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note_1_span_Disease Models, Animal_100000_150000_mid_mesh | inflammatory diseases. | Leucocyte recruitment is critical during many acute and chronic<unused6241> Chemokines are key mediators of leucocyte recruitment during the inflammatory response, by signalling through specific chemokine G-protein-coupled receptors (GPCRs). In addition, chemokines interact with cell-surface glycosaminoglycans (GAGs) ... | false | note_1 | note_1_ inflammatory diseases. | 0 |
note_1_span_Aged_100000_150000_mid_mesh | of therapeutic inhibitors | Leucocyte recruitment is critical during many acute and chronic inflammatory diseases. Chemokines are key mediators of leucocyte recruitment during the inflammatory response, by signalling through specific chemokine G-protein-coupled receptors (GPCRs). In addition, chemokines interact with cell-surface glycosaminoglyca... | false | note_1 | note_1_ of therapeutic inhibitors | 1 |
note_2_span_Disease Models, Animal_100000_150000_mid_mesh | and disease-free | PURPOSE: The Exercise for Health trials were randomised, controlled trials designed to evaluate an 8-month pragmatic exercise intervention, commencing 6�weeks post-surgery for women with newly diagnosed breast cancer residing in urban or rural/regional Australia. For these exploratory analyses, the primary and secondar... | true | note_2 | note_2_ and disease-free | 2 |
note_2_span_Pregnancy_100000_150000_mid_mesh | 8-month pragmatic exercise | PURPOSE: The Exercise for Health trials were randomised, controlled trials designed to evaluate an<unused6241> intervention, commencing 6�weeks post-surgery for women with newly diagnosed breast cancer residing in urban or rural/regional Australia. For these exploratory analyses, the primary and secondary outcomes wer... | false | note_2 | note_2_ 8-month pragmatic exercise | 3 |
note_2_span_Pregnancy_100000_150000_mid_mesh | for women with | PURPOSE: The Exercise for Health trials were randomised, controlled trials designed to evaluate an 8-month pragmatic exercise intervention, commencing 6�weeks post-surgery<unused6241> newly diagnosed breast cancer residing in urban or rural/regional Australia. For these exploratory analyses, the primary and secondary ... | true | note_2 | note_2_ for women with | 4 |
note_3_span_Male_100000_150000_mid_mesh | that infertility qualifies | The Canadian province of Quebec recently amended its Health Insurance Act to cover the costs of In Vitro Fertilization (IVF). The province of Ontario recently de-insured IVF. Both provinces cited cost-effectiveness as their grounds, but the question as to whether a public health insurance system ought to cover IVF rais... | false | note_3 | note_3_ that infertility qualifies | 5 |
note_3_span_Pregnancy_100000_150000_mid_mesh | understand reproduction at | The Canadian province of Quebec recently amended its Health Insurance Act to cover the costs of In Vitro Fertilization (IVF). The province of Ontario recently de-insured IVF. Both provinces cited cost-effectiveness as their grounds, but the question as to whether a public health insurance system ought to cover IVF rais... | false | note_3 | note_3_ understand reproduction at | 6 |
note_4_span_Male_100000_150000_mid_mesh | for genistein, | The present research was concerned with preparation of mesoporous starch (MPS) as a carrier<unused6241> a model of poorly water-soluble phytoestrogen isoflavone; and exploration of the impact of different fabrication parameters on structural and loading properties. MPS is considered as a highly porous biomaterial whic... | false | note_4 | note_4_ for genistein, | 8 |
note_4_span_Male_100000_150000_mid_mesh | phytoestrogen isoflavone; | The present research was concerned with preparation of mesoporous starch (MPS) as a carrier for genistein, a model of poorly water-soluble<unused6241> and exploration of the impact of different fabrication parameters on structural and loading properties. MPS is considered as a highly porous biomaterial which typically... | true | note_4 | note_4_ phytoestrogen isoflavone; | 9 |
note_6_span_Aged_100000_150000_mid_mesh | Organ fibrosis or "scarring" | <unused6241> is known to account for a high death toll due to the extensive amount of disorders and organs affected (from cirrhosis to cardiovascular diseases). There is no effective treatment and the in vitro tools available do not mimic the in vivo situation rendering the progress of the out of control wound healing ... | false | note_6 | note_6_Organ fibrosis or "scarring" | 11 |
