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parahippocampus.","text_display":" regions including the amygdala, hippocampus, entorhinal cortex, and parahippocampus.","confidence":1,"confidence_rate":1},{"cnt":[[331,503],[1848,503],[1848,552],[331,552]],"region":{"top_left_x":330,"top_left_y":502,"width":1518,"height":51},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f23f6ed384d04886a5ca2f58421787f3","type":"text","conversion_output":true,"text":"- \\({ }^{ 1 8 F }\\) MK-6240 PET SUVR (Global Mean): SUVR global mean normalized to cerebellar","text_display":"\n- \\({ }^{ 1 8 F }\\) MK-6240 PET SUVR (Global Mean): SUVR global mean normalized to 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For \\(n =120\\), the minimum detectable effect size increased slightly to a Cohen's","text_display":" funding timeline. 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There was no adjustment for multiple statistical comparisons in this trial.","confidence":0.99560546875,"confidence_rate":0.9999576526698952},{"cnt":[[249,1693],[883,1693],[883,1738],[249,1738]],"region":{"top_left_x":249,"top_left_y":1692,"width":635,"height":47},"line":28,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bc282daaf6a84849b5ec441f35bbff84","type":"text","conversion_output":true,"text":"All analyses were conducted using R.","text_display":" All analyses were conducted using R.","confidence":0.99755859375,"confidence_rate":0.9999403824761762},{"cnt":[[249,1830],[1777,1830],[1777,1876],[249,1876]],"region":{"top_left_x":249,"top_left_y":1830,"width":1528,"height":46},"line":29,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"b8932b109f6844079764b0e8f19d1ad3","type":"text","conversion_output":true,"text":"We first examined patients' baseline characteristics to ensure that covariates were balanced","text_display":"\n\nWe first examined patients' baseline characteristics to ensure that covariates were balanced","confidence":0.99951171875,"confidence_rate":0.9999949649559944},{"cnt":[[249,1878],[1833,1878],[1833,1923],[249,1923]],"region":{"top_left_x":249,"top_left_y":1877,"width":1584,"height":46},"line":30,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"57a781f1639b47e08fa50f4a892b9596","type":"text","conversion_output":true,"text":"between treatment and placebo arms. 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( \\(\\beta_{0}, \\beta_{1}, \\alpha , \\gamma , \\delta\\) ) are fixed effects parameters. The efficacy of Valacyclovir","text_display":"\nresidual error term. ( \\(\\beta_{0}, \\beta_{1}, \\alpha , \\gamma , \\delta\\) ) are fixed effects parameters. The efficacy of Valacyclovir","confidence":0.979520550230518,"confidence_rate":0.9998317860073621},{"cnt":[[247,305],[1871,305],[1871,354],[247,354]],"region":{"top_left_x":247,"top_left_y":305,"width":1625,"height":50},"line":2,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"5877f65888084aa68c55f737aa890f7d","type":"text","conversion_output":true,"text":"versus placebo at each time point was tested by forming contrasts of the fitted model. The model","text_display":" versus placebo at each time point was tested by forming contrasts of the fitted model. The model","confidence":1,"confidence_rate":1},{"cnt":[[247,352],[1723,352],[1723,402],[247,402]],"region":{"top_left_x":247,"top_left_y":352,"width":1477,"height":50},"line":3,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"524edc9670354944a4a52a5d4f8177b0","type":"text","conversion_output":true,"text":"was further adjusted for key demographic and genetic variables, including age, sex, and","text_display":" was further adjusted for key demographic and genetic variables, including age, sex, and","confidence":1,"confidence_rate":1},{"cnt":[[249,400],[1833,400],[1833,449],[249,449]],"region":{"top_left_x":249,"top_left_y":399,"width":1584,"height":51},"line":4,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"2e8d4bc938d7442fb170a630e46f077a","type":"text","conversion_output":true,"text":"apolipoprotein E c4 