spark_compound_id
stringlengths
11
11
spark_SMILES
stringlengths
13
285
spark_synonyms
stringclasses
44 values
spark_batch_name
int64
1
49
spark_compound_batch_id
stringlengths
15
15
compound_salt
stringclasses
19 values
source_compound_name
stringclasses
187 values
pubchem_id
float64
pubmed_id
float64
21.3M
30M
doi
stringclasses
12 values
source_compound_id
stringclasses
154 values
publication_date
stringdate
2018-09-28 00:00:00
2021-03-03 00:00:00
publication_reference
stringclasses
16 values
spark_mic_project_name
stringclasses
1 value
mic_micrograms_per_ml
stringlengths
1
10
mic_reported_as
stringclasses
4 values
test_article_type
stringclasses
2 values
mic_micromolar
stringlengths
1
9
mic_ineq_operator
stringclasses
3 values
plain_mic_micromolar
float64
0
576
plain_pmic
float64
3.24
9.06
pmic
float64
2.24
10.1
growth_inhibition_threshold
stringclasses
3 values
species
stringclasses
1 value
strain_name
stringclasses
5 values
strain_name_other
stringclasses
5 values
is_clinical_isolate
stringclasses
2 values
accumulation_phenotype
stringclasses
1 value
strain_genotype
stringclasses
2 values
solvent
stringclasses
3 values
media
stringclasses
7 values
mic_method
stringclasses
4 values
curator_notes
stringclasses
11 values
curation_date
stringdate
2018-09-06 00:00:00
2021-02-21 00:00:00
subset_date
stringdate
2020-04-09 00:00:00
2020-11-24 00:00:00
spark_extractor
stringclasses
3 values
full_strain_name
stringclasses
5 values
full_strain_name_with_genotype
stringclasses
5 values
id
stringlengths
12
12
smiles
stringlengths
11
275
inchikey
stringlengths
27
27
scaffold
stringlengths
5
143
mwt
float64
123
1.7k
clogp
float64
-6.74
7.49
tpsa
float64
3.24
697
is_train
bool
1 class
is_test
bool
1 class
is_validation
bool
1 class
SPK-0256346
CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCN(CC2)C(=O)CN)c(F)c1
null
1
SPK-0256346-001
No Salt, free base or acid
PMID:29554424 - Cmpd : 3
null
29,554,424
https://dx.doi.org/10.1021/acs.jmedchem.8b00218
3
17/02/2021
Liu 2018 J. Med. Chem. 61:3845
Curated Data
> 197
Mean
Test article
> 501
gt
501
3.300162
2.300162
Visual
Acinetobacter baumannii
ATCC 17978
5377; NCDC KC 755
No
Wild type
null
DMSO
MHBCa
CLSI
Table 1; JL
21/02/2021
18/11/2020
JL
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii ATCC 17978
SCB-59612255
CC(=O)NC[C@H]1CN(c2ccc(N3CCN(C(=O)CN)CC3)c(F)c2)C(=O)O1
PJXJVYZTQDPOHK-AWEZNQCLSA-N
O=C1OCCN1c1ccc(N2CCNCC2)cc1
393.181232
-0.1057
108.21
true
false
false
SPK-0256140
CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O)OC[C@]1(C)O
null
2
SPK-0256140-002
No Salt, free base or acid
PMID:26734854 - Cmpd : Gentamicin
null
26,734,854
https://dx.doi.org/10.1021/acs.jmedchem.5b01593
Gentamicin
13/02/2021
Gallardo-Godoy 2016 J. Med. Chem. 59:1068
Curated Data
32
MIC
Control / Reference compound
71.2
eq
71.2
4.14752
4.14752
Visual
Acinetobacter baumannii
ATCC 19606
CIP 70.34; DSM 6974; 2208; 81
Yes
Wild type
null
null
Not specified
CLSI broth microdilution
Table 2; JL
07/02/2021
07/11/2020
JL
Acinetobacter baumannii ATCC 19606
Acinetobacter baumannii ATCC 19606
SCB-12377987
CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O
VEGXETMJINRLTH-BOZYPMBZSA-N
C1CC[C@@H](O[C@@H]2CCC[C@H](O[C@@H]3CCCCO3)C2)OC1
449.284949
-3.9767
213.72
true
false
false
SPK-0256085
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
null
1
SPK-0256085-001
No Salt, free base or acid
PMID:21319749 - Cmpd : [Pro3]TL
null
21,319,749
https://dx.doi.org/10.1021/jm1012853
[Pro3]TL
03/03/2021
Mangoni 2011 J. Med. Chem. 54:1298
Curated Data
9.65
MIC
Test article
6
eq
6
5.221849
5.221849
spectrophotometer -100%
Acinetobacter baumannii
ATCC 19606
CIP 70.34; DSM 6974; 2208; 81
Yes
Wild type
null
Ethanol
MHB
Broth microdilution
Table 2; CH
03/01/2020
24/11/2020
JL
Acinetobacter baumannii ATCC 19606
Acinetobacter baumannii ATCC 19606
SCB-25776416
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
IHDIPKUESGTSEA-FOUPRROGSA-N
O=C(CCc1ccccc1)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCCc1ccccc1
1,607.93404
0.38517
533.46
true
false
false
SPK-0256084
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
null
1
SPK-0256084-001
No Salt, free base or acid
PMID:21319749 - Cmpd : TL
null
21,319,749
https://dx.doi.org/10.1021/jm1012853
TL
03/03/2021
Mangoni 2011 J. Med. Chem. 54:1298
Curated Data
9.84
MIC
Test article
6
eq
6
5.221849
5.221849
spectrophotometer -100%
Acinetobacter baumannii
ATCC 19606
CIP 70.34; DSM 6974; 2208; 81
Yes
Wild type
null
Ethanol
MHB
Broth microdilution
Table 2; CH
03/01/2020
24/11/2020
JL
Acinetobacter baumannii ATCC 19606
Acinetobacter baumannii ATCC 19606
SCB-38030918
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
SDXHFGQTTLDWPF-VTKIVCRMSA-N
O=C(CCc1ccccc1)NCC(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCCc1ccccc1
1,638.939853
-0.85553
585.34
true
false
false
SPK-0255611
COc1ccc2ncc(F)c(C[C@H](O)C34CCC(CC3)(CO4)NC(=O)c3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255611-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.82
eq
3.82
5.417937
5.417937
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11240595
COc1ccc2ncc(F)c(C[C@H](O)C34CCC(NC(=O)c5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
LWTMLUCOEAAVCY-RAYWSRASSA-N
O=C1COc2ccc(C(=O)NC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
523.186712
1.9186
144.79
true
false
false
SPK-0255602
CNC(=O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3cc4OCCOc4cn3)c2n1
null
1
SPK-0255602-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
32
MIC
Test article
59.5
eq
59.5
4.225483
4.225483
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-26746960
CNC(=O)COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6c(cn5)OCCO6)(CC3)CO4)c2n1
HQAQDKALACBCAU-UHFFFAOYSA-N
c1cnc2c(CCC34CCC(NCc5cc6c(cn5)OCCO6)(CC3)CO4)ccnc2c1
537.238747
2.8641
116.72
true
false
false
SPK-0255601
