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9396 | passage: Isar, School of Medicine, Technische Universität München,
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Munich, Germany Search for more papers by this author Chiara Falcomatà Division of Translational Cancer Research, German Cancer Research Center (D... |
9396 | passage: Toulouse – Oncopole (IUCT-O), Hopitaux de Toulouse, Institut Claudius Regaud Toulouse,
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
France Search for more papers by this author Jean-Pierre Delord Centre de Recherches en Cancérologie de Toulouse, Ins... |
9396 | passage: title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
France Search for more papers by this author Dieter Saur orcid.org/0000-0001-5874-0210 Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), H... |
9396 | passage: ,
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Toulouse, France LABEX TouCAN, Toulouse, France Search for more papers by this author Author Information Benoit Thibault1,2, Fernanda Ramos-Delgado1,2, Elvire Pons-Tostivint1,2, Nicole Therville1,2, Cel... |
9396 | passage: bert *,1,2 1Centre de Recherches en Cancérologie de Toulouse, Inserm, CNRS,
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Université de Toulouse, Toulouse, France 2LABEX TouCAN, Toulouse, France 3Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calme... |
9396 | passage: Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK **Corresponding author.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Tel: +33 5 82 74 16 52; E-mail: [email protected] EMBO Mol Med (2021)13:e13502https://d... |
9396 | passage: investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
We searched for a gene signature that discriminate localised PDAC from confirmed m... |
9396 | passage: .
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Tumoural PI3Kα inactivation prevented the accumulation of pro-tumoural CD206-positive macrophages in the tumour-adjacent tissue. Tumour cell-intrinsic PI3Kα promotes pro-metastatic features that could b... |
9396 | passage: ; conversely, tumour cell migration is promoted by TNFα.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Higher level of cfDNA with KRAS mutation in pancreatic cancer patients is associated with increased PI3K activity markers in primary tumour. Evolut... |
9396 | passage: toskeleton remodelling. PI3Kα was inhibited in two preclinical models of pancreatic cancer.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
First, in a model of micro-metastatic disease (extra-pancreatic dissemination that goes undetected by ultrasound... |
9396 | passage: Kα activity drove the evolution of micro-metastatic disease towards the macro-metastatic stage in these models.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Mechanistically, tumour-intrinsic PI3Kα activity increased pro-tumoural characteristics in p... |
9396 | passage: forms distributed into 3 classes.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Each class I PI3K dimers, namely called PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, are composed of a catalytic subunit (p110α, p110β, p110γ and p110δ) and a regulatory subunit (p85 f... |
9396 | passage: K/Akt/mTOR pathway.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
The PI3K/Akt axis is frequently hyper-activated in cancers and has been tested as a clinical target in recent years (Pons-Tostivint et al, 2017; Goncalves et al, 2018). PI3K inhibitors... |
9396 | passage: DAC are characterised by early surgical relapse and failure of long-term disease control with chemotherapies.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Molecular characterisation of large cohorts of PDAC patients demonstrates that oncogenic KRAS ... |
9396 | passage: of the importance of this PI3K isoform in the progression of localised tumours towards a metastatic disease.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Cell-free DNA (cfDNA) and, more precisely, circulating tumour DNA (ctDNA) appears in clinical o... |
9396 | passage: .
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Because cfDNA has been studied as an exploratory biomarker of micro-metastatic disease in PDAC (Pietrasz et al, 2017; Lee et al, 2019), we proposed that detection of cfDNA, as a sign of early metastatic... |
9396 | passage: sought to determine in an unbiased manner which signalling pathway are associated with aggressive features in PDAC.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
We analysed publicly available data set to distinguish a normal pancreas from chronic pa... |
9396 | passage: constantly (equally) enriched in localised and metastatic PDAC compared to normal parenchyma.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
This trend was confirmed following Reactome pathway analysis; however, we found that PI3K cascade to FGFR2 was... |
9396 | passage: 2/9 PDACloc clustered with PDACmet.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
We further validated the PI3Kα activation signature by confirming that cancer cells isolated from peritoneal metastasis (two primary culture of patient-derived cells) p... |
9396 | passage: extended our findings to two larger independent cohorts of PDAC patients (Dataset EV2).
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
High scoring of PI3Kα activation was significantly increased in patients with the poorest prognosis, regardless of t... |
9396 | passage: . Figure 1.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
A PI3Kα-specific transcriptomic signature predicts pancreatic cancer aggressiveness List of 19 HALLMARK pathways (out of 50) significantly altered (ranked with P-value – top: low, bottom: high... |
9396 | passage: ed P-values are shown.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
ANOVA test corrected using the Benjamini and Hochberg method (BH) on SES (sample enrichment score). Significantly altered corrected P-values are highlighted in colour. Transcriptomi... |
9396 | passage: ed PDAC patients from PAAD (TCGA) or PACA-AU (BH corrected P-values).
