entry stringlengths 6 10 | cc_function stringlengths 75 10.3k | question stringlengths 58 156 |
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A0A0C3VJP4 | FUNCTION: Carboxypeptidase that, together with KPI106, controls mycorrhiza establishment and arbuscule development during root colonization by arbuscular mycorrhizal (AM) fungi (e.g. Rhizophagus irregularis). {ECO:0000269|PubMed:23662629}. | I would like a protein that is a carboxypeptidase controlling mycorrhizal symbiosis and arbuscule development in plant roots. |
A0A0C5B5G6 | FUNCTION: Regulates insulin sensitivity and metabolic homeostasis (PubMed:25738459, PubMed:33468709). Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the meta... | I need a protein that inhibits the folate cycle to activate AMPK and protect against diet-induced insulin resistance and obesity. |
A0A0C5CJR8 | FUNCTION: Peptidase able to cleave azocasein and the milk substrates beta-casein and Na-caseinate. Can withstand UHT processing of milk, and is able to spoil UHT milk over the storage period. {ECO:0000269|Ref.1}. | Find me a protein that is a heat-stable peptidase that cleaves milk caseins and survives ultra-high-temperature processing. |
A0A0C5PHQ7 | FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that... | I am looking for a protein that elongates polyunsaturated fatty acids by adding 2-carbon units in the endoplasmic reticulum. |
A0A0C5Q4Y6 | FUNCTION: Monooxygenase involved in the biosynthesis of labdane-related diterpenes natural products (PubMed:26020634, PubMed:27703160). Catalyzes the oxidation of abietatriene to produce ferruginol (PubMed:26020634, PubMed:27703160). Catalyzes the oxidation of ferruginol at C-12 to produce 11-hydroxyferruginol (PubMed:... | Give me a protein that is a monooxygenase converting abietatriene to ferruginol during carnosate diterpene biosynthesis. |
A0A0C5QRZ2 | FUNCTION: Monooxygenase involved in the biosynthesis of labdane-related diterpenes natural products (PubMed:26020634, PubMed:27703160). Catalyzes the oxidation of abietatriene to produce ferruginol (PubMed:26020634, PubMed:27703160). Catalyzes the oxidation of ferruginol at C-12 to produce 11-hydroxyferruginol (PubMed:... | I want a protein that oxidizes abietatriene and ferruginol to produce antioxidant labdane diterpene intermediates. |
A0A0C5XL88 | FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Expression in E.coli inhibits cell growth; bacteriostasis is neutralized by expression of cognate antitoxin ParS. ADP-ribosylates E.coli ribose-phosphate pyrophosphokinase (RPPK, prs) using NAD(+) in vitro; ADP-ribosylates RPPK on 'Lys-182' and 'Ser-20... | Design a protein that is a bacterial toxin ADP-ribosylating ribose-phosphate pyrophosphokinase to inhibit cell growth. |
A0A0C6DRW4 | FUNCTION: Catalyzes the first step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide) in a stepwise manner (PubMed:11229908, Ref.2). Also acts on thioxa... | Suggest a protein that oxidizes dibenzothiophene to DBT-sulfone without breaking carbon-carbon bonds for biodesulfurization. |
A0A0D1CKI0 | FUNCTION: Aerial growth, conidiation, and dispersal of filamentous fungi in the environment rely upon a capability of their secreting small amphipathic proteins called hydrophobins (HPBs) with low sequence identity. Class I can self-assemble into an outermost layer of rodlet bundles on aerial cell surfaces, conferring ... | Generate a protein that self-assembles into amphipathic rodlets on fungal aerial surfaces to confer hydrophobicity. |
A0A0D1DWQ2 | FUNCTION: Secreted chorismate mutase that is one component of a cocktail of effectors shaping the host metabolome and acting as virulence factors. The enzyme is taken up by plant cells, can spread to neighboring cells where it affects the biosynthesis of the plant immune signal salicylic acid by channelling chorismate ... | Provide a protein that enters plant cells and channels chorismate away from salicylic acid biosynthesis to suppress immunity. |
A0A0D1DWZ5 | FUNCTION: Key RNA-binding protein involved in the formation of polar-growing hyphae which is essential for infection by the plant pathogen (PubMed:15643068, PubMed:17105762, PubMed:19494833). During filamentation, assembles into particles that shuttle bidirectionally along microtubules to both poles (PubMed:17105762, P... | I would like a protein that packages mRNAs into transport particles and shuttles them along microtubules to polarize fungal hyphae. |