OCCNc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255601-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.65
eq
7.65
5.116339
5.116339
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-61427375
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(NCCO)nc56)(CC3)OC4)nc2N1
KEYFYLOJJBRLQT-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
522.239082
2.7032
130.52
true
false
false
SPK-0255594
CN(C)C(=O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255594-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
28.3
eq
28.3
4.548214
4.548214
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-49981817
CN(C)C(=O)COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
LIRNZJCTRSWRJY-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
564.249646
2.766
127.8
true
false
false
SPK-0255590
CNC(=O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255590-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.26
eq
7.26
5.139063
5.139063
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-62504766
CNC(=O)COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
MFNVOCAEZQBGRD-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
550.233996
2.4238
136.59
true
false
false
SPK-0255589
Fc1cnc2cccnc2c1CCC12CCC(CC1)(CO2)NCc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255589-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
1
MIC
Test article
2.16
eq
2.16
5.665546
5.665546
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-98077531
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6cccnc56)(CC3)OC4)nc2N1
RXTPXDFPFGCINK-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
463.201968
3.299
98.26
true
false
false
SPK-0255588
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4c(F)ccc(F)c4NC3=O)c2n1
null
1
SPK-0255588-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 8.00
MIC
Test article
> 15.3
gt
15.3
4.815309
3.815309
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-57524039
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6c(F)ccc(F)c6[nH]c5=O)(CC3)CO4)c2n1
IGGHXWYDVMDYND-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
524.203525
4.7014
89.13
true
false
false
SPK-0255586
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4c(F)ccc(F)c4N(C)C3=O)c2n1
null
1
SPK-0255586-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 2.00
MIC
Test article
> 3.71
gt
3.71
5.430626
4.430626
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-79693515
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6c(F)ccc(F)c6n(C)c5=O)(CC3)CO4)c2n1
GHEUSQFNMVKILT-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
538.219175
4.7118
78.27
true
false
false
SPK-0255584
FC(F)Oc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255584-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
0.5
MIC
Test article
0.944
eq
0.944
6.025028
6.025028
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-54980915
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OC(F)F)nc56)(CC3)OC4)nc2N1
OGRDPXKCFUNCDF-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
529.193689
3.9004
107.49
true
false
false
SPK-0255583
Fc1cnc2ccc(OCC3(CC3)C#N)nc2c1CCC12CCC(CC1)(CO2)NCc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255583-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.58
eq
3.58
5.446117
5.446117
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-33651072
N#CC1(COc2ccc3ncc(F)c(CCC45CCC(NCc6ccc7c(n6)NC(=O)CO7)(CC4)CO5)c3n2)CC1
HGPBSZHFLNTGOF-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
558.239082
3.98158
131.28
true
false
false
SPK-0255582
OC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255582-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 26.6
gt
26.6
4.575118
3.575118
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-49879929
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCC(F)(F)C(=O)O)nc56)(CC3)OC4)nc2N1
CSTGEWWOGMITFK-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
601.214818
3.7878
144.79
true
false
false
SPK-0255581
NC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255581-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
6.66
eq
6.66
5.176526
5.176526
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-18511155
NC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
ATPGZRKICBQLSQ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
600.230803
3.1885
150.58
true
false
false
SPK-0255580
CCOC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255580-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
32
MIC
Test article
50.8
eq
50.8
4.294136
4.294136
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-69918639
CCOC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
ONRUYAGLGNLXKI-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
629.246118
4.2663
133.79
true
false
false
SPK-0255579
COC(=O)C1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc4ccc5OCC(=O)Nc5n4)c3n2)CC1
null
1
SPK-0255579-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
13.5
eq
13.5
4.869666
4.869666
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-84458585
COC(=O)C1(COc2ccc3ncc(F)c(CCC45CCC(NCc6ccc7c(n6)NC(=O)CO7)(CC4)CO5)c3n2)CC1
SDQZRJQWIQHIKN-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
591.249312
3.631
133.79
true
false
false
SPK-0255577
OC(=O)c1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255577-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 31.5
gt
31.5
4.501689
3.501689
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-61758241
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(C(=O)O)nc56)(CC3)OC4)nc2N1
HEPXUQJKKPZPPU-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
507.191797
2.9972
135.56
true
false
false
SPK-0255576
COC(=O)c1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255576-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.83
eq
3.83
5.416801
5.416801
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-88753712