carrier status. Missing data on outcome variables were dealt with by using","text_display":" apolipoprotein E c4 carrier status. Missing data on outcome variables were dealt with by using","confidence":0.8577557702083141,"confidence_rate":0.9984513431345955},{"cnt":[[249,449],[1835,449],[1835,501],[249,501]],"region":{"top_left_x":249,"top_left_y":449,"width":1586,"height":52},"line":5,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f0f1c99cb2344a3aad8320d32be5fa25","type":"text","conversion_output":true,"text":"(longitudinal) linear mixed effects models which do not require complete measurements under","text_display":" (longitudinal) linear mixed effects models which do not require complete measurements under","confidence":1,"confidence_rate":1},{"cnt":[[249,498],[874,498],[874,548],[249,548]],"region":{"top_left_x":249,"top_left_y":498,"width":626,"height":50},"line":6,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"69c528b9be7f48d3bde66624f5e35b56","type":"text","conversion_output":true,"text":"the \"missing at random\" assumption.","text_display":" the \"missing at random\" assumption.","confidence":1,"confidence_rate":1},{"cnt":[[247,632],[1798,632],[1798,683],[247,683]],"region":{"top_left_x":247,"top_left_y":631,"width":1552,"height":53},"line":7,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d83cb4e771454d8fa91309692bbf89eb","type":"text","conversion_output":true,"text":"For the primary outcome (ADAS-Cog 11), a series of sensitivity analyses were conducted to","text_display":"\n\nFor the primary outcome (ADAS-Cog 11), a series of sensitivity analyses were conducted to","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[249,681],[1871,681],[1871,733],[249,733]],"region":{"top_left_x":249,"top_left_y":681,"width":1623,"height":52},"line":8,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"eb35858c6a534692b1031eb025361bf7","type":"text","conversion_output":true,"text":"evaluate the robustness of the findings across key clinical subgroups and under different analytic","text_display":" evaluate the robustness of the findings across key clinical subgroups and under different analytic","confidence":1,"confidence_rate":1},{"cnt":[[249,730],[1828,730],[1828,780],[249,780]],"region":{"top_left_x":249,"top_left_y":730,"width":1580,"height":50},"line":9,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"6a7c0c497a714b239806da6789c802f4","type":"text","conversion_output":true,"text":"assumptions. These included: 1) a per-protocol analysis limited to participants who completed","text_display":" assumptions. These included: 1) a per-protocol analysis limited to participants who completed","confidence":1,"confidence_rate":1},{"cnt":[[249,778],[1755,778],[1755,827],[249,827]],"region":{"top_left_x":249,"top_left_y":777,"width":1507,"height":51},"line":10,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"de13355bccc24a8e9e8b061de1be1c3e","type":"text","conversion_output":true,"text":"the study; 2) a subgroup analysis of participants who received cholinesterase inhibitors or","text_display":" the study; 2) a subgroup analysis of participants who received cholinesterase inhibitors or","confidence":1,"confidence_rate":1},{"cnt":[[249,825],[1781,825],[1781,879],[249,879]],"region":{"top_left_x":249,"top_left_y":825,"width":1533,"height":54},"line":11,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d9507fc88602431ea2d8101e4399ca65","type":"text","conversion_output":true,"text":"memantine; and 3) a subgroup analysis of participants with a baseline 18F-Florbetapir PET","text_display":" memantine; and 3) a subgroup analysis of participants with a baseline 18F-Florbetapir PET","confidence":0.99951171875,"confidence_rate":0.999994804263518},{"cnt":[[249,872],[941,872],[941,924],[249,924]],"region":{"top_left_x":249,"top_left_y":872,"width":693,"height":52},"line":12,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"cd592ee353e642ac982e95605f1b4093","type":"text","conversion_output":true,"text":"SUVR \\(\\geq 1.15\\) (amyloid