A0A0D1E015 | FUNCTION: FYVE zinc finger domain protein that functions in endosomal targeting and transport of mRNAs, as well as associated ribosomes (PubMed:25985087, PubMed:28422978). The endosomal mRNA transport regulates polarity of the infectious hyphae by transporting a broad spectrum of cargo mRNAs from the nucleus to cell po... | I need a protein that anchors to endosomal membranes via a FYVE domain to recruit mRNA transport machinery in fungal hyphae. |
A0A0D2UG83 | FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regula... | Find me a protein that is a histone H2A variant that represses transcription and limits PARP1-driven NAD+ consumption. |
A0A0D2Y5A7 | FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (PubMed:34927582). High pyruvate dehydrogenase complex activity is required for sufficient energy production during germination of conidia (PubMed:34927582). {ECO:0000269|PubMed:34927582}. | I am looking for a protein that catalyzes the conversion of pyruvate to acetyl-CoA as part of the pyruvate dehydrogenase complex. |
A0A0D4WTV1 | FUNCTION: Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (PubMed:25752604). This toxin acts on sphingomyelin (SM) and on ceramide phosphoethanolamine (C... | Give me a protein that cleaves sphingolipid headgroups via transphosphatidylation to cause dermonecrosis and hemolysis. |
A0A0D4WV12 | FUNCTION: Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (PubMed:25752604). This toxin acts on lysophosphatidylethanolamine (LPE) and ceramide phosphoet... | I want a protein that is a dermonecrotic toxin cleaving lysophospholipid headgroups via transphosphatidylation. |
A0A0D9S1R0 | FUNCTION: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoprot... | Design a protein that mediates lipoprotein-mediated lipid transport between tissues and receptor-driven cholesterol clearance. |
A0A0E3D8M9 | FUNCTION: Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes janthitremanes such as shearinine K or shearinine A (PubMed:26213965). Within the pathway, the geranylgeranyl diphosphate (GGPP) synthase janG catalyzes the first step in janthitremane biosy... | Suggest a protein that converts farnesyl pyrophosphate and isopentenyl pyrophosphate to geranylgeranyl pyrophosphate. |
A0A0E3D8P4 | FUNCTION: Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965). Within the pathway, the geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in janthitremane biosynthesis via conversion of farnesyl pyropho... | Generate a protein that synthesizes geranylgeranyl pyrophosphate from farnesyl pyrophosphate and IPP in indole diterpene biosynthesis. |
A0A0E3JXD9 | FUNCTION: Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. {ECO:0000269|PubMed:25900453}. | Provide a protein that oxidatively deaminates D-amino acids with broad substrate specificity. |
A0A0E3KBH3 | FUNCTION: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives. {ECO:0000269|PubMed:16466637}. | I would like a protein that performs CoA-dependent oxidative decarboxylation of 2-oxoacids including pyruvate and 2-oxoglutarate. |
A0A0E3T3B5 | FUNCTION: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:26296314). Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (P... | I need a protein that oxidizes aminoaldehyde byproducts of polyamine degradation to non-toxic amino acids. |
A0A0E3T552 | FUNCTION: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:26296314). Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (P... | Find me a protein that detoxifies aminoaldehydes from polyamine degradation by converting them to amino acids. |
A0A0F5HNH9 | FUNCTION: Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like iron-binding protein probably involved in iron mineralization in the encapsulin nanocompartment. Has ferroxidase activity even when encapsulated, the rate is probably controlled by the rate of Fe flux across the nanocompartment pores (PubMe... | I am looking for a protein that mineralizes iron inside an encapsulin nanocompartment via ferroxidase activity. |
A0A0F6B5X3 | FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:29777131, PubMed:34556858). Counteracts the toxic effect of cognate toxin TacT3, but not TacT1 or TacT2 (PubMed:29777131, PubMed:34556858). Plays a role in persister cell formation (PubMed:24408438). {ECO:0000269|PubMed:24408438, ECO:0000269... | Give me a protein that is a bacterial antitoxin neutralizing tRNA acetyltransferase toxicity and regulating persister cell formation. |