COC(=O)c1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
GUTOCTQLMMUUBN-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
521.207447
3.0856
124.56
true
false
false
SPK-0255574
OC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255574-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
27.6
eq
27.6
4.559091
4.559091
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-32794111
O=C(O)CCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
LLQTWPUPOTXGPN-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
579.249312
3.9327
144.79
true
false
false
SPK-0255573
COC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255573-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 4.00
MIC
Test article
> 6.74
gt
6.74
5.17134
4.17134
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10974763
COC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
FBXMQLGXPQSALD-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
593.264962
4.0211
133.79
true
false
false
SPK-0255571
CCOC(=O)CCCOc1ccc2ncc(C#N)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255571-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
13.3
eq
13.3
4.876148
4.876148
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-43827629
CCOC(=O)CCCOc1ccc2ncc(C#N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
RXVBGRPDXDPPDO-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
600.269633
3.75368
157.58
true
false
false
SPK-0255570
Fc1cnc2ccc(OCCCC#N)nc2c1CCC12CCC(CC1)(CO2)NCc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255570-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.66
eq
3.66
5.436519
5.436519
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-63182356
N#CCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
RGHWQSMOWWEXGJ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
546.239082
3.98158
131.28
true
false
false
SPK-0255569
NC1CC1COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255569-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
0.25
MIC
Test article
0.456
eq
0.456
6.341035
6.341035
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-59588935
NC1CC1COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
UQVNDLXCWMYEIP-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
548.254732
3.025
133.51
true
false
false
SPK-0255567
CCOC(=O)CCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255567-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.37
eq
3.37
5.47237
5.47237
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-77581469
CCOC(=O)CCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
AUMKIRNMXZPPIG-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
593.264962
4.0211
133.79
true
false
false
SPK-0255562
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4cccc(Cl)c4N(C)C3=O)c2n1
null
1
SPK-0255562-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 2.00
MIC
Test article
> 3.72
gt
3.72
5.429457
4.429457
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-99920373
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6cccc(Cl)c6n(C)c5=O)(CC3)CO4)c2n1
DQGMFUNAZSRXOR-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
536.199047
5.087
78.27
true
false
false
SPK-0255559
Oc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255559-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
4.17
eq
4.17
5.379864
5.379864
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11108295
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(O)nc56)(CC3)OC4)nc2N1
MBHXCYHYWQPDMS-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
479.196883
3.0046
118.49
true
false
false
SPK-0255554
[NH3+]CC(O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255554-001
2.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
32
MIC
Test article
51.2
eq
51.2
4.29073
4.29073
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11537057
[NH3+]CC(O)COc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
DFTZBCABZMFRQY-UHFFFAOYSA-P
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
554.264199
0.2544
159.94
true
false
false
SPK-0255551
OCCOc1ccc2ncc(F)c(CC(O)C34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255551-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.47
eq
3.47
5.459671
5.459671
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-67688175
O=C1COc2ccc(C[NH2+]C34CCC(C(O)Cc5c(F)cnc6ccc(OCCO)nc56)(CC3)OC4)nc2N1
RAABKQRUDXNJMT-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
540.225288
0.6147
152.53
true
false
false
SPK-0255548
COc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c(F)cnc2cc1F
null
1
SPK-0255548-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
1
MIC
Test article
1.82
eq
1.82
5.739929
5.739929
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-73560712
COc1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2cc1F
XCSMKROOVVFXNT-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
512.210387
2.4205
112.07
true
false
false
SPK-0255547
CC(C)(O)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255547-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
26.6
eq
26.6
4.575118
4.575118
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-46822228
CC(C)(O)CCOc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
GBOBHDKFANTRAN-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
566.277324
2.8126
132.3
true
false
false
SPK-0255543
CC(O)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255543-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
27.2
eq
27.2
4.565431
4.565431
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-96942285
CC(O)CCOc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
CPALNVBUAXEUEA-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
552.261674
2.4225
132.3
true
false
false
SPK-0255537
OCCCOc1ccc2ncc(F)c(CC(O)C34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255537-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.39
eq
3.39
5.4698