note_6_span_Aged_100000_150000_mid_mesh | As a way to | Organ fibrosis or "scarring" is known to account for a high death toll due to the extensive amount of disorders and organs affected (from cirrhosis to cardiovascular diseases). There is no effective treatment and the in vitro tools available do not mimic the in vivo situation rendering the progress of the out of contro... | true | note_6 | note_6_ As a way to | 12 |
note_6_span_Aged_100000_150000_mid_mesh | vivo situation. | Organ fibrosis or "scarring" is known to account for a high death toll due to the extensive amount of disorders and organs affected (from cirrhosis to cardiovascular diseases). There is no effective treatment and the in vitro tools available do not mimic the in vivo situation rendering the progress of the out of contro... | true | note_6 | note_6_ vivo situation. | 13 |
note_6_span_Time Factors_100000_150000_mid_mesh | Real-time PCR | Organ fibrosis or "scarring" is known to account for a high death toll due to the extensive amount of disorders and organs affected (from cirrhosis to cardiovascular diseases). There is no effective treatment and the in vitro tools available do not mimic the in vivo situation rendering the progress of the out of contro... | false | note_6 | note_6_ Real-time PCR | 14 |
note_7_span_Male_100000_150000_mid_mesh | BT-474 is | BACKGROUND: The cell line<unused6241> a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific commu... | false | note_7 | note_7_ BT-474 is | 15 |
note_7_span_Animals_100000_150000_mid_mesh | published genome sequence | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete,<unused6241> for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific community by generati... | false | note_7 | note_7_ published genome sequence | 16 |
note_7_span_Animals_100000_150000_mid_mesh | this study we sought | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In<unused6241> to provide a comprehensive and useful data set for the scientific community by gen... | true | note_7 | note_7_ this study we sought | 17 |
note_7_span_Animals_100000_150000_mid_mesh | BT-474.FINDINGS: | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific communit... | true | note_7 | note_7_ BT-474.FINDINGS: | 18 |
note_7_span_Animals_100000_150000_mid_mesh | individual cells to | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific communit... | true | note_7 | note_7_ individual cells to | 19 |
note_7_span_Animals_100000_150000_mid_mesh | technology.CONCLUSIONS: | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific communit... | true | note_7 | note_7_ technology.CONCLUSIONS: | 20 |
note_7_span_Animals_100000_150000_mid_mesh | complex genome sequence. | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific communit... | true | note_7 | note_7_ complex genome sequence. | 21 |
note_7_span_Animals_100000_150000_mid_mesh | coverage genome sequence | BACKGROUND: The cell line BT-474 is a popular cell line for studying the biology of cancer and developing novel drugs. However, there is no complete, published genome sequence for this highly utilized scientific resource. In this study we sought to provide a comprehensive and useful data set for the scientific communit... | true | note_7 | note_7_ coverage genome sequence | 22 |
note_8_span_Aged_100000_150000_mid_mesh | Context: Myonectin | <unused6241> has been identified as a myokine, expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown.Objective: The aim of this study is to investigate the relationship between myonectin (C1q tumor necrosis factor-�-related protein isoform 15) and type 2 diabetes mellitus (T... | false | note_8 | note_8_Context: Myonectin | 23 |
note_8_span_Aged_100000_150000_mid_mesh | prediabetes and diabetes | Context: Myonectin has been identified as a myokine, expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown.Objective: The aim of this study is to investigate the relationship between myonectin (C1q tumor necrosis factor-�-related protein isoform 15) and type 2 diabetes melli... | true | note_8 | note_8_ prediabetes and diabetes | 24 |
note_8_span_Male_100000_150000_mid_mesh | a myokine, | Context: Myonectin has been identified as<unused6241> expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown.Objective: The aim of this study is to investigate the relationship between myonectin (C1q tumor necrosis factor-�-related protein isoform 15) and type 2 diabetes mel... | false | note_8 | note_8_ a myokine, | 25 |
note_8_span_Male_100000_150000_mid_mesh | 128 healthy individuals | Context: Myonectin has been identified as a myokine, expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown.Objective: The aim of this study is to investigate the relationship between myonectin (C1q tumor necrosis factor-�-related protein isoform 15) and type 2 diabetes melli... | true | note_8 | note_8_ 128 healthy individuals | 26 |