A0A0F6B5X4 | FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system (PubMed:29777131, PubMed:34556858). Acetylates tRNA and inhibits translation (PubMed:29777131). Acetylates only Gly-tRNA on all 3 Gly-tRNA(Gly) isoacceptors in situ (PubMed:35609997). In vitro acetylates mainly Ile/Leu and Gly (PubMed:29777131). Overexp... | I want a protein that acetylates Gly-tRNA to block translation and promote bacterial persister cell formation. |
A0A0F6B8D8 | FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system (PubMed:29777131, PubMed:27264868, PubMed:34556858). Acetylates tRNA and inhibits translation, does not acetylate uncharged tRNA (PubMed:27264868, PubMed:29777131). Upon expression in situ acetylates only Gly-tRNA(Gly) (PubMed:35609997). In vitro acetyl... | Design a protein that is a bacterial tRNA acetyltransferase toxin that extends lag phase and promotes persister cell formation. |
A0A0F6B8D9 | FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:27264868, PubMed:34556858). Counteracts the toxic effect of cognate toxin TacT1 (T8), but not TacT2 or TacT3 (PubMed:27264868, PubMed:34556858). Plays a role in persister cell formation (PubMed:24408438). {ECO:0000269|PubMed:24408438, ECO:00... | Suggest a protein that is a bacterial antitoxin neutralizing a tRNA acetyltransferase and autoregulating its own operon. |
A0A0F7G352 | FUNCTION: Involved in the biosynthesis of vanillin (4-hydroxy-3-methoxy-benzaldehyde) and derivative natural products, key components of vanilla pods flavor (PubMed:24941968, PubMed:29186560). Catalyzes the double carbon bond cleavage of ferulic acid to vanillin and of their respective glucosides via a coupled non-oxid... | Generate a protein that converts ferulic acid to vanillin via a coupled non-oxidative hydratase/lyase reaction. |
A0A0F7KYQ8 | FUNCTION: Class B beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems (PubMed:32229489). Acts via hydrolysis of the beta-lactam ring (PubMed:15561840, PubMed:28971872). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed... | Provide a protein that is a metallo-beta-lactamase hydrolyzing the beta-lactam ring of penicillins, cephalosporins, and carbapenems. |
A0A0G2JDV3 | FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551... | I would like a protein that is an IFN-inducible GTPase conferring innate immune protection against bacterial and protozoan pathogens. |
A0A0G2JTR4 | FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulati... | I need a protein that has both GTPase-activating and guanine nucleotide exchange activities to bidirectionally regulate Rho GTPases. |
A0A0G2JTY4 | FUNCTION: Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in oste... | Find me a protein that is a calcium-regulated transcription factor promoting RANKL expression and T-cell cytokine induction. |
A0A0G2JTZ2 | FUNCTION: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for cho... | I am looking for a protein that cooperates with SOX9 on cartilage enhancers to activate chondrocyte differentiation genes. |
A0A0G2JUG7 | FUNCTION: Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (By... | Give me a protein that is a GEF for ARF6 mediating integrin internalization and synaptic AMPA receptor endocytosis. |
A0A0G2JV04 | FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR ... | I want a protein that recruits clathrin to the trans-Golgi network to sort proteins between the Golgi and endosomes. |
A0A0G2JXN2 | FUNCTION: Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. ... | Design a protein that organizes parallel microtubule bundles in the proximal axon to support cargo trafficking and neuronal polarity. |
A0A0G2JXT6 | FUNCTION: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also ... | Suggest a protein that dephosphorylates phosphatidylinositol 3-phosphate to negatively regulate ER-to-Golgi vesicular transport. |
A0A0G2JZ79 | FUNCTION: NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through dea... | Generate a protein that is an NAD-dependent deacetylase linking cellular energy status to chromatin regulation and metabolic homeostasis. |
A0A0G2K047 | FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (PubMed:28003429). {ECO:0000269|PubMed:28003429}. | Provide a protein that synthesizes acyl-CoA from short-chain fatty acids, with highest activity toward propionate. |