5.4698
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11327027
O=C1COc2ccc(C[NH2+]C34CCC(C(O)Cc5c(F)cnc6ccc(OCCCO)nc56)(CC3)OC4)nc2N1
GOSJYGIGXHPKNH-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
554.240938
1.0048
152.53
true
false
false
SPK-0255536
Fc1cnc2ccc(OCC=C)nc2c1CCC12CCC(CC1)(CO2)[NH2+]Cc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255536-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.6
eq
3.6
5.443697
5.443697
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-20472343
C=CCOc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
UOTDABQSENKCSO-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
520.235459
2.8376
112.07
true
false
false
SPK-0255535
Fc1cnc2ccc(OCC(F)(F)F)nc2c1CCC12CCC(CC1)(CO2)[NH2+]Cc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255535-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
13.4
eq
13.4
4.872895
4.872895
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-63967704
O=C1COc2ccc(C[NH2+]C34CCC(CCc5c(F)cnc6ccc(OCC(F)(F)F)nc56)(CC3)OC4)nc2N1
FNMQWAJVVVNDOF-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
562.207194
3.2139
112.07
true
false
false
SPK-0255534
CC(O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255534-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.48
eq
3.48
5.458421
5.458421
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-96083271
CC(O)COc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
FLQUYKJMJBBQNI-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
538.246024
2.0324
132.3
true
false
false
SPK-0255531
OCC(O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255531-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
6.78
eq
6.78
5.16877
5.16877
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10070340
O=C1COc2ccc(C[NH2+]C34CCC(CCc5c(F)cnc6ccc(OCC(O)CO)nc56)(CC3)OC4)nc2N1
ITDGSGSKYMTULC-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
554.240938
1.0048
152.53
true
false
false
SPK-0255529
NC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc4ccc5OCC(=O)Nc5n4)c3n2)CC1
null
1
SPK-0255529-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
1
MIC
Test article
1.82
eq
1.82
5.739929
5.739929
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-33959564
NC1(COc2ccc3ncc(F)c(CCC45CCC(NCc6ccc7c(n6)NC(=O)CO7)(CC4)CO5)c3n2)CC1
BLMUTZYJPAPONW-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
548.254732
3.1691
133.51
true
false
false
SPK-0255528
O=C1COc2ccc(CNC34CCC(CCc5c(cnc6ccc(nc56)C#N)C#N)(CC3)OC4)nc2N1
null
1
SPK-0255528-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
4.04
eq
4.04
5.393619
5.393619
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11089154
N#Cc1ccc2ncc(C#N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
JIQBBLTUYJYCFO-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
495.201888
2.90326
145.84
true
false
false
SPK-0255526
OCCOCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255526-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
26.5
eq
26.5
4.576754
4.576754
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-69355229
O=C1COc2ccc(C[NH2+]C34CCC(CCc5c(F)cnc6ccc(OCCOCCO)nc56)(CC3)OC4)nc2N1
DBSWTWPDQCRYPY-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
568.256588
1.6605
141.53
true
false
false
SPK-0255525
CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255525-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.68
eq
3.68
5.434152
5.434152
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10004974
CCOc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
UCFIRUNAQQQREZ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
508.235459
2.6715
112.07
true
false
false
SPK-0255524
CC(C)Oc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255524-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.3
eq
14.3
4.844664
4.844664
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-55826022
CC(C)Oc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
GRICKAAZQBDHJM-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
522.251109
3.06
112.07
true
false
false
SPK-0255522
OCCCOc1ccc2ncc(C#N)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255522-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.34
eq
7.34
5.134304
5.134304
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11423764
N#Cc1cnc2ccc(OCCCO)nc2c1CCC12CCC(NCc3ccc4c(n3)NC(=O)CO4)(CC1)CO2
MURXRTWXVGTFOZ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
544.243418
2.79278
151.51
true
false
false
SPK-0255521
OCCOc1ccc2ncc(C#N)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255521-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.77
eq
3.77
5.423659
5.423659
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-30014763
N#Cc1cnc2ccc(OCCO)nc2c1CCC12CCC(NCc3ccc4c(n3)NC(=O)CO4)(CC1)CO2
KPCUSHHKTYZSMW-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
530.227768
2.40268
151.51
true
false
false
SPK-0255519
COc1ccc2nc(OC)cc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255519-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 8.00
MIC
Test article
> 14.8
gt
14.8
4.829738
3.829738
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-52376679
COc1cc(CCC23CCC([NH2+]Cc4ccc5c(n4)NC(=O)CO5)(CC2)CO3)c2nc(OC)ccc2n1
VXWNCQDVTWJQBA-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
506.239796
2.1509
121.3
true
false
false
SPK-0255518
COc1ccc2ncc(F)c(CC(NC(C)=O)C34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255518-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 32.0
MIC
Test article
> 54.5
gt
54.5
4.263603
3.263603
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-75318117
COc1ccc2ncc(F)c(CC(NC(C)=O)C34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
TVDCOCAXRLASBO-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
551.241273
1.396
141.17
true
false
false
SPK-0255515
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4c(Cl)cccc4N(C)C3=O)c2n1
null
