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note_49965_span_Male_1800000_1850000_mid_mesh | mice. Male Swiss mice | NEW FINDINGS: What is the central question of this study? What are the temporal responses of mitochondrial respiration and mitochondrial responsivity to insulin in soleus muscle fibres from mice during the development of obesity and insulin resistance? What is the main finding and its importance? Short- and long-term f... | false | note_49965 | note_49965_ mice. Male Swiss mice | 824,210 |
note_49966_span_Disease Models, Animal_1800000_1850000_mid_mesh | reoccurrence.PATIENTS: | OBJECTIVE: To describe a serious iatrogenic injury and propose means of reducing the risk of its<think> A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topical anesthetic ... | true | note_49966 | note_49966_ reoccurrence.PATIENTS: | 824,211 |
note_49966_span_Disease Models, Animal_1800000_1850000_mid_mesh | Otologists need | OBJECTIVE: To describe a serious iatrogenic injury and propose means of reducing the risk of its reoccurrence.PATIENTS: A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topi... | true | note_49966 | note_49966_ Otologists need | 824,212 |
note_49966_span_Disease Models, Animal_1800000_1850000_mid_mesh | in clinical settings | OBJECTIVE: To describe a serious iatrogenic injury and propose means of reducing the risk of its reoccurrence.PATIENTS: A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topi... | true | note_49966 | note_49966_ in clinical settings | 824,213 |
note_49966_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | preferred. Storage of | OBJECTIVE: To describe a serious iatrogenic injury and propose means of reducing the risk of its reoccurrence.PATIENTS: A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topi... | true | note_49966 | note_49966_ preferred. Storage of | 824,214 |
note_49967_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | a societal perspective is | Whole genome sequencing (WGS) is increasingly being used in clinical practice. As a result, various healthcare professionals now encounter ethical dilemmas that were formerly confined within the genetics clinic. In addition to autonomy and well-being of both patients and their family members, which need to be balanced ... | true | note_49967 | note_49967_ a societal perspective is | 824,215 |
note_49967_span_Signal Transduction_1800000_1850000_mid_mesh | Whole genome sequencing (WGS) | <think> is increasingly being used in clinical practice. As a result, various healthcare professionals now encounter ethical dilemmas that were formerly confined within the genetics clinic. In addition to autonomy and well-being of both patients and their family members, which need to be balanced carefully, a societal ... | false | note_49967 | note_49967_Whole genome sequencing (WGS) | 824,216 |
note_49967_span_Signal Transduction_1800000_1850000_mid_mesh | pathogenic mutations. | Whole genome sequencing (WGS) is increasingly being used in clinical practice. As a result, various healthcare professionals now encounter ethical dilemmas that were formerly confined within the genetics clinic. In addition to autonomy and well-being of both patients and their family members, which need to be balanced ... | true | note_49967 | note_49967_ pathogenic mutations. | 824,217 |
note_49967_span_Signal Transduction_1800000_1850000_mid_mesh | personalized medicine | Whole genome sequencing (WGS) is increasingly being used in clinical practice. As a result, various healthcare professionals now encounter ethical dilemmas that were formerly confined within the genetics clinic. In addition to autonomy and well-being of both patients and their family members, which need to be balanced ... | true | note_49967 | note_49967_ personalized medicine | 824,218 |
note_49968_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | we study intra- | The intermolecular contribution to the spectral density of the exciton-vibrational coupling of the homotrimeric Fenna-Matthews-Olson (FMO) light-harvesting protein of green sulfur bacteria P. aestuarii is analyzed by combining a normal mode analysis of the protein with the charge density coupling method for the calcula... | false | note_49968 | note_49968_ we study intra- | 824,219 |
note_49968_span_Mice_1800000_1850000_mid_mesh | intermolecular contribution | The<think> to the spectral density of the exciton-vibrational coupling of the homotrimeric Fenna-Matthews-Olson (FMO) light-harvesting protein of green sulfur bacteria P. aestuarii is analyzed by combining a normal mode analysis of the protein with the charge density coupling method for the calculation of local transi... | false | note_49968 | note_49968_ intermolecular contribution | 824,220 |
