id stringlengths 38 67 | label stringlengths 2 29 | sentence stringlengths 7 11.7k | has_group_left bool 2
classes | note_id stringlengths 6 10 | dedup_val stringlengths 11 40 | __index_level_0__ int64 0 824k |
|---|---|---|---|---|---|---|
note_34_span_Male_100000_150000_mid_mesh | healthy women undergoing | STUDY QUESTION: Can of Clinical Genetics, Maastricht University Medical Centre, Maastricht kisspeptin and its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved?SUMMARY ANSWER: Kisspeptin analogue-mediated cell motility in human decidual stromal cells ... | true | note_34 | note_34_ healthy women undergoing | 112 |
note_34_span_Mice_100000_150000_mid_mesh | (MMPs) | STUDY QUESTION: Can of Clinical Genetics, Maastricht University Medical Centre, Maastricht kisspeptin and its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved?SUMMARY ANSWER: Kisspeptin analogue-mediated cell motility in human decidual stromal cells ... | true | note_34 | note_34_ (MMPs) | 113 |
note_35_span_Animals_100000_150000_mid_mesh | KNOWN ALREADY: | STUDY QUESTION: Do clinical characteristics of recurrent miscarriage couples with a chromosomal abnormality and who opt for PGD differ from couples that decline PGD after extensive genetic counselling?SUMMARY ANSWER: No differences in clinical characteristics are identified between recurrent miscarriage couples carryin... | false | note_35 | note_35_ KNOWN ALREADY: | 114 |
note_35_span_Animals_100000_150000_mid_mesh | these personal motives that | STUDY QUESTION: Do clinical characteristics of recurrent miscarriage couples with a chromosomal abnormality and who opt for PGD differ from couples that decline PGD after extensive genetic counselling?SUMMARY ANSWER: No differences in clinical characteristics are identified between recurrent miscarriage couples carryin... | true | note_35 | note_35_ these personal motives that | 115 |
note_35_span_Disease Models, Animal_100000_150000_mid_mesh | for PGD | STUDY QUESTION: Do clinical characteristics of recurrent miscarriage couples with a chromosomal abnormality and who opt<think> differ from couples that decline PGD after extensive genetic counselling?SUMMARY ANSWER: No differences in clinical characteristics are identified between recurrent miscarriage couples carryin... | true | note_35 | note_35_ for PGD | 116 |
note_35_span_Disease Models, Animal_100000_150000_mid_mesh | couples.STUDY DESIGN, SIZE, | STUDY QUESTION: Do clinical characteristics of recurrent miscarriage couples with a chromosomal abnormality and who opt for PGD differ from couples that decline PGD after extensive genetic counselling?SUMMARY ANSWER: No differences in clinical characteristics are identified between recurrent miscarriage couples carryin... | true | note_35 | note_35_ couples.STUDY DESIGN, SIZE, | 118 |
note_36_span_Cell Line, Tumor_100000_150000_mid_mesh | fewer trophoblast | Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function. Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor ... | false | note_36 | note_36_ fewer trophoblast | 119 |
note_36_span_Aged_100000_150000_mid_mesh | AM). However, we previously | Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function. Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor ... | true | note_36 | note_36_ AM). However, we previously | 120 |
note_37_span_Animals_100000_150000_mid_mesh | of metabolic networks are | In this work maximum entropy distributions in the space of steady states<think> considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization) and its fluctuati... | false | note_37 | note_37_ of metabolic networks are | 121 |
note_37_span_Animals_100000_150000_mid_mesh | E. coli cultures in | In this work maximum entropy distributions in the space of steady states of metabolic networks are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization)... | true | note_37 | note_37_ E. coli cultures in | 122 |
note_37_span_Signal Transduction_100000_150000_mid_mesh | of metabolic networks | In this work maximum entropy distributions in the space of steady states<think> are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization) and its fluct... | false | note_37 | note_37_ of metabolic networks | 123 |
note_37_span_Signal Transduction_100000_150000_mid_mesh | with metabolic fluxes, | In this work maximum entropy distributions in the space of steady states of metabolic networks are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization)... | true | note_37 | note_37_ with metabolic fluxes, | 124 |
note_37_span_Signal Transduction_100000_150000_mid_mesh | E. coli cultures | In this work maximum entropy distributions in the space of steady states of metabolic networks are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization)... | true | note_37 | note_37_ E. coli cultures | 125 |