note_9_span_Risk Factors_100000_150000_mid_mesh | This paper presents | <unused6241> an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian radial ... | false | note_9 | note_9_This paper presents | 28 |
note_9_span_Risk Factors_100000_150000_mid_mesh | tomography. The conductivity | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance<unused6241> to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian radial basis fun... | true | note_9 | note_9_ tomography. The conductivity | 29 |
note_9_span_Risk Factors_100000_150000_mid_mesh | the anomaly was | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of<unused6241> represented by a shape-based PLS function, which we represent using Gaussian rad... | true | note_9 | note_9_ the anomaly was | 30 |
note_9_span_Risk Factors_100000_150000_mid_mesh | lung imaging. In | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian ... | true | note_9 | note_9_ lung imaging. In | 31 |
note_9_span_Risk Factors_100000_150000_mid_mesh | method w.r.t | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian ... | true | note_9 | note_9_ method w.r.t | 32 |
note_9_span_Treatment Outcome_100000_150000_mid_mesh | EIT: lung imaging. | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian ... | true | note_9 | note_9_ EIT: lung imaging. | 34 |
note_9_span_Treatment Outcome_100000_150000_mid_mesh | simulated lung imaging data. | This paper presents an image reconstruction method based on parametric level set (PLS) method using electrical impedance tomography. The conductivity to be reconstructed was assumed to be piecewise constant and the geometry of the anomaly was represented by a shape-based PLS function, which we represent using Gaussian ... | true | note_9 | note_9_ simulated lung imaging data. | 35 |
note_10_span_Mice_100000_150000_mid_mesh | OBJECTIVE: | <unused6241> To describe indications and outcomes of patients fitted with the EyePrintPRO therapeutic scleral lens.METHODS: A database search of patients fitted with the EyePrintPRO from 2014 to 2016. Fourteen eyes of 10 patients were reviewed retrospectively. Patient demographics, medical and ocular history, indicatio... | false | note_10 | note_10_OBJECTIVE: | 36 |
note_11_span_Time Factors_100000_150000_mid_mesh | BACKGROUND: | <unused6241> The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.RESULTS: At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Pr... | false | note_11 | note_11_BACKGROUND: | 37 |
note_11_span_Time Factors_100000_150000_mid_mesh | present study was | BACKGROUND: The goal of the<unused6241> to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.RESULTS: At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Proteoba... | true | note_11 | note_11_ present study was | 38 |
note_11_span_Time Factors_100000_150000_mid_mesh | the effects of TAK-242 | BACKGROUND: The goal of the present study was to investigate<unused6241> on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.RESULTS: At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Proteobacteri... | true | note_11 | note_11_ the effects of TAK-242 | 39 |
note_11_span_Time Factors_100000_150000_mid_mesh | the TLR4/JAK2/STAT3 | BACKGROUND: The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and<unused6241> signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.RESULTS: At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Proteobact... | true | note_11 | note_11_ the TLR4/JAK2/STAT3 | 40 |
note_11_span_Time Factors_100000_150000_mid_mesh | colitis.RESULTS: | BACKGROUND: The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced<unused6241> At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Proteob... | true | note_11 | note_11_ colitis.RESULTS: | 41 |
note_11_span_Time Factors_100000_150000_mid_mesh | phosphorylation.CONCLUSION: | BACKGROUND: The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.RESULTS: At the phylum level, Bacteroidetes, Firmicutes, Actinobacteria, Cyanobacteria, Epsilonbacteraeota and Pro... | true | note_11 | note_11_ phosphorylation.CONCLUSION: | 42 |
note_12_span_Adolescent_100000_150000_mid_mesh | regarding age, | BACKGROUND: The COVID-19 infodemic, a surge of information and misinformation, has sparked worry about the public's perception of the coronavirus pandemic. Excessive information and misinformation can lead to belief in false information as well as reduce the accurate interpretation of true information. Such incorrect b... | false | note_12 | note_12_ regarding age, | 43 |