A0A0G2K1Q8 | FUNCTION: Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine contai... | I would like a protein that is an ABC transporter pumping phosphatidylcholine into lamellar bodies for pulmonary surfactant production. |
A0A0G2K2P5 | FUNCTION: TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space a... | I need a protein that scaffolds tight junction transmembrane proteins to the actin cytoskeleton for epithelial barrier formation. |
A0A0G2K309 | FUNCTION: Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic ... | Find me a protein that is a mitochondrial ornithine-citrulline antiporter linking urea cycle reactions across the inner membrane. |
A0A0G2K344 | FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 p... | I am looking for a protein that phosphorylates PtdIns(4,5)P2 to produce PIP3 and activate AKT during growth factor signaling. |
A0A0G2KQY6 | FUNCTION: Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. {ECO:0000269|PubMed:27231142}.; FUNCTION: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that... | Give me a protein that cotransports divalent metal cations with bicarbonate across membranes to import zinc, manganese, and iron. |
A0A0G2KTI4 | FUNCTION: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042). Important for maintenance of endolymph volume in the otic vesicle,... | I want a protein that electroneutrally cotransports chloride with cations to regulate ionic balance and cell volume. |
A0A0G2L7I0 | FUNCTION: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication an... | Design a protein that is a metalloendopeptidase cleaving covalent DNA-protein cross-links during replication to maintain genome integrity. |
A0A0G2Q9D6 | FUNCTION: A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Relaxes negatively supercoiled DNA in an ATP-independent ma... | Suggest a protein that is a type II topoisomerase introducing negative supercoils into circular double-stranded DNA using ATP. |
A0A0G2Q9F8 | FUNCTION: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and... | Generate a protein that negatively supercoils double-stranded DNA to regulate chromosome topology for replication and transcription. |
A0A0G2QC33 | FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. The protease activity is required for proteolytic activation of ATG8 fami... | Provide a protein that is a cysteine protease processing ATG8 family proteins to initiate autophagosome membrane formation. |
A0A0G2UGT2 | FUNCTION: D-galactose-binding lectin (PubMed:26802895, Ref.2). Binds both alpha and beta anomer of galactose (Gal). Binds strongly to branched beta-Gal-terminated glycans and weakly to unbranched glycans with alpha-Gal on the end of chains (PubMed:31905927). Has strong affinity for both Gal and GalNAc. Binds glycoprote... | I would like a protein that is a galactose-binding lectin with antifungal, hemagglutinating, and immunomodulatory activity. |
A0A0G4P2K0 | FUNCTION: Self-sufficient cytochrome P450 monooxygenase that catalyzes the regioselective in-chain hydroxylation of alkanes, fatty alcohols, and fatty acids at the omega-7 position (PubMed:36607403). Performs hydroxylation of C10-C16 n-alkanes and C12 and C14 fatty alcohols; and thereby enables the one step biocatalyti... | I need a protein that is a self-sufficient cytochrome P450 hydroxylating fatty acids at the omega-7 position for rare alcohol synthesis. |
A0A0H2UNG0 | FUNCTION: Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells (PubMed:21565699). Hydrolyzes the alpha-1,6-branchpoints of glycogen (PubMed:20497336, PubMed:21565699). Hydrolyzes pullulan. Does not hydrolyze dextran (PubMed:20497336). Binds to mouse lung alveolar type II... | Find me a protein that hydrolyzes alpha-1,6 branch points of host glycogen as a virulence factor during lung infection. |
A0A0H2URG7 | FUNCTION: Required for the polymorphic O-glycosylation of serine-rich repeat protein PsrP. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in PsrP (PubMed:24936067, PubMed:28246170). Part of the accessory SecA2/SecY2 system specifically required to export... | I am looking for a protein that transfers N-acetylglucosamine to serine residues as the first step in O-glycosylation of surface adhesins. |
A0A0H2URJ6 | FUNCTION: Involved in the polymorphic O-glycosylation of the serine-rich repeat protein PsrP. Catalyzes the third step in glycosylation of PsrP in this bacteria. Transfers galactose from UDP-galactose to the terminal glucose moiety of already-glycosylated PsrP (using the short substrate PsrP-GlcNAc-Glc). Has a very mar... | Give me a protein that transfers galactose onto a pre-glycosylated serine-rich repeat bacterial surface adhesin. |