1
SPK-0255515-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 32.0
MIC
Test article
> 59.6
gt
59.6
4.224754
3.224754
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-57672331
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6c(Cl)cccc6n(C)c5=O)(CC3)CO4)c2n1
WTRPASPANYIXJV-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
536.199047
5.087
78.27
true
false
false
SPK-0255513
COc1ccc2C=C(CNC34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4)C(=O)N(C)c2c1
null
1
SPK-0255513-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 30.0
gt
30
4.522879
3.522879
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-88649607
COc1ccc2cc(CNC34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4)c(=O)n(C)c2c1
XJTDDPNTTITVDJ-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
532.248584
4.4422
87.5
true
false
false
SPK-0255512
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4ccc(F)cc4N(C)C3=O)c2n1
null
1
SPK-0255512-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 4.00
MIC
Test article
> 7.68
gt
7.68
5.114639
4.114639
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11333188
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6ccc(F)cc6n(C)c5=O)(CC3)CO4)c2n1
FPHDVYQUXJCYAY-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
520.228597
4.5727
78.27
true
false
false
SPK-0255509
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4ccc(Cl)cc4N(C)C3=O)c2n1
null
1
SPK-0255509-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 8.00
MIC
Test article
> 14.9
gt
14.9
4.826814
3.826814
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-78036823
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6ccc(Cl)cc6n(C)c5=O)(CC3)CO4)c2n1
MNCJOYYTUKGSFH-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
536.199047
5.087
78.27
true
false
false
SPK-0255508
COC1=C(CNC23CCC(CCc4c(F)cnc5ccc(OC)nc45)(CC2)OC3)C(=O)N(C)c2ccccc12
null
1
SPK-0255508-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 32.0
MIC
Test article
> 60.1
gt
60.1
4.221126
3.221126
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-36865835
COc1ccc2ncc(F)c(CCC34CCC(NCc5c(OC)c6ccccc6n(C)c5=O)(CC3)CO4)c2n1
JDVRZTZVDBSJJI-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
532.248584
4.4422
87.5
true
false
false
SPK-0255507
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4cc(OC)c(OC)cc4N(C)C3=O)c2n1
null
1
SPK-0255507-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 28.4
gt
28.4
4.546682
3.546682
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-71757038
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6cc(OC)c(OC)cc6n(C)c5=O)(CC3)CO4)c2n1
DECLRTJPNZAGHK-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
562.259148
4.4508
96.73
true
false
false
SPK-0255506
COc1ccc2N(C)C(=O)C(CNC34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4)=Cc2c1
null
1
SPK-0255506-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 30.0
gt
30
4.522879
3.522879
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-16998572
COc1ccc2c(c1)cc(CNC13CCC(CCc4c(F)cnc5ccc(OC)nc45)(CC1)OC3)c(=O)n2C
ADGZRQTXLMWFPQ-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
532.248584
4.4422
87.5
true
false
false
SPK-0255505
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4cc(Cl)ccc4N(C)C3=O)c2n1
null
1
SPK-0255505-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 29.8
gt
29.8
4.525784
3.525784
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-17875020
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6cc(Cl)ccc6n(C)c5=O)(CC3)CO4)c2n1
DRCBXROKLHDQHT-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
536.199047
5.087
78.27
true
false
false
SPK-0255504
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCC3=Cc4cc(F)ccc4N(C)C3=O)c2n1
null
1
SPK-0255504-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 30.7
gt
30.7
4.512862
3.512862
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-74914512
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc6cc(F)ccc6n(C)c5=O)(CC3)CO4)c2n1
PINNVXUJPWDKLA-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
520.228597
4.5727
78.27
true
false
false
SPK-0255503
NCC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc4ccc5OCC(=O)Nc5n4)c3n2)CC1
null
1
SPK-0255503-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.11
eq
7.11
5.14813
5.14813
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-86096172
NCC1(COc2ccc3ncc(F)c(CCC45CCC(NCc6ccc7c(n6)NC(=O)CO7)(CC4)CO5)c3n2)CC1
DZQFDSBQRPUTFZ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
562.270382
3.4167
133.51
true
false
false
SPK-0255497
COc1cc(OC)c2nccc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255497-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.8
eq
14.8
4.829738
4.829738
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10812320
COc1cc(OC)c2nccc(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
UTLHZBPHIKAJMV-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
506.239796
2.1509
121.3
true
false
false
SPK-0255492
OCC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc4ccc5OCC(=O)Nc5n4)c3n2)CC1
null
1
SPK-0255492-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.1
eq
7.1
5.148742
5.148742
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10305340
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCC7(CO)CC7)nc56)(CC3)OC4)nc2N1
LDCYXCYVKCIBDF-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(OCC7CC7)nc56)(CC3)OC4)nc2N1
563.254397
3.4503
127.72
true
false
false
SPK-0255490
COc1ccc2ncc(F)c(CC(O)C34CCC(CC3)(CO4)[NH2+]Cc3nc4NC(=O)COc4cc3OC)c2n1
null
1
SPK-0255490-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
27.8
eq
27.8
4.555955
4.555955
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-41407389
COc1ccc2ncc(F)c(CC(O)C34CCC([NH2+]Cc5nc6c(cc5OC)OCC(=O)N6)(CC3)CO4)c2n1
XIKSGTWGUXYRSH-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
540.225288
1.2608
141.53
true
false
false
SPK-0255489