note_12_span_Animals_100000_150000_mid_mesh | virus.OBJECTIVE: | BACKGROUND: The COVID-19 infodemic, a surge of information and misinformation, has sparked worry about the public's perception of the coronavirus pandemic. Excessive information and misinformation can lead to belief in false information as well as reduce the accurate interpretation of true information. Such incorrect b... | false | note_12 | note_12_ virus.OBJECTIVE: | 44 |
note_12_span_Animals_100000_150000_mid_mesh | this study was | BACKGROUND: The COVID-19 infodemic, a surge of information and misinformation, has sparked worry about the public's perception of the coronavirus pandemic. Excessive information and misinformation can lead to belief in false information as well as reduce the accurate interpretation of true information. Such incorrect b... | true | note_12 | note_12_ this study was | 45 |
note_12_span_Animals_100000_150000_mid_mesh | in scientists (ie, | BACKGROUND: The COVID-19 infodemic, a surge of information and misinformation, has sparked worry about the public's perception of the coronavirus pandemic. Excessive information and misinformation can lead to belief in false information as well as reduce the accurate interpretation of true information. Such incorrect b... | true | note_12 | note_12_ in scientists (ie, | 46 |
note_14_span_Risk Factors_100000_150000_mid_mesh | lower risks of | Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n�=�120�756) aged ?45�years diagnosed with AF in Sweden diagnosed for t... | false | note_14 | note_14_ lower risks of | 47 |
note_14_span_Risk Factors_100000_150000_mid_mesh | higher risk of | Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n�=�120�756) aged ?45�years diagnosed with AF in Sweden diagnosed for t... | true | note_14 | note_14_ higher risk of | 48 |
note_14_span_Mice_100000_150000_mid_mesh | in patients with AF | Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n�=�120�756) aged ?45�years diagnosed with AF in Sweden diagnosed for t... | false | note_14 | note_14_ in patients with AF | 49 |
note_15_span_Aged_100000_150000_mid_mesh | Several potential CaMKII | BACKGROUND: Voltage-gated Na(+) channels (Nav) are essential for myocyte membrane excitability and cardiac function. Nav current (INa) is a large-amplitude, short-duration spike generated by rapid channel activation followed immediately by inactivation. However, even under normal conditions, a small late component of I... | false | note_15 | note_15_ Several potential CaMKII | 50 |
note_15_span_Pregnancy_100000_150000_mid_mesh | both congenital and | BACKGROUND: Voltage-gated Na(+) channels (Nav) are essential for myocyte membrane excitability and cardiac function. Nav current (INa) is a large-amplitude, short-duration spike generated by rapid channel activation followed immediately by inactivation. However, even under normal conditions, a small late component of I... | false | note_15 | note_15_ both congenital and | 51 |
note_16_span_Pregnancy_100000_150000_mid_mesh | mice prenatally exposed | Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high human and economic burden. The pathophysiology of ASD is largely unclear, thus hampering development of pharmacological treatments for the core symptoms of the disorder. Abnormalities in glutamate and GABA signaling have been hypothes... | false | note_16 | note_16_ mice prenatally exposed | 52 |
note_16_span_Risk Factors_100000_150000_mid_mesh | human and economic burden. | Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high<unused6241> The pathophysiology of ASD is largely unclear, thus hampering development of pharmacological treatments for the core symptoms of the disorder. Abnormalities in glutamate and GABA signaling have been hypothesized to underl... | false | note_16 | note_16_ human and economic burden. | 53 |
note_18_span_Risk Factors_100000_150000_mid_mesh | present study, | By means of guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTP�S) binding assay combined with immunoprecipitation using anti-G� subunit antibody, we recently reported 5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated G�q activation in rat cerebral cortical membranes (Odagaki et al., 2014). In the<u... | false | note_18 | note_18_ present study, | 54 |
note_18_span_Risk Factors_100000_150000_mid_mesh | postmortem human brains, | By means of guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTP�S) binding assay combined with immunoprecipitation using anti-G� subunit antibody, we recently reported 5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated G�q activation in rat cerebral cortical membranes (Odagaki et al., 2014). In the p... | true | note_18 | note_18_ postmortem human brains, | 55 |