note_49969_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | BACKGROUND: Chronic | <think> rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients with nasal poly... | false | note_49969 | note_49969_BACKGROUND: Chronic | 824,221 |
note_49969_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | subjects.CONCLUSION: | BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients wit... | true | note_49969 | note_49969_ subjects.CONCLUSION: | 824,222 |
note_49969_span_Treatment Outcome_1800000_1850000_mid_mesh | in patients with | BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled<think> nasal p... | true | note_49969 | note_49969_ in patients with | 824,223 |
note_49969_span_Treatment Outcome_1800000_1850000_mid_mesh | pollen allergy with | BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients wit... | true | note_49969 | note_49969_ pollen allergy with | 824,224 |
note_49969_span_Treatment Outcome_1800000_1850000_mid_mesh | in patients with nasal | BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients wit... | true | note_49969 | note_49969_ in patients with nasal | 824,225 |
note_49970_span_Disease Models, Animal_1800000_1850000_mid_mesh | ex vivo studies | The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human chol... | true | note_49970 | note_49970_ ex vivo studies | 824,226 |
note_49970_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | vivo studies also affirmed | The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human chol... | true | note_49970 | note_49970_ vivo studies also affirmed | 824,227 |
note_49971_span_Time Factors_1800000_1850000_mid_mesh | round-the-clock variations | An important aspect of eye health in humans and animal models of human diseases is intraocular pressure (IOP). IOP is typically measured by hand with a tonometer, so data are sparse and sporadic and<think> are not well characterized. Here we present a novel system for continuous wireless IOP and temperature measuremen... | false | note_49971 | note_49971_ round-the-clock variations | 824,228 |
note_49971_span_Time Factors_1800000_1850000_mid_mesh | a diurnal rhythm, | An important aspect of eye health in humans and animal models of human diseases is intraocular pressure (IOP). IOP is typically measured by hand with a tonometer, so data are sparse and sporadic and round-the-clock variations are not well characterized. Here we present a novel system for continuous wireless IOP and tem... | true | note_49971 | note_49971_ a diurnal rhythm, | 824,229 |
note_49971_span_Prognosis_1800000_1850000_mid_mesh | glaucoma studies | An important aspect of eye health in humans and animal models of human diseases is intraocular pressure (IOP). IOP is typically measured by hand with a tonometer, so data are sparse and sporadic and round-the-clock variations are not well characterized. Here we present a novel system for continuous wireless IOP and tem... | false | note_49971 | note_49971_ glaucoma studies | 824,230 |
note_49972_span_Signal Transduction_1800000_1850000_mid_mesh | of serum albumin | The study aimed to investigate the correlation between Parkinson's disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai'an... | false | note_49972 | note_49972_ of serum albumin | 824,231 |
note_49972_span_Signal Transduction_1800000_1850000_mid_mesh | PD patients and | The study aimed to investigate the correlation between Parkinson's disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai'an... | true | note_49972 | note_49972_ PD patients and | 824,232 |
note_49972_span_Risk Factors_1800000_1850000_mid_mesh | independent risk factors | The study aimed to investigate the correlation between Parkinson's disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai'an... | false | note_49972 | note_49972_ independent risk factors | 824,233 |
note_49973_span_Mice_1800000_1850000_mid_mesh | BACKGROUND: | <think> Given the support for the numerous benefits of breastfeeding, a better understanding of social and health determinants is necessary, particularly in under-researched populations. We examined determinants of breastfeeding initiation and duration using a national cohort of Chilean mothers.METHODS: Participants in... | false | note_49973 | note_49973_BACKGROUND: | 824,234 |
note_49973_span_Mice_1800000_1850000_mid_mesh | (M = | BACKGROUND: Given the support for the numerous benefits of breastfeeding, a better understanding of social and health determinants is necessary, particularly in under-researched populations. We examined determinants of breastfeeding initiation and duration using a national cohort of Chilean mothers.METHODS: Participant... | true | note_49973 | note_49973_ (M = | 824,235 |
note_49974_span_Male_1800000_1850000_mid_mesh | this study, | IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by an autoimmune reaction against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune complexes accumulate in th... | false | note_49974 | note_49974_ this study, | 824,236 |