Nc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255489-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
4.18
eq
4.18
5.378824
5.378824
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-11282431
Nc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
JEVFHPJPDIVJFF-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
478.212867
2.8812
124.28
true
false
false
SPK-0255488
COC(Cc1c(F)cnc2ccc(OC)nc12)C12CCC(CC1)(CO2)[NH2+]Cc1ccc2OCC(=O)Nc2n1
null
1
SPK-0255488-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.3
eq
14.3
4.844664
4.844664
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-59739134
COc1ccc2ncc(F)c(CC(OC)C34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
QPSASROYWRAKFK-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
524.230374
1.9063
121.3
true
false
false
SPK-0255487
NCCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255487-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.08
eq
7.08
5.149967
5.149967
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-87692774
NCCCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
VUFOAJNCCLDYIJ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
564.286032
3.8068
133.51
true
false
false
SPK-0255486
Fc1cnc2ccc(nc2c1CCC12CCC(CC1)(CO2)NCc1ccc2OCC(=O)Nc2n1)C#N
null
1
SPK-0255486-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
1
MIC
Test article
2.05
eq
2.05
5.688246
5.688246
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-28327095
N#Cc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
ILFLTPHJLYDKRC-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
488.197217
3.17068
122.05
true
false
false
SPK-0255485
COc1ccc2ncc(F)c(CC(O)C34CCC(CC3)(CO4)NCC3=Cc4ccccc4N(C)C3=O)c2n1
null
1
SPK-0255485-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
64
MIC
Test article
123
eq
123
3.910095
3.910095
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-98116489
COc1ccc2ncc(F)c(CC(O)C34CCC(NCc5cc6ccccc6n(C)c5=O)(CC3)CO4)c2n1
CRZAOYCLXXPJRM-UHFFFAOYSA-N
O=c1[nH]c2ccccc2cc1CNC12CCC(CCc3ccnc4cccnc34)(CC1)OC2
518.232934
3.4044
98.5
true
false
false
SPK-0255484
CN(C)c1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255484-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
15.8
eq
15.8
4.801343
4.801343
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-84710298
CN(C)c1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
HYGNCGIVYDCLDT-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
506.244167
3.365
101.5
true
false
false
SPK-0255482
COc1ccc2ncc(F)c(CC(O)C34CCC(CC3)(CO4)NCc3cc4OCCOc4cn3)c2n1
null
1
SPK-0255482-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
4.03
eq
4.03
5.394695
5.394695
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-25838441
COc1ccc2ncc(F)c(CC(O)C34CCC(NCc5cc6c(cn5)OCCO6)(CC3)CO4)c2n1
OLOZPSRCROBHRI-UHFFFAOYSA-N
c1cnc2c(CCC34CCC(NCc5cc6c(cn5)OCCO6)(CC3)CO4)ccnc2c1
496.212198
2.7187
107.85
true
false
false
SPK-0255481
NCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255481-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.5
eq
14.5
4.838632
4.838632
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-68474329
NCCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
PPLZYPDLRUCVGQ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
550.270382
3.4167
133.51
true
false
false
SPK-0255480
OCCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255480-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.1
eq
14.1
4.850781
4.850781
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-89121991
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCCCCO)nc56)(CC3)OC4)nc2N1
ATODYUVMSIEGRJ-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
565.270047
3.8404
127.72
true
false
false
SPK-0255478
COc1cc2nccc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2nc1C(O)=O
null
1
SPK-0255478-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 28.8
gt
28.8
4.540608
3.540608
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10578168
COc1cc2nccc(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1C(=O)O
YUGWXMFOVWSSAF-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
520.21906
1.8405
149.37
true
false
false
SPK-0255476
COc1cc2nccc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2nc1C#N
null
1
SPK-0255476-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
32
MIC
Test article
59.6
eq
59.6
4.224754
4.224754
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-20867546
COc1cc2nccc(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1C#N
BFVYILGFEODFHY-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
501.22448
2.01398
135.86
true
false
false
SPK-0255475
Cc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255475-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.89
eq
3.89
5.41005
5.41005
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-21118408
Cc1ccc2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
HMKRKNIGUHIIBQ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
478.224894
2.58122
102.84
true
false
false
SPK-0255474
Fc1cnc2cc(cnc2c1CCC12CCC(CC1)(CO2)[NH2+]Cc1ccc2OCC(=O)Nc2n1)C(F)(F)F
null
1
SPK-0255474-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 28.2
gt
28.2
4.549751
3.549751
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-53172460
O=C1COc2ccc(C[NH2+]C34CCC(CCc5c(F)cnc6cc(C(F)(F)F)cnc56)(CC3)OC4)nc2N1
CTNBGVIPBVIIHQ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
532.196629
3.2916
102.84
true
false
false
SPK-0255473
OCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255473-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.63
eq
3.63
5.440093
5.440093
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-99025572
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCCCO)nc56)(CC3)OC4)nc2N1
GXTVQPOIAIZQBV-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
551.254397
3.4503
127.72
true
false
false
SPK-0255470