positive for AD).","text_display":" SUVR \\(\\geq 1.15\\) (amyloid positive for AD).","confidence":0.99951171875,"confidence_rate":0.9999891467144949},{"cnt":[[249,1010],[1846,1010],[1846,1059],[249,1059]],"region":{"top_left_x":249,"top_left_y":1009,"width":1597,"height":51},"line":13,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c91d99b32e8a421b9093b99d73409f2d","type":"text","conversion_output":true,"text":"Linear regression analyses were performed to evaluate the effect of Valacyclovir on changes in","text_display":"\n\nLinear regression analyses were performed to evaluate the effect of Valacyclovir on changes in","confidence":1,"confidence_rate":1},{"cnt":[[249,1057],[1803,1057],[1803,1109],[249,1109]],"region":{"top_left_x":249,"top_left_y":1057,"width":1554,"height":52},"line":14,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1b5209790d33439fb15202fb28432166","type":"text","conversion_output":true,"text":"imaging outcomes from baseline to 78 weeks. Each model included the baseline value of the","text_display":" imaging outcomes from baseline to 78 weeks. Each model included the baseline value of the","confidence":1,"confidence_rate":1},{"cnt":[[249,1106],[1871,1106],[1871,1158],[249,1158]],"region":{"top_left_x":249,"top_left_y":1106,"width":1623,"height":53},"line":15,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"44947e45ee2a436f802d6e80435a8857","type":"text","conversion_output":true,"text":"corresponding imaging measure as a covariate to control for initial differences. The models were","text_display":" corresponding imaging measure as a covariate to control for initial differences. The models were","confidence":0.99951171875,"confidence_rate":0.9999951643631956},{"cnt":[[249,1156],[1646,1156],[1646,1205],[249,1205]],"region":{"top_left_x":249,"top_left_y":1155,"width":1397,"height":51},"line":16,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c65c19e816f74fa18e65d9a8e067dd76","type":"text","conversion_output":true,"text":"further adjusted for key demographic and genetic variables, including age, sex, and","text_display":" further adjusted for key demographic and genetic variables, including age, sex, and","confidence":1,"confidence_rate":1},{"cnt":[[249,1203],[1854,1203],[1854,1253],[249,1253]],"region":{"top_left_x":249,"top_left_y":1203,"width":1606,"height":50},"line":17,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"c03b4385dc2646e088f605026fcb729c","type":"text","conversion_output":true,"text":"apolipoprotein \\(E \\varepsilon 4\\) carrier status. To assess the robustness of the findings and address potential","text_display":" apolipoprotein \\(E \\varepsilon 4\\) carrier status. To assess the robustness of the findings and address potential","confidence":0.9402373917400837,"confidence_rate":0.9994295804252348},{"cnt":[[249,1250],[1861,1250],[1861,1300],[249,1300]],"region":{"top_left_x":249,"top_left_y":1250,"width":1612,"height":50},"line":18,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"542a9099429141e19fc350bed0bb4f8e","type":"text","conversion_output":true,"text":"bias due to missing data at follow-up, sensitivity analyses were conducted using weighted linear","text_display":" bias due to missing data at follow-up, sensitivity analyses were conducted using weighted linear","confidence":1,"confidence_rate":1},{"cnt":[[249,1298],[1830,1298],[1830,1347],[249,1347]],"region":{"top_left_x":249,"top_left_y":1297,"width":1582,"height":51},"line":19,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"d28f9894115e40109532cae8f4631a3e","type":"text","conversion_output":true,"text":"regression. In these models, the weights were calculated as the inverse probability of a subject","text_display":" regression. In these models, the weights were calculated as the inverse probability of a subject","confidence":1,"confidence_rate":1},{"cnt":[[249,1345],[1880,1345],[1880,1399],[249,1399]],"region":{"top_left_x":249,"top_left_y":1344,"width":1631,"height":55},"line":20,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"022902b0a0b041a69764c1681e641c30","type":"text","conversion_output":true,"text":"being