note_38_span_Animals_100000_150000_mid_mesh | mesothelial pericardial | Pericardial cysts are rare and generally benign intrathoracic lesions, most frequently located in the cardiophrenic angles, but other locations have been described. We present a case of a pericardial cyst in a previously undescribed site. Our patient presented with a cyst in the interventricular septum which was discov... | false | note_38 | note_38_ mesothelial pericardial | 126 |
note_38_span_Male_100000_150000_mid_mesh | site. Our patient presented | Pericardial cysts are rare and generally benign intrathoracic lesions, most frequently located in the cardiophrenic angles, but other locations have been described. We present a case of a pericardial cyst in a previously undescribed<think> with a cyst in the interventricular septum which was discovered as an incidenta... | false | note_38 | note_38_ site. Our patient presented | 127 |
note_39_span_Time Factors_100000_150000_mid_mesh | and time dependent manner. | To understand the adverse effects of cholesterol crystals on vascular homeostasis, we have studied their effects on endothelial barrier function. Cholesterol crystals increased endothelial barrier permeability in a dose<think> In addition, cholesterol crystals induced tyrosine phosphorylation of VE-cadherin and �-cate... | false | note_39 | note_39_ and time dependent manner. | 128 |
note_40_span_Cell Line, Tumor_100000_150000_mid_mesh | injury, which is | INTRODUCTION: Documentation and evaluation of dental injuries in forensic medicine are rather problematic. It needs a professional work up why dental injuries are out of focus, and how the diagnosis, pattern and treatment are influenced by novel approaches of dentistry.AIM: The aims of the authors were to characterize ... | false | note_40 | note_40_ injury, which is | 129 |
note_41_span_Signal Transduction_100000_150000_mid_mesh | soil-transmitted | BACKGROUND: Over 20 million preschool-age children (PSAC) in Nigeria require periodic chemotherapy (PC) for<think> helminth (STH) infections. Persistently low coverage for this age group threatens the World Health Organization (WHO) 2030 target for eliminating STH infections. Current strategies for targeting PSAC have... | false | note_41 | note_41_ soil-transmitted | 130 |
note_41_span_Time Factors_100000_150000_mid_mesh | 2030 | BACKGROUND: Over 20 million preschool-age children (PSAC) in Nigeria require periodic chemotherapy (PC) for soil-transmitted helminth (STH) infections. Persistently low coverage for this age group threatens the World Health Organization (WHO)<think> target for eliminating STH infections. Current strategies for targeti... | false | note_41 | note_41_ 2030 | 131 |
note_42_span_Male_100000_150000_mid_mesh | for sex and | BACKGROUND: Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging.METHODS: Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcep... | false | note_42 | note_42_ for sex and | 132 |
note_42_span_Aged_100000_150000_mid_mesh | maternal Zika virus | BACKGROUND: Congenital microcephaly has been linked to<think> infection. However, ascertaining infants diagnosed with microcephaly can be challenging.METHODS: Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,... | false | note_42 | note_42_ maternal Zika virus | 133 |
note_43_span_Signal Transduction_100000_150000_mid_mesh | Adsorption | <think> of organic pollutants onto microplastics has been reported in prior studies, indicating the potential of these particles to serve as vectors of pollutants. Most prior investigations, however, have been conducted in laboratories under conditions with relatively little environmental relevance. Here we report the ... | false | note_43 | note_43_Adsorption | 134 |
note_43_span_Signal Transduction_100000_150000_mid_mesh | type. Rapid biofouling, | Adsorption of organic pollutants onto microplastics has been reported in prior studies, indicating the potential of these particles to serve as vectors of pollutants. Most prior investigations, however, have been conducted in laboratories under conditions with relatively little environmental relevance. Here we report t... | true | note_43 | note_43_ type. Rapid biofouling, | 135 |
note_43_span_Disease Models, Animal_100000_150000_mid_mesh | of pharmaceuticals | Adsorption of organic pollutants onto microplastics has been reported in prior studies, indicating the potential of these particles to serve as vectors of pollutants. Most prior investigations, however, have been conducted in laboratories under conditions with relatively little environmental relevance. Here we report t... | false | note_43 | note_43_ of pharmaceuticals | 136 |