note_49974_span_Male_1800000_1850000_mid_mesh | of urine from | IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by an autoimmune reaction against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune complexes accumulate in th... | true | note_49974 | note_49974_ of urine from | 824,237 |
note_49974_span_Animals_1800000_1850000_mid_mesh | an autoimmune reaction | IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by<think> against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune complexes accumulate in the glomerular me... | false | note_49974 | note_49974_ an autoimmune reaction | 824,238 |
note_49975_span_Male_1800000_1850000_mid_mesh | Methods We wanted | Background The determination of parathyroid hormone (PTH) is essential for exploring phosphocalcic disorders especially in patients with renal failure. At present, second or third generation PTH assays are available on the market from Roche Diagnostics as well as from others companies but the lack of standardization ha... | true | note_49975 | note_49975_ Methods We wanted | 824,239 |
note_49975_span_Male_1800000_1850000_mid_mesh | of populations including | Background The determination of parathyroid hormone (PTH) is essential for exploring phosphocalcic disorders especially in patients with renal failure. At present, second or third generation PTH assays are available on the market from Roche Diagnostics as well as from others companies but the lack of standardization ha... | true | note_49975 | note_49975_ of populations including | 824,240 |
note_49975_span_Male_1800000_1850000_mid_mesh | the kidney disease: | Background The determination of parathyroid hormone (PTH) is essential for exploring phosphocalcic disorders especially in patients with renal failure. At present, second or third generation PTH assays are available on the market from Roche Diagnostics as well as from others companies but the lack of standardization ha... | true | note_49975 | note_49975_ the kidney disease: | 824,241 |
note_49977_span_Male_1800000_1850000_mid_mesh | causing Urinary Tract | BACKGROUND: Escherichia coli is the most common pathogen<think> Infections (UTI). Data from the current National Surveillance program in Denmark (DANMAP) may not accurately represent the prevalence of resistant E. coli in primary care, because only urine samples from complicated cases may be forwarded to the microbiol... | false | note_49977 | note_49977_ causing Urinary Tract | 824,242 |
note_49977_span_Male_1800000_1850000_mid_mesh | with urinary tract | BACKGROUND: Escherichia coli is the most common pathogen causing Urinary Tract Infections (UTI). Data from the current National Surveillance program in Denmark (DANMAP) may not accurately represent the prevalence of resistant E. coli in primary care, because only urine samples from complicated cases may be forwarded to... | true | note_49977 | note_49977_ with urinary tract | 824,243 |
note_49977_span_Mice_1800000_1850000_mid_mesh | BACKGROUND: | <think> Escherichia coli is the most common pathogen causing Urinary Tract Infections (UTI). Data from the current National Surveillance program in Denmark (DANMAP) may not accurately represent the prevalence of resistant E. coli in primary care, because only urine samples from complicated cases may be forwarded to the... | false | note_49977 | note_49977_BACKGROUND: | 824,244 |
note_49978_span_Animals_1800000_1850000_mid_mesh | This study aimed | Toxic effects of neoadjuvant chemotherapy (NC) on nervous, hepatorenal, and pulmonary systems might affect general anesthesia depth.<think> to evaluate the effects of NC on depth of total intravenous anesthesia.This prospective observational study enrolled 60 patients undergoing elective unilateral modified radical ma... | false | note_49978 | note_49978_ This study aimed | 824,245 |
note_49978_span_Animals_1800000_1850000_mid_mesh | intravenous anesthesia.This | Toxic effects of neoadjuvant chemotherapy (NC) on nervous, hepatorenal, and pulmonary systems might affect general anesthesia depth. This study aimed to evaluate the effects of NC on depth of total<think> prospective observational study enrolled 60 patients undergoing elective unilateral modified radical mastectomy du... | true | note_49978 | note_49978_ intravenous anesthesia.This | 824,246 |
note_49978_span_Animals_1800000_1850000_mid_mesh | anesthetic effect | Toxic effects of neoadjuvant chemotherapy (NC) on nervous, hepatorenal, and pulmonary systems might affect general anesthesia depth. This study aimed to evaluate the effects of NC on depth of total intravenous anesthesia.This prospective observational study enrolled 60 patients undergoing elective unilateral modified r... | true | note_49978 | note_49978_ anesthetic effect | 824,247 |