a completer, with probabilities estimated using logistic regression with ridge regularization","text_display":" being a completer, with probabilities estimated using logistic regression with ridge regularization","confidence":1,"confidence_rate":1},{"cnt":[[249,1396],[1210,1396],[1210,1446],[249,1446]],"region":{"top_left_x":249,"top_left_y":1396,"width":961,"height":50},"line":21,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"1d665833dffe41fe8d40c7b294729b6d","type":"text","conversion_output":true,"text":"to handle potential collinearity among baseline variables.","text_display":" to handle potential collinearity among baseline variables.","confidence":1,"confidence_rate":1},{"cnt":[[249,1532],[1841,1532],[1841,1583],[249,1583]],"region":{"top_left_x":249,"top_left_y":1531,"width":1593,"height":53},"line":22,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"bf85fe6d85994531a453b5143dea291d","type":"text","conversion_output":true,"text":"To assess safety, adverse events were systematically evaluated. For each type of adverse event,","text_display":"\n\nTo assess safety, adverse events were systematically evaluated. For each type of adverse event,","confidence":1,"confidence_rate":1},{"cnt":[[249,1581],[1783,1581],[1783,1631],[249,1631]],"region":{"top_left_x":249,"top_left_y":1581,"width":1535,"height":50},"line":23,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"613809f5433145ab913ace89a723c8cf","type":"text","conversion_output":true,"text":"number and proportion of participants who experienced the adverse event was reported and","text_display":" number and proportion of participants who experienced the adverse event was reported and","confidence":1,"confidence_rate":1},{"cnt":[[249,1629],[1807,1629],[1807,1678],[249,1678]],"region":{"top_left_x":249,"top_left_y":1628,"width":1558,"height":50},"line":24,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"ab2cf8a1605e4cb7863cd0ce9619915b","type":"text","conversion_output":true,"text":"compared by treatment arms using Fisher's exact test. In addition, plasma acyclovir and CSF","text_display":" compared by treatment arms using Fisher's exact test. In addition, plasma acyclovir and CSF","confidence":1,"confidence_rate":1},{"cnt":[[249,1676],[1858,1676],[1858,1725],[249,1725]],"region":{"top_left_x":249,"top_left_y":1675,"width":1610,"height":51},"line":25,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"13d59be555334993b3783bbbbf645c92","type":"text","conversion_output":true,"text":"acyclovir concentrations obtained at 12 weeks and 78 weeks were summarized using means and","text_display":" acyclovir concentrations obtained at 12 weeks and 78 weeks were summarized using means and","confidence":1,"confidence_rate":1},{"cnt":[[249,1723],[591,1723],[591,1768],[249,1768]],"region":{"top_left_x":249,"top_left_y":1723,"width":342,"height":46},"line":26,"column":0,"font_size":35,"is_printed":true,"is_handwritten":false,"id":"f2e94c0a98ca420db703915ab6122069","type":"text","conversion_output":true,"text":"standard deviations.","text_display":" standard deviations.","confidence":1,"confidence_rate":1}],"page_height":2750,"page_width":2125,"languages_detected":[]}]}

documents/10.1001_jama.2025.21990/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `b214fbb9332cea6f228beec1c6a2d190e0c7ac5233f5b81f1ae79eff36fbf1b7`).

documents/10.1001_jama.2025.23988/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `af124c7d1bc3b7bc442c4487a7896bf0bf98bfe31591139f17791ed81eed51e5`).

documents/10.1001_jama.2025.26967/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `ebca17aa89d546f84f69de84a08af539ba3e691c53ee4c75c525b0a79d5e9967`).

documents/10.1016_s0140-6736(17)33297-x/DEDUP_NOTE.md

@@ -0,0 +1,3 @@
+# Identical source PDFs
+
+`protocol.pdf` and `sap.pdf` in this folder are **byte-identical** (sha256 `9f64a224e34e8b1ccab7161b025b8944ff05f0e06e15c4ba70d14b1713daccb3`).