note_44_span_Prognosis_100000_150000_mid_mesh | be worsening by | INTRODUCTION: The health of the British population has been shown to<think> self-reported health and improving by self-reported limiting illness for those born before and after 1945. Little is known about the inequality in health difference across British birth cohorts by income.METHODS: Repeated cross-sections from t... | false | note_44 | note_44_ be worsening by | 137 |
note_44_span_Surveys and Questionnaires_100000_150000_mid_mesh | Household Survey, | INTRODUCTION: The health of the British population has been shown to be worsening by self-reported health and improving by self-reported limiting illness for those born before and after 1945. Little is known about the inequality in health difference across British birth cohorts by income.METHODS: Repeated cross-section... | false | note_44 | note_44_ Household Survey, | 138 |
note_45_span_Surveys and Questionnaires_100000_150000_mid_mesh | the prevalence rates | BACKGROUND: Preservatives are added to cosmetics and other consumer products to prevent microbial growth and product degradation. Many cosmetic preservatives are skin sensitizers and frequent causes of contact dermatitis. The use of preservatives may vary by country and/or region, according to legislation, and may be r... | false | note_45 | note_45_ the prevalence rates | 139 |
note_45_span_Surveys and Questionnaires_100000_150000_mid_mesh | products.CONCLUSION: | BACKGROUND: Preservatives are added to cosmetics and other consumer products to prevent microbial growth and product degradation. Many cosmetic preservatives are skin sensitizers and frequent causes of contact dermatitis. The use of preservatives may vary by country and/or region, according to legislation, and may be r... | true | note_45 | note_45_ products.CONCLUSION: | 140 |
note_46_span_Time Factors_100000_150000_mid_mesh | rats. We failed | Rats are highly social creatures that produce ultrasonic vocalizations (USVs) during social interactions. Brattleboro rats, a Long-Evans derived rat that lacks vasopressin (AVP) due to a mutation in the Avp gene, exhibit atypical social behavior, including fewer USVs with altered spectrotemporal characteristics during ... | true | note_46 | note_46_ rats. We failed | 142 |
note_46_span_Disease Models, Animal_100000_150000_mid_mesh | Brattleboro rats, | Rats are highly social creatures that produce ultrasonic vocalizations (USVs) during social interactions.<think> a Long-Evans derived rat that lacks vasopressin (AVP) due to a mutation in the Avp gene, exhibit atypical social behavior, including fewer USVs with altered spectrotemporal characteristics during social int... | false | note_46 | note_46_ Brattleboro rats, | 143 |
note_46_span_Disease Models, Animal_100000_150000_mid_mesh | these rats. | Rats are highly social creatures that produce ultrasonic vocalizations (USVs) during social interactions. Brattleboro rats, a Long-Evans derived rat that lacks vasopressin (AVP) due to a mutation in the Avp gene, exhibit atypical social behavior, including fewer USVs with altered spectrotemporal characteristics during ... | true | note_46 | note_46_ these rats. | 144 |
note_46_span_Disease Models, Animal_100000_150000_mid_mesh | in rat audiograms | Rats are highly social creatures that produce ultrasonic vocalizations (USVs) during social interactions. Brattleboro rats, a Long-Evans derived rat that lacks vasopressin (AVP) due to a mutation in the Avp gene, exhibit atypical social behavior, including fewer USVs with altered spectrotemporal characteristics during ... | true | note_46 | note_46_ in rat audiograms | 145 |
note_47_span_Pregnancy_100000_150000_mid_mesh | of cannabis policy | OBJECTIVES: To examine the effect<think> liberalisation (decriminalisation and legalisation) levels of use in adolescents and young adults.DESIGN: Systematic review and meta-analysis.INCLUSION CRITERIA: Included studies were conducted among individuals younger than 25 years and quantitatively assessing consequences of... | false | note_47 | note_47_ of cannabis policy | 146 |
note_49_span_Cell Line, Tumor_100000_150000_mid_mesh | were synthesized and | Graphene oxide wrapped silica nanocomposites<think> selected as solid phase extraction adsorbents for high performance liquid chromatography analysis of aflatoxins. The major parameters affecting extraction efficiency were optimized, including the amount of adsorbents, extraction time and desorption conditions. The li... | false | note_49 | note_49_ were synthesized and | 147 |