A0A0H2URK1 | FUNCTION: Protein that allows bacteria to adhere to mammalian host cells. Required for full virulence in mouse infection models when infected intranasally (PubMed:16861665). Required for adhesion to host cells in vitro and for persistence in the lower respiratory tract (PubMed:18507531). Binds host keratin 10 (KRT10) o... | I want a protein that binds host keratin 10 to mediate bacterial adhesion to lung cells and promote biofilm formation. |
A0A0H2URU9 | FUNCTION: Major component of the type IV-like pilus (T4P) that plays a role in transformation (PubMed:28659339). Transformation pili are dynamically extended and retracted, perhaps thereby promoting DNA uptake and transformation (By similarity). Required for transformation (PubMed:24550320). Required for DNA binding (B... | Design a protein that is the major pilin of a type IV pilus required for DNA binding and natural transformation. |
A0A0H2US87 | FUNCTION: ADP-riboxanase effector that inhibits host cell pyroptosis (PubMed:23684308, PubMed:34409271, PubMed:34671164, PubMed:36624349). Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing (PubMed:34671164, PubMed:35338844, PubMed:35568036, PubMed:36624349, PubMed:37... | Suggest a protein that ADP-riboxanates host caspase-4 to block LPS-induced pyroptosis during bacterial infection. |
A0A0H2USC0 | FUNCTION: E3 ubiquitin-protein ligase effector that inhibits host cell innate immunity during bacterial infection by catalyzing 'Lys-48'-linked polyubiquitination and subsequent degradation of host RNF31/HOIP (PubMed:27572974, PubMed:36610722). Host RNF31/HOIP is the catalytic component of the LUBAC complex, which conj... | Generate a protein that is a bacterial E3 ubiquitin ligase degrading host RNF31 to prevent ubiquitin coat formation around bacteria. |
A0A0H2USG1 | FUNCTION: E3 ubiquitin-protein ligase effector that inhibits host cell innate immunity during bacterial infection by catalyzing 'Lys-48'-linked polyubiquitination and subsequent degradation of host RNF31/HOIP and RBCK1/HOIL-1 (PubMed:18997778, PubMed:27572974, PubMed:35294289, PubMed:36610722). Host RNF31/HOIP is the c... | Provide a protein that is a bacterial E3 ubiquitin ligase degrading LUBAC components to evade xenophagy and NF-kB-driven immunity. |
A0A0H2V871 | FUNCTION: Catalyzes the hydrolysis of both the apo and Fe3(+)-bound forms of enterobactin (Ent), monoglucosyl-C-Ent (MGE), diglucosyl-C-Ent (DGE) and triglucosyl-C-Ent (TGE). It prefers apo siderophores as substrates and hydrolyzes the Fe3(+)-bound siderophores very inefficiently. Tends to hydrolyze the trilactone just... | I would like a protein that hydrolyzes enterobactin and glucosylated enterobactin siderophores, preferring the apo forms. |
A0A0H2V8B5 | FUNCTION: Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage (PubMed:18327267, PubMed:20886104). Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into A... | I need a protein that is a bacterial NADase virulence factor that suppresses host TLR-mediated cytokine production. |
A0A0H2VG78 | FUNCTION: Transporter highly specific for glucose uptake. {ECO:0000269|PubMed:24127585}. | Find me a protein that is a highly specific glucose transporter. |
A0A0H2WWV6 | FUNCTION: Attaches N-acetyl-alpha-D-glucosamine residues to poly(RboP)-wall teichoic acids (WTAs). {ECO:0000269|PubMed:20185825, ECO:0000269|PubMed:25624472, ECO:0000269|PubMed:25697358}. | I am looking for a protein that attaches N-acetylglucosamine residues to poly(RboP) wall teichoic acids. |
A0A0H2WZ38 | FUNCTION: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:22303291). The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT (PubMed:... | Give me a protein that hydrolyzes glutamine to generate ammonia for isoglutamine formation in cell wall lipid II synthesis. |
A0A0H2X5R2 | FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD (PubMed:38429435). Plays an important role in the biosynthesis of NAD via the nicotinamide (NAM) salvage pathway (PubMed:38429435). Is also capable ... | I want a protein that condenses nicotinamide with phosphoribosyl pyrophosphate to synthesize NMN in the NAD salvage pathway. |
A0A0H2Z7X0 | FUNCTION: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (PubMed:20946878). Important for the regulation of biofilm maintenance when exposed to peroxide (PubMed:34694901). {ECO:0000269|PubMed:20946878, ECO:0000269|PubMed:34694901}.; FUNCTION: Part of the YfiB-TpbB-YfiR (or y... | Design a protein that synthesizes cyclic-di-GMP from two GTP molecules to regulate biofilm formation under stress. |
