	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
51	66	M	complete	0	0	0	moderate	0	0	0	1	0	-1	0	32	0	35	266	328.95	F2	0	1	-1	0	none	0	0	0	0	7	0	1	0	none	not_applicable	0	alive	0
52	25	M	partial	0	0	0	moderate	1	0	0	1	0	-1	0	5	0	14	158	221.52	F0	0	0	-1	0	none	0	0	0	0	11	0	0	0	none	not_applicable	0	alive	0
53	34	F	complete	0	0	0	moderate	0	0	0	1	0	-1	0	44	1	22	219	251.14	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
54	40	F	none	0	0	0	heavy	0	0	0	1	0	-1	0	30	0	31	366	211.75	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
55	37	F	complete	1	1	1	moderate	0	0	0	1	0	-1	0	30	0	6	165	90.91	F0	0	0	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
56	27	F	none	0	0	0	moderate	1	0	0	1	1	-1	0	23	0	41	230	445.65	F4	1	1	-1	0	none	0	0	0	0	10	0	1	0	none	not_applicable	0	alive	0
57	37	F	none	0	0	0	heavy	0	0	0	1	0	-1	0	29	0	12	205	146.34	F0	0	0	-1	0	none	0	0	0	0	6	0	0	0	none	not_applicable	0	alive	0
58	18	M	none	0	0	0	none	0	0	0	1	1	-1	0	5	0	26	178	365.17	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
59	40	M	none	0	0	0	none	0	0	0	1	1	-1	0	55	1	32	277	288.81	F0	0	0	-1	0	none	0	0	0	0	8	0	0	0	none	not_applicable	0	alive	0
60	70	M	none	0	0	0	none	0	0	0	1	0	-1	0	26	0	24	151	397.35	F2	0	1	-1	0	none	0	0	0	0	7	0	1	0	none	not_applicable	0	alive	0
61	26	M	partial	0	0	0	none	1	0	0	1	0	-1	0	47	1	27	311	217.04	F1	0	0	-1	0	none	0	0	0	0	17	0	0	0	none	not_applicable	0	alive	0
62	50	M	none	0	0	0	none	1	0	0	1	0	-1	0	17	0	64	237	675.11	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	1	tenofovir	good	1	alive	0
63	74	F	none	0	0	0	none	0	0	0	1	0	-1	0	24	0	13	148	219.59	F2	0	1	-1	0	none	0	0	0	0	9	0	1	1	tenofovir	good	1	alive	0
64	42	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	65	1	18	238	189.08	F1	0	0	-1	0	none	0	0	0	0	7	1	0	0	none	not_applicable	0	alive	0
65	54	M	partial	0	0	0	none	0	0	0	1	0	472,081	1	27	0	35	182	480.77	F0	0	0	-1	1	advanced_BCLC_C	0	0	0	0	-1	1	0	0	none	not_applicable	0	died	0
66	38	M	none	0	0	0	none	0	0	0	1	0	-1	0	26	0	24	92	652.17	F1	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
67	44	M	none	0	0	0	none	0	0	0	1	0	-1	0	28	0	12	268	111.94	F3	0	1	-1	0	none	0	0	0	0	17	1	1	0	none	not_applicable	0	alive	0
68	53	M	partial	0	0	0	moderate	1	0	0	1	0	-1	0	49	1	5	155	80.65	F4	1	1	-1	0	none	0	0	0	0	-1	1	1	0	none	not_applicable	0	alive	0
69	48	M	none	0	0	0	heavy	0	1	0	1	0	-1	0	29	0	38	142	669.01	F0	0	0	-1	1	terminal_BCLC_D	0	0	0	0	196	0	0	0	none	not_applicable	0	died	0
70	39	M	complete	0	0	0	none	0	1	0	1	0	-1	0	5	0	42	244	430.33	F4	1	1	-1	1	terminal_BCLC_D	0	0	0	0	-1	0	1	0	none	not_applicable	0	died	0
71	43	M	none	0	0	0	none	0	0	0	1	0	15,606	0	5	0	57	256	556.64	F1	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
72	28	M	none	0	0	0	heavy	0	0	0	1	0	-1	0	79	1	6	295	50.85	F1	0	0	-1	0	none	0	0	0	0	12	0	0	0	none	not_applicable	0	alive	0
73	46	M	none	0	0	0	moderate	0	0	0	1	1	-1	0	40	0	33	214	385.51	F1	0	0	-1	0	none	0	0	0	0	13	0	0	0	none	not_applicable	0	alive	0
74	40	M	partial	0	1	0	none	0	0	0	1	1	-1	0	32	0	52	213	610.33	F4	1	1	-1	0	none	1	1	0	0	10	0	1	0	none	not_applicable	0	alive	0
75	30	M	none	0	0	0	moderate	0	0	0	1	1	-1	0	97	1	38	226	420.35	F2	0	1	-1	0	none	0	0	0	0	12	0	1	1	tenofovir	good	1	alive	0