note_50_span_Time Factors_100000_150000_mid_mesh | for 72�h | Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), one of the most universally used organophosphate flame retardants (OPFRs), is an environmental pollutant. However, limited information is available regarding its toxicity and environmental health risk. In the present study, PC12�cells provided a useful model for the eval... | false | note_50 | note_50_ for 72�h | 148 |
note_50_span_Male_100000_150000_mid_mesh | flame retardants | Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), one of the most universally used organophosphate<think> (OPFRs), is an environmental pollutant. However, limited information is available regarding its toxicity and environmental health risk. In the present study, PC12�cells provided a useful model for the evaluation of... | false | note_50 | note_50_ flame retardants | 149 |
note_50_span_Male_100000_150000_mid_mesh | present study, PC12�cells | Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), one of the most universally used organophosphate flame retardants (OPFRs), is an environmental pollutant. However, limited information is available regarding its toxicity and environmental health risk. In the<think> provided a useful model for the evaluation of the toxi... | true | note_50 | note_50_ present study, PC12�cells | 150 |
note_52_span_Adolescent_100000_150000_mid_mesh | in children with | AIM: To describe gross motor function<think> bilateral lower limb (BLL) spasticity due to human immunodeficiency virus encephalopathy (HIVE), and to investigate the association between age, CD4 percentage, and viral load at initiation of antiretroviral therapy (ART) and current gross motor function.METHOD: Thirty ambu... | false | note_52 | note_52_ in children with | 151 |
note_52_span_Cell Line, Tumor_100000_150000_mid_mesh | AIM: To | <think> describe gross motor function in children with bilateral lower limb (BLL) spasticity due to human immunodeficiency virus encephalopathy (HIVE), and to investigate the association between age, CD4 percentage, and viral load at initiation of antiretroviral therapy (ART) and current gross motor function.METHOD: Th... | false | note_52 | note_52_AIM: To | 152 |
note_52_span_Cell Line, Tumor_100000_150000_mid_mesh | to human immunodeficiency | AIM: To describe gross motor function in children with bilateral lower limb (BLL) spasticity due<think> virus encephalopathy (HIVE), and to investigate the association between age, CD4 percentage, and viral load at initiation of antiretroviral therapy (ART) and current gross motor function.METHOD: Thirty ambulant chil... | true | note_52 | note_52_ to human immunodeficiency | 153 |
note_53_span_Adolescent_100000_150000_mid_mesh | slightly older (65 vs. | BACKGROUND: Minimally invasive pancreaticoduodenectomy (PD) remains an uncommon procedure, and the safety and efficacy remain uncertain beyond single institution case series. The aim of this study is to compare outcomes and costs between laparoscopic (LPD) and open PD (OPD) using a large population-based database.METHO... | false | note_53 | note_53_ slightly older (65 vs. | 154 |
note_53_span_Mice_100000_150000_mid_mesh | LPD morbidity | BACKGROUND: Minimally invasive pancreaticoduodenectomy (PD) remains an uncommon procedure, and the safety and efficacy remain uncertain beyond single institution case series. The aim of this study is to compare outcomes and costs between laparoscopic (LPD) and open PD (OPD) using a large population-based database.METHO... | true | note_53 | note_53_ LPD morbidity | 155 |
note_54_span_Mice_100000_150000_mid_mesh | and molecular profiling | Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that leads to demyelinated lesions in the grey and white matter. Inflammatory, active demyelinating white matter lesions predominate in the relapsing-remitting disease stages, whereas in the progressive stage the so-called slowly expanding... | false | note_54 | note_54_ and molecular profiling | 156 |
note_54_span_Male_100000_150000_mid_mesh | eight males), | Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that leads to demyelinated lesions in the grey and white matter. Inflammatory, active demyelinating white matter lesions predominate in the relapsing-remitting disease stages, whereas in the progressive stage the so-called slowly expanding... | false | note_54 | note_54_ eight males), | 157 |
note_55_span_Adolescent_100000_150000_mid_mesh | in elderly patients | BACKGROUNDS: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common<think> with parkinsonism. However, no systematic study has been ... | false | note_55 | note_55_ in elderly patients | 158 |
note_56_span_Pregnancy_100000_150000_mid_mesh | of supplementation, | BACKGROUND: We performed a randomized controlled chemoprevention trial of oral leukoplakia by administrating a low dose of beta-carotene and vitamin C supplements. 17% of subjects in the experimental arm (4/23) demonstrated clinical remission (complete or partial response) at completion of the trial. The objective of t... | false | note_56 | note_56_ of supplementation, | 159 |