note_49979_span_Prognosis_1800000_1850000_mid_mesh | for clinical management | OBJECTIVES: This study investigated isometric and isokinetic hip strength in individuals with and without symptomatic femoroacetabular impingement (FAI). The specific aims were to: (i) determine whether differences exist in isometric and isokinetic hip strength measures between groups; (ii) compare hip strength agonist... | false | note_49979 | note_49979_ for clinical management | 824,248 |
note_49980_span_Animals_1800000_1850000_mid_mesh | dose.OBJECTIVE: | BACKGROUND: We are interested in exploring dedicated, high-performance cardiac CT systems optimized to provide the best tradeoff between system cost, image quality, and radiation<think> We sought to identify and evaluate a broad range of CT architectures that could provide an optimal, dedicated cardiac CT solution.MET... | false | note_49980 | note_49980_ dose.OBJECTIVE: | 824,250 |
note_49980_span_Animals_1800000_1850000_mid_mesh | comparison.CONCLUSION: | BACKGROUND: We are interested in exploring dedicated, high-performance cardiac CT systems optimized to provide the best tradeoff between system cost, image quality, and radiation dose.OBJECTIVE: We sought to identify and evaluate a broad range of CT architectures that could provide an optimal, dedicated cardiac CT solu... | true | note_49980 | note_49980_ comparison.CONCLUSION: | 824,251 |
note_49980_span_Animals_1800000_1850000_mid_mesh | few alternatives were | BACKGROUND: We are interested in exploring dedicated, high-performance cardiac CT systems optimized to provide the best tradeoff between system cost, image quality, and radiation dose.OBJECTIVE: We sought to identify and evaluate a broad range of CT architectures that could provide an optimal, dedicated cardiac CT solu... | true | note_49980 | note_49980_ few alternatives were | 824,252 |
note_49980_span_Risk Factors_1800000_1850000_mid_mesh | in cardiovascular radiology, | BACKGROUND: We are interested in exploring dedicated, high-performance cardiac CT systems optimized to provide the best tradeoff between system cost, image quality, and radiation dose.OBJECTIVE: We sought to identify and evaluate a broad range of CT architectures that could provide an optimal, dedicated cardiac CT solu... | true | note_49980 | note_49980_ in cardiovascular radiology, | 824,253 |
note_49980_span_Risk Factors_1800000_1850000_mid_mesh | comparative evaluation | BACKGROUND: We are interested in exploring dedicated, high-performance cardiac CT systems optimized to provide the best tradeoff between system cost, image quality, and radiation dose.OBJECTIVE: We sought to identify and evaluate a broad range of CT architectures that could provide an optimal, dedicated cardiac CT solu... | true | note_49980 | note_49980_ comparative evaluation | 824,254 |
note_49981_span_Treatment Outcome_1800000_1850000_mid_mesh | of medicines is | The palatability<think> likely to have a significant impact on patient adherence and consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowability (e.g. size, shape, texture). However, there has been limited work undertak... | false | note_49981 | note_49981_ of medicines is | 824,255 |
note_49981_span_Treatment Outcome_1800000_1850000_mid_mesh | patient adherence and | The palatability of medicines is likely to have a significant impact on<think> consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowability (e.g. size, shape, texture). However, there has been limited work undertaken to ... | true | note_49981 | note_49981_ patient adherence and | 824,256 |
note_49981_span_Aged_1800000_1850000_mid_mesh | adherence. Tribology offers | The palatability of medicines is likely to have a significant impact on patient adherence and consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowability (e.g. size, shape, texture). However, there has been limited work ... | false | note_49981 | note_49981_ adherence. Tribology offers | 824,257 |
note_49982_span_Male_1800000_1850000_mid_mesh | porcine follicular fluid | We measured the ATP concentrations in the<think> derived from three sizes of follicles (small: 6 mm in diameter). Then, the effects of pre-treatment (100 �M each for 30 min before maturation) with antagonists for extracellular ATP receptor P2X or P2Y on the nuclear maturation rate of cumulus-cell-enclosed (COs) or -de... | false | note_49982 | note_49982_ porcine follicular fluid | 824,258 |
note_49982_span_Male_1800000_1850000_mid_mesh | oocytes may | We measured the ATP concentrations in the porcine follicular fluid derived from three sizes of follicles (small: 6 mm in diameter). Then, the effects of pre-treatment (100 �M each for 30 min before maturation) with antagonists for extracellular ATP receptor P2X or P2Y on the nuclear maturation rate of cumulus-cell-encl... | true | note_49982 | note_49982_ oocytes may | 824,259 |