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc(OC(F)F)c(OC)c3)c2n1
null
1
SPK-0255470-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 4.00
MIC
Test article
> 7.73
gt
7.73
5.111821
4.111821
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-57791054
COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc(OC(F)F)c(OC)c5)(CC3)CO4)c2n1
XFWBLGYLKSUBSQ-UHFFFAOYSA-N
c1ccc(CNC23CCC(CCc4ccnc5cccnc45)(CC2)OC3)cc1
517.218841
5.1917
74.73
true
false
false
SPK-0255463
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3cc(Cl)c(O)c(OC)c3)c2n1
null
1
SPK-0255463-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 31.9
gt
31.9
4.496209
3.496209
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-25307178
COc1ccc2ncc(F)c(CCC34CCC(NCc5cc(Cl)c(O)c(OC)c5)(CC3)CO4)c2n1
GIELLNZZPXTNOZ-UHFFFAOYSA-N
c1ccc(CNC23CCC(CCc4ccnc5cccnc45)(CC2)OC3)cc1
501.183062
4.9493
85.73
true
false
false
SPK-0255462
COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc(OCCO)c(OC)c3)c2n1
null
1
SPK-0255462-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 32.0
MIC
Test article
> 62.5
gt
62.5
4.20412
3.20412
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-83464682
COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc(OCCO)c(OC)c5)(CC3)CO4)c2n1
FAJSPCYINJCLGJ-UHFFFAOYSA-N
c1ccc(CNC23CCC(CCc4ccnc5cccnc45)(CC2)OC3)cc1
511.248249
3.9614
94.96
true
false
false
SPK-0255459
COc1ccc2ncc(C#N)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255459-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
1
MIC
Test article
2
eq
2
5.69897
5.69897
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-76563004
COc1ccc2ncc(C#N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
WCYXNADXJFLPLU-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
500.217203
3.04018
131.28
true
false
false
SPK-0255458
NCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255458-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.73
eq
3.73
5.428291
5.428291
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10434514
NCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
UZTUCRSUEBSPQL-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
536.254732
3.0266
133.51
true
false
false
SPK-0255457
OCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255457-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.72
eq
3.72
5.429457
5.429457
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-79629908
O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCCO)nc56)(CC3)OC4)nc2N1
DDGUECXQOLRLTK-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
537.238747
3.0602
127.72
true
false
false
SPK-0255456
Cc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1C#N
null
1
SPK-0255456-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 30.7
gt
30.7
4.512862
3.512862
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-73555124
Cc1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C#N
NGNXHJDLPHMLFY-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
485.229565
2.3138
126.63
true
false
false
SPK-0255455
COc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1C#N
null
1
SPK-0255455-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
64
MIC
Test article
119
eq
119
3.924453
3.924453
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-50554491
COc1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C#N
JJAVZBMRFRBWDW-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
501.22448
2.01398
135.86
true
false
false
SPK-0255454
Cc1cc(nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc12)C#N
null
1
SPK-0255454-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.68
eq
7.68
5.114639
5.114639
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-77757620
Cc1cc(C#N)nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12
DRSVXWHVRMRVHN-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
485.229565
2.3138
126.63
true
false
false
SPK-0255453
CN(C)c1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1F
null
1
SPK-0255453-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
29.5
eq
29.5
4.530178
4.530178
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-29772617
CN(C)c1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1F
VDRAVYVWNMRWRJ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
507.251444
2.3388
106.08
true
false
false
SPK-0255452
FC(F)(F)c1cnc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2c1
null
1
SPK-0255452-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 64.0
MIC
Test article
> 116
gt
116
3.935542
2.935542
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-62783869
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cc(C(F)(F)F)cnc56)(CC3)OC4)nc2N1
DUYSYYLKFVSLPK-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
514.206051
3.1525
102.84
true
false
false
SPK-0255451
CCOC(=O)Cc1ccc2nccc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255451-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
64
MIC
Test article
113
eq
113
3.946922
3.946922
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-86600149
CCOC(=O)Cc1ccc2nccc(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
WGDSYECIVVZAFS-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
532.255446
2.2393
129.14
true
false
false
SPK-0255448
CN(C)c1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c(F)cnc2cc1C(F)(F)F
null
1
SPK-0255448-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 8.00
MIC
Test article
> 13.1
gt
13.1
4.882729
3.882729
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-88983653
CN(C)c1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2cc1C(F)(F)F
NXYIXANPOKONHP-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
575.238828
3.3576
106.08
true
false
false
SPK-0255447
COc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c(F)cnc2cc1Cl
null
1
SPK-0255447-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.09
eq
7.09
5.149354
5.149354