note_56_span_Pregnancy_100000_150000_mid_mesh | to clinical response | BACKGROUND: We performed a randomized controlled chemoprevention trial of oral leukoplakia by administrating a low dose of beta-carotene and vitamin C supplements. 17% of subjects in the experimental arm (4/23) demonstrated clinical remission (complete or partial response) at completion of the trial. The objective of t... | true | note_56 | note_56_ to clinical response | 160 |
note_56_span_Adolescent_100000_150000_mid_mesh | biomarkers that | BACKGROUND: We performed a randomized controlled chemoprevention trial of oral leukoplakia by administrating a low dose of beta-carotene and vitamin C supplements. 17% of subjects in the experimental arm (4/23) demonstrated clinical remission (complete or partial response) at completion of the trial. The objective of t... | true | note_56 | note_56_ biomarkers that | 162 |
note_57_span_Disease Models, Animal_100000_150000_mid_mesh | this research, | The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (<1%). However, new infections continue to emerge. In<think> 3796 HIV-1 pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003-2015 were analysed using... | false | note_57 | note_57_ this research, | 163 |
note_57_span_Disease Models, Animal_100000_150000_mid_mesh | controlling HIV-1 infections | The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (<1%). However, new infections continue to emerge. In this research, 3796 HIV-1 pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003-2015 were analyse... | true | note_57 | note_57_ controlling HIV-1 infections | 164 |
note_57_span_Male_100000_150000_mid_mesh | being female (adjusted | The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (<1%). However, new infections continue to emerge. In this research, 3796 HIV-1 pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003-2015 were analyse... | false | note_57 | note_57_ being female (adjusted | 165 |
note_58_span_Prognosis_100000_150000_mid_mesh | nongenomic action. | Distinct from ovarian estradiol, the steroid hormone 17?-estradiol (E2) is produced in the brain and is involved in numerous functions, particularly acting as a neurosteroid. However, the physiological role of E2 and the mechanism of its effects are not well known. In hippocampal slices, 17?-estradiol has been found to... | false | note_58 | note_58_ nongenomic action. | 166 |
note_58_span_Surveys and Questionnaires_100000_150000_mid_mesh | E2, we examined the | Distinct from ovarian estradiol, the steroid hormone 17?-estradiol (E2) is produced in the brain and is involved in numerous functions, particularly acting as a neurosteroid. However, the physiological role of E2 and the mechanism of its effects are not well known. In hippocampal slices, 17?-estradiol has been found to... | false | note_58 | note_58_ E2, we examined the | 167 |
note_58_span_Surveys and Questionnaires_100000_150000_mid_mesh | cells. These data indicate | Distinct from ovarian estradiol, the steroid hormone 17?-estradiol (E2) is produced in the brain and is involved in numerous functions, particularly acting as a neurosteroid. However, the physiological role of E2 and the mechanism of its effects are not well known. In hippocampal slices, 17?-estradiol has been found to... | true | note_58 | note_58_ cells. These data indicate | 168 |
note_58_span_Surveys and Questionnaires_100000_150000_mid_mesh | signaling affect synaptic | Distinct from ovarian estradiol, the steroid hormone 17?-estradiol (E2) is produced in the brain and is involved in numerous functions, particularly acting as a neurosteroid. However, the physiological role of E2 and the mechanism of its effects are not well known. In hippocampal slices, 17?-estradiol has been found to... | true | note_58 | note_58_ signaling affect synaptic | 169 |
note_59_span_Signal Transduction_100000_150000_mid_mesh | (SGF | We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry method was used to produce the amorphous salt of CFZ with poly(acrylic acid) (PAA) at 75 wt % drug loading. The synthesis was perf... | false | note_59 | note_59_ (SGF | 170 |
note_59_span_Pregnancy_100000_150000_mid_mesh | amorphous drugs with | We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry method was used to produce the amorphous salt of CFZ with poly(acrylic acid) (PAA) at 75 wt % drug loading. The synthesis was perf... | false | note_59 | note_59_ amorphous drugs with | 171 |