note_49982_span_Adolescent_1800000_1850000_mid_mesh | before maturation) | We measured the ATP concentrations in the porcine follicular fluid derived from three sizes of follicles (small: 6 mm in diameter). Then, the effects of pre-treatment (100 �M each for 30 min<think> with antagonists for extracellular ATP receptor P2X or P2Y on the nuclear maturation rate of cumulus-cell-enclosed (COs) ... | false | note_49982 | note_49982_ before maturation) | 824,260 |
note_49982_span_Adolescent_1800000_1850000_mid_mesh | ATP receptor P2Y | We measured the ATP concentrations in the porcine follicular fluid derived from three sizes of follicles (small: 6 mm in diameter). Then, the effects of pre-treatment (100 �M each for 30 min before maturation) with antagonists for extracellular ATP receptor P2X or P2Y on the nuclear maturation rate of cumulus-cell-encl... | true | note_49982 | note_49982_ ATP receptor P2Y | 824,262 |
note_49983_span_Pregnancy_1800000_1850000_mid_mesh | HMWTg mice overexpress | Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptors (FGFRs) are key regulatory factors in osteoarthritis (OA).<think> the high molecular weight FGF2 isoforms (HMWFGF2) in osteoblast lineage and phenocopy both Hyp mice (which overexpress the HMWFGF2 isoforms in osteoblasts and osteocytes) and human... | false | note_49983 | note_49983_ HMWTg mice overexpress | 824,263 |
note_49984_span_Treatment Outcome_1800000_1850000_mid_mesh | and treated groups | Diabetes has been listed as a risk factor for various types of cancer. Cancer cell development can be promoted by increased levels of IGF-1 and hyperinsulinemia that are associated with diabetes type II. Metformin is an anti-diabetic agent and its potential antitumor impact has become the objective of numerous studies.... | false | note_49984 | note_49984_ and treated groups | 824,265 |
note_49984_span_Treatment Outcome_1800000_1850000_mid_mesh | II diabetes | Diabetes has been listed as a risk factor for various types of cancer. Cancer cell development can be promoted by increased levels of IGF-1 and hyperinsulinemia that are associated with diabetes type II. Metformin is an anti-diabetic agent and its potential antitumor impact has become the objective of numerous studies.... | true | note_49984 | note_49984_ II diabetes | 824,266 |
note_49984_span_Male_1800000_1850000_mid_mesh | in female diabetic | Diabetes has been listed as a risk factor for various types of cancer. Cancer cell development can be promoted by increased levels of IGF-1 and hyperinsulinemia that are associated with diabetes type II. Metformin is an anti-diabetic agent and its potential antitumor impact has become the objective of numerous studies.... | false | note_49984 | note_49984_ in female diabetic | 824,267 |
note_49985_span_Time Factors_1800000_1850000_mid_mesh | Transcription Activator-Like | <think> Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are known from Ralstonia ... | false | note_49985 | note_49985_Transcription Activator-Like | 824,268 |
note_49985_span_Time Factors_1800000_1850000_mid_mesh | Effectors (TALEs) | Transcription Activator-Like<think> of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are known from... | true | note_49985 | note_49985_ Effectors (TALEs) | 824,269 |
note_49985_span_Time Factors_1800000_1850000_mid_mesh | with novel residues | Transcription Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are ... | true | note_49985 | note_49985_ with novel residues | 824,270 |
note_49985_span_Adolescent_1800000_1850000_mid_mesh | Transcription | <think> Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are known ... | false | note_49985 | note_49985_Transcription | 824,271 |
note_49985_span_Adolescent_1800000_1850000_mid_mesh | common evolutionary origin | Transcription Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are ... | true | note_49985 | note_49985_ common evolutionary origin | 824,272 |
note_49985_span_Adolescent_1800000_1850000_mid_mesh | Bats. | Transcription Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation among TALE repeats. More sequence-diverse TALE-like proteins are ... | true | note_49985 | note_49985_ Bats. | 824,273 |
note_49986_span_Mice_1800000_1850000_mid_mesh | TRPC1-/- mice. | We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 channels and nitric oxide (NO) production. The present study further investigates the role of he... | false | note_49986 | note_49986_ TRPC1-/- mice. | 824,274 |
note_49986_span_Adolescent_1800000_1850000_mid_mesh | of vascular tone | We have previously provided pharmacological evidence that stimulation of calcium-sensing receptors (CaSR) induces endothelium-dependent relaxations of rabbit mesenteric arteries through activation of heteromeric TRPV4/TRPC1 channels and nitric oxide (NO) production. The present study further investigates the role of he... | false | note_49986 | note_49986_ of vascular tone | 824,275 |