76	52	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	41	1	26	249	261.04	F1	0	0	-1	0	none	0	0	0	0	8	1	0	0	none	not_applicable	0	alive	0
77	33	M	complete	0	0	0	moderate	0	0	0	1	0	-1	0	31	0	23	284	202.46	F0	0	0	-1	1	advanced_BCLC_C	0	0	0	0	248	0	0	0	none	not_applicable	0	died	0
78	28	M	complete	0	0	0	heavy	0	0	0	1	0	-1	0	62	1	26	113	575.22	F2	0	1	-1	0	none	0	0	0	0	1	1	1	0	none	not_applicable	0	alive	0
79	55	M	none	0	0	0	none	0	0	0	1	0	-1	0	22	0	12	229	131	F2	0	1	-1	0	none	0	0	0	0	6	0	1	0	none	not_applicable	0	alive	0
80	31	M	partial	0	0	0	none	1	0	0	1	0	2,093	0	5	0	5	276	45.29	F0	0	0	-1	0	none	0	0	0	0	1	0	0	0	none	not_applicable	0	alive	0
81	58	M	complete	0	0	0	moderate	1	0	0	1	0	-1	0	45	1	32	206	388.35	F4	1	1	-1	1	intermediate_BCLC_B	1	1	0	0	2,490	0	1	1	tenofovir	moderate	0	died	0
82	63	F	none	0	1	0	none	0	0	0	1	0	-1	0	5	0	44	220	500	F2	0	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
83	28	M	partial	0	0	0	moderate	0	0	0	1	0	-1	0	30	0	6	243	61.73	F4	1	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
84	65	M	none	0	0	0	none	0	0	0	1	0	-1	0	30	0	5	279	44.8	F3	0	1	-1	0	none	0	0	0	0	1	0	1	0	none	not_applicable	0	alive	0
85	21	F	none	0	0	0	heavy	1	0	0	1	0	-1	0	24	0	11	244	112.7	F3	0	1	-1	0	none	0	0	0	0	9	0	1	0	none	not_applicable	0	alive	0
86	48	M	none	0	0	0	moderate	1	0	0	1	0	-1	0	32	0	14	227	154.19	F4	1	1	-1	0	none	1	1	1	1	17	1	1	1	entecavir	moderate	0	alive	0
87	49	F	none	0	0	0	none	1	0	0	1	1	-1	0	106	1	18	185	243.24	F2	0	1	-1	0	none	0	0	0	0	4	0	1	0	none	not_applicable	0	alive	0
88	30	F	partial	0	0	0	moderate	1	0	0	1	0	-1	0	13	0	14	211	165.88	F0	0	0	-1	0	none	0	0	0	0	22	0	0	0	none	not_applicable	0	alive	0
89	35	M	none	0	0	0	heavy	0	0	0	1	0	-1	0	51	1	31	73	1,061.64	F4	1	1	-1	0	none	0	0	0	0	-1	0	1	0	none	not_applicable	0	alive	0
90	23	M	none	0	0	0	moderate	1	0	0	1	1	-1	0	26	0	36	201	447.76	F1	0	0	-1	0	none	0	0	0	0	10	0	0	0	none	not_applicable	0	alive	0
91	62	M	none	0	0	0	none	0	0	0	1	0	-1	0	5	0	41	293	349.83	F2	0	1	-1	0	none	0	0	0	0	12	0	1	0	none	not_applicable	0	alive	0
92	54	M	none	0	0	0	moderate	0	0	0	1	0	-1	0	23	0	30	272	275.74	F4	1	1	-1	0	none	1	0	0	1	4	0	1	0	none	not_applicable	0	died	1
93	43	F	none	0	0	0	none	0	1	0	1	0	1,536	0	48	1	24	234	256.41	F0	0	0	-1	0	none	0	0	0	0	-1	0	0	0	none	not_applicable	0	alive	0
94	35	M	none	0	0	0	none	1	0	0	1	0	3	0	40	0	14	231	151.52	F3	0	1	-1	0	none	0	0	0	0	4	0	1	0	none	not_applicable	0	alive	0
95	30	M	none	0	0	0	heavy	1	0	0	1	1	-1	0	85	1	22	246	223.58	F4	1	1	-1	0	none	1	0	0	0	13	0	1	0	none	not_applicable	0	died	0
96	64	M	none	0	0	0	heavy	0	0	0	1	0	-1	0	17	0	49	138	887.68	F4	1	1	-1	1	terminal_BCLC_D	1	1	0	0	-1	0	1	0	none	not_applicable	0	died	0
97	28	M	complete	0	0	0	heavy	0	0	0	1	0	-1	0	29	0	21	229	229.26	F2	0	1	-1	0	none	0	0	0	0	4	1	1	0	none	not_applicable	0	alive	0
98	35	M	none	0	0	0	none	0	0	0	1	0	-1	0	39	0	53	249	532.13	F1	0	0	-1	0	none	0	0	0	0	6	0	0	0	none	not_applicable	0	alive	0
99	42	M	none	0	0	0	heavy	1	0	0	1	0	-1	0	33	0	22	352	156.25	F0	0	0	-1	0	none	0	0	0	0	-1	1	0	0	none	not_applicable	0	alive	0
100	61	M	none	0	0	0	none	0	0	0	1	1	767,941,624	1	38	0	20	254	196.85	F4	1	1	-1	0	none	0	0	0	0	7	0	1	0	none	not_applicable	0	alive	0