note_61_span_Treatment Outcome_100000_150000_mid_mesh | cancer treatment is | BACKGROUND: It is well established that mutations in the BRCA1 gene are a major risk factor for breast cancer. Induction of cancer cell death and inhibition of survival are the main principles of cancer therapy. In this context, autophagy may have dual roles in cancer, acting on the one hand as a tumor suppressor and o... | false | note_61 | note_61_ cancer treatment is | 172 |
note_61_span_Surveys and Questionnaires_100000_150000_mid_mesh | in Egypt. Secondly | BACKGROUND: It is well established that mutations in the BRCA1 gene are a major risk factor for breast cancer. Induction of cancer cell death and inhibition of survival are the main principles of cancer therapy. In this context, autophagy may have dual roles in cancer, acting on the one hand as a tumor suppressor and o... | false | note_61 | note_61_ in Egypt. Secondly | 173 |
note_62_span_Animals_100000_150000_mid_mesh | Mice deficient | We describe a protective early acquired immune response to pneumococcal pneumonia that is mediated by a subset of B1a cells.<think> in B1 cells (xid), or activation-induced cytidine deaminase (AID(-/-) ), or invariant natural killer T (iNKT) cells (J�18(-/-) ), or interleukin-13 (IL-13(-/-) ) had impaired early cleara... | false | note_62 | note_62_ Mice deficient | 174 |
note_62_span_Animals_100000_150000_mid_mesh | the antibody affinity | We describe a protective early acquired immune response to pneumococcal pneumonia that is mediated by a subset of B1a cells. Mice deficient in B1 cells (xid), or activation-induced cytidine deaminase (AID(-/-) ), or invariant natural killer T (iNKT) cells (J�18(-/-) ), or interleukin-13 (IL-13(-/-) ) had impaired early... | true | note_62 | note_62_ the antibody affinity | 175 |
note_62_span_Pregnancy_100000_150000_mid_mesh | the pneumonia model, | We describe a protective early acquired immune response to pneumococcal pneumonia that is mediated by a subset of B1a cells. Mice deficient in B1 cells (xid), or activation-induced cytidine deaminase (AID(-/-) ), or invariant natural killer T (iNKT) cells (J�18(-/-) ), or interleukin-13 (IL-13(-/-) ) had impaired early... | false | note_62 | note_62_ the pneumonia model, | 176 |
note_63_span_Aged_100000_150000_mid_mesh | toxicity. However, | Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic<think> to our knowledge, few studies have evaluated this in US populations.Objective: Our objective was to exa... | true | note_63 | note_63_ toxicity. However, | 177 |
note_63_span_Aged_100000_150000_mid_mesh | used weighted quantile | Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective... | true | note_63 | note_63_ used weighted quantile | 178 |
note_63_span_Aged_100000_150000_mid_mesh | a marker of | Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective... | true | note_63 | note_63_ a marker of | 179 |
note_63_span_Aged_100000_150000_mid_mesh | and potential risk factor | Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective... | true | note_63 | note_63_ and potential risk factor | 180 |
note_63_span_Cell Line, Tumor_100000_150000_mid_mesh | of cardiovascular disease | Background: Arsenic exposure has been associated with an increased risk<think> (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective was to examine wh... | false | note_63 | note_63_ of cardiovascular disease | 181 |
note_64_span_Signal Transduction_100000_150000_mid_mesh | of patients receiving | BACKGROUND: The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of l... | true | note_64 | note_64_ of patients receiving | 182 |
note_64_span_Signal Transduction_100000_150000_mid_mesh | daily patient fluid balance, | BACKGROUND: The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of l... | true | note_64 | note_64_ daily patient fluid balance, | 183 |
note_64_span_Signal Transduction_100000_150000_mid_mesh | fluid goal.CONCLUSION: | BACKGROUND: The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of l... | true | note_64 | note_64_ fluid goal.CONCLUSION: | 184 |
note_64_span_Mice_100000_150000_mid_mesh | BACKGROUND: | <think> The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of liter... | false | note_64 | note_64_BACKGROUND: | 185 |
note_65_span_Pregnancy_100000_150000_mid_mesh | Michigan dairy herds. | The objective of this study was to determine the herd-level variables that were associated with total stimulation time during the premilking routine in 64<think> The mean herd size was 452 cows (range = 59 to 2,771 cows). For each herd, surveys were administered to producers to gather mastitis management practices and... | false | note_65 | note_65_ Michigan dairy herds. | 186 |