note_49987_span_Surveys and Questionnaires_1800000_1850000_mid_mesh | mixed surfactant | The self-assembly of phospholipids in oil, specifically lecithin in rapeseed oil, was investigated by combining experimental and computational methods The influence of temperature, water, and free fatty acids on the onset of lecithin aggregation in the rapeseed oil was determined using the 7,7,8,8 -tetracyanoquinodimet... | true | note_49987 | note_49987_ mixed surfactant | 824,276 |
note_49987_span_Male_1800000_1850000_mid_mesh | fatty acids on | The self-assembly of phospholipids in oil, specifically lecithin in rapeseed oil, was investigated by combining experimental and computational methods The influence of temperature, water, and free<think> the onset of lecithin aggregation in the rapeseed oil was determined using the 7,7,8,8 -tetracyanoquinodimethane dy... | false | note_49987 | note_49987_ fatty acids on | 824,277 |
note_49988_span_Aged_1800000_1850000_mid_mesh | We have | <think> recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | false | note_49988 | note_49988_We have | 824,278 |
note_49988_span_Aged_1800000_1850000_mid_mesh | synthesis. Described | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained<think> herewith is the experimental procedure for the development of such a system consisting of two E. coli s... | true | note_49988 | note_49988_ synthesis. Described | 824,279 |
note_49988_span_Aged_1800000_1850000_mid_mesh | L-xylulose, as well as other | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | true | note_49988 | note_49988_ L-xylulose, as well as other | 824,280 |
note_49988_span_Signal Transduction_1800000_1850000_mid_mesh | E. coli strains that express | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | false | note_49988 | note_49988_ E. coli strains that express | 824,281 |
note_49988_span_Signal Transduction_1800000_1850000_mid_mesh | E. coli cells expressing the | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | true | note_49988 | note_49988_ E. coli cells expressing the | 824,282 |
note_49988_span_Signal Transduction_1800000_1850000_mid_mesh | 150 mM L-arabinitol, | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | true | note_49988 | note_49988_ 150 mM L-arabinitol, | 824,283 |
note_49988_span_Signal Transduction_1800000_1850000_mid_mesh | catalytic activity. | We have recently developed a simple, reusable and coupled whole-cell biocatalytic system with the capability of cofactor regeneration and biocatalyst immobilization for improved production yield and sustained synthesis. Described herewith is the experimental procedure for the development of such a system consisting of ... | true | note_49988 | note_49988_ catalytic activity. | 824,284 |
note_49989_span_Animals_1800000_1850000_mid_mesh | Kinesin-5 motor consists | <think> of two pairs of heads and tail domains, which are situated at the opposite ends of a common stalk. The two pairs of heads can bind to two antiparallel microtubules (MTs) and move on the two MTs independently towards the plus ends, sliding apart the two MTs, which is responsible for chromosome segregation during... | false | note_49989 | note_49989_Kinesin-5 motor consists | 824,285 |
note_49989_span_Animals_1800000_1850000_mid_mesh | studied analytically | Kinesin-5 motor consists of two pairs of heads and tail domains, which are situated at the opposite ends of a common stalk. The two pairs of heads can bind to two antiparallel microtubules (MTs) and move on the two MTs independently towards the plus ends, sliding apart the two MTs, which is responsible for chromosome s... | true | note_49989 | note_49989_ studied analytically | 824,286 |
note_49989_span_Adolescent_1800000_1850000_mid_mesh | for chromosome segregation | Kinesin-5 motor consists of two pairs of heads and tail domains, which are situated at the opposite ends of a common stalk. The two pairs of heads can bind to two antiparallel microtubules (MTs) and move on the two MTs independently towards the plus ends, sliding apart the two MTs, which is responsible<think> during m... | false | note_49989 | note_49989_ for chromosome segregation | 824,287 |
note_49989_span_Adolescent_1800000_1850000_mid_mesh | mitosis. | Kinesin-5 motor consists of two pairs of heads and tail domains, which are situated at the opposite ends of a common stalk. The two pairs of heads can bind to two antiparallel microtubules (MTs) and move on the two MTs independently towards the plus ends, sliding apart the two MTs, which is responsible for chromosome s... | true | note_49989 | note_49989_ mitosis. | 824,288 |