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
The survival curves of each cluster were then plotted, and the statistical significance was calculated using the log rank test. PI3Kα ... |
9396 | passage: combined with other genetic alterations including PIK3CA mutation and PTEN deletion (Dataset EV4A).
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
We compared two different pharmacological strategies of PI3K inhibition using compounds with either isof... |
9396 | passage: title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
The most potent inhibitors, BKM120 and GDC0941, almost annihilated the pS473Akt levels at 10µM in the four cell lines and at 1 µM in only one cell line (R211, data shown in main figure) (Fig 2B–D, Appendix... |
9396 | passage: form.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
B–D. (B) Murine pancreatic tumour cells R211 were treated for 15 min with the vehicle, α, β, β/δ, γ-specific or pan-PI3K inhibitors at 1 or 10 µM in the presence of 10% FBS and the protein levels of... |
9396 | passage: filter after Crystal violet staining is shown. Scale = 200 μm. n = 3 in each group. F.
title: Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Murine pancreatic tumour cells R211 were treated with vehicle, BYL-719 1 µM, AZD4547 2 µM or both treatments and subj... |
7012 | passage: title: Firearm Purchasing and Firearm Violence in the First Months of the Coronavirus Pandemic in the United States
abstract: ABSTRACT Importance Firearm violence is a significant public health and safety problem in the United States. A surge in firearm purchases following the onset of the coronavirus pandemic... |
7012 | passage: Check System records.
title: Firearm Purchasing and Firearm Violence in the First Months of the Coronavirus Pandemic in the United States
Main Outcome and Measure Fatal and nonfatal injuries from interpersonal firearm violence, recorded in the Gun Violence Archive. Results We estimate that there were 2.1 mill... |
7012 | passage: with the coronavirus pandemic-related surge in firearm purchasing. Our findings are consistent with existing research.
title: Firearm Purchasing and Firearm Violence in the First Months of the Coronavirus Pandemic in the United States
Firearm violence prevention strategies may be particularly important during... |
5251 | passage: title: Motor Vehicle Crash Deaths — United States and 28 Other High-Income Countries, 2015 and 2019
abstract: Motor vehicle crashes are preventable, yet they continue to be a leading cause of death in the United States. An average of 36,791 crash deaths occurred each year (101 deaths each day) during 2015-2019... |
5251 | passage: was higher than the average rate among 20 other high-income countries (0.92), and the 2019 U.S.
title: Motor Vehicle Crash Deaths — United States and 28 Other High-Income Countries, 2015 and 2019
vehicle-based death rate (1.21 per 10,000 registered vehicles) was higher than the average rate among 27 other hig... |
1071 | passage: title: Psychological consequences of long COVID: comparing trajectories of depressive and anxiety symptoms before and after contracting SARS-CoV-2 between matched long- and short-COVID groups
abstract: There is a growing global awareness of the psychological consequences of long COVID, supported by emerging em... |
7108 | passage: title: Wie viele Geschlechter gibt es und kann man sie wechseln?
abstract: Zusammenfassung Die Aufteilung des Menschen in zwei Geschlechter wurde in jüngerer Vergangenheit kritisiert, da es keine genaue Grenze zwischen beiden Geschlechtern gebe und weil die Vorstellung von der Existenz zweier Geschlechter selb... |
7108 | passage: wird kritisiert und einem anderen Identitätskonzept, das therapeutische Anknüpfungspunkte bietet, gegenübergestellt.
title: Wie viele Geschlechter gibt es und kann man sie wechseln?
Ferner wird erläutert, wie sich die Kritik am klassischen Geschlechtsbegriff nachteilig für die Sexualwissenschaft sowie auch fü... |
4420 | passage: title: Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et varioliformis acuta and erythema multiforme: unravelling a possible common trigger, the COVID‐19 vaccine
abstract: Journal Article Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et vario... |
4420 | passage: other works by this author on: Oxford Academic Google Scholar E. Pezzolo, E.
title: Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et varioliformis acuta and erythema multiforme: unravelling a possible common trigger, the COVID‐19 vaccine
Pezzolo Dermatology Unit Ospedale San... |
4420 | passage: tolo Vicenza Italy Search for other works by this author on: Oxford Academic Google Scholar S. Mondino, S.