A0A0H2ZFK2 | FUNCTION: Phosphatase that regulates diverse phenotypes in P.aeruginosa via regulation of the concentration of cellular c-di-GMP (PubMed:19543378). Acts by dephosphorylating the membrane-anchored diguanylate cyclase TpbB at tyrosine and serine/threonine sites, leading to inactivation of TpbB and reduced c-di-GMP produc... | Suggest a protein that dephosphorylates a diguanylate cyclase to lower c-di-GMP levels and reduce biofilm formation. |
A0A0H2ZL64 | FUNCTION: Virulence factor (PubMed:17041037). Involved in the degradation of glycogen of the mammalian host cells. Hydrolyzes the alpha-1,6-branchpoints of glycogen. Hydrolyzes pullulan. Does not hydrolyze dextran. Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific ... | Generate a protein that hydrolyzes alpha-1,6 branch points of host glycogen as a virulence factor enabling lung colonization. |
A0A0H2ZLQ1 | FUNCTION: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation (By similarity). Involved in peripheral peptidoglycan (PG) synthesis (PubMed:26933838). {ECO:0000250|UniProtKB:P28306, ECO:0000255|HAMAP-Rule:MF_02065, ECO:0000269|PubMed:26933838}. | Provide a protein that endolytically cleaves nascent peptidoglycan strands to terminate their elongation during cell wall synthesis. |
A0A0H2ZMF9 | FUNCTION: Cell wall formation. Synthesis of cross-linked peptidoglycan (PG) from the lipid intermediates (By similarity). Binds dansylated lipid II and catalyzes the polymerization of glycan chains. Hydrolyzes S2d (N-benzoyl-D-alanylmercaptoacetic acid) molecule, a synthetic thiolester analog of cell wall stem peptide.... | I would like a protein that polymerizes glycan chains from lipid II intermediates to build bacterial peptidoglycan. |
A0A0H2ZNH9 | FUNCTION: Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism (By similarity). Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR (By similarity). In turn, WalR binds to the upstream ... | I need a protein that is a two-component histidine kinase regulating cell wall metabolism genes and contributing to bacterial virulence. |
A0A0H2ZQ76 | FUNCTION: Peptidoglycan-hydrolase activity (PubMed:24804636). Required in maintaining normal growth and cellular morphology (PubMed:19270090, PubMed:22006325). Involved in splitting of the septum during cell division (By similarity). {ECO:0000250|UniProtKB:Q8DMY4, ECO:0000269|PubMed:19270090, ECO:0000269|PubMed:2200632... | Find me a protein that has peptidoglycan hydrolase activity to split the division septum during bacterial cell division. |
A0A0H2ZQB9 | FUNCTION: Part of an ABC transporter complex EgtU required for the uptake of ergothioneine (EGT), a natural low-molecular weight (LMW) thiol antioxidant (PubMed:36481738). Responsible for the translocation of the substrate across the membrane (PubMed:36481738). Also contains a C-terminal periplasmic solute-binding doma... | I am looking for a protein that is an ABC transporter mediating highly specific uptake of the antioxidant ergothioneine. |
A0A0H2ZQL5 | FUNCTION: Plays a role in cell cycle regulation and chromosome integrity. Activates DnaA-dependent chromosomal DNA replication initiation ensuring that the chromosome is replicated at the right time during the cell cycle (PubMed:34373624). May regulate replication initiation through phosphorylation of a possible second... | Give me a protein that activates DnaA-dependent chromosomal replication initiation to ensure timely cell cycle progression. |
A0A0H3AIG7 | FUNCTION: Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (By similarity). Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the deli... | I want a protein that covalently cross-links actin monomers as a type VI secretion toxin to disrupt the host cytoskeleton. |
A0A0H3AMJ9 | FUNCTION: Acts as a response regulator to control chemotaxis (PubMed:16321945, PubMed:24066084). Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors (PubMed:16321945, PubMed:24066084). Switches the flagellar rotation by binding to the flagellar motor switch protein FliM (PubM... | Design a protein that is a chemotaxis response regulator switching flagellar rotation from counterclockwise to clockwise. |