note_18_span_Risk Factors_100000_150000_mid_mesh | A1 receptor is | By means of guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTP�S) binding assay combined with immunoprecipitation using anti-G� subunit antibody, we recently reported 5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated G�q activation in rat cerebral cortical membranes (Odagaki et al., 2014). In the p... | true | note_18 | note_18_ A1 receptor is | 56 |
note_19_span_Disease Models, Animal_100000_150000_mid_mesh | This study investigated | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ This study investigated | 58 |
note_19_span_Disease Models, Animal_100000_150000_mid_mesh | on appetite.METHODS: | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ on appetite.METHODS: | 59 |
note_19_span_Disease Models, Animal_100000_150000_mid_mesh | fast, subjects with | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ fast, subjects with | 60 |
note_19_span_Disease Models, Animal_100000_150000_mid_mesh | lowered plasma ghrelin | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ lowered plasma ghrelin | 61 |
note_19_span_Disease Models, Animal_100000_150000_mid_mesh | and desire to eat | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ and desire to eat | 62 |
note_19_span_Pregnancy_100000_150000_mid_mesh | Increased blood ketone | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | false | note_19 | note_19_ Increased blood ketone | 63 |
note_19_span_Pregnancy_100000_150000_mid_mesh | to eat | OBJECTIVE: The ketones d-�-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones... | true | note_19 | note_19_ to eat | 64 |
note_20_span_Time Factors_100000_150000_mid_mesh | tobacco products.OBJECTIVE: | RATIONALE: Behavioral economic measures of demand provide estimates of tobacco product abuse liability and may predict effects of policy-related price regulation on consumption of existing and emerging<unused6241> In the present study, we examined demand for snus, a smokeless tobacco product, in comparison to both cig... | true | note_20 | note_20_ tobacco products.OBJECTIVE: | 65 |
note_20_span_Time Factors_100000_150000_mid_mesh | across tasks.CONCLUSIONS: | RATIONALE: Behavioral economic measures of demand provide estimates of tobacco product abuse liability and may predict effects of policy-related price regulation on consumption of existing and emerging tobacco products.OBJECTIVE: In the present study, we examined demand for snus, a smokeless tobacco product, in compari... | true | note_20 | note_20_ across tasks.CONCLUSIONS: | 66 |
note_20_span_Time Factors_100000_150000_mid_mesh | existing smokers | RATIONALE: Behavioral economic measures of demand provide estimates of tobacco product abuse liability and may predict effects of policy-related price regulation on consumption of existing and emerging tobacco products.OBJECTIVE: In the present study, we examined demand for snus, a smokeless tobacco product, in compari... | true | note_20 | note_20_ existing smokers | 67 |
note_20_span_Animals_100000_150000_mid_mesh | present study, we | RATIONALE: Behavioral economic measures of demand provide estimates of tobacco product abuse liability and may predict effects of policy-related price regulation on consumption of existing and emerging tobacco products.OBJECTIVE: In the<unused6241> examined demand for snus, a smokeless tobacco product, in comparison t... | true | note_20 | note_20_ present study, we | 68 |
note_20_span_Animals_100000_150000_mid_mesh | or nicotine gum | RATIONALE: Behavioral economic measures of demand provide estimates of tobacco product abuse liability and may predict effects of policy-related price regulation on consumption of existing and emerging tobacco products.OBJECTIVE: In the present study, we examined demand for snus, a smokeless tobacco product, in compari... | true | note_20 | note_20_ or nicotine gum | 69 |
note_21_span_Prognosis_100000_150000_mid_mesh | accurate prediction of | An<unused6241> achievable dose distribution on a patient specific basis would greatly improve IMRT/VMAT planning in both efficiency and quality. Recently machine learning techniques have been proposed for IMRT dose prediction based on patient's contour information from planning CT. In these existing prediction models ... | false | note_21 | note_21_ accurate prediction of | 71 |
note_21_span_Prognosis_100000_150000_mid_mesh | the prostate cancer patients | An accurate prediction of achievable dose distribution on a patient specific basis would greatly improve IMRT/VMAT planning in both efficiency and quality. Recently machine learning techniques have been proposed for IMRT dose prediction based on patient's contour information from planning CT. In these existing predicti... | true | note_21 | note_21_ the prostate cancer patients | 72 |