title: Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et varioliformis acuta and erythema multiforme: unravelling a possible common trigger, the COVID‐19 vaccine
Mondino... |
2251 | passage: title: Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care
abstract: Abstract Background Despite the approval of BNT162b2 mRNA vaccine for children aged 6 months to 4 years by the European Medicines Agency (EMA) and the Federal Drug Administration (FDA) in 2... |
2251 | passage: 7 days after Dose 2 to before Dose 3 as post-vaccination period (59.5+-23.6 days).
title: Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care
Results The present analysis included 4615 children aged 2.8+-1.2 years (mean+-standard deviation) who had received... |
2251 | passage: ;0.001). Differences in dosage of BNT162b2 yielded no change in VE.
title: Vaccine effectiveness of BNT162b2 mRNA Covid-19 Vaccine in Children below 5 Years in German Primary Care
Conclusion This study offers a first industry-independent insight in the potential VE of two doses of the BNT162b2 vaccine in chil... |
2956 | passage: title: An international survey of experiences and attitudes towards pacing using a heart rate monitor for people with myalgic encephalomyelitis/chronic fatigue syndrome
abstract: Myalgic encephalomyelitis (ME) is a complex, multi-system neurological condition. The defining feature of ME is post-exertional mala... |
2956 | passage: survey. The survey was open for three weeks and all answers were anonymous.488 people with ME completed the survey.
title: An international survey of experiences and attitudes towards pacing using a heart rate monitor for people with myalgic encephalomyelitis/chronic fatigue syndrome
Most participants were fe... |
9781 | passage: title: Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus
abstract: BackgroundThere is uncertainty about the mode of transmission of the severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SAR... |
9781 | passage: location (building, floor, and direction the apartment unit faced) and the probability of infection using logistic regression.
title: Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus
The spread of the airborne, virus-laden aerosols generated by the index patient was modeled wit... |
9781 | passage: The risks for the different units matched the virus concentrations predicted with the use of multizone modeling.
title: Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus
The distribution of risk in buildings B, C, and D corresponded well with the three-dimensional spread of viru... |
2659 | passage: title: Incendere : « incendier », « augmenter » ou « remplir » ? Étude sémantique
abstract: Le verbe incendere signifie usuellement « incendier » et indique qu’une personne porte le feu sur un élément du monde pour le consumer. Incendere est aussi susceptible d’emplois métaphoriques pour signifier qu’un sentim... |
4187 | passage: title: Foot stiffening during the push-off phase of human walking is linked to active muscle contraction, and not the windlass mechanism
abstract: The rigidity of the human foot is often described as a feature of our evolution for upright walking and is bolstered by a thick plantar aponeurosis that connects th... |
4187 | passage: ing and stiffening of the foot that is observed with increased foot-ground contact forces and push-off effort.
title: Foot stiffening during the push-off phase of human walking is linked to active muscle contraction, and not the windlass mechanism
Instead, electromyographic recordings suggested that active co... |
7250 | passage: title: Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination
abstract: Abstract The ChAdOx1 nCoV-19 adenoviral vector vaccine to prevent contracting Covid-19 caused by infection with SARS-CoV-2 has been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) p... |
8622 | passage: title: Developing Safe and Effective Covid Vaccines — Operation Warp Speed’s Strategy and Approach
abstract: Operation Warp Speed’s Strategy and Approach The public–private initiative Operation Warp Speed aims to deliver tens of millions of doses of an FDA-approved SARS-CoV-2 vaccine beginning at the end ... |
4353 | passage: title: Obesity and covid-19: the role of the food industry
abstract: Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture... |
4984 | passage: title: Decay of infectious SARS-CoV-2 and surrogates in aquatic environments
abstract: The introduction of SARS-CoV-2 containing human stool and sewage into water bodies may raise public health concerns. However, assessment of public health risks by faecally contaminated water is limited by a lack of knowledge... |
1641 | passage: title: Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study
abstract: Abstract Objective To examine the trends in obesity and adiposity measures, including body mass index, waist circumference, body fat percentage, and lean mass, by rac... |
1641 | passage: and lean mass were measured among adults aged 20-59 years by using dual energy x ray absorptiometry.
title: Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study
Results This study included 21 399 adults from NHANES 2011-18. Body mass i... |
1641 | passage: 6% to 62.7%) in 2017-18 (P for trend=0.02).
title: Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study
Age adjusted mean body mass index increased from 28.7 (28.2 to 29.1) in 2011-12 to 29.8 (29.2 to 30.4) in 2017-18 (P for trend=0.00... |
1641 | passage: to 33.4% in 2017-18; P for trend=0.001), but not among other racial or ethnic groups.