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Hepatitis B & Liver Disease Dataset

Abstract

This dataset provides 30,000 simulated records (10,000 per scenario) of adults with chronic hepatitis B across sub-Saharan African settings. Each record contains 50+ variables including HBV markers (HBsAg, HBeAg, HBV DNA, ALT), liver fibrosis staging (Metavir, APRI, FibroScan), complications (HCC with BCLC staging, decompensated cirrhosis, variceal bleeding), antiviral treatment, and 1-year outcomes. Three settings: hepatology referral centre, district hospital, and community screening programme.

1. Introduction

Sub-Saharan Africa has 60 million people chronically infected with HBV, with HBsAg carrier rates of 5-20% (Spearman et al., 2021). WHO estimates 254 million living with chronic HBV globally, causing 1.1 million deaths in 2022 from cirrhosis and HCC (WHO 2024). HCC incidence in SSA is projected to double by 2040 due to the large chronic HBV reservoir. Only ~2% of eligible patients receive antiviral treatment in SSA (Shimakawa et al., 2016). The PROLIFICA study in Gambia found HBeAg positivity of 18%, significant fibrosis in 8.4%, and treatment eligibility of 12% among HBsAg+ adults (Lemoine et al., 2016).

This dataset is entirely simulated. It must not be used for clinical decision-making.

2. Methodology

2.1 Parameterization

Parameter	Value	Source
Chronic HBV in SSA	60 million	Spearman et al., 2021
HBsAg carrier rate (SSA)	5-20%	Multiple sources
HBeAg+ among HBsAg+	18%	PROLIFICA, Lemoine et al., 2016
Significant fibrosis	8.4%	PROLIFICA 2016
Treatment eligibility	12%	PROLIFICA 2016
On treatment (SSA)	~2% of eligible	Shimakawa et al., 2016
HCC 5-year survival (SSA)	<10%	Maponga et al., 2022
Global HBV deaths	1.1M (2022)	WHO 2024

2.2 Scenario Design

Scenario	Facility	FibroScan	HBV DNA	On Treatment	HCC Mortality
Hepatology centre	Referral centre	Yes	Yes	27%	70%
District hospital	Basic ALT/US	No	No	8%	85%
Community screening	HBsAg rapid test	No	No	1%	95%