note_49990_span_Cell Line, Tumor_1800000_1850000_mid_mesh | BACKGROUND Many | <think> findings have shown that pyruvate kinase type M2 (PKM2) plays crucial roles in regulating the occurrence and development of various human cancers; however, its roles in ovarian cancer oncogenesis remain to be determined. MATERIAL AND METHODS The expression intensity of PKM2 in ovarian cancer tissues was examine... | false | note_49990 | note_49990_BACKGROUND Many | 824,289 |
note_49990_span_Cell Line, Tumor_1800000_1850000_mid_mesh | in SKOV3 and | BACKGROUND Many findings have shown that pyruvate kinase type M2 (PKM2) plays crucial roles in regulating the occurrence and development of various human cancers; however, its roles in ovarian cancer oncogenesis remain to be determined. MATERIAL AND METHODS The expression intensity of PKM2 in ovarian cancer tissues was... | true | note_49990 | note_49990_ in SKOV3 and | 824,290 |
note_49990_span_Cell Line, Tumor_1800000_1850000_mid_mesh | HEY ovarian cancer cells | BACKGROUND Many findings have shown that pyruvate kinase type M2 (PKM2) plays crucial roles in regulating the occurrence and development of various human cancers; however, its roles in ovarian cancer oncogenesis remain to be determined. MATERIAL AND METHODS The expression intensity of PKM2 in ovarian cancer tissues was... | true | note_49990 | note_49990_ HEY ovarian cancer cells | 824,291 |
note_49990_span_Disease Models, Animal_1800000_1850000_mid_mesh | various human cancers; | BACKGROUND Many findings have shown that pyruvate kinase type M2 (PKM2) plays crucial roles in regulating the occurrence and development of<think> however, its roles in ovarian cancer oncogenesis remain to be determined. MATERIAL AND METHODS The expression intensity of PKM2 in ovarian cancer tissues was examined by im... | false | note_49990 | note_49990_ various human cancers; | 824,292 |
note_49990_span_Disease Models, Animal_1800000_1850000_mid_mesh | this cancer | BACKGROUND Many findings have shown that pyruvate kinase type M2 (PKM2) plays crucial roles in regulating the occurrence and development of various human cancers; however, its roles in ovarian cancer oncogenesis remain to be determined. MATERIAL AND METHODS The expression intensity of PKM2 in ovarian cancer tissues was... | true | note_49990 | note_49990_ this cancer | 824,293 |
note_49991_span_Animals_1800000_1850000_mid_mesh | healthy adolescents, | The relationship between overweight/obesity (excess of weight [EW]) and iron deficiency (ID) is not well defined. Objective: To analyze the relationship between EW and ID in<think> assessing the contribution of new diagnostic measures of iron status and erythropoietic activity. Method: A cross-sectional study was made... | false | note_49991 | note_49991_ healthy adolescents, | 824,294 |
note_49991_span_Cell Line, Tumor_1800000_1850000_mid_mesh | in healthy adolescents, | The relationship between overweight/obesity (excess of weight [EW]) and iron deficiency (ID) is not well defined. Objective: To analyze the relationship between EW and ID<think> assessing the contribution of new diagnostic measures of iron status and erythropoietic activity. Method: A cross-sectional study was made of... | false | note_49991 | note_49991_ in healthy adolescents, | 824,295 |
note_49991_span_Cell Line, Tumor_1800000_1850000_mid_mesh | diet, BMI | The relationship between overweight/obesity (excess of weight [EW]) and iron deficiency (ID) is not well defined. Objective: To analyze the relationship between EW and ID in healthy adolescents, assessing the contribution of new diagnostic measures of iron status and erythropoietic activity. Method: A cross-sectional s... | true | note_49991 | note_49991_ diet, BMI | 824,296 |
note_49991_span_Cell Line, Tumor_1800000_1850000_mid_mesh | leukocytes, | The relationship between overweight/obesity (excess of weight [EW]) and iron deficiency (ID) is not well defined. Objective: To analyze the relationship between EW and ID in healthy adolescents, assessing the contribution of new diagnostic measures of iron status and erythropoietic activity. Method: A cross-sectional s... | true | note_49991 | note_49991_ leukocytes, | 824,297 |
note_49991_span_Cell Line, Tumor_1800000_1850000_mid_mesh | of adiposity | The relationship between overweight/obesity (excess of weight [EW]) and iron deficiency (ID) is not well defined. Objective: To analyze the relationship between EW and ID in healthy adolescents, assessing the contribution of new diagnostic measures of iron status and erythropoietic activity. Method: A cross-sectional s... | true | note_49991 | note_49991_ of adiposity | 824,298 |
note_49992_span_Risk Factors_1800000_1850000_mid_mesh | statistics. Risk of bias | PURPOSE: Laparoscopic surgery for colorectal cancer has spread globally. The usefulness of laparoscopic surgery for elderly patients was initially indicated by comparison with open surgery. However, whether the procedure is safe for elderly as well as non-elderly patients with colorectal cancer remains unclear.METHODS:... | false | note_49992 | note_49992_ statistics. Risk of bias | 824,299 |