title: Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study
The age adjusted mean lean mass decreased in the non-Hispanic black group and increased i... |
8948 | passage: title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
abstract: Les morphiniques par voie intrathécale renforcent l’analgésie peropératoire et participent à celle postopératoire... |
8948 | passage: vants sans risque.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
Il s’agissait d’une étude prospective descriptive et analytique portant sur une période de trois mois a... |
8948 | passage: et moteur.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
L’analyse a été faite à l’aide du logiciel SPSS 10.0. Le test de Ki-2 a été utilisé pour comparer les variables... |
8948 | passage: N contre 20% pour celui M.). La durée moyenne de la chirurgie était de 90 ± 8 minutes.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
A la sortie du bloc opératoire le s... |
8948 | passage: ’a été observée qu’à la 24ème heure.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
Dans le groupe N, le recours à un complément d’analgésie par la morphine intraveineus... |
8948 | passage: (p = 0,0001).
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
Nous avions enregistrés 23,3% des cas de prurit dans le groupe N versus 33,3% dans celui M, la différence ét... |
8948 | passage: over morphine administered intrathecally has not been proven.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
We propose to compare the effectiveness of postoperative ana... |
8948 | passage: + 25 μg fentanyl + 25 μg neostigmine.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
The variables studied were demographic, hemodynamic, postoperative pain, adverse eff... |
8948 | passage: for the N group versus 20% for the M.). The average duration of the procedure was 90 ± 8 minutes.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
At the exit of the opera... |
8948 | passage: of pain was observed only at the 24th hour.
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
In group N, the use of supplemental intravenous morphine analgesia during the ... |
8948 | passage: cases in the N group versus 33.3% in the M group, the difference was not significant (P = 0.39).
title: Evaluation De L’efficacité De L’analgésie Postopératoire Procurée Par 100 μg De Morphine Versus 25 μg De Néostigmine Après Rachianesthésie Pour Fracture Du Fémur À Propos De 60 Cas
Intrathecal neostigmine a... |
3560 | passage: title: The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro
abstract: SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after... |
3560 | passage: -lauroylsarcosinate, sodium dodecyl sulfate, and copper gluconate.
title: The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro
Molecular docking simulations suggested that these ingredient... |
3622 | passage: title: Is third‐trimester abortion exceptional? Two pathways to abortion after 24 weeks of pregnancy in the United States
abstract: Abstract Context In the United States, third‐trimester abortions are substantially more expensive, difficult to obtain, and stigmatized than first‐trimester abortions. However, th... |
3622 | passage: s thematically, focusing on characterizing the experience of deciding to obtain a third‐trimester abortion.
title: Is third‐trimester abortion exceptional? Two pathways to abortion after 24 weeks of pregnancy in the United States
Results I find two pathways to needing a third‐trimester abortion: new informati... |
3622 | passage: gnancy recognition in all cases illustrate the impossibility of eliminating the need for third‐trimester abortion.
title: Is third‐trimester abortion exceptional? Two pathways to abortion after 24 weeks of pregnancy in the United States
The similarities between respondents' experiences and that of people seek... |
6021 | passage: title: Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
abstract: Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (... |
6021 | passage: as coating polymers.
title: Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
Compared with single-polymer modified GOs (GO-PEG and GO-PEI), certain dual-polymer modified GOs (GO-PEG-PEI) can act as a positive modulator to promote the maturation ... |
6021 | passage: induces stronger cellular immunity via intradermal administration, suggesting promising applications in cancer immunotherapy.
title: Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
Our work not only presents a novel, highly effective GO-based v... |
7221 | passage: title: Monitoring for SARS-CoV-2 drug resistance mutations in broad viral populations
abstract: Abstract The search for drugs against COVID-19 and other diseases caused by coronaviruses focuses on the most conserved and essential proteins, mainly the main (M pro ) and the papain-like (PL pro ) proteases and th... |
7221 | passage: -2 will emerge, and we already see that for the drugs targeting SARS-CoV-2 RdRp.
title: Monitoring for SARS-CoV-2 drug resistance mutations in broad viral populations
We hypothesize that emergence of such variants can be anticipated by identifying possible escape mutations already present in the existing popu... |
8994 | passage: title: Why women choose divorce: An evolutionary perspective
abstract: In Western dual-educated, male-female marriages, women who divorce face greater burdens because of decreased income and primary or sole responsibility for caring for children than men who divorce. Why, then, do these women initiate divorce ... |
6172 | passage: title: When evidence says no: gynaecologists’ reasons for (not) recommending ineffective ovarian cancer screening
abstract: Most patients likely assume that physicians offer medical procedures backed by solid, scientific evidence that demonstrates their superiority—or at least non-inferiority—to alternative ap... |
6172 | passage: —in average-risk women but considerable harms, including false-positive surgeries in women without ovarian cancer.