note_22_span_Time Factors_100000_150000_mid_mesh | 9-o'clock positions. | PURPOSE: To examine extraocular rectus muscle tendons in patients with Graves' ophthalmopathy using optical coherence tomography (OCT).METHODS: This was a cross-sectional observational study conducted with 55 healthy controls, 45 patients with clinically inactive Graves' ophthalmopathy, and 12 patients with clinically ... | false | note_22 | note_22_ 9-o'clock positions. | 74 |
note_22_span_Time Factors_100000_150000_mid_mesh | 2018;55(6):356-362.] | PURPOSE: To examine extraocular rectus muscle tendons in patients with Graves' ophthalmopathy using optical coherence tomography (OCT).METHODS: This was a cross-sectional observational study conducted with 55 healthy controls, 45 patients with clinically inactive Graves' ophthalmopathy, and 12 patients with clinically ... | true | note_22 | note_22_ 2018;55(6):356-362.] | 75 |
note_22_span_Disease Models, Animal_100000_150000_mid_mesh | inactive disease. | PURPOSE: To examine extraocular rectus muscle tendons in patients with Graves' ophthalmopathy using optical coherence tomography (OCT).METHODS: This was a cross-sectional observational study conducted with 55 healthy controls, 45 patients with clinically inactive Graves' ophthalmopathy, and 12 patients with clinically ... | false | note_22 | note_22_ inactive disease. | 76 |
note_23_span_Mice_100000_150000_mid_mesh | PRMT5, which | <unused6241> regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a pathogenic role in many cancers. In diffuse large B cell lymphoma (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely unknown. Here we dem... | false | note_23 | note_23_PRMT5, which | 77 |
note_23_span_Mice_100000_150000_mid_mesh | a mechanistic rationale for | PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a pathogenic role in many cancers. In diffuse large B cell lymphoma (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely unknown. Here we dem... | true | note_23 | note_23_ a mechanistic rationale for | 78 |
note_23_span_Prognosis_100000_150000_mid_mesh | pathogenic role | PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a<unused6241> in many cancers. In diffuse large B cell lymphoma (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely unknown. Here we demons... | false | note_23 | note_23_ pathogenic role | 79 |
note_23_span_Prognosis_100000_150000_mid_mesh | many cancers. | PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a pathogenic role in<unused6241> In diffuse large B cell lymphoma (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely unknown. Here we demo... | true | note_23 | note_23_ many cancers. | 80 |
note_23_span_Prognosis_100000_150000_mid_mesh | cell lymphoma | PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a pathogenic role in many cancers. In diffuse large B<unused6241> (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely unknown. Here we demo... | true | note_23 | note_23_ cell lymphoma | 81 |
note_24_span_Cell Line, Tumor_100000_150000_mid_mesh | (P<0.001).CONCLUSIONS: | PURPOSE: To determine the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) peak and fluctuation induced by the water drinking test (WDT) in patients with open-angle glaucoma and ocular hypertension.METHODS: Patients with open-angle glaucoma or ocular hypertension underwent the WDT before an... | false | note_24 | note_24_ (P<0.001).CONCLUSIONS: | 82 |
note_24_span_Time Factors_100000_150000_mid_mesh | hypertension.METHODS: | PURPOSE: To determine the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) peak and fluctuation induced by the water drinking test (WDT) in patients with open-angle glaucoma and ocular<unused6241> Patients with open-angle glaucoma or ocular hypertension underwent the WDT before and after S... | false | note_24 | note_24_ hypertension.METHODS: | 83 |
note_24_span_Time Factors_100000_150000_mid_mesh | 12-month period. | PURPOSE: To determine the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) peak and fluctuation induced by the water drinking test (WDT) in patients with open-angle glaucoma and ocular hypertension.METHODS: Patients with open-angle glaucoma or ocular hypertension underwent the WDT before an... | true | note_24 | note_24_ 12-month period. | 84 |