note_65_span_Adolescent_100000_150000_mid_mesh | this study was | The objective of<think> to determine the herd-level variables that were associated with total stimulation time during the premilking routine in 64 Michigan dairy herds. The mean herd size was 452 cows (range = 59 to 2,771 cows). For each herd, surveys were administered to producers to gather mastitis management practi... | false | note_65 | note_65_ this study was | 187 |
note_65_span_Adolescent_100000_150000_mid_mesh | adequate tactile stimulation | The objective of this study was to determine the herd-level variables that were associated with total stimulation time during the premilking routine in 64 Michigan dairy herds. The mean herd size was 452 cows (range = 59 to 2,771 cows). For each herd, surveys were administered to producers to gather mastitis management... | true | note_65 | note_65_ adequate tactile stimulation | 188 |
note_66_span_Animals_100000_150000_mid_mesh | This study investigated | BACKGROUND: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract.<think>... | false | note_66 | note_66_ This study investigated | 189 |
note_66_span_Animals_100000_150000_mid_mesh | 1�12).CONCLUSION: | BACKGROUND: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract. This s... | true | note_66 | note_66_ 1�12).CONCLUSION: | 190 |
note_66_span_Animals_100000_150000_mid_mesh | the pathology carries | BACKGROUND: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract. This s... | true | note_66 | note_66_ the pathology carries | 191 |
note_66_span_Animals_100000_150000_mid_mesh | should stimulate discussion | BACKGROUND: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract. This s... | true | note_66 | note_66_ should stimulate discussion | 192 |
note_66_span_Pregnancy_100000_150000_mid_mesh | 000 emergency laparotomies | BACKGROUND: Approximately 30<think> are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract. This study investigated t... | false | note_66 | note_66_ 000 emergency laparotomies | 193 |
note_66_span_Pregnancy_100000_150000_mid_mesh | on mortality after emergency | BACKGROUND: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused on either the upper or lower gastrointestinal tract. This s... | true | note_66 | note_66_ on mortality after emergency | 194 |
note_67_span_Treatment Outcome_100000_150000_mid_mesh | new treatments for | Jun?n arenavirus infections are associated with high levels of interferons in both severe and fatal cases. Upon Jun?n virus (JUNV) infection a cell signaling cascade initiates, that ultimately attempts to limit viral replication and prevent infection progression through the expression of host antiviral proteins. The in... | false | note_67 | note_67_ new treatments for | 197 |
note_67_span_Risk Factors_100000_150000_mid_mesh | and fatal cases. | Jun?n arenavirus infections are associated with high levels of interferons in both severe<think> Upon Jun?n virus (JUNV) infection a cell signaling cascade initiates, that ultimately attempts to limit viral replication and prevent infection progression through the expression of host antiviral proteins. The interferon ... | false | note_67 | note_67_ and fatal cases. | 198 |
note_67_span_Risk Factors_100000_150000_mid_mesh | viral disease | Jun?n arenavirus infections are associated with high levels of interferons in both severe and fatal cases. Upon Jun?n virus (JUNV) infection a cell signaling cascade initiates, that ultimately attempts to limit viral replication and prevent infection progression through the expression of host antiviral proteins. The in... | true | note_67 | note_67_ viral disease | 199 |
note_68_span_Mice_100000_150000_mid_mesh | OBJECTIVE: | <think> The aim of this study was to describe emergency department (ED) activities and staffing after the introduction of activity-based funding (ABF) to highlight the challenges of new funding arrangements and their implementation.METHODS: A retrospective study of public hospital EDs in Queensland, Australia, was unde... | false | note_68 | note_68_OBJECTIVE: | 200 |
note_68_span_Time Factors_100000_150000_mid_mesh | 4�hours ranged | OBJECTIVE: The aim of this study was to describe emergency department (ED) activities and staffing after the introduction of activity-based funding (ABF) to highlight the challenges of new funding arrangements and their implementation.METHODS: A retrospective study of public hospital EDs in Queensland, Australia, was u... | false | note_68 | note_68_ 4�hours ranged | 201 |
note_69_span_Male_100000_150000_mid_mesh | of parents whose children | STUDY OBJECTIVES: To explore the perceptions and experiences<think> were using melatonin.METHODS: A qualitative exploratory study was undertaken using face-to-face semi-structured interviews that were audio recorded and transcribed verbatim. Data was thematically analyzed via open coding and subsequent axial coding. D... | false | note_69 | note_69_ of parents whose children | 202 |