title: When evidence says no: gynaecologists’ reasons for (not) recommending ineffective ovarian cancer screening
Consequently, the US Preventive Services Task Force and medical associations worl... |
1207 | passage: title: Demographic perspectives on the mortality of COVID-19 and other epidemics
abstract: Significance What would a hypothetical 1 million US deaths in the COVID-19 epidemic mean for mortality of individuals at the population level? Life expectancy for 2020 would drop by 2.9 y. Those dying would lose an avera... |
8343 | passage: title: COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study
abstract: 10 days after the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Netherlands (on Feb 27, 2020), 55 (4%) of 1497 health-care workers ... |
8343 | passage: me sequencing of SARS-CoV-2 in clinical samples taken from health-care workers and patients.
title: COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study
We did an in-depth analysis of sources and modes of transmission of SARS-CoV-2 in health-care workers ... |
8343 | passage: patients. Most sequences were grouped in three clusters, with two clusters showing local circulation within the region.
title: COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study
The noted patterns were consistent with multiple introductions into the hos... |
2292 | passage: title: Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study
abstract: Background. The objective of this quasi-experimental study was to determine whether bolus vitamin D supplementation taken either regularly over the ... |
2292 | passage: ) score on the ordinal scale for clinical improvement (OSCI) measured during COVID-19 acute phase.
title: Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study
Potential confounders were age, gender, functional abiliti... |
2292 | passage: p = 0.33) and 68.7% survivors in Group 3 (n = 32) (p = 0.02).
title: Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study
While considering Group 3 as reference (hazard ratio (HR) = 1), the fully-adjusted HR for 14-da... |
714 | passage: title: Culture-Competent SARS-CoV-2 in Nasopharynx of Symptomatic Neonates, Children, and Adolescents
abstract: Children do not seem to drive transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We isolated culture-competent virus in vitro from 12 (52%) of 23 SARS-CoV-2-infected childr... |
6687 | passage: title: FDA urged to publish follow-up studies on covid-19 vaccine safety signals
abstract: The FDA has been criticised for taking more than a year to follow up a potential increase in serious adverse events in elderly people receiving Pfizer's covid-19 vaccine, <b>Maryanne Demasi</b> reports |
8736 | passage: title: Les limites de l’ « oncologie de précision »
abstract: The concept of precision oncology is straightforward, but the actual results of treating advanced cancer patients with the targeted drug suggested by genomic analysis have been generally disappointing, indicating that this approach is not yet ready ... |
4735 | passage: title: A Follow-Up Study of Boys With Gender Identity Disorder
abstract: This study reports follow-up data on the largest sample to date of boys clinic-referred for gender dysphoria ( n = 139) with regard to gender identity and sexual orientation. In childhood, the boys were assessed at a mean age of 7.49 year... |
4735 | passage: for both fantasy and behavior and then dichotomized as either biphilic/androphilic or gynephilic.
title: A Follow-Up Study of Boys With Gender Identity Disorder
Of the 139 participants, 17 (12.2%) were classified as persisters and the remaining 122 (87.8%) were classified as desisters. Data on sexual orientat... |
4735 | passage: gynephilic desisters, with the biphilic/androphilic desisters as the reference group.
title: A Follow-Up Study of Boys With Gender Identity Disorder
Compared to the reference group, the biphilic/androphilic persisters tended to be older at the time of the assessment in childhood, were from a lower social clas... |
2745 | passage: title: On the origin and continuing evolution of SARS-CoV-2
abstract: The SARS-CoV-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other r... |
2745 | passage: and viruses from pangolin SARSr-CoVs are likely caused by natural selection besides recombination.
title: On the origin and continuing evolution of SARS-CoV-2
Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages (designated L and S), that are well defined b... |
3337 | passage: title: Language matters: representations of ‘heart failure’ in English discourse—a large-scale linguistic study
abstract: Heart failure (HF) has a lower public profile compared with other serious health conditions, notably cancer. This discourse analysis study investigates the extent to which HF is discussed i... |
7456 | passage: title: The latest HyPe(r) in plant H2O2 biosensing
abstract: HyPer7 senses minute amounts of H2O2 independent of pH and the glutathione redox potential and enables detection of physiological H2O2 fluxes within the cytosol and between subcellular compartments. |
8615 | passage: title: Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans
abstract: Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the post-smallpox eradication era. The clinical presentation of monkeypox is similar to the one of smal... |
8615 | passage: , the objective of this review is to trace all reported human monkeypox outbreaks and relevant epidemiological information.
title: Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans
The frequency and geographical spread of human monkeypox cases have increased in recent years, and t... |
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