A0A0H3C8X0 | FUNCTION: Involved in de novo bacterial ceramide synthesis (PubMed:33063925, PubMed:34969973). Catalyzes the condensation of 3-oxosphinganine with an acyl-CoA to generate oxidized ceramides (PubMed:34969973). Can use acyl-CoA substrates ranging from C8 to C24, with highest in vitro activity with C14 and very little act... | Suggest a protein that condenses 3-oxosphinganine with acyl-CoA to produce ceramides in bacterial sphingolipid biosynthesis. |
A0A0H3GDH9 | FUNCTION: Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PG). Also deacetylates N-acetylated PG. Does not deacetylate N-acetylmuramic acid (By similarity). Confers host lysozyme resistance. Critical for virulence and escape from innate immune response of the host (PubMed:21768286... | Generate a protein that deacetylates peptidoglycan GlcNAc residues to confer lysozyme resistance and promote virulence. |
A0A0H3GGY3 | FUNCTION: A phosphodiesterase (PDE) that hydrolyzes cyclic di-3',5'-adenylate (c-di-AMP); there are at least 2 PDEs for c-di-AMP in this bacteria (this and pdeA), this may be the major PDE for growth in liquid culture (PubMed:25583510). During host infection c-di-AMP is secreted into the host cytoplasm which leads to i... | Provide a protein that is a phosphodiesterase degrading cyclic-di-AMP second messengers during bacterial infection. |
A0A0H3JN63 | FUNCTION: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:22291598, PubMed:30154570). The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site... | I would like a protein that is a glutaminase subunit providing ammonia for isoglutamine formation in bacterial cell wall synthesis. |
A0A0H3JNB0 | FUNCTION: Attaches beta-O-GlcNAc (beta-O-N-acetyl-D-glucosamine) residues to the C3 position of poly(RboP)-wall teichoic acids (WTAs). Attenuates immunogenicity of WTA and protects S.aureus against adaptative host defenses by allowing bacteria to evade recognition by preexisting anti-S.aureus antibodies. Also protects ... | I need a protein that modifies wall teichoic acids with beta-O-GlcNAc to shield bacteria from antibody recognition. |
A0A0H3JPC6 | FUNCTION: Attaches beta-O-GlcNAc (beta-O-N-acetyl-D-glucosamine) residues to the C4 position of poly(RboP)-wall teichoic acids (WTAs). Mediates beta-lactam resistance in methicillin resistant Staphylococcus aureus (MRSA) strains. {ECO:0000269|PubMed:27973583}. | Find me a protein that GlcNAcylates wall teichoic acids at the C4 position to mediate beta-lactam resistance in MRSA. |
A0A0H3JRU9 | FUNCTION: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. {ECO:0000269|PubMed:19523900, ECO:0000269|PubMed:23286247}. | I am looking for a protein that carboxylates pyruvate via ATP-dependent biotin-mediated carboxylation. |
A0A0H3JUU7 | FUNCTION: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:22291598, PubMed:30154570). The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue (PubMed:222... | Give me a protein that ATP-dependently amidinates D-glutamate in lipid II to form isoglutamine during cell wall biosynthesis. |
A0A0H3K686 | FUNCTION: Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins (By similarity). In turn, Staphylococcus au... | I want a protein that captures immunoglobulin Fc and Fab regions to block phagocytosis and suppress antibody-mediated immunity. |
A0A0H3KB22 | FUNCTION: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. {ECO:0000255|HAMAP-Rule:MF_00917, ECO:0000269|PubMed:24362703}. | Design a protein that converts CPH4 to 7-carboxy-7-deazaguanine via a radical-mediated reaction in 7-deazapurine biosynthesis. |
A0A0H3KZS3 | FUNCTION: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HGA) to 2-oxoglutarate. Appears to be the only D2HGDH in P.ananatis, providing the way to recycle D-2-HGA produced during L-serine synthesis by SerA, by converting it back to 2-oxoglutarate. Is involved in the utilization of D-2-HGA, that can support the gr... | Suggest a protein that oxidizes D-2-hydroxyglutarate to 2-oxoglutarate with strict substrate specificity. |
A0A0H3LKL4 | FUNCTION: Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway (PubMed:27218267, PubMed:30810301). Is also active on the non-nat... | Generate a protein that is a flavin-dependent monooxygenase decarboxylatively hydroxylating 6-hydroxynicotinic acid in nicotinate catabolism. |