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-57281533
COc1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2cc1Cl
BDZIINJGNHDBJN-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
528.180837
2.9348
112.07
true
false
false
SPK-0255446
Fc1cnc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2c1
null
1
SPK-0255446-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
32
eq
32
4.49485
4.49485
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-64388569
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cc(F)cnc56)(CC3)OC4)nc2N1
PBBOZWAACFELNZ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
464.209244
2.2728
102.84
true
false
false
SPK-0255445
CCOC(=O)c1c(OC)cnc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc12
null
1
SPK-0255445-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 27.4
gt
27.4
4.562249
3.562249
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-39006481
CCOC(=O)c1c(OC)cnc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12
LXYNMZQDPFEWFU-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
548.25036
2.319
138.37
true
false
false
SPK-0255444
COc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1F
null
1
SPK-0255444-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.77
eq
3.77
5.423659
5.423659
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-58079348
COc1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1F
NACWNTSDETVYGS-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
494.219809
2.2814
112.07
true
false
false
SPK-0255443
CCOc1cc(C)c2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255443-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
4
MIC
Test article
7.17
eq
7.17
5.144481
5.144481
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-21790556
CCOc1cc(C)c2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
OZMIGRXTWZPPDK-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
522.251109
2.97992
112.07
true
false
false
SPK-0255442
Cc1cc(nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c(F)cnc12)S(C)(=O)=O
null
1
SPK-0255442-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.38
eq
3.38
5.471083
5.471083
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-33716048
Cc1cc(S(C)(=O)=O)nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc12
RDBDMDKGHUCBKR-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
556.202445
1.98472
136.98
true
false
false
SPK-0255441
CN(C)c1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1C(F)(F)F
null
1
SPK-0255441-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 8.00
MIC
Test article
> 13.5
gt
13.5
4.869666
3.869666
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-87954780
CN(C)c1nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C(F)(F)F
ZJDAPEQJSXHCSQ-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
557.24825
3.2185
106.08
true
false
false
SPK-0255440
FC(F)(F)c1ccc2nccc(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255440-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
8
MIC
Test article
14.5
eq
14.5
4.838632
4.838632
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10308219
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6ccc(C(F)(F)F)nc56)(CC3)OC4)nc2N1
KLQSQCOFPGFUBN-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
514.206051
3.1525
102.84
true
false
false
SPK-0255439
Cc1cc(nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc12)S(C)(=O)=O
null
1
SPK-0255439-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
16
MIC
Test article
27.9
eq
27.9
4.554396
4.554396
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-10675786
Cc1cc(S(C)(=O)=O)nc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12
PTFLGBBOPKLEKM-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
538.211867
1.84562
136.98
true
false
false
SPK-0255438
FC(F)(F)COc1nc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2cc1C#N
null
1
SPK-0255438-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 64.0
MIC
Test article
> 106
gt
106
3.974694
2.974694
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-91186489
N#Cc1cc2nccc(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1OCC(F)(F)F
PKMRPCGPUIPGMM-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
569.211864
2.94648
135.86
true
false
false
SPK-0255437
CN(C)c1cnc2c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)ccnc2c1
null
1
SPK-0255437-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
> 16.0
MIC
Test article
> 30.5
gt
30.5
4.5157
3.5157
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-65043216
CN(C)c1cnc2c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2c1
LQOQCSXTRUOHTE-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
489.260865
2.1997
106.08
true
false
false
SPK-0255436
COc1cc(C)c2ncc(F)c(CCC34CCC(CC3)(CO4)[NH2+]Cc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255436-001
1.0 Hydrochloride
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
3.68
eq
3.68
5.434152
5.434152
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-41079999
COc1cc(C)c2ncc(F)c(CCC34CCC([NH2+]Cc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
ZBAGPAIAXPURHB-UHFFFAOYSA-O
O=C1COc2ccc(C[NH2+]C34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
508.235459
2.58982
112.07
true
false
false
SPK-0255432
COc1ccc2ncc(O)c(CCC34CCC(CC3)(CO4)NCc3ccc4OCC(=O)Nc4n3)c2n1
null
1
SPK-0255432-001
No Salt, free base or acid
null
null
null
null
null
18/11/2020
Merck & Kyorin - GyrAB/ParCE inhibitors
Curated Data
2
MIC
Test article
4.07
eq
4.07
5.390406
5.390406
Visual
Acinetobacter baumannii
IID876
null
No
Wild type
Wild type
DMSO
CAMHB
CLSI broth microdilution
TKW
06/11/2020
null
null
Acinetobacter baumannii IID876
Acinetobacter baumannii IID876 Wild type
SCB-59761543
COc1ccc2ncc(O)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1
IJHGKXUQHWKCCE-UHFFFAOYSA-N
O=C1COc2ccc(CNC34CCC(CCc5ccnc6cccnc56)(CC3)OC4)nc2N1
491.216869
2.8741
127.72
true
false
false