note_69_span_Mice_100000_150000_mid_mesh | using melatonin.METHODS: | STUDY OBJECTIVES: To explore the perceptions and experiences of parents whose children were<think> A qualitative exploratory study was undertaken using face-to-face semi-structured interviews that were audio recorded and transcribed verbatim. Data was thematically analyzed via open coding and subsequent axial coding. ... | true | note_69 | note_69_ using melatonin.METHODS: | 203 |
note_70_span_Cell Line, Tumor_100000_150000_mid_mesh | and� material used to detect | The aim of this study is to assess the association among species of bacteria and to identify the presence of clusters of patients in sub intensive care unit with different profiles of infection, and to study the relationship between such profiles and patient demographics (gender, age), kind of investigations<think> th... | false | note_70 | note_70_ and� material used to detect | 204 |
note_71_span_Male_100000_150000_mid_mesh | of adolescents living | COVID-19 social control measures (e.g. physical distancing and lockdowns) can have both immediate (social isolation, loneliness, anxiety, stress) and long-term effects (depression, post-traumatic stress disorder) on individuals' mental health. This may be particularly true<think> with HIV (ALHIV) and their caregivers ... | false | note_71 | note_71_ of adolescents living | 205 |
note_71_span_Time Factors_100000_150000_mid_mesh | COVID-19 | <think> social control measures (e.g. physical distancing and lockdowns) can have both immediate (social isolation, loneliness, anxiety, stress) and long-term effects (depression, post-traumatic stress disorder) on individuals' mental health. This may be particularly true of adolescents living with HIV (ALHIV) and thei... | false | note_71 | note_71_COVID-19 | 206 |
note_71_span_Time Factors_100000_150000_mid_mesh | both immediate (social | COVID-19 social control measures (e.g. physical distancing and lockdowns) can have<think> isolation, loneliness, anxiety, stress) and long-term effects (depression, post-traumatic stress disorder) on individuals' mental health. This may be particularly true of adolescents living with HIV (ALHIV) and their caregivers -... | true | note_71 | note_71_ both immediate (social | 207 |
note_71_span_Time Factors_100000_150000_mid_mesh | and long-term | COVID-19 social control measures (e.g. physical distancing and lockdowns) can have both immediate (social isolation, loneliness, anxiety, stress)<think> effects (depression, post-traumatic stress disorder) on individuals' mental health. This may be particularly true of adolescents living with HIV (ALHIV) and their car... | true | note_71 | note_71_ and long-term | 208 |
note_72_span_Male_100000_150000_mid_mesh | Pomegranate juice | <think> is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicken breast f... | false | note_72 | note_72_Pomegranate juice | 209 |
note_72_span_Male_100000_150000_mid_mesh | this study, two pomegranate | Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In<think> based marinades were prepared for the marination of chicken breast fillets and... | true | note_72 | note_72_ this study, two pomegranate | 210 |
note_72_span_Male_100000_150000_mid_mesh | chicken breast fillets | Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of<think>... | true | note_72 | note_72_ chicken breast fillets | 211 |
note_72_span_Male_100000_150000_mid_mesh | pomegranate juice could | Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicke... | true | note_72 | note_72_ pomegranate juice could | 212 |
note_72_span_Aged_100000_150000_mid_mesh | that could be | Pomegranate juice is a product with enhanced functional properties<think> used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicken brea... | false | note_72 | note_72_ that could be | 213 |
note_72_span_Aged_100000_150000_mid_mesh | were aerobically | Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicke... | true | note_72 | note_72_ were aerobically | 214 |
note_72_span_Aged_100000_150000_mid_mesh | shelf life of chicken meat | Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicke... | true | note_72 | note_72_ shelf life of chicken meat | 215 |
note_73_span_Risk Factors_100000_150000_mid_mesh | Cocaine-related deaths have | <think> increased since the early 1990s in Europe, including the UK. Being multi-factorial, they are difficult to define, detect and record. The European Monitoring Centre for Drugs and Drug Addiction commissioned research to: describe trends reported to Special Mortality Registries and General Mortality Registers; pro... | false | note_73 | note_73_Cocaine-related deaths have | 216 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.