3. Schema

Column	Type	Description
id	int	Unique identifier
age_years	int	Patient age
sex	categorical	M / F
hbv_vaccination_history	categorical	none / partial / complete
birth_dose_received	binary	HBV birth dose received
hiv_coinfection	binary	HIV co-infection
on_art	binary	On ART (if HIV+)
alcohol_use	categorical	none / moderate / heavy
aflatoxin_exposure	binary	Aflatoxin exposure
family_history_hcc	binary	Family history HCC
diabetes	binary	Diabetes
hbsag_positive	binary	HBsAg positive (all)
hbeag_positive	binary	HBeAg positive
hbv_dna_iu_ml	int	HBV DNA (-1 if not done)
high_viral_load	binary	HBV DNA >20,000 IU/mL
alt_u_l	int	ALT level
alt_elevated	binary	ALT >40 U/L
ast_u_l	int	AST level
platelets	int	Platelet count
apri_score	float	APRI score
fibrosis_stage	categorical	F0 / F1 / F2 / F3 / F4
cirrhosis	binary	F4 fibrosis
significant_fibrosis	binary	F2+
fibroscan_done	binary	FibroScan performed
fibroscan_kpa	float	FibroScan value (kPa)
hepatocellular_carcinoma	binary	HCC
hcc_stage	categorical	early_BCLC_A / intermediate_B / advanced_C / terminal_D
decompensated_cirrhosis	binary	Decompensated cirrhosis
ascites	binary	Ascites
variceal_bleed	binary	Variceal bleeding
hepatic_encephalopathy	binary	Hepatic encephalopathy
afp_level	int	AFP level (-1 if not done)
ultrasound_done	binary	Ultrasound screening
treatment_eligible	binary	Eligible for antiviral
on_antiviral	binary	On antiviral treatment
antiviral_type	categorical	tenofovir / entecavir / tenofovir_art / none
antiviral_adherence	categorical	good / moderate / poor / not_applicable
viral_suppression	binary	Viral suppression achieved
outcome_1yr	categorical	alive / died
referred_tertiary	binary	Referred to tertiary

4. Validation

Validation Report

Key validation checks:

HBeAg+ ~18%: Consistent with PROLIFICA ✓
Treatment gap: 27% → 8% → 1%, reflecting SSA reality ✓
HCC ~6-7%: Higher than population (clinic-based) ✓
Late HCC presentation: 65% advanced/terminal BCLC stage ✓
Risk factor enrichment: Cirrhosis, male, age >50, aflatoxin in HCC cases ✓
Fibrosis distribution: F0-F1 dominant, F4 ~13% ✓

5. Usage

from datasets import load_dataset
dataset = load_dataset("electricsheepafrica/hepatitis-b-liver-disease", "district_hospital")
df = dataset["train"].to_pandas()

python generate_dataset.py --all-scenarios --n 10000 --seed 42

6. Limitations

Simulated: Not derived from real hepatology registries.
No imaging: Ultrasound/CT findings are binary, not imaged.
No HBV genotype: SSA genotypes (A, D, E) not modelled.
Simplified HCC staging: BCLC categorical, no tumour size/number.
No longitudinal: Single timepoint, no treatment response curves.

7. References

WHO (2024). Updated guidelines for chronic HBV. Hepatitis B fact sheet.
Spearman CW, et al. (2021). HBV in SSA. World J Gastroenterol, 27(30):5003.
WHO Africa/BMC Glob Pub Health (2023). 82M PLWHB in Africa.
Maponga TG, et al. (2022). HCC in SSA. Dig Dis Sci, 67(10):4648.
Lemoine M, et al. (2016). PROLIFICA Gambia. Lancet Gastro Hepatol, 1(2):97.
Shimakawa Y, et al. (2016). HBV elimination framework. J Hepatol, 65(1 Suppl):S209.
Stockdale AJ, et al. (2020). HBV SSA meta-analysis. J Hepatol, 73(3):533.
WHO (2024). Hepatitis B fact sheet.

Citation

@dataset{esa_hbv_2025,
  title={Hepatitis B and Liver Disease Dataset},
  author={Electric Sheep Africa},
  year={2025},
  publisher={Hugging Face},
  url={https://huggingface.co/datasets/electricsheepafrica/hepatitis-b-liver-disease}
}

License

CC-BY-4.0

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