note_24_span_Time Factors_100000_150000_mid_mesh | and every 15 minutes for | PURPOSE: To determine the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) peak and fluctuation induced by the water drinking test (WDT) in patients with open-angle glaucoma and ocular hypertension.METHODS: Patients with open-angle glaucoma or ocular hypertension underwent the WDT before an... | true | note_24 | note_24_ and every 15 minutes for | 85 |
note_26_span_Cell Line, Tumor_100000_150000_mid_mesh | BNP.CONCLUSION: | OBJECTIVE: Renal dysfunction is associated with increased cardiovascular morbidity and mortality. The alteration in renal function as a marker of mortality in pulmonary thromboembolism (PTE) has not been studied extensively.METHODS: Four hundred four consecutive patients diagnosed with non-high-risk PTE (without cardio... | false | note_26 | note_26_ BNP.CONCLUSION: | 86 |
note_26_span_Aged_100000_150000_mid_mesh | OBJECTIVE: Renal | <unused6241> dysfunction is associated with increased cardiovascular morbidity and mortality. The alteration in renal function as a marker of mortality in pulmonary thromboembolism (PTE) has not been studied extensively.METHODS: Four hundred four consecutive patients diagnosed with non-high-risk PTE (without cardiogeni... | false | note_26 | note_26_OBJECTIVE: Renal | 87 |
note_27_span_Animals_100000_150000_mid_mesh | this study was | Extracellular matrix (ECM) is a rich network of proteins and proteoglycans that has proved to be very useful in tissue regeneration. Porcine ECM has been proposed as a biological scaffold, and urinary bladder matrix (UBM) has demonstrated superior biological properties; however, its use in human treatment requires ensu... | false | note_27 | note_27_ this study was | 89 |
note_27_span_Cell Line, Tumor_100000_150000_mid_mesh | decellularization | Extracellular matrix (ECM) is a rich network of proteins and proteoglycans that has proved to be very useful in tissue regeneration. Porcine ECM has been proposed as a biological scaffold, and urinary bladder matrix (UBM) has demonstrated superior biological properties; however, its use in human treatment requires ensu... | true | note_27 | note_27_ decellularization | 90 |
note_27_span_Cell Line, Tumor_100000_150000_mid_mesh | porcine housekeeping gene | Extracellular matrix (ECM) is a rich network of proteins and proteoglycans that has proved to be very useful in tissue regeneration. Porcine ECM has been proposed as a biological scaffold, and urinary bladder matrix (UBM) has demonstrated superior biological properties; however, its use in human treatment requires ensu... | true | note_27 | note_27_ porcine housekeeping gene | 91 |
note_28_span_Time Factors_100000_150000_mid_mesh | during cerebral ischemia. | Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes<unused6241> The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS) expression in D-galactose-induced senescent astrocytes exposed t... | true | note_28 | note_28_ during cerebral ischemia. | 93 |
note_28_span_Time Factors_100000_150000_mid_mesh | this study was | Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of<unused6241> to investigate the effects of carnosine on cell damage and glutamine synthetase (GS) expression in D-galactose-induced senescent astrocyte... | true | note_28 | note_28_ this study was | 94 |
note_28_span_Surveys and Questionnaires_100000_150000_mid_mesh | few reports concern | Carnosine is believed to be neuroprotective in cerebral ischemia. However,<unused6241> its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS) expression in D-galactose-induced senescent astrocytes exp... | false | note_28 | note_28_ few reports concern | 95 |
note_29_span_Aged_100000_150000_mid_mesh | respectively).CONCLUSION: | PURPOSE: Treatment modalities for glottic cancer comprise surgery, (chemo-)radiation, and combined treatment options. Glottic cancer involving the anterior commissure (AC) requires special preoperative assessment and surgical skills, as it is commonly considered a risk factor for local recurrence. The aim of this study... | false | note_29 | note_29_ respectively).CONCLUSION: | 97 |
note_29_span_Adolescent_100000_150000_mid_mesh | involvement in patients with | PURPOSE: Treatment modalities for glottic cancer comprise surgery, (chemo-)radiation, and combined treatment options. Glottic cancer involving the anterior commissure (AC) requires special preoperative assessment and surgical skills, as it is commonly considered a risk factor for local recurrence. The aim of this study... | true | note_29 | note_29_ involvement in patients with | 99 |