note_49992_span_Risk Factors_1800000_1850000_mid_mesh | the Risk of Bias | PURPOSE: Laparoscopic surgery for colorectal cancer has spread globally. The usefulness of laparoscopic surgery for elderly patients was initially indicated by comparison with open surgery. However, whether the procedure is safe for elderly as well as non-elderly patients with colorectal cancer remains unclear.METHODS:... | true | note_49992 | note_49992_ the Risk of Bias | 824,300 |
note_49992_span_Pregnancy_1800000_1850000_mid_mesh | for colorectal cancer | PURPOSE: Laparoscopic surgery<think> has spread globally. The usefulness of laparoscopic surgery for elderly patients was initially indicated by comparison with open surgery. However, whether the procedure is safe for elderly as well as non-elderly patients with colorectal cancer remains unclear.METHODS: In this revie... | false | note_49992 | note_49992_ for colorectal cancer | 824,301 |
note_49992_span_Pregnancy_1800000_1850000_mid_mesh | for elderly patients | PURPOSE: Laparoscopic surgery for colorectal cancer has spread globally. The usefulness of laparoscopic surgery<think> was initially indicated by comparison with open surgery. However, whether the procedure is safe for elderly as well as non-elderly patients with colorectal cancer remains unclear.METHODS: In this revi... | true | note_49992 | note_49992_ for elderly patients | 824,302 |
note_49993_span_Adolescent_1800000_1850000_mid_mesh | four adenocarcinomas | Prostate cancer is a common cause of death worldwide. Here, we isolated cancer stem cells (CSCs) from<think> of the prostate (Gleason scores from 3 + 3 up to 4 + 5). CSCs were characterized by the expression of the stem cell markers TWIST, the epithelial cell adhesion molecule (EPCAM), the transcription factors SNAI1 ... | false | note_49993 | note_49993_ four adenocarcinomas | 824,303 |
note_49994_span_Disease Models, Animal_1800000_1850000_mid_mesh | population. The gene dosage | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled f... | false | note_49994 | note_49994_ population. The gene dosage | 824,304 |
note_49994_span_Disease Models, Animal_1800000_1850000_mid_mesh | could predict the severity | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled f... | true | note_49994 | note_49994_ could predict the severity | 824,305 |
note_49994_span_Adolescent_1800000_1850000_mid_mesh | the coronary artery | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with<think> disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled for this stud... | false | note_49994 | note_49994_ the coronary artery | 824,306 |
note_49994_span_Adolescent_1800000_1850000_mid_mesh | in Chinese Han | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD<think> population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled for this... | true | note_49994 | note_49994_ in Chinese Han | 824,307 |
note_49994_span_Adolescent_1800000_1850000_mid_mesh | descending artery disease | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled f... | true | note_49994 | note_49994_ descending artery disease | 824,308 |
note_49994_span_Adolescent_1800000_1850000_mid_mesh | predict the severity of | Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled f... | true | note_49994 | note_49994_ predict the severity of | 824,309 |
note_49995_span_Animals_1800000_1850000_mid_mesh | Researchers have | <think> examined a number of typologies of juvenile sex offenders, including victim age. Using data from psychological evaluations and the Multiphasic Sex Inventory-II (MSI-II; [Psychological assessment of sex offenders, 2010]), this study compared child offenders (i.e., victims were more than 4�years younger), peer of... | false | note_49995 | note_49995_Researchers have | 824,310 |
note_49995_span_Animals_1800000_1850000_mid_mesh | 4�years | Researchers have examined a number of typologies of juvenile sex offenders, including victim age. Using data from psychological evaluations and the Multiphasic Sex Inventory-II (MSI-II; [Psychological assessment of sex offenders, 2010]), this study compared child offenders (i.e., victims were more than<think> younger)... | true | note_49995 | note_49995_ 4�years | 824,311 |
note_49995_span_Aged_1800000_1850000_mid_mesh | the Multiphasic | Researchers have examined a number of typologies of juvenile sex offenders, including victim age. Using data from psychological evaluations and<think> Sex Inventory-II (MSI-II; [Psychological assessment of sex offenders, 2010]), this study compared child offenders (i.e., victims were more than 4�years younger), peer o... | false | note_49995 | note_49995_ the Multiphasic | 824,312 |
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