A0A0H3LM39 | FUNCTION: Selective electrodiffusional channel that mediates the uptake of Zn(2+). Exploits in vivo zinc concentration gradients (maintained by cellular zinc homeostasis) to passively move zinc ions into the cytoplasm. ZIPB-mediated zinc flux is dependent upon pH, but independent of the proton motive force. Is also abl... | Provide a protein that is a selective zinc ion channel mediating passive electrodiffusional zinc uptake into the cytoplasm. |
A0A0H3M5A8 | FUNCTION: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. {ECO:0000269|PubMed:24093492}.; FUNCTION: Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM). PMM is an alkai-stable sugar dono... | I would like a protein with dual activity as a lipoprotein N-acyltransferase and a mannosyltransferase for cell wall glycolipid biosynthesis. |
A0A0H3MDW1 | FUNCTION: May be a global positive regulator of transcription (PubMed:21057008). Binds a cis-acting element of its own promoter DNA sequence and is hence probably also involved in its own transcription activation (PubMed:21057008, PubMed:21775428, PubMed:24646934). The recognition sequence is 5'-WHGAWNH-N(3-5)-WHGAWNH-... | I need a protein that is a global transcription activator that autoregulates its own expression by binding a palindromic promoter motif. |
A0A0H3NK84 | FUNCTION: Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling, apoptosis and necroptosis (PubMed:30327479, PubMed:32766249). Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the... | Find me a protein that transfers GlcNAc to arginine residues in host death domain proteins to block TNF receptor-mediated signaling. |
A0A0H3PEK7 | FUNCTION: Catalyzes the 2'-O-methylation at nucleotide C1920 in 23S rRNA (PubMed:24796671, PubMed:29404277). Enhances motility (PubMed:24796671, PubMed:29404277, PubMed:32134554). Enhances biofilm formation (PubMed:29404277, PubMed:32134554). Involved in the assembly of 70S ribosomes (PubMed:24796671). Involved in viru... | I am looking for a protein that 2'-O-methylates 23S rRNA to enhance bacterial virulence, biofilm formation, and motility. |
A0A0H3PJK4 | FUNCTION: The heterotetrameric DLP1(2)-DLP2(2) complex tethers liposomes and may mediate their fusion. Initial binding is probably mediated by DLP1, while DLP2 couples DLP1 subunits and increases the effective reach of the complex up to 45 nm. The role of the nucleotide is unknown. This subunit alone very weakly binds ... | Give me a protein that forms a heterotetrameric membrane-tethering complex with dynamin-type GTPase activity. |
A0A0H5BMX5 | FUNCTION: Lactone-forming carboxylesterase, specifically catalyzing intramolecular transesterification, but not hydrolysis. Involved in the biosynthesis of tulipalins, defensive chemicals that show antimicrobial activities against a broad range of strains of bacteria and fungi. Substrates are 6-tuliposide B > 6-tulipos... | I want a protein that converts tuliposides to antimicrobial tulipalins via intramolecular transesterification. |
A0A0J5ZXG5 | FUNCTION: Pycsar (pyrimidine cyclase system for antiphage resistance) provides immunity against bacteriophage. The pyrimidine cyclase (PycC) synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate the adjacent effector, leading to bacterial cell de... | Design a protein that synthesizes cyclic UMP from UTP as a second messenger to activate antiphage bacterial immunity. |
A0A0J9SZQ5 | FUNCTION: Sodium-independent facilitative hexose transporter (By similarity). Can transport D-glucose and D-fructose (PubMed:12792024, PubMed:15107012). Can transport D-mannose, D-galactose, D-xylose and D-glucosamine (By similarity). {ECO:0000250|UniProtKB:Q700M0, ECO:0000250|UniProtKB:Q7KWJ5, ECO:0000269|PubMed:12792... | Suggest a protein that is a sodium-independent hexose transporter facilitating uptake of glucose, fructose, and mannose. |
A0A0J9UMG2 | FUNCTION: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable). ChsV and chsVb do perform additive, but not redundant, functions in septum formation (PubMed:17993572). Involved in cell wall i... | Generate a protein that polymerizes chitin from UDP-GlcNAc for fungal cell wall integrity and pathogenicity. |
A0A0J9UVG7 | FUNCTION: NAD-dependent protein-lysine deacylase that decrotonylates the PDC (pyruvate dehydrogenase complex) subunit LAT1 at 'Lys-148' to inhibit PDC activity and consequently ATP production (PubMed:34927582). Also decrotonylates histone H3 crotonylated at 'Lys-18' (H3K18cr), to repress the expression of genes involve... | Provide a protein that is an NAD-dependent decrotonylase removing crotonyl modifications to inhibit energy metabolism. |
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