note_29_span_Adolescent_100000_150000_mid_mesh | laryngeal | PURPOSE: Treatment modalities for glottic cancer comprise surgery, (chemo-)radiation, and combined treatment options. Glottic cancer involving the anterior commissure (AC) requires special preoperative assessment and surgical skills, as it is commonly considered a risk factor for local recurrence. The aim of this study... | true | note_29 | note_29_ laryngeal | 100 |
note_31_span_Animals_100000_150000_mid_mesh | DUD symptoms (PR�=�1.97, | BACKGROUND: The U.S.-Mexico border displays elevated rates of hazardous alcohol and drug use. Whether the co-occurrence of alcohol and drug use and disorders is also high in the border area is unknown.METHODS: Data are from the U.S.-Mexico Study on Alcohol and Related Conditions, a cross-sectional survey of randomly se... | false | note_31 | note_31_ DUD symptoms (PR�=�1.97, | 101 |
note_31_span_Animals_100000_150000_mid_mesh | border population | BACKGROUND: The U.S.-Mexico border displays elevated rates of hazardous alcohol and drug use. Whether the co-occurrence of alcohol and drug use and disorders is also high in the border area is unknown.METHODS: Data are from the U.S.-Mexico Study on Alcohol and Related Conditions, a cross-sectional survey of randomly se... | true | note_31 | note_31_ border population | 102 |
note_31_span_Mice_100000_150000_mid_mesh | BACKGROUND: | <unused6241> The U.S.-Mexico border displays elevated rates of hazardous alcohol and drug use. Whether the co-occurrence of alcohol and drug use and disorders is also high in the border area is unknown.METHODS: Data are from the U.S.-Mexico Study on Alcohol and Related Conditions, a cross-sectional survey of randomly s... | false | note_31 | note_31_BACKGROUND: | 103 |
note_31_span_Mice_100000_150000_mid_mesh | unknown.METHODS: | BACKGROUND: The U.S.-Mexico border displays elevated rates of hazardous alcohol and drug use. Whether the co-occurrence of alcohol and drug use and disorders is also high in the border area is<unused6241> Data are from the U.S.-Mexico Study on Alcohol and Related Conditions, a cross-sectional survey of randomly select... | true | note_31 | note_31_ unknown.METHODS: | 104 |
note_32_span_Signal Transduction_100000_150000_mid_mesh | anatomy, transcriptomic | BACKGROUND: Most studies of crop salinity tolerance are conducted under short-term stress condition within one growth stage. Understanding of the mechanisms of crop response to long-term salinity stress (LSS) is valuable for achieving the improvement of crop salinity tolerance. In the current study, we exposed allohexa... | false | note_32 | note_32_ anatomy, transcriptomic | 105 |
note_32_span_Signal Transduction_100000_150000_mid_mesh | plant hormones and | BACKGROUND: Most studies of crop salinity tolerance are conducted under short-term stress condition within one growth stage. Understanding of the mechanisms of crop response to long-term salinity stress (LSS) is valuable for achieving the improvement of crop salinity tolerance. In the current study, we exposed allohexa... | true | note_32 | note_32_ plant hormones and | 106 |
note_32_span_Signal Transduction_100000_150000_mid_mesh | (ABA) pathway and | BACKGROUND: Most studies of crop salinity tolerance are conducted under short-term stress condition within one growth stage. Understanding of the mechanisms of crop response to long-term salinity stress (LSS) is valuable for achieving the improvement of crop salinity tolerance. In the current study, we exposed allohexa... | true | note_32 | note_32_ (ABA) pathway and | 107 |
note_33_span_Cell Line, Tumor_100000_150000_mid_mesh | in mice. | 4-Phenylbutyric acid (4-PBA) has been used clinically to treat urea cycle disorders and is known to be an inhibitor of endoplasmic reticulum (ER) stress. We hypothesized that 4-PBA attenuates inflammatory bone loss by inducing autophagy, a process that is frequently accompanied by ER stress. Micro computerized tomograp... | false | note_33 | note_33_ in mice. | 108 |
note_34_span_Male_100000_150000_mid_mesh | Clinical Genetics, | STUDY QUESTION: Can of<unused6241> Maastricht University Medical Centre, Maastricht kisspeptin and its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved?SUMMARY ANSWER: Kisspeptin analogue-mediated cell motility in human decidual stromal cells via th... | false | note_34 | note_34_ Clinical Genetics, | 110 |
note_34_span_Male_100000_150000_mid_mesh | kisspeptin and | STUDY QUESTION: Can of Clinical Genetics, Maastricht University Medical Centre, Maastricht<unused6241> its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved?SUMMARY ANSWER: Kisspeptin analogue-mediated cell motility in human decidual stromal cells vi... | true | note_34 | note_34_ kisspeptin and | 111 |
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